## Fri Jan  3 08:29:53 2025
## emapper-2.1.12
## /data/home/zhuyingjie/miniforge3/envs/eggnog/bin/emapper.py -i /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/mmseqs_cluster/PRJNA847709/SRR19627611/SRR19627611_p_cluster_rep_seq.fasta --output PRJNA847709_SRR19627611 --data_dir /data/software/eggnog_database -m diamond --sensmode fast --output_dir /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/annotation --temp_dir /data/software/eggnog_database/temp --excel --dbmem --cpu 24
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
k59_1355867_1	565045.NOR51B_2776	1.09e-99	305.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,1RPTG@1236|Gammaproteobacteria,1J8GB@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Pyrimidine nucleoside phosphorylase C-terminal domain	-	-	2.4.2.4	ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
k59_1649724_1	740709.A10D4_04290	1.81e-44	152.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,2QEYU@267893|Idiomarinaceae	1236|Gammaproteobacteria	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2564,iB21_1397.B21_02422,iBWG_1329.BWG_2328,iEC55989_1330.EC55989_2852,iECBD_1354.ECBD_1117,iECB_1328.ECB_02458,iECDH10B_1368.ECDH10B_2732,iECDH1ME8569_1439.ECDH1ME8569_2491,iECD_1391.ECD_02458,iECH74115_1262.ECH74115_3800,iECIAI1_1343.ECIAI1_2675,iECO103_1326.ECO103_3142,iECO111_1330.ECO111_3290,iECO26_1355.ECO26_3611,iECSE_1348.ECSE_2852,iECSP_1301.ECSP_3509,iECW_1372.ECW_m2792,iECs_1301.ECs3430,iEKO11_1354.EKO11_1169,iEcDH1_1363.EcDH1_1104,iEcE24377_1341.EcE24377A_2850,iEcHS_1320.EcHS_A2719,iEcolC_1368.EcolC_1113,iG2583_1286.G2583_3145,iJO1366.b2564,iJR904.b2564,iWFL_1372.ECW_m2792,iY75_1357.Y75_RS13390	PdxJ
k59_1649724_2	1158292.JPOE01000005_gene89	7.47e-16	74.3	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,2VT0P@28216|Betaproteobacteria,1KKSJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
k59_416506_1	2340.JV46_22540	1.35e-105	332.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1J57N@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1708074_1	270374.MELB17_15469	1.59e-78	253.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,4645B@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_1708074_2	870187.Thini_0588	1.29e-21	93.2	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,45ZUP@72273|Thiotrichales	72273|Thiotrichales	E	Aminotransferase	aspC2	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_651610_1	311402.Avi_4212	5.21e-11	63.2	2DSWY@1|root,33HRR@2|Bacteria,1NKGU@1224|Proteobacteria,2UMY1@28211|Alphaproteobacteria,4BF5V@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1828405_1	765911.Thivi_3416	4.41e-20	87.0	COG0607@1|root,COG0607@2|Bacteria,1N9FQ@1224|Proteobacteria,1SJC3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1828405_2	768671.ThimaDRAFT_0808	8.59e-247	686.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,1WXN7@135613|Chromatiales	135613|Chromatiales	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_1239064_1	457415.HMPREF1006_02606	2.44e-75	238.0	COG0075@1|root,COG0075@2|Bacteria,3TA05@508458|Synergistetes	508458|Synergistetes	E	PFAM Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_1355872_1	1121933.AUHH01000031_gene3067	1.95e-78	249.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4DN2S@85009|Propionibacteriales	201174|Actinobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0008150,GO:0040007	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
k59_242299_1	1049564.TevJSym_ba00030	3.3e-83	273.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1J4NP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA polymerase III, alpha subunit	dnaE	GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_948079_1	1380354.JIAN01000009_gene3896	1.64e-36	132.0	COG2025@1|root,COG2025@2|Bacteria,2GJWH@201174|Actinobacteria,4F155@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM Electron transfer flavoprotein alpha subunit	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
k59_360834_1	1267005.KB911260_gene3554	1.39e-85	276.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,3N6J9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_651617_1	396588.Tgr7_1275	6.66e-79	245.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1WWD8@135613|Chromatiales	135613|Chromatiales	O	Belongs to the HypD family	-	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
k59_123179_1	768671.ThimaDRAFT_0937	6.7e-122	367.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales	135613|Chromatiales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_8436_1	526225.Gobs_1996	6.65e-93	308.0	COG2114@1|root,COG3629@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4EUWB@85013|Frankiales	201174|Actinobacteria	K	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Guanylate_cyc,NB-ARC,Trans_reg_C
k59_1300297_1	765912.Thimo_0057	1.66e-108	318.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1WWSM@135613|Chromatiales	135613|Chromatiales	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_67386_1	1122185.N792_12010	2.14e-62	218.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1X4MI@135614|Xanthomonadales	135614|Xanthomonadales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_651618_1	1123253.AUBD01000010_gene2160	1.43e-09	62.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,1X5DD@135614|Xanthomonadales	135614|Xanthomonadales	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri
k59_651618_2	935567.JAES01000021_gene2646	2.24e-35	126.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1X4FR@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
k59_416526_1	367299.JOEE01000001_gene2110	9.44e-76	238.0	COG3214@1|root,COG3214@2|Bacteria,2GP6G@201174|Actinobacteria,4FEJN@85021|Intrasporangiaceae	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
k59_1649745_1	455436.DS989810_gene601	1.06e-102	306.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,1RMHP@1236|Gammaproteobacteria,465M8@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006928,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0010212,GO:0031668,GO:0033554,GO:0034641,GO:0040011,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_1300304_1	935839.JAGJ01000006_gene3434	1.19e-169	530.0	COG0366@1|root,COG1523@1|root,COG0366@2|Bacteria,COG1523@2|Bacteria,2GKK1@201174|Actinobacteria,4F3GE@85017|Promicromonosporaceae	201174|Actinobacteria	M	Alpha-amylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Alpha-amylase_C,CBM_48,DUF3372
k59_1300304_2	446469.Sked_28050	1.15e-06	48.9	COG0788@1|root,COG0788@2|Bacteria,2GM0G@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT,ACT_6,Formyl_trans_N
k59_710229_1	329726.AM1_1835	2.37e-10	62.4	COG2321@1|root,COG2321@2|Bacteria,1G20J@1117|Cyanobacteria	1117|Cyanobacteria	S	neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
k59_710229_2	1026882.MAMP_01644	5.54e-101	306.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,4606R@72273|Thiotrichales	72273|Thiotrichales	L	ATPase (AAA	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_242330_1	1267005.KB911263_gene1352	3.62e-57	196.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,3N80Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	ABC transporter transmembrane region	msbA	-	-	ko:K02021,ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_768080_1	596151.DesfrDRAFT_1883	1.31e-30	124.0	COG0784@1|root,COG1148@1|root,COG2072@1|root,COG0784@2|Bacteria,COG1148@2|Bacteria,COG2072@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2M7SC@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FAD_oxidored,Fer4,Fer4_7,NAD_binding_8,Pyr_redox_2,Response_reg
k59_1474032_1	794846.AJQU01000025_gene189	9.46e-39	145.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,4B9S2@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S1C family	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
k59_592882_2	1454004.AW11_00250	6.07e-19	83.2	2EJDA@1|root,33D4B@2|Bacteria,1NJG2@1224|Proteobacteria,2VXQP@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_592882_3	1123392.AQWL01000002_gene1812	7.13e-108	332.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2VH3P@28216|Betaproteobacteria,1KS58@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_1179810_1	1439940.BAY1663_00630	6.54e-80	258.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_1239098_1	1121106.JQKB01000004_gene2433	1.44e-45	156.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,2JP9V@204441|Rhodospirillales	204441|Rhodospirillales	EP	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1239098_2	911045.PSE_4833	2.95e-35	128.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2TT4V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_710237_2	768671.ThimaDRAFT_2344	1.3e-47	168.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1WW1J@135613|Chromatiales	135613|Chromatiales	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	-	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_67414_1	909613.UO65_0514	1.4e-34	125.0	28HUD@1|root,32XP7@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2398)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2398
k59_67414_2	875328.JDM601_1264	1.31e-42	156.0	2CC51@1|root,2ZCBX@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2397
k59_67415_1	1123013.AUIC01000003_gene280	1.03e-05	46.2	COG0719@1|root,COG0719@2|Bacteria,2GKCZ@201174|Actinobacteria,4FM34@85023|Microbacteriaceae	201174|Actinobacteria	O	Uncharacterized protein family (UPF0051)	sufB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_67415_2	590998.Celf_1694	6.32e-49	171.0	COG0719@1|root,COG0719@2|Bacteria,2GJNV@201174|Actinobacteria,4F0FF@85016|Cellulomonadaceae	201174|Actinobacteria	O	TIGRFAM FeS assembly protein SufD	sufD	GO:0008150,GO:0009605,GO:0009607,GO:0040007,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_592889_1	768671.ThimaDRAFT_3763	2.42e-85	261.0	COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,1T1KM@1236|Gammaproteobacteria,1WXUD@135613|Chromatiales	135613|Chromatiales	G	6-phosphogluconate dehydrogenase	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
k59_123207_1	367299.JOEE01000004_gene1234	2.27e-113	345.0	COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria,4FF2D@85021|Intrasporangiaceae	201174|Actinobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
k59_889218_1	1226994.AMZB01000134_gene4637	8.34e-270	746.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1YE90@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	ubiD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	iECO111_1330.ECO111_4669	UbiD
k59_1474050_1	883126.HMPREF9710_02056	5.2e-115	338.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2VHC8@28216|Betaproteobacteria,472DK@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
k59_768093_1	492774.JQMB01000002_gene940	4.46e-53	189.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,4B7WC@82115|Rhizobiaceae	28211|Alphaproteobacteria	EQ	N-methylhydantoinase A acetone carboxylase, beta subunit	oplA	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_1239111_1	381764.Fnod_0387	6.12e-06	49.3	COG4656@1|root,COG4656@2|Bacteria,2GCCQ@200918|Thermotogae	200918|Thermotogae	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,RnfC_N,SLBB
k59_8497_1	314264.ROS217_07325	2.66e-06	48.5	COG1176@1|root,COG1176@2|Bacteria,1MU1Y@1224|Proteobacteria,2TTJ6@28211|Alphaproteobacteria,46NV4@74030|Roseovarius	28211|Alphaproteobacteria	P	COG1176 ABC-type spermidine putrescine transport system, permease component I	-	-	-	ko:K02054,ko:K11071	ko02010,ko02024,map02010,map02024	M00193,M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.11.1	-	-	BPD_transp_1
k59_8497_2	89187.ISM_03810	5.27e-62	198.0	COG1177@1|root,COG1177@2|Bacteria,1MUQD@1224|Proteobacteria,2U1YB@28211|Alphaproteobacteria,46NZR@74030|Roseovarius	28211|Alphaproteobacteria	P	COG1177 ABC-type spermidine putrescine transport system, permease component II	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
k59_1828465_1	1235279.C772_02320	1.63e-38	144.0	COG1169@1|root,COG1169@2|Bacteria,1TSRT@1239|Firmicutes,4H9K8@91061|Bacilli,26DHF@186818|Planococcaceae	91061|Bacilli	HQ	Isochorismate synthase	menF	-	5.4.4.2	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
k59_1414927_2	985665.HPL003_07530	2.07e-52	183.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,4HAHY@91061|Bacilli,26SZ3@186822|Paenibacillaceae	91061|Bacilli	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_8498_1	1335757.SPICUR_09405	3.89e-71	235.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWI3@135613|Chromatiales	135613|Chromatiales	L	PFAM UvrD REP helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_360884_1	1144305.PMI02_04518	6.23e-147	430.0	COG3515@1|root,COG3515@2|Bacteria,1NRMK@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_827450_1	765912.Thimo_2980	1.69e-53	181.0	COG1524@1|root,COG1524@2|Bacteria,1R2II@1224|Proteobacteria,1RQDZ@1236|Gammaproteobacteria,1X2CP@135613|Chromatiales	135613|Chromatiales	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
k59_299490_1	314345.SPV1_09378	1.29e-18	79.3	COG3369@1|root,COG3369@2|Bacteria,1N6QZ@1224|Proteobacteria	1224|Proteobacteria	S	Zinc finger cdgsh-type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
k59_299490_2	765911.Thivi_3470	1.77e-118	351.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1WWT4@135613|Chromatiales	135613|Chromatiales	U	Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_1063043_1	1307759.JOMJ01000003_gene927	1.04e-120	369.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,42SZ0@68525|delta/epsilon subdivisions,2WPIR@28221|Deltaproteobacteria,2MAQX@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	DEAD-like helicase	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
k59_1003023_1	768671.ThimaDRAFT_2780	5.82e-11	70.5	COG0457@1|root,COG0457@2|Bacteria,1PYTB@1224|Proteobacteria,1RSFQ@1236|Gammaproteobacteria,1WWNG@135613|Chromatiales	135613|Chromatiales	S	Tetratricopeptide repeat	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	TPR_16
k59_1531875_1	548479.HMPREF0573_11323	2.13e-19	86.7	COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,4D4S1@85005|Actinomycetales	201174|Actinobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	GO:0008150,GO:0040007	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
k59_1415563_1	1304865.JAGF01000001_gene3752	3.16e-137	410.0	COG1418@1|root,COG1418@2|Bacteria,2I9DW@201174|Actinobacteria	201174|Actinobacteria	M	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
k59_1415563_2	1123065.ATWL01000002_gene1718	4.32e-63	200.0	COG2137@1|root,COG2137@2|Bacteria,2GMRF@201174|Actinobacteria	201174|Actinobacteria	S	regulatory protein RecX	recX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
k59_1415563_3	743718.Isova_1246	9.32e-102	315.0	COG0468@1|root,COG1372@1|root,COG0468@2|Bacteria,COG1372@2|Bacteria,2GJ4P@201174|Actinobacteria,4F38E@85017|Promicromonosporaceae	201174|Actinobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_1708623_1	1120953.AUBH01000010_gene87	1.12e-44	166.0	COG1629@1|root,COG4771@2|Bacteria,1N6JG@1224|Proteobacteria,1RP10@1236|Gammaproteobacteria,465FE@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
k59_1180544_1	7955.ENSDARP00000112065	4.15e-05	52.8	KOG1125@1|root,KOG1125@2759|Eukaryota,38C1T@33154|Opisthokonta,3BFN9@33208|Metazoa,3D0KU@33213|Bilateria,480FS@7711|Chordata,491J1@7742|Vertebrata,4A02Y@7898|Actinopterygii	33208|Metazoa	S	Peroxisomal biogenesis factor 5	PEX5	GO:0000038,GO:0000268,GO:0001764,GO:0002119,GO:0002164,GO:0003008,GO:0003674,GO:0005048,GO:0005052,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005778,GO:0005782,GO:0005794,GO:0005829,GO:0006082,GO:0006464,GO:0006605,GO:0006612,GO:0006625,GO:0006629,GO:0006631,GO:0006635,GO:0006807,GO:0006810,GO:0006886,GO:0006928,GO:0006996,GO:0007005,GO:0007006,GO:0007029,GO:0007031,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0008022,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009791,GO:0009987,GO:0010256,GO:0012505,GO:0015031,GO:0015833,GO:0015919,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016477,GO:0016558,GO:0016560,GO:0016561,GO:0016567,GO:0017038,GO:0019395,GO:0019538,GO:0019752,GO:0019899,GO:0021537,GO:0021543,GO:0021795,GO:0021885,GO:0021895,GO:0021953,GO:0021987,GO:0022008,GO:0022029,GO:0022607,GO:0030154,GO:0030182,GO:0030258,GO:0030900,GO:0031090,GO:0031267,GO:0031333,GO:0031903,GO:0031907,GO:0031974,GO:0032446,GO:0032459,GO:0032460,GO:0032462,GO:0032463,GO:0032501,GO:0032502,GO:0032787,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034440,GO:0034613,GO:0036211,GO:0040008,GO:0040011,GO:0040014,GO:0040018,GO:0042221,GO:0042277,GO:0042493,GO:0042579,GO:0042886,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043254,GO:0043412,GO:0043436,GO:0043574,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0044743,GO:0045046,GO:0045184,GO:0045927,GO:0046395,GO:0046907,GO:0047485,GO:0048468,GO:0048513,GO:0048518,GO:0048519,GO:0048523,GO:0048638,GO:0048639,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0048870,GO:0050789,GO:0050793,GO:0050794,GO:0050877,GO:0050896,GO:0050905,GO:0051020,GO:0051094,GO:0051128,GO:0051129,GO:0051179,GO:0051234,GO:0051239,GO:0051240,GO:0051259,GO:0051262,GO:0051641,GO:0051649,GO:0051674,GO:0055085,GO:0055114,GO:0060322,GO:0061024,GO:0065002,GO:0065003,GO:0065007,GO:0070013,GO:0070647,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071806,GO:0071840,GO:0072329,GO:0072347,GO:0072594,GO:0072657,GO:0072662,GO:0072663,GO:0090150,GO:0098588,GO:0098805,GO:1901090,GO:1901091,GO:1901093,GO:1901094,GO:1901564,GO:1901575	-	ko:K13342,ko:K20915	ko04146,ko04621,map04146,map04621	-	-	-	ko00000,ko00001,ko04131	3.A.20.1	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
k59_652237_1	472759.Nhal_2360	5.2e-96	290.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1WX0P@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_1356513_1	367299.JOEE01000014_gene911	9.59e-88	284.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GJD0@201174|Actinobacteria,4FEDE@85021|Intrasporangiaceae	201174|Actinobacteria	L	COG0210 Superfamily I DNA and RNA	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,PDDEXK_1,UvrD-helicase,UvrD_C
k59_1708627_1	396588.Tgr7_2544	1.13e-14	71.6	28YDQ@1|root,2ZK87@2|Bacteria,1P5BI@1224|Proteobacteria,1STGK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1708627_2	326297.Sama_1964	1.79e-23	96.7	COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,1RMUT@1236|Gammaproteobacteria,2Q8XI@267890|Shewanellaceae	1236|Gammaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	GO:0003674,GO:0003824,GO:0004766,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0010487,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0043918,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	iECED1_1282.ECED1_0125,iPC815.YPO3411,iSDY_1059.SDY_0028	Spermine_synt_N,Spermine_synth
k59_1063699_1	1207076.ALAT01000115_gene3636	1.09e-70	224.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1Z28G@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006520,GO:0006553,GO:0006563,GO:0006564,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0034641,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046394,GO:0046451,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901615,GO:1901617	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iEcE24377_1341.EcE24377A_1004,iPC815.YPO1389,iYL1228.KPN_00935	Aminotran_5
k59_243525_2	1122609.AUGT01000015_gene1994	2.77e-85	253.0	COG2030@1|root,COG2030@2|Bacteria,2GN4R@201174|Actinobacteria,4DNJW@85009|Propionibacteriales	201174|Actinobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
k59_1590894_1	40571.JOEA01000021_gene6826	1.19e-44	164.0	COG2304@1|root,COG2304@2|Bacteria,2GJRP@201174|Actinobacteria	201174|Actinobacteria	S	tyrosinase	-	-	1.14.18.1	ko:K00505	ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916	M00042	R00731,R02078,R02363,R02383,R04693,R04884	RC00046,RC00150,RC00180	ko00000,ko00001,ko00002,ko01000	-	-	-	Tyrosinase
k59_1301176_1	637905.SVI_0325	1.73e-35	129.0	2C5U9@1|root,2Z9NJ@2|Bacteria,1R8VZ@1224|Proteobacteria,1RWKX@1236|Gammaproteobacteria,2Q8VA@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
k59_534845_1	1232437.KL662050_gene5290	2.94e-67	224.0	COG2204@1|root,COG5000@1|root,COG2204@2|Bacteria,COG5000@2|Bacteria,1RBB9@1224|Proteobacteria,42R73@68525|delta/epsilon subdivisions,2WMPX@28221|Deltaproteobacteria,2MMXA@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Response_reg
k59_948967_1	690850.Desaf_1237	1.94e-35	138.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,42NNX@68525|delta/epsilon subdivisions,2WJ9P@28221|Deltaproteobacteria,2MD1V@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	AAA domain	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22
k59_890067_2	382464.ABSI01000012_gene2201	6.43e-78	256.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C
k59_890068_1	123214.PERMA_0318	1.02e-08	56.2	COG1959@1|root,COG1959@2|Bacteria,2G59A@200783|Aquificae	200783|Aquificae	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
k59_890068_2	626939.HMPREF9443_00394	1.22e-32	124.0	COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,4H2BT@909932|Negativicutes	909932|Negativicutes	C	nitric oxide	roo	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
k59_1240014_1	711393.AYRX01000087_gene5066	6.88e-05	51.2	COG2188@1|root,COG2188@2|Bacteria,2IAW7@201174|Actinobacteria	201174|Actinobacteria	K	gntR family	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
k59_361775_1	396588.Tgr7_1428	6.01e-26	100.0	2EC4Z@1|root,3363S@2|Bacteria,1N9YG@1224|Proteobacteria,1SSSK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_361775_2	391615.ABSJ01000037_gene878	9.42e-11	63.5	28W6N@1|root,2ZI7A@2|Bacteria,1PA2A@1224|Proteobacteria,1SVQS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_123884_1	926564.KI911615_gene4448	1.05e-212	593.0	COG0379@1|root,COG0379@2|Bacteria,2GM59@201174|Actinobacteria,4F3QU@85017|Promicromonosporaceae	201174|Actinobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
k59_476062_1	1207076.ALAT01000030_gene37	2.78e-29	107.0	COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,1SCG6@1236|Gammaproteobacteria,1Z36Q@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
k59_476062_2	1123518.ARWI01000001_gene1474	9.51e-25	107.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,45ZXV@72273|Thiotrichales	72273|Thiotrichales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_1301193_1	446469.Sked_33410	6.44e-62	201.0	COG1902@1|root,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria	201174|Actinobacteria	C	NADH flavin oxidoreductase NADH oxidase	namA	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_1474956_1	471853.Bcav_3282	9.83e-110	325.0	COG1194@1|root,COG1194@2|Bacteria,2GJD9@201174|Actinobacteria	201174|Actinobacteria	L	adenine glycosylase	mutY	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_890079_1	999541.bgla_1g32150	1.66e-95	304.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria,1K19S@119060|Burkholderiaceae	28216|Betaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_1240015_1	1232437.KL662020_gene705	1.23e-224	632.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_593479_1	1232437.KL662050_gene5369	6.56e-08	55.8	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M97@68525|delta/epsilon subdivisions,2WJB4@28221|Deltaproteobacteria,2MJB7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	hmcB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4,Fer4_7
k59_593479_2	1304885.AUEY01000001_gene3189	1.69e-35	130.0	COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42P2Q@68525|delta/epsilon subdivisions,2WKC2@28221|Deltaproteobacteria,2MJCP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Polysulphide reductase, NrfD	hmcC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	NrfD
k59_1417778_2	270374.MELB17_14982	3.69e-14	69.7	2ENKU@1|root,33G87@2|Bacteria,1NMH6@1224|Proteobacteria,1SGDI@1236|Gammaproteobacteria,468YW@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1710446_1	47839.CCAU010000013_gene4822	8.75e-20	94.7	COG2937@1|root,COG2937@2|Bacteria,2GMQF@201174|Actinobacteria,232HX@1762|Mycobacteriaceae	201174|Actinobacteria	I	Belongs to the GPAT DAPAT family	plsB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_419114_1	471853.Bcav_1144	1.35e-38	141.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria	201174|Actinobacteria	D	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_419114_2	562973.HMPREF0059_01999	5.75e-36	143.0	COG1403@1|root,COG3170@1|root,COG1403@2|Bacteria,COG3170@2|Bacteria,2GP2N@201174|Actinobacteria,4D58M@85005|Actinomycetales	201174|Actinobacteria	V	the current gene model (or a revised gene model) may contain a frame shift	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_247369_1	768671.ThimaDRAFT_2567	3.53e-22	89.0	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1WYHD@135613|Chromatiales	135613|Chromatiales	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
k59_830186_1	1499967.BAYZ01000026_gene1558	3.05e-215	612.0	COG0376@1|root,COG0376@2|Bacteria,2NQNQ@2323|unclassified Bacteria	2|Bacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_770227_1	1001240.GY21_14335	3.04e-40	147.0	COG1649@1|root,COG1649@2|Bacteria,2GKNP@201174|Actinobacteria,4FQF8@85023|Microbacteriaceae	201174|Actinobacteria	S	Glycosyl hydrolase-like 10	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,GHL10
k59_70992_1	335543.Sfum_1615	5.53e-19	85.5	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,42MTW@68525|delta/epsilon subdivisions,2WJ0J@28221|Deltaproteobacteria,2MRC6@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	AAA domain (Cdc48 subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
k59_70992_2	335543.Sfum_1614	1.48e-47	165.0	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,42N7R@68525|delta/epsilon subdivisions,2WJBI@28221|Deltaproteobacteria,2MR3A@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	VWA containing CoxE family protein	-	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
k59_951703_1	545264.KB898745_gene1361	1.26e-82	255.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1WWPK@135613|Chromatiales	135613|Chromatiales	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1592770_1	1410626.JHXB01000003_gene1150	7.55e-14	72.8	COG1648@1|root,COG1648@2|Bacteria,1VA2E@1239|Firmicutes,24N6M@186801|Clostridia,27P80@186928|unclassified Lachnospiraceae	186801|Clostridia	H	Putative NAD(P)-binding	cysG	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M
k59_364482_2	314271.RB2654_01890	3.44e-09	56.6	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR15@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_125982_1	1120934.KB894472_gene4296	9.52e-52	173.0	COG1018@1|root,COG1018@2|Bacteria,2GJCV@201174|Actinobacteria,4DYVR@85010|Pseudonocardiales	201174|Actinobacteria	C	Flavodoxin reductases (Ferredoxin-NADPH reductases) family 1	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,NAD_binding_1,p450
k59_364485_2	765912.Thimo_2445	7.02e-13	68.9	COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,1S9FW@1236|Gammaproteobacteria,1WXHE@135613|Chromatiales	135613|Chromatiales	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
k59_1768894_1	1380356.JNIK01000015_gene2479	1.13e-20	89.4	2DBEB@1|root,32TXC@2|Bacteria,2IRDQ@201174|Actinobacteria,4ET9W@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1242836_1	243231.GSU3031	2.14e-82	260.0	COG3829@1|root,COG3829@2|Bacteria,1MXSB@1224|Proteobacteria,42PHW@68525|delta/epsilon subdivisions,2WJSS@28221|Deltaproteobacteria,43TCI@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat
k59_13702_2	68260.JOAY01000065_gene523	1.07e-56	182.0	COG0512@1|root,COG0512@2|Bacteria,2GJUX@201174|Actinobacteria	201174|Actinobacteria	EH	Glutamine amidotransferase of anthranilate synthase	trpG	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_1303930_1	324602.Caur_3875	6.72e-88	274.0	COG1640@1|root,COG1640@2|Bacteria,2G668@200795|Chloroflexi,376Q1@32061|Chloroflexia	32061|Chloroflexia	G	PFAM glycoside hydrolase, family 77	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_364491_1	631362.Thi970DRAFT_04866	8.8e-114	352.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1WXK8@135613|Chromatiales	135613|Chromatiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1067320_2	367299.JOEE01000004_gene1157	7.32e-122	353.0	COG0681@1|root,COG0681@2|Bacteria,2IMJG@201174|Actinobacteria,4FGBZ@85021|Intrasporangiaceae	201174|Actinobacteria	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
k59_1652578_1	886293.Sinac_4941	1.45e-76	250.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	ybbN	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_477962_1	765911.Thivi_1777	1.1e-13	67.4	COG1436@1|root,COG1436@2|Bacteria,1MZUE@1224|Proteobacteria,1SATX@1236|Gammaproteobacteria,1WYZV@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_F
k59_477962_2	631362.Thi970DRAFT_02656	6.42e-49	163.0	COG1390@1|root,COG1390@2|Bacteria,1R8BT@1224|Proteobacteria,1S1WN@1236|Gammaproteobacteria,1WXX4@135613|Chromatiales	135613|Chromatiales	C	V-type proton ATPase subunit E	-	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
k59_247413_1	717785.HYPMC_3322	4.53e-41	143.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	2.7.7.49	ko:K00986,ko:K07497	-	-	-	-	ko00000,ko01000	-	-	-	HTH_32,rve
k59_247413_2	717785.HYPMC_3323	1.22e-48	157.0	COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2963 Transposase and inactivated derivatives	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_595281_1	1255043.TVNIR_1957	1.14e-56	179.0	COG0838@1|root,COG0838@2|Bacteria	2|Bacteria	C	NADH dehydrogenase (ubiquinone) activity	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_595281_2	765914.ThisiDRAFT_1073	6.15e-07	49.3	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,1WW6I@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_247414_1	1517416.IDAT_03570	1.95e-127	394.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,2QEY1@267893|Idiomarinaceae	1236|Gammaproteobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_71025_1	511.JT27_14330	1.91e-06	49.3	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH41@28216|Betaproteobacteria,3T1YP@506|Alcaligenaceae	28216|Betaproteobacteria	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	phbC2	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	PHBC_N,PhaC_N
k59_71025_2	314278.NB231_02578	6.26e-45	165.0	COG2199@1|root,COG5001@1|root,COG2199@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9
k59_1358456_1	1049564.TevJSym_as00690	1.15e-100	305.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RMVW@1236|Gammaproteobacteria,1J4W8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_595284_1	471853.Bcav_2477	3.1e-76	242.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the peptidase M16 family	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_892757_1	443143.GM18_2922	1.07e-152	434.0	COG4804@1|root,COG4804@2|Bacteria,1NBWK@1224|Proteobacteria,42NXR@68525|delta/epsilon subdivisions,2WJ11@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1016)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1016
k59_301891_1	1122612.AUBA01000009_gene2071	2.65e-18	88.6	COG4585@1|root,COG4585@2|Bacteria,1RKV1@1224|Proteobacteria,2U32D@28211|Alphaproteobacteria,2KDGC@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_1534418_1	272562.CA_C1849	1.41e-28	118.0	COG2081@1|root,COG2081@2|Bacteria,1TQ6E@1239|Firmicutes,247S5@186801|Clostridia,36E7B@31979|Clostridiaceae	186801|Clostridia	S	HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
k59_830226_1	1132855.KB913035_gene677	1.75e-52	177.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,2VJZJ@28216|Betaproteobacteria,2KNQE@206350|Nitrosomonadales	206350|Nitrosomonadales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
k59_1242860_1	713586.KB900536_gene392	1.27e-32	123.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1WWFM@135613|Chromatiales	135613|Chromatiales	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_365341_1	864069.MicloDRAFT_00049420	7.84e-80	258.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,1JSYN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16
k59_893557_1	1121403.AUCV01000001_gene1010	8.33e-41	150.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42PZ6@68525|delta/epsilon subdivisions,2WKNQ@28221|Deltaproteobacteria,2MI1H@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Amino acid kinase family	-	-	1.1.1.3,2.7.2.4	ko:K00928,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3
k59_1653184_1	768671.ThimaDRAFT_2003	2.83e-21	85.9	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,1S8TC@1236|Gammaproteobacteria,1X2H5@135613|Chromatiales	135613|Chromatiales	O	Sulfurtransferase TusA	-	-	-	-	-	-	-	-	-	-	-	-	TusA
k59_1653184_2	1286106.MPL1_03538	1.8e-21	88.6	COG2210@1|root,COG2210@2|Bacteria,1RDUG@1224|Proteobacteria,1RRM7@1236|Gammaproteobacteria,4612C@72273|Thiotrichales	72273|Thiotrichales	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
k59_1304785_1	1280954.HPO_11154	4.13e-118	348.0	COG1804@1|root,COG1804@2|Bacteria,1MU5U@1224|Proteobacteria,2TRIZ@28211|Alphaproteobacteria,43ZI2@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_952565_1	413404.Rmag_0035	5.28e-106	320.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1J4DV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	iJN746.PP_0104	COX1
k59_1593334_1	558884.JRGM01000176_gene1447	9.84e-85	256.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,1RMF7@1236|Gammaproteobacteria,1Y4KH@135624|Aeromonadales	135624|Aeromonadales	O	Belongs to the GST superfamily	-	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_C_2,GST_N
k59_478547_1	640081.Dsui_1159	5.18e-89	271.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,2VHKM@28216|Betaproteobacteria,2KVMG@206389|Rhodocyclales	206389|Rhodocyclales	O	Belongs to the HypD family	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
k59_185379_1	595536.ADVE02000001_gene828	2.34e-05	51.6	COG4097@1|root,COG4097@2|Bacteria,1MV9P@1224|Proteobacteria,2TUCM@28211|Alphaproteobacteria,36ZQQ@31993|Methylocystaceae	28211|Alphaproteobacteria	P	FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_8,Ferric_reduct,NAD_binding_1
k59_713665_1	479431.Namu_5349	6.72e-129	374.0	COG0169@1|root,COG0169@2|Bacteria,2GPXV@201174|Actinobacteria,4EUPY@85013|Frankiales	201174|Actinobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	-	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_dh_N
k59_713665_2	1238450.VIBNISOn1_970103	2.14e-46	168.0	COG1609@1|root,COG1609@2|Bacteria,1N2TE@1224|Proteobacteria,1RS21@1236|Gammaproteobacteria,1Y04Q@135623|Vibrionales	135623|Vibrionales	K	Bacterial regulatory proteins, lacI family	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
k59_713665_3	1206733.BAGC01000041_gene1873	4.32e-18	87.4	COG3559@1|root,COG3559@2|Bacteria	2|Bacteria	M	Exporter of polyketide antibiotics	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_248526_1	105559.Nwat_0275	1.35e-48	167.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1WXB7@135613|Chromatiales	135613|Chromatiales	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_1769468_1	572477.Alvin_2212	3.12e-38	140.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1WWPJ@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
k59_419707_1	234267.Acid_1440	6.21e-29	115.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	6.5.1.3	ko:K14680	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos_2,RNA_lig_T4_1
k59_365361_1	987059.RBXJA2T_03021	5.2e-112	337.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VI77@28216|Betaproteobacteria,1KJ65@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Carboxyl transferase domain	accB	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1711024_1	1040987.AZUY01000004_gene3252	3.15e-82	272.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,43ITA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	V	Efflux pump membrane transporter	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_365363_1	517418.Ctha_1565	2.58e-26	106.0	COG4608@1|root,COG4608@2|Bacteria,1FDGY@1090|Chlorobi	1090|Chlorobi	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_1068147_1	1157708.KB907450_gene6121	6.98e-18	89.0	COG2114@1|root,COG2114@2|Bacteria,1RBTC@1224|Proteobacteria,2VS62@28216|Betaproteobacteria,4AE5Z@80864|Comamonadaceae	28216|Betaproteobacteria	T	SMART adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,dCache_1
k59_1653205_2	765913.ThidrDRAFT_1371	2.84e-38	135.0	COG2231@1|root,COG2231@2|Bacteria,1RDJ8@1224|Proteobacteria,1RUHP@1236|Gammaproteobacteria,1WXXG@135613|Chromatiales	135613|Chromatiales	L	PFAM HhH-GPD	-	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
k59_1304807_1	396588.Tgr7_3010	1.26e-110	333.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1WWX1@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_1534951_1	998674.ATTE01000001_gene4480	4.76e-43	147.0	COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,1RMEM@1236|Gammaproteobacteria,460NM@72273|Thiotrichales	72273|Thiotrichales	E	ABC transporter	-	-	-	ko:K11963	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran
k59_1123083_1	1380347.JNII01000008_gene4187	4.16e-72	227.0	COG0395@1|root,COG0395@2|Bacteria,2GJNN@201174|Actinobacteria,4EUW8@85013|Frankiales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K10234	ko02010,map02010	M00201,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
k59_14852_1	1210046.B277_05104	2.75e-98	294.0	COG0673@1|root,COG0673@2|Bacteria,2GJCY@201174|Actinobacteria,4FGK0@85021|Intrasporangiaceae	201174|Actinobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_365378_1	998674.ATTE01000001_gene2757	3.18e-51	177.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,45ZYF@72273|Thiotrichales	72273|Thiotrichales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_365378_2	631362.Thi970DRAFT_00913	7.46e-46	159.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1WXJR@135613|Chromatiales	135613|Chromatiales	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_1534957_1	1123355.JHYO01000008_gene2681	2.25e-109	337.0	COG2172@1|root,COG2203@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,1PFBR@1224|Proteobacteria,2U1RE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Sigma factor PP2C-like phosphatases	rsbU	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c_2,SpoIIE
k59_248559_1	396588.Tgr7_0483	1.02e-88	283.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1WVXZ@135613|Chromatiales	135613|Chromatiales	MU	type I secretion outer membrane protein, TolC	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
k59_248559_2	42565.FP66_02780	4.44e-27	111.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1XHB6@135619|Oceanospirillales	135619|Oceanospirillales	M	transferase	waaA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N
k59_1478706_1	1049564.TevJSym_ac01410	8.66e-69	214.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,1J63Q@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression	dksA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
k59_1478706_2	1163617.SCD_n02324	2.13e-59	193.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
k59_1068168_1	1379270.AUXF01000003_gene3543	1.76e-164	470.0	COG1013@1|root,COG1013@2|Bacteria,1ZSWT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_1068168_2	240015.ACP_0328	3.83e-48	172.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,3Y3NX@57723|Acidobacteria,2JKIA@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
k59_419736_1	933262.AXAM01000079_gene2205	3.58e-93	277.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,42MZP@68525|delta/epsilon subdivisions,2WJ1Z@28221|Deltaproteobacteria,2MHWH@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_1593365_1	1123393.KB891328_gene695	2.58e-106	311.0	COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,2VQTE@28216|Betaproteobacteria,1KTCZ@119069|Hydrogenophilales	119069|Hydrogenophilales	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_71928_1	270374.MELB17_20131	2.6e-71	220.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,1S1Z1@1236|Gammaproteobacteria,466EY@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_71928_2	1121921.KB898709_gene394	3.43e-15	70.9	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,1S5V2@1236|Gammaproteobacteria,2PNJW@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	J	Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
k59_1304846_1	382464.ABSI01000012_gene2201	1.31e-30	125.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C
k59_418905_2	935839.JAGJ01000009_gene561	2.29e-79	244.0	COG1595@1|root,COG1595@2|Bacteria,2IKQ7@201174|Actinobacteria,4F5ZB@85017|Promicromonosporaceae	201174|Actinobacteria	K	Sigma-70, region 4	litS	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
k59_184450_1	555778.Hneap_1706	1.65e-41	138.0	COG0011@1|root,COG0011@2|Bacteria,1N1NM@1224|Proteobacteria,1SAV8@1236|Gammaproteobacteria,1WZPV@135613|Chromatiales	135613|Chromatiales	S	Thiamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
k59_654053_1	717785.HYPMC_1593	2.03e-63	210.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2TRWB@28211|Alphaproteobacteria,3N6F1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_1477498_1	243277.VC_0543	5.1e-21	92.4	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,1RMHP@1236|Gammaproteobacteria,1XSES@135623|Vibrionales	135623|Vibrionales	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_1477498_2	765912.Thimo_2429	3.08e-23	95.5	COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,1WYJU@135613|Chromatiales	135613|Chromatiales	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
k59_1652311_1	941449.dsx2_1325	7.15e-45	162.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,42M2B@68525|delta/epsilon subdivisions,2WJDZ@28221|Deltaproteobacteria,2M8IC@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	arginine decarboxylase	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
k59_1067014_1	1415780.JPOG01000001_gene2865	7.38e-79	243.0	COG0596@1|root,COG0596@2|Bacteria,1MUSF@1224|Proteobacteria,1RP4C@1236|Gammaproteobacteria,1X3HD@135614|Xanthomonadales	135614|Xanthomonadales	S	Alpha beta hydrolase	dhaA	-	-	ko:K22318	-	-	-	-	ko00000	-	-	-	Abhydrolase_1
k59_1067014_2	402881.Plav_0799	7.78e-22	94.7	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,1JN19@119043|Rhodobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	alkK	-	6.2.1.44,6.2.1.48	ko:K00666,ko:K02182,ko:K20034	ko00920,map00920	-	R10820	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_892406_1	1123261.AXDW01000005_gene2641	3.4e-71	232.0	COG4805@1|root,COG4805@2|Bacteria,1PIM6@1224|Proteobacteria,1RRW7@1236|Gammaproteobacteria,1X3BX@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_654064_1	1193181.BN10_690013	2.14e-64	214.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4FEWA@85021|Intrasporangiaceae	201174|Actinobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_536580_1	1031711.RSPO_c01195	7.16e-13	68.6	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,1K29A@119060|Burkholderiaceae	28216|Betaproteobacteria	L	helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_536580_2	596153.Alide_1290	4.6e-08	56.6	COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,2VNM5@28216|Betaproteobacteria,4ACQQ@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1182497_1	1174528.JH992893_gene5975	4.15e-130	404.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,1G15G@1117|Cyanobacteria,1JHXK@1189|Stigonemataceae	1117|Cyanobacteria	G	Transaldolase/Fructose-6-phosphate aldolase	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
k59_1067028_1	1095772.CAHH01000002_gene1868	4.29e-101	301.0	COG0175@1|root,COG0175@2|Bacteria,2GN85@201174|Actinobacteria	201174|Actinobacteria	EH	sulfate adenylyltransferase	cysD	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
k59_1652323_1	644282.Deba_1899	1.74e-81	259.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_13287_1	224911.27350502	1.68e-75	241.0	COG3239@1|root,COG3239@2|Bacteria,1MY4I@1224|Proteobacteria,2TUF8@28211|Alphaproteobacteria,3JS8B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	fatty acid desaturase	des	-	1.14.19.23,1.14.19.45	ko:K10255	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
k59_1710273_1	1123065.ATWL01000003_gene608	1.65e-34	134.0	COG1028@1|root,COG1028@2|Bacteria,2GJCZ@201174|Actinobacteria	201174|Actinobacteria	IQ	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1710273_2	471853.Bcav_3585	1.17e-188	538.0	COG0183@1|root,COG0183@2|Bacteria,2GJI8@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	fadI	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_364205_1	356851.JOAN01000014_gene1991	2.85e-86	268.0	COG3299@1|root,COG3299@2|Bacteria,2GMXM@201174|Actinobacteria	201174|Actinobacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
k59_1592586_1	909663.KI867150_gene809	1.1e-10	60.8	COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WRFB@28221|Deltaproteobacteria,2MQN7@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	PFAM Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1477527_1	448385.sce4763	1.45e-102	326.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,42PMM@68525|delta/epsilon subdivisions,2X37C@28221|Deltaproteobacteria,2YUQZ@29|Myxococcales	28221|Deltaproteobacteria	S	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
k59_1710278_1	93220.LV28_23070	8.06e-114	331.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2VIIR@28216|Betaproteobacteria,1K0Y1@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
k59_1831769_2	745411.B3C1_03195	0.000919	43.1	COG3788@1|root,COG3788@2|Bacteria,1RDHP@1224|Proteobacteria,1S3PN@1236|Gammaproteobacteria,1J759@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	relative of glutathione S-transferase, MAPEG superfamily	yecN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07136	-	-	-	-	ko00000	-	-	-	MAPEG
k59_951452_1	1713.JOFV01000007_gene2928	8.31e-103	323.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4F1W0@85016|Cellulomonadaceae	201174|Actinobacteria	L	PFAM DEAD DEAH box helicase domain protein	deaD	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K05592,ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
k59_951452_2	592029.DDD_2542	2.61e-30	113.0	COG2343@1|root,COG2343@2|Bacteria,4NSX4@976|Bacteroidetes	976|Bacteroidetes	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
k59_125769_1	935261.JAGL01000023_gene103	2.67e-107	332.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,43IB9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the GcvT family	Sardh	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006575,GO:0006576,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008480,GO:0009056,GO:0009063,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019695,GO:0019752,GO:0019842,GO:0031406,GO:0031974,GO:0033218,GO:0034641,GO:0035999,GO:0036094,GO:0042133,GO:0042135,GO:0042219,GO:0042402,GO:0042426,GO:0042558,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046483,GO:0046653,GO:0046997,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072341,GO:0097159,GO:0097164,GO:1901052,GO:1901053,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.5.3.19	ko:K19191	ko00760,ko01120,map00760,map01120	-	R10102	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
k59_247005_1	631362.Thi970DRAFT_01066	2.82e-31	119.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1X044@135613|Chromatiales	135613|Chromatiales	L	PFAM Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_247005_2	631362.Thi970DRAFT_02055	3.59e-41	146.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1X044@135613|Chromatiales	135613|Chromatiales	L	PFAM Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_364212_1	768671.ThimaDRAFT_1087	4.59e-290	811.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1WWHQ@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_418944_1	933262.AXAM01000006_gene1845	5.31e-82	253.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,42NF2@68525|delta/epsilon subdivisions,2WJ7Q@28221|Deltaproteobacteria,2MI9U@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_1831778_1	1268635.Loa_02488	1.07e-15	80.5	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria,1JE42@118969|Legionellales	118969|Legionellales	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_1831778_2	305700.B447_11767	8.72e-22	87.0	COG0298@1|root,COG0298@2|Bacteria,1N76Y@1224|Proteobacteria,2VVZH@28216|Betaproteobacteria,2KX70@206389|Rhodocyclales	206389|Rhodocyclales	O	Hydrogenase assembly chaperone hypC hupF	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
k59_1477544_2	1123368.AUIS01000003_gene1810	5.06e-77	241.0	COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,1RYFC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	CBS-domain-containing membrane protein	-	-	-	ko:K07168	-	-	-	-	ko00000	-	-	-	HPP
k59_712796_1	467661.RKLH11_3754	1.22e-57	189.0	COG1802@1|root,COG1802@2|Bacteria,1MXNF@1224|Proteobacteria,2U1PK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Regulatory protein GntR HTH	MA20_15070	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_712796_2	1440053.JOEI01000001_gene1478	6.3e-05	45.1	COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	oxc	-	4.1.1.8	ko:K01577	ko00630,ko01100,map00630,map01100	-	R01908	RC00620	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0118c	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1303665_1	631362.Thi970DRAFT_04125	2.51e-91	296.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWSZ@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1242554_1	446469.Sked_36870	2.05e-31	119.0	COG0834@1|root,COG0834@2|Bacteria,2GJH8@201174|Actinobacteria	201174|Actinobacteria	ET	Belongs to the bacterial solute-binding protein 3 family	gluB	-	-	ko:K10005	ko02010,map02010	M00233	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.9	-	-	SBP_bac_3
k59_1242554_2	935839.JAGJ01000007_gene3163	3.42e-140	401.0	COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria,4F3U5@85017|Promicromonosporaceae	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	gluA	-	-	ko:K10008	ko02010,map02010	M00233	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.9	-	-	ABC_tran
k59_477800_1	472759.Nhal_0357	3.23e-75	236.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1WXUS@135613|Chromatiales	1236|Gammaproteobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_1710287_1	572477.Alvin_1844	4.07e-126	380.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,1T1W9@1236|Gammaproteobacteria,1WW1S@135613|Chromatiales	135613|Chromatiales	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1710287_2	1411685.U062_00546	9.74e-06	44.3	COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,1SCJS@1236|Gammaproteobacteria,1J6XM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
k59_1067064_1	590998.Celf_0701	1.2e-101	327.0	COG3459@1|root,COG3459@2|Bacteria	2|Bacteria	G	carbohydrate binding	cbpA	-	2.4.1.333	ko:K21298	-	-	-	-	ko00000,ko01000	-	GH94	-	Glyco_hydro_36,Glyco_transf_36
k59_1067064_2	1304865.JAGF01000001_gene2497	2.43e-69	220.0	COG1609@1|root,COG1609@2|Bacteria,2GJV7@201174|Actinobacteria,4F0RV@85016|Cellulomonadaceae	201174|Actinobacteria	K	PFAM periplasmic binding protein LacI transcriptional regulator	celR	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
k59_125783_1	604354.TSIB_1204	3.13e-83	260.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
k59_1592605_1	1216976.AX27061_2158	9.93e-27	107.0	COG0204@1|root,COG0204@2|Bacteria,1RDN7@1224|Proteobacteria,2VNX6@28216|Betaproteobacteria,3T3MH@506|Alcaligenaceae	28216|Betaproteobacteria	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
k59_13340_2	543632.JOJL01000027_gene2914	9.05e-31	110.0	COG3462@1|root,COG3462@2|Bacteria	2|Bacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
k59_952713_2	2340.JV46_02650	9.03e-47	150.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,1S8ZV@1236|Gammaproteobacteria,1J6N0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S binding domain	fdx1	-	-	-	-	-	-	-	-	-	-	-	Fer4
k59_713779_1	472759.Nhal_3891	4.1e-86	265.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1WXGR@135613|Chromatiales	135613|Chromatiales	NU	TIGRFAM type IV pilus assembly protein PilM	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_365493_1	438753.AZC_1773	8.59e-20	92.0	COG1884@1|root,COG1884@2|Bacteria,1NR2K@1224|Proteobacteria,2TSYT@28211|Alphaproteobacteria,3EY6K@335928|Xanthobacteraceae	28211|Alphaproteobacteria	I	Methylmalonyl-CoA mutase	mutA	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k59_126791_1	367299.JOEE01000005_gene3516	6.7e-50	176.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,2GN09@201174|Actinobacteria,4FFMF@85021|Intrasporangiaceae	201174|Actinobacteria	E	glutamate synthase	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_126791_2	367299.JOEE01000005_gene3517	1.43e-39	142.0	COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria,4FECB@85021|Intrasporangiaceae	201174|Actinobacteria	E	provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate	gltD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3858c	Fer4_20,Pyr_redox_2
k59_1769566_1	497964.CfE428DRAFT_0990	1.52e-54	189.0	COG0514@1|root,COG0514@2|Bacteria,46S7V@74201|Verrucomicrobia	74201|Verrucomicrobia	L	TIGRFAM ATP-dependent DNA helicase, RecQ family	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
k59_185499_1	768671.ThimaDRAFT_2737	1.73e-104	325.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales	135613|Chromatiales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_595923_1	1122194.AUHU01000008_gene3285	1.65e-45	155.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,464H0@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
k59_15034_1	42256.RradSPS_2487	2.62e-68	223.0	COG1914@1|root,COG1914@2|Bacteria,2GJSM@201174|Actinobacteria	201174|Actinobacteria	P	H( )-stimulated, divalent metal cation uptake system	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
k59_830910_1	1096930.L284_09155	1.13e-29	110.0	COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria,2K3Y6@204457|Sphingomonadales	204457|Sphingomonadales	L	COG2963 Transposase and inactivated derivatives	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1359088_2	216594.MMAR_2734	2.66e-41	147.0	COG0446@1|root,COG0446@2|Bacteria,2IB5R@201174|Actinobacteria,23756@1762|Mycobacteriaceae	201174|Actinobacteria	S	but shows high identity with sulfide-quinone reductase from chlorobium tepidum	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_15050_2	1225184.ALXE01000023_gene1844	2.72e-25	102.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria,3VXXS@53335|Pantoea	1236|Gammaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_478660_1	745411.B3C1_09448	5.75e-31	114.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria,1J676@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
k59_478660_2	631362.Thi970DRAFT_03780	3.36e-38	141.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales	135613|Chromatiales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_302535_2	1267005.KB911256_gene2037	5.37e-115	336.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2TQNC@28211|Alphaproteobacteria,3N69E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
k59_1535044_1	335543.Sfum_2394	5.01e-74	232.0	COG0535@1|root,COG0535@2|Bacteria,1R8PU@1224|Proteobacteria,42Q6I@68525|delta/epsilon subdivisions,2WKZV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_302536_1	443255.SCLAV_4823	8.97e-28	115.0	COG0477@1|root,COG0477@2|Bacteria,2IBIG@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1711135_1	1122182.KB903833_gene5464	1.07e-30	124.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,4D9V2@85008|Micromonosporales	201174|Actinobacteria	H	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_713812_1	1163617.SCD_n02368	7.4e-97	299.0	COG0028@1|root,COG0028@2|Bacteria,1MWVW@1224|Proteobacteria,2VQU4@28216|Betaproteobacteria	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1833109_1	710111.FraQA3DRAFT_5841	5.01e-116	340.0	COG0451@1|root,COG0451@2|Bacteria,2I2EG@201174|Actinobacteria,4EUA3@85013|Frankiales	201174|Actinobacteria	GM	epimerase dehydratase	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_713814_1	52598.EE36_15107	1.84e-32	125.0	COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,2TSXQ@28211|Alphaproteobacteria,3ZW01@60136|Sulfitobacter	28211|Alphaproteobacteria	F	Inosine-uridine preferring nucleoside hydrolase	rihA	-	3.2.2.1	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
k59_1769591_1	1044.EH31_06290	1.68e-12	67.8	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,2K0PX@204457|Sphingomonadales	204457|Sphingomonadales	P	Ammonium Transporter	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_713816_1	55529.EKX39525	2.14e-22	95.5	COG2226@1|root,KOG1540@2759|Eukaryota	2759|Eukaryota	H	2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity	COQ5	-	2.1.1.201	ko:K06127	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00128	R04983,R08774	RC00003,RC01253	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_713816_2	1333998.M2A_0343	6.68e-16	76.3	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2TS4C@28211|Alphaproteobacteria,4BQ29@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_1769592_2	545276.KB898724_gene1885	0.000485	42.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,1WW8H@135613|Chromatiales	135613|Chromatiales	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_595950_1	1049564.TevJSym_bo00090	1.09e-86	270.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,1RR3N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG2010 Cytochrome c, mono- and diheme variants	nirN	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_1359107_1	314278.NB231_04002	2.83e-72	233.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1WWAE@135613|Chromatiales	135613|Chromatiales	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_830939_1	765911.Thivi_0897	6.09e-85	270.0	COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,1RNZU@1236|Gammaproteobacteria,1WXEZ@135613|Chromatiales	135613|Chromatiales	K	PFAM Ribonuclease II	-	-	3.1.13.1	ko:K01147	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNB
k59_248786_1	1049564.TevJSym_ac01020	1.09e-19	87.8	COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,1RPDG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_248786_2	765912.Thimo_3317	2.84e-97	300.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,1WWBR@135613|Chromatiales	135613|Chromatiales	G	PFAM glycoside hydrolase, family 77	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_1123180_1	593907.Celgi_1895	4.63e-87	269.0	COG0330@1|root,COG0330@2|Bacteria,2GJ1U@201174|Actinobacteria,4F0ZD@85016|Cellulomonadaceae	201174|Actinobacteria	O	prohibitin homologues	hflK	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7
k59_1418558_1	261292.Nit79A3_1774	1.9e-79	245.0	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,2VH00@28216|Betaproteobacteria,37274@32003|Nitrosomonadales	28216|Betaproteobacteria	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_478693_1	379731.PST_0562	3.69e-64	210.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1YZYR@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	E	COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases	gltD	GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iEC042_1314.EC042_3503,iYL1228.KPN_03625	Fer4_11,Fer4_20,Pyr_redox_2
k59_830946_1	926569.ANT_09430	2.67e-84	259.0	COG0709@1|root,COG0709@2|Bacteria,2G5W4@200795|Chloroflexi	200795|Chloroflexi	H	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
k59_1418562_1	237368.SCABRO_02678	1.53e-86	269.0	COG0308@1|root,COG0308@2|Bacteria	2|Bacteria	E	peptide catabolic process	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_0348	Cofac_haem_bdg,PDZ_2,Peptidase_M1,Peptidase_M28
k59_1535070_1	1123269.NX02_01350	3.58e-87	280.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,2TSHC@28211|Alphaproteobacteria,2K0UX@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_1068337_1	555778.Hneap_0344	1.8e-57	180.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,1WYHF@135613|Chromatiales	135613|Chromatiales	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_1068337_2	1122212.AULO01000014_gene1221	0.000792	40.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,1S3Q2@1236|Gammaproteobacteria,1XJQU@135619|Oceanospirillales	135619|Oceanospirillales	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
k59_248807_1	768671.ThimaDRAFT_3401	2.11e-52	177.0	2CB8R@1|root,2Z90U@2|Bacteria,1R4DV@1224|Proteobacteria,1RPSZ@1236|Gammaproteobacteria,1WZX3@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1653361_1	1211777.BN77_p2140015	1.96e-17	84.7	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VEYD@28211|Alphaproteobacteria,4BNCT@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_595964_2	1120949.KB903339_gene7874	1.74e-20	94.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
k59_478695_1	177437.HRM2_21410	6.31e-49	164.0	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,42U9S@68525|delta/epsilon subdivisions,2WQ1X@28221|Deltaproteobacteria,2MK54@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF882)	ycbK	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
k59_1243888_1	349521.HCH_05370	1.79e-61	201.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1XHRY@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1243888_2	626887.J057_18035	2.82e-69	220.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,46540@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	GO:0003674,GO:0003824,GO:0004076,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	iZ_1308.Z0994	BATS,Radical_SAM
k59_1304999_1	1442599.JAAN01000006_gene834	9.76e-67	228.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,1RN48@1236|Gammaproteobacteria,1X36U@135614|Xanthomonadales	135614|Xanthomonadales	CE	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
k59_1359123_2	879212.DespoDRAFT_00640	2.42e-37	130.0	2E0F6@1|root,32W1G@2|Bacteria,1N6I3@1224|Proteobacteria,42V01@68525|delta/epsilon subdivisions,2WQWS@28221|Deltaproteobacteria,2MMAB@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_893797_1	331869.BAL199_05389	4.59e-25	109.0	COG3015@1|root,COG3126@1|root,COG3187@1|root,COG3015@2|Bacteria,COG3126@2|Bacteria,COG3187@2|Bacteria,1Q2DV@1224|Proteobacteria,2VB2I@28211|Alphaproteobacteria,4BT60@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Type III secretion system lipoprotein chaperone (YscW)	-	-	-	-	-	-	-	-	-	-	-	-	META,YscW
k59_248816_1	1316936.K678_11136	8.65e-79	246.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,2TR6D@28211|Alphaproteobacteria,2JQNH@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_595966_1	1479237.JMLY01000001_gene1275	6.74e-75	249.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,464YC@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG5009 Membrane carboxypeptidase penicillin-binding protein	mrcA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_655192_1	1187851.A33M_1391	3.37e-80	270.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,2U2F7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1653366_1	1245471.PCA10_56040	1.17e-172	505.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1YEPQ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	L	UvrD-like helicase C-terminal domain	uvrD	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0042802,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_952816_2	314278.NB231_14153	1.34e-28	111.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,1RPU9@1236|Gammaproteobacteria,1WW6Z@135613|Chromatiales	135613|Chromatiales	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
k59_1535077_1	1049564.TevJSym_af00420	4.04e-129	392.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1J56P@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_1243898_1	316067.Geob_0406	5.99e-119	363.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,42MV3@68525|delta/epsilon subdivisions,2WJZB@28221|Deltaproteobacteria,43SX6@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	DEAD DEAH box helicase domain protein	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
k59_713853_1	87626.PTD2_17475	1.71e-33	134.0	COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,2Q0ZH@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfC	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0055114	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB
k59_419871_1	1049564.TevJSym_ag00400	7.61e-100	299.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1J4GF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_0421	Glycos_trans_3N,Glycos_transf_3
k59_1711176_1	1523503.JPMY01000041_gene425	1.2e-31	119.0	COG0596@1|root,COG0596@2|Bacteria,1QIT9@1224|Proteobacteria,1RNP9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1711176_2	351348.Maqu_1097	4.33e-30	115.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,465BH@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	COG1131 ABC-type multidrug transport system, ATPase component	yadG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_15159_1	446466.Cfla_0484	1.38e-78	243.0	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4F0VA@85016|Cellulomonadaceae	201174|Actinobacteria	K	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form	cobB	-	-	-	-	-	-	-	-	-	-	-	SIR2
k59_1183585_1	298654.FraEuI1c_0823	6.94e-110	343.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria	201174|Actinobacteria	EQ	PFAM Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_537553_1	246197.MXAN_4128	2.16e-48	170.0	COG2433@1|root,COG2433@2|Bacteria,1RE5Q@1224|Proteobacteria,42WSA@68525|delta/epsilon subdivisions,2WRPQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_713859_1	225937.HP15_1249	6.14e-23	102.0	COG0591@1|root,COG0642@1|root,COG0784@1|root,COG0591@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,464E5@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG0591 Na proline symporter	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg,SSF
k59_126876_1	467200.ACFA01000917_gene1436	5.79e-06	47.0	COG5361@1|root,COG5361@2|Bacteria,2GRDZ@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_126876_2	58123.JOFJ01000024_gene3429	9.89e-20	90.1	COG1309@1|root,COG1309@2|Bacteria,2H131@201174|Actinobacteria,4EQC9@85012|Streptosporangiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1593497_1	292415.Tbd_0489	1.24e-64	203.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2VKZV@28216|Betaproteobacteria,1KRBM@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Inhibitor of apoptosis-promoting Bax1	-	-	-	ko:K19416	-	M00742	-	-	ko00000,ko00002,ko02000	1.A.14.2.1	-	-	Bax1-I
k59_72137_1	1267005.KB911258_gene97	8.81e-44	151.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2TRK9@28211|Alphaproteobacteria,3N688@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
k59_72137_2	1267005.KB911258_gene98	2.16e-20	85.1	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,2U7G4@28211|Alphaproteobacteria,3N6VI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
k59_365613_1	1049564.TevJSym_bc00360	2.11e-149	428.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,1RNTJ@1236|Gammaproteobacteria,1JB7M@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
k59_365613_2	572477.Alvin_2038	1.37e-10	60.1	COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,1RRNM@1236|Gammaproteobacteria,1WW5S@135613|Chromatiales	135613|Chromatiales	C	nitrate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_830979_1	1049564.TevJSym_ab00630	7.35e-57	189.0	COG0577@1|root,COG0577@2|Bacteria,1QRYR@1224|Proteobacteria,1S0ZU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	tagS	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_1123212_1	221103.XP_007846593.1	4.58e-18	88.6	KOG1867@1|root,KOG1867@2759|Eukaryota	2759|Eukaryota	O	ubiquitin carboxyl-terminal hydrolase	UBP1	GO:0003674,GO:0003824,GO:0004843,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0009987,GO:0012505,GO:0016579,GO:0016787,GO:0019538,GO:0019783,GO:0036211,GO:0036459,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0070646,GO:0070647,GO:0071704,GO:0101005,GO:0140096,GO:1901564	3.4.19.12	ko:K11851,ko:K11870	ko04137,map04137	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04121,ko04131	-	-	-	UCH
k59_893826_1	697282.Mettu_1623	3.46e-25	103.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1XEFM@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1244965_2	1448389.BAVQ01000016_gene4082	1.67e-44	159.0	COG1271@1|root,COG1271@2|Bacteria,2GJE4@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome bd ubiquinol oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_1123831_1	1267005.KB911259_gene3885	5.3e-60	189.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2TSKM@28211|Alphaproteobacteria,3N6TD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
k59_1123831_2	1267005.KB911259_gene3886	1.39e-36	127.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,2U70Z@28211|Alphaproteobacteria,3N6RG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
k59_73164_1	648757.Rvan_0600	1.33e-108	324.0	COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,2U4HS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	sulfite reductase	-	-	1.8.99.5	ko:K11180	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_1359808_1	479433.Caci_0509	5.67e-25	118.0	COG1226@1|root,COG1226@2|Bacteria,2I8YK@201174|Actinobacteria	201174|Actinobacteria	P	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)	-	-	-	-	-	-	-	-	-	-	-	-	RyR,TrkA_N
k59_1244973_1	987059.RBXJA2T_11628	4.43e-66	212.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2VIM2@28216|Betaproteobacteria,1KJGU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_1654197_1	323261.Noc_1207	1.6e-88	270.0	28JVF@1|root,2Z9KD@2|Bacteria,1MXZ6@1224|Proteobacteria,1RY7E@1236|Gammaproteobacteria,1WX1M@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_420621_1	314278.NB231_16708	5.1e-60	205.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,1WWAN@135613|Chromatiales	135613|Chromatiales	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1306090_1	1288494.EBAPG3_3210	2.07e-29	115.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2VH15@28216|Betaproteobacteria,371YX@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_1480011_1	367299.JOEE01000001_gene2013	9.3e-110	324.0	COG0451@1|root,COG0451@2|Bacteria,2GNT1@201174|Actinobacteria,4FF9R@85021|Intrasporangiaceae	201174|Actinobacteria	GM	epimerase	galE2	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0501	Epimerase
k59_250285_1	1380354.JIAN01000010_gene3068	6.4e-71	222.0	COG0566@1|root,COG0566@2|Bacteria,2GJ12@201174|Actinobacteria,4F1PP@85016|Cellulomonadaceae	201174|Actinobacteria	J	PFAM tRNA rRNA methyltransferase (SpoU)	spoU2	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
k59_127663_1	562983.HMPREF0433_01640	3.18e-17	81.6	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,4HA1D@91061|Bacilli,3WDWZ@539002|Bacillales incertae sedis	91061|Bacilli	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_1359816_1	497964.CfE428DRAFT_2954	3.35e-36	129.0	COG0511@1|root,COG0511@2|Bacteria,46SXA@74201|Verrucomicrobia	74201|Verrucomicrobia	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
k59_831774_1	1504981.KO116_2586	1.79e-10	63.2	COG2105@1|root,COG2105@2|Bacteria,1RHE8@1224|Proteobacteria,1S708@1236|Gammaproteobacteria,1XKFK@135619|Oceanospirillales	135619|Oceanospirillales	S	AIG2-like family	-	-	-	-	-	-	-	-	-	-	-	-	AIG2_2
k59_831774_2	243233.MCA0603	2.67e-28	110.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1XEPY@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
k59_1306109_1	644282.Deba_2842	5.54e-75	244.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42M9D@68525|delta/epsilon subdivisions,2WJ43@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1834298_1	1049564.TevJSym_an00780	2.67e-137	406.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,1T2DW@1236|Gammaproteobacteria,1J4QJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EQ	Hydantoinase B/oxoprolinase	hyuB	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_714628_1	330214.NIDE3598	1.34e-134	390.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
k59_1419400_1	1280689.AUJC01000004_gene491	3.32e-16	74.7	COG0607@1|root,COG0607@2|Bacteria,1U0PW@1239|Firmicutes,24RKU@186801|Clostridia,36KH8@31979|Clostridiaceae	186801|Clostridia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,TusA
k59_1419400_2	644801.Psest_0165	1.34e-25	100.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1Z1BF@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	GO:0002790,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0034613,GO:0042886,GO:0043952,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051082,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0072321	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
k59_1359819_2	243231.GSU0546	1.69e-26	103.0	COG1186@1|root,COG1186@2|Bacteria,1NBAD@1224|Proteobacteria,42UTT@68525|delta/epsilon subdivisions,2WQZK@28221|Deltaproteobacteria,43VGU@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	PFAM Class I peptide chain release factor	-	-	-	-	-	-	-	-	-	-	-	-	RF-1
k59_831783_1	1123320.KB889697_gene8905	3.35e-101	301.0	COG2159@1|root,COG2159@2|Bacteria,2GN9D@201174|Actinobacteria	201174|Actinobacteria	S	Amidohydrolase	pcmD	-	4.2.1.83	ko:K10220	ko00362,ko01120,map00362,map01120	-	R04478	RC00498	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
k59_1419408_1	767434.Fraau_1137	7.12e-75	241.0	COG1760@1|root,COG1760@2|Bacteria,1MUZN@1224|Proteobacteria,1RMJZ@1236|Gammaproteobacteria,1X3P1@135614|Xanthomonadales	135614|Xanthomonadales	E	Serine dehydratase	sdaA	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha,SDH_beta
k59_1535777_1	1151061.CAJY01000036_gene1499	8.8e-104	311.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase	aspB	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_303359_1	469383.Cwoe_2908	2.41e-35	138.0	COG0531@1|root,COG0589@1|root,COG0531@2|Bacteria,COG0589@2|Bacteria,2GJ75@201174|Actinobacteria,4CPFI@84995|Rubrobacteria	84995|Rubrobacteria	ET	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,Usp
k59_16723_1	1245475.ANAE01000110_gene3252	1.72e-97	304.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,2GM65@201174|Actinobacteria,4EI7D@85012|Streptosporangiales	201174|Actinobacteria	I	Methylmalonyl-CoA mutase	mutB	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
k59_596705_1	497964.CfE428DRAFT_3537	2.48e-59	198.0	COG0621@1|root,COG0621@2|Bacteria,46S6B@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_1306125_1	1267005.KB911255_gene2958	3.77e-126	392.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2TRQG@28211|Alphaproteobacteria,3N655@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
k59_655996_1	335543.Sfum_0147	1.4e-54	176.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,42RFN@68525|delta/epsilon subdivisions,2WP25@28221|Deltaproteobacteria,2MS0D@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_831802_1	1121405.dsmv_0205	3.89e-23	99.8	COG1480@1|root,COG1480@2|Bacteria,1NCY5@1224|Proteobacteria,42MI9@68525|delta/epsilon subdivisions,2WJI1@28221|Deltaproteobacteria,2MI01@213118|Desulfobacterales	28221|Deltaproteobacteria	S	metal-dependent phosphohydrolase 7TM intracellular region	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
k59_831802_2	868864.Dester_0670	6.24e-34	125.0	COG1702@1|root,COG1702@2|Bacteria,2G3S6@200783|Aquificae	200783|Aquificae	T	PFAM PhoH family protein	phoH	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_127693_1	1122201.AUAZ01000002_gene1134	1.47e-93	288.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,1RQA2@1236|Gammaproteobacteria,469GP@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_366743_1	472759.Nhal_0903	1.68e-116	360.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1WXI8@135613|Chromatiales	135613|Chromatiales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_1006435_1	926564.KI911583_gene317	7.28e-52	190.0	COG2720@1|root,COG2720@2|Bacteria,2GISH@201174|Actinobacteria,4F394@85017|Promicromonosporaceae	201174|Actinobacteria	V	VanW like protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,VanW
k59_1535790_2	991905.SL003B_0086	3.99e-38	135.0	COG3153@1|root,COG3153@2|Bacteria,1RHPP@1224|Proteobacteria,2U9DM@28211|Alphaproteobacteria,4BQZB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	ko:K03824	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_7,Acetyltransf_9
k59_1654240_1	1211815.CBYP010000045_gene787	1e-06	50.8	COG0463@1|root,COG0463@2|Bacteria,2I3C0@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1654240_2	1211815.CBYP010000045_gene785	5.07e-122	359.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	wbpD	-	-	-	-	-	-	-	-	-	-	-	FdtA,Hexapep,Hexapep_2
k59_1711974_1	675817.VDA_001033	4.15e-110	340.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,1XTUF@135623|Vibrionales	135623|Vibrionales	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_538309_1	743718.Isova_0384	6.87e-21	91.7	COG2223@1|root,COG2223@2|Bacteria,2I4E5@201174|Actinobacteria,4F4D7@85017|Promicromonosporaceae	201174|Actinobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_538309_2	367299.JOEE01000011_gene3138	5.67e-104	305.0	COG0640@1|root,COG0640@2|Bacteria,2IQKG@201174|Actinobacteria,4FG7S@85021|Intrasporangiaceae	201174|Actinobacteria	K	ArsR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
k59_1306148_1	765910.MARPU_16665	6.96e-09	57.8	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,1WWKS@135613|Chromatiales	135613|Chromatiales	M	Involved in formation and maintenance of cell shape	-	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
k59_305945_1	765910.MARPU_09100	6.03e-33	130.0	COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,1RN89@1236|Gammaproteobacteria,1WWQS@135613|Chromatiales	135613|Chromatiales	Q	PFAM Mammalian cell entry related	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_423414_1	1121405.dsmv_0763	9.98e-102	315.0	COG1328@1|root,COG1328@2|Bacteria,1MWMS@1224|Proteobacteria,42M8V@68525|delta/epsilon subdivisions,2WJ7S@28221|Deltaproteobacteria,2MHTW@213118|Desulfobacterales	28221|Deltaproteobacteria	F	anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
k59_1187231_1	523791.Kkor_2617	2.71e-50	172.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1XIPZ@135619|Oceanospirillales	135619|Oceanospirillales	S	protein containing LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_482189_2	396588.Tgr7_3010	3.34e-103	313.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1WWX1@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_130503_1	765913.ThidrDRAFT_1650	3.07e-36	135.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WXBN@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD linked oxidase domain protein	-	-	1.1.5.12	ko:K03777	ko00620,ko01120,map00620,map01120	-	R00704,R11591	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_130503_2	1123073.KB899241_gene3189	5.23e-11	62.4	COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,1RY2B@1236|Gammaproteobacteria,1X933@135614|Xanthomonadales	135614|Xanthomonadales	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
k59_1596981_1	420246.GTNG_1847	4.1e-32	124.0	COG2213@1|root,COG2213@2|Bacteria,1TPE3@1239|Firmicutes,4HAVV@91061|Bacilli,1WFWV@129337|Geobacillus	91061|Bacilli	G	PTS system, Lactose/Cellobiose specific IIB subunit	mtlA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563	2.7.1.197	ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	M00274	R02704	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5	-	-	PTS_EIIC,PTS_IIB
k59_1538620_1	713586.KB900536_gene1398	7.53e-23	100.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1X0EW@135613|Chromatiales	135613|Chromatiales	O	Trypsin	-	-	-	ko:K04691	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
k59_76918_1	694431.DESACE_07215	3.38e-81	251.0	COG2221@1|root,COG2221@2|Bacteria,1MVZQ@1224|Proteobacteria,42N7B@68525|delta/epsilon subdivisions,2WJYE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM sulfite reductase, dissimilatory-type beta subunit	dsrB	-	1.8.99.5	ko:K11181	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7,NIR_SIR,NIR_SIR_ferr
k59_717458_1	63737.Npun_F4004	2.9e-60	200.0	2BZ5C@1|root,33RFU@2|Bacteria,1GNQZ@1117|Cyanobacteria,1HRUW@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1596994_1	768671.ThimaDRAFT_0227	3.45e-68	228.0	COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,1RPD2@1236|Gammaproteobacteria,1WXID@135613|Chromatiales	135613|Chromatiales	S	doubled CXXCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Paired_CXXCH_1,TPR_19,TPR_8
k59_482208_1	1121405.dsmv_0661	1.19e-60	194.0	COG0517@1|root,COG0517@2|Bacteria,1PDG6@1224|Proteobacteria,42QQ0@68525|delta/epsilon subdivisions,2WMQ6@28221|Deltaproteobacteria,2MKN2@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM CBS domain	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
k59_658833_1	1121372.AULK01000003_gene289	4.76e-61	198.0	COG0438@1|root,COG0438@2|Bacteria,2HSB1@201174|Actinobacteria,4FMMD@85023|Microbacteriaceae	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
k59_658833_2	1121952.ATXT01000015_gene244	2.59e-20	89.4	COG1216@1|root,COG1216@2|Bacteria,2I6P4@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyltransferase WbsX	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_WbsX
k59_189754_1	391593.RCCS2_15804	2.24e-97	311.0	COG1038@1|root,COG1038@2|Bacteria,1NW9R@1224|Proteobacteria,2TQXU@28211|Alphaproteobacteria,2P2PX@2433|Roseobacter	28211|Alphaproteobacteria	C	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second	pyc	-	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA
k59_306520_1	224324.aq_1925	8.16e-52	179.0	COG0146@1|root,COG0146@2|Bacteria,2G3NG@200783|Aquificae	200783|Aquificae	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_77702_1	693986.MOC_3626	1.25e-71	226.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JXEF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_958536_1	1459636.NTE_01453	2.46e-16	77.4	arCOG05906@1|root,arCOG05906@2157|Archaea,41T21@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_22152_2	347834.RHE_CH02956	2.42e-14	70.1	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2U7DJ@28211|Alphaproteobacteria,4BF16@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Yqey-like protein	MA20_04985	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
k59_77705_1	979556.MTES_2077	1.55e-49	177.0	COG3345@1|root,COG3345@2|Bacteria,2GJJ1@201174|Actinobacteria,4FKWH@85023|Microbacteriaceae	201174|Actinobacteria	G	Melibiase	rafA	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
k59_659447_1	667014.Thein_1908	9.89e-13	68.6	COG2095@1|root,COG2095@2|Bacteria,2GHKM@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
k59_1422834_1	941449.dsx2_1820	1.29e-06	51.2	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,42N91@68525|delta/epsilon subdivisions,2WIMM@28221|Deltaproteobacteria,2M8Z2@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
k59_541591_2	1397696.KK211189_gene1112	3.03e-08	56.2	2CAAY@1|root,32RR1@2|Bacteria,1V8Y6@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1310716_2	1122599.AUGR01000021_gene3198	2.47e-09	54.7	COG1888@1|root,COG1888@2|Bacteria,1N92Y@1224|Proteobacteria,1SD5W@1236|Gammaproteobacteria,1XQPP@135619|Oceanospirillales	135619|Oceanospirillales	S	Uncharacterized ArCR, COG1888	-	-	-	-	-	-	-	-	-	-	-	-	DUF211
k59_424038_1	635013.TherJR_0856	4.66e-35	134.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,2604P@186807|Peptococcaceae	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_255743_1	446466.Cfla_0990	1.37e-51	169.0	COG1853@1|root,COG1853@2|Bacteria,2GMPH@201174|Actinobacteria	201174|Actinobacteria	K	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
k59_424039_1	977880.RALTA_B1421	1.59e-24	109.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2VMX9@28216|Betaproteobacteria,1K0PN@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_958566_1	1151122.AQYD01000007_gene665	1.09e-53	191.0	COG2911@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG4625@1|root,COG4932@1|root,COG5373@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,COG4625@2|Bacteria,COG4932@2|Bacteria,COG5373@2|Bacteria	2|Bacteria	KLT	membrane	-	-	-	ko:K02451,ko:K03832,ko:K13735,ko:K20276,ko:K21449	ko02024,ko05100,map02024,map05100	M00331	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	1.B.40.2,2.C.1.1,9.B.42	-	-	PATR,T2SSB
k59_1539266_2	323848.Nmul_A2660	1.09e-36	130.0	COG0737@1|root,COG0737@2|Bacteria,1RFNB@1224|Proteobacteria,2VR8M@28216|Betaproteobacteria,372HK@32003|Nitrosomonadales	28216|Betaproteobacteria	C	to Cytochrome c-554 precursor (C554) (Hydroxylamine oxidoreductase-linked cytochrome) pir A59036 cytochrome c554, tetraheme, precursor - Nitrosomonas europaea	-	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
k59_718043_1	1713.JOFV01000022_gene1705	8.35e-84	269.0	COG0620@1|root,COG0620@2|Bacteria,2GIXA@201174|Actinobacteria,4F11H@85016|Cellulomonadaceae	201174|Actinobacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	metE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0040007,GO:0042084,GO:0042085,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050667,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_1,Meth_synt_2
k59_1715130_1	2002.JOEQ01000005_gene3288	7.07e-23	102.0	COG0778@1|root,COG0778@2|Bacteria,2I97S@201174|Actinobacteria,4EP0F@85012|Streptosporangiales	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_1715131_2	880072.Desac_0272	2.38e-43	145.0	COG1342@1|root,COG1342@2|Bacteria,1N80T@1224|Proteobacteria,42TAM@68525|delta/epsilon subdivisions,2WP9H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function  DUF134	-	-	-	-	-	-	-	-	-	-	-	-	DUF134
k59_22193_1	582402.Hbal_2020	1.02e-33	131.0	COG0189@1|root,COG4067@1|root,COG0189@2|Bacteria,COG4067@2|Bacteria,1MX62@1224|Proteobacteria,2TRUH@28211|Alphaproteobacteria,43W5H@69657|Hyphomonadaceae	28211|Alphaproteobacteria	HJO	Belongs to the RimK family	rimK	-	6.3.2.32	ko:K05844,ko:K14940	ko00680,ko01120,map00680,map01120	-	R09401	RC00064,RC00090	ko00000,ko00001,ko01000,ko03009	-	-	-	RimK,Zn_protease
k59_1422862_1	936155.HFELIS_08460	3.09e-18	84.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,42NAR@68525|delta/epsilon subdivisions,2YN6R@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_1422862_2	335543.Sfum_0202	9.16e-30	114.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria,2MQ5T@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	1.6.5.3	ko:K00333,ko:K13378,ko:K13380	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
k59_1075088_1	1449058.JQKT01000007_gene1542	2.99e-105	323.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GMMM@201174|Actinobacteria,4FKFA@85023|Microbacteriaceae	201174|Actinobacteria	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_1773607_1	1304865.JAGF01000001_gene754	1.9e-77	253.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria,4F0E3@85016|Cellulomonadaceae	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1009210_1	644282.Deba_2616	1.82e-40	152.0	COG2202@1|root,COG2204@1|root,COG3852@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG3852@2|Bacteria,1NWNJ@1224|Proteobacteria,43BNW@68525|delta/epsilon subdivisions,2X7Z8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
k59_1484837_1	1408473.JHXO01000001_gene2242	2.93e-30	122.0	COG4219@1|root,COG4219@2|Bacteria,4PKZS@976|Bacteroidetes,2G096@200643|Bacteroidia	976|Bacteroidetes	KT	Gliding motility-associated protein GldM	gldM	-	-	-	-	-	-	-	-	-	-	-	GldM_C,GldM_N
k59_659481_1	768671.ThimaDRAFT_4347	3.21e-102	304.0	COG0583@1|root,COG0583@2|Bacteria,1MVHT@1224|Proteobacteria,1RN7G@1236|Gammaproteobacteria,1WXTT@135613|Chromatiales	135613|Chromatiales	K	PFAM HTH transcriptional regulator, LysR	-	-	-	ko:K03717	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_835232_1	1415780.JPOG01000001_gene548	2.1e-93	299.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1X4SH@135614|Xanthomonadales	135614|Xanthomonadales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1126800_1	649831.L083_3369	5.5e-47	167.0	2EAEX@1|root,334ID@2|Bacteria,2H5WX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_22202_2	1172188.KB911831_gene4031	2.01e-08	55.1	COG0745@1|root,COG0745@2|Bacteria,2GN73@201174|Actinobacteria,4FFGM@85021|Intrasporangiaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_22202_3	1172188.KB911827_gene4348	1.55e-15	75.5	2DBEB@1|root,32TXC@2|Bacteria,2IRDQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_899601_1	1170562.Cal6303_1722	8.68e-31	123.0	COG0531@1|root,COG0531@2|Bacteria,1G2GM@1117|Cyanobacteria,1HJCQ@1161|Nostocales	1117|Cyanobacteria	E	PFAM Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_1715151_1	1157490.EL26_00550	8.74e-13	73.2	COG0155@1|root,COG0155@2|Bacteria,1TS58@1239|Firmicutes,4HBEX@91061|Bacilli,278SJ@186823|Alicyclobacillaceae	91061|Bacilli	P	Nitrite/Sulfite reductase ferredoxin-like half domain	nirA	-	1.7.7.1	ko:K00366	ko00910,ko01120,map00910,map01120	M00531	R00790	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_835240_1	1267005.KB911260_gene3395	1.43e-55	194.0	COG2312@1|root,COG2518@1|root,COG2312@2|Bacteria,COG2518@2|Bacteria,1MU2S@1224|Proteobacteria,2TWB5@28211|Alphaproteobacteria,3N9HZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	Erythro_esteras,PCMT,Pribosyltran
k59_774287_1	1026882.MAMP_01350	4.36e-111	348.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,4606D@72273|Thiotrichales	72273|Thiotrichales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_835243_1	1095767.CAHD01000142_gene2239	1.35e-139	445.0	COG0366@1|root,COG1523@1|root,COG0366@2|Bacteria,COG1523@2|Bacteria,2GKK1@201174|Actinobacteria,4F10I@85016|Cellulomonadaceae	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Alpha-amylase_C,CBM_48,DUF3372
k59_1657719_1	1045855.DSC_14995	1.49e-83	277.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1X341@135614|Xanthomonadales	135614|Xanthomonadales	Q	ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_77808_1	933262.AXAM01000053_gene2701	0.000656	42.7	COG3008@1|root,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,42PHS@68525|delta/epsilon subdivisions,2X5NU@28221|Deltaproteobacteria,2MMH1@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	MlaD protein	-	-	-	-	-	-	-	-	-	-	-	-	MlaD
k59_77808_2	631362.Thi970DRAFT_00760	3.16e-43	154.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,1RM9Z@1236|Gammaproteobacteria,1WX87@135613|Chromatiales	135613|Chromatiales	S	PFAM Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_1187940_1	768671.ThimaDRAFT_3893	1.96e-134	406.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales	135613|Chromatiales	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_1009240_1	388051.AUFE01000011_gene5318	4.28e-65	215.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,1K152@119060|Burkholderiaceae	28216|Betaproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_189839_1	935548.KI912159_gene5601	3.97e-36	125.0	2AFVV@1|root,315YK@2|Bacteria,1NQAN@1224|Proteobacteria,2UNGW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_659518_1	1415779.JOMH01000001_gene1841	3.57e-27	118.0	COG0664@1|root,COG1033@1|root,COG0664@2|Bacteria,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1X3P5@135614|Xanthomonadales	135614|Xanthomonadales	T	Sterol-sensing domain of SREBP cleavage-activation	-	-	-	-	-	-	-	-	-	-	-	-	MMPL,cNMP_binding
k59_1363312_1	1193181.BN10_1130015	1.02e-124	369.0	COG0464@1|root,COG0464@2|Bacteria,2GJWA@201174|Actinobacteria,4FEFU@85021|Intrasporangiaceae	201174|Actinobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_1715183_1	1385521.N803_03865	2.24e-07	56.6	COG0215@1|root,COG0215@2|Bacteria,2GJF2@201174|Actinobacteria,4FECH@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
k59_1715183_2	1231241.Mc24_05285	1.46e-09	59.3	COG1117@1|root,COG1117@2|Bacteria,2GC97@200918|Thermotogae	200918|Thermotogae	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	iLJ478.TM1261	ABC_tran
k59_1773651_1	768671.ThimaDRAFT_1160	2.67e-105	333.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1WVW8@135613|Chromatiales	135613|Chromatiales	EF	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_1539319_1	292415.Tbd_0670	1.03e-24	102.0	COG2197@1|root,COG2197@2|Bacteria,1N8MU@1224|Proteobacteria,2VV2P@28216|Betaproteobacteria	28216|Betaproteobacteria	K	luxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_835266_1	765913.ThidrDRAFT_4467	2.27e-190	562.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WXV4@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_1597675_1	472759.Nhal_0237	1.72e-47	167.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,1RMHK@1236|Gammaproteobacteria,1X1NE@135613|Chromatiales	135613|Chromatiales	L	transposase IS4	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_131225_1	522306.CAP2UW1_2438	4.99e-81	268.0	COG4196@1|root,COG4196@2|Bacteria,1R6II@1224|Proteobacteria,2WHVK@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Putative amidoligase enzyme (DUF2126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2126
k59_131225_2	870187.Thini_0202	2.82e-44	154.0	COG1305@1|root,COG1305@2|Bacteria,1MVAG@1224|Proteobacteria,1RMXM@1236|Gammaproteobacteria,463S1@72273|Thiotrichales	72273|Thiotrichales	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_1539321_1	742735.HMPREF9467_02636	4.09e-52	186.0	COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,21XIQ@1506553|Lachnoclostridium	186801|Clostridia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_1773656_1	1499967.BAYZ01000016_gene6509	1.77e-53	189.0	COG5009@1|root,COG5009@2|Bacteria,2NS4K@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase	mrcA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
k59_189853_1	76114.ebA880	1.34e-66	206.0	COG1522@1|root,COG1522@2|Bacteria,1RIKY@1224|Proteobacteria,2VSBM@28216|Betaproteobacteria,2KWF6@206389|Rhodocyclales	206389|Rhodocyclales	K	overlaps another CDS with the same product name	nirG	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
k59_1075188_1	1276756.AUEX01000005_gene2751	1.4e-19	85.1	COG3631@1|root,COG3631@2|Bacteria,1MZS5@1224|Proteobacteria,2VSD2@28216|Betaproteobacteria,4AJYT@80864|Comamonadaceae	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	5.3.3.1	ko:K01822	ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120	M00107,M00110	R01837,R02216,R02499,R02840,R03327,R04163,R04678,R04849,R09955	RC00146,RC00762	ko00000,ko00001,ko00002,ko01000	-	-	-	SnoaL_2
k59_774317_1	987059.RBXJA2T_01115	1.01e-103	308.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2W0NK@28216|Betaproteobacteria,1KKHF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_835278_2	935839.JAGJ01000004_gene1926	1.3e-50	164.0	COG2146@1|root,COG2146@2|Bacteria,2IQM4@201174|Actinobacteria,4F4V4@85017|Promicromonosporaceae	201174|Actinobacteria	P	Rieske-like [2Fe-2S] domain	nirD	-	1.7.1.15	ko:K00363	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske_2
k59_131235_1	887062.HGR_10645	1.63e-49	164.0	COG1225@1|root,COG1225@2|Bacteria,1RH4P@1224|Proteobacteria,2VT1P@28216|Betaproteobacteria	28216|Betaproteobacteria	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_1075209_1	1279017.AQYJ01000024_gene1084	2.95e-106	316.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,465NF@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105	Glycos_transf_4,MraY_sig1
k59_1422944_1	314285.KT71_06262	4.96e-19	90.1	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1RWT7@1236|Gammaproteobacteria,1JBPX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1363340_1	2340.JV46_14280	3.32e-89	275.0	COG1156@1|root,COG1156@2|Bacteria,1QUQE@1224|Proteobacteria,1T210@1236|Gammaproteobacteria,1JC0C@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_ab
k59_1249927_1	411489.CLOL250_00551	7.65e-13	68.9	COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,247MF@186801|Clostridia,36DGQ@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_1249927_2	717606.PaecuDRAFT_3368	3.01e-21	90.5	COG1438@1|root,COG1438@2|Bacteria,1V1R7@1239|Firmicutes,4HFY8@91061|Bacilli,26X0G@186822|Paenibacillaceae	91061|Bacilli	K	Regulates arginine biosynthesis genes	argR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006355,GO:0006520,GO:0006525,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901605,GO:1903506,GO:2000112,GO:2001141	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
k59_1422946_1	1219035.NT2_27_00020	3.6e-11	68.6	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,2K503@204457|Sphingomonadales	204457|Sphingomonadales	L	PFAM Transposase IS116 IS110 IS902 family, Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1484935_1	159087.Daro_3824	7.98e-17	80.1	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2VIE4@28216|Betaproteobacteria,2M02H@206389|Rhodocyclales	206389|Rhodocyclales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1484935_2	1268068.PG5_44800	4.29e-28	114.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1S01K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1715210_1	255470.cbdbA1077	4.04e-99	319.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,2G5QB@200795|Chloroflexi	200795|Chloroflexi	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1126862_1	1122194.AUHU01000003_gene2367	5.36e-17	84.7	COG4733@1|root,COG4733@2|Bacteria,1R55I@1224|Proteobacteria,1S5X2@1236|Gammaproteobacteria,468S7@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1014214_1	396014.BF93_02105	5.81e-13	67.4	COG0824@1|root,COG0824@2|Bacteria,2IFAK@201174|Actinobacteria,4FCST@85020|Dermabacteraceae	201174|Actinobacteria	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
k59_1014214_2	1229781.C272_02190	5.09e-38	139.0	COG0488@1|root,COG0488@2|Bacteria,2GKBQ@201174|Actinobacteria,4F8HT@85019|Brevibacteriaceae	201174|Actinobacteria	S	ABC transporter	yjjK	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
k59_1083298_1	1388763.O165_006040	5.35e-17	77.4	COG2153@1|root,COG2153@2|Bacteria,1MZ86@1224|Proteobacteria,1S8SK@1236|Gammaproteobacteria,1YVGB@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	PFAM GCN5-related N-acetyltransferase	yjcF	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
k59_1083298_2	1049564.TevJSym_ad01320	2.03e-95	293.0	COG2850@1|root,COG2850@2|Bacteria,1MW30@1224|Proteobacteria,1RN2Q@1236|Gammaproteobacteria,1J5M2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	A domain family that is part of the cupin metalloenzyme superfamily.	ycfD	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016491,GO:0016705,GO:0016706,GO:0018193,GO:0018195,GO:0019538,GO:0030961,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:1901564	1.14.11.47	ko:K18850	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Cupin_4
k59_264534_1	562973.HMPREF0059_00915	2.35e-62	200.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4D411@85005|Actinomycetales	201174|Actinobacteria	KT	response regulator	tcrX	GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0098771	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1779790_1	997296.PB1_13764	7.89e-43	158.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,4HA3G@91061|Bacilli,1ZAVY@1386|Bacillus	91061|Bacilli	T	Diguanylate cyclase	gmr	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_8,PAS_9
k59_841146_1	1026882.MAMP_01041	3.62e-54	179.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,1RMAE@1236|Gammaproteobacteria,460E4@72273|Thiotrichales	72273|Thiotrichales	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
k59_1492004_1	977880.RALTA_A2814	9.26e-67	217.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,1K24M@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23,OmpA
k59_1847342_1	1415780.JPOG01000001_gene2437	3.83e-122	379.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1X32B@135614|Xanthomonadales	135614|Xanthomonadales	P	COG2217 Cation transport ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_488764_1	713586.KB900536_gene2207	3.64e-108	328.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	lpdG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iE2348C_1286.E2348C_4372,iJN746.PP_4187	Pyr_redox_2,Pyr_redox_dim
k59_379694_1	1125863.JAFN01000001_gene3206	3.81e-119	357.0	COG2159@1|root,COG2159@2|Bacteria,1QZ3W@1224|Proteobacteria,42PKB@68525|delta/epsilon subdivisions,2WM59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_312809_1	228410.NE1856	1.13e-15	81.6	COG0699@1|root,COG0699@2|Bacteria,1MV59@1224|Proteobacteria,2WB2P@28216|Betaproteobacteria,3724Z@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_1492022_2	313589.JNB_17838	1.58e-57	180.0	COG1695@1|root,COG1695@2|Bacteria,2GRHC@201174|Actinobacteria,4FH26@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
k59_841177_1	1121374.KB891586_gene2762	9.95e-40	146.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RYHN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents permease component	mlaE_1	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS_2
k59_665400_1	367299.JOEE01000004_gene1020	7.55e-188	529.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4FE3A@85021|Intrasporangiaceae	201174|Actinobacteria	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	fadA4	GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0044464,GO:0046395,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:0075136,GO:1901575	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_841178_1	1380354.JIAN01000005_gene2543	1.7e-53	183.0	COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria,4F15H@85016|Cellulomonadaceae	201174|Actinobacteria	H	PFAM MoeA domain protein domain I and II	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_1847374_1	1380394.JADL01000001_gene2823	3.2e-33	130.0	COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,2U1JN@28211|Alphaproteobacteria,2JS8K@204441|Rhodospirillales	204441|Rhodospirillales	Q	MlaD protein	-	-	-	ko:K02067,ko:K06192	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_86192_1	1321775.HMPREF1980_01164	4.34e-31	123.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4D41S@85005|Actinomycetales	201174|Actinobacteria	I	AMP-binding enzyme	fadD3	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_86192_2	1095767.CAHD01000231_gene2903	1.36e-22	89.4	COG1605@1|root,COG1605@2|Bacteria,2IQ46@201174|Actinobacteria,4F1FN@85016|Cellulomonadaceae	201174|Actinobacteria	E	PFAM Chorismate mutase, type II	tyrA	-	5.4.99.5	ko:K04092	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2
k59_1083345_1	930171.Asphe3_39780	4.13e-77	236.0	COG2085@1|root,COG2085@2|Bacteria,2GMZ5@201174|Actinobacteria	201174|Actinobacteria	S	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
k59_1083345_2	1120949.KB903320_gene2942	4.93e-51	167.0	COG3226@1|root,COG3226@2|Bacteria,2HUE7@201174|Actinobacteria,4DFXY@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
k59_1779828_1	682795.AciX8_4155	3.49e-57	199.0	COG3533@1|root,COG3533@2|Bacteria,3Y3WA@57723|Acidobacteria,2JKD6@204432|Acidobacteriia	204432|Acidobacteriia	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
k59_379731_1	519989.ECTPHS_08246	2.67e-77	242.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1WWFA@135613|Chromatiales	135613|Chromatiales	E	PFAM Prephenate dehydratase	-	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
k59_379731_2	1049564.TevJSym_ad01420	3.37e-67	216.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,1J5JA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_665410_1	1123065.ATWL01000010_gene2995	8.82e-157	454.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria	201174|Actinobacteria	D	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_723817_1	743299.Acife_2037	1.75e-09	63.9	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,2NCQE@225057|Acidithiobacillales	225057|Acidithiobacillales	M	Mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
k59_723818_1	207559.Dde_1444	3.31e-66	214.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,42NJ3@68525|delta/epsilon subdivisions,2WKHX@28221|Deltaproteobacteria,2M8BV@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	PFAM SufBD protein	-	-	-	ko:K07033	-	-	-	-	ko00000	-	-	-	UPF0051
k59_1492040_1	644801.Psest_0518	2.25e-75	233.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1Z20I@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048519,GO:0050789,GO:0051186,GO:0051188,GO:0051604,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	iECSF_1327.ECSF_0569,iSFV_1184.SFV_0696,iSFxv_1172.SFxv_0718	BPL_LplA_LipB
k59_1492040_2	391615.ABSJ01000022_gene310	2.62e-89	271.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1J5F5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_1132406_1	1304865.JAGF01000001_gene436	1.36e-57	189.0	COG1716@1|root,COG1716@2|Bacteria,2GK5I@201174|Actinobacteria,4F1PK@85016|Cellulomonadaceae	201174|Actinobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
k59_1369363_1	1121878.AUGL01000009_gene3375	3.42e-73	238.0	COG1028@1|root,COG3173@1|root,COG1028@2|Bacteria,COG3173@2|Bacteria,1MWGC@1224|Proteobacteria,1RRE1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	HA62_15005	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1779840_1	713586.KB900536_gene2052	1.35e-39	144.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1WX2U@135613|Chromatiales	135613|Chromatiales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_264603_1	991905.SL003B_1216	1.76e-53	180.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,2TST5@28211|Alphaproteobacteria,4BRH5@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_30731_1	713586.KB900536_gene1579	2.51e-98	296.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1WWWF@135613|Chromatiales	135613|Chromatiales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_1193935_1	765912.Thimo_2040	3.95e-90	282.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales	135613|Chromatiales	I	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_430017_1	1121918.ARWE01000001_gene2976	2.41e-70	219.0	COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,42Q8Q@68525|delta/epsilon subdivisions,2WMKQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_195773_1	933262.AXAM01000034_gene1563	1.38e-27	114.0	COG2885@1|root,COG3267@1|root,COG2885@2|Bacteria,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,42PJ3@68525|delta/epsilon subdivisions,2WJF6@28221|Deltaproteobacteria,2MJ4S@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	AAA domain	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,OmpA
k59_195778_1	1123065.ATWL01000002_gene1679	2.67e-110	326.0	COG0052@1|root,COG0052@2|Bacteria,2GMYC@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_30754_1	211114.JOEF01000001_gene7080	1.73e-90	277.0	COG1760@1|root,COG1760@2|Bacteria,2GJPA@201174|Actinobacteria,4DY5U@85010|Pseudonocardiales	201174|Actinobacteria	E	Serine dehydratase beta chain	sdaA	GO:0003674,GO:0003824,GO:0003941,GO:0016829,GO:0016840,GO:0016841	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha,SDH_beta
k59_1847426_1	997346.HMPREF9374_1697	1.39e-15	82.0	COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,4HASP@91061|Bacilli,27DAR@186824|Thermoactinomycetaceae	91061|Bacilli	P	MgtE intracellular N domain	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	iYO844.BSU13300	CBS,MgtE,MgtE_N
k59_264635_1	1035308.AQYY01000002_gene638	1.47e-57	186.0	COG3449@1|root,COG3449@2|Bacteria,1V4SC@1239|Firmicutes,24RPG@186801|Clostridia	186801|Clostridia	L	SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
k59_379785_1	1187848.AJYQ01000008_gene535	1.43e-62	206.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,1RQ31@1236|Gammaproteobacteria,1XV2J@135623|Vibrionales	135623|Vibrionales	E	COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_1847430_1	998674.ATTE01000001_gene824	7.97e-46	160.0	COG0477@1|root,COG2814@2|Bacteria,1N2NP@1224|Proteobacteria,1RP1Y@1236|Gammaproteobacteria,4622I@72273|Thiotrichales	72273|Thiotrichales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1132429_1	446469.Sked_29250	1.4e-113	340.0	COG0787@1|root,COG0787@2|Bacteria,2GM2Y@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_1369384_1	458817.Shal_2302	1.73e-68	214.0	COG2176@1|root,COG2176@2|Bacteria,1QUVW@1224|Proteobacteria,1RM8J@1236|Gammaproteobacteria,2Q9N8@267890|Shewanellaceae	1236|Gammaproteobacteria	L	PFAM Exonuclease, RNase T and DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_606813_2	1223521.BBJX01000010_gene72	3.69e-17	80.9	29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,2VR98@28216|Betaproteobacteria,4AE7P@80864|Comamonadaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4390)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4390
k59_1320341_1	1380354.JIAN01000008_gene3319	1.69e-102	301.0	COG0500@1|root,COG2226@2|Bacteria,2GJSF@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_32085_1	1123024.AUII01000016_gene1311	4.09e-37	145.0	COG1330@1|root,COG1330@2|Bacteria,2GNVB@201174|Actinobacteria,4E8FA@85010|Pseudonocardiales	201174|Actinobacteria	L	Exodeoxyribonuclease V, gamma subunit	recC	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
k59_841976_1	883169.HMPREF9719_00259	3.11e-20	92.4	COG0770@1|root,COG0770@2|Bacteria,2GK0Y@201174|Actinobacteria,22KRC@1653|Corynebacteriaceae	201174|Actinobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	GO:0008150,GO:0040007	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_841976_2	1454010.JEOE01000006_gene2117	4.34e-151	441.0	COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria,4F0FZ@85016|Cellulomonadaceae	201174|Actinobacteria	M	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2158c	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_430762_1	626887.J057_06971	7.45e-59	199.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria,465X3@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	COG1030 Membrane-bound serine protease (ClpP class)	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
k59_87287_1	525246.HMPREF0058_1788	7.92e-69	228.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4D3VH@85005|Actinomycetales	201174|Actinobacteria	IQ	cog cog0318	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_841983_1	335543.Sfum_4025	8.59e-108	328.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1NR3M@1224|Proteobacteria,42N3G@68525|delta/epsilon subdivisions,2WIS9@28221|Deltaproteobacteria,2MRA2@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
k59_87299_1	1380354.JIAN01000005_gene2925	4.93e-45	169.0	COG3225@1|root,COG3225@2|Bacteria,2GMTX@201174|Actinobacteria,4F0K8@85016|Cellulomonadaceae	201174|Actinobacteria	N	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1084335_1	1380370.JIBA01000013_gene1413	4.3e-132	396.0	COG0366@1|root,COG0366@2|Bacteria,2GKT9@201174|Actinobacteria,4FEVJ@85021|Intrasporangiaceae	201174|Actinobacteria	G	Alpha amylase, catalytic domain	ams	-	2.4.1.4	ko:K05341	ko00500,map00500	-	R01823	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
k59_380874_1	1415778.JQMM01000001_gene1113	4.79e-64	220.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5F8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1014964_1	1122135.KB893134_gene3780	6.04e-81	254.0	COG3676@1|root,COG3677@1|root,COG3676@2|Bacteria,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,2TQR3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_87303_1	1122603.ATVI01000010_gene969	6.74e-35	129.0	COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria,1X5IM@135614|Xanthomonadales	135614|Xanthomonadales	NU	type IV pilus biogenesis stability protein PilW	pilF	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	TPR_10,TPR_16,TPR_17,TPR_2,TPR_6,TPR_8
k59_1546033_1	697282.Mettu_2592	5.59e-183	516.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,1RYPY@1236|Gammaproteobacteria,1XETG@135618|Methylococcales	1236|Gammaproteobacteria	S	PFAM Transposase, IS801 IS1294	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_1546033_2	1366050.N234_36435	3.08e-89	270.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VNSH@28216|Betaproteobacteria,1KGQD@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_1722115_1	1365176.N186_04310	3.15e-80	266.0	COG0574@1|root,arCOG01111@2157|Archaea,2XPWQ@28889|Crenarchaeota	28889|Crenarchaeota	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_548154_1	1385520.N802_14135	4.73e-39	132.0	COG1522@1|root,COG1522@2|Bacteria,2IQD4@201174|Actinobacteria,4FHCX@85021|Intrasporangiaceae	201174|Actinobacteria	K	AsnC family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
k59_548154_2	446469.Sked_15730	1.33e-41	148.0	COG0547@1|root,COG0547@2|Bacteria,2GM4G@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
k59_842006_1	1261545.MBE-HAL_0957	5.44e-06	53.5	COG1574@1|root,arCOG00691@2157|Archaea,2XUUZ@28890|Euryarchaeota,23SFX@183963|Halobacteria	183963|Halobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1780627_1	631362.Thi970DRAFT_03296	2.47e-107	315.0	COG3267@1|root,COG3267@2|Bacteria,1REWJ@1224|Proteobacteria,1S518@1236|Gammaproteobacteria,1X0QD@135613|Chromatiales	1236|Gammaproteobacteria	U	Type II secretory pathway, component ExeA	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
k59_666190_1	768671.ThimaDRAFT_3360	1.15e-160	462.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1WW1X@135613|Chromatiales	135613|Chromatiales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
k59_1664703_1	1906.SFRA_06165	8.49e-09	57.4	COG1670@1|root,COG1670@2|Bacteria,2IHXG@201174|Actinobacteria	201174|Actinobacteria	J	Acetyltransferases including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_1664703_2	1198452.Jab_1c21690	7.32e-16	80.1	COG3164@1|root,COG3164@2|Bacteria,1QUYX@1224|Proteobacteria,2WGM2@28216|Betaproteobacteria,4791K@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
k59_32152_1	572477.Alvin_0607	1.01e-43	149.0	COG1011@1|root,COG1011@2|Bacteria,1NH15@1224|Proteobacteria,1RP27@1236|Gammaproteobacteria,1WW6W@135613|Chromatiales	135613|Chromatiales	E	subfamily IA, variant 3	-	-	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD,HAD_2,Hydrolase
k59_32152_2	388739.RSK20926_08222	1.35e-05	47.4	COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,2TT7B@28211|Alphaproteobacteria,2P1C3@2433|Roseobacter	28211|Alphaproteobacteria	P	COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase	cysQ	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
k59_380904_2	690850.Desaf_3195	8.54e-33	129.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,42P4T@68525|delta/epsilon subdivisions,2WKBS@28221|Deltaproteobacteria,2M8DW@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
k59_1493068_1	1380370.JIBA01000013_gene1329	8.65e-42	152.0	COG0025@1|root,COG0025@2|Bacteria,2I37Q@201174|Actinobacteria,4FFGA@85021|Intrasporangiaceae	201174|Actinobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1664705_1	258594.RPA0374	1.61e-105	314.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTI9@28211|Alphaproteobacteria,3JVVV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_606855_1	367299.JOEE01000001_gene2062	9.49e-96	287.0	COG0142@1|root,COG0142@2|Bacteria,2GMB4@201174|Actinobacteria,4FE3E@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	hepT	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_265933_1	1123023.JIAI01000033_gene4187	4.24e-55	184.0	COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria,4E0VQ@85010|Pseudonocardiales	201174|Actinobacteria	S	alcohol dehydrogenase	adhA	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1133228_1	497964.CfE428DRAFT_6336	9.81e-31	124.0	COG1480@1|root,COG1480@2|Bacteria,46S4P@74201|Verrucomicrobia	74201|Verrucomicrobia	S	7TM receptor with intracellular HD hydrolase	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,HD
k59_1664706_1	446466.Cfla_0921	6.39e-77	238.0	COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria,4F0GT@85016|Cellulomonadaceae	201174|Actinobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1780631_1	395494.Galf_2867	1.65e-84	267.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,44VMC@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	pap	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_430808_2	1209989.TepiRe1_1659	9.32e-06	48.5	COG1595@1|root,COG1595@2|Bacteria,1VFMV@1239|Firmicutes,24SAQ@186801|Clostridia,42IJI@68295|Thermoanaerobacterales	186801|Clostridia	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1014990_1	460265.Mnod_0281	1.48e-20	95.5	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2U3XH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF839,HemolysinCabind
k59_780101_1	1078020.KEK_05842	4.19e-35	134.0	COG0277@1|root,COG0277@2|Bacteria,2GIS6@201174|Actinobacteria,232UQ@1762|Mycobacteriaceae	201174|Actinobacteria	C	FAD linked	eapA	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_96895_1	1267005.KB911260_gene3435	1.06e-86	263.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2TTIX@28211|Alphaproteobacteria,3N6HE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_729936_1	384765.SIAM614_02591	3.46e-57	196.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_553575_1	983920.Y88_1520	2.08e-34	126.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2TRNR@28211|Alphaproteobacteria,2K1ES@204457|Sphingomonadales	204457|Sphingomonadales	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
k59_553575_2	247633.GP2143_10352	1.71e-37	132.0	COG1047@1|root,COG1047@2|Bacteria,1RHD1@1224|Proteobacteria,1S5YP@1236|Gammaproteobacteria,1J66I@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2	fkpB	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0061077,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K03774	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
k59_40257_1	1121405.dsmv_3138	1.18e-63	217.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria,2MIBK@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_96908_1	93220.LV28_06265	2.71e-82	261.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria,1K04M@119060|Burkholderiaceae	28216|Betaproteobacteria	I	PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_784656_1	1408419.JHYG01000018_gene1218	3.46e-15	75.5	COG0398@1|root,COG0398@2|Bacteria,1RDYV@1224|Proteobacteria,2U7GT@28211|Alphaproteobacteria,2JSDS@204441|Rhodospirillales	204441|Rhodospirillales	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_784656_2	292415.Tbd_1534	3.95e-111	344.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria,1KRDI@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_918684_1	290318.Cvib_0235	2.48e-09	58.5	COG1216@1|root,COG1216@2|Bacteria,1FEN2@1090|Chlorobi	1090|Chlorobi	M	PFAM glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
k59_672286_1	446466.Cfla_1539	1.45e-15	72.0	COG1396@1|root,COG1396@2|Bacteria,2GR3F@201174|Actinobacteria,4F1HP@85016|Cellulomonadaceae	201174|Actinobacteria	K	transcriptional	clgR	GO:0002682,GO:0002683,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006109,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009268,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009894,GO:0009987,GO:0010447,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0010675,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0022611,GO:0030162,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031347,GO:0031348,GO:0032268,GO:0032502,GO:0033554,GO:0035821,GO:0040007,GO:0042176,GO:0043207,GO:0043565,GO:0043620,GO:0044003,GO:0044110,GO:0044111,GO:0044114,GO:0044115,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051252,GO:0051254,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060255,GO:0061136,GO:0062012,GO:0065007,GO:0075136,GO:0080090,GO:0080134,GO:0085016,GO:0090062,GO:0097159,GO:1901363,GO:1902680,GO:1902882,GO:1903050,GO:1903362,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	HTH_31
k59_672286_2	471853.Bcav_2454	1.49e-37	134.0	COG0266@1|root,COG0266@2|Bacteria,2GKCW@201174|Actinobacteria	201174|Actinobacteria	L	Glycosylase	nei	-	4.2.99.18	ko:K05522	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_554386_1	408672.NBCG_02518	9.8e-165	483.0	COG3345@1|root,COG3345@2|Bacteria,2GJJ1@201174|Actinobacteria,4DSZC@85009|Propionibacteriales	201174|Actinobacteria	G	Glycosyl hydrolase family 36 N-terminal domain	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
k59_848203_1	502025.Hoch_2126	7.93e-56	192.0	COG2866@1|root,COG2866@2|Bacteria,1R586@1224|Proteobacteria,433ZT@68525|delta/epsilon subdivisions,2X4AT@28221|Deltaproteobacteria,2YYMP@29|Myxococcales	28221|Deltaproteobacteria	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_554388_1	768671.ThimaDRAFT_4125	4.67e-21	90.1	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1WWG5@135613|Chromatiales	135613|Chromatiales	V	pfam abc	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1785960_1	504832.OCAR_6617	4.73e-122	372.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,3JR76@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	penicillin-binding protein	pbp	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
k59_495767_2	1349820.M707_07855	1.68e-186	533.0	COG3356@1|root,COG3356@2|Bacteria,2IP4G@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Neutral alkaline nonlysosomal ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
k59_202574_1	1499967.BAYZ01000004_gene4922	3.63e-06	54.3	28M0D@1|root,2ZAFE@2|Bacteria	2|Bacteria	S	Putative ATP-binding cassette	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran_2
k59_98319_1	1123258.AQXZ01000019_gene2903	1.27e-50	163.0	COG3651@1|root,COG3651@2|Bacteria,2IHNI@201174|Actinobacteria,4G0HJ@85025|Nocardiaceae	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2237)	-	-	-	ko:K09966	-	-	-	-	ko00000	-	-	-	DUF2237
k59_1331442_1	1485544.JQKP01000004_gene562	1.07e-139	405.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,2VI9A@28216|Betaproteobacteria,44V37@713636|Nitrosomonadales	28216|Betaproteobacteria	H	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
k59_1331442_2	1112217.PPL19_03475	3.63e-16	79.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	ykoW	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9
k59_613058_1	765913.ThidrDRAFT_2502	6.01e-71	224.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,1WXW8@135613|Chromatiales	135613|Chromatiales	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
k59_202587_1	710111.FraQA3DRAFT_5363	1.23e-35	138.0	COG2252@1|root,COG2252@2|Bacteria,2IC5Y@201174|Actinobacteria,4ES8D@85013|Frankiales	201174|Actinobacteria	S	PFAM Xanthine uracil vitamin C permease	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	-
k59_730849_1	118797.XP_007468251.1	8.61e-100	325.0	COG0085@1|root,KOG0214@2759|Eukaryota	2759|Eukaryota	K	DNA-directed 5'-3' RNA polymerase activity	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0030880,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043,ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_672299_1	765912.Thimo_2826	1.64e-22	88.2	COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,1WZBU@135613|Chromatiales	135613|Chromatiales	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
k59_672299_2	521719.ATXQ01000002_gene2661	2.1e-74	227.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,1S4E6@1236|Gammaproteobacteria,1YEZY@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
k59_672299_3	1049564.TevJSym_ad00070	5.28e-107	327.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1J4XI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_1859748_2	384676.PSEEN1485	2.71e-07	55.1	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31,3.5.4.32	ko:K12960,ko:K18456	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_144049_1	1439940.BAY1663_00898	2.16e-50	181.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1SYH1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_320021_1	331678.Cphamn1_2485	1.64e-33	126.0	COG0180@1|root,COG0180@2|Bacteria,1FE4Z@1090|Chlorobi	1090|Chlorobi	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_320021_2	1123252.ATZF01000010_gene417	1.32e-05	46.6	COG1495@1|root,COG1495@2|Bacteria,1V79S@1239|Firmicutes,4HIKP@91061|Bacilli,27C7P@186824|Thermoactinomycetaceae	91061|Bacilli	O	Required for disulfide bond formation in some proteins	bdbC	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
k59_1201031_1	566466.NOR53_3472	9.34e-88	267.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1J7KQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus	gpsA	-	-	-	-	-	-	-	-	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_320025_1	933262.AXAM01000009_gene1490	4.2e-137	398.0	COG1148@1|root,COG1148@2|Bacteria,1Q0ZF@1224|Proteobacteria,42NHH@68525|delta/epsilon subdivisions,2WJ6M@28221|Deltaproteobacteria,2MIS1@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD dependent oxidoreductase	qmoA	-	-	ko:K16885	-	-	-	-	ko00000	-	-	-	FAD_oxidored,NAD_binding_8,Pyr_redox_2
k59_495801_1	1288494.EBAPG3_29900	4.45e-27	101.0	COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,2VR2N@28216|Betaproteobacteria,37358@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
k59_495801_2	686340.Metal_3304	1.01e-28	105.0	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,1XFGP@135618|Methylococcales	135618|Methylococcales	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
k59_730880_1	1267005.KB911257_gene952	6.19e-31	124.0	COG1329@1|root,COG1329@2|Bacteria,1MWI2@1224|Proteobacteria,2TTVP@28211|Alphaproteobacteria,3N6QG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	CarD-like/TRCF domain	carD	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
k59_848247_1	879212.DespoDRAFT_00281	3.5e-44	161.0	COG4826@1|root,COG5549@1|root,COG4826@2|Bacteria,COG5549@2|Bacteria,1REGX@1224|Proteobacteria,42T9N@68525|delta/epsilon subdivisions,2WPDB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
k59_1375982_1	522306.CAP2UW1_1016	2.99e-69	221.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria	1224|Proteobacteria	S	Hemolysins and related proteins containing CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1138755_1	367299.JOEE01000012_gene3269	1.3e-07	52.4	COG0583@1|root,COG0583@2|Bacteria,2GTX3@201174|Actinobacteria,4FGH9@85021|Intrasporangiaceae	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K09681	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_1138755_2	367299.JOEE01000012_gene3270	4.12e-59	189.0	COG1192@1|root,COG1192@2|Bacteria,2GNEQ@201174|Actinobacteria,4FEP8@85021|Intrasporangiaceae	201174|Actinobacteria	D	Plasmid partitioning protein ParA	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_274666_1	656024.FsymDg_0568	3.92e-44	162.0	COG2865@1|root,COG2865@2|Bacteria,2I3IG@201174|Actinobacteria,4EXAT@85013|Frankiales	201174|Actinobacteria	K	Putative ATP-dependent DNA helicase recG C-terminal	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
k59_730883_1	1125863.JAFN01000001_gene1020	1.98e-22	98.2	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,42P15@68525|delta/epsilon subdivisions,2WK8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_7,rve
k59_1436127_1	765910.MARPU_11175	4.14e-83	258.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria,1WXS3@135613|Chromatiales	135613|Chromatiales	S	Flavocytochrome c sulphide dehydrogenase, flavin-binding	-	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.8.2.3	ko:K17229	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2,TAT_signal
k59_1785986_1	765912.Thimo_2101	4.36e-39	148.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1WXN2@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)	-	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
k59_1785986_2	160488.PP_4682	2.26e-18	87.0	COG3071@1|root,COG3071@2|Bacteria,1N8NX@1224|Proteobacteria,1SC7X@1236|Gammaproteobacteria,1YVDQ@136845|Pseudomonas putida group	1236|Gammaproteobacteria	H	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
k59_1785986_3	519989.ECTPHS_03577	2.72e-155	461.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1WWG0@135613|Chromatiales	135613|Chromatiales	L	Helicase	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
k59_979320_1	1366046.HIMB11_00324	1.76e-27	108.0	COG5285@1|root,COG5285@2|Bacteria,1R7DG@1224|Proteobacteria,2TTB2@28211|Alphaproteobacteria,3ZHFQ@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	C	Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
k59_979320_2	1452718.JBOY01000040_gene1935	4.2e-22	91.3	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses	nadE	-	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_979326_1	656024.FsymDg_3579	3.55e-49	178.0	COG2203@1|root,COG3829@1|root,COG5001@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4ESAW@85013|Frankiales	201174|Actinobacteria	T	PAS fold domain protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
k59_320039_1	471853.Bcav_2989	2.45e-54	182.0	COG0112@1|root,COG0112@2|Bacteria,2GK7U@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006563,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009069,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019752,GO:0019842,GO:0020012,GO:0030170,GO:0030312,GO:0030682,GO:0036094,GO:0042133,GO:0042783,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044464,GO:0046983,GO:0048037,GO:0050662,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0071944,GO:0075136,GO:0097159,GO:1901363,GO:1901564,GO:1901605	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_320039_2	1304865.JAGF01000001_gene2067	1.15e-165	468.0	COG0190@1|root,COG0190@2|Bacteria,2GJZS@201174|Actinobacteria,4F22H@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0040007,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
k59_1728506_2	367299.JOEE01000004_gene1354	1.33e-46	159.0	COG0275@1|root,COG0275@2|Bacteria,2GJGK@201174|Actinobacteria,4FETT@85021|Intrasporangiaceae	201174|Actinobacteria	M	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_1500154_1	566466.NOR53_2298	3.92e-51	168.0	COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,1S3XB@1236|Gammaproteobacteria,1J8XZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Nudix N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N_2
k59_98436_1	1200352.A606_11105	1.01e-55	190.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,22KQ3@1653|Corynebacteriaceae	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.44	ko:K00666,ko:K20034	ko00920,map00920	-	R10820	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_1265729_1	1307759.JOMJ01000003_gene954	6.34e-92	298.0	COG3515@1|root,COG5283@1|root,COG5412@1|root,COG3515@2|Bacteria,COG5283@2|Bacteria,COG5412@2|Bacteria,1P1DE@1224|Proteobacteria,42PIK@68525|delta/epsilon subdivisions,2WKHC@28221|Deltaproteobacteria,2M9DQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	TIGRFAM Phage tail tape measure protein TP901	-	-	-	-	-	-	-	-	-	-	-	-	PhageMin_Tail
k59_1020208_1	1265313.HRUBRA_00927	6.37e-96	289.0	COG0811@1|root,COG0811@2|Bacteria,1NXZ9@1224|Proteobacteria,1S154@1236|Gammaproteobacteria,1J4YC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	COG0811 Biopolymer transport proteins	-	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
k59_672362_1	631362.Thi970DRAFT_00599	2.39e-124	370.0	COG4467@1|root,COG4467@2|Bacteria,1PPMF@1224|Proteobacteria,1S1PB@1236|Gammaproteobacteria,1WY6Q@135613|Chromatiales	135613|Chromatiales	S	COG3436 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
k59_1859845_2	216594.MMAR_0921	1.05e-51	189.0	COG0577@1|root,COG0577@2|Bacteria,2I5G9@201174|Actinobacteria,23906@1762|Mycobacteriaceae	201174|Actinobacteria	V	ABC-type transport system, involved in lipoprotein release, permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
k59_1331571_1	522306.CAP2UW1_2245	5.29e-131	398.0	28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,2VMEK@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Pfam Fatty acid	cti	-	-	-	-	-	-	-	-	-	-	-	CTI
k59_144110_2	443906.CMM_1457	3.54e-29	117.0	COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,4FM0X@85023|Microbacteriaceae	201174|Actinobacteria	E	ERAP1-like C-terminal domain	pepN	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
k59_1859852_1	1379281.AVAG01000018_gene1038	2.93e-24	102.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,42QAC@68525|delta/epsilon subdivisions,2WN8H@28221|Deltaproteobacteria,2MB4Q@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_672364_1	765913.ThidrDRAFT_2978	8.08e-102	311.0	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,1RQ50@1236|Gammaproteobacteria,1WWA9@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD dependent oxidoreductase	-	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
k59_554473_1	471853.Bcav_2332	1.58e-53	187.0	COG1403@1|root,COG1403@2|Bacteria,2IMMB@201174|Actinobacteria	201174|Actinobacteria	L	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_98464_1	765911.Thivi_0844	3.3e-66	213.0	COG0547@1|root,COG0547@2|Bacteria,1QDR6@1224|Proteobacteria,1T9UH@1236|Gammaproteobacteria,1WW56@135613|Chromatiales	135613|Chromatiales	E	PFAM Glycosyl transferase, family	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_trans_3N,Glycos_transf_3
k59_202669_1	247633.GP2143_07704	1.2e-98	299.0	COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,1RM9W@1236|Gammaproteobacteria,1J55H@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	COG1157 Flagellar biosynthesis type III secretory pathway ATPase	fliI	-	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1671083_1	1278309.KB907109_gene3302	1.53e-84	261.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1XIU7@135619|Oceanospirillales	135619|Oceanospirillales	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
k59_1138796_1	471853.Bcav_0976	2.52e-37	134.0	COG1947@1|root,COG1947@2|Bacteria,2GKXD@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0040007,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_672375_1	1095767.CAHD01000225_gene1009	3.43e-106	324.0	COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria,4F0UQ@85016|Cellulomonadaceae	201174|Actinobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_1728540_1	864051.BurJ1DRAFT_2902	9.42e-101	300.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VJTU@28216|Betaproteobacteria,1KJWS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
k59_1551974_1	1123517.JOMR01000001_gene1730	2.42e-107	325.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,4606I@72273|Thiotrichales	72273|Thiotrichales	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_1728541_1	1049564.TevJSym_aa01910	1.23e-65	201.0	COG3255@1|root,COG3255@2|Bacteria,1RI49@1224|Proteobacteria,1S38T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1138798_1	1304865.JAGF01000001_gene3876	3.92e-83	256.0	COG0609@1|root,COG0609@2|Bacteria,2GK8Z@201174|Actinobacteria,4F0X3@85016|Cellulomonadaceae	201174|Actinobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
k59_391943_1	880072.Desac_1024	5.19e-46	160.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2WKTU@28221|Deltaproteobacteria,2MQRV@213462|Syntrophobacterales	28221|Deltaproteobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_41559_2	760011.Spico_0472	5.44e-60	199.0	COG0126@1|root,COG0126@2|Bacteria,2J68Y@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_1201103_1	631362.Thi970DRAFT_00979	9.43e-58	195.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1WVW0@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1201103_2	105559.Nwat_0989	1.46e-24	99.8	COG2267@1|root,COG2267@2|Bacteria,1N2R9@1224|Proteobacteria,1T1K8@1236|Gammaproteobacteria,1X2NI@135613|Chromatiales	135613|Chromatiales	I	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters	bioH	-	3.1.1.85	ko:K02170	ko00780,ko01100,map00780,map01100	M00572	R09725	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1671094_1	879212.DespoDRAFT_01289	5.44e-91	288.0	COG0490@1|root,COG1226@1|root,COG4651@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WK23@28221|Deltaproteobacteria,2MHVK@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
k59_848312_2	714083.JH370377_gene1398	2.18e-86	264.0	COG0596@1|root,COG0596@2|Bacteria,2GNBX@201174|Actinobacteria,4FMA9@85023|Microbacteriaceae	201174|Actinobacteria	S	Belongs to the peptidase S33 family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
k59_98495_1	2880.D7FSC9	2.1e-10	67.4	COG1678@1|root,2QV60@2759|Eukaryota	2759|Eukaryota	K	Uncharacterized ACR, COG1678	-	-	-	-	-	-	-	-	-	-	-	-	DUF179
k59_619840_1	247633.GP2143_16336	7.49e-08	53.9	2DP15@1|root,3303T@2|Bacteria,1N7NN@1224|Proteobacteria,1SBQR@1236|Gammaproteobacteria,1JBXR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Domain of unknown function (DUF4426)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4426
k59_619840_2	555778.Hneap_1838	1.27e-19	87.4	COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,1WXC6@135613|Chromatiales	135613|Chromatiales	S	integral membrane protein	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
k59_51532_1	1121439.dsat_0127	7.69e-39	144.0	2C6D0@1|root,31F07@2|Bacteria,1RHBN@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
k59_990680_1	1049564.TevJSym_bc00380	3.06e-116	345.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1JBG6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cysteine-rich domain	dgcB	-	-	ko:K21834	-	-	-	-	ko00000	-	-	-	CCG,DUF3483,Fer4_8
k59_444004_1	1282876.BAOK01000001_gene2772	1.34e-21	98.6	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2TRI9@28211|Alphaproteobacteria,4BRV4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	MMPL family	MA20_16090	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_502624_1	323261.Noc_0136	2.17e-104	309.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,1WW7W@135613|Chromatiales	135613|Chromatiales	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_1735268_1	384765.SIAM614_14063	2.02e-30	112.0	COG1734@1|root,COG1734@2|Bacteria,1N7D8@1224|Proteobacteria,2UHGM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG1734 DnaK suppressor protein	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
k59_931497_1	1249627.D779_1872	6.31e-176	520.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales	135613|Chromatiales	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1677975_1	794903.OPIT5_23505	7.25e-57	199.0	COG1196@1|root,COG1196@2|Bacteria,46TT8@74201|Verrucomicrobia,3K7E6@414999|Opitutae	414999|Opitutae	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_1207820_1	469371.Tbis_1821	2.35e-59	197.0	COG1597@1|root,COG1597@2|Bacteria,2GK3P@201174|Actinobacteria,4E0R5@85010|Pseudonocardiales	201174|Actinobacteria	I	PFAM Diacylglycerol kinase, catalytic	dagK	GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_cat
k59_679528_2	1278073.MYSTI_04027	5.81e-23	100.0	COG2984@1|root,COG4191@1|root,COG2984@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,ABC_sub_bind,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k59_1025933_1	153948.NAL212_0873	2.46e-60	196.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,372D3@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	cbbR	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_109586_1	207559.Dde_0544	1.7e-32	130.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2MH92@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,Hpt,Response_reg
k59_561249_1	316067.Geob_0751	2.43e-48	158.0	COG1832@1|root,COG1832@2|Bacteria,1NJW8@1224|Proteobacteria,42WY1@68525|delta/epsilon subdivisions,2X9YF@28221|Deltaproteobacteria,43V09@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2
k59_209684_1	519989.ECTPHS_00929	4.31e-132	391.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1WWEC@135613|Chromatiales	135613|Chromatiales	S	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
k59_444017_1	338963.Pcar_3093	1.27e-66	221.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_403112_1	309807.SRU_1857	1.77e-25	105.0	COG3222@1|root,COG3222@2|Bacteria,4NM7F@976|Bacteroidetes,1FK4V@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
k59_790965_1	1122614.JHZF01000013_gene2968	7.16e-71	229.0	COG3975@1|root,COG3975@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1,Peptidase_M61
k59_1383115_1	1265313.HRUBRA_01489	6.07e-50	170.0	2DG8R@1|root,2ZUYV@2|Bacteria,1R8VA@1224|Proteobacteria,1T0PJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
k59_109594_1	452637.Oter_3077	3.72e-13	75.1	COG2982@1|root,COG2982@2|Bacteria,46VEJ@74201|Verrucomicrobia,3K8PP@414999|Opitutae	414999|Opitutae	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
k59_1025939_1	96561.Dole_2294	1.41e-58	194.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,42N3G@68525|delta/epsilon subdivisions,2WIS9@28221|Deltaproteobacteria,2MI5A@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1025939_2	56780.SYN_01179	7.67e-05	42.7	COG1433@1|root,COG1433@2|Bacteria,1MZ77@1224|Proteobacteria,42U3G@68525|delta/epsilon subdivisions,2WQ5N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Dinitrogenase iron-molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
k59_502645_1	1094980.Mpsy_1243	6.4e-75	233.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_619871_1	177437.HRM2_20930	3.69e-31	118.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,42MR6@68525|delta/epsilon subdivisions,2WITP@28221|Deltaproteobacteria,2MHTE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	TIGRFAM TRAP transporter solute receptor, TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_502646_1	1500894.JQNN01000001_gene4578	1.07e-70	226.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2VJN7@28216|Betaproteobacteria,47352@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Signal transduction histidine kinase, nitrogen specific	ntrB	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9
k59_209698_1	2340.JV46_27250	1.58e-44	164.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1J4N3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)	mrcB	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008289,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031406,GO:0031975,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042277,GO:0042546,GO:0042597,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071723,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iECIAI39_1322.ECIAI39_0153,iSBO_1134.SBO_0138,iSbBS512_1146.SbBS512_E0140,iYL1228.KPN_00164	PBP1_TM,Transgly,Transpeptidase,UB2H
k59_738155_2	314230.DSM3645_10562	1.82e-07	55.1	COG1011@1|root,COG1011@2|Bacteria,2J031@203682|Planctomycetes	203682|Planctomycetes	S	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
k59_326957_1	1032480.MLP_31930	7.78e-16	75.9	COG1190@1|root,COG2898@1|root,COG1190@2|Bacteria,COG2898@2|Bacteria,2GKE0@201174|Actinobacteria,4DQ4F@85009|Propionibacteriales	201174|Actinobacteria	J	Uncharacterised conserved protein (DUF2156)	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DUF2156,tRNA-synt_2,tRNA-synt_2_TM,tRNA_anti-codon
k59_326957_3	1123320.KB889671_gene3395	6.27e-10	62.8	COG3305@1|root,COG3305@2|Bacteria,2GNU5@201174|Actinobacteria	201174|Actinobacteria	S	Predicted membrane protein (DUF2127)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2127
k59_738157_1	1211817.CCAT010000045_gene2930	8.94e-47	163.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,36F10@31979|Clostridiaceae	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_109612_1	1236542.BALM01000031_gene1882	4.2e-14	77.4	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,2QAS9@267890|Shewanellaceae	1236|Gammaproteobacteria	D	Peptidase M23B	envC	GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_109612_2	1118153.MOY_16277	1.59e-40	148.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1XH27@135619|Oceanospirillales	135619|Oceanospirillales	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
k59_1871161_1	794903.OPIT5_25535	2.22e-22	93.2	2C0ZJ@1|root,33VV4@2|Bacteria,46VGY@74201|Verrucomicrobia,3K7JZ@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_151277_2	1499967.BAYZ01000095_gene4087	2.53e-53	174.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
k59_990737_2	1172188.KB911821_gene1291	3.12e-70	231.0	COG2385@1|root,COG2385@2|Bacteria,2I3WB@201174|Actinobacteria,4FI8C@85021|Intrasporangiaceae	201174|Actinobacteria	D	sporulation resulting in formation of a cellular spore	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
k59_403141_1	290317.Cpha266_1730	7.64e-44	149.0	2BF7S@1|root,3290C@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1353
k59_284301_1	1158165.KB898877_gene1207	4.33e-43	159.0	COG0637@1|root,COG1554@1|root,COG1877@1|root,COG0637@2|Bacteria,COG1554@2|Bacteria,COG1877@2|Bacteria,1MWJE@1224|Proteobacteria,1RPN6@1236|Gammaproteobacteria,1X03I@135613|Chromatiales	135613|Chromatiales	G	Glycosyl hydrolase family 65 central catalytic domain	-	-	3.2.1.28	ko:K01194	ko00500,ko01100,map00500,map01100	-	R00010	RC00049	ko00000,ko00001,ko00537,ko01000	-	GH37	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2,Trehalose_PPase
k59_790981_1	340177.Cag_0616	6.36e-06	56.2	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Big_3_2,CHU_C,Flg_new,LRR_5
k59_209709_1	314278.NB231_06950	4.69e-84	262.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WW5M@135613|Chromatiales	135613|Chromatiales	EH	Anthranilate synthase component I	-	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_855090_1	269797.Mbar_A3247	1.06e-11	70.1	COG0784@1|root,arCOG02349@1|root,arCOG02349@2157|Archaea,arCOG02386@2157|Archaea	2157|Archaea	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	BAT,GAF_2,HATPase_c,HTH_10,HisKA,HisKA_2,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k59_1735305_1	702113.PP1Y_Mpl478	2.32e-58	200.0	COG2801@1|root,COG2801@2|Bacteria,1MXKK@1224|Proteobacteria,2TTM6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	PFAM Integrase	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1736268_1	1121405.dsmv_1458	3.18e-126	375.0	COG4799@1|root,COG4799@2|Bacteria,1Q9BU@1224|Proteobacteria,42P34@68525|delta/epsilon subdivisions,2WK9S@28221|Deltaproteobacteria,2MI0B@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Carboxyl transferase domain	gcdA	-	4.1.1.70	ko:K01615	ko00362,ko00650,ko01120,map00362,map00650,map01120	-	R03028	RC00832	ko00000,ko00001,ko01000,ko02000	3.B.1.1.3	-	-	Carboxyl_trans
k59_327928_1	913325.N799_10225	4.27e-50	176.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1X2Y0@135614|Xanthomonadales	135614|Xanthomonadales	CP	NADH ubiquinone oxidoreductase subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_1384155_1	1249627.D779_2791	1.14e-70	222.0	COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria,1WVWS@135613|Chromatiales	135613|Chromatiales	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	apaH	-	3.6.1.41	ko:K01525	ko00230,map00230	-	R00125	RC00002	ko00000,ko00001,ko01000	-	-	-	Metallophos
k59_503616_1	998674.ATTE01000001_gene1740	3.51e-164	470.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,46068@72273|Thiotrichales	72273|Thiotrichales	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_1384156_1	335543.Sfum_2069	2.92e-54	184.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria,2MQBH@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_52670_1	493475.GARC_2700	6.07e-19	82.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,1S4E6@1236|Gammaproteobacteria,466GC@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
k59_52670_2	754477.Q7C_359	4.71e-179	517.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,45ZTX@72273|Thiotrichales	72273|Thiotrichales	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_791765_1	367299.JOEE01000004_gene1135	1.73e-109	323.0	COG0240@1|root,COG0240@2|Bacteria,2GJSD@201174|Actinobacteria,4FEJQ@85021|Intrasporangiaceae	201174|Actinobacteria	I	Catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_791765_2	1120950.KB892741_gene2699	8.76e-24	99.4	COG0626@1|root,COG0626@2|Bacteria,2GMD8@201174|Actinobacteria,4DPBS@85009|Propionibacteriales	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metB	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_680506_2	1121405.dsmv_2092	2.53e-56	193.0	COG1132@1|root,COG1132@2|Bacteria,1MVJD@1224|Proteobacteria,42PP5@68525|delta/epsilon subdivisions,2WMQR@28221|Deltaproteobacteria,2MNQK@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1	-	-	ABC_membrane,ABC_tran
k59_932910_1	439235.Dalk_4515	4.55e-135	402.0	COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,43CRI@68525|delta/epsilon subdivisions,2X7Z7@28221|Deltaproteobacteria,2MIWI@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_562198_1	1267534.KB906757_gene956	3.92e-57	199.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase,Trans_reg_C,WD40
k59_1443944_1	102129.Lepto7375DRAFT_1974	8.49e-57	214.0	COG2319@1|root,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria,1H7DY@1150|Oscillatoriales	1117|Cyanobacteria	A	Wd40 repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_35,WD40
k59_562200_1	446466.Cfla_2463	1.01e-66	218.0	COG3480@1|root,COG3480@2|Bacteria,2GJDD@201174|Actinobacteria,4F128@85016|Cellulomonadaceae	201174|Actinobacteria	T	Lon protease (S16) C-terminal proteolytic domain	ylbL	-	-	ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	Lon_C,PDZ_2
k59_992136_1	629265.PMA4326_00150	6e-06	47.8	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,1S64Q@1236|Gammaproteobacteria,1Z51D@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	S	Competence protein	gntX	GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	-	-	-	-	-	-	-	-	-	-	Pribosyltran
k59_992136_2	1122604.JONR01000010_gene3999	9.83e-93	295.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1X4NS@135614|Xanthomonadales	135614|Xanthomonadales	M	Lytic murein transglycosylase	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
k59_152278_1	391615.ABSJ01000026_gene110	3.07e-72	231.0	COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,1J6A4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	PT	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,cNMP_binding
k59_562207_1	1049564.TevJSym_au00260	8.95e-152	436.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,1J4N7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051301,GO:0051704,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_327958_2	574966.KB898652_gene1866	1.09e-17	82.0	COG2925@1|root,COG2925@2|Bacteria,1MV0U@1224|Proteobacteria,1RM85@1236|Gammaproteobacteria,1XHYI@135619|Oceanospirillales	135619|Oceanospirillales	L	Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates	sbcB	-	3.1.11.1	ko:K01141	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_X-T_C,RNase_T
k59_562210_1	318167.Sfri_2291	4.21e-178	527.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,2QAEU@267890|Shewanellaceae	1236|Gammaproteobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_1100203_1	313590.MED134_06214	8.03e-24	107.0	COG0574@1|root,COG0574@2|Bacteria,4NH4R@976|Bacteroidetes,1HWKY@117743|Flavobacteriia,37EID@326319|Dokdonia	976|Bacteroidetes	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_52717_1	439235.Dalk_5011	7.59e-54	187.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MI87@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Acetyl-CoA hydrolase transferase	-	-	-	ko:K18122	ko00650,ko01100,ko01200,map00650,map01100,map01200	-	R05336	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1,Acetyltransf_3
k59_856029_2	1996.JOFO01000078_gene4188	4.32e-20	86.7	28W3T@1|root,2ZI4P@2|Bacteria,2I272@201174|Actinobacteria,4EQKP@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1678975_2	3075.A0A087SN14	1.04e-11	67.8	COG0469@1|root,KOG2323@2759|Eukaryota,37I17@33090|Viridiplantae,34J4Q@3041|Chlorophyta	3041|Chlorophyta	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_791802_1	765912.Thimo_2337	6.66e-14	67.4	2EFZ6@1|root,339RC@2|Bacteria,1P76P@1224|Proteobacteria,1SIDJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_791802_2	768671.ThimaDRAFT_4191	2.99e-17	81.3	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,1WWRZ@135613|Chromatiales	135613|Chromatiales	M	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k59_562230_1	266940.Krad_1208	2.71e-50	171.0	COG1162@1|root,COG1162@2|Bacteria,2GJ37@201174|Actinobacteria	201174|Actinobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
k59_1872628_1	1538295.JY96_13835	4.05e-60	201.0	COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1PD5J@1224|Proteobacteria,2W9PK@28216|Betaproteobacteria,1KMZ3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_3
k59_1100228_1	1445613.JALM01000081_gene957	8.86e-15	80.9	COG4977@1|root,COG4977@2|Bacteria,2I3RG@201174|Actinobacteria	201174|Actinobacteria	K	AraC-binding-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding_2,HTH_18
k59_992199_1	1300345.LF41_1096	4.61e-97	291.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,1S22U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_450512_1	1049564.TevJSym_bt00100	6.19e-30	120.0	COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,1S7I9@1236|Gammaproteobacteria,1JBVR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	MacB-like periplasmic core domain	VPA0559	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1150472_1	13689.BV96_04263	6.67e-71	222.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,2K43N@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1742046_1	177437.HRM2_35240	5.43e-65	217.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,2MHV4@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Penicillin-binding Protein dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928	PBP_dimer,Transpeptidase
k59_685950_2	287.DR97_2970	3.44e-87	272.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1YE4T@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
k59_626480_1	1304865.JAGF01000001_gene2439	1.65e-74	237.0	COG0479@1|root,COG0479@2|Bacteria,2I37A@201174|Actinobacteria	201174|Actinobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
k59_1566228_2	1249627.D779_3325	8.94e-81	264.0	COG0466@1|root,COG0466@2|Bacteria,1NTR5@1224|Proteobacteria,1RPID@1236|Gammaproteobacteria,1WWG2@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1798614_1	768671.ThimaDRAFT_4533	2.15e-101	309.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMFM@1236|Gammaproteobacteria,1WXWQ@135613|Chromatiales	135613|Chromatiales	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k59_687055_1	1120971.AUCA01000102_gene3006	1.69e-64	214.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4H9NW@91061|Bacilli,27A1K@186823|Alicyclobacillaceae	91061|Bacilli	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_1390453_1	1095769.CAHF01000012_gene3418	4.65e-95	287.0	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2VHTD@28216|Betaproteobacteria,472Z6@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Probable molybdopterin binding domain	yfaY	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
k59_1685527_1	1502852.FG94_03049	4.1e-73	237.0	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2VI80@28216|Betaproteobacteria,473A1@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	PFAM HAMP domain, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, His Kinase A (phosphoacceptor) domain, Two-component sensor kinase N-terminal	-	-	2.7.13.3	ko:K07649	ko02020,map02020	M00457	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
k59_510484_1	1415779.JOMH01000001_gene1863	2.93e-22	100.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1X3WG@135614|Xanthomonadales	135614|Xanthomonadales	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_1516270_1	768671.ThimaDRAFT_2570	1.29e-61	202.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1WXMZ@135613|Chromatiales	135613|Chromatiales	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_1516270_2	1255043.TVNIR_3732	9.64e-54	181.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1WY33@135613|Chromatiales	135613|Chromatiales	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	-	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
k59_568956_1	279714.FuraDRAFT_2624	1.05e-52	186.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2VJ54@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
k59_568963_1	177437.HRM2_00630	6.77e-83	251.0	COG2181@1|root,COG2181@2|Bacteria,1MXGZ@1224|Proteobacteria,42SPN@68525|delta/epsilon subdivisions,2WP9D@28221|Deltaproteobacteria,2MMTF@213118|Desulfobacterales	28221|Deltaproteobacteria	C	nitrate reductase, gamma subunit	-	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
k59_1215299_1	317655.Sala_1118	1e-141	416.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TTPD@28211|Alphaproteobacteria,2K2F2@204457|Sphingomonadales	204457|Sphingomonadales	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_158862_1	926569.ANT_06320	3.5e-71	231.0	COG0763@1|root,COG0763@2|Bacteria	2|Bacteria	M	lipid-A-disaccharide synthase activity	-	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	Capsule_synth
k59_1282055_1	1249627.D779_0578	2.17e-110	336.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1WX7K@135613|Chromatiales	135613|Chromatiales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1743366_1	1463821.JOGR01000011_gene2230	2.03e-36	132.0	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria	201174|Actinobacteria	E	dehydrogenase	adh	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1743366_2	446469.Sked_20530	2.21e-31	112.0	COG1917@1|root,COG1917@2|Bacteria,2IFSF@201174|Actinobacteria	201174|Actinobacteria	IQ	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_627778_1	1499967.BAYZ01000054_gene4799	9.13e-63	199.0	COG2096@1|root,COG2096@2|Bacteria,2NPP8@2323|unclassified Bacteria	2|Bacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	yvqK	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.2.1.88,1.5.5.2,2.5.1.17	ko:K00798,ko:K13821	ko00250,ko00330,ko00860,ko01100,ko01110,ko01130,map00250,map00330,map00860,map01100,map01110,map01130	M00122	R00245,R00707,R00708,R01253,R01492,R04444,R04445,R05051,R05220,R07268	RC00080,RC00083,RC00216,RC00242,RC00255,RC00533	ko00000,ko00001,ko00002,ko01000,ko03000	-	-	-	Cob_adeno_trans
k59_1282060_1	880072.Desac_0849	2.72e-73	229.0	COG1847@1|root,COG1847@2|Bacteria,1RB1P@1224|Proteobacteria,42QPK@68525|delta/epsilon subdivisions,2WN58@28221|Deltaproteobacteria,2MRTE@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Jag_N	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
k59_1516305_1	367299.JOEE01000011_gene3201	1.99e-93	282.0	COG0624@1|root,COG0624@2|Bacteria,2GK09@201174|Actinobacteria,4FEKF@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1566276_1	631362.Thi970DRAFT_03923	6.71e-41	148.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1WX73@135613|Chromatiales	135613|Chromatiales	M	PFAM Three-deoxy-D-manno-octulosonic-acid transferase	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N,Kdo
k59_1034673_1	593907.Celgi_2726	7e-156	462.0	COG0046@1|root,COG0046@2|Bacteria,2GKG6@201174|Actinobacteria,4F11M@85016|Cellulomonadaceae	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_687106_1	572477.Alvin_2082	8.58e-34	124.0	COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,1T20F@1236|Gammaproteobacteria,1WW2D@135613|Chromatiales	135613|Chromatiales	E	PFAM Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
k59_1450621_1	1384054.N790_14220	2.09e-42	150.0	COG0491@1|root,COG0491@2|Bacteria,1P5NJ@1224|Proteobacteria,1S04Y@1236|Gammaproteobacteria,1XBW9@135614|Xanthomonadales	135614|Xanthomonadales	S	Metallo-beta-lactamase superfamily	-	-	3.5.2.6	ko:K17837	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
k59_862596_1	237368.SCABRO_00503	4.15e-53	187.0	COG0249@1|root,COG0249@2|Bacteria,2IXGV@203682|Planctomycetes	203682|Planctomycetes	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_217128_1	1134474.O59_003589	1.07e-36	139.0	COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,1RPG9@1236|Gammaproteobacteria,1FH2A@10|Cellvibrio	1236|Gammaproteobacteria	T	His Kinase A (phosphoacceptor) domain	qseC	-	2.7.13.3	ko:K07645	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
k59_1151586_1	78245.Xaut_2830	6.11e-24	99.8	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria,3EXW7@335928|Xanthobacteraceae	28211|Alphaproteobacteria	KQ	O-methyltransferase	arsR	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Methyltransf_11,Methyltransf_31
k59_1151586_2	1158146.KB907121_gene913	5.41e-19	87.8	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,1RMP3@1236|Gammaproteobacteria,1WWKK@135613|Chromatiales	135613|Chromatiales	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
k59_451860_1	583345.Mmol_0626	4.71e-11	62.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2VQC3@28216|Betaproteobacteria,2KMRV@206350|Nitrosomonadales	206350|Nitrosomonadales	D	TIGRFAM maf protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_451860_2	2340.JV46_22770	9.25e-91	282.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1J5GF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	COG1530 Ribonucleases G and E	rng	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_1743425_1	396588.Tgr7_1299	3.5e-53	173.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,1RMMG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
k59_1743425_3	713586.KB900536_gene633	8.47e-12	61.2	2ECSY@1|root,336QI@2|Bacteria,1N9AZ@1224|Proteobacteria,1S9XM@1236|Gammaproteobacteria,1WYWD@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_217136_1	948565.AFFP02000017_gene2301	1.53e-80	268.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1Y6YG@135625|Pasteurellales	135625|Pasteurellales	L	helicase HrpA	hrpA	GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_1450664_1	1268072.PSAB_05650	3.58e-38	131.0	COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,4HGXD@91061|Bacilli,26WZE@186822|Paenibacillaceae	91061|Bacilli	G	Ribose 5-phosphate isomerase	lacA	-	5.3.1.26,5.3.1.6	ko:K01808,ko:K01819	ko00030,ko00051,ko00052,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00052,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R03240,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
k59_687148_1	880072.Desac_2050	5.96e-123	371.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MQ8Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
k59_745884_1	748247.AZKH_1595	2.99e-63	201.0	COG1802@1|root,COG1802@2|Bacteria,1R90Y@1224|Proteobacteria,2VKEN@28216|Betaproteobacteria,2KZVA@206389|Rhodocyclales	206389|Rhodocyclales	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_1743449_1	1121439.dsat_1564	4.79e-22	96.3	COG1077@1|root,COG1077@2|Bacteria,1R875@1224|Proteobacteria,42NJK@68525|delta/epsilon subdivisions,2WKDI@28221|Deltaproteobacteria,2M8XB@213115|Desulfovibrionales	28221|Deltaproteobacteria	D	Cell shape determining protein MreB Mrl	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_1516376_1	880073.Calab_2020	1.73e-39	137.0	COG0377@1|root,COG0377@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	ndhK	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_1516376_2	880073.Calab_2019	5e-19	85.5	COG0650@1|root,COG0650@2|Bacteria,2NRV1@2323|unclassified Bacteria	2|Bacteria	C	NADH dehydrogenase	hycD	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_1390553_1	765914.ThisiDRAFT_1044	8.32e-17	77.4	COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,1SAHT@1236|Gammaproteobacteria,1WY27@135613|Chromatiales	135613|Chromatiales	I	PFAM CDP-alcohol phosphatidyltransferase	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_158946_1	880072.Desac_1463	2.78e-83	276.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2MR0B@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_510597_1	1205753.A989_11314	1.28e-61	197.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,1X416@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
k59_1390562_1	991905.SL003B_1513	1.36e-38	144.0	COG3106@1|root,COG3106@2|Bacteria,1MX6E@1224|Proteobacteria,2TR9Y@28211|Alphaproteobacteria,4BRGG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	YcjX-like family, DUF463	MA20_04550	-	-	ko:K06918	-	-	-	-	ko00000	-	-	-	DUF463
k59_1624544_1	1121861.KB899957_gene2465	6.92e-24	105.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,2TTG7@28211|Alphaproteobacteria,2JV2J@204441|Rhodospirillales	204441|Rhodospirillales	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve
k59_158965_1	1120970.AUBZ01000048_gene3881	2.88e-17	86.3	COG3385@1|root,COG3385@2|Bacteria,1R55Y@1224|Proteobacteria,1RRSD@1236|Gammaproteobacteria,466PM@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1107814_1	1149133.ppKF707_3043	3.33e-47	162.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1YIDJ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1107814_2	1001585.MDS_0759	1.4e-29	110.0	COG4665@1|root,COG4665@2|Bacteria,1RDYM@1224|Proteobacteria,1S58A@1236|Gammaproteobacteria,1YGBG@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_569085_1	754476.Q7A_750	9.73e-41	146.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,460MK@72273|Thiotrichales	72273|Thiotrichales	M	Lipid A biosynthesis	lpxL	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_1516418_1	1282876.BAOK01000001_gene2470	3.46e-55	186.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRCI@28211|Alphaproteobacteria,4BPM4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX1	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_687191_1	1410613.JNKF01000012_gene1726	3.83e-37	143.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,MRJP
k59_745919_1	686340.Metal_3585	1.75e-22	100.0	COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1MUQV@1224|Proteobacteria,1RN0Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,LapD_MoxY_N
k59_745919_2	754476.Q7A_1933	1.52e-37	132.0	COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,1S3Y1@1236|Gammaproteobacteria,460IJ@72273|Thiotrichales	72273|Thiotrichales	S	Bacterial transglutaminase-like cysteine proteinase BTLCP	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C93
k59_510622_1	765911.Thivi_3576	1.25e-53	192.0	COG0419@1|root,COG3264@1|root,COG0419@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1WXKG@135613|Chromatiales	135613|Chromatiales	DM	mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM,MscS_porin
k59_569091_1	1035308.AQYY01000001_gene2319	1.04e-92	279.0	COG2307@1|root,COG2307@2|Bacteria,1V4RG@1239|Firmicutes	1239|Firmicutes	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
k59_1743500_1	1123376.AUIU01000001_gene791	1.19e-44	151.0	COG0378@1|root,COG0378@2|Bacteria,3J128@40117|Nitrospirae	40117|Nitrospirae	KO	CobW/HypB/UreG, nucleotide-binding domain	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
k59_862698_1	1313172.YM304_37160	8.67e-81	259.0	COG2812@1|root,COG2812@2|Bacteria,2GJKA@201174|Actinobacteria,4CMQ5@84992|Acidimicrobiia	84992|Acidimicrobiia	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
k59_1390588_1	326427.Cagg_1245	3.65e-124	369.0	COG0065@1|root,COG0065@2|Bacteria,2G68G@200795|Chloroflexi,3753P@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_627916_1	765913.ThidrDRAFT_1709	3.99e-84	253.0	28P01@1|root,2ZBWR@2|Bacteria,1RB5K@1224|Proteobacteria,1S2PB@1236|Gammaproteobacteria,1WXYS@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_451930_1	314278.NB231_00915	7.66e-103	311.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,1WWEG@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_569107_1	944435.AXAJ01000023_gene5165	2.37e-75	243.0	COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,2VJ41@28216|Betaproteobacteria,1K1GC@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the heat shock protein 70 family	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
k59_1215466_1	384765.SIAM614_25507	6.5e-44	160.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2TVZH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Mg2 and Co2 transporter CorB	corB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_510639_1	685727.REQ_30410	1.99e-115	339.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4FX80@85025|Nocardiaceae	201174|Actinobacteria	S	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
k59_1516449_1	768671.ThimaDRAFT_4841	1.17e-92	287.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales	135613|Chromatiales	I	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_1516449_2	572477.Alvin_2727	2.3e-16	72.8	COG2104@1|root,COG2104@2|Bacteria,1N8P3@1224|Proteobacteria,1SCZM@1236|Gammaproteobacteria,1WZ84@135613|Chromatiales	135613|Chromatiales	H	TIGRFAM thiamine biosynthesis protein ThiS	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
k59_1516451_2	1197706.AKKK01000002_gene4105	3.39e-22	103.0	COG1404@1|root,COG4932@1|root,COG1404@2|Bacteria,COG4932@2|Bacteria,2GQDQ@201174|Actinobacteria,1WBJI@1268|Micrococcaceae	201174|Actinobacteria	MO	S-layer domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,SLH
k59_687215_1	493475.GARC_0619	6.4e-129	378.0	COG1215@1|root,COG1215@2|Bacteria,1MWH9@1224|Proteobacteria,1RPTN@1236|Gammaproteobacteria,4647V@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	-
k59_687215_2	1120970.AUBZ01000017_gene3463	2.09e-36	135.0	COG3769@1|root,COG3769@2|Bacteria,1NFV5@1224|Proteobacteria,1RR9R@1236|Gammaproteobacteria,464IU@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Mannosyl-3-phosphoglycerate phosphatase	yedP	-	2.7.1.31,3.1.3.70	ko:K07026,ko:K15918	ko00051,ko00260,ko00561,ko00630,ko01100,ko01110,ko01130,ko01200,map00051,map00260,map00561,map00630,map01100,map01110,map01130,map01200	M00532	R01514,R05790	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Hydrolase_3,S6PP
k59_1151675_1	561175.KB894093_gene3823	2.9e-52	181.0	COG5650@1|root,COG5650@2|Bacteria,2GJYA@201174|Actinobacteria,4EH30@85012|Streptosporangiales	201174|Actinobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
k59_627938_1	177437.HRM2_23610	2.35e-73	236.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2MIZ1@213118|Desulfobacterales	28221|Deltaproteobacteria	G	PFAM Starch synthase catalytic	-	-	2.4.1.21,3.2.1.1	ko:K00703,ko:K01176	ko00500,ko01100,ko01110,ko02026,ko04973,map00500,map01100,map01110,map02026,map04973	M00565	R02108,R02112,R02421,R11262	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GH13,GT5	-	Glyco_trans_1_4,Glyco_transf_5,Glycos_transf_1
k59_1516459_1	765910.MARPU_15105	2.37e-60	193.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,1RM8D@1236|Gammaproteobacteria,1WWMY@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_1516459_2	402881.Plav_2791	1.25e-27	108.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2TS2D@28211|Alphaproteobacteria,1JN9H@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
k59_1107867_1	1249627.D779_4054	1.17e-83	266.0	COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria,1S06C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Alkaline phosphatase	pafA	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
k59_510658_1	1328313.DS2_08565	9.53e-103	305.0	COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,1RS0K@1236|Gammaproteobacteria,4664W@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Outer membrane lipoprotein-sorting protein	VP1287	-	-	-	-	-	-	-	-	-	-	-	LolA_like
k59_159021_1	243159.AFE_2905	2.48e-96	294.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,2NCE4@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_1215495_1	396588.Tgr7_1912	4.19e-89	273.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1WW6R@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_1151684_2	519989.ECTPHS_05435	5.22e-109	328.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,1WX7U@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_510668_1	933262.AXAM01000002_gene525	4.34e-101	326.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,42KZ7@68525|delta/epsilon subdivisions,2WJP6@28221|Deltaproteobacteria,2MIWZ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487	GATase_6,SIS
k59_745978_1	1200557.JHWV01000035_gene2221	6.71e-84	260.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,4H2SJ@909932|Negativicutes	909932|Negativicutes	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_1685758_1	1265505.ATUG01000001_gene2991	1.84e-42	157.0	COG1578@1|root,COG1578@2|Bacteria,1R50K@1224|Proteobacteria,42Q0S@68525|delta/epsilon subdivisions,2WJ5M@28221|Deltaproteobacteria,2MIQ5@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function DUF89	-	-	-	-	-	-	-	-	-	-	-	-	DUF89
k59_569141_2	1005395.CSV86_11150	4.54e-17	82.0	2E7ZW@1|root,332E8@2|Bacteria,1ND2G@1224|Proteobacteria,1SRKI@1236|Gammaproteobacteria,1YVI2@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157
k59_1215498_1	1000565.METUNv1_02311	2.77e-95	304.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,2KV4W@206389|Rhodocyclales	206389|Rhodocyclales	I	AcyL-CoA dehydrogenase	fadE	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N,DUF1974
k59_1215498_2	105559.Nwat_1450	9.89e-11	63.5	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RN3S@1236|Gammaproteobacteria,1X2EF@135613|Chromatiales	135613|Chromatiales	E	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_166779_3	582744.Msip34_0494	3.46e-37	132.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2WHA3@28216|Betaproteobacteria,2KNEB@206350|Nitrosomonadales	206350|Nitrosomonadales	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1223305_1	1049564.TevJSym_bd00260	1.32e-179	511.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1J7KN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cysteine-rich domain	glpC	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944	1.1.5.3	ko:K00113,ko:K11473	ko00564,ko00630,ko01100,ko01110,ko01120,ko01130,map00564,map00630,map01100,map01110,map01120,map01130	-	R00475,R00848	RC00029,RC00042	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
k59_516510_1	1265502.KB905960_gene308	9.31e-49	168.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,2VIZJ@28216|Betaproteobacteria,4AAX7@80864|Comamonadaceae	28216|Betaproteobacteria	S	Peptidoglycan-binding LysM	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_1526060_1	396588.Tgr7_0941	2.66e-166	489.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_516512_1	62928.azo3927	1.71e-28	119.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2VQ05@28216|Betaproteobacteria,2KW7Q@206389|Rhodocyclales	206389|Rhodocyclales	O	COG4235 Cytochrome c biogenesis factor	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16
k59_1805002_1	1304275.C41B8_04671	5.32e-10	65.1	COG1597@1|root,COG1597@2|Bacteria,1RIZ6@1224|Proteobacteria,1S4KN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
k59_871189_2	1279015.KB908454_gene769	0.000104	47.4	COG2084@1|root,COG2084@2|Bacteria,1RA7F@1224|Proteobacteria,1RMMY@1236|Gammaproteobacteria,1Y59N@135624|Aeromonadales	135624|Aeromonadales	I	Belongs to the 3-hydroxyisobutyrate dehydrogenase family	mmsB	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_575637_1	1184609.KILIM_022_00430	2.05e-53	177.0	COG0300@1|root,COG0300@2|Bacteria,2GKJE@201174|Actinobacteria,4F6SI@85018|Dermatophilaceae	201174|Actinobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
k59_1632854_2	105559.Nwat_0672	2.94e-36	136.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1WWWR@135613|Chromatiales	135613|Chromatiales	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_1805006_1	1304275.C41B8_11950	4.66e-22	90.9	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,1S6B5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	IV02_05925	-	-	-	-	-	-	-	-	-	-	-	Smr
k59_1805006_2	1049564.TevJSym_au00560	1.24e-17	84.7	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,1J50G@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
k59_166805_2	471853.Bcav_1596	7.89e-37	132.0	2CQFE@1|root,32SM3@2|Bacteria,2IR42@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3515)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3515
k59_871208_2	2340.JV46_04780	5.13e-59	194.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1J5IY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system, permease component	VP1997	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_753806_1	553385.JEMF01000009_gene1887	1.51e-56	186.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,1XHE4@135619|Oceanospirillales	135619|Oceanospirillales	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
k59_166815_1	1454004.AW11_03650	5.52e-144	419.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2VHBA@28216|Betaproteobacteria	1224|Proteobacteria	S	CBS domain containing protein	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_1632889_1	483219.LILAB_32190	2.52e-44	151.0	COG4974@1|root,COG4974@2|Bacteria,1RC0C@1224|Proteobacteria,42W1W@68525|delta/epsilon subdivisions,2WRTZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase IS66	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
k59_1805035_1	717785.HYPMC_3257	1.59e-48	168.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,3N8ZI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_694422_1	768671.ThimaDRAFT_1574	3.8e-84	262.0	COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,1RPGZ@1236|Gammaproteobacteria,1WWD2@135613|Chromatiales	135613|Chromatiales	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
k59_1632899_1	88036.EFJ09853	8.2e-83	268.0	COG0778@1|root,2QQGY@2759|Eukaryota,37I4G@33090|Viridiplantae,3G83G@35493|Streptophyta	35493|Streptophyta	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_1043849_1	375286.mma_2792	1.73e-106	322.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VH6U@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,IstB_IS21,rve
k59_1805043_1	717785.HYPMC_4764	2.95e-89	286.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria,3N6B5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_342577_2	189753.AXAS01000062_gene8434	1.71e-39	149.0	COG1289@1|root,COG1289@2|Bacteria,1Q5JG@1224|Proteobacteria,2VBX6@28211|Alphaproteobacteria,3K2KA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Aromatic acid exporter family member 1	-	-	-	-	-	-	-	-	-	-	-	-	FUSC
k59_802774_1	87626.PTD2_02306	4.15e-50	177.0	COG2807@1|root,COG2807@2|Bacteria,1NXQ2@1224|Proteobacteria,1RXXM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_575690_1	237368.SCABRO_03842	1.65e-44	162.0	COG1538@1|root,COG1538@2|Bacteria,2IX1X@203682|Planctomycetes	203682|Planctomycetes	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1526128_1	744980.TRICHSKD4_5929	1.71e-35	132.0	COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2TR59@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_575692_1	656024.FsymDg_3853	1.17e-122	360.0	COG0112@1|root,COG0112@2|Bacteria,2GK7U@201174|Actinobacteria,4ERC5@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_1398354_1	519989.ECTPHS_00345	7.93e-138	420.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1WVV2@135613|Chromatiales	135613|Chromatiales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_634768_2	1545915.JROG01000004_gene2472	1.29e-09	58.5	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2TSYI@28211|Alphaproteobacteria,2JZVM@204457|Sphingomonadales	204457|Sphingomonadales	P	phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_1223401_1	1385935.N836_10600	2.56e-76	238.0	COG0668@1|root,COG0668@2|Bacteria,1G06A@1117|Cyanobacteria	1117|Cyanobacteria	M	COG0668 Small-conductance mechanosensitive channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_1398379_1	1458357.BG58_18575	1.26e-30	124.0	COG3523@1|root,COG3523@2|Bacteria,1MV3D@1224|Proteobacteria,2VJ0M@28216|Betaproteobacteria,1K310@119060|Burkholderiaceae	28216|Betaproteobacteria	S	type VI secretion protein	icmF	-	-	ko:K11891	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	IcmF-related,IcmF_C,ImcF-related_N
k59_802803_1	1123258.AQXZ01000013_gene1909	9.17e-35	134.0	COG2207@1|root,COG2207@2|Bacteria,2IARM@201174|Actinobacteria,4FUMM@85025|Nocardiaceae	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_1526169_1	1173020.Cha6605_2508	0.000503	42.0	COG0013@1|root,COG0013@2|Bacteria,1G0NP@1117|Cyanobacteria	1117|Cyanobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_1526169_2	1141662.OOA_18964	1.27e-13	68.6	COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,3Z8XG@586|Providencia	1236|Gammaproteobacteria	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
k59_1158240_1	342610.Patl_3526	9.86e-06	47.0	COG3116@1|root,COG3116@2|Bacteria,1N9MH@1224|Proteobacteria,1SC7P@1236|Gammaproteobacteria,2Q2TU@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsL	GO:0000003,GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0019954,GO:0022402,GO:0022414,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0043093,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944	-	ko:K03586	-	-	-	-	ko00000,ko03036	-	-	-	FtsL
k59_1158240_2	519989.ECTPHS_01844	8.8e-62	207.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1WWDS@135613|Chromatiales	135613|Chromatiales	M	Catalyzes cross-linking of the peptidoglycan cell wall at the division septum	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
k59_1574789_1	1121405.dsmv_0100	5.87e-19	82.0	COG2316@1|root,COG2316@2|Bacteria,1RA50@1224|Proteobacteria,42QZZ@68525|delta/epsilon subdivisions,2WMUN@28221|Deltaproteobacteria,2MJHQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
k59_1574789_2	269797.Mbar_A1892	3.06e-21	87.4	COG0071@1|root,arCOG01838@2157|Archaea,2Y1IR@28890|Euryarchaeota,2NBAW@224756|Methanomicrobia	224756|Methanomicrobia	O	response to heat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_224993_1	640081.Dsui_0967	1.79e-33	119.0	2E80B@1|root,332EM@2|Bacteria,1N7PZ@1224|Proteobacteria,2VVZX@28216|Betaproteobacteria,2KXET@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_516593_1	1177154.Y5S_03409	8.1e-62	214.0	COG3481@1|root,COG3481@2|Bacteria,1MUZY@1224|Proteobacteria,1RQUZ@1236|Gammaproteobacteria,1XMWG@135619|Oceanospirillales	135619|Oceanospirillales	S	Putative helicase	-	-	-	ko:K12070	-	-	-	-	ko00000,ko02044	3.A.7.11.1	-	-	TraI_2
k59_575725_1	396588.Tgr7_3073	1.24e-168	483.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMFM@1236|Gammaproteobacteria,1WXWQ@135613|Chromatiales	135613|Chromatiales	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k59_516598_2	1121033.AUCF01000010_gene4423	8.96e-25	101.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TRX9@28211|Alphaproteobacteria,2JQ1W@204441|Rhodospirillales	204441|Rhodospirillales	E	FAD dependent oxidoreductase	ordL	-	-	ko:K09471	ko00330,ko01100,map00330,map01100	M00136	R07415	RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	DAO
k59_1750534_1	930169.B5T_04446	2.47e-58	197.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,1XI7M@135619|Oceanospirillales	135619|Oceanospirillales	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_871338_1	1120941.AUBL01000012_gene574	4.42e-71	229.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4D3I6@85005|Actinomycetales	201174|Actinobacteria	U	Helicase secretion neighborhood ATPase	cpaF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
k59_753903_1	96561.Dole_2306	2.48e-56	185.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,42P8R@68525|delta/epsilon subdivisions,2WKIR@28221|Deltaproteobacteria,2MIUI@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_4,tRNA_m1G_MT
k59_871347_1	2340.JV46_20400	1.14e-77	247.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1J5MF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NADH ubiquinone oxidoreductase subunit	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_871347_2	870187.Thini_1439	4.43e-24	101.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,45ZMF@72273|Thiotrichales	72273|Thiotrichales	CP	Proton-translocating NADH-quinone oxidoreductase, chain L	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_458423_2	78345.BMERY_0409	0.000229	48.9	2AU2N@1|root,31JNZ@2|Bacteria,2IJNI@201174|Actinobacteria,4D047@85004|Bifidobacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1458806_2	471853.Bcav_3865	1.32e-59	188.0	COG1051@1|root,COG1051@2|Bacteria,2IQEA@201174|Actinobacteria	201174|Actinobacteria	F	Belongs to the NUDIX hydrolase family	mutT2	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
k59_459920_1	187272.Mlg_2670	5.39e-39	139.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1WVWF@135613|Chromatiales	135613|Chromatiales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
k59_459920_2	236097.ADG881_55	1.36e-09	58.9	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,1XJVK@135619|Oceanospirillales	135619|Oceanospirillales	K	Response regulator of the LytR AlgR family	algR	-	-	ko:K02477,ko:K08083	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
k59_1046117_1	1282876.BAOK01000001_gene1876	3.16e-21	93.6	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,4BPV8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	TRAP-type mannitol chloroaromatic compound transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1046117_2	90814.KL370891_gene57	3.31e-26	103.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1S5Y0@1236|Gammaproteobacteria,4611K@72273|Thiotrichales	72273|Thiotrichales	Q	TRAP-type mannitol chloroaromatic compound transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_696050_1	1349767.GJA_1151	8.82e-11	64.7	COG0697@1|root,COG0697@2|Bacteria,1MXCD@1224|Proteobacteria,2VMQB@28216|Betaproteobacteria,4725D@75682|Oxalobacteraceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_696050_2	1449351.RISW2_00290	0.000421	45.1	COG0477@1|root,COG2814@2|Bacteria,1R3WC@1224|Proteobacteria	1224|Proteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1806481_1	240016.ABIZ01000001_gene4307	3.68e-92	291.0	COG0243@1|root,COG0243@2|Bacteria,46YVI@74201|Verrucomicrobia,2ITH3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_755659_1	1267005.KB911257_gene1025	8.5e-92	275.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2TSFJ@28211|Alphaproteobacteria,3N62S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
k59_1046143_2	670307.HYPDE_33053	1.99e-78	243.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,2TS3F@28211|Alphaproteobacteria,3N6H8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the ALAD family	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_1751930_1	521719.ATXQ01000008_gene942	1.88e-125	370.0	COG1362@1|root,COG1362@2|Bacteria,1NT1D@1224|Proteobacteria,1RPHR@1236|Gammaproteobacteria,1YENV@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Aminopeptidase I zinc metalloprotease (M18)	apeB	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008270,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.21	ko:K01267	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	Peptidase_M18
k59_577178_1	439235.Dalk_4147	3.16e-25	100.0	COG0207@1|root,COG0207@2|Bacteria,1Q4ZG@1224|Proteobacteria,42QWZ@68525|delta/epsilon subdivisions,2WMY5@28221|Deltaproteobacteria,2MJKN@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Thymidylate synthase	-	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
k59_168703_1	1123065.ATWL01000008_gene2528	7.45e-87	275.0	COG0366@1|root,COG0366@2|Bacteria,2GJKR@201174|Actinobacteria	201174|Actinobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_636225_1	935839.JAGJ01000007_gene3049	6.78e-140	415.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4F3B5@85017|Promicromonosporaceae	201174|Actinobacteria	I	AMP-binding enzyme	fadD3	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_696092_1	1121468.AUBR01000049_gene1634	1.73e-36	137.0	COG1150@1|root,COG1150@2|Bacteria,1TRAM@1239|Firmicutes,24CFA@186801|Clostridia,42HT9@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	ko:K16887	-	-	-	-	ko00000	-	-	-	Fer4_17
k59_226726_1	565655.ECBG_01173	1.26e-13	75.5	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,4HAKH@91061|Bacilli,4B0JP@81852|Enterococcaceae	91061|Bacilli	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0009986,GO:0030246,GO:0030247,GO:0044464,GO:2001065	6.1.1.24	ko:K09698	ko00970,ko01100,map00970,map01100	M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iSB619.SA_RS02860	tRNA-synt_1c
k59_1460404_2	446466.Cfla_1248	3.95e-70	235.0	COG4907@1|root,COG4907@2|Bacteria,2GNW7@201174|Actinobacteria	201174|Actinobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
k59_1159755_1	665571.STHERM_c16310	4.67e-09	62.0	COG0330@1|root,COG0330@2|Bacteria,2J5A8@203691|Spirochaetes	203691|Spirochaetes	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_1046201_1	335543.Sfum_0366	1.09e-142	414.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2MQA7@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_873433_1	1122599.AUGR01000005_gene1835	2.18e-36	137.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1RN7K@1236|Gammaproteobacteria,1XR9V@135619|Oceanospirillales	135619|Oceanospirillales	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_755713_1	555500.I215_09671	3.63e-21	91.3	COG0050@1|root,COG0050@2|Bacteria,4NEWS@976|Bacteroidetes,1HWMU@117743|Flavobacteriia	976|Bacteroidetes	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_755713_2	568816.Acin_2214	5.96e-17	73.2	COG0267@1|root,COG0267@2|Bacteria,1VEJ4@1239|Firmicutes,4H5N3@909932|Negativicutes	909932|Negativicutes	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
k59_1400246_1	1049564.TevJSym_av00430	4.42e-117	348.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1J4CI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.98.3	ko:K02495	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R06895	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI39_1322.ECIAI39_3134,iZ_1308.Z5403	HemN_C,Radical_SAM
k59_1400246_2	765911.Thivi_0625	3.35e-06	46.2	2E5B5@1|root,33039@2|Bacteria,1NDK8@1224|Proteobacteria,1SFKE@1236|Gammaproteobacteria,1WZDR@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_873437_1	1415780.JPOG01000001_gene1249	1.37e-83	262.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1X3A1@135614|Xanthomonadales	135614|Xanthomonadales	C	E3 component of 2-oxoglutarate dehydrogenase complex	ldp	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_926_1	1267005.KB911261_gene2257	9.98e-66	212.0	COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,2TR0E@28211|Alphaproteobacteria,3N6KT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	phospho-2-dehydro-3-deoxyheptonate aldolase	aroF	GO:0003674,GO:0003824,GO:0003849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009507,GO:0009536,GO:0009611,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0050896,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
k59_1585630_1	765911.Thivi_0936	0.000615	42.0	COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1WWZ8@135613|Chromatiales	135613|Chromatiales	S	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_1585630_2	870187.Thini_4089	8.54e-60	189.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,1S61C@1236|Gammaproteobacteria,4611H@72273|Thiotrichales	72273|Thiotrichales	I	Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
k59_528974_1	935839.JAGJ01000010_gene354	7.5e-81	247.0	COG1611@1|root,COG1611@2|Bacteria,2GKJH@201174|Actinobacteria,4F3QZ@85017|Promicromonosporaceae	201174|Actinobacteria	S	Possible lysine decarboxylase	fmt2	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_1057471_1	290340.AAur_3616	1.76e-45	153.0	COG4385@1|root,COG4385@2|Bacteria,2IJ99@201174|Actinobacteria	201174|Actinobacteria	S	Phage tail protein (Tail_P2_I)	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
k59_1057471_2	1001240.GY21_14090	1.24e-17	82.0	COG3299@1|root,COG3299@2|Bacteria,2GM5C@201174|Actinobacteria,4FS90@85023|Microbacteriaceae	201174|Actinobacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J,LysM
k59_353470_1	118168.MC7420_5670	8.3e-137	400.0	COG3875@1|root,COG3875@2|Bacteria,1G82E@1117|Cyanobacteria,1HDBH@1150|Oscillatoriales	1117|Cyanobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
k59_1292739_2	631362.Thi970DRAFT_00119	3.41e-28	105.0	2C4KB@1|root,32YM4@2|Bacteria,1N74A@1224|Proteobacteria,1SH6J@1236|Gammaproteobacteria,1X1WN@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_294168_1	1206744.BAGL01000002_gene4132	4.04e-30	120.0	COG4427@1|root,COG4427@2|Bacteria,2HVQW@201174|Actinobacteria,4FVX7@85025|Nocardiaceae	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2332
k59_1526900_1	203122.Sde_2287	1.49e-30	123.0	COG2199@1|root,COG3706@2|Bacteria,1QVPW@1224|Proteobacteria,1T2GC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_1057472_1	1120949.KB903339_gene8070	9.78e-37	138.0	COG2267@1|root,COG3710@1|root,COG2267@2|Bacteria,COG3710@2|Bacteria,2I75H@201174|Actinobacteria	201174|Actinobacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_528979_1	1043493.BBLU01000014_gene1312	1.32e-116	344.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_59978_1	1242864.D187_009139	2.42e-87	286.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2WJTT@28221|Deltaproteobacteria,2YU14@29|Myxococcales	28221|Deltaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
k59_881880_1	172088.AUGA01000016_gene2484	6.37e-97	305.0	COG1409@1|root,COG1409@2|Bacteria,1RHP4@1224|Proteobacteria,2U9B6@28211|Alphaproteobacteria,3K0V6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_940591_1	1123368.AUIS01000003_gene1556	1.45e-33	124.0	COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,1RSEU@1236|Gammaproteobacteria,2NDCA@225057|Acidithiobacillales	225057|Acidithiobacillales	G	Belongs to the phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_763869_1	321955.AAGP01000067_gene1398	3.24e-144	425.0	COG4974@1|root,COG4974@2|Bacteria,2IBD6@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
k59_528990_1	317025.Tcr_0021	2.02e-08	58.2	COG2199@1|root,COG3706@2|Bacteria,1R6GI@1224|Proteobacteria,1T2M9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_528990_2	1225184.ALXE01000036_gene81	5.21e-80	244.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1RQ4B@1236|Gammaproteobacteria,3VXYP@53335|Pantoea	1236|Gammaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
k59_528990_3	322710.Avin_38860	3.82e-26	107.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008194,GO:0008289,GO:0008610,GO:0008654,GO:0008915,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0019897,GO:0019898,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	iE2348C_1286.E2348C_0187,iEcolC_1368.EcolC_3478	LpxB
k59_60006_1	1168065.DOK_10271	5.9e-70	221.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,1RNH3@1236|Gammaproteobacteria,1J5AJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	COG0331 (acyl-carrier-protein) S-malonyltransferase	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iEcE24377_1341.EcE24377A_1213,iJN746.PP_1913,iPC815.YPO1598	Acyl_transf_1
k59_60006_2	323261.Noc_1667	4.3e-21	90.1	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1WWWT@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_646502_1	203122.Sde_3262	7e-29	117.0	COG3250@1|root,COG3934@1|root,COG3250@2|Bacteria,COG3934@2|Bacteria,1R8R6@1224|Proteobacteria,1RZM7@1236|Gammaproteobacteria,4660T@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Glycosyl hydrolases family 2, TIM barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C
k59_1527749_1	1121405.dsmv_2103	4.88e-44	162.0	COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,42NGA@68525|delta/epsilon subdivisions,2WJK3@28221|Deltaproteobacteria,2MJ23@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	TIGRFAM Polyketide-type polyunsaturated fatty acid synthase, PfaA	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,FabA,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
k59_1822373_1	1163617.SCD_n02702	1.03e-77	240.0	28I2K@1|root,2ZAEK@2|Bacteria,1R9HK@1224|Proteobacteria,2VZM5@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1175696_1	1049564.TevJSym_ab01210	6.07e-91	291.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1J5MR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Pyruvate phosphate dikinase	ppdK	-	2.7.3.9,2.7.9.1,2.7.9.2	ko:K01006,ko:K01007,ko:K08483	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00710,map00720,map01100,map01120,map01200,map02060	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko02000	8.A.7	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_529941_1	1386089.N865_04985	7.74e-208	592.0	COG3158@1|root,COG3158@2|Bacteria,2GMPQ@201174|Actinobacteria,4FIXR@85021|Intrasporangiaceae	201174|Actinobacteria	P	K+ potassium transporter	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_1175697_2	1384054.N790_07705	3.74e-31	115.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1X41Z@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the UPF0301 (AlgH) family	algH	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_764668_1	1304865.JAGF01000001_gene3178	1.86e-82	259.0	COG0452@1|root,COG0452@2|Bacteria,2GJGJ@201174|Actinobacteria,4F0SE@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k59_412461_1	864702.OsccyDRAFT_4428	2.99e-67	220.0	COG2939@1|root,COG2939@2|Bacteria,1G45M@1117|Cyanobacteria,1HAFV@1150|Oscillatoriales	1117|Cyanobacteria	E	Serine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
k59_471200_1	1267005.KB911262_gene3341	4.34e-108	337.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria,3N6B5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_823404_1	1232410.KI421415_gene3114	4.03e-54	176.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,42QPX@68525|delta/epsilon subdivisions,2WNF9@28221|Deltaproteobacteria,43SHA@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Crossover junction endodeoxyribonuclease RuvC	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
k59_1645483_1	1499689.CCNN01000007_gene1945	1.01e-23	96.3	COG0693@1|root,COG0693@2|Bacteria,1V5HS@1239|Firmicutes,24KRV@186801|Clostridia	186801|Clostridia	S	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
k59_1469209_1	339671.Asuc_0502	3.72e-16	78.6	COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,1RN28@1236|Gammaproteobacteria,1Y7C1@135625|Pasteurellales	135625|Pasteurellales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs	dusA	-	-	ko:K05539	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_823406_1	543632.JOJL01000012_gene6681	1.16e-54	179.0	COG1175@1|root,COG1175@2|Bacteria,2GMTW@201174|Actinobacteria,4DAPX@85008|Micromonosporales	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_823406_2	1380354.JIAN01000005_gene2640	8.21e-26	105.0	COG0395@1|root,COG0395@2|Bacteria,2GJPZ@201174|Actinobacteria,4F249@85016|Cellulomonadaceae	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_647379_1	765913.ThidrDRAFT_3585	1.43e-140	402.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,1WX7Z@135613|Chromatiales	135613|Chromatiales	HJ	Belongs to the RimK family	rimK	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
k59_412477_1	765913.ThidrDRAFT_3516	4.24e-65	209.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,1RR44@1236|Gammaproteobacteria,1WVVH@135613|Chromatiales	135613|Chromatiales	S	Methyltransferase	-	-	2.1.1.44	ko:K18911	ko00340,map00340	-	R01169	RC00003,RC02308	ko00000,ko00001,ko01000	-	-	-	Methyltransf_33
k59_295099_1	880072.Desac_0524	2.21e-84	259.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,42NGR@68525|delta/epsilon subdivisions,2WIMA@28221|Deltaproteobacteria,2MQE8@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6,5.4.99.58	ko:K01012,ko:K16180	ko00300,ko00780,ko01100,ko01120,map00300,map00780,map01100,map01120	M00123,M00573,M00577	R01078,R10010	RC00441,RC02995	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1582	BATS,Radical_SAM
k59_412478_1	1163389.OOM_0643	2.48e-33	126.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,45ZN0@72273|Thiotrichales	72273|Thiotrichales	D	Tyrosine recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_647388_1	1283299.AUKG01000001_gene2735	1.39e-16	78.6	COG0132@1|root,COG0132@2|Bacteria,2GIZ2@201174|Actinobacteria,4CRYX@84995|Rubrobacteria	84995|Rubrobacteria	H	AAA domain	-	-	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
k59_2162_1	228410.NE1856	2.51e-12	70.5	COG0699@1|root,COG0699@2|Bacteria,1MV59@1224|Proteobacteria,2WB2P@28216|Betaproteobacteria,3724Z@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_1294110_1	1423815.BACR01000006_gene182	3.48e-17	82.8	COG1806@1|root,COG1806@2|Bacteria,1TPG0@1239|Firmicutes,4HB0Q@91061|Bacilli,3F3WK@33958|Lactobacillaceae	91061|Bacilli	F	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation	yqfL	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
k59_941949_1	317025.Tcr_0595	8.02e-78	250.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,460E6@72273|Thiotrichales	72273|Thiotrichales	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_354804_1	2340.JV46_26700	1.87e-46	161.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1JBG6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cysteine-rich domain	dgcB	-	-	ko:K21834	-	-	-	-	ko00000	-	-	-	CCG,DUF3483,Fer4_8
k59_354804_2	1122211.JMLW01000033_gene735	1.43e-12	66.6	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,1S3ST@1236|Gammaproteobacteria,1XJTA@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC,ThiS
k59_883238_2	1123392.AQWL01000002_gene1981	7.01e-48	161.0	COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2VRBQ@28216|Betaproteobacteria,1KSU5@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Ferric reductase like transmembrane component	-	-	-	-	-	-	-	-	-	-	-	-	Ferric_reduct
k59_647390_1	523791.Kkor_0209	4.21e-59	201.0	COG0471@1|root,COG0490@1|root,COG0569@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,COG0569@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1XHSW@135619|Oceanospirillales	135619|Oceanospirillales	P	COG0471 Di- and tricarboxylate transporters	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_1058515_1	572477.Alvin_0167	4.16e-80	258.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1WVWQ@135613|Chromatiales	135613|Chromatiales	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C
k59_941955_1	1163617.SCD_n01729	1.59e-76	235.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2VHWI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
k59_1762654_2	713586.KB900536_gene2594	6.05e-19	80.1	2DQA2@1|root,335JK@2|Bacteria,1NB7S@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1762654_3	187272.Mlg_2539	4.45e-07	48.9	COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,1SCBI@1236|Gammaproteobacteria,1WZ69@135613|Chromatiales	135613|Chromatiales	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	-	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
k59_236701_2	686340.Metal_0372	1.6e-54	191.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XEFJ@135618|Methylococcales	135618|Methylococcales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_354823_1	562973.HMPREF0059_00088	3.03e-23	104.0	COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria,4D3D3@85005|Actinomycetales	201174|Actinobacteria	L	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD_C_2,Viral_helicase1
k59_1234449_1	59538.XP_005976537.1	3.53e-28	115.0	COG0621@1|root,KOG2492@2759|Eukaryota,3AA8B@33154|Opisthokonta,3BVCM@33208|Metazoa,3DB6Y@33213|Bilateria	33208|Metazoa	J	Uncharacterized protein family UPF0054	-	-	-	-	-	-	-	-	-	-	-	-	PhoH,UPF0054
k59_177732_1	686340.Metal_3271	2.13e-82	251.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,1RNUF@1236|Gammaproteobacteria,1XDTC@135618|Methylococcales	135618|Methylococcales	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_764704_1	553385.JEMF01000038_gene593	4.72e-46	166.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1XIGC@135619|Oceanospirillales	135619|Oceanospirillales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_295136_1	697282.Mettu_2059	7.61e-18	85.1	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1XDSX@135618|Methylococcales	135618|Methylococcales	C	NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1410499_2	1123277.KB893172_gene873	5.76e-07	52.4	COG0300@1|root,COG0300@2|Bacteria,4NIWD@976|Bacteroidetes,47MPE@768503|Cytophagia	976|Bacteroidetes	S	KR domain	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
k59_706128_1	525897.Dbac_1965	3.63e-06	49.7	COG2716@1|root,COG2716@2|Bacteria,1N37A@1224|Proteobacteria,42UUR@68525|delta/epsilon subdivisions,2WR1Z@28221|Deltaproteobacteria,2M9MB@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM amino acid-binding ACT domain protein	-	-	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT_6
k59_1704043_1	990285.RGCCGE502_09030	3.99e-29	115.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria,4B80C@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	lpdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1058542_1	1206737.BAGF01000151_gene6270	1.88e-73	236.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria,4FYN0@85025|Nocardiaceae	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
k59_1822462_1	247634.GPB2148_1066	2.18e-106	329.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1J4T4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iECOK1_1307.ECOK1_0652,iECS88_1305.ECS88_0684,iNRG857_1313.NRG857_02925,iPC815.YPO2610	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_177749_1	452637.Oter_1630	3.57e-58	202.0	COG1331@1|root,COG1331@2|Bacteria,46SEJ@74201|Verrucomicrobia,3K76Y@414999|Opitutae	414999|Opitutae	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_177749_2	1038858.AXBA01000001_gene3256	2.58e-11	65.1	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2TS88@28211|Alphaproteobacteria,3EYX0@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	TatD related DNase	MA20_29410	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
k59_412517_2	1033802.SSPSH_003117	3.17e-33	119.0	COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,1S3PA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
k59_1058549_1	497964.CfE428DRAFT_3010	4.33e-77	257.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,46TRH@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Tricorn protease PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_1294173_1	314262.MED193_12338	1.9e-54	186.0	COG3848@1|root,COG3848@2|Bacteria,1MV5C@1224|Proteobacteria,2U2Y8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
k59_1294173_2	452662.SJA_C1-02290	3.29e-09	56.6	COG4638@1|root,COG4638@2|Bacteria,1MX47@1224|Proteobacteria,2TV03@28211|Alphaproteobacteria,2K0WS@204457|Sphingomonadales	204457|Sphingomonadales	P	Rieske (2Fe-2S) domain-containing protein	ligX	-	-	ko:K15060	ko00627,ko01120,map00627,map01120	-	R09275	RC00392,RC01533	ko00000,ko00001	-	-	-	Rieske
k59_1586488_1	717785.HYPMC_4200	8.49e-49	165.0	COG1647@1|root,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,2U5K8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Hydrolase_4
k59_823446_1	765911.Thivi_1361	4.2e-67	218.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1WXQX@135613|Chromatiales	135613|Chromatiales	L	DNA photolyase	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_236737_1	1713.JOFV01000001_gene1958	7.19e-96	284.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4F0T8@85016|Cellulomonadaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	regX3	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_471274_1	1118235.CAJH01000010_gene611	5.2e-64	218.0	COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1X4R3@135614|Xanthomonadales	135614|Xanthomonadales	E	homoserine dehydrogenase	thrA	-	1.1.1.3,2.7.2.4	ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3
k59_354855_1	367299.JOEE01000004_gene1204	7.67e-179	509.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria,4FFMD@85021|Intrasporangiaceae	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
k59_948330_1	2340.JV46_05320	6.51e-20	88.6	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,1S0H0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	cbaA	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_948330_2	2340.JV46_05330	6.84e-77	232.0	COG1622@1|root,COG1622@2|Bacteria,1NZNI@1224|Proteobacteria,1S6Y2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	cytochrome C oxidase subunit II	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
k59_1649912_1	177439.DP2822	8.68e-28	119.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2MHZN@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
k59_299618_1	765910.MARPU_12605	2.9e-135	411.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales	135613|Chromatiales	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_67624_1	1384056.N787_04820	1.4e-76	256.0	COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,1QU0Y@1224|Proteobacteria,1T1KC@1236|Gammaproteobacteria,1X5T6@135614|Xanthomonadales	135614|Xanthomonadales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_1179977_1	314278.NB231_07482	2e-90	283.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1WW7H@135613|Chromatiales	135613|Chromatiales	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1532007_1	272123.Anacy_3210	3.5e-84	274.0	COG0542@1|root,COG0542@2|Bacteria,1G04Z@1117|Cyanobacteria,1HKJQ@1161|Nostocales	1117|Cyanobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_242659_1	446462.Amir_3009	2.72e-45	162.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4DYT1@85010|Pseudonocardiales	201174|Actinobacteria	G	Maltogenic Amylase, C-terminal domain	malL	-	3.2.1.10	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R01718,R01791,R06199	RC00028,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3459,Malt_amylase_C
k59_1300547_2	1216007.AOPM01000071_gene1513	1.37e-38	137.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,2PZW1@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	P	cytochrome c1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
k59_1649925_1	1297569.MESS2_670009	1.84e-85	253.0	COG1943@1|root,COG1943@2|Bacteria,1RF1K@1224|Proteobacteria,2U886@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_123381_1	335543.Sfum_1225	1.06e-203	603.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2MQUW@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1300554_1	870187.Thini_2823	6.42e-107	319.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,4609F@72273|Thiotrichales	72273|Thiotrichales	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_182106_1	521011.Mpal_0661	3.14e-45	160.0	COG3199@1|root,arCOG01350@2157|Archaea,2XUIQ@28890|Euryarchaeota	28890|Euryarchaeota	S	ATP-NAD AcoX kinase	-	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_182106_2	521098.Aaci_1799	9.77e-66	217.0	COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,4HA7P@91061|Bacilli,2782W@186823|Alicyclobacillaceae	91061|Bacilli	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
k59_1649926_1	439235.Dalk_2776	7.2e-102	306.0	COG0247@1|root,COG1146@1|root,COG0247@2|Bacteria,COG1146@2|Bacteria,1N5Q2@1224|Proteobacteria,42P5D@68525|delta/epsilon subdivisions,2WJ9I@28221|Deltaproteobacteria,2MI9D@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8,Fer4_9
k59_1474288_1	305900.GV64_17755	3.15e-121	360.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1XIX5@135619|Oceanospirillales	135619|Oceanospirillales	L	Belongs to the DNA photolyase family	phrB	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_182109_2	1156935.QWE_12418	1.18e-81	249.0	COG3639@1|root,COG3639@2|Bacteria,1MW4F@1224|Proteobacteria,2TTXJ@28211|Alphaproteobacteria,4B73B@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Phosphonate ABC transporter	phnE	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
k59_948365_1	1206732.BAGD01000053_gene1892	2.15e-06	50.8	COG1295@1|root,COG1295@2|Bacteria,2GM6P@201174|Actinobacteria,4FUBG@85025|Nocardiaceae	201174|Actinobacteria	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
k59_948365_2	1304865.JAGF01000001_gene3869	1.67e-49	176.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria	201174|Actinobacteria	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
k59_827617_1	638303.Thal_0905	3.02e-33	125.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45,3.1.1.76	ko:K01061,ko:K22249	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_299639_1	313589.JNB_09554	2.48e-53	179.0	COG0470@1|root,COG0470@2|Bacteria,2GJ8C@201174|Actinobacteria,4FFBG@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA polymerase III subunit delta	holB	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
k59_67653_2	1211114.ALIP01000021_gene82	1.24e-06	57.0	COG1752@1|root,COG1752@2|Bacteria,1Q82E@1224|Proteobacteria,1RRUE@1236|Gammaproteobacteria,1X52B@135614|Xanthomonadales	135614|Xanthomonadales	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_416712_1	550540.Fbal_1168	1.32e-23	94.0	COG0848@1|root,COG0848@2|Bacteria,1RI4M@1224|Proteobacteria,1S4GX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	biopolymer transport protein	exbD2	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_416712_2	550540.Fbal_1168	1.56e-35	126.0	COG0848@1|root,COG0848@2|Bacteria,1RI4M@1224|Proteobacteria,1S4GX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	biopolymer transport protein	exbD2	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_416712_3	1448139.AI20_02185	7.16e-40	139.0	COG0811@1|root,COG0811@2|Bacteria,1MX60@1224|Proteobacteria,1RRX1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	COG0811 Biopolymer transport proteins	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_1532032_2	765912.Thimo_2869	1.93e-53	172.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1WXDE@135613|Chromatiales	135613|Chromatiales	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_1063223_1	1049564.TevJSym_ak00560	8.31e-55	192.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,1J5MJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Ferrous iron transport protein B	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_242707_1	572546.Arcpr_0287	1.29e-12	66.2	COG0517@1|root,arCOG00606@2157|Archaea,2XXE2@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_242707_2	289376.THEYE_A1361	5.09e-63	201.0	COG1392@1|root,COG1392@2|Bacteria	2|Bacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_1300575_1	931627.MycrhDRAFT_3786	1.48e-11	70.5	COG4974@1|root,COG4974@2|Bacteria,2HZZ8@201174|Actinobacteria,2376T@1762|Mycobacteriaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1300575_2	557599.MKAN_21850	1.87e-30	111.0	COG3655@1|root,COG3655@2|Bacteria,2ISZ0@201174|Actinobacteria,23A8C@1762|Mycobacteriaceae	201174|Actinobacteria	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_26
k59_1300575_3	1304865.JAGF01000001_gene2118	3.8e-180	509.0	COG4974@1|root,COG4974@2|Bacteria,2IC5F@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
k59_593069_1	340177.Cag_1333	6.24e-31	119.0	COG1947@1|root,COG1947@2|Bacteria,1FDN3@1090|Chlorobi	1090|Chlorobi	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_593069_2	335543.Sfum_3650	1.72e-30	112.0	2EAFJ@1|root,334IY@2|Bacteria,1NA2Y@1224|Proteobacteria,42VJ1@68525|delta/epsilon subdivisions,2WRKE@28221|Deltaproteobacteria,2MQME@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1844)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1844
k59_534442_1	314265.R2601_05048	1.16e-18	84.7	COG1910@1|root,COG1910@2|Bacteria,1MVS4@1224|Proteobacteria,2TU96@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG1910, Periplasmic molybdate-binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,PBP_like
k59_534442_2	1410670.JHXF01000001_gene2768	4.32e-09	56.6	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia,3WH5S@541000|Ruminococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1300578_1	395493.BegalDRAFT_3416	4.56e-106	315.0	COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,1RYH6@1236|Gammaproteobacteria,45ZY6@72273|Thiotrichales	72273|Thiotrichales	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
k59_1356086_2	1122933.JNIY01000006_gene1932	3.12e-20	84.7	COG0425@1|root,COG0425@2|Bacteria,2GSF4@201174|Actinobacteria,4F2Z8@85016|Cellulomonadaceae	201174|Actinobacteria	O	Sulfurtransferase TusA	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
k59_1063226_1	1150398.JIBJ01000005_gene3227	6.78e-73	228.0	COG1028@1|root,COG1028@2|Bacteria,2GWHQ@201174|Actinobacteria,1WBND@1268|Micrococcaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1649953_1	1118153.MOY_10890	5.27e-55	183.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1XI7V@135619|Oceanospirillales	135619|Oceanospirillales	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	ppnK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_1649953_2	519989.ECTPHS_06952	4.17e-28	112.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1WW15@135613|Chromatiales	135613|Chromatiales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_948389_1	670307.HYPDE_33633	1.49e-186	525.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2TRPR@28211|Alphaproteobacteria,3N6D6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_8880_1	690850.Desaf_0089	7.56e-47	167.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria,2M9K4@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_1474341_1	2340.JV46_02960	4.14e-68	219.0	COG0398@1|root,COG0607@1|root,COG0398@2|Bacteria,COG0607@2|Bacteria,1MVF3@1224|Proteobacteria,1RSK1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	SNARE associated Golgi protein	ydjX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Rhodanese,SNARE_assoc
k59_1474341_2	1049564.TevJSym_ae00650	7.97e-21	89.4	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,1RQJQ@1236|Gammaproteobacteria,1J5P9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_1708289_1	396588.Tgr7_0224	3.72e-32	129.0	COG3031@1|root,COG3031@2|Bacteria,1RD3I@1224|Proteobacteria,1RQKA@1236|Gammaproteobacteria,1X1I0@135613|Chromatiales	135613|Chromatiales	U	General secretion pathway protein C	-	-	-	ko:K02452	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSC
k59_1003189_1	140626.JHWB01000009_gene1102	5.72e-11	68.9	COG2812@1|root,COG2812@2|Bacteria,1VCQC@1239|Firmicutes,248U4@186801|Clostridia	186801|Clostridia	L	'dna polymerase iii	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
k59_948416_1	926566.Terro_2784	2.78e-13	65.5	COG1366@1|root,COG1366@2|Bacteria,3Y4U6@57723|Acidobacteria,2JJH2@204432|Acidobacteriia	204432|Acidobacteriia	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
k59_948416_2	926566.Terro_0925	4.56e-23	101.0	COG0750@1|root,COG0750@2|Bacteria,3Y2KN@57723|Acidobacteria,2JI1B@204432|Acidobacteriia	204432|Acidobacteriia	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
k59_1300614_1	396588.Tgr7_3019	8.24e-163	466.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1WXP7@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_242765_1	381666.H16_A2854	6.57e-57	190.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,2VH6S@28216|Betaproteobacteria,1K0U6@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_182160_1	1116472.MGMO_12c00020	1.37e-107	326.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,1XDQT@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_123447_1	933262.AXAM01000062_gene945	3.67e-69	228.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42M5C@68525|delta/epsilon subdivisions,2WJ54@28221|Deltaproteobacteria,2MJ3U@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lytic transglycosylase catalytic	mltD2	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_1063259_1	1049564.TevJSym_bb00290	7.36e-55	192.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1T216@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg
k59_651887_1	290398.Csal_0434	3.54e-47	153.0	COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,1S62N@1236|Gammaproteobacteria,1XKDP@135619|Oceanospirillales	135619|Oceanospirillales	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
k59_651887_2	396588.Tgr7_2310	4.61e-59	185.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,1S452@1236|Gammaproteobacteria,1WXYT@135613|Chromatiales	135613|Chromatiales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
k59_651887_3	118797.XP_007457196.1	1.56e-80	247.0	COG0096@1|root,COG0097@1|root,KOG1754@2759|Eukaryota,KOG3254@2759|Eukaryota,39WCS@33154|Opisthokonta	33154|Opisthokonta	J	rRNA binding	MRPL6	GO:0000313,GO:0000315,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005762,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0031974,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0097159,GO:0098798,GO:0140053,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_242792_1	1121937.AUHJ01000019_gene1318	7.62e-109	340.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,464B1@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_242792_2	396588.Tgr7_2294	1.46e-36	135.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1WXE2@135613|Chromatiales	135613|Chromatiales	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_475685_1	373903.Hore_21070	4.16e-135	404.0	COG5012@1|root,COG5012@2|Bacteria,1UHX7@1239|Firmicutes,25E66@186801|Clostridia	186801|Clostridia	S	cobalamin B12-binding domain protein	oraE	-	5.4.3.5	ko:K17898	ko00472,map00472	-	R02461	RC00719	ko00000,ko00001,ko01000	-	-	-	B12-binding,Lys-AminoMut_A,OAM_dimer
k59_1356131_1	481448.Minf_2172	5.29e-55	187.0	COG0617@1|root,COG0617@2|Bacteria,46S8B@74201|Verrucomicrobia,37FVR@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	J	Probable RNA and SrmB- binding site of polymerase A	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
k59_1590554_1	754476.Q7A_441	2.88e-48	176.0	COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria,462AQ@72273|Thiotrichales	72273|Thiotrichales	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07673	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA_3,PilJ
k59_1120577_1	1267005.KB911257_gene1043	5.88e-88	270.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2TRZU@28211|Alphaproteobacteria,3N6KV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	ubiH	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_710486_1	471853.Bcav_2621	4.78e-89	281.0	COG3590@1|root,COG3590@2|Bacteria,2GNJY@201174|Actinobacteria	201174|Actinobacteria	O	peptidase	pepO	-	3.4.24.11,3.4.24.71	ko:K01389,ko:K01415,ko:K07386	ko04614,ko04640,ko04974,ko05010,map04614,map04640,map04974,map05010	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
k59_768288_1	882083.SacmaDRAFT_1647	3.9e-76	244.0	COG3004@1|root,COG3004@2|Bacteria,2GKIK@201174|Actinobacteria,4DXDZ@85010|Pseudonocardiales	201174|Actinobacteria	P	) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_476321_1	1121374.KB891575_gene1526	3.51e-34	133.0	COG0591@1|root,COG0591@2|Bacteria,1R86J@1224|Proteobacteria,1S1QC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_417435_2	768671.ThimaDRAFT_0893	2.56e-117	345.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1WWNM@135613|Chromatiales	135613|Chromatiales	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_890471_1	388413.ALPR1_19473	6.3e-122	360.0	COG0148@1|root,COG0148@2|Bacteria,4NF5M@976|Bacteroidetes,47MI4@768503|Cytophagia	976|Bacteroidetes	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_1121135_1	1042876.PPS_1507	2.25e-61	196.0	COG0500@1|root,COG0500@2|Bacteria,1RAE4@1224|Proteobacteria,1S0RC@1236|Gammaproteobacteria,1YVGJ@136845|Pseudomonas putida group	1236|Gammaproteobacteria	H	Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family	tpm	GO:0003674,GO:0003824,GO:0008119,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008757,GO:0010035,GO:0010038,GO:0016740,GO:0016741,GO:0032259,GO:0042221,GO:0046690,GO:0050896	2.1.1.67	ko:K00569	ko00983,map00983	-	R08236,R08239,R08246	RC00003,RC00980,RC02277	ko00000,ko00001,ko01000	-	-	-	TPMT
k59_828390_1	999611.KI421504_gene495	6.22e-155	437.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,281XJ@191028|Leisingera	28211|Alphaproteobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_828390_2	467661.RKLH11_4101	3.08e-225	624.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,3ZIA6@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	L	L COG4584 Transposase and inactivated derivatives	istA	-	-	-	-	-	-	-	-	-	-	-	rve
k59_10344_1	266265.Bxe_C0490	3.39e-42	152.0	COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2VWYN@28216|Betaproteobacteria,1K8UX@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	Transposase_20
k59_1829774_1	1123368.AUIS01000006_gene603	1.6e-10	64.3	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,2NC51@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	-	-	ko:K10764	ko00270,ko00920,ko01100,map00270,map00920,map01100	-	R01288	RC00020,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1829774_2	443152.MDG893_11386	5.98e-21	90.5	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,465JF@72275|Alteromonadaceae	1236|Gammaproteobacteria	EH	Branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_244135_2	911239.CF149_18336	1.26e-25	104.0	COG0835@1|root,COG0835@2|Bacteria,1RCIR@1224|Proteobacteria,1S61F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NT	chemotaxis signal transduction protein	pilI	-	-	ko:K02659	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	CheW
k59_244135_3	85643.Tmz1t_3689	8.71e-39	133.0	COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,2VSSD@28216|Betaproteobacteria,2KWTI@206389|Rhodocyclales	206389|Rhodocyclales	T	response regulator receiver	pilH	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_949429_1	1123368.AUIS01000019_gene1224	2.12e-107	328.0	COG0569@1|root,COG1226@1|root,COG0569@2|Bacteria,COG1226@2|Bacteria,1R3QQ@1224|Proteobacteria,1RPFS@1236|Gammaproteobacteria,2NC05@225057|Acidithiobacillales	225057|Acidithiobacillales	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
k59_1064340_1	2340.JV46_22540	2.07e-121	374.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1J57N@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1415935_1	1499967.BAYZ01000048_gene2713	5.47e-76	244.0	COG2103@1|root,COG2103@2|Bacteria,2NP6Y@2323|unclassified Bacteria	2|Bacteria	S	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate	murQ	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	SIS,SIS_2
k59_1532764_1	1439940.BAY1663_00359	4.09e-23	106.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_417448_1	446469.Sked_32250	2.36e-118	367.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2GKI9@201174|Actinobacteria	201174|Actinobacteria	C	FAD linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8
k59_1240442_1	1116472.MGMO_53c00430	3.7e-10	65.1	COG4796@1|root,COG4796@2|Bacteria,1RCNA@1224|Proteobacteria,1SE5I@1236|Gammaproteobacteria,1XFB4@135618|Methylococcales	135618|Methylococcales	U	Belongs to the GSP D family	-	-	-	-	-	-	-	-	-	-	-	-	Secretin
k59_1180927_1	1454004.AW11_00566	2.17e-117	340.0	COG1392@1|root,COG1392@2|Bacteria,1MXY9@1224|Proteobacteria	1224|Proteobacteria	P	Phosphate transport regulator (Distant homolog of PhoU)	UF78_21250	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_1306344_1	2340.JV46_17540	3.13e-24	100.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1J70K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Dimerisation domain of Zinc Transporter	fieF	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_1306344_2	1116472.MGMO_122c00200	2.67e-24	93.6	COG0425@1|root,COG0425@2|Bacteria,1QIAC@1224|Proteobacteria,1TG4H@1236|Gammaproteobacteria,1XFM0@135618|Methylococcales	135618|Methylococcales	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
k59_1306344_3	1198232.CYCME_0023	1.94e-200	561.0	COG0301@1|root,COG0301@2|Bacteria,1N1R1@1224|Proteobacteria,1T212@1236|Gammaproteobacteria,45ZU6@72273|Thiotrichales	72273|Thiotrichales	H	Thiamine biosynthesis protein (ThiI)	-	-	-	-	-	-	-	-	-	-	-	-	ThiI
k59_420804_1	933262.AXAM01000009_gene1481	1.17e-75	239.0	28MQN@1|root,2ZAZG@2|Bacteria,1MVVQ@1224|Proteobacteria,42MMM@68525|delta/epsilon subdivisions,2WKA1@28221|Deltaproteobacteria,2MHKP@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1834550_1	460265.Mnod_2684	3.89e-28	114.0	COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2TRRK@28211|Alphaproteobacteria,1JR1Y@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	PFAM Coenzyme A transferase	pct	-	2.8.3.1	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	-	R00928,R01449,R05508	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_479652_1	1121405.dsmv_0942	5.26e-33	121.0	COG5663@1|root,COG5663@2|Bacteria,1MZTH@1224|Proteobacteria,42TWZ@68525|delta/epsilon subdivisions,2WQEQ@28221|Deltaproteobacteria,2MK8P@213118|Desulfobacterales	28221|Deltaproteobacteria	S	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)	-	-	-	ko:K05967	-	-	-	-	ko00000	-	-	-	NT5C
k59_479652_2	439235.Dalk_0401	1.11e-28	107.0	2ECCP@1|root,336AZ@2|Bacteria,1N9PN@1224|Proteobacteria,42W93@68525|delta/epsilon subdivisions,2WRXB@28221|Deltaproteobacteria,2MKUC@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Rho_N
k59_1834560_1	1429851.X548_02020	9.82e-57	187.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1X4AP@135614|Xanthomonadales	135614|Xanthomonadales	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
k59_17047_1	1121405.dsmv_0997	2.11e-47	164.0	COG2848@1|root,COG2848@2|Bacteria,1NAFG@1224|Proteobacteria,42NH7@68525|delta/epsilon subdivisions,2WJJM@28221|Deltaproteobacteria,2MI2J@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Uncharacterised ACR (DUF711)	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
k59_17047_2	555779.Dthio_PD2405	9.11e-37	128.0	COG0693@1|root,COG0693@2|Bacteria,1MY0C@1224|Proteobacteria,42TPX@68525|delta/epsilon subdivisions,2WNCR@28221|Deltaproteobacteria,2MGWH@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM ThiJ PfpI	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
k59_479654_1	1121116.KB894775_gene1096	1.01e-93	289.0	COG0410@1|root,COG3945@1|root,COG0410@2|Bacteria,COG3945@2|Bacteria,1MVVC@1224|Proteobacteria,2VK1I@28216|Betaproteobacteria,4AIYQ@80864|Comamonadaceae	28216|Betaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,Hemerythrin
k59_479654_2	1380387.JADM01000012_gene1546	1.75e-36	132.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,1RQU2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids	livG	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_1480302_1	1123508.JH636444_gene5461	1.65e-83	267.0	COG1166@1|root,COG1166@2|Bacteria,2IX6P@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
k59_1069701_2	380394.Lferr_2797	1.24e-46	163.0	COG5433@1|root,COG5433@2|Bacteria,1RAHU@1224|Proteobacteria,1S1TZ@1236|Gammaproteobacteria,2NDWK@225057|Acidithiobacillales	1236|Gammaproteobacteria	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc,DUF4338
k59_420815_1	290512.Paes_0170	3.72e-18	84.7	COG1403@1|root,COG1403@2|Bacteria,1FDXZ@1090|Chlorobi	1090|Chlorobi	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
k59_1245249_1	857087.Metme_0874	2.35e-41	159.0	COG3291@1|root,COG3291@2|Bacteria,1RGWM@1224|Proteobacteria,1THXR@1236|Gammaproteobacteria,1XFZT@135618|Methylococcales	135618|Methylococcales	S	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD
k59_73458_2	1349820.M707_05645	2.94e-44	147.0	COG2764@1|root,COG2764@2|Bacteria,2IN3F@201174|Actinobacteria	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt,Glyoxalase
k59_1359994_1	555778.Hneap_0004	1.82e-134	405.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1WVZ4@135613|Chromatiales	135613|Chromatiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_1006585_1	765914.ThisiDRAFT_2558	1.89e-18	84.7	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1WVZJ@135613|Chromatiales	135613|Chromatiales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_1006585_2	1158182.KB905027_gene1601	5.71e-32	119.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,1WYG6@135613|Chromatiales	135613|Chromatiales	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
k59_17067_1	1123393.KB891317_gene2287	1.79e-101	300.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2VH2K@28216|Betaproteobacteria,1KRAJ@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_73459_1	398513.BBNG_00526	1.27e-16	85.9	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4CZCX@85004|Bifidobacteriales	201174|Actinobacteria	D	Belongs to the 'phage' integrase family. XerC subfamily	xerC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_17070_1	85643.Tmz1t_2224	5.47e-47	157.0	COG1845@1|root,COG1845@2|Bacteria,1RDNK@1224|Proteobacteria,2VKAY@28216|Betaproteobacteria,2KVB4@206389|Rhodocyclales	206389|Rhodocyclales	C	Heme copper-type cytochrome quinol oxidase, subunit 3	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_1359999_1	1414719.CBYN010000006_gene1242	1.38e-42	152.0	COG1085@1|root,COG1085@2|Bacteria,2IA73@201174|Actinobacteria,22JRN@1653|Corynebacteriaceae	201174|Actinobacteria	C	uridylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4921
k59_1124021_1	269797.Mbar_A1663	1.96e-69	224.0	COG1228@1|root,arCOG00696@2157|Archaea,2XWAY@28890|Euryarchaeota	28890|Euryarchaeota	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1246215_1	365046.Rta_30600	8.31e-98	301.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VIMM@28216|Betaproteobacteria,4AB8V@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit	fdwB	-	1.17.1.9	ko:K00122	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_1835456_1	1713.JOFV01000012_gene815	2.6e-121	361.0	COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4F0SQ@85016|Cellulomonadaceae	201174|Actinobacteria	EG	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_304153_1	1304888.ATWF01000002_gene199	8.18e-26	105.0	COG0791@1|root,COG0791@2|Bacteria,2GFMA@200930|Deferribacteres	200930|Deferribacteres	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,SPOR
k59_1835459_1	926559.JoomaDRAFT_3823	8.61e-19	89.4	COG1063@1|root,COG1063@2|Bacteria,4NHCK@976|Bacteroidetes,1IIK7@117743|Flavobacteriia	976|Bacteroidetes	E	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_421500_1	196162.Noca_0222	5.99e-33	123.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4DTJC@85009|Propionibacteriales	201174|Actinobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	iNJ661.Rv0375c	CO_deh_flav_C,FAD_binding_5
k59_421500_2	1108045.GORHZ_197_00550	1.46e-79	239.0	COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria	201174|Actinobacteria	C	Aerobic-type carbon monoxide dehydrogenase small subunit CoxS	coxS	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	iNJ661.Rv0374c	Fer2,Fer2_2
k59_1007140_1	1122139.KB907869_gene910	1.13e-20	85.9	COG3671@1|root,COG3671@2|Bacteria,1MZMW@1224|Proteobacteria,1S8EV@1236|Gammaproteobacteria,1XKYF@135619|Oceanospirillales	135619|Oceanospirillales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF4870
k59_252003_1	1121405.dsmv_3255	4.82e-94	293.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2MIPH@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_656885_1	1121405.dsmv_2390	1.55e-65	211.0	COG3385@1|root,COG3385@2|Bacteria,1R8CS@1224|Proteobacteria,42P9F@68525|delta/epsilon subdivisions,2WKTA@28221|Deltaproteobacteria,2MJAY@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_2
k59_772198_1	28072.Nos7524_1286	1.31e-15	82.4	COG2931@1|root,COG3210@1|root,COG3291@1|root,COG3595@1|root,COG4070@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG3595@2|Bacteria,COG4070@2|Bacteria,1GHDQ@1117|Cyanobacteria,1HUA0@1161|Nostocales	1117|Cyanobacteria	Q	Domain of unknown function (DUF4114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114
k59_367856_1	335543.Sfum_2152	6.66e-60	207.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2MR16@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase, Fe4S4	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
k59_1536602_1	314278.NB231_10753	5.5e-32	120.0	COG3568@1|root,COG3568@2|Bacteria,1RBWV@1224|Proteobacteria,1S296@1236|Gammaproteobacteria,1X2D7@135613|Chromatiales	135613|Chromatiales	L	Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_1536602_2	754476.Q7A_2839	3.48e-96	296.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,4601B@72273|Thiotrichales	72273|Thiotrichales	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1007144_1	933262.AXAM01000002_gene543	1.32e-87	270.0	COG1916@1|root,COG1916@2|Bacteria,1MWJ0@1224|Proteobacteria,42P2H@68525|delta/epsilon subdivisions,2WJQM@28221|Deltaproteobacteria,2MI76@213118|Desulfobacterales	28221|Deltaproteobacteria	S	TIGRFAM TraB family protein	-	-	-	-	-	-	-	-	-	-	-	-	TraB
k59_1481292_1	367299.JOEE01000005_gene3586	6.91e-69	219.0	COG0176@1|root,COG0176@2|Bacteria,2GMF9@201174|Actinobacteria,4FEYQ@85021|Intrasporangiaceae	201174|Actinobacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
k59_1481292_2	288705.RSal33209_2248	8.41e-11	62.8	COG0166@1|root,COG0166@2|Bacteria,2HT2Q@201174|Actinobacteria,1W8PK@1268|Micrococcaceae	201174|Actinobacteria	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
k59_1360639_2	765910.MARPU_16470	3.99e-44	154.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1WWZW@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_187291_1	666685.R2APBS1_2235	1.86e-05	47.0	COG4969@1|root,COG4969@2|Bacteria,1PJIZ@1224|Proteobacteria,1SEAV@1236|Gammaproteobacteria,1X7RT@135614|Xanthomonadales	135614|Xanthomonadales	NU	Domain of unknown function (DUF4845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4845
k59_187291_2	357804.Ping_0639	7.66e-18	84.3	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,2QHR6@267894|Psychromonadaceae	1236|Gammaproteobacteria	U	Signal peptidase, peptidase S26	lepB	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009987,GO:0010467,GO:0015643,GO:0016020,GO:0016021,GO:0016485,GO:0016787,GO:0017171,GO:0019538,GO:0031224,GO:0031226,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_1246244_1	1217718.ALOU01000019_gene2692	1.35e-33	120.0	COG2010@1|root,COG2010@2|Bacteria,1N73U@1224|Proteobacteria,2VTXS@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	nirC	-	-	ko:K19344	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3
k59_772209_1	1038869.AXAN01000030_gene4023	2.01e-59	192.0	COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2VRBQ@28216|Betaproteobacteria,1K3TE@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain	msrQ	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
k59_1246250_1	1117647.M5M_00180	5.61e-38	139.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1J50Z@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	lpdG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iE2348C_1286.E2348C_4372,iJN746.PP_4187	Pyr_redox_2,Pyr_redox_dim
k59_1246250_2	1125863.JAFN01000001_gene478	4.98e-45	156.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,42N18@68525|delta/epsilon subdivisions,2WJSK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.12,2.3.1.61	ko:K00627,ko:K00658	ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00307	R00209,R02569,R02570,R02571,R08549	RC00004,RC02727,RC02742,RC02833,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2766	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1536616_1	236097.ADG881_1810	1.11e-14	72.8	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,1RPJA@1236|Gammaproteobacteria,1XM9N@135619|Oceanospirillales	135619|Oceanospirillales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2189
k59_1536616_2	748247.AZKH_0625	1.21e-13	68.2	2CNK3@1|root,32SH9@2|Bacteria,1N02U@1224|Proteobacteria,2VUNW@28216|Betaproteobacteria,2KX0T@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of Unknown function (DUF2784)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2784
k59_1307264_1	1298867.AUES01000051_gene4511	3.5e-05	51.6	COG0771@1|root,COG2931@1|root,COG4625@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K2H3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,HemolysinCabind
k59_1481305_1	1123065.ATWL01000002_gene1482	1.84e-39	135.0	COG1051@1|root,COG1051@2|Bacteria,2GJGZ@201174|Actinobacteria	201174|Actinobacteria	F	ADP-ribose pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4916
k59_1481305_2	1304865.JAGF01000001_gene3968	2.29e-88	266.0	COG0127@1|root,COG0127@2|Bacteria,2GM2B@201174|Actinobacteria,4F168@85016|Cellulomonadaceae	201174|Actinobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
k59_18388_1	258533.BN977_05287	2.4e-55	189.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria,236XH@1762|Mycobacteriaceae	201174|Actinobacteria	P	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
k59_1070712_2	1283283.ATXA01000001_gene1277	6.78e-71	223.0	COG2086@1|root,COG2086@2|Bacteria,2GKV6@201174|Actinobacteria,4ES8E@85013|Frankiales	201174|Actinobacteria	C	Electron transfer flavoprotein	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_1246255_1	1042377.AFPJ01000023_gene664	1.17e-61	216.0	COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,46DC5@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
k59_1307266_1	391615.ABSJ01000026_gene112	5.38e-31	126.0	COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1J6GE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE2,Pkinase
k59_252054_1	290315.Clim_0802	3.54e-35	136.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1FD6X@1090|Chlorobi	1090|Chlorobi	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_597526_1	644282.Deba_1841	2.58e-107	311.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,42PQG@68525|delta/epsilon subdivisions,2WMMB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response)	-	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_597526_2	1121439.dsat_0106	7.46e-13	67.0	2CDJ3@1|root,2Z7R6@2|Bacteria,1PZM0@1224|Proteobacteria,42P6U@68525|delta/epsilon subdivisions,2WMMY@28221|Deltaproteobacteria,2MCXK@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_715564_1	207559.Dde_3429	3.04e-50	172.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,42N9K@68525|delta/epsilon subdivisions,2WINH@28221|Deltaproteobacteria,2M8V9@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	PFAM N-6 DNA methylase	hsdM	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
k59_715564_2	338963.Pcar_2926	6.09e-55	171.0	2DPDH@1|root,331MF@2|Bacteria,1PAC4@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_715564_3	207559.Dde_3427	0.0	960.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,42N9K@68525|delta/epsilon subdivisions,2WINH@28221|Deltaproteobacteria,2M8V9@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	PFAM N-6 DNA methylase	hsdM	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
k59_715564_4	880072.Desac_0075	6.58e-76	259.0	COG0286@1|root,COG0732@1|root,COG0286@2|Bacteria,COG0732@2|Bacteria,1MW3A@1224|Proteobacteria,42M3B@68525|delta/epsilon subdivisions,2X2AD@28221|Deltaproteobacteria,2MR4B@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	HsdM N-terminal domain	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
k59_715564_5	207559.Dde_3424	1.21e-08	54.7	COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,42M86@68525|delta/epsilon subdivisions,2WIT1@28221|Deltaproteobacteria,2M8F1@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Subunit R is required for both nuclease and ATPase activities, but not for modification	hsdR	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
k59_1360662_1	1043205.AFYF01000065_gene2178	5.84e-86	264.0	COG0581@1|root,COG0581@2|Bacteria,2I2F2@201174|Actinobacteria,4FFI9@85021|Intrasporangiaceae	201174|Actinobacteria	P	phosphate transport system permease	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_955125_1	313628.LNTAR_16863	1.54e-68	220.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_480353_1	367299.JOEE01000002_gene2460	7.76e-69	223.0	COG0204@1|root,COG0560@1|root,COG0204@2|Bacteria,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,4FF65@85021|Intrasporangiaceae	201174|Actinobacteria	EI	Phospholipid biosynthesis protein	-	-	2.3.1.51,3.1.3.3	ko:K15781	-	-	-	-	ko00000,ko01000	-	-	-	Acyltransferase,HAD
k59_252079_1	688245.CtCNB1_3528	4.08e-43	152.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2VHAX@28216|Betaproteobacteria,4AAE1@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM Rhodanese domain protein	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_252091_1	765910.MARPU_12795	1.92e-62	212.0	COG1629@1|root,COG4771@2|Bacteria,1RKNG@1224|Proteobacteria,1RQYA@1236|Gammaproteobacteria,1WVXK@135613|Chromatiales	135613|Chromatiales	P	TonB-dependent Receptor Plug	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1712765_1	1226994.AMZB01000122_gene2690	1.19e-06	56.2	COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1YEZ2@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Signal transducing histidine kinase, homodimeric domain	chpA	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_832781_2	47839.CCAU010000001_gene3026	6.9e-41	139.0	COG0346@1|root,COG0346@2|Bacteria,2IFUM@201174|Actinobacteria,238NS@1762|Mycobacteriaceae	201174|Actinobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	cadI	GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_480365_1	1121938.AUDY01000008_gene1120	7.26e-12	65.5	2C4JB@1|root,30BI1@2|Bacteria,1VEBD@1239|Firmicutes,4HM1J@91061|Bacilli,3NG6I@45667|Halobacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_74428_1	1341646.CBMO010000059_gene1666	9.74e-104	338.0	COG0515@1|root,COG0515@2|Bacteria,2GMY7@201174|Actinobacteria,23735@1762|Mycobacteriaceae	201174|Actinobacteria	KLT	Nuclease-related domain	-	-	-	-	-	-	-	-	-	-	-	-	NERD,Pkinase
k59_304204_2	713587.THITH_08320	5.25e-33	116.0	2EANF@1|root,334QY@2|Bacteria,1N8X0@1224|Proteobacteria,1SCTI@1236|Gammaproteobacteria,1WYZB@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_304204_3	396588.Tgr7_0609	1.83e-42	145.0	COG5608@1|root,COG5608@2|Bacteria,1N6YX@1224|Proteobacteria,1SE9M@1236|Gammaproteobacteria,1WZ5Z@135613|Chromatiales	135613|Chromatiales	S	SMART Water Stress and Hypersensitive response domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LEA_2
k59_304204_4	1198232.CYCME_0089	3.41e-18	79.0	COG5626@1|root,COG5626@2|Bacteria,1N8QB@1224|Proteobacteria,1SDJI@1236|Gammaproteobacteria,461EU@72273|Thiotrichales	72273|Thiotrichales	S	Protein of unknown function (DUF2288)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2288
k59_1124676_1	338963.Pcar_2923	7.2e-130	395.0	COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,42M86@68525|delta/epsilon subdivisions,2WIT1@28221|Deltaproteobacteria,43TGX@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	Subunit R is required for both nuclease and ATPase activities, but not for modification	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HSDR_N,ResIII
k59_421574_1	1380354.JIAN01000008_gene3423	4.62e-52	170.0	COG0288@1|root,COG0288@2|Bacteria,2GT5H@201174|Actinobacteria,4F0KJ@85016|Cellulomonadaceae	201174|Actinobacteria	P	Reversible hydration of carbon dioxide	cynT	GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008270,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0046872,GO:0046914	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
k59_597562_1	367299.JOEE01000003_gene2883	1.47e-124	370.0	COG1061@1|root,COG1061@2|Bacteria,2GIU5@201174|Actinobacteria,4FEPT@85021|Intrasporangiaceae	201174|Actinobacteria	L	Type III restriction enzyme, res subunit	sdrA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ResIII
k59_1481374_1	994479.GL877878_gene312	1.06e-76	246.0	COG0119@1|root,COG0119@2|Bacteria,2GKYT@201174|Actinobacteria,4E0RH@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA2	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1307334_1	765911.Thivi_3347	3.87e-61	209.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1WXN2@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)	-	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
k59_367954_1	471853.Bcav_3709	1.15e-297	823.0	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria	201174|Actinobacteria	O	Heat shock 70 kDa protein	dnaK	GO:0000302,GO:0000303,GO:0000305,GO:0001968,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016310,GO:0019222,GO:0019538,GO:0019899,GO:0030112,GO:0030162,GO:0030312,GO:0030313,GO:0031323,GO:0031325,GO:0031975,GO:0031982,GO:0032268,GO:0032270,GO:0033554,GO:0034599,GO:0034614,GO:0035375,GO:0036211,GO:0040007,GO:0042221,GO:0042603,GO:0043170,GO:0043226,GO:0043227,GO:0043230,GO:0043388,GO:0043412,GO:0044044,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046677,GO:0046688,GO:0046777,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051098,GO:0051099,GO:0051101,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070613,GO:0070887,GO:0071450,GO:0071451,GO:0071704,GO:0071944,GO:0080090,GO:0097691,GO:1901564,GO:1901700,GO:1901701,GO:1903317,GO:1903319,GO:1903561,GO:2000677,GO:2000679	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_1078053_1	768671.ThimaDRAFT_3374	1.42e-63	202.0	COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,1RRH4@1236|Gammaproteobacteria,1X2HQ@135613|Chromatiales	135613|Chromatiales	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_1078053_2	1121439.dsat_2171	4.22e-65	225.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WMD3@28221|Deltaproteobacteria,2M7W1@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9
k59_191892_1	1123242.JH636435_gene1857	2.33e-68	229.0	COG1199@1|root,COG1199@2|Bacteria,2IX82@203682|Planctomycetes	203682|Planctomycetes	KL	helicase	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
k59_80719_1	472175.EL18_02140	4.81e-14	75.9	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2TR1R@28211|Alphaproteobacteria,43GW2@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_1599612_1	1304865.JAGF01000001_gene3337	4.64e-89	286.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria	201174|Actinobacteria	P	Heavy metal translocating P-type atpase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_1599612_2	1197706.AKKK01000007_gene814	1.85e-35	133.0	COG4447@1|root,COG4447@2|Bacteria,2IGR3@201174|Actinobacteria,1W9E3@1268|Micrococcaceae	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
k59_543571_1	1121374.KB891575_gene1228	2.73e-13	70.5	COG3072@1|root,COG3072@2|Bacteria,1PI5T@1224|Proteobacteria,1RMPZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Adenylate cyclase	cyaA	GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0052652,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.1	ko:K05851	ko00230,ko02026,ko05111,map00230,map02026,map05111	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_2672,iECOK1_1307.ECOK1_4253,iECS88_1305.ECS88_4229,iUMN146_1321.UM146_19155,iUTI89_1310.UTI89_C4365	Adenyl_cycl_N,Adenylate_cycl
k59_543571_2	396588.Tgr7_0591	2.3e-12	63.2	COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria,1S8RW@1236|Gammaproteobacteria,1X2HD@135613|Chromatiales	135613|Chromatiales	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
k59_601912_1	768671.ThimaDRAFT_4426	1.13e-151	442.0	COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria,1SQA0@1236|Gammaproteobacteria,1X16W@135613|Chromatiales	1224|Proteobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_308697_1	272630.MexAM1_META1p1397	1.76e-66	212.0	COG1633@1|root,COG1814@1|root,COG1633@2|Bacteria,COG1814@2|Bacteria,1MUET@1224|Proteobacteria,2TQMZ@28211|Alphaproteobacteria,1JU9D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Rubrerythrin	mbfA	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
k59_837198_1	452638.Pnec_1772	2.61e-22	92.8	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VKD8@28216|Betaproteobacteria,1K3GV@119060|Burkholderiaceae	28216|Betaproteobacteria	T	response regulator	ntrX	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activ_2
k59_543577_1	290512.Paes_0370	1.16e-23	102.0	COG0196@1|root,COG0196@2|Bacteria,1FDJE@1090|Chlorobi	1090|Chlorobi	H	Belongs to the ribF family	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
k59_484809_1	1120954.ATXE01000001_gene1790	5.31e-08	59.3	COG0526@1|root,COG0526@2|Bacteria,2IMCX@201174|Actinobacteria	201174|Actinobacteria	CO	Methylamine utilisation protein MauE	-	-	-	-	-	-	-	-	-	-	-	-	MauE
k59_661545_1	1192759.AKIB01000006_gene30	7.73e-40	150.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,2TUXY@28211|Alphaproteobacteria,2K16Q@204457|Sphingomonadales	204457|Sphingomonadales	EU	peptidase S9	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_133234_1	335543.Sfum_1778	1.49e-64	204.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,42M3Y@68525|delta/epsilon subdivisions,2WJH5@28221|Deltaproteobacteria,2MQCC@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_1313693_1	1218076.BAYB01000027_gene4555	4.44e-39	139.0	COG2404@1|root,COG2404@2|Bacteria,1QWB5@1224|Proteobacteria,2VK0T@28216|Betaproteobacteria,1K3E7@119060|Burkholderiaceae	28216|Betaproteobacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1252286_1	631362.Thi970DRAFT_02211	1.12e-81	264.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1WX60@135613|Chromatiales	135613|Chromatiales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_80751_1	1123518.ARWI01000001_gene683	5.54e-42	149.0	COG2159@1|root,COG2159@2|Bacteria,1R44U@1224|Proteobacteria,1S88Y@1236|Gammaproteobacteria,462IW@72273|Thiotrichales	72273|Thiotrichales	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_80751_2	1045855.DSC_15470	2.09e-06	47.8	2CEDU@1|root,333S9@2|Bacteria,1NI7T@1224|Proteobacteria,1T0VC@1236|Gammaproteobacteria,1X71B@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4156)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4156
k59_426045_1	7213.XP_004532914.1	1.01e-115	366.0	COG0646@1|root,KOG1579@2759|Eukaryota,38H40@33154|Opisthokonta,3BHBF@33208|Metazoa,3CTDE@33213|Bilateria,41UWJ@6656|Arthropoda,3SQNC@50557|Insecta	33208|Metazoa	E	Homocysteine S-methyltransferase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_961521_1	1448139.AI20_18395	4.53e-69	230.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1Y43B@135624|Aeromonadales	135624|Aeromonadales	L	DNA helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1078102_1	1385519.N801_16085	2.25e-35	125.0	COG1196@1|root,COG1196@2|Bacteria,2IMXX@201174|Actinobacteria,4FHC2@85021|Intrasporangiaceae	201174|Actinobacteria	D	Protein of unknown function (DUF4446)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4446
k59_1078102_2	512565.AMIS_80470	9.86e-07	50.8	COG0077@1|root,COG0077@2|Bacteria,2GJQ5@201174|Actinobacteria,4D8DX@85008|Micromonosporales	201174|Actinobacteria	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
k59_374303_1	272560.BPSL2410	1.71e-69	227.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,2VIAZ@28216|Betaproteobacteria,1K108@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor	-	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
k59_258316_1	1249627.D779_0694	7.55e-141	412.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,1RNQI@1236|Gammaproteobacteria,1WW64@135613|Chromatiales	135613|Chromatiales	M	Belongs to the mannose-6-phosphate isomerase type 2 family	-	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_543605_1	865861.AZSU01000001_gene213	1.28e-41	149.0	COG1493@1|root,COG1493@2|Bacteria,1TP5Z@1239|Firmicutes,24999@186801|Clostridia,36F8F@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
k59_1128647_1	497321.C664_14733	2.91e-38	135.0	COG3485@1|root,COG3485@2|Bacteria,1MUYX@1224|Proteobacteria,2VQFX@28216|Betaproteobacteria,2KZ66@206389|Rhodocyclales	206389|Rhodocyclales	Q	Dioxygenase	-	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
k59_1128647_2	314345.SPV1_05003	6.53e-42	147.0	COG3531@1|root,COG3531@2|Bacteria,1RIN9@1224|Proteobacteria	1224|Proteobacteria	O	Protein-disulfide isomerase	VP2116	-	-	ko:K07396	-	-	-	-	ko00000	-	-	-	DSBA,Thioredoxin_5
k59_902578_2	1136417.AZWE01000013_gene2365	1.71e-28	107.0	COG1846@1|root,COG1846@2|Bacteria,2IMGG@201174|Actinobacteria,4DF47@85008|Micromonosporales	201174|Actinobacteria	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
k59_1717296_1	351607.Acel_1602	5.92e-13	72.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4ESA4@85013|Frankiales	201174|Actinobacteria	J	Belongs to the amidase family	amiB	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_1717296_2	1032480.MLP_47490	3.76e-11	65.1	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4DNX8@85009|Propionibacteriales	201174|Actinobacteria	G	Glycosyl hydrolase family 65 central catalytic domain	-	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
k59_601962_1	1469245.JFBG01000023_gene1284	7.46e-56	192.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1WWEF@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_1189989_1	572477.Alvin_1727	2.12e-88	275.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1WWEZ@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1541317_2	713586.KB900536_gene1839	3.26e-85	262.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria,1X0VD@135613|Chromatiales	135613|Chromatiales	F	Belongs to the dGTPase family. Type 2 subfamily	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_258336_1	1123229.AUBC01000031_gene258	1.2e-53	185.0	COG0802@1|root,COG3178@1|root,COG0802@2|Bacteria,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2TSJD@28211|Alphaproteobacteria,3JTQ1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	MA20_24090	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH,TsaE
k59_191947_1	1304865.JAGF01000001_gene2476	5.17e-84	273.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,2GJ0A@201174|Actinobacteria,4F0FS@85016|Cellulomonadaceae	201174|Actinobacteria	E	TIGRFAM glutamate synthase, NADH NADPH, small subunit	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,NAD_binding_1,Pyr_redox_2
k59_543618_2	1528106.JRJE01000020_gene2341	5.96e-27	106.0	COG3247@1|root,COG3247@2|Bacteria,1R63F@1224|Proteobacteria,2U3AR@28211|Alphaproteobacteria,2JUM2@204441|Rhodospirillales	204441|Rhodospirillales	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
k59_1659829_1	883081.HMPREF9698_00820	1.55e-18	90.9	COG0726@1|root,COG0726@2|Bacteria,1V6DN@1239|Firmicutes,4HEPH@91061|Bacilli,27GFQ@186828|Carnobacteriaceae	91061|Bacilli	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	DUF3298,LysM,Polysacc_deac_1
k59_902587_1	472759.Nhal_1189	4.01e-207	610.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_661593_2	1223545.GS4_03_01900	0.000503	42.0	COG0745@1|root,COG3850@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3850@2|Bacteria,COG5002@2|Bacteria,2GJ2D@201174|Actinobacteria,4GB0S@85026|Gordoniaceae	201174|Actinobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	mtrB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	2.7.13.3	ko:K07636,ko:K07654	ko02020,map02020	M00434,M00461	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_961564_1	472759.Nhal_3151	3.23e-53	183.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WXFD@135613|Chromatiales	135613|Chromatiales	P	PFAM Cation	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_1128667_1	927677.ALVU02000001_gene2910	1.79e-10	67.4	COG1215@1|root,COG1215@2|Bacteria,1GPY1@1117|Cyanobacteria,1H6S1@1142|Synechocystis	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_426076_1	225937.HP15_779	1.89e-07	57.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,464ES@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Belongs to the peptidase S1C family	mucD	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_484856_1	1385521.N803_01065	3.08e-59	196.0	COG0438@1|root,COG0438@2|Bacteria,2GNIU@201174|Actinobacteria,4FFTW@85021|Intrasporangiaceae	201174|Actinobacteria	M	galactosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
k59_720192_1	765912.Thimo_0129	1.28e-116	347.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1WX0Q@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
k59_1189998_1	85643.Tmz1t_3220	5.12e-84	269.0	COG0176@1|root,COG0564@1|root,COG0176@2|Bacteria,COG0564@2|Bacteria,1MWQ8@1224|Proteobacteria,2VHIN@28216|Betaproteobacteria,2KV4P@206389|Rhodocyclales	206389|Rhodocyclales	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
k59_1189998_2	317619.ANKN01000126_gene3252	4.63e-75	235.0	COG1028@1|root,COG1028@2|Bacteria,1GC8I@1117|Cyanobacteria,1MM5A@1212|Prochloraceae	1117|Cyanobacteria	IQ	short chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1717315_1	985054.JQEZ01000003_gene1137	4.45e-67	209.0	COG3485@1|root,COG3485@2|Bacteria,1MUYX@1224|Proteobacteria,2TU2C@28211|Alphaproteobacteria,4NB5J@97050|Ruegeria	28211|Alphaproteobacteria	Q	Protocatechuate 3,4-dioxygenase beta subunit	pcaH	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C,PCDO_beta_N
k59_1717315_2	1105367.CG50_00870	2.1e-47	154.0	COG0599@1|root,COG0599@2|Bacteria,1RDSG@1224|Proteobacteria,2U72V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	4-carboxymuconolactone decarboxylase	pcaC	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
k59_1599684_1	543526.Htur_2084	6.03e-11	66.2	COG0531@1|root,COG0589@1|root,arCOG00009@2157|Archaea,arCOG00449@2157|Archaea,2XTX6@28890|Euryarchaeota,23TRU@183963|Halobacteria	183963|Halobacteria	E	COG0531 Amino acid transporters	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2,Usp
k59_1252339_1	331678.Cphamn1_2543	4.72e-235	676.0	COG0610@1|root,COG0610@2|Bacteria	2|Bacteria	L	Subunit R is required for both nuclease and ATPase activities, but not for modification	hsdR	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
k59_1841946_1	1461694.ATO9_12480	3.75e-17	91.7	COG0771@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2V8V8@28211|Alphaproteobacteria,2PFGF@252301|Oceanicola	28211|Alphaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1775784_2	697282.Mettu_2387	1.5e-07	52.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,1RNWU@1236|Gammaproteobacteria,1XF3B@135618|Methylococcales	135618|Methylococcales	C	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_1010916_1	269799.Gmet_2391	1.68e-86	271.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,42PZB@68525|delta/epsilon subdivisions,2WK77@28221|Deltaproteobacteria,43STY@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	PFAM glycoside hydrolase, family 77	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_484863_1	1286093.C266_25790	8.17e-89	269.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VI6B@28216|Betaproteobacteria,1K08B@119060|Burkholderiaceae	28216|Betaproteobacteria	K	response regulator	ompR	-	-	ko:K02483,ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1313768_1	1123326.JFBL01000006_gene1036	2.97e-08	54.3	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2YMES@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1313768_2	1307761.L21SP2_2377	6.48e-30	120.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,2J57W@203691|Spirochaetes	203691|Spirochaetes	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.157,1.1.1.35,4.2.1.17,5.1.2.3	ko:K00074,ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R01976,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R05576,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N
k59_484865_1	991905.SL003B_3656	3.15e-50	174.0	COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,2TSI6@28211|Alphaproteobacteria,4BPDP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the peptidase M17 family	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17
k59_484865_2	1121921.KB898711_gene2034	0.000268	43.9	29T7N@1|root,30EEF@2|Bacteria,1RHQ8@1224|Proteobacteria,1S6XD@1236|Gammaproteobacteria,2PNRD@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1461
k59_1541345_1	1232410.KI421421_gene3631	8.46e-17	79.3	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,42MNS@68525|delta/epsilon subdivisions,2WSQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	MFS_1,TLC
k59_1541345_2	1417296.U879_07455	5.57e-23	90.1	2BZQB@1|root,32Y98@2|Bacteria,1R3P4@1224|Proteobacteria,2UFWD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1541345_3	261292.Nit79A3_1885	7.46e-92	281.0	COG0240@1|root,COG0240@2|Bacteria,1RED0@1224|Proteobacteria,2W2AD@28216|Betaproteobacteria	28216|Betaproteobacteria	I	PFAM NAD-dependent glycerol-3-phosphate dehydrogenase	-	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_1129199_1	565045.NOR51B_608	4.99e-116	350.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1S3FP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1129199_2	2340.JV46_02980	3.36e-19	82.8	COG3439@1|root,COG3439@2|Bacteria,1N4Z5@1224|Proteobacteria,1SG4N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_662187_2	478801.Ksed_08810	1.01e-27	112.0	COG1295@1|root,COG1295@2|Bacteria,2GM6P@201174|Actinobacteria,1ZVTE@145357|Dermacoccaceae	201174|Actinobacteria	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
k59_259188_1	1499967.BAYZ01000088_gene5097	6.7e-18	83.6	COG4591@1|root,COG4591@2|Bacteria,2NP18@2323|unclassified Bacteria	2|Bacteria	M	ABC-type transport system involved in lipoprotein release permease component	lolC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778	-	ko:K02004,ko:K09808	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.125	-	-	FtsX,MacB_PCD
k59_259188_2	1121405.dsmv_3135	6.91e-81	254.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,42M90@68525|delta/epsilon subdivisions,2WJ9G@28221|Deltaproteobacteria,2MHV2@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_375206_1	713586.KB900536_gene3005	4.69e-59	201.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1WXD7@135613|Chromatiales	135613|Chromatiales	M	lytic transglycosylase	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_1011388_1	1121937.AUHJ01000002_gene3617	4.36e-91	288.0	COG1520@1|root,COG1520@2|Bacteria,1QU2U@1224|Proteobacteria,1S1NX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Dehydrogenase	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3
k59_544163_1	562973.HMPREF0059_00288	1.37e-72	241.0	COG0210@1|root,COG0210@2|Bacteria,2GKRW@201174|Actinobacteria,4D37Z@85005|Actinomycetales	201174|Actinobacteria	L	DNA helicase	uvrD2	GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HRDC,UvrD-helicase,UvrD_C
k59_1776396_1	1304865.JAGF01000001_gene670	1.77e-110	337.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4F0IX@85016|Cellulomonadaceae	201174|Actinobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_192557_1	1304865.JAGF01000001_gene2802	8.93e-263	731.0	COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria,4F1NP@85016|Cellulomonadaceae	201174|Actinobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	iNJ661.Rv2992c	tRNA-synt_1c
k59_192557_2	1448389.BAVQ01000083_gene181	2.27e-05	45.8	COG0179@1|root,COG0179@2|Bacteria,2GN2G@201174|Actinobacteria	201174|Actinobacteria	Q	2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase	odx	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
k59_81652_1	1469245.JFBG01000088_gene1667	2.27e-55	185.0	COG0420@1|root,COG0420@2|Bacteria,1MY4X@1224|Proteobacteria,1RSFB@1236|Gammaproteobacteria,1X13V@135613|Chromatiales	135613|Chromatiales	L	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_81652_2	396588.Tgr7_1763	1.6e-10	61.6	COG0419@1|root,COG0419@2|Bacteria,1MXMI@1224|Proteobacteria,1S0N4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15,AAA_23,AAA_27
k59_1541994_1	367299.JOEE01000003_gene2741	5.3e-76	238.0	COG0619@1|root,COG0619@2|Bacteria,2GKHK@201174|Actinobacteria,4FEYI@85021|Intrasporangiaceae	201174|Actinobacteria	P	cobalt ABC transporter, permease	ecfT	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
k59_544166_1	553217.ENHAE0001_1217	8.41e-40	132.0	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,1S8UG@1236|Gammaproteobacteria,3NNZ1@468|Moraxellaceae	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
k59_25394_1	1122139.KB907902_gene10	7.83e-70	226.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1XHZ4@135619|Oceanospirillales	135619|Oceanospirillales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_1314619_1	177439.DP1202	2.73e-76	245.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,2MHX9@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_1780047_1	674977.VMC_37110	4.13e-25	108.0	COG3420@1|root,COG3637@1|root,COG4254@1|root,COG3420@2|Bacteria,COG3637@2|Bacteria,COG4254@2|Bacteria,1QUP0@1224|Proteobacteria,1T3X2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_779572_1	105559.Nwat_3068	2.33e-05	45.8	COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1WYZ6@135613|Chromatiales	135613|Chromatiales	S	Belongs to the Smg family	smg	-	-	ko:K03747	-	-	-	-	ko00000	-	-	-	DUF494
k59_779572_2	1122134.KB893650_gene379	3.96e-31	121.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1XJB4@135619|Oceanospirillales	135619|Oceanospirillales	LU	Rossmann fold nucleotide-binding protein involved in DNA uptake	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_1369573_2	765914.ThisiDRAFT_1543	9.48e-70	217.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,1WX5V@135613|Chromatiales	135613|Chromatiales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
k59_1257697_1	194439.CT0872	6.66e-33	122.0	COG0727@1|root,COG0727@2|Bacteria,1FER9@1090|Chlorobi	1090|Chlorobi	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_967327_1	1035191.HMPREF0185_01498	1.52e-05	52.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2TSI7@28211|Alphaproteobacteria,2KH42@204458|Caulobacterales	204458|Caulobacterales	O	Cytochrome c-type biogenesis protein	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16
k59_264940_1	439235.Dalk_0260	5.22e-43	150.0	COG0789@1|root,COG0789@2|Bacteria,1N7M7@1224|Proteobacteria,42WAT@68525|delta/epsilon subdivisions,2WRPH@28221|Deltaproteobacteria,2MMFX@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM regulatory protein MerR	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
k59_31084_1	631362.Thi970DRAFT_01192	1.31e-78	244.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1WWA7@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_137381_1	105559.Nwat_0059	6.02e-84	282.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RQ0G@1236|Gammaproteobacteria,1WXEX@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_724039_1	366394.Smed_5493	2.46e-39	139.0	COG3381@1|root,COG3381@2|Bacteria,1MWWM@1224|Proteobacteria,2TU06@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	chaperone TorD	torD	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del,YdaS_antitoxin
k59_1319588_1	332101.JIBU02000022_gene5103	7.43e-12	70.9	COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,36FRJ@31979|Clostridiaceae	186801|Clostridia	J	tRNA nucleotidyltransferase poly(A) polymerase	cca	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
k59_841438_1	765911.Thivi_3908	3.55e-29	107.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,1S3PT@1236|Gammaproteobacteria,1WX50@135613|Chromatiales	135613|Chromatiales	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
k59_1847749_1	367299.JOEE01000003_gene2935	2.15e-133	405.0	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4FFSV@85021|Intrasporangiaceae	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_264953_1	1121015.N789_13920	1.69e-63	209.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1X4GI@135614|Xanthomonadales	135614|Xanthomonadales	M	transferase	waaA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N
k59_430226_1	794903.OPIT5_05405	8.75e-18	82.8	COG4198@1|root,COG4198@2|Bacteria,46S83@74201|Verrucomicrobia,3K7UU@414999|Opitutae	414999|Opitutae	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
k59_430226_2	1382315.JPOI01000001_gene2055	2.68e-12	67.4	COG0240@1|root,COG0240@2|Bacteria,1TQ5P@1239|Firmicutes,4HAXW@91061|Bacilli,1WFR2@129337|Geobacillus	91061|Bacilli	I	glycerol-3-phosphate catabolic process	gpsA	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0047952,GO:0055114	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_86573_1	1035308.AQYY01000001_gene2343	4.17e-93	285.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,260WY@186807|Peptococcaceae	186801|Clostridia	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
k59_779591_1	1120959.ATXF01000006_gene1918	2.63e-131	397.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4FMAX@85023|Microbacteriaceae	201174|Actinobacteria	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_264969_1	1485544.JQKP01000005_gene306	5.8e-49	167.0	COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,2VIG6@28216|Betaproteobacteria,44W7U@713636|Nitrosomonadales	28216|Betaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_264972_1	998674.ATTE01000001_gene2682	3.39e-70	216.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,1S3ST@1236|Gammaproteobacteria,460J4@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
k59_665645_2	350688.Clos_1080	6.55e-29	114.0	COG0500@1|root,COG2226@2|Bacteria,1V0C5@1239|Firmicutes,24IDC@186801|Clostridia,36P3J@31979|Clostridiaceae	186801|Clostridia	Q	PFAM UbiE COQ5 methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_1780083_2	471853.Bcav_3109	9.7e-79	243.0	COG0101@1|root,COG0101@2|Bacteria,2GJ6C@201174|Actinobacteria	201174|Actinobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_1603680_1	187272.Mlg_0956	5.91e-77	253.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WXNN@135613|Chromatiales	135613|Chromatiales	F	PFAM glycosyl transferase family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_1083684_1	1049564.TevJSym_ab00440	2.41e-121	366.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J8SM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Citrate transporter	sac1	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_1603681_1	1089544.KB912942_gene1763	8.75e-49	176.0	COG1392@1|root,COG1392@2|Bacteria	2|Bacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_86605_1	67373.JOBF01000012_gene3909	1.74e-54	177.0	COG0454@1|root,COG0456@2|Bacteria,2GJJZ@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
k59_547587_1	998674.ATTE01000001_gene1691	4.33e-112	329.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,45ZWN@72273|Thiotrichales	72273|Thiotrichales	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1132680_1	316279.Syncc9902_0933	9.85e-22	98.2	COG0837@1|root,COG0837@2|Bacteria,1G1TJ@1117|Cyanobacteria,1GYCB@1129|Synechococcus	1117|Cyanobacteria	H	Belongs to the bacterial glucokinase family	glk	GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046939,GO:0051156,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
k59_842179_1	471853.Bcav_1874	7.15e-82	259.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_489798_1	1353537.TP2_16750	4.41e-92	280.0	COG4177@1|root,COG4177@2|Bacteria,1NZDF@1224|Proteobacteria,2VF26@28211|Alphaproteobacteria,2XPJH@285107|Thioclava	28211|Alphaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K11961	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
k59_87576_1	765912.Thimo_0794	2.95e-59	207.0	COG2375@1|root,COG2375@2|Bacteria,1QWF4@1224|Proteobacteria,1T59S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
k59_1493253_1	1238182.C882_4545	1.24e-34	139.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2TRJE@28211|Alphaproteobacteria,2JPPB@204441|Rhodospirillales	204441|Rhodospirillales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
k59_1133349_1	1194165.CAJF01000011_gene1035	5.77e-34	121.0	2AY0M@1|root,31Q26@2|Bacteria,2IMBI@201174|Actinobacteria,4FPBJ@85023|Microbacteriaceae	201174|Actinobacteria	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N,SHOCT
k59_1320644_1	69279.BG36_20050	2.01e-07	57.4	COG1589@1|root,COG1589@2|Bacteria,1MY1Q@1224|Proteobacteria,2TQPU@28211|Alphaproteobacteria,43HJI@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	D	Essential cell division protein	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
k59_266223_1	631362.Thi970DRAFT_03738	1.34e-85	258.0	COG3439@1|root,COG3439@2|Bacteria,1REDZ@1224|Proteobacteria,1RPW4@1236|Gammaproteobacteria,1WWHH@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_909424_1	397945.Aave_2022	1.62e-61	214.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria,4ABG1@80864|Comamonadaceae	28216|Betaproteobacteria	G	SMART alpha amylase catalytic sub domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_1430002_1	1249627.D779_0203	2.04e-106	327.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1WW1V@135613|Chromatiales	135613|Chromatiales	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
k59_1430002_2	323261.Noc_0340	9.64e-36	132.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,1RMD9@1236|Gammaproteobacteria,1WWZ4@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
k59_1084586_1	331869.BAL199_02734	2.59e-72	234.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_1430009_1	93220.LV28_00485	4.38e-30	116.0	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2VHTD@28216|Betaproteobacteria,1K2HA@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM molybdopterin binding domain	yfaY	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
k59_1430009_2	765911.Thivi_2158	2.39e-17	79.3	COG0412@1|root,COG0412@2|Bacteria,1RCWF@1224|Proteobacteria,1RY38@1236|Gammaproteobacteria,1WX5X@135613|Chromatiales	135613|Chromatiales	Q	PFAM Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
k59_1258771_1	1211114.ALIP01000048_gene2212	5.59e-33	133.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,1X47B@135614|Xanthomonadales	135614|Xanthomonadales	S	DNA internalization-related competence protein ComEC Rec2	comA	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_607044_1	1121405.dsmv_2612	6.43e-96	291.0	COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,42Q93@68525|delta/epsilon subdivisions,2WKAA@28221|Deltaproteobacteria,2MJ2T@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_138123_1	2340.JV46_17550	4.62e-90	277.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1J4KI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_489819_2	472759.Nhal_2439	1.69e-56	183.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,1WXFG@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
k59_842207_1	76114.ebA3429	2.42e-88	265.0	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2VJA0@28216|Betaproteobacteria,2KXQ7@206389|Rhodocyclales	206389|Rhodocyclales	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_842207_2	1100720.ALKN01000033_gene728	1.76e-15	73.9	COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria,2VJN5@28216|Betaproteobacteria,4AACW@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	drrA	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_1493281_1	1411123.JQNH01000001_gene523	7.4e-131	403.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07239	-	-	-	-	ko00000	2.A.6.1	-	-	ACR_tran
k59_32519_1	472759.Nhal_3943	6.03e-122	367.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1WW41@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_381171_1	1267600.JFGT01000005_gene2544	2.07e-21	97.8	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,3VY1H@53335|Pantoea	1236|Gammaproteobacteria	MU	type I secretion outer membrane protein, TolC family	tolC	GO:0002790,GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008104,GO:0008150,GO:0009279,GO:0009306,GO:0009987,GO:0010033,GO:0014070,GO:0015031,GO:0015075,GO:0015267,GO:0015288,GO:0015318,GO:0015562,GO:0015688,GO:0015711,GO:0015833,GO:0015850,GO:0015891,GO:0015893,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022838,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032940,GO:0032991,GO:0033036,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0042886,GO:0042930,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0046618,GO:0046903,GO:0047485,GO:0050896,GO:0051179,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098796,GO:1901678,GO:1902495,GO:1990195,GO:1990196,GO:1990281,GO:1990351	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	iAPECO1_1312.APECO1_3378,iEC042_1314.EC042_3326,iECOK1_1307.ECOK1_3463	OEP
k59_842213_2	77635.BISU_2177	6.03e-42	150.0	COG0707@1|root,COG0707@2|Bacteria,2GJEM@201174|Actinobacteria,4CYQS@85004|Bifidobacteriales	201174|Actinobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227,6.3.2.8	ko:K01924,ko:K02563	ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112	-	R03193,R05032,R05662	RC00005,RC00049,RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_87619_1	187272.Mlg_2386	2.41e-05	47.0	COG3156@1|root,COG3156@2|Bacteria,1RAQM@1224|Proteobacteria,1S2N8@1236|Gammaproteobacteria,1WZTA@135613|Chromatiales	135613|Chromatiales	U	General secretion pathway protein K	-	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
k59_87619_2	247634.GPB2148_3205	2.4e-34	128.0	COG4795@1|root,COG4795@2|Bacteria,1RJAE@1224|Proteobacteria,1S5ZZ@1236|Gammaproteobacteria,1J79H@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	General secretion pathway protein J	gspJ	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSJ
k59_1722316_1	1158146.KB907132_gene92	9.61e-67	222.0	COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,1MUAK@1224|Proteobacteria,1RPP2@1236|Gammaproteobacteria,1WXM4@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_196714_1	768066.HELO_3578	3.11e-52	173.0	COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,1S2TG@1236|Gammaproteobacteria,1XJCR@135619|Oceanospirillales	135619|Oceanospirillales	S	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_780265_1	93220.LV28_24340	7.24e-88	273.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2VI8D@28216|Betaproteobacteria,1K2BU@119060|Burkholderiaceae	28216|Betaproteobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_1133381_1	987059.RBXJA2T_12732	1.33e-49	176.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,1KIU8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CP	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
k59_909484_1	879212.DespoDRAFT_02816	1.48e-28	119.0	COG0243@1|root,COG0243@2|Bacteria,1R4RR@1224|Proteobacteria,42PA5@68525|delta/epsilon subdivisions,2WM0K@28221|Deltaproteobacteria,2MI3Z@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	qrcB	-	-	ko:K08357	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10150	RC03109	ko00000,ko00001,ko02000	5.A.3.10	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1195020_1	479431.Namu_4438	2.79e-40	145.0	COG0673@1|root,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria,4ESD1@85013|Frankiales	201174|Actinobacteria	G	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_381191_1	1122134.KB893650_gene168	3.37e-86	266.0	COG2126@1|root,COG2126@2|Bacteria,1MXCS@1224|Proteobacteria,1RPCN@1236|Gammaproteobacteria,1XIEA@135619|Oceanospirillales	135619|Oceanospirillales	J	COG1226 Kef-type K transport systems	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans
k59_381191_2	1384054.N790_13800	3.41e-40	139.0	COG3000@1|root,COG3000@2|Bacteria,1R4RM@1224|Proteobacteria,1SAME@1236|Gammaproteobacteria,1XA9M@135614|Xanthomonadales	135614|Xanthomonadales	I	sterol desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_1780822_1	338966.Ppro_0397	1.53e-15	78.2	2DKXW@1|root,30TMD@2|Bacteria,1R3IE@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF4410)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4410
k59_1493316_1	1353537.TP2_14225	4.99e-73	244.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,2XM4U@285107|Thioclava	28211|Alphaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_489852_1	1123065.ATWL01000009_gene1008	1.31e-118	369.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2GJU7@201174|Actinobacteria	201174|Actinobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
k59_780277_1	1479237.JMLY01000001_gene883	5.16e-74	234.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,1RPA1@1236|Gammaproteobacteria,464WN@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	FMN-dependent dehydrogenase	lldD	-	1.1.2.3	ko:K00101	ko00620,ko01100,map00620,map01100	-	R00196	RC00044	ko00000,ko00001,ko01000	-	-	-	FMN_dh
k59_666404_1	644283.Micau_5114	4.79e-63	199.0	28JRZ@1|root,2Z9HI@2|Bacteria,2H9EF@201174|Actinobacteria,4DD50@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
k59_1722335_2	595593.JREV01000020_gene2059	4.99e-82	257.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,1W93Y@1268|Micrococcaceae	201174|Actinobacteria	T	phosphatase	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	BofC_C,PP2C,PP2C_2
k59_607085_2	768671.ThimaDRAFT_0362	1.66e-73	228.0	COG2863@1|root,COG2863@2|Bacteria,1RBXV@1224|Proteobacteria,1SEAS@1236|Gammaproteobacteria,1X1G7@135613|Chromatiales	135613|Chromatiales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_313941_1	768671.ThimaDRAFT_2241	9.05e-120	369.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1WXI8@135613|Chromatiales	135613|Chromatiales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_196741_1	1123020.AUIE01000002_gene1355	2.52e-27	111.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria,1YCUI@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	Acyl-CoA dehydrogenase N terminal	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_196741_2	1283300.ATXB01000001_gene1279	3.99e-13	66.6	2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SHAU@1236|Gammaproteobacteria,1XFBV@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_909507_1	550540.Fbal_2849	6.11e-21	92.8	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
k59_909507_2	1249627.D779_2632	4.28e-17	74.7	2E7X9@1|root,332BU@2|Bacteria,1N7MD@1224|Proteobacteria,1SDFK@1236|Gammaproteobacteria,1WZ93@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1857824_1	1278307.KB906968_gene2146	1.11e-37	131.0	COG2859@1|root,COG2859@2|Bacteria,1QU0K@1224|Proteobacteria,1RR22@1236|Gammaproteobacteria,2QJ9A@267894|Psychromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF541)	-	-	-	ko:K09797	-	-	-	-	ko00000	-	-	-	SIMPL
k59_1857824_2	420324.KI911972_gene2998	1.23e-73	229.0	COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,2TVNY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
k59_318984_1	713586.KB900536_gene1568	1.95e-131	390.0	COG2170@1|root,COG2170@2|Bacteria,1MXET@1224|Proteobacteria,1RPKZ@1236|Gammaproteobacteria,1WWXK@135613|Chromatiales	135613|Chromatiales	S	glutamate--cysteine ligase	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
k59_318984_2	1123368.AUIS01000019_gene1205	3.81e-156	447.0	COG3608@1|root,COG3608@2|Bacteria,1R784@1224|Proteobacteria,1RRY6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM Succinylglutamate desuccinylase Aspartoacylase	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
k59_1857830_1	880072.Desac_0497	1.24e-43	142.0	2FJKA@1|root,34B9P@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1498867_1	335543.Sfum_3291	1.91e-148	436.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MQ86@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_847189_1	323848.Nmul_A2331	2.82e-87	278.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,372B6@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	dppF	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_553347_2	356851.JOAN01000014_gene1981	4.6e-32	124.0	2CAQZ@1|root,32RRU@2|Bacteria,2ICWM@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1329578_1	768671.ThimaDRAFT_2158	2.24e-72	228.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1WXRN@135613|Chromatiales	135613|Chromatiales	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_1264437_1	631362.Thi970DRAFT_04513	7.49e-104	335.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1WWGW@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM ATP-dependent helicase HrpA	-	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_918286_1	1129374.AJE_15334	2.32e-100	305.0	COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,1S1TG@1236|Gammaproteobacteria,4657D@72275|Alteromonadaceae	1236|Gammaproteobacteria	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_389962_1	794903.OPIT5_06520	1.01e-34	130.0	COG0205@1|root,COG0205@2|Bacteria,46SFN@74201|Verrucomicrobia,3K7HI@414999|Opitutae	414999|Opitutae	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_142977_1	479434.Sthe_2696	1.57e-23	99.4	COG0114@1|root,COG0114@2|Bacteria,2GBNI@200795|Chloroflexi	200795|Chloroflexi	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_142980_1	1095767.CAHD01000170_gene2529	1.09e-39	147.0	COG0455@1|root,COG0455@2|Bacteria,2IARP@201174|Actinobacteria,4F1X2@85016|Cellulomonadaceae	201174|Actinobacteria	D	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
k59_1435077_1	1304883.KI912532_gene3186	8.38e-07	51.2	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,2VHPG@28216|Betaproteobacteria,2KU8U@206389|Rhodocyclales	206389|Rhodocyclales	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
k59_671213_1	1117647.M5M_18345	4.65e-30	124.0	COG2273@1|root,COG2273@2|Bacteria,1NFHX@1224|Proteobacteria,1RRPK@1236|Gammaproteobacteria,1J8VU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Beta-glucanase Beta-glucan synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16
k59_273309_1	1122611.KB903996_gene7572	6.05e-57	193.0	COG0056@1|root,COG0056@2|Bacteria,2GJRJ@201174|Actinobacteria,4EG2U@85012|Streptosporangiales	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_40030_1	1128421.JAGA01000001_gene2213	5.35e-70	226.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
k59_390006_1	1209072.ALBT01000047_gene458	9.4e-16	73.9	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,1FH8N@10|Cellvibrio	1236|Gammaproteobacteria	S	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate	kdsC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008781,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016311,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016791,GO:0019143,GO:0033692,GO:0034637,GO:0034645,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iECO26_1355.ECO26_4302	Hydrolase_3
k59_390006_2	589865.DaAHT2_1326	7.63e-17	79.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,42M61@68525|delta/epsilon subdivisions,2WIXU@28221|Deltaproteobacteria,2MHNJ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
k59_1857890_1	1336208.JADY01000001_gene954	4.54e-22	99.8	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
k59_273314_2	690850.Desaf_0605	1e-24	103.0	COG4099@1|root,COG4099@2|Bacteria,1RHBS@1224|Proteobacteria,431BR@68525|delta/epsilon subdivisions,2WX0J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
k59_918333_1	886293.Sinac_2995	6.68e-16	80.5	COG1538@1|root,COG1538@2|Bacteria,2IX1X@203682|Planctomycetes	203682|Planctomycetes	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_918333_2	207954.MED92_11364	1.97e-25	109.0	COG0845@1|root,COG0845@2|Bacteria,1R4JA@1224|Proteobacteria,1RPS5@1236|Gammaproteobacteria,1XJG3@135619|Oceanospirillales	135619|Oceanospirillales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_784493_1	1184609.KILIM_092_00090	1.52e-69	225.0	COG4320@1|root,COG4320@2|Bacteria,2GKEK@201174|Actinobacteria	201174|Actinobacteria	K	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
k59_40043_1	1713.JOFV01000001_gene2052	3.45e-32	125.0	COG0477@1|root,COG0477@2|Bacteria,2GK06@201174|Actinobacteria,4F0XY@85016|Cellulomonadaceae	201174|Actinobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_319031_1	1415779.JOMH01000001_gene158	3.48e-24	106.0	COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,1RPY8@1236|Gammaproteobacteria,1X47V@135614|Xanthomonadales	135614|Xanthomonadales	M	Protein of unknown function (DUF1302)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1302
k59_918347_1	1121405.dsmv_1508	8.22e-90	275.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,2MHKB@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
k59_729761_1	1408473.JHXO01000013_gene594	2.39e-154	444.0	COG1350@1|root,COG1350@2|Bacteria,4PKSY@976|Bacteroidetes,2FMFD@200643|Bacteroidia	976|Bacteroidetes	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1435103_1	225937.HP15_3947	3.3e-74	231.0	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,1RQAV@1236|Gammaproteobacteria,4669J@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	walR	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_201560_1	768671.ThimaDRAFT_3176	4.97e-109	350.0	COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,1T1YN@1236|Gammaproteobacteria,1X2UA@135613|Chromatiales	135613|Chromatiales	T	Bacterial periplasmic substrate-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg,SBP_bac_3
k59_977455_1	1454010.JEOE01000033_gene2937	5.59e-138	426.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4F0VV@85016|Cellulomonadaceae	201174|Actinobacteria	C	of components of various dehydrogenase complexes	kgd	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1248c	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_40060_1	34506.g5636	1.18e-38	142.0	COG0151@1|root,COG0299@1|root,KOG0237@2759|Eukaryota,KOG3076@2759|Eukaryota,38BPB@33154|Opisthokonta,3BDXA@33208|Metazoa,3CXAA@33213|Bilateria,40DAY@6231|Nematoda,1KYU2@119089|Chromadorea,40X1E@6236|Rhabditida	33208|Metazoa	F	Trifunctional purine biosynthetic protein adenosine-3	-	-	2.1.2.2,6.3.3.1,6.3.4.13	ko:K11787	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R04144,R04208,R04325,R04326	RC00026,RC00090,RC00166,RC00197,RC01100,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,Formyl_trans_N,GARS_A,GARS_C,GARS_N
k59_40060_2	1235457.C404_16470	2.88e-112	324.0	COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,2VIJ0@28216|Betaproteobacteria,1K38F@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
k59_40060_3	545276.KB898724_gene2012	7.16e-22	94.4	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1WX3A@135613|Chromatiales	135613|Chromatiales	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_847241_1	472759.Nhal_0092	5.57e-81	266.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWNH@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_143018_1	395019.Bmul_6186	2.27e-94	286.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2VI1H@28216|Betaproteobacteria,1K3UX@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_1329687_2	1454010.JEOE01000003_gene282	3.07e-54	175.0	COG1846@1|root,COG1846@2|Bacteria,2IMUX@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
k59_1329687_3	234621.RER_26410	6.74e-44	151.0	COG1321@1|root,COG1321@2|Bacteria,2GK7P@201174|Actinobacteria,4FWQ0@85025|Nocardiaceae	201174|Actinobacteria	K	FeoA	sirR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
k59_96623_2	666686.B1NLA3E_16730	3.76e-26	108.0	COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,4H9RK@91061|Bacilli,1ZB6M@1386|Bacillus	91061|Bacilli	NU	twitching motility protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_1857949_1	861208.AGROH133_04165	7.18e-27	106.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,2TS0N@28211|Alphaproteobacteria,4B9PM@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
k59_977479_1	690850.Desaf_1252	1.99e-49	170.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,43BFQ@68525|delta/epsilon subdivisions,2X6U4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	pfam fad	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_847250_1	397278.JOJN01000002_gene687	3.47e-23	97.8	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4DP2B@85009|Propionibacteriales	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
k59_847250_2	1120971.AUCA01000011_gene2978	4.3e-17	85.1	COG4974@1|root,COG4974@2|Bacteria,1TPQB@1239|Firmicutes,4HARA@91061|Bacilli,2789H@186823|Alicyclobacillaceae	91061|Bacilli	D	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_273356_2	57918.XP_004298814.1	9.16e-18	85.9	COG0308@1|root,KOG1046@2759|Eukaryota,37HGG@33090|Viridiplantae,3GB72@35493|Streptophyta,4JKPW@91835|fabids	35493|Streptophyta	EO	Aminopeptidase	-	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
k59_553417_1	1463934.JOCF01000050_gene7633	3.31e-42	155.0	COG5002@1|root,COG5002@2|Bacteria,2GP6S@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_847254_1	367299.JOEE01000002_gene2488	1.44e-63	203.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria,4FGY3@85021|Intrasporangiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family	-	-	-	ko:K02405,ko:K03090	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_494813_1	933262.AXAM01000005_gene2515	1.63e-23	92.4	COG1886@1|root,COG1886@2|Bacteria,1RGWT@1224|Proteobacteria,42TQB@68525|delta/epsilon subdivisions,2WQCQ@28221|Deltaproteobacteria,2MKA6@213118|Desulfobacterales	28221|Deltaproteobacteria	N	Flagellar motor switch protein FliN	fliN	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
k59_494813_2	933262.AXAM01000005_gene2514	5.1e-20	86.3	2DF9M@1|root,2ZR0E@2|Bacteria	2|Bacteria	N	Flagellar biosynthesis protein, FliO	-	-	-	-	-	-	-	-	-	-	-	-	FliO
k59_390093_1	1408473.JHXO01000009_gene3409	1.03e-74	242.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,4NG9R@976|Bacteroidetes,2FMJF@200643|Bacteroidia	976|Bacteroidetes	C	glutamate synthase (NADPH)	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3
k59_143036_1	323261.Noc_2659	2.48e-26	101.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria,1WY5P@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
k59_143036_2	1123073.KB899243_gene703	8.76e-37	129.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,1X6H0@135614|Xanthomonadales	135614|Xanthomonadales	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
k59_1137911_1	1123277.KB893173_gene1731	0.00016	42.7	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	cccE	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_390100_1	519989.ECTPHS_06197	5.24e-19	92.8	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,1SZ0N@1236|Gammaproteobacteria,1X2J4@135613|Chromatiales	135613|Chromatiales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
k59_390104_1	472759.Nhal_2957	4.5e-61	210.0	COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,1RQ12@1236|Gammaproteobacteria,1WXC8@135613|Chromatiales	1224|Proteobacteria	O	Belongs to the heat shock protein 70 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3731,HSP70
k59_1550938_1	398580.Dshi_2295	1.36e-31	121.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_977522_1	768671.ThimaDRAFT_1852	1.21e-13	67.0	2ETHX@1|root,33M1T@2|Bacteria,1NGGA@1224|Proteobacteria,1SGP8@1236|Gammaproteobacteria,1X17A@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_977522_2	1246459.KB898353_gene565	6.8e-08	55.1	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,2TUSJ@28211|Alphaproteobacteria,4BC9E@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_494822_1	1127134.NOCYR_5101	2.85e-15	72.0	2APG6@1|root,31EJ1@2|Bacteria,2HI1B@201174|Actinobacteria,4G280@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF222
k59_494822_2	1304865.JAGF01000001_gene1664	1.58e-74	233.0	COG1477@1|root,COG1477@2|Bacteria,2GN6F@201174|Actinobacteria	201174|Actinobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_436046_1	1485544.JQKP01000011_gene740	3.14e-13	68.9	COG0676@1|root,COG0676@2|Bacteria,1Q7VN@1224|Proteobacteria,2VKZK@28216|Betaproteobacteria,44V5J@713636|Nitrosomonadales	28216|Betaproteobacteria	G	Belongs to the glucose-6-phosphate 1-epimerase family	-	-	5.1.3.15	ko:K01792	ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130	-	R02739	RC00563	ko00000,ko00001,ko01000	-	-	-	Aldose_epim
k59_436046_2	472759.Nhal_3413	1.42e-32	122.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1S032@1236|Gammaproteobacteria,1X250@135613|Chromatiales	135613|Chromatiales	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_977531_1	99598.Cal7507_5267	2.09e-31	127.0	COG2199@1|root,COG4252@1|root,COG2199@2|Bacteria,COG4252@2|Bacteria,1G17N@1117|Cyanobacteria,1HK0G@1161|Nostocales	1117|Cyanobacteria	T	Diguanylate cyclase with PAS PAC and Chase2 sensors	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,GGDEF,PAS,PAS_4
k59_273381_2	292415.Tbd_2456	1.5e-79	247.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2VHBP@28216|Betaproteobacteria,1KRF9@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_390123_1	748247.AZKH_1239	4.39e-88	268.0	COG0370@1|root,COG0370@2|Bacteria,1NAP4@1224|Proteobacteria,2VNQT@28216|Betaproteobacteria,2KVPS@206389|Rhodocyclales	206389|Rhodocyclales	P	Transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_143751_1	494419.ALPM01000004_gene1773	1e-05	46.2	COG1846@1|root,COG1846@2|Bacteria,2IMGG@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_24,MarR_2
k59_1091223_1	439235.Dalk_2505	3.73e-56	187.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2MI5G@213118|Desulfobacterales	28221|Deltaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_1091223_2	439235.Dalk_3253	7.21e-47	160.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,2MHVQ@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_1138526_1	690850.Desaf_0858	1.91e-109	323.0	COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,42M12@68525|delta/epsilon subdivisions,2WIJX@28221|Deltaproteobacteria,2M7SU@213115|Desulfovibrionales	28221|Deltaproteobacteria	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
k59_495522_1	380394.Lferr_0626	1.79e-143	417.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,2NCJG@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Glutamine synthetase, catalytic domain	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_1331021_1	187272.Mlg_0116	5.86e-66	214.0	COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,1RQQA@1236|Gammaproteobacteria,1X0G6@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_1331021_2	180281.CPCC7001_2735	5.28e-28	113.0	COG5361@1|root,COG5361@2|Bacteria,1G49Q@1117|Cyanobacteria,22TNQ@167375|Cyanobium	1117|Cyanobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1728213_1	243159.AFE_3158	1.92e-46	166.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,2NCH1@225057|Acidithiobacillales	225057|Acidithiobacillales	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HSP90
k59_1728213_2	314278.NB231_06960	1.94e-21	89.7	COG2761@1|root,COG2761@2|Bacteria	2|Bacteria	Q	protein disulfide oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
k59_1091230_1	553385.JEMF01000069_gene1190	1.75e-42	154.0	COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,1RQQA@1236|Gammaproteobacteria,1XKYJ@135619|Oceanospirillales	135619|Oceanospirillales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_391368_1	1415779.JOMH01000001_gene183	8.97e-38	141.0	28MBM@1|root,2ZAQ2@2|Bacteria,1R5V6@1224|Proteobacteria,1S0K0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_923532_1	398767.Glov_0865	1.5e-61	191.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42TFE@68525|delta/epsilon subdivisions,2WPDR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	hdrG	-	-	-	-	-	-	-	-	-	-	-	FlpD
k59_923532_2	398767.Glov_0864	3.29e-19	87.0	COG1148@1|root,COG1148@2|Bacteria,1QUMN@1224|Proteobacteria,43BMA@68525|delta/epsilon subdivisions,2X6ZG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	hdrA	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,FlpD,Pyr_redox_2
k59_1377956_1	1499967.BAYZ01000009_gene5392	7.71e-95	292.0	COG2719@1|root,COG2719@2|Bacteria	2|Bacteria	S	cellular response to DNA damage stimulus	spoVR	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
k59_146146_1	369723.Strop_2131	1.54e-93	289.0	COG5002@1|root,COG5002@2|Bacteria,2I2DU@201174|Actinobacteria,4DMNT@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_1334823_1	935839.JAGJ01000002_gene864	2.09e-136	401.0	COG3920@1|root,COG3920@2|Bacteria,2GKMP@201174|Actinobacteria,4F38N@85017|Promicromonosporaceae	201174|Actinobacteria	T	Histidine kinase	pdtaS	GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K00936	-	M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,H_kinase_N,HisKA_2,PAS_4
k59_277643_1	1265505.ATUG01000001_gene4512	2.32e-103	308.0	COG0462@1|root,COG0462@2|Bacteria,1R2XV@1224|Proteobacteria,42MD5@68525|delta/epsilon subdivisions,2WK1E@28221|Deltaproteobacteria,2MHPM@213118|Desulfobacterales	28221|Deltaproteobacteria	EF	Phosphoribosyl synthetase-associated domain	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_439100_1	438753.AZC_3643	8.82e-27	109.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2TS6C@28211|Alphaproteobacteria,3EYJC@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_395110_1	29073.XP_008688440.1	3.74e-47	168.0	COG0183@1|root,KOG1390@2759|Eukaryota,38C4X@33154|Opisthokonta,3BFH7@33208|Metazoa,3CS6N@33213|Bilateria,481E7@7711|Chordata,49268@7742|Vertebrata,3JAYX@40674|Mammalia,3EJGS@33554|Carnivora	33208|Metazoa	I	acetyl-CoA acetyltransferase	ACAT1	GO:0001655,GO:0001656,GO:0001822,GO:0001889,GO:0003674,GO:0003824,GO:0003985,GO:0003988,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0006082,GO:0006084,GO:0006085,GO:0006090,GO:0006091,GO:0006139,GO:0006163,GO:0006164,GO:0006195,GO:0006520,GO:0006549,GO:0006550,GO:0006629,GO:0006631,GO:0006633,GO:0006635,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0008150,GO:0008152,GO:0008610,GO:0009056,GO:0009058,GO:0009062,GO:0009063,GO:0009081,GO:0009083,GO:0009108,GO:0009109,GO:0009117,GO:0009150,GO:0009152,GO:0009154,GO:0009165,GO:0009166,GO:0009259,GO:0009260,GO:0009261,GO:0009605,GO:0009719,GO:0009725,GO:0009888,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0015936,GO:0015937,GO:0016042,GO:0016043,GO:0016053,GO:0016054,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0016829,GO:0016830,GO:0016874,GO:0016885,GO:0017144,GO:0018130,GO:0019395,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0022607,GO:0030258,GO:0031667,GO:0031974,GO:0032501,GO:0032502,GO:0032787,GO:0033865,GO:0033866,GO:0033869,GO:0033875,GO:0034030,GO:0034031,GO:0034032,GO:0034033,GO:0034034,GO:0034404,GO:0034440,GO:0034641,GO:0034654,GO:0034655,GO:0035295,GO:0035337,GO:0035383,GO:0035384,GO:0042221,GO:0042579,GO:0042594,GO:0042737,GO:0042802,GO:0042803,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044270,GO:0044271,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046356,GO:0046390,GO:0046394,GO:0046395,GO:0046434,GO:0046483,GO:0046700,GO:0046949,GO:0046950,GO:0046951,GO:0046952,GO:0046983,GO:0048037,GO:0048513,GO:0048731,GO:0048732,GO:0048856,GO:0050662,GO:0050896,GO:0051186,GO:0051187,GO:0051188,GO:0051259,GO:0051260,GO:0055086,GO:0055114,GO:0060322,GO:0060429,GO:0060612,GO:0061008,GO:0061326,GO:0061448,GO:0065003,GO:0070013,GO:0071616,GO:0071704,GO:0071840,GO:0072001,GO:0072006,GO:0072009,GO:0072014,GO:0072019,GO:0072073,GO:0072080,GO:0072170,GO:0072207,GO:0072229,GO:0072234,GO:0072237,GO:0072243,GO:0072329,GO:0072330,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901568,GO:1901569,GO:1901570,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902224,GO:1902858,GO:1902860	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	DUF836,Thiolase_C,Thiolase_N
k59_146149_1	1123368.AUIS01000022_gene1060	1.89e-147	436.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,2NBV0@225057|Acidithiobacillales	225057|Acidithiobacillales	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_146149_2	1033802.SSPSH_000349	4.83e-17	81.6	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_1438099_1	644968.DFW101_2770	4.51e-81	271.0	COG0457@1|root,COG2227@1|root,COG0457@2|Bacteria,COG2227@2|Bacteria,1MVMG@1224|Proteobacteria,42WHV@68525|delta/epsilon subdivisions,2WSI4@28221|Deltaproteobacteria,2MA6Q@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,TPR_1,TPR_16,TPR_2,TPR_4,TPR_8
k59_1334859_1	631362.Thi970DRAFT_02375	2.14e-48	167.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria,1WXS3@135613|Chromatiales	135613|Chromatiales	S	Flavocytochrome c sulphide dehydrogenase, flavin-binding	-	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.8.2.3	ko:K17229	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2,TAT_signal
k59_1787684_1	1267005.KB911259_gene3698	2.78e-73	231.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQXI@28211|Alphaproteobacteria,3N61B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	5-aminolevulinic acid synthase	hemA	-	2.3.1.37	ko:K00643	ko00260,ko00860,ko01100,ko01110,map00260,map00860,map01100,map01110	-	R00830	RC00004,RC02815	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1021864_1	349124.Hhal_1117	1.54e-33	128.0	COG1524@1|root,COG1524@2|Bacteria,1R2II@1224|Proteobacteria,1RQDZ@1236|Gammaproteobacteria,1X2CP@135613|Chromatiales	135613|Chromatiales	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
k59_1377982_2	1033802.SSPSH_003096	7.31e-18	76.6	COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the universal ribosomal protein uL29 family	rpmC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
k59_1377982_3	518766.Rmar_0851	5.94e-29	106.0	COG0186@1|root,COG0186@2|Bacteria,4NSB2@976|Bacteroidetes,1FJGB@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
k59_395145_1	1095767.CAHD01000197_gene513	4.24e-81	256.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4F127@85016|Cellulomonadaceae	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1093857_1	243231.GSU1394	8.19e-31	125.0	COG1874@1|root,COG2132@1|root,COG1874@2|Bacteria,COG2132@2|Bacteria,1R9AF@1224|Proteobacteria,42YQG@68525|delta/epsilon subdivisions,2WTP2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Multicopper oxidase	ompB	-	-	-	-	-	-	-	-	-	-	-	ASH,Cu-oxidase_2
k59_1203038_2	1255043.TVNIR_0413	4.69e-05	48.1	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales	135613|Chromatiales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_1021868_1	879212.DespoDRAFT_02308	6.68e-106	322.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,42M90@68525|delta/epsilon subdivisions,2WJ9G@28221|Deltaproteobacteria,2MHV2@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_1268099_1	933262.AXAM01000028_gene3316	3.04e-107	322.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,42MJ9@68525|delta/epsilon subdivisions,2WJH8@28221|Deltaproteobacteria,2MI0K@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_850189_1	1151061.CAJY01000007_gene2895	8e-83	262.0	COG1115@1|root,COG1115@2|Bacteria,2GIU2@201174|Actinobacteria	201174|Actinobacteria	E	amino acid carrier protein	agcS_1	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_1673054_2	1121448.DGI_0268	1.27e-30	114.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,42SNY@68525|delta/epsilon subdivisions,2WP2P@28221|Deltaproteobacteria,2MBQJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
k59_44665_1	572477.Alvin_0126	1.74e-58	192.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1WX5B@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_44665_2	1137799.GZ78_18965	1.85e-11	61.6	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,1XJJI@135619|Oceanospirillales	135619|Oceanospirillales	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
k59_1140432_1	1049564.TevJSym_af00060	4.75e-98	296.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RNPX@1236|Gammaproteobacteria,1J5BW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	ABC transporter	fbpC	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
k59_556452_2	1232437.KL662050_gene5370	4.25e-78	243.0	COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42P2Q@68525|delta/epsilon subdivisions,2WKC2@28221|Deltaproteobacteria,2MJCP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Polysulphide reductase, NrfD	hmcC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	NrfD
k59_44672_1	402626.Rpic_0417	2.94e-110	342.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,1K20S@119060|Burkholderiaceae	28216|Betaproteobacteria	I	acyl-CoA dehydrogenase	fadE	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_1268106_1	1168034.FH5T_08145	1.55e-81	259.0	COG1404@1|root,COG1404@2|Bacteria,4NF1M@976|Bacteroidetes,2FQRG@200643|Bacteroidia	976|Bacteroidetes	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_1553928_1	1120963.KB894512_gene2474	5.12e-18	85.1	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,2Q03Y@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	protein containing LysM domain	lysM	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_923618_1	236097.ADG881_620	1.85e-89	289.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1XIQV@135619|Oceanospirillales	135619|Oceanospirillales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1140438_1	999141.GME_00045	1.82e-31	117.0	COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,1RU35@1236|Gammaproteobacteria,1XID0@135619|Oceanospirillales	135619|Oceanospirillales	K	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	degU	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1140438_2	639283.Snov_0081	1.75e-32	129.0	COG0591@1|root,COG0642@1|root,COG0784@1|root,COG0591@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,3EYE9@335928|Xanthobacteraceae	28211|Alphaproteobacteria	T	histidine kinase A domain protein	MA20_19630	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
k59_1553932_1	765912.Thimo_0342	2.72e-112	333.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1WW0I@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_1502540_1	1163617.SCD_n01585	1.65e-89	278.0	COG1032@1|root,COG1032@2|Bacteria,1MUMS@1224|Proteobacteria,2VZ32@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_1438132_1	1249627.D779_0870	4.94e-74	227.0	COG0693@1|root,COG0693@2|Bacteria,1N7T2@1224|Proteobacteria,1RSBI@1236|Gammaproteobacteria,1WY2E@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM DJ-1 family protein	-	-	3.5.1.124	ko:K03152	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
k59_1268119_1	931276.Cspa_c10980	1.32e-43	155.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,36F7S@31979|Clostridiaceae	186801|Clostridia	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
k59_1334916_1	118161.KB235922_gene928	8.32e-96	293.0	COG1171@1|root,COG1171@2|Bacteria,1GC9C@1117|Cyanobacteria,3VIVG@52604|Pleurocapsales	1117|Cyanobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_4,PALP
k59_1553940_1	1122604.JONR01000022_gene678	1.17e-68	222.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RYB9@1236|Gammaproteobacteria,1X37U@135614|Xanthomonadales	135614|Xanthomonadales	EGP	Major facilitator superfamily	tetA	-	-	ko:K08151	-	M00668	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75	-	-	MFS_1,Sugar_tr
k59_395185_1	478801.Ksed_09660	4.19e-19	85.5	COG0040@1|root,COG0040@2|Bacteria,2GNAX@201174|Actinobacteria,1ZW4Z@145357|Dermacoccaceae	201174|Actinobacteria	E	ATP phosphoribosyltransferase	hisG	GO:0000105,GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003879,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016020,GO:0016053,GO:0016208,GO:0016740,GO:0016757,GO:0016763,GO:0017076,GO:0018130,GO:0019438,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0052803,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
k59_395185_2	1131451.O1K_07852	4.87e-24	95.1	COG4496@1|root,COG4496@2|Bacteria,1NAAX@1224|Proteobacteria,1SG3S@1236|Gammaproteobacteria,1X7DY@135614|Xanthomonadales	135614|Xanthomonadales	S	protein, YerC YecD	-	-	-	-	-	-	-	-	-	-	-	-	Trp_repressor
k59_395185_3	1123073.KB899241_gene3329	8.88e-24	100.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RXCB@1236|Gammaproteobacteria,1X4WJ@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the AB hydrolase superfamily. MetX family	metXS	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_1612617_1	237368.SCABRO_01228	8.8e-19	90.9	COG0180@1|root,COG0180@2|Bacteria,2IWRB@203682|Planctomycetes	203682|Planctomycetes	J	Tryptophanyl-tRNA synthetase	-	-	-	-	-	-	-	-	-	-	-	-	tRNA-synt_1b
k59_1335669_1	857087.Metme_4126	1.54e-40	144.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,1XDMX@135618|Methylococcales	135618|Methylococcales	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	cyoE	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_1335669_2	1122236.KB905144_gene2397	5.15e-15	76.3	COG1999@1|root,COG1999@2|Bacteria,1N6R6@1224|Proteobacteria,2VXI0@28216|Betaproteobacteria,2KMZH@206350|Nitrosomonadales	206350|Nitrosomonadales	S	signal sequence binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_102484_1	472759.Nhal_3451	5.45e-32	120.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1WXGX@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
k59_787419_1	631362.Thi970DRAFT_02362	5.08e-51	183.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,1WW62@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1864006_1	1069080.KB913028_gene987	2.67e-75	236.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,4H2A2@909932|Negativicutes	909932|Negativicutes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_1438601_1	367336.OM2255_11130	1.46e-51	177.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2TRXF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_102494_1	1499967.BAYZ01000028_gene1272	1.27e-55	185.0	COG1995@1|root,COG1995@2|Bacteria,2NNWZ@2323|unclassified Bacteria	2|Bacteria	H	Pyridoxal phosphate biosynthetic protein PdxA	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1357_C,DUF1537,PdxA
k59_1554435_1	1463887.KL590039_gene5736	3.26e-78	239.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_1378536_1	1049564.TevJSym_aj00230	6.19e-95	286.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1J54C@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iECS88_1305.ECS88_0100	LpxC
k59_1378536_2	631362.Thi970DRAFT_02120	0.000144	45.1	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1WXJ6@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_850692_1	1108045.GORHZ_247_00020	5.36e-47	160.0	COG1061@1|root,COG1061@2|Bacteria,2H66X@201174|Actinobacteria	201174|Actinobacteria	KL	Type III restriction enzyme res subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_102503_1	471853.Bcav_2743	3.83e-148	437.0	COG1061@1|root,COG1061@2|Bacteria,2GIU5@201174|Actinobacteria	201174|Actinobacteria	L	type III restriction enzyme, res subunit	sdrA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ResIII
k59_787427_1	342610.Patl_2870	6.82e-13	73.2	COG0845@1|root,COG0845@2|Bacteria,1R4JA@1224|Proteobacteria,1RPS5@1236|Gammaproteobacteria,2PZKY@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_1140847_1	1121374.KB891578_gene3227	1.19e-36	135.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria	1224|Proteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_1730959_1	745776.DGo_CA2456	9.44e-59	194.0	COG2896@1|root,COG2896@2|Bacteria,1WIGS@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
k59_1268626_1	326442.PSHAb0081	1.02e-37	139.0	COG1015@1|root,COG1015@2|Bacteria,1MVN8@1224|Proteobacteria,1RQ6W@1236|Gammaproteobacteria,2PZT6@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	G	Phosphotransfer between the C1 and C5 carbon atoms of pentose	deoB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008973,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	iLF82_1304.LF82_0465,iNRG857_1313.NRG857_22165	Metalloenzyme
k59_1268626_2	264462.Bd0085	2.1e-05	45.4	COG0590@1|root,COG0590@2|Bacteria,1RHM4@1224|Proteobacteria,42SH2@68525|delta/epsilon subdivisions,2MUI0@213481|Bdellovibrionales,2WQ49@28221|Deltaproteobacteria	213481|Bdellovibrionales	FJ	deaminase	-	-	-	-	-	-	-	-	-	-	-	-	MafB19-deam,dCMP_cyt_deam_1
k59_1612640_1	717785.HYPMC_0407	5.85e-22	95.5	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,2TTRG@28211|Alphaproteobacteria,3N90C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1612640_2	713586.KB900536_gene2384	6.04e-80	244.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,1SZEH@1236|Gammaproteobacteria,1X2JX@135613|Chromatiales	135613|Chromatiales	Q	Hypothetical methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_1673581_1	368407.Memar_1426	1.51e-47	166.0	COG1055@1|root,arCOG00238@2157|Archaea,2XVDU@28890|Euryarchaeota,2N961@224756|Methanomicrobia	224756|Methanomicrobia	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_498404_1	1121930.AQXG01000005_gene676	6.23e-20	94.0	COG2234@1|root,COG2234@2|Bacteria,4NFDJ@976|Bacteroidetes,1IV5U@117747|Sphingobacteriia	976|Bacteroidetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_674988_1	1121918.ARWE01000001_gene974	5.81e-101	301.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,43BDC@68525|delta/epsilon subdivisions,2WK43@28221|Deltaproteobacteria	28221|Deltaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	aapJ	-	-	ko:K09969	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
k59_983553_1	1177179.A11A3_15672	4.08e-46	155.0	COG3897@1|root,COG3897@2|Bacteria,1RJUI@1224|Proteobacteria,1S6V9@1236|Gammaproteobacteria,1XKCT@135619|Oceanospirillales	135619|Oceanospirillales	S	COG2230 Cyclopropane fatty acid synthase and related methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_16,Methyltransf_25
k59_396034_1	497321.C664_08523	1.39e-55	191.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2VH94@28216|Betaproteobacteria,2KVMS@206389|Rhodocyclales	206389|Rhodocyclales	OU	signal peptide peptidase	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_1203540_1	90814.KL370892_gene2326	7.84e-115	345.0	COG0699@1|root,COG0699@2|Bacteria,1MV59@1224|Proteobacteria,1RYGW@1236|Gammaproteobacteria,46275@72273|Thiotrichales	72273|Thiotrichales	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_205303_2	56780.SYN_03230	3.24e-57	192.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,42P1M@68525|delta/epsilon subdivisions,2WKJ2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM peptidase M48 Ste24p	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
k59_498413_1	439235.Dalk_5090	3.27e-43	157.0	COG1018@1|root,COG1148@1|root,COG1018@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
k59_498413_2	903818.KI912269_gene59	1.76e-17	81.6	COG1894@1|root,COG1894@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	hymB	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00335,ko:K18331,ko:K22339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_146734_2	1476876.JOJO01000011_gene3376	1.05e-06	49.7	COG0607@1|root,COG0607@2|Bacteria,2IQJQ@201174|Actinobacteria	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1730977_1	1476973.JMMB01000007_gene2216	1.81e-17	83.6	COG2454@1|root,COG2454@2|Bacteria,1V42I@1239|Firmicutes,24BAF@186801|Clostridia,25T3Z@186804|Peptostreptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF434)	-	-	-	-	-	-	-	-	-	-	-	-	DUF434
k59_983565_1	278957.ABEA03000113_gene549	1.96e-09	55.1	COG0228@1|root,COG0228@2|Bacteria,46WC2@74201|Verrucomicrobia,3K8CM@414999|Opitutae	414999|Opitutae	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
k59_983565_2	639282.DEFDS_0253	2.8e-18	78.6	COG1837@1|root,COG1837@2|Bacteria,2GFZI@200930|Deferribacteres	200930|Deferribacteres	S	KH domain	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
k59_983565_3	1437425.CSEC_2293	0.000718	41.6	COG0336@1|root,COG0336@2|Bacteria,2JFXJ@204428|Chlamydiae	204428|Chlamydiae	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
k59_1864069_1	1121423.JONT01000015_gene1346	8.71e-82	270.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,2600Y@186807|Peptococcaceae	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_210551_1	1297865.APJD01000020_gene155	7.83e-52	166.0	COG4319@1|root,COG4319@2|Bacteria,1PIQU@1224|Proteobacteria,2UXCH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ketosteroid isomerase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_210551_2	292.DM42_6987	6.5e-78	241.0	COG0583@1|root,COG0583@2|Bacteria,1R5NZ@1224|Proteobacteria,2VKZH@28216|Betaproteobacteria,1KBRZ@119060|Burkholderiaceae	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1508876_1	526222.Desal_1131	6.63e-31	120.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,43AD6@68525|delta/epsilon subdivisions,2WJCC@28221|Deltaproteobacteria,2M8PA@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	transporter antisigma-factor antagonist STAS	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_404339_1	1184609.KILIM_042_00100	2.95e-60	207.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,COG1145@2|Bacteria,2I995@201174|Actinobacteria	201174|Actinobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_404339_2	1304865.JAGF01000001_gene2382	2.34e-57	194.0	COG5607@1|root,COG5607@2|Bacteria,2GJZH@201174|Actinobacteria	201174|Actinobacteria	S	CHAD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
k59_1344179_1	367299.JOEE01000004_gene999	1.96e-91	274.0	COG0712@1|root,COG0712@2|Bacteria,2GMJ5@201174|Actinobacteria,4FGII@85021|Intrasporangiaceae	201174|Actinobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02109,ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,OSCP
k59_1559841_1	1479623.JHEL01000015_gene629	9.11e-80	244.0	COG0175@1|root,COG0175@2|Bacteria,2GJ3Z@201174|Actinobacteria,4FMSW@85023|Microbacteriaceae	201174|Actinobacteria	EH	Phosphoadenosine phosphosulfate reductase family	cysH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004604,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016667,GO:0016671,GO:0019344,GO:0019752,GO:0040007,GO:0043436,GO:0043866,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2392	PAPS_reduct
k59_1736152_1	1232437.KL662077_gene1940	1.29e-84	268.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,42NFV@68525|delta/epsilon subdivisions,2WJZ0@28221|Deltaproteobacteria,2MJ41@213118|Desulfobacterales	28221|Deltaproteobacteria	CP	Proton-conducting membrane transporter	ehrA-2	-	-	ko:K12137	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M,Proton_antipo_N
k59_1792733_2	1238190.AMQY01000021_gene1539	2.35e-52	173.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,1RXYF@1236|Gammaproteobacteria,1XHWD@135619|Oceanospirillales	135619|Oceanospirillales	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_1618059_1	1040983.AXAE01000020_gene3492	2.05e-25	105.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2TRSV@28211|Alphaproteobacteria,43I4A@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
k59_1618059_2	322710.Avin_01190	1.06e-20	87.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,1S3VN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016866,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034023,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	iETEC_1333.ETEC_0575,iJN746.PP_5336,iPC815.YPO3076,iUTI89_1310.UTI89_C0551	AIRC
k59_503513_1	1033802.SSPSH_002735	3.45e-50	170.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,1RNGM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	nadp-dependent	yfmJ	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
k59_739016_1	1049564.TevJSym_av00040	3.63e-118	355.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1J5H2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iSFV_1184.SFV_1868	GAD,tRNA-synt_2,tRNA_anti-codon
k59_1344208_1	472759.Nhal_1236	5.03e-46	169.0	COG1033@1|root,COG1033@2|Bacteria,1QW3H@1224|Proteobacteria,1RZA3@1236|Gammaproteobacteria,1X2NT@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM hopanoid biosynthesis associated RND transporter like protein HpnN	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_1384078_1	948565.AFFP02000009_gene571	4.74e-26	110.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1Y845@135625|Pasteurellales	135625|Pasteurellales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_285308_1	519989.ECTPHS_12803	5.93e-117	345.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1WWFM@135613|Chromatiales	135613|Chromatiales	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_991981_1	502025.Hoch_4234	9.74e-60	204.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2YYYV@29|Myxococcales	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_991981_2	1177179.A11A3_01150	2.88e-103	311.0	COG3239@1|root,COG3239@2|Bacteria,1MW29@1224|Proteobacteria,1RPHS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Alkane 1-monooxygenase	alkB1	GO:0003674,GO:0003824,GO:0004497,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016491,GO:0016705,GO:0016713,GO:0018685,GO:0043446,GO:0043448,GO:0044237,GO:0044248,GO:0055114,GO:0071704,GO:1901575	1.14.15.3	ko:K00496	ko00071,ko00930,map00071,map00930	-	R01347,R02281,R06945	RC00478	ko00000,ko00001,ko01000	-	-	-	FA_desaturase
k59_327839_1	999141.GME_16097	2.7e-39	136.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S8RS@1236|Gammaproteobacteria,1XKER@135619|Oceanospirillales	135619|Oceanospirillales	U	Biopolymer transport protein	tolR	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
k59_991987_1	1165841.SULAR_03063	4e-88	265.0	COG2128@1|root,COG2128@2|Bacteria,1PSNE@1224|Proteobacteria,42XCT@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_1559871_2	644282.Deba_2542	2.15e-144	418.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,42N9K@68525|delta/epsilon subdivisions,2WINH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM N-6 DNA methylase	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
k59_503529_1	1278309.KB907105_gene1453	4.51e-16	77.4	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,1XH2P@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_503529_2	1168059.KB899087_gene1817	1.05e-32	117.0	COG1393@1|root,COG1393@2|Bacteria,1MZ6S@1224|Proteobacteria,2U98B@28211|Alphaproteobacteria,3EZS2@335928|Xanthobacteraceae	28211|Alphaproteobacteria	P	ArsC family	MA20_27840	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
k59_404392_1	1049564.TevJSym_ba00330	5.12e-31	117.0	2DB6R@1|root,2Z7I2@2|Bacteria,1R7AG@1224|Proteobacteria,1RQ0D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_404392_2	765912.Thimo_1095	2.25e-33	120.0	COG3737@1|root,COG3737@2|Bacteria,1N083@1224|Proteobacteria,1SD91@1236|Gammaproteobacteria,1X23R@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
k59_932792_1	1126627.BAWE01000006_gene6482	2.57e-51	178.0	COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2TR59@28211|Alphaproteobacteria,3JT7K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_932792_2	1430440.MGMSRv2_3787	7.54e-69	209.0	COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,2U7TH@28211|Alphaproteobacteria,2JT30@204441|Rhodospirillales	204441|Rhodospirillales	L	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k59_52577_2	67267.JNXT01000003_gene4105	1.48e-09	66.6	COG1231@1|root,COG1231@2|Bacteria,2GK23@201174|Actinobacteria	201174|Actinobacteria	E	(mono)amine oxidase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_327855_1	13333.ERM98576	0.000794	45.1	COG1028@1|root,KOG0725@2759|Eukaryota,37RHS@33090|Viridiplantae,3GFNS@35493|Streptophyta	35493|Streptophyta	Q	chlorophyll(ide) b reductase NYC1	NYC1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006787,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009507,GO:0009536,GO:0009987,GO:0010304,GO:0015994,GO:0015996,GO:0016491,GO:0016614,GO:0016616,GO:0019439,GO:0019538,GO:0030163,GO:0033013,GO:0033015,GO:0034256,GO:0034641,GO:0042440,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046149,GO:0046483,GO:0046700,GO:0051186,GO:0051187,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	1.1.1.294	ko:K13606	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R08914,R08915,R09069,R09070	RC00116	ko00000,ko00001,ko01000	-	-	-	adh_short
k59_1384096_1	1122194.AUHU01000005_gene910	5.68e-77	246.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,464M5@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_1618102_1	645465.ACUR01000438_gene1952	1.98e-90	276.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1678862_1	1035308.AQYY01000001_gene2506	6.11e-75	238.0	COG4325@1|root,COG4325@2|Bacteria,1TSID@1239|Firmicutes,24E01@186801|Clostridia	186801|Clostridia	S	Predicted membrane protein (DUF2254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
k59_1274591_1	1266909.AUAG01000041_gene1370	1.53e-64	208.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1WXDA@135613|Chromatiales	135613|Chromatiales	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
k59_1618106_1	1123393.KB891316_gene1152	1.67e-23	99.4	COG3660@1|root,COG3660@2|Bacteria,1RC47@1224|Proteobacteria,2VRI5@28216|Betaproteobacteria,1KSMA@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Mitochondrial fission ELM1	-	-	-	-	-	-	-	-	-	-	-	-	Mito_fiss_Elm1
k59_1618106_2	187272.Mlg_2791	7.58e-27	100.0	COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,1SHHF@1236|Gammaproteobacteria,1WZR6@135613|Chromatiales	135613|Chromatiales	S	Zinc-finger domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-CHCC
k59_444927_2	396588.Tgr7_1047	5.61e-18	79.7	COG1051@1|root,COG1051@2|Bacteria,1RC3I@1224|Proteobacteria,1S34Y@1236|Gammaproteobacteria,1WY35@135613|Chromatiales	135613|Chromatiales	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_1559895_1	1049564.TevJSym_ad00290	4.25e-173	523.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,1J980@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2309)	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k59_1100111_1	159087.Daro_3585	1.18e-109	332.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,2KU63@206389|Rhodocyclales	206389|Rhodocyclales	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_110922_1	1192868.CAIU01000021_gene3031	3.39e-07	51.6	COG3153@1|root,COG3153@2|Bacteria,1RA42@1224|Proteobacteria,2UG08@28211|Alphaproteobacteria,43K3E@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	ko:K03824	-	-	-	-	ko00000,ko01000	-	-	-	ABM,Acetyltransf_1,Acetyltransf_7,Acetyltransf_9
k59_110922_2	1209072.ALBT01000023_gene3905	3.05e-35	123.0	29YN5@1|root,30KHN@2|Bacteria,1Q9TW@1224|Proteobacteria,1TAYX@1236|Gammaproteobacteria,1FIDB@10|Cellvibrio	1236|Gammaproteobacteria	S	Putative prokaryotic signal transducing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
k59_110922_3	338963.Pcar_2292	1.44e-32	115.0	COG1917@1|root,COG1917@2|Bacteria,1MZNT@1224|Proteobacteria,42VFI@68525|delta/epsilon subdivisions,2WR7C@28221|Deltaproteobacteria,43VSF@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM Cupin 2, conserved barrel	-	-	-	ko:K11312	-	-	-	-	ko00000	-	-	-	Cupin_2
k59_1508952_1	1187848.AJYQ01000003_gene410	1.41e-80	255.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGA@1236|Gammaproteobacteria,1XXNF@135623|Vibrionales	135623|Vibrionales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1384116_2	545276.KB898733_gene2547	5.76e-77	252.0	COG1205@1|root,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,1S0XD@1236|Gammaproteobacteria,1WXNC@135613|Chromatiales	135613|Chromatiales	L	DEAD DEAH box	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
k59_680466_2	1397528.Q671_15160	3.14e-60	202.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1XHB9@135619|Oceanospirillales	135619|Oceanospirillales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_1559906_1	1203556.HMPREF1478_01934	3.89e-29	116.0	COG0641@1|root,COG0641@2|Bacteria,2HJI6@201174|Actinobacteria,4D3MC@85005|Actinomycetales	201174|Actinobacteria	C	anaerobic sulfatase maturase	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Radical_SAM,SPASM
k59_562159_2	1045009.AFXQ01000015_gene2484	1.4e-101	304.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,1WAV4@1268|Micrococcaceae	201174|Actinobacteria	C	Dehydrogenase E1 component	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_110942_1	243275.TDE_0111	1.75e-05	49.7	COG1664@1|root,COG1664@2|Bacteria,2J82J@203691|Spirochaetes	203691|Spirochaetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_562160_1	1266909.AUAG01000026_gene1916	1.57e-27	106.0	COG3065@1|root,COG3065@2|Bacteria,1MZ8C@1224|Proteobacteria	1224|Proteobacteria	M	Outer Membrane Lipoprotein	slp	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802	-	ko:K07285	-	-	-	-	ko00000	-	-	-	Slp
k59_1559910_1	582744.Msip34_1300	9.3e-61	196.0	COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,2VIZ9@28216|Betaproteobacteria,2KKWX@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Protein of unknown function (DUF1365)	-	-	-	ko:K09701	-	-	-	-	ko00000	-	-	-	DUF1365
k59_1792802_1	443143.GM18_0341	6.48e-60	205.0	COG2133@1|root,COG2133@2|Bacteria,1NRFC@1224|Proteobacteria,42YAV@68525|delta/epsilon subdivisions,2WTUF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_210638_1	1123519.PSJM300_13965	1.72e-128	378.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,1YZXI@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1814,iECOK1_1307.ECOK1_0174,iECS88_1305.ECS88_0183,iUMN146_1321.UM146_23670,iUTI89_1310.UTI89_C0188	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_1559913_1	1123368.AUIS01000019_gene1224	6.26e-83	263.0	COG0569@1|root,COG1226@1|root,COG0569@2|Bacteria,COG1226@2|Bacteria,1R3QQ@1224|Proteobacteria,1RPFS@1236|Gammaproteobacteria,2NC05@225057|Acidithiobacillales	225057|Acidithiobacillales	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
k59_932869_2	935839.JAGJ01000005_gene2604	1.79e-17	82.8	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4F43K@85017|Promicromonosporaceae	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1344310_1	1249627.D779_2911	8.01e-120	377.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales	135613|Chromatiales	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_680481_1	1042377.AFPJ01000054_gene1686	8e-96	298.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,469KU@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_285404_1	1248916.ANFY01000009_gene84	6.42e-14	75.1	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2UP03@28211|Alphaproteobacteria,2KDWK@204457|Sphingomonadales	204457|Sphingomonadales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_992075_1	522373.Smlt3855	6.94e-119	345.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1X3QU@135614|Xanthomonadales	135614|Xanthomonadales	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
k59_1384136_1	648757.Rvan_3631	1.1e-116	361.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2TRMJ@28211|Alphaproteobacteria,3N623@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	ATP-dependent helicase	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_855974_1	1550073.JROH01000025_gene1016	5.68e-118	358.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,2K0PZ@204457|Sphingomonadales	204457|Sphingomonadales	E	gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1384143_1	754476.Q7A_676	2.43e-21	87.8	COG3113@1|root,COG3113@2|Bacteria	2|Bacteria	S	response to antibiotic	-	-	-	ko:K07122	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	STAS_2
k59_1384143_2	1123487.KB892865_gene1487	7.71e-20	84.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,2VRKR@28216|Betaproteobacteria,2KWBN@206389|Rhodocyclales	206389|Rhodocyclales	Q	ABC-type transport system involved in resistance to organic solvents, periplasmic component	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_562180_2	1410620.SHLA_13c000230	8.47e-36	127.0	COG0789@1|root,COG0789@2|Bacteria,1N0AZ@1224|Proteobacteria,2UD14@28211|Alphaproteobacteria,4BG6U@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, mercury resistance	merR	-	-	ko:K08365	-	-	-	-	ko00000,ko03000	-	-	-	MerR,MerR-DNA-bind,MerR_1
k59_992096_1	765910.MARPU_05485	7.45e-79	244.0	COG0167@1|root,COG0167@2|Bacteria,1MXER@1224|Proteobacteria,1RRTA@1236|Gammaproteobacteria,1WWCH@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_932895_1	316274.Haur_2656	8.49e-74	248.0	COG1197@1|root,COG1197@2|Bacteria,2G5UW@200795|Chloroflexi,375DR@32061|Chloroflexia	32061|Chloroflexia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_152255_1	634956.Geoth_2521	3.54e-56	194.0	COG1953@1|root,COG1953@2|Bacteria,1TS5W@1239|Firmicutes,4HAIM@91061|Bacilli,1WET4@129337|Geobacillus	91061|Bacilli	FH	Permease for cytosine/purines, uracil, thiamine, allantoin	pucI	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
k59_52667_1	439235.Dalk_1263	5.18e-70	218.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria,2MIHA@213118|Desulfobacterales	28221|Deltaproteobacteria	N	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
k59_285431_2	395493.BegalDRAFT_3295	1.8e-10	62.4	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1T1HN@1236|Gammaproteobacteria,461T8@72273|Thiotrichales	72273|Thiotrichales	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_562691_1	236097.ADG881_1725	4.51e-19	91.7	COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria,1XKA8@135619|Oceanospirillales	135619|Oceanospirillales	D	Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins	zipA	-	-	ko:K03528	-	-	-	-	ko00000,ko03036	-	-	-	ZipA_C
k59_1384646_1	1249627.D779_0777	5.44e-115	353.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,1RPA0@1236|Gammaproteobacteria,1WWBS@135613|Chromatiales	135613|Chromatiales	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
k59_1444394_2	882083.SacmaDRAFT_0352	6.04e-53	178.0	COG0382@1|root,COG0382@2|Bacteria,2GJ6P@201174|Actinobacteria,4DZCS@85010|Pseudonocardiales	201174|Actinobacteria	H	PFAM UbiA prenyltransferase	ubiA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016763,GO:0031224,GO:0031226,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046872,GO:0052636,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.2.45	ko:K14136	-	-	R10095	RC00005	ko00000,ko01000,ko01006	-	-	-	UbiA
k59_562693_1	472759.Nhal_0092	1.03e-95	307.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWNH@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_562693_2	1049564.TevJSym_at00030	4.49e-38	139.0	28I2K@1|root,2Z86N@2|Bacteria,1R1GA@1224|Proteobacteria,1RRPU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_856436_2	765911.Thivi_2349	1.16e-94	281.0	COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,1S37E@1236|Gammaproteobacteria,1WWWB@135613|Chromatiales	135613|Chromatiales	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_621344_2	29495.EA26_13815	9.22e-21	93.2	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1XU1K@135623|Vibrionales	135623|Vibrionales	J	COG0480 Translation elongation factors (GTPases)	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_211168_1	1123065.ATWL01000025_gene1855	1.35e-43	162.0	COG2378@1|root,COG2378@2|Bacteria,2I8XQ@201174|Actinobacteria	201174|Actinobacteria	K	Helicase conserved C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_3
k59_1683533_2	1038869.AXAN01000102_gene4464	3.72e-38	140.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2VJ2W@28216|Betaproteobacteria,1K2WR@119060|Burkholderiaceae	28216|Betaproteobacteria	S	transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_1032599_1	882378.RBRH_03110	5.32e-69	222.0	COG0491@1|root,COG0491@2|Bacteria,1MUXF@1224|Proteobacteria,2VKJX@28216|Betaproteobacteria,1JZU7@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1797078_1	1117647.M5M_10885	1.49e-148	434.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,1J5GX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	alsS	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_292207_1	589865.DaAHT2_0891	1.35e-133	403.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WJRZ@28221|Deltaproteobacteria,2MJ97@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_625821_1	765912.Thimo_0598	8.09e-98	300.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1WW6G@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1105627_1	1267005.KB911255_gene2442	2.77e-56	186.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,3N6HK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Belongs to the thiolase family	phbA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1280040_1	1429851.X548_07075	3.62e-80	268.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X3PQ@135614|Xanthomonadales	135614|Xanthomonadales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	mdtB	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_1514242_1	1379698.RBG1_1C00001G0109	1.35e-58	192.0	COG1108@1|root,COG1108@2|Bacteria,2NQ6F@2323|unclassified Bacteria	2|Bacteria	U	ABC 3 transport family	znuB	-	-	ko:K02075,ko:K09816	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
k59_449914_1	1123368.AUIS01000007_gene2783	4.95e-31	120.0	arCOG05916@1|root,30GTU@2|Bacteria,1RDX8@1224|Proteobacteria,1SNV0@1236|Gammaproteobacteria,2NCJR@225057|Acidithiobacillales	225057|Acidithiobacillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1564532_1	1541065.JRFE01000004_gene5261	3.95e-08	60.5	COG1572@1|root,COG2304@1|root,COG2911@1|root,COG2931@1|root,COG3204@1|root,COG3210@1|root,COG3386@1|root,COG3420@1|root,COG4257@1|root,COG1572@2|Bacteria,COG2304@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3204@2|Bacteria,COG3210@2|Bacteria,COG3386@2|Bacteria,COG3420@2|Bacteria,COG4257@2|Bacteria	2|Bacteria	V	antibiotic catabolic process	-	-	3.4.21.10	ko:K01317,ko:K02674,ko:K07004,ko:K11016,ko:K13277,ko:K20276,ko:K21449	ko02024,ko03070,map02024,map03070	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02000,ko02035,ko02042,ko02044,ko03110,ko04131	1.B.40.2	-	-	Gram_pos_anchor
k59_744098_1	880072.Desac_0826	8.76e-73	233.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1032645_1	1454004.AW11_02751	5.11e-45	159.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,2VH7G@28216|Betaproteobacteria	28216|Betaproteobacteria	M	PFAM secretion protein HlyD family protein	-	-	-	ko:K01993,ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1448582_1	1403819.BATR01000040_gene1207	2.16e-61	210.0	COG0654@1|root,COG2020@1|root,COG0654@2|Bacteria,COG2020@2|Bacteria,46VIV@74201|Verrucomicrobia,2IWBP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_1741410_1	187272.Mlg_1825	4.77e-113	333.0	COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,1WVWC@135613|Chromatiales	135613|Chromatiales	K	TIGRFAM RNA polymerase sigma factor RpoS	rpoS	-	-	ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1741410_2	323848.Nmul_A1553	9.7e-24	93.6	COG3737@1|root,COG3737@2|Bacteria,1N083@1224|Proteobacteria,2VUF2@28216|Betaproteobacteria,373I3@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
k59_333062_1	399742.Ent638_0701	4.54e-59	198.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,3X21Y@547|Enterobacter	1236|Gammaproteobacteria	O	Belongs to the peptidase S1C family	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016020,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	1.3.1.74,3.4.21.107	ko:K04771,ko:K04772,ko:K08070	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
k59_625859_1	1141662.OOA_16394	1.64e-06	54.3	COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,1RPQA@1236|Gammaproteobacteria,3Z8H3@586|Providencia	1236|Gammaproteobacteria	S	Psort location CytoplasmicMembrane, score 10.00	yddA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016021,GO:0017076,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02471	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.203.11,3.A.1.203.4	-	-	ABC_membrane_2,ABC_tran
k59_1280075_1	335543.Sfum_1941	2.07e-107	318.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria,2MR9Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_1149963_2	1049564.TevJSym_ag01050	5.52e-82	248.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1J5V6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_1149963_3	1123514.KB905899_gene1920	1.16e-23	98.2	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,45ZQR@72273|Thiotrichales	72273|Thiotrichales	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_1388786_1	1304865.JAGF01000001_gene1042	1.98e-157	450.0	COG0077@1|root,COG0077@2|Bacteria,2GJQ5@201174|Actinobacteria,4F1IN@85016|Cellulomonadaceae	201174|Actinobacteria	E	amino acid-binding ACT domain protein	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
k59_1514289_1	572547.Amico_1375	7.45e-64	214.0	COG0272@1|root,COG0272@2|Bacteria,3T9WY@508458|Synergistetes	508458|Synergistetes	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_292284_1	306281.AJLK01000073_gene2585	1.27e-134	393.0	COG0787@1|root,COG0787@2|Bacteria,1GCYU@1117|Cyanobacteria,1JMVV@1189|Stigonemataceae	1117|Cyanobacteria	M	Alanine racemase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_1213386_1	1089552.KI911559_gene640	3.17e-110	334.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2TQJA@28211|Alphaproteobacteria,2JP96@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_157213_1	2340.JV46_14270	1.58e-05	46.2	COG1394@1|root,COG1394@2|Bacteria,1RJ1P@1224|Proteobacteria,1S75D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	ATP synthase subunit D	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
k59_157213_2	2340.JV46_14280	1.35e-57	192.0	COG1156@1|root,COG1156@2|Bacteria,1QUQE@1224|Proteobacteria,1T210@1236|Gammaproteobacteria,1JC0C@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_ab
k59_1683613_1	367299.JOEE01000001_gene1823	9.81e-151	434.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,4FFI5@85021|Intrasporangiaceae	201174|Actinobacteria	S	FAD-dependent pyridine nucleotide-disulfide oxidoreductase	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
k59_795648_2	1042377.AFPJ01000052_gene1575	2.08e-15	72.0	COG3100@1|root,COG3100@2|Bacteria,1N83J@1224|Proteobacteria,1SCCD@1236|Gammaproteobacteria,468IY@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	YcgL domain-containing protein	ycgL	-	-	ko:K09902	-	-	-	-	ko00000	-	-	-	YcgL
k59_625894_1	765913.ThidrDRAFT_0134	2.24e-52	172.0	COG3218@1|root,COG3218@2|Bacteria,1N13E@1224|Proteobacteria,1S663@1236|Gammaproteobacteria,1WYRS@135613|Chromatiales	135613|Chromatiales	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K18480	-	M00669	-	-	ko00000,ko00002,ko02000	3.A.1.27.1	-	-	ABC_trans_aux
k59_1622772_1	349124.Hhal_0432	3.75e-37	141.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1WW51@135613|Chromatiales	135613|Chromatiales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_1280113_1	555778.Hneap_1976	2.02e-86	282.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1WX9W@135613|Chromatiales	135613|Chromatiales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
k59_1214555_2	105559.Nwat_0543	1.27e-13	67.4	COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,1SCBI@1236|Gammaproteobacteria,1WZF3@135613|Chromatiales	135613|Chromatiales	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	-	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
k59_1107000_2	1123065.ATWL01000004_gene2940	4.38e-114	340.0	COG4850@1|root,COG4850@2|Bacteria,2GKPS@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2183)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2183
k59_1565618_1	1500893.JQNB01000001_gene1262	2.51e-114	336.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1X3ZT@135614|Xanthomonadales	135614|Xanthomonadales	C	Heme copper-type cytochrome quinol oxidase subunit 3	cox3	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_1565618_2	1469245.JFBG01000016_gene963	1.22e-14	69.3	2EGIJ@1|root,33AAQ@2|Bacteria,1NH9B@1224|Proteobacteria,1SGKJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2909)	VL23_10685	-	-	-	-	-	-	-	-	-	-	-	DUF2909
k59_1150925_1	1385520.N802_05375	1.39e-53	187.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,4FG60@85021|Intrasporangiaceae	201174|Actinobacteria	E	gamma-glutamyltranspeptidase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_796499_2	233412.HD_1815	4.6e-14	70.1	COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,1S5ZA@1236|Gammaproteobacteria,1Y8X0@135625|Pasteurellales	135625|Pasteurellales	P	part of a sulfur-relay system	tusE	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_686470_2	1158146.KB907124_gene2180	1.8e-33	117.0	COG3785@1|root,COG3785@2|Bacteria,1RHM7@1224|Proteobacteria,1T11M@1236|Gammaproteobacteria,1X1AJ@135613|Chromatiales	135613|Chromatiales	S	Hemimethylated DNA-binding protein YccV like	-	-	-	ko:K11940	-	-	-	-	ko00000,ko03036	-	-	-	YccV-like
k59_509802_2	1322246.BN4_12215	0.000334	42.4	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,42MTF@68525|delta/epsilon subdivisions,2WJ6X@28221|Deltaproteobacteria,2M831@213115|Desulfovibrionales	28221|Deltaproteobacteria	D	PFAM Cobyrinic acid ac-diamide synthase	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_745148_1	674977.VMC_05770	3.09e-07	57.4	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
k59_1515547_1	1158182.KB905020_gene1755	1.19e-98	310.0	COG1205@1|root,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,1S0XD@1236|Gammaproteobacteria,1WXNC@135613|Chromatiales	135613|Chromatiales	L	DEAD DEAH box	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
k59_1150934_1	1121946.AUAX01000019_gene7760	9.12e-79	257.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,2GNCW@201174|Actinobacteria,4DHIQ@85008|Micromonosporales	201174|Actinobacteria	E	FAD dependent oxidoreductase central domain	-	-	1.5.3.19	ko:K19191	ko00760,ko01120,map00760,map01120	-	R10102	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
k59_1623810_1	1304885.AUEY01000016_gene3060	2.91e-48	174.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM penicillin-binding protein, 1A family	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
k59_334318_1	1041146.ATZB01000008_gene2192	1.5e-169	495.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_1742681_2	1121403.AUCV01000013_gene3911	1.61e-08	56.6	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2WJTI@28221|Deltaproteobacteria,2MJ12@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Na Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
k59_1389852_1	1121405.dsmv_1154	1.22e-68	224.0	COG2433@1|root,COG2433@2|Bacteria,1RE5Q@1224|Proteobacteria,42WSA@68525|delta/epsilon subdivisions,2WRPQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_1214611_1	65393.PCC7424_2287	6.8e-98	297.0	COG0337@1|root,COG0337@2|Bacteria,1G2JF@1117|Cyanobacteria,3KH4Z@43988|Cyanothece	1117|Cyanobacteria	H	3-dehydroquinate synthase	-	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_1684854_1	926554.KI912633_gene3985	9.44e-30	124.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1WKH0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EU	PFAM Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_1033945_1	1304275.C41B8_15295	2.15e-70	238.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_1798102_1	1173027.Mic7113_5193	3.79e-08	51.6	COG1669@1|root,COG1669@2|Bacteria,1G6K9@1117|Cyanobacteria,1HCSN@1150|Oscillatoriales	1117|Cyanobacteria	S	Nucleotidyltransferase domain	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
k59_1798102_3	555779.Dthio_PD3437	2.63e-11	67.0	COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,42MBX@68525|delta/epsilon subdivisions,2WJYG@28221|Deltaproteobacteria,2M807@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM periplasmic solute binding protein	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
k59_1281379_2	1049564.TevJSym_bq00030	9.25e-18	82.4	COG1385@1|root,COG4660@1|root,COG1385@2|Bacteria,COG4660@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,1J5UQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
k59_216479_1	1120919.AUBI01000016_gene3580	2.99e-26	110.0	COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,2TS9N@28211|Alphaproteobacteria,2JPH2@204441|Rhodospirillales	204441|Rhodospirillales	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_627116_1	857087.Metme_0378	9.21e-12	65.5	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1S8WW@1236|Gammaproteobacteria,1XEZJ@135618|Methylococcales	135618|Methylococcales	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_627116_2	391615.ABSJ01000050_gene1234	2.09e-76	243.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RN3S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_1214629_1	555778.Hneap_0900	1.73e-33	120.0	COG3223@1|root,COG3223@2|Bacteria,1N0MS@1224|Proteobacteria,1T0QU@1236|Gammaproteobacteria,1WYPM@135613|Chromatiales	135613|Chromatiales	S	PFAM Phosphate-starvation-inducible E	-	-	-	ko:K13256	-	-	-	-	ko00000	-	-	-	PsiE
k59_1515587_2	614083.AWQR01000014_gene2460	9.47e-37	141.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VGZD@28216|Betaproteobacteria,4A9JW@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	ko:K20035	ko00920,map00920	-	R11130	RC03363	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_509853_1	935567.JAES01000014_gene1576	1.02e-06	51.2	COG3147@1|root,COG3147@2|Bacteria,1NGE3@1224|Proteobacteria,1SH3N@1236|Gammaproteobacteria,1X4NY@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
k59_509853_2	857087.Metme_0610	5.86e-08	55.1	COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria,1XFN7@135618|Methylococcales	135618|Methylococcales	S	PFAM Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
k59_1389871_1	1307761.L21SP2_3245	1.4e-100	322.0	COG3250@1|root,COG3250@2|Bacteria,2J5N4@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 2 family	lacZ	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_686521_1	1454010.JEOE01000002_gene479	2.15e-117	345.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4F0UZ@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_216495_2	1209984.BN978_04817	2.16e-92	292.0	COG3500@1|root,COG3500@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K06905	-	-	-	-	ko00000	-	-	-	Phage_GPD
k59_1742724_1	1266925.JHVX01000002_gene781	1.77e-47	168.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VJEM@28216|Betaproteobacteria,372NW@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_1798127_1	717785.HYPMC_1069	8.87e-63	199.0	COG3816@1|root,COG3816@2|Bacteria,1RD5Q@1224|Proteobacteria,2U7DA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein conserved in bacteria	MA20_44640	-	-	ko:K09986	-	-	-	-	ko00000	-	-	-	DUF1285
k59_1281415_2	323848.Nmul_A1524	6.17e-98	292.0	COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,2VQ9I@28216|Betaproteobacteria,371PA@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_796558_1	96561.Dole_1524	7.14e-96	290.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42N7U@68525|delta/epsilon subdivisions,2WJ81@28221|Deltaproteobacteria,2MI27@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_158299_1	991905.SL003B_0575	2.22e-23	97.1	COG0007@1|root,COG0007@2|Bacteria,1MUI0@1224|Proteobacteria,2TRJC@28211|Alphaproteobacteria,4BRWM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	nirE	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
k59_158299_2	1245469.S58_68210	5.9e-24	99.8	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,2U2TJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	nitrite reductase	nirS	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_1798139_1	1123258.AQXZ01000012_gene2213	1.58e-27	115.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4FVIP@85025|Nocardiaceae	201174|Actinobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_509892_2	935839.JAGJ01000033_gene136	6.05e-67	211.0	COG1716@1|root,COG1716@2|Bacteria,2GNZW@201174|Actinobacteria,4F40C@85017|Promicromonosporaceae	201174|Actinobacteria	T	ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_334389_1	1288484.APCS01000107_gene1109	2.55e-70	224.0	COG0444@1|root,COG0444@2|Bacteria,1WJ07@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATP-binding protein, C-terminal domain	appD	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_692624_1	426114.THI_3303	3.11e-49	167.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2VJBW@28216|Betaproteobacteria,1KKE4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_751851_1	408672.NBCG_01027	5.05e-11	68.2	COG1165@1|root,COG1165@2|Bacteria,2GMEB@201174|Actinobacteria,4DPUU@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
k59_633173_1	1121413.JMKT01000010_gene855	2.71e-45	162.0	COG0189@1|root,COG0189@2|Bacteria,1R94D@1224|Proteobacteria,42QKY@68525|delta/epsilon subdivisions,2WJV7@28221|Deltaproteobacteria,2M9N5@213115|Desulfovibrionales	28221|Deltaproteobacteria	HJ	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
k59_1749506_1	631362.Thi970DRAFT_03095	1.24e-31	118.0	28T0P@1|root,2ZF9Z@2|Bacteria,1RAUV@1224|Proteobacteria,1S23D@1236|Gammaproteobacteria,1WY26@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_801821_2	745310.G432_00540	8.25e-54	177.0	COG1028@1|root,COG1028@2|Bacteria,1MVQW@1224|Proteobacteria,2U3DC@28211|Alphaproteobacteria,2KCPB@204457|Sphingomonadales	204457|Sphingomonadales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1524932_1	1077144.AGFF01000012_gene2572	1.33e-09	63.2	COG1933@1|root,COG1933@2|Bacteria,2GTA2@201174|Actinobacteria	201174|Actinobacteria	L	exodeoxyribonuclease I activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_633850_1	1318628.MARLIPOL_16859	8.48e-46	160.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RR6H@1236|Gammaproteobacteria,4664Z@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_633850_2	1120956.JHZK01000019_gene2505	1.36e-55	189.0	COG0702@1|root,COG0702@2|Bacteria,1PT91@1224|Proteobacteria,2U4IU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
k59_693431_1	228410.NE0371	1.95e-32	123.0	COG0584@1|root,COG0584@2|Bacteria,1Q5EZ@1224|Proteobacteria,2WB5D@28216|Betaproteobacteria,372C7@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_223853_1	765912.Thimo_0103	3.95e-173	508.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WVYX@135613|Chromatiales	135613|Chromatiales	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_165744_1	1463900.JOIX01000099_gene7757	9.4e-48	167.0	COG1316@1|root,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria	201174|Actinobacteria	K	cell envelope-related transcriptional attenuator	yvhJ	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
k59_752731_1	887898.HMPREF0551_1758	6.37e-77	241.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2VIM2@28216|Betaproteobacteria,1K3UZ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_223863_1	1123065.ATWL01000014_gene3492	1.98e-101	308.0	COG1109@1|root,COG1109@2|Bacteria,2GJQA@201174|Actinobacteria	201174|Actinobacteria	G	the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells	manB	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1042631_3	2340.JV46_10220	1.26e-33	123.0	2BW2S@1|root,32QYV@2|Bacteria,1RI5M@1224|Proteobacteria,1S614@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1042631_4	1454004.AW11_02478	5.71e-14	67.0	2EE2B@1|root,337X1@2|Bacteria,1N433@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1290879_1	1278078.G419_05597	1.67e-34	130.0	COG0507@1|root,COG3410@1|root,COG0507@2|Bacteria,COG3410@2|Bacteria,2HNSJ@201174|Actinobacteria,4FWM8@85025|Nocardiaceae	201174|Actinobacteria	L	Uncharacterized conserved protein (DUF2075)	-	-	-	ko:K09384	-	-	-	-	ko00000	-	-	-	DUF2075
k59_574777_1	134676.ACPL_7541	8.12e-68	213.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4D9TH@85008|Micromonosporales	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoP	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_870039_1	522373.Smlt3174	5.07e-130	380.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1X2XI@135614|Xanthomonadales	135614|Xanthomonadales	I	acyl-CoA dehydrogenase	acdA	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1042633_1	931626.Awo_c29660	1.52e-33	128.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,25VAD@186806|Eubacteriaceae	186801|Clostridia	E	Psort location Cytoplasmic, score	-	-	2.6.1.1,2.6.1.2,2.6.1.66	ko:K00812,ko:K14260	ko00220,ko00250,ko00270,ko00290,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00258,R00355,R00694,R00734,R00896,R01215,R02433,R02619,R05052	RC00006,RC00008,RC00036	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2,HTH_3
k59_1042633_2	1121022.ABENE_03240	6.72e-22	93.2	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2TRWY@28211|Alphaproteobacteria,2KF6H@204458|Caulobacterales	204458|Caulobacterales	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
k59_870041_1	765912.Thimo_0055	7.58e-94	290.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1WWEC@135613|Chromatiales	135613|Chromatiales	S	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
k59_1397230_1	205922.Pfl01_2765	8.37e-108	323.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2826 Transposase and inactivated derivatives, IS30 family	insI	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
k59_1042655_1	1333998.M2A_0445	9.49e-81	268.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,4BP91@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1692569_1	768671.ThimaDRAFT_2417	3.39e-97	295.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RS8H@1236|Gammaproteobacteria,1WWVZ@135613|Chromatiales	135613|Chromatiales	C	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_870068_1	1235790.C805_02931	3.41e-49	168.0	COG0618@1|root,COG0618@2|Bacteria,1TSHJ@1239|Firmicutes,249EF@186801|Clostridia,25VX7@186806|Eubacteriaceae	186801|Clostridia	S	3'(2'),5'-bisphosphate nucleotidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1804233_1	926564.KI911649_gene1761	7.58e-167	496.0	COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,2GK8P@201174|Actinobacteria,4F3S7@85017|Promicromonosporaceae	201174|Actinobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,PAS_4,PAS_9,SpoIIE
k59_1157320_1	314278.NB231_17058	1.47e-94	301.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1WXN6@135613|Chromatiales	135613|Chromatiales	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_633902_1	187272.Mlg_2624	8.63e-36	139.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
k59_1290922_1	1121456.ATVA01000015_gene2211	3.44e-109	333.0	COG4191@1|root,COG4191@2|Bacteria,1R7KQ@1224|Proteobacteria,42PAP@68525|delta/epsilon subdivisions,2WITB@28221|Deltaproteobacteria,2M8JR@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,dCache_1
k59_457488_1	706587.Desti_5299	1.28e-71	238.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2MR01@213462|Syntrophobacterales	2|Bacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	parC	GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363	5.99.1.3	ko:K02469,ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_574817_1	1232410.KI421421_gene3541	4.22e-28	108.0	COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,42WGY@68525|delta/epsilon subdivisions,2WS4W@28221|Deltaproteobacteria,43VDK@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	TerB
k59_341642_1	477228.YO5_08563	2.36e-11	64.7	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1Z2A6@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_1222290_1	335543.Sfum_0919	6.23e-60	194.0	COG1148@1|root,COG1148@2|Bacteria,1RB0H@1224|Proteobacteria,42QQV@68525|delta/epsilon subdivisions,2WN7E@28221|Deltaproteobacteria,2MRI3@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
k59_870086_1	1120971.AUCA01000078_gene1866	5.06e-32	123.0	COG4974@1|root,COG4974@2|Bacteria,1TQ3R@1239|Firmicutes,4HD6N@91061|Bacilli,278SR@186823|Alicyclobacillaceae	91061|Bacilli	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1222291_1	1346330.M472_22190	1.16e-23	102.0	COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,4NGAN@976|Bacteroidetes,1IPJ6@117747|Sphingobacteriia	976|Bacteroidetes	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OMP_b-brl,OmpA,TSP_3
k59_1042691_1	84531.JMTZ01000039_gene512	6.82e-72	247.0	COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,1T2I5@1236|Gammaproteobacteria,1X59N@135614|Xanthomonadales	135614|Xanthomonadales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1804255_1	95619.PM1_0204675	3.9e-39	130.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,1S8R8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
k59_1631756_1	1392838.AWNM01000006_gene2445	1.75e-34	139.0	COG1178@1|root,COG1178@2|Bacteria,1R0MN@1224|Proteobacteria,2VK7P@28216|Betaproteobacteria,3T76X@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC-type Fe3 transport system permease component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_1804257_1	489825.LYNGBM3L_21220	5.01e-56	201.0	COG1216@1|root,COG5309@1|root,COG1216@2|Bacteria,COG5309@2|Bacteria,1G2MT@1117|Cyanobacteria,1H8YG@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glycos_transf_2
k59_1457711_1	292415.Tbd_1222	1.54e-18	85.1	COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,2VQEZ@28216|Betaproteobacteria	28216|Betaproteobacteria	EG	of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1457711_2	1123399.AQVE01000035_gene3163	3.28e-37	137.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,461WN@72273|Thiotrichales	72273|Thiotrichales	E	PFAM Aminotransferase class I and II	-	-	2.6.1.17	ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1222310_1	670307.HYPDE_30423	2.56e-82	258.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,2TR89@28211|Alphaproteobacteria,3N64S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_1397301_1	439235.Dalk_1445	6.47e-82	271.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MHZ6@213118|Desulfobacterales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1804265_1	1121935.AQXX01000098_gene1664	1.28e-72	231.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1XNPS@135619|Oceanospirillales	135619|Oceanospirillales	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_341673_1	68260.JOAY01000026_gene4310	3.13e-08	60.5	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1804267_1	367299.JOEE01000008_gene587	4.05e-25	103.0	COG0274@1|root,COG0274@2|Bacteria,2GUM7@201174|Actinobacteria,4FETF@85021|Intrasporangiaceae	201174|Actinobacteria	F	Lysine 2,3-aminomutase	-	-	5.4.3.3	ko:K01844	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	Lys-AminoMut_A
k59_1804267_2	1193181.BN10_560034	2.23e-75	233.0	COG2185@1|root,COG2185@2|Bacteria,2HF50@201174|Actinobacteria,4FFS0@85021|Intrasporangiaceae	201174|Actinobacteria	I	Lysine 5,6-aminomutase subunit beta	kamE	-	5.4.3.3	ko:K18011	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	B12-binding,OAM_dimer
k59_870131_1	202955.BBND01000004_gene120	6.75e-27	112.0	COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,1RP5M@1236|Gammaproteobacteria,3NK44@468|Moraxellaceae	1236|Gammaproteobacteria	V	MatE	norM	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
k59_752838_1	72019.SARC_00419T0	9.76e-24	99.8	COG0830@1|root,2REVQ@2759|Eukaryota	2759|Eukaryota	O	nickel cation binding	UREF	GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019627,GO:0034641,GO:0043085,GO:0043603,GO:0044093,GO:0044237,GO:0044281,GO:0050790,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071704,GO:0071941,GO:1901564,GO:1905181,GO:1905182	-	ko:K03188,ko:K16453	-	-	-	-	ko00000,ko03036	-	-	-	UreF
k59_752838_2	1173027.Mic7113_2771	4.88e-18	82.8	COG0804@1|root,COG0804@2|Bacteria,1G12D@1117|Cyanobacteria,1H6ZH@1150|Oscillatoriales	1117|Cyanobacteria	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
k59_1457730_1	1415778.JQMM01000001_gene1253	5.36e-45	168.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1J4HR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the peptidase S16 family	ycbZ	-	-	ko:K04770	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C
k59_1042730_1	396588.Tgr7_0723	6.88e-45	157.0	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,1S02U@1236|Gammaproteobacteria,1WX9F@135613|Chromatiales	135613|Chromatiales	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
k59_1290970_1	2340.JV46_21310	1.54e-31	117.0	2CDCV@1|root,308Y1@2|Bacteria,1N74F@1224|Proteobacteria,1SFME@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_870136_2	76114.ebA3747	5.17e-36	130.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,2VH8U@28216|Betaproteobacteria,2KUZK@206389|Rhodocyclales	206389|Rhodocyclales	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
k59_1573648_1	710421.Mycch_3095	1.51e-67	222.0	COG1541@1|root,COG1541@2|Bacteria,2HQVJ@201174|Actinobacteria,23A9G@1762|Mycobacteriaceae	201174|Actinobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
k59_1457735_2	314266.SKA58_11418	1.34e-52	181.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2K9KC@204457|Sphingomonadales	204457|Sphingomonadales	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_1397320_1	566466.NOR53_2438	2.76e-58	195.0	COG3659@1|root,COG3659@2|Bacteria,1R8TI@1224|Proteobacteria,1S21B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Carbohydrate-selective porin OprB	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB
k59_1397320_2	1033734.CAET01000024_gene1238	2.05e-19	92.0	COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,4H9WQ@91061|Bacilli,1ZAR7@1386|Bacillus	91061|Bacilli	E	COG1473 Metal-dependent amidase aminoacylase carboxypeptidase	yhaA1	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_801949_1	1215092.PA6_016_00240	1.43e-73	230.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1YE83@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048	Formyl_trans_C,Formyl_trans_N
k59_1157366_2	1713.JOFV01000013_gene1000	2.65e-29	119.0	COG4544@1|root,COG4544@2|Bacteria,2IIXE@201174|Actinobacteria,4F1BP@85016|Cellulomonadaceae	201174|Actinobacteria	S	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division	-	GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	-	-	-	-	-	-	-	-	-	-
k59_1290977_1	633131.TR2A62_1421	9.35e-70	231.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0471 Di- and tricarboxylate transporters	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_574875_1	399739.Pmen_2011	1.43e-32	123.0	COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,1RXUZ@1236|Gammaproteobacteria,1YG50@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	F	Glutamine amidotransferase	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
k59_223986_1	639282.DEFDS_0769	1.84e-86	270.0	COG0146@1|root,COG0146@2|Bacteria,2GGAB@200930|Deferribacteres	200930|Deferribacteres	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_165881_1	583355.Caka_1383	4.46e-44	160.0	COG0651@1|root,COG0651@2|Bacteria,46ZH8@74201|Verrucomicrobia,3K7SI@414999|Opitutae	414999|Opitutae	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_1157374_1	472759.Nhal_0131	1.25e-111	360.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RQ0G@1236|Gammaproteobacteria,1WXEX@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1749657_1	1502770.JQMG01000001_gene1494	2.14e-83	252.0	COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,2VRSR@28216|Betaproteobacteria,2KN0E@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Predicted membrane protein (DUF2238)	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
k59_515915_1	580332.Slit_1861	9e-93	296.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,44VAG@713636|Nitrosomonadales	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, N-terminal domain	fadE	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_1042757_1	1109445.AGSX01000048_gene3519	9.65e-191	548.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1Z1M5@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	iEcSMS35_1347.EcSMS35_0456,iJN746.PP_0527	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_1458806_4	446466.Cfla_0841	5.87e-23	90.9	COG2261@1|root,COG2261@2|Bacteria	2|Bacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
k59_762957_1	396588.Tgr7_2173	1.21e-94	290.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1WW79@135613|Chromatiales	135613|Chromatiales	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
k59_1813372_1	1453496.AT03_04800	2.47e-114	355.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008301,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0030983,GO:0031323,GO:0032136,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	iECW_1372.ECW_m2935,iWFL_1372.ECW_m2935	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_583122_1	316057.RPD_1358	2.52e-05	50.8	COG0664@1|root,COG0664@2|Bacteria,1QU34@1224|Proteobacteria,2TVH6@28211|Alphaproteobacteria,3K6UC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Ion transport protein	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,Ion_trans_2,cNMP_binding
k59_583122_3	1340493.JNIF01000003_gene4268	1.3e-21	92.4	COG3193@1|root,COG3193@2|Bacteria,3Y851@57723|Acidobacteria	57723|Acidobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
k59_467293_1	1415779.JOMH01000001_gene2456	6.09e-67	211.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,1X4CF@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes a key regulatory step in fatty acid biosynthesis	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_467300_1	864069.MicloDRAFT_00048180	4.45e-17	78.2	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2TRXP@28211|Alphaproteobacteria,1JS10@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_467300_2	717785.HYPMC_2585	1.06e-17	78.2	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2U592@28211|Alphaproteobacteria,3N6WR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_1466137_1	1121904.ARBP01000006_gene3862	2.63e-86	260.0	COG2133@1|root,COG2133@2|Bacteria,4NK4E@976|Bacteroidetes,47K5J@768503|Cytophagia	976|Bacteroidetes	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
k59_523303_1	643562.Daes_3082	5.35e-39	146.0	COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2WPR9@28221|Deltaproteobacteria,2M7TV@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM Metal-dependent hydrolase HDOD	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
k59_467312_1	1342302.JASC01000014_gene2380	6.7e-102	321.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,3ZW23@60136|Sulfitobacter	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	iorB	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_1813422_1	1121861.KB899911_gene1195	6.21e-129	384.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSTW@28211|Alphaproteobacteria,2JPPG@204441|Rhodospirillales	204441|Rhodospirillales	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1167543_1	1123059.KB823012_gene2248	1.96e-39	140.0	COG5403@1|root,COG5403@2|Bacteria,1N0H4@1224|Proteobacteria,2UFMN@28211|Alphaproteobacteria,43XNE@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
k59_762997_2	335543.Sfum_1330	1.01e-32	124.0	COG2006@1|root,COG2006@2|Bacteria,1QMGX@1224|Proteobacteria,42PRJ@68525|delta/epsilon subdivisions,2WMFN@28221|Deltaproteobacteria,2MQHV@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
k59_702725_1	717773.Thicy_1027	1.85e-40	142.0	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,1S3MU@1236|Gammaproteobacteria,461RE@72273|Thiotrichales	72273|Thiotrichales	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
k59_702725_2	595494.Tola_2716	1.1e-16	74.3	COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,1SCJS@1236|Gammaproteobacteria,1Y4X4@135624|Aeromonadales	135624|Aeromonadales	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
k59_351063_1	583345.Mmol_0049	4.12e-93	292.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,2KKSN@206350|Nitrosomonadales	206350|Nitrosomonadales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
k59_467333_1	857087.Metme_4580	5.8e-15	72.4	COG2227@1|root,COG2227@2|Bacteria,1RE7I@1224|Proteobacteria,1S6PD@1236|Gammaproteobacteria,1XFCI@135618|Methylococcales	135618|Methylococcales	H	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,TehB
k59_467333_2	631362.Thi970DRAFT_02288	2.16e-38	144.0	COG4146@1|root,COG4146@2|Bacteria,1MXWV@1224|Proteobacteria,1RR4S@1236|Gammaproteobacteria,1X0HX@135613|Chromatiales	135613|Chromatiales	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_1583617_1	1123368.AUIS01000001_gene2034	2.98e-117	341.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria,2NBQB@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_1232706_1	999541.bgla_2g14510	7.74e-92	273.0	COG3485@1|root,COG3485@2|Bacteria,1MUYX@1224|Proteobacteria,2VHSS@28216|Betaproteobacteria,1K4IQ@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	protocatechuate 3,4-dioxygenase beta subunit	pcaH	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C,PCDO_beta_N
k59_642425_2	1346791.M529_01910	4.53e-13	78.2	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2U23T@28211|Alphaproteobacteria,2K01Z@204457|Sphingomonadales	204457|Sphingomonadales	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
k59_1758166_1	1217718.ALOU01000007_gene1227	5.94e-18	85.1	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria	28216|Betaproteobacteria	M	surface antigen variable number repeat protein	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k59_1758166_2	1121875.KB907547_gene2995	1.48e-10	64.3	COG2067@1|root,COG2067@2|Bacteria,4NX18@976|Bacteroidetes,1I5D9@117743|Flavobacteriia	976|Bacteroidetes	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1055709_1	1283299.AUKG01000001_gene3420	1.1e-119	370.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4CQYD@84995|Rubrobacteria	84995|Rubrobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	-	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_351087_2	1144343.PMI41_03819	3.88e-39	142.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2TSJY@28211|Alphaproteobacteria,43IGK@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_351094_1	1502724.FF80_03107	1.19e-113	335.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2TS7B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_1758177_1	1202962.KB907152_gene1109	2.33e-85	281.0	COG0247@1|root,COG0277@1|root,COG0479@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG0479@2|Bacteria,1MU6Y@1224|Proteobacteria,1RM7Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S ferredoxin	lldE	-	-	ko:K18930	-	-	-	-	ko00000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_7,Fer4_8
k59_175951_1	177437.HRM2_31420	2.5e-83	260.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria,2MIIZ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_809935_1	870187.Thini_4353	6.37e-59	196.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,460BB@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
k59_1055728_1	314285.KT71_17806	1.96e-86	269.0	COG0531@1|root,COG0531@2|Bacteria,1QXK2@1224|Proteobacteria,1TH39@1236|Gammaproteobacteria,1J4VH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	amino acid polyamine organocation transporter, APC superfamily (TC 2.A.3)	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_583176_1	1144310.PMI07_003466	7.97e-09	61.6	28MWZ@1|root,2ZB46@2|Bacteria,1R7K6@1224|Proteobacteria,2U4ZP@28211|Alphaproteobacteria,4BIFC@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1167630_1	35754.JNYJ01000020_gene298	1.05e-08	53.9	COG1051@1|root,COG1051@2|Bacteria,2GT4E@201174|Actinobacteria,4DG0C@85008|Micromonosporales	201174|Actinobacteria	F	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
k59_1167630_2	596151.DesfrDRAFT_2105	1.03e-39	150.0	COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,1RCHY@1224|Proteobacteria,42R1G@68525|delta/epsilon subdivisions,2WMR7@28221|Deltaproteobacteria,2M83U@213115|Desulfovibrionales	28221|Deltaproteobacteria	KT	SMART protein phosphatase 2C domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE
k59_1167633_2	321327.CYA_2679	1.06e-60	197.0	COG1087@1|root,COG1087@2|Bacteria,1G08G@1117|Cyanobacteria,1GYW5@1129|Synechococcus	1117|Cyanobacteria	M	UDP-glucose 4-epimerase	galE	-	5.1.3.2,5.1.3.5	ko:K01784,ko:K12448	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R01473,R02984	RC00289,RC00528	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_702780_1	498211.CJA_0452	2.41e-51	175.0	COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria,1FGH0@10|Cellvibrio	1236|Gammaproteobacteria	L	DNA polymerase III, delta subunit	holA	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delt_C,DNA_pol3_delta
k59_702780_2	472759.Nhal_2251	6.75e-101	301.0	COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,1RMYN@1236|Gammaproteobacteria,1X0DE@135613|Chromatiales	135613|Chromatiales	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_467413_1	318167.Sfri_2288	3.25e-44	157.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,1T20X@1236|Gammaproteobacteria,2QAVG@267890|Shewanellaceae	1236|Gammaproteobacteria	C	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
k59_467413_2	1198232.CYCME_1782	1.69e-45	162.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,463IR@72273|Thiotrichales	72273|Thiotrichales	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_1055761_1	56780.SYN_02917	3.85e-114	340.0	COG2509@1|root,COG2509@2|Bacteria,1MV6P@1224|Proteobacteria,42N2K@68525|delta/epsilon subdivisions,2WJ5D@28221|Deltaproteobacteria,2MR6D@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	FAD binding domain	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	DAO,FAD_binding_2,GIDA,HI0933_like,Pyr_redox_2
k59_1758204_1	96561.Dole_0237	1.15e-107	341.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,42MYQ@68525|delta/epsilon subdivisions,2WJM2@28221|Deltaproteobacteria,2MIQM@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA polymerase III alpha subunit	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_233810_2	1298593.TOL_2459	1.14e-68	221.0	COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,1RREE@1236|Gammaproteobacteria,1XKAP@135619|Oceanospirillales	135619|Oceanospirillales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_175984_1	187272.Mlg_2494	6.43e-21	89.4	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,1WX5V@135613|Chromatiales	135613|Chromatiales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
k59_175984_2	396588.Tgr7_2234	2.34e-85	261.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1WWB3@135613|Chromatiales	135613|Chromatiales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_583200_1	661367.LLO_0453	2.31e-18	84.3	COG1926@1|root,COG1926@2|Bacteria,1RAG8@1224|Proteobacteria,1S3SH@1236|Gammaproteobacteria,1JD8H@118969|Legionellales	118969|Legionellales	F	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
k59_1167670_1	1121937.AUHJ01000004_gene1171	2.21e-52	170.0	COG2259@1|root,COG2259@2|Bacteria,1RDYW@1224|Proteobacteria,1S3RT@1236|Gammaproteobacteria,466ZI@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	TQO small subunit DoxD	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
k59_585110_1	713586.KB900536_gene2868	2.06e-134	394.0	COG0312@1|root,COG0312@2|Bacteria,1QM7I@1224|Proteobacteria,1RSF3@1236|Gammaproteobacteria,1WWFH@135613|Chromatiales	135613|Chromatiales	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
k59_525733_1	1267005.KB911256_gene1475	1.35e-104	318.0	COG1075@1|root,COG1075@2|Bacteria,1NMH0@1224|Proteobacteria,2TXVV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function(DUF2779)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2779
k59_1408787_1	1292034.OR37_02731	4.83e-79	255.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2KFVS@204458|Caulobacterales	204458|Caulobacterales	S	Sulfotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_14,TPR_16,TPR_19,TPR_8
k59_811892_1	1122915.AUGY01000001_gene6976	1.68e-05	53.9	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HBZ0@91061|Bacilli,26R4M@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	resE	-	2.7.13.3	ko:K07651	ko02020,map02020	M00458	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
k59_585126_1	994573.T472_0211705	5.14e-34	130.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,36G29@31979|Clostridiaceae	186801|Clostridia	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_525759_1	1123368.AUIS01000007_gene2681	1.2e-72	241.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,2NCDM@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Belongs to the UPF0753 family	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k59_1642772_1	472759.Nhal_3802	2.27e-57	209.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1WXCY@135613|Chromatiales	135613|Chromatiales	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_644893_1	1121423.JONT01000017_gene118	1.57e-81	268.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,260NC@186807|Peptococcaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_644912_1	717785.HYPMC_0554	1.68e-31	127.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,3N6E3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the helicase family. UvrD subfamily	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1408820_1	395494.Galf_0330	3.82e-73	237.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2VH2H@28216|Betaproteobacteria,44VA0@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10,6.3.2.13	ko:K01929,ko:K15792	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R02788,R04573,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1408820_2	1111479.AXAR01000017_gene2729	2.73e-09	58.5	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,4H9T1@91061|Bacilli,2782R@186823|Alicyclobacillaceae	91061|Bacilli	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_525801_1	1032480.MLP_23740	1.81e-77	237.0	COG0537@1|root,COG0537@2|Bacteria,2GJT5@201174|Actinobacteria,4DQ7R@85009|Propionibacteriales	201174|Actinobacteria	FG	HIT domain	-	GO:0003674,GO:0003824,GO:0003877,GO:0004551,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008796,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0015959,GO:0015961,GO:0015965,GO:0015967,GO:0016020,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070566,GO:0071704,GO:0071944,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
k59_1760425_1	1255043.TVNIR_1950	8.15e-81	251.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1WXDH@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_1170945_1	1121933.AUHH01000009_gene790	2.03e-29	118.0	COG0433@1|root,COG0433@2|Bacteria,2IQZ3@201174|Actinobacteria	201174|Actinobacteria	T	COG0433 Predicted ATPase	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
k59_1816644_2	313606.M23134_08087	1.65e-13	69.3	COG1944@1|root,COG1944@2|Bacteria,4NKRG@976|Bacteroidetes	976|Bacteroidetes	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
k59_1760441_1	314345.SPV1_12707	7.15e-96	285.0	COG0778@1|root,COG0778@2|Bacteria,1PG8V@1224|Proteobacteria	1224|Proteobacteria	C	Nitroreductase	pnbA	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_811952_1	266264.Rmet_5349	1.23e-46	165.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2VHQS@28216|Betaproteobacteria,1K2N3@119060|Burkholderiaceae	28216|Betaproteobacteria	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K06714	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,PAS_4,Sigma54_activat
k59_1170970_1	243231.GSU1048	9.12e-40	137.0	COG3012@1|root,COG3012@2|Bacteria,1MZZK@1224|Proteobacteria,42RE5@68525|delta/epsilon subdivisions,2WNNI@28221|Deltaproteobacteria,43V2V@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	SEC-C motif	-	-	-	ko:K09858	-	-	-	-	ko00000	-	-	-	SEC-C
k59_645001_2	883126.HMPREF9710_04162	3.96e-48	160.0	COG1136@1|root,COG1136@2|Bacteria,1NCFC@1224|Proteobacteria,2VIQD@28216|Betaproteobacteria,4735R@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_811989_1	765910.MARPU_06910	5.25e-45	162.0	COG0398@1|root,COG1502@1|root,COG0398@2|Bacteria,COG1502@2|Bacteria,1MV8I@1224|Proteobacteria,1RSB6@1236|Gammaproteobacteria,1WXPA@135613|Chromatiales	135613|Chromatiales	I	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	PLDc,PLDc_2,SNARE_assoc
k59_811992_1	156889.Mmc1_2324	1.12e-17	82.4	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,2TT3P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Acyl-transferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_811992_2	572477.Alvin_3004	1.75e-32	119.0	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,1S3UD@1236|Gammaproteobacteria,1WY8W@135613|Chromatiales	135613|Chromatiales	E	D,D-heptose 1,7-bisphosphate phosphatase	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
k59_585268_1	367299.JOEE01000008_gene515	4.04e-19	85.9	COG2334@1|root,COG2334@2|Bacteria,2GXZI@201174|Actinobacteria,4FF5T@85021|Intrasporangiaceae	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_585268_2	1380356.JNIK01000017_gene3077	2.03e-23	100.0	COG1506@1|root,COG1506@2|Bacteria,2GNG5@201174|Actinobacteria,4ES4B@85013|Frankiales	201174|Actinobacteria	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_811993_1	338963.Pcar_1385	2.63e-76	238.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,43TYM@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_525885_1	768671.ThimaDRAFT_3015	7.18e-45	162.0	2C69V@1|root,2Z9DY@2|Bacteria,1R5H6@1224|Proteobacteria,1RZY0@1236|Gammaproteobacteria,1WXUP@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1816696_1	246197.MXAN_1758	1.82e-115	339.0	COG1063@1|root,COG1063@2|Bacteria,1MW6Y@1224|Proteobacteria	1224|Proteobacteria	E	Dehydrogenase	-	-	1.1.1.14,1.1.1.303,1.1.1.4	ko:K00004,ko:K00008	ko00040,ko00051,ko00650,ko01100,map00040,map00051,map00650,map01100	M00014	R00875,R01896,R02855,R02946,R10504	RC00085,RC00102,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
k59_525887_1	1095767.CAHD01000115_gene57	2.19e-84	273.0	COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria,4F0KV@85016|Cellulomonadaceae	201174|Actinobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_525899_1	56780.SYN_02374	4.02e-95	303.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2WJ3E@28221|Deltaproteobacteria,2MQ60@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	TIGRFAM leucyl-tRNA synthetase	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_2300	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_645035_1	883126.HMPREF9710_00160	1.08e-13	74.7	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2W0VY@28216|Betaproteobacteria	1224|Proteobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_645035_2	1121930.AQXG01000015_gene1870	5.78e-57	194.0	COG0534@1|root,COG0534@2|Bacteria,4NEBB@976|Bacteroidetes,1IPQM@117747|Sphingobacteriia	976|Bacteroidetes	V	efflux protein, MATE family	norM	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
k59_1408915_1	744980.TRICHSKD4_5308	1.31e-11	62.8	COG0461@1|root,COG0461@2|Bacteria,1RIC5@1224|Proteobacteria,2TUX2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
k59_416290_1	1265313.HRUBRA_01495	3.03e-63	205.0	COG1597@1|root,COG1597@2|Bacteria,1RIZ6@1224|Proteobacteria,1S4KN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
k59_475201_1	590998.Celf_2653	1.35e-11	66.6	COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria,4F0GT@85016|Cellulomonadaceae	201174|Actinobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_475201_2	1304865.JAGF01000001_gene2687	1.86e-47	163.0	28JAE@1|root,2Z957@2|Bacteria,2IFSW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_1414651_1	1392502.JNIO01000008_gene1836	3.7e-52	176.0	COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,4H2M2@909932|Negativicutes	909932|Negativicutes	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_1415417_1	1304865.JAGF01000001_gene2439	2.59e-90	278.0	COG0479@1|root,COG0479@2|Bacteria,2I37A@201174|Actinobacteria	201174|Actinobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
k59_243215_1	1208323.B30_05822	6.74e-118	340.0	COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,2TTE6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	scoA	-	2.8.3.5	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_827902_2	768671.ThimaDRAFT_2048	4.23e-88	266.0	COG4313@1|root,COG4313@2|Bacteria,1ND6Y@1224|Proteobacteria,1RYD3@1236|Gammaproteobacteria,1WW33@135613|Chromatiales	135613|Chromatiales	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
k59_1300960_1	1027273.GZ77_20855	4.72e-156	462.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1XHNC@135619|Oceanospirillales	135619|Oceanospirillales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_9423_1	1031711.RSPO_c02760	1.07e-11	67.0	COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,2VJ44@28216|Betaproteobacteria,1K0NB@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	pqiB	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_9423_2	338966.Ppro_0404	4.53e-23	99.0	COG3009@1|root,COG3009@2|Bacteria,1N8BW@1224|Proteobacteria,42UW2@68525|delta/epsilon subdivisions,2WQFD@28221|Deltaproteobacteria,43VBT@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K09857	-	-	-	-	ko00000	-	-	-	ABC_trans_aux
k59_9423_3	1198232.CYCME_1793	9.21e-14	69.3	COG0680@1|root,COG0680@2|Bacteria,1MZE1@1224|Proteobacteria,1SB0K@1236|Gammaproteobacteria,4630Z@72273|Thiotrichales	72273|Thiotrichales	C	hydrogenase maturation protease	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_710726_1	595536.ADVE02000001_gene406	5e-14	70.9	COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,2TQTX@28211|Alphaproteobacteria,36X89@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Inositol monophosphatase family	hisN	-	3.1.3.15,3.1.3.25,3.1.3.93	ko:K01092,ko:K18649	ko00053,ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00053,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00114,M00131	R01185,R01186,R01187,R03013,R07674	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_710726_2	1449065.JMLL01000001_gene4044	1.48e-26	108.0	COG2267@1|root,COG2267@2|Bacteria,1MWDA@1224|Proteobacteria,2TSZ4@28211|Alphaproteobacteria,43HRC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	pldB	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
k59_9425_1	568706.BN118_1764	1.63e-66	212.0	COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,2VJCQ@28216|Betaproteobacteria,3T5UU@506|Alcaligenaceae	28216|Betaproteobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
k59_768484_1	247639.MGP2080_08866	1.4e-50	172.0	COG2066@1|root,COG2066@2|Bacteria,1MWB5@1224|Proteobacteria,1RMY9@1236|Gammaproteobacteria,1J9TJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Glutaminase	glsA	GO:0003674,GO:0003824,GO:0004359,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006543,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009084,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016043,GO:0016053,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0022607,GO:0040008,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0045926,GO:0046394,GO:0046395,GO:0048519,GO:0050789,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	e_coli_core.b0485,iAF1260.b0485,iB21_1397.B21_00441,iBWG_1329.BWG_0366,iECBD_1354.ECBD_3171,iECB_1328.ECB_00436,iECDH10B_1368.ECDH10B_0442,iECDH1ME8569_1439.ECDH1ME8569_0469,iECD_1391.ECD_00436,iECO111_1330.ECO111_0520,iETEC_1333.ETEC_0537,iEcDH1_1363.EcDH1_3125,iJO1366.b0485,iJR904.b0485,iUMNK88_1353.UMNK88_538,iY75_1357.Y75_RS02500	Glutaminase
k59_948784_1	314345.SPV1_10591	8e-113	352.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria	1224|Proteobacteria	P	Heavy metal translocating P-type atpase	copF	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
k59_1829132_1	383372.Rcas_0372	1.58e-118	367.0	COG0474@1|root,COG0474@2|Bacteria,2G5ZS@200795|Chloroflexi,37711@32061|Chloroflexia	32061|Chloroflexia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_1829132_2	1415778.JQMM01000001_gene233	8.12e-39	141.0	COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,1RXUZ@1236|Gammaproteobacteria,1J72J@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Peptidase C26	-	-	-	-	-	-	-	-	-	-	-	-	GATase
k59_9433_1	395493.BegalDRAFT_1564	9.27e-121	374.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,460EP@72273|Thiotrichales	72273|Thiotrichales	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1356385_1	1232437.KL662006_gene4420	8.93e-49	176.0	COG0769@1|root,COG0770@1|root,COG0769@2|Bacteria,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,43BV1@68525|delta/epsilon subdivisions,2X760@28221|Deltaproteobacteria,2MPKR@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.10,6.3.2.13	ko:K15792	ko00300,ko00550,map00300,map00550	-	R02788,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_243268_1	930946.AEOP01000030_gene470	1.02e-05	50.4	COG0775@1|root,COG0775@2|Bacteria,1U7WK@1239|Firmicutes,4HB8K@91061|Bacilli,4AXGS@81850|Leuconostocaceae	91061|Bacilli	E	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	mtnN	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
k59_1532331_1	1248916.ANFY01000010_gene428	3.75e-30	121.0	COG0526@1|root,COG0526@2|Bacteria,1QZTD@1224|Proteobacteria,2UV4I@28211|Alphaproteobacteria,2KB4S@204457|Sphingomonadales	204457|Sphingomonadales	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
k59_243269_1	28152.DJ57_2747	1.16e-69	236.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,41DQX@629|Yersinia	1236|Gammaproteobacteria	F	Carbamoyl-phosphate synthetase ammonia chain	carB	GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019627,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041	CPSase_L_D2,CPSase_L_D3,MGS
k59_9445_1	935863.AWZR01000003_gene2729	1.67e-22	103.0	2E7DT@1|root,331WV@2|Bacteria,1N9K6@1224|Proteobacteria,1T0Q4@1236|Gammaproteobacteria,1X53P@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
k59_1063531_1	706587.Desti_3103	6.7e-11	61.6	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	acyl-coa dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1063531_2	706587.Desti_3102	1.8e-56	181.0	COG1426@1|root,COG1917@1|root,COG1426@2|Bacteria,COG1917@2|Bacteria,1QWMR@1224|Proteobacteria,43BSQ@68525|delta/epsilon subdivisions,2X73G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_31
k59_534723_2	743718.Isova_0604	2.21e-50	176.0	COG1716@1|root,COG1716@2|Bacteria,2IGW5@201174|Actinobacteria,4F3DA@85017|Promicromonosporaceae	201174|Actinobacteria	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
k59_475929_2	42565.FP66_13730	2.08e-63	211.0	COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,1RPGF@1236|Gammaproteobacteria,1XI5B@135619|Oceanospirillales	135619|Oceanospirillales	V	MATE efflux family protein	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
k59_299920_1	525909.Afer_1020	9.53e-152	456.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4CNGZ@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1829143_1	292415.Tbd_2601	0.000516	43.1	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VIIX@28216|Betaproteobacteria	28216|Betaproteobacteria	S	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1829143_2	1123054.KB907703_gene1342	3.64e-84	265.0	COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,1RRGY@1236|Gammaproteobacteria,1WVVW@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
k59_593353_1	1116472.MGMO_83c00160	1.62e-42	152.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1XESH@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
k59_593353_2	396588.Tgr7_1034	7.59e-74	235.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1WWPS@135613|Chromatiales	135613|Chromatiales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_182467_1	1380356.JNIK01000017_gene3043	7.11e-34	132.0	COG1196@1|root,COG1196@2|Bacteria,2GJBD@201174|Actinobacteria,4ES6S@85013|Frankiales	201174|Actinobacteria	D	Domain of Unknown Function (DUF349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF349
k59_534727_1	1247649.D560_3828	1.58e-105	313.0	COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,2VN7F@28216|Betaproteobacteria,3T7ZU@506|Alcaligenaceae	28216|Betaproteobacteria	L	Transposase for IS481 element	-	-	-	-	-	-	-	-	-	-	-	-	LZ_Tnp_IS481,rve,rve_3
k59_652159_1	1693.BMIN_1537	1.93e-41	147.0	COG0330@1|root,COG0330@2|Bacteria,2GM0Z@201174|Actinobacteria,4D1Z1@85004|Bifidobacteriales	201174|Actinobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_652159_2	1380347.JNII01000005_gene3758	1.22e-58	186.0	COG4119@1|root,COG4119@2|Bacteria,2IM6D@201174|Actinobacteria,4ET4C@85013|Frankiales	201174|Actinobacteria	L	PFAM NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_123741_1	243233.MCA0768	6.33e-76	238.0	COG0167@1|root,COG0167@2|Bacteria,1MXER@1224|Proteobacteria,1RRTA@1236|Gammaproteobacteria,1XDK5@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_9464_1	990285.RGCCGE502_23110	1.33e-46	169.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2TQTQ@28211|Alphaproteobacteria,4B8GZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C
k59_948812_2	95619.PM1_0226330	8.36e-63	208.0	COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,1RSQ1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Zn-dependent protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_417013_2	935567.JAES01000011_gene1149	1.22e-13	73.6	COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,1S8S0@1236|Gammaproteobacteria,1X6QG@135614|Xanthomonadales	135614|Xanthomonadales	S	SURF1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	SURF1
k59_475938_2	697282.Mettu_0395	1.22e-06	50.4	COG5520@1|root,COG5520@2|Bacteria,1N9T9@1224|Proteobacteria,1RP92@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 30 family	-	-	3.2.1.45	ko:K01201	ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH30	-	Glyco_hydro_30,Glyco_hydro_30C
k59_948814_1	1286093.C266_21939	1.2e-145	434.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,1KIEV@119060|Burkholderiaceae	28216|Betaproteobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_948817_1	1713.JOFV01000004_gene3453	3.13e-75	238.0	COG0758@1|root,COG0758@2|Bacteria,2GKDA@201174|Actinobacteria,4F0K2@85016|Cellulomonadaceae	201174|Actinobacteria	LU	DNA recombination-mediator protein A	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_9476_1	1288826.MSNKSG1_00551	2.89e-16	73.9	COG0355@1|root,COG0355@2|Bacteria,1N1NE@1224|Proteobacteria,1S9B5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	epsilon subunit	-	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
k59_9476_2	1288826.MSNKSG1_00546	1.34e-41	138.0	2E70X@1|root,331JP@2|Bacteria,1N81S@1224|Proteobacteria,1SCI0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
k59_9476_3	1121403.AUCV01000038_gene4230	5.67e-21	89.0	COG0356@1|root,COG0356@2|Bacteria,1RBEV@1224|Proteobacteria	1224|Proteobacteria	C	it plays a direct role in the translocation of protons across the membrane	-	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1003442_2	1479237.JMLY01000001_gene3661	3.19e-07	53.1	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Response regulator containing a CheY-like receiver domain and an HD-GYP domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
k59_1829169_1	582899.Hden_1700	4.2e-78	245.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2TQUB@28211|Alphaproteobacteria,3N7AB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	permease YjgP YjgQ family protein	MA20_28210	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_1708536_1	1415755.JQLV01000001_gene1306	2.11e-10	67.4	COG1647@1|root,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,1T1TS@1236|Gammaproteobacteria,1XKDI@135619|Oceanospirillales	135619|Oceanospirillales	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
k59_827950_1	335543.Sfum_3923	4.93e-110	339.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,2MRI6@213462|Syntrophobacterales	28221|Deltaproteobacteria	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_827950_3	1121438.JNJA01000004_gene577	9.36e-25	102.0	COG1566@1|root,COG1566@2|Bacteria,1MWG0@1224|Proteobacteria,42NAT@68525|delta/epsilon subdivisions,2WPPB@28221|Deltaproteobacteria,2MBTW@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1590802_1	1049564.TevJSym_br00020	2.78e-36	136.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1590802_2	382464.ABSI01000002_gene4373	3.32e-117	350.0	COG4656@1|root,COG4656@2|Bacteria,46W83@74201|Verrucomicrobia	74201|Verrucomicrobia	C	RnfC Barrel sandwich hybrid domain	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_51K,Fer4_17,RnfC_N,SLBB
k59_948824_1	694431.DESACE_00540	2.53e-28	114.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,42M7Y@68525|delta/epsilon subdivisions,2WIRN@28221|Deltaproteobacteria,2M6G5@213113|Desulfurellales	28221|Deltaproteobacteria	E	Argininosuccinate lyase C-terminal	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1,NUDIX
k59_948824_2	177416.FTT_1150c	3.66e-23	101.0	COG0506@1|root,COG1012@1|root,COG4230@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,1RN48@1236|Gammaproteobacteria,45ZVC@72273|Thiotrichales	72273|Thiotrichales	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	-	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
k59_299938_1	136273.GY22_10760	7.05e-33	124.0	COG1162@1|root,COG1162@2|Bacteria,2GJ37@201174|Actinobacteria,1W86A@1268|Micrococcaceae	201174|Actinobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
k59_299938_2	478801.Ksed_18980	2.16e-48	167.0	COG0128@1|root,COG0128@2|Bacteria,2GJKX@201174|Actinobacteria,1ZVKC@145357|Dermacoccaceae	201174|Actinobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_1474772_1	1410634.JHVD01000014_gene460	1.28e-34	132.0	COG4214@1|root,COG4214@2|Bacteria,2GJAH@201174|Actinobacteria,4DNDK@85009|Propionibacteriales	201174|Actinobacteria	P	Branched-chain amino acid transport system / permease component	araH	-	-	ko:K10544,ko:K10547	ko02010,map02010	M00215,M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4,3.A.1.2.5	-	-	BPD_transp_2
k59_68122_1	570268.ANBB01000014_gene5398	1.76e-18	85.9	COG2252@1|root,COG2252@2|Bacteria,2GKYD@201174|Actinobacteria,4EHE7@85012|Streptosporangiales	201174|Actinobacteria	S	Permease family	pbuG	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
k59_1532359_1	446469.Sked_03960	3.85e-68	227.0	COG2367@1|root,COG2367@2|Bacteria,2GNRZ@201174|Actinobacteria	201174|Actinobacteria	V	Beta-lactamase class A	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase2
k59_1829182_1	768671.ThimaDRAFT_2982	6e-74	229.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,1RPYA@1236|Gammaproteobacteria,1X0WW@135613|Chromatiales	135613|Chromatiales	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
k59_710771_1	498211.CJA_3511	1.29e-57	186.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RQQ3@1236|Gammaproteobacteria,1FGJ2@10|Cellvibrio	1236|Gammaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483,ko:K07666	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1356430_1	1121374.KB891575_gene1014	1.45e-29	112.0	COG0801@1|root,COG0801@2|Bacteria,1RHNN@1224|Proteobacteria,1S62M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK2	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
k59_1356430_2	686340.Metal_3436	3.45e-09	55.1	COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,1S9B2@1236|Gammaproteobacteria,1XFDQ@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
k59_1590810_1	1423321.AS29_07385	9.98e-51	174.0	COG3547@1|root,COG3547@2|Bacteria,1V427@1239|Firmicutes,4HGY6@91061|Bacilli,1ZERT@1386|Bacillus	91061|Bacilli	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_827962_1	1249627.D779_3550	2.89e-62	192.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,1S3Q2@1236|Gammaproteobacteria,1WYDZ@135613|Chromatiales	135613|Chromatiales	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
k59_827962_2	948565.AFFP02000030_gene1189	2.45e-55	175.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,1Y8MZ@135625|Pasteurellales	135625|Pasteurellales	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_593391_1	1713.JOFV01000015_gene1777	1.28e-56	187.0	COG3429@1|root,COG3429@2|Bacteria,2GJ1H@201174|Actinobacteria,4F10N@85016|Cellulomonadaceae	201174|Actinobacteria	G	Glucose-6-phosphate dehydrogenase subunit	opcA	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
k59_768531_1	1307761.L21SP2_2654	1.61e-27	111.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_593393_1	225849.swp_3157	4.43e-18	79.3	COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,1SCRA@1236|Gammaproteobacteria,2QCY0@267890|Shewanellaceae	1236|Gammaproteobacteria	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
k59_541521_1	435830.HMPREF0045_01800	3.92e-09	62.8	COG0489@1|root,COG3944@1|root,COG0489@2|Bacteria,COG3944@2|Bacteria,2GJ1Y@201174|Actinobacteria,4D49G@85005|Actinomycetales	201174|Actinobacteria	D	biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,CbiA,ParA,Wzz
k59_371172_1	1120942.AUBM01000008_gene98	2.72e-07	51.6	COG0223@1|root,COG0223@2|Bacteria,2GKH5@201174|Actinobacteria,4D3S2@85005|Actinomycetales	201174|Actinobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_371172_2	234621.RER_30120	1.88e-05	49.3	COG1198@1|root,COG1198@2|Bacteria,2GKES@201174|Actinobacteria,4FVC4@85025|Nocardiaceae	201174|Actinobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
k59_958452_1	1049564.TevJSym_ad00300	2.05e-10	61.6	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1J90E@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_958452_2	1049564.TevJSym_ad00290	1.66e-68	234.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,1J980@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2309)	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k59_835127_1	398579.Spea_1395	8.12e-90	292.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,1RQSM@1236|Gammaproteobacteria,2Q8WR@267890|Shewanellaceae	1236|Gammaproteobacteria	M	PFAM polysaccharide export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
k59_371183_2	1415166.NONO_c68270	3.64e-10	59.3	COG0207@1|root,COG0207@2|Bacteria,2GKY0@201174|Actinobacteria,4FVPC@85025|Nocardiaceae	201174|Actinobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	GO:0003674,GO:0003824,GO:0004799,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009125,GO:0009129,GO:0009130,GO:0009131,GO:0009157,GO:0009159,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009178,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0032259,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042083,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046073,GO:0046078,GO:0046079,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
k59_423967_1	1194165.CAJF01000012_gene1007	4.54e-05	50.4	COG3595@1|root,COG3595@2|Bacteria,2GWE4@201174|Actinobacteria	201174|Actinobacteria	S	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
k59_423967_2	211114.JOEF01000001_gene7235	1.06e-60	197.0	COG0842@1|root,COG0842@2|Bacteria,2GJ2G@201174|Actinobacteria,4E1IX@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_306479_1	1170562.Cal6303_0911	2.16e-40	152.0	COG0474@1|root,COG0474@2|Bacteria,1G0JX@1117|Cyanobacteria,1HJKB@1161|Nostocales	1117|Cyanobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_131095_1	1120999.JONM01000012_gene2280	5.45e-27	108.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2VH7Y@28216|Betaproteobacteria,2KPTJ@206351|Neisseriales	206351|Neisseriales	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_131095_2	1269813.ATUL01000015_gene130	1.22e-21	91.3	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1WWZU@135613|Chromatiales	135613|Chromatiales	M	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
k59_1363196_1	670307.HYPDE_37758	2.2e-96	301.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2TRBP@28211|Alphaproteobacteria,3N6DR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_717972_1	1122603.ATVI01000009_gene2612	7.39e-08	51.6	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_1773528_1	485918.Cpin_0727	2.8e-82	259.0	COG0554@1|root,COG0554@2|Bacteria,4NFUH@976|Bacteroidetes,1IP31@117747|Sphingobacteriia	976|Bacteroidetes	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_1422782_1	247490.KSU1_C0842	4.59e-58	200.0	COG0308@1|root,COG0308@2|Bacteria	2|Bacteria	E	peptide catabolic process	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_0348	Cofac_haem_bdg,PDZ_2,Peptidase_M1,Peptidase_M28
k59_306486_1	1121468.AUBR01000011_gene2484	1.38e-75	239.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,42F68@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_774204_1	686340.Metal_0091	2.03e-85	270.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1XEQP@135618|Methylococcales	135618|Methylococcales	CI	Conserved carboxylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_1074945_1	1168059.KB899087_gene3017	1.67e-75	238.0	COG0717@1|root,COG0717@2|Bacteria,1MVDH@1224|Proteobacteria,2TR5U@28211|Alphaproteobacteria,3EYPK@335928|Xanthobacteraceae	28211|Alphaproteobacteria	F	2'-deoxycytidine 5'-triphosphate deaminase (DCD)	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
k59_1838843_1	713586.KB900536_gene2939	5.54e-91	293.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1WVV2@135613|Chromatiales	135613|Chromatiales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_717979_1	765911.Thivi_4593	2.13e-49	176.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1WW15@135613|Chromatiales	135613|Chromatiales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_599805_1	768671.ThimaDRAFT_4608	2.52e-12	67.8	COG4322@1|root,COG4322@2|Bacteria,1R4WQ@1224|Proteobacteria,1SZ11@1236|Gammaproteobacteria,1WX5W@135613|Chromatiales	135613|Chromatiales	S	Uncharacterized protein conserved in bacteria (DUF2272)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2272
k59_599805_2	768671.ThimaDRAFT_4609	1.61e-50	176.0	COG0674@1|root,COG0674@2|Bacteria,1QVAZ@1224|Proteobacteria,1S0VA@1236|Gammaproteobacteria,1WVZZ@135613|Chromatiales	135613|Chromatiales	C	pyruvate-flavodoxin oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_899486_2	570967.JMLV01000001_gene2771	1.37e-41	148.0	COG3660@1|root,COG3660@2|Bacteria,1R70U@1224|Proteobacteria,2TQWV@28211|Alphaproteobacteria,2JTHZ@204441|Rhodospirillales	204441|Rhodospirillales	M	Mitochondrial fission ELM1	-	-	-	ko:K07276	-	-	-	-	ko00000	-	-	-	Mito_fiss_Elm1
k59_1187829_1	187272.Mlg_2231	1.47e-45	149.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,1WYWY@135613|Chromatiales	135613|Chromatiales	J	Sigma 54 modulation protein	-	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
k59_1187829_2	314278.NB231_05781	1.57e-48	160.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,1S668@1236|Gammaproteobacteria,1WYAA@135613|Chromatiales	135613|Chromatiales	G	PTS IIA-like nitrogen-regulatory protein PtsN	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
k59_1126735_1	1249627.D779_2249	3.71e-68	214.0	COG1179@1|root,COG1179@2|Bacteria,1MWXR@1224|Proteobacteria,1RMT3@1236|Gammaproteobacteria,1WXXZ@135613|Chromatiales	135613|Chromatiales	H	PFAM UBA THIF-type NAD FAD binding	-	-	-	ko:K22132	-	-	-	-	ko00000,ko03016	-	-	-	ThiF
k59_1126735_2	195250.CM001776_gene1271	2.74e-15	70.1	COG2154@1|root,COG2154@2|Bacteria,1G7P9@1117|Cyanobacteria,1H11A@1129|Synechococcus	1117|Cyanobacteria	H	pterin-4-alpha-carbinolamine dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
k59_659412_1	1454010.JEOE01000065_gene2083	4.33e-15	75.9	COG1215@1|root,COG1215@2|Bacteria,2GJTE@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
k59_659412_2	1121382.JQKG01000081_gene877	1.21e-07	56.2	COG1226@1|root,COG1226@2|Bacteria	2|Bacteria	P	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)	kcsA	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,Ion_trans_2
k59_1715079_1	1068978.AMETH_5253	6.8e-14	81.3	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria,4DX8K@85010|Pseudonocardiales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
k59_541557_1	1429046.RR21198_2135	3.35e-74	236.0	COG0477@1|root,COG2814@2|Bacteria,2GNBV@201174|Actinobacteria,4FWA7@85025|Nocardiaceae	201174|Actinobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_22119_1	1307759.JOMJ01000003_gene389	1.61e-71	236.0	COG0493@1|root,COG2878@1|root,COG0493@2|Bacteria,COG2878@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2WIVF@28221|Deltaproteobacteria,2M9TK@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Fe-S cluster domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fer4,Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3
k59_482791_2	1304883.KI912532_gene2115	3.43e-73	222.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2VR4W@28216|Betaproteobacteria,2KWIG@206389|Rhodocyclales	206389|Rhodocyclales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
k59_958514_1	498761.HM1_0751	3.57e-44	155.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia	186801|Clostridia	L	hydrolase, TatD family	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
k59_541570_1	1121405.dsmv_1968	3.25e-69	213.0	COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,42U8S@68525|delta/epsilon subdivisions,2WQ8V@28221|Deltaproteobacteria,2MKT7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	nuoE-1	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_541570_2	1121405.dsmv_1967	4.18e-53	184.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MMTC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.12.1.3,1.6.5.3	ko:K00124,ko:K00335,ko:K05587,ko:K18331	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_659431_1	2340.JV46_14450	7.38e-22	87.8	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,1J670@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
k59_1838884_1	1278073.MYSTI_05597	9.2e-66	215.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2WJB0@28221|Deltaproteobacteria,2YWEI@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_1838884_2	518766.Rmar_0949	3.22e-26	107.0	COG1763@1|root,COG1763@2|Bacteria,4PM6G@976|Bacteroidetes,1FK05@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Mo-molybdopterin cofactor biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_131136_1	652103.Rpdx1_0729	2.12e-45	166.0	COG0493@1|root,COG0543@1|root,COG1633@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,COG1633@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2
k59_1009796_1	1335757.SPICUR_06990	4.82e-35	133.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1WW7J@135613|Chromatiales	135613|Chromatiales	F	Ribonucleotide reductase, barrel domain	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_600576_1	765913.ThidrDRAFT_0395	1.03e-195	551.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1WWGC@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_600576_2	754476.Q7A_2011	1.86e-10	61.6	COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,460Q9@72273|Thiotrichales	72273|Thiotrichales	EH	PFAM Aminotransferase, class IV	-	-	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	-	Aminotran_4
k59_774854_1	765910.MARPU_15360	1.88e-06	49.7	COG1563@1|root,COG1563@2|Bacteria,1RB3N@1224|Proteobacteria,1S4P7@1236|Gammaproteobacteria,1WY79@135613|Chromatiales	135613|Chromatiales	P	Domain related to MnhB subunit of Na+/H+ antiporter	-	-	-	-	-	-	-	-	-	-	-	-	MnhB
k59_774854_2	765913.ThidrDRAFT_4027	5.75e-29	106.0	COG1006@1|root,COG1006@2|Bacteria,1N7TX@1224|Proteobacteria,1SD0U@1236|Gammaproteobacteria,1WYVT@135613|Chromatiales	135613|Chromatiales	P	oxidoreductase, chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
k59_774854_3	1123368.AUIS01000004_gene136	2.56e-67	223.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RYB4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter MnhD subunit	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M,Proton_antipo_N
k59_1076283_1	471853.Bcav_2159	2.63e-99	298.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	xerD	GO:0008150,GO:0040007	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1658432_1	318996.AXAZ01000055_gene6355	2.31e-87	293.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
k59_78754_1	1333998.M2A_0749	3.74e-46	158.0	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2TVBT@28211|Alphaproteobacteria,4BQT1@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
k59_1188654_1	1158050.KB895461_gene2907	5.68e-90	292.0	COG1215@1|root,COG1216@1|root,COG1922@1|root,COG1215@2|Bacteria,COG1216@2|Bacteria,COG1922@2|Bacteria,2IFW3@201174|Actinobacteria,1W987@1268|Micrococcaceae	201174|Actinobacteria	M	glycosyl transferase, WecB TagA CpsF family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_WecB,Glycos_transf_2
k59_1009809_1	864069.MicloDRAFT_00003420	2.36e-85	262.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JW30@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_959603_1	264198.Reut_A3025	1.14e-15	81.3	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2VH7F@28216|Betaproteobacteria,1K17M@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
k59_1127435_1	472759.Nhal_3574	2.74e-77	239.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1WW4R@135613|Chromatiales	135613|Chromatiales	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
k59_1598274_1	1304865.JAGF01000001_gene3670	2.03e-101	325.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2GMFD@201174|Actinobacteria,4F0PI@85016|Cellulomonadaceae	201174|Actinobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_372361_1	667014.Thein_0076	1.76e-21	95.5	COG1624@1|root,COG1624@2|Bacteria,2GGVH@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
k59_1774288_1	296591.Bpro_1191	8.55e-241	700.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,4A9Z9@80864|Comamonadaceae	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_1188664_1	305900.GV64_02040	5.35e-105	330.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XI69@135619|Oceanospirillales	135619|Oceanospirillales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_959617_1	1122951.ATUE01000006_gene933	1.88e-14	69.3	COG2261@1|root,COG2261@2|Bacteria,1N72Y@1224|Proteobacteria,1SCD4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM Transglycosylase-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
k59_483537_1	1298593.TOL_1533	5.66e-58	189.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,1RMK2@1236|Gammaproteobacteria,1XHYZ@135619|Oceanospirillales	135619|Oceanospirillales	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_774872_2	1123393.KB891316_gene1708	3.92e-74	232.0	COG0730@1|root,COG0730@2|Bacteria,1MX4T@1224|Proteobacteria,2VRZJ@28216|Betaproteobacteria,1KS67@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
k59_660259_1	1307436.PBF_14684	5.33e-16	83.2	COG3547@1|root,COG3547@2|Bacteria,1V427@1239|Firmicutes,4HGY6@91061|Bacilli,1ZERT@1386|Bacillus	91061|Bacilli	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_900638_1	935839.JAGJ01000013_gene2873	4.44e-77	248.0	COG1112@1|root,COG1112@2|Bacteria,2H3MV@201174|Actinobacteria	201174|Actinobacteria	L	Type III restriction enzyme res subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,NERD,UvrD_C_2
k59_1485775_1	1283283.ATXA01000005_gene2072	3.08e-37	140.0	COG0673@1|root,COG0673@2|Bacteria,2GN2Z@201174|Actinobacteria,4ESD5@85013|Frankiales	201174|Actinobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_660260_1	713586.KB900536_gene2942	4.46e-77	239.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,1RM8D@1236|Gammaproteobacteria,1WWMY@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_660260_2	1348657.M622_10260	0.000254	43.9	COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,2VQ8U@28216|Betaproteobacteria,2KW52@206389|Rhodocyclales	206389|Rhodocyclales	F	Deoxynucleoside kinase	-	-	-	-	-	-	-	-	-	-	-	-	dNK
k59_542356_1	1504319.GM45_0280	1.09e-27	107.0	COG1738@1|root,COG1738@2|Bacteria,2IFDB@201174|Actinobacteria,3UX0S@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	U	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
k59_542356_2	1449347.JQLN01000005_gene4707	2.26e-05	47.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,2M05F@2063|Kitasatospora	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
k59_23090_1	313612.L8106_02202	3.57e-210	599.0	COG2192@1|root,COG2192@2|Bacteria,1G1FV@1117|Cyanobacteria,1H9E9@1150|Oscillatoriales	1117|Cyanobacteria	O	carbamoyl transferase, NodU family	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
k59_372384_1	237368.SCABRO_00954	2.14e-80	253.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
k59_1423661_1	667014.Thein_0579	1.34e-60	206.0	COG0317@1|root,COG0317@2|Bacteria,2GHKR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_190582_1	335543.Sfum_0824	3.45e-198	585.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria,2MQTQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.17.1.10,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388,ko:K15022	ko00680,ko00720,ko01100,ko01120,ko01200,map00680,map00720,map01100,map01120,map01200	M00356,M00357,M00377,M00563,M00567	R00134,R04540,R11928,R11931,R11943,R11944	RC00011,RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_835969_1	234267.Acid_7883	3.74e-15	80.1	COG1432@1|root,COG1432@2|Bacteria,3Y64C@57723|Acidobacteria	57723|Acidobacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
k59_372404_2	1296990.H845_1013	2.57e-95	283.0	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,2JSK6@204441|Rhodospirillales	204441|Rhodospirillales	L	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_256709_1	1353537.TP2_00585	1.01e-66	231.0	COG0771@1|root,COG2911@1|root,COG2931@1|root,COG4625@1|root,COG4935@1|root,COG0771@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,COG4935@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,DUF4214,HemolysinCabind,Hint_2
k59_1721472_1	1121939.L861_00505	1.55e-55	185.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1XIUA@135619|Oceanospirillales	135619|Oceanospirillales	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
k59_264811_1	399795.CtesDRAFT_PD1357	5.76e-41	151.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,4AAIW@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM Phospholipase D Transphosphatidylase	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_841346_1	768066.HELO_4443	2.88e-07	50.8	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,1S25H@1236|Gammaproteobacteria,1XK0R@135619|Oceanospirillales	135619|Oceanospirillales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
k59_841346_2	641149.HMPREF9016_01059	2.99e-30	114.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,2VQA2@28216|Betaproteobacteria,2KQVZ@206351|Neisseriales	206351|Neisseriales	G	Psort location Cytoplasmic, score	slyD	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
k59_841346_3	566466.NOR53_3592	1.94e-31	121.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1J8QC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009226,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0018130,GO:0019134,GO:0019438,GO:0030203,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0042546,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046872,GO:0055086,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903509	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iECED1_1282.ECED1_4420,iYL1228.KPN_04135	Hexapep,Hexapep_2,NTP_transf_3
k59_1492213_1	1267005.KB911255_gene2565	5.39e-96	294.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2TQU6@28211|Alphaproteobacteria,3N6CH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Mg chelatase subunit ChlI	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_1257609_1	153948.NAL212_0013	8.39e-106	311.0	COG3676@1|root,COG3676@2|Bacteria,1QTF7@1224|Proteobacteria,2VSUV@28216|Betaproteobacteria	28216|Betaproteobacteria	L	ISXO2-like transposase domain	-	-	-	ko:K07488	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1595
k59_967216_2	879212.DespoDRAFT_00366	5.24e-11	63.9	COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42YWX@68525|delta/epsilon subdivisions,2WU5V@28221|Deltaproteobacteria,2MMX6@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HD,HD_5
k59_30957_1	159087.Daro_1840	3.46e-27	108.0	28K4S@1|root,2Z9TM@2|Bacteria,1N4AQ@1224|Proteobacteria,2VK2F@28216|Betaproteobacteria,2KV3C@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_30957_2	713587.THITH_15240	1.8e-27	107.0	COG0526@1|root,COG0526@2|Bacteria,1N4P6@1224|Proteobacteria,1SB0P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
k59_1319468_1	1042377.AFPJ01000051_gene36	1.83e-88	273.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,4655S@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	ABC-2 family transporter protein	ybhS	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_1779990_1	396588.Tgr7_2187	1.3e-61	191.0	COG1553@1|root,COG1553@2|Bacteria,1N021@1224|Proteobacteria,1S99J@1236|Gammaproteobacteria,1WY2D@135613|Chromatiales	135613|Chromatiales	P	TIGRFAM sulfur relay protein TusD DsrE	dsrE	GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0019417,GO:0044237,GO:0055114	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
k59_1493133_1	929562.Emtol_0826	5.91e-61	205.0	COG0446@1|root,COG0446@2|Bacteria,4NEK6@976|Bacteroidetes,47N6I@768503|Cytophagia	976|Bacteroidetes	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
k59_909272_1	643648.Slip_2357	2.28e-32	120.0	COG0517@1|root,COG0517@2|Bacteria,1V0XU@1239|Firmicutes,24I2P@186801|Clostridia,42JYZ@68298|Syntrophomonadaceae	186801|Clostridia	S	PFAM CBS domain containing protein	acuB	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
k59_780146_1	446466.Cfla_2207	2.7e-103	326.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_32271_1	105559.Nwat_2897	3.31e-220	620.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1WW1X@135613|Chromatiales	135613|Chromatiales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
k59_32271_2	1301098.PKB_5639	3.27e-20	90.1	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_1722185_1	1286106.MPL1_03353	1.67e-249	705.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,45ZQH@72273|Thiotrichales	72273|Thiotrichales	E	peptidase	-	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_1848653_1	999541.bgla_1g21880	5.61e-33	121.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2VSEK@28216|Betaproteobacteria,1K1I0@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE8	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_968255_1	1713.JOFV01000005_gene2138	1.22e-43	162.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,4F0FB@85016|Cellulomonadaceae	201174|Actinobacteria	L	TIGRFAM ATP-dependent DNA helicase PcrA	pcrA	GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1320509_1	396588.Tgr7_0732	4.52e-85	263.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1WXKK@135613|Chromatiales	135613|Chromatiales	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_1320509_2	1174529.WSI_04175	1.51e-13	66.6	COG0271@1|root,COG0271@2|Bacteria,1R3MM@1224|Proteobacteria,2UBUW@28211|Alphaproteobacteria,4BG4G@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Belongs to the BolA IbaG family	MA20_09125	-	-	-	-	-	-	-	-	-	-	-	BolA
k59_1320509_3	1249627.D779_0306	6.37e-62	202.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1WXB6@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_1493155_1	96561.Dole_2551	3.22e-68	220.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,42MJT@68525|delta/epsilon subdivisions,2WJ7W@28221|Deltaproteobacteria,2MHNI@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_724716_1	880072.Desac_0095	2.1e-76	239.0	COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria	1224|Proteobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,Response_reg
k59_1546127_1	1499684.CCNP01000018_gene769	1.61e-13	72.4	COG0584@1|root,COG0584@2|Bacteria,1V404@1239|Firmicutes,24EP5@186801|Clostridia,36JF3@31979|Clostridiaceae	186801|Clostridia	C	Domain of unknown function	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	DUF4996,GDPD
k59_381020_1	383372.Rcas_2362	1.56e-102	321.0	COG5322@1|root,COG5322@2|Bacteria,2G7SR@200795|Chloroflexi,377XP@32061|Chloroflexia	32061|Chloroflexia	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1133283_1	227377.CBU_1713	1.41e-30	119.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1JD0B@118969|Legionellales	118969|Legionellales	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
k59_1133283_2	323261.Noc_2548	7.92e-116	339.0	COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria,1WZWK@135613|Chromatiales	135613|Chromatiales	G	pfkB family carbohydrate kinase	-	-	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_430882_1	1004149.AFOE01000036_gene824	2.03e-71	236.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,4NDXY@976|Bacteroidetes,1HWZP@117743|Flavobacteriia	976|Bacteroidetes	M	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	POTRA,Patatin
k59_313800_1	1123392.AQWL01000011_gene2230	1.17e-144	430.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VI20@28216|Betaproteobacteria,1KS05@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_1320526_1	358220.C380_01350	3.03e-08	60.5	COG1538@1|root,COG4319@1|root,COG1538@2|Bacteria,COG4319@2|Bacteria,1MYX2@1224|Proteobacteria,2VKDN@28216|Betaproteobacteria,4ABJI@80864|Comamonadaceae	28216|Betaproteobacteria	MU	type I secretion outer membrane protein, TolC family	-	-	-	ko:K12543	-	M00330	-	-	ko00000,ko00002,ko02000,ko02044	1.B.17,3.A.1.109.4	-	-	OEP,OmpA
k59_1664799_1	713586.KB900536_gene2967	5.03e-72	240.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales	135613|Chromatiales	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HTH_12,OB_RNB,RNB,S1
k59_842104_1	1121374.KB891586_gene2791	2.82e-37	139.0	COG3182@1|root,COG3182@2|Bacteria,1QVX4@1224|Proteobacteria,1T2MJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PepSY-associated TM region	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_TM
k59_842104_2	1198232.CYCME_2426	6.16e-55	178.0	COG4659@1|root,COG4659@2|Bacteria,1MZVX@1224|Proteobacteria,1S9KJ@1236|Gammaproteobacteria,46102@72273|Thiotrichales	72273|Thiotrichales	C	FMN_bind	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
k59_1133295_1	288000.BBta_1747	7.54e-16	75.1	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2TTJF@28211|Alphaproteobacteria,3JR5X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	coxM	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_1133295_2	398580.Dshi_1209	9.01e-15	74.3	COG3279@1|root,COG3300@1|root,COG3279@2|Bacteria,COG3300@2|Bacteria,1PXIQ@1224|Proteobacteria,2TT3B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KT	Carbon monoxide dehydrogenase operon C protein	coxC	GO:0006355,GO:0006808,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K21696	-	-	-	-	ko00000,ko03000	-	-	-	LytTR,MHYT
k59_196624_1	765912.Thimo_3426	2.44e-86	270.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,1QU7C@1224|Proteobacteria,1T1PS@1236|Gammaproteobacteria,1WVXX@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_196624_2	338966.Ppro_2228	1.06e-56	182.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,42QPB@68525|delta/epsilon subdivisions,2WMP0@28221|Deltaproteobacteria,43T71@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	response regulator	-	-	-	ko:K07664	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_381036_1	194439.CT0676	1.41e-120	368.0	COG2865@1|root,COG2865@2|Bacteria,1FFIP@1090|Chlorobi	1090|Chlorobi	-	-	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
k59_313811_1	1286631.X805_05290	1.75e-88	272.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2VH2M@28216|Betaproteobacteria,1KJSC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	-	-	-	-	-	-	-	-	-	-	-	-	Iso_dh
k59_430899_1	1123401.JHYQ01000018_gene2377	1.02e-56	187.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,460E8@72273|Thiotrichales	72273|Thiotrichales	J	Methylates ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
k59_430899_2	396588.Tgr7_0364	3.48e-09	57.8	COG1273@1|root,COG1273@2|Bacteria,1MWCU@1224|Proteobacteria,1S892@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3426)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3426,zinc_ribbon_5
k59_606970_1	859657.RPSI07_2236	2.9e-31	117.0	COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,2VHB2@28216|Betaproteobacteria,1K1H7@119060|Burkholderiaceae	28216|Betaproteobacteria	S	SMART phosphoesterase PHP domain protein	-	GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0097657	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
k59_606970_2	1095769.CAHF01000010_gene1222	1.01e-16	78.6	COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2VMEV@28216|Betaproteobacteria,47249@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_724749_1	880072.Desac_2814	4.78e-143	417.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2MQFX@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta)	-	-	2.1.3.1,2.1.3.15,6.4.1.3	ko:K01966,ko:K17489	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R00353,R01859	RC00040,RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_666305_1	1286171.EAL2_c04450	6.36e-08	52.4	COG0315@1|root,COG0315@2|Bacteria,1V3J4@1239|Firmicutes,24H9F@186801|Clostridia,25WTI@186806|Eubacteriaceae	186801|Clostridia	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
k59_666305_2	335543.Sfum_2611	7.7e-37	128.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,42RVK@68525|delta/epsilon subdivisions,2WNNA@28221|Deltaproteobacteria,2MRZS@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	PFAM zinc finger, DksA TraR C4-type	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
k59_1604308_2	1279015.KB908465_gene132	3.07e-36	127.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1S9P2@1236|Gammaproteobacteria,1Y5ZG@135624|Aeromonadales	135624|Aeromonadales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1
k59_489766_1	1356854.N007_03930	5.31e-67	215.0	COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,4H9RK@91061|Bacilli,2787Y@186823|Alicyclobacillaceae	91061|Bacilli	NU	Type II/IV secretion system protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_1493202_1	580332.Slit_1116	1.52e-38	140.0	COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,2VIQI@28216|Betaproteobacteria	28216|Betaproteobacteria	K	CRP FNR family	dnrD	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_1493202_2	568706.BN118_3542	2.88e-06	50.8	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,3T2MK@506|Alcaligenaceae	28216|Betaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3,OmpA
k59_548291_1	1121405.dsmv_1442	4.31e-111	351.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2MI79@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_489767_2	1244869.H261_09854	1.51e-70	226.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,2TYKR@28211|Alphaproteobacteria,2JQJI@204441|Rhodospirillales	204441|Rhodospirillales	C	Nickel-dependent hydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
k59_666311_1	875328.JDM601_3502	1.27e-22	95.5	COG2128@1|root,COG2128@2|Bacteria,2IAT6@201174|Actinobacteria,238XY@1762|Mycobacteriaceae	201174|Actinobacteria	S	carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_1848737_2	96561.Dole_0031	0.000306	45.1	COG1463@1|root,COG1463@2|Bacteria,1PP5K@1224|Proteobacteria,43EVP@68525|delta/epsilon subdivisions,2WT7Z@28221|Deltaproteobacteria,2MP7C@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_266148_2	1306174.JODP01000013_gene7716	5.49e-57	193.0	COG1523@1|root,COG1523@2|Bacteria,2H92B@201174|Actinobacteria	201174|Actinobacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
k59_138072_1	1238450.VIBNISOn1_830107	1.24e-19	92.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,1XT0M@135623|Vibrionales	135623|Vibrionales	M	protein conserved in bacteria	-	-	-	ko:K16291,ko:K19236	ko01503,map01503	-	-	-	ko00000,ko00001,ko01002,ko01011	-	-	-	LysM,YkuD
k59_1664842_1	765913.ThidrDRAFT_4193	4.29e-25	102.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1WZ4R@135613|Chromatiales	135613|Chromatiales	BQ	PFAM histone deacetylase superfamily	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
k59_1664842_2	1121405.dsmv_3532	2.27e-50	177.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,42P6S@68525|delta/epsilon subdivisions,2WIWC@28221|Deltaproteobacteria,2MI1I@213118|Desulfobacterales	28221|Deltaproteobacteria	EQ	PFAM Hydantoinase oxoprolinase	-	-	-	-	-	-	-	-	-	-	-	-	Hydant_A_N,Hydantoinase_A
k59_87536_1	631362.Thi970DRAFT_01782	5.62e-27	115.0	COG0651@1|root,COG0651@2|Bacteria,1N6BY@1224|Proteobacteria,1RR4C@1236|Gammaproteobacteria,1WWFY@135613|Chromatiales	135613|Chromatiales	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,Proton_antipo_M
k59_548299_1	518766.Rmar_2195	2.19e-75	235.0	COG0320@1|root,COG0320@2|Bacteria,4NEB5@976|Bacteroidetes,1FIV9@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_489773_1	697282.Mettu_0059	1.27e-35	129.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,1RPYX@1236|Gammaproteobacteria,1XDV7@135618|Methylococcales	135618|Methylococcales	O	Glycoprotease family	-	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
k59_489773_2	1121013.P873_02785	2.39e-69	229.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1X3ZE@135614|Xanthomonadales	135614|Xanthomonadales	KL	Helicase	yoaA	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2,ResIII
k59_1722256_1	1713.JOFV01000013_gene1037	2.13e-127	378.0	COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria,4F0IV@85016|Cellulomonadaceae	201174|Actinobacteria	O	PFAM AAA ATPase central domain protein	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
k59_430930_1	1198232.CYCME_0807	6.96e-16	78.6	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,460QS@72273|Thiotrichales	72273|Thiotrichales	S	TIGRFAM TIGR02099 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_32417_1	1125699.HMPREF9194_00767	8.46e-19	90.1	COG0849@1|root,COG0849@2|Bacteria,2J5UK@203691|Spirochaetes	203691|Spirochaetes	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_1604329_1	420324.KI911965_gene909	6.21e-63	203.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TS33@28211|Alphaproteobacteria,1JQTK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Cysteine synthase A	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1722261_1	883126.HMPREF9710_02652	3.14e-11	65.9	COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,2VIQI@28216|Betaproteobacteria,4747S@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Cyclic nucleotide-monophosphate binding domain	dnrD	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_1320606_1	243233.MCA1143	1.65e-24	97.4	COG4636@1|root,COG4636@2|Bacteria,1RGFC@1224|Proteobacteria,1S3SY@1236|Gammaproteobacteria,1XGBA@135618|Methylococcales	135618|Methylococcales	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
k59_1320606_2	572477.Alvin_1772	5.13e-69	219.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1WVVQ@135613|Chromatiales	135613|Chromatiales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_87548_2	1283299.AUKG01000002_gene4030	4.67e-47	161.0	COG3246@1|root,COG3246@2|Bacteria,2I9EQ@201174|Actinobacteria,4CRZM@84995|Rubrobacteria	84995|Rubrobacteria	S	beta-keto acid cleavage enzyme	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
k59_138086_1	367299.JOEE01000001_gene2005	2.24e-182	513.0	COG0506@1|root,COG0506@2|Bacteria,2GJTK@201174|Actinobacteria,4FEKP@85021|Intrasporangiaceae	201174|Actinobacteria	E	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
k59_489782_2	1454004.AW11_02489	6.28e-135	390.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,2VTJU@28216|Betaproteobacteria	28216|Betaproteobacteria	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_32434_1	745014.OMB55_00000680	5.93e-80	248.0	COG2304@1|root,COG2304@2|Bacteria,1QBPM@1224|Proteobacteria,1RQIU@1236|Gammaproteobacteria,1J4PZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Secreted protein, containing von Willebrand factor (VWF) type	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_196667_1	1496688.ER33_14805	6.42e-115	343.0	COG5361@1|root,COG5361@2|Bacteria,1G1YW@1117|Cyanobacteria,22TKK@167375|Cyanobium	1117|Cyanobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_847473_2	1267534.KB906754_gene2855	1.82e-21	94.0	COG1668@1|root,COG1668@2|Bacteria,3Y2XV@57723|Acidobacteria,2JIQK@204432|Acidobacteriia	204432|Acidobacteriia	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_977877_1	1348657.M622_02405	6.98e-37	132.0	COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,2VIZ2@28216|Betaproteobacteria,2KVFF@206389|Rhodocyclales	206389|Rhodocyclales	S	HAD-superfamily hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_977877_2	558884.JRGM01000043_gene1325	5.03e-49	165.0	COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,1S3TQ@1236|Gammaproteobacteria,1Y4DG@135624|Aeromonadales	135624|Aeromonadales	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_97004_1	395493.BegalDRAFT_1677	4.95e-223	637.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,45ZV1@72273|Thiotrichales	72273|Thiotrichales	O	ATP-dependent Clp protease ATP-binding subunit ClpA	-	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_436253_1	1121447.JONL01000001_gene993	1.03e-07	52.0	COG0316@1|root,COG0316@2|Bacteria,1N8FK@1224|Proteobacteria,42VBF@68525|delta/epsilon subdivisions,2WR7Y@28221|Deltaproteobacteria,2MCQR@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Belongs to the HesB IscA family	-	-	-	-	-	-	-	-	-	-	-	-	Fe-S_biosyn
k59_1858364_1	396588.Tgr7_1070	1.58e-68	224.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1X01C@135613|Chromatiales	135613|Chromatiales	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	1.16.1.1	ko:K00520	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1858364_2	522306.CAP2UW1_2824	5.92e-49	165.0	COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,2VKSA@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF3641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
k59_143247_1	458817.Shal_1276	4.32e-91	298.0	COG0834@1|root,COG1301@1|root,COG0834@2|Bacteria,COG1301@2|Bacteria,1P22C@1224|Proteobacteria,1RSGY@1236|Gammaproteobacteria,2QBG7@267890|Shewanellaceae	1236|Gammaproteobacteria	P	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3,SDF
k59_612336_2	1304865.JAGF01000001_gene2828	4.11e-28	109.0	COG0711@1|root,COG0711@2|Bacteria,2GNBF@201174|Actinobacteria,4F1F7@85016|Cellulomonadaceae	201174|Actinobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_436256_1	757424.Hsero_4158	4.48e-13	63.9	2CDU3@1|root,33AS4@2|Bacteria,1NGWQ@1224|Proteobacteria,2VXNC@28216|Betaproteobacteria,4754U@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF2970)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2970
k59_436256_2	748280.NH8B_3842	1.41e-50	169.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VJAP@28216|Betaproteobacteria,2KQDS@206351|Neisseriales	206351|Neisseriales	C	oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_40342_1	502025.Hoch_4386	2.26e-09	58.2	COG0727@1|root,COG0727@2|Bacteria,1N1SQ@1224|Proteobacteria,434D5@68525|delta/epsilon subdivisions,2WYQ6@28221|Deltaproteobacteria,2Z0CN@29|Myxococcales	28221|Deltaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
k59_495027_1	583355.Caka_0079	1.87e-40	148.0	COG0815@1|root,COG0815@2|Bacteria,46W4F@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Transfers the fatty acyl group on membrane lipoproteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_977896_1	67281.JNZZ01000002_gene2603	1.39e-08	61.2	COG0702@1|root,COG0702@2|Bacteria,2GKXI@201174|Actinobacteria,417BD@629295|Streptomyces griseus group	201174|Actinobacteria	GM	PFAM NmrA family protein	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
k59_1609289_1	880072.Desac_0172	1.73e-67	226.0	COG1680@1|root,COG3876@1|root,COG1680@2|Bacteria,COG3876@2|Bacteria,1MVPR@1224|Proteobacteria,42TQ5@68525|delta/epsilon subdivisions,2WQ0T@28221|Deltaproteobacteria,2MRV7@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_97028_1	1265313.HRUBRA_01697	3.3e-91	291.0	COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,1RPD2@1236|Gammaproteobacteria,1J4T5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_16,TPR_19,TPR_20,TPR_8
k59_918801_1	1167006.UWK_01034	1.02e-05	47.4	COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,42MBX@68525|delta/epsilon subdivisions,2WJYG@28221|Deltaproteobacteria,2MJBW@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM periplasmic solute binding protein	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
k59_918801_2	517417.Cpar_0139	8.84e-45	154.0	COG1121@1|root,COG1121@2|Bacteria,1FEP4@1090|Chlorobi	1090|Chlorobi	P	PFAM ABC transporter related	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
k59_40354_1	1033802.SSPSH_003111	1.3e-82	274.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_918807_1	439235.Dalk_2894	5.98e-51	181.0	COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria,2MI6S@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS,PAS_3,PAS_9,Response_reg
k59_1609291_1	367299.JOEE01000008_gene626	2.45e-229	668.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria,4FEMU@85021|Intrasporangiaceae	201174|Actinobacteria	E	MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_977916_1	391165.GbCGDNIH1_0821	7.76e-11	60.8	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,2TU3N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Anthranilate synthase	trpG	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_977916_2	948565.AFFP02000013_gene1928	3.42e-53	173.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,1Y784@135625|Pasteurellales	135625|Pasteurellales	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_436271_1	1502852.FG94_03786	1.36e-68	226.0	COG0303@1|root,COG0746@1|root,COG0303@2|Bacteria,COG0746@2|Bacteria,1MVD5@1224|Proteobacteria,2VH78@28216|Betaproteobacteria,473QZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	moeA2	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_1330141_1	1380356.JNIK01000002_gene4843	4.23e-66	214.0	COG0582@1|root,COG0582@2|Bacteria,2GTYQ@201174|Actinobacteria,4EW1T@85013|Frankiales	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
k59_1670263_2	1267005.KB911261_gene2259	1.22e-118	373.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2TS7S@28211|Alphaproteobacteria,3N6C4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1609306_1	502025.Hoch_0546	7.69e-39	143.0	COG0539@1|root,COG0539@2|Bacteria,1N2EJ@1224|Proteobacteria,42NXS@68525|delta/epsilon subdivisions,2WJ0A@28221|Deltaproteobacteria,2YV19@29|Myxococcales	28221|Deltaproteobacteria	J	Ribosomal protein S1-like RNA-binding domain	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_97066_1	1187851.A33M_1392	2.25e-125	384.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,3FCY5@34008|Rhodovulum	1224|Proteobacteria	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,NAD_binding_1,Pyr_redox_2
k59_143275_2	1123070.KB899252_gene926	3.22e-58	196.0	COG3653@1|root,COG3653@2|Bacteria	2|Bacteria	Q	N-Acyl-D-aspartate D-glutamate deacylase	MA20_04810	-	3.5.1.82	ko:K01461	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_3
k59_495061_1	887062.HGR_14764	2.27e-51	184.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,4AA9F@80864|Comamonadaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_7,PAS_9,Response_reg
k59_1264775_1	335543.Sfum_1925	4.11e-47	171.0	COG0699@1|root,COG0699@2|Bacteria,1R3WJ@1224|Proteobacteria,42N0G@68525|delta/epsilon subdivisions,2WKFJ@28221|Deltaproteobacteria,2MRED@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_784725_1	754476.Q7A_2284	1.09e-10	62.8	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,45ZNE@72273|Thiotrichales	72273|Thiotrichales	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
k59_784725_2	1122201.AUAZ01000021_gene3194	2.78e-17	83.6	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,464MZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_612371_2	367299.JOEE01000008_gene387	1.7e-59	189.0	COG2839@1|root,COG2839@2|Bacteria,2IQDE@201174|Actinobacteria,4FH1V@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF456)	-	-	-	ko:K09793	-	-	-	-	ko00000	-	-	-	DUF456
k59_918855_1	367299.JOEE01000011_gene3190	5.62e-80	255.0	COG0747@1|root,COG0747@2|Bacteria,2GJXH@201174|Actinobacteria,4FEG1@85021|Intrasporangiaceae	201174|Actinobacteria	E	ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1670284_2	983917.RGE_30130	8.05e-83	251.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2VNRC@28216|Betaproteobacteria,1KPGD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07666	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1090697_2	1469245.JFBG01000001_gene538	6.38e-94	284.0	COG1073@1|root,COG1073@2|Bacteria,1N1WH@1224|Proteobacteria,1S9JK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	DUF3530
k59_1858456_1	228410.NE1698	2.29e-167	475.0	COG3677@1|root,COG3677@2|Bacteria,1R999@1224|Proteobacteria,2W3K1@28216|Betaproteobacteria,374PB@32003|Nitrosomonadales	28216|Betaproteobacteria	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,HTH_23
k59_1609323_1	1122929.KB908219_gene1787	8.66e-91	278.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_273637_1	1049564.TevJSym_at00640	2.19e-140	407.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1J4I3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Ammonium Transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_672392_1	768671.ThimaDRAFT_1206	2.15e-79	256.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1WVZ6@135613|Chromatiales	135613|Chromatiales	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF3340,PDZ,Peptidase_S41
k59_1436185_1	1123401.JHYQ01000018_gene2373	1.16e-159	461.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,1RPYD@1236|Gammaproteobacteria,45ZVB@72273|Thiotrichales	72273|Thiotrichales	S	Bacterial protein of unknown function (DUF853)	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
k59_785381_1	580332.Slit_0524	8.72e-107	313.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2VHY3@28216|Betaproteobacteria,44V5Y@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
k59_554493_2	383372.Rcas_0129	2.49e-14	76.6	COG0531@1|root,COG0531@2|Bacteria,2G76Z@200795|Chloroflexi	200795|Chloroflexi	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,AA_permease_2
k59_320090_1	1122179.KB890443_gene1211	2.09e-38	146.0	COG0457@1|root,COG2114@1|root,COG2207@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG2207@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IR3J@117747|Sphingobacteriia	976|Bacteroidetes	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,Guanylate_cyc,HTH_18,TPR_16,TPR_8
k59_1728551_1	1286106.MPL1_04080	2.01e-13	68.9	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,1RM8D@1236|Gammaproteobacteria,4609A@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_1728551_2	1234364.AMSF01000015_gene3255	5.5e-87	267.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1X3FN@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
k59_848317_1	65497.JODV01000007_gene534	7.68e-122	353.0	COG0447@1|root,COG0447@2|Bacteria,2GK5G@201174|Actinobacteria,4E09A@85010|Pseudonocardiales	201174|Actinobacteria	H	Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily	menB	-	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_672397_1	396588.Tgr7_0333	2.08e-75	238.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1WWMQ@135613|Chromatiales	135613|Chromatiales	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_785383_1	768671.ThimaDRAFT_0894	2.95e-45	148.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,1S5VB@1236|Gammaproteobacteria,1WYVV@135613|Chromatiales	135613|Chromatiales	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
k59_320093_1	587753.EY04_24650	3.24e-42	145.0	COG0500@1|root,COG0500@2|Bacteria,1R4H7@1224|Proteobacteria,1S55S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	sam-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
k59_848326_1	395493.BegalDRAFT_3457	4.03e-71	226.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,45ZYD@72273|Thiotrichales	72273|Thiotrichales	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
k59_613173_1	1122214.AQWH01000039_gene4763	6.69e-80	255.0	COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,2TTBA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_672410_1	765912.Thimo_2579	1.16e-171	494.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1WX2I@135613|Chromatiales	135613|Chromatiales	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
k59_495897_1	2340.JV46_15810	5.42e-95	291.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1J4RF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the MurCDEF family	murC	GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iECP_1309.ECP_0093	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_920362_1	342113.DM82_4886	4.73e-43	151.0	COG1796@1|root,COG1796@2|Bacteria,1QF8Z@1224|Proteobacteria,2WASJ@28216|Betaproteobacteria,1K40Q@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Helix-hairpin-helix domain	-	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	HHH_5,HHH_8
k59_274791_1	710685.MycrhN_2168	1.33e-37	135.0	COG1087@1|root,COG1087@2|Bacteria,2GMCW@201174|Actinobacteria,23FA5@1762|Mycobacteriaceae	201174|Actinobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE1	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_274791_2	767029.HMPREF9154_2602	1.8e-16	80.1	COG4284@1|root,COG4284@2|Bacteria,2I2G3@201174|Actinobacteria,4DPKI@85009|Propionibacteriales	201174|Actinobacteria	G	UTP--glucose-1-phosphate uridylyltransferase	ugp	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPGP
k59_920367_1	765913.ThidrDRAFT_0856	4.81e-64	204.0	COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,1RNAA@1236|Gammaproteobacteria,1WWKH@135613|Chromatiales	135613|Chromatiales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1265817_1	941449.dsx2_3189	2.89e-41	142.0	COG2009@1|root,2ZBTX@2|Bacteria,1RB22@1224|Proteobacteria,42NAY@68525|delta/epsilon subdivisions,2WMPM@28221|Deltaproteobacteria,2M7WC@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM fumarate reductase respiratory complex	-	-	-	ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_554523_2	1121405.dsmv_1822	3.48e-09	59.7	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,42MS6@68525|delta/epsilon subdivisions,2WIYE@28221|Deltaproteobacteria,2MJNV@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_392020_1	1318628.MARLIPOL_06709	6.31e-16	75.5	COG4122@1|root,COG4122@2|Bacteria,1QXFR@1224|Proteobacteria,1T3AR@1236|Gammaproteobacteria,466XS@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF938)	-	-	-	-	-	-	-	-	-	-	-	-	DUF938
k59_1091684_1	1265505.ATUG01000001_gene4291	3.91e-65	211.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42MWJ@68525|delta/epsilon subdivisions,2WJ8Q@28221|Deltaproteobacteria,2MHKY@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_1201145_1	1121948.AUAC01000003_gene2507	3.57e-27	111.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,43WFJ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs	iorB	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_1331702_1	1265505.ATUG01000001_gene3622	1.54e-146	425.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,2MHKB@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
k59_1552040_1	1522072.IL54_2604	9.51e-19	85.5	COG0823@1|root,COG0823@2|Bacteria,1MUK9@1224|Proteobacteria,2UQ6N@28211|Alphaproteobacteria,2K0RY@204457|Sphingomonadales	204457|Sphingomonadales	U	Oligogalacturonate lyase	-	-	4.2.2.6	ko:K01730	ko00040,map00040	-	R04382	RC02124,RC02427	ko00000,ko00001,ko01000	-	-	-	PD40,Pectate_lyase22
k59_1552040_2	1469607.KK073768_gene3804	4.38e-10	58.9	COG0386@1|root,COG0386@2|Bacteria,1G47I@1117|Cyanobacteria,1HN4V@1161|Nostocales	1117|Cyanobacteria	O	Belongs to the glutathione peroxidase family	btuE	-	1.11.1.22,1.11.1.9	ko:K00432,ko:K20207	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	iJN678.slr1171	GSHPx
k59_1786080_1	1193181.BN10_810010	5.99e-62	202.0	COG0407@1|root,COG0407@2|Bacteria,2GMY6@201174|Actinobacteria,4FFFP@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_1860006_1	697282.Mettu_3698	3.88e-74	233.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1XDZ4@135618|Methylococcales	135618|Methylococcales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_926237_2	1382306.JNIM01000001_gene118	2.07e-29	114.0	COG0343@1|root,COG0343@2|Bacteria,2G5RE@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k59_104279_1	1121033.AUCF01000020_gene668	1.63e-79	253.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,2JRK3@204441|Rhodospirillales	204441|Rhodospirillales	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N,Transketolase_C
k59_1731989_1	883126.HMPREF9710_03153	7.62e-15	70.5	COG3791@1|root,COG3791@2|Bacteria,1N6S5@1224|Proteobacteria,2WA8G@28216|Betaproteobacteria,4755A@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_1504138_1	301.JNHE01000025_gene2875	2.4e-87	271.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1YDWN@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008219,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0012501,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016779,GO:0019200,GO:0033692,GO:0033785,GO:0033786,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0070566,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.167,2.7.7.70	ko:K03272,ko:K21344	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iECH74115_1262.ECH74115_4363,iECSP_1301.ECSP_4025,iECs_1301.ECs3935,iPC815.YPO0654,iZ_1308.Z4405	CTP_transf_like,PfkB
k59_1865838_1	479434.Sthe_3026	6.54e-05	49.3	COG1309@1|root,COG1309@2|Bacteria,2G7DR@200795|Chloroflexi,27Y8Z@189775|Thermomicrobia	189775|Thermomicrobia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
k59_104309_1	270374.MELB17_22520	1.94e-18	86.3	COG5433@1|root,COG5433@2|Bacteria,1MY25@1224|Proteobacteria,1RMRM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_1337574_1	331678.Cphamn1_1230	2.46e-74	235.0	COG0226@1|root,COG0226@2|Bacteria	2|Bacteria	P	phosphate ion binding	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_147784_1	338969.Rfer_1050	5.43e-45	154.0	COG0702@1|root,COG0702@2|Bacteria,1N1C0@1224|Proteobacteria,2VT7I@28216|Betaproteobacteria	28216|Betaproteobacteria	GM	Complex I intermediate-associated protein 30	-	-	-	-	-	-	-	-	-	-	-	-	CIA30
k59_46495_2	1260251.SPISAL_05925	8.53e-28	111.0	COG4544@1|root,COG4544@2|Bacteria,1MZQU@1224|Proteobacteria,1S9RP@1236|Gammaproteobacteria,1WZQP@135613|Chromatiales	135613|Chromatiales	D	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division	-	-	-	ko:K14160	-	-	-	-	ko00000,ko03400	-	-	-	SulA
k59_1674657_1	1297742.A176_06102	1.67e-12	68.9	COG0596@1|root,COG0596@2|Bacteria,1R6KU@1224|Proteobacteria,438C4@68525|delta/epsilon subdivisions,2WYM4@28221|Deltaproteobacteria,2YWIJ@29|Myxococcales	28221|Deltaproteobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_1674657_2	1278073.MYSTI_07425	1.35e-72	225.0	COG4555@1|root,COG4555@2|Bacteria,1QU2T@1224|Proteobacteria,43BX9@68525|delta/epsilon subdivisions,2X782@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CP	ABC transporter	natA	-	3.6.3.7	ko:K09697	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.115	-	-	ABC_tran
k59_499435_1	1132855.KB913035_gene2292	5.39e-05	45.1	COG1999@1|root,COG1999@2|Bacteria,1N6R6@1224|Proteobacteria,2VXI0@28216|Betaproteobacteria,2KMZH@206350|Nitrosomonadales	206350|Nitrosomonadales	S	signal sequence binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_499435_2	1260251.SPISAL_01525	6.42e-57	188.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,1RQWB@1236|Gammaproteobacteria,1WZSA@135613|Chromatiales	135613|Chromatiales	O	cytochrome oxidase assembly	-	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
k59_1269768_1	1043493.BBLU01000002_gene1787	8.79e-82	251.0	COG1305@1|root,COG1305@2|Bacteria,2GN5D@201174|Actinobacteria	201174|Actinobacteria	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_851786_1	446469.Sked_15620	9.7e-54	181.0	COG1104@1|root,COG1104@2|Bacteria,2GJ2B@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the sulfur carrier protein TusA family	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5,TusA
k59_279460_1	518766.Rmar_1656	1.17e-70	236.0	COG0019@1|root,COG0527@1|root,COG0019@2|Bacteria,COG0527@2|Bacteria,4NFWR@976|Bacteroidetes,1FIKN@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Belongs to the Orn Lys Arg decarboxylase class-II family	-	-	2.7.2.4,4.1.1.20	ko:K00928,ko:K12526	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00451,R00480	RC00002,RC00043,RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_1269772_1	1304865.JAGF01000001_gene1676	5.41e-103	308.0	COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria,4F0DR@85016|Cellulomonadaceae	201174|Actinobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3708c	Semialdhyde_dh,Semialdhyde_dhC
k59_676867_1	1123518.ARWI01000001_gene1560	4.84e-94	285.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,4602Z@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_1023851_1	472759.Nhal_3055	2.52e-45	162.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RNES@1236|Gammaproteobacteria,1X2HE@135613|Chromatiales	135613|Chromatiales	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1380442_1	1384054.N790_11780	1.09e-78	248.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,1X3W9@135614|Xanthomonadales	135614|Xanthomonadales	M	Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A)	lpxL	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_788932_1	335543.Sfum_4022	3.33e-29	117.0	2DRBJ@1|root,32UQT@2|Bacteria,1NZ28@1224|Proteobacteria,430B9@68525|delta/epsilon subdivisions,2WVZQ@28221|Deltaproteobacteria,2MRY8@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_676869_1	247634.GPB2148_1770	1.01e-41	147.0	COG2207@1|root,COG2207@2|Bacteria,1R4MG@1224|Proteobacteria,1RQ8P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	AraC family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_676869_2	876044.IMCC3088_458	0.00061	41.2	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria	1224|Proteobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_927506_1	446469.Sked_08040	1.18e-72	239.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria	201174|Actinobacteria	P	Heavy metal translocating P-type atpase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K12954,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3,3.A.3.5	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
k59_1440489_1	1002340.AFCF01000068_gene2293	7.31e-54	179.0	COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,2TSS4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	catB	-	5.5.1.1	ko:K01856	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	M00568	R05300,R05390,R06989,R08116,R09229	RC00903,RC01038,RC01108,RC01321,RC01356	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_1440489_2	290400.Jann_1410	5.85e-13	68.2	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2TSQI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0665 Glycine D-amino acid oxidases (deaminating)	MA20_00655	-	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO
k59_986613_1	710685.MycrhN_0880	5.34e-80	264.0	COG1061@1|root,COG1112@1|root,COG1061@2|Bacteria,COG1112@2|Bacteria,2H3MV@201174|Actinobacteria,237MW@1762|Mycobacteriaceae	201174|Actinobacteria	KL	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,NERD,UvrD_C_2
k59_986613_2	590998.Celf_3615	6.37e-35	132.0	COG0477@1|root,COG2814@2|Bacteria,2GKMQ@201174|Actinobacteria,4F0M1@85016|Cellulomonadaceae	201174|Actinobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_676874_1	1122132.AQYH01000002_gene1283	1.9e-126	377.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria,4BAGU@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1142415_1	85643.Tmz1t_3039	1.96e-48	165.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,2VJEV@28216|Betaproteobacteria,2KUSW@206389|Rhodocyclales	206389|Rhodocyclales	E	chorismate mutase	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
k59_1142415_2	391615.ABSJ01000054_gene1432	5.32e-06	47.8	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1J5JV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Aminotransferase class I and II	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_735505_1	754476.Q7A_646	3.68e-32	124.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,45ZSX@72273|Thiotrichales	72273|Thiotrichales	NU	Type II IV secretion system protein	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
k59_735505_2	1249627.D779_1956	2.97e-21	93.6	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RNV0@1236|Gammaproteobacteria,1WWAB@135613|Chromatiales	135613|Chromatiales	U	Type II secretion system	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_280637_1	519989.ECTPHS_06822	4.54e-96	312.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1WXIK@135613|Chromatiales	135613|Chromatiales	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_1867104_2	395493.BegalDRAFT_2976	1.33e-52	176.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,1S3NR@1236|Gammaproteobacteria,46160@72273|Thiotrichales	72273|Thiotrichales	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
k59_148594_1	396588.Tgr7_2267	5.92e-87	270.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales	135613|Chromatiales	S	modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_1867110_1	1049564.TevJSym_an00780	4.7e-88	274.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,1T2DW@1236|Gammaproteobacteria,1J4QJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EQ	Hydantoinase B/oxoprolinase	hyuB	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_1732786_1	634497.HAH_4444	1.51e-117	369.0	COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,23SFC@183963|Halobacteria	183963|Halobacteria	P	Cation transporting ATPase, C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_735518_1	344747.PM8797T_10474	4.45e-102	306.0	COG0523@1|root,COG0523@2|Bacteria,2IXBH@203682|Planctomycetes	203682|Planctomycetes	S	PFAM cobalamin synthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
k59_788953_1	1035308.AQYY01000001_gene3484	5.5e-31	125.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,1TQJ2@1239|Firmicutes,248FW@186801|Clostridia,260ZS@186807|Peptococcaceae	186801|Clostridia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_47771_2	857087.Metme_3466	2.51e-21	85.9	COG1722@1|root,COG1722@2|Bacteria,1N72V@1224|Proteobacteria,1SC7N@1236|Gammaproteobacteria,1XFQ0@135618|Methylococcales	135618|Methylococcales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
k59_1505123_2	768671.ThimaDRAFT_3976	1e-31	117.0	COG0662@1|root,COG0662@2|Bacteria,1N00P@1224|Proteobacteria,1S759@1236|Gammaproteobacteria,1WYP8@135613|Chromatiales	135613|Chromatiales	G	PFAM Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_735522_1	156889.Mmc1_0519	5.46e-51	179.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TS80@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_500216_1	397945.Aave_2022	2.43e-41	156.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria,4ABG1@80864|Comamonadaceae	28216|Betaproteobacteria	G	SMART alpha amylase catalytic sub domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_441559_1	981369.JQMJ01000004_gene5876	1.65e-111	353.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,2NHKW@228398|Streptacidiphilus	201174|Actinobacteria	C	2-oxoglutarate dehydrogenase C-terminal	kgd	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1789769_1	1187851.A33M_1570	4.81e-61	201.0	COG0523@1|root,COG0523@2|Bacteria,1MY4T@1224|Proteobacteria,2U0DU@28211|Alphaproteobacteria,3FEAC@34008|Rhodovulum	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3623)	puhE	-	-	-	-	-	-	-	-	-	-	-	DUF3623
k59_1789769_2	1132836.RCCGE510_19273	5.63e-16	77.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQXI@28211|Alphaproteobacteria,4B9Z3@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	5-aminolevulinic acid synthase	hemA	-	2.3.1.37	ko:K00643	ko00260,ko00860,ko01100,ko01110,map00260,map00860,map01100,map01110	-	R00830	RC00004,RC02815	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_399192_1	686340.Metal_1461	4.8e-88	273.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1XEMS@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_927584_1	1121374.KB891576_gene732	1.55e-34	136.0	COG5148@1|root,COG5148@2|Bacteria,1QTZE@1224|Proteobacteria,1RY3H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Protein of unknown function (DUF1631)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631
k59_676920_1	1121405.dsmv_3215	1.57e-53	185.0	COG1032@1|root,COG1032@2|Bacteria,1R52J@1224|Proteobacteria,42P9G@68525|delta/epsilon subdivisions,2WKFU@28221|Deltaproteobacteria,2MIVS@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_1096411_1	880072.Desac_0855	4.52e-63	196.0	COG1259@1|root,COG1259@2|Bacteria,1RFFV@1224|Proteobacteria,42SCI@68525|delta/epsilon subdivisions,2WPWT@28221|Deltaproteobacteria,2MQHM@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
k59_441564_1	370438.PTH_0462	1.07e-80	246.0	COG0410@1|root,COG0410@2|Bacteria,1U9ET@1239|Firmicutes,249MH@186801|Clostridia,260RJ@186807|Peptococcaceae	186801|Clostridia	E	PFAM ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_1023902_1	869213.JCM21142_83147	3.04e-21	95.9	COG0679@1|root,COG0679@2|Bacteria,4NX5F@976|Bacteroidetes	976|Bacteroidetes	S	auxin efflux carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
k59_1732818_1	1380354.JIAN01000005_gene2705	1.89e-25	108.0	COG1190@1|root,COG2898@1|root,COG1190@2|Bacteria,COG2898@2|Bacteria,2GKE0@201174|Actinobacteria,4F1Q9@85016|Cellulomonadaceae	201174|Actinobacteria	J	Uncharacterised conserved protein (DUF2156)	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DUF2156,tRNA-synt_2,tRNA-synt_2_TM,tRNA_anti-codon
k59_1614568_1	626887.J057_05721	3.31e-45	153.0	COG3639@1|root,COG3639@2|Bacteria,1MW4F@1224|Proteobacteria,1RSR1@1236|Gammaproteobacteria,46AGM@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
k59_1614568_2	167548.EU98_0457	1.24e-12	68.2	COG3639@1|root,COG3639@2|Bacteria,1G482@1117|Cyanobacteria,1MKQ9@1212|Prochloraceae	1117|Cyanobacteria	P	organic phosphonate transmembrane transporter activity	-	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
k59_1440550_1	1122622.ATWJ01000013_gene40	1.33e-86	267.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4FIFZ@85021|Intrasporangiaceae	201174|Actinobacteria	M	DegT/DnrJ/EryC1/StrS aminotransferase family	degT	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
k59_1023909_1	1123279.ATUS01000001_gene2578	3.73e-18	88.6	COG0451@1|root,COG0451@2|Bacteria,1P603@1224|Proteobacteria,1RQ2R@1236|Gammaproteobacteria,1J6J5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_986736_1	765911.Thivi_3299	2.74e-156	456.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,1RZ0U@1236|Gammaproteobacteria,1WW7B@135613|Chromatiales	135613|Chromatiales	C	reductase, alpha subunit	-	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
k59_986736_2	765911.Thivi_3300	1.9e-32	115.0	COG1146@1|root,COG1146@2|Bacteria,1RC9N@1224|Proteobacteria,1S3TG@1236|Gammaproteobacteria,1X27P@135613|Chromatiales	135613|Chromatiales	C	Adenosine-5'-phosphosulfate reductase beta subunit	-	-	1.8.99.2	ko:K00395	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	APS-reductase_C,Fer4_9
k59_1556390_1	367299.JOEE01000004_gene1099	6.67e-113	332.0	COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria,4FEYA@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_986744_1	794903.OPIT5_11255	8.05e-52	180.0	COG0012@1|root,COG0012@2|Bacteria,46UY8@74201|Verrucomicrobia	74201|Verrucomicrobia	J	GTP binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1142486_1	572477.Alvin_2079	1.98e-30	118.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales	135613|Chromatiales	P	PFAM TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_1440570_1	913325.N799_02530	1.95e-25	105.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,1RNPS@1236|Gammaproteobacteria,1X4B4@135614|Xanthomonadales	135614|Xanthomonadales	M	Lipoprotein	-	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
k59_1440570_2	381666.H16_A3425	7.22e-60	190.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,2VRKR@28216|Betaproteobacteria,1K3MD@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	mlaD	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_1270827_1	246200.SPO0710	6.61e-50	164.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2TR43@28211|Alphaproteobacteria,4NATY@97050|Ruegeria	28211|Alphaproteobacteria	K	Transcriptional regulatory protein, C terminal	chvI	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K14981	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1023927_2	1463879.JOHP01000032_gene5280	4.58e-19	89.7	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria	201174|Actinobacteria	NU	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_735584_1	522772.Dacet_2940	9.36e-16	72.4	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	-	-	3.6.1.17	ko:K01518,ko:K08296	ko00230,ko00240,map00230,map00240	-	R00184,R00969,R01232,R02805	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_735584_2	156889.Mmc1_0229	2.83e-135	395.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2TSYI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Phosphate	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_1556407_1	335543.Sfum_1954	2.06e-87	282.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,42PT5@68525|delta/epsilon subdivisions,2WIPN@28221|Deltaproteobacteria,2MR73@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM NADH-quinone oxidoreductase, chain G	nuoG-2	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1789813_1	1123065.ATWL01000006_gene2298	1.27e-84	263.0	COG0015@1|root,COG0015@2|Bacteria,2GM71@201174|Actinobacteria	201174|Actinobacteria	F	Adenylosuccinate lyase	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
k59_1270838_1	1211115.ALIQ01000181_gene1544	1.02e-56	194.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2TU0W@28211|Alphaproteobacteria,3NA54@45404|Beijerinckiaceae	28211|Alphaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_D23
k59_1339018_2	1265505.ATUG01000001_gene2918	2.68e-67	209.0	COG4871@1|root,COG4871@2|Bacteria,1RF0E@1224|Proteobacteria,42RKU@68525|delta/epsilon subdivisions,2WNHT@28221|Deltaproteobacteria,2MK4I@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Putative Fe-S cluster	-	-	-	-	-	-	-	-	-	-	-	-	FeS
k59_1387368_1	118163.Ple7327_1609	2.26e-40	145.0	COG0430@1|root,COG0430@2|Bacteria,1G3A2@1117|Cyanobacteria	1117|Cyanobacteria	A	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	-	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
k59_1349373_2	1463855.JOHV01000019_gene668	1.1e-16	82.8	COG1597@1|root,COG1597@2|Bacteria,2GK3P@201174|Actinobacteria	201174|Actinobacteria	I	Diacylglycerol kinase	-	-	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_cat
k59_1563162_1	420662.Mpe_A1640	1.4e-58	202.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,1KJVH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	heavy metal translocating P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_57276_1	1211114.ALIP01000081_gene2507	2.85e-30	120.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1X3EN@135614|Xanthomonadales	135614|Xanthomonadales	O	Belongs to the peptidase S1C family	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
k59_624267_1	517417.Cpar_0413	1.54e-86	265.0	COG3588@1|root,COG3588@2|Bacteria,1FEFW@1090|Chlorobi	1090|Chlorobi	G	PFAM fructose-bisphosphate aldolase class-I	-	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
k59_794460_1	765911.Thivi_3689	1.18e-09	58.9	COG3437@1|root,COG3437@2|Bacteria,1QUN9@1224|Proteobacteria,1S0ZZ@1236|Gammaproteobacteria,1WX12@135613|Chromatiales	135613|Chromatiales	KT	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	PAS,PAS_9,Response_reg
k59_794460_3	1198232.CYCME_2433	5.91e-08	49.7	2DDNE@1|root,2ZINX@2|Bacteria,1PAK4@1224|Proteobacteria,1STKN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1031012_1	391037.Sare_3213	1.86e-36	139.0	COG1835@1|root,COG1835@2|Bacteria,2GN56@201174|Actinobacteria,4DC3S@85008|Micromonosporales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_448451_1	987059.RBXJA2T_09182	5.08e-90	275.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,1KJ8Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	DDE_Tnp_ISL3,FA_desaturase
k59_1349389_1	1384054.N790_12830	3.93e-49	162.0	COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,1RNSJ@1236|Gammaproteobacteria,1X6DN@135614|Xanthomonadales	135614|Xanthomonadales	C	Part of a membrane complex involved in electron transport	ydgM	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4_21
k59_507133_1	1121439.dsat_0367	8.74e-83	269.0	COG3850@1|root,COG4191@1|root,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WJKV@28221|Deltaproteobacteria,2M7VM@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K02482,ko:K10819	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9
k59_155776_1	1121123.AUAO01000002_gene114	2.89e-18	85.5	COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2TVJ7@28211|Alphaproteobacteria,2KGJV@204458|Caulobacterales	204458|Caulobacterales	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
k59_1278420_1	713586.KB900536_gene2967	6.32e-103	323.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales	135613|Chromatiales	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HTH_12,OB_RNB,RNB,S1
k59_937672_1	1046724.KB889906_gene869	1.29e-59	193.0	COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,1RQ6C@1236|Gammaproteobacteria,46D51@72275|Alteromonadaceae	1236|Gammaproteobacteria	HP	COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_1563175_1	717785.HYPMC_0767	1.43e-80	261.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,3N69H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	NU	ErfK YbiS YcfS YnhG family protein	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_448455_1	404589.Anae109_1909	5.36e-160	472.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria,2YUNN@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_565693_1	1005048.CFU_3615	8.79e-30	122.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2VH1I@28216|Betaproteobacteria,472BF@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_565693_2	224324.aq_101	0.00089	42.4	COG1253@1|root,COG1253@2|Bacteria,2G3YI@200783|Aquificae	200783|Aquificae	S	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1739836_1	63737.Npun_R0589	2.81e-131	392.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1FZX5@1117|Cyanobacteria,1HMXM@1161|Nostocales	1117|Cyanobacteria	KOT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Response_reg
k59_448456_2	1042377.AFPJ01000004_gene336	2.35e-16	84.0	COG0845@1|root,COG0845@2|Bacteria,1R99C@1224|Proteobacteria,1RZS0@1236|Gammaproteobacteria,46C8U@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1031031_1	743299.Acife_3108	5.71e-73	236.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,1RWK9@1236|Gammaproteobacteria,2NBVK@225057|Acidithiobacillales	225057|Acidithiobacillales	L	DNA polymerase	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
k59_565704_1	582899.Hden_0688	6.62e-75	226.0	COG2044@1|root,COG2044@2|Bacteria,1RGWS@1224|Proteobacteria,2UB97@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
k59_565704_2	582899.Hden_0689	9.26e-20	85.5	COG1150@1|root,COG1150@2|Bacteria,1R7PH@1224|Proteobacteria,2U2FE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
k59_1349428_1	1151122.AQYD01000007_gene665	3.33e-65	230.0	COG2911@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG4625@1|root,COG4932@1|root,COG5373@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,COG4625@2|Bacteria,COG4932@2|Bacteria,COG5373@2|Bacteria	2|Bacteria	KLT	membrane	-	-	-	ko:K02451,ko:K03832,ko:K13735,ko:K20276,ko:K21449	ko02024,ko05100,map02024,map05100	M00331	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	1.B.40.2,2.C.1.1,9.B.42	-	-	PATR,T2SSB
k59_996981_1	358823.DF19_31700	1.7e-73	238.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria	201174|Actinobacteria	G	alpha amylase, catalytic	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_1148681_1	1049564.TevJSym_ca00050	7.53e-46	167.0	COG1033@1|root,COG2834@1|root,COG1033@2|Bacteria,COG2834@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1J96Q@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	MMPL family	VP1286	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_1148681_2	243159.AFE_2209	2.35e-18	82.4	COG1309@1|root,COG1309@2|Bacteria,1RGCX@1224|Proteobacteria,1S8SN@1236|Gammaproteobacteria,2NCD9@225057|Acidithiobacillales	225057|Acidithiobacillales	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_13,TetR_N
k59_624303_1	767029.HMPREF9154_0546	2.27e-33	130.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria,2GKDT@201174|Actinobacteria,4DPGX@85009|Propionibacteriales	201174|Actinobacteria	CO	Thioredoxin-like	dipZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD
k59_116054_1	644283.Micau_0772	3.56e-81	260.0	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria,4D8KC@85008|Micromonosporales	201174|Actinobacteria	G	Alpha-amylase domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_155807_1	1121405.dsmv_3570	1.17e-100	304.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2WIZ7@28221|Deltaproteobacteria,2MHM9@213118|Desulfobacterales	28221|Deltaproteobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_1739867_1	1267005.KB911259_gene3893	2.03e-118	343.0	COG1692@1|root,COG1692@2|Bacteria,1MW12@1224|Proteobacteria,2TS4S@28211|Alphaproteobacteria,3N67E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	YmdB-like protein	MA20_17970	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
k59_1563202_1	680646.RMDY18_03780	7.49e-59	191.0	COG0765@1|root,COG0765@2|Bacteria,2GM0I@201174|Actinobacteria,1W7G1@1268|Micrococcaceae	201174|Actinobacteria	E	ABC transporter permease	-	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
k59_1563202_2	1394178.AWOO02000053_gene8131	1.5e-129	374.0	COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria,4EHMV@85012|Streptosporangiales	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	glnQ	-	3.6.3.21	ko:K02028,ko:K17076	ko02010,map02010	M00236,M00589	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.20	-	-	ABC_tran
k59_331589_1	266264.Rmet_1537	3.52e-55	195.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,2VHS4@28216|Betaproteobacteria,1K2HP@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	hypF2	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Carbam_trans_N,Sua5_yciO_yrdC,zf-HYPF
k59_996997_1	1249627.D779_0211	2.47e-80	255.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,1WWWJ@135613|Chromatiales	135613|Chromatiales	O	HflC and HflK could encode or regulate a protease	-	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
k59_996997_2	1286106.MPL1_04160	9.21e-23	96.7	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,460B4@72273|Thiotrichales	72273|Thiotrichales	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_1512664_1	498211.CJA_3566	3.05e-83	268.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1FG8D@10|Cellvibrio	1236|Gammaproteobacteria	L	UvrD-like helicase C-terminal domain	uvrD	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0042802,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_155819_1	1280944.HY17_18360	2.28e-16	80.5	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_8,Trans_reg_C
k59_1104016_1	335543.Sfum_4041	8.43e-27	99.4	2DS67@1|root,33ER5@2|Bacteria,1R3JK@1224|Proteobacteria,43DKG@68525|delta/epsilon subdivisions,2X8RN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Dissimilatory sulfite reductase D	-	-	-	-	-	-	-	-	-	-	-	-	DsrD
k59_290017_1	1249627.D779_4166	8.54e-92	286.0	COG0465@1|root,COG0465@2|Bacteria,1R8MI@1224|Proteobacteria,1S1C9@1236|Gammaproteobacteria,1WW99@135613|Chromatiales	135613|Chromatiales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_742731_1	1121447.JONL01000010_gene2406	7.84e-07	51.6	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,42MHR@68525|delta/epsilon subdivisions,2WIY8@28221|Deltaproteobacteria,2M86G@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_794508_1	933262.AXAM01000020_gene23	4.62e-115	346.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2WJCI@28221|Deltaproteobacteria,2MHS8@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_1349461_1	1123401.JHYQ01000027_gene3134	3.23e-122	356.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria,4608T@72273|Thiotrichales	72273|Thiotrichales	E	TIGRFAM Serine O-acetyltransferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
k59_291279_1	1449351.RISW2_17380	2.57e-41	140.0	COG1238@1|root,COG1238@2|Bacteria,1RHUV@1224|Proteobacteria,2U9F7@28211|Alphaproteobacteria,4KMQQ@93682|Roseivivax	28211|Alphaproteobacteria	S	SNARE associated Golgi protein	yqaA	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_1279393_1	247639.MGP2080_05657	2.61e-50	172.0	COG1196@1|root,COG1196@2|Bacteria,1R4BS@1224|Proteobacteria,1S13B@1236|Gammaproteobacteria,1J7UD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	von Willebrand factor (VWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_117239_1	713587.THITH_00810	8.03e-118	340.0	COG0599@1|root,COG2146@1|root,COG0599@2|Bacteria,COG2146@2|Bacteria,1RCCG@1224|Proteobacteria	1224|Proteobacteria	P	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD,Rieske
k59_1032002_1	1384054.N790_04050	1.59e-115	339.0	COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,1RN27@1236|Gammaproteobacteria,1X3E4@135614|Xanthomonadales	135614|Xanthomonadales	S	Zn-dependent hydrolases including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_938939_1	269797.Mbar_A1663	4.29e-144	418.0	COG1228@1|root,arCOG00696@2157|Archaea,2XWAY@28890|Euryarchaeota	28890|Euryarchaeota	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_743552_1	314278.NB231_06950	1.65e-12	69.7	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WW5M@135613|Chromatiales	135613|Chromatiales	EH	Anthranilate synthase component I	-	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_625225_2	631362.Thi970DRAFT_03030	3.19e-32	126.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,1RPDC@1236|Gammaproteobacteria,1WWR8@135613|Chromatiales	135613|Chromatiales	S	PFAM Bacterial domain of	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
k59_291292_1	472759.Nhal_0923	8.95e-38	134.0	COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1WX1P@135613|Chromatiales	135613|Chromatiales	S	Cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
k59_291292_2	472759.Nhal_0922	3.44e-49	169.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1WWQM@135613|Chromatiales	135613|Chromatiales	P	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1796623_1	10224.XP_006819348.1	2.31e-96	313.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F2S@33154|Opisthokonta,3BI3C@33208|Metazoa,3D3YU@33213|Bilateria	33208|Metazoa	L	Gypsy retrotransposon	GIN1	-	-	-	-	-	-	-	-	-	-	-	rve,zf-CCHC,zf-H2C2
k59_1683002_1	765910.MARPU_01690	1.82e-84	263.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1WVZD@135613|Chromatiales	135613|Chromatiales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_1622190_1	1151122.AQYD01000007_gene665	5.2e-42	160.0	COG2911@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG4625@1|root,COG4932@1|root,COG5373@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,COG4625@2|Bacteria,COG4932@2|Bacteria,COG5373@2|Bacteria	2|Bacteria	KLT	membrane	-	-	-	ko:K02451,ko:K03832,ko:K13735,ko:K20276,ko:K21449	ko02024,ko05100,map02024,map05100	M00331	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	1.B.40.2,2.C.1.1,9.B.42	-	-	PATR,T2SSB
k59_795167_1	446469.Sked_14110	5.5e-05	45.1	COG0331@1|root,COG0331@2|Bacteria,2GME0@201174|Actinobacteria	201174|Actinobacteria	I	PFAM Acyl transferase	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005835,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
k59_795167_2	935839.JAGJ01000035_gene149	6.62e-134	388.0	COG0332@1|root,COG0332@2|Bacteria,2GJP8@201174|Actinobacteria,4F44I@85017|Promicromonosporaceae	201174|Actinobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005488,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017076,GO:0019637,GO:0019693,GO:0019752,GO:0030497,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033818,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035336,GO:0035337,GO:0035383,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901567,GO:1901568,GO:1901576,GO:1901681	2.3.1.180	ko:K00648,ko:K11608	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iNJ661.Rv0533c	ACP_syn_III,ACP_syn_III_C
k59_1740772_1	697282.Mettu_0405	2.3e-89	289.0	COG3459@1|root,COG3459@2|Bacteria,1R1HB@1224|Proteobacteria,1T531@1236|Gammaproteobacteria,1XG0G@135618|Methylococcales	135618|Methylococcales	G	Glycosyltransferase 36 associated	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1622197_1	1267005.KB911260_gene3554	1.17e-112	347.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,3N6J9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1513589_1	768671.ThimaDRAFT_2884	1.58e-59	217.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1WXN6@135613|Chromatiales	135613|Chromatiales	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_1564018_1	1502724.FF80_00161	3.34e-10	57.0	COG2261@1|root,COG2261@2|Bacteria,1N6QR@1224|Proteobacteria,2UFTV@28211|Alphaproteobacteria,3N9DM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
k59_1564018_2	1502851.FG93_06187	1.46e-31	112.0	COG2261@1|root,COG2261@2|Bacteria,1N6QR@1224|Proteobacteria,2UFTV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
k59_743571_1	926550.CLDAP_07620	2.56e-67	230.0	COG0236@1|root,COG0304@1|root,COG1028@1|root,COG3321@1|root,COG0236@2|Bacteria,COG0304@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,2G68I@200795|Chloroflexi	200795|Chloroflexi	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	-	ko:K15314	ko01059,ko01130,map01059,map01130	M00824,M00825	R11435	-	ko00000,ko00001,ko00002,ko01008	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
k59_795171_1	396588.Tgr7_3057	2.14e-190	549.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales	135613|Chromatiales	I	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_291329_1	243233.MCA1979	3.53e-50	173.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1XE8R@135618|Methylococcales	135618|Methylococcales	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
k59_1104989_1	979556.MTES_0128	1.38e-22	97.4	COG2372@1|root,COG2372@2|Bacteria,2GMKG@201174|Actinobacteria,4FQ1N@85023|Microbacteriaceae	201174|Actinobacteria	S	CopC domain	-	-	-	ko:K07156,ko:K14166	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	CopC,CopD
k59_743580_1	439235.Dalk_0920	9.11e-62	197.0	29GM5@1|root,303IT@2|Bacteria,1RG3T@1224|Proteobacteria,42RUX@68525|delta/epsilon subdivisions,2WNMJ@28221|Deltaproteobacteria,2MJY1@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4390)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4390
k59_291346_1	857087.Metme_3943	6.47e-103	310.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1XDXR@135618|Methylococcales	135618|Methylococcales	J	PFAM Aminoacyl-tRNA synthetase, class II (G H P S), conserved region	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_860007_1	313589.JNB_17553	5.52e-63	209.0	COG0477@1|root,COG2814@2|Bacteria,2GIZX@201174|Actinobacteria,4FEY4@85021|Intrasporangiaceae	201174|Actinobacteria	U	the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_860007_2	367299.JOEE01000007_gene108	2.29e-43	150.0	COG3191@1|root,COG3191@2|Bacteria,2GJKQ@201174|Actinobacteria,4FE8D@85021|Intrasporangiaceae	201174|Actinobacteria	EQ	Peptidase family S58	dmpA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
k59_625269_2	491952.Mar181_0012	3.85e-66	216.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1XHSI@135619|Oceanospirillales	135619|Oceanospirillales	P	Trk system potassium uptake protein	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_117305_1	1123366.TH3_00385	3.94e-42	148.0	COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,2TR8G@28211|Alphaproteobacteria,2JPDD@204441|Rhodospirillales	204441|Rhodospirillales	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
k59_117305_2	1313301.AUGC01000009_gene1058	4.95e-44	152.0	COG0451@1|root,COG0451@2|Bacteria,4NDV4@976|Bacteroidetes	976|Bacteroidetes	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
k59_332492_1	1121952.ATXT01000018_gene1942	2.97e-06	48.5	COG0055@1|root,COG0055@2|Bacteria,2GIY6@201174|Actinobacteria,4FMEM@85023|Microbacteriaceae	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_332492_2	1288083.AUKR01000002_gene4549	1.56e-104	314.0	COG0224@1|root,COG0224@2|Bacteria,2GJ7Q@201174|Actinobacteria	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_156672_1	1177181.T9A_00575	2.22e-60	207.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1XHCM@135619|Oceanospirillales	135619|Oceanospirillales	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_1740808_1	1288494.EBAPG3_28930	2.57e-49	171.0	COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,2VNEP@28216|Betaproteobacteria	28216|Betaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1149481_2	467661.RKLH11_3053	2.52e-21	95.5	COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2TSX2@28211|Alphaproteobacteria,3ZG83@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	O	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
k59_625281_1	1333998.M2A_2450	2.27e-69	216.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2U5P0@28211|Alphaproteobacteria,4BQBF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_1513634_1	629773.AORY01000012_gene959	1.83e-73	239.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,2K0PZ@204457|Sphingomonadales	204457|Sphingomonadales	E	gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1448058_1	553385.JEMF01000023_gene3213	5.86e-32	129.0	COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1S3Q4@1236|Gammaproteobacteria,1XK3E@135619|Oceanospirillales	135619|Oceanospirillales	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_1740821_1	551275.KB899544_gene955	9.7e-06	50.1	COG2850@1|root,COG2850@2|Bacteria,1MUAC@1224|Proteobacteria,2TSG2@28211|Alphaproteobacteria,43XJV@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	A domain family that is part of the cupin metalloenzyme superfamily.	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_8
k59_1740821_2	314287.GB2207_03409	4.78e-20	87.0	COG1262@1|root,COG1262@2|Bacteria,1RB2U@1224|Proteobacteria,1T3VJ@1236|Gammaproteobacteria,1JAMK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	SapC	-	-	-	-	-	-	-	-	-	-	-	-	SapC
k59_449396_1	1134474.O59_003363	2.59e-21	92.8	COG1075@1|root,COG1075@2|Bacteria,1N2W0@1224|Proteobacteria,1S2JW@1236|Gammaproteobacteria,1FH0W@10|Cellvibrio	1236|Gammaproteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,DUF676,Hydrolase_4,PGAP1
k59_1572985_2	999541.bgla_1g15210	3.58e-38	135.0	COG4566@1|root,COG4566@2|Bacteria,1RBBQ@1224|Proteobacteria,2VRAR@28216|Betaproteobacteria,1K2DR@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_869523_1	367299.JOEE01000001_gene2052	1.81e-85	263.0	COG1905@1|root,COG1905@2|Bacteria,2GKG0@201174|Actinobacteria,4FFA6@85021|Intrasporangiaceae	201174|Actinobacteria	C	NADH dehydrogenase subunit E	nuoE	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_1457146_1	590998.Celf_2311	3.21e-116	353.0	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria	201174|Actinobacteria	G	alpha amylase, catalytic	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_165282_1	1169143.KB911035_gene2475	3.59e-14	73.2	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,1K24M@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_D23
k59_165282_2	1038869.AXAN01000022_gene1925	1.78e-72	243.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1K0FI@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Efflux pump membrane transporter	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1396749_1	765913.ThidrDRAFT_0738	1.61e-42	144.0	COG4319@1|root,COG4319@2|Bacteria,1NEUY@1224|Proteobacteria,1S6AP@1236|Gammaproteobacteria,1WYK1@135613|Chromatiales	135613|Chromatiales	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
k59_1396749_2	187272.Mlg_1805	8.65e-11	62.4	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,1WWPU@135613|Chromatiales	135613|Chromatiales	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_752264_1	479431.Namu_0309	2.81e-57	199.0	COG1080@1|root,COG1925@1|root,COG2190@1|root,COG1080@2|Bacteria,COG1925@2|Bacteria,COG2190@2|Bacteria,2GIZZ@201174|Actinobacteria,4ERGZ@85013|Frankiales	201174|Actinobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.1.202,2.7.3.9	ko:K02768,ko:K08483,ko:K11183	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PPDK_N,PTS-HPr,PTS_EIIA_1
k59_223417_1	156889.Mmc1_3432	6.22e-79	242.0	COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria	1224|Proteobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
k59_165292_1	1121448.DGI_0699	3.34e-62	196.0	COG0778@1|root,COG0778@2|Bacteria,1RBBW@1224|Proteobacteria,42QWC@68525|delta/epsilon subdivisions,2WMVU@28221|Deltaproteobacteria,2MBJK@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_1631163_1	1235457.C404_09730	1.6e-111	333.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2VHJY@28216|Betaproteobacteria,1JZYC@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_574415_1	1120999.JONM01000001_gene1273	3.68e-36	134.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VH55@28216|Betaproteobacteria,2KPJJ@206351|Neisseriales	206351|Neisseriales	E	amino acid ABC transporter	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_574415_2	999541.bgla_1g32010	4.71e-15	73.6	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2VJAS@28216|Betaproteobacteria,1JZRY@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1457162_1	864051.BurJ1DRAFT_0325	1.3e-35	137.0	COG2270@1|root,COG2270@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K08162,ko:K08226,ko:K16211	-	-	-	-	ko00000,ko02000	2.A.1.2.21,2.A.1.41,2.A.2.6	-	-	MFS_1,PUCC
k59_223423_1	314278.NB231_11929	4.95e-37	139.0	COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,1RT8G@1236|Gammaproteobacteria,1WYZM@135613|Chromatiales	135613|Chromatiales	T	signal transduction protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
k59_574428_1	1121423.JONT01000004_gene1588	8.72e-45	159.0	COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,260T7@186807|Peptococcaceae	186801|Clostridia	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_869564_2	1537994.JQFW01000015_gene1561	1.79e-05	48.9	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1RPR0@1236|Gammaproteobacteria,4646A@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG2199 FOG GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_4
k59_223442_2	1123401.JHYQ01000029_gene1956	4.79e-100	297.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,4606Q@72273|Thiotrichales	72273|Thiotrichales	L	Exodeoxyribonuclease III xth	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_1457188_2	555779.Dthio_PD2875	5.58e-83	257.0	COG1228@1|root,COG1228@2|Bacteria,1MXXR@1224|Proteobacteria,42ND4@68525|delta/epsilon subdivisions,2WKQP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_1573045_1	693977.Deipr_0721	2.23e-33	133.0	COG2074@1|root,COG2074@2|Bacteria,1WI2U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	2-phosphoglycerate kinase	-	-	-	ko:K05715	-	-	R02664	RC00002,RC00017	ko00000,ko01000	-	-	-	ATP-cone
k59_1573045_2	243365.CV_0156	1.45e-12	64.3	COG2954@1|root,COG2954@2|Bacteria,1RI38@1224|Proteobacteria,2VRB9@28216|Betaproteobacteria,2KR2X@206351|Neisseriales	206351|Neisseriales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CYTH
k59_633519_1	641491.DND132_0347	4.98e-60	194.0	COG0765@1|root,COG0765@2|Bacteria,1MX3E@1224|Proteobacteria,42MFY@68525|delta/epsilon subdivisions,2WJS5@28221|Deltaproteobacteria,2M877@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	polar amino acid ABC transporter, inner membrane subunit	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
k59_869586_1	1380393.JHVP01000004_gene387	8.33e-41	152.0	28HJF@1|root,2Z7UK@2|Bacteria,2ICK7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1290442_1	1415780.JPOG01000001_gene2435	1.84e-18	85.5	COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria,1X66I@135614|Xanthomonadales	135614|Xanthomonadales	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
k59_1396807_1	1232437.KL661971_gene4888	5.3e-89	286.0	COG0067@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0070@2|Bacteria,1NZ4D@1224|Proteobacteria,43B3T@68525|delta/epsilon subdivisions,2X6HR@28221|Deltaproteobacteria,2MN6R@213118|Desulfobacterales	28221|Deltaproteobacteria	E	GXGXG motif	-	-	-	-	-	-	-	-	-	-	-	-	GATase_6,GXGXG
k59_1524495_1	565045.NOR51B_2076	1.5e-57	188.0	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria,1J5TZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	COG0501 Zn-dependent protease with chaperone function	Z012_09445	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_574459_1	768671.ThimaDRAFT_0873	1.01e-52	183.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGB@1236|Gammaproteobacteria,1X1MI@135613|Chromatiales	135613|Chromatiales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_515575_1	1198452.Jab_2c08630	4.78e-53	180.0	COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,2VNBH@28216|Betaproteobacteria,476U3@75682|Oxalobacteraceae	1224|Proteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_1221829_2	589865.DaAHT2_2376	9.72e-38	141.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,42MWM@68525|delta/epsilon subdivisions,2WK3H@28221|Deltaproteobacteria,2MJGB@213118|Desulfobacterales	28221|Deltaproteobacteria	O	NfeD-like C-terminal, partner-binding	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD,SDH_sah
k59_1156953_1	883.DvMF_0822	3.9e-94	292.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2WJVZ@28221|Deltaproteobacteria,2M885@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	elongation factor Tu domain 2 protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_165366_1	2074.JNYD01000002_gene5620	8.79e-102	313.0	COG3243@1|root,COG3243@2|Bacteria,2GNYP@201174|Actinobacteria,4E13S@85010|Pseudonocardiales	201174|Actinobacteria	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
k59_1803879_1	749927.AMED_3835	4.47e-28	113.0	COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,4DYUC@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM CoA-transferase family III	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
k59_1803879_2	1192034.CAP_1263	1.39e-09	59.7	COG1024@1|root,COG1024@2|Bacteria,1Q67Q@1224|Proteobacteria,42SEY@68525|delta/epsilon subdivisions,2WPN4@28221|Deltaproteobacteria,2YV2J@29|Myxococcales	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_1156955_2	521011.Mpal_0807	1.11e-06	53.5	arCOG09451@1|root,arCOG09451@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1524514_1	177439.DP1202	9.69e-118	353.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,2MHX9@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_1290479_1	1129794.C427_2779	6.73e-85	287.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D9@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	mdtB	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_752355_1	55529.EKX32325	2.05e-17	87.0	2CJ4S@1|root,2SCW9@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_341241_1	479435.Kfla_2885	7.76e-122	364.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4DNTV@85009|Propionibacteriales	201174|Actinobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2155c	AlaDh_PNT_C,Mur_ligase_C,Mur_ligase_M
k59_1042196_1	1429046.RR21198_3551	1.38e-87	278.0	COG3385@1|root,COG3385@2|Bacteria,2H68X@201174|Actinobacteria,4FXGX@85025|Nocardiaceae	201174|Actinobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_1042201_1	371731.Rsw2DRAFT_1609	8.8e-15	70.9	COG3453@1|root,COG3453@2|Bacteria,1N9AF@1224|Proteobacteria,2UD2M@28211|Alphaproteobacteria,1FC4U@1060|Rhodobacter	28211|Alphaproteobacteria	S	Putative phosphatase (DUF442)	blh	-	-	-	-	-	-	-	-	-	-	-	DUF442
k59_1042201_2	1123504.JQKD01000030_gene4639	5.73e-07	50.8	COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria,2VY9Z@28216|Betaproteobacteria,4AFU1@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM zinc finger, DksA TraR C4-type	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
k59_574484_1	666685.R2APBS1_2243	2.02e-52	184.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1X486@135614|Xanthomonadales	135614|Xanthomonadales	I	3-hydroxyacyl-coa dehydrogenase	fadJ	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_223510_1	1121875.KB907560_gene526	3.9e-06	52.0	2DNPH@1|root,32YF1@2|Bacteria,4NVUP@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1524540_1	96561.Dole_1635	4.07e-56	178.0	COG3005@1|root,COG3005@2|Bacteria,1RIC0@1224|Proteobacteria,42NW0@68525|delta/epsilon subdivisions,2WK0R@28221|Deltaproteobacteria,2MJCY@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM NapC NirT cytochrome c	-	-	-	ko:K02569,ko:K03532	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	5.A.3.4	-	-	Cytochrom_NNT
k59_1524540_2	880072.Desac_1709	3.1e-15	74.7	COG1309@1|root,COG1309@2|Bacteria,1ND26@1224|Proteobacteria,43EW9@68525|delta/epsilon subdivisions,2X29Y@28221|Deltaproteobacteria,2MSD6@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	YsiA-like protein, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4
k59_1290499_2	870187.Thini_3392	4.75e-94	296.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,45ZR1@72273|Thiotrichales	72273|Thiotrichales	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_869650_1	67356.KL575594_gene4695	3.42e-33	123.0	COG2197@1|root,COG2197@2|Bacteria,2GJKM@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_869650_2	335543.Sfum_3211	3.23e-05	46.2	COG3437@1|root,COG4585@1|root,COG3437@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,42RUN@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS,PAS_9
k59_693107_1	768671.ThimaDRAFT_0763	1.39e-30	114.0	COG1034@1|root,COG1034@2|Bacteria,1QVC7@1224|Proteobacteria	1224|Proteobacteria	C	NADH ubiquinone oxidoreductase	hoxU	-	1.12.1.2	ko:K18006	-	-	-	-	ko00000,ko01000	-	-	-	Fer2_4,Fer4_15,NADH-G_4Fe-4S_3
k59_693107_2	768671.ThimaDRAFT_0762	3.42e-83	265.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1WY5M@135613|Chromatiales	135613|Chromatiales	C	NADH ubiquinone oxidoreductase	-	-	1.17.1.9	ko:K00122	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_1290507_2	857087.Metme_0702	1.63e-56	186.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1XDSG@135618|Methylococcales	135618|Methylococcales	M	Arabinose 5-phosphate isomerase	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
k59_869660_1	935839.JAGJ01000003_gene1394	2.61e-123	370.0	COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria,4F36H@85017|Promicromonosporaceae	201174|Actinobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_752388_1	765912.Thimo_0389	1.21e-110	330.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,1WWRH@135613|Chromatiales	1236|Gammaproteobacteria	G	Fructose-bisphosphate aldolase, class II, Calvin cycle subtype	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	Dabb,F_bP_aldolase
k59_1524561_1	1541065.JRFE01000029_gene3541	1.39e-90	286.0	COG0659@1|root,COG0659@2|Bacteria,1G1F1@1117|Cyanobacteria,3VJ8P@52604|Pleurocapsales	1117|Cyanobacteria	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1573149_1	391615.ABSJ01000054_gene1429	2.81e-97	293.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1J4PA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006520,GO:0006553,GO:0006563,GO:0006564,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0034641,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046394,GO:0046451,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901615,GO:1901617	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iEcE24377_1341.EcE24377A_1004,iPC815.YPO1389,iYL1228.KPN_00935	Aminotran_5
k59_1692202_1	367299.JOEE01000001_gene2118	1e-141	425.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4FE7V@85021|Intrasporangiaceae	201174|Actinobacteria	C	COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1290534_1	644282.Deba_1743	3.18e-54	193.0	COG0493@1|root,COG2878@1|root,COG0493@2|Bacteria,COG2878@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2WIVF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Fe-S cluster domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fer4,Fer4_20,Pyr_redox_2,Pyr_redox_3
k59_1221900_1	1121468.AUBR01000052_gene1614	4.82e-21	98.2	COG4584@1|root,COG4584@2|Bacteria,1TR5X@1239|Firmicutes,25D02@186801|Clostridia,42FJ4@68295|Thermoanaerobacterales	186801|Clostridia	L	COGs COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,Mu-transpos_C,rve
k59_1221900_2	1141106.CAIB01000182_gene1788	2.57e-11	65.9	COG1484@1|root,COG1484@2|Bacteria,1UYIT@1239|Firmicutes,4HC2H@91061|Bacilli,4GZUE@90964|Staphylococcaceae	91061|Bacilli	L	Bacterial dnaA  protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_574533_1	933262.AXAM01000073_gene3358	4.22e-71	222.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2WJMN@28221|Deltaproteobacteria,2MIBA@213118|Desulfobacterales	28221|Deltaproteobacteria	J	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24,SEC-C
k59_515634_1	756272.Plabr_4205	5.36e-97	292.0	COG1089@1|root,COG1089@2|Bacteria,2IWZ4@203682|Planctomycetes	203682|Planctomycetes	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
k59_1524614_1	266265.Bxe_C0471	1.9e-17	77.8	COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,2VSH9@28216|Betaproteobacteria,1K7MV@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Pfam IS66 Orf2	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k59_869713_1	2340.JV46_14790	2.13e-111	328.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1J5D9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iAF1260.b1091,iAPECO1_1312.APECO1_172,iBWG_1329.BWG_0939,iE2348C_1286.E2348C_1183,iEC55989_1330.EC55989_1203,iECABU_c1320.ECABU_c13040,iECDH10B_1368.ECDH10B_1163,iECDH1ME8569_1439.ECDH1ME8569_1026,iECED1_1282.ECED1_1234,iECH74115_1262.ECH74115_1470,iECIAI39_1322.ECIAI39_2070,iECO103_1326.ECO103_1136,iECO111_1330.ECO111_1368,iECO26_1355.ECO26_1424,iECOK1_1307.ECOK1_1198,iECP_1309.ECP_1083,iECS88_1305.ECS88_1105,iECSP_1301.ECSP_1392,iECW_1372.ECW_m1199,iECs_1301.ECs1469,iEKO11_1354.EKO11_2743,iETEC_1333.ETEC_1156,iEcDH1_1363.EcDH1_2556,iEcE24377_1341.EcE24377A_1212,iEcSMS35_1347.EcSMS35_2036,iG2583_1286.G2583_1351,iJO1366.b1091,iJR904.b1091,iLF82_1304.LF82_0609,iNRG857_1313.NRG857_05260,iSSON_1240.SSON_1111,iSbBS512_1146.SbBS512_E2233,iUMN146_1321.UM146_11870,iUMNK88_1353.UMNK88_1361,iUTI89_1310.UTI89_C1216,iWFL_1372.ECW_m1199,iY75_1357.Y75_RS05700,iZ_1308.Z1730,ic_1306.c1360	ACP_syn_III,ACP_syn_III_C
k59_515637_1	911045.PSE_p0313	5.57e-52	176.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2TQN1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_515637_2	1288298.rosmuc_01951	1.82e-46	162.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2TSZN@28211|Alphaproteobacteria,46NCK@74030|Roseovarius	28211|Alphaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
k59_752441_1	998088.B565_0064	3.31e-65	208.0	COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,1RP2S@1236|Gammaproteobacteria,1Y3ZN@135624|Aeromonadales	135624|Aeromonadales	GM	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose	hldD	-	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase
k59_1573187_1	1177928.TH2_14539	4.86e-23	102.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2TRBX@28211|Alphaproteobacteria,2JPQR@204441|Rhodospirillales	204441|Rhodospirillales	M	COG4591 ABC-type transport system, involved in lipoprotein release, permease component	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_1398632_1	443144.GM21_3395	4.27e-08	54.3	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2WIKU@28221|Deltaproteobacteria,43TN4@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1,7-bisphosphate	hldE	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_0922	CTP_transf_like,PfkB
k59_1398632_2	1232437.KL662023_gene899	1.05e-29	115.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,42SV9@68525|delta/epsilon subdivisions,2WPXX@28221|Deltaproteobacteria,2MJUD@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Phosphoribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
k59_1459007_1	1307436.PBF_00510	6.22e-15	77.4	COG1178@1|root,COG1178@2|Bacteria,1TPMX@1239|Firmicutes,4HBPX@91061|Bacilli,1ZQES@1386|Bacillus	91061|Bacilli	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_1459007_2	1122134.KB893650_gene513	9.69e-23	96.7	COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,1RQ6Z@1236|Gammaproteobacteria,1XHSC@135619|Oceanospirillales	135619|Oceanospirillales	P	Iron deficiency-induced protein A	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
k59_1158456_1	342610.Patl_3904	1.77e-17	89.4	COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria	1224|Proteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,STN,TonB_dep_Rec
k59_1044249_1	926569.ANT_11400	5.05e-41	154.0	COG0768@1|root,COG0772@1|root,COG0768@2|Bacteria,COG0772@2|Bacteria,2G6NR@200795|Chloroflexi	200795|Chloroflexi	D	Belongs to the SEDS family	-	-	-	-	-	-	-	-	-	-	-	-	FTSW_RODA_SPOVE
k59_754149_1	1043205.AFYF01000061_gene2825	6.32e-19	86.7	COG2366@1|root,COG2366@2|Bacteria,2GISQ@201174|Actinobacteria,4FER7@85021|Intrasporangiaceae	201174|Actinobacteria	S	penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_754149_2	367299.JOEE01000006_gene894	3.02e-41	141.0	COG0212@1|root,COG0212@2|Bacteria,2IKWR@201174|Actinobacteria,4FH14@85021|Intrasporangiaceae	201174|Actinobacteria	H	5-formyltetrahydrofolate cyclo-ligase	ygfA	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
k59_1760096_1	1123228.AUIH01000080_gene520	1.68e-122	374.0	COG0642@1|root,COG2205@2|Bacteria,1MXH7@1224|Proteobacteria,1RQZW@1236|Gammaproteobacteria,1XJBY@135619|Oceanospirillales	135619|Oceanospirillales	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_644559_1	1111121.HMPREF1247_0722	2.35e-05	46.2	COG0294@1|root,COG0801@1|root,COG0294@2|Bacteria,COG0801@2|Bacteria,2GJDQ@201174|Actinobacteria,4CUFA@84998|Coriobacteriia	84998|Coriobacteriia	H	dihydropteroate synthase	folP	-	-	-	-	-	-	-	-	-	-	-	HPPK,Pterin_bind
k59_644559_2	1385520.N802_10565	2.06e-98	290.0	COG0302@1|root,COG0302@2|Bacteria,2GP2P@201174|Actinobacteria,4FE4X@85021|Intrasporangiaceae	201174|Actinobacteria	H	GTP cyclohydrolase	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3609c	GTP_cyclohydroI
k59_1408572_1	1121405.dsmv_0036	2.05e-146	440.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2MI4Z@213118|Desulfobacterales	28221|Deltaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_1642481_1	572479.Hprae_1601	0.000974	42.0	COG1281@1|root,COG1281@2|Bacteria,1TRCH@1239|Firmicutes,24940@186801|Clostridia,3WB65@53433|Halanaerobiales	186801|Clostridia	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
k59_1642481_2	1123355.JHYO01000011_gene1425	2.7e-48	164.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2TQZA@28211|Alphaproteobacteria,36XD6@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Methylenetetrahydrofolate reductase	metF	GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
k59_525463_1	768671.ThimaDRAFT_3603	6.9e-58	184.0	COG1230@1|root,COG1230@2|Bacteria,1MUSS@1224|Proteobacteria,1RQ3M@1236|Gammaproteobacteria,1X266@135613|Chromatiales	135613|Chromatiales	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
k59_1170563_1	1191523.MROS_0476	4.61e-118	354.0	COG0388@1|root,COG0454@1|root,COG0388@2|Bacteria,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yhcX	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,CN_hydrolase
k59_1816382_1	429009.Adeg_1070	1.52e-37	140.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,42EZK@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1
k59_811714_1	96561.Dole_3185	1.5e-112	342.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MHKH@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
k59_1170612_2	439235.Dalk_2419	7.25e-57	192.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42QJF@68525|delta/epsilon subdivisions,2WJ9D@28221|Deltaproteobacteria,2MIGZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
k59_584930_1	1366050.N234_32645	9.89e-105	320.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2VH45@28216|Betaproteobacteria,1K2AT@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Sulfate permease family	sulP	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_525520_2	292415.Tbd_2479	6.3e-71	220.0	COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,2VPFB@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Nitrate reductase gamma subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_gam
k59_644638_1	292415.Tbd_1904	2.78e-46	152.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ3Z@28216|Betaproteobacteria,1KSZ7@119069|Hydrogenophilales	119069|Hydrogenophilales	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
k59_644638_2	1123392.AQWL01000001_gene1540	7.96e-53	172.0	COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,2VQRP@28216|Betaproteobacteria,1KSU6@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Calcineurin-like phosphoesterase	-	-	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Metallophos
k59_1170618_1	667632.KB890184_gene422	2.7e-51	181.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,2VH1G@28216|Betaproteobacteria,1K024@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_1408621_1	269482.Bcep1808_5038	1.76e-26	115.0	COG2199@1|root,COG5000@1|root,COG2199@2|Bacteria,COG5000@2|Bacteria,1RGCV@1224|Proteobacteria,2VKYZ@28216|Betaproteobacteria,1K0Y2@119060|Burkholderiaceae	28216|Betaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HAMP,dCache_1
k59_1170620_1	1040986.ATYO01000005_gene6187	7.42e-09	58.9	COG3439@1|root,COG3439@2|Bacteria,1MZ38@1224|Proteobacteria,2UBVK@28211|Alphaproteobacteria,43MAN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Domain of unknown function DUF302	ccrB	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_584949_1	395493.BegalDRAFT_2369	2.69e-88	264.0	COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,1RQ9A@1236|Gammaproteobacteria,462WU@72273|Thiotrichales	72273|Thiotrichales	C	PFAM NapC NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
k59_525542_1	572477.Alvin_1555	3.08e-47	165.0	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,1RPAE@1236|Gammaproteobacteria,1WYC8@135613|Chromatiales	135613|Chromatiales	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_811739_1	697282.Mettu_0148	4.94e-40	139.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,1XE05@135618|Methylococcales	135618|Methylococcales	D	cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_811739_2	948565.AFFP02000013_gene1941	3.98e-19	85.9	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,1Y7KA@135625|Pasteurellales	135625|Pasteurellales	D	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
k59_1816434_1	713586.KB900536_gene614	3.24e-100	306.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,1WVV4@135613|Chromatiales	135613|Chromatiales	L	AAA ATPase, central domain protein	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_525559_1	589865.DaAHT2_2479	6.46e-156	447.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2MI5G@213118|Desulfobacterales	28221|Deltaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_1170669_1	710696.Intca_0352	6.35e-49	158.0	COG3654@1|root,COG3654@2|Bacteria,2IR34@201174|Actinobacteria,4FHP3@85021|Intrasporangiaceae	201174|Actinobacteria	S	Fic/DOC family	doc	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
k59_1170669_2	1386089.N865_20845	2.31e-26	98.6	2EM5W@1|root,33EV5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
k59_811766_1	999541.bgla_1g34160	7.34e-23	95.9	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2VH15@28216|Betaproteobacteria,1K48F@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_811766_2	557598.LHK_03036	2.52e-28	110.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2VJN0@28216|Betaproteobacteria,2KPTQ@206351|Neisseriales	206351|Neisseriales	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
k59_584979_1	96561.Dole_0142	3.22e-48	167.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2WIZZ@28221|Deltaproteobacteria,2MI8E@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Protein of unknown function (DUF933)	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_1170720_1	1267005.KB911258_gene446	1.02e-85	263.0	COG3768@1|root,COG3768@2|Bacteria,1MU8S@1224|Proteobacteria,2TU53@28211|Alphaproteobacteria,3N6UG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF697)	MA20_04555	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K08990	-	-	-	-	ko00000	-	-	-	DUF697
k59_525601_1	1095767.CAHD01000221_gene984	2.6e-69	231.0	COG1199@1|root,COG1199@2|Bacteria,2GKT8@201174|Actinobacteria,4F0ZQ@85016|Cellulomonadaceae	201174|Actinobacteria	KL	HELICc2	dinG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
k59_585002_1	1469245.JFBG01000019_gene1147	1.97e-99	301.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,1WWYU@135613|Chromatiales	135613|Chromatiales	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
k59_525621_1	471853.Bcav_2056	3.11e-118	355.0	COG3502@1|root,COG3502@2|Bacteria,2H2JJ@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3866)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3866
k59_525621_2	590998.Celf_1958	4.69e-25	97.1	2E71H@1|root,331K6@2|Bacteria,2HZEJ@201174|Actinobacteria,4F1GA@85016|Cellulomonadaceae	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_6
k59_644752_1	713586.KB900536_gene1585	3.37e-11	72.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1WWY6@135613|Chromatiales	135613|Chromatiales	U	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
k59_525656_1	450380.JPSY01000001_gene759	1.41e-06	51.6	2EH4F@1|root,33AWE@2|Bacteria,2I6EJ@201174|Actinobacteria,4FTHX@85023|Microbacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1170809_1	1033802.SSPSH_000418	9.01e-33	125.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	glnG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1170809_2	1197719.A464_4054	2.93e-23	98.2	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,3ZJQC@590|Salmonella	1236|Gammaproteobacteria	F	PAS fold	glnL	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
k59_1408733_1	1380391.JIAS01000011_gene5045	4.69e-08	54.3	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2U7D8@28211|Alphaproteobacteria,2JSA6@204441|Rhodospirillales	204441|Rhodospirillales	I	COG2867 Oligoketide cyclase lipid transport protein	-	-	-	ko:K18588	-	-	-	-	ko00000	-	-	-	Polyketide_cyc
k59_1408741_1	1435356.Y013_06420	7.13e-25	108.0	COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4FU51@85025|Nocardiaceae	201174|Actinobacteria	S	Transporter associated domain	corC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_811865_1	187272.Mlg_0026	2.68e-105	316.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1WWPY@135613|Chromatiales	135613|Chromatiales	I	TIGRFAM acetyl-CoA carboxylase, biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_644831_1	471853.Bcav_2063	3.98e-69	234.0	COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria	201174|Actinobacteria	L	DEAD DEAH box helicase	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
k59_1760341_1	471853.Bcav_0002	1.09e-65	211.0	COG0592@1|root,COG0592@2|Bacteria,2GJK3@201174|Actinobacteria	201174|Actinobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_811869_2	1027273.GZ77_12535	1.28e-17	84.0	COG3087@1|root,COG3087@2|Bacteria,1MYFG@1224|Proteobacteria,1SD3J@1236|Gammaproteobacteria,1XM0V@135619|Oceanospirillales	135619|Oceanospirillales	D	cell division protein	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
k59_811869_3	443143.GM18_1338	9.32e-59	197.0	COG2843@1|root,COG2843@2|Bacteria	2|Bacteria	M	Bacterial capsule synthesis protein PGA_cap	capA	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
k59_1642739_1	1001585.MDS_4955	1.73e-73	238.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1YCU3@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_644857_1	631362.Thi970DRAFT_03958	1.3e-113	342.0	COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,1RR67@1236|Gammaproteobacteria,1WX31@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_1642740_1	159087.Daro_0833	1.17e-67	226.0	COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,2VIFM@28216|Betaproteobacteria,2KV4T@206389|Rhodocyclales	206389|Rhodocyclales	T	Type IV pili methyl-accepting chemotaxis transducer N-term	-	-	2.7.13.3	ko:K07673	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3,PilJ
k59_235232_2	314292.VAS14_02763	1.74e-47	160.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,1XTQ4@135623|Vibrionales	135623|Vibrionales	J	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
k59_469953_1	1403819.BATR01000062_gene1896	6.05e-23	95.1	2C85M@1|root,334CZ@2|Bacteria,46WIF@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Stress responsive A/B Barrel Domain	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
k59_1350561_1	247633.GP2143_14061	5.64e-48	165.0	COG0515@1|root,COG0515@2|Bacteria,1MXX9@1224|Proteobacteria,1RQFJ@1236|Gammaproteobacteria,1JAH5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Lipopolysaccharide kinase (Kdo/WaaP) family	rfaP	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237	-	ko:K02848	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF1260.b3630,iBWG_1329.BWG_3321,iEC042_1314.EC042_3937,iECDH10B_1368.ECDH10B_3812,iECDH1ME8569_1439.ECDH1ME8569_3515,iEcDH1_1363.EcDH1_0075,iJO1366.b3630,iY75_1357.Y75_RS18985	Kdo
k59_939922_1	1288826.MSNKSG1_17001	9.24e-40	147.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,463ZU@72275|Alteromonadaceae	1236|Gammaproteobacteria	FP	Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the stringent response , an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities	gppA	GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006082,GO:0006139,GO:0006725,GO:0006793,GO:0006797,GO:0006798,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008894,GO:0009056,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034641,GO:0042594,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:1901360,GO:1901575	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c42590,iECED1_1282.ECED1_4463,iECIAI39_1322.ECIAI39_2643	HD,Ppx-GppA
k59_1585340_1	1121405.dsmv_1003	2.28e-98	309.0	COG0204@1|root,COG1647@1|root,COG0204@2|Bacteria,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,42NBK@68525|delta/epsilon subdivisions,2WIUP@28221|Deltaproteobacteria,2MHMP@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Acyltransferase,Hydrolase_4
k59_1467999_1	593907.Celgi_1892	4.39e-96	300.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4F0WR@85016|Cellulomonadaceae	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1292148_1	338966.Ppro_0557	2.03e-26	98.2	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WR92@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM Cold-shock protein, DNA-binding	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_1292148_2	1121403.AUCV01000006_gene420	1.59e-11	62.8	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,42QPB@68525|delta/epsilon subdivisions,2WMP0@28221|Deltaproteobacteria,2MJM0@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07664	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_881277_2	1123487.KB892864_gene2213	1.92e-56	186.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,2KVK1@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_587403_1	1304865.JAGF01000001_gene3604	8.64e-65	221.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4F0IU@85016|Cellulomonadaceae	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_587403_2	326424.FRAAL2179	4.65e-13	70.1	COG0389@1|root,COG0389@2|Bacteria,2GMZ3@201174|Actinobacteria,4ES7K@85013|Frankiales	201174|Actinobacteria	L	impB/mucB/samB family	dinB_2	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
k59_881285_1	640081.Dsui_0101	1.81e-33	128.0	COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2VK3W@28216|Betaproteobacteria,2KUJD@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA polymerase III, epsilon subunit	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T
k59_881285_2	639283.Snov_3492	1.61e-40	142.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,2TVCS@28211|Alphaproteobacteria,3F04M@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Carbon-nitrogen hydrolase	aguB	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
k59_587404_1	765912.Thimo_0895	5.85e-87	286.0	COG4678@1|root,COG4678@2|Bacteria,1MXCR@1224|Proteobacteria,1RPZR@1236|Gammaproteobacteria,1WW1Z@135613|Chromatiales	135613|Chromatiales	G	PFAM TraG-like protein, N-terminal region	-	-	-	ko:K12056	-	-	-	-	ko00000,ko02044	3.A.7.11.1	-	-	TraG_N
k59_1761484_1	1306174.JODP01000001_gene5104	0.000448	42.4	COG0507@1|root,COG0507@2|Bacteria,2GIX1@201174|Actinobacteria	201174|Actinobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	recD	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,UvrD_C_2
k59_1761484_2	1123251.ATWM01000007_gene2389	1.06e-67	226.0	COG0530@1|root,COG0530@2|Bacteria,2GJR3@201174|Actinobacteria,4FIXG@85021|Intrasporangiaceae	201174|Actinobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_293867_1	1454004.AW11_03269	3.64e-111	343.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2VGZZ@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_939980_1	631362.Thi970DRAFT_03274	1.48e-45	157.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1X2CM@135613|Chromatiales	135613|Chromatiales	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1761487_1	713586.KB900536_gene1664	8.57e-41	142.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1WW6P@135613|Chromatiales	135613|Chromatiales	E	Belongs to the TrpC family	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PRAI
k59_1761487_2	309800.C498_07580	3.69e-08	55.1	COG0547@1|root,arCOG02012@2157|Archaea,2XT3C@28890|Euryarchaeota,23SMQ@183963|Halobacteria	183963|Halobacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
k59_235275_1	393595.ABO_0430	1.02e-51	169.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,1XJHS@135619|Oceanospirillales	135619|Oceanospirillales	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_1115787_1	446466.Cfla_2221	2.49e-149	434.0	COG2308@1|root,COG2308@2|Bacteria,2GN0J@201174|Actinobacteria	201174|Actinobacteria	E	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_1,CP_ATPgrasp_2
k59_881304_1	2340.JV46_23210	5.35e-75	229.0	COG0622@1|root,COG0622@2|Bacteria,1RCUQ@1224|Proteobacteria,1S2YE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
k59_881304_2	713586.KB900536_gene159	5.56e-45	154.0	COG0457@1|root,COG0457@2|Bacteria,1R85G@1224|Proteobacteria,1S0MD@1236|Gammaproteobacteria,1WXM8@135613|Chromatiales	135613|Chromatiales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_469986_1	1123508.JH636441_gene3265	3.39e-24	105.0	COG1752@1|root,COG1752@2|Bacteria,2J2A9@203682|Planctomycetes	203682|Planctomycetes	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_1585367_1	933262.AXAM01000020_gene26	3.31e-71	235.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2WJTT@28221|Deltaproteobacteria,2MITA@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
k59_1057152_1	1122211.JMLW01000001_gene2369	4.77e-41	139.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,1XJPI@135619|Oceanospirillales	135619|Oceanospirillales	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
k59_1057152_2	765912.Thimo_1325	3.85e-56	182.0	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria,1WXHT@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
k59_881333_1	1120999.JONM01000003_gene2700	0.000482	42.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2VI0R@28216|Betaproteobacteria,2KPYY@206351|Neisseriales	206351|Neisseriales	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_881333_2	292.DM42_4096	6e-29	110.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2VPZV@28216|Betaproteobacteria,1K0FG@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
k59_235297_1	716544.wcw_1726	1.8e-45	165.0	COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria	2|Bacteria	P	domain, Protein	sac1	-	-	ko:K03319	-	-	-	-	ko00000	2.A.47	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_117827_1	211165.AJLN01000100_gene4065	8.76e-06	54.3	COG4773@1|root,COG4773@2|Bacteria,1G13I@1117|Cyanobacteria,1JKNC@1189|Stigonemataceae	1117|Cyanobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	AMIN,Plug,TonB_dep_Rec
k59_573_1	1713.JOFV01000005_gene2196	1.52e-06	50.1	2CAW2@1|root,306MY@2|Bacteria,2I81Z@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_573_2	935839.JAGJ01000006_gene3456	3.48e-238	672.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,4F446@85017|Promicromonosporaceae	201174|Actinobacteria	E	Aminopeptidase P, N-terminal domain	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_411305_1	477184.KYC_13392	2.87e-62	202.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,2VHMU@28216|Betaproteobacteria,3T3QN@506|Alcaligenaceae	28216|Betaproteobacteria	O	DnaJ C terminal domain	cbpA	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
k59_1179645_3	944547.ABLL_0222	4.73e-22	91.3	COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,42SI3@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	conserved protein UCP020606	yjdF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
k59_8170_1	1454004.AW11_03269	1.89e-276	773.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2VGZZ@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_1238878_1	1463854.JOHT01000002_gene2296	9.88e-165	478.0	COG0168@1|root,COG0168@2|Bacteria,2GKKS@201174|Actinobacteria	201174|Actinobacteria	P	Potassium uptake protein	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_1414731_1	1121441.AUCX01000010_gene126	7.2e-14	75.1	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,42P4T@68525|delta/epsilon subdivisions,2WKBS@28221|Deltaproteobacteria,2M8DW@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
k59_651478_1	1032480.MLP_33310	4.4e-98	296.0	COG2304@1|root,COG2304@2|Bacteria,2GNKP@201174|Actinobacteria,4DPNR@85009|Propionibacteriales	201174|Actinobacteria	S	von Willebrand factor type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
k59_1355744_2	765914.ThisiDRAFT_2611	2.47e-119	362.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1WW0N@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_8181_1	471853.Bcav_3969	2.27e-141	412.0	COG0079@1|root,COG0079@2|Bacteria,2GJXS@201174|Actinobacteria	201174|Actinobacteria	E	May catalyze the transamination reaction in phenylalanine biosynthesis	pat	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1300111_1	759913.SDSE_0549	1.47e-12	72.8	COG3039@1|root,COG3039@2|Bacteria,1VTM5@1239|Firmicutes,4HT6I@91061|Bacilli,1MA08@119603|Streptococcus dysgalactiae group	91061|Bacilli	L	Transposase and inactivated derivatives, IS5 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_3
k59_888992_1	1121405.dsmv_1655	1.14e-52	186.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42Z0I@68525|delta/epsilon subdivisions,2WUFE@28221|Deltaproteobacteria,2MN2T@213118|Desulfobacterales	28221|Deltaproteobacteria	P	heavy metal translocating P-type ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_651487_1	548476.cauri_2527	4.77e-28	107.0	COG2353@1|root,COG2353@2|Bacteria,2GJUB@201174|Actinobacteria,22N35@1653|Corynebacteriaceae	201174|Actinobacteria	S	Belongs to the UPF0312 family	yceI	-	-	-	-	-	-	-	-	-	-	-	YceI
k59_651487_2	2002.JOEQ01000007_gene1900	1.28e-18	82.8	COG1611@1|root,COG1611@2|Bacteria,2GMM1@201174|Actinobacteria,4EIPT@85012|Streptosporangiales	201174|Actinobacteria	S	Possible lysine decarboxylase	-	GO:0003674,GO:0003824,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009308,GO:0009690,GO:0009691,GO:0009987,GO:0010817,GO:0016787,GO:0016798,GO:0016799,GO:0034754,GO:0042445,GO:0042446,GO:0044237,GO:0044249,GO:0046483,GO:0065007,GO:0065008,GO:0071704,GO:1901564	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_299339_1	196162.Noca_1623	1.87e-81	258.0	COG0843@1|root,COG0843@2|Bacteria	2|Bacteria	C	heme-copper terminal oxidase activity	cbaA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_8192_1	1047013.AQSP01000106_gene1765	4.92e-64	208.0	COG1509@1|root,COG1509@2|Bacteria,2NNY6@2323|unclassified Bacteria	2|Bacteria	E	lysine 2,3-aminomutase activity	kamA	-	5.4.3.2,5.4.3.9	ko:K01843,ko:K19810,ko:K19814	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000,ko03012	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
k59_67195_1	880072.Desac_1111	1.07e-143	425.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2MR7D@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_361639_1	1123229.AUBC01000029_gene3518	2.2e-87	272.0	COG0477@1|root,COG2814@2|Bacteria,1MW95@1224|Proteobacteria,2TS8H@28211|Alphaproteobacteria,3JT9X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	PUCC protein	lhaA	-	-	ko:K08226	-	-	-	-	ko00000,ko02000	2.A.1.41	-	-	PUCC
k59_9551_1	545264.KB898755_gene2830	1.42e-57	192.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WW29@135613|Chromatiales	135613|Chromatiales	S	PFAM Uncharacterised protein family UPF0027	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_889968_1	326297.Sama_0743	2.87e-17	78.2	COG3791@1|root,COG3791@2|Bacteria	2|Bacteria	S	Glutathione-dependent formaldehyde-activating	MA20_06205	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_889968_2	1530186.JQEY01000010_gene2788	3.44e-16	79.7	28NSG@1|root,2ZBRE@2|Bacteria,1RFZV@1224|Proteobacteria,2UR8M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
k59_1301075_1	1226994.AMZB01000109_gene1743	3.96e-69	221.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1YDYY@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_1590824_1	1282876.BAOK01000001_gene2719	8.12e-81	253.0	COG3386@1|root,COG3386@2|Bacteria,1MX7V@1224|Proteobacteria,2U1AZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057,ko:K10440	ko02010,map02010	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2,SGL,Str_synth
k59_1590824_3	1469607.KK073768_gene3736	7e-13	70.5	COG1670@1|root,COG1670@2|Bacteria,1GJFF@1117|Cyanobacteria,1HNA4@1161|Nostocales	1117|Cyanobacteria	J	COGs COG1670 Acetyltransferase including N-acetylase of ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_1301079_1	1395571.TMS3_0110530	2.56e-68	219.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009014,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0032153,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0046872,GO:0046914,GO:0050897,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_2485	M20_dimer,Peptidase_M20
k59_1180445_1	1121448.DGI_2643	1.16e-31	126.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,43EAS@68525|delta/epsilon subdivisions,2X7TI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_475986_1	1027273.GZ77_22380	3.02e-43	147.0	COG1662@1|root,COG1662@2|Bacteria,1RIVU@1224|Proteobacteria,1SA15@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	ko:K07480	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1
k59_475987_1	717231.Flexsi_1552	1.09e-86	271.0	COG1866@1|root,COG1866@2|Bacteria,2GEIP@200930|Deferribacteres	200930|Deferribacteres	H	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
k59_1532392_1	1517416.IDAT_04015	6.96e-67	223.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,2QF83@267893|Idiomarinaceae	1236|Gammaproteobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_889979_1	224325.AF_2290	8.05e-22	95.5	COG0123@1|root,arCOG00327@2157|Archaea,2XV92@28890|Euryarchaeota,245W6@183980|Archaeoglobi	183980|Archaeoglobi	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_1301085_1	391616.OA238_c35140	8.77e-86	265.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2TUNK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_889980_1	522306.CAP2UW1_3782	3.85e-25	98.6	COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,2VU0P@28216|Betaproteobacteria,1KQ34@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	Preprotein translocase subunit SecG	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
k59_889982_1	1128421.JAGA01000002_gene1675	6.37e-10	57.0	COG0251@1|root,COG0251@2|Bacteria,2NR4K@2323|unclassified Bacteria	2|Bacteria	J	Endoribonuclease L-PSP	rutC	-	4.2.99.21	ko:K04782	ko01053,ko01110,ko01130,map01053,map01110,map01130	-	R06602	RC01549,RC02148	ko00000,ko00001,ko01000	-	-	-	Ribonuc_L-PSP
k59_889982_2	388739.RSK20926_19407	3.8e-16	80.1	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2TSD9@28211|Alphaproteobacteria,2P1AW@2433|Roseobacter	28211|Alphaproteobacteria	K	COG0583 Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_243409_1	883.DvMF_1245	0.000178	47.4	COG0243@1|root,COG0518@1|root,COG0243@2|Bacteria,COG0518@2|Bacteria,1NR6J@1224|Proteobacteria,42MYN@68525|delta/epsilon subdivisions,2WIND@28221|Deltaproteobacteria,2M7TC@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	GATase,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1003483_1	765910.MARPU_02035	8.13e-129	387.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria,1WXUR@135613|Chromatiales	135613|Chromatiales	P	PFAM Na Picotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
k59_1415518_1	394221.Mmar10_1233	2.63e-63	213.0	COG0500@1|root,COG3000@1|root,COG2226@2|Bacteria,COG3000@2|Bacteria,1PPKI@1224|Proteobacteria,2TRIB@28211|Alphaproteobacteria,43XEV@69657|Hyphomonadaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_1415518_2	247639.MGP2080_08771	3.19e-49	169.0	COG3391@1|root,COG3391@2|Bacteria,1MXDX@1224|Proteobacteria,1S012@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	56kDa selenium binding protein (SBP56)	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
k59_1474836_1	367299.JOEE01000002_gene2404	3.22e-106	317.0	COG1294@1|root,COG1294@2|Bacteria,2GMFV@201174|Actinobacteria,4FEJA@85021|Intrasporangiaceae	201174|Actinobacteria	C	Cytochrome C oxidase assembly protein	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
k59_1474836_2	1210046.B277_02129	2.06e-13	69.7	COG4988@1|root,COG4988@2|Bacteria,2I2DP@201174|Actinobacteria,4FFQC@85021|Intrasporangiaceae	201174|Actinobacteria	V	ABC transporter	cydD	-	-	ko:K16013,ko:K16014	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.129	-	-	ABC_membrane,ABC_tran
k59_827996_1	1304865.JAGF01000001_gene123	3.96e-151	437.0	COG1432@1|root,COG1432@2|Bacteria,2I9HK@201174|Actinobacteria	201174|Actinobacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
k59_652184_1	439235.Dalk_2506	1.28e-99	300.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,2MHVQ@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_1063607_2	1335757.SPICUR_00535	3.47e-28	105.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,1S3PX@1236|Gammaproteobacteria,1WY3G@135613|Chromatiales	135613|Chromatiales	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
k59_827997_1	1049564.TevJSym_aq00120	1.89e-52	167.0	2F88A@1|root,340MG@2|Bacteria,1NXS1@1224|Proteobacteria,1SQ1P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Phosphoribosyl-ATP pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG
k59_827997_2	1123228.AUIH01000012_gene88	0.00011	43.9	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1XH7W@135619|Oceanospirillales	135619|Oceanospirillales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_1301105_1	391625.PPSIR1_15520	2.39e-62	205.0	COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria	1224|Proteobacteria	S	protein related to deoxyribodipyrimidine photolyase	phrB	GO:0000166,GO:0000719,GO:0003674,GO:0003824,GO:0003913,GO:0003914,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0033554,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0071949,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP
k59_1003487_1	365046.Rta_33920	1.63e-96	290.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2VH6G@28216|Betaproteobacteria,4ABRZ@80864|Comamonadaceae	28216|Betaproteobacteria	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_1239930_1	1026882.MAMP_01228	1.08e-86	276.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,45ZQ4@72273|Thiotrichales	72273|Thiotrichales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1415527_1	290397.Adeh_3064	3.21e-18	86.7	28WYN@1|root,33TG0@2|Bacteria,1NTYC@1224|Proteobacteria,42YTU@68525|delta/epsilon subdivisions,2WU4Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	6 heme-binding sites	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_948911_1	648757.Rvan_1646	7.85e-65	214.0	COG3596@1|root,COG3596@2|Bacteria,1P6GT@1224|Proteobacteria,2UAIT@28211|Alphaproteobacteria,3N8AE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	50S ribosome-binding GTPase	-	-	-	ko:K06946	-	-	-	-	ko00000	-	-	-	MMR_HSR1
k59_534803_1	1049564.TevJSym_ah00220	2.6e-32	115.0	COG1993@1|root,COG1993@2|Bacteria,1N8TP@1224|Proteobacteria,1SDYH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
k59_534803_2	243233.MCA1973	4.89e-15	73.9	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1S8RQ@1236|Gammaproteobacteria,1XFC3@135618|Methylococcales	135618|Methylococcales	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
k59_828005_1	717785.HYPMC_1740	3.05e-107	333.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3N9EM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1239934_2	388051.AUFE01000087_gene5558	1.2e-54	176.0	COG2030@1|root,COG2030@2|Bacteria,1RHPH@1224|Proteobacteria,2W1GH@28216|Betaproteobacteria,1K71F@119060|Burkholderiaceae	28216|Betaproteobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
k59_1829262_1	471853.Bcav_1363	2.79e-27	110.0	COG0482@1|root,COG0482@2|Bacteria,2GIUQ@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_1708597_2	754477.Q7C_1861	6.97e-12	65.5	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,45ZX9@72273|Thiotrichales	72273|Thiotrichales	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_1003493_1	590998.Celf_0939	4.71e-91	293.0	COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,4F0S5@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1063623_1	471853.Bcav_2418	1.69e-149	430.0	COG0275@1|root,COG0275@2|Bacteria,2GJGK@201174|Actinobacteria	201174|Actinobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_828013_1	876044.IMCC3088_1984	3.5e-06	49.3	COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,1S2TG@1236|Gammaproteobacteria,1J80M@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Beta-lactamase superfamily domain	yycJ	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_828013_2	396588.Tgr7_1232	8.96e-83	248.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,1RPW7@1236|Gammaproteobacteria,1WX8C@135613|Chromatiales	135613|Chromatiales	J	Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
k59_1239943_1	572477.Alvin_1799	1.27e-73	233.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,1RPCE@1236|Gammaproteobacteria,1WXRF@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase family 2	-	-	2.4.2.53	ko:K10012,ko:K20534	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8,4.D.2.1.9	GT2	-	Glycos_transf_2
k59_417095_1	1081644.IMCC13023_02840	3.74e-65	206.0	COG1174@1|root,COG1174@2|Bacteria,2GMQT@201174|Actinobacteria,4FNRX@85023|Microbacteriaceae	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	opuBB_3	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
k59_417095_2	1394178.AWOO02000085_gene985	8.7e-18	81.6	COG1125@1|root,COG1125@2|Bacteria,2GJHI@201174|Actinobacteria,4EH2R@85012|Streptosporangiales	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran,BPD_transp_1,CBS
k59_1474877_1	1232437.KL661986_gene3666	1.6e-43	148.0	COG2041@1|root,COG2041@2|Bacteria	2|Bacteria	V	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
k59_1003500_1	1267005.KB911256_gene1850	3.32e-81	256.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2TS87@28211|Alphaproteobacteria,3N62M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
k59_948923_1	396588.Tgr7_2304	2.29e-232	649.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1WWJA@135613|Chromatiales	135613|Chromatiales	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_1063641_1	754477.Q7C_6	3.36e-47	157.0	COG1704@1|root,COG1704@2|Bacteria,1R9YG@1224|Proteobacteria,1T06D@1236|Gammaproteobacteria,460MN@72273|Thiotrichales	72273|Thiotrichales	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_1063641_2	1123261.AXDW01000010_gene363	2.53e-06	49.7	COG1704@1|root,COG1704@2|Bacteria,1RDUH@1224|Proteobacteria,1S2KR@1236|Gammaproteobacteria,1XDGA@135614|Xanthomonadales	135614|Xanthomonadales	S	E3 Ubiquitin ligase	-	-	-	-	-	-	-	-	-	-	-	-	GIDE
k59_890028_1	582899.Hden_3140	7.57e-43	151.0	COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2U6K4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG0631 Serine threonine protein phosphatase	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
k59_1532427_2	396588.Tgr7_2050	6.19e-14	73.9	COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria,1WWUQ@135613|Chromatiales	135613|Chromatiales	NU	TIGRFAM type IV pilus biogenesis stability protein PilW	-	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	LysM,TPR_10,TPR_14,TPR_16,TPR_17,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
k59_1708607_1	909663.KI867150_gene488	7.88e-15	76.6	COG2197@1|root,COG2197@2|Bacteria,1R3YQ@1224|Proteobacteria,42N0Q@68525|delta/epsilon subdivisions,2WM6W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,PAS_4,PAS_9
k59_476030_1	1449350.OCH239_14745	4.03e-112	327.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_1301139_1	768671.ThimaDRAFT_4428	1.46e-111	328.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,1WZPM@135613|Chromatiales	135613|Chromatiales	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_9657_1	349521.HCH_05975	3.16e-33	117.0	COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,1SCMH@1236|Gammaproteobacteria,1XM5V@135619|Oceanospirillales	135619|Oceanospirillales	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
k59_9657_2	909663.KI867150_gene976	0.000302	43.9	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,42P1P@68525|delta/epsilon subdivisions,2X8IJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_948930_1	216594.MMAR_3548	9.52e-09	56.2	COG1309@1|root,COG1309@2|Bacteria,2GP92@201174|Actinobacteria,234M0@1762|Mycobacteriaceae	201174|Actinobacteria	K	tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_948930_2	1117314.PCIT_21960	2.44e-96	302.0	COG1231@1|root,COG1231@2|Bacteria,1R5ZI@1224|Proteobacteria,1S0X5@1236|Gammaproteobacteria,2Q40A@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	E	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_476032_1	522306.CAP2UW1_1241	0.00066	41.6	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2VNS5@28216|Betaproteobacteria	28216|Betaproteobacteria	E	LeuA allosteric (dimerisation) domain	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_476032_2	688246.Premu_0263	4.88e-22	94.0	COG0797@1|root,COG0797@2|Bacteria,4NSF1@976|Bacteroidetes,2FTUH@200643|Bacteroidia	976|Bacteroidetes	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1
k59_1180530_2	1227453.C444_01736	6.3e-14	74.3	COG1691@1|root,arCOG02465@2157|Archaea,2XTIH@28890|Euryarchaeota,23TKP@183963|Halobacteria	183963|Halobacteria	S	COG1691 NCAIR mutase (PurE)-related proteins	purE2	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
k59_1063659_1	1198232.CYCME_0382	4.02e-12	67.0	28I6N@1|root,2Z89J@2|Bacteria,1MUVT@1224|Proteobacteria,1RQUY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1063659_2	1278309.KB907099_gene2855	1.92e-68	216.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,1RNEH@1236|Gammaproteobacteria,1XI7Y@135619|Oceanospirillales	135619|Oceanospirillales	P	ABC-type nitrate sulfonate bicarbonate transport system, ATPase component	nasD	-	-	ko:K15578	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16.1	-	-	ABC_tran
k59_710856_1	1047013.AQSP01000086_gene2012	8e-21	86.3	COG0080@1|root,COG0080@2|Bacteria,2NP7W@2323|unclassified Bacteria	2|Bacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0015968,GO:0016043,GO:0019538,GO:0019843,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0032984,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0065003,GO:0070925,GO:0071496,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_710856_2	234267.Acid_5460	1.65e-65	206.0	COG0081@1|root,COG0081@2|Bacteria,3Y2HX@57723|Acidobacteria	57723|Acidobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_1120866_1	1219077.VAZ01S_016_00370	4.24e-07	57.4	COG0510@1|root,COG0510@2|Bacteria,1MURU@1224|Proteobacteria,1RNUN@1236|Gammaproteobacteria,1XTBI@135623|Vibrionales	135623|Vibrionales	M	choline kinase involved in LPS biosynthesis	thiK	-	-	-	-	-	-	-	-	-	-	-	APH,Choline_kinase
k59_1063666_1	1279009.ADICEAN_00074	1.33e-101	313.0	COG1053@1|root,COG1053@2|Bacteria,4NFDU@976|Bacteroidetes,47JE5@768503|Cytophagia	976|Bacteroidetes	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1070565_2	765910.MARPU_06230	9.48e-70	229.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1WWD1@135613|Chromatiales	135613|Chromatiales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_367752_1	1123401.JHYQ01000003_gene2122	4.1e-73	234.0	COG0028@1|root,COG0028@2|Bacteria,1MWVW@1224|Proteobacteria,1SN0M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_18197_1	543728.Vapar_5343	2.05e-31	120.0	2DN0A@1|root,32UPR@2|Bacteria,1N1BR@1224|Proteobacteria,2VRRJ@28216|Betaproteobacteria,4AHR2@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_954984_1	519989.ECTPHS_07326	6.63e-92	290.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWI3@135613|Chromatiales	135613|Chromatiales	L	PFAM UvrD REP helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1070568_1	243233.MCA3000	1.85e-81	266.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1XDXS@135618|Methylococcales	135618|Methylococcales	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_74262_1	1121439.dsat_2305	2.91e-69	218.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WKXU@28221|Deltaproteobacteria,2M80I@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_304098_1	1122929.KB908230_gene3708	3.62e-58	189.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2TRSF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the BI1 family	ybhL	-	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
k59_1835377_1	1249627.D779_4132	7.18e-33	125.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1WWGK@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
k59_1771114_1	1168059.KB899087_gene3059	1.36e-45	161.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2TR40@28211|Alphaproteobacteria,3EYHE@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190,2.1.1.35	ko:K00557,ko:K03215	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	tRNA_U5-meth_tr
k59_74269_1	159087.Daro_0567	3.86e-22	100.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2VIAX@28216|Betaproteobacteria,2KVU3@206389|Rhodocyclales	1224|Proteobacteria	C	COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M)	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_74269_2	1454004.AW11_01552	5.6e-18	86.7	COG1009@1|root,COG1009@2|Bacteria,1R5G2@1224|Proteobacteria,2VZ5Y@28216|Betaproteobacteria,1KR7S@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M,Proton_antipo_N
k59_367767_1	1123360.thalar_01589	5.95e-34	134.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2TRKK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	mechanosensitive ion channel	kefA	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	DUF3772,MS_channel
k59_251881_1	935261.JAGL01000003_gene3079	4.6e-42	143.0	2CCJB@1|root,32U00@2|Bacteria,1N1Q4@1224|Proteobacteria,2UCHJ@28211|Alphaproteobacteria,43K0B@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_715492_1	1265310.CCBD010000014_gene3761	3.45e-73	231.0	COG2020@1|root,COG2020@2|Bacteria,2GN9N@201174|Actinobacteria,2336J@1762|Mycobacteriaceae	201174|Actinobacteria	O	NnrU protein	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU
k59_251884_1	87626.PTD2_00656	2.71e-59	193.0	COG4798@1|root,COG4798@2|Bacteria,1RHGZ@1224|Proteobacteria,1S2WK@1236|Gammaproteobacteria,2Q3KE@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Methyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,PCMT,Ubie_methyltran
k59_1835388_2	1042326.AZNV01000020_gene1061	2.4e-06	49.7	COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,2TVJN@28211|Alphaproteobacteria,4B7T8@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	membrane-associated, metal-dependent hydrolase	eptA	-	2.7.8.43	ko:K03760,ko:K19353	ko00540,ko01503,map00540,map01503	M00722	R11555,R11556,R11557	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DUF1705,Sulfatase
k59_597450_1	251221.35213098	4.42e-23	92.0	COG0724@1|root,COG0724@2|Bacteria,1G7Q7@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	rbpD	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_597450_2	1121456.ATVA01000012_gene2596	9.96e-19	79.7	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42V9Q@68525|delta/epsilon subdivisions,2WRRT@28221|Deltaproteobacteria,2MCID@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_421442_1	1190603.AJYD01000024_gene486	7.89e-36	127.0	2ANPA@1|root,31DNS@2|Bacteria,1RHTE@1224|Proteobacteria,1S2Z7@1236|Gammaproteobacteria,1XWZY@135623|Vibrionales	135623|Vibrionales	S	Protein of unknown function (DUF3833)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3833
k59_421442_2	396588.Tgr7_1387	9.04e-18	85.5	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,1X0DP@135613|Chromatiales	135613|Chromatiales	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
k59_955008_1	243233.MCA1687	5.96e-91	288.0	COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,1RXZ7@1236|Gammaproteobacteria,1XE3M@135618|Methylococcales	135618|Methylococcales	S	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
k59_597453_1	665956.HMPREF1032_00672	6.43e-165	476.0	COG4626@1|root,COG4626@2|Bacteria,1TT9I@1239|Firmicutes,24AFK@186801|Clostridia,3WNF4@541000|Ruminococcaceae	186801|Clostridia	S	Phage Terminase	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_1
k59_832674_1	767029.HMPREF9154_1504	5.85e-108	323.0	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria,4DT3W@85009|Propionibacteriales	201174|Actinobacteria	G	Alpha amylase, catalytic domain	nplT	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3459
k59_1835400_2	1121939.L861_17860	1.04e-54	179.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,1RQJT@1236|Gammaproteobacteria,1XH77@135619|Oceanospirillales	135619|Oceanospirillales	IQ	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
k59_1771133_1	991905.SL003B_3397	6.09e-127	375.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,4BP7R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_251912_1	290340.AAur_0173	3.67e-139	404.0	COG2376@1|root,COG2376@2|Bacteria,2GJV9@201174|Actinobacteria,1W94S@1268|Micrococcaceae	201174|Actinobacteria	G	Dihydroxyacetone kinase	dhaK	-	2.7.1.121,2.7.1.210,2.7.1.28,2.7.1.29,4.6.1.15	ko:K00863,ko:K05878,ko:K20902	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	M00344	R01011,R01012,R01059,R11461	RC00002,RC00015,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Dak1
k59_955019_1	314287.GB2207_10026	4.7e-50	168.0	COG0830@1|root,COG0830@2|Bacteria,1MW8Q@1224|Proteobacteria,1RP91@1236|Gammaproteobacteria,1J6BW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureF	-	-	ko:K03188	-	-	-	-	ko00000	-	-	-	UreF
k59_18265_1	1232410.KI421425_gene1546	4.98e-26	101.0	COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,42TN7@68525|delta/epsilon subdivisions,2WQK7@28221|Deltaproteobacteria,43TGA@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_18265_2	1232410.KI421425_gene1547	3.89e-35	123.0	2EQ5T@1|root,32ZV0@2|Bacteria,1NFTI@1224|Proteobacteria,433CK@68525|delta/epsilon subdivisions,2WXC2@28221|Deltaproteobacteria,43VWA@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1536558_2	631362.Thi970DRAFT_04790	2.03e-116	352.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1WWE5@135613|Chromatiales	135613|Chromatiales	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_715510_2	754476.Q7A_304	3.06e-133	382.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,1RN3M@1236|Gammaproteobacteria,45ZZE@72273|Thiotrichales	72273|Thiotrichales	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_1185335_1	471853.Bcav_0274	9.09e-117	347.0	COG2233@1|root,COG2233@2|Bacteria,2GMH6@201174|Actinobacteria	201174|Actinobacteria	F	Xanthine uracil	rutG	-	-	ko:K02824,ko:K03458	-	-	-	-	ko00000,ko02000	2.A.40,2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
k59_480286_1	765911.Thivi_3494	1.33e-114	354.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1WWJI@135613|Chromatiales	135613|Chromatiales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_1246185_1	1123256.KB907926_gene865	1.04e-49	174.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1X4XY@135614|Xanthomonadales	135614|Xanthomonadales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_1594994_2	1144275.COCOR_03167	8.41e-40	142.0	COG3900@1|root,COG3900@2|Bacteria,1RKQP@1224|Proteobacteria,42US2@68525|delta/epsilon subdivisions,2WQT6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
k59_1712695_1	1049564.TevJSym_ab01540	7.5e-39	149.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J57S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	cation transport ATPase	copA	GO:0000041,GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006950,GO:0008150,GO:0008324,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010272,GO:0010273,GO:0015075,GO:0015080,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035434,GO:0042221,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046688,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0060003,GO:0061687,GO:0070887,GO:0071241,GO:0071248,GO:0071280,GO:0071292,GO:0071944,GO:0090662,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0099131,GO:1902601,GO:1990169	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	iEC55989_1330.EC55989_0497,iECIAI1_1343.ECIAI1_0487,iECO103_1326.ECO103_0460,iECSE_1348.ECSE_0509,iECW_1372.ECW_m0557,iEKO11_1354.EKO11_3363,iWFL_1372.ECW_m0557	E1-E2_ATPase,HMA,Hydrolase
k59_896076_1	768671.ThimaDRAFT_0913	6.15e-99	303.0	2DBUZ@1|root,2ZB8W@2|Bacteria,1QWGF@1224|Proteobacteria,1SN24@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1246198_1	1458427.BAWN01000054_gene2153	3.24e-14	72.0	COG2963@1|root,COG2963@2|Bacteria,1N7SX@1224|Proteobacteria,2VVQR@28216|Betaproteobacteria,4AFKH@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM transposase IS3 IS911 family protein	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_539097_1	1120941.AUBL01000048_gene2701	2.32e-35	125.0	COG0229@1|root,COG0229@2|Bacteria,2IHV0@201174|Actinobacteria,4D5ID@85005|Actinomycetales	201174|Actinobacteria	C	Peptide-methionine (R)-S-oxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
k59_1712701_1	587753.EY04_30175	9.76e-12	67.0	COG1716@1|root,COG3456@1|root,COG1716@2|Bacteria,COG3456@2|Bacteria,1R9YP@1224|Proteobacteria,1S3BS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	conserved protein, contains FHA domain	-	-	-	ko:K11894	-	-	-	-	ko00000,ko02044	3.A.23.1	-	-	FHA
k59_1712701_2	472759.Nhal_2803	5.33e-37	128.0	COG4517@1|root,COG4517@2|Bacteria,1MZJX@1224|Proteobacteria,1S95D@1236|Gammaproteobacteria,1WZ3B@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF1820)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1820
k59_896087_2	556267.HWAG_00249	5.86e-07	54.7	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42M4C@68525|delta/epsilon subdivisions	1224|Proteobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
k59_18322_1	13690.CP98_04778	2.84e-78	241.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2K4Q4@204457|Sphingomonadales	204457|Sphingomonadales	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve_3
k59_1007751_1	580332.Slit_2318	1.89e-15	70.9	COG2501@1|root,COG2501@2|Bacteria,1N7NW@1224|Proteobacteria,2VVQY@28216|Betaproteobacteria,44W1T@713636|Nitrosomonadales	28216|Betaproteobacteria	S	S4 domain	ybcJ	-	-	ko:K14761	-	-	-	-	ko00000,ko03009	-	-	-	S4_2
k59_1655890_1	880071.Fleli_4062	4.92e-20	89.0	COG1092@1|root,COG1092@2|Bacteria,4NG9S@976|Bacteroidetes,47M5H@768503|Cytophagia	976|Bacteroidetes	J	SAM-dependent methyltransferase	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
k59_1655890_2	413404.Rmag_0719	1.64e-05	47.8	2E4SV@1|root,32ZM7@2|Bacteria,1N8VN@1224|Proteobacteria,1S6AW@1236|Gammaproteobacteria,1J73R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative transmembrane protein (PGPGW)	-	-	-	-	-	-	-	-	-	-	-	-	PGPGW
k59_833477_1	1121937.AUHJ01000007_gene1873	1.97e-40	136.0	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,466TX@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Belongs to the glutaredoxin family. Monothiol subfamily	grxD	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin,Rhodanese
k59_368881_1	595537.Varpa_1073	8.29e-93	281.0	COG0687@1|root,COG0687@2|Bacteria,1MU0I@1224|Proteobacteria,2VICQ@28216|Betaproteobacteria,4AAM0@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
k59_539885_1	402881.Plav_1344	3.99e-24	100.0	COG1309@1|root,COG1309@2|Bacteria,1N71J@1224|Proteobacteria,2UHJN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_657640_1	933262.AXAM01000008_gene1980	2.01e-62	211.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria,2MHM6@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	nifM	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
k59_1308290_1	2340.JV46_14240	9.32e-66	208.0	28Z54@1|root,2ZKXF@2|Bacteria,1RAVB@1224|Proteobacteria,1S46P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	2.3.1.109	ko:K00673	ko00330,ko01100,map00330,map01100	-	R00832	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	-
k59_368897_1	335659.S23_46090	3.46e-35	124.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2U72U@28211|Alphaproteobacteria,3JZX0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Iron-sulfur cluster assembly protein	mrp	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
k59_368897_2	768671.ThimaDRAFT_1716	1.57e-50	172.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1WWK5@135613|Chromatiales	135613|Chromatiales	O	FeS assembly protein SufD	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_1836516_1	2340.JV46_07410	4.49e-57	181.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,1J5QN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_1421118_1	1122244.AUGF01000029_gene1674	1.35e-30	118.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,3NJBR@468|Moraxellaceae	1236|Gammaproteobacteria	E	chorismate mutase	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
k59_1421118_2	585394.RHOM_06240	8e-06	48.1	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,248H9@186801|Clostridia	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase	pdxB	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_539903_1	1150626.PHAMO_40089	1.39e-55	183.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,2U2VJ@28211|Alphaproteobacteria,2JS16@204441|Rhodospirillales	204441|Rhodospirillales	T	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Peptidase_C14
k59_1071880_1	591158.SSMG_00399	2.81e-17	73.6	COG0257@1|root,COG0257@2|Bacteria,2GWMH@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
k59_1071880_2	313589.JNB_08124	1.14e-46	149.0	COG0361@1|root,COG0361@2|Bacteria,2IQ4B@201174|Actinobacteria,4FHB2@85021|Intrasporangiaceae	201174|Actinobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
k59_1836524_1	1249627.D779_3781	1.28e-27	109.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,1RM9Z@1236|Gammaproteobacteria,1WX87@135613|Chromatiales	135613|Chromatiales	S	PFAM Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_1836524_2	1286093.C266_13374	2.26e-38	144.0	COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,2VJ44@28216|Betaproteobacteria,1K0NB@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	pqiB	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_833497_1	765912.Thimo_2428	4.88e-139	422.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1WXPB@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_1007774_1	1267005.KB911255_gene2871	1.49e-104	315.0	COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2TS6U@28211|Alphaproteobacteria,3N6J6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	sun1	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F
k59_539909_1	323261.Noc_2340	1.69e-17	78.2	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1WVXJ@135613|Chromatiales	135613|Chromatiales	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
k59_481058_1	177437.HRM2_37210	1.22e-55	195.0	COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,42NGP@68525|delta/epsilon subdivisions,2WIZN@28221|Deltaproteobacteria,2MHUU@213118|Desulfobacterales	28221|Deltaproteobacteria	N	basal body rod protein	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
k59_253474_1	1049564.TevJSym_av00360	2.48e-111	343.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1J4UY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	general secretion pathway protein D	xcsD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_188050_1	1242864.D187_007631	2.16e-11	63.5	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,42VES@68525|delta/epsilon subdivisions,2WRSC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
k59_598243_1	469610.HMPREF0189_01276	2.25e-80	263.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria,1KJY8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_304912_1	290398.Csal_2868	4.65e-27	107.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1XIP5@135619|Oceanospirillales	135619|Oceanospirillales	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_304912_2	1049564.TevJSym_ag01050	5.24e-87	260.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1J5V6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_422318_1	471853.Bcav_2411	5.31e-111	335.0	COG0772@1|root,COG0772@2|Bacteria,2GKXP@201174|Actinobacteria	201174|Actinobacteria	D	Belongs to the SEDS family	ftsW	GO:0008150,GO:0040007	2.4.1.227	ko:K02563,ko:K03588	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011,ko02000,ko03036	2.A.103.1	GT28	-	FTSW_RODA_SPOVE
k59_1366469_2	765911.Thivi_3089	2.76e-110	326.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1WW00@135613|Chromatiales	135613|Chromatiales	H	Belongs to the ALAD family	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_309784_1	1299327.I546_1964	3.11e-56	187.0	COG3666@1|root,COG3666@2|Bacteria,2IA0I@201174|Actinobacteria,23AZU@1762|Mycobacteriaceae	201174|Actinobacteria	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1079580_1	471853.Bcav_3228	1.88e-41	140.0	COG0377@1|root,COG0377@2|Bacteria,2GJXR@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_1079580_2	935839.JAGJ01000018_gene2334	8.33e-52	166.0	COG0838@1|root,COG0838@2|Bacteria,2IKWT@201174|Actinobacteria,4F4GG@85017|Promicromonosporaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_1129579_1	593907.Celgi_1084	4.73e-20	99.0	COG1835@1|root,COG1835@2|Bacteria,2GKI5@201174|Actinobacteria,4F0NX@85016|Cellulomonadaceae	201174|Actinobacteria	I	PFAM acyltransferase 3	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_1718332_1	456442.Mboo_0883	1.3e-48	171.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,2N9FW@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b,tRNA_SAD
k59_1718332_2	456442.Mboo_0882	1.18e-08	54.3	COG0717@1|root,arCOG04048@2157|Archaea,2XTSH@28890|Euryarchaeota	28890|Euryarchaeota	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13,3.5.4.30	ko:K01494,ko:K09887	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325,R07307	RC00074,RC01825	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD,dUTPase
k59_309791_2	1318628.MARLIPOL_00583	5.29e-08	53.5	COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,464YJ@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	TPR_1,TPR_2,VWA_2
k59_603029_2	1121935.AQXX01000135_gene3757	3.59e-45	159.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1S1W6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
k59_1718335_1	1121940.AUDZ01000008_gene385	2.77e-52	173.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,1XHT3@135619|Oceanospirillales	135619|Oceanospirillales	H	COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2	moeB	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
k59_1254583_1	709032.Sulku_2190	1.6e-111	334.0	COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,42N5Y@68525|delta/epsilon subdivisions,2YN1U@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
k59_839006_1	105559.Nwat_0305	7.69e-13	67.8	COG3113@1|root,COG3113@2|Bacteria,1NGIE@1224|Proteobacteria,1SGH6@1236|Gammaproteobacteria,1X268@135613|Chromatiales	135613|Chromatiales	S	PFAM Sulfate transporter antisigma-factor antagonist STAS	-	-	-	ko:K07122	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	STAS_2
k59_839006_2	1117647.M5M_18500	1.65e-41	149.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,1RNPS@1236|Gammaproteobacteria,1J5QH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	COG2853 Surface lipoprotein	vacJ	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
k59_486551_1	485918.Cpin_6573	1.61e-20	90.5	COG0492@1|root,COG0492@2|Bacteria,4NDVS@976|Bacteroidetes,1INU1@117747|Sphingobacteriia	976|Bacteroidetes	O	Pyridine nucleotide-disulphide oxidoreductase	ypdA	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_3
k59_486551_2	745014.OMB55_00017990	4.73e-19	87.4	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,1RNA2@1236|Gammaproteobacteria,1J6SQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	H( )-stimulated, divalent metal cation uptake system	mntH	-	-	-	-	-	-	-	-	-	-	-	Nramp
k59_1426724_1	1411685.U062_01771	1.44e-50	165.0	COG0586@1|root,COG0586@2|Bacteria	2|Bacteria	S	FtsZ-dependent cytokinesis	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
k59_1130135_1	247634.GPB2148_1374	2.63e-60	205.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,1RNQ2@1236|Gammaproteobacteria,1J5GZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	GM	Polysaccharide biosynthesis protein	wbpM	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
k59_904989_1	590998.Celf_3030	6.13e-166	501.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4F0YF@85016|Cellulomonadaceae	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_545170_1	1026882.MAMP_00331	7.48e-66	218.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,45ZPV@72273|Thiotrichales	72273|Thiotrichales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_545170_2	1109445.AGSX01000004_gene739	3.58e-05	45.1	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,1Z17H@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0031224,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	iAF1260.b1912,iAPECO1_1312.APECO1_954,iB21_1397.B21_01866,iBWG_1329.BWG_1721,iE2348C_1286.E2348C_2030,iEC042_1314.EC042_2073,iEC55989_1330.EC55989_2132,iECABU_c1320.ECABU_c21710,iECBD_1354.ECBD_1731,iECB_1328.ECB_01877,iECDH10B_1368.ECDH10B_2053,iECDH1ME8569_1439.ECDH1ME8569_1852,iECD_1391.ECD_01877,iECED1_1282.ECED1_2177,iECH74115_1262.ECH74115_2684,iECIAI1_1343.ECIAI1_1996,iECIAI39_1322.ECIAI39_1143,iECNA114_1301.ECNA114_2003,iECO103_1326.ECO103_2168,iECO111_1330.ECO111_2492,iECO26_1355.ECO26_2804,iECOK1_1307.ECOK1_2029,iECP_1309.ECP_1852,iECS88_1305.ECS88_1966,iECSF_1327.ECSF_1764,iECSP_1301.ECSP_2516,iECUMN_1333.ECUMN_2204,iECs_1301.ECs2650,iETEC_1333.ETEC_2020,iEcDH1_1363.EcDH1_1734,iEcE24377_1341.EcE24377A_2145,iEcHS_1320.EcHS_A2010,iEcSMS35_1347.EcSMS35_1271,iEcolC_1368.EcolC_1727,iG2583_1286.G2583_2363,iJO1366.b1912,iJR904.b1912,iLF82_1304.LF82_1635,iNRG857_1313.NRG857_09550,iSDY_1059.SDY_1106,iSSON_1240.SSON_1206,iSbBS512_1146.SbBS512_E1039,iUMN146_1321.UM146_07620,iUMNK88_1353.UMNK88_2386,iUTI89_1310.UTI89_C2113,iY75_1357.Y75_RS10025,iYL1228.KPN_02410,iZ_1308.Z3000,ic_1306.c2325	CDP-OH_P_transf
k59_1719010_1	1121939.L861_13400	1.82e-67	213.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1XJ5P@135619|Oceanospirillales	135619|Oceanospirillales	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
k59_1777522_1	367299.JOEE01000002_gene2462	3.63e-42	148.0	COG0204@1|root,COG0204@2|Bacteria,2I8I4@201174|Actinobacteria,4FHMD@85021|Intrasporangiaceae	201174|Actinobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
k59_1777522_3	367299.JOEE01000002_gene2464	4.37e-40	141.0	COG0077@1|root,COG0077@2|Bacteria,2GJQ5@201174|Actinobacteria,4FG1M@85021|Intrasporangiaceae	201174|Actinobacteria	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
k59_83182_1	314278.NB231_08740	1.06e-28	114.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1WX09@135613|Chromatiales	135613|Chromatiales	P	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
k59_1130143_1	1089551.KE386572_gene1716	8.48e-72	226.0	COG0491@1|root,COG0491@2|Bacteria,1MY6G@1224|Proteobacteria,2TTBX@28211|Alphaproteobacteria,4BRAU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_310519_1	479434.Sthe_3287	1.98e-24	103.0	COG3642@1|root,COG3642@2|Bacteria,2G920@200795|Chloroflexi	200795|Chloroflexi	T	Domain of unknown function (DUF4032)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4032
k59_261014_2	1121127.JAFA01000002_gene1754	6.18e-55	176.0	COG1522@1|root,COG1522@2|Bacteria,1MZ9D@1224|Proteobacteria,2VSJ1@28216|Betaproteobacteria,1K775@119060|Burkholderiaceae	28216|Betaproteobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
k59_721869_1	324602.Caur_3313	4.95e-17	84.7	COG4587@1|root,COG4587@2|Bacteria,2G9N0@200795|Chloroflexi,37604@32061|Chloroflexia	32061|Chloroflexia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
k59_839032_1	1124983.PFLCHA0_c27920	4.01e-31	127.0	COG0457@1|root,COG0457@2|Bacteria,1MXK4@1224|Proteobacteria,1RNFM@1236|Gammaproteobacteria,1YUIS@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Oxygen tolerance	batD	-	-	-	-	-	-	-	-	-	-	-	BatD
k59_486578_1	1187851.A33M_3785	2.23e-66	210.0	COG0500@1|root,COG2226@2|Bacteria,1RB4F@1224|Proteobacteria,2U613@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25,Ubie_methyltran
k59_134993_1	344747.PM8797T_22808	3.03e-18	89.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,2IXTY@203682|Planctomycetes	203682|Planctomycetes	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
k59_1543077_1	396588.Tgr7_0707	3.14e-58	193.0	COG3408@1|root,COG3408@2|Bacteria,1R3W7@1224|Proteobacteria,1RVZH@1236|Gammaproteobacteria,1X040@135613|Chromatiales	135613|Chromatiales	G	Alkaline and neutral invertase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_100
k59_603731_1	1134445.AJJM01000079_gene524	5.6e-40	142.0	COG0259@1|root,COG0259@2|Bacteria,2GJCR@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0010181,GO:0016491,GO:0016614,GO:0016899,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032553,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042803,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2607	PNP_phzG_C,Putative_PNPOx
k59_603731_2	391623.TERMP_00427	6.83e-05	43.5	COG1605@1|root,arCOG02098@2157|Archaea,2Y6KA@28890|Euryarchaeota,244TS@183968|Thermococci	183968|Thermococci	E	Chorismate mutase type II	-	-	5.4.99.5	ko:K04093	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2
k59_721883_1	324057.Pjdr2_4489	0.000118	44.3	COG1396@1|root,COG1396@2|Bacteria,1UV7I@1239|Firmicutes,4I3X6@91061|Bacilli,270P1@186822|Paenibacillaceae	91061|Bacilli	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
k59_261048_1	1038869.AXAN01000016_gene1411	4.15e-52	181.0	COG1158@1|root,COG3064@1|root,COG1158@2|Bacteria,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,2VKTY@28216|Betaproteobacteria,1K11H@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
k59_1601335_1	420662.Mpe_A0824	1.42e-49	166.0	COG0457@1|root,COG0457@2|Bacteria,1R3PT@1224|Proteobacteria,2VN88@28216|Betaproteobacteria,1KKRT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1601335_2	522306.CAP2UW1_3343	2.32e-17	82.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,2VIJ1@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
k59_1543080_1	1906.SFRA_31355	4.57e-45	161.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria	201174|Actinobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_376809_1	1121943.KB899998_gene1560	1.44e-27	111.0	COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,1RQ6M@1236|Gammaproteobacteria,1XJNR@135619|Oceanospirillales	135619|Oceanospirillales	I	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
k59_721886_1	1379270.AUXF01000002_gene1585	4.78e-54	195.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
k59_1316245_1	743299.Acife_2010	3.58e-108	327.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,2NC4N@225057|Acidithiobacillales	225057|Acidithiobacillales	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	-	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
k59_1080557_2	472759.Nhal_1615	6.31e-32	123.0	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,1RP1B@1236|Gammaproteobacteria,1WZVK@135613|Chromatiales	135613|Chromatiales	C	Prokaryotic cytochrome b561	-	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
k59_1601345_1	439235.Dalk_2368	1.09e-14	66.6	COG1592@1|root,COG1592@2|Bacteria	2|Bacteria	C	Rubrerythrin	-	-	-	ko:K19824	-	-	-	-	ko00000	-	-	-	FeThRed_B,Rubrerythrin
k59_1601345_2	573370.DMR_17610	4.5e-70	213.0	COG2033@1|root,COG2033@2|Bacteria,1RHE0@1224|Proteobacteria,42SB9@68525|delta/epsilon subdivisions,2WP2D@28221|Deltaproteobacteria,2MBEZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Desulfoferrodoxin ferrous iron-binding region	dfx	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
k59_1426781_1	1120977.JHUX01000003_gene910	6.79e-36	134.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,3NJN7@468|Moraxellaceae	1236|Gammaproteobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_1426781_2	1123256.KB907926_gene1007	3.47e-31	114.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria,1X6P1@135614|Xanthomonadales	135614|Xanthomonadales	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
k59_839064_1	652103.Rpdx1_0162	1.47e-131	391.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3JSCZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme	acsf	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_1316258_1	1150864.MILUP08_43923	6.64e-122	361.0	2EIPT@1|root,33CF7@2|Bacteria,2GWUN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1130189_1	595460.RRSWK_01367	9.98e-60	201.0	COG5361@1|root,COG5361@2|Bacteria,2IYY0@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_83272_1	1198232.CYCME_1738	3.17e-65	229.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,45ZUT@72273|Thiotrichales	72273|Thiotrichales	S	DNA internalization-related competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_964097_1	1380354.JIAN01000005_gene2540	1.27e-73	227.0	COG0518@1|root,COG0518@2|Bacteria,2GKS1@201174|Actinobacteria,4F29U@85016|Cellulomonadaceae	201174|Actinobacteria	F	Glutamine amidotransferase class-I	guaA_2	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
k59_964097_2	935839.JAGJ01000014_gene3571	1.49e-13	69.3	COG0454@1|root,COG0456@2|Bacteria,2I8J8@201174|Actinobacteria,4F4C6@85017|Promicromonosporaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1191795_1	558884.JRGM01000131_gene459	6.15e-38	142.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1Y3X8@135624|Aeromonadales	135624|Aeromonadales	M	Transglycosylase SLT domain	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_1426787_1	1033802.SSPSH_000349	1.89e-143	421.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_83273_2	1095767.CAHD01000204_gene2226	2.41e-58	191.0	COG0169@1|root,COG0169@2|Bacteria,2GPQQ@201174|Actinobacteria,4F0DS@85016|Cellulomonadaceae	201174|Actinobacteria	E	PFAM Shikimate dehydrogenase substrate binding domain protein	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2552c	Shikimate_DH,Shikimate_dh_N
k59_1367208_1	768671.ThimaDRAFT_3829	4.58e-128	377.0	COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1WXET@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_8,RnfC_N,SLBB
k59_1012415_1	1121396.KB893112_gene2008	4.98e-83	265.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria,2MIMQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3394)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_1426792_1	471853.Bcav_1943	5.2e-83	265.0	COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria	201174|Actinobacteria	E	amino acid	ydaO	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_27193_1	573061.Clocel_2755	1.82e-28	118.0	COG1032@1|root,COG1032@2|Bacteria,1TR2C@1239|Firmicutes,248HM@186801|Clostridia,36DQF@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_1543116_1	102129.Lepto7375DRAFT_4164	4.84e-15	78.6	COG1792@1|root,COG1792@2|Bacteria,1G1VN@1117|Cyanobacteria,1H7BB@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Rod shape-determining protein MreC	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
k59_1316287_1	1224136.AMFN01000004_gene1706	2.38e-76	238.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,282IC@191675|unclassified Enterobacteriaceae	1236|Gammaproteobacteria	F	Belongs to the CarA family	carA	GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1950,iUTI89_1310.UTI89_C0036,ic_1306.c0040	CPSase_sm_chain,GATase
k59_777444_1	1122132.AQYH01000005_gene496	2.56e-90	270.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2TRSG@28211|Alphaproteobacteria,4B9M6@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_261119_1	1218074.BAXZ01000004_gene1162	3.64e-119	360.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,1K24M@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23,OmpA
k59_1844469_1	706587.Desti_1174	4.01e-17	79.3	COG2204@1|root,COG2204@2|Bacteria,1RKC4@1224|Proteobacteria,42SJ3@68525|delta/epsilon subdivisions,2WPI1@28221|Deltaproteobacteria,2MRU7@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_964132_1	1380391.JIAS01000019_gene1349	7.58e-64	203.0	COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2U62V@28211|Alphaproteobacteria,2JRXQ@204441|Rhodospirillales	204441|Rhodospirillales	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_721928_1	572477.Alvin_1406	3.31e-86	269.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1WWIH@135613|Chromatiales	135613|Chromatiales	CP	PFAM NADH Ubiquinone plastoquinone	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
k59_839106_1	1123228.AUIH01000010_gene4002	4.72e-60	196.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,1RSCP@1236|Gammaproteobacteria,1XPHQ@135619|Oceanospirillales	135619|Oceanospirillales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_427888_1	765912.Thimo_1650	2.29e-52	172.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1WWVP@135613|Chromatiales	135613|Chromatiales	C	PFAM Cytochrome C1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
k59_905122_1	1123367.C666_16015	2.97e-20	85.9	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2VHT5@28216|Betaproteobacteria,2KVCY@206389|Rhodocyclales	206389|Rhodocyclales	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_905122_2	983917.RGE_02170	3.77e-34	126.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,2VMNV@28216|Betaproteobacteria,1KJZV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
k59_1426830_2	765912.Thimo_1224	1.36e-21	88.6	COG2149@1|root,COG2149@2|Bacteria,1NGFR@1224|Proteobacteria,1SHGT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF202)	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
k59_376903_1	1304885.AUEY01000022_gene3387	5.32e-23	94.4	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,42TVX@68525|delta/epsilon subdivisions,2WP4F@28221|Deltaproteobacteria,2MKAW@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM Transglycosylase SLT domain	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	DUF4124,SLT
k59_376903_2	9371.XP_004706482.1	1.28e-22	99.0	COG0296@1|root,KOG0470@2759|Eukaryota,3AV51@33154|Opisthokonta,3BBZM@33208|Metazoa,3CUA6@33213|Bilateria,481TA@7711|Chordata,48W51@7742|Vertebrata,3J7GM@40674|Mammalia,34Y5Y@311790|Afrotheria	33208|Metazoa	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	GBE1	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0007275,GO:0007568,GO:0008150,GO:0008152,GO:0008340,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0010259,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0030246,GO:0032501,GO:0032502,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0048856,GO:0055114,GO:0071704,GO:1901576	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_1316333_1	177437.HRM2_42990	2.35e-26	112.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,42NYJ@68525|delta/epsilon subdivisions,2WKWS@28221|Deltaproteobacteria,2MKJJ@213118|Desulfobacterales	28221|Deltaproteobacteria	GT	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_1852389_1	1049564.TevJSym_ap00260	1.93e-53	187.0	COG0637@1|root,COG1234@1|root,COG0637@2|Bacteria,COG1234@2|Bacteria,1PPRD@1224|Proteobacteria,1RRV8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Beta-lactamase superfamily domain	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	CLP1_P,Lactamase_B,Lactamase_B_2
k59_36204_1	471853.Bcav_1931	1.39e-43	154.0	COG1524@1|root,COG1524@2|Bacteria,2GISU@201174|Actinobacteria	201174|Actinobacteria	S	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
k59_1495820_1	1179773.BN6_17210	4.18e-06	47.0	COG3832@1|root,COG3832@2|Bacteria,2HS09@201174|Actinobacteria,4EBPC@85010|Pseudonocardiales	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
k59_1495820_2	1509405.GV67_08075	0.000231	45.4	COG0640@1|root,COG0640@2|Bacteria,1RGYC@1224|Proteobacteria,2UA77@28211|Alphaproteobacteria,4BEUD@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	MA20_01010	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
k59_316005_1	1173028.ANKO01000006_gene2044	5e-140	402.0	COG0451@1|root,COG0451@2|Bacteria,1G44E@1117|Cyanobacteria,1HAIG@1150|Oscillatoriales	1117|Cyanobacteria	M	Polysaccharide biosynthesis protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_1372135_1	509190.Cseg_3670	2.29e-59	201.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2TQSU@28211|Alphaproteobacteria,2KF4N@204458|Caulobacterales	204458|Caulobacterales	P	Ferrous iron transport protein B	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_1372135_2	1123255.JHYS01000004_gene901	2.64e-12	63.2	COG1918@1|root,COG1918@2|Bacteria,1NASN@1224|Proteobacteria,2VVSY@28216|Betaproteobacteria,4AFGG@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM FeoA family protein	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
k59_269759_1	367299.JOEE01000003_gene2743	1.62e-71	226.0	COG1122@1|root,COG1122@2|Bacteria,2GMK1@201174|Actinobacteria,4FF62@85021|Intrasporangiaceae	201174|Actinobacteria	P	ABC transporter (Permease)	-	-	-	ko:K16927	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.32	-	-	ECF_trnsprt
k59_491835_1	572477.Alvin_2131	2.56e-125	377.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_384642_1	1192868.CAIU01000019_gene2711	2.63e-12	65.5	COG0454@1|root,COG0456@2|Bacteria,1MZUT@1224|Proteobacteria,2UC9I@28211|Alphaproteobacteria,43JNI@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_384642_2	411684.HPDFL43_06902	2.08e-107	327.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2TRWK@28211|Alphaproteobacteria,43I12@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_1324139_1	713587.THITH_10595	3.28e-127	368.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1S1ME@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	frdB	-	1.3.5.4	ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
k59_1432153_1	717773.Thicy_0346	6.1e-16	88.2	COG2911@1|root,COG3210@1|root,COG3595@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG3595@2|Bacteria,1P8N9@1224|Proteobacteria,1RYB2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_384646_2	395493.BegalDRAFT_0524	1.85e-41	140.0	COG2010@1|root,COG2010@2|Bacteria,1N1Z3@1224|Proteobacteria,1S8J5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Domain of unknown function (DUF1924)	shp	-	-	-	-	-	-	-	-	-	-	-	DUF1924
k59_384646_3	1123355.JHYO01000004_gene2498	5.32e-27	108.0	COG3658@1|root,COG3658@2|Bacteria,1N28F@1224|Proteobacteria,2UCXG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Dihaem cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	DHC
k59_1324144_1	1713.JOFV01000001_gene2061	2.92e-58	190.0	COG1834@1|root,COG1834@2|Bacteria,2GNTN@201174|Actinobacteria,4F2BI@85016|Cellulomonadaceae	201174|Actinobacteria	E	Amidinotransferase	-	GO:0003674,GO:0003824,GO:0016403,GO:0016787,GO:0016810,GO:0016813	-	-	-	-	-	-	-	-	-	-	Amidinotransf
k59_91169_1	261292.Nit79A3_1788	3.84e-79	251.0	28HU5@1|root,2Z80X@2|Bacteria,1R55N@1224|Proteobacteria,2VI32@28216|Betaproteobacteria,372Y4@32003|Nitrosomonadales	28216|Betaproteobacteria	S	TIGRFAM TIGR03790 family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_316021_1	879212.DespoDRAFT_00799	2.11e-17	82.0	COG0680@1|root,COG0680@2|Bacteria,1RIDR@1224|Proteobacteria,42SRR@68525|delta/epsilon subdivisions,2WPGX@28221|Deltaproteobacteria,2MK9E@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
k59_316021_2	765912.Thimo_1706	2.45e-12	61.6	COG0298@1|root,COG0298@2|Bacteria,1QKV6@1224|Proteobacteria,1SE6V@1236|Gammaproteobacteria,1WZDC@135613|Chromatiales	135613|Chromatiales	O	PFAM hydrogenase expression formation protein (HUPF HYPC)	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
k59_550397_1	713587.THITH_09195	5.6e-50	168.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria,1WX0B@135613|Chromatiales	135613|Chromatiales	O	heat shock protein DnaJ	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
k59_91171_1	305700.B447_16016	1.65e-46	154.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,2VHCP@28216|Betaproteobacteria,2KUBB@206389|Rhodocyclales	206389|Rhodocyclales	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_91171_2	1123368.AUIS01000013_gene872	4.18e-42	140.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,1S973@1236|Gammaproteobacteria,2ND3N@225057|Acidithiobacillales	225057|Acidithiobacillales	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
k59_971976_1	1286106.MPL1_03678	6.24e-75	230.0	COG0235@1|root,COG0235@2|Bacteria,1QAVF@1224|Proteobacteria,1RW3I@1236|Gammaproteobacteria,4628Z@72273|Thiotrichales	72273|Thiotrichales	G	PFAM Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
k59_971976_2	1415779.JOMH01000001_gene1878	4.76e-25	97.1	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,1X6M4@135614|Xanthomonadales	135614|Xanthomonadales	U	General secretion pathway protein	xcsG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
k59_971983_2	1304885.AUEY01000151_gene646	1.01e-05	48.9	2EF8R@1|root,32W7B@2|Bacteria,1N6JW@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_550403_1	765910.MARPU_10730	1.87e-104	315.0	COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1WXET@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_8,RnfC_N,SLBB
k59_1016880_1	1242864.D187_006642	6.59e-10	65.1	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2X791@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_4,Response_reg
k59_1724422_1	1095769.CAHF01000017_gene17	2.06e-84	269.0	COG4257@1|root,COG4257@2|Bacteria,1R448@1224|Proteobacteria,2W139@28216|Betaproteobacteria	28216|Betaproteobacteria	V	COG4257 Streptogramin lyase	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	CarboxypepD_reg
k59_140117_1	28072.Nos7524_1286	2.02e-19	96.3	COG2931@1|root,COG3210@1|root,COG3291@1|root,COG3595@1|root,COG4070@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG3595@2|Bacteria,COG4070@2|Bacteria,1GHDQ@1117|Cyanobacteria,1HUA0@1161|Nostocales	1117|Cyanobacteria	Q	Domain of unknown function (DUF4114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114
k59_726828_1	670307.HYPDE_37743	1.61e-52	180.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,2TSQM@28211|Alphaproteobacteria,3N66B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
k59_269799_1	386456.JQKN01000007_gene3253	6.33e-19	80.9	COG2092@1|root,arCOG01988@2157|Archaea,2XYNW@28890|Euryarchaeota,23P7D@183925|Methanobacteria	183925|Methanobacteria	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
k59_1606268_1	42256.RradSPS_0888	7.65e-67	218.0	COG1115@1|root,COG1115@2|Bacteria,2GIU2@201174|Actinobacteria	201174|Actinobacteria	E	amino acid carrier protein	alaP	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_1372166_1	631362.Thi970DRAFT_03026	7.7e-98	301.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXFK@135613|Chromatiales	135613|Chromatiales	GM	nucleoside-diphosphate sugar epimerase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
k59_1372166_2	1123401.JHYQ01000018_gene2341	1.68e-09	58.9	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RY2H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GM	PFAM NAD dependent epimerase dehydratase family	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10
k59_1135273_1	622637.KE124774_gene854	6.63e-53	181.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TT6V@28211|Alphaproteobacteria,36YID@31993|Methylocystaceae	28211|Alphaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	FliO,Voltage_CLC
k59_609105_1	1049564.TevJSym_aw00530	1.71e-57	187.0	COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,1RMYW@1236|Gammaproteobacteria,1J68A@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	N	Role in flagellar biosynthesis	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
k59_140128_1	595536.ADVE02000001_gene3062	1.66e-66	214.0	COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,2TQR3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_1548098_1	1269813.ATUL01000001_gene1015	5.29e-39	141.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,1WWQP@135613|Chromatiales	135613|Chromatiales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
k59_1548098_2	765912.Thimo_1648	1.26e-72	223.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria,1WWVC@135613|Chromatiales	135613|Chromatiales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
k59_91221_1	870187.Thini_4223	8.05e-88	274.0	COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,4601J@72273|Thiotrichales	72273|Thiotrichales	E	Sodium:alanine symporter family	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_198718_1	768671.ThimaDRAFT_1132	6.83e-25	97.4	COG4319@1|root,COG4319@2|Bacteria,1NEUY@1224|Proteobacteria,1S6AP@1236|Gammaproteobacteria,1WYK1@135613|Chromatiales	135613|Chromatiales	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
k59_198718_2	765912.Thimo_3444	1.48e-21	93.6	COG0071@1|root,COG0071@2|Bacteria,1N3MV@1224|Proteobacteria,1SC0T@1236|Gammaproteobacteria,1WYX0@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
k59_91232_1	933262.AXAM01000034_gene1556	3.96e-24	100.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,42NF0@68525|delta/epsilon subdivisions,2WIJK@28221|Deltaproteobacteria,2MHPA@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
k59_91232_2	1121405.dsmv_3255	2.36e-30	119.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2MIPH@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_668382_1	1283300.ATXB01000001_gene664	6.58e-104	314.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria,1XFWC@135618|Methylococcales	135618|Methylococcales	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	hDGE_amylase
k59_1197164_1	1265505.ATUG01000002_gene2129	5.99e-122	353.0	COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,42PAQ@68525|delta/epsilon subdivisions,2WKN9@28221|Deltaproteobacteria,2MKJR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM amidohydrolase 2	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_198727_1	864069.MicloDRAFT_00013910	1.52e-23	104.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,1JR57@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
k59_1261437_2	1302286.BAOT01000003_gene453	7.4e-13	69.7	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,4HCDR@91061|Bacilli,3F4UI@33958|Lactobacillaceae	91061|Bacilli	T	phosphatase	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
k59_491886_1	98439.AJLL01000090_gene95	1.74e-13	75.5	COG3240@1|root,COG3240@2|Bacteria,1G2TV@1117|Cyanobacteria,1JKZ2@1189|Stigonemataceae	1117|Cyanobacteria	I	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,Lipase_GDSL,VPEP
k59_1495898_1	633149.Bresu_0545	1.79e-24	99.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,2TRPN@28211|Alphaproteobacteria,2KFSZ@204458|Caulobacterales	204458|Caulobacterales	IQ	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_448915_1	367299.JOEE01000002_gene2640	2.96e-91	275.0	COG0706@1|root,COG0706@2|Bacteria,2GJBU@201174|Actinobacteria,4FFAN@85021|Intrasporangiaceae	201174|Actinobacteria	U	Preprotein translocase subunit YidC	yidC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
k59_1387853_1	765698.Mesci_1031	2.06e-90	278.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,43J03@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Ammonium Transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_1278964_1	187272.Mlg_0797	1.82e-74	250.0	28JMP@1|root,2Z9E6@2|Bacteria,1MYTR@1224|Proteobacteria,1RQ40@1236|Gammaproteobacteria,1X12Y@135613|Chromatiales	135613|Chromatiales	S	Capsule assembly protein Wzi	-	-	-	-	-	-	-	-	-	-	-	-	Caps_assemb_Wzi
k59_1278964_2	667632.KB890164_gene1663	4.13e-05	45.8	2B5YT@1|root,31YUV@2|Bacteria,1N69D@1224|Proteobacteria,2W3HN@28216|Betaproteobacteria,1K8GD@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3088
k59_410244_1	519989.ECTPHS_03879	1.38e-59	194.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1WVY1@135613|Chromatiales	135613|Chromatiales	HJ	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
k59_410244_2	187272.Mlg_0355	1e-58	186.0	COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S4CZ@1236|Gammaproteobacteria,1WY6S@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_743175_1	925409.KI911562_gene2869	0.000224	46.6	COG2227@1|root,COG2227@2|Bacteria,4PKUR@976|Bacteroidetes,1J0TH@117747|Sphingobacteriia	976|Bacteroidetes	H	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25,Methyltransf_31
k59_1149106_1	472759.Nhal_1522	5.93e-32	120.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,1RMFI@1236|Gammaproteobacteria,1WX5G@135613|Chromatiales	135613|Chromatiales	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
k59_1149106_2	748247.AZKH_1551	6.64e-52	166.0	COG1403@1|root,COG1403@2|Bacteria,1RGZQ@1224|Proteobacteria,2VSZE@28216|Betaproteobacteria,2KWRE@206389|Rhodocyclales	206389|Rhodocyclales	L	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH
k59_156258_1	1205908.AKXW01000122_gene344	7.4e-19	87.0	COG0786@1|root,COG0786@2|Bacteria,1MVBC@1224|Proteobacteria,1RP0S@1236|Gammaproteobacteria,1XUE5@135623|Vibrionales	135623|Vibrionales	P	Catalyzes the sodium-dependent transport of glutamate	-	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
k59_410250_2	1121396.KB893095_gene4378	5.4e-41	142.0	COG3090@1|root,COG3090@2|Bacteria,1MZNX@1224|Proteobacteria,42TZJ@68525|delta/epsilon subdivisions,2WQB8@28221|Deltaproteobacteria,2MKJH@213118|Desulfobacterales	28221|Deltaproteobacteria	G	PFAM Tripartite ATP-independent periplasmic transporter, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_997625_1	767434.Fraau_2673	1.12e-29	114.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1X3PE@135614|Xanthomonadales	135614|Xanthomonadales	F	Belongs to the SAICAR synthetase family	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
k59_290680_1	765914.ThisiDRAFT_1643	2.11e-71	242.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1WWGW@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM ATP-dependent helicase HrpA	-	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_448939_1	207559.Dde_2855	3.42e-47	166.0	COG0659@1|root,COG0659@2|Bacteria,1MX1U@1224|Proteobacteria,42Q8Y@68525|delta/epsilon subdivisions,2WK07@28221|Deltaproteobacteria,2M9WF@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Sulphate transporter	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	MFS_MOT1
k59_1621849_2	335543.Sfum_2166	3.45e-71	220.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,42NZY@68525|delta/epsilon subdivisions,2WJDY@28221|Deltaproteobacteria,2MQBN@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1885	PdxJ
k59_58071_1	1380391.JIAS01000013_gene3382	2.72e-93	285.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,2JPRX@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.18	ko:K00822	ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100	-	R00907,R04187	RC00008,RC00062,RC00160	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_997644_1	926560.KE387026_gene4175	2.17e-05	45.4	COG0842@1|root,COG0842@2|Bacteria,1WM4H@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
k59_332067_1	768671.ThimaDRAFT_4484	1.94e-45	157.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1Q7PK@1224|Proteobacteria,1RSF0@1236|Gammaproteobacteria,1WWA3@135613|Chromatiales	135613|Chromatiales	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_29,HTH_33
k59_332067_2	519989.ECTPHS_14004	3.52e-30	118.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1WVZP@135613|Chromatiales	135613|Chromatiales	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_507652_1	391613.RTM1035_20531	2.45e-27	111.0	COG0420@1|root,COG0420@2|Bacteria,1MY4X@1224|Proteobacteria,2TRGE@28211|Alphaproteobacteria,46RCW@74030|Roseovarius	28211|Alphaproteobacteria	L	DNA repair exonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_1513172_1	768671.ThimaDRAFT_3845	8.07e-80	265.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1WXJB@135613|Chromatiales	135613|Chromatiales	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_332076_2	396588.Tgr7_1267	1.21e-57	191.0	COG0247@1|root,COG1145@1|root,COG0247@2|Bacteria,COG1145@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1WWK6@135613|Chromatiales	135613|Chromatiales	C	PFAM Cysteine-rich	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_997656_1	246200.SPO2214	5.15e-115	343.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria,4NAWB@97050|Ruegeria	1224|Proteobacteria	P	hmm pf00884	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
k59_1279006_1	880072.Desac_1774	9.36e-83	268.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WIXV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GT	Pyruvate phosphate dikinase PEP	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_1563683_1	1116472.MGMO_105c00580	1.33e-95	296.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1XER8@135618|Methylococcales	135618|Methylococcales	JKL	DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation	deaD	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
k59_410296_1	1286106.MPL1_02528	9.16e-06	47.4	COG1148@1|root,COG1149@1|root,COG1148@2|Bacteria,COG1149@2|Bacteria,1QUQG@1224|Proteobacteria,1T214@1236|Gammaproteobacteria,461U9@72273|Thiotrichales	72273|Thiotrichales	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3306,Fer4
k59_410296_2	945550.VISI1226_20949	7.48e-40	142.0	COG3381@1|root,COG3381@2|Bacteria,1N49B@1224|Proteobacteria,1S958@1236|Gammaproteobacteria,1Y2A7@135623|Vibrionales	135623|Vibrionales	S	Nitrate reductase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
k59_1222996_1	596152.DesU5LDRAFT_0983	4.58e-10	59.7	COG4191@1|root,COG4191@2|Bacteria,1NC2K@1224|Proteobacteria,42WDG@68525|delta/epsilon subdivisions,2WRNM@28221|Deltaproteobacteria,2MB0P@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HisKA
k59_1222996_2	671143.DAMO_3123	7.28e-12	67.0	COG2204@1|root,COG2204@2|Bacteria,2NQHI@2323|unclassified Bacteria	2|Bacteria	T	Sigma-54 interaction domain	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1693275_1	1126627.BAWE01000005_gene6111	3.36e-41	162.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_802487_1	933262.AXAM01000003_gene2874	1.29e-17	84.0	COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,42NJB@68525|delta/epsilon subdivisions,2WM62@28221|Deltaproteobacteria,2MI1G@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2333)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2333
k59_870858_1	715451.ambt_04460	2.18e-07	52.4	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,4643F@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432	PseudoU_synth_2,S4
k59_1751320_2	292415.Tbd_1990	1.08e-76	232.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2VH1H@28216|Betaproteobacteria,1KRJT@119069|Hydrogenophilales	119069|Hydrogenophilales	E	ACT domain	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5,ALS_ss_C
k59_1694772_1	748658.KB907313_gene2189	5.95e-52	179.0	COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1WWZ8@135613|Chromatiales	135613|Chromatiales	S	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_1634036_1	1226994.AMZB01000110_gene1995	1.94e-57	193.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1YFA7@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	LysM domain	lysM	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_695390_1	765911.Thivi_3668	6.42e-106	318.0	COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,1RP9M@1236|Gammaproteobacteria,1X1C2@135613|Chromatiales	135613|Chromatiales	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_167926_1	935839.JAGJ01000032_gene38	9.54e-101	303.0	COG5361@1|root,COG5361@2|Bacteria,2GKTA@201174|Actinobacteria,4F5DW@85017|Promicromonosporaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_576550_1	1254432.SCE1572_07785	3.82e-52	176.0	COG2006@1|root,COG2006@2|Bacteria,1QMGX@1224|Proteobacteria,42PRJ@68525|delta/epsilon subdivisions,2WMFN@28221|Deltaproteobacteria,2Z073@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
k59_1694780_1	1335757.SPICUR_06190	2.59e-68	218.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,1WW0G@135613|Chromatiales	135613|Chromatiales	J	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
k59_1045179_1	1279038.KB907361_gene2159	2.74e-56	184.0	COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,2TT8X@28211|Alphaproteobacteria,2JQQR@204441|Rhodospirillales	204441|Rhodospirillales	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	-	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
k59_225998_1	768706.Desor_1203	4.11e-54	189.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,260BP@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_1751335_1	270374.MELB17_11233	2.96e-56	192.0	COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,1RMWX@1236|Gammaproteobacteria,46570@72275|Alteromonadaceae	1236|Gammaproteobacteria	N	Flagellar hook protein FlgE	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
k59_1459683_1	880072.Desac_2373	5.99e-41	141.0	COG3009@1|root,COG3009@2|Bacteria,1N8BW@1224|Proteobacteria,42UW2@68525|delta/epsilon subdivisions,2WQFD@28221|Deltaproteobacteria,2MS52@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K09857	-	-	-	-	ko00000	-	-	-	ABC_trans_aux
k59_167965_1	555778.Hneap_1402	1.44e-67	228.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_226023_2	756272.Plabr_0767	1.76e-39	149.0	COG5361@1|root,COG5361@2|Bacteria,2IZB8@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254,Neur_chan_LBD,Neur_chan_memb
k59_167966_1	882378.RBRH_04047	3.01e-15	73.2	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2VU6T@28216|Betaproteobacteria,1K7SV@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
k59_167966_2	1454004.AW11_02355	7.78e-40	142.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,2VHKV@28216|Betaproteobacteria,1KQSG@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_1159126_1	631362.Thi970DRAFT_00090	2.59e-86	281.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1WVW8@135613|Chromatiales	135613|Chromatiales	EF	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_872527_1	439235.Dalk_1444	1.46e-27	111.0	COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,42NTH@68525|delta/epsilon subdivisions,2WJ8N@28221|Deltaproteobacteria,2MIMX@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1634086_1	471853.Bcav_1752	4.38e-59	191.0	COG1159@1|root,COG1159@2|Bacteria,2GJJE@201174|Actinobacteria	201174|Actinobacteria	M	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
k59_695437_1	644801.Psest_2528	6.69e-51	167.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,1RPU6@1236|Gammaproteobacteria,1Z22V@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	C	COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
k59_695437_2	1265313.HRUBRA_02085	1.25e-14	67.4	COG4736@1|root,COG4736@2|Bacteria,1NGAN@1224|Proteobacteria,1SGJ2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Cbb3-type cytochrome oxidase, subunit 3	ccoQ	-	-	ko:K00407	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixQ
k59_1224572_1	187272.Mlg_0992	1.92e-21	92.8	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,1SYDF@1236|Gammaproteobacteria,1WXZ3@135613|Chromatiales	135613|Chromatiales	NT	PFAM CheW domain protein	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
k59_1224572_2	1121481.AUAS01000002_gene3305	1.24e-20	92.8	COG0642@1|root,COG0745@1|root,COG4251@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,4NE3J@976|Bacteroidetes,47JCX@768503|Cytophagia	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k59_1694828_1	477228.YO5_09355	2.87e-94	300.0	COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,1RPD2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C552,Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_1,TPR_11,TPR_16,TPR_19,TPR_8
k59_754980_1	925409.KI911562_gene577	2.83e-08	57.4	COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes,1IP8S@117747|Sphingobacteriia	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_754980_2	745411.B3C1_11334	1.5e-23	100.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5K5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_754985_2	768671.ThimaDRAFT_3082	9.05e-51	173.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1WVX9@135613|Chromatiales	135613|Chromatiales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_1634118_1	1267005.KB911257_gene786	3.39e-73	239.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2TU4K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	nitric oxide reductase activation protein	norD	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_2
k59_168006_1	519989.ECTPHS_01394	2.34e-29	115.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1WWQH@135613|Chromatiales	135613|Chromatiales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	ko:K13283	-	-	-	-	ko00000,ko02000	2.A.4.7.1	-	-	Cation_efflux,ZT_dimer
k59_168006_2	1123400.KB904746_gene1263	8.77e-24	92.4	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	tusA	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
k59_168006_3	1469245.JFBG01000074_gene99	5.34e-30	116.0	COG0482@1|root,COG0482@2|Bacteria,1QV6H@1224|Proteobacteria,1RQSV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	ThiI,tRNA_Me_trans
k59_1634127_1	713587.THITH_04050	1.27e-129	383.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1WW79@135613|Chromatiales	135613|Chromatiales	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
k59_635670_1	396588.Tgr7_1267	2.76e-104	314.0	COG0247@1|root,COG1145@1|root,COG0247@2|Bacteria,COG1145@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1WWK6@135613|Chromatiales	135613|Chromatiales	C	PFAM Cysteine-rich	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_1399448_1	694429.Pyrfu_1342	2.64e-07	53.1	COG0434@1|root,arCOG01982@2157|Archaea,2XQMB@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM photosystem I assembly BtpA	-	-	-	ko:K06971	-	-	-	-	ko00000	-	-	-	BtpA
k59_1399448_2	472759.Nhal_3762	1.65e-14	73.2	COG5319@1|root,COG5319@2|Bacteria,1RKDX@1224|Proteobacteria,1S6XI@1236|Gammaproteobacteria,1WYMU@135613|Chromatiales	135613|Chromatiales	S	Regulatory protein, FmdB	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
k59_1399453_1	42256.RradSPS_3087	2.12e-06	48.1	COG0695@1|root,COG0695@2|Bacteria,2HPAH@201174|Actinobacteria,4CQNW@84995|Rubrobacteria	84995|Rubrobacteria	O	Glutaredoxin	-	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
k59_1399453_2	225117.XP_009346841.1	1.68e-16	79.7	COG1011@1|root,KOG3085@2759|Eukaryota,37PXI@33090|Viridiplantae,3GGW6@35493|Streptophyta,4JJ2X@91835|fabids	35493|Streptophyta	S	Haloacid dehalogenase-like hydrolase	-	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009507,GO:0009536,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043621,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0090711	3.1.3.102,3.1.3.104	ko:K20860	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00548,R07280	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2
k59_755042_1	1266925.JHVX01000007_gene2379	4.31e-93	291.0	COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,2VPI8@28216|Betaproteobacteria,372CD@32003|Nitrosomonadales	28216|Betaproteobacteria	I	PFAM Prenyltransferase squalene oxidase	shc	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
k59_226101_1	1304865.JAGF01000001_gene659	1.71e-63	210.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,2H7WY@201174|Actinobacteria,4F10M@85016|Cellulomonadaceae	201174|Actinobacteria	P	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	cdr	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
k59_226101_2	1356852.N008_09220	9.49e-10	59.7	COG0476@1|root,COG0476@2|Bacteria,4NFUD@976|Bacteroidetes,47KG8@768503|Cytophagia	976|Bacteroidetes	H	MoeZ MoeB domain	moeZ	-	2.7.7.80,2.8.1.11	ko:K21029,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
k59_1634190_1	933262.AXAM01000004_gene2358	8.42e-48	160.0	COG2203@1|root,COG2203@2|Bacteria,1R6PX@1224|Proteobacteria,42NG9@68525|delta/epsilon subdivisions,2WKCE@28221|Deltaproteobacteria,2MING@213118|Desulfobacterales	28221|Deltaproteobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
k59_803793_1	1108045.GORHZ_118_00090	1.2e-32	119.0	COG1150@1|root,COG1150@2|Bacteria,2H2X3@201174|Actinobacteria	201174|Actinobacteria	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
k59_803793_2	1108045.GORHZ_118_00100	2.68e-59	185.0	COG2044@1|root,COG2044@2|Bacteria,2H50T@201174|Actinobacteria	201174|Actinobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE_2
k59_635726_1	298655.KI912266_gene1355	1e-37	154.0	COG1409@1|root,COG3291@1|root,COG1409@2|Bacteria,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4ETCD@85013|Frankiales	201174|Actinobacteria	S	Laminin G domain	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
k59_1694953_1	669262.COK_1283	2.81e-64	209.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1Y6UY@135625|Pasteurellales	135625|Pasteurellales	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_459428_1	1001530.BACE01000013_gene1770	1.08e-20	82.8	COG2975@1|root,COG2975@2|Bacteria,1N7C1@1224|Proteobacteria,1SC9F@1236|Gammaproteobacteria,1XYVQ@135623|Vibrionales	135623|Vibrionales	S	protein conserved in bacteria	iscX	-	-	-	-	-	-	-	-	-	-	-	Fe-S_assembly
k59_459428_3	1123401.JHYQ01000027_gene3140	5.21e-30	119.0	COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,463NJ@72273|Thiotrichales	72273|Thiotrichales	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB	hscA	-	-	-	-	-	-	-	-	-	-	-	HSP70
k59_517377_1	314254.OA2633_00655	4.96e-33	123.0	COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,2TRFI@28211|Alphaproteobacteria,43ZKK@69657|Hyphomonadaceae	28211|Alphaproteobacteria	Q	homogentisate 1,2-dioxygenase	hmgA	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
k59_517377_2	1288826.MSNKSG1_08498	1.06e-78	246.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,4653T@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed	fadI	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_635733_1	367299.JOEE01000003_gene2706	4.29e-117	361.0	COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4FF6A@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_343665_1	1123393.KB891316_gene1837	2.31e-82	259.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,2VICS@28216|Betaproteobacteria,1KSAQ@119069|Hydrogenophilales	119069|Hydrogenophilales	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
k59_1694968_1	1121921.KB898707_gene878	5.63e-61	205.0	COG0729@1|root,COG0729@2|Bacteria,1PFDU@1224|Proteobacteria,1RMUN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Outer membrane protein protective antigen OMA87	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
k59_1045401_1	1479238.JQMZ01000001_gene1097	1.86e-80	240.0	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,2U710@28211|Alphaproteobacteria,43XNF@69657|Hyphomonadaceae	28211|Alphaproteobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
k59_1459846_2	471853.Bcav_2352	1.19e-82	257.0	COG0472@1|root,COG0472@2|Bacteria,2HS8K@201174|Actinobacteria	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1459846_3	1123065.ATWL01000001_gene565	3.51e-05	47.4	2D1T0@1|root,32TBA@2|Bacteria,2I8E5@201174|Actinobacteria	201174|Actinobacteria	S	copper ion homeostasis	mctB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0008150,GO:0009279,GO:0015267,GO:0015288,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0044425,GO:0044462,GO:0044464,GO:0046930,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098796	-	-	-	-	-	-	-	-	-	-	MctB
k59_1751473_1	935866.JAER01000009_gene791	1.17e-28	114.0	COG2723@1|root,COG2723@2|Bacteria,2GJAF@201174|Actinobacteria,4DP9T@85009|Propionibacteriales	201174|Actinobacteria	G	Glycosyl hydrolase family 1	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
k59_1576111_2	1265505.ATUG01000002_gene2132	2.37e-32	125.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,42YBQ@68525|delta/epsilon subdivisions,2WTKK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_695571_1	1049564.TevJSym_bh00260	2.83e-77	231.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1J69H@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_5014	PRA-CH,PRA-PH
k59_695571_2	1249627.D779_0077	6.22e-13	64.3	COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,1S8R4@1236|Gammaproteobacteria,1WYHH@135613|Chromatiales	135613|Chromatiales	E	phosphoribosyl-ATP pyrophosphohydrolase	hisE	-	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
k59_1159250_1	1348657.M622_00490	7.02e-50	171.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,2KV1Y@206389|Rhodocyclales	206389|Rhodocyclales	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1159250_2	935863.AWZR01000003_gene2568	8.6e-59	193.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1X3IG@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA	-	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1045430_1	1234364.AMSF01000055_gene1093	2.71e-46	155.0	COG0625@1|root,COG0625@2|Bacteria,1MY47@1224|Proteobacteria,1RRI3@1236|Gammaproteobacteria,1X3MP@135614|Xanthomonadales	135614|Xanthomonadales	O	glutathione s-transferase	gst4	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_C_3,GST_N,GST_N_3
k59_1045430_2	1121004.ATVC01000007_gene1135	2.05e-22	95.1	COG3235@1|root,COG3235@2|Bacteria,1RDHR@1224|Proteobacteria,2VRKF@28216|Betaproteobacteria,2KRPU@206351|Neisseriales	206351|Neisseriales	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	CbiM
k59_1224743_1	1469245.JFBG01000020_gene1068	1.57e-28	112.0	COG2802@1|root,COG2802@2|Bacteria,1RFYH@1224|Proteobacteria	1224|Proteobacteria	S	Peptidase S16, lon domain protein	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
k59_1224743_2	326442.PSHAa2306	0.000135	43.1	2E6FY@1|root,33139@2|Bacteria,1N84P@1224|Proteobacteria,1SCVV@1236|Gammaproteobacteria,2Q3FV@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Putative prokaryotic signal transducing protein	BPP4288	-	-	-	-	-	-	-	-	-	-	-	DUF2007
k59_1751492_1	521719.ATXQ01000006_gene1351	6.86e-85	260.0	COG0167@1|root,COG0167@2|Bacteria,1MXER@1224|Proteobacteria,1RRTA@1236|Gammaproteobacteria,1YH9F@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	CF	Dihydroorotate dehydrogenase	-	-	1.3.1.1,1.3.98.1	ko:K00226,ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046,M00051	R00977,R01414,R01867,R11026	RC00051,RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4_21
k59_1399562_1	420662.Mpe_A2822	1.05e-17	80.5	COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,2VJ4W@28216|Betaproteobacteria,1KISY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Hydrogenase maturation protease	hoxM	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
k59_1399562_2	1122201.AUAZ01000010_gene2554	4.54e-92	278.0	COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,1RNTH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	b-type cytochrome subunit	hyaC	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0020037,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0071944,GO:0097159,GO:1901363,GO:1902494	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
k59_226185_1	546274.EIKCOROL_01800	1.92e-63	200.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,2VRGS@28216|Betaproteobacteria,2KR3W@206351|Neisseriales	206351|Neisseriales	S	Macro domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Macro
k59_1576144_2	1121405.dsmv_1836	4.78e-13	68.9	COG1181@1|root,COG1181@2|Bacteria,1MX3I@1224|Proteobacteria,42SA1@68525|delta/epsilon subdivisions,2WNIR@28221|Deltaproteobacteria,2MIAX@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
k59_755151_1	876044.IMCC3088_1442	4.14e-12	68.6	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1J4RK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_755151_2	395493.BegalDRAFT_0856	1.82e-99	307.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,45ZNE@72273|Thiotrichales	72273|Thiotrichales	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
k59_1806072_1	1046724.KB889862_gene1459	6.53e-48	166.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,464B7@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_1806072_2	765912.Thimo_2096	9.77e-19	82.8	COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,1WXGQ@135613|Chromatiales	135613|Chromatiales	S	High frequency lysogenization protein HflD homolog	hflD	-	-	ko:K07153	-	-	-	-	ko00000	-	-	-	DUF489
k59_803862_1	1267005.KB911265_gene3596	2.58e-73	247.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,3N6E3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the helicase family. UvrD subfamily	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1459893_1	713586.KB900536_gene1039	9.24e-40	146.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1WXJT@135613|Chromatiales	135613|Chromatiales	F	Belongs to the 5'-nucleotidase family	-	-	-	ko:K17224	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	5_nucleotid_C
k59_576732_1	1232410.KI421421_gene3769	2.21e-19	89.4	COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,42NTH@68525|delta/epsilon subdivisions,2WJ8N@28221|Deltaproteobacteria,43S96@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
k59_576732_2	177437.HRM2_00900	2e-18	84.3	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MIEI@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_695604_1	367299.JOEE01000003_gene2939	3.97e-58	186.0	COG1544@1|root,COG1544@2|Bacteria,2GMYF@201174|Actinobacteria,4FE8C@85021|Intrasporangiaceae	201174|Actinobacteria	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
k59_1224773_1	715226.ABI_02830	3.88e-25	104.0	COG1073@1|root,COG1073@2|Bacteria,1QUQB@1224|Proteobacteria,2UC51@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
k59_226205_1	870187.Thini_1187	1.84e-117	358.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,4608U@72273|Thiotrichales	72273|Thiotrichales	P	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
k59_803869_1	861299.J421_5755	4.36e-40	145.0	COG0076@1|root,COG0076@2|Bacteria,1ZSZN@142182|Gemmatimonadetes	2|Bacteria	E	Pyridoxal-dependent decarboxylase conserved domain	rhbB	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
k59_1226295_1	240015.ACP_0337	4.81e-50	175.0	COG3046@1|root,COG3046@2|Bacteria,3Y47V@57723|Acidobacteria,2JJ03@204432|Acidobacteriia	204432|Acidobacteriia	S	Deoxyribodipyrimidine photo-lyase-related protein	-	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP,FAD_binding_7
k59_1226295_2	494419.ALPM01000036_gene3185	4.48e-05	47.4	COG0842@1|root,COG0842@2|Bacteria,2GVC2@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
k59_179090_2	935839.JAGJ01000005_gene2607	1.47e-31	115.0	COG0607@1|root,COG0607@2|Bacteria,2IQIP@201174|Actinobacteria,4F52P@85017|Promicromonosporaceae	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_179090_3	1304865.JAGF01000001_gene657	5.59e-44	144.0	COG1937@1|root,COG1937@2|Bacteria,2IQ7U@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
k59_824535_1	1348657.M622_13655	3.55e-76	239.0	COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,2VJ1V@28216|Betaproteobacteria,2KVJ5@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S dicluster domain	-	-	-	ko:K17048,ko:K17051	ko00642,ko01100,ko01120,ko01220,map00642,map01100,map01120,map01220	-	R05745	RC00275	ko00000,ko00001,ko02000	5.A.3.8,5.A.3.9	-	-	Fer4_11
k59_413754_1	292415.Tbd_1833	5.19e-39	135.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2VK46@28216|Betaproteobacteria,1KRMG@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Rieske [2Fe-2S] domain	-	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
k59_413754_2	595537.Varpa_1280	4.82e-52	177.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,4AAVH@80864|Comamonadaceae	28216|Betaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
k59_765813_1	1380354.JIAN01000008_gene3517	8.92e-33	127.0	COG2822@1|root,COG2822@2|Bacteria,2GJPY@201174|Actinobacteria	201174|Actinobacteria	P	periplasmic lipoprotein involved in iron transport	efeO	-	-	ko:K07224	-	-	-	-	ko00000,ko02000	2.A.108.2.3	-	-	Cupredoxin_1,Peptidase_M75
k59_1118094_1	1408473.JHXO01000007_gene810	3.88e-110	332.0	COG0673@1|root,COG0673@2|Bacteria,4NF4Q@976|Bacteroidetes,2FQ86@200643|Bacteroidia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_1060007_1	998088.B565_3191	1.82e-17	80.1	COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,1SD3P@1236|Gammaproteobacteria,1Y4K5@135624|Aeromonadales	135624|Aeromonadales	U	Preprotein translocase	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
k59_1060007_2	1123401.JHYQ01000005_gene292	5.53e-107	315.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,4608G@72273|Thiotrichales	72273|Thiotrichales	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
k59_1235834_2	1255043.TVNIR_1306	3.26e-91	287.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	ybbN	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_1705434_1	1168065.DOK_16183	5.6e-17	79.7	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,1J4S7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispA	GO:0003674,GO:0003824,GO:0004161,GO:0004337,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033383,GO:0033384,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045337,GO:0045338,GO:0071704,GO:0090407,GO:1901576	2.5.1.1,2.5.1.10,2.5.1.29	ko:K00795,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iPC815.YPO3176,iSFV_1184.SFV_0386	polyprenyl_synt
k59_1705434_2	765914.ThisiDRAFT_1270	3.28e-17	79.3	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,1RNDY@1236|Gammaproteobacteria,1WW3H@135613|Chromatiales	135613|Chromatiales	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
k59_824544_1	1123400.KB904758_gene2211	2.17e-24	102.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,460WQ@72273|Thiotrichales	72273|Thiotrichales	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
k59_885217_1	864073.HFRIS_014969	1.57e-61	199.0	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2VHGS@28216|Betaproteobacteria,4726F@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex	ccoP	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
k59_1000704_1	1234364.AMSF01000036_gene243	2e-92	291.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,1SZS1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EU	PFAM peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_4025_1	1217708.F887_03370	3.52e-15	76.3	28IZ5@1|root,2Z8WP@2|Bacteria,1R6WI@1224|Proteobacteria,1S87I@1236|Gammaproteobacteria,3NM14@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1763942_1	870187.Thini_1240	3.56e-101	306.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,1RQGG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Seven times multi-haem cytochrome CxxCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Multi-haem_cyto
k59_1763944_1	323261.Noc_1662	5.22e-08	54.7	COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,1WXUQ@135613|Chromatiales	135613|Chromatiales	EH	PFAM Aminotransferase, class IV	-	-	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	-	Aminotran_4
k59_4029_1	880073.Calab_3506	8.62e-88	269.0	COG0379@1|root,COG0379@2|Bacteria,2NP47@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0030312,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b0750,iAPECO1_1312.APECO1_1338,iB21_1397.B21_00692,iBWG_1329.BWG_0602,iECBD_1354.ECBD_2917,iECB_1328.ECB_00703,iECDH10B_1368.ECDH10B_0817,iECDH1ME8569_1439.ECDH1ME8569_0703,iECD_1391.ECD_00703,iECED1_1282.ECED1_0711,iECOK1_1307.ECOK1_0750,iECP_1309.ECP_0761,iECS88_1305.ECS88_0766,iECSP_1301.ECSP_0802,iECs_1301.ECs0778,iETEC_1333.ETEC_0754,iEcDH1_1363.EcDH1_2892,iEcolC_1368.EcolC_2912,iHN637.CLJU_RS12020,iJN746.PP_1231,iJO1366.b0750,iJR904.b0750,iUMN146_1321.UM146_13905,iUTI89_1310.UTI89_C0747,iY75_1357.Y75_RS03905,iZ_1308.Z0919	NadA
k59_1411919_2	589865.DaAHT2_1625	6.73e-08	55.8	COG1639@1|root,COG1639@2|Bacteria,1MXVB@1224|Proteobacteria	1224|Proteobacteria	T	Signal transduction protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
k59_1177149_1	435908.IDSA_01430	3.05e-83	263.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,2QG08@267893|Idiomarinaceae	1236|Gammaproteobacteria	U	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
k59_1000708_1	998088.B565_3399	5.31e-45	160.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1Y3NG@135624|Aeromonadales	135624|Aeromonadales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
k59_648753_1	1249627.D779_0203	1.76e-129	387.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1WW1V@135613|Chromatiales	135613|Chromatiales	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
k59_1296202_1	497964.CfE428DRAFT_1577	6.15e-120	353.0	COG0502@1|root,COG0502@2|Bacteria,46SFX@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Biotin and Thiamin Synthesis associated domain	-	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
k59_413777_1	2340.JV46_14610	9.45e-166	476.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,1RMQC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_1763950_1	396588.Tgr7_0696	8.61e-62	207.0	COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1WWFZ@135613|Chromatiales	135613|Chromatiales	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase
k59_120491_1	1454010.JEOE01000049_gene2703	5.65e-62	206.0	COG0508@1|root,COG0508@2|Bacteria,2GM0D@201174|Actinobacteria,4F0G9@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM catalytic domain-containing protein of components of various dehydrogenase complexes	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1297128_1	367299.JOEE01000007_gene140	4.74e-119	357.0	COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria,4FEZD@85021|Intrasporangiaceae	201174|Actinobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iNJ661.Rv3436c	GATase_6,SIS
k59_1001213_1	33876.JNXY01000001_gene5873	3.9e-88	266.0	COG0702@1|root,COG0702@2|Bacteria,2GKNN@201174|Actinobacteria,4DETW@85008|Micromonosporales	201174|Actinobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
k59_944902_1	870187.Thini_2393	3.92e-51	170.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,4604S@72273|Thiotrichales	72273|Thiotrichales	J	glycyl-tRNA synthetase, alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
k59_944902_2	1523503.JPMY01000046_gene1178	7.85e-14	72.4	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378	DALR_1,tRNA_synt_2f
k59_590791_2	713586.KB900536_gene989	6.14e-42	142.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria,1WYDP@135613|Chromatiales	135613|Chromatiales	K	Ribosomal-protein-alanine acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
k59_590794_1	420662.Mpe_A3759	6.3e-84	257.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2VHNY@28216|Betaproteobacteria,1KJYP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
k59_357773_2	396588.Tgr7_2627	2.93e-63	199.0	COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,1RNSJ@1236|Gammaproteobacteria,1WY08@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4_21
k59_1177675_1	1366050.N234_00150	1.49e-88	291.0	COG4913@1|root,COG4913@2|Bacteria,1N16Z@1224|Proteobacteria,2VJD2@28216|Betaproteobacteria,1K66J@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SbcCD_C
k59_944921_1	1049564.TevJSym_ak00640	4.89e-76	248.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1J4R4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_1297155_2	1121403.AUCV01000012_gene4033	3.92e-52	167.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,43DA7@68525|delta/epsilon subdivisions,2X8GU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_708153_1	1535422.ND16A_1814	2.42e-41	155.0	COG2132@1|root,COG2132@2|Bacteria,1PM6Q@1224|Proteobacteria,1RRZJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_3
k59_1825247_1	243090.RB1477	1.18e-09	60.1	COG3119@1|root,COG3119@2|Bacteria,2IX0S@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_886112_1	686340.Metal_2124	2.46e-170	499.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria,1XEH4@135618|Methylococcales	135618|Methylococcales	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_357784_1	768671.ThimaDRAFT_0602	1.71e-221	652.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW08@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_825189_1	1158292.JPOE01000002_gene3054	1.06e-46	158.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,2VIQF@28216|Betaproteobacteria,1KIY3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
k59_825189_2	981336.F944_00789	3.88e-08	53.9	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,3NK1I@468|Moraxellaceae	1236|Gammaproteobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	iPC815.YPO3376	Enolase_C,Enolase_N
k59_886113_1	631454.N177_0392	4.94e-76	250.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,1JPV7@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Heavy-metal-associated domain	actP	-	3.6.3.54	ko:K17686,ko:K19597	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5,3.A.3.5.20	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_1825255_1	864051.BurJ1DRAFT_0974	7.54e-82	269.0	28HKI@1|root,2Z7VC@2|Bacteria,1MW0I@1224|Proteobacteria,2VPEJ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_414343_2	290340.AAur_3609	1.44e-46	162.0	COG3497@1|root,COG3497@2|Bacteria,2GMJA@201174|Actinobacteria,1W9VA@1268|Micrococcaceae	201174|Actinobacteria	S	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
k59_649400_1	265072.Mfla_0735	7.47e-101	308.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2VH8D@28216|Betaproteobacteria,2KM4Y@206350|Nitrosomonadales	206350|Nitrosomonadales	S	PFAM peptidase M16 domain protein	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_590818_2	279714.FuraDRAFT_2817	6.01e-67	209.0	COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,2VRSR@28216|Betaproteobacteria,2KRAY@206351|Neisseriales	206351|Neisseriales	S	Predicted membrane protein (DUF2238)	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
k59_708172_1	314285.KT71_10909	5.49e-11	63.2	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1J9D2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Dimerisation domain of Zinc Transporter	fieF	GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005385,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006829,GO:0006873,GO:0006875,GO:0006876,GO:0006882,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015086,GO:0015093,GO:0015291,GO:0015318,GO:0015341,GO:0015562,GO:0015684,GO:0015691,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0030003,GO:0034220,GO:0034755,GO:0042592,GO:0042802,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055069,GO:0055073,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070574,GO:0070838,GO:0071577,GO:0071944,GO:0072503,GO:0072507,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:1903874	-	ko:K13283	-	-	-	-	ko00000,ko02000	2.A.4.7.1	-	-	Cation_efflux,ZT_dimer
k59_886139_2	1232437.KL662048_gene5095	2.4e-33	117.0	COG0599@1|root,COG0599@2|Bacteria,1NBJR@1224|Proteobacteria,42SYS@68525|delta/epsilon subdivisions,2WPQD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
k59_4885_2	1123399.AQVE01000003_gene2194	6.25e-07	50.8	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,45ZTE@72273|Thiotrichales	72273|Thiotrichales	M	Catalyzes cross-linking of the peptidoglycan cell wall at the division septum	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
k59_1118618_1	556268.OFAG_01888	2.29e-78	236.0	COG1112@1|root,COG1112@2|Bacteria	2|Bacteria	L	Superfamily I DNA and RNA helicases and helicase subunits	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,AAA_30,PDDEXK_1
k59_1118618_2	1198232.CYCME_0984	0.0	996.0	COG1401@1|root,COG2256@1|root,COG1401@2|Bacteria,COG2256@2|Bacteria,1MYQM@1224|Proteobacteria,1RSU7@1236|Gammaproteobacteria,46138@72273|Thiotrichales	72273|Thiotrichales	V	AAA domain (dynein-related subfamily)	-	-	-	ko:K07452	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	AAA_5
k59_1118618_3	228410.NE2529	1.9e-56	189.0	COG4268@1|root,COG4268@2|Bacteria,1R1FP@1224|Proteobacteria,2VQZ7@28216|Betaproteobacteria	28216|Betaproteobacteria	V	McrBC 5-methylcytosine restriction system component	mcrC	-	-	ko:K19147	-	-	-	-	ko00000,ko02048	-	-	-	McrBC
k59_1588328_1	1304865.JAGF01000001_gene3708	3.11e-71	226.0	COG0707@1|root,COG0707@2|Bacteria,2GJEM@201174|Actinobacteria,4F0QD@85016|Cellulomonadaceae	201174|Actinobacteria	M	Glycosyltransferase family 28 N-terminal domain	murG	-	2.4.1.227,6.3.2.8	ko:K01924,ko:K02563	ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112	-	R03193,R05032,R05662	RC00005,RC00049,RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_590836_1	666681.M301_2514	2.32e-41	155.0	COG3850@1|root,COG5001@1|root,COG3850@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria,2KKWK@206350|Nitrosomonadales	206350|Nitrosomonadales	T	TIGRFAM diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2222,EAL,GGDEF,HAMP
k59_532054_1	543728.Vapar_0665	1.26e-84	266.0	COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,2VKSJ@28216|Betaproteobacteria,4ACTJ@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM transposase IS66	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_1706111_1	335543.Sfum_1550	1.78e-74	250.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2MR5Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_121139_1	1095767.CAHD01000122_gene2467	6.45e-72	227.0	COG0345@1|root,COG0345@2|Bacteria,2GJ7D@201174|Actinobacteria,4F0WU@85016|Cellulomonadaceae	201174|Actinobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
k59_64326_1	1049564.TevJSym_ac01950	6.93e-85	261.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1J4M5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_4904_1	396588.Tgr7_1535	8.22e-79	258.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1WXK8@135613|Chromatiales	135613|Chromatiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_708188_1	1122179.KB890480_gene3169	4.32e-33	128.0	COG3119@1|root,COG3119@2|Bacteria,4NFGI@976|Bacteroidetes,1IQA2@117747|Sphingobacteriia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
k59_1529759_1	525257.HMPREF0204_14737	2.11e-33	129.0	COG0837@1|root,COG0837@2|Bacteria,4NGYX@976|Bacteroidetes,1I0I6@117743|Flavobacteriia,3ZPRZ@59732|Chryseobacterium	976|Bacteroidetes	G	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
k59_1412597_1	717785.HYPMC_4393	1.91e-121	352.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TTC8@28211|Alphaproteobacteria,3N9GC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	mtkB	-	6.2.1.5,6.2.1.9	ko:K01902,ko:K08692	ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00346,M00374,M00620	R00405,R01256,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_649433_2	1121937.AUHJ01000019_gene1347	4.46e-11	60.5	COG2841@1|root,COG2841@2|Bacteria,1N760@1224|Proteobacteria,1SCCY@1236|Gammaproteobacteria,4698E@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF465)	-	-	-	ko:K09794	-	-	-	-	ko00000	-	-	-	DUF465
k59_649433_3	1112212.JH584235_gene1570	4.97e-24	97.4	COG0235@1|root,COG0235@2|Bacteria,1RE8T@1224|Proteobacteria,2U93H@28211|Alphaproteobacteria,2K2VG@204457|Sphingomonadales	204457|Sphingomonadales	G	Class II Aldolase and Adducin N-terminal domain	mtnB	-	4.2.1.109	ko:K08964	ko00270,ko01100,map00270,map01100	M00034	R07392	RC01939	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
k59_1588345_1	926569.ANT_00390	1.4e-25	110.0	COG1070@1|root,COG1070@2|Bacteria,2G6JV@200795|Chloroflexi	200795|Chloroflexi	G	Carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	MutL
k59_1353843_1	765912.Thimo_0459	5.74e-38	138.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1WVZP@135613|Chromatiales	135613|Chromatiales	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_590860_1	1192124.LIG30_0298	4.89e-40	145.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VHST@28216|Betaproteobacteria,1K00F@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.113	ko:K12256	ko00330,ko01100,map00330,map01100	-	R08714	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_590860_2	438753.AZC_4442	2.34e-95	293.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TRCP@28211|Alphaproteobacteria,3EYIZ@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Glutamine synthetase, catalytic domain	glnA1	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_649443_1	593907.Celgi_0338	3.37e-106	329.0	COG0370@1|root,COG0370@2|Bacteria,2GTV2@201174|Actinobacteria	201174|Actinobacteria	P	Ferrous iron transport protein B	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoA,FeoB_C,FeoB_N,Gate
k59_64368_1	935839.JAGJ01000015_gene2111	3.02e-67	219.0	COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria,4F3EU@85017|Promicromonosporaceae	201174|Actinobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
k59_238906_1	177439.DP1125	1.22e-44	150.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,42MPW@68525|delta/epsilon subdivisions,2WN96@28221|Deltaproteobacteria,2MJHZ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_238906_2	883.DvMF_0079	1.57e-05	46.2	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,42NV2@68525|delta/epsilon subdivisions,2WNJ1@28221|Deltaproteobacteria,2M9CC@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_1060730_1	367299.JOEE01000001_gene2026	1.16e-61	194.0	COG0406@1|root,COG0406@2|Bacteria,2GMXF@201174|Actinobacteria,4FG3C@85021|Intrasporangiaceae	201174|Actinobacteria	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_1060730_2	367299.JOEE01000001_gene2027	2.46e-66	207.0	COG0526@1|root,COG0526@2|Bacteria,2GP7J@201174|Actinobacteria,4FG0N@85021|Intrasporangiaceae	201174|Actinobacteria	CO	Thiol disulfide interchange protein	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
k59_121164_1	526222.Desal_2943	4.05e-18	85.1	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42MSJ@68525|delta/epsilon subdivisions,2WKHJ@28221|Deltaproteobacteria,2M8TU@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_590873_1	765911.Thivi_2850	6.63e-60	197.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1WWHU@135613|Chromatiales	135613|Chromatiales	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_126573_2	1198232.CYCME_1545	0.000163	42.4	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,461GC@72273|Thiotrichales	72273|Thiotrichales	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
k59_248368_1	1502851.FG93_05567	1.62e-41	155.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria,3JSG2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	PAS fold	pleC	-	2.7.13.3	ko:K07716	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_7
k59_1534874_2	1268237.G114_11180	8.42e-18	84.7	COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,1Y40J@135624|Aeromonadales	135624|Aeromonadales	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009274,GO:0009276,GO:0009987,GO:0030312,GO:0030313,GO:0031975,GO:0044464,GO:0051301,GO:0071944	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	-
k59_1183304_1	335543.Sfum_1863	1.97e-68	213.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,42P56@68525|delta/epsilon subdivisions,2WK5J@28221|Deltaproteobacteria,2MQ5V@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_893450_1	1120941.AUBL01000077_gene1498	2.15e-15	75.1	COG0491@1|root,COG0491@2|Bacteria,2GJU0@201174|Actinobacteria,4D4N8@85005|Actinomycetales	201174|Actinobacteria	S	Metallo-beta-lactamase domain protein	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
k59_185282_1	1049564.TevJSym_ad00300	5.04e-104	316.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1J90E@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_185282_2	1049564.TevJSym_ad00290	2.73e-50	180.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,1J980@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2309)	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k59_1304665_1	880073.Calab_1086	1.67e-67	218.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,2NQE8@2323|unclassified Bacteria	2|Bacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	GAF,GAF_2,HD,HD_5
k59_537295_1	1117318.PRUB_07255	1.3e-125	379.0	COG3961@1|root,COG3961@2|Bacteria,1MW2F@1224|Proteobacteria,1RQFY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GH	Belongs to the TPP enzyme family	ipdC	-	4.1.1.1,4.1.1.74	ko:K01568,ko:K04103	ko00010,ko00380,ko01100,ko01110,ko01130,map00010,map00380,map01100,map01110,map01130	-	R00014,R00755,R01974	RC00027,RC00375,RC00506,RC02744	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_248382_1	555088.DealDRAFT_2218	2.7e-05	51.6	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,42JYE@68298|Syntrophomonadaceae	186801|Clostridia	O	PFAM peptidase S1 and S6 chymotrypsin Hap	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_302369_1	331869.BAL199_29280	1.25e-114	345.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2TRTQ@28211|Alphaproteobacteria,4BPG5@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_1653108_1	862515.HMPREF0658_1803	3.01e-24	103.0	COG2244@1|root,COG2244@2|Bacteria,4NDZ0@976|Bacteroidetes,2FKYU@200643|Bacteroidia	976|Bacteroidetes	S	Polysaccharide biosynthesis protein	cap	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
k59_1653108_2	313606.M23134_01669	2.96e-36	134.0	COG1560@1|root,COG1560@2|Bacteria,4NGQU@976|Bacteroidetes,47MHM@768503|Cytophagia	976|Bacteroidetes	M	Lipid A biosynthesis acyltransferase	waaM	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_770666_1	367299.JOEE01000003_gene2889	7.23e-125	369.0	COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria,4FEA3@85021|Intrasporangiaceae	201174|Actinobacteria	C	Malate dehydrogenase	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
k59_478475_1	1192034.CAP_8946	6.46e-44	152.0	COG0598@1|root,COG0598@2|Bacteria,1N04R@1224|Proteobacteria	1224|Proteobacteria	P	Magnesium transport protein CorA	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1832822_2	713586.KB900536_gene2211	6.56e-97	295.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,1WWBP@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K07814,ko:K13815	ko02020,ko02024,map02020,map02024	M00517	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HD,Response_reg
k59_770669_2	56780.SYN_00579	5.08e-25	105.0	COG2509@1|root,COG2509@2|Bacteria,1MV6P@1224|Proteobacteria,42MT3@68525|delta/epsilon subdivisions,2WIK5@28221|Deltaproteobacteria,2MR8Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	FAD dependent oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,FAD_binding_3,HI0933_like,Pyr_redox_2
k59_1534884_1	941639.BCO26_2713	1.26e-146	436.0	COG3039@1|root,COG3039@2|Bacteria,1TRUS@1239|Firmicutes,4HCCQ@91061|Bacilli,1ZHBM@1386|Bacillus	91061|Bacilli	L	Transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2,DUF772
k59_71777_1	1278073.MYSTI_00856	7.05e-26	112.0	COG0810@1|root,COG1629@1|root,COG0810@2|Bacteria,COG4771@2|Bacteria,1R5B9@1224|Proteobacteria,43C1I@68525|delta/epsilon subdivisions,2X7C6@28221|Deltaproteobacteria,2YWPC@29|Myxococcales	28221|Deltaproteobacteria	MP	Periplasmic protein TonB links inner and outer membranes	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_C,TonB_dep_Rec
k59_1832829_1	1380393.JHVP01000030_gene4845	3.32e-131	380.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4ERIG@85013|Frankiales	201174|Actinobacteria	L	PFAM Transposase, Mutator	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_1183330_1	765911.Thivi_3390	5.73e-45	154.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,1S612@1236|Gammaproteobacteria,1WYDB@135613|Chromatiales	135613|Chromatiales	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
k59_893488_1	1172188.KB911825_gene3551	5.1e-36	135.0	COG0438@1|root,COG0438@2|Bacteria,2ICB6@201174|Actinobacteria,4FG9I@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_770676_1	1177179.A11A3_06390	8.9e-11	62.8	COG2199@1|root,COG3706@2|Bacteria,1R59V@1224|Proteobacteria,1S4YK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
k59_1068053_1	935839.JAGJ01000013_gene2873	4.18e-181	521.0	COG1112@1|root,COG1112@2|Bacteria,2H3MV@201174|Actinobacteria	201174|Actinobacteria	L	Type III restriction enzyme res subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,NERD,UvrD_C_2
k59_248420_1	1125700.HMPREF9195_00389	4.58e-21	92.0	COG0766@1|root,COG0766@2|Bacteria,2J5JB@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_248420_2	926550.CLDAP_25100	2.07e-80	243.0	COG0221@1|root,COG0221@2|Bacteria,2G6T4@200795|Chloroflexi	200795|Chloroflexi	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
k59_952499_1	1415779.JOMH01000001_gene3039	9.65e-55	178.0	COG3707@1|root,COG3707@2|Bacteria,1MXDV@1224|Proteobacteria,1S3YY@1236|Gammaproteobacteria,1X6AA@135614|Xanthomonadales	135614|Xanthomonadales	T	ANTAR	nasT	-	-	ko:K07183	-	-	-	-	ko00000,ko02022	-	-	-	ANTAR,Response_reg
k59_1653133_1	765911.Thivi_0917	3.08e-106	317.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1WW9F@135613|Chromatiales	135613|Chromatiales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1534895_2	301.JNHE01000003_gene1980	5.24e-52	181.0	COG0845@1|root,COG0845@2|Bacteria,1QTZQ@1224|Proteobacteria,1T1J7@1236|Gammaproteobacteria,1YEQY@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_952500_1	713586.KB900536_gene2613	4.7e-124	377.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales	135613|Chromatiales	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_126625_1	365528.KB891178_gene4767	2.92e-36	136.0	COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria,4EWGM@85013|Frankiales	201174|Actinobacteria	L	required for the transposition of insertion element IS2404	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_1832853_1	414684.RC1_0801	5.18e-32	117.0	COG0811@1|root,COG0811@2|Bacteria,1MX60@1224|Proteobacteria,2UAB1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	TonB system transport protein ExbB	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_1832853_2	1283300.ATXB01000001_gene2136	1.01e-45	151.0	COG0848@1|root,COG0848@2|Bacteria,1RI4M@1224|Proteobacteria,1S4GX@1236|Gammaproteobacteria,1XGM2@135618|Methylococcales	135618|Methylococcales	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_1418355_1	1343740.M271_19825	2.01e-58	191.0	COG0619@1|root,COG0619@2|Bacteria,2GKQ7@201174|Actinobacteria	201174|Actinobacteria	P	Cobalt ABC transporter	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
k59_893511_1	1304885.AUEY01000010_gene1690	5.58e-60	207.0	COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,2MHP4@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_248450_1	593907.Celgi_0600	2.92e-72	234.0	COG2148@1|root,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria	201174|Actinobacteria	M	sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
k59_302400_1	493475.GARC_2329	1.09e-163	499.0	28HKI@1|root,2Z7VC@2|Bacteria,1MW0I@1224|Proteobacteria,1RQ5H@1236|Gammaproteobacteria,469C8@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_830758_1	765911.Thivi_3470	3.13e-136	398.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1WWT4@135613|Chromatiales	135613|Chromatiales	U	Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_537341_1	330214.NIDE1291	4.35e-45	167.0	COG0210@1|root,COG0210@2|Bacteria,3J0VX@40117|Nitrospirae	40117|Nitrospirae	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_248459_1	1123393.KB891316_gene1497	1.09e-84	259.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VH51@28216|Betaproteobacteria,1KRIP@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Peptidase family U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
k59_419671_1	522306.CAP2UW1_1761	1.02e-75	234.0	COG5587@1|root,COG5587@2|Bacteria,1R8B4@1224|Proteobacteria,2WG8I@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Conserved hypothetical protein (DUF2461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
k59_419671_2	765912.Thimo_1294	8.55e-41	148.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,1WW58@135613|Chromatiales	135613|Chromatiales	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_185338_1	1168034.FH5T_20550	1.05e-43	155.0	COG2223@1|root,COG2223@2|Bacteria,4NHX9@976|Bacteroidetes,2FZ04@200643|Bacteroidia	976|Bacteroidetes	P	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
k59_830764_1	2340.JV46_10610	1.39e-61	194.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,1SASJ@1236|Gammaproteobacteria,1JBWJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Smr domain	-	-	-	-	-	-	-	-	-	-	-	-	Smr
k59_248463_1	1286106.MPL1_06502	7.72e-128	370.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,45ZN2@72273|Thiotrichales	72273|Thiotrichales	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_1304758_1	1168065.DOK_16958	8.87e-46	158.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,1J5Z0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Response regulator of the LytR AlgR family	algR	-	-	ko:K08083	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
k59_537358_1	367299.JOEE01000007_gene73	5.14e-129	372.0	COG3285@1|root,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4FEZ7@85021|Intrasporangiaceae	201174|Actinobacteria	L	ATP-dependent DNA ligase	ligD	-	-	-	-	-	-	-	-	-	-	-	DNA_primase_S
k59_248487_1	177437.HRM2_25410	3e-68	222.0	COG3385@1|root,COG5659@1|root,COG3385@2|Bacteria,COG5659@2|Bacteria,1R97Q@1224|Proteobacteria,42UH7@68525|delta/epsilon subdivisions,2X6SD@28221|Deltaproteobacteria,2MPID@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_365333_1	1268303.RHODMAR_0403	8.44e-45	156.0	2DBHY@1|root,2Z9DM@2|Bacteria,2GM2H@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1005671_1	443598.AUFA01000003_gene2405	3.63e-38	134.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VEU2@28211|Alphaproteobacteria,3JV0I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Evidence Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran
k59_1005671_2	991905.SL003B_1030	2.02e-106	332.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2TTJZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1711006_1	469595.CSAG_00401	5.09e-26	112.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,1RMVE@1236|Gammaproteobacteria,3WZFE@544|Citrobacter	1236|Gammaproteobacteria	C	TAT (twin-arginine translocation) pathway signal sequence	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_831537_3	1313172.YM304_27340	8.56e-14	71.6	COG3848@1|root,COG3848@2|Bacteria,2H2J1@201174|Actinobacteria	201174|Actinobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
k59_714407_1	177437.HRM2_30730	8.54e-30	122.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MI52@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
k59_831546_1	631362.Thi970DRAFT_03961	1.51e-71	225.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1WWNM@135613|Chromatiales	135613|Chromatiales	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_1479710_1	1163409.UUA_17005	1.19e-18	88.2	COG2234@1|root,COG2234@2|Bacteria,1MWQ0@1224|Proteobacteria,1S1UU@1236|Gammaproteobacteria,1X439@135614|Xanthomonadales	135614|Xanthomonadales	S	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
k59_538070_1	1232683.ADIMK_4155	3.19e-18	89.7	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,1RMMF@1236|Gammaproteobacteria,4652R@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	ytfN	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0097347	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
k59_72887_1	572477.Alvin_2411	3.79e-77	238.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1WWMV@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_249877_1	1231185.BAMP01000013_gene1901	2.56e-05	44.3	2AA5M@1|root,30ZEM@2|Bacteria,1PMCU@1224|Proteobacteria,2UZZS@28211|Alphaproteobacteria,43QQS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_249877_2	1454004.AW11_03458	1.33e-60	194.0	COG1028@1|root,COG1028@2|Bacteria,1MW4W@1224|Proteobacteria,2VNXP@28216|Betaproteobacteria,1KR0P@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1419181_1	1033802.SSPSH_002686	7.37e-78	251.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0471 Di- and tricarboxylate transporters	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_1305819_1	768671.ThimaDRAFT_2043	1.74e-31	123.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1WWE3@135613|Chromatiales	135613|Chromatiales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1305819_2	1049564.TevJSym_ab01840	8.85e-45	149.0	COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,1S94K@1236|Gammaproteobacteria,1J6Y3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2927 DNA polymerase III, chi subunit	holC	GO:0005575,GO:0005622,GO:0005623,GO:0006275,GO:0008150,GO:0009314,GO:0009360,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010556,GO:0010557,GO:0010604,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032298,GO:0032991,GO:0042575,GO:0043846,GO:0043847,GO:0044424,GO:0044464,GO:0045740,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051173,GO:0060255,GO:0061695,GO:0065007,GO:0080090,GO:0090329,GO:1902494,GO:1990234,GO:2000105,GO:2000112	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
k59_16293_1	1122194.AUHU01000013_gene710	3.52e-59	194.0	COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,464DJ@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Succinylglutamate desuccinylase aspartoacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
k59_16293_2	472759.Nhal_1063	1.54e-142	408.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,1WX7Z@135613|Chromatiales	135613|Chromatiales	HJ	Belongs to the RimK family	rimK	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
k59_72895_2	1415779.JOMH01000001_gene179	1.03e-98	296.0	COG0811@1|root,COG0811@2|Bacteria,1NXZ9@1224|Proteobacteria,1S154@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Pfam MotA TolQ ExbB proton channel family	-	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
k59_1535591_2	177437.HRM2_44710	1.77e-154	451.0	COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria	1224|Proteobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1479732_1	479434.Sthe_0823	3.01e-64	205.0	COG1024@1|root,COG1024@2|Bacteria,2G5JW@200795|Chloroflexi,27XKS@189775|Thermomicrobia	189775|Thermomicrobia	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
k59_1069151_1	768671.ThimaDRAFT_2060	9.16e-66	212.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,1RVNC@1236|Gammaproteobacteria,1WWMK@135613|Chromatiales	135613|Chromatiales	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_1479740_1	888060.HMPREF9081_2151	2.04e-29	124.0	COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,4H315@909932|Negativicutes	909932|Negativicutes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_894650_1	1288494.EBAPG3_29480	2.43e-47	160.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,2VHA6@28216|Betaproteobacteria,372EX@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_894650_2	42256.RradSPS_0231	1.32e-12	65.5	COG1898@1|root,COG1898@2|Bacteria,2GMW4@201174|Actinobacteria,4CQ10@84995|Rubrobacteria	84995|Rubrobacteria	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
k59_483816_2	471853.Bcav_2002	3.91e-77	241.0	COG0652@1|root,COG0652@2|Bacteria,2GN8G@201174|Actinobacteria	201174|Actinobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
k59_1423943_1	765912.Thimo_2447	4.98e-153	437.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1WWPK@135613|Chromatiales	135613|Chromatiales	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_190854_1	582899.Hden_3402	7.46e-37	132.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2TR11@28211|Alphaproteobacteria,3N6IQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_190854_2	648757.Rvan_3264	8.82e-85	265.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2TQYK@28211|Alphaproteobacteria,3N65Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_600889_1	314287.GB2207_03000	9.33e-25	109.0	COG2834@1|root,COG3391@1|root,COG3637@1|root,COG2834@2|Bacteria,COG3391@2|Bacteria,COG3637@2|Bacteria,1QWRQ@1224|Proteobacteria	1224|Proteobacteria	M	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Abhydrolase_3,Cadherin-like,Cadherin_3,TIG,VCBS
k59_1423946_1	1219375.CM002139_gene3176	1.55e-77	245.0	COG3844@1|root,COG3844@2|Bacteria,1MUKN@1224|Proteobacteria,1RPY3@1236|Gammaproteobacteria,1X3FQ@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016822,GO:0016823,GO:0019439,GO:0019441,GO:0019752,GO:0030429,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
k59_775567_2	1432055.GLUCORHAEAF1_03895	6.38e-16	77.8	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2TT2F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	NADH flavin oxidoreductase NADH oxidase	nemA	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_719663_1	1120970.AUBZ01000004_gene301	4.4e-35	130.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,465Y3@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0739 Membrane proteins related to metalloendopeptidases	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1716784_1	933262.AXAM01000001_gene339	8.5e-124	364.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2WJT6@28221|Deltaproteobacteria,2MHUV@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1364888_2	439235.Dalk_1134	3.77e-73	234.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,43BQX@68525|delta/epsilon subdivisions,2X71W@28221|Deltaproteobacteria,2MIFV@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
k59_719671_1	765912.Thimo_1931	6.12e-102	324.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_257722_1	1335757.SPICUR_06045	2.46e-34	122.0	COG4517@1|root,COG4517@2|Bacteria,1MZJX@1224|Proteobacteria,1S95D@1236|Gammaproteobacteria,1WZ3B@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF1820)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1820
k59_1659344_1	525904.Tter_1043	5.11e-12	70.5	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	peaD	-	-	-	-	-	-	-	-	-	-	-	Lactonase,Rhomboid
k59_1486758_1	926569.ANT_28310	3.55e-97	296.0	COG0167@1|root,COG0167@2|Bacteria,2G5T6@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_132774_1	1713.JOFV01000001_gene1992	1.29e-77	247.0	COG3387@1|root,COG3387@2|Bacteria,2ICV9@201174|Actinobacteria,4F0TM@85016|Cellulomonadaceae	201174|Actinobacteria	G	PFAM glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1716796_1	1144325.PMI22_00608	3.22e-83	261.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1S3FP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_484392_1	1279019.ARQK01000043_gene2131	1.08e-190	552.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1WWE3@135613|Chromatiales	135613|Chromatiales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1128220_1	189753.AXAS01000003_gene4825	5.93e-14	77.0	COG2807@1|root,COG2807@2|Bacteria,1QW6Q@1224|Proteobacteria,2TWQ5@28211|Alphaproteobacteria,3JZ82@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_308255_1	1313172.YM304_08170	2.15e-14	67.4	COG0051@1|root,COG0051@2|Bacteria,2IHRA@201174|Actinobacteria,4CN6W@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
k59_308255_2	1313172.YM304_08160	1.19e-76	238.0	COG0050@1|root,COG0050@2|Bacteria,2GK4T@201174|Actinobacteria,4CMSE@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_1077507_1	1158292.JPOE01000002_gene3441	1.38e-96	290.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VICP@28216|Betaproteobacteria,1KM74@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_775584_1	926560.KE387026_gene4174	5.13e-68	217.0	COG1131@1|root,COG1131@2|Bacteria,1WI6M@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_191445_1	880072.Desac_1417	1.15e-08	55.8	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,42N4U@68525|delta/epsilon subdivisions,2WJR7@28221|Deltaproteobacteria,2MQ3Z@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
k59_191445_2	1158165.KB898871_gene2332	3.51e-06	56.6	COG1652@1|root,COG1652@2|Bacteria,1RJQP@1224|Proteobacteria,1SCDJ@1236|Gammaproteobacteria,1X11X@135613|Chromatiales	135613|Chromatiales	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM,TPR_2,TPR_8
k59_1010539_1	28229.ND2E_3272	5.21e-41	147.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,1RMFK@1236|Gammaproteobacteria,2Q7U6@267889|Colwelliaceae	1236|Gammaproteobacteria	NT	Methyltransferase, chemotaxis proteins	cheR	GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0050896	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
k59_1313076_1	1121937.AUHJ01000009_gene1473	1.11e-112	330.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,1RXYF@1236|Gammaproteobacteria,46ABE@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	DDE domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_901926_1	1122221.JHVI01000007_gene2201	1.73e-31	127.0	COG2217@1|root,COG2217@2|Bacteria,1WJ55@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	pacS	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_24067_2	1033802.SSPSH_000347	1.35e-28	105.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,1SCXX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Phosphotransferase System	ptsO	GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006808,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009401,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050896,GO:0051179,GO:0051234,GO:0065007,GO:0071702,GO:0071704,GO:1901564,GO:1901698	-	ko:K08485,ko:K11189	ko02060,map02060	-	-	-	ko00000,ko00001,ko02000	4.A.2.1	-	-	PTS-HPr
k59_24067_3	519989.ECTPHS_01654	2.31e-17	77.0	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,1SA62@1236|Gammaproteobacteria,1WYYD@135613|Chromatiales	135613|Chromatiales	G	system, fructose subfamily IIA component	-	-	2.7.1.194	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	M00283,M00550	R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.7.1	-	-	EIIA-man
k59_257755_1	1454202.PPBDW_80220___1	1.56e-08	55.8	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RR6K@1236|Gammaproteobacteria,1XSR4@135623|Vibrionales	135623|Vibrionales	M	COG0859 ADP-heptose LPS heptosyltransferase	-	-	-	ko:K12982	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_257755_2	228410.NE1659	5.11e-11	66.2	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,2VMTY@28216|Betaproteobacteria,372DF@32003|Nitrosomonadales	28216|Betaproteobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	ko:K16291	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	YkuD
k59_1251786_1	868595.Desca_2508	3.26e-96	293.0	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,2600A@186807|Peptococcaceae	186801|Clostridia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_836810_1	349521.HCH_04984	2.69e-28	107.0	COG0517@1|root,COG0517@2|Bacteria,1QTZR@1224|Proteobacteria,1S7SY@1236|Gammaproteobacteria,1XKDN@135619|Oceanospirillales	135619|Oceanospirillales	S	COG0517 FOG CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
k59_1659374_1	913865.DOT_0314	4.67e-125	371.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	potE	-	-	ko:K16263	-	-	-	-	ko00000,ko02000	2.A.3.13	-	-	AA_permease_2
k59_80141_1	1304885.AUEY01000003_gene518	4.79e-64	199.0	COG1406@1|root,COG1406@2|Bacteria,1RATZ@1224|Proteobacteria,42R2Q@68525|delta/epsilon subdivisions,2WP6F@28221|Deltaproteobacteria,2MJQ2@213118|Desulfobacterales	28221|Deltaproteobacteria	N	Chemotaxis phosphatase CheX	-	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
k59_1010550_1	365046.Rta_16210	2.02e-06	48.9	COG2823@1|root,COG2823@2|Bacteria,1N4W2@1224|Proteobacteria,2VV7P@28216|Betaproteobacteria,4AF5E@80864|Comamonadaceae	28216|Betaproteobacteria	S	SMART Transport-associated and nodulation region	-	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON,EF-hand_5
k59_1010550_2	1120948.KB903229_gene5321	1.74e-08	60.1	COG2030@1|root,COG2030@2|Bacteria,2GNQQ@201174|Actinobacteria,4DZV4@85010|Pseudonocardiales	201174|Actinobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
k59_1659376_2	521003.COLINT_02078	1.37e-15	75.1	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4CVTB@84998|Coriobacteriia	84998|Coriobacteriia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_484426_1	768671.ThimaDRAFT_0044	1.05e-48	163.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S65T@1236|Gammaproteobacteria,1WXHS@135613|Chromatiales	135613|Chromatiales	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_484426_2	1286106.MPL1_06295	6.11e-48	155.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,1S6FN@1236|Gammaproteobacteria,460ZC@72273|Thiotrichales	72273|Thiotrichales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
k59_484426_3	1049564.TevJSym_ap00510	5.24e-41	150.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1J4U3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CP	CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	nuoL	-	1.6.5.3	ko:K00341,ko:K05559	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_1540883_1	1198452.Jab_2c01520	4.09e-165	486.0	COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,4736W@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
k59_132826_1	367299.JOEE01000006_gene897	1.4e-36	127.0	COG0315@1|root,COG0315@2|Bacteria,2IHR6@201174|Actinobacteria,4FGBG@85021|Intrasporangiaceae	201174|Actinobacteria	H	Molybdenum cofactor biosynthesis protein MoaC	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
k59_132826_2	367299.JOEE01000006_gene898	5.06e-46	152.0	COG0521@1|root,COG0521@2|Bacteria,2II28@201174|Actinobacteria,4FGHH@85021|Intrasporangiaceae	201174|Actinobacteria	H	Molybdenum cofactor synthesis protein	mog	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoaE
k59_1716849_1	1485544.JQKP01000012_gene2151	6.15e-88	280.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2VHPQ@28216|Betaproteobacteria,44VER@713636|Nitrosomonadales	28216|Betaproteobacteria	E	PFAM peptidase M3A and M3B thimet oligopeptidase F	prlC	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_1841304_1	1108045.GORHZ_169_00430	8.47e-194	563.0	COG2865@1|root,COG2865@2|Bacteria,2GZ30@201174|Actinobacteria,4GE4R@85026|Gordoniaceae	201174|Actinobacteria	K	Putative ATP-dependent DNA helicase recG C-terminal	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4,HTH_24
k59_1841304_3	1380393.JHVP01000003_gene821	1.22e-71	222.0	COG3226@1|root,COG3226@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
k59_1841304_4	1385520.N802_03020	2.45e-99	292.0	COG0110@1|root,COG0110@2|Bacteria,2GNUB@201174|Actinobacteria,4FGSD@85021|Intrasporangiaceae	201174|Actinobacteria	S	Maltose acetyltransferase	maa	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2,Mac
k59_1841304_5	1382306.JNIM01000001_gene1984	2.76e-36	135.0	COG0637@1|root,COG0637@2|Bacteria,2G6ZZ@200795|Chloroflexi	200795|Chloroflexi	O	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2,Peptidase_M22
k59_308305_1	765910.MARPU_13575	8.89e-76	237.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1WWR6@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator, LysR	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_1486823_1	1043205.AFYF01000055_gene2324	1.61e-18	92.8	COG2234@1|root,COG2234@2|Bacteria,2IDP0@201174|Actinobacteria,4FE57@85021|Intrasporangiaceae	201174|Actinobacteria	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_901973_1	590998.Celf_0238	3.44e-102	309.0	COG0181@1|root,COG0181@2|Bacteria,2GMWI@201174|Actinobacteria,4F0DP@85016|Cellulomonadaceae	201174|Actinobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0510	Porphobil_deam,Porphobil_deamC
k59_1841308_1	1121861.KB899910_gene820	9.37e-30	113.0	COG1586@1|root,COG1586@2|Bacteria,1RH88@1224|Proteobacteria,2U5D3@28211|Alphaproteobacteria,2JT4E@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speH	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
k59_601508_1	1382356.JQMP01000004_gene532	1.5e-16	77.8	COG2120@1|root,COG2120@2|Bacteria,2G6FB@200795|Chloroflexi,27XM3@189775|Thermomicrobia	189775|Thermomicrobia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
k59_601508_2	1173027.Mic7113_1043	2.36e-31	125.0	COG0438@1|root,COG0438@2|Bacteria,1G1UM@1117|Cyanobacteria,1H9FF@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_24103_1	710696.Intca_2746	8.93e-76	227.0	COG0093@1|root,COG0093@2|Bacteria,2IHNX@201174|Actinobacteria,4FGKY@85021|Intrasporangiaceae	201174|Actinobacteria	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071944,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
k59_24103_2	367299.JOEE01000001_gene2185	1.89e-59	184.0	COG0198@1|root,COG0198@2|Bacteria,2IKP2@201174|Actinobacteria,4FGY1@85021|Intrasporangiaceae	201174|Actinobacteria	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
k59_308310_1	765912.Thimo_0058	8.16e-51	171.0	COG2802@1|root,COG2802@2|Bacteria,1NV9N@1224|Proteobacteria,1SAAZ@1236|Gammaproteobacteria,1WXGU@135613|Chromatiales	135613|Chromatiales	S	peptidase S16, lon	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
k59_1077571_1	1541065.JRFE01000004_gene5294	3.32e-97	293.0	COG1230@1|root,COG1230@2|Bacteria,1G3AT@1117|Cyanobacteria	1117|Cyanobacteria	P	TIGRFAM cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
k59_484447_1	1049564.TevJSym_ao00020	4.68e-86	266.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1J4IU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	visC	-	-	ko:K03184,ko:K03185,ko:K18800	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04987,R04989,R06146,R08768,R08773,R08775	RC00046,RC01254,RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3,SE
k59_373726_1	1249627.D779_2413	1.6e-100	308.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1WVVK@135613|Chromatiales	135613|Chromatiales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_1775317_1	1239962.C943_01835	4.09e-05	51.2	COG2227@1|root,COG2227@2|Bacteria,4NFHE@976|Bacteroidetes,47JIB@768503|Cytophagia	976|Bacteroidetes	H	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_308322_1	1232410.KI421425_gene1554	1.07e-96	320.0	COG1361@1|root,COG1361@2|Bacteria,1R5G4@1224|Proteobacteria,42T0V@68525|delta/epsilon subdivisions,2WPRT@28221|Deltaproteobacteria,43TPS@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
k59_1313161_1	261292.Nit79A3_1885	2.03e-76	243.0	COG0240@1|root,COG0240@2|Bacteria,1RED0@1224|Proteobacteria,2W2AD@28216|Betaproteobacteria	28216|Betaproteobacteria	I	PFAM NAD-dependent glycerol-3-phosphate dehydrogenase	-	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_1313161_2	1249627.D779_1932	1.59e-10	59.3	COG1051@1|root,COG1051@2|Bacteria,1MWNH@1224|Proteobacteria,1S56W@1236|Gammaproteobacteria,1WYDD@135613|Chromatiales	135613|Chromatiales	F	pfam nudix	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
k59_1659418_1	1499967.BAYZ01000104_gene3654	2.56e-13	68.6	COG1723@1|root,COG1723@2|Bacteria	2|Bacteria	S	PFAM Uncharacterised ACR, YagE family COG1723	yagE	-	-	-	-	-	-	-	-	-	-	-	DUF155
k59_1659418_2	713586.KB900536_gene1554	2.6e-38	140.0	COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,1WXN5@135613|Chromatiales	135613|Chromatiales	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,DUF3335
k59_132853_1	367299.JOEE01000004_gene1018	2.63e-109	339.0	COG3119@1|root,COG3119@2|Bacteria,2H59R@201174|Actinobacteria,4FECJ@85021|Intrasporangiaceae	201174|Actinobacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_132853_2	1206732.BAGD01000086_gene3817	1.06e-06	48.9	COG0748@1|root,COG0748@2|Bacteria,2IP6Y@201174|Actinobacteria,4G3D8@85025|Nocardiaceae	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
k59_1486860_1	1336245.JAGO01000010_gene679	6.36e-27	103.0	COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,1RS1Y@1236|Gammaproteobacteria,1XI6S@135619|Oceanospirillales	135619|Oceanospirillales	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271,ko:K12961	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005,ko03036	-	-	-	SIS_2
k59_1486860_2	396588.Tgr7_0755	4.94e-98	300.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WXBN@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD linked oxidase domain protein	-	-	1.1.5.12	ko:K03777	ko00620,ko01120,map00620,map01120	-	R00704,R11591	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1841350_1	1385515.N791_02465	6.77e-62	209.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1X4XY@135614|Xanthomonadales	135614|Xanthomonadales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_1540923_1	349521.HCH_06352	6.45e-134	387.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1XI33@135619|Oceanospirillales	135619|Oceanospirillales	NU	twitching motility protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_1540923_2	1005995.GTPT_3270	1.63e-06	49.7	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,1RNPM@1236|Gammaproteobacteria,4BU5M@82986|Tatumella	1236|Gammaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
k59_1599275_1	1121875.KB907546_gene2194	6.81e-84	264.0	COG3653@1|root,COG3653@2|Bacteria,4NHDD@976|Bacteroidetes,1I2RR@117743|Flavobacteriia	976|Bacteroidetes	Q	PFAM D-aminoacylase, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_1313172_1	56780.SYN_00558	7.08e-115	348.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,2MQAG@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_1364984_1	1123504.JQKD01000027_gene4118	3.44e-45	169.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,4A9PT@80864|Comamonadaceae	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_1313174_1	1500306.JQLA01000020_gene6495	1.2e-59	197.0	COG3214@1|root,COG3214@2|Bacteria,1N40B@1224|Proteobacteria,2TT7U@28211|Alphaproteobacteria,4B77U@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
k59_543267_1	768671.ThimaDRAFT_3845	2.15e-286	820.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1WXJB@135613|Chromatiales	135613|Chromatiales	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1716887_1	1323361.JPOC01000034_gene1774	5.15e-237	674.0	COG0471@1|root,COG0471@2|Bacteria,2HISP@201174|Actinobacteria,4G4PN@85025|Nocardiaceae	201174|Actinobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_1599278_1	713587.THITH_14535	7.23e-106	321.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WXBN@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD linked oxidase domain protein	-	-	1.1.5.12	ko:K03777	ko00620,ko01120,map00620,map01120	-	R00704,R11591	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_968836_1	1120959.ATXF01000010_gene19	4.59e-86	276.0	COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,2GMX7@201174|Actinobacteria,4FMZM@85023|Microbacteriaceae	201174|Actinobacteria	G	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor	otsA	GO:0003674,GO:0003824,GO:0003825,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0030312,GO:0033554,GO:0034637,GO:0035251,GO:0040007,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0046872,GO:0046914,GO:0047260,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:0071944,GO:1901576	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,Trehalose_PPase
k59_1546435_1	670307.HYPDE_41848	2.57e-63	197.0	COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,2UBVU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0607 Rhodanese-related sulfurtransferase	pspE	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_548614_1	1267005.KB911260_gene3459	4.07e-19	90.1	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2TRWK@28211|Alphaproteobacteria,3N68K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_1493579_1	247490.KSU1_A0059	3.27e-73	234.0	COG2148@1|root,COG2148@2|Bacteria,2IYWX@203682|Planctomycetes	203682|Planctomycetes	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
k59_1781024_1	84531.JMTZ01000021_gene3798	7.82e-12	70.5	COG3166@1|root,COG3166@2|Bacteria,1RJTG@1224|Proteobacteria,1S6RT@1236|Gammaproteobacteria,1X4P5@135614|Xanthomonadales	135614|Xanthomonadales	NU	General secretion pathway protein	xpsL	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	PilN,T2SSL
k59_490073_1	1150864.MILUP08_43931	1.33e-85	254.0	2F37X@1|root,33Z9D@2|Bacteria,2GW1H@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_490073_2	1150864.MILUP08_43930	5.25e-23	96.3	2DFZM@1|root,2ZTVH@2|Bacteria,2HBAW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_968851_1	1123401.JHYQ01000013_gene671	6.22e-09	56.6	COG4307@1|root,COG4307@2|Bacteria,1MW31@1224|Proteobacteria,1RRA7@1236|Gammaproteobacteria,45ZRQ@72273|Thiotrichales	72273|Thiotrichales	S	Putative zinc-binding metallo-peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx
k59_968851_2	765914.ThisiDRAFT_1546	1.21e-48	164.0	COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,1RRR0@1236|Gammaproteobacteria,1WY0S@135613|Chromatiales	135613|Chromatiales	O	PFAM 20S proteasome, A and B subunits	-	-	-	ko:K07395	-	-	-	-	ko00000	-	-	-	Proteasome
k59_196961_1	204669.Acid345_3622	4.35e-06	54.7	COG1074@1|root,COG1074@2|Bacteria,3Y41J@57723|Acidobacteria,2JI35@204432|Acidobacteriia	204432|Acidobacteriia	L	Belongs to the helicase family. UvrD subfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1430320_1	1385517.N800_11190	1.15e-28	117.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,1X3Q2@135614|Xanthomonadales	135614|Xanthomonadales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
k59_490079_1	340177.Cag_0616	3.96e-05	51.6	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Big_3_2,CHU_C,Flg_new,LRR_5
k59_266709_1	1449068.JMLQ01000002_gene3130	3.33e-47	173.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2GKI9@201174|Actinobacteria,4FU1X@85025|Nocardiaceae	201174|Actinobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_666623_1	1267005.KB911255_gene2453	1.13e-106	319.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2TQSI@28211|Alphaproteobacteria,3N63A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_1321101_1	1122179.KB890426_gene3975	1.49e-48	172.0	COG4670@1|root,COG4670@2|Bacteria,4NIRA@976|Bacteroidetes	976|Bacteroidetes	I	Coenzyme A transferase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_trans
k59_1133629_1	670307.HYPDE_36768	3.57e-142	419.0	COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,2TRPY@28211|Alphaproteobacteria,3N65U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	oligoendopeptidase	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
k59_88046_1	1249627.D779_1965	2.35e-74	239.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,1T2DW@1236|Gammaproteobacteria,1X2PB@135613|Chromatiales	135613|Chromatiales	EQ	PFAM Hydantoinase B oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_1722577_1	670307.HYPDE_24503	1.85e-73	228.0	COG0625@1|root,COG0625@2|Bacteria,1MXM4@1224|Proteobacteria,2TTXD@28211|Alphaproteobacteria,3N6WM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	glutathione S-transferase	gst	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_C_3,GST_N_3
k59_490084_2	640512.BC1003_4717	1.24e-84	263.0	COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,2VYFJ@28216|Betaproteobacteria,1K4C2@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Radical SAM superfamily	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_909876_1	335543.Sfum_4074	4.44e-150	434.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42MSQ@68525|delta/epsilon subdivisions,2WISJ@28221|Deltaproteobacteria,2MR7M@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK-1	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
k59_266727_1	298653.Franean1_3719	1.59e-68	217.0	COG0119@1|root,COG0119@2|Bacteria,2GKTP@201174|Actinobacteria,4ES54@85013|Frankiales	201174|Actinobacteria	E	PFAM Pyruvate carboxyltransferase	-	-	4.1.3.4,4.1.3.46	ko:K01640,ko:K18314	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090,R10674	RC00502,RC00503,RC01118,RC01205,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
k59_1493605_1	765912.Thimo_3352	6.56e-192	538.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1Q7PK@1224|Proteobacteria,1RSF0@1236|Gammaproteobacteria,1WWA3@135613|Chromatiales	135613|Chromatiales	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_29,HTH_33
k59_33047_1	1349820.M707_12980	4.34e-42	154.0	COG3501@1|root,COG3501@2|Bacteria,2HGNZ@201174|Actinobacteria,1WAA4@1268|Micrococcaceae	201174|Actinobacteria	S	Rhs element vgr protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_base_V
k59_1084924_2	1283300.ATXB01000001_gene479	5.32e-28	112.0	COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,1XDS7@135618|Methylococcales	135618|Methylococcales	M	Sucrose phosphate synthase, sucrose phosphatase-like	-	-	2.4.1.14	ko:K00696	ko00500,ko01100,map00500,map01100	-	R00766	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1,S6PP
k59_1133639_2	1121930.AQXG01000015_gene1870	3.19e-27	110.0	COG0534@1|root,COG0534@2|Bacteria,4NEBB@976|Bacteroidetes,1IPQM@117747|Sphingobacteriia	976|Bacteroidetes	V	efflux protein, MATE family	norM	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
k59_490092_1	1713.JOFV01000010_gene1174	4.82e-67	221.0	COG0787@1|root,COG0787@2|Bacteria,2GM2Y@201174|Actinobacteria,4F0UR@85016|Cellulomonadaceae	201174|Actinobacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_842514_1	1304865.JAGF01000001_gene1301	8.09e-76	232.0	COG1847@1|root,COG1847@2|Bacteria,2GPZK@201174|Actinobacteria,4F17N@85016|Cellulomonadaceae	201174|Actinobacteria	S	SMART single-stranded nucleic acid binding R3H	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	KH_4,R3H
k59_1493612_1	1499685.CCFJ01000041_gene823	2.54e-10	64.3	COG0664@1|root,COG0664@2|Bacteria,1U9VC@1239|Firmicutes,4HBWK@91061|Bacilli,1ZBJG@1386|Bacillus	91061|Bacilli	T	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	ko:K21562	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_1370573_1	471853.Bcav_3269	4.47e-166	478.0	COG0168@1|root,COG0168@2|Bacteria,2GKKS@201174|Actinobacteria	201174|Actinobacteria	P	Potassium uptake protein	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_33068_1	497964.CfE428DRAFT_1447	4.46e-56	197.0	COG0265@1|root,COG0823@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2234@2|Bacteria,46T85@74201|Verrucomicrobia	74201|Verrucomicrobia	OU	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,PD40,PDZ_2,Peptidase_M28
k59_1665228_1	1379270.AUXF01000007_gene1035	8.49e-47	159.0	2DM5T@1|root,31U0Y@2|Bacteria,1ZUND@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
k59_1665228_2	1500893.JQNB01000001_gene752	7.71e-08	54.7	COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,1RP0Y@1236|Gammaproteobacteria,1X4JM@135614|Xanthomonadales	135614|Xanthomonadales	L	nadh pyrophosphatase	nudC	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
k59_1133651_1	1123053.AUDG01000074_gene1788	1.65e-41	143.0	COG0671@1|root,COG0671@2|Bacteria,1RIRR@1224|Proteobacteria,1T0AG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	phosphoesterase, PA-phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
k59_1133651_2	1123368.AUIS01000019_gene1198	3.39e-30	109.0	COG2154@1|root,COG2154@2|Bacteria,1RH99@1224|Proteobacteria,1SAUS@1236|Gammaproteobacteria,2ND7I@225057|Acidithiobacillales	225057|Acidithiobacillales	H	pterin-4-alpha-carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
k59_842520_1	946483.Cenrod_1459	2.41e-120	360.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,2VJUV@28216|Betaproteobacteria,4AC86@80864|Comamonadaceae	28216|Betaproteobacteria	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_1195319_1	631362.Thi970DRAFT_02763	4.23e-39	138.0	COG3568@1|root,COG3568@2|Bacteria,1RBWV@1224|Proteobacteria,1RYBE@1236|Gammaproteobacteria,1X2D8@135613|Chromatiales	135613|Chromatiales	L	PFAM Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_266763_1	644282.Deba_0066	2.54e-40	148.0	COG2203@1|root,COG4251@1|root,COG2203@2|Bacteria,COG4251@2|Bacteria,1RGKE@1224|Proteobacteria,43EF4@68525|delta/epsilon subdivisions,2X87I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	SMART ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_842527_1	1502850.FG91_03019	3.49e-06	55.1	COG4773@1|root,COG4773@2|Bacteria,1N14Z@1224|Proteobacteria,2U112@28211|Alphaproteobacteria,2KEP0@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_490110_1	717785.HYPMC_4614	1.08e-62	193.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U952@28211|Alphaproteobacteria,3N8IE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Belongs to the P(II) protein family	glnK	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
k59_490110_2	991905.SL003B_0244	1.46e-08	55.8	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,4BPT6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	ammonium transporter, marine subtype	amt_1	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_431290_1	367299.JOEE01000001_gene2175	1.71e-114	332.0	COG0088@1|root,COG0088@2|Bacteria,2GJYJ@201174|Actinobacteria,4FEFG@85021|Intrasporangiaceae	201174|Actinobacteria	J	Forms part of the polypeptide exit tunnel	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_431290_2	367299.JOEE01000001_gene2174	7.4e-07	49.3	COG0087@1|root,COG0087@2|Bacteria,2GJXT@201174|Actinobacteria,4FECG@85021|Intrasporangiaceae	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_88118_1	1304865.JAGF01000001_gene2394	4.72e-82	266.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria	201174|Actinobacteria	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_607361_1	367299.JOEE01000011_gene3141	1.96e-121	358.0	COG1109@1|root,COG1109@2|Bacteria,2GN87@201174|Actinobacteria,4FECR@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	GO:0008150,GO:0040007	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1259188_1	1089544.KB912942_gene2743	2.03e-76	243.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DXK8@85010|Pseudonocardiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_1084971_1	1397528.Q671_16175	2.53e-119	373.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1XNKT@135619|Oceanospirillales	135619|Oceanospirillales	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1430383_1	489825.LYNGBM3L_01470	3.95e-18	88.6	COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1FZWQ@1117|Cyanobacteria,1H9CE@1150|Oscillatoriales	1117|Cyanobacteria	KLT	CHASE2 domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,Pkinase
k59_1781083_1	1173264.KI913949_gene2084	1.17e-06	51.2	COG1846@1|root,COG1846@2|Bacteria,1G61S@1117|Cyanobacteria	1117|Cyanobacteria	K	Transcriptional regulator, MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
k59_1370600_1	1123319.AUBE01000014_gene5425	3.85e-96	288.0	COG1028@1|root,COG1028@2|Bacteria,2GK20@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_909954_1	519989.ECTPHS_06707	1.36e-17	80.9	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_909954_2	1454004.AW11_03269	6.27e-316	877.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2VGZZ@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_1493655_1	999141.GME_00025	3.05e-31	124.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RP0T@1236|Gammaproteobacteria,1XJRK@135619|Oceanospirillales	135619|Oceanospirillales	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
k59_1723295_1	595460.RRSWK_03512	7.81e-58	203.0	COG0841@1|root,COG0841@2|Bacteria,2J2CE@203682|Planctomycetes	203682|Planctomycetes	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_34309_1	590998.Celf_2944	5.03e-51	173.0	COG0388@1|root,COG0388@2|Bacteria,2GMQA@201174|Actinobacteria,4F0U1@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
k59_1371181_2	697282.Mettu_1136	2.79e-18	81.6	COG4969@1|root,COG4969@2|Bacteria,1N71K@1224|Proteobacteria,1SCYD@1236|Gammaproteobacteria,1XFGK@135618|Methylococcales	135618|Methylococcales	NU	Domain of unknown function (DUF4845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4845
k59_267945_1	9365.XP_007524958.1	9.65e-34	137.0	COG0339@1|root,KOG2089@2759|Eukaryota,38SFI@33154|Opisthokonta,3B98M@33208|Metazoa,3CT8Z@33213|Bilateria,47ZCM@7711|Chordata,492KW@7742|Vertebrata,3J5Q1@40674|Mammalia	33208|Metazoa	O	thimet oligopeptidase	THOP1	GO:0000209,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005829,GO:0006464,GO:0006508,GO:0006518,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0016567,GO:0016787,GO:0019538,GO:0023052,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032446,GO:0033218,GO:0034641,GO:0035556,GO:0036211,GO:0042277,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0070013,GO:0070647,GO:0071704,GO:0140096,GO:1901564	3.4.24.15,3.4.24.16	ko:K01392,ko:K01393	ko04614,ko05143,map04614,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M3
k59_970029_1	406124.ACPC01000022_gene4291	6.31e-06	51.6	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,4H9MW@91061|Bacilli,1ZBKI@1386|Bacillus	91061|Bacilli	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_490730_1	95619.PM1_0202175	8.08e-85	265.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
k59_490730_2	1121935.AQXX01000133_gene3506	5.86e-128	371.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1XH7U@135619|Oceanospirillales	135619|Oceanospirillales	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_267947_1	43759.JNWK01000004_gene1065	7.5e-75	253.0	COG4987@1|root,COG4988@1|root,COG4987@2|Bacteria,COG4988@2|Bacteria,2I2DP@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter CydDC cysteine exporter (CydDC-E) family permease ATP-binding protein CydD	cydD	-	-	ko:K16013,ko:K16014	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.129	-	-	ABC_membrane,ABC_tran
k59_1723303_1	631362.Thi970DRAFT_02302	1.73e-90	288.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1850488_1	1249627.D779_2627	6.17e-119	354.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1WVXY@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_1322278_1	1306174.JODP01000009_gene6539	1.24e-57	196.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome b	qcrB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03891	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_N_2
k59_1850498_2	305700.B447_03678	4.63e-67	207.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2VIQP@28216|Betaproteobacteria,2KUR2@206389|Rhodocyclales	206389|Rhodocyclales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
k59_490747_1	1267533.KB906733_gene2863	8.37e-24	104.0	COG2984@1|root,COG4585@1|root,COG2984@2|Bacteria,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07683	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	ABC_sub_bind,GAF_2,HATPase_c,HisKA,HisKA_3,PAS_3,PAS_9
k59_970061_1	266940.Krad_3149	6.37e-64	204.0	COG1189@1|root,COG1189@2|Bacteria,2GJVT@201174|Actinobacteria	201174|Actinobacteria	J	Ribosomal RNA methyltransferase RrmJ FtsJ	tlyA	GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
k59_843252_1	1049564.TevJSym_ca00030	3.45e-19	92.4	COG0419@1|root,COG1121@1|root,COG0419@2|Bacteria,COG1121@2|Bacteria	2|Bacteria	P	zinc-transporting ATPase activity	-	-	-	ko:K03546,ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000,ko03400	3.A.1.15.3,3.A.1.15.5	-	-	AAA_23,ABC_tran,SbcCD_C
k59_549340_2	391735.Veis_3074	8.05e-10	57.8	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2VSVW@28216|Betaproteobacteria,4ADW4@80864|Comamonadaceae	28216|Betaproteobacteria	U	PFAM Biopolymer transport protein ExbD TolR	exbD1	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_1431093_1	1216007.AOPM01000028_gene3559	2.11e-26	102.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,2Q074@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	J	Forms part of the polypeptide exit tunnel	rplD	GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003700,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008428,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030234,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032069,GO:0032074,GO:0032268,GO:0032269,GO:0032991,GO:0032993,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065003,GO:0065007,GO:0065009,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:0098772,GO:0140110,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990904,GO:2000112,GO:2000113,GO:2001141	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_1431093_2	998088.B565_0185	7.07e-30	109.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,1S8VX@1236|Gammaproteobacteria,1Y4G5@135624|Aeromonadales	135624|Aeromonadales	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_197640_1	338966.Ppro_2770	8.53e-26	107.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,43S9K@69541|Desulfuromonadales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.34	ko:K00666,ko:K12508	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_382808_1	640081.Dsui_0313	9.4e-13	65.1	COG0457@1|root,COG0457@2|Bacteria,1QV07@1224|Proteobacteria,2WGNZ@28216|Betaproteobacteria,2KZQF@206389|Rhodocyclales	206389|Rhodocyclales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_382808_2	314278.NB231_10778	1.18e-94	283.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1RSPA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_34371_1	272558.10175292	1.12e-54	187.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,4H9WK@91061|Bacilli,1ZC02@1386|Bacillus	91061|Bacilli	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1850513_1	670292.JH26_23010	4.61e-61	201.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2TREV@28211|Alphaproteobacteria,1JXM4@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	UDP binding domain	algD	-	1.1.1.132	ko:K00066	ko00051,ko00520,ko02020,map00051,map00520,map02020	-	R00880	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_267997_1	1049564.TevJSym_ad01660	3.27e-114	351.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1J4J1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Cytochrome c-type biogenesis protein	ccmF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_1090151_2	517417.Cpar_0681	3.19e-30	108.0	2DNFB@1|root,32X7Q@2|Bacteria,1FE3W@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_201278_1	314285.KT71_02187	5.78e-62	204.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,1J9B6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
k59_39753_1	247634.GPB2148_2212	3e-29	114.0	COG0438@1|root,COG0438@2|Bacteria,1MZH2@1224|Proteobacteria,1S9AM@1236|Gammaproteobacteria,1JB0Z@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Glycosyl transferase, group 1	-	-	2.4.1.346	ko:K13668	-	-	R11703,R11704	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
k59_1199749_1	1126627.BAWE01000005_gene6111	5.83e-54	191.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_1374711_1	1242864.D187_000026	4.47e-26	105.0	COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,42QBB@68525|delta/epsilon subdivisions,2WKEZ@28221|Deltaproteobacteria,2YU90@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1374711_2	1449357.JQLK01000001_gene521	3.04e-40	144.0	COG1804@1|root,COG1804@2|Bacteria,1WIR7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_142745_2	1095767.CAHD01000046_gene1417	6.54e-24	97.8	COG3981@1|root,COG3981@2|Bacteria,2IGK9@201174|Actinobacteria	201174|Actinobacteria	L	Gcn5-related n-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3
k59_319345_1	1123368.AUIS01000010_gene2370	4.62e-07	50.8	COG4798@1|root,COG4798@2|Bacteria,1QUNP@1224|Proteobacteria,1S3N0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_319345_2	768671.ThimaDRAFT_0614	1.48e-58	194.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,1WXGI@135613|Chromatiales	135613|Chromatiales	M	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	ko:K16291	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	SPOR,YkuD
k59_612380_1	743836.AYNA01000089_gene3312	2.74e-91	274.0	COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,2TRTM@28211|Alphaproteobacteria,36Y00@31993|Methylocystaceae	28211|Alphaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	3.7.1.20	ko:K16165	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R01085	RC00326,RC00446	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
k59_1090704_1	216595.PFLU_5223	4.6e-61	209.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1YP0I@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
k59_1499220_1	1120956.JHZK01000031_gene172	1.42e-41	142.0	COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,2U78A@28211|Alphaproteobacteria,1JNUY@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	SNARE associated Golgi protein	dedA	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_1330211_1	399739.Pmen_3652	1.74e-10	64.3	COG2207@1|root,COG2207@2|Bacteria,1RH01@1224|Proteobacteria,1S57M@1236|Gammaproteobacteria,1YF4A@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	K	Transcriptional regulator	oruR	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_1330211_2	748247.AZKH_1954	1.08e-09	58.2	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria	1224|Proteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1138157_1	748247.AZKH_2496	3.26e-63	216.0	COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,2VPRW@28216|Betaproteobacteria,2KYK5@206389|Rhodocyclales	206389|Rhodocyclales	M	Protein of unknown function (DUF1302)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1302
k59_1609333_1	880072.Desac_1532	3.19e-41	144.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,42TAG@68525|delta/epsilon subdivisions,2X5C6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_1200337_1	1122622.ATWJ01000008_gene2607	5.96e-79	251.0	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,2IASU@201174|Actinobacteria,4FJXN@85021|Intrasporangiaceae	201174|Actinobacteria	IT	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
k59_1019635_1	349124.Hhal_1070	1.14e-142	417.0	COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,1RPQN@1236|Gammaproteobacteria,1WWIP@135613|Chromatiales	135613|Chromatiales	S	2-methylcitrate dehydratase	prpD	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
k59_1609335_2	644801.Psest_3232	2.32e-07	49.3	2EGSV@1|root,33AIZ@2|Bacteria,1NGPG@1224|Proteobacteria,1SGM3@1236|Gammaproteobacteria,1Z3I3@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Cysteine-rich CPXCG	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_CPXG
k59_1200344_2	545276.KB898724_gene1763	1.36e-27	111.0	COG0247@1|root,COG0277@1|root,COG0479@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG0479@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales	135613|Chromatiales	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_978007_1	255470.cbdbA889	2.97e-20	86.7	COG0177@1|root,COG0177@2|Bacteria,2G6A1@200795|Chloroflexi,34D9Y@301297|Dehalococcoidia	301297|Dehalococcoidia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_978007_2	1047013.AQSP01000064_gene1485	5.71e-41	145.0	COG1180@1|root,COG1180@2|Bacteria,2NP82@2323|unclassified Bacteria	2|Bacteria	O	Radical SAM superfamily	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_40427_1	999141.GME_14370	5.91e-100	306.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1XITD@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_1375275_1	1089552.KI911559_gene294	2.06e-73	239.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2JPA1@204441|Rhodospirillales	204441|Rhodospirillales	P	COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1499238_1	525897.Dbac_0222	1.98e-39	146.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1200349_1	56780.SYN_03210	6.68e-48	159.0	COG3335@1|root,COG3335@2|Bacteria,1N5WI@1224|Proteobacteria,42R7X@68525|delta/epsilon subdivisions,2WQV8@28221|Deltaproteobacteria,2MRUD@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_97155_1	1214242.B446_09560	2.46e-25	103.0	COG0488@1|root,COG0488@2|Bacteria,2GKQ4@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	ybiT	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn,DLIC
k59_97155_2	1386089.N865_03400	2.98e-39	135.0	COG2867@1|root,COG2867@2|Bacteria,2HY4C@201174|Actinobacteria,4FJQW@85021|Intrasporangiaceae	201174|Actinobacteria	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
k59_918924_1	243233.MCA2164	5.31e-99	317.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,1XG1J@135618|Methylococcales	135618|Methylococcales	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1200351_1	1167006.UWK_00758	3.57e-88	285.0	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MX08@1224|Proteobacteria,42MS6@68525|delta/epsilon subdivisions,2WIYE@28221|Deltaproteobacteria,2MJNV@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_1330249_1	404589.Anae109_4061	4.59e-148	440.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,42P3R@68525|delta/epsilon subdivisions,2X349@28221|Deltaproteobacteria,2YU6W@29|Myxococcales	28221|Deltaproteobacteria	H	Malate synthase	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_671565_1	1117647.M5M_09250	1.61e-67	217.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria,1J4Z3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon	birA	GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
k59_847568_1	443255.SCLAV_0475	2.19e-20	92.4	COG1944@1|root,COG1944@2|Bacteria,2GKBS@201174|Actinobacteria	201174|Actinobacteria	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	ThiF,YcaO
k59_1609354_1	298655.KI912266_gene2902	6.15e-06	54.7	COG2374@1|root,COG2374@2|Bacteria,2GNED@201174|Actinobacteria,4ETH2@85013|Frankiales	201174|Actinobacteria	L	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_143333_1	156889.Mmc1_2196	1.31e-07	60.1	COG2931@1|root,COG3210@1|root,COG3827@1|root,COG4447@1|root,COG4625@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3827@2|Bacteria,COG4447@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4347,He_PIG,HemolysinCabind,VWA_2
k59_918937_1	318161.Sden_2282	7.35e-36	131.0	COG3132@1|root,COG3132@2|Bacteria,1RA13@1224|Proteobacteria,1RQUQ@1236|Gammaproteobacteria,2QBUG@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Belongs to the UPF0502 family	yceH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480
k59_918937_2	1381123.AYOD01000008_gene3217	1.48e-09	60.1	COG5331@1|root,COG5331@2|Bacteria,1N7DJ@1224|Proteobacteria,2U7D2@28211|Alphaproteobacteria,43KWP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
k59_918937_3	1415778.JQMM01000001_gene1460	1.8e-10	58.2	COG2900@1|root,COG2900@2|Bacteria	2|Bacteria	S	Belongs to the SlyX family	slyX	-	-	ko:K03745	-	-	-	-	ko00000	-	-	-	SlyX
k59_918937_4	747.DR93_1718	4.39e-05	47.8	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,1Y7FS@135625|Pasteurellales	135625|Pasteurellales	S	ABC transporter, ATP-binding protein	uup-A	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_1090746_2	765912.Thimo_0103	4.9e-114	352.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WVYX@135613|Chromatiales	135613|Chromatiales	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_40463_1	1463936.JOJI01000017_gene7467	2.35e-59	207.0	COG0768@1|root,COG0768@2|Bacteria,2GKHH@201174|Actinobacteria	201174|Actinobacteria	M	penicillin-binding protein	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
k59_978061_1	590998.Celf_1034	1.84e-23	97.8	COG0101@1|root,COG0101@2|Bacteria,2GJ6C@201174|Actinobacteria,4F0W6@85016|Cellulomonadaceae	201174|Actinobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_978061_2	1304865.JAGF01000001_gene1955	2.26e-08	55.8	2E6NT@1|root,33198@2|Bacteria,2IFTP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1375306_1	1095767.CAHD01000193_gene175	1.44e-68	222.0	COG0327@1|root,COG0327@2|Bacteria,2GKHZ@201174|Actinobacteria,4F0E5@85016|Cellulomonadaceae	201174|Actinobacteria	S	Belongs to the GTP cyclohydrolase I type 2 NIF3 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	NIF3
k59_1435460_3	1198232.CYCME_2072	4.86e-46	149.0	2CDMX@1|root,32S1K@2|Bacteria,1N1I8@1224|Proteobacteria,1S9N4@1236|Gammaproteobacteria,4630G@72273|Thiotrichales	72273|Thiotrichales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_97212_1	471853.Bcav_1172	3.94e-71	227.0	COG1482@1|root,COG1482@2|Bacteria,2GJXC@201174|Actinobacteria	201174|Actinobacteria	G	mannose-6-phosphate isomerase	manA	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
k59_978082_1	335543.Sfum_1005	2.49e-50	181.0	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,42MX2@68525|delta/epsilon subdivisions,2WIUV@28221|Deltaproteobacteria,2MR6B@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_201911_1	706587.Desti_1834	2.17e-20	92.4	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,42NFP@68525|delta/epsilon subdivisions,2WK64@28221|Deltaproteobacteria,2MQZU@213462|Syntrophobacterales	28221|Deltaproteobacteria	EQ	Hydantoinase/oxoprolinase N-terminal region	hyuA	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k59_201911_2	706587.Desti_1835	2.36e-36	135.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,43CGH@68525|delta/epsilon subdivisions,2WJ3J@28221|Deltaproteobacteria,2MS4N@213462|Syntrophobacterales	28221|Deltaproteobacteria	EQ	Hydantoinase B/oxoprolinase	hyuB	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_553758_1	384765.SIAM614_26406	8.86e-91	279.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2015, Alkyl sulfatase and related hydrolases	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_1090777_1	1244869.H261_00665	3.91e-12	66.2	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,2JQGN@204441|Rhodospirillales	204441|Rhodospirillales	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_1090777_2	748247.AZKH_0601	4.1e-31	121.0	COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,2VQCX@28216|Betaproteobacteria,2KYUF@206389|Rhodocyclales	206389|Rhodocyclales	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
k59_847600_2	572477.Alvin_2710	1.26e-14	69.7	2ED4J@1|root,338UZ@2|Bacteria,1N9XK@1224|Proteobacteria,1SEC5@1236|Gammaproteobacteria,1WZI3@135613|Chromatiales	135613|Chromatiales	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp
k59_1435469_1	765912.Thimo_3397	1.06e-174	504.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1WX8S@135613|Chromatiales	135613|Chromatiales	P	PFAM phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_1727827_1	713586.KB900536_gene2120	9.47e-114	345.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1WW41@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_390701_1	859657.RPSI07_2820	7.7e-11	65.1	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1K3N3@119060|Burkholderiaceae	28216|Betaproteobacteria	JKL	DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlE	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_40514_1	1149133.ppKF707_6180	6.7e-38	145.0	COG0247@1|root,COG0277@1|root,COG0479@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG0479@2|Bacteria,1MU6Y@1224|Proteobacteria,1RM7Z@1236|Gammaproteobacteria,1YD2R@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	FAD linked oxidases, C-terminal domain	lldE	-	-	ko:K18930	-	-	-	-	ko00000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_7,Fer4_8
k59_97259_1	574966.KB898646_gene3373	9.47e-43	147.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,1RNKT@1236|Gammaproteobacteria,1XJAC@135619|Oceanospirillales	135619|Oceanospirillales	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
k59_97259_2	1122134.KB893651_gene2217	3.99e-09	57.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1XHWP@135619|Oceanospirillales	135619|Oceanospirillales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_495154_1	1229276.DI53_1445	2.7e-70	235.0	COG0339@1|root,COG0339@2|Bacteria,4NFYA@976|Bacteroidetes,1IQNS@117747|Sphingobacteriia	976|Bacteroidetes	E	peptidase	-	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_847614_1	1121405.dsmv_1320	3.23e-99	313.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MIZ3@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1670384_1	717606.PaecuDRAFT_2105	4.29e-35	134.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,4HA9K@91061|Bacilli,26RXB@186822|Paenibacillaceae	91061|Bacilli	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_273754_2	338963.Pcar_1580	1.21e-28	114.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria,43TYZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_4,PAS_9,Sigma54_activat
k59_784800_1	1123368.AUIS01000004_gene256	1.17e-80	258.0	COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,2NBTV@225057|Acidithiobacillales	225057|Acidithiobacillales	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB	hscA	-	-	ko:K04044	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
k59_1019689_1	870187.Thini_1186	2.42e-172	483.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,1RN7C@1236|Gammaproteobacteria,45ZUF@72273|Thiotrichales	72273|Thiotrichales	S	PFAM AAA domain (dynein-related subfamily)	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
k59_1019689_2	472759.Nhal_3438	1.53e-33	129.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,1X257@135613|Chromatiales	135613|Chromatiales	P	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
k59_40524_1	472759.Nhal_1615	1.89e-66	215.0	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,1RP1B@1236|Gammaproteobacteria,1WZVK@135613|Chromatiales	135613|Chromatiales	C	Prokaryotic cytochrome b561	-	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
k59_273763_1	1121861.KB899925_gene2504	6.41e-44	155.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,2JQ6Q@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_273763_2	1110502.TMO_0185	3.06e-11	63.9	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,2JPK2@204441|Rhodospirillales	204441|Rhodospirillales	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_273764_1	224325.AF_0662	1.1e-33	135.0	COG1148@1|root,COG1908@1|root,arCOG02235@2157|Archaea,arCOG02475@2157|Archaea,2XT3X@28890|Euryarchaeota,245U1@183980|Archaeoglobi	183980|Archaeoglobi	C	Heterodisulfide reductase subunit A and related polyferredoxins	-	-	-	ko:K16886	-	-	-	-	ko00000	-	-	-	Fer4,FlpD,Pyr_redox_2
k59_201946_1	1304885.AUEY01000040_gene1606	1.97e-56	189.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,42NI6@68525|delta/epsilon subdivisions,2WKI1@28221|Deltaproteobacteria,2MJDX@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_495170_1	1122603.ATVI01000006_gene779	2.9e-39	143.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RPMN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	lipopolysaccharide heptosyltransferase I	rfaC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K02841	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	iB21_1397.B21_03429,iECBD_1354.ECBD_0105,iECB_1328.ECB_03478,iECD_1391.ECD_03478,iECNA114_1301.ECNA114_3774,iECSF_1327.ECSF_3456,iSF_1195.SF3661,iS_1188.S4107	Glyco_transf_9
k59_612474_1	1158292.JPOE01000005_gene640	5.16e-08	52.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2VQ63@28216|Betaproteobacteria,1KJDX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_612474_2	765914.ThisiDRAFT_2609	2.94e-75	226.0	COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,1S3WB@1236|Gammaproteobacteria,1WYAY@135613|Chromatiales	135613|Chromatiales	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
k59_919055_1	1168034.FH5T_00855	2.03e-85	271.0	COG5434@1|root,COG5434@2|Bacteria,4NG9X@976|Bacteroidetes,2FP9N@200643|Bacteroidia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28,Pectate_lyase_3
k59_40538_2	1313421.JHBV01000031_gene1345	3.59e-29	112.0	COG3967@1|root,COG3967@2|Bacteria,4NJDN@976|Bacteroidetes,1IS2M@117747|Sphingobacteriia	976|Bacteroidetes	M	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K14189	-	-	-	-	ko00000,ko01000	-	-	-	adh_short
k59_1200427_1	2340.JV46_26640	1.69e-81	269.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5KS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1733013_1	1216966.BAUC01000019_gene819	2.43e-100	317.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_1556591_1	335543.Sfum_1590	9.85e-115	344.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria,2MR5R@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_677182_1	1463895.JODA01000054_gene3991	1.34e-94	295.0	COG2015@1|root,COG2015@2|Bacteria,2GK38@201174|Actinobacteria	201174|Actinobacteria	Q	COG2015 Alkyl sulfatase and related hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_1614818_1	1173024.KI912149_gene5494	9.16e-60	214.0	COG1075@1|root,COG4249@1|root,COG1075@2|Bacteria,COG4249@2|Bacteria,1G42B@1117|Cyanobacteria,1JJ83@1189|Stigonemataceae	1117|Cyanobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	LCAT,Peptidase_C14
k59_1380763_1	349521.HCH_02040	4.6e-31	116.0	COG0575@1|root,COG0575@2|Bacteria,1N4I3@1224|Proteobacteria,1SASF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	COG0575 CDP-diglyceride synthetase	-	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
k59_1505451_1	546274.EIKCOROL_01920	1.2e-06	50.8	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,2KPNM@206351|Neisseriales	206351|Neisseriales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_1505451_2	323261.Noc_1194	1.47e-61	193.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,1S4H7@1236|Gammaproteobacteria,1WYAR@135613|Chromatiales	135613|Chromatiales	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_1505451_3	765913.ThidrDRAFT_0292	1.44e-27	107.0	COG2913@1|root,COG2913@2|Bacteria,1N6YW@1224|Proteobacteria,1SCTT@1236|Gammaproteobacteria,1WZIB@135613|Chromatiales	135613|Chromatiales	J	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamE	-	-	ko:K06186	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	SmpA_OmlA
k59_148893_1	795666.MW7_2475	6.1e-61	199.0	COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,2VJ7T@28216|Betaproteobacteria,1K1P1@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Periplasmic binding protein	btuF	-	-	ko:K02016,ko:K06858	ko02010,map02010	M00240,M00241	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.13,3.A.1.14	-	-	Peripla_BP_2
k59_148893_2	768671.ThimaDRAFT_4240	3.73e-85	259.0	COG1893@1|root,COG1893@2|Bacteria,1R60C@1224|Proteobacteria,1RZQZ@1236|Gammaproteobacteria,1WXZX@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1556595_1	765910.MARPU_10885	1e-78	241.0	COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,1RYZ2@1236|Gammaproteobacteria,1WW9H@135613|Chromatiales	135613|Chromatiales	C	PFAM Nitrate reductase gamma subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_gam
k59_281094_1	247634.GPB2148_3038	1.89e-52	169.0	COG2030@1|root,COG2030@2|Bacteria	2|Bacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
k59_1271094_1	1049564.TevJSym_ap00410	1e-111	342.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1J4NM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_1271094_2	1437609.BCAL_1214	3.77e-27	100.0	COG0184@1|root,COG0184@2|Bacteria,2IQA0@201174|Actinobacteria,4D10E@85004|Bifidobacteriales	201174|Actinobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
k59_1556597_1	349521.HCH_05238	2.3e-67	218.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1XHF6@135619|Oceanospirillales	135619|Oceanospirillales	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
k59_207438_1	1232437.KL661969_gene4965	1.44e-12	64.3	2EGBG@1|root,33A3B@2|Bacteria,1NG8F@1224|Proteobacteria,42X8P@68525|delta/epsilon subdivisions,2WT4B@28221|Deltaproteobacteria,2MMFP@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_207438_2	1121405.dsmv_1593	7.86e-43	146.0	COG0781@1|root,COG0781@2|Bacteria,1N94P@1224|Proteobacteria,42SEA@68525|delta/epsilon subdivisions,2WQP9@28221|Deltaproteobacteria,2MK59@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
k59_1024126_1	864051.BurJ1DRAFT_1697	1.51e-104	314.0	COG0584@1|root,COG0584@2|Bacteria,1MVWZ@1224|Proteobacteria,2VHU2@28216|Betaproteobacteria,1KJT5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_852812_1	472759.Nhal_3435	3.98e-117	348.0	COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,1RRMX@1236|Gammaproteobacteria,1WXC1@135613|Chromatiales	135613|Chromatiales	G	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site	cbbL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
k59_281111_1	314345.SPV1_11761	4.95e-22	95.5	COG1249@1|root,COG1249@2|Bacteria,1MVVE@1224|Proteobacteria	1224|Proteobacteria	C	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation	sthA	GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019725,GO:0022857,GO:0022890,GO:0034220,GO:0036094,GO:0042592,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0065007,GO:0065008,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363,GO:1902600	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	iECED1_1282.ECED1_4669,iECs_1301.ECs4891,iZ_1308.Z5521	Pyr_redox_2,Pyr_redox_dim
k59_1142688_1	187272.Mlg_0452	2.09e-114	364.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_735822_1	1357272.AVEO02000110_gene3684	2.29e-22	96.7	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,1RU8R@1236|Gammaproteobacteria,1Z70E@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_987120_1	78245.Xaut_2906	4.01e-26	99.8	COG2963@1|root,COG2963@2|Bacteria,1PE1X@1224|Proteobacteria,2V5Q9@28211|Alphaproteobacteria,3F23G@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_987120_2	373903.Hore_04480	1.54e-10	62.8	COG2801@1|root,COG2801@2|Bacteria,1TQQY@1239|Firmicutes,2487W@186801|Clostridia	186801|Clostridia	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
k59_106096_1	1009370.ALO_04983	6.09e-18	85.9	COG0834@1|root,COG0834@2|Bacteria,1TQUG@1239|Firmicutes,4H1US@909932|Negativicutes	909932|Negativicutes	ET	Belongs to the bacterial solute-binding protein 3 family	glnH	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_987132_1	471853.Bcav_1207	5.29e-55	195.0	COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_1867608_1	1120950.KB892812_gene7077	5.39e-12	70.1	COG0488@1|root,COG0488@2|Bacteria,2GKBQ@201174|Actinobacteria,4DNB9@85009|Propionibacteriales	201174|Actinobacteria	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_441828_1	1048339.KB913029_gene4212	5.05e-109	346.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria,4ERV9@85013|Frankiales	201174|Actinobacteria	E	Vitamin B12 dependent methionine synthase activation	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_1867611_1	471853.Bcav_1137	4.67e-71	232.0	COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria	201174|Actinobacteria	I	carboxylase	bccA	-	6.3.4.14,6.4.1.2,6.4.1.3	ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04385	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_1205685_1	794903.OPIT5_04205	1.13e-113	339.0	COG0282@1|root,COG0282@2|Bacteria,46TZF@74201|Verrucomicrobia,3K7U1@414999|Opitutae	414999|Opitutae	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
k59_324693_2	1301098.PKB_5481	2.66e-61	204.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0659 Sulfate permease and related transporters (MFS superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
k59_281140_1	935839.JAGJ01000006_gene3436	3.73e-47	164.0	COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria,4F39D@85017|Promicromonosporaceae	201174|Actinobacteria	G	PFAM ABC transporter related	-	-	3.6.3.17	ko:K10548	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.5	-	-	ABC_tran
k59_928057_1	935567.JAES01000007_gene1860	3.19e-52	179.0	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1T49A@1236|Gammaproteobacteria,1XDC3@135614|Xanthomonadales	135614|Xanthomonadales	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_281159_1	519989.ECTPHS_04990	2.38e-103	320.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1WWE3@135613|Chromatiales	135613|Chromatiales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1096751_2	443143.GM18_3043	4.32e-18	82.0	COG1607@1|root,COG1607@2|Bacteria,1RAEQ@1224|Proteobacteria,42SPA@68525|delta/epsilon subdivisions,2WPPE@28221|Deltaproteobacteria,43VDT@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_1096751_3	352165.HMPREF7215_0847	0.000451	41.2	COG3422@1|root,COG3422@2|Bacteria	2|Bacteria	S	double-strand break repair	trpS	-	6.1.1.2	ko:K01867,ko:K09946	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DUF1508,tRNA-synt_1b
k59_1556643_1	1232437.KL662020_gene785	1.52e-126	379.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2MIPH@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_735866_1	2340.JV46_15090	3.16e-72	229.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,1J4X6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_4393,iECSF_1327.ECSF_4063,iJN746.PP_4889	Adenylsucc_synt
k59_735866_2	572477.Alvin_1229	1.51e-27	110.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1WVUR@135613|Chromatiales	135613|Chromatiales	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
k59_1097227_2	382464.ABSI01000011_gene2976	8.95e-49	159.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_1676232_1	411154.GFO_3033	4.83e-26	107.0	COG1893@1|root,COG1893@2|Bacteria,4NMFF@976|Bacteroidetes,1I3H3@117743|Flavobacteriia	976|Bacteroidetes	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_400393_1	870187.Thini_0399	1.99e-92	281.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,1RMNR@1236|Gammaproteobacteria,4609K@72273|Thiotrichales	72273|Thiotrichales	E	Aminotransferase class-V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_1868390_1	632245.CLP_1785	3.81e-11	68.6	COG1975@1|root,COG1975@2|Bacteria,1UZDB@1239|Firmicutes,25D6N@186801|Clostridia,36U7S@31979|Clostridiaceae	186801|Clostridia	O	XdhC and CoxI family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
k59_1441251_1	1232437.KL661985_gene3581	4.17e-88	271.0	COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,42NSB@68525|delta/epsilon subdivisions,2WIKP@28221|Deltaproteobacteria,2MJ70@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K09970	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
k59_325148_1	251229.Chro_1292	9.4e-27	104.0	COG3124@1|root,COG3124@2|Bacteria,1GKY3@1117|Cyanobacteria,3VMTC@52604|Pleurocapsales	1117|Cyanobacteria	S	Pfam:DUF479	-	-	-	-	-	-	-	-	-	-	-	-	ACP_PD
k59_325148_2	1045856.EcWSU1_01911	1.72e-05	46.6	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1SC2U@1236|Gammaproteobacteria,3X378@547|Enterobacter	1236|Gammaproteobacteria	T	Membrane-associated sensor, integral membrane domain	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,GGDEF,MASE4
k59_400416_2	1123228.AUIH01000055_gene3731	2.87e-46	163.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1XNGN@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_736344_2	768671.ThimaDRAFT_2269	5.32e-82	256.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1WWVW@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM cytochrome c oxidase accessory protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
k59_928827_1	246196.MSMEI_6475	2.73e-127	377.0	COG3385@1|root,COG3385@2|Bacteria,2H68X@201174|Actinobacteria,233KU@1762|Mycobacteriaceae	201174|Actinobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_1868426_1	414684.RC1_1631	6.14e-45	159.0	COG0741@1|root,COG0741@2|Bacteria,1MUMA@1224|Proteobacteria,2TSA5@28211|Alphaproteobacteria,2JSV4@204441|Rhodospirillales	204441|Rhodospirillales	M	transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_1271736_1	768671.ThimaDRAFT_0797	1.19e-86	276.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RN5F@1236|Gammaproteobacteria,1WVWD@135613|Chromatiales	135613|Chromatiales	C	PFAM malic	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
k59_1790444_1	1121438.JNJA01000004_gene853	1.22e-46	152.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,42TPU@68525|delta/epsilon subdivisions,2WQ1M@28221|Deltaproteobacteria,2MC2A@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_1790444_2	96561.Dole_1512	3.01e-59	193.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,42MHR@68525|delta/epsilon subdivisions,2WIY8@28221|Deltaproteobacteria,2MJC5@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1381262_1	1123392.AQWL01000003_gene290	3.09e-109	336.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,1KSG5@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Inorganic H+ pyrophosphatase	-	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_853316_1	404589.Anae109_1788	2.86e-28	115.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,42NJG@68525|delta/epsilon subdivisions,2WJ8R@28221|Deltaproteobacteria,2YZVB@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_281894_1	1121405.dsmv_1838	1.55e-63	215.0	COG0123@1|root,COG0454@1|root,COG0123@2|Bacteria,COG0456@2|Bacteria,1MU7P@1224|Proteobacteria,42NAQ@68525|delta/epsilon subdivisions,2WJPX@28221|Deltaproteobacteria,2MK5E@213118|Desulfobacterales	28221|Deltaproteobacteria	BKQ	Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Hist_deacetyl
k59_106932_1	1430440.MGMSRv2_3922	1.5e-43	154.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2TRUY@28211|Alphaproteobacteria,2JPF8@204441|Rhodospirillales	204441|Rhodospirillales	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
k59_559534_2	1123065.ATWL01000005_gene1208	4.44e-72	232.0	COG3173@1|root,COG3173@2|Bacteria,2I8R6@201174|Actinobacteria	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	mphA	-	-	-	-	-	-	-	-	-	-	-	APH
k59_106933_1	1123261.AXDW01000011_gene563	7.91e-51	171.0	COG0693@1|root,COG0693@2|Bacteria,1MY0C@1224|Proteobacteria,1S3SC@1236|Gammaproteobacteria,1X6IS@135614|Xanthomonadales	135614|Xanthomonadales	S	intracellular protease	pfpI	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
k59_149425_1	1348635.BBJY01000012_gene1113	3.42e-17	83.6	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,1RNH4@1236|Gammaproteobacteria,1XV3J@135623|Vibrionales	135623|Vibrionales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
k59_1868456_1	1216976.AX27061_5491	1.64e-61	202.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHB0@28216|Betaproteobacteria,3T63U@506|Alcaligenaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_149432_1	768671.ThimaDRAFT_1689	2.05e-133	387.0	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales	135613|Chromatiales	P	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
k59_1206163_2	754476.Q7A_1253	2.4e-49	159.0	COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,1S5WU@1236|Gammaproteobacteria,460ZG@72273|Thiotrichales	72273|Thiotrichales	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
k59_1206163_3	187272.Mlg_1508	4.97e-105	307.0	COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,1WY1A@135613|Chromatiales	135613|Chromatiales	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
k59_1733555_1	566466.NOR53_2715	3.24e-55	186.0	COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,1T2D1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0025 NhaP-type Na H and K H antiporters	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger
k59_618199_1	706587.Desti_1562	5.31e-08	53.9	COG1366@1|root,COG1366@2|Bacteria,1NECY@1224|Proteobacteria,431WN@68525|delta/epsilon subdivisions,2WWSD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS
k59_106972_1	765910.MARPU_16605	1.23e-83	262.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WW4B@135613|Chromatiales	135613|Chromatiales	T	response regulator	glnG	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_49208_1	670307.HYPDE_29583	5.78e-06	53.1	COG1216@1|root,COG1216@2|Bacteria,1NK8J@1224|Proteobacteria,2UKYQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_988051_1	159087.Daro_0928	2.29e-34	122.0	COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,2VR2G@28216|Betaproteobacteria,2KWFN@206389|Rhodocyclales	206389|Rhodocyclales	O	Thioredoxin	-	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
k59_1206182_1	765912.Thimo_2552	1.4e-64	206.0	COG0810@1|root,COG0810@2|Bacteria,1R330@1224|Proteobacteria,1RQAX@1236|Gammaproteobacteria,1WWP5@135613|Chromatiales	135613|Chromatiales	M	TIGRFAM TonB	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
k59_325210_1	1089552.KI911559_gene1655	1.45e-84	276.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JRMJ@204441|Rhodospirillales	204441|Rhodospirillales	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_281951_1	1388763.O165_017680	4.16e-36	140.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1YXE7@136845|Pseudomonas putida group	1236|Gammaproteobacteria	NU	General secretion pathway protein	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_736396_1	1255043.TVNIR_1307	4.97e-84	273.0	COG0457@1|root,COG0457@2|Bacteria,1QZTW@1224|Proteobacteria,1T54Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
k59_1206185_1	1279017.AQYJ01000019_gene1464	1.46e-05	45.1	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,1S5V2@1236|Gammaproteobacteria,4679B@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
k59_1206185_2	118797.XP_007457196.1	3.14e-80	246.0	COG0096@1|root,COG0097@1|root,KOG1754@2759|Eukaryota,KOG3254@2759|Eukaryota,39WCS@33154|Opisthokonta	33154|Opisthokonta	J	rRNA binding	MRPL6	GO:0000313,GO:0000315,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005762,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0031974,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0097159,GO:0098798,GO:0140053,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_1097320_1	768671.ThimaDRAFT_1740	1.46e-64	202.0	COG1863@1|root,COG1863@2|Bacteria,1QM1G@1224|Proteobacteria,1SEI8@1236|Gammaproteobacteria,1X25V@135613|Chromatiales	135613|Chromatiales	P	PFAM Na H ion antiporter subunit	-	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
k59_1794502_1	526225.Gobs_0108	6.68e-69	222.0	COG2519@1|root,COG2519@2|Bacteria,2GMKZ@201174|Actinobacteria,4EUG4@85013|Frankiales	201174|Actinobacteria	J	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
k59_154181_1	743721.Psesu_1279	1.02e-95	289.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1X315@135614|Xanthomonadales	135614|Xanthomonadales	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
k59_1794506_1	450851.PHZ_c2009	3.12e-42	155.0	COG1680@1|root,COG1680@2|Bacteria,1MVZN@1224|Proteobacteria,2V9NS@28211|Alphaproteobacteria,2KF0W@204458|Caulobacterales	204458|Caulobacterales	V	PFAM Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
k59_1147273_1	1123320.KB889683_gene2059	9.04e-12	66.6	COG1309@1|root,COG1309@2|Bacteria,2I9IJ@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
k59_622715_1	880072.Desac_0130	1.11e-120	359.0	COG1362@1|root,COG1362@2|Bacteria,1NT1D@1224|Proteobacteria,42MN0@68525|delta/epsilon subdivisions,2WJ7P@28221|Deltaproteobacteria,2MRDA@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM Aminopeptidase I zinc metalloprotease (M18)	apeA	-	3.4.11.21	ko:K01267	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	Peptidase_M18
k59_55525_1	1445613.JALM01000004_gene4561	0.000954	41.6	COG2267@1|root,COG2267@2|Bacteria,2I2GI@201174|Actinobacteria,4E341@85010|Pseudonocardiales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_55525_2	1235457.C404_19745	1.77e-26	99.8	2E6W9@1|root,331FT@2|Bacteria,1N6E1@1224|Proteobacteria,2VVIR@28216|Betaproteobacteria,1K8KB@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3567)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3567
k59_1875359_1	234267.Acid_5024	7.54e-43	159.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
k59_213355_1	1123392.AQWL01000004_gene2601	2.25e-54	196.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,1KSQ4@119069|Hydrogenophilales	119069|Hydrogenophilales	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1739033_1	583355.Caka_1597	2.31e-94	286.0	COG0668@1|root,COG0668@2|Bacteria,46UFI@74201|Verrucomicrobia,3K8BZ@414999|Opitutae	414999|Opitutae	M	mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
k59_1681403_1	511995.CFPG_309	8.39e-70	217.0	COG0566@1|root,COG0566@2|Bacteria,4NM8C@976|Bacteroidetes,2FS50@200643|Bacteroidia	976|Bacteroidetes	J	RNA methyltransferase TrmH family	spoU	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
k59_1348278_1	1231190.NA8A_00740	3.85e-24	102.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2TUKR@28211|Alphaproteobacteria,43H1E@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
k59_1348278_2	211586.SO_0557	2.45e-05	48.9	COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,1RRI8@1236|Gammaproteobacteria,2Q925@267890|Shewanellaceae	1236|Gammaproteobacteria	S	PFAM GumN family protein	ybaP	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
k59_213357_1	768671.ThimaDRAFT_0661	1.65e-107	317.0	COG3900@1|root,COG3900@2|Bacteria,1NXBA@1224|Proteobacteria,1SZCY@1236|Gammaproteobacteria,1X2JW@135613|Chromatiales	135613|Chromatiales	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
k59_1739035_1	1086011.HJ01_02680	5.63e-49	164.0	COG1028@1|root,COG1028@2|Bacteria,4NGQY@976|Bacteroidetes,1HZ7N@117743|Flavobacteriia,2NTZG@237|Flavobacterium	976|Bacteroidetes	IQ	short-chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_1030255_1	1236504.HMPREF2132_04925	5.94e-13	68.2	COG0607@1|root,COG0607@2|Bacteria,4NUPH@976|Bacteroidetes,2FUP0@200643|Bacteroidia	976|Bacteroidetes	P	Rhodanese-like protein	glpE	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_793865_1	1128421.JAGA01000001_gene2434	5.5e-44	162.0	COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,2NNW5@2323|unclassified Bacteria	2|Bacteria	C	synthetase (ADP forming), alpha	yfiQ	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006475,GO:0006807,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0022607,GO:0032459,GO:0032462,GO:0034212,GO:0036211,GO:0043170,GO:0043254,GO:0043412,GO:0043543,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0052858,GO:0061733,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:1901564	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_936497_1	1167006.UWK_01738	2.22e-09	58.5	COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1MUQV@1224|Proteobacteria,43BUD@68525|delta/epsilon subdivisions,2WTMW@28221|Deltaproteobacteria,2MPRT@213118|Desulfobacterales	28221|Deltaproteobacteria	T	LapD/MoxY periplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,LapD_MoxY_N
k59_936497_2	349521.HCH_03939	5.58e-81	248.0	COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,1S3Y1@1236|Gammaproteobacteria,1XJ4Z@135619|Oceanospirillales	135619|Oceanospirillales	S	Bacterial transglutaminase-like cysteine proteinase BTLCP	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C93
k59_1211207_1	1167006.UWK_02082	3.56e-67	216.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,42NI1@68525|delta/epsilon subdivisions,2WK14@28221|Deltaproteobacteria,2MIFC@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_936501_2	936548.HMPREF1136_1701	3.4e-26	116.0	COG1361@1|root,COG1361@2|Bacteria,2I9F2@201174|Actinobacteria,4D3WG@85005|Actinomycetales	201174|Actinobacteria	M	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_56433_1	935839.JAGJ01000001_gene1302	3.04e-86	265.0	COG1609@1|root,COG1609@2|Bacteria,2GJBJ@201174|Actinobacteria,4F5JR@85017|Promicromonosporaceae	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
k59_1348302_1	367299.JOEE01000001_gene1873	5.58e-101	300.0	COG3186@1|root,COG3186@2|Bacteria,2GKCB@201174|Actinobacteria,4FFVJ@85021|Intrasporangiaceae	201174|Actinobacteria	E	Phenylalanine 4-monooxygenase	phhA	-	1.14.16.1	ko:K00500	ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230	-	R01795,R07211	RC00490	ko00000,ko00001,ko01000	-	-	-	Biopterin_H
k59_741940_1	157783.LK03_20665	6.29e-87	277.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	fadH	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
k59_408444_1	1280953.HOC_17254	1.23e-38	139.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,43WKU@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	COG1171 Threonine dehydratase	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_408444_2	1288494.EBAPG3_17700	3.57e-80	244.0	COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,2VQ6X@28216|Betaproteobacteria,37370@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
k59_408444_3	243233.MCA2477	4.5e-76	251.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1XE8M@135618|Methylococcales	135618|Methylococcales	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	DsbC,Thioredox_DsbH
k59_858443_1	909663.KI867150_gene2034	5.39e-107	320.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,42MU6@68525|delta/epsilon subdivisions,2WIJN@28221|Deltaproteobacteria,2MQFE@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_1103163_1	322710.Avin_09260	8.9e-99	299.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Glutamate-1-semialdehyde aminotransferase	hemL	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iUMNK88_1353.UMNK88_158	Aminotran_3
k59_564971_1	1415778.JQMM01000001_gene1965	5.78e-12	67.0	COG0668@1|root,COG0668@2|Bacteria,1N2GE@1224|Proteobacteria,1SBRX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0668 Small-conductance mechanosensitive channel	cmpX	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
k59_1795219_1	1123228.AUIH01000010_gene3993	1.82e-22	99.8	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1XI78@135619|Oceanospirillales	135619|Oceanospirillales	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_936523_1	1123258.AQXZ01000017_gene3794	1.31e-36	138.0	COG0076@1|root,COG0076@2|Bacteria,2GKIH@201174|Actinobacteria,4FWG4@85025|Nocardiaceae	201174|Actinobacteria	E	Belongs to the group II decarboxylase family	-	-	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
k59_936523_2	1298863.AUEP01000001_gene1023	4.88e-80	245.0	arCOG10607@1|root,30Y0T@2|Bacteria,2I8NG@201174|Actinobacteria,4DW1P@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1795225_2	670487.Ocepr_0558	5.59e-28	105.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1348338_1	1120977.JHUX01000008_gene532	5.77e-32	124.0	COG0350@1|root,COG2207@1|root,COG0350@2|Bacteria,COG2207@2|Bacteria,1N2YQ@1224|Proteobacteria,1RPR3@1236|Gammaproteobacteria,3NJBU@468|Moraxellaceae	1236|Gammaproteobacteria	K	6-O-methylguanine DNA methyltransferase, DNA binding domain	ada	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	DNA_binding_1,HTH_18,Methyltransf_1N
k59_408472_1	471853.Bcav_2582	8.19e-92	281.0	COG0614@1|root,COG0614@2|Bacteria,2GKZJ@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Fe3 -hydroxamate transport system, periplasmic component	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
k59_1446440_1	870187.Thini_2323	2.09e-20	93.6	COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,1RQZK@1236|Gammaproteobacteria,460F7@72273|Thiotrichales	72273|Thiotrichales	S	PQQ-dependent catabolism-associated beta-propeller protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
k59_683313_1	1713.JOFV01000002_gene707	5.19e-22	94.7	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
k59_114999_1	1184607.AUCHE_16_01290	4.3e-11	63.5	COG0031@1|root,COG0031@2|Bacteria,2GJGN@201174|Actinobacteria,4F7D7@85018|Dermatophilaceae	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	2.3.1.263	ko:K21400	-	-	-	-	ko00000,ko01000	-	-	-	PALP
k59_114999_2	994573.T472_0217290	1.1e-26	101.0	2E6IF@1|root,3315M@2|Bacteria,1VAX0@1239|Firmicutes,24N55@186801|Clostridia,36KEX@31979|Clostridiaceae	186801|Clostridia	-	-	ortA	GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	2.3.1.263	ko:K21399	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_114999_3	391009.Tmel_0905	8.35e-37	134.0	COG3804@1|root,COG3804@2|Bacteria,2GCFP@200918|Thermotogae	200918|Thermotogae	C	PFAM dihydrodipicolinate reductase	-	-	1.4.1.12,1.4.1.26	ko:K21672	ko00310,ko00330,ko00472,map00310,map00330,map00472	-	R02825,R04200,R04201,R04687,R04688	RC00249,RC00790	ko00000,ko00001,ko01000	-	-	-	DapB_N
k59_330838_1	591157.SSLG_02589	3.2e-79	243.0	COG1670@1|root,COG1670@2|Bacteria,2HAFI@201174|Actinobacteria	201174|Actinobacteria	J	N-acetyltransferase	rimJ	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
k59_115016_1	1121405.dsmv_0150	1.47e-95	286.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,42MP8@68525|delta/epsilon subdivisions,2WKMR@28221|Deltaproteobacteria,2MIXA@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_793916_1	479432.Sros_1271	1.67e-116	345.0	COG4603@1|root,COG4603@2|Bacteria,2GKAZ@201174|Actinobacteria,4EGW6@85012|Streptosporangiales	201174|Actinobacteria	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_565003_1	743718.Isova_0019	6.79e-157	463.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4F3FG@85017|Promicromonosporaceae	201174|Actinobacteria	KLT	Protein kinase domain	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_995866_1	590998.Celf_1266	2.73e-126	374.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,2GK3B@201174|Actinobacteria,4F260@85016|Cellulomonadaceae	201174|Actinobacteria	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	-	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CbiX,NAD_binding_7,TP_methylase
k59_1511932_1	243233.MCA0071	5.55e-43	146.0	COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,1S6FG@1236|Gammaproteobacteria,1XF04@135618|Methylococcales	135618|Methylococcales	S	pfam ammecr1	-	-	-	-	-	-	-	-	-	-	-	-	AMMECR1
k59_1739115_1	1232453.BAIF02000077_gene4912	1.06e-53	182.0	COG0673@1|root,COG0673@2|Bacteria,1TPT5@1239|Firmicutes,248MV@186801|Clostridia	186801|Clostridia	E	Oxidoreductase NAD-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_1681478_1	298655.KI912266_gene5173	1.09e-62	217.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4ERJ2@85013|Frankiales	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_995877_1	1122599.AUGR01000002_gene3664	4.19e-12	69.3	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1XIJ5@135619|Oceanospirillales	135619|Oceanospirillales	O	ATPase with chaperone activity	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_995877_2	1158294.JOMI01000003_gene2472	1.09e-09	58.5	COG0210@1|root,COG0210@2|Bacteria,4NDWN@976|Bacteroidetes,2FNIM@200643|Bacteroidia	976|Bacteroidetes	L	DNA helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_447791_2	395493.BegalDRAFT_0385	2.56e-22	99.0	COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,1RPTU@1236|Gammaproteobacteria,461DX@72273|Thiotrichales	72273|Thiotrichales	I	aromatic hydrocarbon degradation	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_155092_1	572477.Alvin_0868	3.11e-36	127.0	COG0607@1|root,COG0607@2|Bacteria,1RKAQ@1224|Proteobacteria,1SC2Q@1236|Gammaproteobacteria,1X1H4@135613|Chromatiales	135613|Chromatiales	P	Rhodanese-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_213450_1	1049564.TevJSym_aa01810	2.01e-67	224.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J8SM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Citrate transporter	sac1	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_447801_1	1123257.AUFV01000008_gene517	1.15e-29	120.0	COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria	1224|Proteobacteria	M	Capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
k59_995898_1	1203602.HMPREF1527_01323	4.51e-27	115.0	COG0402@1|root,COG0402@2|Bacteria,2GM63@201174|Actinobacteria,4CV60@84998|Coriobacteriia	84998|Coriobacteriia	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1511949_1	1415778.JQMM01000001_gene1272	3.46e-76	234.0	COG4122@1|root,COG4122@2|Bacteria,1N57D@1224|Proteobacteria,1T9XT@1236|Gammaproteobacteria,1J7DV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
k59_683361_1	156889.Mmc1_1582	1.46e-77	243.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2TRMH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
k59_1148068_1	1198452.Jab_1c17280	9.85e-32	127.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2VIK1@28216|Betaproteobacteria,472FY@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Putative peptidoglycan binding domain	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
k59_506490_1	1430440.MGMSRv2_1215	3.89e-53	174.0	COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,2TU8X@28211|Alphaproteobacteria,2JS1G@204441|Rhodospirillales	204441|Rhodospirillales	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_506490_2	713586.KB900536_gene300	2.23e-26	98.2	2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,1SF0T@1236|Gammaproteobacteria,1WZNJ@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
k59_408580_1	1396858.Q666_01075	2.32e-10	61.6	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,464G9@72275|Alteromonadaceae	1236|Gammaproteobacteria	EH	COG0147 Anthranilate para-aminobenzoate synthases component I	pabB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.6.1.85	ko:K01665	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	iEC042_1314.EC042_1977	Anth_synt_I_N,Chorismate_bind
k59_408580_2	1380387.JADM01000010_gene3936	1.81e-112	326.0	COG0560@1|root,COG0560@2|Bacteria,1MZPG@1224|Proteobacteria,1RRRU@1236|Gammaproteobacteria,1XHS1@135619|Oceanospirillales	135619|Oceanospirillales	E	phosphoserine phosphatase	thrH	-	2.7.1.39,3.1.3.3	ko:K02203	ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230	M00018	R00582,R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD,Hydrolase
k59_1562592_1	1049564.TevJSym_av00120	2.78e-18	84.3	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1J4HM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0003674,GO:0003824,GO:0004044,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0034654,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iAF1260.b2312,iB21_1397.B21_02197,iBWG_1329.BWG_2086,iECBD_1354.ECBD_1347,iECB_1328.ECB_02237,iECDH10B_1368.ECDH10B_2474,iECDH1ME8569_1439.ECDH1ME8569_2250,iECD_1391.ECD_02237,iECIAI1_1343.ECIAI1_2389,iECO103_1326.ECO103_2776,iECO111_1330.ECO111_3060,iECO26_1355.ECO26_3300,iECW_1372.ECW_m2501,iEKO11_1354.EKO11_1453,iETEC_1333.ETEC_2448,iEcDH1_1363.EcDH1_1344,iEcE24377_1341.EcE24377A_2606,iEcolC_1368.EcolC_1340,iJO1366.b2312,iJR904.b2312,iSF_1195.SF2388,iSFxv_1172.SFxv_2633,iSSON_1240.SSON_2370,iS_1188.S2523,iSbBS512_1146.SbBS512_E2690,iUMNK88_1353.UMNK88_2863,iWFL_1372.ECW_m2501,iY75_1357.Y75_RS12125	GATase_6,GATase_7,Pribosyltran
k59_1562592_2	566466.NOR53_923	9.86e-20	83.2	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,1S8Z7@1236|Gammaproteobacteria,1J6Q9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
k59_1739149_1	85643.Tmz1t_1202	3.61e-103	323.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,2KV8K@206389|Rhodocyclales	206389|Rhodocyclales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1681507_1	1095769.CAHF01000022_gene225	1.25e-71	228.0	COG3386@1|root,COG3386@2|Bacteria,1MX7V@1224|Proteobacteria,2VN94@28216|Betaproteobacteria,476H6@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Strictosidine synthase	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2,SGL,Str_synth
k59_1876706_1	880072.Desac_0816	6.57e-86	265.0	COG0247@1|root,COG0247@2|Bacteria,1N5Q2@1224|Proteobacteria,42P5D@68525|delta/epsilon subdivisions,2WJ9I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Cysteine-rich	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17
k59_1277787_1	977880.RALTA_A2856	2.23e-69	222.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,1K08M@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
k59_1277787_2	765912.Thimo_1648	3.9e-51	167.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria,1WWVC@135613|Chromatiales	135613|Chromatiales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
k59_1211306_1	1198232.CYCME_0821	7.37e-57	186.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,45ZN2@72273|Thiotrichales	72273|Thiotrichales	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_683387_1	1282876.BAOK01000001_gene1464	2.54e-53	190.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,4BPAA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_56562_1	452637.Oter_2839	1.59e-57	191.0	COG0436@1|root,COG0436@2|Bacteria,46SFZ@74201|Verrucomicrobia,3K7B5@414999|Opitutae	414999|Opitutae	E	aminotransferase class I and II	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_742052_1	641491.DND132_1317	5.98e-13	66.2	COG0640@1|root,COG0640@2|Bacteria,1MZT1@1224|Proteobacteria,42VSP@68525|delta/epsilon subdivisions,2WRGT@28221|Deltaproteobacteria,2MCUX@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	PFAM regulatory protein ArsR	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
k59_1030393_1	1232410.KI421424_gene1677	1.91e-33	120.0	COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria,42W8Z@68525|delta/epsilon subdivisions,2WS5B@28221|Deltaproteobacteria,43V1B@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
k59_1511979_1	631362.Thi970DRAFT_03690	5.37e-110	329.0	COG2863@1|root,COG2863@2|Bacteria,1R5BS@1224|Proteobacteria,1RYHW@1236|Gammaproteobacteria,1WWNB@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_CBB3
k59_1511981_1	1047013.AQSP01000137_gene548	3.93e-75	238.0	COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,2NS55@2323|unclassified Bacteria	2|Bacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD,HD_5,PAS_4,PAS_9,PocR
k59_683393_1	572477.Alvin_2173	2.67e-63	213.0	COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,1WW3V@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA	rlmL	-	2.1.1.173,2.1.1.264	ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
k59_858552_1	522306.CAP2UW1_2698	6.69e-53	177.0	COG4318@1|root,COG4318@2|Bacteria,1MVIY@1224|Proteobacteria,2VRE8@28216|Betaproteobacteria	28216|Betaproteobacteria	S	ParB-like nuclease	-	-	-	-	-	-	-	-	-	-	-	-	ParBc_2
k59_1681529_1	1121405.dsmv_1683	8.87e-197	562.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,43BUE@68525|delta/epsilon subdivisions,2X75I@28221|Deltaproteobacteria,2MPKE@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Conserved carboxylase domain	oadA	-	2.1.3.1,4.1.1.3,6.4.1.1	ko:K01571,ko:K01960,ko:K03416	ko00020,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00640,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344,R00353,R00930	RC00040,RC00097,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_1386808_1	335543.Sfum_0155	2.62e-88	266.0	COG1774@1|root,COG1774@2|Bacteria,1MZBX@1224|Proteobacteria,42NE3@68525|delta/epsilon subdivisions,2WK98@28221|Deltaproteobacteria,2MQEI@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PSP1 C-terminal conserved region	-	-	-	-	-	-	-	-	-	-	-	-	PSP1
k59_1511987_1	1169161.KB897716_gene5844	1.88e-29	113.0	COG0785@1|root,COG0785@2|Bacteria,2IMP9@201174|Actinobacteria	201174|Actinobacteria	O	Cytochrome C biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_748318_1	1123399.AQVE01000001_gene733	6.79e-100	296.0	COG0627@1|root,COG0627@2|Bacteria,1MUID@1224|Proteobacteria,1RMR3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Serine hydrolase involved in the detoxification of formaldehyde	fghA	-	3.1.2.12	ko:K01070	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R00527	RC00167,RC00320	ko00000,ko00001,ko01000	-	CE1	-	Esterase
k59_1688174_1	998674.ATTE01000001_gene2757	2.43e-59	201.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,45ZYF@72273|Thiotrichales	72273|Thiotrichales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_337626_2	278963.ATWD01000001_gene4163	3.11e-08	54.3	COG0148@1|root,COG0148@2|Bacteria,3Y2IT@57723|Acidobacteria,2JI6Q@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_1393030_1	631362.Thi970DRAFT_03881	7.81e-33	124.0	COG1704@1|root,COG1704@2|Bacteria,1RDUH@1224|Proteobacteria,1S2KR@1236|Gammaproteobacteria,1WY4K@135613|Chromatiales	135613|Chromatiales	S	E3 Ubiquitin ligase	-	-	-	-	-	-	-	-	-	-	-	-	GIDE
k59_571304_1	396588.Tgr7_1014	3.95e-75	250.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,1WW9S@135613|Chromatiales	135613|Chromatiales	E	Bacterial transglutaminase-like N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
k59_454126_1	1049564.TevJSym_aw00060	4.54e-33	129.0	28KIA@1|root,2ZA3I@2|Bacteria,1MXIF@1224|Proteobacteria,1RMA6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	dsrS	-	-	-	-	-	-	-	-	-	-	-	-
k59_1037291_1	706587.Desti_2876	4.17e-61	207.0	COG4995@1|root,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,FGE-sulfatase,NB-ARC,TPR_1,TPR_16,TPR_2,TPR_8
k59_630290_1	1463917.JODC01000011_gene4597	2.05e-106	329.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria	201174|Actinobacteria	G	hydrolase, family 3	bgl2	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_571312_1	56780.SYN_01456	8.76e-38	137.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42NC3@68525|delta/epsilon subdivisions,2WIJJ@28221|Deltaproteobacteria,2MQ4K@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_571312_2	56780.SYN_01457	8.64e-12	65.1	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42P7V@68525|delta/epsilon subdivisions,2WJQA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM ABC-2 type transporter	ybhS	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
k59_865341_1	1121472.AQWN01000008_gene1913	1.78e-13	77.8	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,26166@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Pyr_redox_2
k59_865341_2	1265505.ATUG01000003_gene822	4.89e-18	78.2	COG2204@1|root,COG2204@2|Bacteria,1RHQV@1224|Proteobacteria,42T2A@68525|delta/epsilon subdivisions,2WPA0@28221|Deltaproteobacteria,2MKC4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_337643_1	335543.Sfum_1278	2.87e-97	302.0	COG0427@1|root,COG0454@1|root,COG0427@2|Bacteria,COG0456@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MR2F@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	acetyl-CoA	-	-	-	ko:K18122,ko:K18288	ko00650,ko00660,ko01100,ko01200,map00650,map00660,map01100,map01200	-	R02407,R05336,R10600	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2142,iAF987.Gmet_3304	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1,Acetyltransf_3
k59_454139_1	1151116.Q7S_14700	2.45e-50	181.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,1RN57@1236|Gammaproteobacteria,3FGN9@34037|Rahnella	1236|Gammaproteobacteria	E	ABC-type oligopeptide transport system, periplasmic component	oppA3	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
k59_219590_1	522306.CAP2UW1_3130	4.5e-32	128.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,2VZWB@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
k59_1627138_1	768671.ThimaDRAFT_1461	2.42e-80	244.0	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,1RRT6@1236|Gammaproteobacteria,1WXWX@135613|Chromatiales	135613|Chromatiales	K	response regulator receiver	-	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1217961_1	1123319.AUBE01000015_gene5689	7.8e-55	192.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX2	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_1453283_1	3983.cassava4.1_000718m	9.54e-43	159.0	COG1003@1|root,KOG2040@2759|Eukaryota,37JTX@33090|Viridiplantae,3GEI5@35493|Streptophyta,4JMMM@91835|fabids	35493|Streptophyta	E	The glycine cleavage system catalyzes the degradation of glycine	-	GO:0000166,GO:0001505,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009507,GO:0009526,GO:0009532,GO:0009534,GO:0009536,GO:0009570,GO:0009579,GO:0009941,GO:0009987,GO:0010035,GO:0010038,GO:0016054,GO:0017076,GO:0017144,GO:0019752,GO:0030554,GO:0031967,GO:0031975,GO:0031976,GO:0031984,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042133,GO:0042135,GO:0042221,GO:0042737,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046686,GO:0048046,GO:0050896,GO:0065007,GO:0065008,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.4.2	ko:K00281	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
k59_571344_1	156889.Mmc1_3637	0.000248	46.6	COG5421@1|root,COG5421@2|Bacteria,1R6MI@1224|Proteobacteria,2UCZG@28211|Alphaproteobacteria	1224|Proteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1037340_1	768671.ThimaDRAFT_0869	1.33e-55	184.0	COG1463@1|root,COG1463@2|Bacteria,1MYEF@1224|Proteobacteria,1S8EQ@1236|Gammaproteobacteria,1WYKW@135613|Chromatiales	135613|Chromatiales	Q	MlaD protein	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_1037340_2	768671.ThimaDRAFT_0868	2.72e-34	124.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1S1PR@1236|Gammaproteobacteria,1WY6G@135613|Chromatiales	135613|Chromatiales	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_630337_1	765911.Thivi_4219	4.88e-24	92.0	COG1841@1|root,COG1841@2|Bacteria,1N6ZE@1224|Proteobacteria,1SC8N@1236|Gammaproteobacteria,1WZ8N@135613|Chromatiales	135613|Chromatiales	J	Ribosomal protein L30	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
k59_630337_2	637905.SVI_4143	3.84e-55	176.0	COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,1S3P6@1236|Gammaproteobacteria,2QBMD@267890|Shewanellaceae	1236|Gammaproteobacteria	J	binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
k59_630337_3	2340.JV46_07170	1.19e-75	239.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1J5AU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_1153832_1	471853.Bcav_4032	6.7e-65	221.0	COG0392@1|root,COG0392@2|Bacteria,2GMAV@201174|Actinobacteria	201174|Actinobacteria	T	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
k59_454179_1	1031711.RSPO_c00998	2.01e-65	212.0	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2VH6N@28216|Betaproteobacteria,1K1GJ@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
k59_1153835_1	794903.OPIT5_01265	1.03e-11	66.6	COG3547@1|root,COG3547@2|Bacteria,46WNP@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1627183_1	335543.Sfum_2658	9.2e-66	218.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,PAS,PAS_3,PAS_9,Response_reg
k59_1110953_1	1049564.TevJSym_ag00400	8.56e-93	280.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1J4GF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_0421	Glycos_trans_3N,Glycos_transf_3
k59_337699_1	1123393.KB891316_gene1328	2e-67	214.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VIK8@28216|Betaproteobacteria,1KRDA@119069|Hydrogenophilales	119069|Hydrogenophilales	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_1569055_1	243233.MCA1475	1.31e-51	183.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1XEQR@135618|Methylococcales	135618|Methylococcales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_1688259_1	1305735.JAFT01000005_gene501	2.4e-27	112.0	COG0697@1|root,COG0697@2|Bacteria,1R3W3@1224|Proteobacteria,2TS0I@28211|Alphaproteobacteria,2PE8F@252301|Oceanicola	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1153843_1	28258.KP05_13465	8.03e-59	191.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,1XHJ7@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
k59_1153843_2	323097.Nham_3142	1.06e-36	136.0	COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,2TSNS@28211|Alphaproteobacteria,3JS52@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Belongs to the protein N5-glutamine methyltransferase family	prmB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.298	ko:K07320	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03009	-	-	-	MTS
k59_571370_1	1397528.Q671_02415	2.61e-40	142.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RN4D@1236|Gammaproteobacteria,1XHWM@135619|Oceanospirillales	135619|Oceanospirillales	S	Dehydrogenase	-	-	-	ko:K12957,ko:K13979	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_571370_2	1129794.C427_4319	3.82e-05	43.9	2DSX7@1|root,33HSU@2|Bacteria,1NGYV@1224|Proteobacteria,1SRWB@1236|Gammaproteobacteria,46BSD@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_454198_1	1123502.AQXD01000003_gene1394	3.13e-06	47.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,1S8VH@1236|Gammaproteobacteria,1X7FC@135614|Xanthomonadales	135614|Xanthomonadales	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_454198_2	713587.THITH_13420	1.11e-47	171.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_630366_1	1502852.FG94_02195	4.21e-53	189.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,472RR@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	PFAM EAL domain, GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GGDEF,PAS_4,PAS_9
k59_512993_2	637905.SVI_2999	3.2e-114	336.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,1RNSW@1236|Gammaproteobacteria,2QATH@267890|Shewanellaceae	1236|Gammaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004486,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0055114,GO:0071704,GO:1901360,GO:1901564	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	iSDY_1059.SDY_0281	THF_DHG_CYH,THF_DHG_CYH_C
k59_865437_1	1121937.AUHJ01000004_gene1013	6.37e-84	265.0	COG2801@1|root,COG2801@2|Bacteria,1MXKK@1224|Proteobacteria,1T7KM@1236|Gammaproteobacteria,46C37@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	PFAM Integrase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_571385_1	644282.Deba_1164	1.72e-24	109.0	COG3523@1|root,COG3523@2|Bacteria,1NRHK@1224|Proteobacteria,42Z87@68525|delta/epsilon subdivisions,2WTYM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1218026_1	767434.Fraau_0159	7.67e-93	298.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1X31Q@135614|Xanthomonadales	135614|Xanthomonadales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_1688282_1	1380394.JADL01000014_gene246	5.19e-62	201.0	COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,2TZ7M@28211|Alphaproteobacteria,2JXKC@204441|Rhodospirillales	204441|Rhodospirillales	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_454217_2	1379281.AVAG01000041_gene859	4.3e-08	54.7	2DTNR@1|root,33M3I@2|Bacteria,1NQ8Z@1224|Proteobacteria,42Y11@68525|delta/epsilon subdivisions,2WT77@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_630384_1	338969.Rfer_1850	5.17e-78	261.0	2D125@1|root,32T9R@2|Bacteria,1N30F@1224|Proteobacteria,2VX2H@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_571396_1	983328.AFGH01000030_gene545	7.48e-08	51.2	COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,42SHZ@68525|delta/epsilon subdivisions,2YPDZ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
k59_571396_2	105559.Nwat_2179	1.98e-35	126.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1WXDE@135613|Chromatiales	135613|Chromatiales	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_1747227_1	1454010.JEOE01000011_gene2396	7.52e-35	137.0	COG4425@1|root,COG4425@2|Bacteria,2IBWT@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta-hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_9,Abhydrolase_9_N
k59_221017_2	926550.CLDAP_10820	1.85e-05	51.6	COG3187@1|root,COG3187@2|Bacteria	2|Bacteria	O	response to heat	-	-	-	ko:K03668	-	-	-	-	ko00000	-	-	-	Lipoprotein_21,META,YscW
k59_799891_1	472759.Nhal_0208	5.64e-89	276.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1WVVC@135613|Chromatiales	135613|Chromatiales	F	TIGRFAM dihydroorotase, multifunctional complex type	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_1521367_1	367299.JOEE01000001_gene1717	7e-86	258.0	COG0576@1|root,COG0576@2|Bacteria,2GP4F@201174|Actinobacteria,4FH8C@85021|Intrasporangiaceae	201174|Actinobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_749840_1	745310.G432_10965	3.77e-32	120.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,2TSD6@28211|Alphaproteobacteria,2K19B@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
k59_749840_2	1485544.JQKP01000002_gene1552	4.89e-08	55.5	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2VSPK@28216|Betaproteobacteria,44VV3@713636|Nitrosomonadales	28216|Betaproteobacteria	S	PFAM Phosphoribosyltransferase	comF	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
k59_1628696_1	1108045.GORHZ_135_00300	2.67e-37	143.0	COG1894@1|root,COG1894@2|Bacteria,2GNN9@201174|Actinobacteria,4GF2Q@85026|Gordoniaceae	201174|Actinobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_1287292_1	1116472.MGMO_168c00050	1.18e-38	131.0	COG5304@1|root,COG5304@2|Bacteria,1N269@1224|Proteobacteria,1SAZ0@1236|Gammaproteobacteria,1XGGH@135618|Methylococcales	135618|Methylococcales	S	CopG antitoxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	CopG_antitoxin
k59_339091_1	1123257.AUFV01000013_gene2779	4.66e-154	442.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria,1X7SD@135614|Xanthomonadales	135614|Xanthomonadales	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_690884_1	1449350.OCH239_04425	7.92e-73	234.0	COG0500@1|root,COG2890@1|root,COG2226@2|Bacteria,COG2890@2|Bacteria,1R5JA@1224|Proteobacteria,2TXTJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
k59_690885_1	742766.HMPREF9455_00631	5.94e-72	230.0	COG2710@1|root,COG2710@2|Bacteria,4NIUV@976|Bacteroidetes,2FPZJ@200643|Bacteroidia,22ZYV@171551|Porphyromonadaceae	976|Bacteroidetes	C	Nitrogenase component 1 type Oxidoreductase	-	-	-	ko:K02587	-	-	-	-	ko00000	-	-	-	Oxidored_nitro
k59_1454869_1	367299.JOEE01000007_gene131	1.52e-208	592.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria,4FF74@85021|Intrasporangiaceae	201174|Actinobacteria	O	Thioredoxin reductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
k59_1112546_1	713587.THITH_15155	8.83e-74	244.0	COG3547@1|root,COG3547@2|Bacteria,1NN5F@1224|Proteobacteria	1224|Proteobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_690897_1	1249627.D779_0418	1.8e-65	204.0	COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1WWJB@135613|Chromatiales	135613|Chromatiales	E	PFAM Amino acid-binding ACT	-	-	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT_6
k59_1454878_1	479434.Sthe_2682	3.27e-33	130.0	COG2265@1|root,COG2265@2|Bacteria,2G6IV@200795|Chloroflexi,27XG5@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_1747266_1	273063.STK_04990	2.53e-32	126.0	COG2048@1|root,arCOG00338@2157|Archaea,2XRI5@28889|Crenarchaeota	28889|Crenarchaeota	C	Succinate dehydrogenase subunit	sdhC	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00241,ko:K03389	ko00020,ko00190,ko00650,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00356,M00357,M00374,M00376,M00563,M00567	R02164,R04540,R11928,R11931,R11943,R11944	RC00011,RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_1521408_1	1713.JOFV01000012_gene815	6.75e-66	215.0	COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4F0SQ@85016|Cellulomonadaceae	201174|Actinobacteria	EG	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_867120_1	522306.CAP2UW1_1994	2.29e-19	89.4	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,2VK56@28216|Betaproteobacteria,1KQI0@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	CP	Domain related to MnhB subunit of Na+/H+ antiporter	-	-	-	ko:K05559	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
k59_221076_1	991905.SL003B_0988	3.43e-125	369.0	COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2TSJV@28211|Alphaproteobacteria,4BSN9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Ribulose bisphosphate carboxylase large chain, catalytic domain	cbbL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
k59_1287331_1	1121939.L861_23200	4.05e-27	112.0	COG3713@1|root,COG3713@2|Bacteria,1RB2A@1224|Proteobacteria,1S3K6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	MltA-interacting protein MipA	-	-	-	ko:K07274	-	-	-	-	ko00000,ko02000	9.B.99.1	-	-	MipA
k59_1287331_2	631362.Thi970DRAFT_04429	1.16e-130	407.0	COG3264@1|root,COG4942@1|root,COG3264@2|Bacteria,COG4942@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1X0ES@135613|Chromatiales	135613|Chromatiales	DM	PFAM Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,MscS_TM,MscS_porin
k59_749892_1	457421.CBFG_02608	9.36e-11	63.2	COG0352@1|root,COG0352@2|Bacteria,1V3ZR@1239|Firmicutes,24DG3@186801|Clostridia,269AV@186813|unclassified Clostridiales	186801|Clostridia	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
k59_749892_2	765914.ThisiDRAFT_0508	3.2e-77	239.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,1RNFP@1236|Gammaproteobacteria,1WXAI@135613|Chromatiales	135613|Chromatiales	H	Phosphomethylpyrimidine kinase	-	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
k59_572617_1	1288298.rosmuc_01643	5.66e-72	229.0	COG3660@1|root,COG3660@2|Bacteria,1R70U@1224|Proteobacteria,2TQWV@28211|Alphaproteobacteria,46PPH@74030|Roseovarius	28211|Alphaproteobacteria	M	Mitochondrial fission ELM1	-	-	-	ko:K07276	-	-	-	-	ko00000	-	-	-	Mito_fiss_Elm1
k59_690931_2	1279017.AQYJ01000026_gene58	1.31e-52	186.0	COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,1SEWA@1236|Gammaproteobacteria,469S7@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
k59_162918_1	460265.Mnod_4088	1.19e-19	92.8	COG5519@1|root,COG5519@2|Bacteria,1MW5H@1224|Proteobacteria,2TUDP@28211|Alphaproteobacteria,1JU8D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Domain of unknown function (DUF927)	-	-	-	ko:K06919	-	-	-	-	ko00000	-	-	-	DUF927,Toprim_3
k59_631661_1	497964.CfE428DRAFT_1142	1.91e-81	257.0	COG1502@1|root,COG1502@2|Bacteria,46U9X@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_1219592_1	754477.Q7C_631	1.55e-41	144.0	COG2888@1|root,COG2888@2|Bacteria,1P9T7@1224|Proteobacteria,1RYIB@1236|Gammaproteobacteria,460Y8@72273|Thiotrichales	72273|Thiotrichales	J	Zinc-ribbon containing domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1451
k59_631664_1	1122201.AUAZ01000010_gene2547	6.3e-69	217.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,465W7@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Di-haem cytochrome c peroxidase	ccp	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
k59_867160_1	765910.MARPU_15120	1.55e-45	160.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1WW6N@135613|Chromatiales	135613|Chromatiales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_867170_1	859657.RPSI07_3081	1.77e-45	149.0	COG3411@1|root,COG3411@2|Bacteria,1MZR4@1224|Proteobacteria,2VTY1@28216|Betaproteobacteria,1K7RZ@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Ferredoxin	fdx	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
k59_229499_2	713586.KB900536_gene2411	7.86e-49	157.0	COG3288@1|root,COG3288@2|Bacteria,1N0TD@1224|Proteobacteria,1SA8D@1236|Gammaproteobacteria,1X1J6@135613|Chromatiales	135613|Chromatiales	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
k59_229499_3	545276.KB898727_gene380	1.28e-36	135.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_1698673_1	768671.ThimaDRAFT_1848	1.84e-96	288.0	COG0639@1|root,COG0639@2|Bacteria,1MXN9@1224|Proteobacteria,1RYPF@1236|Gammaproteobacteria,1WXJ5@135613|Chromatiales	135613|Chromatiales	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
k59_1228417_1	420324.KI911970_gene1552	1.84e-52	172.0	COG3485@1|root,COG3485@2|Bacteria,1MV6K@1224|Proteobacteria,2TUS4@28211|Alphaproteobacteria,1JV2G@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	Dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Dioxygenase_C
k59_698688_1	1341646.CBMO010000059_gene1667	3.58e-31	123.0	COG1002@1|root,COG1002@2|Bacteria,2GN30@201174|Actinobacteria,238GD@1762|Mycobacteriaceae	201174|Actinobacteria	V	Type II restriction enzyme, methylase subunits	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
k59_1228418_1	861299.J421_4375	9.23e-35	127.0	COG1595@1|root,COG1595@2|Bacteria,1ZTNR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1228426_1	1249627.D779_4168	1.19e-86	266.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,1WXR0@135613|Chromatiales	135613|Chromatiales	G	Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides	nagZ	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
k59_638609_1	765911.Thivi_2472	3.09e-100	316.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1WX68@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_806669_1	1338011.BD94_3471	6.3e-08	59.7	COG2244@1|root,COG2244@2|Bacteria,4NDZ0@976|Bacteroidetes,1HWQF@117743|Flavobacteriia,34QZA@308865|Elizabethkingia	976|Bacteroidetes	S	Polysaccharide biosynthesis protein	cap	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
k59_171657_1	1300345.LF41_2820	2.87e-45	153.0	2AQI0@1|root,31FQP@2|Bacteria,1RI31@1224|Proteobacteria,1S4IS@1236|Gammaproteobacteria,1X71C@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_806679_1	316056.RPC_2252	1.03e-62	210.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQU2@28211|Alphaproteobacteria,3JST9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	aidB	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
k59_1162324_1	1537994.JQFW01000031_gene965	8.51e-67	219.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,46444@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_1403525_1	590998.Celf_2952	1.95e-97	288.0	COG0225@1|root,COG0225@2|Bacteria,2GJ1S@201174|Actinobacteria,4F10F@85016|Cellulomonadaceae	201174|Actinobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_876766_1	1049564.TevJSym_aq00100	2.5e-94	283.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,1J50F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	glycyl-tRNA synthetase, alpha subunit	glyQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF1260.b3560,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360	tRNA-synt_2e
k59_1049838_1	622637.KE124774_gene4068	7.32e-35	132.0	COG0845@1|root,COG0845@2|Bacteria,1QN99@1224|Proteobacteria,2U1UD@28211|Alphaproteobacteria,36ZMF@31993|Methylocystaceae	28211|Alphaproteobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_1698714_1	323261.Noc_2109	1.5e-126	390.0	COG0508@1|root,COG1249@1|root,COG0508@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1WWGK@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding,Pyr_redox_2,Pyr_redox_dim
k59_229551_1	105559.Nwat_2653	2.19e-46	157.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,1RS0S@1236|Gammaproteobacteria,1WWNN@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine	-	-	2.4.2.28,2.4.2.44	ko:K00772,ko:K19696	ko00270,ko01100,map00270,map01100	M00034	R01402,R09668	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
k59_229551_2	1049564.TevJSym_ad01570	2.61e-10	63.9	2EC19@1|root,3360G@2|Bacteria,1PBYU@1224|Proteobacteria,1SD34@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Peptidoglycan-binding protein, CsiV	-	-	-	-	-	-	-	-	-	-	-	-	CsiV
k59_876789_1	1122194.AUHU01000002_gene2747	1.37e-16	84.7	COG2198@1|root,COG2198@2|Bacteria,1QY43@1224|Proteobacteria,1S0ZB@1236|Gammaproteobacteria,4641V@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Histidine kinase	fimL	-	-	-	-	-	-	-	-	-	-	-	Hpt
k59_700062_1	1177154.Y5S_02930	1.1e-83	256.0	COG2066@1|root,COG2066@2|Bacteria,1MWB5@1224|Proteobacteria,1RMY9@1236|Gammaproteobacteria,1XHZG@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the glutaminase family	glsA	-	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Glutaminase
k59_1810499_1	1267005.KB911261_gene2308	7.7e-117	358.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2TSZ9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,Transketolase_N
k59_348261_1	471881.PROPEN_02927	1.55e-19	84.3	COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,3Z1TQ@583|Proteus	1236|Gammaproteobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
k59_348261_2	314282.PCNPT3_07320	1.25e-37	129.0	COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,1S5WU@1236|Gammaproteobacteria,2QI75@267894|Psychromonadaceae	1236|Gammaproteobacteria	L	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	ybaB	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:1901363	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
k59_1810504_1	469383.Cwoe_2715	5.85e-45	160.0	COG0038@1|root,COG0038@2|Bacteria,2GJHP@201174|Actinobacteria,4CSKW@84995|Rubrobacteria	84995|Rubrobacteria	P	Voltage gated chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
k59_1051871_1	1380387.JADM01000035_gene1727	2.18e-32	115.0	COG2963@1|root,COG2963@2|Bacteria,1N8W3@1224|Proteobacteria,1SEAC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1051871_2	1313421.JHBV01000055_gene496	2.37e-15	75.9	COG2801@1|root,COG2801@2|Bacteria,4NI49@976|Bacteroidetes,1IY9E@117747|Sphingobacteriia	976|Bacteroidetes	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve,rve_3
k59_760104_1	1173020.Cha6605_2829	1.35e-62	216.0	COG0001@1|root,COG0236@1|root,COG1020@1|root,COG3321@1|root,COG0001@2|Bacteria,COG0236@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1G25N@1117|Cyanobacteria	1117|Cyanobacteria	HQ	Acyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Aminotran_3,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
k59_520679_1	1385518.N798_08810	3.14e-22	88.2	COG0695@1|root,COG0695@2|Bacteria,2IQF9@201174|Actinobacteria,4FHU0@85021|Intrasporangiaceae	201174|Actinobacteria	O	Glutaredoxin	-	-	1.20.4.3	ko:K18917	-	-	-	-	ko00000,ko01000	-	-	-	Glutaredoxin
k59_230953_1	1089455.MOPEL_078_00800	1.27e-116	354.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4F607@85018|Dermatophilaceae	201174|Actinobacteria	C	Fumarate reductase flavoprotein C-term	sdhA	-	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_173118_1	301.JNHE01000006_gene1198	2.86e-13	68.2	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,1YD38@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	F	Belongs to the RimK family	rimK	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
k59_173118_2	317025.Tcr_2062	1.73e-50	171.0	COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,45ZS4@72273|Thiotrichales	72273|Thiotrichales	S	Succinylglutamate desuccinylase aspartoacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
k59_1638704_1	520709.F985_02681	7.31e-36	134.0	COG0753@1|root,COG0753@2|Bacteria,1N4WM@1224|Proteobacteria,1T1QK@1236|Gammaproteobacteria,3NJ16@468|Moraxellaceae	1236|Gammaproteobacteria	P	Catalase	-	-	-	-	-	-	-	-	-	-	-	-	Catalase
k59_1638704_2	1538295.JY96_07525	1.23e-14	77.8	COG3386@1|root,COG3386@2|Bacteria,1MX7V@1224|Proteobacteria,2VN94@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Strictosidine synthase	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2,SGL,Str_synth
k59_1464001_2	1304883.KI912532_gene1531	2.25e-58	194.0	COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2VJ5X@28216|Betaproteobacteria,2KURY@206389|Rhodocyclales	206389|Rhodocyclales	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
k59_1229959_1	178306.PAE2499	5.66e-07	56.2	COG0135@1|root,arCOG01983@2157|Archaea,2XRGR@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
k59_1229959_2	1449126.JQKL01000014_gene2975	1.89e-09	58.2	COG0134@1|root,COG0134@2|Bacteria,1TR94@1239|Firmicutes,249ZY@186801|Clostridia,268Z9@186813|unclassified Clostridiales	186801|Clostridia	E	Indole-3-glycerol phosphate synthase	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
k59_700088_2	1453501.JELR01000001_gene1847	7.23e-60	197.0	COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,1RYFC@1236|Gammaproteobacteria,4666X@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	HPP family	-	-	-	ko:K07168	-	-	-	-	ko00000	-	-	-	HPP
k59_348281_1	1411685.U062_02333	1.38e-05	46.2	COG4341@1|root,COG4341@2|Bacteria,1QHQD@1224|Proteobacteria,1S2ZI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD
k59_348281_2	987059.RBXJA2T_08555	3.81e-50	171.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2VI90@28216|Betaproteobacteria,1KK6J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Iron-containing alcohol dehydrogenase	gbd1	-	1.1.1.61,1.3.1.32	ko:K00043,ko:K00217	ko00361,ko00362,ko00364,ko00623,ko00650,ko01100,ko01120,ko01200,ko01220,map00361,map00362,map00364,map00623,map00650,map01100,map01120,map01200,map01220	-	R01644,R02988,R02989,R05355,R06848,R07781,R09137,R09138,R09223,R09224	RC00087,RC00107,RC01335,RC01689,RC02442	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
k59_700092_1	1120949.KB903301_gene6393	3.27e-95	287.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria,4DB8J@85008|Micromonosporales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
k59_1755689_1	713586.KB900536_gene1663	1.08e-20	87.8	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1RMIZ@1236|Gammaproteobacteria,1WX4R@135613|Chromatiales	135613|Chromatiales	K	PFAM Cyclic nucleotide-binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	Crp,HTH_Crp_2,cNMP_binding
k59_1755689_2	1235457.C404_19010	2.46e-48	161.0	COG2941@1|root,COG2941@2|Bacteria,1RAA1@1224|Proteobacteria,2VQRE@28216|Betaproteobacteria,1K1RC@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol	coq7	-	-	ko:K06134	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00128	R04984,R08775	RC01254	ko00000,ko00001,ko00002,ko01000	-	-	-	COQ7
k59_878435_1	4558.Sb0351s002020.1	5.23e-06	45.1	2EM9F@1|root,2SQZI@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1164106_1	999419.HMPREF1077_01685	2.8e-53	189.0	COG3250@1|root,COG3250@2|Bacteria,4NEP8@976|Bacteroidetes,2FMRW@200643|Bacteroidia,22X6P@171551|Porphyromonadaceae	976|Bacteroidetes	G	Glycosyl hydrolases family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_1700222_1	593907.Celgi_1952	1.19e-90	274.0	COG0548@1|root,COG0548@2|Bacteria,2GKDS@201174|Actinobacteria,4F0UJ@85016|Cellulomonadaceae	201174|Actinobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_1581472_1	1120941.AUBL01000045_gene246	2.28e-39	148.0	COG3021@1|root,COG3021@2|Bacteria,2I9FS@201174|Actinobacteria,4D4BJ@85005|Actinomycetales	201174|Actinobacteria	S	Endonuclease exonuclease phosphatase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_230984_1	697282.Mettu_0283	2.64e-89	280.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1XEDM@135618|Methylococcales	135618|Methylococcales	C	Aconitase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aconitase,Aconitase_C
k59_1755702_1	666681.M301_2570	6.51e-20	89.0	COG1418@1|root,COG1418@2|Bacteria,1RH6M@1224|Proteobacteria,2VRKW@28216|Betaproteobacteria,2KPB8@206350|Nitrosomonadales	206350|Nitrosomonadales	S	mRNA catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_464039_1	1304885.AUEY01000013_gene3130	2.69e-68	220.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,42MJT@68525|delta/epsilon subdivisions,2WJ7W@28221|Deltaproteobacteria,2MHNI@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_1164150_1	795797.C497_05017	3.68e-39	154.0	COG1574@1|root,arCOG00691@2157|Archaea,2XUUZ@28890|Euryarchaeota,23SFX@183963|Halobacteria	183963|Halobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1581499_1	247634.GPB2148_3562	1.44e-109	327.0	COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	alanine symporter	dagA	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_639972_1	479433.Caci_1550	5.19e-48	162.0	COG3467@1|root,COG3467@2|Bacteria,2GJ76@201174|Actinobacteria	201174|Actinobacteria	J	Flavin-nucleotide-binding protein	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
k59_1581502_1	472759.Nhal_3275	7.36e-78	252.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWQV@135613|Chromatiales	135613|Chromatiales	L	it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction	rep	-	3.6.4.12	ko:K03656	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_700149_1	396588.Tgr7_0836	1.55e-116	347.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales	135613|Chromatiales	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
k59_1230044_1	316067.Geob_1122	7.17e-77	242.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42MHH@68525|delta/epsilon subdivisions,2WIMW@28221|Deltaproteobacteria,43RZ9@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iAF987.Gmet_0204	Aminotran_3
k59_231052_1	1453501.JELR01000002_gene1248	3.59e-16	80.1	COG1525@1|root,COG1525@2|Bacteria,1RKRQ@1224|Proteobacteria,1S7UH@1236|Gammaproteobacteria,467WT@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Staphylococcal nuclease homologues	-	-	-	-	-	-	-	-	-	-	-	-	SNase
k59_231052_2	1122169.AREN01000052_gene221	5.84e-31	110.0	COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,1SCMH@1236|Gammaproteobacteria,1JF2H@118969|Legionellales	118969|Legionellales	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
k59_1638797_1	472759.Nhal_3749	2.43e-43	152.0	COG2253@1|root,COG2253@2|Bacteria,1NJT9@1224|Proteobacteria,1S0YI@1236|Gammaproteobacteria,1WXVW@135613|Chromatiales	135613|Chromatiales	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
k59_348368_1	1047013.AQSP01000133_gene2158	1.64e-64	207.0	COG1475@1|root,COG1475@2|Bacteria,2NP7S@2323|unclassified Bacteria	2|Bacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_348382_1	565045.NOR51B_1064	1.58e-24	99.0	COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,1S9Z9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	cytochrome c5	cyc	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	Cytochrome_CBB3
k59_348382_2	313628.LNTAR_09976	4.13e-14	73.2	COG0606@1|root,COG0606@2|Bacteria	2|Bacteria	O	chelatase, subunit chli	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_807897_1	196627.cg2467	6.77e-34	125.0	COG1101@1|root,COG1101@2|Bacteria,2GNP6@201174|Actinobacteria,22KV9@1653|Corynebacteriaceae	201174|Actinobacteria	S	ABC transporter, ATP-binding protein	-	-	-	ko:K05833	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
k59_807897_2	1304880.JAGB01000001_gene329	4.11e-55	183.0	COG4120@1|root,COG4120@2|Bacteria,1TPDJ@1239|Firmicutes,249P1@186801|Clostridia	186801|Clostridia	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K05832	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	BPD_transp_2
k59_173240_1	768671.ThimaDRAFT_2971	2.95e-78	243.0	COG0850@1|root,COG0850@2|Bacteria,1RHVN@1224|Proteobacteria,1S6K8@1236|Gammaproteobacteria,1WW2J@135613|Chromatiales	135613|Chromatiales	D	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization	minC	-	-	ko:K03610	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	MinC_C,MinC_N
k59_348385_1	335543.Sfum_1544	6.2e-93	275.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,42MPQ@68525|delta/epsilon subdivisions,2WMP6@28221|Deltaproteobacteria,2MQF6@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
k59_1052084_1	1283300.ATXB01000001_gene1484	1.09e-76	247.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1XEAR@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_520785_2	1268237.G114_07032	2.82e-18	80.1	COG2963@1|root,COG2963@2|Bacteria,1NBFZ@1224|Proteobacteria,1SFDA@1236|Gammaproteobacteria,1Y65R@135624|Aeromonadales	135624|Aeromonadales	L	COG2963 Transposase and inactivated derivatives	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_173269_1	868595.Desca_1450	1.15e-80	249.0	COG1692@1|root,COG1692@2|Bacteria,1TR9P@1239|Firmicutes,24967@186801|Clostridia,2604A@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM metallophosphoesterase, MG_246 BB_0505 family	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
k59_700224_2	933262.AXAM01000094_gene2194	2.18e-15	73.9	2CDHP@1|root,32RXU@2|Bacteria,1N1BP@1224|Proteobacteria,42TPT@68525|delta/epsilon subdivisions,2WQE6@28221|Deltaproteobacteria,2MJZK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	RsbT co-antagonist protein rsbRD N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RsbRD_N
k59_807923_1	1348657.M622_11650	4.96e-65	206.0	COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,2VP6A@28216|Betaproteobacteria	28216|Betaproteobacteria	L	transposase IS204 IS1001 IS1096 IS1165 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_1230116_1	706587.Desti_5099	5.06e-60	195.0	COG0697@1|root,COG0697@2|Bacteria,1MUQ7@1224|Proteobacteria,42R74@68525|delta/epsilon subdivisions,2WMRT@28221|Deltaproteobacteria,2MRGD@213462|Syntrophobacterales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_520795_1	593907.Celgi_2579	1.24e-70	229.0	COG1070@1|root,COG1070@2|Bacteria,2GVSJ@201174|Actinobacteria,4F0P1@85016|Cellulomonadaceae	201174|Actinobacteria	G	PFAM Carbohydrate kinase, FGGY-like	araB	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
k59_640054_3	1122185.N792_05600	5.6e-50	174.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1X3J8@135614|Xanthomonadales	135614|Xanthomonadales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_180914_1	1340493.JNIF01000003_gene2495	7.67e-10	63.2	COG0128@1|root,COG0128@2|Bacteria,3Y3RH@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_474419_1	1121405.dsmv_1836	7.29e-33	125.0	COG1181@1|root,COG1181@2|Bacteria,1MX3I@1224|Proteobacteria,42SA1@68525|delta/epsilon subdivisions,2WNIR@28221|Deltaproteobacteria,2MIAX@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
k59_946667_1	1304275.C41B8_01385	2.68e-92	282.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_1589409_1	360910.BAV0859	1.16e-96	304.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,3T1CV@506|Alcaligenaceae	28216|Betaproteobacteria	C	malic enzyme	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
k59_650589_1	338969.Rfer_1850	2.1e-66	234.0	2D125@1|root,32T9R@2|Bacteria,1N30F@1224|Proteobacteria,2VX2H@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_180921_1	314254.OA2633_10509	4.62e-91	281.0	COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,2TREH@28211|Alphaproteobacteria,43W7P@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
k59_474426_1	367299.JOEE01000004_gene1030	1.22e-76	239.0	COG1181@1|root,COG1181@2|Bacteria,2HP1M@201174|Actinobacteria,4FJZK@85021|Intrasporangiaceae	201174|Actinobacteria	M	Belongs to the D-alanine--D-alanine ligase family	-	-	-	-	-	-	-	-	-	-	-	-	Dala_Dala_lig_C
k59_474426_2	1385521.N803_02070	5.26e-39	135.0	COG4947@1|root,COG4947@2|Bacteria,2I9H9@201174|Actinobacteria,4FFF6@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_1472640_1	471853.Bcav_3272	1.86e-12	67.8	COG2160@1|root,COG2160@2|Bacteria,2GJNB@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the conversion of L-arabinose to L-ribulose	araA	-	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	-	Arabinose_Iso_C,Arabinose_Isome
k59_1472640_2	1035308.AQYY01000001_gene3366	3.65e-145	412.0	COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,248KI@186801|Clostridia,261R6@186807|Peptococcaceae	186801|Clostridia	G	PFAM Class II aldolase	araD	-	4.1.2.17,5.1.3.4	ko:K01628,ko:K03077	ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120	M00550	R02262,R05850	RC00603,RC00604,RC01479	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00590	Aldolase_II
k59_1765612_1	1221522.B723_29310	6.38e-56	192.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria,1YPPQ@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	I	Acyl-CoA dehydrogenase N terminal	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_359463_1	1453503.AU05_24730	6.99e-70	221.0	COG0604@1|root,COG0604@2|Bacteria,1MXCV@1224|Proteobacteria,1S13Q@1236|Gammaproteobacteria,1YCZ2@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_826378_1	1123393.KB891328_gene703	6.49e-148	423.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2VIIQ@28216|Betaproteobacteria,1KSPD@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Dehydrogenase E1 component	-	-	-	-	-	-	-	-	-	-	-	-	E1_dh
k59_533221_1	1265313.HRUBRA_01894	3.85e-27	114.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1J4IX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins	ftsK	GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1827017_1	557598.LHK_02092	7.52e-15	71.6	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2VR8D@28216|Betaproteobacteria	28216|Betaproteobacteria	CO	Periplasmic protein thiol	ccmG	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
k59_1827017_2	1283300.ATXB01000001_gene2163	2.26e-40	140.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,1S9DV@1236|Gammaproteobacteria,1XFD6@135618|Methylococcales	135618|Methylococcales	P	subunit of a heme lyase	ccmH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
k59_1827017_3	580332.Slit_1790	0.000614	43.1	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2VQ05@28216|Betaproteobacteria,44V8W@713636|Nitrosomonadales	28216|Betaproteobacteria	O	TIGRFAM cytochrome c-type biogenesis protein CcmI	cycH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_2
k59_767299_1	998674.ATTE01000001_gene4478	1.14e-130	380.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,1RMAZ@1236|Gammaproteobacteria,460GX@72273|Thiotrichales	72273|Thiotrichales	E	branched-chain amino acid transport system, permease component	-	-	-	ko:K11961	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
k59_767299_2	2340.JV46_28510	3.95e-77	245.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,1RQXD@1236|Gammaproteobacteria,1J5EH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	urtB	-	-	ko:K11960	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2,HEAT_2
k59_888995_1	1049564.TevJSym_ap00450	5.64e-92	293.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1J4HS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_1355756_1	1463825.JNXC01000001_gene5867	4.04e-62	197.0	COG0586@1|root,COG0586@2|Bacteria,2GKGR@201174|Actinobacteria,4DX3S@85010|Pseudonocardiales	201174|Actinobacteria	S	SNARE associated Golgi protein	yqjA	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
k59_1355756_2	1122130.AUHN01000009_gene743	6.32e-11	63.2	COG2035@1|root,COG2035@2|Bacteria,2I8HU@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	ko:K08974	-	-	-	-	ko00000	-	-	-	DUF368
k59_1002885_1	1163617.SCD_n01730	7.7e-68	233.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJI0@28216|Betaproteobacteria	28216|Betaproteobacteria	P	von Willebrand factor (vWF) type A domain	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA_2
k59_1062864_1	439235.Dalk_0717	2.67e-37	130.0	COG1846@1|root,COG1846@2|Bacteria,1QUMZ@1224|Proteobacteria,42T2Y@68525|delta/epsilon subdivisions,2WPRZ@28221|Deltaproteobacteria,2MK9Z@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,Methyltransf_14
k59_1414758_1	313589.JNB_02385	1.99e-19	84.7	COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,4FF7D@85021|Intrasporangiaceae	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA1	GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.11,2.7.8.5	ko:K00995,ko:K00999	ko00562,ko00564,ko01100,ko04070,map00562,map00564,map01100,map04070	-	R01801,R01802	RC00002,RC00017,RC00078,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_1414758_2	367299.JOEE01000008_gene524	2.5e-52	173.0	COG1560@1|root,COG1560@2|Bacteria,2GM7B@201174|Actinobacteria,4FFN3@85021|Intrasporangiaceae	201174|Actinobacteria	M	lipid A biosynthesis acyltransferase	htrB	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.3.1.265	ko:K22311	-	-	-	-	ko00000,ko01000	-	-	-	Lip_A_acyltrans
k59_1590196_1	754476.Q7A_2785	4.85e-30	117.0	COG0446@1|root,COG0446@2|Bacteria,1QUQF@1224|Proteobacteria,1RP1H@1236|Gammaproteobacteria,46027@72273|Thiotrichales	72273|Thiotrichales	S	PFAM Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1590196_2	631362.Thi970DRAFT_01985	4.37e-11	62.4	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1WVYY@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM isocitrate dehydrogenase, NADP-dependent	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,Iso_dh
k59_299348_1	8128.ENSONIP00000008514	1.22e-19	90.5	COG1028@1|root,KOG4169@2759|Eukaryota,39MT4@33154|Opisthokonta,3BJE1@33208|Metazoa,3D0NN@33213|Bilateria,484CP@7711|Chordata,48YH1@7742|Vertebrata,49WMZ@7898|Actinopterygii	33208|Metazoa	Q	Belongs to the short-chain dehydrogenases reductases (SDR) family	HPGD	GO:0000003,GO:0000166,GO:0001568,GO:0001655,GO:0001676,GO:0001822,GO:0001944,GO:0002237,GO:0003674,GO:0003824,GO:0004888,GO:0004930,GO:0004953,GO:0004954,GO:0004955,GO:0004957,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006636,GO:0006690,GO:0006692,GO:0006693,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007178,GO:0007179,GO:0007186,GO:0007275,GO:0007276,GO:0007292,GO:0007565,GO:0007567,GO:0008150,GO:0008152,GO:0008284,GO:0008610,GO:0009058,GO:0009605,GO:0009607,GO:0009617,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009987,GO:0010033,GO:0010941,GO:0010942,GO:0014070,GO:0016053,GO:0016404,GO:0016491,GO:0016614,GO:0016616,GO:0019372,GO:0019752,GO:0019953,GO:0022414,GO:0023052,GO:0030728,GO:0031974,GO:0031981,GO:0032355,GO:0032496,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0033559,GO:0033993,GO:0035239,GO:0035295,GO:0036094,GO:0038023,GO:0042127,GO:0042221,GO:0042493,GO:0042759,GO:0042802,GO:0042803,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043167,GO:0043168,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044421,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044706,GO:0045471,GO:0045786,GO:0046394,GO:0046456,GO:0046677,GO:0046983,GO:0048037,GO:0048513,GO:0048514,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048609,GO:0048660,GO:0048661,GO:0048731,GO:0048844,GO:0048856,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051287,GO:0051704,GO:0051707,GO:0051716,GO:0051726,GO:0055114,GO:0060089,GO:0060840,GO:0065007,GO:0070013,GO:0070403,GO:0070493,GO:0070848,GO:0070887,GO:0071310,GO:0071363,GO:0071495,GO:0071559,GO:0071560,GO:0071704,GO:0072001,GO:0072330,GO:0072358,GO:0072359,GO:0097070,GO:0097159,GO:0097305,GO:1901265,GO:1901363,GO:1901568,GO:1901570,GO:1901576,GO:1901700,GO:1904705,GO:1904707,GO:2001300,GO:2001301	1.1.1.141	ko:K00069	ko05202,map05202	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	adh_short
k59_1300132_1	1121403.AUCV01000001_gene686	6.61e-08	53.1	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2WJBH@28221|Deltaproteobacteria,2MJ0H@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_1300132_2	472759.Nhal_3150	1.29e-106	313.0	COG0569@1|root,COG0569@2|Bacteria,1RDDX@1224|Proteobacteria,1S3ZR@1236|Gammaproteobacteria,1WY9A@135613|Chromatiales	135613|Chromatiales	C	TrkA-N domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_947931_1	1206720.BAFQ01000233_gene5429	4.21e-20	89.7	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria,4FYN3@85025|Nocardiaceae	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_947931_2	309801.trd_1627	2.15e-16	78.2	COG0115@1|root,COG0115@2|Bacteria,2G6AX@200795|Chloroflexi,27Y0I@189775|Thermomicrobia	189775|Thermomicrobia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_889012_1	631362.Thi970DRAFT_02291	1.29e-52	184.0	COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,1WWRD@135613|Chromatiales	135613|Chromatiales	M	HAD-superfamily hydrolase, subfamily IIB	-	-	2.4.1.14	ko:K00696	ko00500,ko01100,map00500,map01100	-	R00766	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth
k59_889012_2	323261.Noc_3070	3.28e-22	92.8	COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,1RRWT@1236|Gammaproteobacteria,1WXVN@135613|Chromatiales	135613|Chromatiales	G	PfkB domain protein	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_1473850_1	313589.JNB_09879	2.87e-95	286.0	COG3409@1|root,COG3409@2|Bacteria,2I5WU@201174|Actinobacteria,4FEA8@85021|Intrasporangiaceae	201174|Actinobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
k59_1590202_1	257310.BB0872	1.15e-124	365.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2VMBX@28216|Betaproteobacteria,3T1V3@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	GO:0000287,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009157,GO:0009162,GO:0009165,GO:0009176,GO:0009177,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032259,GO:0034641,GO:0034654,GO:0042083,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046073,GO:0046385,GO:0046483,GO:0046872,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
k59_1649624_1	1122933.JNIY01000003_gene958	7.2e-105	325.0	COG3590@1|root,COG3590@2|Bacteria,2GNJY@201174|Actinobacteria,4F0H2@85016|Cellulomonadaceae	201174|Actinobacteria	O	Peptidase family M13	pepO	-	3.4.24.11,3.4.24.71	ko:K01389,ko:K01415,ko:K07386	ko04614,ko04640,ko04974,ko05010,map04614,map04640,map04974,map05010	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
k59_767986_1	1144319.PMI16_01789	1.08e-20	95.9	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,4739P@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Peptidase family M48	yggG_1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
k59_67228_1	526225.Gobs_4844	1.77e-83	254.0	2BYH3@1|root,2Z7SZ@2|Bacteria,2GMTF@201174|Actinobacteria,4ERHT@85013|Frankiales	201174|Actinobacteria	S	3-methyladenine DNA glycosylase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_8236_1	1385520.N802_19245	9.21e-26	101.0	COG0528@1|root,COG0528@2|Bacteria,2GKWQ@201174|Actinobacteria,4FE89@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_8236_2	1193181.BN10_1590028	1.65e-71	218.0	COG0233@1|root,COG0233@2|Bacteria,2GJ9J@201174|Actinobacteria,4FF1S@85021|Intrasporangiaceae	201174|Actinobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_592772_1	1049564.TevJSym_ab00640	3.31e-102	304.0	COG1136@1|root,COG1136@2|Bacteria,1RCXK@1224|Proteobacteria,1S7TZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	abc transporter atp-binding protein	attE	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_592772_2	1049564.TevJSym_ab00650	1.57e-144	430.0	COG2304@1|root,COG2304@2|Bacteria,1MXU0@1224|Proteobacteria,1RZHF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	serine threonine protein kinase	ppkA	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	VWA,VWA_2
k59_651514_1	1049564.TevJSym_ap00800	1.52e-102	304.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,1J4RX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	GO:0001676,GO:0003674,GO:0003824,GO:0003989,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009987,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0032787,GO:0032991,GO:0042759,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576,GO:1902494,GO:1990234	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b0185,iBWG_1329.BWG_0177,iEC55989_1330.EC55989_0179,iECDH10B_1368.ECDH10B_0165,iECDH1ME8569_1439.ECDH1ME8569_0178,iECED1_1282.ECED1_0191,iECH74115_1262.ECH74115_0195,iECIAI1_1343.ECIAI1_0185,iECNA114_1301.ECNA114_0175,iECO111_1330.ECO111_0186,iECO26_1355.ECO26_0187,iECP_1309.ECP_0193,iECSE_1348.ECSE_0184,iECSF_1327.ECSF_0200,iECSP_1301.ECSP_0184,iECW_1372.ECW_m0181,iECs_1301.ECs0187,iEKO11_1354.EKO11_3733,iEcDH1_1363.EcDH1_3418,iEcE24377_1341.EcE24377A_0189,iEcHS_1320.EcHS_A0187,iG2583_1286.G2583_0188,iJN746.PP_1607,iJO1366.b0185,iJR904.b0185,iLF82_1304.LF82_0008,iNRG857_1313.NRG857_00945,iSDY_1059.SDY_0201,iSFV_1184.SFV_0168,iSF_1195.SF0175,iSFxv_1172.SFxv_0185,iS_1188.S0178,iUMNK88_1353.UMNK88_190,iWFL_1372.ECW_m0181,iY75_1357.Y75_RS00935,iZ_1308.Z0197	ACCA
k59_1355779_1	1286106.MPL1_05419	3.85e-68	216.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,4610F@72273|Thiotrichales	72273|Thiotrichales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
k59_947946_2	1123274.KB899408_gene3975	8.52e-33	126.0	COG0438@1|root,COG0438@2|Bacteria,2J6VH@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
k59_299363_1	1123371.ATXH01000016_gene1861	4.86e-13	73.9	COG1450@1|root,COG1450@2|Bacteria,2GI8Z@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	NU	Bacterial type II/III secretion system short domain	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_1473870_1	439235.Dalk_3801	5.51e-94	286.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42MTH@68525|delta/epsilon subdivisions,2WJQY@28221|Deltaproteobacteria,2MK6I@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM inner-membrane translocator	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1238950_1	396014.BF93_17015	3.54e-89	268.0	COG0378@1|root,COG0378@2|Bacteria,2GNUV@201174|Actinobacteria,4FBJB@85020|Dermabacteraceae	201174|Actinobacteria	KO	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG	ureG	-	-	ko:K03189	-	-	-	-	ko00000	-	-	-	cobW
k59_8256_1	1123392.AQWL01000002_gene1719	2.09e-53	174.0	COG2010@1|root,COG2010@2|Bacteria,1N0EF@1224|Proteobacteria,2VT6G@28216|Betaproteobacteria,1KT3M@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_1062899_1	1127673.GLIP_1552	2.04e-07	58.9	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S720@1236|Gammaproteobacteria,468K9@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_8,Trans_reg_C
k59_1238953_1	929556.Solca_3372	7.54e-06	53.1	COG4206@1|root,COG4774@1|root,COG4206@2|Bacteria,COG4774@2|Bacteria,4NZWU@976|Bacteroidetes,1IQ5H@117747|Sphingobacteriia	976|Bacteroidetes	H	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_242148_1	1232683.ADIMK_0347	1.06e-66	222.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,4650A@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Catalyzes cross-linking of the peptidoglycan cell wall at the division septum	ftsI	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	iSSON_1240.SSON_0092	PBP_dimer,Transpeptidase
k59_1649644_1	870187.Thini_4375	5.58e-28	112.0	COG3335@1|root,COG3335@2|Bacteria,1N2JC@1224|Proteobacteria,1S21X@1236|Gammaproteobacteria	1224|Proteobacteria	L	PFAM Rhodopirellula transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
k59_1649644_2	870187.Thini_4375	2.12e-44	155.0	COG3335@1|root,COG3335@2|Bacteria,1N2JC@1224|Proteobacteria,1S21X@1236|Gammaproteobacteria	1224|Proteobacteria	L	PFAM Rhodopirellula transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
k59_1002918_1	1122951.ATUE01000005_gene2206	2.86e-122	379.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,3NIFC@468|Moraxellaceae	1236|Gammaproteobacteria	F	Carbamoyl-phosphate synthetase ammonia chain	carB	GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041	CPSase_L_D2,CPSase_L_D3,MGS
k59_1300177_1	1121405.dsmv_2181	1.1e-107	320.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,42M15@68525|delta/epsilon subdivisions,2WIQN@28221|Deltaproteobacteria,2MI44@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_1473890_1	690850.Desaf_2364	3.75e-71	231.0	28HC9@1|root,2Z7P5@2|Bacteria,1R4BH@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_242166_1	926692.AZYG01000085_gene856	3.32e-62	205.0	COG2801@1|root,COG2801@2|Bacteria,1TU21@1239|Firmicutes,249HN@186801|Clostridia,3WA8E@53433|Halanaerobiales	186801|Clostridia	L	Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_360718_1	290397.Adeh_3905	4.34e-122	372.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,42P3R@68525|delta/epsilon subdivisions,2X349@28221|Deltaproteobacteria,2YU6W@29|Myxococcales	28221|Deltaproteobacteria	H	Malate synthase	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_1766443_1	471853.Bcav_0875	1.15e-71	229.0	COG0477@1|root,COG2814@2|Bacteria,2I2EY@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	pimH	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_592794_1	312284.A20C1_05801	1.98e-33	132.0	COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria	201174|Actinobacteria	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441,ko:K10562	ko02010,map02010	M00212,M00220	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.9	-	-	ABC_tran
k59_651540_1	440512.C211_16650	2.23e-134	395.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_1708021_1	1283300.ATXB01000001_gene1873	4.61e-67	218.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1S14K@1236|Gammaproteobacteria,1XG9Y@135618|Methylococcales	135618|Methylococcales	J	tRNA synthetases class I (E and Q), catalytic domain	-	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_889059_1	1121939.L861_22870	6.14e-06	48.1	COG2230@1|root,COG2230@2|Bacteria,1QY55@1224|Proteobacteria,1RYEN@1236|Gammaproteobacteria,1XNR9@135619|Oceanospirillales	135619|Oceanospirillales	M	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_889059_2	1410638.JHXJ01000007_gene1154	0.000167	47.0	COG1309@1|root,COG1309@2|Bacteria,1TP2E@1239|Firmicutes,24JHY@186801|Clostridia,3WG9D@541000|Ruminococcaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_768006_1	335283.Neut_2067	8.6e-149	429.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,3723Q@32003|Nitrosomonadales	28216|Betaproteobacteria	E	PFAM aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_947980_1	1121405.dsmv_1864	4.45e-48	166.0	COG0524@1|root,COG0524@2|Bacteria,1Q1GY@1224|Proteobacteria,42REZ@68525|delta/epsilon subdivisions,2WNHE@28221|Deltaproteobacteria,2MND3@213118|Desulfobacterales	28221|Deltaproteobacteria	G	PFAM PfkB	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_123101_1	1432050.IE4771_CH02658	1.51e-65	213.0	2C1EG@1|root,2Z7MZ@2|Bacteria,1NQTP@1224|Proteobacteria,2UPDR@28211|Alphaproteobacteria,4BAAM@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_123101_2	67352.JODS01000055_gene2239	7.24e-36	125.0	2C3KP@1|root,2Z802@2|Bacteria,2IFTZ@201174|Actinobacteria	201174|Actinobacteria	S	phage tail protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_181839_1	765911.Thivi_3823	5.23e-50	170.0	COG1808@1|root,COG1808@2|Bacteria,1NMS3@1224|Proteobacteria,1RRTC@1236|Gammaproteobacteria,1WWHR@135613|Chromatiales	135613|Chromatiales	I	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
k59_416445_1	933262.AXAM01000041_gene1892	3.97e-87	276.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2MJ2X@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_534160_2	1122915.AUGY01000001_gene7137	1.44e-06	49.3	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,4HBZR@91061|Bacilli,26WMX@186822|Paenibacillaceae	91061|Bacilli	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	merA	-	1.16.1.1	ko:K00520	-	-	-	-	ko00000,ko01000	-	-	-	HMA,Pyr_redox_2,Pyr_redox_dim
k59_1828326_1	754477.Q7C_347	8.63e-136	395.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,1RNXH@1236|Gammaproteobacteria,4602Y@72273|Thiotrichales	72273|Thiotrichales	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1473915_1	1121405.dsmv_3532	5.69e-55	189.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,42P6S@68525|delta/epsilon subdivisions,2WIWC@28221|Deltaproteobacteria,2MI1I@213118|Desulfobacterales	28221|Deltaproteobacteria	EQ	PFAM Hydantoinase oxoprolinase	-	-	-	-	-	-	-	-	-	-	-	-	Hydant_A_N,Hydantoinase_A
k59_1238992_1	1304865.JAGF01000001_gene2737	1.52e-27	113.0	COG1196@1|root,COG3599@1|root,COG1196@2|Bacteria,COG3599@2|Bacteria,2I2UK@201174|Actinobacteria,4F0XQ@85016|Cellulomonadaceae	201174|Actinobacteria	D	regulation of cell shape	-	-	-	-	-	-	-	-	-	-	-	-	DivIVA
k59_827355_1	1122176.KB903536_gene1763	2.91e-26	112.0	COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,1IUW9@117747|Sphingobacteriia	976|Bacteroidetes	H	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_369611_1	335543.Sfum_1559	4.14e-59	182.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,42THY@68525|delta/epsilon subdivisions,2WQ0F@28221|Deltaproteobacteria,2MRYJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_369611_2	335543.Sfum_1560	2.04e-18	78.2	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,42TRE@68525|delta/epsilon subdivisions,2WQBH@28221|Deltaproteobacteria,2MS4P@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_254144_1	367299.JOEE01000003_gene2738	2.87e-60	206.0	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4FE65@85021|Intrasporangiaceae	201174|Actinobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_1421634_1	573064.Mefer_1140	4.48e-09	57.4	COG1120@1|root,arCOG00199@2157|Archaea,2XTTV@28890|Euryarchaeota,23QCG@183939|Methanococci	183939|Methanococci	P	PFAM ABC transporter related	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_1421634_2	1156919.QWC_30208	2.01e-79	244.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJM6@28216|Betaproteobacteria,3T22A@506|Alcaligenaceae	28216|Betaproteobacteria	E	ABC-type branched-chain amino acid transport systems ATPase component	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_598716_1	278957.ABEA03000041_gene2139	1.42e-89	280.0	COG0129@1|root,COG0129@2|Bacteria,46SBY@74201|Verrucomicrobia,3K7M4@414999|Opitutae	414999|Opitutae	EG	Dehydratase family	-	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_1309010_1	717785.HYPMC_2776	3.54e-179	508.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2TQKT@28211|Alphaproteobacteria,3N69A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_1186660_1	1530085.A0A077K814_9CAUD	9.34e-63	202.0	4QBAD@10239|Viruses,4QPAI@28883|Caudovirales,4QK7N@10662|Myoviridae	10662|Myoviridae	S	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1186660_2	522373.Smlt0783	1.21e-05	48.1	COG1988@1|root,COG1988@2|Bacteria,1QK5N@1224|Proteobacteria,1S0MU@1236|Gammaproteobacteria,1X507@135614|Xanthomonadales	135614|Xanthomonadales	S	membrane-bound metal-dependent	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
k59_481601_1	593750.Metfor_1509	7.78e-41	146.0	arCOG02396@1|root,arCOG02396@2157|Archaea,2Y4TY@28890|Euryarchaeota,2NBCN@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_76085_1	999141.GME_14510	1.22e-94	292.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1XHSK@135619|Oceanospirillales	135619|Oceanospirillales	J	SAM-dependent	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
k59_254157_1	396595.TK90_2485	3.83e-37	126.0	COG2924@1|root,COG2924@2|Bacteria,1MZ2V@1224|Proteobacteria,1S964@1236|Gammaproteobacteria,1WYU9@135613|Chromatiales	135613|Chromatiales	CO	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Iron_traffic
k59_254157_2	472759.Nhal_3020	1.19e-10	60.8	COG3514@1|root,COG3514@2|Bacteria,1N7UF@1224|Proteobacteria,1SE0J@1236|Gammaproteobacteria,1X1NQ@135613|Chromatiales	135613|Chromatiales	S	BrnA antitoxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	BrnA_antitoxin
k59_1008207_1	1049564.TevJSym_ax00160	7.56e-119	349.0	COG0446@1|root,COG0446@2|Bacteria,1QUQF@1224|Proteobacteria,1RP1H@1236|Gammaproteobacteria,1J9DV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	sqr	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1008207_2	768671.ThimaDRAFT_0595	4.68e-49	164.0	COG3258@1|root,COG3258@2|Bacteria,1MZJW@1224|Proteobacteria,1S2EF@1236|Gammaproteobacteria,1WY2H@135613|Chromatiales	135613|Chromatiales	C	Protein of unknown function (DUF3365)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365
k59_20599_1	933262.AXAM01000055_gene1255	5.6e-103	312.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,42M48@68525|delta/epsilon subdivisions,2WISV@28221|Deltaproteobacteria,2MIBH@213118|Desulfobacterales	28221|Deltaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_481610_1	1249627.D779_2827	1.37e-64	220.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1WWH1@135613|Chromatiales	135613|Chromatiales	M	TIGRFAM penicillin-binding protein, 1A	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_834018_1	392500.Swoo_0647	1.25e-55	195.0	COG1404@1|root,COG3291@1|root,COG4935@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG4935@2|Bacteria,1MU3S@1224|Proteobacteria,1RSP9@1236|Gammaproteobacteria,2Q9PE@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Proprotein convertase P-domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD,P_proprotein,Peptidase_S8
k59_1186671_1	398512.JQKC01000017_gene3085	1.48e-64	205.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,3WHG1@541000|Ruminococcaceae	186801|Clostridia	E	ABC transporter, ATP-binding protein	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_956909_1	572477.Alvin_0867	2.04e-50	171.0	COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,1RRRE@1236|Gammaproteobacteria,1WVUP@135613|Chromatiales	135613|Chromatiales	M	Lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_188592_1	998088.B565_0362	3.31e-79	240.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1Y5JW@135624|Aeromonadales	135624|Aeromonadales	V	Ami_2	-	-	3.5.1.28	ko:K03806	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	Amidase_2
k59_188592_2	396588.Tgr7_0629	6.45e-32	116.0	COG0526@1|root,COG0526@2|Bacteria,1NC9Q@1224|Proteobacteria,1T0R2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
k59_1837263_2	1300345.LF41_335	1.47e-48	168.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1X4K3@135614|Xanthomonadales	135614|Xanthomonadales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_658230_1	670307.HYPDE_23013	8.67e-47	160.0	COG4221@1|root,COG4221@2|Bacteria,1QVS5@1224|Proteobacteria	1224|Proteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_598743_1	1384056.N787_02755	7.77e-22	96.3	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1X7DH@135614|Xanthomonadales	135614|Xanthomonadales	T	Putative nucleotidyltransferase substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_716853_1	1041826.FCOL_10670	7.28e-12	66.2	COG0607@1|root,COG0607@2|Bacteria,4NSD1@976|Bacteroidetes,1I4FW@117743|Flavobacteriia,2NX6I@237|Flavobacterium	976|Bacteroidetes	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_716853_2	72004.XP_005899364.1	0.000268	44.3	COG0695@1|root,KOG1752@2759|Eukaryota,3A6RB@33154|Opisthokonta,3BSKM@33208|Metazoa,3D86X@33213|Bilateria,48F6F@7711|Chordata,49C93@7742|Vertebrata,3JHD7@40674|Mammalia,4J5S0@91561|Cetartiodactyla	33208|Metazoa	O	protein disulfide oxidoreductase activity	GLRX	GO:0000003,GO:0001678,GO:0002028,GO:0002791,GO:0002793,GO:0002931,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005829,GO:0006139,GO:0006464,GO:0006725,GO:0006807,GO:0006950,GO:0007568,GO:0008150,GO:0008152,GO:0009719,GO:0009725,GO:0009743,GO:0009746,GO:0009749,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010033,GO:0010640,GO:0010642,GO:0010646,GO:0010647,GO:0010648,GO:0010765,GO:0010817,GO:0010941,GO:0010959,GO:0014070,GO:0015035,GO:0015036,GO:0015037,GO:0015038,GO:0015949,GO:0016491,GO:0016667,GO:0016671,GO:0017157,GO:0019153,GO:0019538,GO:0019725,GO:0019899,GO:0022414,GO:0022602,GO:0022898,GO:0023051,GO:0023056,GO:0023057,GO:0030425,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032024,GO:0032355,GO:0032409,GO:0032411,GO:0032412,GO:0032414,GO:0032501,GO:0032502,GO:0032504,GO:0032870,GO:0032879,GO:0032880,GO:0033500,GO:0033993,GO:0034284,GO:0034641,GO:0034762,GO:0034764,GO:0034765,GO:0034767,GO:0036211,GO:0036477,GO:0042221,GO:0042391,GO:0042592,GO:0042593,GO:0042698,GO:0042995,GO:0043005,GO:0043025,GO:0043067,GO:0043069,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043269,GO:0043270,GO:0043412,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044297,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044463,GO:0044464,GO:0045838,GO:0045921,GO:0046483,GO:0046883,GO:0046887,GO:0047485,GO:0048511,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0048609,GO:0048878,GO:0050708,GO:0050714,GO:0050789,GO:0050794,GO:0050796,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051117,GO:0051222,GO:0051223,GO:0051716,GO:0055082,GO:0055086,GO:0055114,GO:0060353,GO:0060355,GO:0060548,GO:0060627,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070201,GO:0070887,GO:0071310,GO:0071322,GO:0071326,GO:0071331,GO:0071333,GO:0071392,GO:0071396,GO:0071407,GO:0071495,GO:0071704,GO:0080058,GO:0080134,GO:0080135,GO:0090087,GO:0090276,GO:0090277,GO:0097447,GO:0097458,GO:0097573,GO:0120025,GO:0120038,GO:1900407,GO:1900408,GO:1901031,GO:1901032,GO:1901222,GO:1901224,GO:1901298,GO:1901299,GO:1901360,GO:1901564,GO:1901700,GO:1901701,GO:1902305,GO:1902307,GO:1902531,GO:1902533,GO:1902882,GO:1902883,GO:1903201,GO:1903202,GO:1903205,GO:1903206,GO:1903530,GO:1903532,GO:1904062,GO:1904064,GO:1904951,GO:2000586,GO:2000587,GO:2000649,GO:2000651,GO:2001023,GO:2001024,GO:2001038,GO:2001039	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
k59_1248106_1	1122603.ATVI01000006_gene624	2.97e-65	218.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1X4NS@135614|Xanthomonadales	135614|Xanthomonadales	M	Lytic murein transglycosylase	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
k59_369649_1	743719.PaelaDRAFT_3775	9.28e-77	263.0	COG2909@1|root,COG2909@2|Bacteria,1UIMV@1239|Firmicutes,4HD7H@91061|Bacilli,26QDM@186822|Paenibacillaceae	91061|Bacilli	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
k59_773288_2	1288494.EBAPG3_2190	3.45e-73	239.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,2VIHA@28216|Betaproteobacteria,3725Z@32003|Nitrosomonadales	28216|Betaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh
k59_540466_1	631362.Thi970DRAFT_04024	1.13e-23	92.4	COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,1SCPF@1236|Gammaproteobacteria,1WZC1@135613|Chromatiales	135613|Chromatiales	C	acylphosphatase	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
k59_540466_2	666681.M301_2439	1.35e-30	115.0	COG0526@1|root,COG0526@2|Bacteria,1N4HY@1224|Proteobacteria,2VSKM@28216|Betaproteobacteria,2KN5X@206350|Nitrosomonadales	206350|Nitrosomonadales	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_1125735_1	1265313.HRUBRA_00054	2.22e-09	56.6	COG2165@1|root,COG2165@2|Bacteria,1N737@1224|Proteobacteria,1SC8X@1236|Gammaproteobacteria,1J78U@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	COG2165 Type II secretory pathway, pseudopilin PulG	gspI	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K02458	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSI
k59_1125735_2	1123020.AUIE01000030_gene2624	5.04e-05	48.1	COG2165@1|root,COG2165@2|Bacteria,1N7HZ@1224|Proteobacteria,1SCWD@1236|Gammaproteobacteria,1YG6I@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	U	Type II transport protein GspH	gspH	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspH,N_methyl
k59_254195_1	1035308.AQYY01000001_gene1207	1.2e-102	327.0	COG1038@1|root,COG1038@2|Bacteria,1UHP9@1239|Firmicutes,25E5B@186801|Clostridia,2603N@186807|Peptococcaceae	186801|Clostridia	C	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second	pyc	-	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS18410	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA
k59_369658_1	1429046.RR21198_5247	1.65e-85	271.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,4G5UB@85025|Nocardiaceae	201174|Actinobacteria	M	Exporter of polyketide	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_305440_1	446469.Sked_17950	7.05e-76	233.0	COG2065@1|root,COG2065@2|Bacteria,2GJNP@201174|Actinobacteria	201174|Actinobacteria	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
k59_188606_1	45157.CMP017CT	9.01e-23	102.0	COG1355@1|root,KOG3086@2759|Eukaryota	2759|Eukaryota	O	regulation of microtubule-based process	-	GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0008150,GO:0032886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
k59_658245_1	314285.KT71_02627	1.08e-56	200.0	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S0KQ@1236|Gammaproteobacteria,1J82F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_369659_1	626887.J057_08786	4.72e-28	121.0	COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,4650G@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG0643 Chemotaxis protein histidine kinase and related kinases	chpA	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_1008230_1	765912.Thimo_1486	2.17e-88	272.0	COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,1RQ6N@1236|Gammaproteobacteria,1WWGR@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1008230_2	765911.Thivi_1788	6.66e-21	88.2	COG1394@1|root,COG1394@2|Bacteria,1PA1A@1224|Proteobacteria,1S17V@1236|Gammaproteobacteria,1WWE8@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
k59_897932_1	1049564.TevJSym_bb00140	6.34e-84	256.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1J4VC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	COG4972 Tfp pilus assembly protein, ATPase PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_897932_2	314278.NB231_06141	4.57e-07	50.4	COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,1S3S0@1236|Gammaproteobacteria,1WY4Z@135613|Chromatiales	135613|Chromatiales	NU	PFAM Fimbrial assembly	-	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
k59_1309067_1	937777.Deipe_2185	6.9e-24	107.0	COG1132@1|root,COG1132@2|Bacteria,1WJ5B@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
k59_254206_1	1229781.C272_03075	1.65e-68	220.0	COG0167@1|root,COG0167@2|Bacteria,2GKC6@201174|Actinobacteria,4F95M@85019|Brevibacteriaceae	201174|Actinobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.3.5.2,1.3.98.1	ko:K00226,ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01867,R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_598763_1	887898.HMPREF0551_0809	1.55e-28	115.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,1K1SA@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_598763_2	379731.PST_2365	8.14e-59	192.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1Z122@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iJN746.PP_2469	Phe_tRNA-synt_N,tRNA-synt_2d
k59_1538034_1	1231392.OCGS_2814	1.88e-53	179.0	COG2358@1|root,COG2358@2|Bacteria,1Q6GH@1224|Proteobacteria,2U1DH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transport system, periplasmic component	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_1837302_1	666685.R2APBS1_0866	6.17e-14	69.7	COG0835@1|root,COG0835@2|Bacteria,1NA8G@1224|Proteobacteria,1SCB2@1236|Gammaproteobacteria,1X6S4@135614|Xanthomonadales	135614|Xanthomonadales	NT	chemotaxis signal transduction protein	-	-	-	ko:K06598	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
k59_1837302_2	1114970.PSF113_5525	4e-43	157.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1YNX1@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	T	Histidine kinase	chpA	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_834047_1	1144275.COCOR_02763	9.37e-70	228.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,43BMQ@68525|delta/epsilon subdivisions,2X6ZS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_1421686_1	196162.Noca_1054	2.72e-67	219.0	COG2267@1|root,COG2267@2|Bacteria,2H0IK@201174|Actinobacteria,4DUF0@85009|Propionibacteriales	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
k59_1421686_2	1223521.BBJX01000005_gene1988	1.93e-44	162.0	COG1541@1|root,COG1541@2|Bacteria,1P22K@1224|Proteobacteria,2WGC2@28216|Betaproteobacteria,4ACC7@80864|Comamonadaceae	28216|Betaproteobacteria	H	coenzyme F390 synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
k59_897942_1	646529.Desaci_1877	7.48e-117	360.0	COG2185@1|root,COG2185@2|Bacteria,1UJHA@1239|Firmicutes,25F35@186801|Clostridia	186801|Clostridia	I	D-Lysine 5,6-aminomutase alpha subunit	-	-	5.4.3.5	ko:K17898	ko00472,map00472	-	R02461	RC00719	ko00000,ko00001,ko01000	-	-	-	B12-binding,Lys-AminoMut_A,OAM_dimer
k59_20657_1	1452718.JBOY01000167_gene1546	6.25e-155	447.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,1RMMT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_716884_2	105559.Nwat_3092	1.04e-29	115.0	COG1999@1|root,COG1999@2|Bacteria,1N6R6@1224|Proteobacteria,1SWXH@1236|Gammaproteobacteria,1X1CE@135613|Chromatiales	135613|Chromatiales	S	signal sequence binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1538038_1	1229203.KI301992_gene2419	1.08e-90	271.0	COG0053@1|root,COG0053@2|Bacteria,2GQJJ@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Cation efflux	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
k59_1538038_2	1206735.BAGG01000263_gene6662	8.29e-68	206.0	COG1742@1|root,COG1742@2|Bacteria,2IKM8@201174|Actinobacteria,4G23W@85025|Nocardiaceae	201174|Actinobacteria	S	Uncharacterised BCR, YnfA/UPF0060 family	-	GO:0005575,GO:0005576	-	ko:K09771	-	-	-	-	ko00000,ko02000	2.A.7.26	-	-	UPF0060
k59_189475_1	768671.ThimaDRAFT_1875	2e-125	374.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1WWTW@135613|Chromatiales	135613|Chromatiales	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
k59_659145_1	479431.Namu_2650	2.97e-153	446.0	COG1680@1|root,COG1680@2|Bacteria,2HF64@201174|Actinobacteria,4EW6D@85013|Frankiales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1838472_1	880072.Desac_2291	3.02e-62	205.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,42MU5@68525|delta/epsilon subdivisions,2WKWY@28221|Deltaproteobacteria,2MQI6@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
k59_1657346_1	765910.MARPU_10595	2.24e-103	332.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1WX8F@135613|Chromatiales	135613|Chromatiales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_77304_1	1049564.TevJSym_aa02130	2.57e-24	101.0	2B5QC@1|root,31YJX@2|Bacteria,1RIBA@1224|Proteobacteria,1SPMT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
k59_77304_2	335283.Neut_0196	6.33e-15	74.3	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,371QW@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
k59_306264_1	1032480.MLP_31370	7.24e-05	45.4	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,2H7WY@201174|Actinobacteria,4DQ82@85009|Propionibacteriales	201174|Actinobacteria	T	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	cdr	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
k59_1597302_1	477641.MODMU_4092	7.44e-18	82.8	COG5549@1|root,COG5549@2|Bacteria,2IJMT@201174|Actinobacteria,4EWQ1@85013|Frankiales	201174|Actinobacteria	O	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
k59_1597302_2	75379.Tint_0585	8.36e-23	95.1	COG0775@1|root,COG0775@2|Bacteria,1MY5S@1224|Proteobacteria,2VQBX@28216|Betaproteobacteria,1KKNE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	mtnN	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
k59_958128_1	96561.Dole_1225	2.35e-99	298.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42N9E@68525|delta/epsilon subdivisions,2WJAX@28221|Deltaproteobacteria,2MI1Z@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM domain protein	-	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_189484_1	1283300.ATXB01000001_gene817	3.68e-163	469.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,1XEM7@135618|Methylococcales	135618|Methylococcales	E	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
k59_541339_1	311403.Arad_9990	8.99e-34	133.0	COG4733@1|root,COG4733@2|Bacteria,1NJBA@1224|Proteobacteria,2UPZ7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Alginate lyase	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase
k59_1484398_1	1430440.MGMSRv2_1396	1.83e-34	126.0	COG1522@1|root,COG1522@2|Bacteria,1NVYY@1224|Proteobacteria,2U1S8@28211|Alphaproteobacteria,2JTI1@204441|Rhodospirillales	204441|Rhodospirillales	K	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
k59_306275_1	1049564.TevJSym_ad00290	4.92e-92	297.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,1J980@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2309)	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k59_130863_1	399741.Spro_1174	2.25e-14	77.0	COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,1S8Q2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	DSBA oxidoreductase	frnE	-	-	-	-	-	-	-	-	-	-	-	DSBA
k59_1838507_1	446466.Cfla_1210	7.99e-19	81.6	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	rsrA	GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141	-	-	-	-	-	-	-	-	-	-	zf-HC2
k59_1838507_2	219305.MCAG_00286	4.67e-12	64.7	COG0627@1|root,COG0627@2|Bacteria,2GJX4@201174|Actinobacteria,4D9HJ@85008|Micromonosporales	201174|Actinobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_1187600_1	76114.ebA4939	4.66e-08	53.1	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria,2KX8V@206389|Rhodocyclales	206389|Rhodocyclales	L	Group II intron, maturase-specific domain	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_1187600_2	1297570.MESS4_430119	6.32e-37	127.0	COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,2UB1M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG1943 Transposase and inactivated derivatives	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_1187600_3	1297570.MESS4_430119	8.43e-13	65.5	COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,2UB1M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG1943 Transposase and inactivated derivatives	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_255371_1	1121957.ATVL01000007_gene2276	2.15e-53	187.0	COG1770@1|root,COG1770@2|Bacteria,4NEQS@976|Bacteroidetes,47KWW@768503|Cytophagia	976|Bacteroidetes	E	PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_659177_1	768671.ThimaDRAFT_0622	5.43e-68	226.0	COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,1RQWX@1236|Gammaproteobacteria,1WZGU@135613|Chromatiales	135613|Chromatiales	C	PFAM Glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_1254404_1	338963.Pcar_0577	2.87e-58	194.0	COG3547@1|root,COG3547@2|Bacteria,1NCHY@1224|Proteobacteria,42TM4@68525|delta/epsilon subdivisions,2WR4U@28221|Deltaproteobacteria,43W2A@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1130015_1	1041147.AUFB01000094_gene5706	2.14e-212	598.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U1Z0@28211|Alphaproteobacteria,4BMWU@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986,ko:K15342	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	Cas_Cas1,GIIM,RVT_1
k59_603551_1	1232410.KI421425_gene1550	1.06e-55	191.0	COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,42Z0Q@68525|delta/epsilon subdivisions,2WU0G@28221|Deltaproteobacteria,43T6R@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_603551_2	1385517.N800_13135	4.86e-57	183.0	2B4XH@1|root,32REP@2|Bacteria,1RJ9F@1224|Proteobacteria,1T0SV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1080301_2	391625.PPSIR1_14115	4.97e-82	266.0	COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,437WU@68525|delta/epsilon subdivisions,2X9PZ@28221|Deltaproteobacteria,2YUI9@29|Myxococcales	28221|Deltaproteobacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_26829_2	313589.JNB_07239	7.03e-10	60.8	COG2135@1|root,COG2135@2|Bacteria,2GKY8@201174|Actinobacteria,4FF9J@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
k59_1080304_1	1502770.JQMG01000001_gene908	2.58e-59	197.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2VJ75@28216|Betaproteobacteria,2KNIV@206350|Nitrosomonadales	206350|Nitrosomonadales	P	NnrS protein	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
k59_904811_1	314264.ROS217_20127	1.03e-59	194.0	COG0746@1|root,COG0746@2|Bacteria,1QWF1@1224|Proteobacteria,2TWXS@28211|Alphaproteobacteria,46PA0@74030|Roseovarius	28211|Alphaproteobacteria	H	MobA-like NTP transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	HAD,NTP_transf_3
k59_1601192_1	351607.Acel_1847	4.53e-62	206.0	COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,4ES11@85013|Frankiales	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_427650_1	1380354.JIAN01000008_gene3600	7.49e-33	127.0	2C0QS@1|root,32R7D@2|Bacteria,2I5R9@201174|Actinobacteria,4F1Y4@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1191582_1	439235.Dalk_4515	3.74e-76	244.0	COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,43CRI@68525|delta/epsilon subdivisions,2X7Z7@28221|Deltaproteobacteria,2MIWI@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_1489202_1	479434.Sthe_0243	1.9e-11	70.5	COG2197@1|root,COG2197@2|Bacteria,2G6C5@200795|Chloroflexi	200795|Chloroflexi	K	COGs COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1489202_4	631362.Thi970DRAFT_04432	5.34e-88	273.0	COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,1T2D1@1236|Gammaproteobacteria,1X28U@135613|Chromatiales	135613|Chromatiales	P	Sodium/hydrogen exchanger family	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger
k59_721729_1	1266998.ATUJ01000002_gene1972	3e-35	136.0	COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2TSHG@28211|Alphaproteobacteria,2PYJ1@265|Paracoccus	28211|Alphaproteobacteria	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
k59_545054_1	661087.HMPREF1008_01229	1.84e-26	99.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria,4CWAW@84998|Coriobacteriia	84998|Coriobacteriia	K	'Cold-shock' DNA-binding domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_545054_2	1454004.AW11_01836	9.33e-15	75.1	COG1352@1|root,COG2201@1|root,COG5002@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2W0JH@28216|Betaproteobacteria	28216|Betaproteobacteria	T	sensor protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_4,PAS_9
k59_26845_2	693444.D782_2680	4.21e-13	68.9	COG3132@1|root,COG3132@2|Bacteria,1RA13@1224|Proteobacteria,1RQUQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the UPF0502 family	yceH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480
k59_134843_1	765910.MARPU_03690	2.04e-103	334.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1718880_1	1249627.D779_2667	4.73e-80	243.0	COG0529@1|root,COG0529@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria,1WY0V@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
k59_193494_1	765912.Thimo_0962	6.18e-101	310.0	COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1WWSK@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB
k59_83015_2	999541.bgla_1g09740	1.94e-58	192.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VIK8@28216|Betaproteobacteria,1K1W5@119060|Burkholderiaceae	28216|Betaproteobacteria	BQ	histone deacetylase	hdaH	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_1316022_1	1304865.JAGF01000001_gene3278	3.12e-77	253.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,2H7WY@201174|Actinobacteria,4F10M@85016|Cellulomonadaceae	201174|Actinobacteria	P	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	cdr	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
k59_838900_1	317655.Sala_2544	2.3e-20	95.5	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2K0EB@204457|Sphingomonadales	204457|Sphingomonadales	P	P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
k59_1367039_1	593907.Celgi_1428	3.99e-15	80.1	COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria,2GMC0@201174|Actinobacteria,4F105@85016|Cellulomonadaceae	201174|Actinobacteria	L	PFAM Exonuclease RNase T and DNA polymerase III	dnaQ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,UVR
k59_1080337_1	1182590.BN5_00285	1.56e-15	74.7	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,1YD38@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	F	Belongs to the RimK family	rimK	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
k59_663903_1	367299.JOEE01000014_gene932	4.39e-140	426.0	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,4FE8P@85021|Intrasporangiaceae	201174|Actinobacteria	S	UPF0182 protein	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_1012969_1	246197.MXAN_3583	2.13e-131	399.0	COG1164@1|root,COG1164@2|Bacteria,1Q3C4@1224|Proteobacteria,4393F@68525|delta/epsilon subdivisions,2X49B@28221|Deltaproteobacteria,2YYJ7@29|Myxococcales	28221|Deltaproteobacteria	E	Oligoendopeptidase f	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_487251_1	1121946.AUAX01000014_gene1107	1.99e-14	79.0	COG0699@1|root,COG0699@2|Bacteria,2GM68@201174|Actinobacteria,4DAXS@85008|Micromonosporales	201174|Actinobacteria	S	50S ribosome-binding GTPase	-	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
k59_1255446_1	498761.HM1_2755	5.68e-29	115.0	COG1893@1|root,COG1893@2|Bacteria,1UM1M@1239|Firmicutes,249J4@186801|Clostridia	186801|Clostridia	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_1427407_1	1249627.D779_0119	3.46e-77	240.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,1WW3U@135613|Chromatiales	135613|Chromatiales	T	PFAM PhoH family protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_1778242_1	1123399.AQVE01000002_gene2331	4.66e-68	215.0	COG1179@1|root,COG1179@2|Bacteria,1MWXR@1224|Proteobacteria,1RMT3@1236|Gammaproteobacteria,462SE@72273|Thiotrichales	72273|Thiotrichales	H	ThiF family	-	-	-	ko:K22132	-	-	-	-	ko00000,ko03016	-	-	-	ThiF
k59_1719727_1	323848.Nmul_A0241	5.65e-34	130.0	COG0760@1|root,COG0760@2|Bacteria,1R4EF@1224|Proteobacteria,2VK6Z@28216|Betaproteobacteria,371WN@32003|Nitrosomonadales	28216|Betaproteobacteria	O	TIGRFAM peptidyl-prolyl cis-trans isomerase, EpsD family	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase_2,SurA_N_3
k59_1543676_1	1215092.PA6_046_00220	8.89e-93	272.0	2DB76@1|root,2Z7JZ@2|Bacteria,1R41X@1224|Proteobacteria,1S1J8@1236|Gammaproteobacteria,1YIS6@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
k59_1543676_2	118166.JH976537_gene401	1.41e-132	396.0	COG3497@1|root,COG3497@2|Bacteria,1G41S@1117|Cyanobacteria,1H9RA@1150|Oscillatoriales	1117|Cyanobacteria	S	Phage tail sheath protein	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
k59_905962_2	1713.JOFV01000015_gene1776	1.17e-38	137.0	COG0363@1|root,COG0363@2|Bacteria,2GMQ2@201174|Actinobacteria,4F0XH@85016|Cellulomonadaceae	201174|Actinobacteria	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	pgl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:1901135,GO:1901360,GO:1901564	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
k59_663912_1	768671.ThimaDRAFT_3755	2.42e-24	100.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1WWHB@135613|Chromatiales	135613|Chromatiales	E	homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
k59_262149_1	237368.SCABRO_02407	2.23e-79	251.0	COG0269@1|root,COG0684@1|root,COG0269@2|Bacteria,COG0684@2|Bacteria,2J0G2@203682|Planctomycetes	203682|Planctomycetes	G	Orotidine 5'-phosphate decarboxylase / HUMPS family	-	-	4.1.2.43	ko:K08093	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338	RC00421,RC00422	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,RraA-like
k59_428483_1	1445613.JALM01000038_gene2968	1.17e-180	532.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4DY9U@85010|Pseudonocardiales	201174|Actinobacteria	C	aconitate hydratase	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_604438_1	1318628.MARLIPOL_12645	0.00097	41.6	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria,46A3P@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	COG1233 Phytoene dehydrogenase and related proteins	-	-	1.3.99.23	ko:K09516	ko00830,map00830	-	R07163	RC01835	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase,FAD_binding_6,NAD_binding_1,NAD_binding_8
k59_604438_2	522306.CAP2UW1_0958	3.31e-85	258.0	COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,2VHZD@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Phosphoribulokinase	cbbP	-	2.7.1.19	ko:K00855	ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200	M00165,M00166	R01523	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
k59_1845337_1	1209984.BN978_04824	3.02e-77	254.0	COG3497@1|root,COG3497@2|Bacteria,2GMJA@201174|Actinobacteria,2386C@1762|Mycobacteriaceae	201174|Actinobacteria	S	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
k59_1130768_1	1121918.ARWE01000001_gene3254	2.25e-86	266.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1719743_1	631362.Thi970DRAFT_04690	5.68e-136	394.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1WW0A@135613|Chromatiales	135613|Chromatiales	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_839724_2	926567.TheveDRAFT_0528	8.71e-38	134.0	COG1137@1|root,COG1137@2|Bacteria,3T9R8@508458|Synergistetes	508458|Synergistetes	S	ABC transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran
k59_1543698_1	471853.Bcav_0021	2.75e-33	116.0	2E4NY@1|root,32ZHR@2|Bacteria,2GQPW@201174|Actinobacteria	201174|Actinobacteria	D	involved in cell division	crgA	-	-	-	-	-	-	-	-	-	-	-	CrgA
k59_262176_1	1287276.X752_12010	2.05e-30	124.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2TRQG@28211|Alphaproteobacteria,43H8A@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
k59_663932_1	1125863.JAFN01000001_gene1966	3.25e-79	245.0	COG0823@1|root,COG0823@2|Bacteria,1QW3I@1224|Proteobacteria	1224|Proteobacteria	U	Beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40
k59_663935_1	935839.JAGJ01000007_gene3202	3.55e-117	351.0	COG0770@1|root,COG0770@2|Bacteria,2GK0Y@201174|Actinobacteria,4F3TR@85017|Promicromonosporaceae	201174|Actinobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_964939_1	519989.ECTPHS_01944	6.13e-46	159.0	COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,1RNPD@1236|Gammaproteobacteria,1WWH6@135613|Chromatiales	135613|Chromatiales	D	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity	zapD	-	-	ko:K18778	-	-	-	-	ko00000,ko03036	-	-	-	ZapD
k59_1662330_1	314278.NB231_07797	1.72e-130	418.0	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,1RMMF@1236|Gammaproteobacteria,1WWU1@135613|Chromatiales	135613|Chromatiales	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
k59_487288_1	55529.EKX39199	5.35e-05	52.0	2E5VT@1|root,2SCMT@2759|Eukaryota	2759|Eukaryota	S	Glycosyltransferase sugar-binding region containing DXD motif	-	-	-	-	-	-	-	-	-	-	-	-	Gly_transf_sug
k59_28306_1	1121405.dsmv_2891	7.79e-47	157.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,42TV9@68525|delta/epsilon subdivisions,2WNAN@28221|Deltaproteobacteria,2MK10@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_778044_1	1283287.KB822577_gene3117	1.36e-51	175.0	COG1940@1|root,COG1940@2|Bacteria,2GJ2S@201174|Actinobacteria,4DQ9A@85009|Propionibacteriales	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,MarR_2,ROK
k59_1081495_1	1283284.AZUK01000001_gene1762	1.66e-57	180.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1Y4JR@135624|Aeromonadales	135624|Aeromonadales	K	Belongs to the P(II) protein family	glnB	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
k59_377758_2	2340.JV46_18900	9.74e-37	127.0	COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,1S343@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Pfam Rhodanese-like	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_487296_1	471853.Bcav_2175	5.74e-117	354.0	COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0040007,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_1845382_2	1079986.JH164861_gene7206	6.01e-65	210.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria	201174|Actinobacteria	M	Capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
k59_1543724_2	1122599.AUGR01000006_gene3762	4.04e-41	145.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1XHES@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_1192474_1	1040987.AZUY01000021_gene1578	1.5e-49	180.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2TQYD@28211|Alphaproteobacteria,43IR1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	nasA	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_311295_1	367299.JOEE01000008_gene520	8.14e-72	223.0	COG1028@1|root,COG1028@2|Bacteria,2GKE1@201174|Actinobacteria,4FFWP@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_311295_2	1386969.AWTB01000090_gene2831	3.79e-10	58.5	COG2207@1|root,COG2207@2|Bacteria,2IFDE@201174|Actinobacteria,4GE75@85026|Gordoniaceae	201174|Actinobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
k59_722437_1	857087.Metme_0456	4.64e-143	431.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1XEJP@135618|Methylococcales	135618|Methylococcales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_1490323_1	521097.Coch_1815	9.25e-11	65.5	COG0500@1|root,COG2226@2|Bacteria,4NM1I@976|Bacteroidetes,1HZZ6@117743|Flavobacteriia,1ERDW@1016|Capnocytophaga	976|Bacteroidetes	Q	Methyltransferase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Ubie_methyltran
k59_194325_1	1386089.N865_20130	2.7e-143	415.0	COG1609@1|root,COG1609@2|Bacteria,2GJRG@201174|Actinobacteria,4FEKZ@85021|Intrasporangiaceae	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	malR	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	LacI,Peripla_BP_3
k59_487311_1	1121035.AUCH01000014_gene2375	1.22e-39	142.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,2VIB5@28216|Betaproteobacteria,2KV8E@206389|Rhodocyclales	206389|Rhodocyclales	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
k59_487311_2	267608.RSc1121	1.09e-30	118.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2VI55@28216|Betaproteobacteria,1JZMM@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_28342_1	367299.JOEE01000007_gene97	1.05e-177	510.0	COG1132@1|root,COG1132@2|Bacteria,2GJAP@201174|Actinobacteria,4FF0Q@85021|Intrasporangiaceae	201174|Actinobacteria	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
k59_28344_2	349124.Hhal_2413	2.91e-41	145.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1RQ2D@1236|Gammaproteobacteria,1WXUX@135613|Chromatiales	135613|Chromatiales	I	6-phosphogluconate dehydrogenase, NAD-binding	-	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_1490329_1	498211.CJA_1606	1.97e-29	114.0	COG1052@1|root,COG1052@2|Bacteria,1MVSS@1224|Proteobacteria,1RMWR@1236|Gammaproteobacteria,1FGPX@10|Cellvibrio	1236|Gammaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	ldhA	GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006067,GO:0006082,GO:0006083,GO:0006089,GO:0006090,GO:0006091,GO:0006103,GO:0006105,GO:0006113,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008720,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0015942,GO:0015980,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019318,GO:0019362,GO:0019637,GO:0019660,GO:0019664,GO:0019666,GO:0019693,GO:0019752,GO:0032787,GO:0034308,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0050896,GO:0051186,GO:0051287,GO:0055086,GO:0055114,GO:0070404,GO:0071704,GO:0072521,GO:0072524,GO:0097159,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901615	1.1.1.28	ko:K03778	ko00620,ko01120,map00620,map01120	-	R00704	RC00044	ko00000,ko00001,ko01000	-	-	iJN746.PP_1649,iPC815.YPO2329,iSFV_1184.SFV_1805,iSF_1195.SF1814,iSFxv_1172.SFxv_2031,iS_1188.S1459	2-Hacid_dh,2-Hacid_dh_C
k59_1490329_2	269799.Gmet_0936	1.92e-34	121.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,42U6P@68525|delta/epsilon subdivisions,2WQ00@28221|Deltaproteobacteria,43V75@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	SMART HNH nuclease	-	-	-	ko:K07451	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HNH_5
k59_1013033_1	438753.AZC_3721	6.37e-119	363.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2V96G@28211|Alphaproteobacteria,3F21X@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_28347_1	1121451.DESAM_10281	2.56e-24	99.4	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PGKI@1224|Proteobacteria,43A8X@68525|delta/epsilon subdivisions,2X26Q@28221|Deltaproteobacteria,2MFUF@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21
k59_663981_1	994573.T472_0207500	1.43e-55	182.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,36DZN@31979|Clostridiaceae	186801|Clostridia	L	Formamidopyrimidine-DNA glycosylase H2TH domain	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_604509_1	84531.JMTZ01000002_gene803	2.56e-74	239.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1X60A@135614|Xanthomonadales	135614|Xanthomonadales	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_906054_1	471853.Bcav_2780	2.08e-21	95.5	COG0477@1|root,COG2814@2|Bacteria,2GJK6@201174|Actinobacteria	201174|Actinobacteria	EGP	Drug resistance transporter, bcr cfla subfamily	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_906054_2	543632.JOJL01000022_gene806	1.36e-15	76.3	COG2197@1|root,COG2267@1|root,COG2197@2|Bacteria,COG2267@2|Bacteria,2GN4Z@201174|Actinobacteria,4DIP7@85008|Micromonosporales	201174|Actinobacteria	IKT	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,GerE
k59_722456_1	713586.KB900536_gene2727	9.6e-97	301.0	COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales	135613|Chromatiales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_1602039_1	981384.AEYW01000025_gene4038	1.62e-24	99.4	2EXGG@1|root,33QSQ@2|Bacteria,1NTX2@1224|Proteobacteria,2UQSN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_487330_1	207559.Dde_1185	6.68e-47	165.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42N16@68525|delta/epsilon subdivisions,2X73Y@28221|Deltaproteobacteria,2MBUH@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	dppA	-	-	ko:K02035,ko:K12368	ko02010,ko02024,ko02030,map02010,map02024,map02030	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1549098_1	519989.ECTPHS_10796	2.6e-09	54.3	COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,1SCTJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM Sulphur oxidation protein SoxZ	soxZ	-	-	ko:K17227	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxZ
k59_1549098_2	207954.MED92_13498	3.69e-59	193.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,1RS6A@1236|Gammaproteobacteria,1XJ4D@135619|Oceanospirillales	135619|Oceanospirillales	C	C-type monoheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the intermediary formation of conspicuous sulfur globules inside of the cells	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_610174_2	1049564.TevJSym_bc00270	6.74e-91	280.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,1J4GS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the thiolase family	pcaF	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_492907_1	983917.RGE_18280	2.26e-06	50.1	COG5652@1|root,COG5652@2|Bacteria,1NGE7@1224|Proteobacteria,2VYXF@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM VanZ	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
k59_492907_2	85643.Tmz1t_1765	9.67e-19	84.3	COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,2VNNH@28216|Betaproteobacteria,2KWH0@206389|Rhodocyclales	206389|Rhodocyclales	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
k59_1668078_2	298654.FraEuI1c_6680	2.37e-49	180.0	COG5002@1|root,COG5002@2|Bacteria,2I2DU@201174|Actinobacteria,4ESBG@85013|Frankiales	201174|Actinobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_1262596_1	521674.Plim_0953	1.21e-27	116.0	COG3568@1|root,COG3568@2|Bacteria,2IYP5@203682|Planctomycetes	203682|Planctomycetes	S	PFAM GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
k59_1088482_1	1120983.KB894576_gene3451	2.04e-11	65.1	COG2979@1|root,COG2979@2|Bacteria,1R95E@1224|Proteobacteria,2U3YT@28211|Alphaproteobacteria,1JP9R@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF533)	-	-	-	-	-	-	-	-	-	-	-	-	DUF533
k59_1783548_2	583355.Caka_2912	3.79e-60	199.0	COG3303@1|root,COG3303@2|Bacteria,46UP1@74201|Verrucomicrobia,3K7Z3@414999|Opitutae	414999|Opitutae	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C552
k59_1198198_1	765912.Thimo_2648	1.66e-110	325.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,1WXGF@135613|Chromatiales	135613|Chromatiales	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_1017817_1	489825.LYNGBM3L_66070	2.05e-70	240.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1H6ZY@1150|Oscillatoriales	1117|Cyanobacteria	Q	non-ribosomal peptide synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_11,Methyltransf_12,Methyltransf_25,Methyltransf_31,PP-binding
k59_1668087_1	864069.MicloDRAFT_00065700	2.61e-23	93.6	COG4461@1|root,COG4461@2|Bacteria,1R6Q3@1224|Proteobacteria,2U74M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Membrane-bound lysozyme-inhibitor of c-type lysozyme	-	-	-	-	-	-	-	-	-	-	-	-	LprI,MliC
k59_1198199_1	1033802.SSPSH_003279	6.1e-25	104.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_1198199_2	187272.Mlg_2392	4.73e-74	237.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1WXA3@135613|Chromatiales	135613|Chromatiales	U	General secretion pathway protein F	-	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
k59_1136225_1	312309.VF_A1107	1.05e-43	166.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,1XVNX@135623|Vibrionales	135623|Vibrionales	M	Small-conductance mechanosensitive channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel
k59_1497114_1	156889.Mmc1_0912	4.2e-05	45.4	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TS80@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1497114_2	156889.Mmc1_0519	1.7e-52	183.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TS80@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1607246_1	1089552.KI911559_gene2772	5.31e-38	130.0	COG0784@1|root,COG0784@2|Bacteria,1QU3I@1224|Proteobacteria,2TVXW@28211|Alphaproteobacteria,2JYY8@204441|Rhodospirillales	204441|Rhodospirillales	T	cheY-homologous receiver domain	-	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Hpt,PAS_8,Response_reg
k59_974044_1	717785.HYPMC_0380	5.38e-108	317.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2TR7F@28211|Alphaproteobacteria,3N61R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ABC transporter	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
k59_1854528_1	395493.BegalDRAFT_3295	3.34e-47	163.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1T1HN@1236|Gammaproteobacteria,461T8@72273|Thiotrichales	72273|Thiotrichales	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1668109_1	1265313.HRUBRA_01494	7.82e-86	264.0	COG1597@1|root,COG1597@2|Bacteria,1RB97@1224|Proteobacteria,1S4B3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	lipid kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Mmp37
k59_1198225_2	996637.SGM_5793	1.81e-68	218.0	COG0524@1|root,COG0524@2|Bacteria,2GKBG@201174|Actinobacteria	201174|Actinobacteria	G	Ribokinase	adoK	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_782949_1	1121422.AUMW01000013_gene1462	4.5e-98	293.0	COG0119@1|root,COG0119@2|Bacteria,1TQG3@1239|Firmicutes,24AUV@186801|Clostridia	186801|Clostridia	E	HMGL-like	mvaB	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
k59_974067_1	1283300.ATXB01000001_gene1749	6.63e-104	303.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria,1XDJM@135618|Methylococcales	135618|Methylococcales	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
k59_915045_1	1280950.HJO_02035	2.78e-69	220.0	COG1275@1|root,COG1275@2|Bacteria,1MXP2@1224|Proteobacteria,2TRB9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	C4-dicarboxylate transporter malic acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	SLAC1
k59_492947_1	768671.ThimaDRAFT_2365	7.98e-66	208.0	29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,1SBT1@1236|Gammaproteobacteria,1WYAZ@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4390)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4390
k59_492947_2	631362.Thi970DRAFT_00706	6.44e-47	169.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
k59_974074_1	765911.Thivi_3071	2.72e-120	370.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria,1WX2T@135613|Chromatiales	135613|Chromatiales	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	-	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_974077_2	1303692.SFUL_587	8.37e-66	218.0	COG0702@1|root,COG0702@2|Bacteria,2GIZA@201174|Actinobacteria	201174|Actinobacteria	GM	Nad-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
k59_669445_1	1123371.ATXH01000017_gene670	6.99e-54	188.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,2GGWQ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,dCache_1
k59_37862_1	1095769.CAHF01000010_gene1163	4.78e-86	272.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria,4728K@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Ferrous iron transport protein B C terminus	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_1198240_1	1238182.C882_1059	2.5e-37	141.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,2JPV0@204441|Rhodospirillales	204441|Rhodospirillales	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_141209_1	1125718.HMPREF1318_0093	1.54e-53	187.0	COG4988@1|root,COG4988@2|Bacteria,2I2DP@201174|Actinobacteria,4D4BC@85005|Actinomycetales	201174|Actinobacteria	V	Thiol reductant ABC exporter, CydD subunit	cydD	-	-	ko:K16013	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.129	-	-	ABC_membrane,ABC_tran
k59_434174_1	593907.Celgi_1599	2.41e-85	276.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4F0QU@85016|Cellulomonadaceae	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
k59_93281_1	114615.BRADO6523	4.74e-12	66.6	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,Trans_reg_C
k59_93281_2	1392498.JQLH01000001_gene2567	3.04e-22	92.8	COG2020@1|root,COG2020@2|Bacteria,4NJPI@976|Bacteroidetes,1I0SS@117743|Flavobacteriia,2PHZG@252356|Maribacter	976|Bacteroidetes	O	NnrU protein	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU
k59_727945_2	227882.SAV_7389	1.17e-09	59.3	COG0475@1|root,COG0475@2|Bacteria,2GJ69@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sodium hydrogen exchanger	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
k59_271282_1	1267533.KB906737_gene1632	4.51e-19	90.5	COG0433@1|root,COG0433@2|Bacteria,3Y69X@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial protein of unknown function (DUF853)	-	-	-	-	-	-	-	-	-	-	-	-	DUF853
k59_1262687_1	1394178.AWOO02000004_gene2401	1.62e-86	276.0	COG0376@1|root,COG0376@2|Bacteria,2GJFP@201174|Actinobacteria,4EFTF@85012|Streptosporangiales	201174|Actinobacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_915103_1	859657.RPSI07_mp0279	1.97e-14	73.9	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2VIAA@28216|Betaproteobacteria,1KGDX@119060|Burkholderiaceae	28216|Betaproteobacteria	M	HlyD family secretion protein	cyaD	-	-	ko:K02022,ko:K11003	ko03070,ko05133,map03070,map05133	M00325,M00575	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	8.A.1.3.1,8.A.1.3.2	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
k59_1326307_1	1123251.ATWM01000001_gene552	1.99e-25	107.0	COG1653@1|root,COG1653@2|Bacteria,2GJXB@201174|Actinobacteria,4FG1W@85021|Intrasporangiaceae	201174|Actinobacteria	G	Sugar ABC transporter substrate-binding protein	-	-	-	ko:K10232	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1,SBP_bac_8
k59_1326307_2	1894.JOER01000005_gene2681	1.08e-09	61.6	COG1175@1|root,COG1175@2|Bacteria,2GKJI@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025,ko:K17330	ko02010,map02010	M00207,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.33	-	-	BPD_transp_1
k59_1854617_1	1502852.FG94_03956	3.77e-97	293.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,2VK57@28216|Betaproteobacteria,472UA@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroF	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
k59_1725621_1	745014.OMB55_00014660	2.63e-15	75.9	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1J4IC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_1725621_2	868595.Desca_1450	3.59e-38	135.0	COG1692@1|root,COG1692@2|Bacteria,1TR9P@1239|Firmicutes,24967@186801|Clostridia,2604A@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM metallophosphoesterase, MG_246 BB_0505 family	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
k59_1198260_1	269799.Gmet_1669	1.45e-42	159.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42PWS@68525|delta/epsilon subdivisions,2WKI5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_974134_2	1249627.D779_1899	2.41e-10	62.0	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,1S08E@1236|Gammaproteobacteria,1WXTS@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_93313_1	382464.ABSI01000011_gene2678	8.36e-159	480.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,46TDM@74201|Verrucomicrobia,2ITXX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Putative amidoligase enzyme (DUF2126)	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
k59_1017875_1	948106.AWZT01000011_gene1996	1.52e-12	71.6	COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,2VQTE@28216|Betaproteobacteria,1K3KI@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphoglycerate mutase	gpmB	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
k59_93315_1	1121405.dsmv_2119	3.04e-55	191.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MIDR@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-3	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_93315_2	933262.AXAM01000137_gene3047	9.98e-35	126.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,42RIT@68525|delta/epsilon subdivisions,2WP64@28221|Deltaproteobacteria,2MJX0@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM peptidase M22 glycoprotease	yeaZ	-	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_1198263_1	367299.JOEE01000003_gene2675	5.85e-108	321.0	COG2355@1|root,COG2355@2|Bacteria,2GN82@201174|Actinobacteria,4FESZ@85021|Intrasporangiaceae	201174|Actinobacteria	E	Membrane dipeptidase	Dpep	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_845441_2	596154.Alide2_2727	6.55e-58	193.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2VHFX@28216|Betaproteobacteria,4AA4G@80864|Comamonadaceae	28216|Betaproteobacteria	J	RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
k59_1262709_1	1198232.CYCME_2197	1.51e-18	80.9	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S607@1236|Gammaproteobacteria,4613N@72273|Thiotrichales	72273|Thiotrichales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_386809_1	1121116.KB894766_gene366	3.52e-64	211.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2VH2H@28216|Betaproteobacteria,4ABB4@80864|Comamonadaceae	28216|Betaproteobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10,6.3.2.13	ko:K01929,ko:K15792	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R02788,R04573,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1607306_1	1049564.TevJSym_ac00350	2.29e-43	152.0	2EBH3@1|root,335HM@2|Bacteria,1NDXE@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1607306_2	1049564.TevJSym_ac00340	6.64e-48	159.0	2ER3M@1|root,33IP8@2|Bacteria,1NGAV@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1326341_1	1123065.ATWL01000002_gene1432	9.49e-29	120.0	COG4942@1|root,COG4942@2|Bacteria,2I64D@201174|Actinobacteria	201174|Actinobacteria	D	Peptidase family M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
k59_1088595_1	589865.DaAHT2_0959	0.00033	45.8	COG3852@1|root,COG3852@2|Bacteria,1QVPN@1224|Proteobacteria,42PS3@68525|delta/epsilon subdivisions,2X7MQ@28221|Deltaproteobacteria,2MHPZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_8
k59_493003_1	472759.Nhal_0092	3.64e-79	261.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWNH@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1136294_1	864051.BurJ1DRAFT_3799	2.12e-55	188.0	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,2W5VT@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Belongs to the GPAT DAPAT family	plsB	-	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_727976_1	768671.ThimaDRAFT_3540	1.33e-55	186.0	COG2143@1|root,COG2143@2|Bacteria,1RG25@1224|Proteobacteria,1S5HT@1236|Gammaproteobacteria,1X0QR@135613|Chromatiales	135613|Chromatiales	O	Thioredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
k59_727976_2	1286632.P278_00680	3.66e-74	229.0	COG5553@1|root,COG5553@2|Bacteria,4NJMB@976|Bacteroidetes,1I0CQ@117743|Flavobacteriia	976|Bacteroidetes	S	Cysteine dioxygenase type I	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_271332_1	1283300.ATXB01000001_gene2459	2.02e-64	201.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,1S3VN@1236|Gammaproteobacteria,1XF1U@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
k59_271332_2	690585.JNNU01000002_gene4989	6.71e-46	161.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2TRSV@28211|Alphaproteobacteria,4BBRM@82115|Rhizobiaceae	28211|Alphaproteobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
k59_1373260_1	1049564.TevJSym_ay00240	6.22e-136	400.0	COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,1RPDV@1236|Gammaproteobacteria,1J5GA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_38785_1	335543.Sfum_2387	2.98e-30	119.0	COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,42KZU@68525|delta/epsilon subdivisions,2WJ6T@28221|Deltaproteobacteria,2MSKS@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
k59_38785_2	335543.Sfum_0717	4.24e-23	95.1	COG1032@1|root,COG1032@2|Bacteria,1P9J0@1224|Proteobacteria,42MWG@68525|delta/epsilon subdivisions,2WIV5@28221|Deltaproteobacteria,2MQYP@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_1263404_2	1116375.VEJY3_16091	2.5e-06	48.5	COG3047@1|root,COG3047@2|Bacteria,1NUZJ@1224|Proteobacteria,1RRRC@1236|Gammaproteobacteria,1XSCD@135623|Vibrionales	135623|Vibrionales	M	Outer membrane protein W	ompW	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K07275	-	-	-	-	ko00000	-	-	-	OmpW
k59_317906_1	1379270.AUXF01000004_gene3264	2.46e-19	85.5	COG0526@1|root,COG0526@2|Bacteria,1ZTMM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Glutathione peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_1607934_1	640081.Dsui_3135	6.15e-36	137.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,2KUKU@206389|Rhodocyclales	206389|Rhodocyclales	O	HflC and HflK could encode or regulate a protease	-	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
k59_916367_1	1121937.AUHJ01000003_gene3189	5.53e-84	276.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464AK@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_846121_1	1036674.A28LD_2239	2.61e-08	61.6	COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,2QFDI@267893|Idiomarinaceae	1236|Gammaproteobacteria	M	TonB-dependent Receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_670140_1	118173.KB235914_gene2659	1.95e-66	212.0	29K36@1|root,3070J@2|Bacteria,1G63U@1117|Cyanobacteria,1HGII@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1263408_1	572477.Alvin_0834	4.42e-94	285.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1WWTF@135613|Chromatiales	135613|Chromatiales	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
k59_94550_2	1305735.JAFT01000004_gene235	2.92e-09	57.8	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,2PCFH@252301|Oceanicola	28211|Alphaproteobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_38792_1	42256.RradSPS_2597	2.96e-247	702.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4CPA7@84995|Rubrobacteria	84995|Rubrobacteria	P	heavy metal translocating P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
k59_1327666_1	526227.Mesil_0745	5.24e-67	213.0	COG0010@1|root,COG0010@2|Bacteria,1WIEY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the arginase family	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
k59_1379034_1	1157943.KB892705_gene902	6.25e-43	155.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria,235I1@1762|Mycobacteriaceae	201174|Actinobacteria	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1864868_1	1120956.JHZK01000011_gene1280	1e-117	347.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TQYV@28211|Alphaproteobacteria,1JMZ4@119043|Rhodobiaceae	28211|Alphaproteobacteria	IQ	Beta-ketoacyl synthase, C-terminal domain	fabB	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1554925_1	981369.JQMJ01000004_gene2413	5.42e-46	163.0	COG0232@1|root,COG0232@2|Bacteria,2GJ8F@201174|Actinobacteria,2NHHK@228398|Streptacidiphilus	201174|Actinobacteria	F	Phosphohydrolase-associated domain	dgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_147189_1	367299.JOEE01000004_gene1019	3.78e-90	265.0	COG0346@1|root,COG0346@2|Bacteria,2IIPR@201174|Actinobacteria,4FGBB@85021|Intrasporangiaceae	201174|Actinobacteria	E	methylmalonyl-CoA epimerase	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
k59_147189_2	1210046.B277_14513	3.21e-13	68.2	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4FE3A@85021|Intrasporangiaceae	201174|Actinobacteria	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	fadA4	GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0044464,GO:0046395,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:0075136,GO:1901575	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_675487_3	566466.NOR53_1860	6.69e-06	50.4	COG0607@1|root,COG0607@2|Bacteria,1NGN9@1224|Proteobacteria,1SIKU@1236|Gammaproteobacteria,1J77D@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4395,Rhodanese
k59_851151_1	1249627.D779_3020	2.11e-85	274.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria,1WX2T@135613|Chromatiales	135613|Chromatiales	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	-	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_45775_1	1049564.TevJSym_as00710	2.07e-129	380.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1J5GP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008883,GO:0009058,GO:0009064,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_1375,iECSF_1327.ECSF_1186,iUTI89_1310.UTI89_C1404	GlutR_N,GlutR_dimer,Shikimate_DH
k59_323043_1	717605.Theco_1454	9.43e-11	62.8	COG0561@1|root,COG0561@2|Bacteria,1TR16@1239|Firmicutes,4HCZ6@91061|Bacilli,274MN@186822|Paenibacillaceae	91061|Bacilli	S	Sucrose-6F-phosphate phosphohydrolase	ycsE	-	3.1.3.104	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R07280	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Hydrolase_3
k59_984408_1	1125863.JAFN01000001_gene1218	1.59e-68	229.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_787825_1	1163617.SCD_n02256	3.39e-98	293.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,2VQVG@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Methyltransferase type 11	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
k59_675492_1	870187.Thini_2719	7.06e-180	528.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1RQK9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	ttrA	-	1.8.5.5,1.8.5.6	ko:K08352,ko:K08357,ko:K21307	ko00920,ko01100,ko01120,ko02020,map00920,map01100,map01120,map02020	-	R10149,R10150,R11487	RC00168,RC02823,RC03109	ko00000,ko00001,ko01000,ko02000	5.A.3.10,5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_1864900_1	243231.GSU2318	1.04e-75	238.0	COG2230@1|root,COG2230@2|Bacteria,1MUW5@1224|Proteobacteria,42PIN@68525|delta/epsilon subdivisions,2WM1U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_616041_1	1049564.TevJSym_aq00810	3.69e-15	76.3	COG0674@1|root,COG1013@1|root,COG1144@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1144@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	forE	-	1.2.7.1	ko:K00171,ko:K00172,ko:K02573,ko:K03737,ko:K13795,ko:K18930	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,Fer4,Fer4_4,Fer4_6,Fer4_9,Nitroreductase,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_616041_2	1049564.TevJSym_aq00710	4.61e-34	129.0	COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1J4YP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_17,RnfC_N,SLBB
k59_1094838_1	471853.Bcav_1156	4.59e-50	172.0	COG4191@1|root,COG4191@2|Bacteria,2I2J2@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_1094838_2	1123065.ATWL01000023_gene3582	1.32e-16	75.5	COG2246@1|root,COG2246@2|Bacteria,2IFFV@201174|Actinobacteria	201174|Actinobacteria	S	PFAM GtrA family protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
k59_1613155_1	471853.Bcav_2929	2.91e-43	153.0	COG0624@1|root,COG0624@2|Bacteria,2GK09@201174|Actinobacteria	201174|Actinobacteria	E	succinyl-diaminopimelate desuccinylase	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1613155_2	471853.Bcav_2932	6.85e-65	212.0	COG1249@1|root,COG1249@2|Bacteria,2GMP7@201174|Actinobacteria	201174|Actinobacteria	C	Catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone	lpdA	GO:0000166,GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016651,GO:0016655,GO:0036094,GO:0043167,GO:0043168,GO:0044419,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051704,GO:0055114,GO:0070401,GO:0097159,GO:1901265,GO:1901363	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_851167_1	380358.XALC_0347	1.5e-142	423.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1X36F@135614|Xanthomonadales	135614|Xanthomonadales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_1674046_1	316067.Geob_1122	4.34e-44	155.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42MHH@68525|delta/epsilon subdivisions,2WIMW@28221|Deltaproteobacteria,43RZ9@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iAF987.Gmet_0204	Aminotran_3
k59_396923_1	264198.Reut_B5043	8.07e-31	125.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,1K1KS@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	ko:K14978	ko02020,map02020	M00663	-	-	ko00000,ko00001,ko00002,ko01001,ko02022	-	-	-	CHASE,HAMP,HATPase_c,HisKA,Hpt,MHYT,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
k59_1022729_1	862517.HMPREF9225_0748	1.6e-32	122.0	COG2077@1|root,COG2077@2|Bacteria,1V474@1239|Firmicutes,24HUY@186801|Clostridia,22HDB@1570339|Peptoniphilaceae	186801|Clostridia	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	tpx	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA,Redoxin
k59_675525_1	383372.Rcas_1004	8.82e-65	208.0	COG0379@1|root,COG0379@2|Bacteria,2G64Y@200795|Chloroflexi,375TJ@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
k59_675525_2	1379270.AUXF01000003_gene3584	1.04e-27	112.0	COG3653@1|root,COG3653@2|Bacteria,1ZTDH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
k59_147234_1	631362.Thi970DRAFT_01712	2.91e-75	239.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,1RMQC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_787852_1	880072.Desac_1681	6e-89	269.0	COG0223@1|root,COG0223@2|Bacteria,1MW07@1224|Proteobacteria	1224|Proteobacteria	J	Methionyl-tRNA formyltransferase	-	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_1731460_1	408672.NBCG_04175	1.15e-118	347.0	COG2113@1|root,COG2113@2|Bacteria,2GP39@201174|Actinobacteria,4DN5Y@85009|Propionibacteriales	201174|Actinobacteria	E	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K02002	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
k59_926455_2	104623.Ser39006_00915	2.7e-20	89.0	2DMTH@1|root,32TKP@2|Bacteria,1N4TE@1224|Proteobacteria,1S9K6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_558084_2	58123.JOFJ01000001_gene3224	2.95e-12	72.0	COG0477@1|root,COG2814@2|Bacteria,2H4H5@201174|Actinobacteria,4ER31@85012|Streptosporangiales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	ko:K05557	-	-	-	-	ko00000,ko02000	2.A.1.3.7	-	-	MFS_1
k59_46659_1	589865.DaAHT2_1337	8.18e-71	234.0	COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,42NCP@68525|delta/epsilon subdivisions,2WJSM@28221|Deltaproteobacteria,2MI5K@213118|Desulfobacterales	28221|Deltaproteobacteria	M	HAD-superfamily hydrolase, subfamily IIB	-	-	2.4.1.14	ko:K00696	ko00500,ko01100,map00500,map01100	-	R00766	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth
k59_1866042_1	1249627.D779_0048	3.25e-84	268.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPES@1236|Gammaproteobacteria,1WWEX@135613|Chromatiales	135613|Chromatiales	S	PFAM ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_1269903_2	1304865.JAGF01000001_gene1006	2.82e-47	158.0	COG4315@1|root,COG4315@2|Bacteria,2GNDV@201174|Actinobacteria	201174|Actinobacteria	S	Secreted repeat of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
k59_323737_1	1394178.AWOO02000026_gene5097	1.39e-18	86.7	COG2091@1|root,COG2091@2|Bacteria,2IQ65@201174|Actinobacteria,4EK4V@85012|Streptosporangiales	201174|Actinobacteria	H	4'-phosphopantetheinyl transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
k59_46663_1	471853.Bcav_0899	7.67e-08	55.1	COG1112@1|root,COG1112@2|Bacteria,2GKJW@201174|Actinobacteria	201174|Actinobacteria	L	Superfamily I DNA and RNA helicases and helicase subunits	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DUF4011
k59_46663_2	84531.JMTZ01000019_gene3986	1.05e-14	73.6	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria,1X701@135614|Xanthomonadales	135614|Xanthomonadales	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
k59_46663_3	471853.Bcav_0901	3.48e-28	111.0	COG3745@1|root,COG3745@2|Bacteria	2|Bacteria	U	Flp pilus assembly protein CpaB	cpaB	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	ChapFlgA,RcpC,SAF
k59_676210_1	946483.Cenrod_0637	3.97e-18	88.6	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,4A9K5@80864|Comamonadaceae	28216|Betaproteobacteria	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
k59_440868_1	1304865.JAGF01000001_gene3299	2.47e-59	189.0	COG5401@1|root,COG5401@2|Bacteria,2IQ3Y@201174|Actinobacteria	201174|Actinobacteria	S	Immunoglobulin-like domain of bacterial spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad2
k59_323738_1	929556.Solca_0050	8.11e-15	79.0	COG1470@1|root,COG3209@1|root,COG4932@1|root,COG1470@2|Bacteria,COG3209@2|Bacteria,COG4932@2|Bacteria,4PKBQ@976|Bacteroidetes,1J0N1@117747|Sphingobacteriia	976|Bacteroidetes	M	conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Calx-beta,DUF11,SprB
k59_1269915_2	153496.JNAB01000004_gene933	2.12e-11	60.8	COG0507@1|root,COG0507@2|Bacteria,1MUTR@1224|Proteobacteria,2TSQQ@28211|Alphaproteobacteria,2JXIT@204441|Rhodospirillales	204441|Rhodospirillales	L	MobA/MobL family	-	-	-	-	-	-	-	-	-	-	-	-	MobA_MobL
k59_1866067_1	768671.ThimaDRAFT_3695	1.81e-73	227.0	COG2863@1|root,COG2863@2|Bacteria,1RBXV@1224|Proteobacteria,1SEAS@1236|Gammaproteobacteria,1X1G7@135613|Chromatiales	135613|Chromatiales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_1379802_1	246196.MSMEI_0429	6.2e-26	106.0	COG0511@1|root,COG0511@2|Bacteria,2GMCA@201174|Actinobacteria,238PR@1762|Mycobacteriaceae	201174|Actinobacteria	I	MDMPI C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
k59_1337797_1	521393.JH806633_gene1722	8.98e-34	129.0	COG0452@1|root,COG0452@2|Bacteria,2GJGJ@201174|Actinobacteria,4D33I@85005|Actinomycetales	201174|Actinobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k59_1337797_2	1193181.BN10_980002	2.66e-17	80.5	COG0192@1|root,COG0192@2|Bacteria,2GJ4U@201174|Actinobacteria,4FF9B@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_1269925_1	987059.RBXJA2T_17771	4.58e-127	374.0	COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,2VH4M@28216|Betaproteobacteria,1KJNU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	purT	-	2.1.2.2	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp,Epimerase
k59_398090_1	396588.Tgr7_1594	3.31e-215	602.0	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,1RMGK@1236|Gammaproteobacteria,1WWHA@135613|Chromatiales	135613|Chromatiales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1095634_1	1306174.JODP01000001_gene4632	1.69e-65	211.0	COG1300@1|root,COG1300@2|Bacteria,2GJTG@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIM
k59_1674801_1	679926.Mpet_1989	3.58e-13	68.9	COG2236@1|root,arCOG00040@2157|Archaea,2XYCC@28890|Euryarchaeota,2NBH5@224756|Methanomicrobia	224756|Methanomicrobia	F	Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	iAF692.Mbar_A3178	Pribosyltran
k59_1674801_2	572477.Alvin_1317	4.18e-06	47.4	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1SYHR@1236|Gammaproteobacteria,1WZZ5@135613|Chromatiales	135613|Chromatiales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_926510_1	1331060.RLDS_11430	5.41e-128	373.0	2ETRR@1|root,33M97@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1613876_1	1249627.D779_3185	3.06e-32	117.0	COG4634@1|root,COG4634@2|Bacteria,1RH7A@1224|Proteobacteria,1SBJT@1236|Gammaproteobacteria,1X1A3@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_104571_1	658187.LDG_8067	2.36e-15	77.0	COG0654@1|root,COG0654@2|Bacteria,1R7UC@1224|Proteobacteria,1S1B9@1236|Gammaproteobacteria,1JDK8@118969|Legionellales	118969|Legionellales	CH	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid	kmo	-	1.14.13.9	ko:K00486	ko00380,ko01100,map00380,map01100	M00038	R01960	RC00046	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_104571_2	1121013.P873_00710	7.31e-60	196.0	COG3844@1|root,COG3844@2|Bacteria,1MUKN@1224|Proteobacteria,1RPY3@1236|Gammaproteobacteria,1X3FQ@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016822,GO:0016823,GO:0019439,GO:0019441,GO:0019752,GO:0030429,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
k59_1023315_1	713586.KB900536_gene2551	1.43e-21	98.2	COG1538@1|root,COG1538@2|Bacteria,1RDNB@1224|Proteobacteria,1S535@1236|Gammaproteobacteria,1WXQ5@135613|Chromatiales	135613|Chromatiales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_926519_2	1304865.JAGF01000001_gene2443	1.55e-51	172.0	COG0680@1|root,COG0680@2|Bacteria	2|Bacteria	C	spore germination	hoxW	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
k59_926519_3	1304865.JAGF01000001_gene2442	2.75e-149	432.0	COG3259@1|root,COG3259@2|Bacteria,2GQ33@201174|Actinobacteria	201174|Actinobacteria	C	PFAM Nickel-dependent hydrogenase, large subunit	hoxH	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
k59_1269948_1	99598.Cal7507_4739	1.42e-34	136.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1G0AZ@1117|Cyanobacteria,1HMXP@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_440906_1	443143.GM18_3083	2.94e-10	65.5	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42MNA@68525|delta/epsilon subdivisions,2WK7Z@28221|Deltaproteobacteria,43U31@69541|Desulfuromonadales	28221|Deltaproteobacteria	OU	TIGRFAM signal peptide peptidase SppA, 36K type	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_1866124_1	983545.Glaag_3916	5.65e-62	201.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,465BH@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	COG1131 ABC-type multidrug transport system, ATPase component	yadG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1337851_1	998674.ATTE01000001_gene1723	8.93e-68	224.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,45ZSE@72273|Thiotrichales	72273|Thiotrichales	C	dihydrolipoamide dehydrogenase	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
k59_279683_1	246196.MSMEI_1056	1.12e-13	73.6	COG0154@1|root,COG0154@2|Bacteria,2GN7F@201174|Actinobacteria,235ME@1762|Mycobacteriaceae	201174|Actinobacteria	J	COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_147965_1	1196323.ALKF01000197_gene2264	8.66e-18	84.7	COG4191@1|root,COG4191@2|Bacteria,1VCNJ@1239|Firmicutes,4HVBX@91061|Bacilli,26Q9Z@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	2.7.13.3	ko:K02491	ko02020,map02020	M00485	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,MEDS,PAS,PAS_8,PAS_9
k59_147965_2	879212.DespoDRAFT_01333	1.55e-26	108.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIB8@213118|Desulfobacterales	28221|Deltaproteobacteria	T	response regulator receiver	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1269968_1	1500304.JQKY01000004_gene1689	1.22e-48	163.0	COG3807@1|root,COG3807@2|Bacteria,1RHM2@1224|Proteobacteria,2UA1R@28211|Alphaproteobacteria,4B7Y7@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	MA20_24010	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	SH3_4
k59_398163_1	649743.HMPREF0972_01751	6.37e-97	290.0	COG2171@1|root,COG2171@2|Bacteria,2GIZ9@201174|Actinobacteria,4D4JJ@85005|Actinomycetales	201174|Actinobacteria	E	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA	dapD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008666,GO:0016020,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0030312,GO:0031402,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0071944	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1201c	Hexapep_2,THDPS_M
k59_104632_1	670307.HYPDE_39003	2.03e-23	99.4	COG4547@1|root,COG4547@2|Bacteria,1MX11@1224|Proteobacteria,2TS4N@28211|Alphaproteobacteria,3N691@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	cobalt chelatase	cobT	-	6.6.1.2	ko:K09883	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	CobT,CobT_C
k59_1866155_1	289377.HL41_05015	4.04e-13	66.6	COG1758@1|root,COG1758@2|Bacteria,2GHZJ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
k59_46771_1	402777.KB235903_gene660	3.3e-39	144.0	COG2192@1|root,COG2192@2|Bacteria,1G1FV@1117|Cyanobacteria,1H9E9@1150|Oscillatoriales	1117|Cyanobacteria	O	carbamoyl transferase, NodU family	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
k59_46771_2	998674.ATTE01000001_gene3667	8.89e-35	124.0	COG2192@1|root,COG2192@2|Bacteria,1R3MX@1224|Proteobacteria,1T69R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	nodulation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_46771_3	998674.ATTE01000001_gene3668	1.01e-19	80.1	2EGPU@1|root,33AFZ@2|Bacteria,1NH69@1224|Proteobacteria,1SHN2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1141916_1	261292.Nit79A3_0026	1.85e-190	592.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2VKDG@28216|Betaproteobacteria,371PE@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
k59_1732217_2	1123065.ATWL01000002_gene1701	7.8e-29	110.0	COG0289@1|root,COG0289@2|Bacteria,2GM2T@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
k59_1866163_1	290400.Jann_3395	1.02e-49	172.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Zn-dependent dipeptidase, microsomal dipeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M19
k59_398171_2	1205910.B005_5390	1.42e-12	71.2	COG0572@1|root,COG0572@2|Bacteria,2GTAB@201174|Actinobacteria	201174|Actinobacteria	F	uridine kinase	pabB	-	-	-	-	-	-	-	-	-	-	-	-
k59_1740076_2	396588.Tgr7_1653	2.59e-07	52.4	COG4382@1|root,COG4382@2|Bacteria,1N7CA@1224|Proteobacteria,1SECS@1236|Gammaproteobacteria,1X1RP@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1018)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1018
k59_290292_1	1185652.USDA257_c60040	3.12e-46	155.0	COG5588@1|root,COG5588@2|Bacteria,1PZHC@1224|Proteobacteria,2TVVV@28211|Alphaproteobacteria,4BBPN@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1326
k59_57655_1	589865.DaAHT2_0631	3.6e-91	280.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42N78@68525|delta/epsilon subdivisions,2WM0M@28221|Deltaproteobacteria,2MHVS@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	mscS-2	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_1212144_1	765910.MARPU_00280	4.67e-80	253.0	COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,1RMAV@1236|Gammaproteobacteria,1WZAK@135613|Chromatiales	135613|Chromatiales	U	Involved in arsenical resistance. Thought to form the channel of an arsenite pump	arsB	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB
k59_1512895_1	795666.MW7_0424	4.11e-65	208.0	COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,2VHD7@28216|Betaproteobacteria,1K3VC@119060|Burkholderiaceae	28216|Betaproteobacteria	O	PFAM 20S proteasome, A and B subunits	-	-	-	ko:K07395	-	-	-	-	ko00000	-	-	-	Proteasome
k59_1104259_1	83344.XP_007920653.1	1.32e-17	87.4	COG1355@1|root,KOG3086@2759|Eukaryota,38CEC@33154|Opisthokonta,3NUR4@4751|Fungi,3QP2P@4890|Ascomycota,1ZYZT@147541|Dothideomycetes,3MGGW@451867|Dothideomycetidae	4751|Fungi	S	Memo-like protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0008150,GO:0032886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
k59_409952_1	1294273.roselon_00384	1.1e-40	160.0	COG0664@1|root,COG1752@1|root,COG0664@2|Bacteria,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2TVQR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin,cNMP_binding
k59_938077_1	367299.JOEE01000003_gene2928	1.14e-76	242.0	COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4FEF5@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Belongs to the long-chain O-acyltransferase family	tgs3	GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
k59_938077_2	1122611.KB903959_gene4227	9.2e-29	110.0	COG0730@1|root,COG0730@2|Bacteria,2II68@201174|Actinobacteria,4EKNN@85012|Streptosporangiales	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_1278734_1	1121405.dsmv_2717	3.04e-75	248.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2MHW3@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1031308_1	1380354.JIAN01000010_gene3038	1.84e-132	383.0	COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria,4F1QP@85016|Cellulomonadaceae	201174|Actinobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
k59_794681_1	95619.PM1_0208055	1.73e-40	139.0	COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
k59_794681_2	506534.Rhein_0453	6.36e-60	205.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales	135613|Chromatiales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_1104274_1	497965.Cyan7822_2564	1.68e-43	154.0	COG1597@1|root,COG1597@2|Bacteria,1GMKF@1117|Cyanobacteria,3KKI7@43988|Cyanothece	1117|Cyanobacteria	I	lipid kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_409968_1	1408428.JNJP01000043_gene2844	2.32e-38	138.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,42UBZ@68525|delta/epsilon subdivisions,2WQ0E@28221|Deltaproteobacteria,2MA0Q@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Belongs to the SUA5 family	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
k59_214348_1	263358.VAB18032_19950	5.19e-98	293.0	COG0627@1|root,COG0627@2|Bacteria,2GJX4@201174|Actinobacteria,4D9HJ@85008|Micromonosporales	201174|Actinobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_1796104_2	1142394.PSMK_24370	1.15e-25	107.0	COG3437@1|root,COG3437@2|Bacteria,2IXR5@203682|Planctomycetes	203682|Planctomycetes	T	metal-dependent phosphohydrolase HD sub domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Pkinase,Response_reg
k59_684312_1	1286171.EAL2_c02080	1.53e-35	135.0	COG0773@1|root,COG0773@2|Bacteria,1TQ5H@1239|Firmicutes,2484K@186801|Clostridia,25UQR@186806|Eubacteriaceae	186801|Clostridia	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_409997_1	1713.JOFV01000001_gene2083	8.03e-56	196.0	COG2366@1|root,COG2366@2|Bacteria,2GISQ@201174|Actinobacteria,4F0SH@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_1031346_1	338966.Ppro_3532	1.55e-84	265.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,43CGQ@68525|delta/epsilon subdivisions,2X7RV@28221|Deltaproteobacteria	1224|Proteobacteria	C	PFAM NADH Ubiquinone plastoquinone (complex I)	hyfD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	1.6.5.3	ko:K00341,ko:K05568,ko:K12139,ko:K14086	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	iEcSMS35_1347.EcSMS35_2631	Proton_antipo_M,Proton_antipo_N
k59_1512947_1	66269.NL54_07195	1.1e-30	123.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,3VY1R@53335|Pantoea	1236|Gammaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_1796122_1	477228.YO5_10255	2.53e-21	90.9	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1YZX0@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008840,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_2492,iJN746.PP_1237,iYL1228.KPN_02812	DHDPS
k59_997387_1	682795.AciX8_2532	5.88e-60	207.0	COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,3Y3X7@57723|Acidobacteria,2JKGZ@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycosyltransferase family 20	-	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
k59_938140_1	485915.Dret_2002	4.12e-141	411.0	COG3464@1|root,COG3464@2|Bacteria,1R4DH@1224|Proteobacteria,43AQ4@68525|delta/epsilon subdivisions,2X63W@28221|Deltaproteobacteria,2MGXP@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM transposase IS204 IS1001 IS1096 IS1165 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,zf-ISL3
k59_566011_1	754476.Q7A_878	4.55e-57	191.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,45ZPH@72273|Thiotrichales	72273|Thiotrichales	H	PFAM aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1447427_1	526222.Desal_2398	4.24e-68	224.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,2M9EY@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_859424_1	768671.ThimaDRAFT_0168	1.32e-108	338.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1WWSC@135613|Chromatiales	135613|Chromatiales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1387706_1	870187.Thini_3153	1.28e-53	176.0	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,460ST@72273|Thiotrichales	72273|Thiotrichales	C	PFAM cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_1387706_2	1177181.T9A_01183	3.21e-55	179.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,1XJCE@135619|Oceanospirillales	135619|Oceanospirillales	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
k59_57799_1	1249627.D779_4110	2.18e-31	118.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1WXDA@135613|Chromatiales	135613|Chromatiales	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
k59_57799_2	631362.Thi970DRAFT_02521	7.29e-83	259.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1WVZB@135613|Chromatiales	135613|Chromatiales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_290432_1	96561.Dole_2497	9.82e-12	68.6	COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,42Q4U@68525|delta/epsilon subdivisions,2WJ08@28221|Deltaproteobacteria,2MI4K@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1278808_2	56780.SYN_03211	5e-32	119.0	COG3415@1|root,COG3415@2|Bacteria,1QVAE@1224|Proteobacteria,42ZPH@68525|delta/epsilon subdivisions,2WUTN@28221|Deltaproteobacteria,2MRJW@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	leucine-zipper of insertion element IS481	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
k59_743016_1	1121448.DGI_3137	3.26e-14	73.9	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42MAQ@68525|delta/epsilon subdivisions,2WKK0@28221|Deltaproteobacteria,2M91J@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iAF987.Gmet_1821	BPD_transp_2
k59_743016_2	316067.Geob_2800	1.84e-38	136.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42MKP@68525|delta/epsilon subdivisions,2WJU9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1740179_1	1123355.JHYO01000017_gene3608	1.76e-75	235.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,2TTDW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Thiosulfate-oxidizing multienzyme system protein SoxA	soxA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005623,GO:0006091,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009055,GO:0009987,GO:0016491,GO:0016667,GO:0016669,GO:0016740,GO:0016782,GO:0016783,GO:0018192,GO:0018193,GO:0018198,GO:0018307,GO:0019417,GO:0019418,GO:0019538,GO:0020037,GO:0022900,GO:0032991,GO:0036211,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0046982,GO:0046983,GO:0048037,GO:0055114,GO:0070069,GO:0071704,GO:0097159,GO:0098822,GO:1901363,GO:1901564	-	ko:K17222	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	-
k59_1682448_1	95619.PM1_0220790	1.62e-08	55.1	COG4266@1|root,COG4266@2|Bacteria,1MXJK@1224|Proteobacteria,1RR90@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the allantoicase family	alc	GO:0003674,GO:0003824,GO:0004037,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.3.4	ko:K01477	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02422	RC00379,RC00712	ko00000,ko00001,ko00002,ko01000	-	-	-	Allantoicase
k59_1682448_2	399795.CtesDRAFT_PD1260	4.01e-34	124.0	COG3194@1|root,COG3194@2|Bacteria,1RH5G@1224|Proteobacteria,2VT31@28216|Betaproteobacteria,4AF02@80864|Comamonadaceae	28216|Betaproteobacteria	F	Ureidoglycolate lyase	allA	-	4.3.2.3	ko:K01483	ko00230,ko01100,map00230,map01100	-	R00776	RC00153,RC00379	ko00000,ko00001,ko01000	-	-	-	Ureidogly_lyase
k59_410056_1	936136.ARRT01000002_gene693	6.07e-129	374.0	COG3391@1|root,COG3391@2|Bacteria,1MXDX@1224|Proteobacteria,2TQRB@28211|Alphaproteobacteria,4BNZU@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	56kDa selenium binding protein (SBP56)	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
k59_1563494_1	931627.MycrhDRAFT_0834	2.83e-60	194.0	COG3588@1|root,COG3588@2|Bacteria,2GN1A@201174|Actinobacteria,233KA@1762|Mycobacteriaceae	201174|Actinobacteria	G	Aldolase	fda	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
k59_566027_1	391937.NA2_19356	2.49e-12	69.3	COG1680@1|root,COG1680@2|Bacteria,1MVZN@1224|Proteobacteria,2VD02@28211|Alphaproteobacteria,43IMI@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
k59_1796150_1	1198232.CYCME_0104	1.08e-70	238.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,46225@72273|Thiotrichales	72273|Thiotrichales	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_859434_1	926550.CLDAP_09130	3.36e-20	87.8	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
k59_1621688_1	1121013.P873_12400	5.49e-206	600.0	COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria,1X7FN@135614|Xanthomonadales	135614|Xanthomonadales	HJ	Prokaryotic glutathione synthetase, ATP-grasp domain	-	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Mur_ligase_C,Mur_ligase_M,RimK
k59_1104344_1	393595.ABO_2023	1.62e-92	276.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1RMIZ@1236|Gammaproteobacteria,1XH7Z@135619|Oceanospirillales	135619|Oceanospirillales	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	Crp,HTH_Crp_2,cNMP_binding
k59_1104344_2	1026882.MAMP_02504	1.06e-33	121.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,4605S@72273|Thiotrichales	72273|Thiotrichales	EH	Glutamine amidotransferase of anthranilate synthase	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_997432_1	768671.ThimaDRAFT_1714	4.55e-140	407.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,1RQ65@1236|Gammaproteobacteria,1WWT1@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM FeS assembly protein SufB	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_624645_1	1049564.TevJSym_ao00280	2.87e-216	633.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1224|Proteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_997433_1	1267005.KB911255_gene2916	5.76e-115	357.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,3N65A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1740188_1	1049564.TevJSym_bb00050	2.27e-41	151.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_1740188_2	1049564.TevJSym_bb00040	8.11e-79	242.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,1RZ7Y@1236|Gammaproteobacteria,1J5GQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_566037_1	1265505.ATUG01000002_gene2655	1.64e-84	279.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_860595_2	572477.Alvin_1669	1.79e-19	87.4	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,1WVX4@135613|Chromatiales	135613|Chromatiales	I	TIGRFAM acetyl-CoA carboxylase, biotin carboxylase	-	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_1032703_1	1408418.JNJH01000087_gene1528	2.54e-73	242.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,2TRW4@28211|Alphaproteobacteria,2JPEM@204441|Rhodospirillales	204441|Rhodospirillales	S	Uncharacterized protein conserved in bacteria (DUF2309)	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k59_1741464_1	1283300.ATXB01000001_gene807	3.79e-25	108.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1XDNX@135618|Methylococcales	135618|Methylococcales	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
k59_567228_2	983545.Glaag_1975	4.93e-14	70.5	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RN4D@1236|Gammaproteobacteria,465K6@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	alcohol dehydrogenase	yjgB	GO:0003674,GO:0003824,GO:0004033,GO:0005488,GO:0008106,GO:0008150,GO:0008152,GO:0008270,GO:0016491,GO:0016614,GO:0016616,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114	-	ko:K12957	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1032718_1	28229.ND2E_3902	3.38e-87	271.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	-	-	1.1.3.8	ko:K00103	ko00053,ko01100,map00053,map01100	M00129	R00647,R03184,R10053	RC00195,RC00346,RC00869	ko00000,ko00001,ko00002,ko01000	-	-	-	ALO,FAD_binding_4
k59_1280145_1	648757.Rvan_0902	1.81e-122	361.0	COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,2TRP0@28211|Alphaproteobacteria,3N9FH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Transglycosylase SLT domain	mltB	-	-	ko:K00786,ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	PG_binding_1,SLT_2
k59_1622803_1	471853.Bcav_0032	2.35e-71	221.0	COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria	201174|Actinobacteria	T	(FHA) domain	fhaA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA,Yop-YscD_cpl
k59_449999_1	367299.JOEE01000001_gene2167	1.34e-98	306.0	COG0480@1|root,COG0480@2|Bacteria,2GKB3@201174|Actinobacteria,4FEM3@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_508697_1	1304885.AUEY01000005_gene846	5.86e-49	162.0	COG0517@1|root,COG0517@2|Bacteria,1RA25@1224|Proteobacteria,42R80@68525|delta/epsilon subdivisions,2WMW6@28221|Deltaproteobacteria,2MKBU@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
k59_1741491_1	1198232.CYCME_1353	9.55e-82	269.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,4602H@72273|Thiotrichales	72273|Thiotrichales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
k59_685482_1	2340.JV46_03730	8.36e-73	228.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1J543@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_1448655_1	2340.JV46_08270	1.34e-90	280.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1J4T3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Mg2 and Co2 transporter CorB	yfjD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1448655_2	1318628.MARLIPOL_17443	3.01e-12	65.1	2E3XG@1|root,32YUI@2|Bacteria,1N8RF@1224|Proteobacteria,1SCJ3@1236|Gammaproteobacteria,46894@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second- messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
k59_1280163_1	709991.Odosp_2794	1.3e-20	96.3	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,2FMG1@200643|Bacteroidia,22W2A@171551|Porphyromonadaceae	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1622823_2	1463864.JOGO01000015_gene5242	1.58e-12	67.4	COG2050@1|root,COG2050@2|Bacteria,2IKWI@201174|Actinobacteria	201174|Actinobacteria	Q	phenylacetic acid degradation protein	paaI	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
k59_1514385_1	1121035.AUCH01000001_gene1966	6.93e-187	528.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,2KUBN@206389|Rhodocyclales	206389|Rhodocyclales	E	O-acetylhomoserine	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_215525_1	1115632.JAFW01000001_gene4571	5.26e-17	84.0	COG0204@1|root,COG0204@2|Bacteria,2GJ6V@201174|Actinobacteria,1W81S@1268|Micrococcaceae	201174|Actinobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_1105788_1	2340.JV46_06310	2.19e-71	222.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1J5TA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008254,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	iSFxv_1172.SFxv_3035	SurE
k59_1105788_2	1122134.KB893651_gene2188	3.3e-37	131.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1XJ7N@135619|Oceanospirillales	135619|Oceanospirillales	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_1150036_1	1123399.AQVE01000043_gene1561	1.97e-162	497.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,4600V@72273|Thiotrichales	72273|Thiotrichales	E	Vitamin B12 dependent methionine synthase, activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_508726_1	765912.Thimo_2268	1.49e-70	233.0	COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria,1WX8D@135613|Chromatiales	135613|Chromatiales	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_450031_2	713586.KB900536_gene186	1.99e-19	82.8	COG2010@1|root,COG2010@2|Bacteria,1N71Z@1224|Proteobacteria,1SF76@1236|Gammaproteobacteria,1WZJF@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_869906_1	1121405.dsmv_0480	8.79e-71	223.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,42N8B@68525|delta/epsilon subdivisions,2WJ6I@28221|Deltaproteobacteria,2MIR3@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_1804106_2	1249627.D779_3148	2.64e-45	151.0	2DBZI@1|root,2ZC1J@2|Bacteria,1RC57@1224|Proteobacteria,1S2Q2@1236|Gammaproteobacteria,1WY10@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_801763_2	865937.Gilli_1969	3.08e-21	95.1	COG5295@1|root,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	yeeJ	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	DUF5122,Peptidase_S74,YadA_head,YadA_stalk
k59_801767_1	10224.XP_006822006.1	8.83e-26	112.0	2D1AE@1|root,2SHBM@2759|Eukaryota,3AFP7@33154|Opisthokonta,3BY0Y@33208|Metazoa,3DET1@33213|Bilateria	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17
k59_752628_1	1304865.JAGF01000001_gene588	1.05e-61	202.0	28NWB@1|root,2ZBU7@2|Bacteria,2GJ74@201174|Actinobacteria,4F0I6@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3027)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3027
k59_1290771_2	1279015.KB908454_gene1205	1.07e-08	60.1	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1Y3U4@135624|Aeromonadales	135624|Aeromonadales	V	COG2274 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain	-	-	-	ko:K12541	ko02010,map02010	M00330	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.3,3.A.1.109.4	-	-	ABC_membrane,ABC_tran
k59_1290780_1	1396141.BATP01000012_gene2700	1.07e-31	127.0	COG4625@1|root,COG4625@2|Bacteria	2|Bacteria	T	pathogenesis	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG
k59_1631573_1	754476.Q7A_2004	5.47e-35	128.0	COG2755@1|root,COG2755@2|Bacteria,1RHDZ@1224|Proteobacteria,1S60V@1236|Gammaproteobacteria,46145@72273|Thiotrichales	72273|Thiotrichales	E	PFAM GDSL-like Lipase Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
k59_1457538_1	511680.BUTYVIB_01974	3.95e-06	50.1	COG3437@1|root,COG3437@2|Bacteria,1UQJH@1239|Firmicutes,248UM@186801|Clostridia,4BW35@830|Butyrivibrio	186801|Clostridia	KT	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
k59_1457538_2	243277.VC_1140	5.48e-74	231.0	COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,1S1ZX@1236|Gammaproteobacteria,1XUNX@135623|Vibrionales	135623|Vibrionales	J	Belongs to the pseudouridine synthase RsuA family	rluE	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.20	ko:K06181	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
k59_1457538_3	1125863.JAFN01000001_gene1103	1.55e-50	164.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,42RIQ@68525|delta/epsilon subdivisions,2WNC7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM PEBP family protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
k59_1804125_1	1210046.B277_14968	1.6e-92	283.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4FEDQ@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the aspartokinase family	ask	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
k59_1397122_1	717785.HYPMC_0660	7.61e-120	354.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2TSBN@28211|Alphaproteobacteria,3N658@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
k59_1042539_1	935261.JAGL01000051_gene2926	1.07e-135	392.0	COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,2TR1F@28211|Alphaproteobacteria,43H45@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1157215_1	765911.Thivi_1929	4.21e-35	131.0	COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,1S0Z6@1236|Gammaproteobacteria,1WXDJ@135613|Chromatiales	135613|Chromatiales	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1157215_2	396588.Tgr7_1594	1.63e-96	293.0	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,1RMGK@1236|Gammaproteobacteria,1WWHA@135613|Chromatiales	135613|Chromatiales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_633797_1	1286093.C266_01095	1.39e-94	300.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,1K2G2@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_869947_1	479434.Sthe_1318	1.71e-42	146.0	COG0652@1|root,COG0652@2|Bacteria,2G6RE@200795|Chloroflexi	200795|Chloroflexi	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
k59_1524882_2	1163617.SCD_n00558	4.7e-10	58.9	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2VH29@28216|Betaproteobacteria	28216|Betaproteobacteria	S	ABC transporter	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
k59_1692464_1	1049564.TevJSym_ap00510	2.48e-120	365.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1J4U3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CP	CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	nuoL	-	1.6.5.3	ko:K00341,ko:K05559	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_165700_1	1163407.UU7_10705	4.2e-42	159.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1X37J@135614|Xanthomonadales	135614|Xanthomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_1457565_1	1042377.AFPJ01000036_gene1233	6.46e-157	460.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_1631609_1	246200.SPO0825	6.36e-65	211.0	COG0683@1|root,COG0683@2|Bacteria,1PERH@1224|Proteobacteria,2V88A@28211|Alphaproteobacteria,4NDHC@97050|Ruegeria	28211|Alphaproteobacteria	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_574724_1	1049564.TevJSym_cv00020	6.09e-101	305.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,1RQ01@1236|Gammaproteobacteria,1J4TK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	norB	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0016966,GO:0055114	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
k59_869970_1	640081.Dsui_0262	3.67e-80	271.0	COG3290@1|root,COG5001@1|root,COG3290@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KY6J@206389|Rhodocyclales	206389|Rhodocyclales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9
k59_1457566_1	572265.HDEF_0717	5.14e-13	65.5	COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,1S3PA@1236|Gammaproteobacteria,282U1@191675|unclassified Enterobacteriaceae	1236|Gammaproteobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
k59_1457566_2	1397528.Q671_13875	1.62e-87	260.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,1RMW0@1236|Gammaproteobacteria,1XHMM@135619|Oceanospirillales	135619|Oceanospirillales	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
k59_1290817_1	1246995.AFR_10265	6.5e-39	138.0	COG1309@1|root,COG1309@2|Bacteria,2GP92@201174|Actinobacteria,4DB3G@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1573466_1	1396141.BATP01000032_gene4431	1.41e-26	113.0	COG1595@1|root,COG3533@1|root,COG1595@2|Bacteria,COG3533@2|Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	1.3.7.14,1.3.7.15	ko:K03088,ko:K11333	ko00860,ko01110,map00860,map01110	-	R09053,R09060	RC01008	ko00000,ko00001,ko01000,ko03021	-	-	-	Alginate_lyase,Fer4_NifH,Glyco_hydro_cc,Laminin_G_3,Sigma70_r2,Sigma70_r4_2
k59_752685_1	768671.ThimaDRAFT_1443	4.17e-91	276.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,1RNXH@1236|Gammaproteobacteria,1WW4N@135613|Chromatiales	135613|Chromatiales	C	PFAM aldo keto reductase	tas	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_223829_1	637389.Acaty_c1586	1.83e-29	119.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria,2NC37@225057|Acidithiobacillales	225057|Acidithiobacillales	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	-	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_1224234_1	870187.Thini_4228	2.76e-25	103.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,1RMVE@1236|Gammaproteobacteria,461MH@72273|Thiotrichales	72273|Thiotrichales	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding
k59_1224234_2	1123399.AQVE01000003_gene2231	1.91e-101	298.0	COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,1RPIC@1236|Gammaproteobacteria,462RU@72273|Thiotrichales	72273|Thiotrichales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
k59_1575584_1	1042326.AZNV01000051_gene1272	2.59e-40	159.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,4B72Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,EAL,GGDEF,PAS_4,PAS_9
k59_1044814_1	857087.Metme_2789	9.43e-83	261.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1XE25@135618|Methylococcales	135618|Methylococcales	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_1751111_1	1260251.SPISAL_03945	1.25e-32	124.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,1RNUS@1236|Gammaproteobacteria,1WWB4@135613|Chromatiales	135613|Chromatiales	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_1751111_2	269796.Rru_A0367	2.95e-34	125.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,2TV3Q@28211|Alphaproteobacteria,2JS96@204441|Rhodospirillales	204441|Rhodospirillales	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_343282_1	2340.JV46_09140	7.2e-84	274.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J4V8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1044838_1	1117647.M5M_18320	1.65e-49	178.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria,1RQEQ@1236|Gammaproteobacteria,1J4HT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_872209_1	446469.Sked_09120	1.37e-152	442.0	COG1109@1|root,COG1109@2|Bacteria,2GJQA@201174|Actinobacteria	201174|Actinobacteria	G	the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells	manB	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1694522_1	697282.Mettu_0354	6.2e-35	137.0	COG0501@1|root,COG0501@2|Bacteria,1MVU4@1224|Proteobacteria,1RPJ5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Zn-dependent protease with chaperone function	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_517098_1	1540257.JQMW01000002_gene1370	1.34e-27	108.0	COG0569@1|root,COG0569@2|Bacteria,1TQ9H@1239|Firmicutes,249C2@186801|Clostridia,36DGN@31979|Clostridiaceae	186801|Clostridia	P	Potassium uptake protein	ktrC	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_1399120_1	1396141.BATP01000003_gene5181	2.24e-80	265.0	COG1197@1|root,COG1197@2|Bacteria,46S6Y@74201|Verrucomicrobia,2ITM9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	TRCF	-	-	-	-	-	-	-	-	-	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_872224_1	930169.B5T_02627	2.11e-74	238.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1XHAH@135619|Oceanospirillales	135619|Oceanospirillales	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,Pribosyltran
k59_167682_1	566466.NOR53_496	1.39e-36	137.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,1J53S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	GO:0001680,GO:0003674,GO:0003824,GO:0004652,GO:0004810,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016437,GO:0016740,GO:0016772,GO:0016779,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042245,GO:0042780,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0070566,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990817	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
k59_167682_2	745411.B3C1_15317	6.63e-14	67.8	COG3094@1|root,COG3094@2|Bacteria,1MZN6@1224|Proteobacteria,1S70H@1236|Gammaproteobacteria,1J6ZV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Invasion gene expression up-regulator, SirB	-	-	-	-	-	-	-	-	-	-	-	-	SirB
k59_1158892_1	1322246.BN4_10547	2.41e-40	139.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,42SD2@68525|delta/epsilon subdivisions,2WP7H@28221|Deltaproteobacteria,2MC5C@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	ptsN	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
k59_1158892_2	401526.TcarDRAFT_0555	2.36e-09	55.8	COG1544@1|root,COG1544@2|Bacteria,1V1D5@1239|Firmicutes,4H43Y@909932|Negativicutes	909932|Negativicutes	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
k59_695178_1	768671.ThimaDRAFT_2578	1.7e-96	294.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1WX2U@135613|Chromatiales	135613|Chromatiales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_1805715_1	35754.JNYJ01000009_gene2037	5.67e-29	120.0	COG3250@1|root,COG3250@2|Bacteria,2GMAT@201174|Actinobacteria,4DDPJ@85008|Micromonosporales	201174|Actinobacteria	G	Glycosyl hydrolases family 2, TIM barrel domain	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_1399144_1	675817.VDA_000759	2.54e-28	108.0	296Z4@1|root,2ZU7P@2|Bacteria,1PAT0@1224|Proteobacteria,1SW3D@1236|Gammaproteobacteria,1XXPY@135623|Vibrionales	135623|Vibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_1158908_1	2340.JV46_12820	8.83e-39	137.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,1S74N@1236|Gammaproteobacteria,1J6I7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0019720,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061603,GO:0070568,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902757,GO:1902758	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_2604,iEcHS_1320.EcHS_A4080,iEcolC_1368.EcolC_4158,iLF82_1304.LF82_1370,iNRG857_1313.NRG857_19230,iSBO_1134.SBO_3869,iSbBS512_1146.SbBS512_E4329,iUMNK88_1353.UMNK88_4686,ic_1306.c4801	NTP_transf_3
k59_1751163_2	323261.Noc_2593	2.06e-14	77.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1WX0K@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5
k59_167702_1	1335757.SPICUR_05250	2.45e-129	376.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RN4D@1236|Gammaproteobacteria,1WXPM@135613|Chromatiales	135613|Chromatiales	S	PFAM Alcohol dehydrogenase	-	-	-	ko:K12957,ko:K13979	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_872262_1	877421.AUJT01000007_gene722	4.11e-15	77.4	COG0575@1|root,COG0575@2|Bacteria,1V6V6@1239|Firmicutes,24KZJ@186801|Clostridia,27N7I@186928|unclassified Lachnospiraceae	186801|Clostridia	I	CDP-archaeol synthase	-	-	-	-	-	-	-	-	-	-	-	-	CarS-like
k59_872262_2	1192034.CAP_6839	9.09e-14	70.9	COG3380@1|root,COG3380@2|Bacteria,1R5C0@1224|Proteobacteria,435D1@68525|delta/epsilon subdivisions,2X984@28221|Deltaproteobacteria,2Z2IU@29|Myxococcales	28221|Deltaproteobacteria	S	Flavin containing amine oxidoreductase	-	-	-	ko:K06955	-	-	-	-	ko00000	-	-	-	Amino_oxidase,NAD_binding_8
k59_1751188_1	935839.JAGJ01000001_gene1083	7.9e-79	250.0	COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria,4F41A@85017|Promicromonosporaceae	201174|Actinobacteria	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
k59_167733_1	1397528.Q671_01140	5.02e-19	87.4	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,1RNH4@1236|Gammaproteobacteria,1XHDV@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
k59_1633856_1	1232410.KI421414_gene2841	6.48e-49	164.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,42NPG@68525|delta/epsilon subdivisions,2WJVP@28221|Deltaproteobacteria,43RXH@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
k59_1224356_1	1453501.JELR01000002_gene1354	2.02e-74	230.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,1RSNX@1236|Gammaproteobacteria,46631@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG2801 Transposase and inactivated derivatives	ylbG	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve,rve_2,rve_3
k59_1575719_1	1167006.UWK_01948	5.56e-47	167.0	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,42KZP@68525|delta/epsilon subdivisions,2WKSV@28221|Deltaproteobacteria,2MHUQ@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,PAS
k59_1805771_1	1035308.AQYY01000001_gene1660	1.69e-58	194.0	COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,2609N@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
k59_1805771_2	1035308.AQYY01000001_gene1642	4.25e-07	50.4	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,260YE@186807|Peptococcaceae	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_635490_1	713586.KB900536_gene1826	7.07e-61	191.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,1S61A@1236|Gammaproteobacteria,1WYDV@135613|Chromatiales	135613|Chromatiales	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
k59_343389_1	1168034.FH5T_09955	7.62e-219	649.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,4NFKH@976|Bacteroidetes,2FNH9@200643|Bacteroidia	976|Bacteroidetes	E	Glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_635494_1	1304865.JAGF01000001_gene2665	1.67e-109	342.0	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4F0HT@85016|Cellulomonadaceae	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_459168_1	1499967.BAYZ01000019_gene6268	4.36e-51	183.0	COG1026@1|root,COG1026@2|Bacteria,2NQI2@2323|unclassified Bacteria	2|Bacteria	S	Peptidase M16C associated	CP_0875	-	-	ko:K06972	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M16C_assoc,Peptidase_M16,Peptidase_M16_C
k59_1045009_1	258052.JNYV01000016_gene3323	8.74e-61	205.0	COG2072@1|root,COG2072@2|Bacteria,2GJEA@201174|Actinobacteria,2M2CG@2063|Kitasatospora	201174|Actinobacteria	P	Flavin-binding monooxygenase-like	-	-	-	ko:K10215	ko00627,ko01120,map00627,map01120	-	R07836,R07837	RC02100,RC03121	ko00000,ko00001,ko01000	-	-	-	FMO-like,NAD_binding_8,Pyr_redox_2,Pyr_redox_3
k59_635499_1	446469.Sked_36030	7.43e-90	274.0	COG0407@1|root,COG0407@2|Bacteria,2GMY6@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_343399_1	1193181.BN10_990032	5.95e-17	77.8	COG0569@1|root,COG0569@2|Bacteria,2GK4N@201174|Actinobacteria,4FED5@85021|Intrasporangiaceae	201174|Actinobacteria	P	Potassium transporter TrkA	ceoB	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_343399_2	1385521.N803_07225	2.3e-107	313.0	COG0569@1|root,COG0569@2|Bacteria,2GKB9@201174|Actinobacteria,4FEXE@85021|Intrasporangiaceae	201174|Actinobacteria	P	Portal protein	ceoC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_576443_1	313628.LNTAR_23894	1.22e-15	81.6	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_459189_1	313628.LNTAR_15792	7.8e-16	82.8	COG3605@1|root,COG3605@2|Bacteria	2|Bacteria	T	phosphoenolpyruvate-protein phosphotransferase activity	ptsP	GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008965,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0016775,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:1901564,GO:1901698	2.7.13.3,2.7.3.9	ko:K07683,ko:K08483,ko:K08484,ko:K10851	ko02020,ko02060,map02020,map02060	M00483	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022	8.A.7	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_1575790_1	187272.Mlg_2128	3.74e-126	389.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1WX1D@135613|Chromatiales	135613|Chromatiales	I	acyl-CoA dehydrogenase	-	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_695309_1	1454010.JEOE01000012_gene1615	3.98e-62	204.0	COG0580@1|root,COG0580@2|Bacteria,2GKK3@201174|Actinobacteria,4F0YW@85016|Cellulomonadaceae	201174|Actinobacteria	G	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
k59_1045064_1	1502850.FG91_00526	1.28e-36	134.0	COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,2TUWC@28211|Alphaproteobacteria,2K2PP@204457|Sphingomonadales	204457|Sphingomonadales	Q	2-keto-4-pentenoate hydratase	-	-	4.2.1.132,4.2.1.80	ko:K18364	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R02601,R05864	RC00750,RC02676	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
k59_343431_1	666686.B1NLA3E_04190	1.34e-45	159.0	COG0411@1|root,COG0411@2|Bacteria,1TR0P@1239|Firmicutes,4HASG@91061|Bacilli,1ZB0Q@1386|Bacillus	91061|Bacilli	E	COG0411 ABC-type branched-chain amino acid transport systems, ATPase component	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_576474_1	765910.MARPU_10625	9.06e-64	219.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales	135613|Chromatiales	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HTH_12,OB_RNB,RNB,S1
k59_294726_1	768671.ThimaDRAFT_1325	8.44e-44	156.0	COG1249@1|root,COG1249@2|Bacteria,1MXQ3@1224|Proteobacteria,1RQ44@1236|Gammaproteobacteria,1X080@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_529560_2	1144275.COCOR_04407	7.28e-38	137.0	COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,42MEY@68525|delta/epsilon subdivisions,2WM0F@28221|Deltaproteobacteria,2YXA9@29|Myxococcales	28221|Deltaproteobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
k59_1234069_1	1208323.B30_20061	2.04e-19	87.0	COG4191@1|root,COG4191@2|Bacteria,1MVK7@1224|Proteobacteria,2TR44@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	signal transduction histidine kinase	regM	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_1234069_2	1288298.rosmuc_01475	2.64e-43	154.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TU0K@28211|Alphaproteobacteria,46PEV@74030|Roseovarius	28211|Alphaproteobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_354305_1	207559.Dde_1502	1.54e-86	263.0	COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,42MX8@68525|delta/epsilon subdivisions,2WIK0@28221|Deltaproteobacteria,2M86I@213115|Desulfovibrionales	28221|Deltaproteobacteria	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	-	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
k59_354305_2	880072.Desac_0379	1.18e-08	55.8	COG0618@1|root,COG0618@2|Bacteria,1N0JS@1224|Proteobacteria,42P1S@68525|delta/epsilon subdivisions,2WJV0@28221|Deltaproteobacteria,2MQTH@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Phosphoesterase RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
k59_60804_1	519989.ECTPHS_12968	7.46e-29	110.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,1S74N@1236|Gammaproteobacteria,1WY76@135613|Chromatiales	135613|Chromatiales	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
k59_1468887_1	1123279.ATUS01000001_gene2226	1.52e-39	144.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1J4EF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	COG1519 3-deoxy-D-manno-octulosonic-acid transferase	waaA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	iECNA114_1301.ECNA114_3778,iUMNK88_1353.UMNK88_4417	Glycos_transf_1,Glycos_transf_N
k59_1468887_2	497321.C664_15243	2.59e-18	84.0	COG0279@1|root,COG0615@1|root,COG0279@2|Bacteria,COG0615@2|Bacteria,1NJ8X@1224|Proteobacteria,2VN12@28216|Betaproteobacteria,2KVWJ@206389|Rhodocyclales	206389|Rhodocyclales	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,SIS_2
k59_1234076_1	1305732.JAGG01000001_gene327	1.21e-42	157.0	COG0471@1|root,COG0471@2|Bacteria,2GVHZ@201174|Actinobacteria,4FQPQ@85023|Microbacteriaceae	201174|Actinobacteria	P	Sodium:sulfate symporter transmembrane region	sdcS	-	-	ko:K03319,ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47,2.A.47.1	-	-	Na_sulph_symp
k59_1175367_1	62928.azo3040	8.49e-60	201.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VK75@28216|Betaproteobacteria,2KVQR@206389|Rhodocyclales	28216|Betaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_529573_1	768671.ThimaDRAFT_3656	1.56e-112	351.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RR1B@1236|Gammaproteobacteria,1WW1P@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM ATP-dependent helicase HrpB	-	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_294739_1	713586.KB900536_gene805	1.67e-76	237.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1RQ2D@1236|Gammaproteobacteria,1WXUX@135613|Chromatiales	135613|Chromatiales	I	6-phosphogluconate dehydrogenase, NAD-binding	-	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_1293612_1	1123392.AQWL01000001_gene1318	3e-140	423.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2VJSI@28216|Betaproteobacteria,1KT3X@119069|Hydrogenophilales	119069|Hydrogenophilales	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
k59_647041_1	743718.Isova_2230	5.16e-59	203.0	COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4F5ZR@85017|Promicromonosporaceae	201174|Actinobacteria	C	Molydopterin dinucleotide binding domain	nasC	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1116641_1	933262.AXAM01000106_gene2631	8.33e-19	86.7	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,42R11@68525|delta/epsilon subdivisions,2WMWN@28221|Deltaproteobacteria,2MMZB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_1116641_2	1121434.AULY01000007_gene1283	2.15e-53	181.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,42R11@68525|delta/epsilon subdivisions,2WMWN@28221|Deltaproteobacteria,2MBFA@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_1410096_1	1123508.JH636440_gene2280	1.7e-42	162.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXDF@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_1821918_1	1267005.KB911259_gene3707	1.9e-121	382.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS2I@28211|Alphaproteobacteria,3N67W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
k59_470851_1	1032480.MLP_29660	1.19e-90	276.0	COG0482@1|root,COG0482@2|Bacteria,2GIUQ@201174|Actinobacteria,4DPXG@85009|Propionibacteriales	201174|Actinobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_294748_1	1384056.N787_09095	1.33e-51	171.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1X38C@135614|Xanthomonadales	135614|Xanthomonadales	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
k59_1762312_1	1205680.CAKO01000040_gene1062	1.62e-97	299.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_1586152_1	396588.Tgr7_0944	7.2e-42	147.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,1WXTC@135613|Chromatiales	135613|Chromatiales	L	transposase IS116 IS110 IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1410110_1	313612.L8106_18651	2.16e-07	57.8	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H7TU@1150|Oscillatoriales	1117|Cyanobacteria	T	COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,Response_reg
k59_412138_2	795797.C497_10988	4.47e-16	75.1	COG0713@1|root,arCOG03073@2157|Archaea,2XXW4@28890|Euryarchaeota,23W1K@183963|Halobacteria	183963|Halobacteria	C	NADH ubiquinone oxidoreductase subunit 11 or 4L (Chain K)	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
k59_588311_1	1123400.KB904758_gene2205	3.84e-155	445.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,1RP2I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0798 Arsenite efflux pump ACR3 and related permeases	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
k59_588311_2	1123368.AUIS01000014_gene2288	8.12e-39	133.0	COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,1S2YD@1236|Gammaproteobacteria,2NCUY@225057|Acidithiobacillales	225057|Acidithiobacillales	T	low molecular weight	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
k59_1410114_1	266264.Rmet_3433	2.19e-89	268.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2VHMC@28216|Betaproteobacteria,1K2Q4@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM beta-lactamase domain protein	ycbL	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_705780_1	1121405.dsmv_0967	9.23e-100	306.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,2MHZK@213118|Desulfobacterales	28221|Deltaproteobacteria	EH	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_529605_1	269796.Rru_A0618	5.05e-56	190.0	COG0477@1|root,COG2814@2|Bacteria,1MW95@1224|Proteobacteria,2TS8H@28211|Alphaproteobacteria,2JQIK@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Photosynthetic complex (LH1) assembly protein LhaA	lhaA	-	-	ko:K08226	-	-	-	-	ko00000,ko02000	2.A.1.41	-	-	PUCC
k59_1821948_1	590998.Celf_3571	2.34e-70	228.0	COG2966@1|root,COG3610@1|root,COG2966@2|Bacteria,COG3610@2|Bacteria,2HXZX@201174|Actinobacteria,4F25F@85016|Cellulomonadaceae	201174|Actinobacteria	S	Threonine/Serine exporter, ThrE	-	-	-	-	-	-	-	-	-	-	-	-	ThrE
k59_764402_1	713586.KB900536_gene3071	1.58e-91	278.0	COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,1RNV8@1236|Gammaproteobacteria,1WWYH@135613|Chromatiales	135613|Chromatiales	E	Bacterial transglutaminase-like N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_1762323_1	1033802.SSPSH_000424	3.66e-60	214.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0729 Outer membrane protein	tamA	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,POTRA_TamA_1
k59_1527465_1	446466.Cfla_1934	1.61e-168	493.0	COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria,4F0S9@85016|Cellulomonadaceae	201174|Actinobacteria	G	Belongs to the transketolase family	tkt	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_60860_1	247634.GPB2148_3092	1.18e-35	129.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1J5PY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	Q	E COG1126 ABC-type polar amino acid transport system, ATPase component	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_60860_2	1121438.JNJA01000002_gene3658	3.9e-30	122.0	COG1463@1|root,COG1463@2|Bacteria,1Q6ZU@1224|Proteobacteria,42RZ3@68525|delta/epsilon subdivisions,2WNF0@28221|Deltaproteobacteria,2M8JA@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_1175404_1	471853.Bcav_1572	2.76e-35	126.0	COG1414@1|root,COG1414@2|Bacteria,2GKB0@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	ltbR	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_764409_1	391615.ABSJ01000030_gene806	4.58e-66	212.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1J4MQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
k59_1762325_1	287.DR97_2875	3.43e-158	464.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1YEIQ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdZ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_1762325_2	713587.THITH_01775	7.26e-125	360.0	COG0209@1|root,COG0209@2|Bacteria,1P4EH@1224|Proteobacteria,1RP1A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	COG0209 Ribonucleotide reductase, alpha subunit	nrdJb	-	-	-	-	-	-	-	-	-	-	-	-
k59_1744_2	521393.JH806634_gene2121	1.95e-08	58.5	COG0463@1|root,COG0463@2|Bacteria,2GM44@201174|Actinobacteria,4D88B@85005|Actinomycetales	201174|Actinobacteria	M	Glycosyltransferase, group 2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_118762_1	1123400.KB904766_gene2958	1.73e-11	69.3	COG0457@1|root,COG0457@2|Bacteria,1N3T7@1224|Proteobacteria,1T1KY@1236|Gammaproteobacteria,46360@72273|Thiotrichales	72273|Thiotrichales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
k59_118762_2	1177154.Y5S_01490	3.13e-28	117.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1XIQW@135619|Oceanospirillales	135619|Oceanospirillales	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
k59_1293687_2	1049564.TevJSym_be00060	1.83e-85	256.0	COG0535@1|root,COG0535@2|Bacteria,1QUQ6@1224|Proteobacteria,1T20T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
k59_941523_1	107636.JQNK01000009_gene3513	1.24e-227	639.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,370BU@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1351504_1	1120941.AUBL01000029_gene1180	1.77e-48	176.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,4D3UH@85005|Actinomycetales	201174|Actinobacteria	L	DNA helicase	pcrA	GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1703713_1	1049564.TevJSym_ac01600	2.4e-71	226.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1J7FM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	GM	NAD(P)H-binding	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
k59_882818_1	552811.Dehly_1700	6.4e-78	235.0	COG1974@1|root,COG1974@2|Bacteria	2|Bacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0032991,GO:0032993,GO:0043565,GO:0097159,GO:1901363	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	HTH_3,LexA_DNA_bind,Peptidase_S24
k59_1293690_1	1049564.TevJSym_au00560	5.63e-19	87.4	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,1J50G@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
k59_1293690_2	998088.B565_0719	1.65e-41	141.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,1Y4C4@135624|Aeromonadales	135624|Aeromonadales	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
k59_1234133_1	1046724.KB889908_gene961	1.36e-67	224.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,464KX@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604	PBP_dimer,Transpeptidase
k59_1762341_1	1249627.D779_1617	3.06e-79	244.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales	135613|Chromatiales	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
k59_354418_2	566466.NOR53_3178	2.24e-41	140.0	2E4PM@1|root,32P93@2|Bacteria,1N4SK@1224|Proteobacteria,1SEXN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_529654_2	497964.CfE428DRAFT_5240	2.66e-115	338.0	COG2326@1|root,COG2326@2|Bacteria,46SAH@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_118778_1	314278.NB231_15398	3.48e-35	133.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1WWGT@135613|Chromatiales	135613|Chromatiales	S	Permease YjgP YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_1058184_1	768710.DesyoDRAFT_4030	5.39e-49	176.0	COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,248EH@186801|Clostridia,260Y1@186807|Peptococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	cadA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_354421_1	935839.JAGJ01000005_gene2710	2.19e-107	317.0	COG0638@1|root,COG0638@2|Bacteria,2GKZ1@201174|Actinobacteria,4F44K@85017|Promicromonosporaceae	201174|Actinobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
k59_354421_2	1380354.JIAN01000010_gene3024	9.09e-266	735.0	COG0638@1|root,COG0638@2|Bacteria,2GMC6@201174|Actinobacteria,4F0NN@85016|Cellulomonadaceae	201174|Actinobacteria	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
k59_941558_1	1121405.dsmv_3066	8.59e-79	261.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,2MHU0@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_294821_1	1209072.ALBT01000031_gene1859	6.8e-82	253.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1FG6Q@10|Cellvibrio	1236|Gammaproteobacteria	K	ParB-like nuclease domain	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_1703737_1	367299.JOEE01000010_gene3282	3.39e-104	312.0	COG0162@1|root,COG0162@2|Bacteria,2GJPR@201174|Actinobacteria,4FEQZ@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_1703737_2	1303692.SFUL_5594	2.6e-23	97.1	COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism	add2	GO:0000034,GO:0003674,GO:0003824,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046083,GO:0046100,GO:0046101,GO:0046112,GO:0046113,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.5.4.4,3.5.4.40	ko:K01488,ko:K18286	ko00130,ko00230,ko01100,ko01110,ko05340,map00130,map00230,map01100,map01110,map05340	-	R01560,R02556,R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
k59_1468976_1	76114.c1A212	1.55e-72	231.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VMHS@28216|Betaproteobacteria,2KUQ2@206389|Rhodocyclales	206389|Rhodocyclales	I	Belongs to the thiolase family	fadA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_412218_1	367299.JOEE01000004_gene1277	3.08e-32	118.0	COG0406@1|root,COG0406@2|Bacteria,2GJYU@201174|Actinobacteria,4FH6Q@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the phosphoglycerate mutase family	gpmB	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237	3.1.3.85,5.4.2.11	ko:K01834,ko:K22306	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
k59_412218_2	1193181.BN10_310003	5.26e-72	218.0	COG0799@1|root,COG0799@2|Bacteria,2IKZ3@201174|Actinobacteria,4FGS2@85021|Intrasporangiaceae	201174|Actinobacteria	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
k59_412218_3	1121017.AUFG01000071_gene596	1.51e-35	127.0	COG1057@1|root,COG1057@2|Bacteria,2GMFZ@201174|Actinobacteria,4FF49@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_1411204_2	153948.NAL212_2732	1.89e-59	192.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2VJ4G@28216|Betaproteobacteria,371X0@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_1176420_1	160488.PP_4514	2.41e-61	210.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,1YV2D@136845|Pseudomonas putida group	1236|Gammaproteobacteria	M	Surface antigen variable number	plpD	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k59_62301_2	742766.HMPREF9455_00530	1.52e-45	151.0	COG3324@1|root,COG3324@2|Bacteria,4NQSB@976|Bacteroidetes	976|Bacteroidetes	S	COGs COG3324 protein related to lactoylglutathione lyase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
k59_1117524_1	1304865.JAGF01000001_gene2107	3.12e-110	346.0	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,4F0TJ@85016|Cellulomonadaceae	201174|Actinobacteria	S	Uncharacterised protein family (UPF0182)	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_413117_1	1454004.AW11_00535	2.31e-67	220.0	COG2267@1|root,COG2267@2|Bacteria,1QTZP@1224|Proteobacteria,2VKTF@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
k59_119763_1	1121091.AUMP01000027_gene754	2.31e-25	103.0	COG3764@1|root,COG3764@2|Bacteria,1V1RS@1239|Firmicutes,4HFWK@91061|Bacilli	91061|Bacilli	M	COG3764 Sortase (surface protein transpeptidase)	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
k59_1704748_1	1384054.N790_06315	5.02e-99	302.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1X41V@135614|Xanthomonadales	135614|Xanthomonadales	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Cys_Met_Meta_PP
k59_1411208_1	742742.HMPREF9452_02080	1.06e-13	75.1	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4CUM8@84998|Coriobacteriia	201174|Actinobacteria	D	Belongs to the 'phage' integrase family. XerC subfamily	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1235153_1	713587.THITH_15710	3.9e-07	53.1	COG4967@1|root,COG4967@2|Bacteria	2|Bacteria	NU	type IV pilus modification protein PilV	pilV	-	-	ko:K02671	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl
k59_355780_1	1120958.AULD01000007_gene1101	1.14e-59	203.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria,4FN2F@85023|Microbacteriaceae	201174|Actinobacteria	O	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_530683_1	1121405.dsmv_1649	8.32e-97	313.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,42KZ7@68525|delta/epsilon subdivisions,2WJP6@28221|Deltaproteobacteria,2MIWZ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487	GATase_6,SIS
k59_62309_1	323850.Shew_2063	1.15e-19	90.1	COG0705@1|root,COG0705@2|Bacteria,1N8NS@1224|Proteobacteria,1SD4M@1236|Gammaproteobacteria,2QBY9@267890|Shewanellaceae	1236|Gammaproteobacteria	S	PFAM Rhomboid family protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
k59_1592220_2	926564.KI911686_gene5524	3.5e-174	492.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4F3KR@85017|Promicromonosporaceae	201174|Actinobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1592220_3	1194165.CAJF01000050_gene1533	2.31e-29	121.0	COG4733@1|root,COG4733@2|Bacteria,2GMKC@201174|Actinobacteria,4FKWD@85023|Microbacteriaceae	201174|Actinobacteria	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
k59_246166_1	1298593.TOL_1770	1.02e-12	66.2	COG1032@1|root,COG1032@2|Bacteria,1P9J0@1224|Proteobacteria,1RXYN@1236|Gammaproteobacteria,1XJ3H@135619|Oceanospirillales	135619|Oceanospirillales	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_1066379_1	1049564.TevJSym_af00200	8.47e-106	320.0	COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1J4G5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iJN746.PP_1032,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833	GATase,GMP_synt_C,NAD_synthase
k59_1122043_2	367299.JOEE01000001_gene1709	4.45e-101	300.0	COG1129@1|root,COG1129@2|Bacteria,2GJDV@201174|Actinobacteria,4FES6@85021|Intrasporangiaceae	201174|Actinobacteria	G	ABC transporter, ATP-binding protein	-	-	3.6.3.17	ko:K02056,ko:K10545	ko02010,map02010	M00215,M00221	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.4	-	-	ABC_tran
k59_1533815_1	1122604.JONR01000043_gene3181	1.67e-25	100.0	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,1S5XA@1236|Gammaproteobacteria,1X5Z6@135614|Xanthomonadales	135614|Xanthomonadales	O	cytochrome c oxidase assembly protein	cox11	-	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
k59_1533815_2	1268635.Loa_02846	1.35e-12	68.6	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1JCXV@118969|Legionellales	118969|Legionellales	C	Cytochrome c oxidase subunit III	coxC	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_653658_1	1318628.MARLIPOL_14260	3.76e-47	166.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,465HJ@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iAPECO1_1312.APECO1_1898,iECNA114_1301.ECNA114_0081,iECOK1_1307.ECOK1_0089,iECP_1309.ECP_0090,iECS88_1305.ECS88_0091,iECSF_1327.ECSF_0098,iLF82_1304.LF82_1418,iNRG857_1313.NRG857_00450,iUMN146_1321.UM146_23225,iUTI89_1310.UTI89_C0097	Mur_ligase_C,Mur_ligase_M
k59_1709917_1	243233.MCA0345	2.49e-96	290.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1XE3A@135618|Methylococcales	135618|Methylococcales	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
k59_769737_1	765911.Thivi_2387	6.92e-42	147.0	COG0500@1|root,COG2226@2|Bacteria,1RDI3@1224|Proteobacteria,1SZC2@1236|Gammaproteobacteria,1X2EH@135613|Chromatiales	135613|Chromatiales	Q	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
k59_125341_1	1449063.JMLS01000001_gene4130	4.71e-57	199.0	COG0367@1|root,COG0367@2|Bacteria,1TRPB@1239|Firmicutes,4HAIP@91061|Bacilli,26QDS@186822|Paenibacillaceae	91061|Bacilli	E	Asparagine synthase	asnH	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_1066409_2	373903.Hore_01380	5.24e-59	191.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,3WA6N@53433|Halanaerobiales	186801|Clostridia	J	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_418537_1	367299.JOEE01000004_gene952	1.79e-120	346.0	COG1595@1|root,COG1595@2|Bacteria,2GJ02@201174|Actinobacteria,4FF1Y@85021|Intrasporangiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigH	GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1066418_1	935567.JAES01000016_gene1500	2.89e-13	70.9	COG4970@1|root,COG4970@2|Bacteria,1Q92Z@1224|Proteobacteria,1SEPV@1236|Gammaproteobacteria,1X7Z2@135614|Xanthomonadales	135614|Xanthomonadales	NU	COG4970 Tfp pilus assembly protein FimT	-	-	-	ko:K08084	-	-	-	-	ko00000,ko02044	3.A.15.2	-	-	GspH,N_methyl
k59_184083_1	997346.HMPREF9374_3800	1.35e-14	79.7	COG3044@1|root,COG3044@2|Bacteria,1TPJ9@1239|Firmicutes,4HA35@91061|Bacilli,27AYF@186824|Thermoactinomycetaceae	91061|Bacilli	S	Predicted ATPase of the ABC class	-	-	-	-	-	-	-	-	-	-	-	-	ABC_ATPase
k59_1122051_1	1028800.RG540_PA10240	5.11e-186	530.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,4BAAY@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1122051_2	1041147.AUFB01000032_gene5881	5.5e-156	441.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TS16@28211|Alphaproteobacteria,4BB8M@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_12525_1	649743.HMPREF0972_00496	4.4e-30	123.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4D3RZ@85005|Actinomycetales	201174|Actinobacteria	M	Transglycosylase	pbp5	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
k59_246222_1	5911.EAS06873	7.19e-12	72.4	KOG3689@1|root,KOG3689@2759|Eukaryota,3ZBNB@5878|Ciliophora	5878|Ciliophora	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF
k59_653683_1	697282.Mettu_4037	1.05e-158	455.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1XDX9@135618|Methylococcales	1236|Gammaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	-	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	iYL1228.KPN_02462	AdoHcyase,AdoHcyase_NAD
k59_301347_1	1049564.TevJSym_bn00090	2.89e-59	191.0	COG0810@1|root,COG0810@2|Bacteria,1R330@1224|Proteobacteria,1RQAX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Periplasmic protein TonB links inner and outer membranes	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
k59_301347_2	765913.ThidrDRAFT_2090	2.8e-07	50.4	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1WX8T@135613|Chromatiales	135613|Chromatiales	K	Belongs to the UPF0301 (AlgH) family	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_1476974_1	768671.ThimaDRAFT_4347	4.56e-45	154.0	COG0583@1|root,COG0583@2|Bacteria,1MVHT@1224|Proteobacteria,1RN7G@1236|Gammaproteobacteria,1WXTT@135613|Chromatiales	135613|Chromatiales	K	PFAM HTH transcriptional regulator, LysR	-	-	-	ko:K03717	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_1476974_2	1205908.AKXW01000086_gene2124	4.49e-24	102.0	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,1RPAE@1236|Gammaproteobacteria,1XUDM@135623|Vibrionales	135623|Vibrionales	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_125364_1	1321778.HMPREF1982_00469	1.95e-07	56.2	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_125364_2	357808.RoseRS_3212	1.26e-05	47.0	COG0664@1|root,COG1136@1|root,COG0664@2|Bacteria,COG1136@2|Bacteria,2G6C9@200795|Chloroflexi,37685@32061|Chloroflexia	32061|Chloroflexia	V	ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,cNMP_binding
k59_892887_1	1163409.UUA_10491	7.55e-17	76.6	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,1X3YF@135614|Xanthomonadales	135614|Xanthomonadales	F	GTP cyclohydrolase	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
k59_892887_2	338969.Rfer_1232	4.26e-42	147.0	COG1234@1|root,COG1234@2|Bacteria,1PPRD@1224|Proteobacteria,2VNMY@28216|Betaproteobacteria,4AGEE@80864|Comamonadaceae	28216|Betaproteobacteria	S	Beta-lactamase superfamily domain	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
k59_1478001_2	367299.JOEE01000002_gene2591	1.56e-95	280.0	COG2193@1|root,COG2193@2|Bacteria,2GJEI@201174|Actinobacteria,4FGGP@85021|Intrasporangiaceae	201174|Actinobacteria	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	bfr	GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
k59_713137_1	631362.Thi970DRAFT_02744	1.17e-47	170.0	COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1RMXU@1236|Gammaproteobacteria,1WXIE@135613|Chromatiales	135613|Chromatiales	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21.2	-	-	SSF
k59_536915_1	338963.Pcar_1239	7.16e-129	378.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,43TT3@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_1067490_1	321327.CYA_1897	4.7e-64	213.0	COG2939@1|root,COG2939@2|Bacteria,1G45M@1117|Cyanobacteria,1H2JR@1129|Synechococcus	1117|Cyanobacteria	E	Peptidase, S10 (Carboxypeptidase Y) family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
k59_1122669_1	1255043.TVNIR_0577	2.61e-58	186.0	COG5156@1|root,COG5156@2|Bacteria,1N53Q@1224|Proteobacteria,1SQTD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	DO	anaphase-promoting complex-dependent catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1832211_1	502347.ESCAB7627_4725	4.02e-77	239.0	COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,1RP2S@1236|Gammaproteobacteria,3XNDJ@561|Escherichia	1236|Gammaproteobacteria	F	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose	hldD	GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008712,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0033692,GO:0034637,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0071704,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901576,GO:1903509	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iPC815.YPO0058,iYL1228.KPN_03963	Epimerase
k59_830336_1	1280948.HY36_08925	1.54e-33	132.0	COG0596@1|root,COG0596@2|Bacteria,1N6BS@1224|Proteobacteria	1224|Proteobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_184843_1	367299.JOEE01000007_gene6	3.06e-30	117.0	COG0213@1|root,COG0213@2|Bacteria,2GJH5@201174|Actinobacteria,4FETB@85021|Intrasporangiaceae	201174|Actinobacteria	F	pyrimidine-nucleoside phosphorylase	deoA	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
k59_184843_2	367299.JOEE01000007_gene5	2.16e-51	172.0	COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria,4FEWW@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3313c	A_deaminase
k59_595385_1	626887.J057_16830	4.03e-110	324.0	COG4663@1|root,COG4663@2|Bacteria,1MUA1@1224|Proteobacteria,1RYNZ@1236|Gammaproteobacteria,469AV@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	COG4663 TRAP-type mannitol chloroaromatic compound transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1005305_1	2340.JV46_11930	1.29e-29	114.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1J4U9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	antiporter	yrbG	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_1005305_2	1453501.JELR01000002_gene109	4.22e-21	84.3	2E4UA@1|root,32ZNM@2|Bacteria,1NAZR@1224|Proteobacteria,1SC82@1236|Gammaproteobacteria,4693Y@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1005305_3	1198232.CYCME_0821	5.4e-28	108.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,45ZN2@72273|Thiotrichales	72273|Thiotrichales	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_830339_1	1123261.AXDW01000003_gene1861	2.51e-31	127.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1X3SF@135614|Xanthomonadales	135614|Xanthomonadales	U	Type II secretory pathway, component HofQ	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_1243007_1	1122194.AUHU01000002_gene2720	1.35e-79	251.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,4650E@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043170,GO:0044425,GO:0044459,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901564	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_1710579_1	388051.AUFE01000020_gene4184	3.4e-64	207.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VI9I@28216|Betaproteobacteria,1K00W@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Ammonium transporter	-	-	-	ko:K03320,ko:K06580	-	-	-	-	ko00000,ko02000,ko04090	1.A.11,1.A.11.4	-	-	Ammonium_transp
k59_1592895_1	455436.DS989810_gene750	4.33e-79	260.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,465F9@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_364665_2	105559.Nwat_0640	8.28e-10	58.5	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WX6V@135613|Chromatiales	135613|Chromatiales	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_1710582_1	319225.Plut_0997	1.49e-37	144.0	COG1074@1|root,COG1074@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase activity	recB	-	3.1.11.5,3.6.4.12	ko:K03406,ko:K03582,ko:K16898	ko02020,ko02030,ko03440,map02020,map02030,map03440	-	-	-	ko00000,ko00001,ko01000,ko02035,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_892925_1	523791.Kkor_0690	1.46e-136	402.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1XH8C@135619|Oceanospirillales	135619|Oceanospirillales	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_713167_1	1122604.JONR01000004_gene889	2.47e-70	236.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X5MD@135614|Xanthomonadales	135614|Xanthomonadales	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_536938_1	365044.Pnap_1005	1.32e-73	243.0	COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,2VJMQ@28216|Betaproteobacteria,4AB6F@80864|Comamonadaceae	28216|Betaproteobacteria	HJM	Mur ligase, middle domain protein	cphA1	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M,RimK
k59_1592907_1	717785.HYPMC_1107	1.09e-13	72.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,3N69V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
k59_1592907_2	582899.Hden_2346	9.56e-94	283.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2TS2D@28211|Alphaproteobacteria,3N6SU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
k59_247677_1	1172188.KB911820_gene2792	1.32e-47	165.0	COG0604@1|root,COG0604@2|Bacteria,2GN47@201174|Actinobacteria,4FEIZ@85021|Intrasporangiaceae	201174|Actinobacteria	C	NAD(P)H quinone oxidoreductase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
k59_71213_1	717785.HYPMC_3831	6.34e-72	228.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2TVQR@28211|Alphaproteobacteria,3N6X0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_1005324_1	1038859.AXAU01000027_gene2243	2.41e-106	327.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,3JRVJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR_N,TPP_enzyme_C
k59_1304134_1	497964.CfE428DRAFT_2230	8.47e-81	259.0	COG0843@1|root,COG0843@2|Bacteria,46S4Q@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_830363_1	713587.THITH_07015	1.39e-64	211.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,1WXJN@135613|Chromatiales	135613|Chromatiales	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_184873_1	105559.Nwat_0028	0.000129	44.7	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1WVW7@135613|Chromatiales	135613|Chromatiales	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_184873_2	1121374.KB891575_gene936	1.12e-16	80.9	COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,1RNKH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	yibQ	-	-	ko:K09798	-	-	-	-	ko00000	-	-	-	Polysacc_deac_2
k59_71218_1	477184.KYC_04727	2.18e-08	55.1	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2VJM3@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Methyltransferase	ubiE_1	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_1067536_1	107636.JQNK01000009_gene3513	1.65e-135	398.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,370BU@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1769036_2	1049564.TevJSym_ac01030	1.25e-108	323.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1J9BP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
k59_419289_1	1146883.BLASA_1080	1.24e-24	101.0	COG3328@1|root,COG3328@2|Bacteria,2H9CR@201174|Actinobacteria	201174|Actinobacteria	L	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_419289_2	1299327.I546_1101	7.03e-59	196.0	COG3328@1|root,COG3328@2|Bacteria,2H9CR@201174|Actinobacteria,2371V@1762|Mycobacteriaceae	201174|Actinobacteria	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_419289_3	1479623.JHEL01000014_gene2122	9.09e-15	72.8	COG0604@1|root,COG0604@2|Bacteria,2GKYZ@201174|Actinobacteria,4FN4T@85023|Microbacteriaceae	201174|Actinobacteria	C	Zinc-binding dehydrogenase	adhT	-	-	ko:K19745	ko00640,ko01100,map00640,map01100	-	R00919	RC00095	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_302022_1	1210884.HG799466_gene12431	1.25e-70	229.0	COG0119@1|root,COG0119@2|Bacteria,2IX7Z@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1534552_1	1265313.HRUBRA_02490	3.18e-76	252.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1J57N@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_595428_1	1123401.JHYQ01000037_gene1648	5.55e-21	87.4	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RYHN@1236|Gammaproteobacteria,460J6@72273|Thiotrichales	72273|Thiotrichales	P	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS_2
k59_247723_1	367299.JOEE01000004_gene1361	2.85e-71	228.0	COG0772@1|root,COG0772@2|Bacteria,2GKXP@201174|Actinobacteria,4FEC0@85021|Intrasporangiaceae	201174|Actinobacteria	D	Belongs to the SEDS family	ftsW	GO:0008150,GO:0040007	2.4.1.227	ko:K02563,ko:K03588	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011,ko02000,ko03036	2.A.103.1	GT28	-	FTSW_RODA_SPOVE
k59_1478082_1	997350.HMPREF9129_1309	5.56e-18	86.7	COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,247VY@186801|Clostridia,22HDE@1570339|Peptoniphilaceae	186801|Clostridia	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
k59_1304164_1	1298593.TOL_1924	1.53e-15	80.9	COG2831@1|root,COG2831@2|Bacteria,1QUVE@1224|Proteobacteria,1T229@1236|Gammaproteobacteria,1XRZ6@135619|Oceanospirillales	135619|Oceanospirillales	U	hemolysin activation secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_654503_2	1123392.AQWL01000009_gene1121	2.61e-41	152.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJI0@28216|Betaproteobacteria,1KSRU@119069|Hydrogenophilales	119069|Hydrogenophilales	P	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_833961_1	593907.Celgi_1384	1.18e-103	329.0	COG1391@1|root,COG1391@2|Bacteria,2GJ91@201174|Actinobacteria,4F0U3@85016|Cellulomonadaceae	201174|Actinobacteria	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_1308946_1	765911.Thivi_3112	1.91e-86	258.0	COG1150@1|root,COG1150@2|Bacteria,1R874@1224|Proteobacteria,1SHQ0@1236|Gammaproteobacteria,1WZZ0@135613|Chromatiales	135613|Chromatiales	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K16887	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_8
k59_1713908_1	1123229.AUBC01000012_gene2758	4.01e-49	164.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,2U055@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_658173_1	929712.KI912613_gene324	1.26e-30	122.0	COG4221@1|root,COG4221@2|Bacteria,2GN3I@201174|Actinobacteria,4CTH1@84995|Rubrobacteria	84995|Rubrobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1483072_1	656024.FsymDg_4119	3.06e-28	116.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,2GM3U@201174|Actinobacteria,4EUNB@85013|Frankiales	201174|Actinobacteria	S	AAA domain	-	GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009987,GO:0030312,GO:0044464,GO:0044764,GO:0046812,GO:0051704,GO:0071944	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_1538719_1	1035308.AQYY01000001_gene1582	1.12e-77	239.0	COG0637@1|root,COG0637@2|Bacteria	2|Bacteria	S	phosphonoacetaldehyde hydrolase activity	-	-	3.1.3.23	ko:K19270	-	-	-	-	ko00000,ko01000	-	-	-	HAD_2
k59_834654_1	1318628.MARLIPOL_14555	1.63e-15	82.4	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464X3@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_658919_1	397278.JOJN01000018_gene3509	6.29e-40	138.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria,4DNSE@85009|Propionibacteriales	201174|Actinobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_658919_2	196162.Noca_0313	3.43e-32	125.0	COG5002@1|root,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4DP74@85009|Propionibacteriales	201174|Actinobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_1484086_1	1038858.AXBA01000024_gene4001	6.48e-21	87.0	COG5416@1|root,COG5416@2|Bacteria,1PP5Y@1224|Proteobacteria,2VCH5@28211|Alphaproteobacteria,3F037@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Lipopolysaccharide assembly protein A domain	-	-	-	-	-	-	-	-	-	-	-	-	LapA_dom
k59_1484086_2	269796.Rru_A0292	6.65e-47	152.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2UBR5@28211|Alphaproteobacteria,2JT6X@204441|Rhodospirillales	204441|Rhodospirillales	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	ihfB	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_1249047_1	1047013.AQSP01000125_gene2616	1.9e-60	191.0	COG0503@1|root,COG0503@2|Bacteria,2NPGX@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006144,GO:0006166,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042440,GO:0042451,GO:0042455,GO:0043094,GO:0043096,GO:0043101,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046128,GO:0046129,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.10,2.4.2.22,2.4.2.7	ko:K00759,ko:K00762,ko:K03816,ko:K09685	ko00230,ko00240,ko01100,ko01110,map00230,map00240,map01100,map01110	M00051	R00190,R01229,R01870,R02142,R04378	RC00063,RC00122,RC00611	ko00000,ko00001,ko00002,ko01000,ko03000,ko04147	-	-	iYO844.BSU22070	PRTase_2,Pribosyltran,PuR_N,TRSP
k59_130622_1	543913.D521_0711	1.45e-91	287.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2VJ5N@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_21498_1	1502852.FG94_00610	4.49e-45	158.0	COG1230@1|root,COG1230@2|Bacteria,1QUZ5@1224|Proteobacteria,2WGMK@28216|Betaproteobacteria,4764Q@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Cation efflux family	zitB	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Abhydrolase_6,Cation_efflux
k59_189258_1	760192.Halhy_5381	3.44e-07	52.4	2A087@1|root,30NBF@2|Bacteria,4NMD0@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_189258_2	1033730.CAHG01000014_gene1850	5.72e-12	68.9	COG1757@1|root,COG1757@2|Bacteria,2I8CQ@201174|Actinobacteria	201174|Actinobacteria	C	Na H antiporter	nhaC	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
k59_1309979_1	2340.JV46_03550	1.36e-131	392.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1J4RR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tktA	GO:0000302,GO:0003674,GO:0003824,GO:0004802,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009635,GO:0009636,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016740,GO:0016744,GO:0019219,GO:0019222,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0019842,GO:0030145,GO:0030976,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0036245,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046496,GO:0046677,GO:0046872,GO:0046914,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051156,GO:0051171,GO:0051173,GO:0051186,GO:0051252,GO:0051254,GO:0051716,GO:0055086,GO:0060255,GO:0065007,GO:0070301,GO:0070887,GO:0071236,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0072524,GO:0072747,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:1901135,GO:1901322,GO:1901360,GO:1901363,GO:1901562,GO:1901564,GO:1901654,GO:1901655,GO:1901681,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	iECABU_c1320.ECABU_c27750,iLF82_1304.LF82_2271,iNRG857_1313.NRG857_12300,iSDY_1059.SDY_3141,iYL1228.KPN_01127,iYL1228.KPN_02799,ic_1306.c2990	Transket_pyr,Transketolase_C,Transketolase_N
k59_189259_1	94624.Bpet3241	2.61e-83	264.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2VHRH@28216|Betaproteobacteria,3T1KE@506|Alcaligenaceae	28216|Betaproteobacteria	C	cytochrome c oxidase	ccoG	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
k59_1657128_1	1260251.SPISAL_01105	4.11e-12	63.2	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria,1WY42@135613|Chromatiales	135613|Chromatiales	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_1657128_2	160488.PP_5114	3.3e-18	83.6	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria,1YYDF@136845|Pseudomonas putida group	1236|Gammaproteobacteria	L	Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle	rsmD	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
k59_1538729_1	243233.MCA0345	1.15e-91	279.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1XE3A@135618|Methylococcales	135618|Methylococcales	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
k59_1838223_1	118168.MC7420_1742	1.73e-30	117.0	COG3217@1|root,COG3217@2|Bacteria,1G41J@1117|Cyanobacteria,1HA5C@1150|Oscillatoriales	1117|Cyanobacteria	S	Fe-S protein	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
k59_1597099_2	1193181.BN10_760020	2.72e-59	186.0	COG0091@1|root,COG0091@2|Bacteria,2IM3J@201174|Actinobacteria,4FH21@85021|Intrasporangiaceae	201174|Actinobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_1362753_1	563192.HMPREF0179_02739	4.38e-35	136.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2M859@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_1714643_1	194439.CT2213	1.33e-58	193.0	COG0536@1|root,COG0536@2|Bacteria,1FDRR@1090|Chlorobi	1090|Chlorobi	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_1074090_2	1049564.TevJSym_bc00290	1.71e-42	150.0	28JXP@1|root,2Z9N4@2|Bacteria,1MXG4@1224|Proteobacteria,1S2DJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C92
k59_482306_1	247634.GPB2148_2683	6.56e-61	203.0	COG2911@1|root,COG2911@2|Bacteria,1NHQB@1224|Proteobacteria,1SVEG@1236|Gammaproteobacteria,1JC1B@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Porin_2
k59_306071_2	1380394.JADL01000008_gene3453	7.05e-57	179.0	COG3651@1|root,COG3651@2|Bacteria,1RH68@1224|Proteobacteria,2U9D3@28211|Alphaproteobacteria,2JTF9@204441|Rhodospirillales	204441|Rhodospirillales	S	Uncharacterized protein conserved in bacteria (DUF2237)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2237
k59_1187373_1	1120953.AUBH01000001_gene1198	6.57e-95	298.0	COG0366@1|root,COG0366@2|Bacteria,1MU90@1224|Proteobacteria,1RQ1S@1236|Gammaproteobacteria,464Q7@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.135	ko:K21575	-	-	-	-	ko00000,ko01000	-	GH13	-	Alpha-amylase,Cyc-maltodext_C,Cyc-maltodext_N
k59_1838242_1	309807.SRU_1659	9.64e-35	132.0	COG3174@1|root,COG3174@2|Bacteria,4NKP6@976|Bacteroidetes,1FJWC@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
k59_1838242_2	1123401.JHYQ01000038_gene1603	2.16e-26	100.0	COG2138@1|root,COG2138@2|Bacteria,1N00J@1224|Proteobacteria,1SEQ6@1236|Gammaproteobacteria,462KV@72273|Thiotrichales	72273|Thiotrichales	S	CbiX	-	-	4.99.1.4	ko:K03794	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R02864	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	CbiX
k59_21525_1	107636.JQNK01000004_gene829	1.01e-64	243.0	COG1572@1|root,COG2706@1|root,COG2931@1|root,COG3210@1|root,COG3291@1|root,COG1572@2|Bacteria,COG2706@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,DUF5122,HemolysinCabind,Lactonase,Laminin_G_3,Peptidase_M10_C,W_rich_C
k59_482321_1	1343158.SACS_0881	9.05e-45	164.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2TRHK@28211|Alphaproteobacteria,2JQB4@204441|Rhodospirillales	204441|Rhodospirillales	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
k59_599402_1	768671.ThimaDRAFT_3762	3.59e-40	145.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,1WW0E@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_599402_2	1116472.MGMO_12c00030	2.12e-43	149.0	COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,1S11C@1236|Gammaproteobacteria,1XE7W@135618|Methylococcales	135618|Methylococcales	G	6-phosphogluconolactonase	-	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
k59_1422347_1	1049564.TevJSym_ae00910	1.17e-85	263.0	COG0477@1|root,COG2814@2|Bacteria,1MV8D@1224|Proteobacteria,1RNF0@1236|Gammaproteobacteria,1J4TF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1422347_3	1049564.TevJSym_ae00930	1.47e-63	202.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1J4CK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_1838255_1	1265310.CCBD010000007_gene3252	6.54e-21	97.4	COG0596@1|root,COG0596@2|Bacteria,2GNK7@201174|Actinobacteria,235PK@1762|Mycobacteriaceae	201174|Actinobacteria	S	TAP-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
k59_77079_1	582899.Hden_3546	3.95e-64	206.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2TS4C@28211|Alphaproteobacteria,3N6M6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_1657167_1	991905.SL003B_3234	7.22e-93	296.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2TR7V@28211|Alphaproteobacteria,4BP5X@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	DEAD/H associated	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_1074130_1	1713.JOFV01000007_gene2864	1.01e-66	210.0	2B34Q@1|root,2ZK49@2|Bacteria,2I2K1@201174|Actinobacteria,4F1YX@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1597125_1	1120985.AUMI01000014_gene1153	5.78e-86	270.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,4H266@909932|Negativicutes	909932|Negativicutes	C	NADH dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_834701_1	455436.DS989811_gene1950	2.25e-35	138.0	COG4773@1|root,COG4773@2|Bacteria,1MWUQ@1224|Proteobacteria,1SJYF@1236|Gammaproteobacteria,46D7R@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_370616_1	1245471.PCA10_11200	7.12e-27	111.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1YDZF@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Predicted permease YjgP/YjgQ family	lptF	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_658967_1	314278.NB231_05811	1.51e-204	578.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales	135613|Chromatiales	S	modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_1249108_1	1267005.KB911256_gene1940	7.3e-99	295.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,2TRUH@28211|Alphaproteobacteria,3N805@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	HJ	Prokaryotic glutathione synthetase, ATP-grasp domain	rimK	-	6.3.2.32	ko:K05844,ko:K14940	ko00680,ko01120,map00680,map01120	-	R09401	RC00064,RC00090	ko00000,ko00001,ko01000,ko03009	-	-	-	RimK,Zn_protease
k59_834702_1	1304876.AZVC01000001_gene1602	1.9e-45	168.0	COG0739@1|root,COG3055@1|root,COG5492@1|root,COG0739@2|Bacteria,COG3055@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Big_2,Laminin_G_3,Malectin,VCBS
k59_1538764_1	983545.Glaag_3362	4.19e-33	124.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,1RQQT@1236|Gammaproteobacteria,465TH@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
k59_255120_1	1115512.EH105704_10_00210	2.82e-11	63.2	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,3XM9H@561|Escherichia	1236|Gammaproteobacteria	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475	TGT
k59_255120_2	391615.ABSJ01000043_gene2315	7.46e-37	128.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,1S9NV@1236|Gammaproteobacteria,1JB9D@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Preprotein translocase subunit	yajC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
k59_255120_3	998088.B565_2390	1.23e-12	67.4	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1Y3MP@135624|Aeromonadales	135624|Aeromonadales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_423580_2	1121405.dsmv_1422	9.01e-09	53.9	2DUTK@1|root,32UXS@2|Bacteria,1N1IZ@1224|Proteobacteria,42TJU@68525|delta/epsilon subdivisions,2WQQ7@28221|Deltaproteobacteria,2MKSS@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1074159_1	395493.BegalDRAFT_2043	3.42e-26	105.0	COG1075@1|root,COG1075@2|Bacteria,1NXDT@1224|Proteobacteria,1SQ0B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PGAP1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PGAP1
k59_1074159_2	1265505.ATUG01000002_gene1613	9.74e-84	280.0	COG2204@1|root,COG3829@1|root,COG2204@2|Bacteria,COG3829@2|Bacteria,1MU0N@1224|Proteobacteria,43CWU@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_370635_1	56110.Oscil6304_3385	2.14e-32	129.0	COG0515@1|root,COG2199@1|root,COG3899@1|root,COG5002@1|root,COG0515@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,COG5002@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales	2|Bacteria	KLT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,GGDEF,Guanylate_cyc,HATPase_c,HisKA,PAS_9,Pkinase,Response_reg
k59_370635_2	1170562.Cal6303_3567	2.57e-24	104.0	COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4251@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4251@2|Bacteria,1GBKM@1117|Cyanobacteria,1HJ09@1161|Nostocales	1117|Cyanobacteria	KLT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,HATPase_c,HisKA,PAS_3,PAS_9,Pkinase,Response_reg
k59_370635_3	411476.BACOVA_05614	2.17e-11	65.1	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,2FWSR@200643|Bacteroidia,4AV24@815|Bacteroidaceae	976|Bacteroidetes	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
k59_1714689_1	1001240.GY21_04580	9.78e-20	92.4	COG1643@1|root,COG1643@2|Bacteria,2GIWX@201174|Actinobacteria,4FK93@85023|Microbacteriaceae	201174|Actinobacteria	L	Helicase associated domain (HA2)  Add an annotation	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_1838282_1	765914.ThisiDRAFT_0368	1.18e-55	187.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,1WW0U@135613|Chromatiales	135613|Chromatiales	O	HflC and HflK could regulate a protease	-	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_1838282_2	1121035.AUCH01000019_gene2854	1.26e-13	72.8	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,2KUKU@206389|Rhodocyclales	206389|Rhodocyclales	O	HflC and HflK could encode or regulate a protease	-	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
k59_1484177_1	768671.ThimaDRAFT_4579	1.74e-101	310.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1WXJT@135613|Chromatiales	135613|Chromatiales	F	Belongs to the 5'-nucleotidase family	-	-	-	ko:K17224	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	5_nucleotid_C
k59_1310063_1	1385521.N803_08165	2.84e-89	291.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria,4FEMU@85021|Intrasporangiaceae	201174|Actinobacteria	E	MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_773875_1	765912.Thimo_1301	5.5e-146	422.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,1WWZH@135613|Chromatiales	135613|Chromatiales	EH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_1310067_1	1458275.AZ34_07565	1.9e-58	192.0	COG0789@1|root,COG0789@2|Bacteria,1R2NF@1224|Proteobacteria,2VJDG@28216|Betaproteobacteria,4ACBQ@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM regulatory protein, MerR	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
k59_1422382_1	1278078.G419_08916	5.13e-76	238.0	COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria,4FXWF@85025|Nocardiaceae	201174|Actinobacteria	F	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism	add1	GO:0000034,GO:0003674,GO:0003824,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046083,GO:0046100,GO:0046101,GO:0046112,GO:0046113,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
k59_898938_1	105559.Nwat_0767	2.61e-78	245.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1WWD4@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_77126_2	748658.KB907314_gene143	1.15e-29	119.0	COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,1X01D@135613|Chromatiales	135613|Chromatiales	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB	hscA	-	-	ko:K04044	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
k59_306122_2	247633.GP2143_00737	9.57e-92	281.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1J4FD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	COG2951 Membrane-bound lytic murein transglycosylase B	mltB	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
k59_77127_1	1266925.JHVX01000002_gene781	1.67e-38	143.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VJEM@28216|Betaproteobacteria,372NW@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_1126388_1	519989.ECTPHS_07326	4.66e-75	245.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWI3@135613|Chromatiales	135613|Chromatiales	L	PFAM UvrD REP helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1187431_1	1121405.dsmv_0054	1.91e-83	268.0	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria,2MHMN@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_898944_1	1269813.ATUL01000012_gene441	1.26e-67	214.0	COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,1WWM6@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator	-	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
k59_898947_1	1131553.JIBI01000017_gene577	1.17e-90	293.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2VJSI@28216|Betaproteobacteria,372PZ@32003|Nitrosomonadales	28216|Betaproteobacteria	L	RNA polymerase recycling family C-terminal	-	-	-	ko:K03580	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	DUF3883,Helicase_C,RapA_C,ResIII,SNF2_N
k59_77136_1	382640.BT_0074	4.94e-93	289.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2TR3H@28211|Alphaproteobacteria,48T7P@772|Bartonellaceae	28211|Alphaproteobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_306131_1	926564.KI911565_gene5907	7.43e-79	242.0	COG1192@1|root,COG1192@2|Bacteria,2GMU7@201174|Actinobacteria,4F3TJ@85017|Promicromonosporaceae	201174|Actinobacteria	D	AAA domain	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_1597175_1	319795.Dgeo_0621	1.35e-73	243.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1WI6E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1484211_1	887898.HMPREF0551_1640	2.75e-132	392.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,1K0Q5@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM FAD linked oxidase domain protein	glcD	-	1.1.2.4,1.1.3.15,1.1.5.12	ko:K00102,ko:K00104,ko:K03777	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475,R00704,R11591	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_898954_1	1163408.UU9_14220	6.44e-49	163.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,1S5YV@1236|Gammaproteobacteria,1X5ZB@135614|Xanthomonadales	135614|Xanthomonadales	CO	Thiol disulfide interchange protein	ccmG1	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
k59_898954_2	488538.SAR116_0747	4.47e-08	55.1	COG3088@1|root,COG4235@1|root,COG3088@2|Bacteria,COG4235@2|Bacteria,1MZZ5@1224|Proteobacteria,2U96P@28211|Alphaproteobacteria,4BQI7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	subunit of a heme lyase	cycL	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
k59_1484214_1	996306.SSUR61_0046	1.42e-09	59.3	COG0594@1|root,COG0594@2|Bacteria,1VA78@1239|Firmicutes,4HKG6@91061|Bacilli,1WTIW@1307|Streptococcus suis	91061|Bacilli	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0031123,GO:0031404,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
k59_1133163_1	2340.JV46_14280	1.28e-96	294.0	COG1156@1|root,COG1156@2|Bacteria,1QUQE@1224|Proteobacteria,1T210@1236|Gammaproteobacteria,1JC0C@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_ab
k59_1722052_1	566466.NOR53_631	1.06e-127	381.0	COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,1J5ZV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	COG2303 Choline dehydrogenase and related flavoproteins	-	-	1.1.99.3	ko:K06151	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
k59_1084273_1	1458427.BAWN01000028_gene1625	5.39e-58	208.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4A9PA@80864|Comamonadaceae	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,MASE3,PAS,PAS_4,PAS_9
k59_1084273_2	1122604.JONR01000003_gene1503	1.68e-07	54.3	COG1352@1|root,COG2201@1|root,COG4585@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG4585@2|Bacteria,1NQTI@1224|Proteobacteria,1T45F@1236|Gammaproteobacteria,1XD8B@135614|Xanthomonadales	135614|Xanthomonadales	NT	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,PAS_10,PAS_4
k59_1320297_1	1114970.PSF113_1517	1.01e-71	242.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,1YM1S@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	M	Patatin-like phospholipase	plpD	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k59_724561_1	243090.RB5821	1.87e-24	103.0	COG0738@1|root,COG0738@2|Bacteria,2J1RM@203682|Planctomycetes	203682|Planctomycetes	G	Major Facilitator Superfamily	-	-	-	ko:K02429	-	-	-	-	ko00000,ko02000	2.A.1.7	-	-	MFS_1
k59_724561_2	80884.CCF46867	4.87e-28	104.0	COG4154@1|root,2RZR7@2759|Eukaryota,3A1QW@33154|Opisthokonta,3PV62@4751|Fungi,3R4TA@4890|Ascomycota,21KQF@147550|Sordariomycetes,1F2GN@1028384|Glomerellales	4751|Fungi	G	RbsD FucU transporter	-	-	-	-	-	-	-	-	-	-	-	-	RbsD_FucU
k59_313647_1	1219581.HMPREF1628_03825	7.91e-59	205.0	COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,4D4GH@85005|Actinomycetales	201174|Actinobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
k59_666128_1	335543.Sfum_3923	1.03e-149	445.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,2MRI6@213462|Syntrophobacterales	28221|Deltaproteobacteria	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_87246_1	713586.KB900536_gene2898	1.45e-99	301.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales	135613|Chromatiales	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
k59_1014928_2	472759.Nhal_0931	4.24e-37	130.0	COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,1WXZ5@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0234 family	-	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
k59_137892_1	1304888.ATWF01000002_gene305	1.26e-92	278.0	COG1741@1|root,COG1741@2|Bacteria	2|Bacteria	O	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
k59_1084283_1	765912.Thimo_3702	3e-53	184.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1WWKE@135613|Chromatiales	135613|Chromatiales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_196466_1	1280948.HY36_16455	3.73e-58	200.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,43X6D@69657|Hyphomonadaceae	28211|Alphaproteobacteria	CG	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
k59_1604140_1	1223521.BBJX01000002_gene2861	2e-74	233.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VM89@28216|Betaproteobacteria,4AHA1@80864|Comamonadaceae	28216|Betaproteobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	-	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_1604140_2	1123360.thalar_02885	1.55e-136	405.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2U068@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_489579_1	765911.Thivi_3675	5.48e-161	465.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1WWPJ@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
k59_265826_1	446470.Snas_3840	2.44e-40	149.0	COG0436@1|root,COG0436@2|Bacteria,2I9CX@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase class I and II	-	-	4.1.1.12	ko:K09758	ko00250,ko00270,ko01100,ko01230,map00250,map00270,map01100,map01230	-	R00397,R00863	RC00282,RC00399,RC00400	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
k59_780046_2	1442599.JAAN01000005_gene929	4.62e-66	223.0	COG3213@1|root,COG3213@2|Bacteria,1PJXJ@1224|Proteobacteria,1S4J4@1236|Gammaproteobacteria,1X3TN@135614|Xanthomonadales	135614|Xanthomonadales	P	protein involved in response to NO	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
k59_1492998_1	522306.CAP2UW1_3551	8.12e-57	185.0	COG2191@1|root,COG2191@2|Bacteria,1RD60@1224|Proteobacteria,2VR8B@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Formylmethanofuran dehydrogenase, subunit e	-	-	-	-	-	-	-	-	-	-	-	-	FmdE
k59_1546007_1	1123401.JHYQ01000046_gene2202	2.3e-19	87.8	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,45ZNH@72273|Thiotrichales	72273|Thiotrichales	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
k59_1546007_2	396588.Tgr7_1388	4.02e-110	329.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1WX07@135613|Chromatiales	135613|Chromatiales	M	PFAM Cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_32064_1	1121396.KB893100_gene4319	2.08e-58	204.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2
k59_1492999_1	1349820.M707_07825	1.16e-19	90.1	COG5617@1|root,COG5617@2|Bacteria,2HKW0@201174|Actinobacteria,1W929@1268|Micrococcaceae	201174|Actinobacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1492999_2	590998.Celf_1857	6.48e-120	369.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4F0M6@85016|Cellulomonadaceae	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_666142_1	1379698.RBG1_1C00001G1816	6.32e-28	117.0	COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,2NR9R@2323|unclassified Bacteria	2|Bacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,PMT_2,TPR_8
k59_196475_1	292415.Tbd_2730	5.89e-51	183.0	COG0129@1|root,COG0676@1|root,COG0129@2|Bacteria,COG0676@2|Bacteria,1MUTQ@1224|Proteobacteria,2VH5Q@28216|Betaproteobacteria,1KS6Q@119069|Hydrogenophilales	119069|Hydrogenophilales	EG	Dehydratase family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim,ILVD_EDD
k59_1722085_1	876044.IMCC3088_810	1.52e-24	108.0	COG4733@1|root,COG4733@2|Bacteria,1R55I@1224|Proteobacteria,1S5X2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1664658_1	768670.Calni_1864	2.54e-08	56.6	COG4191@1|root,COG4191@2|Bacteria,2GFSX@200930|Deferribacteres	200930|Deferribacteres	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_1664658_2	1267005.KB911261_gene2326	1.1e-24	101.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2TUND@28211|Alphaproteobacteria,3N8RA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K14987	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_32078_1	1410634.JHVD01000002_gene146	1.24e-42	152.0	COG0010@1|root,COG0010@2|Bacteria,2IA0Q@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide	hutG	-	3.5.3.8	ko:K01479	ko00340,ko01100,map00340,map01100	M00045	R02285	RC00221,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
k59_32078_2	765952.PUV_00830	4.83e-16	79.3	COG0861@1|root,COG0861@2|Bacteria,2JGY6@204428|Chlamydiae	204428|Chlamydiae	P	Integral membrane protein TerC family	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
k59_909132_1	1415778.JQMM01000001_gene2175	8.64e-209	586.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1J56Y@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	-	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_909132_2	1415778.JQMM01000001_gene2176	1.48e-53	172.0	COG0355@1|root,COG0355@2|Bacteria,1N1NE@1224|Proteobacteria,1S9B5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	epsilon subunit	-	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
k59_430761_1	765911.Thivi_0700	1.71e-30	120.0	28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,1RQ1H@1236|Gammaproteobacteria,1WXBU@135613|Chromatiales	135613|Chromatiales	P	Cytochrome c bacterial	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_cB
k59_430761_2	519989.ECTPHS_04119	2.17e-63	199.0	COG4117@1|root,COG4117@2|Bacteria,1R5GN@1224|Proteobacteria,1S54N@1236|Gammaproteobacteria,1WVV7@135613|Chromatiales	135613|Chromatiales	C	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_1258482_1	1380354.JIAN01000005_gene2284	2.16e-20	82.4	2EMYX@1|root,33FM2@2|Bacteria,2GZ6D@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_606813_1	640511.BC1002_0029	2.12e-07	53.5	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2VI4V@28216|Betaproteobacteria,1K1JQ@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
k59_33540_2	1123377.AUIV01000010_gene2210	1.89e-06	48.1	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,1X6GB@135614|Xanthomonadales	135614|Xanthomonadales	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
k59_267192_1	396588.Tgr7_0769	1.83e-42	151.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1WWB9@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_267192_2	519989.ECTPHS_01879	5.92e-119	354.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1WW6B@135613|Chromatiales	135613|Chromatiales	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_490335_2	1123065.ATWL01000001_gene504	1.94e-101	315.0	COG0389@1|root,COG0389@2|Bacteria,2GMZ3@201174|Actinobacteria	201174|Actinobacteria	L	Nucleotidyltransferase DNA polymerase involved in DNA repair	dinB_2	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
k59_842804_1	697282.Mettu_0353	8.88e-93	277.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,1RP1N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_607602_1	176652.261R_IIV6	2.58e-40	152.0	4QGKQ@10239|Viruses,4QYNE@35237|dsDNA viruses  no RNA stage	10239|Viruses	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1133938_1	498761.HM1_2630	1.42e-11	64.7	COG1304@1|root,COG1304@2|Bacteria,1TPC5@1239|Firmicutes,247PK@186801|Clostridia	186801|Clostridia	C	'glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
k59_1133938_2	1150399.AQYK01000002_gene2895	6.97e-28	116.0	COG1472@1|root,COG1472@2|Bacteria,2GM43@201174|Actinobacteria,4FMBI@85023|Microbacteriaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
k59_910346_1	335543.Sfum_0901	2.65e-58	196.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,42PRT@68525|delta/epsilon subdivisions,2WIWH@28221|Deltaproteobacteria,2MRDP@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2638	PEPCK_C,PEPCK_N
k59_1493944_1	631362.Thi970DRAFT_02291	4.07e-88	281.0	COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,1WWRD@135613|Chromatiales	135613|Chromatiales	M	HAD-superfamily hydrolase, subfamily IIB	-	-	2.4.1.14	ko:K00696	ko00500,ko01100,map00500,map01100	-	R00766	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth
k59_780704_1	395493.BegalDRAFT_0244	4.55e-65	223.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RMPV@1236|Gammaproteobacteria,4606X@72273|Thiotrichales	72273|Thiotrichales	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_490351_1	794903.OPIT5_08720	2.12e-52	177.0	COG1864@1|root,COG1864@2|Bacteria,46XZ1@74201|Verrucomicrobia,3K8NB@414999|Opitutae	414999|Opitutae	F	DNA/RNA non-specific endonuclease	-	-	-	ko:K01173	ko04210,map04210	-	-	-	ko00000,ko00001,ko03029	-	-	-	Endonuclease_NS
k59_969352_1	1095767.CAHD01000071_gene3099	7.53e-60	209.0	COG0577@1|root,COG0577@2|Bacteria,2GJTZ@201174|Actinobacteria,4F1V7@85016|Cellulomonadaceae	201174|Actinobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_725358_2	880072.Desac_0388	5.32e-91	285.0	COG2203@1|root,COG2206@1|root,COG3437@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3437@2|Bacteria,1MV37@1224|Proteobacteria,42N4N@68525|delta/epsilon subdivisions,2WKJ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD,HD_5
k59_1259505_1	519989.ECTPHS_07586	3.92e-176	514.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1WVZ4@135613|Chromatiales	135613|Chromatiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_1259505_2	713586.KB900536_gene2142	8.94e-22	95.9	COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,1RN5P@1236|Gammaproteobacteria,1WYPF@135613|Chromatiales	135613|Chromatiales	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	AAA_23,SMC_N
k59_138638_2	648757.Rvan_0592	3.82e-59	199.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria,3N9EG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,Pyr_redox_2
k59_33592_2	1449058.JQKT01000009_gene189	1.25e-55	187.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
k59_1321602_1	545264.KB898744_gene2024	6.92e-26	104.0	COG3065@1|root,COG3065@2|Bacteria,1MZ8C@1224|Proteobacteria,1S9UB@1236|Gammaproteobacteria,1WYVZ@135613|Chromatiales	135613|Chromatiales	M	PFAM Outer membrane lipoprotein Slp	-	-	-	ko:K07285	-	-	-	-	ko00000	-	-	-	Slp
k59_1321602_2	1234364.AMSF01000037_gene127	3.72e-16	77.0	COG3065@1|root,COG3065@2|Bacteria,1MZ8C@1224|Proteobacteria,1S9UB@1236|Gammaproteobacteria,1X64R@135614|Xanthomonadales	135614|Xanthomonadales	M	Outer membrane lipoprotein	slp	-	-	ko:K07285	-	-	-	-	ko00000	-	-	-	Slp
k59_725362_1	1123392.AQWL01000008_gene1239	4.44e-21	93.2	COG4447@1|root,COG4447@2|Bacteria,1NRDC@1224|Proteobacteria,2VM3D@28216|Betaproteobacteria	28216|Betaproteobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
k59_725362_2	1123392.AQWL01000008_gene1238	3.03e-28	113.0	COG3292@1|root,COG3292@2|Bacteria,1QMJ4@1224|Proteobacteria,2VNHI@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
k59_842829_1	1380390.JIAT01000010_gene4832	1.04e-102	320.0	COG1185@1|root,COG1185@2|Bacteria,2GIT2@201174|Actinobacteria,4CPRU@84995|Rubrobacteria	84995|Rubrobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_1849822_1	1122599.AUGR01000029_gene3059	4.01e-38	144.0	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,1RMC2@1236|Gammaproteobacteria,1XITF@135619|Oceanospirillales	135619|Oceanospirillales	T	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	-	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
k59_1133952_1	870187.Thini_0893	1.58e-49	170.0	COG0584@1|root,COG0584@2|Bacteria,1MVWZ@1224|Proteobacteria,1RRBP@1236|Gammaproteobacteria,461RS@72273|Thiotrichales	72273|Thiotrichales	C	Glycerophosphoryl diester phosphodiesterase family	-	-	-	-	-	-	-	-	-	-	-	-	GDPD
k59_666901_1	1335757.SPICUR_01560	7.86e-60	194.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1WWA7@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_666901_2	1117647.M5M_12705	1.3e-05	47.4	COG3161@1|root,COG3161@2|Bacteria,1N8BF@1224|Proteobacteria,1SDX2@1236|Gammaproteobacteria,1J6IV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway	ubiC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008813,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.1.3.40	ko:K03181	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R01302	RC00491,RC02148	ko00000,ko00001,ko00002,ko01000	-	-	iZ_1308.Z5638	Chor_lyase
k59_1665538_1	1267005.KB911257_gene758	4.37e-122	358.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TQYV@28211|Alphaproteobacteria,3N65J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabB	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1015633_1	1306174.JODP01000002_gene5962	8.07e-32	124.0	COG3879@1|root,COG3879@2|Bacteria,2GMS5@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF881
k59_1321628_1	926549.KI421517_gene463	3.03e-54	187.0	COG2234@1|root,COG2234@2|Bacteria,4NFDJ@976|Bacteroidetes,47KZX@768503|Cytophagia	976|Bacteroidetes	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_969391_1	367299.JOEE01000007_gene233	2.68e-84	264.0	COG4346@1|root,COG4346@2|Bacteria,2GITT@201174|Actinobacteria,4FEHH@85021|Intrasporangiaceae	201174|Actinobacteria	O	membrane	pmt	GO:0000030,GO:0003674,GO:0003824,GO:0006464,GO:0006486,GO:0006493,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0019538,GO:0034645,GO:0035268,GO:0035269,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0070085,GO:0071704,GO:0097502,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	PMT,PMT_2,PMT_4TMC
k59_780726_1	511062.GU3_10515	3.78e-43	142.0	2EN3K@1|root,33FRP@2|Bacteria,1NHFH@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1015635_1	1454010.JEOE01000009_gene3100	1.13e-41	147.0	2E1BJ@1|root,32WRF@2|Bacteria,2I7ZD@201174|Actinobacteria,4F2QZ@85016|Cellulomonadaceae	201174|Actinobacteria	S	LytR cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C
k59_431567_1	1035308.AQYY01000001_gene1763	2.4e-66	217.0	COG2252@1|root,COG2252@2|Bacteria,1TQC6@1239|Firmicutes,2483Q@186801|Clostridia,2605B@186807|Peptococcaceae	186801|Clostridia	S	PFAM Xanthine uracil vitamin C permease	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
k59_910411_1	109760.SPPG_04975T0	1.55e-16	76.6	COG0509@1|root,KOG3373@2759|Eukaryota,3A5U5@33154|Opisthokonta,3P4M7@4751|Fungi	4751|Fungi	E	The H protein shuttles the methylamine group of glycine from the P protein to the T protein	GCV3	GO:0001505,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005960,GO:0006082,GO:0006464,GO:0006520,GO:0006544,GO:0006546,GO:0006730,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009249,GO:0009987,GO:0010467,GO:0016054,GO:0017144,GO:0018065,GO:0018193,GO:0018205,GO:0019464,GO:0019538,GO:0019752,GO:0032991,GO:0036211,GO:0042133,GO:0042135,GO:0042737,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044267,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0051604,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
k59_910411_2	1123252.ATZF01000002_gene2464	1.89e-62	203.0	COG0745@1|root,COG0745@2|Bacteria,1U3FH@1239|Firmicutes,4HF9S@91061|Bacilli,27BIW@186824|Thermoactinomycetaceae	91061|Bacilli	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_1781329_1	411684.HPDFL43_08154	1.38e-85	265.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,43GQQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.76	ko:K15785	ko00260,map00260	-	R06977	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
k59_1849870_1	1121451.DESAM_20607	2.66e-41	151.0	COG0642@1|root,COG2205@2|Bacteria,1QHXX@1224|Proteobacteria,42NW1@68525|delta/epsilon subdivisions,2WJUF@28221|Deltaproteobacteria,2M85B@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_88591_1	446471.Xcel_2450	3.38e-214	604.0	COG0056@1|root,COG0056@2|Bacteria,2GJRJ@201174|Actinobacteria,4F3VK@85017|Promicromonosporaceae	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_1604930_1	930171.Asphe3_21340	2.83e-41	146.0	2E9HK@1|root,333QQ@2|Bacteria,2GPQ1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1604930_2	1068978.AMETH_3649	6.25e-48	169.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria,4E11F@85010|Pseudonocardiales	201174|Actinobacteria	KOT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1321651_1	396588.Tgr7_0696	5.03e-78	248.0	COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1WWFZ@135613|Chromatiales	135613|Chromatiales	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase
k59_1015645_1	1380393.JHVP01000004_gene649	1.37e-32	115.0	COG2026@1|root,COG2026@2|Bacteria,2GRQR@201174|Actinobacteria,4EW7V@85013|Frankiales	201174|Actinobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
k59_725385_2	1123073.KB899241_gene2514	1.96e-152	455.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,1X30I@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
k59_1085311_1	1121413.JMKT01000009_gene1921	8.07e-35	133.0	COG0569@1|root,COG1226@1|root,COG0569@2|Bacteria,COG1226@2|Bacteria,1R4J8@1224|Proteobacteria,42NKU@68525|delta/epsilon subdivisions,2WIRH@28221|Deltaproteobacteria,2M9MG@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Ion transport 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_C,TrkA_N
k59_1133983_1	76114.ebA594	1.58e-75	230.0	COG0221@1|root,COG0221@2|Bacteria,1RGCP@1224|Proteobacteria,2VRVG@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Inorganic pyrophosphatase	-	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
k59_1133983_2	237368.SCABRO_02564	6.49e-40	150.0	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,2IZEZ@203682|Planctomycetes	203682|Planctomycetes	S	Memo-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AMMECR1,Memo
k59_548977_1	367299.JOEE01000001_gene1539	7.97e-106	316.0	COG2235@1|root,COG2235@2|Bacteria,2GJTR@201174|Actinobacteria,4FG0C@85021|Intrasporangiaceae	201174|Actinobacteria	E	Amidinotransferase	arcA	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
k59_1849898_1	378806.STAUR_3381	2.86e-39	148.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,2YU5Y@29|Myxococcales	28221|Deltaproteobacteria	M	Penicillin-binding Protein dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928	PBP_dimer,Transpeptidase
k59_842878_1	1294273.roselon_00818	3.29e-11	65.1	COG5360@1|root,COG5360@2|Bacteria,1MUJ4@1224|Proteobacteria,2TR5G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Heparinase II III family protein	MA20_25080	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III
k59_1020325_2	765911.Thivi_3325	8.44e-08	52.8	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1WX83@135613|Chromatiales	135613|Chromatiales	S	PFAM YicC-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
k59_274918_1	1232437.KL662030_gene2453	6.51e-106	320.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42MAI@68525|delta/epsilon subdivisions,2WJ8M@28221|Deltaproteobacteria,2MHXE@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_144265_1	1049564.TevJSym_cb00050	1.61e-198	575.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1J6D9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin,Thioredoxin_7
k59_1331835_1	999547.KI421500_gene3579	2.08e-141	423.0	COG0123@1|root,COG0454@1|root,COG0123@2|Bacteria,COG0456@2|Bacteria,1MU7P@1224|Proteobacteria,2TRRH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	BQ	COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein	aphA	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_1091769_1	1448139.AI20_11700	1.37e-109	349.0	COG0479@1|root,COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0479@2|Bacteria,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1Y4PX@135624|Aeromonadales	135624|Aeromonadales	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1091769_2	1469245.JFBG01000019_gene1134	1.04e-163	462.0	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,1SBBX@1236|Gammaproteobacteria,1X060@135613|Chromatiales	135613|Chromatiales	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_202821_1	1713.JOFV01000013_gene1002	2.12e-57	201.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4F0IU@85016|Cellulomonadaceae	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1436307_1	685778.AORL01000022_gene1674	5.58e-96	295.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2TSJ5@28211|Alphaproteobacteria,2K2R1@204457|Sphingomonadales	204457|Sphingomonadales	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
k59_672520_1	266265.Bxe_C0490	1.97e-40	146.0	COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2VWYN@28216|Betaproteobacteria,1K8UX@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	Transposase_20
k59_1020330_2	1177179.A11A3_13555	2.22e-74	234.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,1XH47@135619|Oceanospirillales	135619|Oceanospirillales	IQ	reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_392183_1	1177179.A11A3_12880	9.9e-36	125.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,1S8Z7@1236|Gammaproteobacteria,1XKHN@135619|Oceanospirillales	135619|Oceanospirillales	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
k59_392183_2	1121943.KB899989_gene3171	1.5e-47	170.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1XHDW@135619|Oceanospirillales	135619|Oceanospirillales	O	Belongs to the ClpA ClpB family	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1331855_1	1185876.BN8_04330	1.09e-62	217.0	COG2866@1|root,COG2866@2|Bacteria,4NF3D@976|Bacteroidetes,47MVZ@768503|Cytophagia	976|Bacteroidetes	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_392184_1	1260251.SPISAL_03105	4.48e-51	167.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,1S2ET@1236|Gammaproteobacteria,1WWDD@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_98723_1	1304865.JAGF01000001_gene1993	7.43e-60	199.0	COG1299@1|root,COG1445@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,2GJU4@201174|Actinobacteria	201174|Actinobacteria	GT	Phosphotransferase System	fruA	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2,PTS_EIIC,PTS_IIB
k59_144282_1	321846.PS417_12310	8.96e-25	103.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_144282_2	663610.JQKO01000025_gene254	9.29e-36	130.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2TQZA@28211|Alphaproteobacteria,3NAC1@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	Methylenetetrahydrofolate reductase	metF	GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
k59_98726_1	232346.JHQL01000004_gene1860	9.86e-137	433.0	COG0591@1|root,COG0784@1|root,COG2202@1|root,COG3829@1|root,COG4191@1|root,COG0591@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria,1XH3H@135619|Oceanospirillales	135619|Oceanospirillales	T	COG0591 Na proline symporter	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_7,Response_reg,SSF
k59_1860158_1	177437.HRM2_11590	4.64e-24	93.2	COG0298@1|root,COG0298@2|Bacteria,1N76Y@1224|Proteobacteria,42X24@68525|delta/epsilon subdivisions,2WSTX@28221|Deltaproteobacteria,2MM25@213118|Desulfobacterales	28221|Deltaproteobacteria	O	TIGRFAM hydrogenase assembly chaperone hypC hupF	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
k59_1860158_2	177437.HRM2_22370	6.68e-37	129.0	COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,42REH@68525|delta/epsilon subdivisions,2WP4D@28221|Deltaproteobacteria,2MKC0@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Hydrogenase maturation protease	hybD	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
k59_1091792_1	1906.SFRA_24355	6.58e-106	319.0	COG0402@1|root,COG0402@2|Bacteria,2GNUN@201174|Actinobacteria	201174|Actinobacteria	F	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_672533_1	1249627.D779_4167	1.23e-10	62.8	COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,1SYJC@1236|Gammaproteobacteria,1WW83@135613|Chromatiales	135613|Chromatiales	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1728672_1	56780.SYN_01419	1.45e-37	139.0	COG0301@1|root,COG1293@1|root,COG0301@2|Bacteria,COG1293@2|Bacteria,1N1R1@1224|Proteobacteria,42MQ9@68525|delta/epsilon subdivisions,2WJPN@28221|Deltaproteobacteria,2MR7P@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Domain of unknown function (DUF814)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,ThiI
k59_731118_1	887327.HMPREF0476_0756	1.26e-05	46.2	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2VI24@28216|Betaproteobacteria,2KQ8Y@206351|Neisseriales	206351|Neisseriales	M	Belongs to the SIS family. GutQ KpsF subfamily	kdsD	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
k59_731118_2	768671.ThimaDRAFT_1391	5.55e-85	254.0	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,1WY5Q@135613|Chromatiales	135613|Chromatiales	S	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate	-	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
k59_274960_1	313612.L8106_23510	6.23e-138	415.0	COG0058@1|root,COG0058@2|Bacteria,1FZUX@1117|Cyanobacteria,1H71S@1150|Oscillatoriales	1117|Cyanobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_1020341_1	448385.sce3427	1.21e-11	68.2	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,42NS6@68525|delta/epsilon subdivisions,2WKYJ@28221|Deltaproteobacteria,2YU4P@29|Myxococcales	28221|Deltaproteobacteria	H	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_1020341_2	575540.Isop_1994	1.59e-15	78.2	COG0297@1|root,COG0297@2|Bacteria,2IX7T@203682|Planctomycetes	203682|Planctomycetes	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_1552141_1	237368.SCABRO_01271	1.35e-105	326.0	COG0326@1|root,COG0326@2|Bacteria,2IYC7@203682|Planctomycetes	203682|Planctomycetes	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c_3,HSP90
k59_731121_1	765910.MARPU_16450	2.98e-74	234.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1WX4M@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_41794_1	631362.Thi970DRAFT_03495	1.89e-13	66.2	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,1S9AB@1236|Gammaproteobacteria,1WYTV@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
k59_41794_2	1120999.JONM01000010_gene4105	1.41e-34	133.0	COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,2VKA1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_274969_1	1385518.N798_10145	5.82e-96	285.0	COG0852@1|root,COG0852@2|Bacteria,2GIRH@201174|Actinobacteria,4FENN@85021|Intrasporangiaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_1020346_2	1227261.HMPREF0043_00977	9.37e-16	76.3	COG0561@1|root,COG0561@2|Bacteria,2GP42@201174|Actinobacteria,4D461@85005|Actinomycetales	201174|Actinobacteria	S	HAD hydrolase, family IIB	yidA	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
k59_920595_1	395965.Msil_1521	3.79e-10	63.9	COG1999@1|root,COG1999@2|Bacteria,1N5E3@1224|Proteobacteria	1224|Proteobacteria	S	protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
k59_1552149_1	396588.Tgr7_0495	1.35e-73	230.0	COG1897@1|root,COG1897@2|Bacteria,1MV64@1224|Proteobacteria,1RM7T@1236|Gammaproteobacteria,1WWUS@135613|Chromatiales	135613|Chromatiales	E	Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	metAS	-	2.3.1.46	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	M00017	R01777	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	HTS
k59_1552149_2	472759.Nhal_1513	2.34e-55	181.0	COG1132@1|root,COG1132@2|Bacteria,1MX5V@1224|Proteobacteria,1RY02@1236|Gammaproteobacteria,1WXG2@135613|Chromatiales	135613|Chromatiales	V	(ABC) transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_202856_1	1125863.JAFN01000001_gene3126	3.16e-43	155.0	COG5659@1|root,COG5659@2|Bacteria,1MWAV@1224|Proteobacteria,43BD6@68525|delta/epsilon subdivisions,2X6S2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_1671251_1	83406.HDN1F_30750	1.91e-10	61.2	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4KP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	glnG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1671251_2	768671.ThimaDRAFT_2575	6.9e-98	301.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1WWFQ@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
k59_1610305_1	888439.HMPREF9240_01378	2.09e-11	64.7	COG1165@1|root,COG1165@2|Bacteria,2GMEB@201174|Actinobacteria,4D310@85005|Actinomycetales	201174|Actinobacteria	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
k59_1610305_2	446469.Sked_07320	9.14e-33	124.0	COG4948@1|root,COG4948@2|Bacteria,2GJJR@201174|Actinobacteria	201174|Actinobacteria	M	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	GO:0008150,GO:0040007	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0553	MR_MLE_C
k59_437309_1	765914.ThisiDRAFT_0193	6.01e-31	111.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,1SCXX@1236|Gammaproteobacteria,1WYUA@135613|Chromatiales	135613|Chromatiales	G	Phosphotransferase System	-	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
k59_437309_2	105559.Nwat_0290	1.56e-38	134.0	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,1SA62@1236|Gammaproteobacteria,1WYYD@135613|Chromatiales	135613|Chromatiales	G	system, fructose subfamily IIA component	-	-	2.7.1.194	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	M00283,M00550	R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.7.1	-	-	EIIA-man
k59_848477_1	649743.HMPREF0972_02516	1.24e-41	147.0	COG0498@1|root,COG0498@2|Bacteria,2GJ5F@201174|Actinobacteria,4D48E@85005|Actinomycetales	201174|Actinobacteria	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_848477_2	935839.JAGJ01000002_gene758	3.7e-29	115.0	COG0460@1|root,COG0460@2|Bacteria,2GIX9@201174|Actinobacteria,4F3XA@85017|Promicromonosporaceae	201174|Actinobacteria	E	Homoserine dehydrogenase	hom	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.1.1.3,2.7.2.4	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1294	ACT,Homoserine_dh,NAD_binding_3
k59_437311_1	880072.Desac_2814	9.68e-104	315.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2MQFX@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta)	-	-	2.1.3.1,2.1.3.15,6.4.1.3	ko:K01966,ko:K17489	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R00353,R01859	RC00040,RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1376216_1	998674.ATTE01000001_gene588	5.7e-09	57.0	COG1100@1|root,COG1100@2|Bacteria,1R1W9@1224|Proteobacteria,1SK3H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF697,MMR_HSR1
k59_1376216_2	1183438.GKIL_2577	2.72e-23	94.0	COG3695@1|root,COG3695@2|Bacteria,1G82G@1117|Cyanobacteria	1117|Cyanobacteria	L	Methylated dna-protein cysteine methyltransferase	-	-	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
k59_1728701_1	1172188.KB911820_gene2104	2.23e-27	105.0	COG3427@1|root,COG3427@2|Bacteria,2HXJU@201174|Actinobacteria,4FH7T@85021|Intrasporangiaceae	201174|Actinobacteria	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
k59_1728701_2	1150399.AQYK01000002_gene3707	2.65e-45	148.0	COG0346@1|root,COG0346@2|Bacteria,2IQB4@201174|Actinobacteria,4FPU2@85023|Microbacteriaceae	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_320244_1	502025.Hoch_4234	6.82e-103	325.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2YYYV@29|Myxococcales	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_1201271_1	1279017.AQYJ01000028_gene2040	1.11e-39	142.0	2DBVC@1|root,2ZBAF@2|Bacteria,1PT3T@1224|Proteobacteria,1RZJK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Psort location CytoplasmicMembrane, score 9.46	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_202870_1	555779.Dthio_PD1145	1.14e-63	202.0	COG0207@1|root,COG0207@2|Bacteria,1Q4ZG@1224|Proteobacteria,42QWZ@68525|delta/epsilon subdivisions,2WMY5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Thymidylate synthase	-	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
k59_1436356_1	1122933.JNIY01000003_gene814	8.98e-120	352.0	COG0012@1|root,COG0012@2|Bacteria,2GIXI@201174|Actinobacteria,4F0JY@85016|Cellulomonadaceae	201174|Actinobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_920633_1	1380354.JIAN01000006_gene552	6.35e-12	62.4	COG3856@1|root,COG3856@2|Bacteria,2IKJW@201174|Actinobacteria,4F1AZ@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1290)	sbp	-	-	-	-	-	-	-	-	-	-	-	DUF1290
k59_1331946_1	1267005.KB911262_gene3325	1.46e-15	73.6	COG0778@1|root,COG0778@2|Bacteria,1R9VX@1224|Proteobacteria,2U5B0@28211|Alphaproteobacteria,3N7J1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NADH dehydrogenase NAD(P)H nitroreductase	rutE	-	-	ko:K09019	ko00240,ko01100,map00240,map01100	-	R09289	RC00087	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
k59_1331946_2	1267005.KB911262_gene3324	3.84e-95	280.0	COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,2TUD1@28211|Alphaproteobacteria,3N6NK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Scaffold protein Nfu NifU	nifU	-	-	-	-	-	-	-	-	-	-	-	Nfu_N,NifU
k59_437319_1	187272.Mlg_2223	4.86e-128	371.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1WW98@135613|Chromatiales	135613|Chromatiales	Q	PFAM ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_672572_1	525904.Tter_1089	2.45e-54	191.0	COG1472@1|root,COG1472@2|Bacteria,2NNZB@2323|unclassified Bacteria	2|Bacteria	G	Glycoside hydrolase family 3 domain protein	bxlA	-	3.2.1.21	ko:K05349,ko:K17641	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_392275_1	395965.Msil_1355	9e-40	145.0	28HJ1@1|root,2Z7UB@2|Bacteria,1R3FN@1224|Proteobacteria,2U1R7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1671269_2	391615.ABSJ01000022_gene301	4.34e-54	178.0	COG3219@1|root,COG3219@2|Bacteria,1R8C9@1224|Proteobacteria,1S23S@1236|Gammaproteobacteria,1J6PK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09929	-	-	-	-	ko00000	-	-	-	DUF2063
k59_731763_1	323850.Shew_0985	1.34e-84	275.0	COG1502@1|root,COG1502@2|Bacteria,1NVR8@1224|Proteobacteria	1224|Proteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_275916_2	998674.ATTE01000001_gene3074	2.32e-52	172.0	COG0702@1|root,COG0702@2|Bacteria,1PD2B@1224|Proteobacteria,1RPIQ@1236|Gammaproteobacteria,4621M@72273|Thiotrichales	72273|Thiotrichales	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
k59_1861256_1	760568.Desku_0165	1.29e-28	116.0	COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,263X9@186807|Peptococcaceae	186801|Clostridia	C	Iron-containing alcohol dehydrogenase	-	-	-	ko:K19954	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
k59_980771_1	1165096.ARWF01000001_gene2054	8.45e-75	241.0	COG0548@1|root,COG1246@1|root,COG1396@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,COG1396@2|Bacteria,1MUUP@1224|Proteobacteria,2VGZC@28216|Betaproteobacteria,2KKM3@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	-	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Acetyltransf_1,HTH_31
k59_203495_1	1122603.ATVI01000005_gene3496	4.29e-49	178.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9IC@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_613922_1	1125973.JNLC01000014_gene2345	2.99e-49	172.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2U2UG@28211|Alphaproteobacteria,3JWWV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c
k59_1376812_1	593907.Celgi_0973	6.54e-63	219.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GM2E@201174|Actinobacteria,4F10D@85016|Cellulomonadaceae	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD2	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1266716_1	1043493.BBLU01000004_gene2539	4.17e-54	186.0	COG1808@1|root,COG1808@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
k59_144926_1	471853.Bcav_2609	1.58e-108	320.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1020863_2	1121405.dsmv_2513	4e-46	160.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,42S0M@68525|delta/epsilon subdivisions,2WNYE@28221|Deltaproteobacteria,2MMEA@213118|Desulfobacterales	28221|Deltaproteobacteria	S	alpha/beta hydrolase fold	yheT	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1332978_1	926569.ANT_01020	6.14e-53	181.0	COG3464@1|root,COG3464@2|Bacteria,2G9B1@200795|Chloroflexi	200795|Chloroflexi	L	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
k59_849072_1	177437.HRM2_33940	1.47e-69	229.0	COG5421@1|root,COG5421@2|Bacteria,1R25F@1224|Proteobacteria,433HE@68525|delta/epsilon subdivisions,2WYHG@28221|Deltaproteobacteria,2MP7M@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Domain of unknown function (DUF4277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4277
k59_1266731_1	1158292.JPOE01000002_gene1439	5.47e-101	323.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,1KJ1Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_1201876_1	706587.Desti_0745	3.44e-102	308.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42R1T@68525|delta/epsilon subdivisions,2WN88@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Cysteine-rich domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
k59_437938_2	991905.SL003B_0940	7.87e-66	212.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2TSBK@28211|Alphaproteobacteria,4BP8R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_1266740_1	1183438.GKIL_3929	2.25e-80	251.0	COG1228@1|root,COG1228@2|Bacteria,1G3PN@1117|Cyanobacteria	1117|Cyanobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_42811_1	1121013.P873_07000	1.89e-19	93.6	COG0790@1|root,COG4249@1|root,COG0790@2|Bacteria,COG4249@2|Bacteria,1MWPA@1224|Proteobacteria,1RRKA@1236|Gammaproteobacteria,1XC91@135614|Xanthomonadales	135614|Xanthomonadales	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,Sel1
k59_1671870_2	1088721.NSU_1526	1.11e-22	96.7	COG5486@1|root,COG5486@2|Bacteria,1NFSK@1224|Proteobacteria,2U4IW@28211|Alphaproteobacteria,2K99T@204457|Sphingomonadales	204457|Sphingomonadales	S	Predicted metal-binding integral membrane protein (DUF2182)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2182
k59_1505855_1	1121451.DESAM_22167	3.84e-50	179.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,42PE3@68525|delta/epsilon subdivisions,2WKM3@28221|Deltaproteobacteria,2M8WR@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_1733369_1	909663.KI867150_gene367	1.33e-39	150.0	COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,42U7P@68525|delta/epsilon subdivisions,2WQKY@28221|Deltaproteobacteria,2MQSP@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_281636_2	857087.Metme_2348	8.31e-08	50.4	COG3114@1|root,COG3114@2|Bacteria,1NGBM@1224|Proteobacteria,1SGGH@1236|Gammaproteobacteria,1XFW4@135618|Methylococcales	135618|Methylococcales	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	-	-	-	ko:K02196	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.107	-	-	CcmD
k59_281636_3	977880.RALTA_B0644	6.38e-48	159.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria,1K8MK@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
k59_789470_2	1095767.CAHD01000071_gene3102	9.83e-60	196.0	COG0438@1|root,COG0438@2|Bacteria,2ICHJ@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
k59_48878_1	857087.Metme_2348	8.96e-11	57.8	COG3114@1|root,COG3114@2|Bacteria,1NGBM@1224|Proteobacteria,1SGGH@1236|Gammaproteobacteria,1XFW4@135618|Methylococcales	135618|Methylococcales	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	-	-	-	ko:K02196	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.107	-	-	CcmD
k59_48878_2	395493.BegalDRAFT_2462	1.68e-41	141.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,1S5VA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015886,GO:0016020,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051181,GO:0051234,GO:0065003,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097159,GO:0098552,GO:0098567,GO:1901363,GO:1901564,GO:1901678	-	ko:K02197	-	-	-	-	ko00000	-	-	iSSON_1240.SSON_2255	CcmE
k59_1790295_1	1469245.JFBG01000086_gene1623	3.15e-101	305.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1WWH3@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_1441119_1	1385519.N801_10420	1.64e-93	302.0	COG0479@1|root,COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0479@2|Bacteria,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2I995@201174|Actinobacteria,4FITA@85021|Intrasporangiaceae	201174|Actinobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_677544_1	1219585.HMPREF1631_04215	3.01e-201	574.0	COG1274@1|root,COG1274@2|Bacteria,2GJH3@201174|Actinobacteria,4D49Q@85005|Actinomycetales	201174|Actinobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
k59_1097095_1	1121396.KB892935_gene3804	2.22e-59	202.0	COG1085@1|root,COG1085@2|Bacteria,1R6SM@1224|Proteobacteria,42QFF@68525|delta/epsilon subdivisions,2WKFN@28221|Deltaproteobacteria,2MIE7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	galactose-1-phosphate uridylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1868166_1	2340.JV46_02700	1.64e-134	394.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1J7KN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cysteine-rich domain	glpC	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944	1.1.5.3	ko:K00113,ko:K11473	ko00564,ko00630,ko01100,ko01110,ko01120,ko01130,map00564,map00630,map01100,map01110,map01120,map01130	-	R00475,R00848	RC00029,RC00042	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
k59_1339946_1	1304865.JAGF01000001_gene3625	4.17e-23	92.8	2EGIC@1|root,33AAH@2|Bacteria,2IKSC@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3099)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3099
k59_1339946_2	67281.JNZZ01000018_gene540	1.65e-16	72.8	2E3SR@1|root,32YQ8@2|Bacteria,2GQKG@201174|Actinobacteria,41B7K@629295|Streptomyces griseus group	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1676110_1	1335757.SPICUR_04595	2.66e-64	204.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,1WXR9@135613|Chromatiales	135613|Chromatiales	IQ	PFAM Short-chain dehydrogenase reductase SDR	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1556928_1	1454010.JEOE01000006_gene2167	1.56e-25	105.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,4F0ZC@85016|Cellulomonadaceae	201174|Actinobacteria	D	Ftsk_gamma	ftsK	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1868173_1	1249627.D779_1220	3.68e-28	110.0	COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,1RY2B@1236|Gammaproteobacteria,1WY1Q@135613|Chromatiales	135613|Chromatiales	S	PFAM transport-associated	-	-	-	-	-	-	-	-	-	-	-	-	BON
k59_987723_1	305900.GV64_00095	1.08e-35	132.0	28HKZ@1|root,2Z7VP@2|Bacteria,1R4QW@1224|Proteobacteria,1RZQX@1236|Gammaproteobacteria,1XPHX@135619|Oceanospirillales	135619|Oceanospirillales	S	Protein of unknown function (DUF3050)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3050
k59_106671_1	998674.ATTE01000001_gene4005	2.94e-88	270.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1SYDD@1236|Gammaproteobacteria,461UD@72273|Thiotrichales	72273|Thiotrichales	V	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
k59_928591_1	933262.AXAM01000053_gene2713	9.35e-104	319.0	COG4770@1|root,COG5016@1|root,COG4770@2|Bacteria,COG5016@2|Bacteria,1P6RE@1224|Proteobacteria,43BQE@68525|delta/epsilon subdivisions,2X71H@28221|Deltaproteobacteria,2MHKV@213118|Desulfobacterales	28221|Deltaproteobacteria	CI	Conserved carboxylase domain	-	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_1097110_1	396588.Tgr7_1857	9.44e-47	167.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WXY0@135613|Chromatiales	135613|Chromatiales	P	Sulfate transporter antisigma-factor antagonist STAS	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
k59_559407_1	713587.THITH_01775	1.65e-55	179.0	COG0209@1|root,COG0209@2|Bacteria,1P4EH@1224|Proteobacteria,1RP1A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	COG0209 Ribonucleotide reductase, alpha subunit	nrdJb	-	-	-	-	-	-	-	-	-	-	-	-
k59_618028_1	765914.ThisiDRAFT_1432	1.86e-78	253.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1WWAT@135613|Chromatiales	135613|Chromatiales	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_1271571_1	663610.JQKO01000006_gene2628	3.22e-29	113.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2TSMS@28211|Alphaproteobacteria,3NA6K@45404|Beijerinckiaceae	28211|Alphaproteobacteria	H	Ferrochelatase	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
k59_1271571_2	224911.27356034	2.49e-06	49.3	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2TRUY@28211|Alphaproteobacteria,3JSWN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	prohibitin homologues	qmcA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
k59_928612_2	998674.ATTE01000001_gene990	7.18e-52	168.0	COG1764@1|root,COG1764@2|Bacteria	2|Bacteria	O	response to oxidative stress	ymaD	-	-	-	-	-	-	-	-	-	-	-	OsmC
k59_1206681_1	243090.RB1231	6.85e-38	142.0	COG1249@1|root,COG1249@2|Bacteria,2IX5H@203682|Planctomycetes	203682|Planctomycetes	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3)	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_929842_1	1267005.KB911260_gene3441	7.63e-143	423.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2TQYG@28211|Alphaproteobacteria,3N696@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_50146_1	765911.Thivi_4352	2.83e-89	276.0	COG4398@1|root,COG4398@2|Bacteria,1MUX9@1224|Proteobacteria,1RPGR@1236|Gammaproteobacteria,1WWYY@135613|Chromatiales	135613|Chromatiales	S	FIST N domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
k59_282840_1	935839.JAGJ01000001_gene1302	4.7e-69	220.0	COG1609@1|root,COG1609@2|Bacteria,2GJBJ@201174|Actinobacteria,4F5JR@85017|Promicromonosporaceae	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
k59_1341213_1	1121468.AUBR01000030_gene1220	1.36e-51	175.0	COG0416@1|root,COG0416@2|Bacteria,1TPXS@1239|Firmicutes,247KW@186801|Clostridia,42F74@68295|Thermoanaerobacterales	186801|Clostridia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_1506792_1	1255043.TVNIR_0853	4.79e-144	419.0	COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria,1WXQI@135613|Chromatiales	135613|Chromatiales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8
k59_1097980_1	371731.Rsw2DRAFT_1853	7.39e-167	477.0	COG2516@1|root,COG2516@2|Bacteria,1MWZQ@1224|Proteobacteria,2U4HP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Radical SAM	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
k59_1097980_2	1417296.U879_08050	2.3e-85	261.0	COG1856@1|root,COG1856@2|Bacteria,1R6PW@1224|Proteobacteria,2U1YU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Radical SAM	-	-	-	ko:K09711	-	-	-	-	ko00000	-	-	-	Radical_SAM
k59_736971_1	314285.KT71_17271	1.81e-60	206.0	COG1404@1|root,COG1404@2|Bacteria,1PE2Y@1224|Proteobacteria,1SQ8B@1236|Gammaproteobacteria,1JBCF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_50193_1	1279009.ADICEAN_02544	7.04e-51	182.0	COG0308@1|root,COG0308@2|Bacteria,4NGTZ@976|Bacteroidetes,47MWS@768503|Cytophagia	976|Bacteroidetes	E	Peptidase family M1 domain	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
k59_1341262_1	614083.AWQR01000021_gene243	2.74e-09	63.2	COG3829@1|root,COG5001@1|root,COG3829@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VHPI@28216|Betaproteobacteria,4AAUI@80864|Comamonadaceae	28216|Betaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,EAL,GAF_2,GGDEF,PAS_4
k59_50216_1	521098.Aaci_1799	5.21e-51	177.0	COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,4HA7P@91061|Bacilli,2782W@186823|Alicyclobacillaceae	91061|Bacilli	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
k59_560102_2	472759.Nhal_3009	7.66e-47	155.0	COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,1S94K@1236|Gammaproteobacteria,1WYQ1@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III, chi subunit	-	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
k59_989080_1	1123392.AQWL01000006_gene636	5.99e-56	193.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2VHKJ@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Sulfate transporter antisigma-factor antagonist STAS	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
k59_1869534_1	243233.MCA1677	9.89e-138	402.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1XEEH@135618|Methylococcales	135618|Methylococcales	F	TIGRFAM glutamine synthetase, type I	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_618736_2	28444.JODQ01000006_gene562	0.000246	45.1	COG1877@1|root,COG1877@2|Bacteria,2IKKW@201174|Actinobacteria,4EKDD@85012|Streptosporangiales	201174|Actinobacteria	G	trehalose-phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_989085_1	1116472.MGMO_77c00230	4.27e-68	226.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1XE5G@135618|Methylococcales	135618|Methylococcales	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_989085_2	717774.Marme_2525	5.58e-130	378.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1XIQQ@135619|Oceanospirillales	135619|Oceanospirillales	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_50233_1	471853.Bcav_1154	9.68e-61	201.0	COG2114@1|root,COG2114@2|Bacteria,2GN02@201174|Actinobacteria	201174|Actinobacteria	T	PFAM Adenylyl cyclase class-3 4 guanylyl cyclase	cya	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Ad_Cy_reg,Guanylate_cyc
k59_737000_1	435908.IDSA_10635	8.44e-43	153.0	COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,1RN53@1236|Gammaproteobacteria,2QFIG@267893|Idiomarinaceae	1236|Gammaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	ywdH	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_790082_1	768671.ThimaDRAFT_2616	1.65e-05	50.8	2CI39@1|root,32VJ3@2|Bacteria,1N3UR@1224|Proteobacteria,1SBDS@1236|Gammaproteobacteria,1WYYR@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_929943_1	1235794.C811_00023	6.01e-07	56.6	COG0243@1|root,COG0243@2|Bacteria,2GJCK@201174|Actinobacteria,4CUTH@84998|Coriobacteriia	84998|Coriobacteriia	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1557661_1	706587.Desti_4580	3.64e-112	332.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,42MW8@68525|delta/epsilon subdivisions,2WKI6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	phaC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_1441888_1	1131813.AQVT01000001_gene2981	3.43e-65	217.0	COG2185@1|root,COG2185@2|Bacteria,1QU3N@1224|Proteobacteria,2TVY1@28211|Alphaproteobacteria,1JS9Z@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
k59_50241_1	1454010.JEOE01000001_gene699	7.34e-20	81.3	COG1758@1|root,COG1758@2|Bacteria,2IQHU@201174|Actinobacteria,4F1EY@85016|Cellulomonadaceae	201174|Actinobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
k59_50241_2	446466.Cfla_1852	7.29e-73	231.0	COG0452@1|root,COG0452@2|Bacteria,2GJGJ@201174|Actinobacteria,4F0SE@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k59_1734138_1	1033802.SSPSH_000916	4.14e-08	55.8	COG0583@1|root,COG0583@2|Bacteria,1PX1B@1224|Proteobacteria,1SYEI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_325777_1	1049564.TevJSym_am00100	2.21e-37	139.0	COG2433@1|root,COG2433@2|Bacteria,1N0ZS@1224|Proteobacteria,1S7FF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124
k59_501526_1	1191523.MROS_0316	2.7e-80	252.0	COG0472@1|root,COG0472@2|Bacteria	2|Bacteria	M	phospho-N-acetylmuramoyl-pentapeptide-transferase activity	mraY	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105	Glycos_transf_4,MraY_sig1
k59_1341317_1	335543.Sfum_0119	8.32e-40	149.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
k59_1098044_1	396588.Tgr7_1272	1.18e-28	104.0	COG0298@1|root,COG0298@2|Bacteria,1QKV6@1224|Proteobacteria,1SE6V@1236|Gammaproteobacteria,1WZDC@135613|Chromatiales	135613|Chromatiales	O	PFAM hydrogenase expression formation protein (HUPF HYPC)	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
k59_1098044_2	572477.Alvin_2766	3.36e-35	124.0	COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,1S5WG@1236|Gammaproteobacteria,1WYQN@135613|Chromatiales	135613|Chromatiales	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
k59_989111_2	283942.IL0427	9.08e-41	140.0	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,2QFXB@267893|Idiomarinaceae	1236|Gammaproteobacteria	K	Belongs to the MraZ family	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
k59_1272517_1	1208323.B30_20061	6.72e-23	103.0	COG4191@1|root,COG4191@2|Bacteria,1MVK7@1224|Proteobacteria,2TR44@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	signal transduction histidine kinase	regM	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_1791014_2	314278.NB231_06296	5.21e-30	116.0	COG1763@1|root,COG1763@2|Bacteria,1QYTH@1224|Proteobacteria,1T3U1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Mo-molybdopterin cofactor biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_618763_1	595494.Tola_2244	1.12e-35	132.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1Y3M6@135624|Aeromonadales	135624|Aeromonadales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
k59_737023_1	395493.BegalDRAFT_0232	5.08e-54	182.0	COG4651@1|root,COG4651@2|Bacteria,1QUQS@1224|Proteobacteria,1T21E@1236|Gammaproteobacteria,461MK@72273|Thiotrichales	72273|Thiotrichales	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_50275_1	296591.Bpro_1379	1.44e-25	107.0	COG2771@1|root,COG2771@2|Bacteria,1MWC0@1224|Proteobacteria,2VX4W@28216|Betaproteobacteria,4AFSX@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE
k59_1206759_1	1232437.KL661990_gene407	8.52e-22	99.0	2A7N3@1|root,30WK3@2|Bacteria,1NERD@1224|Proteobacteria,42P7M@68525|delta/epsilon subdivisions,2WJTH@28221|Deltaproteobacteria,2MIHK@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1615930_1	519989.ECTPHS_07326	1.37e-123	378.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWI3@135613|Chromatiales	135613|Chromatiales	L	PFAM UvrD REP helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1615930_2	391615.ABSJ01000014_gene1624	3.93e-71	228.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,1J5GM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_208585_1	1304865.JAGF01000001_gene3738	1.07e-90	275.0	COG0039@1|root,COG0039@2|Bacteria,2GN5S@201174|Actinobacteria,4F1NU@85016|Cellulomonadaceae	201174|Actinobacteria	C	Belongs to the LDH MDH superfamily. LDH family	ldh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
k59_1734158_1	335543.Sfum_1174	1.26e-40	134.0	COG1908@1|root,COG1908@2|Bacteria,1NFTQ@1224|Proteobacteria,42VFD@68525|delta/epsilon subdivisions,2WS6S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
k59_1615935_1	933262.AXAM01000016_gene189	5.33e-59	189.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria,2MIHA@213118|Desulfobacterales	28221|Deltaproteobacteria	N	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
k59_1615935_2	933262.AXAM01000016_gene190	7.88e-12	65.5	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NF6@68525|delta/epsilon subdivisions,2WKVH@28221|Deltaproteobacteria,2MI4N@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_150093_1	1336233.JAEH01000002_gene1372	1.22e-64	215.0	COG1922@1|root,COG2148@1|root,COG1922@2|Bacteria,COG2148@2|Bacteria,1N1HD@1224|Proteobacteria,1RP6P@1236|Gammaproteobacteria,2QAQA@267890|Shewanellaceae	1236|Gammaproteobacteria	M	TIGRFAM glycosyl transferase, WecB TagA CpsF family	gumM	-	2.4.1.187	ko:K05946,ko:K13660	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Bac_transf,Glyco_tran_WecB
k59_678398_1	1049564.TevJSym_bl00170	3.13e-77	239.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,1J4V1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	HflC and HflK could regulate a protease	hflC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_678398_2	1005999.GLGR_2707	2.15e-08	57.4	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
k59_1615940_2	999611.KI421504_gene2791	1.78e-77	237.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,2TS8T@28211|Alphaproteobacteria,280V4@191028|Leisingera	28211|Alphaproteobacteria	O	ATPases associated with a variety of cellular activities	sufC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
k59_1506892_1	1499967.BAYZ01000180_gene4412	1.68e-70	231.0	COG0334@1|root,COG0517@1|root,COG0334@2|Bacteria,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	aer	-	1.4.1.2	ko:K03406,ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,ko02020,ko02030,map00220,map00250,map00430,map00910,map01100,map02020,map02030	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000,ko02035	-	-	-	CBS,HATPase_c,HisKA,MCPsignal,Response_reg,SpoIIE
k59_282988_2	1121127.JAFA01000002_gene1534	1.77e-23	99.8	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2VIXM@28216|Betaproteobacteria,1K1IR@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_1797938_3	585425.KR52_06415	2.5e-20	85.1	COG3411@1|root,COG3411@2|Bacteria,1G5V6@1117|Cyanobacteria,1H0SH@1129|Synechococcus	1117|Cyanobacteria	C	ferredoxin like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1281168_1	314285.KT71_09582	3.87e-80	257.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1J572@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Oligopeptidase A	prlC	GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006465,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0034645,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051604,GO:0070011,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901576	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_1623650_1	519989.ECTPHS_08423	1.93e-112	339.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1WWDA@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA	rlmD	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_1281172_2	1502851.FG93_03340	5.8e-29	105.0	COG3514@1|root,COG3514@2|Bacteria,1MZPR@1224|Proteobacteria,2UCYI@28211|Alphaproteobacteria,3K08A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	BrnA antitoxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	BrnA_antitoxin
k59_1565489_1	1249627.D779_0603	3.6e-17	81.3	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RNES@1236|Gammaproteobacteria,1X2HE@135613|Chromatiales	135613|Chromatiales	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1565489_2	765912.Thimo_2069	8.84e-42	142.0	COG1376@1|root,COG1376@2|Bacteria,1RHBG@1224|Proteobacteria,1S6DY@1236|Gammaproteobacteria,1X25T@135613|Chromatiales	135613|Chromatiales	S	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_1449653_1	933262.AXAM01000004_gene2383	1.76e-81	252.0	COG0613@1|root,COG0613@2|Bacteria,1NFVB@1224|Proteobacteria,43BBY@68525|delta/epsilon subdivisions,2X6R1@28221|Deltaproteobacteria,2MPIB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2889)	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	APH,DUF2889,PHP_C
k59_1150802_1	589865.DaAHT2_0950	1.23e-65	219.0	COG1038@1|root,COG1038@2|Bacteria,1R7P1@1224|Proteobacteria,42PQ3@68525|delta/epsilon subdivisions,2WJK5@28221|Deltaproteobacteria,2MJRR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Conserved carboxylase domain	-	-	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_1033754_1	935565.JAEM01000051_gene4322	8.99e-111	337.0	COG3962@1|root,COG3962@2|Bacteria,1MW0P@1224|Proteobacteria,2TR12@28211|Alphaproteobacteria,2PUHN@265|Paracoccus	28211|Alphaproteobacteria	E	Thiamine pyrophosphate enzyme, central domain	-	-	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_334147_1	338963.Pcar_0328	6.78e-77	246.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,43S90@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	DbpA RNA binding domain	deaD	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
k59_861621_2	626887.J057_19260	1.99e-08	56.2	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,1RS0S@1236|Gammaproteobacteria,4679X@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine	xapA	GO:0003674,GO:0003824,GO:0004731,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006148,GO:0006149,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0008617,GO:0009056,GO:0009116,GO:0009119,GO:0009120,GO:0009164,GO:0009987,GO:0015949,GO:0016043,GO:0016740,GO:0016757,GO:0016763,GO:0016787,GO:0016798,GO:0016799,GO:0019439,GO:0022607,GO:0034214,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0042454,GO:0042802,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046094,GO:0046102,GO:0046115,GO:0046121,GO:0046122,GO:0046124,GO:0046128,GO:0046130,GO:0046483,GO:0046700,GO:0047724,GO:0047975,GO:0051259,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0072521,GO:0072523,GO:1901068,GO:1901069,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658,GO:1903227,GO:1903228	2.4.2.1,2.4.2.28,2.4.2.44	ko:K00772,ko:K03783,ko:K03815,ko:K19696	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R09668,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO1171,iUMN146_1321.UM146_04590,iUTI89_1310.UTI89_C2739	PNP_UDP_1
k59_686346_1	991905.SL003B_0494	2.63e-144	412.0	COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria,4BRIA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3293 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_568131_2	765913.ThidrDRAFT_0428	1.66e-28	110.0	COG1192@1|root,COG1192@2|Bacteria,1MWRE@1224|Proteobacteria,1RMZN@1236|Gammaproteobacteria,1WWIN@135613|Chromatiales	135613|Chromatiales	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
k59_1515392_1	471853.Bcav_2453	1.52e-166	514.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria	201174|Actinobacteria	L	dead DEAH box helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
k59_1033766_2	1045855.DSC_05160	1.02e-73	238.0	COG3039@1|root,COG3039@2|Bacteria,1R64B@1224|Proteobacteria	1224|Proteobacteria	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_568141_1	1357423.S5MV15_9CAUD	1.09e-23	106.0	4QAJ5@10239|Viruses,4QUS9@35237|dsDNA viruses  no RNA stage,4QPY5@28883|Caudovirales,4QHUT@10662|Myoviridae	10662|Myoviridae	S	Major capsid protein Gp23	-	GO:0005575,GO:0019012,GO:0019028,GO:0044423	-	-	-	-	-	-	-	-	-	-	-
k59_293522_1	710696.Intca_2912	1.03e-97	307.0	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria,4FEZA@85021|Intrasporangiaceae	201174|Actinobacteria	G	Alpha-amylase domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_1106872_1	596151.DesfrDRAFT_1898	1.36e-45	150.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,42VCF@68525|delta/epsilon subdivisions,2WRI6@28221|Deltaproteobacteria,2ME7G@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
k59_1106872_2	1121396.KB893012_gene4038	1.19e-27	103.0	COG1908@1|root,COG1908@2|Bacteria,1NUHP@1224|Proteobacteria,42ZKK@68525|delta/epsilon subdivisions,2WUW1@28221|Deltaproteobacteria,2MNCX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
k59_158105_1	1385520.N802_08610	1.56e-79	247.0	COG0520@1|root,COG0520@2|Bacteria,2GJA4@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase class v	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_568147_1	498211.CJA_2486	7.28e-33	133.0	COG2755@1|root,COG2755@2|Bacteria,1R43M@1224|Proteobacteria,1RRTK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2,TPR_19
k59_1515410_1	713586.KB900536_gene1150	1.63e-61	202.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1WWJA@135613|Chromatiales	135613|Chromatiales	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_1623697_1	1500306.JQLA01000002_gene1773	3.88e-36	128.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2U9GC@28211|Alphaproteobacteria,4BCT5@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
k59_1449706_1	713586.KB900536_gene2578	1.41e-86	265.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
k59_1281240_1	269796.Rru_A3564	1.66e-06	50.4	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,2TRW1@28211|Alphaproteobacteria,2JT4Q@204441|Rhodospirillales	204441|Rhodospirillales	E	D,D-heptose 1,7-bisphosphate phosphatase	gmhB	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_6,Hydrolase_like,NTP_transferase
k59_1281240_2	1158345.JNLL01000001_gene846	1.48e-25	107.0	COG0317@1|root,COG0317@2|Bacteria,2G3JQ@200783|Aquificae	200783|Aquificae	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_568161_1	1217714.F975_00574	1.83e-06	50.4	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,3NJWF@468|Moraxellaceae	1236|Gammaproteobacteria	H	Belongs to the ribF family	ribF	GO:0003674,GO:0003824,GO:0003919,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008531,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0044237,GO:0070566	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iETEC_1333.ETEC_0025,iJN746.PP_0602	FAD_syn,Flavokinase
k59_568161_2	314278.NB231_04002	1.65e-11	66.6	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1WWAE@135613|Chromatiales	135613|Chromatiales	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_334203_1	1454010.JEOE01000015_gene1130	7.79e-13	73.6	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria	201174|Actinobacteria	P	PFAM PKD domain containing protein	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
k59_1798003_1	743836.AYNA01000044_gene1175	5.1e-55	185.0	COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2TQQ0@28211|Alphaproteobacteria,36XCI@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Glycosyltransferase Family 4	mgtA	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
k59_686396_2	1278078.G419_24014	5.46e-57	194.0	COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4FX7J@85025|Nocardiaceae	201174|Actinobacteria	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.3.15	ko:K00104,ko:K08167	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	M00713,M00714	R00475	RC00042	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	2.A.1.3	-	-	FAD-oxidase_C,FAD_binding_4
k59_626992_1	2340.JV46_08030	1.33e-130	377.0	COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,1JA5H@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	LysR substrate binding domain	oxyR	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
k59_1623723_1	396588.Tgr7_0336	1.3e-159	455.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1WW2B@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
k59_1449738_2	1144275.COCOR_03271	9.84e-24	95.1	COG3628@1|root,COG3628@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K06903	-	-	-	-	ko00000	-	-	-	GPW_gp25
k59_1742586_1	653733.Selin_1261	5.56e-76	244.0	COG0513@1|root,COG0513@2|Bacteria	2|Bacteria	L	helicase activity	rhlB	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0019904,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0090304,GO:0097718,GO:0140098,GO:1901360,GO:1901361,GO:1901575	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_1515457_1	391615.ABSJ01000049_gene1542	1.39e-142	429.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1J57N@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1033835_1	991905.SL003B_0174	5.85e-60	197.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2TQMF@28211|Alphaproteobacteria,4BPZE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	MA20_25320	-	1.1.1.1,1.6.5.5	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1623733_1	367299.JOEE01000004_gene1085	5.1e-55	179.0	COG2335@1|root,COG2335@2|Bacteria	2|Bacteria	M	COG2335, Secreted and surface protein containing fasciclin-like repeats	-	-	-	ko:K19519	-	-	-	-	ko00000,ko04516	-	-	-	Fasciclin,Lipoprotein_15
k59_1150876_1	1049564.TevJSym_be00180	1.28e-36	131.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,1J6Q8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
k59_1150876_2	497321.C664_03927	1.84e-20	90.1	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,2KUUQ@206389|Rhodocyclales	206389|Rhodocyclales	U	Involved in the tonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_796459_1	926549.KI421517_gene748	2.97e-59	204.0	COG0531@1|root,COG0531@2|Bacteria,4NHS2@976|Bacteroidetes,47MER@768503|Cytophagia	976|Bacteroidetes	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_1742610_1	1082933.MEA186_15492	5.89e-08	53.9	COG0580@1|root,COG0580@2|Bacteria,1PPTN@1224|Proteobacteria,2TW8M@28211|Alphaproteobacteria,43P97@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Belongs to the MIP aquaporin (TC 1.A.8) family	aqpZ	-	-	-	-	-	-	-	-	-	-	-	MIP
k59_509744_1	768671.ThimaDRAFT_4706	8.05e-129	378.0	COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,1RQ6N@1236|Gammaproteobacteria,1WX18@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_861737_1	631362.Thi970DRAFT_04215	2.93e-70	216.0	COG3751@1|root,COG3751@2|Bacteria,1RBXB@1224|Proteobacteria,1RR8W@1236|Gammaproteobacteria,1WWUG@135613|Chromatiales	135613|Chromatiales	O	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_3
k59_861737_2	1356852.N008_10660	4.2e-36	128.0	COG0454@1|root,COG0456@2|Bacteria,4NU41@976|Bacteroidetes,47T5Q@768503|Cytophagia	976|Bacteroidetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
k59_1565590_1	1249627.D779_3254	4.59e-84	258.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria,1WWVX@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_334266_1	391615.ABSJ01000050_gene1234	6.03e-46	159.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RN3S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_1449775_1	1122603.ATVI01000005_gene3497	1.25e-57	205.0	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1T49A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1214540_1	1122599.AUGR01000019_gene3068	8.26e-195	548.0	COG3500@1|root,COG3500@2|Bacteria,1Q2U5@1224|Proteobacteria,1RQ3S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Late control gene D protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_686441_1	13037.EHJ74677	0.000423	47.8	2D5I3@1|root,2SYNA@2759|Eukaryota	2759|Eukaryota	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_509763_1	1049564.TevJSym_bb00370	4.76e-46	159.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1J5V1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	signal transduction protein with a C-terminal ATPase domain	algZ	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
k59_796482_1	765910.MARPU_02475	1.55e-158	461.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales	135613|Chromatiales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_861757_1	2340.JV46_28450	2.55e-62	201.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1J4VV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	recombinase XerD	xerD	GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_861757_2	450380.JPSY01000001_gene801	1.52e-12	64.7	COG0350@1|root,COG0350@2|Bacteria,2IPIE@201174|Actinobacteria,4FTFU@85023|Microbacteriaceae	201174|Actinobacteria	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
k59_1281322_1	1267005.KB911264_gene3197	4.09e-102	313.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria,3N620@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_1449791_1	367299.JOEE01000007_gene204	9.44e-52	167.0	COG5516@1|root,COG5516@2|Bacteria,2GNZF@201174|Actinobacteria,4FGX9@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative stress-induced transcription regulator	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
k59_1449791_2	367299.JOEE01000007_gene205	5.5e-33	122.0	COG0462@1|root,COG0462@2|Bacteria,2GJ9S@201174|Actinobacteria,4FE7Y@85021|Intrasporangiaceae	201174|Actinobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_1515513_1	1156937.MFUM_720018	5.46e-27	115.0	COG0112@1|root,COG0112@2|Bacteria,46S5I@74201|Verrucomicrobia,37G4S@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	LMWPc,LacAB_rpiB,SHMT
k59_1214555_1	1117647.M5M_14150	4.65e-37	135.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,1S612@1236|Gammaproteobacteria,1J6KP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	ygfA	GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c31940,iECOK1_1307.ECOK1_3298,iECSF_1327.ECSF_2705,iUTI89_1310.UTI89_C3298	5-FTHF_cyc-lig
k59_1744284_1	670307.HYPDE_35228	5.22e-69	222.0	COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria,3N676@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	response regulator	pleD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,Response_reg
k59_1283194_1	246200.SPOA0220	4.12e-93	288.0	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,2U2TJ@28211|Alphaproteobacteria,4NBKA@97050|Ruegeria	28211|Alphaproteobacteria	C	Cytochrome D1 heme domain	nirS	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_687914_1	2340.JV46_05270	7.55e-42	146.0	COG2863@1|root,COG2863@2|Bacteria,1R8K9@1224|Proteobacteria,1S1Q4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	PFAM Cytochrome C	fccA	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K17230	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_1567125_1	439235.Dalk_3669	1.26e-127	373.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42MSJ@68525|delta/epsilon subdivisions,2WKHJ@28221|Deltaproteobacteria,2MITB@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_1216264_1	76869.PputGB1_3538	1.58e-32	122.0	COG2863@1|root,COG2863@2|Bacteria,1RGTS@1224|Proteobacteria,1SBUU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_1517429_1	1249627.D779_3210	5.84e-85	272.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WW1G@135613|Chromatiales	135613|Chromatiales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1391371_1	1121952.ATXT01000015_gene244	2.99e-84	260.0	COG1216@1|root,COG1216@2|Bacteria,2I6P4@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyltransferase WbsX	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_WbsX
k59_1391375_1	526225.Gobs_1995	4.92e-15	80.1	COG2114@1|root,COG3629@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Guanylate_cyc,NB-ARC,Trans_reg_C
k59_863543_1	414684.RC1_3663	1.4e-31	125.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,2TST5@28211|Alphaproteobacteria,2JPBX@204441|Rhodospirillales	204441|Rhodospirillales	P	COG0530 Ca2 Na antiporter	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_1625391_1	765912.Thimo_1859	3.46e-108	324.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,1MY9R@1224|Proteobacteria,1S28T@1236|Gammaproteobacteria,1WY61@135613|Chromatiales	135613|Chromatiales	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50,Peptidase_M50B
k59_1799392_1	96561.Dole_0670	8.35e-94	296.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria,2MI7X@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_1451589_1	1278971.AOGF01000008_gene141	1.24e-67	217.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,1Y84K@135625|Pasteurellales	135625|Pasteurellales	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	GO:0002097,GO:0002098,GO:0002143,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_1451589_2	1101195.Meth11DRAFT_0485	1.97e-37	133.0	2CDCV@1|root,308Y1@2|Bacteria,1N74F@1224|Proteobacteria,2VSMP@28216|Betaproteobacteria,2KMRH@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_746668_1	91464.S7335_701	2.15e-25	103.0	COG0758@1|root,COG0758@2|Bacteria,1GACU@1117|Cyanobacteria	1117|Cyanobacteria	LU	Putative molybdenum carrier	-	-	-	-	-	-	-	-	-	-	-	-	MoCo_carrier
k59_452652_1	1140.Synpcc7942_1207	1.11e-22	90.1	COG4115@1|root,COG4115@2|Bacteria,1G87X@1117|Cyanobacteria,1H3VD@1129|Synechococcus	1117|Cyanobacteria	S	YoeB-like toxin of bacterial type II toxin-antitoxin system	-	-	-	ko:K19158	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	YoeB_toxin
k59_452652_2	767029.HMPREF9154_2649	2.92e-33	116.0	COG2161@1|root,COG2161@2|Bacteria,2IQ6H@201174|Actinobacteria	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	relJ	GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K19159	-	-	-	-	ko00000,ko02048	-	-	-	PhdYeFM_antitox
k59_217914_1	388413.ALPR1_16618	5.14e-32	120.0	COG3153@1|root,COG3153@2|Bacteria,4NP1G@976|Bacteroidetes,47QSB@768503|Cytophagia	976|Bacteroidetes	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_9,Zn_ribbon_2
k59_217914_2	1298593.TOL_3046	5.82e-06	48.9	2C2C7@1|root,2Z85G@2|Bacteria,1PD07@1224|Proteobacteria,1RP6G@1236|Gammaproteobacteria,1XIKZ@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1567168_1	748247.AZKH_p0420	1.56e-85	257.0	28NKC@1|root,2ZBM7@2|Bacteria,1MWMY@1224|Proteobacteria,2VQ6Y@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_757439_2	70601.3258089	3.46e-32	119.0	COG1014@1|root,arCOG01602@2157|Archaea,2XUK0@28890|Euryarchaeota,243CA@183968|Thermococci	183968|Thermococci	C	ferredoxin oxidoreductase, subunit gamma	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
k59_757446_1	406818.XBJ1_0850	2.37e-34	128.0	COG2082@1|root,COG2082@2|Bacteria,1MX1E@1224|Proteobacteria,1RYUX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Precorrin-8X methylmutase	cobH	-	5.4.99.60,5.4.99.61	ko:K06042	ko00860,ko01100,map00860,map01100	-	R05177,R05814	RC01292,RC01980	ko00000,ko00001,ko01000	-	-	-	CbiC
k59_1048211_2	998674.ATTE01000001_gene2586	1.07e-16	75.9	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,460KM@72273|Thiotrichales	72273|Thiotrichales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_697681_1	180281.CPCC7001_2735	1.32e-54	187.0	COG5361@1|root,COG5361@2|Bacteria,1G49Q@1117|Cyanobacteria,22TNQ@167375|Cyanobium	1117|Cyanobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1753458_1	744980.TRICHSKD4_5120	2.54e-86	275.0	COG1686@1|root,COG3266@1|root,COG1686@2|Bacteria,COG3266@2|Bacteria,1MUU7@1224|Proteobacteria,2TRCV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the peptidase S11 family	dacA1	-	3.4.16.4	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11,SPOR
k59_1402107_1	335543.Sfum_3485	3.33e-87	271.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,42NGK@68525|delta/epsilon subdivisions,2WM29@28221|Deltaproteobacteria,2MQBW@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2768	NTP_transferase
k59_805771_1	765913.ThidrDRAFT_0318	8.48e-160	474.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WW6D@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_518973_1	1121946.AUAX01000009_gene4357	6.02e-41	147.0	COG1215@1|root,COG1215@2|Bacteria,2I2H4@201174|Actinobacteria,4DMEC@85008|Micromonosporales	201174|Actinobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_518973_2	1179773.BN6_25310	1.94e-27	108.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4DYBI@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	degT	-	2.6.1.106	ko:K13310	ko00523,ko01130,map00523,map01130	M00797	R06426	RC00006,RC01514	ko00000,ko00001,ko00002,ko01000	-	-	-	DegT_DnrJ_EryC1
k59_461496_1	768671.ThimaDRAFT_2176	5.74e-198	564.0	COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,1RNFJ@1236|Gammaproteobacteria,1WWXB@135613|Chromatiales	135613|Chromatiales	T	PFAM PrkA AAA	-	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
k59_1048260_1	580332.Slit_0535	2.56e-67	223.0	COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,2VQGZ@28216|Betaproteobacteria	28216|Betaproteobacteria	PT	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,cNMP_binding
k59_757492_1	1499680.CCFE01000013_gene950	2.3e-12	72.0	COG0664@1|root,COG0664@2|Bacteria,1V3XW@1239|Firmicutes,4HZTJ@91061|Bacilli,1ZEZA@1386|Bacillus	91061|Bacilli	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
k59_1697571_1	765911.Thivi_3993	6.57e-87	273.0	COG2863@1|root,COG3258@1|root,COG2863@2|Bacteria,COG3258@2|Bacteria,1NIQK@1224|Proteobacteria,1RZH1@1236|Gammaproteobacteria,1WXQK@135613|Chromatiales	135613|Chromatiales	C	PFAM Cytochrome C	-	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0016667,GO:0016669,GO:0022900,GO:0042597,GO:0044237,GO:0044464,GO:0050338,GO:0055114	1.8.2.2	ko:K19713	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_578755_1	1121441.AUCX01000005_gene1397	1.78e-31	123.0	COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,42NTH@68525|delta/epsilon subdivisions,2WJ8N@28221|Deltaproteobacteria,2M9JT@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
k59_1753486_1	1120966.AUBU01000001_gene773	6.62e-18	83.2	COG3832@1|root,COG3832@2|Bacteria,4NPKI@976|Bacteroidetes,47UX1@768503|Cytophagia	976|Bacteroidetes	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
k59_1808121_2	1076550.LH22_07175	0.000139	45.8	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,3VZDU@53335|Pantoea	1236|Gammaproteobacteria	M	lytic murein transglycosylase B	mltB	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031402,GO:0031420,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0044462,GO:0044464,GO:0046872,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	iECABU_c1320.ECABU_c29710,iNRG857_1313.NRG857_13215	SLT_2
k59_228461_1	935839.JAGJ01000008_gene1703	1.05e-42	157.0	COG4987@1|root,COG4987@2|Bacteria,2H79B@201174|Actinobacteria,4F41C@85017|Promicromonosporaceae	201174|Actinobacteria	V	TIGRFAM ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC	cydC	-	-	ko:K06148,ko:K16012	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.129	-	-	ABC_membrane,ABC_tran
k59_757515_2	187272.Mlg_2865	4.78e-82	262.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1WW41@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_1461969_1	882.DVU_0126	1.18e-36	141.0	COG0842@1|root,COG1131@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WK9W@28221|Deltaproteobacteria,2MA8B@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	pfam abc	-	-	-	ko:K01990,ko:K01992,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC2_membrane_3,ABC_tran
k59_875555_1	335543.Sfum_0936	6.36e-105	311.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2WIQD@28221|Deltaproteobacteria,2MR82@213462|Syntrophobacterales	28221|Deltaproteobacteria	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_1697612_1	1121405.dsmv_1721	1.04e-93	288.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria,2MIIU@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_461538_1	880073.Calab_2016	9.62e-06	48.1	COG2111@1|root,COG2111@2|Bacteria,2NPU9@2323|unclassified Bacteria	2|Bacteria	P	Domain related to MnhB subunit of Na+/H+ antiporter	-	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MnhB
k59_461538_2	795955.AFRW01000099_gene2102	3.49e-08	58.2	COG1006@1|root,COG1006@2|Bacteria,2ISBC@201174|Actinobacteria,1W9F1@1268|Micrococcaceae	201174|Actinobacteria	P	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	mrpC	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
k59_461538_3	456320.Mvol_1248	2.21e-08	62.4	COG0651@1|root,arCOG01537@2157|Archaea,2XU88@28890|Euryarchaeota,23QQ6@183939|Methanococci	183939|Methanococci	C	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K14115	-	-	-	-	ko00000	-	-	-	Proton_antipo_M
k59_345895_1	246200.SPO3036	4.78e-173	500.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria,4ND2Q@97050|Ruegeria	28211|Alphaproteobacteria	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_805827_1	765910.MARPU_11355	1.11e-83	260.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1WX7X@135613|Chromatiales	135613|Chromatiales	J	SAM-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
k59_1697619_2	367299.JOEE01000008_gene609	1.94e-76	237.0	COG2378@1|root,COG2378@2|Bacteria,2GMAU@201174|Actinobacteria,4FEBU@85021|Intrasporangiaceae	201174|Actinobacteria	K	Proteasome accessory factor C	pafC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
k59_463031_1	1227487.C474_11745	5.09e-53	170.0	COG0251@1|root,arCOG01630@2157|Archaea,2XY4I@28890|Euryarchaeota,23X7B@183963|Halobacteria	183963|Halobacteria	J	translation initiation inhibitor, yjgF family	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_463031_2	1123504.JQKD01000012_gene1362	3.55e-38	147.0	COG3751@1|root,COG3751@2|Bacteria,1NG7K@1224|Proteobacteria,2VK5Y@28216|Betaproteobacteria,4AAXY@80864|Comamonadaceae	28216|Betaproteobacteria	O	SMART Prolyl 4-hydroxylase, alpha subunit	-	-	1.14.11.2	ko:K00472	ko00330,ko01100,map00330,map01100	-	R01252	RC00478	ko00000,ko00001,ko01000	-	-	-	2OG-FeII_Oxy_3
k59_520141_1	768671.ThimaDRAFT_2243	2.3e-70	228.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1WWAE@135613|Chromatiales	135613|Chromatiales	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_807198_1	1122197.ATWI01000009_gene2105	1.88e-13	66.6	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,1S3VN@1236|Gammaproteobacteria,466US@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016866,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034023,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	iETEC_1333.ETEC_0575,iJN746.PP_5336,iPC815.YPO3076,iUTI89_1310.UTI89_C0551	AIRC
k59_807198_2	83406.HDN1F_06250	6.54e-17	81.3	COG3028@1|root,COG3028@2|Bacteria,1MZ4R@1224|Proteobacteria,1S9JJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the UPF0307 family	yjgA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K09889	-	-	-	-	ko00000,ko03009	-	-	-	DUF615
k59_230188_1	388051.AUFE01000006_gene1311	4.63e-112	346.0	COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,2VJMQ@28216|Betaproteobacteria,1K58M@119060|Burkholderiaceae	28216|Betaproteobacteria	HJM	Belongs to the MurCDEF family	cphA1	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M,RimK
k59_699346_1	306281.AJLK01000196_gene5745	6.88e-23	101.0	COG0612@1|root,COG0612@2|Bacteria,1G303@1117|Cyanobacteria,1JH4Z@1189|Stigonemataceae	1117|Cyanobacteria	S	Peptidase M16 inactive domain	ymxG	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_807220_1	1183377.Py04_1462	9.43e-34	128.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTX2@28890|Euryarchaeota,242XP@183968|Thermococci	183968|Thermococci	O	AIR synthase related protein, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
k59_463080_1	931626.Awo_c21160	6.41e-24	92.8	COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,24QKN@186801|Clostridia,25X88@186806|Eubacteriaceae	186801|Clostridia	S	Belongs to the UPF0109 family	ylqC	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
k59_639222_1	765911.Thivi_3223	5.94e-79	259.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1WXI8@135613|Chromatiales	135613|Chromatiales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_1580843_1	399795.CtesDRAFT_PD1759	0.000326	44.3	COG2010@1|root,COG2010@2|Bacteria,1P1GY@1224|Proteobacteria,2VP4W@28216|Betaproteobacteria,4ABQU@80864|Comamonadaceae	28216|Betaproteobacteria	C	Cytochrome c	soxX	-	-	ko:K17223	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
k59_1580843_2	762376.AXYL_05426	8.62e-66	208.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,2VJ8Q@28216|Betaproteobacteria,3T62I@506|Alcaligenaceae	28216|Betaproteobacteria	C	Thiosulfate-oxidizing multienzyme system protein SoxA	-	-	-	ko:K17222	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	-
k59_1163088_1	290398.Csal_0444	4.94e-23	90.9	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,1S3Q2@1236|Gammaproteobacteria,1XJQU@135619|Oceanospirillales	135619|Oceanospirillales	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
k59_1163088_2	1538295.JY96_07565	7.47e-55	174.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,2VR2K@28216|Betaproteobacteria,1KKTC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_1163088_3	396588.Tgr7_2304	2.3e-193	548.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1WWJA@135613|Chromatiales	135613|Chromatiales	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_1050810_1	1121121.KB894284_gene574	5.03e-24	99.4	COG2197@1|root,COG2197@2|Bacteria,1TRXG@1239|Firmicutes,4HA3V@91061|Bacilli,26R24@186822|Paenibacillaceae	91061|Bacilli	KT	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	degU	-	-	ko:K02479,ko:K07692	ko02020,ko02024,map02020,map02024	M00478	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_347556_1	526222.Desal_1934	3.57e-09	58.2	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,42V77@68525|delta/epsilon subdivisions,2WRQF@28221|Deltaproteobacteria,2MCBQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
k59_347556_2	1469245.JFBG01000088_gene1667	2.32e-120	356.0	COG0420@1|root,COG0420@2|Bacteria,1MY4X@1224|Proteobacteria,1RSFB@1236|Gammaproteobacteria,1X13V@135613|Chromatiales	135613|Chromatiales	L	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_172380_1	176299.Atu3818	1.4e-44	162.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria,4B8TA@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and or methyl galactoside import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
k59_1638085_1	929558.SMGD1_1616	1.04e-64	215.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2YN4S@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	Na Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans
k59_463118_1	713586.KB900536_gene1905	9.62e-51	166.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,1S60E@1236|Gammaproteobacteria,1WY9G@135613|Chromatiales	135613|Chromatiales	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
k59_580396_1	1415780.JPOG01000001_gene1326	3.93e-13	69.3	COG4795@1|root,COG4795@2|Bacteria,1RJAE@1224|Proteobacteria,1S5ZZ@1236|Gammaproteobacteria,1X777@135614|Xanthomonadales	135614|Xanthomonadales	U	Type II secretion system (T2SS), protein J	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,T2SSJ
k59_230246_1	1304865.JAGF01000001_gene168	1.11e-67	219.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4F0IS@85016|Cellulomonadaceae	201174|Actinobacteria	I	Malonate decarboxylase gamma subunit (MdcE)	pccB	GO:0003674,GO:0003824,GO:0003989,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009317,GO:0009987,GO:0015977,GO:0016020,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0030312,GO:0032787,GO:0032991,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:0071944,GO:0072329,GO:1901575,GO:1902494	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_230246_2	1713.JOFV01000008_gene3092	6.81e-08	52.8	2B2UP@1|root,31VF7@2|Bacteria,2GQMP@201174|Actinobacteria	201174|Actinobacteria	S	Acyl-CoA carboxylase epsilon subunit	-	-	-	-	-	-	-	-	-	-	-	-	ACC_epsilon
k59_1809863_1	1210884.HG799465_gene11952	2.51e-40	147.0	COG0626@1|root,COG0626@2|Bacteria,2IYKV@203682|Planctomycetes	203682|Planctomycetes	E	Cys Met metabolism	-	-	2.5.1.48,4.4.1.1	ko:K01739,ko:K01758	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
k59_1463422_1	75379.Tint_1810	6.74e-63	204.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2VKHP@28216|Betaproteobacteria,1KMYI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_580413_1	426355.Mrad2831_3774	2.74e-23	97.4	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2TQQ5@28211|Alphaproteobacteria,1JRV7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	TIGRFAM serine O-acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
k59_580413_2	1282876.BAOK01000001_gene3630	1.51e-17	82.0	COG2267@1|root,COG2267@2|Bacteria,1MUFB@1224|Proteobacteria,2U36E@28211|Alphaproteobacteria,4BRFW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
k59_1809875_2	762376.AXYL_04341	4.23e-17	80.5	COG2207@1|root,COG2207@2|Bacteria,1P1FH@1224|Proteobacteria,2VMY0@28216|Betaproteobacteria,3T2A9@506|Alcaligenaceae	28216|Betaproteobacteria	K	AraC family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
k59_759410_1	1249627.D779_4175	5.72e-13	68.9	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales	135613|Chromatiales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_759410_2	472759.Nhal_2770	1.75e-45	161.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales	135613|Chromatiales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_877623_1	396588.Tgr7_0539	5.06e-41	142.0	COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1RMSA@1236|Gammaproteobacteria,1X07Q@135613|Chromatiales	135613|Chromatiales	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_230284_1	1304284.L21TH_2159	6.46e-13	69.7	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,36K9Y@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_463183_1	1255043.TVNIR_3388	3.29e-85	263.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,1S0GF@1236|Gammaproteobacteria,1X0AW@135613|Chromatiales	135613|Chromatiales	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
k59_807281_2	765914.ThisiDRAFT_0067	1.28e-91	277.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1WWT0@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_1050894_1	1123073.KB899244_gene406	1.21e-52	181.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1S1HS@1236|Gammaproteobacteria,1X48P@135614|Xanthomonadales	135614|Xanthomonadales	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
k59_1580909_1	472759.Nhal_3820	1.16e-42	159.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
k59_1755087_1	631362.Thi970DRAFT_01084	8.61e-164	483.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1WXQF@135613|Chromatiales	135613|Chromatiales	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_1163218_1	1000565.METUNv1_03783	5.66e-38	145.0	COG4191@1|root,COG4191@2|Bacteria,1MU55@1224|Proteobacteria,2VIZD@28216|Betaproteobacteria,2KV0R@206389|Rhodocyclales	206389|Rhodocyclales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_699474_1	565045.NOR51B_2584	1.52e-09	57.8	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,1RP6J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2	rutB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0019740,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.1.110	ko:K09020	ko00240,ko01100,map00240,map01100	-	R09947,R09980	RC02737,RC02738	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_102,iECED1_1282.ECED1_1167,iUTI89_1310.UTI89_C1074	Isochorismatase
k59_699474_2	565045.NOR51B_868	5.61e-30	118.0	COG0697@1|root,COG0697@2|Bacteria,1MYHQ@1224|Proteobacteria,1S4AM@1236|Gammaproteobacteria,1JAUM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1809919_1	572477.Alvin_0279	1.24e-75	251.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,1WWRZ@135613|Chromatiales	135613|Chromatiales	M	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k59_463240_1	765912.Thimo_3614	3.39e-91	283.0	COG0028@1|root,COG0028@2|Bacteria,1R5ED@1224|Proteobacteria,1RR2R@1236|Gammaproteobacteria,1WXEV@135613|Chromatiales	135613|Chromatiales	H	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1699558_1	768671.ThimaDRAFT_0998	1.28e-51	176.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1WWU2@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1699558_2	765911.Thivi_3772	6.9e-35	127.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,1S2U7@1236|Gammaproteobacteria,1WWN0@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_1699560_2	1380346.JNIH01000005_gene3178	1.57e-49	164.0	COG2050@1|root,COG2050@2|Bacteria,2IKTU@201174|Actinobacteria	201174|Actinobacteria	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_1463488_2	1123377.AUIV01000003_gene1852	4.33e-21	92.4	COG0835@1|root,COG0835@2|Bacteria,1RCIR@1224|Proteobacteria,1S61F@1236|Gammaproteobacteria,1X5IW@135614|Xanthomonadales	135614|Xanthomonadales	NT	chemotaxis signal transduction protein	pilI	-	-	ko:K02659	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	CheW
k59_807329_1	1348114.OM33_03315	3.03e-22	99.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,2Q1G9@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
k59_759478_1	929558.SMGD1_1616	1.43e-06	53.9	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2YN4S@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	Na Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans
k59_230354_1	883078.HMPREF9695_03760	1.03e-31	119.0	COG0735@1|root,COG0735@2|Bacteria,1MZIW@1224|Proteobacteria,2U9G4@28211|Alphaproteobacteria,3JS2Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Belongs to the Fur family	MA20_23250	-	-	ko:K09823	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	FUR
k59_60384_1	862908.BMS_1128	1.85e-85	256.0	COG1432@1|root,COG1432@2|Bacteria,1QC1U@1224|Proteobacteria,42TAH@68525|delta/epsilon subdivisions,2WPYX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
k59_60384_2	443152.MDG893_02780	7.86e-36	126.0	COG5615@1|root,COG5615@2|Bacteria,1RH6D@1224|Proteobacteria,1S6S2@1236|Gammaproteobacteria,4685Z@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CopD
k59_177069_1	1453503.AU05_12135	1.2e-88	286.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1YFJI@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	CP	Domain related to MnhB subunit of Na+/H+ antiporter	phaA	-	1.6.5.3	ko:K00341,ko:K05559	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,3.D.1	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
k59_822864_1	1121935.AQXX01000103_gene1384	1e-140	414.0	COG3268@1|root,COG3268@2|Bacteria,1MVI3@1224|Proteobacteria,1RSCK@1236|Gammaproteobacteria,1XJ33@135619|Oceanospirillales	135619|Oceanospirillales	S	Saccharopine dehydrogenase NADP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
k59_1233790_1	1121396.KB892990_gene4480	6.05e-33	129.0	COG4191@1|root,COG4191@2|Bacteria,1P0U1@1224|Proteobacteria,42PTP@68525|delta/epsilon subdivisions,2WJ8U@28221|Deltaproteobacteria,2MIQ7@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_940992_1	77586.LPERR03G31630.2	6.05e-15	75.5	COG0159@1|root,KOG4175@2759|Eukaryota,37QAU@33090|Viridiplantae,3GCHM@35493|Streptophyta	35493|Streptophyta	E	Belongs to the TrpA family	-	GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009605,GO:0009606,GO:0009607,GO:0009617,GO:0009628,GO:0009629,GO:0009630,GO:0009719,GO:0009725,GO:0009735,GO:0009987,GO:0010033,GO:0016043,GO:0016053,GO:0016829,GO:0016830,GO:0016832,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0033036,GO:0033037,GO:0033554,GO:0033984,GO:0034641,GO:0042221,GO:0042401,GO:0042430,GO:0042435,GO:0042545,GO:0042742,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045229,GO:0046219,GO:0046394,GO:0046483,GO:0050896,GO:0051179,GO:0051641,GO:0051704,GO:0051707,GO:0051716,GO:0052386,GO:0052482,GO:0052542,GO:0052543,GO:0052544,GO:0052545,GO:0070727,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0098542,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_1057774_1	367299.JOEE01000008_gene506	3.76e-137	398.0	COG2230@1|root,COG2230@2|Bacteria,2GJ94@201174|Actinobacteria,4FEQA@85021|Intrasporangiaceae	201174|Actinobacteria	M	Cyclopropane-fatty-acyl-phospholipid synthase	cfa	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_1821509_2	546262.NEICINOT_04062	1.61e-10	61.2	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,2VSP2@28216|Betaproteobacteria,2KRBI@206351|Neisseriales	206351|Neisseriales	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
k59_118401_1	748247.AZKH_0625	2.18e-47	156.0	2CNK3@1|root,32SH9@2|Bacteria,1N02U@1224|Proteobacteria,2VUNW@28216|Betaproteobacteria,2KX0T@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of Unknown function (DUF2784)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2784
k59_1585883_1	880072.Desac_0500	2.89e-97	296.0	COG1804@1|root,COG1804@2|Bacteria,1NWFC@1224|Proteobacteria,4300F@68525|delta/epsilon subdivisions,2X2A6@28221|Deltaproteobacteria,2MRS4@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_882325_1	1267005.KB911266_gene1250	2.8e-65	209.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,3N7U4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_882325_2	391616.OA238_c40160	6.29e-22	93.2	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2UDDB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_999088_1	1121937.AUHJ01000007_gene1875	5.15e-27	105.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,46745@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18,3.5.4.4	ko:K00969,ko:K01488	ko00230,ko00760,ko01100,ko05340,map00230,map00760,map01100,map05340	M00115	R00137,R01560,R02556,R03005	RC00002,RC00477	ko00000,ko00001,ko00002,ko01000	-	-	iECUMN_1333.ECUMN_0733,iJN746.PP_4810,iPC815.YPO2607,iSbBS512_1146.SbBS512_E0612	CTP_transf_like
k59_999088_2	391615.ABSJ01000027_gene227	2.01e-42	142.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,1J6PI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
k59_646764_1	1042377.AFPJ01000054_gene1715	7.21e-82	262.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,1RRN4@1236|Gammaproteobacteria,4674P@72275|Alteromonadaceae	1236|Gammaproteobacteria	EU	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
k59_587998_1	331869.BAL199_28440	1.15e-101	304.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria,4BP7N@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
k59_999092_1	2340.JV46_08720	2.82e-107	328.0	COG0589@1|root,COG0730@1|root,COG0589@2|Bacteria,COG0730@2|Bacteria,1NBKV@1224|Proteobacteria,1SHMY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Universal stress protein family	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE,Usp
k59_999092_2	2340.JV46_08710	1.12e-13	65.1	2EGXE@1|root,329EB@2|Bacteria,1NIPX@1224|Proteobacteria,1SHV3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_882338_1	1267005.KB911259_gene3832	3.83e-57	191.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRCI@28211|Alphaproteobacteria,3N6JF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX1	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_529273_1	156889.Mmc1_2462	9.11e-12	64.7	COG0360@1|root,COG0360@2|Bacteria	2|Bacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	4.3.1.19	ko:K01754,ko:K02990	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,ko03010,map00260,map00290,map01100,map01110,map01130,map01200,map01230,map03010	M00178,M00570	R00220,R00996	RC00418,RC02600	br01610,ko00000,ko00001,ko00002,ko01000,ko03011,ko03029	-	-	-	Ribosomal_S6
k59_118416_1	1121405.dsmv_2619	1.16e-16	82.4	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,42NS9@68525|delta/epsilon subdivisions,2WJMJ@28221|Deltaproteobacteria,2MK0W@213118|Desulfobacterales	28221|Deltaproteobacteria	P	CorA-like Mg2+ transporter protein	corA	-	-	ko:K03284,ko:K16074	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3,1.A.35.4	-	-	CorA
k59_118416_2	469383.Cwoe_2511	5.62e-27	107.0	COG1023@1|root,COG1023@2|Bacteria,2I2DH@201174|Actinobacteria,4CPEH@84995|Rubrobacteria	84995|Rubrobacteria	G	6-phosphogluconate dehydrogenase, C-terminal domain	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
k59_1703375_1	1047013.AQSP01000087_gene1646	1.22e-80	268.0	COG0086@1|root,COG0086@2|Bacteria,2NNPR@2323|unclassified Bacteria	2|Bacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03046,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1527189_1	367299.JOEE01000006_gene893	1.66e-151	452.0	COG2366@1|root,COG2366@2|Bacteria,2GISQ@201174|Actinobacteria,4FER7@85021|Intrasporangiaceae	201174|Actinobacteria	S	penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_705491_1	864069.MicloDRAFT_00005150	1e-165	473.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria,1JVDJ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_1527196_2	1095772.CAHH01000047_gene152	1.16e-16	77.4	COG3945@1|root,COG3945@2|Bacteria,2GQQY@201174|Actinobacteria	201174|Actinobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
k59_1334_1	1049564.TevJSym_ad00070	1.89e-184	530.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1J4XI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_1468642_2	1120949.KB903294_gene3625	4.74e-22	91.7	COG3583@1|root,COG3583@2|Bacteria,2GRTZ@201174|Actinobacteria,4DEE6@85008|Micromonosporales	201174|Actinobacteria	S	G5	-	-	-	-	-	-	-	-	-	-	-	-	Excalibur,G5
k59_1293249_2	1169161.KB897729_gene1343	1.87e-42	150.0	COG1576@1|root,COG3832@1|root,COG1576@2|Bacteria,COG3832@2|Bacteria,2I3MI@201174|Actinobacteria	201174|Actinobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,MDMPI_N
k59_1762073_1	644282.Deba_0155	6.1e-09	59.7	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
k59_1762073_2	1167006.UWK_02600	2.66e-22	95.9	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MIWX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_353972_1	344747.PM8797T_07462	4.89e-77	244.0	COG0439@1|root,COG0439@2|Bacteria,2IWZV@203682|Planctomycetes	203682|Planctomycetes	I	Biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_764157_1	1173027.Mic7113_6242	4.12e-06	54.3	COG2319@1|root,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria,1H7HR@1150|Oscillatoriales	1117|Cyanobacteria	S	WD domain, G-beta repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	SpoIIE,TIR_2,WD40
k59_1293260_1	177437.HRM2_04530	9.54e-76	236.0	COG0727@1|root,COG0727@2|Bacteria,1RCRP@1224|Proteobacteria,42QP5@68525|delta/epsilon subdivisions,2WMQD@28221|Deltaproteobacteria,2MJI3@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_294488_1	1517681.HW45_23100	1.67e-193	588.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1XVUA@135623|Vibrionales	135623|Vibrionales	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1057828_1	452637.Oter_2235	8.82e-81	253.0	COG0460@1|root,COG0460@2|Bacteria,46TFC@74201|Verrucomicrobia,3K7MC@414999|Opitutae	414999|Opitutae	E	homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
k59_60472_1	880072.Desac_2159	1.63e-78	246.0	COG1533@1|root,COG1533@2|Bacteria,1NWJ9@1224|Proteobacteria,42P30@68525|delta/epsilon subdivisions,2WIPV@28221|Deltaproteobacteria,2MQE9@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	radical SAM domain protein	-	-	4.1.99.14	ko:K03716	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_118453_1	314264.ROS217_20137	3.35e-84	265.0	COG3660@1|root,COG3660@2|Bacteria,1R70U@1224|Proteobacteria,2TQWV@28211|Alphaproteobacteria,46P2E@74030|Roseovarius	28211|Alphaproteobacteria	M	Mitochondrial fission ELM1	-	-	-	ko:K07276	-	-	-	-	ko00000	-	-	-	Mito_fiss_Elm1
k59_353989_1	1198232.CYCME_0106	3.72e-59	196.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,45ZU4@72273|Thiotrichales	72273|Thiotrichales	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
k59_353989_2	1234364.AMSF01000016_gene1501	8.13e-10	58.9	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1S032@1236|Gammaproteobacteria,1X3H4@135614|Xanthomonadales	135614|Xanthomonadales	S	Possible lysine decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lysine_decarbox
k59_1821597_1	1380354.JIAN01000005_gene1589	9.53e-76	231.0	COG1392@1|root,COG1392@2|Bacteria,2GJME@201174|Actinobacteria,4F0VM@85016|Cellulomonadaceae	201174|Actinobacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_1293280_1	1500893.JQNB01000001_gene282	1.24e-14	71.2	2AQI0@1|root,31FQP@2|Bacteria,1RI31@1224|Proteobacteria,1S4IS@1236|Gammaproteobacteria,1X71C@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1116432_1	1111131.HMPREF1255_0298	2.08e-46	169.0	COG1331@1|root,COG1331@2|Bacteria,2IE03@201174|Actinobacteria,4DWN1@85009|Propionibacteriales	201174|Actinobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_588054_1	1260251.SPISAL_04995	2.16e-79	252.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,SNARE_assoc
k59_1527237_1	1122194.AUHU01000007_gene255	1.11e-57	184.0	COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,466ZE@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Belongs to the UPF0234 family	yajQ	GO:0000049,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
k59_1527237_2	1384054.N790_14300	1.51e-27	113.0	COG4772@1|root,COG4772@2|Bacteria,1MWDG@1224|Proteobacteria,1RQA5@1236|Gammaproteobacteria,1X5QP@135614|Xanthomonadales	135614|Xanthomonadales	P	receptor	-	-	-	ko:K16091	-	-	-	-	ko00000,ko02000	1.B.14.1.14	-	-	Plug,TonB_dep_Rec
k59_764173_1	1216966.BAUC01000015_gene508	1.51e-116	362.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Dehydrogenase E1 component	sucA	GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0030976,GO:0032991,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0046872,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iSSON_1240.SSON_0677,iYL1228.KPN_00732	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1762101_1	644283.Micau_1271	1.03e-87	282.0	COG2609@1|root,COG2609@2|Bacteria,2GND8@201174|Actinobacteria,4DC0M@85008|Micromonosporales	201174|Actinobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE_1	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_C,Transketolase_N
k59_177158_1	107636.JQNK01000009_gene3513	1.16e-164	476.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,370BU@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_60511_1	96561.Dole_1206	3.09e-19	82.0	COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,42SI7@68525|delta/epsilon subdivisions,2WPSJ@28221|Deltaproteobacteria,2MKCA@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Uncharacterized BCR, YaiI/YqxD family COG1671	yaiI	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
k59_999185_1	593907.Celgi_2417	3.82e-106	316.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4F0UZ@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_1644880_1	452637.Oter_2733	1.44e-73	240.0	COG0465@1|root,COG0465@2|Bacteria,46SB7@74201|Verrucomicrobia,3K7DV@414999|Opitutae	414999|Opitutae	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
k59_470640_1	1158182.KB905020_gene1679	8.56e-69	215.0	COG2518@1|root,COG2518@2|Bacteria,1REW0@1224|Proteobacteria,1SDW0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	TPMT
k59_882458_1	768671.ThimaDRAFT_1714	5.49e-93	286.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,1RQ65@1236|Gammaproteobacteria,1WWT1@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM FeS assembly protein SufB	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_646855_1	94624.Bpet0309	8.59e-127	365.0	COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,2VK6T@28216|Betaproteobacteria,3T37W@506|Alcaligenaceae	28216|Betaproteobacteria	U	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
k59_470646_1	335543.Sfum_3302	1.94e-81	259.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria,2MR5T@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_529372_1	572477.Alvin_0756	2.12e-28	109.0	COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,1S6FG@1236|Gammaproteobacteria,1WY34@135613|Chromatiales	135613|Chromatiales	S	pfam ammecr1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
k59_529372_2	243233.MCA0072	6.23e-48	161.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,1RQPK@1236|Gammaproteobacteria,1XEER@135618|Methylococcales	135618|Methylococcales	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
k59_822965_1	215803.DB30_1689	1.02e-30	122.0	COG4945@1|root,COG4945@2|Bacteria,1NYP6@1224|Proteobacteria,4394H@68525|delta/epsilon subdivisions,2X4AK@28221|Deltaproteobacteria,2YYMF@29|Myxococcales	28221|Deltaproteobacteria	G	C-terminal binding-module, SLH-like, of glucodextranase	-	-	-	-	-	-	-	-	-	-	-	-	Glucodextran_C
k59_1468713_1	395493.BegalDRAFT_3230	2.6e-45	153.0	COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,460DN@72273|Thiotrichales	72273|Thiotrichales	L	Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis	rnt	-	-	ko:K03683	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_T
k59_1175184_1	78245.Xaut_3898	1.35e-33	119.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2U7D8@28211|Alphaproteobacteria,3EZEH@335928|Xanthobacteraceae	28211|Alphaproteobacteria	I	Polyketide cyclase / dehydrase and lipid transport	pasT	-	-	ko:K18588	-	-	-	-	ko00000	-	-	-	Polyketide_cyc
k59_1175184_2	861208.AGROH133_05929	2.42e-70	221.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2TRP3@28211|Alphaproteobacteria,4B9M5@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_882481_1	471853.Bcav_0782	8.62e-46	160.0	COG3642@1|root,COG3642@2|Bacteria,2GIX0@201174|Actinobacteria	201174|Actinobacteria	T	Domain of unknown function (DUF4032)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4032,Kdo
k59_529379_1	1262914.BN533_00388	8.38e-59	196.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,4H2H6@909932|Negativicutes	909932|Negativicutes	V	Efflux ABC transporter permease protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1585984_2	292459.STH2369	0.000982	43.5	COG0500@1|root,COG2226@2|Bacteria,1U5XV@1239|Firmicutes,24A44@186801|Clostridia	186801|Clostridia	Q	Methyltransferase	arsM	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
k59_1293356_1	1499680.CCFE01000011_gene507	1.46e-25	106.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4H9NW@91061|Bacilli,1ZCU1@1386|Bacillus	91061|Bacilli	L	RNA-directed DNA polymerase (reverse transcriptase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_942366_1	768671.ThimaDRAFT_1475	3.03e-87	280.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,1RZMQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Recombinase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
k59_1410806_1	1479238.JQMZ01000001_gene957	2.9e-26	107.0	COG0019@1|root,COG0527@1|root,COG0019@2|Bacteria,COG0527@2|Bacteria,1MUA6@1224|Proteobacteria,2TQPB@28211|Alphaproteobacteria,43WZD@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	2.7.2.4,4.1.1.20	ko:K01586,ko:K12526	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00525,M00526,M00527	R00451,R00480	RC00002,RC00043,RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_1410806_2	1282876.BAOK01000001_gene1986	2.36e-58	197.0	28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,2U2TN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1329
k59_1822828_1	1234364.AMSF01000003_gene2426	9.17e-47	167.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,1X4QW@135614|Xanthomonadales	135614|Xanthomonadales	I	Cardiolipin synthase	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_883647_1	1286106.MPL1_05699	2.54e-79	241.0	COG3576@1|root,COG3576@2|Bacteria,1R8RC@1224|Proteobacteria,1S2GU@1236|Gammaproteobacteria,461U2@72273|Thiotrichales	72273|Thiotrichales	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
k59_1176048_1	1121934.AUDX01000013_gene1704	1.08e-07	52.4	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4FKZ0@85023|Microbacteriaceae	201174|Actinobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1176048_2	110319.CF8_0011	3.84e-38	139.0	COG0705@1|root,COG0705@2|Bacteria,2GJYG@201174|Actinobacteria,4DQ9T@85009|Propionibacteriales	201174|Actinobacteria	S	Rhomboid family	yggP	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid,zf-B_box
k59_1469536_1	227377.CBU_0609	7.18e-57	189.0	COG1577@1|root,COG1577@2|Bacteria,1RIKN@1224|Proteobacteria,1S678@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	GHMP kinases N terminal domain	-	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_11824_1	526222.Desal_2192	8.13e-85	262.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,42MRE@68525|delta/epsilon subdivisions,2WIP0@28221|Deltaproteobacteria,2M81I@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_69740_1	446471.Xcel_2768	9.36e-80	255.0	COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,2GJB4@201174|Actinobacteria,4F5MT@85017|Promicromonosporaceae	201174|Actinobacteria	CE	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Rieske
k59_891447_1	387093.SUN_2456	2.84e-13	71.2	COG1574@1|root,COG1574@2|Bacteria,1R53N@1224|Proteobacteria,42R2P@68525|delta/epsilon subdivisions,2YRFE@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1416777_1	1307759.JOMJ01000004_gene2450	2.4e-57	189.0	2DC6N@1|root,2ZD32@2|Bacteria,1Q0S4@1224|Proteobacteria,436UF@68525|delta/epsilon subdivisions,2X1IB@28221|Deltaproteobacteria,2MF4A@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_477076_1	471853.Bcav_1017	1.36e-17	80.1	COG1694@1|root,COG3956@2|Bacteria,2GNKC@201174|Actinobacteria	201174|Actinobacteria	S	PFAM MazG nucleotide pyrophosphohydrolase	mazG	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0022607,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0035539,GO:0042454,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0047693,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
k59_653346_1	472759.Nhal_2460	3.64e-20	91.3	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1WXD9@135613|Chromatiales	135613|Chromatiales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_653346_2	323848.Nmul_A0664	5.18e-72	236.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria,371TQ@32003|Nitrosomonadales	28216|Betaproteobacteria	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_183739_1	340177.Cag_1581	2.26e-62	202.0	COG0598@1|root,COG0598@2|Bacteria,1FEBZ@1090|Chlorobi	1090|Chlorobi	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284,ko:K16074	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3,1.A.35.4	-	-	CorA
k59_183739_2	547163.BN979_03337	2.19e-06	49.3	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,236R5@1762|Mycobacteriaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_363260_1	225849.swp_0608	1.11e-49	169.0	29SNM@1|root,30DU7@2|Bacteria,1RGQV@1224|Proteobacteria,1S54D@1236|Gammaproteobacteria,2QDYS@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2785)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2785
k59_1651603_1	408672.NBCG_04015	1.36e-87	271.0	COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria,4DP1E@85009|Propionibacteriales	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
k59_1302640_1	198628.Dda3937_03441	3.12e-66	213.0	COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,1RN28@1236|Gammaproteobacteria,2JDK9@204037|Dickeya	1236|Gammaproteobacteria	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs	dusA	GO:0002943,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	-	ko:K05539	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_950473_1	156889.Mmc1_0519	4.29e-46	165.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TS80@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1416789_2	90813.JQMT01000001_gene1935	8.22e-23	93.6	COG2738@1|root,COG2738@2|Bacteria,1RDJH@1224|Proteobacteria,1S4QY@1236|Gammaproteobacteria,461SZ@72273|Thiotrichales	72273|Thiotrichales	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K06973	-	-	-	-	ko00000	-	-	-	Zn_peptidase_2
k59_1830823_1	1121405.dsmv_1448	2.7e-101	298.0	COG1013@1|root,COG1013@2|Bacteria,1N0HY@1224|Proteobacteria,42MTM@68525|delta/epsilon subdivisions,2WJS6@28221|Deltaproteobacteria,2MIRW@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_950482_1	547163.BN979_02789	4.9e-09	56.6	COG5361@1|root,COG5361@2|Bacteria,2GKTA@201174|Actinobacteria,2379R@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_950482_2	711393.AYRX01000022_gene1074	2.09e-06	49.3	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria	201174|Actinobacteria	G	alpha amylase, catalytic	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_594462_1	1128421.JAGA01000004_gene2627	4.2e-53	182.0	COG0836@1|root,COG0836@2|Bacteria,2NP3C@2323|unclassified Bacteria	2|Bacteria	M	Mannose-6-phosphate isomerase	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_891481_1	95619.PM1_0228690	2.1e-32	121.0	COG1414@1|root,COG1414@2|Bacteria,1MXRJ@1224|Proteobacteria,1S251@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_301054_1	868595.Desca_2185	3.13e-73	233.0	COG0337@1|root,COG0337@2|Bacteria,1TPKZ@1239|Firmicutes,248H4@186801|Clostridia,25ZZM@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_1302654_1	1191523.MROS_1505	2.27e-09	62.8	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Lipase_GDSL_2,Pec_lyase
k59_1476523_1	196162.Noca_2407	4.88e-80	261.0	COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,4DP1M@85009|Propionibacteriales	201174|Actinobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_1533525_1	85643.Tmz1t_2462	2.06e-11	69.7	COG0558@1|root,COG0558@2|Bacteria,1QVT7@1224|Proteobacteria	1224|Proteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1065821_1	768066.HELO_1403	6.94e-82	253.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,1XH6Q@135619|Oceanospirillales	135619|Oceanospirillales	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
k59_183757_1	397945.Aave_0302	2.89e-102	308.0	COG1760@1|root,COG1760@2|Bacteria,1MUZN@1224|Proteobacteria,2VH8K@28216|Betaproteobacteria,4AA7J@80864|Comamonadaceae	28216|Betaproteobacteria	E	serine dehydratase beta chain	sdaA	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha,SDH_beta
k59_950490_1	1077972.ARGLB_094_00160	5.11e-45	161.0	COG3064@1|root,COG3271@1|root,COG3064@2|Bacteria,COG3271@2|Bacteria,2H973@201174|Actinobacteria	201174|Actinobacteria	M	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I36,Transglycosylas,VCBS
k59_1591954_1	1304865.JAGF01000001_gene1840	6.53e-52	182.0	COG1165@1|root,COG1165@2|Bacteria,2GMEB@201174|Actinobacteria,4F12X@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
k59_245611_1	314285.KT71_14399	9.9e-15	76.6	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1J7JI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	some members contain a von Willebrand factor type A (vWA	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_245611_2	1396141.BATP01000007_gene5749	8.17e-16	77.4	COG2304@1|root,COG2304@2|Bacteria,46XIS@74201|Verrucomicrobia,2IW0Y@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Domain of unknown function (DUF4381)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4381
k59_245611_3	768671.ThimaDRAFT_4341	4.79e-27	108.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,1WWB0@135613|Chromatiales	135613|Chromatiales	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
k59_125038_1	414684.RC1_2752	4.39e-82	255.0	COG4798@1|root,COG4798@2|Bacteria,1RHGZ@1224|Proteobacteria,2U7R8@28211|Alphaproteobacteria,2JUQC@204441|Rhodospirillales	204441|Rhodospirillales	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1065834_1	1123368.AUIS01000004_gene136	8.69e-85	267.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RYB4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter MnhD subunit	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M,Proton_antipo_N
k59_950499_1	1249627.D779_0079	9.01e-84	261.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1WVX9@135613|Chromatiales	135613|Chromatiales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_594472_1	28072.Nos7524_1286	8.42e-24	112.0	COG2931@1|root,COG3210@1|root,COG3291@1|root,COG3595@1|root,COG4070@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG3595@2|Bacteria,COG4070@2|Bacteria,1GHDQ@1117|Cyanobacteria,1HUA0@1161|Nostocales	1117|Cyanobacteria	Q	Domain of unknown function (DUF4114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114
k59_769509_1	313628.LNTAR_07694	2.12e-05	50.4	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
k59_769509_2	5932.XP_004030044.1	0.000767	42.7	COG0604@1|root,KOG1198@2759|Eukaryota	2759|Eukaryota	C	oxidoreductase activity	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044232,GO:0044233,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0055114	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
k59_183767_1	2340.JV46_03490	2.48e-17	75.9	COG3255@1|root,COG3255@2|Bacteria,1RI49@1224|Proteobacteria,1S38T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_183767_2	765911.Thivi_3956	5.96e-107	321.0	COG0845@1|root,COG0845@2|Bacteria,1MWZ9@1224|Proteobacteria,1RM91@1236|Gammaproteobacteria,1WX23@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
k59_1357598_1	472759.Nhal_1070	1.19e-76	241.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1WWHC@135613|Chromatiales	135613|Chromatiales	J	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
k59_1416825_1	365044.Pnap_2183	9.19e-103	325.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4A9J4@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1651639_1	247639.MGP2080_04565	2.36e-139	401.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RMNY@1236|Gammaproteobacteria,1J5HK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006566,GO:0006567,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0008652,GO:0008743,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046870,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	iEC042_1314.EC042_3926,iECUMN_1333.ECUMN_4133,iPC815.YPO0060	ADH_N,ADH_zinc_N
k59_1591966_1	497321.C664_00840	4.91e-47	170.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,2KV96@206389|Rhodocyclales	206389|Rhodocyclales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1067239_1	945543.VIBR0546_12412	4.48e-13	70.9	28HKI@1|root,2Z7VC@2|Bacteria,1MW0I@1224|Proteobacteria,1RQ5H@1236|Gammaproteobacteria,1XVWM@135623|Vibrionales	135623|Vibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_70927_1	519989.ECTPHS_13193	1.75e-08	54.7	COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,1RQES@1236|Gammaproteobacteria,1WXQ1@135613|Chromatiales	135613|Chromatiales	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
k59_70927_2	492774.JQMB01000004_gene2296	5.41e-16	82.0	COG3850@1|root,COG5001@1|root,COG3850@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2UQAK@28211|Alphaproteobacteria,4B728@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS,PAS_9
k59_595220_1	504472.Slin_3113	1.08e-25	111.0	COG0296@1|root,COG0296@2|Bacteria,4PKT8@976|Bacteroidetes,47M5D@768503|Cytophagia	976|Bacteroidetes	G	SMART alpha amylase catalytic sub domain	-	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
k59_951644_1	555793.WSK_0654	5.36e-60	201.0	COG0129@1|root,COG0129@2|Bacteria,1MU3T@1224|Proteobacteria,2TQNS@28211|Alphaproteobacteria,2K1X3@204457|Sphingomonadales	204457|Sphingomonadales	EG	Belongs to the IlvD Edd family	-	-	4.2.1.12	ko:K01690	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00008	R02036	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_477910_1	765912.Thimo_2787	9.62e-171	491.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1WX4J@135613|Chromatiales	135613|Chromatiales	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_1182701_1	1004785.AMBLS11_04085	9.59e-73	244.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,46ABP@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,STN,TonB_dep_Rec
k59_1358400_1	1049564.TevJSym_ak00590	4.01e-95	294.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1J5IS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_712947_1	930169.B5T_00687	1.86e-33	127.0	COG2267@1|root,COG2267@2|Bacteria,1R41P@1224|Proteobacteria,1T1IM@1236|Gammaproteobacteria,1XJIT@135619|Oceanospirillales	135619|Oceanospirillales	I	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_770197_1	1121405.dsmv_3234	7.92e-132	391.0	COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,2MHP4@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_1831972_1	396588.Tgr7_2714	3.05e-50	181.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1WWF6@135613|Chromatiales	135613|Chromatiales	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
k59_1652528_1	205922.Pfl01_1898	6.59e-15	73.2	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1YPZ7@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	GO:0001676,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0003824,GO:0003989,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006417,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0017148,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032787,GO:0032991,GO:0034248,GO:0034249,GO:0042759,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901576,GO:1902494,GO:1990234,GO:2000112,GO:2000113	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO2768,iUTI89_1310.UTI89_C2601	Carboxyl_trans
k59_1652528_2	243233.MCA2492	8.29e-30	117.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,1RMB0@1236|Gammaproteobacteria,1XEPM@135618|Methylococcales	135618|Methylococcales	H	PFAM Mur ligase	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_301837_1	1415780.JPOG01000001_gene2437	1.19e-87	287.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1X32B@135614|Xanthomonadales	135614|Xanthomonadales	P	COG2217 Cation transport ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_1067252_1	768671.ThimaDRAFT_4701	3.24e-71	238.0	COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria,1WX8D@135613|Chromatiales	135613|Chromatiales	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_477916_1	367299.JOEE01000008_gene385	3.61e-132	385.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4FE61@85021|Intrasporangiaceae	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HHH_5,IMS,IMS_C,IMS_HHH
k59_892665_1	319795.Dgeo_0886	3.34e-73	230.0	COG0479@1|root,COG0479@2|Bacteria,1WIEW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10,Fer4_8
k59_301838_1	1267005.KB911259_gene3716	9.2e-91	285.0	COG0480@1|root,COG0480@2|Bacteria,1MU2W@1224|Proteobacteria,2TYVK@28211|Alphaproteobacteria,3N7ME@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Elongation factor G, domain IV	MA20_05220	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_13610_1	1267005.KB911255_gene2454	5.76e-95	286.0	COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,2TS2V@28211|Alphaproteobacteria,3N6SB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	ABC 3 transport family	znuB	GO:0000006,GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0010035,GO:0010038,GO:0010043,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0042221,GO:0044464,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
k59_536755_1	1304872.JAGC01000003_gene2619	1.8e-22	88.2	COG0227@1|root,COG0227@2|Bacteria,1PTFN@1224|Proteobacteria,42V1S@68525|delta/epsilon subdivisions,2WR85@28221|Deltaproteobacteria,2MD8Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
k59_536755_2	1095772.CAHH01000039_gene990	2.95e-27	113.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria	201174|Actinobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1005177_2	768671.ThimaDRAFT_0944	4.23e-38	140.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,1WWYU@135613|Chromatiales	135613|Chromatiales	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
k59_1652534_1	1283300.ATXB01000001_gene912	1.91e-87	273.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1XDV5@135618|Methylococcales	135618|Methylococcales	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_1005180_1	1125863.JAFN01000001_gene2814	3.03e-83	252.0	COG1573@1|root,COG1573@2|Bacteria,1PIX8@1224|Proteobacteria,42P41@68525|delta/epsilon subdivisions,2WM40@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Uracil-DNA glycosylase superfamily	-	-	-	ko:K10800	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_13630_2	159087.Daro_3673	1.62e-21	93.6	COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,2VRU9@28216|Betaproteobacteria,2KVD0@206389|Rhodocyclales	206389|Rhodocyclales	H	Uroporphyrinogen-III synthase HemD	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
k59_1242789_1	395494.Galf_0807	1.7e-30	124.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,44VBM@713636|Nitrosomonadales	28216|Betaproteobacteria	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_477929_1	644282.Deba_0277	5.58e-97	291.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,42M1J@68525|delta/epsilon subdivisions,2WIQR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Cell shape determining protein MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_1831996_1	1124991.MU9_875	4.1e-33	134.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	MU	type I secretion outer membrane protein, TolC	tolC	GO:0002790,GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008104,GO:0008150,GO:0009279,GO:0009306,GO:0009987,GO:0010033,GO:0014070,GO:0015031,GO:0015075,GO:0015267,GO:0015288,GO:0015318,GO:0015562,GO:0015688,GO:0015711,GO:0015833,GO:0015850,GO:0015891,GO:0015893,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022838,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032940,GO:0032991,GO:0033036,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0042886,GO:0042930,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0046618,GO:0046903,GO:0047485,GO:0050896,GO:0051179,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098796,GO:1901678,GO:1902495,GO:1990195,GO:1990196,GO:1990281,GO:1990351	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	iAPECO1_1312.APECO1_3378,iEC042_1314.EC042_3326,iECOK1_1307.ECOK1_3463	OEP
k59_712968_1	1122613.ATUP01000001_gene1121	1.68e-64	215.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TR1I@28211|Alphaproteobacteria,43X05@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase	ilvI	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1303885_1	545276.KB898727_gene501	4.72e-79	262.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales	135613|Chromatiales	E	Vitamin B12 dependent methionine synthase activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_301845_1	1116472.MGMO_42c00080	6.82e-127	370.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RQBM@1236|Gammaproteobacteria,1XDMJ@135618|Methylococcales	135618|Methylococcales	E	PFAM Aminotransferase, class I	-	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_301845_2	768671.ThimaDRAFT_3755	2.95e-190	538.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1WWHB@135613|Chromatiales	135613|Chromatiales	E	homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
k59_595246_1	1206720.BAFQ01000281_gene5916	7.58e-90	275.0	COG3547@1|root,COG3547@2|Bacteria,2GNQB@201174|Actinobacteria,4FZBV@85025|Nocardiaceae	201174|Actinobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1477798_1	478801.Ksed_20450	9.03e-46	159.0	COG0524@1|root,COG0524@2|Bacteria,2GYHF@201174|Actinobacteria,1ZVXD@145357|Dermacoccaceae	201174|Actinobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_184674_1	425104.Ssed_2796	1.45e-40	154.0	COG3637@1|root,COG4625@1|root,COG3637@2|Bacteria,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,1T3XP@1236|Gammaproteobacteria,2QEUQ@267890|Shewanellaceae	1236|Gammaproteobacteria	M	outer membrane autotransporter barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347
k59_951692_1	1173264.KI913950_gene4565	6.39e-24	99.0	COG3415@1|root,COG3415@2|Bacteria,1G7IB@1117|Cyanobacteria,1HAS6@1150|Oscillatoriales	1117|Cyanobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_29,HTH_33
k59_654287_1	216142.LT40_11930	1.22e-80	256.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,1RP0M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the dehydration of galactarate to form 5- dehydro-4-deoxy-D-glucarate	-	-	4.2.1.42,4.2.1.7	ko:K01685,ko:K01708	ko00040,ko00053,ko01100,map00040,map00053,map01100	M00631	R01540,R05608	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
k59_1417778_1	1415780.JPOG01000001_gene1487	2.57e-27	109.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1X2ZV@135614|Xanthomonadales	135614|Xanthomonadales	M	Lipoprotein releasing system transmembrane protein	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_23533_1	1480694.DC28_02705	6.45e-12	70.5	COG0664@1|root,COG4191@1|root,COG0664@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	hoxI	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	EAL,FliG_C,HATPase_c,HisKA,cNMP_binding
k59_1598693_1	96561.Dole_0344	2.85e-74	243.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2MIW3@213118|Desulfobacterales	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB-2	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_425146_1	767029.HMPREF9154_3078	6.54e-87	275.0	COG1086@1|root,COG1086@2|Bacteria,2GIXM@201174|Actinobacteria,4DN3G@85009|Propionibacteriales	201174|Actinobacteria	M	Polysaccharide biosynthesis protein	capD	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
k59_1486197_1	519989.ECTPHS_06267	6.19e-27	116.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1WYS8@135613|Chromatiales	135613|Chromatiales	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE2,HAMP,Pkinase,sCache_3_2
k59_1841676_1	1125863.JAFN01000001_gene633	2.67e-89	278.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,42P15@68525|delta/epsilon subdivisions,2WK8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_7,rve
k59_484677_1	1260251.SPISAL_04740	3.37e-26	108.0	COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,1WW3V@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA	rlmL	-	2.1.1.173,2.1.1.264	ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
k59_484677_2	1390370.O203_06915	1.04e-26	110.0	COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1T3CM@1236|Gammaproteobacteria,1YHG2@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	L	GIY-YIG type nucleases (URI domain)	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,VRR_NUC
k59_80534_2	1114959.SZMC14600_01614	4.62e-07	54.3	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4DXBC@85010|Pseudonocardiales	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_775816_1	512565.AMIS_24850	1.69e-54	181.0	28NT3@1|root,2ZBRV@2|Bacteria,2IIC3@201174|Actinobacteria,4DD9K@85008|Micromonosporales	201174|Actinobacteria	S	YwiC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YwiC
k59_1010762_1	1517416.IDAT_03565	1.26e-111	338.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,1RPU5@1236|Gammaproteobacteria,2QFV9@267893|Idiomarinaceae	1236|Gammaproteobacteria	P	Sodium:sulfate symporter transmembrane region	sdcS	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
k59_1365204_1	935839.JAGJ01000011_gene412	8.31e-72	230.0	COG0438@1|root,COG0438@2|Bacteria,2ICB6@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_961308_1	110319.CF8_1676	6.95e-64	203.0	COG0582@1|root,COG0582@2|Bacteria,2I9B8@201174|Actinobacteria	201174|Actinobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
k59_1077896_1	882378.RBRH_03084	4.15e-56	187.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VK4X@28216|Betaproteobacteria,1K3SV@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_258120_1	631362.Thi970DRAFT_03277	4.22e-46	160.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,1WWB0@135613|Chromatiales	135613|Chromatiales	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
k59_1487133_1	765911.Thivi_0249	4.53e-128	378.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1RQ0H@1236|Gammaproteobacteria,1WWQC@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
k59_258126_1	1485545.JQLW01000005_gene932	4.44e-61	197.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria	1224|Proteobacteria	C	small subunit	hyaA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0048037,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_76,iUTI89_1310.UTI89_C1040	NiFe_hyd_SSU_C,Oxidored_q6
k59_1424816_1	446466.Cfla_2059	1.49e-22	95.9	2AR9G@1|root,31GJC@2|Bacteria,2HXWC@201174|Actinobacteria,4F1A4@85016|Cellulomonadaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4192)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4192
k59_1424816_2	935839.JAGJ01000005_gene2564	5.26e-116	349.0	COG0142@1|root,COG0142@2|Bacteria,2GJEK@201174|Actinobacteria,4F3UB@85017|Promicromonosporaceae	201174|Actinobacteria	H	Polyprenyl synthetase	crtE	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_1424816_3	1125863.JAFN01000001_gene2180	1.67e-06	55.5	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42M5C@68525|delta/epsilon subdivisions,2WJ54@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Lytic transglycosylase catalytic	mltD2	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_543475_1	1173264.KI913949_gene1506	4.29e-16	73.9	COG4634@1|root,COG4634@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1487139_1	1282360.ABAC460_01115	0.000477	48.1	COG5640@1|root,COG5640@2|Bacteria,1NFNT@1224|Proteobacteria,2U9RV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG5640 Secreted trypsin-like serine protease	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384,Peptidase_C14,Trypsin
k59_1717142_1	2340.JV46_21350	2.98e-28	111.0	28I2K@1|root,2Z86N@2|Bacteria,1R1GA@1224|Proteobacteria,1RRPU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1717142_2	1163617.SCD_n01952	3.25e-72	225.0	COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria	1224|Proteobacteria	P	part of a sulfur-relay system	tusE	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_661435_1	880072.Desac_0157	5.61e-67	218.0	COG1538@1|root,COG1538@2|Bacteria,1Q1F4@1224|Proteobacteria,42NUU@68525|delta/epsilon subdivisions,2WK3P@28221|Deltaproteobacteria,2MRMW@213462|Syntrophobacterales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_374127_2	67275.JOAP01000045_gene7726	6.35e-36	135.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria	201174|Actinobacteria	I	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta	pccB	GO:0003674,GO:0003824,GO:0003989,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009317,GO:0009987,GO:0015977,GO:0016020,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0030312,GO:0032787,GO:0032991,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:0071944,GO:0072329,GO:1901575,GO:1902494	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_775841_1	765913.ThidrDRAFT_2366	2.66e-57	196.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1WWBU@135613|Chromatiales	135613|Chromatiales	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_1487145_1	1385520.N802_07760	6.05e-53	181.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,2GK6D@201174|Actinobacteria,4FF28@85021|Intrasporangiaceae	201174|Actinobacteria	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumB	-	4.2.1.2,4.2.1.32	ko:K01676,ko:K01678,ko:K03780	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
k59_1487145_2	1283287.KB822576_gene3687	1.94e-65	203.0	COG0288@1|root,COG0288@2|Bacteria,2GM1M@201174|Actinobacteria,4DQAC@85009|Propionibacteriales	201174|Actinobacteria	P	Reversible hydration of carbon dioxide	cah	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
k59_1717146_1	455436.DS989810_gene252	1.44e-10	67.0	COG0612@1|root,COG0612@2|Bacteria,1NAH6@1224|Proteobacteria,1RNKC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Peptidase, M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_24430_1	590998.Celf_2874	2.44e-127	373.0	COG4584@1|root,COG4584@2|Bacteria,2HKD7@201174|Actinobacteria	201174|Actinobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_7,rve
k59_902397_1	305900.GV64_00785	1.58e-09	57.0	2CKE6@1|root,32ZEV@2|Bacteria,1NBRM@1224|Proteobacteria,1SCY3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Family of unknown function (DUF5329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5329
k59_902397_2	566466.NOR53_2748	6.95e-18	84.7	COG3568@1|root,COG3568@2|Bacteria,1RJZP@1224|Proteobacteria,1TH72@1236|Gammaproteobacteria,1JABN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_1717153_1	96561.Dole_0702	2.47e-49	178.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2MI5C@213118|Desulfobacterales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1599527_1	247634.GPB2148_2712	6.12e-81	251.0	COG2133@1|root,COG2133@2|Bacteria,1R74P@1224|Proteobacteria,1RSG0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_1541186_1	1713.JOFV01000007_gene2949	2.05e-160	461.0	COG0505@1|root,COG0505@2|Bacteria,2GKFA@201174|Actinobacteria,4F0XM@85016|Cellulomonadaceae	201174|Actinobacteria	EF	PFAM Carbamoyl-phosphate synthase small chain	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1383	CPSase_sm_chain,GATase
k59_1541186_2	1120946.AUBF01000004_gene1660	1.04e-09	57.8	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,4D31R@85005|Actinomycetales	201174|Actinobacteria	F	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_80612_1	381666.H16_B0760	2.25e-30	117.0	COG0406@1|root,COG0406@2|Bacteria,1RB0S@1224|Proteobacteria,2VJR8@28216|Betaproteobacteria,1K60Y@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_1252167_1	1121374.KB891585_gene1948	8.48e-141	422.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Na Pi-Cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans
k59_1252167_2	472759.Nhal_1157	3.47e-101	310.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1WWXH@135613|Chromatiales	135613|Chromatiales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1841753_1	330214.NIDE3807	9.38e-59	189.0	COG0396@1|root,COG0396@2|Bacteria,3J19D@40117|Nitrospirae	40117|Nitrospirae	O	ABC transporter	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
k59_1841753_2	439481.Aboo_0898	1.09e-42	154.0	COG0719@1|root,arCOG01716@2157|Archaea,2XXB6@28890|Euryarchaeota,3F3B7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K07033	-	-	-	-	ko00000	-	-	-	UPF0051
k59_1077960_1	1168034.FH5T_07160	5.41e-85	258.0	COG1018@1|root,COG1018@2|Bacteria,4PG0K@976|Bacteroidetes,2FSQF@200643|Bacteroidia	976|Bacteroidetes	C	Oxidoreductase NAD-binding domain	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
k59_1077960_2	28115.HR11_06790	1.35e-17	82.0	COG0820@1|root,COG0820@2|Bacteria,4NFH5@976|Bacteroidetes,2FPJH@200643|Bacteroidia,22WJ0@171551|Porphyromonadaceae	976|Bacteroidetes	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
k59_1189870_1	1041138.KB890222_gene903	1.25e-18	86.7	COG0300@1|root,COG0300@2|Bacteria,1R735@1224|Proteobacteria,2U27Q@28211|Alphaproteobacteria,4BBEZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1841757_2	95619.PM1_0206575	1.26e-29	110.0	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,1SC8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Belongs to the UPF0102 family	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
k59_720067_1	1120959.ATXF01000006_gene1701	2.03e-61	197.0	2CA7I@1|root,30E5G@2|Bacteria,2IJ78@201174|Actinobacteria,4FREA@85023|Microbacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_308619_1	1267005.KB911258_gene594	1.34e-61	204.0	28MUE@1|root,2ZB2B@2|Bacteria,1N3YU@1224|Proteobacteria,2TUD9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
k59_902429_1	1347342.BN863_13490	1.05e-72	236.0	COG1574@1|root,COG1574@2|Bacteria,4NFMV@976|Bacteroidetes,1HZ70@117743|Flavobacteriia	976|Bacteroidetes	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_258187_1	631362.Thi970DRAFT_01415	5.28e-42	149.0	COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,1S44I@1236|Gammaproteobacteria,1WYJP@135613|Chromatiales	135613|Chromatiales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_543522_1	1232437.KL662050_gene5289	1.64e-25	111.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WKC0@28221|Deltaproteobacteria,2MN70@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
k59_1487184_1	156889.Mmc1_2108	8.83e-64	204.0	COG2006@1|root,COG2006@2|Bacteria,1QMGX@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
k59_1487184_2	156889.Mmc1_2107	2.54e-53	184.0	COG0348@1|root,COG1152@1|root,COG0348@2|Bacteria,COG1152@2|Bacteria,1MY5M@1224|Proteobacteria,2TR0X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CK	COG3901 Regulator of nitric oxide reductase transcription	nosR	-	-	ko:K19339,ko:K19343	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind,Fer4_5
k59_374181_1	479431.Namu_4502	7.78e-23	102.0	COG1132@1|root,COG1132@2|Bacteria,2IKZX@201174|Actinobacteria	201174|Actinobacteria	V	(ABC) transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_720078_1	867900.Celly_2436	5.25e-28	118.0	COG1361@1|root,COG2911@1|root,COG3291@1|root,COG1361@2|Bacteria,COG2911@2|Bacteria,COG3291@2|Bacteria,4NS01@976|Bacteroidetes,1I3QG@117743|Flavobacteriia,1F8HT@104264|Cellulophaga	976|Bacteroidetes	M	InterPro IPR003367	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,CHU_C
k59_1841786_1	1121448.DGI_2572	0.000213	44.3	COG0314@1|root,COG0314@2|Bacteria,1N3AF@1224|Proteobacteria,42TPP@68525|delta/epsilon subdivisions,2WQK3@28221|Deltaproteobacteria,2MC27@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM molybdopterin biosynthesis MoaE protein	-	-	-	-	-	-	-	-	-	-	-	-	MoaE
k59_308637_1	187272.Mlg_0956	1.72e-74	246.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WXNN@135613|Chromatiales	135613|Chromatiales	F	PFAM glycosyl transferase family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_720079_1	768671.ThimaDRAFT_2784	2.26e-70	235.0	COG0834@1|root,COG1301@1|root,COG0834@2|Bacteria,COG1301@2|Bacteria,1P22C@1224|Proteobacteria,1RSGY@1236|Gammaproteobacteria,1WZZV@135613|Chromatiales	135613|Chromatiales	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3,SDF
k59_720079_2	360106.CFF8240_1753	0.000426	44.3	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,42Q71@68525|delta/epsilon subdivisions,2YQFJ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
k59_24477_1	926550.CLDAP_07460	3.96e-39	149.0	COG0068@1|root,COG0068@2|Bacteria,2G5QN@200795|Chloroflexi	200795|Chloroflexi	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_24477_2	2340.JV46_24290	7.81e-66	211.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1J9VF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Hydrogenase formation hypA family	hypD	GO:0003674,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0036211,GO:0042165,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070025,GO:0071704,GO:1901564	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
k59_191848_1	1499967.BAYZ01000028_gene1265	3.76e-58	193.0	COG1509@1|root,COG1509@2|Bacteria,2NNY6@2323|unclassified Bacteria	2|Bacteria	E	lysine 2,3-aminomutase activity	kamA	-	5.4.3.2	ko:K01843,ko:K19810	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000,ko03012	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
k59_1599569_1	471853.Bcav_3031	2.68e-10	57.8	2E4PN@1|root,32ZIA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1599569_2	1095767.CAHD01000138_gene2285	4.14e-60	190.0	COG2839@1|root,COG2839@2|Bacteria,2IQDE@201174|Actinobacteria,4F1BT@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein of unknown function (DUF456)	-	-	-	ko:K09793	-	-	-	-	ko00000	-	-	-	DUF456
k59_1487203_1	1121033.AUCF01000005_gene5267	8.33e-40	139.0	COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,2TUHN@28211|Alphaproteobacteria,2JS08@204441|Rhodospirillales	204441|Rhodospirillales	H	ABC-type tungstate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_1541221_1	1123288.SOV_3c00460	6.05e-36	135.0	arCOG03330@1|root,2Z82Q@2|Bacteria,1U584@1239|Firmicutes	1239|Firmicutes	H	PFAM Methanol-cobalamin methyltransferase B subunit	-	-	2.1.1.90	ko:K04480	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00356	R04384,R09098	RC00035,RC01144,RC01145,RC02440	ko00000,ko00001,ko00002,ko01000	-	-	-	MtaB
k59_661496_1	156889.Mmc1_2107	1.25e-75	240.0	COG0348@1|root,COG1152@1|root,COG0348@2|Bacteria,COG1152@2|Bacteria,1MY5M@1224|Proteobacteria,2TR0X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CK	COG3901 Regulator of nitric oxide reductase transcription	nosR	-	-	ko:K19339,ko:K19343	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind,Fer4_5
k59_1775660_1	1121405.dsmv_3530	9.05e-52	172.0	COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,42MAN@68525|delta/epsilon subdivisions,2WJBB@28221|Deltaproteobacteria,2MI3I@213118|Desulfobacterales	28221|Deltaproteobacteria	J	class II (D K and N)	genX	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
k59_720091_1	1265313.HRUBRA_02575	1.97e-16	77.8	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1J4PI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the GARS family	purD	GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01945,ko:K13713	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729	GARS_A,GARS_C,GARS_N
k59_720091_2	765914.ThisiDRAFT_1948	2.04e-56	189.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1WWGN@135613|Chromatiales	135613|Chromatiales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_1365297_1	1353537.TP2_14095	4.83e-77	234.0	COG2085@1|root,COG2085@2|Bacteria,1NI54@1224|Proteobacteria,2UAX3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
k59_961437_1	1049564.TevJSym_bc00390	2.5e-172	496.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,1JARP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Nickel-dependent hydrogenase	hydB	-	1.12.5.1,1.12.99.6	ko:K05922,ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_1487215_1	395965.Msil_0647	6.95e-08	52.8	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,2U95Q@28211|Alphaproteobacteria,3NBEF@45404|Beijerinckiaceae	28211|Alphaproteobacteria	J	methyltransferase activity	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
k59_1487215_2	1120956.JHZK01000001_gene3383	1.71e-57	182.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,2UBSV@28211|Alphaproteobacteria,1JP9M@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Ribosomal silencing factor during starvation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
k59_543545_1	649764.HMPREF0762_01669	2.91e-54	186.0	COG0635@1|root,COG0635@2|Bacteria,2GJ2W@201174|Actinobacteria,4CVC5@84998|Coriobacteriia	84998|Coriobacteriia	H	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_484772_1	1123503.KB908057_gene2395	3.38e-64	206.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,2TRXI@28211|Alphaproteobacteria,2KF0A@204458|Caulobacterales	204458|Caulobacterales	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
k59_484772_2	1210884.HG799466_gene12431	2.57e-18	83.6	COG0119@1|root,COG0119@2|Bacteria,2IX7Z@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_133188_1	1049564.TevJSym_ab00790	3.27e-50	175.0	COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1RPMH@1236|Gammaproteobacteria,1J85K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_1365309_2	1151126.AQYI01000003_gene583	2.99e-13	71.2	COG0433@1|root,COG0433@2|Bacteria,2IGPW@201174|Actinobacteria,4FR42@85023|Microbacteriaceae	201174|Actinobacteria	S	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_10
k59_601885_1	1232437.KL662001_gene4617	4.07e-32	124.0	COG0745@1|root,COG0745@2|Bacteria,1NE8H@1224|Proteobacteria,42NEH@68525|delta/epsilon subdivisions,2WK1M@28221|Deltaproteobacteria,2MHU4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2,Response_reg
k59_1424898_1	1123400.KB904758_gene2260	2.76e-195	558.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,45ZWP@72273|Thiotrichales	72273|Thiotrichales	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_1134511_1	1123070.KB899249_gene349	1.34e-217	618.0	COG1574@1|root,COG1574@2|Bacteria,46V0N@74201|Verrucomicrobia,2IVDG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1666147_1	443144.GM21_2830	4.75e-33	124.0	COG0730@1|root,COG0730@2|Bacteria,1RD5A@1224|Proteobacteria	1224|Proteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_1666147_2	382245.ASA_3090	4.51e-11	63.5	COG0303@1|root,COG1763@1|root,COG0303@2|Bacteria,COG1763@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1Y445@135624|Aeromonadales	135624|Aeromonadales	H	MoeA N-terminal region (domain I and II)	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MobB,MoeA_C,MoeA_N
k59_34796_1	1239962.C943_04519	1.39e-30	121.0	COG2939@1|root,COG2939@2|Bacteria,4NF48@976|Bacteroidetes,47KU0@768503|Cytophagia	976|Bacteroidetes	E	Serine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
k59_549554_1	265072.Mfla_1767	8.71e-89	276.0	COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,2VJYX@28216|Betaproteobacteria,2KMBT@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
k59_843460_1	519989.ECTPHS_01184	3.7e-111	335.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales	135613|Chromatiales	P	PFAM TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_1322663_1	348824.LPU83_3191	1.72e-169	486.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria,4B93D@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1431286_1	396588.Tgr7_0458	1.9e-73	242.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1WYS8@135613|Chromatiales	135613|Chromatiales	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	HAMP,HEAT_2,Pkinase,sCache_3_2
k59_911437_1	439235.Dalk_0681	2.43e-160	469.0	COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria,2MIRV@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit	-	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
k59_1134517_1	314285.KT71_02627	3.78e-57	204.0	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S0KQ@1236|Gammaproteobacteria,1J82F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1605502_1	373994.Riv7116_2631	9.22e-16	82.4	COG2931@1|root,COG2931@2|Bacteria,1G1I0@1117|Cyanobacteria,1HIHD@1161|Nostocales	1117|Cyanobacteria	Q	Hemolysin-type calcium-binding repeat (2 copies)	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	Cadherin,Calx-beta,DUF4347,HemolysinCabind,Lectin_C,P_proprotein,Peptidase_S8,VWA
k59_608251_2	1037409.BJ6T_62280	2.67e-55	177.0	2A6HJ@1|root,30VAV@2|Bacteria,1R8I0@1224|Proteobacteria,2TV0B@28211|Alphaproteobacteria,3JV9W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1196259_1	2340.JV46_17370	1.1e-99	297.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1J4Z2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666	ATP-synt_A
k59_1196259_2	1123393.KB891332_gene2797	7.13e-39	130.0	COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,2VTY0@28216|Betaproteobacteria,1KRWR@119069|Hydrogenophilales	119069|Hydrogenophilales	C	ATP synthase subunit C	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_89622_1	1089545.KB913037_gene326	3.59e-12	68.6	COG0596@1|root,COG0596@2|Bacteria,2GNFU@201174|Actinobacteria,4E4M0@85010|Pseudonocardiales	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1196263_1	768671.ThimaDRAFT_2533	1.57e-102	307.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1WW0A@135613|Chromatiales	135613|Chromatiales	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1850926_1	754476.Q7A_1353	5.35e-93	291.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,45ZNG@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses	nadE	-	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_1666164_1	318161.Sden_3360	1.19e-162	464.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,2Q9Q5@267890|Shewanellaceae	1236|Gammaproteobacteria	L	transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_843482_1	1123393.KB891326_gene128	6.3e-97	288.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,2VJKH@28216|Betaproteobacteria,1KSKW@119069|Hydrogenophilales	119069|Hydrogenophilales	KO	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
k59_1016171_1	743718.Isova_2504	9.75e-106	313.0	COG0462@1|root,COG0462@2|Bacteria,2GJ9S@201174|Actinobacteria,4F3X7@85017|Promicromonosporaceae	201174|Actinobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_1322695_1	351348.Maqu_3035	4.06e-125	371.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,464EV@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_197881_1	5039.XP_002625179.1	9.65e-05	50.1	COG0484@1|root,KOG0550@2759|Eukaryota,38CD1@33154|Opisthokonta,3NV1Y@4751|Fungi,3QQ9D@4890|Ascomycota,20BDM@147545|Eurotiomycetes,3B2PK@33183|Onygenales	4751|Fungi	O	domain-containing protein	-	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0030544,GO:0031072,GO:0051084,GO:0051085,GO:0061077	-	ko:K09527	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
k59_549580_1	321327.CYA_1334	1.67e-116	346.0	COG0604@1|root,COG0604@2|Bacteria,1FZW8@1117|Cyanobacteria,1GZNP@1129|Synechococcus	1117|Cyanobacteria	C	Oxidoreductase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
k59_34853_1	1276920.ADIAG_00624	3.44e-17	79.7	COG0582@1|root,COG0582@2|Bacteria,2I9B8@201174|Actinobacteria	201174|Actinobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
k59_34853_2	1292020.H483_0118620	1.78e-91	278.0	COG4974@1|root,COG4974@2|Bacteria,2I9JH@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_911474_1	56780.SYN_01331	1.28e-59	206.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,2MQYI@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Carbohydrate phosphorylase	-	-	2.4.1.1,2.4.1.11	ko:K00688,ko:K16153	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R00292,R02111	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT3,GT35	-	DUF3417,Phosphorylase
k59_970498_1	1304865.JAGF01000001_gene1598	4.66e-111	327.0	COG2116@1|root,COG2116@2|Bacteria,2I8DX@201174|Actinobacteria	201174|Actinobacteria	P	Formate nitrite transporter	-	-	-	-	-	-	-	-	-	-	-	-	Form_Nir_trans
k59_268465_1	998674.ATTE01000001_gene366	2.06e-18	90.1	COG0642@1|root,COG2205@2|Bacteria,1QTVU@1224|Proteobacteria,1RPFY@1236|Gammaproteobacteria,460R4@72273|Thiotrichales	72273|Thiotrichales	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07637	ko01503,ko02020,map01503,map02020	M00444,M00709,M00721,M00723,M00724,M00744	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HATPase_c
k59_1850948_1	266264.Rmet_5781	1.21e-61	198.0	2E3FB@1|root,32YE4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1086158_1	558884.JRGM01000135_gene1177	9.42e-66	215.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1Y3XY@135624|Aeromonadales	135624|Aeromonadales	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K10912	ko02020,ko02024,ko05111,map02020,map02024,map05111	M00513	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1016185_1	1125718.HMPREF1318_2488	1.3e-22	103.0	COG3147@1|root,COG3147@2|Bacteria,2HC8A@201174|Actinobacteria,4D375@85005|Actinomycetales	201174|Actinobacteria	S	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1322721_1	1121405.dsmv_1534	2.31e-87	275.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2WK05@28221|Deltaproteobacteria,2MHS3@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
k59_608280_1	768671.ThimaDRAFT_0812	9.55e-49	164.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,1RN7C@1236|Gammaproteobacteria,1WWZ1@135613|Chromatiales	135613|Chromatiales	S	PFAM ATPase associated with various cellular activities	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
k59_608280_2	1049564.TevJSym_bg00280	1.13e-53	172.0	2C0CP@1|root,32SP5@2|Bacteria,1N5DU@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_608280_3	1049564.TevJSym_bg00250	1.89e-05	45.8	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,1J4NX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	von Willebrand factor (vWF) type A domain	norD	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_2
k59_197896_1	1238182.C882_0229	7.85e-21	92.8	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2U6EY@28211|Alphaproteobacteria,2JRWX@204441|Rhodospirillales	204441|Rhodospirillales	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_1547913_1	243231.GSU0068	4.21e-29	109.0	2EE9W@1|root,3384B@2|Bacteria,1NCE1@1224|Proteobacteria,42VUH@68525|delta/epsilon subdivisions,2WSA1@28221|Deltaproteobacteria,43V30@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2
k59_1606086_1	754477.Q7C_1713	4.12e-73	228.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,460E7@72273|Thiotrichales	72273|Thiotrichales	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1431980_1	367299.JOEE01000014_gene932	1.34e-76	255.0	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,4FE8P@85021|Intrasporangiaceae	201174|Actinobacteria	S	UPF0182 protein	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_432849_1	1123368.AUIS01000008_gene2228	5.78e-22	95.5	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,2NCCU@225057|Acidithiobacillales	225057|Acidithiobacillales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_432849_2	1198232.CYCME_0834	9.35e-16	80.5	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,45ZVV@72273|Thiotrichales	1236|Gammaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_1666843_1	446471.Xcel_2217	6.05e-110	332.0	COG0433@1|root,COG0433@2|Bacteria,2GM12@201174|Actinobacteria,4F3GJ@85017|Promicromonosporaceae	201174|Actinobacteria	S	Domain of unknown function DUF87	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
k59_1852123_1	1123401.JHYQ01000014_gene879	9.89e-56	184.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,1RZ45@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Metallophosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
k59_36008_1	590998.Celf_0031	1.31e-66	218.0	COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria,4F0UK@85016|Cellulomonadaceae	201174|Actinobacteria	M	Penicillin binding protein transpeptidase domain	pbpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
k59_668185_1	1349820.M707_07855	1.12e-56	192.0	COG3356@1|root,COG3356@2|Bacteria,2IP4G@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Neutral alkaline nonlysosomal ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
k59_36009_1	1049564.TevJSym_ao00280	1.02e-60	209.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1224|Proteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_36009_2	76114.ebA1142	5.91e-33	124.0	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2VHBC@28216|Betaproteobacteria,2KUFJ@206389|Rhodocyclales	206389|Rhodocyclales	S	phosphotransferase related to Ser Thr protein kinases	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
k59_491694_1	768671.ThimaDRAFT_3947	3.27e-21	90.1	COG3091@1|root,COG3091@2|Bacteria,1N07A@1224|Proteobacteria,1S9E8@1236|Gammaproteobacteria,1WZ2K@135613|Chromatiales	135613|Chromatiales	S	SprT homologues.	-	-	-	ko:K02742	-	-	-	-	ko00000	-	-	-	SprT-like,Zn_ribbon_SprT
k59_491694_2	765912.Thimo_1136	2.54e-17	81.6	COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,1WW1A@135613|Chromatiales	135613|Chromatiales	S	PFAM Succinylglutamate desuccinylase Aspartoacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
k59_1852140_1	933262.AXAM01000043_gene1174	1.46e-08	55.8	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2WJVZ@28221|Deltaproteobacteria,2MIT4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Elongation factor Tu domain 2	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_1087005_2	797209.ZOD2009_13017	1.91e-12	73.6	COG0076@1|root,arCOG00027@2157|Archaea,2Y37G@28890|Euryarchaeota,23ZDQ@183963|Halobacteria	183963|Halobacteria	E	COG0076 Glutamate decarboxylase and related PLP-dependent proteins	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
k59_1724244_1	440512.C211_03570	6.46e-09	59.7	COG4970@1|root,COG4970@2|Bacteria	2|Bacteria	NU	protein transport across the cell outer membrane	fimT	-	-	ko:K08084	-	-	-	-	ko00000,ko02044	3.A.15.2	-	-	GspH,N_methyl
k59_1782464_1	1003195.SCAT_5178	4.79e-26	110.0	COG0545@1|root,COG0545@2|Bacteria,2GJK2@201174|Actinobacteria	201174|Actinobacteria	O	Peptidyl-prolyl cis-trans isomerase	fkbB	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
k59_1782464_2	358823.DF19_24330	3.49e-41	146.0	COG1609@1|root,COG1609@2|Bacteria,2GJBJ@201174|Actinobacteria	201174|Actinobacteria	K	lacI family	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
k59_384374_2	1000565.METUNv1_03646	1.38e-57	184.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,2VSQF@28216|Betaproteobacteria,2KWIK@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the CinA family	-	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
k59_198560_2	870187.Thini_3850	1.15e-35	132.0	COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,460J3@72273|Thiotrichales	72273|Thiotrichales	J	Elongation factor P--(R)-beta-lysine ligase	-	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
k59_1372024_1	446471.Xcel_1217	1.86e-60	204.0	COG1185@1|root,COG1185@2|Bacteria,2GIT2@201174|Actinobacteria,4F40I@85017|Promicromonosporaceae	201174|Actinobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_1372024_2	1043493.BBLU01000006_gene2090	2.94e-12	66.6	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the peptidase M16 family	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_139973_1	158189.SpiBuddy_2313	2.34e-114	345.0	COG1894@1|root,COG1894@2|Bacteria,2J5MT@203691|Spirochaetes	203691|Spirochaetes	C	NADH ubiquinone oxidoreductase NADH-binding (51 kD) subunit	-	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_1261244_1	1038860.AXAP01000002_gene4721	7.18e-27	111.0	COG3659@1|root,COG3659@2|Bacteria,1QIBX@1224|Proteobacteria,2VFW6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Carbohydrate-selective porin, OprB family	-	-	-	-	-	-	-	-	-	-	-	-	OprB
k59_971721_1	472759.Nhal_0092	6.01e-86	280.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWNH@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_315880_1	1454004.AW11_02394	1.92e-97	296.0	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VHA3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Phospholipase, patatin family	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_491711_2	215803.DB30_2651	2.56e-32	126.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2YUST@29|Myxococcales	28221|Deltaproteobacteria	P	Transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_608938_1	1396141.BATP01000040_gene2127	1.3e-58	205.0	COG0515@1|root,COG0515@2|Bacteria,46UX7@74201|Verrucomicrobia,2IVEF@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_432891_1	1408224.SAMCCGM7_c6624	1.11e-95	293.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,4BHQJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_491713_1	1415778.JQMM01000001_gene2044	1.64e-70	232.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1J4U2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_1495700_1	706587.Desti_5305	8.72e-96	287.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,42TGK@68525|delta/epsilon subdivisions,2WNGS@28221|Deltaproteobacteria,2MRXP@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Prolyl oligopeptidase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4
k59_844184_2	69042.WH5701_01855	3.03e-138	406.0	COG5361@1|root,COG5361@2|Bacteria,1G1YW@1117|Cyanobacteria,1GYS9@1129|Synechococcus	1117|Cyanobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_668212_1	269799.Gmet_0133	4.1e-67	225.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2WJG7@28221|Deltaproteobacteria,43STK@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_36054_1	742727.HMPREF9447_03934	3.11e-63	213.0	COG1148@1|root,COG1148@2|Bacteria,4NI95@976|Bacteroidetes,2FRRV@200643|Bacteroidia,4ANZK@815|Bacteroidaceae	976|Bacteroidetes	C	Glucose inhibited division protein A	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Fer4,Fer4_7,HI0933_like,Pyr_redox_2
k59_1135135_1	525897.Dbac_2498	2.92e-57	185.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M9C@68525|delta/epsilon subdivisions,2WJ75@28221|Deltaproteobacteria,2M8GA@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_1087048_1	1304865.JAGF01000001_gene2766	5.99e-152	442.0	COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,4F0KR@85016|Cellulomonadaceae	201174|Actinobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	GO:0008150,GO:0040007	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_1087048_2	1064537.AGSO01000013_gene952	1.76e-25	97.1	COG0721@1|root,COG0721@2|Bacteria,2IQJN@201174|Actinobacteria,4FCXD@85020|Dermabacteraceae	201174|Actinobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
k59_1666893_2	105559.Nwat_1458	6.78e-34	127.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1WWGC@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1608842_1	933262.AXAM01000030_gene797	2.33e-31	118.0	COG0289@1|root,COG0289@2|Bacteria,1QB39@1224|Proteobacteria,42NRC@68525|delta/epsilon subdivisions,2WJGM@28221|Deltaproteobacteria,2MJ2I@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the DapB family	-	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
k59_611891_1	2074.JNYD01000002_gene5541	1.43e-96	299.0	COG1140@1|root,COG1140@2|Bacteria,2GJ8P@201174|Actinobacteria,4DYH1@85010|Pseudonocardiales	201174|Actinobacteria	C	Nitrate reductase beta subunit	narH	-	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Fer4_11,Nitr_red_bet_C
k59_784344_1	1126627.BAWE01000004_gene2586	3.2e-05	50.1	COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,2TRD2@28211|Alphaproteobacteria,3JSF9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Transglycosylase SLT domain	MA20_01345	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,SLT_2
k59_435820_1	743718.Isova_2230	4.25e-115	353.0	COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4F5ZR@85017|Promicromonosporaceae	201174|Actinobacteria	C	Molydopterin dinucleotide binding domain	nasC	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_977103_1	1298863.AUEP01000001_gene1023	1.68e-09	58.9	arCOG10607@1|root,30Y0T@2|Bacteria,2I8NG@201174|Actinobacteria,4DW1P@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_977103_2	345341.KUTG_05421	6.89e-57	191.0	COG0076@1|root,COG0076@2|Bacteria,2GKIH@201174|Actinobacteria,4DXRW@85010|Pseudonocardiales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	gadB	-	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
k59_553227_1	652103.Rpdx1_4673	3.73e-65	206.0	COG1692@1|root,COG1692@2|Bacteria,1MW12@1224|Proteobacteria,2TS4S@28211|Alphaproteobacteria,3JQZG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	YmdB-like protein	MA20_17970	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
k59_553227_2	349102.Rsph17025_0295	6.7e-27	103.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,2UBY4@28211|Alphaproteobacteria,1FBSR@1060|Rhodobacter	28211|Alphaproteobacteria	H	PFAM 5-formyltetrahydrofolate cyclo-ligase	MA20_17975	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
k59_39864_1	349102.Rsph17025_0741	3.86e-46	152.0	COG2963@1|root,COG2963@2|Bacteria,1RCDZ@1224|Proteobacteria,2U9ZS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_1434936_1	1121889.AUDM01000010_gene593	2.04e-19	89.4	COG1446@1|root,COG1446@2|Bacteria,4NF1U@976|Bacteroidetes,1HXC4@117743|Flavobacteriia,2P02Z@237|Flavobacterium	976|Bacteroidetes	E	Asparaginase	-	-	3.4.19.5,3.5.1.1	ko:K01424,ko:K13051	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000,ko01002	-	-	-	Asparaginase_2
k59_1434936_2	1313421.JHBV01000039_gene2731	4.39e-36	136.0	COG1225@1|root,COG1225@2|Bacteria,4NN6C@976|Bacteroidetes	976|Bacteroidetes	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_389728_3	713586.KB900536_gene511	3.72e-64	201.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,1WY89@135613|Chromatiales	135613|Chromatiales	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	-	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
k59_977115_1	1238190.AMQY01000017_gene1424	8.15e-47	173.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1XIF3@135619|Oceanospirillales	135619|Oceanospirillales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_671069_1	367299.JOEE01000004_gene1432	4.46e-94	286.0	COG1104@1|root,COG1104@2|Bacteria,2GJ2B@201174|Actinobacteria,4FF85@85021|Intrasporangiaceae	201174|Actinobacteria	E	Aminotransferase	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5,TusA
k59_977120_1	179408.Osc7112_1603	4.16e-17	88.6	COG2831@1|root,COG2831@2|Bacteria,1G03B@1117|Cyanobacteria,1H7Y8@1150|Oscillatoriales	1117|Cyanobacteria	U	Hemolysin activation secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	POTRA_2,ShlB
k59_1374809_1	373994.Riv7116_2163	1e-10	66.6	COG0438@1|root,COG2148@1|root,COG0438@2|Bacteria,COG2148@2|Bacteria,1GIW0@1117|Cyanobacteria,1HPPK@1161|Nostocales	1117|Cyanobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_2,Glycos_transf_1
k59_1374810_2	765911.Thivi_0538	1.48e-73	236.0	COG2267@1|root,COG2267@2|Bacteria,1QTZP@1224|Proteobacteria,1RPB9@1236|Gammaproteobacteria,1X08Q@135613|Chromatiales	135613|Chromatiales	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
k59_1550732_1	1281779.H009_05563	2.97e-133	402.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,4B8ZJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_1728007_2	1101188.KI912155_gene3607	2.06e-32	123.0	COG1131@1|root,COG1131@2|Bacteria,2GN8P@201174|Actinobacteria,1WCH5@1268|Micrococcaceae	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_319591_1	273068.TTE1406	4.31e-05	44.7	COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,24HWS@186801|Clostridia,42FRZ@68295|Thermoanaerobacterales	186801|Clostridia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_319591_2	1249627.D779_1887	1.61e-81	250.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,1WX0N@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_1330654_2	1267005.KB911260_gene3453	3.45e-79	256.0	COG2200@1|root,COG2200@2|Bacteria,1MU4F@1224|Proteobacteria,2TU9M@28211|Alphaproteobacteria,3N7EJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	MA20_05620	-	-	ko:K13593	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	EAL
k59_978440_1	1266925.JHVX01000004_gene1249	1.26e-59	207.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,373XN@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
k59_1670541_1	864051.BurJ1DRAFT_1742	2.52e-43	160.0	COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,2VZB4@28216|Betaproteobacteria,1KN0Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_495329_1	452863.Achl_3276	3.35e-27	101.0	COG1917@1|root,COG1917@2|Bacteria,2IFSF@201174|Actinobacteria	201174|Actinobacteria	IQ	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_495329_2	215803.DB30_5408	7.18e-29	112.0	COG0599@1|root,COG1917@1|root,COG0599@2|Bacteria,COG1917@2|Bacteria,1RH1V@1224|Proteobacteria,42TDM@68525|delta/epsilon subdivisions,2WP8D@28221|Deltaproteobacteria,2YV8Y@29|Myxococcales	28221|Deltaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	CMD,Cupin_2
k59_1375518_1	1131814.JAFO01000001_gene514	2.68e-28	106.0	COG1017@1|root,COG1017@2|Bacteria,1QVJP@1224|Proteobacteria,2U5M6@28211|Alphaproteobacteria,3EZPA@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	Belongs to the globin family	MA20_17055	-	1.14.12.17	ko:K05916	ko05132,map05132	-	-	-	ko00000,ko00001,ko01000	-	-	-	Globin
k59_1499536_1	330214.NIDE0210	1.57e-96	295.0	COG2907@1|root,COG2907@2|Bacteria	2|Bacteria	S	Flavin containing amine oxidoreductase	-	-	-	ko:K06954	-	-	-	-	ko00000	-	-	-	Amino_oxidase,NAD_binding_8
k59_1499536_2	270374.MELB17_13727	1.06e-45	156.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RM88@1236|Gammaproteobacteria,465C3@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	desaturase	desC	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
k59_1200575_1	1122182.KB903835_gene4543	2.59e-99	298.0	COG3177@1|root,COG3177@2|Bacteria,2GN3K@201174|Actinobacteria,4DJ7N@85008|Micromonosporales	201174|Actinobacteria	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N
k59_1858938_2	1122611.KB903966_gene5056	1.06e-44	159.0	COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria,4EJT5@85012|Streptosporangiales	201174|Actinobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_319609_1	1458427.BAWN01000001_gene4	2.39e-29	118.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,2VHKV@28216|Betaproteobacteria,4AD4Y@80864|Comamonadaceae	28216|Betaproteobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_391029_1	391615.ABSJ01000029_gene1935	8.86e-61	195.0	COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,1RMYN@1236|Gammaproteobacteria,1JAGH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_730351_1	1123393.KB891326_gene42	1.98e-200	622.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2VKDG@28216|Betaproteobacteria,1KSRI@119069|Hydrogenophilales	119069|Hydrogenophilales	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
k59_919344_1	196162.Noca_1674	1.82e-36	134.0	28NT3@1|root,2ZBRV@2|Bacteria,2IIC3@201174|Actinobacteria	201174|Actinobacteria	S	YwiC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YwiC
k59_97589_1	519989.ECTPHS_13238	3e-115	335.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,1WW17@135613|Chromatiales	135613|Chromatiales	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_1670551_1	1265313.HRUBRA_01479	6.59e-137	399.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	JD73_00825	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1670551_2	525897.Dbac_1547	3.74e-16	78.6	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,42MJT@68525|delta/epsilon subdivisions,2WJ7W@28221|Deltaproteobacteria,2M8QV@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_1785625_1	1415778.JQMM01000001_gene1715	1.5e-30	119.0	COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,1J6DG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	GO:0008150,GO:0009314,GO:0009628,GO:0050896	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
k59_1609591_1	670307.HYPDE_30048	4.53e-33	124.0	COG0492@1|root,COG0492@2|Bacteria,1MW14@1224|Proteobacteria,2TSKU@28211|Alphaproteobacteria,3N6H2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Ferredoxin--NADP reductase	MA20_08170	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
k59_1728032_1	1004785.AMBLS11_17420	2.69e-85	281.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464AK@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1265118_2	1415778.JQMM01000001_gene1138	1.94e-67	213.0	COG0811@1|root,COG0811@2|Bacteria,1NXZ9@1224|Proteobacteria,1S154@1236|Gammaproteobacteria,1J4YC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	COG0811 Biopolymer transport proteins	-	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
k59_847788_1	1121448.DGI_2135	4.32e-40	149.0	COG0477@1|root,COG2814@2|Bacteria,1R9V9@1224|Proteobacteria,42Q1C@68525|delta/epsilon subdivisions,2WK7P@28221|Deltaproteobacteria,2M8DI@213115|Desulfovibrionales	28221|Deltaproteobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
k59_319620_1	880072.Desac_0544	1.81e-57	202.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MSJC@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	por	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_97604_1	1411123.JQNH01000001_gene1041	1.04e-98	298.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2TQPA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_1375541_2	1232437.KL662001_gene4532	5.14e-31	115.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,42NV2@68525|delta/epsilon subdivisions,2WNJ1@28221|Deltaproteobacteria,2MJKX@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_978505_1	765911.Thivi_0551	1.14e-166	478.0	COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria,1WXQI@135613|Chromatiales	135613|Chromatiales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8
k59_495356_1	935548.KI912159_gene965	3.11e-23	103.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS,PAS_4,PAS_9
k59_319625_1	1123073.KB899241_gene2778	6.26e-38	134.0	COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,1S6QS@1236|Gammaproteobacteria,1X6BT@135614|Xanthomonadales	135614|Xanthomonadales	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
k59_319625_2	395494.Galf_0151	1.66e-30	117.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2VKD2@28216|Betaproteobacteria,44V55@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
k59_1435674_1	1049564.TevJSym_ac01700	8.44e-55	187.0	COG5607@1|root,COG5607@2|Bacteria,1R5I1@1224|Proteobacteria,1S0QK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	pfam chad	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,His_Phos_1
k59_1375543_1	518637.EUBIFOR_02551	4.7e-43	157.0	COG0517@1|root,COG0517@2|Bacteria,1TQ4J@1239|Firmicutes	1239|Firmicutes	S	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_612659_1	1267005.KB911265_gene3640	9.74e-97	292.0	COG0577@1|root,COG0577@2|Bacteria,1MVSU@1224|Proteobacteria,2TUN8@28211|Alphaproteobacteria,3N7KA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_847800_1	768671.ThimaDRAFT_3309	5.4e-56	196.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1WW51@135613|Chromatiales	135613|Chromatiales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_436609_1	1408444.JHYC01000006_gene2410	6.72e-23	93.6	COG0589@1|root,COG0589@2|Bacteria,1RHE6@1224|Proteobacteria,1S9IV@1236|Gammaproteobacteria,1JE97@118969|Legionellales	118969|Legionellales	T	Universal stress protein	uspA	-	-	ko:K06149	-	-	-	-	ko00000	-	-	-	Usp
k59_436609_2	1049564.TevJSym_ao00360	9.29e-151	433.0	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,1RQ1Q@1236|Gammaproteobacteria,1J50Q@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	related to Ser Thr protein kinases	-	GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
k59_730378_1	1047013.AQSP01000139_gene2339	7.13e-40	139.0	COG2836@1|root,COG2836@2|Bacteria	2|Bacteria	K	Biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	DsbD_2
k59_730378_2	1297570.MESS4_140002	2.27e-11	64.7	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,43GX7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1330737_1	1397527.Q670_14855	4.61e-39	144.0	COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria,1XIQ4@135619|Oceanospirillales	135619|Oceanospirillales	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_274036_3	387093.SUN_0406	3.53e-48	162.0	COG4461@1|root,COG4461@2|Bacteria,1PFFH@1224|Proteobacteria,43ABM@68525|delta/epsilon subdivisions,2YR0C@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Lysozyme inhibitor LprI	-	-	-	-	-	-	-	-	-	-	-	-	LprI
k59_495375_1	706587.Desti_4807	8.2e-69	221.0	2C7GF@1|root,2Z7K0@2|Bacteria,1R4T5@1224|Proteobacteria,42NIE@68525|delta/epsilon subdivisions,2WJ3X@28221|Deltaproteobacteria,2MRY1@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	ko:K03293	-	-	-	-	ko00000	2.A.3.1	-	-	-
k59_319648_1	1159870.KB907784_gene2272	1.47e-73	233.0	COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2VHWS@28216|Betaproteobacteria,3T2FB@506|Alcaligenaceae	28216|Betaproteobacteria	C	Isocitrate lyase	aceA	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
k59_97658_1	1486424.A0A023W5Q6_9CAUD	3.23e-62	200.0	4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses  no RNA stage,4QPQ9@28883|Caudovirales	28883|Caudovirales	S	N-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1499595_2	395493.BegalDRAFT_3484	1.7e-11	64.3	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,45ZWD@72273|Thiotrichales	72273|Thiotrichales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_978553_1	105559.Nwat_2038	6.79e-101	310.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales	135613|Chromatiales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_847822_1	640511.BC1002_5476	9.12e-09	60.1	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2VKF3@28216|Betaproteobacteria,1K92Z@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
k59_1859035_1	1504672.669786460	9.48e-20	84.0	COG3094@1|root,COG3094@2|Bacteria,1MZN6@1224|Proteobacteria,2VUWN@28216|Betaproteobacteria,4AFZP@80864|Comamonadaceae	28216|Betaproteobacteria	S	Invasion gene expression up-regulator, SirB	sirB	-	-	-	-	-	-	-	-	-	-	-	SirB
k59_1859035_2	102125.Xen7305DRAFT_00017330	4.9e-06	55.5	COG4191@1|root,COG4191@2|Bacteria,1G1CF@1117|Cyanobacteria,3VNJ2@52604|Pleurocapsales	1117|Cyanobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,cNMP_binding
k59_319653_1	258594.RPA4391	1.95e-31	122.0	COG1409@1|root,COG1409@2|Bacteria,1MXD6@1224|Proteobacteria,2TSJ4@28211|Alphaproteobacteria,3JSN9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_1785662_1	188626.HMPREF0321_2176	9.57e-35	135.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria,1ZX0I@145357|Dermacoccaceae	201174|Actinobacteria	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1551484_1	1283283.ATXA01000009_gene3202	1.12e-22	97.4	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31,Ubie_methyltran
k59_391126_2	686340.Metal_0372	1.04e-178	530.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XEFJ@135618|Methylococcales	135618|Methylococcales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_978566_1	1123065.ATWL01000007_gene3252	1.15e-69	225.0	COG1904@1|root,COG1904@2|Bacteria,2I8PE@201174|Actinobacteria	201174|Actinobacteria	G	Isomerase	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
k59_1864577_2	96561.Dole_1202	9.54e-12	62.8	COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,42QR5@68525|delta/epsilon subdivisions,2WMSR@28221|Deltaproteobacteria,2MJFW@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lipocalin-like domain	-	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
k59_984081_1	1283300.ATXB01000001_gene811	9.29e-72	238.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1XEAI@135618|Methylococcales	135618|Methylococcales	L	DNA helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1864593_2	1313172.YM304_36490	9.1e-15	75.5	COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,2GKCA@201174|Actinobacteria	201174|Actinobacteria	O	Hydrolases of the alpha beta superfamily	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Hydrolase_4,OsmC
k59_278590_1	340099.Teth39_1666	4.61e-97	306.0	COG3968@1|root,COG3968@2|Bacteria,1UHUF@1239|Firmicutes,2481B@186801|Clostridia,42F1I@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Glutamine synthetase, catalytic	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
k59_147037_1	985867.AEWF01000004_gene199	2.86e-19	91.7	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2U2CU@28211|Alphaproteobacteria,47GQR@766|Rickettsiales	766|Rickettsiales	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_1673871_1	1112216.JH594425_gene3046	7.89e-15	74.7	COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2TSHG@28211|Alphaproteobacteria,2K1R5@204457|Sphingomonadales	204457|Sphingomonadales	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
k59_498701_1	981384.AEYW01000001_gene1562	1.49e-19	93.6	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,Response_reg,dCache_1
k59_1094669_1	1521187.JPIM01000124_gene3628	3.45e-63	216.0	COG0474@1|root,COG0474@2|Bacteria,2G5ZS@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_1864601_1	1229780.BN381_20028	1.22e-73	228.0	COG1309@1|root,COG1309@2|Bacteria,2GV75@201174|Actinobacteria,3UWIU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
k59_1336291_1	1120956.JHZK01000042_gene3051	1.91e-118	362.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,1JQ5T@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1022570_1	1317124.DW2_02440	4.96e-05	44.3	COG2010@1|root,COG2010@2|Bacteria,1RIV2@1224|Proteobacteria,2U9C5@28211|Alphaproteobacteria,2XN88@285107|Thioclava	28211|Alphaproteobacteria	C	Cytochrome c	soxX	-	-	ko:K17223	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
k59_1022570_2	1415756.JQMY01000001_gene2903	7.82e-66	203.0	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,2U72E@28211|Alphaproteobacteria,2PEDB@252301|Oceanicola	28211|Alphaproteobacteria	S	Sulfur oxidation protein SoxY	soxY	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY
k59_1554780_1	349124.Hhal_1396	1.9e-63	216.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales	135613|Chromatiales	D	DNA segregation ATPase FtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_396606_1	10224.XP_002736966.1	4.37e-24	103.0	KOG3105@1|root,KOG3105@2759|Eukaryota,38I47@33154|Opisthokonta,3BMCH@33208|Metazoa	33208|Metazoa	BD	DNA binding	POGK	-	-	-	-	-	-	-	-	-	-	-	BrkDBD,DDE_1,HTH_Tnp_Tc5,KRAB
k59_1438946_2	768671.ThimaDRAFT_2677	2.85e-72	223.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RMWT@1236|Gammaproteobacteria,1WW7N@135613|Chromatiales	135613|Chromatiales	K	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_925045_1	656024.FsymDg_2731	1.54e-10	65.9	COG0668@1|root,COG0668@2|Bacteria,2GJ51@201174|Actinobacteria,4EUQ6@85013|Frankiales	201174|Actinobacteria	M	mechanosensitive ion channel	mscS	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_925045_2	467200.ACFA01000249_gene5959	2.32e-31	117.0	COG2085@1|root,COG2085@2|Bacteria,2I8W4@201174|Actinobacteria	201174|Actinobacteria	S	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
k59_103093_1	1120949.KB903294_gene3949	4.27e-113	332.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,4DM3N@85008|Micromonosporales	201174|Actinobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_925052_1	1240349.ANGC01000031_gene3059	1.75e-63	216.0	COG2148@1|root,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria,4FXM0@85025|Nocardiaceae	201174|Actinobacteria	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
k59_1203863_1	1123354.AUDR01000015_gene279	8.59e-38	142.0	COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,2VHVC@28216|Betaproteobacteria,1KRFB@119069|Hydrogenophilales	119069|Hydrogenophilales	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	-	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
k59_498728_1	583355.Caka_2912	5.39e-94	288.0	COG3303@1|root,COG3303@2|Bacteria,46UP1@74201|Verrucomicrobia,3K7Z3@414999|Opitutae	414999|Opitutae	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C552
k59_1554808_1	870187.Thini_2085	1.95e-75	231.0	COG0431@1|root,COG0431@2|Bacteria,1RGV1@1224|Proteobacteria,1S2U5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Flavoprotein	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
k59_205652_1	367299.JOEE01000004_gene989	9.86e-39	129.0	COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria,4FHA9@85021|Intrasporangiaceae	201174|Actinobacteria	J	Binds the 23S rRNA	rpmE	GO:0008150,GO:0040007	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
k59_205652_2	1449355.JQNR01000005_gene4425	1.65e-48	166.0	COG0216@1|root,COG0216@2|Bacteria,2GJWG@201174|Actinobacteria	201174|Actinobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	GO:0008150,GO:0040007	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_1336357_1	545264.KB898745_gene1180	0.000623	42.7	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WW5M@135613|Chromatiales	135613|Chromatiales	EH	Anthranilate synthase component I	-	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_1336357_2	1121940.AUDZ01000016_gene132	2.22e-51	168.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1XH6R@135619|Oceanospirillales	135619|Oceanospirillales	EH	with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine	trpG	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_1438965_1	1045855.DSC_15485	9.56e-52	167.0	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria,1X643@135614|Xanthomonadales	135614|Xanthomonadales	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
k59_1438965_2	105559.Nwat_0033	2.12e-69	221.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1WXMZ@135613|Chromatiales	135613|Chromatiales	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_103139_1	717785.HYPMC_2577	2.98e-137	396.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2TQP8@28211|Alphaproteobacteria,3N6BR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_396664_1	1122176.KB903537_gene1626	4.25e-83	258.0	COG0446@1|root,COG0446@2|Bacteria,4NEK6@976|Bacteroidetes,1IWTF@117747|Sphingobacteriia	976|Bacteroidetes	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_925092_1	1033802.SSPSH_003480	2.64e-07	52.8	COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator	oxyR	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
k59_851042_1	314225.ELI_14900	1.84e-122	357.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2K2F6@204457|Sphingomonadales	204457|Sphingomonadales	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_1864682_1	382245.ASA_0173	2.23e-103	313.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria,1Y586@135624|Aeromonadales	135624|Aeromonadales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.113	ko:K12256	ko00330,ko01100,map00330,map01100	-	R08714	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_45662_1	948565.AFFP02000001_gene889	1.51e-76	243.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,1RMMB@1236|Gammaproteobacteria,1Y7MZ@135625|Pasteurellales	135625|Pasteurellales	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
k59_1731320_1	1123065.ATWL01000001_gene172	3.03e-98	293.0	COG0569@1|root,COG0569@2|Bacteria,2GK4N@201174|Actinobacteria	201174|Actinobacteria	P	PFAM TrkA-N domain protein	ceoB	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_1203888_1	880072.Desac_0689	4.41e-53	184.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2WIX5@28221|Deltaproteobacteria,2MQAA@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_278652_1	187272.Mlg_0484	2.2e-60	189.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,1S3QK@1236|Gammaproteobacteria,1WY9H@135613|Chromatiales	135613|Chromatiales	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
k59_1731326_1	404589.Anae109_3730	1.54e-44	159.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,438CB@68525|delta/epsilon subdivisions,2X3MN@28221|Deltaproteobacteria,2YWIY@29|Myxococcales	28221|Deltaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	-
k59_1613031_1	1385520.N802_15090	3.67e-29	110.0	COG0789@1|root,COG0789@2|Bacteria,2HBV6@201174|Actinobacteria,4FGAD@85021|Intrasporangiaceae	201174|Actinobacteria	K	MerR family	merR1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	MerR,MerR_1
k59_1613031_2	367299.JOEE01000008_gene562	1.32e-70	216.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4FH2P@85021|Intrasporangiaceae	201174|Actinobacteria	T	Signal peptide protein	garA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006110,GO:0006140,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010563,GO:0010675,GO:0010677,GO:0016020,GO:0016310,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0030312,GO:0030808,GO:0030809,GO:0030811,GO:0030812,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031330,GO:0036211,GO:0042325,GO:0042326,GO:0042802,GO:0043170,GO:0043412,GO:0043457,GO:0043467,GO:0043470,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045820,GO:0045912,GO:0045934,GO:0045936,GO:0045980,GO:0046777,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051193,GO:0051195,GO:0051196,GO:0051198,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1900371,GO:1900372,GO:1900542,GO:1900543,GO:1901564,GO:1903578,GO:1903579,GO:2001169,GO:2001170	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
k59_103170_1	997346.HMPREF9374_2408	5.32e-24	102.0	COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,4HC6W@91061|Bacilli,27BU6@186824|Thermoactinomycetaceae	91061|Bacilli	J	Putative RNA methylase family UPF0020	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
k59_278654_1	879212.DespoDRAFT_00919	1.51e-64	214.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,42NEZ@68525|delta/epsilon subdivisions,2WJ5R@28221|Deltaproteobacteria,2MHMS@213118|Desulfobacterales	28221|Deltaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_1864707_1	272943.RSP_3148	3.6e-27	102.0	COG2009@1|root,COG2009@2|Bacteria,1N8VA@1224|Proteobacteria,2UAYI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	succinate dehydrogenase	-	-	-	ko:K00247	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_1864707_2	391613.RTM1035_18630	4.17e-36	125.0	COG2142@1|root,COG2142@2|Bacteria,1MZKE@1224|Proteobacteria,2UDDU@28211|Alphaproteobacteria,46R1E@74030|Roseovarius	28211|Alphaproteobacteria	C	COG2142 Succinate dehydrogenase, hydrophobic anchor subunit	-	-	-	ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_1554835_1	713586.KB900536_gene55	5.64e-33	120.0	COG1286@1|root,COG1286@2|Bacteria,1N45N@1224|Proteobacteria,1SAE0@1236|Gammaproteobacteria,1X2FY@135613|Chromatiales	135613|Chromatiales	S	Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
k59_147100_1	765910.MARPU_03705	2.04e-178	516.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1WW0N@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1864710_1	298386.PBPRA2564	1.06e-12	69.7	COG4659@1|root,COG4659@2|Bacteria,1RDEP@1224|Proteobacteria,1RPAD@1236|Gammaproteobacteria,1XU3Z@135623|Vibrionales	135623|Vibrionales	C	Part of a membrane complex involved in electron transport	rnfG	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0055114	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
k59_1864710_2	1268239.PALB_4200	5.22e-62	203.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,2PZS8@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfD	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0044464,GO:0055114,GO:0071944	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
k59_205680_2	1236959.BAMT01000017_gene2374	2.43e-39	140.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2WEFP@28216|Betaproteobacteria,2KMIV@206350|Nitrosomonadales	206350|Nitrosomonadales	T	PFAM response regulator receiver	-	-	-	ko:K08083	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
k59_733975_1	335543.Sfum_4102	3.84e-98	295.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,42NF2@68525|delta/epsilon subdivisions,2WJ7Q@28221|Deltaproteobacteria,2MQE4@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_103182_1	979556.MTES_1506	2.55e-66	216.0	COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria,4FKQ1@85023|Microbacteriaceae	201174|Actinobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
k59_1613040_1	391038.Bphy_0371	3.05e-91	298.0	COG0247@1|root,COG0277@1|root,COG1146@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG1146@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,1K40G@119060|Burkholderiaceae	28216|Betaproteobacteria	C	FAD linked oxidase domain protein	glpCD	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_1269016_1	323261.Noc_0315	2.12e-65	208.0	COG0500@1|root,COG2226@2|Bacteria,1RDI3@1224|Proteobacteria,1S423@1236|Gammaproteobacteria,1WWQ9@135613|Chromatiales	135613|Chromatiales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
k59_675396_2	1219065.VPR01S_05_00660	8.36e-105	319.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,1RNJ9@1236|Gammaproteobacteria,1XSCR@135623|Vibrionales	135623|Vibrionales	E	COG0665 Glycine D-amino acid oxidases (deaminating)	-	-	-	ko:K09471	ko00330,ko01100,map00330,map01100	M00136	R07415	RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	DAO
k59_498771_1	575589.HMPREF0018_02640	3.3e-51	171.0	COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,1S5WA@1236|Gammaproteobacteria,3NJ0Z@468|Moraxellaceae	1236|Gammaproteobacteria	O	Thiol disulfide interchange protein	dsbA	-	-	ko:K03673	ko01503,map01503	M00728	-	-	ko00000,ko00001,ko00002,ko03110	-	-	-	DSBA
k59_147108_1	298655.KI912266_gene2790	3.44e-56	178.0	COG4334@1|root,COG4334@2|Bacteria,2IR4U@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2255)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2255
k59_147108_2	1120950.KB892742_gene3063	7.35e-32	120.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4DTWY@85009|Propionibacteriales	201174|Actinobacteria	C	Aldo/keto reductase family	yajO	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_147108_3	926564.KI911740_gene3404	2.04e-89	271.0	COG0667@1|root,COG0667@2|Bacteria,2GJ4R@201174|Actinobacteria,4F556@85017|Promicromonosporaceae	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
k59_1503409_1	519989.ECTPHS_07576	3.87e-47	164.0	COG1704@1|root,COG1704@2|Bacteria,1RDUH@1224|Proteobacteria,1S2KR@1236|Gammaproteobacteria,1WY4K@135613|Chromatiales	135613|Chromatiales	S	E3 Ubiquitin ligase	-	-	-	-	-	-	-	-	-	-	-	-	GIDE
k59_1094743_1	686340.Metal_2027	4.72e-30	112.0	COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,1SAHT@1236|Gammaproteobacteria,1XGEW@135618|Methylococcales	135618|Methylococcales	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_1094743_2	765912.Thimo_0946	1.72e-140	412.0	COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,1RMBX@1236|Gammaproteobacteria,1WXBG@135613|Chromatiales	135613|Chromatiales	F	PFAM Na dependent nucleoside transporter	-	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Gate,Nucleos_tra2_C,Nucleos_tra2_N
k59_498772_1	1255043.TVNIR_3160	3.35e-86	267.0	COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1WWZ8@135613|Chromatiales	135613|Chromatiales	S	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_1731348_1	1283287.KB822584_gene1336	7.78e-119	353.0	COG1171@1|root,COG1171@2|Bacteria,2GJAG@201174|Actinobacteria,4DN8T@85009|Propionibacteriales	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
k59_278680_1	1379270.AUXF01000003_gene3822	8.14e-23	102.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1ZSRY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_1613059_1	1123399.AQVE01000025_gene1967	1.41e-74	228.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,1S4E6@1236|Gammaproteobacteria,460MP@72273|Thiotrichales	72273|Thiotrichales	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
k59_675412_1	631362.Thi970DRAFT_00483	3.79e-19	82.0	COG2938@1|root,COG2938@2|Bacteria,1N7P4@1224|Proteobacteria,1SCKB@1236|Gammaproteobacteria,1WZ6Q@135613|Chromatiales	135613|Chromatiales	S	Flavinator of succinate dehydrogenase	-	-	-	ko:K09159	-	-	-	-	ko00000,ko02048	-	-	-	Sdh5
k59_926295_1	1121396.KB893035_gene3577	2.04e-72	226.0	COG0500@1|root,COG2226@2|Bacteria,1R3QX@1224|Proteobacteria,42PX7@68525|delta/epsilon subdivisions,2WKE5@28221|Deltaproteobacteria,2MHQZ@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_1504170_1	351607.Acel_1069	1.48e-11	63.2	COG0107@1|root,COG0107@2|Bacteria,2GIRP@201174|Actinobacteria,4ES76@85013|Frankiales	201174|Actinobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0008150,GO:0016740,GO:0016757,GO:0016763,GO:0040007	4.1.3.27	ko:K01657,ko:K02500	ko00340,ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00340,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023,M00026	R00985,R00986,R04558	RC00010,RC01190,RC01943,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_1379680_1	1348663.KCH_73650	1.98e-06	57.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,2M06T@2063|Kitasatospora	201174|Actinobacteria	EGP	Major Facilitator Superfamily	pqrB	-	-	ko:K08167	-	M00713,M00714	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.3	-	-	MFS_1
k59_1732030_1	1121405.dsmv_1731	9.51e-81	256.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2WJKC@28221|Deltaproteobacteria,2MJ79@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
k59_788324_1	1249627.D779_0210	8.4e-80	251.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1WVYW@135613|Chromatiales	135613|Chromatiales	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_926312_1	177437.HRM2_15150	1.06e-71	229.0	COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42PIE@68525|delta/epsilon subdivisions,2WM3C@28221|Deltaproteobacteria,2MMPY@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Polysulphide reductase, NrfD	moz	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
k59_1613737_1	1089545.KB913037_gene3915	8.54e-84	263.0	COG5421@1|root,COG5421@2|Bacteria,2GK2A@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_440768_1	398767.Glov_2723	6.54e-84	277.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1439748_1	1265313.HRUBRA_01494	2.48e-104	313.0	COG1597@1|root,COG1597@2|Bacteria,1RB97@1224|Proteobacteria,1S4B3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	lipid kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Mmp37
k59_788333_1	590998.Celf_2266	3.59e-37	135.0	COG0331@1|root,COG0331@2|Bacteria,2GME0@201174|Actinobacteria,4F0PZ@85016|Cellulomonadaceae	201174|Actinobacteria	I	Acyl transferase domain	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005835,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
k59_616649_1	985762.SAGN_03500	2.56e-22	102.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HB1B@91061|Bacilli,4GXKP@90964|Staphylococcaceae	91061|Bacilli	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,sCache_like
k59_676115_1	292415.Tbd_1072	1.33e-225	643.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2VS7B@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2
k59_926331_1	1123073.KB899245_gene183	9.93e-19	87.0	COG0515@1|root,COG0515@2|Bacteria,1QVRP@1224|Proteobacteria,1T2I6@1236|Gammaproteobacteria,1XCVF@135614|Xanthomonadales	135614|Xanthomonadales	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_1555551_1	63737.Npun_F2392	9.51e-78	253.0	COG3119@1|root,COG3119@2|Bacteria,1G3QV@1117|Cyanobacteria,1HJZV@1161|Nostocales	1117|Cyanobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_680021_1	713586.KB900536_gene1405	6.78e-12	66.6	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,1RNJW@1236|Gammaproteobacteria,1WZUW@135613|Chromatiales	135613|Chromatiales	Q	PFAM toluene tolerance	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
k59_680021_2	765912.Thimo_0132	3.18e-20	84.0	COG3118@1|root,COG3118@2|Bacteria,1RI6E@1224|Proteobacteria,1S8B4@1236|Gammaproteobacteria,1WYJW@135613|Chromatiales	135613|Chromatiales	O	Belongs to the thioredoxin family	-	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	Thioredoxin
k59_1274100_1	321846.PS417_23835	1.13e-13	69.3	COG1357@1|root,COG1357@2|Bacteria,1MZAT@1224|Proteobacteria,1S9V6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Pentapeptide	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
k59_1208272_1	1232683.ADIMK_0431	5.4e-137	400.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,465KZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iUTI89_1310.UTI89_C0772,iZ_1308.Z0993	Aminotran_3
k59_932214_1	247490.KSU1_C0703	1.99e-56	190.0	COG0845@1|root,COG0845@2|Bacteria,2IZDC@203682|Planctomycetes	203682|Planctomycetes	M	Biotin-lipoyl like	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1735795_1	1298863.AUEP01000003_gene3062	1.23e-48	171.0	COG1524@1|root,2Z9VM@2|Bacteria,2GWA2@201174|Actinobacteria,4DQ3R@85009|Propionibacteriales	201174|Actinobacteria	S	mannose-ethanolamine phosphotransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_403811_1	439235.Dalk_0683	1.22e-16	79.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42Q13@68525|delta/epsilon subdivisions,2WIT3@28221|Deltaproteobacteria,2MJ08@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM dihydropteroate synthase DHPS	-	-	2.1.1.258	ko:K15023	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R02289,R10243	RC00004,RC00113,RC01144,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
k59_403811_2	338963.Pcar_2033	5.15e-14	69.3	COG1611@1|root,COG1611@2|Bacteria,1RJ91@1224|Proteobacteria,42TR7@68525|delta/epsilon subdivisions,2WQUE@28221|Deltaproteobacteria,43VC6@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DNA_processg_A,Lysine_decarbox
k59_327444_1	1317124.DW2_04094	6.81e-22	99.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2TW3U@28211|Alphaproteobacteria,2XP3F@285107|Thioclava	28211|Alphaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_503135_2	313606.M23134_02244	8.12e-17	77.8	2AU0F@1|root,31JKB@2|Bacteria,4NHS6@976|Bacteroidetes,47Q5C@768503|Cytophagia	976|Bacteroidetes	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_284810_1	28072.Nos7524_1286	1.53e-30	129.0	COG2931@1|root,COG3210@1|root,COG3291@1|root,COG3595@1|root,COG4070@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG3595@2|Bacteria,COG4070@2|Bacteria,1GHDQ@1117|Cyanobacteria,1HUA0@1161|Nostocales	1117|Cyanobacteria	Q	Domain of unknown function (DUF4114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114
k59_1145164_1	377629.TERTU_4697	7.22e-94	289.0	COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,1RMAV@1236|Gammaproteobacteria,2PQ4J@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_1443526_1	376619.FTL_1511	9.03e-27	110.0	COG0584@1|root,COG0584@2|Bacteria,1MW6Z@1224|Proteobacteria,1SZRP@1236|Gammaproteobacteria,461I5@72273|Thiotrichales	72273|Thiotrichales	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_1208291_1	596151.DesfrDRAFT_1895	2.51e-52	182.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MEP8@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7,Pyr_redox_2
k59_932235_2	1049564.TevJSym_an00340	2.45e-68	210.0	2DX2X@1|root,32V2M@2|Bacteria,1MZZC@1224|Proteobacteria,1S4WN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_52077_1	765914.ThisiDRAFT_0107	5.98e-28	112.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1WXKA@135613|Chromatiales	135613|Chromatiales	G	PFAM Alpha amylase, catalytic	-	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_991427_1	472759.Nhal_1117	2.05e-46	155.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,1SCZX@1236|Gammaproteobacteria,1WZ3C@135613|Chromatiales	135613|Chromatiales	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
k59_991427_2	765913.ThidrDRAFT_2617	2.55e-19	83.6	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,1S5WH@1236|Gammaproteobacteria,1WYNA@135613|Chromatiales	135613|Chromatiales	S	Belongs to the CinA family	-	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
k59_1508495_1	1123070.KB899257_gene2274	6.59e-19	86.3	COG3119@1|root,COG3119@2|Bacteria,46TR4@74201|Verrucomicrobia,2IV34@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_210199_1	717785.HYPMC_4689	1.55e-102	303.0	COG0335@1|root,COG3743@1|root,COG0335@2|Bacteria,COG3743@2|Bacteria,1RH3A@1224|Proteobacteria,2U9DF@28211|Alphaproteobacteria,3N6WT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
k59_561743_1	330214.NIDE4063	7.7e-65	210.0	COG1748@1|root,COG1748@2|Bacteria	2|Bacteria	E	saccharopine dehydrogenase activity	lysDH	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP
k59_1443533_1	572477.Alvin_1910	5.47e-80	268.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1WWWW@135613|Chromatiales	135613|Chromatiales	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
k59_1443533_2	1123354.AUDR01000012_gene1918	1.11e-30	112.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,2VUC8@28216|Betaproteobacteria,1KRTC@119069|Hydrogenophilales	119069|Hydrogenophilales	P	CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
k59_403852_1	1298863.AUEP01000001_gene985	1.4e-98	311.0	COG1251@1|root,COG1251@2|Bacteria,2GJ3U@201174|Actinobacteria,4DNQ5@85009|Propionibacteriales	201174|Actinobacteria	C	Nitrite reductase NAD(P)H , large subunit	nirB	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
k59_1678508_1	631362.Thi970DRAFT_03706	7.16e-104	312.0	COG2230@1|root,COG2230@2|Bacteria,1MUW5@1224|Proteobacteria,1RPUC@1236|Gammaproteobacteria,1WWIX@135613|Chromatiales	135613|Chromatiales	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_110330_1	876269.ARWA01000001_gene849	2.65e-30	117.0	COG1309@1|root,COG1309@2|Bacteria,1QE3S@1224|Proteobacteria,2U3XG@28211|Alphaproteobacteria,3NA02@45404|Beijerinckiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1559500_1	868131.MSWAN_0067	2.13e-23	103.0	COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,23PEI@183925|Methanobacteria	183925|Methanobacteria	P	ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase
k59_1026379_1	742742.HMPREF9452_01692	6e-72	227.0	COG1294@1|root,COG1294@2|Bacteria,2GMFV@201174|Actinobacteria,4CUH3@84998|Coriobacteriia	84998|Coriobacteriia	C	Cytochrome bd terminal oxidase subunit II	-	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
k59_1145206_1	1049564.TevJSym_at00030	4.69e-36	134.0	28I2K@1|root,2Z86N@2|Bacteria,1R1GA@1224|Proteobacteria,1RRPU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_932294_1	342610.Patl_1061	1.51e-51	182.0	COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1RMSA@1236|Gammaproteobacteria,2Q0Z2@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	U	COG0811 Biopolymer transport proteins	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_1508533_1	366394.Smed_5768	5.86e-109	328.0	COG3119@1|root,COG3119@2|Bacteria,1MV4J@1224|Proteobacteria,2TT2I@28211|Alphaproteobacteria,4BCGZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	C-terminal region of aryl-sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_1792470_1	472759.Nhal_2115	4.32e-56	181.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1WYRM@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_284877_1	335543.Sfum_2496	3.03e-85	259.0	COG2834@1|root,COG2834@2|Bacteria,1R5U8@1224|Proteobacteria,42MIS@68525|delta/epsilon subdivisions,2WMK7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
k59_1559524_1	1117315.AHCA01000010_gene910	4.59e-16	79.7	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,2PZU4@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	Belongs to the peptidase S41A family	prc	GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	BAGE,DUF3340,PDZ,Peptidase_S41
k59_561784_1	768671.ThimaDRAFT_0819	4.77e-53	175.0	COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,1RREE@1236|Gammaproteobacteria,1WWMU@135613|Chromatiales	135613|Chromatiales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_791435_1	522306.CAP2UW1_1243	5.44e-99	321.0	COG0022@1|root,COG0332@1|root,COG0508@1|root,COG1071@1|root,COG0022@2|Bacteria,COG0332@2|Bacteria,COG0508@2|Bacteria,COG1071@2|Bacteria,1MU9N@1224|Proteobacteria,2VI2A@28216|Betaproteobacteria,1KPNJ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH_1	-	1.2.4.4,2.3.1.180	ko:K00648,ko:K11381	ko00061,ko00280,ko00640,ko01100,ko01110,ko01130,ko01212,map00061,map00280,map00640,map01100,map01110,map01130,map01212	M00036,M00082,M00083	R07599,R07600,R07601,R07602,R07603,R07604,R10707,R10996,R10997	RC00004,RC00027,RC00627,RC02729,RC02743,RC02883,RC02888,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_405108_1	671143.DAMO_3066	1.53e-65	218.0	COG0318@1|root,COG0318@2|Bacteria,2NQWW@2323|unclassified Bacteria	2|Bacteria	IQ	AMP-binding enzyme	JD73_00810	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C_2
k59_286058_1	1265505.ATUG01000002_gene2635	2.06e-53	180.0	COG1058@1|root,COG1058@2|Bacteria,1R1WS@1224|Proteobacteria,43DBS@68525|delta/epsilon subdivisions,2X8HS@28221|Deltaproteobacteria,2MPNP@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
k59_1209074_1	404589.Anae109_1606	3.33e-37	142.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,437ZU@68525|delta/epsilon subdivisions,2X39R@28221|Deltaproteobacteria,2YV0T@29|Myxococcales	28221|Deltaproteobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_1873168_1	472759.Nhal_0221	7.51e-81	249.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1WXP3@135613|Chromatiales	135613|Chromatiales	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_1384548_1	1415779.JOMH01000001_gene3148	8.05e-55	190.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1X3KG@135614|Xanthomonadales	135614|Xanthomonadales	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_405118_2	572477.Alvin_1133	2.5e-171	491.0	COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,1RPM0@1236|Gammaproteobacteria,1WWJT@135613|Chromatiales	135613|Chromatiales	H	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
k59_856346_1	582899.Hden_2570	9.26e-43	154.0	COG5434@1|root,COG5434@2|Bacteria,1N3IG@1224|Proteobacteria,2U0A8@28211|Alphaproteobacteria,3N9IQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Periplasmic copper-binding protein (NosD)	MA20_15840	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Pectate_lyase_3
k59_856346_2	1336208.JADY01000018_gene3234	4.28e-18	84.3	COG4448@1|root,COG4448@2|Bacteria,1R4NH@1224|Proteobacteria,2TV9J@28211|Alphaproteobacteria,2JQI6@204441|Rhodospirillales	204441|Rhodospirillales	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
k59_992694_1	1042377.AFPJ01000032_gene2743	1.97e-91	298.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RS1Q@1236|Gammaproteobacteria,469PS@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1618555_1	1049564.TevJSym_cv00020	1.37e-137	400.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,1RQ01@1236|Gammaproteobacteria,1J4TK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	norB	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0016966,GO:0055114	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
k59_1793187_1	572477.Alvin_2869	1.68e-70	228.0	28MU5@1|root,2ZB23@2|Bacteria,1R58G@1224|Proteobacteria,1RP0E@1236|Gammaproteobacteria,1WVUZ@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_111602_1	266940.Krad_1453	1.17e-20	94.0	COG1512@1|root,COG1512@2|Bacteria,2GMGW@201174|Actinobacteria	201174|Actinobacteria	M	TPM domain	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	TPM_phosphatase
k59_1444311_1	590998.Celf_2499	4.49e-101	318.0	COG3858@1|root,COG5479@1|root,COG3858@2|Bacteria,COG5479@2|Bacteria,2HYIN@201174|Actinobacteria	201174|Actinobacteria	M	hydrolase, family 25	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,LGFP
k59_504037_1	1304275.C41B8_10400	3.38e-70	233.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378	DALR_1,tRNA_synt_2f
k59_562603_1	1123399.AQVE01000016_gene2770	1.8e-16	78.6	28KIA@1|root,2ZA3I@2|Bacteria,1MXIF@1224|Proteobacteria,1RMA6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	dsrS	-	-	-	-	-	-	-	-	-	-	-	-
k59_562603_2	1255043.TVNIR_2718	3.45e-16	77.8	COG0790@1|root,COG0790@2|Bacteria,1PFSC@1224|Proteobacteria,1TJ65@1236|Gammaproteobacteria,1WY15@135613|Chromatiales	135613|Chromatiales	S	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
k59_856356_1	593907.Celgi_1860	2.35e-79	249.0	COG0628@1|root,COG0628@2|Bacteria,2GK0H@201174|Actinobacteria,4F20T@85016|Cellulomonadaceae	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1344969_1	1122132.AQYH01000007_gene2087	2.94e-11	62.4	COG3824@1|root,COG3824@2|Bacteria,1N18M@1224|Proteobacteria,2UBUK@28211|Alphaproteobacteria,4BMY4@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Zincin-like metallopeptidase	MA20_43655	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Zincin_1
k59_933521_1	266117.Rxyl_0056	4.01e-105	312.0	COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria,4CPC1@84995|Rubrobacteria	84995|Rubrobacteria	S	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
k59_562605_2	1123393.KB891332_gene2715	5.2e-75	236.0	2EFRD@1|root,339HE@2|Bacteria,1NDZX@1224|Proteobacteria,2WDJX@28216|Betaproteobacteria,1KSY3@119069|Hydrogenophilales	119069|Hydrogenophilales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1873200_2	1166016.W5S_2759	1.14e-12	72.0	COG0664@1|root,COG0664@2|Bacteria,1RFEJ@1224|Proteobacteria,1SYK9@1236|Gammaproteobacteria,1MQ2U@122277|Pectobacterium	1236|Gammaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_1618562_1	335543.Sfum_1991	3.45e-60	204.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MQU1@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
k59_286100_1	935839.JAGJ01000002_gene848	4.94e-73	228.0	COG1216@1|root,COG1216@2|Bacteria,2GMQQ@201174|Actinobacteria,4F5WB@85017|Promicromonosporaceae	201174|Actinobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
k59_792102_1	251221.35211561	1.37e-09	58.9	COG0058@1|root,COG0058@2|Bacteria,1FZUX@1117|Cyanobacteria	1117|Cyanobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_792102_2	1123399.AQVE01000019_gene1610	3.77e-21	89.4	COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,1RN27@1236|Gammaproteobacteria,460KK@72273|Thiotrichales	72273|Thiotrichales	P	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_211087_1	935866.JAER01000025_gene2997	1.58e-78	244.0	COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria,4DTR6@85009|Propionibacteriales	201174|Actinobacteria	E	Semialdehyde dehydrogenase, NAD binding domain	asd	GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3708c	Semialdhyde_dh,Semialdhyde_dhC
k59_1509486_1	929556.Solca_3818	2.59e-23	104.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IR3J@117747|Sphingobacteriia	976|Bacteroidetes	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,HTH_18,TPR_16,TPR_2,TPR_8
k59_1344982_1	1049564.TevJSym_ad00410	5.23e-41	139.0	2E8HY@1|root,332W0@2|Bacteria,1N9SS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1344982_2	1460635.JCM19038_4119	9.62e-07	48.5	COG0432@1|root,COG0432@2|Bacteria,1V6J7@1239|Firmicutes,4HI2R@91061|Bacilli	91061|Bacilli	S	Uncharacterised protein family UPF0047	yugU	-	-	-	-	-	-	-	-	-	-	-	UPF0047
k59_1793200_1	1144275.COCOR_01450	3.42e-172	503.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria	1224|Proteobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
k59_1275182_1	1485545.JQLW01000006_gene295	1.31e-11	65.9	COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria	1224|Proteobacteria	T	PFAM Forkhead-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
k59_621268_1	335543.Sfum_2709	6.05e-132	393.0	COG0642@1|root,COG2205@2|Bacteria,1QHXX@1224|Proteobacteria,42NW1@68525|delta/epsilon subdivisions,2WJUF@28221|Deltaproteobacteria,2MR85@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_53286_1	1125863.JAFN01000001_gene3442	3.44e-50	169.0	COG4177@1|root,COG4177@2|Bacteria,1PTVX@1224|Proteobacteria,42Q12@68525|delta/epsilon subdivisions,2WKBF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_53286_2	1125863.JAFN01000001_gene3443	4.56e-66	209.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42NUE@68525|delta/epsilon subdivisions,2WMSB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_111638_1	208439.AJAP_30725	2.8e-75	227.0	COG0346@1|root,COG0346@2|Bacteria,2IFMD@201174|Actinobacteria,4E2W4@85010|Pseudonocardiales	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_562621_1	479434.Sthe_1601	1.01e-36	136.0	COG1624@1|root,COG1624@2|Bacteria,2G6J7@200795|Chloroflexi,27XJ7@189775|Thermomicrobia	189775|Thermomicrobia	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	-	-	-	-	-	-	-	-	-	-	DisA_N
k59_1509493_1	583355.Caka_0208	2.82e-51	176.0	COG1663@1|root,COG1663@2|Bacteria,46SBI@74201|Verrucomicrobia,3K7KP@414999|Opitutae	414999|Opitutae	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
k59_328398_1	1121362.A605_09440	1.34e-40	143.0	COG1496@1|root,COG1496@2|Bacteria,2GN1M@201174|Actinobacteria,22JJQ@1653|Corynebacteriaceae	201174|Actinobacteria	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
k59_933544_1	522306.CAP2UW1_3313	6.33e-78	243.0	COG1376@1|root,COG1376@2|Bacteria,1Q823@1224|Proteobacteria,2VRBW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_111644_1	472759.Nhal_0357	5.06e-101	304.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1WXUS@135613|Chromatiales	1236|Gammaproteobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_445455_1	497964.CfE428DRAFT_3932	6.89e-15	75.9	COG1530@1|root,COG1530@2|Bacteria,46S5S@74201|Verrucomicrobia	74201|Verrucomicrobia	J	TIGRFAM ribonuclease, Rne Rng family	cafA	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
k59_445455_2	632245.CLP_3106	1.37e-11	65.1	COG2017@1|root,COG2017@2|Bacteria,1TQGJ@1239|Firmicutes,249DZ@186801|Clostridia,36F59@31979|Clostridiaceae	186801|Clostridia	G	Converts alpha-aldose to the beta-anomer	mro	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
k59_152695_1	768671.ThimaDRAFT_2224	6.29e-152	436.0	COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,1RUI0@1236|Gammaproteobacteria,1WXI7@135613|Chromatiales	135613|Chromatiales	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
k59_448605_1	367299.JOEE01000002_gene2285	2.89e-74	236.0	COG2211@1|root,COG2211@2|Bacteria,2HD4Y@201174|Actinobacteria,4FFB2@85021|Intrasporangiaceae	201174|Actinobacteria	G	transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
k59_684195_1	345341.KUTG_03543	6.64e-132	385.0	COG1621@1|root,COG1621@2|Bacteria,2H3S0@201174|Actinobacteria,4EA5E@85010|Pseudonocardiales	201174|Actinobacteria	G	Glycosyl hydrolases family 32 N-terminal domain	-	-	3.2.1.26	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R00802,R02410,R03635,R03921,R06088	RC00028,RC00077	ko00000,ko00001,ko01000	-	GH32	-	Glyco_hydro_32N
k59_290196_1	243233.MCA1545	9.17e-138	424.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1XE0B@135618|Methylococcales	135618|Methylococcales	H	Vitamin B12 dependent methionine synthase, activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_859266_1	926569.ANT_16680	3.91e-61	208.0	COG0317@1|root,COG0317@2|Bacteria,2G67Y@200795|Chloroflexi	200795|Chloroflexi	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_937943_1	367299.JOEE01000010_gene3338	2.35e-91	269.0	COG1225@1|root,COG1225@2|Bacteria,2GKME@201174|Actinobacteria,4FGWJ@85021|Intrasporangiaceae	201174|Actinobacteria	O	Peroxiredoxin	ahpE	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
k59_937943_2	367299.JOEE01000010_gene3337	1.06e-05	46.6	COG0327@1|root,COG0327@2|Bacteria,2GKHZ@201174|Actinobacteria,4FFKW@85021|Intrasporangiaceae	201174|Actinobacteria	S	NIF3 (NGG1p interacting factor 3)	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	NIF3
k59_1104170_2	1132855.KB913035_gene2230	1.9e-30	115.0	COG1234@1|root,COG1234@2|Bacteria,1QU4B@1224|Proteobacteria,2VH0D@28216|Betaproteobacteria,2KMHV@206350|Nitrosomonadales	206350|Nitrosomonadales	S	cAMP phosphodiesterases class-II	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_448614_1	420324.KI912026_gene4783	1.78e-10	65.5	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2TR81@28211|Alphaproteobacteria,1JTCT@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_1031218_1	1232437.KL661966_gene3173	4.11e-24	107.0	COG2133@1|root,COG2133@2|Bacteria,1NRFC@1224|Proteobacteria,42YAV@68525|delta/epsilon subdivisions,2WTUF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1104174_1	1045855.DSC_00630	3.54e-52	184.0	COG1111@1|root,COG1205@1|root,COG1111@2|Bacteria,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,1S0XD@1236|Gammaproteobacteria,1X3W6@135614|Xanthomonadales	135614|Xanthomonadales	L	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
k59_1349660_1	1230338.MOMA_03380	6.36e-15	70.1	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,1S452@1236|Gammaproteobacteria,3NN47@468|Moraxellaceae	1236|Gammaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010608,GO:0015935,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031329,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043487,GO:0043488,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903311,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
k59_1349660_2	28229.ND2E_0138	1.66e-49	163.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,1S1Z1@1236|Gammaproteobacteria,2Q61D@267889|Colwelliaceae	1236|Gammaproteobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_57572_1	1182590.BN5_02655	2.35e-32	131.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1YI42@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Soluble lytic murein transglycosylase L domain	slt	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009274,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	iETEC_1333.ETEC_4747,iPC815.YPO0452	SLT,SLT_L
k59_794623_1	768671.ThimaDRAFT_2410	2.67e-105	308.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1WXDV@135613|Chromatiales	135613|Chromatiales	K	response regulator receiver	-	-	-	ko:K13041	ko02020,map02020	M00514	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_1563353_1	1713.JOFV01000002_gene705	6.61e-54	182.0	COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria,4F2FU@85016|Cellulomonadaceae	201174|Actinobacteria	GM	ATPases associated with a variety of cellular activities	-	-	3.6.3.40	ko:K01990,ko:K09693	ko02010,map02010	M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.104	-	-	ABC_tran,Wzt_C
k59_1149659_1	1265505.ATUG01000002_gene1002	1.07e-71	227.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,42M3V@68525|delta/epsilon subdivisions,2WJJ4@28221|Deltaproteobacteria,2MHT5@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_1796844_1	1121405.dsmv_1651	3.18e-75	233.0	COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,42U06@68525|delta/epsilon subdivisions,2X1ZC@28221|Deltaproteobacteria,2MNUZ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1796848_1	935557.ATYB01000014_gene1947	4.73e-35	135.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TT6V@28211|Alphaproteobacteria,4BA39@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Chloride channel protein	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
k59_1796848_2	243233.MCA0021	2.14e-49	165.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1XDSQ@135618|Methylococcales	135618|Methylococcales	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
k59_215157_1	395493.BegalDRAFT_3457	5.41e-10	60.1	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,45ZYD@72273|Thiotrichales	72273|Thiotrichales	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
k59_215157_2	1236542.BALM01000021_gene1603	9.44e-10	62.8	COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria,2Q9DH@267890|Shewanellaceae	1236|Gammaproteobacteria	NU	TIGRFAM type IV pilus biogenesis stability protein PilW	pilF	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	LysM,TPR_12,TPR_16,TPR_17,TPR_19,TPR_2,TPR_8
k59_1105278_1	471853.Bcav_1207	5.44e-65	224.0	COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_1683296_1	314278.NB231_16933	2.63e-13	68.2	COG2930@1|root,COG2930@2|Bacteria,1RCYH@1224|Proteobacteria,1S41U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Las17-binding protein actin regulator	CT2216	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_1683296_2	1042375.AFPL01000025_gene1196	3e-56	196.0	COG2206@1|root,COG3437@1|root,COG4252@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,COG4252@2|Bacteria,1MV37@1224|Proteobacteria,1RM9C@1236|Gammaproteobacteria,465R9@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD_5
k59_860245_1	290398.Csal_1278	1.06e-109	329.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1XHR4@135619|Oceanospirillales	135619|Oceanospirillales	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_1622446_1	425104.Ssed_3607	3.32e-51	166.0	2B6UZ@1|root,31ZUH@2|Bacteria,1QDF2@1224|Proteobacteria,1T9DM@1236|Gammaproteobacteria,2QC2Z@267890|Shewanellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1513893_1	156889.Mmc1_2107	3.96e-63	209.0	COG0348@1|root,COG1152@1|root,COG0348@2|Bacteria,COG1152@2|Bacteria,1MY5M@1224|Proteobacteria,2TR0X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CK	COG3901 Regulator of nitric oxide reductase transcription	nosR	-	-	ko:K19339,ko:K19343	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind,Fer4_5
k59_291780_1	367299.JOEE01000004_gene1162	9.64e-119	352.0	COG0004@1|root,COG0004@2|Bacteria,2GIZK@201174|Actinobacteria,4FE69@85021|Intrasporangiaceae	201174|Actinobacteria	P	Ammonium Transporter	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_566884_2	1304885.AUEY01000010_gene1670	6.65e-20	85.9	COG2050@1|root,COG2050@2|Bacteria,1N61W@1224|Proteobacteria,42U4S@68525|delta/epsilon subdivisions,2WQWD@28221|Deltaproteobacteria,2MKZU@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_1032342_1	768671.ThimaDRAFT_2242	4.42e-78	241.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1WWQ1@135613|Chromatiales	135613|Chromatiales	H	Belongs to the ribF family	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
k59_291795_1	1500894.JQNN01000001_gene1234	4.04e-84	263.0	COG0280@1|root,COG0280@2|Bacteria,1QTXP@1224|Proteobacteria,2VJ4B@28216|Betaproteobacteria,473C2@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Phosphate acetyl/butaryl transferase	-	-	2.3.1.19,2.3.1.8	ko:K00625,ko:K00634	ko00430,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921,R01174	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas,PTA_PTB
k59_1032347_1	1454004.AW11_02751	1.38e-88	275.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,2VH7G@28216|Betaproteobacteria	28216|Betaproteobacteria	M	PFAM secretion protein HlyD family protein	-	-	-	ko:K01993,ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_291809_1	519989.ECTPHS_01999	7.04e-81	259.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1WWS1@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_449642_1	335543.Sfum_0075	1.15e-61	205.0	COG1355@1|root,COG1355@2|Bacteria,1N5H1@1224|Proteobacteria,42TIN@68525|delta/epsilon subdivisions,2WR24@28221|Deltaproteobacteria,2MQK2@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
k59_1105321_1	1122212.AULO01000006_gene1832	1.18e-31	117.0	COG0847@1|root,COG0847@2|Bacteria,1P0GY@1224|Proteobacteria,1S6UR@1236|Gammaproteobacteria,1XJU3@135619|Oceanospirillales	135619|Oceanospirillales	L	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_1105321_2	357804.Ping_1534	1.92e-29	114.0	COG0590@1|root,COG0590@2|Bacteria,1N1ZH@1224|Proteobacteria,1S94B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	FJ	Cytidine and deoxycytidylate deaminase zinc-binding region	-	-	-	-	-	-	-	-	-	-	-	-	dCMP_cyt_deam_1
k59_1622476_1	279238.Saro_1115	3.35e-26	100.0	COG0633@1|root,COG0633@2|Bacteria,1N261@1224|Proteobacteria,2UC7B@28211|Alphaproteobacteria,2K5DE@204457|Sphingomonadales	204457|Sphingomonadales	C	ferredoxin	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
k59_1622476_2	2074.JNYD01000006_gene1875	6.42e-25	106.0	COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria,4EA3F@85010|Pseudonocardiales	201174|Actinobacteria	I	SnoaL-like domain	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1,SnoaL_2
k59_1513934_1	1131269.AQVV01000011_gene2489	7.61e-30	112.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	hflC	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_685187_1	937777.Deipe_2795	1.36e-46	166.0	COG0438@1|root,COG0438@2|Bacteria,1WJTX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_332806_1	1131269.AQVV01000020_gene2195	4.97e-80	246.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	appC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_332806_2	986075.CathTA2_2610	1.28e-39	142.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,4HA4E@91061|Bacilli	91061|Bacilli	P	Belongs to the ABC transporter superfamily	appD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1513947_1	472759.Nhal_2213	5.74e-50	179.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1WVV2@135613|Chromatiales	135613|Chromatiales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_685192_1	644966.Tmar_0392	5.88e-31	123.0	COG3547@1|root,COG3547@2|Bacteria,1V0B6@1239|Firmicutes,248VY@186801|Clostridia	186801|Clostridia	L	Transposase IS116 IS110 IS902	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_156979_1	1122132.AQYH01000003_gene3156	3.06e-91	285.0	COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2TR9C@28211|Alphaproteobacteria,4B93R@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC-type amino acid transport system, permease component	aapM	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09971	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
k59_1032385_1	1123024.AUII01000011_gene4401	8.9e-62	206.0	COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria,4EAVH@85010|Pseudonocardiales	201174|Actinobacteria	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_1448362_1	1123392.AQWL01000004_gene2635	3.05e-82	251.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2VKQ0@28216|Betaproteobacteria,1KSCI@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Transketolase, pyrimidine binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Transket_pyr,Transketolase_C
k59_1448362_2	243159.AFE_3070	1.89e-21	93.2	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,1RWHU@1236|Gammaproteobacteria,2NC06@225057|Acidithiobacillales	225057|Acidithiobacillales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_743882_1	1232437.KL661999_gene4698	2.3e-37	134.0	COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,42Q6C@68525|delta/epsilon subdivisions,2WMD6@28221|Deltaproteobacteria,2MHY6@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_743882_2	177437.HRM2_38680	1.76e-26	103.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,42R4B@68525|delta/epsilon subdivisions,2WMZN@28221|Deltaproteobacteria,2MHNA@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_1564331_1	713586.KB900536_gene1078	1.03e-16	84.0	COG3249@1|root,COG3249@2|Bacteria,1N0PD@1224|Proteobacteria,1S9C4@1236|Gammaproteobacteria,1X0ZE@135613|Chromatiales	135613|Chromatiales	S	Uncharacterized protein conserved in bacteria (DUF2066)	-	-	-	ko:K09938	-	-	-	-	ko00000	-	-	-	DUF2066
k59_1279797_1	1082933.MEA186_30911	2.92e-52	191.0	COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2U1YP@28211|Alphaproteobacteria,43JUP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,HemolysinCabind,P_proprotein,VWA_2
k59_743897_1	994479.GL877883_gene7356	6.17e-05	47.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria,4DXFT@85010|Pseudonocardiales	201174|Actinobacteria	M	amidohydrolase	amiA	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_1683379_1	768671.ThimaDRAFT_0847	8.56e-67	223.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1SA31@1236|Gammaproteobacteria	1224|Proteobacteria	T	SMART ATP-binding region, ATPase-like	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3
k59_508403_1	1231391.AMZF01000063_gene1104	1.17e-58	200.0	COG4819@1|root,COG4819@2|Bacteria,1PPGT@1224|Proteobacteria	1224|Proteobacteria	E	ethanolamine utilization protein	eutA	GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0030091,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009,GO:0071704,GO:1901564	-	ko:K04019	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001	-	-	-	EutA
k59_860337_1	637389.Acaty_c0306	1.08e-34	134.0	COG0508@1|root,COG1249@1|root,COG0508@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,2NBVW@225057|Acidithiobacillales	225057|Acidithiobacillales	C	e3 binding domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding,Pyr_redox_2,Pyr_redox_dim
k59_860337_2	743299.Acife_3081	1.42e-18	83.6	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,2NCNM@225057|Acidithiobacillales	225057|Acidithiobacillales	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_157004_2	760192.Halhy_1114	1.93e-80	252.0	COG5520@1|root,COG5520@2|Bacteria,4NF4C@976|Bacteroidetes,1INPD@117747|Sphingobacteriia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 30 family	-	-	3.2.1.45	ko:K01201	ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH30	-	Glyco_hydro_30,Glyco_hydro_30C
k59_1388587_1	443152.MDG893_08200	3.58e-88	270.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,464DG@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475	TGT
k59_291926_2	387093.SUN_2171	3.35e-30	114.0	COG4314@1|root,COG4314@2|Bacteria,1N3G0@1224|Proteobacteria,42U9E@68525|delta/epsilon subdivisions,2YQ2V@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	lipoprotein involved in nitrous oxide reduction	-	-	-	ko:K19342	-	-	-	-	ko00000	-	-	-	NosL
k59_860352_1	857087.Metme_1354	8.39e-45	165.0	COG3072@1|root,COG3072@2|Bacteria,1PI5T@1224|Proteobacteria,1RMPZ@1236|Gammaproteobacteria,1XDJQ@135618|Methylococcales	135618|Methylococcales	F	PFAM Adenylate cyclase, class-I	-	-	4.6.1.1	ko:K05851	ko00230,ko02026,ko05111,map00230,map02026,map05111	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	Adenyl_cycl_N,Adenylate_cycl
k59_1683401_1	1279017.AQYJ01000029_gene3707	2.18e-36	129.0	COG3749@1|root,COG3749@2|Bacteria,1RJR9@1224|Proteobacteria,1S64S@1236|Gammaproteobacteria,46803@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF934
k59_1683401_2	1499686.BN1079_00746	1.22e-50	174.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,1RMFH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate	cysI	-	1.8.1.2	ko:K00381	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_508434_1	1248916.ANFY01000003_gene583	6.96e-51	178.0	COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2TVJ5@28211|Alphaproteobacteria,2K04D@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase, M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_1796956_2	765912.Thimo_0132	3.09e-41	140.0	COG3118@1|root,COG3118@2|Bacteria,1RI6E@1224|Proteobacteria,1S8B4@1236|Gammaproteobacteria,1WYJW@135613|Chromatiales	135613|Chromatiales	O	Belongs to the thioredoxin family	-	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	Thioredoxin
k59_291956_1	1178482.BJB45_10705	2.18e-08	60.1	COG1426@1|root,COG1426@2|Bacteria,1N240@1224|Proteobacteria,1RQMV@1236|Gammaproteobacteria,1XM0P@135619|Oceanospirillales	135619|Oceanospirillales	S	protein conserved in bacteria	-	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
k59_685251_1	1121405.dsmv_0379	1.75e-55	189.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,42N93@68525|delta/epsilon subdivisions,2WJ9N@28221|Deltaproteobacteria,2MHX8@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,TrkA_C,Voltage_CLC
k59_1514028_1	105559.Nwat_0843	1.82e-43	152.0	COG5361@1|root,COG5361@2|Bacteria,1NBVB@1224|Proteobacteria,1SES6@1236|Gammaproteobacteria,1X1NF@135613|Chromatiales	135613|Chromatiales	S	Neurotransmitter-gated ion-channel ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Neur_chan_LBD
k59_685253_1	857087.Metme_3765	4.07e-114	345.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1XE1C@135618|Methylococcales	135618|Methylococcales	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_449744_1	187272.Mlg_0413	4.16e-89	275.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1WWPA@135613|Chromatiales	135613|Chromatiales	S	modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_1448428_1	471853.Bcav_1573	1.94e-148	429.0	COG0065@1|root,COG0065@2|Bacteria,2GKT7@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_332883_1	1127673.GLIP_0832	2.77e-73	229.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,1RMK2@1236|Gammaproteobacteria,464DE@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_743944_2	314225.ELI_02275	5.71e-06	52.0	COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,2TTJ5@28211|Alphaproteobacteria,2K3CU@204457|Sphingomonadales	204457|Sphingomonadales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_795487_1	590998.Celf_1874	1.09e-79	246.0	COG0109@1|root,COG0109@2|Bacteria,2GJMY@201174|Actinobacteria,4F11Z@85016|Cellulomonadaceae	201174|Actinobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_1105444_1	593907.Celgi_3101	6.98e-78	249.0	COG0373@1|root,COG0373@2|Bacteria,2GJRA@201174|Actinobacteria,4F15I@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_1286889_1	710686.Mycsm_04043	7.11e-46	162.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria,232BW@1762|Mycobacteriaceae	201174|Actinobacteria	L	PFAM Transposase, IS116 IS110 IS902	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,HTH_31,Transposase_20
k59_1286890_1	240016.ABIZ01000001_gene5350	5.44e-35	131.0	COG3267@1|root,COG3267@2|Bacteria,46XMZ@74201|Verrucomicrobia,2IW82@203494|Verrucomicrobiae	203494|Verrucomicrobiae	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
k59_338717_1	1408418.JNJH01000010_gene3479	1.09e-68	219.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,2U1D1@28211|Alphaproteobacteria,2JSI1@204441|Rhodospirillales	204441|Rhodospirillales	S	Haloacid dehalogenase-like hydrolase	cbbY	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_866669_2	742741.HMPREF9475_00856	1.44e-11	68.6	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,21Y7U@1506553|Lachnoclostridium	186801|Clostridia	D	Peptidase family M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
k59_1038549_2	388467.A19Y_2860	1.3e-20	84.0	COG4456@1|root,COG4456@2|Bacteria,1G95Y@1117|Cyanobacteria,1HCTC@1150|Oscillatoriales	1117|Cyanobacteria	S	Virulence associated protein B	vapB	-	-	ko:K18829	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
k59_1112100_1	1304865.JAGF01000001_gene3732	9.41e-131	382.0	COG0111@1|root,COG0111@2|Bacteria,2GJGA@201174|Actinobacteria,4F0U9@85016|Cellulomonadaceae	201174|Actinobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase catalytic region	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_220650_1	1267535.KB906767_gene2392	9.78e-21	86.7	COG1846@1|root,COG1846@2|Bacteria,3Y861@57723|Acidobacteria	57723|Acidobacteria	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_34
k59_220650_2	1340493.JNIF01000003_gene1914	1.89e-25	100.0	COG3127@1|root,COG3127@2|Bacteria	2|Bacteria	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1038554_2	1049564.TevJSym_ac00400	7e-23	97.1	COG0741@1|root,COG0741@2|Bacteria	2|Bacteria	M	lytic transglycosylase activity	-	-	-	-	-	-	-	-	-	-	-	-	SLT,SPOR
k59_1689396_1	1137799.GZ78_11890	2.88e-15	81.6	COG0457@1|root,COG0457@2|Bacteria,1MVCA@1224|Proteobacteria,1RS02@1236|Gammaproteobacteria,1XKYA@135619|Oceanospirillales	135619|Oceanospirillales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
k59_1689398_1	261292.Nit79A3_0630	1.39e-94	284.0	COG1656@1|root,COG1977@1|root,COG1656@2|Bacteria,COG1977@2|Bacteria,1R442@1224|Proteobacteria,2VN8Q@28216|Betaproteobacteria,372YJ@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Mut7-C ubiquitin	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
k59_866689_1	765913.ThidrDRAFT_1728	1.18e-62	196.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1WXDE@135613|Chromatiales	135613|Chromatiales	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_1801732_1	1134474.O59_003367	5.53e-28	114.0	COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,1FFRU@10|Cellvibrio	1236|Gammaproteobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_572288_1	1454010.JEOE01000025_gene2958	2.52e-75	231.0	COG0125@1|root,COG0125@2|Bacteria,2GNTI@201174|Actinobacteria,4F26H@85016|Cellulomonadaceae	201174|Actinobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_1,MFS_3,Thymidylate_kin
k59_572288_2	446469.Sked_32580	2.02e-108	324.0	COG0470@1|root,COG0470@2|Bacteria,2GJ8C@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase III	holB	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
k59_1521002_1	1123367.C666_00115	1.03e-13	75.1	COG5652@1|root,COG5652@2|Bacteria,1R5TU@1224|Proteobacteria,2VVM2@28216|Betaproteobacteria	28216|Betaproteobacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
k59_1801742_1	1049564.TevJSym_au00120	1.17e-83	258.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1J4KY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	GO:0001522,GO:0003674,GO:0003824,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016769,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	iPC815.YPO2896,iYL1228.KPN_02862	Aminotran_5
k59_1628314_1	237609.PSAKL28_52660	9.68e-76	242.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009226,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0018130,GO:0019134,GO:0019438,GO:0030203,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0042546,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046872,GO:0055086,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903509	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iECED1_1282.ECED1_4420,iYL1228.KPN_04135	Hexapep,Hexapep_2,NTP_transf_3
k59_1628323_3	2340.JV46_14290	1.64e-11	64.3	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_513768_1	631362.Thi970DRAFT_03958	4.94e-67	218.0	COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,1RR67@1236|Gammaproteobacteria,1WX31@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_1286952_1	1223542.GM1_003_01660	1.37e-12	75.1	COG5361@1|root,COG5361@2|Bacteria,2GKTA@201174|Actinobacteria,4GBT8@85026|Gordoniaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1570227_1	1123065.ATWL01000011_gene71	3.84e-227	653.0	COG4581@1|root,COG4581@2|Bacteria,2GJSV@201174|Actinobacteria	201174|Actinobacteria	L	dead DEAH box helicase	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,DUF3516,Helicase_C
k59_1521041_1	1211114.ALIP01000112_gene1797	2.25e-21	93.2	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1X3NP@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1286961_1	335543.Sfum_2955	2e-91	285.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42NWT@68525|delta/epsilon subdivisions,2X5DA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1154784_1	177437.HRM2_46710	1.99e-121	355.0	COG1456@1|root,COG1456@2|Bacteria,1R8JC@1224|Proteobacteria,42Q7Q@68525|delta/epsilon subdivisions,2WJXT@28221|Deltaproteobacteria,2MIQZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF3786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786,FeS
k59_338799_1	309807.SRU_2221	1.24e-55	190.0	COG0165@1|root,COG0165@2|Bacteria,4NFCY@976|Bacteroidetes,1FJSI@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Lyase_1
k59_1154790_1	1117647.M5M_10885	1.46e-159	462.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,1J5GX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	alsS	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_690605_1	497964.CfE428DRAFT_5240	5.8e-40	141.0	COG2326@1|root,COG2326@2|Bacteria,46SAH@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_690605_2	768710.DesyoDRAFT_3674	1.8e-10	62.4	COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,260C5@186807|Peptococcaceae	186801|Clostridia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_631355_1	765910.MARPU_04430	1.82e-17	81.6	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1WW6G@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_631355_2	1266914.ATUK01000013_gene1979	5.8e-63	214.0	COG1205@1|root,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,1S0XD@1236|Gammaproteobacteria,1WXNC@135613|Chromatiales	135613|Chromatiales	L	DEAD DEAH box	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
k59_1689475_2	768671.ThimaDRAFT_3682	7.7e-158	451.0	COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,1RZ0T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_1454587_1	1278309.KB907101_gene627	2.22e-51	181.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1XI2V@135619|Oceanospirillales	135619|Oceanospirillales	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	mltD	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_1154800_1	1454010.JEOE01000047_gene1916	1.05e-05	47.0	29S1Z@1|root,30D6E@2|Bacteria,2HXXN@201174|Actinobacteria,4F1K8@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1219261_1	118161.KB235918_gene79	2.82e-41	143.0	COG3415@1|root,COG3415@2|Bacteria,1GEDQ@1117|Cyanobacteria	1117|Cyanobacteria	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
k59_1394244_1	1122130.AUHN01000012_gene2634	1.84e-05	46.2	COG0382@1|root,COG0382@2|Bacteria,2GKJ2@201174|Actinobacteria	201174|Actinobacteria	H	UbiA prenyltransferase	ubiA	-	-	ko:K20616	-	-	-	-	ko00000	-	-	-	UbiA
k59_1628395_1	296591.Bpro_4054	7.55e-118	367.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VH05@28216|Betaproteobacteria,4AC69@80864|Comamonadaceae	28216|Betaproteobacteria	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_1112211_1	983917.RGE_35290	1.67e-241	681.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2VH5H@28216|Betaproteobacteria,1KK94@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_1628403_1	1116472.MGMO_176c00130	7.53e-18	83.2	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,1SCZX@1236|Gammaproteobacteria,1XFHW@135618|Methylococcales	135618|Methylococcales	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
k59_1521090_1	323261.Noc_2184	1.54e-80	246.0	COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,1SYJC@1236|Gammaproteobacteria,1WW83@135613|Chromatiales	135613|Chromatiales	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1521090_2	1249627.D779_4168	1.96e-75	237.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,1WXR0@135613|Chromatiales	135613|Chromatiales	G	Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides	nagZ	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
k59_1570289_1	1116472.MGMO_71c00080	4.83e-91	288.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria,1XEH4@135618|Methylococcales	135618|Methylococcales	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_1801810_2	1122605.KB893647_gene272	4.22e-16	82.0	COG1033@1|root,COG1033@2|Bacteria,4NE0M@976|Bacteroidetes,1IQCU@117747|Sphingobacteriia	976|Bacteroidetes	S	of the RND superfamily	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_513824_1	316274.Haur_4823	4.53e-57	194.0	COG1109@1|root,COG1109@2|Bacteria,2G5Y4@200795|Chloroflexi	200795|Chloroflexi	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_572370_1	670292.JH26_02420	8.93e-58	198.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,TPR_2,TPR_8
k59_1521107_1	518766.Rmar_2465	5.53e-85	275.0	COG0542@1|root,COG0542@2|Bacteria,4NGEM@976|Bacteroidetes,1FISE@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1521111_1	396588.Tgr7_1535	1.08e-75	250.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1WXK8@135613|Chromatiales	135613|Chromatiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_690656_1	1000565.METUNv1_03634	3.23e-43	152.0	COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,2VJW8@28216|Betaproteobacteria,2KWIW@206389|Rhodocyclales	206389|Rhodocyclales	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Guanylate_cyc
k59_1112247_1	272942.RCAP_rcc00462	4.67e-94	283.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2TQNE@28211|Alphaproteobacteria,1FAWI@1060|Rhodobacter	28211|Alphaproteobacteria	H	Belongs to the prokaryotic GSH synthase family	gshB	GO:0003674,GO:0003824,GO:0004363,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
k59_1394289_1	525368.HMPREF0591_5888	1.04e-37	145.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,2I2RH@201174|Actinobacteria,2358D@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Acyltransferase,PP-binding
k59_1628442_1	1121406.JAEX01000001_gene427	1.4e-35	131.0	2C5J8@1|root,30F9Z@2|Bacteria,1RE16@1224|Proteobacteria,42RYB@68525|delta/epsilon subdivisions,2WNIF@28221|Deltaproteobacteria,2MB2J@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_513843_1	935863.AWZR01000001_gene1746	1.51e-110	334.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,1X33U@135614|Xanthomonadales	135614|Xanthomonadales	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	actP	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_1521129_1	187303.BN69_0845	3.96e-104	314.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,2TYKR@28211|Alphaproteobacteria,36Z9G@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Nickel-dependent hydrogenase	-	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
k59_1570338_1	1177181.T9A_00237	1.89e-73	245.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XN31@135619|Oceanospirillales	135619|Oceanospirillales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1801843_1	1255043.TVNIR_1575	1.2e-06	48.5	COG1051@1|root,COG1051@2|Bacteria,1N03W@1224|Proteobacteria,1S970@1236|Gammaproteobacteria,1X18A@135613|Chromatiales	135613|Chromatiales	F	Belongs to the Nudix hydrolase family. NudJ subfamily	nudJ	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_1801843_2	580332.Slit_1670	8.27e-33	124.0	COG3439@1|root,COG3439@2|Bacteria,1MXYT@1224|Proteobacteria,2W0RY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1747052_1	41431.PCC8801_1622	6.36e-08	57.0	COG4803@1|root,COG4803@2|Bacteria,1G531@1117|Cyanobacteria,3KHQE@43988|Cyanothece	1117|Cyanobacteria	S	PFAM membrane protein of uknown function UCP014873	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
k59_1521146_1	396588.Tgr7_0724	5.86e-10	58.5	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,1S668@1236|Gammaproteobacteria,1WYAA@135613|Chromatiales	135613|Chromatiales	G	PTS IIA-like nitrogen-regulatory protein PtsN	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
k59_1521146_2	1000565.METUNv1_03641	1.21e-31	114.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2VU5H@28216|Betaproteobacteria,2KWTT@206389|Rhodocyclales	206389|Rhodocyclales	J	sigma 54 modulation protein	-	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
k59_1521146_3	349124.Hhal_2126	1.77e-51	177.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1WVZD@135613|Chromatiales	135613|Chromatiales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_1747060_1	713586.KB900536_gene299	6.88e-105	335.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales	135613|Chromatiales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_222432_1	1454010.JEOE01000010_gene2785	2.73e-57	196.0	COG2844@1|root,COG2844@2|Bacteria,2GMKT@201174|Actinobacteria,4F0YZ@85016|Cellulomonadaceae	201174|Actinobacteria	O	metal-dependent phosphohydrolase HD sub domain	glnD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_222437_1	754477.Q7C_715	1.93e-26	112.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,4604N@72273|Thiotrichales	72273|Thiotrichales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_1571978_1	394221.Mmar10_0249	1.83e-135	410.0	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria,43W98@69657|Hyphomonadaceae	28211|Alphaproteobacteria	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_1748391_1	1304865.JAGF01000001_gene3254	1.48e-86	262.0	COG1396@1|root,COG1396@2|Bacteria,2GJS3@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
k59_456352_1	670307.HYPDE_37783	6.54e-88	270.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2TR6G@28211|Alphaproteobacteria,3N69S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_1691134_1	1894.JOER01000006_gene854	2.26e-31	130.0	COG0596@1|root,COG0596@2|Bacteria,2GJYS@201174|Actinobacteria	201174|Actinobacteria	NU	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
k59_1803095_1	745310.G432_06970	1.12e-46	159.0	COG0824@1|root,COG0824@2|Bacteria,1R6A6@1224|Proteobacteria,2TU6J@28211|Alphaproteobacteria,2K9RB@204457|Sphingomonadales	204457|Sphingomonadales	S	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_573660_1	269482.Bcep1808_0276	8.37e-41	149.0	COG3328@1|root,COG3328@2|Bacteria,1R81T@1224|Proteobacteria,2W75T@28216|Betaproteobacteria,1KDWC@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM transposase, mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_573660_2	1038869.AXAN01000264_gene587	1.02e-26	106.0	COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2VWYN@28216|Betaproteobacteria,1K8UX@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	Transposase_20
k59_1456220_1	1144325.PMI22_00608	9.33e-78	248.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1S3FP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1632046_1	765698.Mesci_6352	1.29e-38	142.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2TUNK@28211|Alphaproteobacteria,43J11@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_1692870_1	367299.JOEE01000005_gene3439	1.89e-88	271.0	COG0438@1|root,COG0438@2|Bacteria,2GN28@201174|Actinobacteria,4FFRJ@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
k59_1692870_2	367299.JOEE01000005_gene3440	4.39e-59	197.0	COG0504@1|root,COG0504@2|Bacteria,2GJ13@201174|Actinobacteria,4FF55@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1699	CTP_synth_N,GATase
k59_166123_1	479431.Namu_4263	2.45e-107	334.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4EU8Y@85013|Frankiales	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K12950,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.32,3.A.3.5	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
k59_1397565_1	335543.Sfum_3278	4.58e-154	442.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,42KZT@68525|delta/epsilon subdivisions,2WIXY@28221|Deltaproteobacteria,2MR0X@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	PFAM AIR synthase related protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1844	AIRS,AIRS_C
k59_1525382_2	1121405.dsmv_3295	3.76e-40	142.0	COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,42MH1@68525|delta/epsilon subdivisions,2WJD7@28221|Deltaproteobacteria,2MI33@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Na transporting methylmalonyl-CoA oxaloacetate decarboxylase beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
k59_457747_2	1304865.JAGF01000001_gene3884	3.94e-56	182.0	COG0834@1|root,COG0834@2|Bacteria,2GJQW@201174|Actinobacteria,4F2KS@85016|Cellulomonadaceae	201174|Actinobacteria	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_870430_1	1502850.FG91_02325	6.8e-74	232.0	COG0451@1|root,COG0451@2|Bacteria,1MVI8@1224|Proteobacteria,2TT7Q@28211|Alphaproteobacteria,2KCUW@204457|Sphingomonadales	204457|Sphingomonadales	GM	NmrA-like family	-	-	5.1.3.7	ko:K02473	ko00520,ko01100,map00520,map01100	-	R00418	RC00289	ko00000,ko00001,ko01000	-	-	-	-
k59_1222611_1	243233.MCA2400	1.55e-23	99.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,1RQ01@1236|Gammaproteobacteria,1XE9J@135618|Methylococcales	135618|Methylococcales	P	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
k59_1222611_2	395494.Galf_0768	1.28e-52	171.0	COG2010@1|root,COG2010@2|Bacteria,1RG22@1224|Proteobacteria,2W8VP@28216|Betaproteobacteria,44WMU@713636|Nitrosomonadales	1224|Proteobacteria	C	PFAM cytochrome c class I	-	-	-	ko:K02305	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002	3.D.4.10	-	-	Cytochrom_C
k59_341914_2	1392490.JHZX01000001_gene846	7.81e-20	89.0	COG0296@1|root,COG0296@2|Bacteria,4NJ7Z@976|Bacteroidetes,1HZ6E@117743|Flavobacteriia	976|Bacteroidetes	G	Glycogen recognition site of AMP-activated protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM
k59_1804479_1	335543.Sfum_2413	6.23e-59	206.0	COG3523@1|root,COG3523@2|Bacteria,1NRHK@1224|Proteobacteria,42Z87@68525|delta/epsilon subdivisions,2WTYM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1291248_2	926564.KI911753_gene6139	5.77e-12	61.2	2EG89@1|root,33A03@2|Bacteria,2GX3U@201174|Actinobacteria,4F4Y5@85017|Promicromonosporaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1291248_3	446471.Xcel_1031	2.33e-41	150.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria,4F47R@85017|Promicromonosporaceae	201174|Actinobacteria	NU	Type ii secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
k59_1222617_1	1122201.AUAZ01000005_gene606	4.21e-21	88.2	COG3658@1|root,COG3658@2|Bacteria,1N28F@1224|Proteobacteria,1S2S2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	PFAM Di-haem cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	DHC
k59_1222617_2	396588.Tgr7_0587	2.94e-13	67.4	COG3212@1|root,COG3212@2|Bacteria,1NHDB@1224|Proteobacteria,1SCJ2@1236|Gammaproteobacteria,1WZB8@135613|Chromatiales	135613|Chromatiales	S	PFAM Propeptide PepSY amd peptidase M4	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
k59_575098_1	585423.KR49_07905	6.29e-25	106.0	28HMZ@1|root,2Z7WD@2|Bacteria,1G31X@1117|Cyanobacteria,1H044@1129|Synechococcus	1117|Cyanobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_224256_1	593907.Celgi_2024	1.98e-81	264.0	COG1199@1|root,COG1199@2|Bacteria,2GKT8@201174|Actinobacteria,4F0ZQ@85016|Cellulomonadaceae	201174|Actinobacteria	KL	HELICc2	dinG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
k59_224261_1	160799.PBOR_09795	3.82e-31	124.0	COG1331@1|root,COG1331@2|Bacteria,1TQ83@1239|Firmicutes,4HEH5@91061|Bacilli,26S2R@186822|Paenibacillaceae	91061|Bacilli	O	Glycosyl hydrolase	-	-	3.2.1.180	ko:K18581	-	-	R10867	RC00049,RC02427	ko00000,ko01000	-	GH88	-	Glyco_hydro_88
k59_516096_1	765912.Thimo_0506	3.27e-09	61.6	2DWCI@1|root,33ZMQ@2|Bacteria,1NXC9@1224|Proteobacteria,1SQEH@1236|Gammaproteobacteria,1X12A@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_802204_1	1304865.JAGF01000001_gene1273	1.12e-45	155.0	COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria,4F17R@85016|Cellulomonadaceae	201174|Actinobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	fhaB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
k59_802204_2	471853.Bcav_0032	3.4e-56	180.0	COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria	201174|Actinobacteria	T	(FHA) domain	fhaA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA,Yop-YscD_cpl
k59_516099_1	870187.Thini_0322	7.5e-88	283.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,460EP@72273|Thiotrichales	72273|Thiotrichales	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1804508_1	713586.KB900536_gene2963	3.34e-46	162.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1WVUR@135613|Chromatiales	135613|Chromatiales	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
k59_1222665_1	396588.Tgr7_2479	1.63e-18	92.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,dCache_1
k59_1397651_2	1349767.GJA_4537	0.000379	43.5	COG5393@1|root,COG5393@2|Bacteria,1PUGN@1224|Proteobacteria,2VY8I@28216|Betaproteobacteria,474Z3@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
k59_693871_1	1313172.YM304_15900	1.88e-67	228.0	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4CMS2@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_1632168_1	177437.HRM2_37820	9.7e-06	52.8	COG0589@1|root,COG0589@2|Bacteria,1REA3@1224|Proteobacteria,42RXY@68525|delta/epsilon subdivisions,2WNM6@28221|Deltaproteobacteria,2MJWG@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_802230_1	1049564.TevJSym_ay00240	2.89e-129	383.0	COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,1RPDV@1236|Gammaproteobacteria,1J5GA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1692971_2	1249627.D779_2946	2.54e-37	135.0	2DXMK@1|root,32V3Q@2|Bacteria,1N6HJ@1224|Proteobacteria,1SB4I@1236|Gammaproteobacteria,1WZ1G@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1692971_3	1249627.D779_2947	1.83e-51	179.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria,1WWCP@135613|Chromatiales	135613|Chromatiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_457808_1	522306.CAP2UW1_0608	5.76e-89	275.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2VI55@28216|Betaproteobacteria,1KQ7E@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_753189_1	1380394.JADL01000004_gene5834	1.4e-105	325.0	COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,2TQUR@28211|Alphaproteobacteria,2JPYE@204441|Rhodospirillales	204441|Rhodospirillales	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
k59_166238_2	502558.EGYY_10460	1.53e-38	140.0	COG0264@1|root,COG0264@2|Bacteria,2GK4M@201174|Actinobacteria,4CU7J@84998|Coriobacteriia	84998|Coriobacteriia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_575150_2	1120972.AUMH01000009_gene539	8.04e-31	122.0	COG0297@1|root,COG1543@1|root,COG0297@2|Bacteria,COG1543@2|Bacteria,1TPFX@1239|Firmicutes,4ITP1@91061|Bacilli,27ATI@186823|Alicyclobacillaceae	91061|Bacilli	G	Domain of unknown function (DUF1957)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1957,Glyco_hydro_57,Glyco_transf_4,Glycos_transf_1
k59_1291330_1	367299.JOEE01000003_gene2825	6.15e-142	434.0	COG5013@1|root,COG5013@2|Bacteria,2GKZU@201174|Actinobacteria,4FF95@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narZ	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding
k59_575154_1	522306.CAP2UW1_3401	4.35e-28	114.0	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VHA3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Phospholipase, patatin family	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_1397681_1	1121918.ARWE01000001_gene2207	5.37e-79	253.0	COG2204@1|root,COG3829@1|root,COG2204@2|Bacteria,COG3829@2|Bacteria,1MU0N@1224|Proteobacteria,43BR8@68525|delta/epsilon subdivisions,2X724@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
k59_1043151_1	1463887.KL590062_gene1853	7.57e-20	84.0	COG2963@1|root,COG2963@2|Bacteria,2IN3E@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1043151_2	1217720.ALOX01000216_gene2744	7.41e-110	327.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_1397683_1	1249627.D779_3389	1.68e-55	186.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1WWNX@135613|Chromatiales	135613|Chromatiales	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_870546_1	471853.Bcav_0608	2.24e-94	281.0	COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	glxR	GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_1397685_1	1255043.TVNIR_0090	9.14e-33	126.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1WXMK@135613|Chromatiales	135613|Chromatiales	S	Polyphosphate AMP phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_1397685_2	1123504.JQKD01000050_gene745	4.38e-29	112.0	COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VS6Z@28216|Betaproteobacteria,4ADJG@80864|Comamonadaceae	28216|Betaproteobacteria	S	gag-polyprotein putative aspartyl protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
k59_1632203_1	1194165.CAJF01000012_gene918	1.03e-35	127.0	COG0175@1|root,COG0175@2|Bacteria,2GJ3Z@201174|Actinobacteria,4FMSW@85023|Microbacteriaceae	201174|Actinobacteria	EH	Phosphoadenosine phosphosulfate reductase family	cysH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004604,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016667,GO:0016671,GO:0019344,GO:0019752,GO:0040007,GO:0043436,GO:0043866,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2392	PAPS_reduct
k59_1632203_2	1713.JOFV01000005_gene2132	1.96e-100	300.0	COG0175@1|root,COG0175@2|Bacteria,2GN85@201174|Actinobacteria,4F1WB@85016|Cellulomonadaceae	201174|Actinobacteria	EH	TIGRFAM sulfate adenylyltransferase, small subunit	cysD	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
k59_575166_1	471853.Bcav_0699	1.28e-61	202.0	COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria	201174|Actinobacteria	S	protein, coenzyme F420 biosynthesis associated	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
k59_634246_1	1200792.AKYF01000010_gene2832	8.59e-29	122.0	COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,4HV3C@91061|Bacilli,26VJF@186822|Paenibacillaceae	91061|Bacilli	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,fn3
k59_870571_1	391615.ABSJ01000054_gene1414	7.41e-96	288.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,1J5B6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004073,GO:0006082,GO:0006520,GO:0006549,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009097,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_1397704_1	472759.Nhal_0597	6.6e-39	146.0	COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,1RMMI@1236|Gammaproteobacteria,1X2Q0@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS_8
k59_1574093_1	1415778.JQMM01000001_gene1480	8.32e-32	122.0	COG0672@1|root,COG0672@2|Bacteria,1N48M@1224|Proteobacteria,1S7GF@1236|Gammaproteobacteria,1J6PW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0672 High-affinity Fe2 Pb2 permease	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
k59_802278_1	211114.JOEF01000037_gene6865	0.000223	43.9	2E5TF@1|root,330HT@2|Bacteria,2IRYP@201174|Actinobacteria,4ECMC@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_166298_2	754476.Q7A_1243	2.01e-53	172.0	COG1585@1|root,COG1585@2|Bacteria,1N241@1224|Proteobacteria,1S5W4@1236|Gammaproteobacteria,462TR@72273|Thiotrichales	72273|Thiotrichales	OU	of membrane protease	-	-	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
k59_166298_3	1380391.JIAS01000020_gene1643	1.84e-14	72.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2TRUY@28211|Alphaproteobacteria,2JPF8@204441|Rhodospirillales	204441|Rhodospirillales	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
k59_803869_2	1123070.KB899247_gene1449	2.58e-29	113.0	COG0803@1|root,COG0803@2|Bacteria,46TZH@74201|Verrucomicrobia,2IVSM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Zinc-uptake complex component A periplasmic	-	-	-	-	-	-	-	-	-	-	-	-	ZnuA
k59_517414_1	768671.ThimaDRAFT_2183	2.11e-154	446.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1WWHC@135613|Chromatiales	135613|Chromatiales	J	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
k59_1806076_1	95619.PM1_0201865	5.89e-195	556.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	glnG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1806076_2	1000565.METUNv1_00083	2.26e-08	55.1	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2VJN7@28216|Betaproteobacteria,2KUZZ@206389|Rhodocyclales	206389|Rhodocyclales	T	Signal transduction histidine kinase, nitrogen specific	ntrB	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
k59_1576164_1	1122925.KB895388_gene1864	3.84e-68	219.0	COG0436@1|root,COG0436@2|Bacteria,1TQD6@1239|Firmicutes,4HAHQ@91061|Bacilli,26QSS@186822|Paenibacillaceae	91061|Bacilli	E	Produces methionine from 2-keto-4-methylthiobutyrate and glutamine in vitro	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_695613_1	2340.JV46_14330	4.08e-91	288.0	COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_226214_1	1121405.dsmv_0058	8.85e-114	339.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42MWF@68525|delta/epsilon subdivisions,2WKAQ@28221|Deltaproteobacteria,2MIMD@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lysin motif	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_1806087_1	436717.AOLE_08915	1.35e-20	91.3	COG2303@1|root,COG2303@2|Bacteria,1NV3A@1224|Proteobacteria,1RNQ5@1236|Gammaproteobacteria,3NMPR@468|Moraxellaceae	1236|Gammaproteobacteria	E	GMC oxidoreductase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_1806087_2	1288826.MSNKSG1_12787	4.95e-48	169.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RN7X@1236|Gammaproteobacteria,4665Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	COG1960 Acyl-CoA dehydrogenases	aidB	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
k59_1576180_1	1430440.MGMSRv2_4253	3.57e-48	176.0	COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2208@2|Bacteria,1N4K5@1224|Proteobacteria,2TS77@28211|Alphaproteobacteria,2JTVU@204441|Rhodospirillales	204441|Rhodospirillales	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
k59_1045496_1	439235.Dalk_0887	1.88e-80	270.0	COG0366@1|root,COG3408@1|root,COG0366@2|Bacteria,COG3408@2|Bacteria,1MWBZ@1224|Proteobacteria,43AE9@68525|delta/epsilon subdivisions,2X5U3@28221|Deltaproteobacteria,2MJ5S@213118|Desulfobacterales	28221|Deltaproteobacteria	G	alpha amylase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,GDE_C,GDE_N
k59_168189_1	84531.JMTZ01000024_gene4027	2.17e-48	176.0	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,1X4M7@135614|Xanthomonadales	135614|Xanthomonadales	I	Belongs to the GPAT DAPAT family	plsB	-	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_226235_1	1500890.JQNL01000001_gene2640	7e-27	108.0	COG2518@1|root,COG2518@2|Bacteria,1PAS9@1224|Proteobacteria,1T5ZJ@1236|Gammaproteobacteria,1X8XX@135614|Xanthomonadales	135614|Xanthomonadales	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1045518_1	1304885.AUEY01000004_gene943	3.01e-104	319.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2WJ2N@28221|Deltaproteobacteria,2MI0Z@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_1806105_1	402881.Plav_2978	1.24e-103	308.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,2TRTI@28211|Alphaproteobacteria,1JN7U@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
k59_1695080_1	1089447.RHAA1_07048	2.5e-112	334.0	COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,1RPG5@1236|Gammaproteobacteria,1Y7ED@135625|Pasteurellales	135625|Pasteurellales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway	nqrF	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
k59_755219_2	344747.PM8797T_10494	4.09e-14	72.8	COG0531@1|root,COG0531@2|Bacteria,2J25Q@203682|Planctomycetes	203682|Planctomycetes	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_1806111_1	1125971.ASJB01000099_gene2286	2.71e-33	127.0	COG0842@1|root,COG0842@2|Bacteria,2I0HP@201174|Actinobacteria,4E1P2@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_635833_1	713586.KB900536_gene2316	9.67e-36	131.0	COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,1S739@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
k59_1806113_1	768671.ThimaDRAFT_2241	4.09e-86	278.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1WXI8@135613|Chromatiales	135613|Chromatiales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_347354_2	1121440.AUMA01000007_gene1107	2.44e-05	46.2	2EAFJ@1|root,334IY@2|Bacteria,1NA2Y@1224|Proteobacteria,42VJ1@68525|delta/epsilon subdivisions,2WRKE@28221|Deltaproteobacteria,2MCVH@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1844)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1844
k59_462877_1	266264.Rmet_0890	1.09e-66	214.0	COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria,2VI56@28216|Betaproteobacteria,1JZTV@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism	add	-	3.5.4.2	ko:K21053	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
k59_1754848_1	1122933.JNIY01000003_gene769	2.35e-101	333.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GM2E@201174|Actinobacteria,4F10D@85016|Cellulomonadaceae	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD2	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1580693_1	1415779.JOMH01000001_gene188	7.84e-84	255.0	COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,1RMVD@1236|Gammaproteobacteria,1X39H@135614|Xanthomonadales	135614|Xanthomonadales	G	Inositol monophosphatase family	-	-	3.1.3.15	ko:K05602	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_807093_1	1121479.AUBS01000025_gene529	2.36e-83	255.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2TSK2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TRAP transporter solute receptor TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_1754850_1	207559.Dde_1183	2e-23	97.8	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,43B4R@68525|delta/epsilon subdivisions,2X5VN@28221|Deltaproteobacteria,2MGWB@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034,ko:K12370	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_1463245_1	1433126.BN938_0150	5.33e-25	102.0	COG0714@1|root,COG0714@2|Bacteria,4NDVZ@976|Bacteroidetes,2FMGP@200643|Bacteroidia,22U05@171550|Rikenellaceae	976|Bacteroidetes	S	ATPase family associated with various cellular activities (AAA)	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1463245_2	1121087.AUCK01000029_gene271	5.32e-21	89.4	COG0219@1|root,COG0219@2|Bacteria,1V3GW@1239|Firmicutes,4HFNY@91061|Bacilli,1ZFKH@1386|Bacillus	91061|Bacilli	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	cspR	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
k59_172201_1	269799.Gmet_1296	4.09e-34	119.0	COG2840@1|root,COG2840@2|Bacteria,1QX48@1224|Proteobacteria,43BWQ@68525|delta/epsilon subdivisions,2X77I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Smr domain	-	-	-	-	-	-	-	-	-	-	-	-	Smr
k59_172201_2	1232437.KL662072_gene1802	4.79e-16	77.4	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2MJFX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	pcmT	-	1.17.1.4,1.3.7.9	ko:K00087,ko:K04108	ko00230,ko00362,ko00627,ko01100,ko01120,ko01220,map00230,map00362,map00627,map01100,map01120,map01220	M00546	R01768,R02103,R05316	RC00143,RC00490	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_1699246_1	1123367.C666_19070	1.94e-90	275.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2VI1H@28216|Betaproteobacteria,2KXNX@206389|Rhodocyclales	206389|Rhodocyclales	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_172208_2	754477.Q7C_1487	4.21e-67	218.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,460KP@72273|Thiotrichales	72273|Thiotrichales	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_462908_1	2340.JV46_27600	3.96e-83	256.0	COG3302@1|root,COG3302@2|Bacteria,1MWY1@1224|Proteobacteria,1RS3Q@1236|Gammaproteobacteria,1JB7K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	DMSO reductase anchor subunit (DmsC)	dmsC	-	-	ko:K21309	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001	-	-	-	DmsC
k59_462908_2	765911.Thivi_1881	9.16e-39	141.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RNPY@1236|Gammaproteobacteria,1WWN2@135613|Chromatiales	135613|Chromatiales	O	PFAM peptidase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
k59_1050582_1	880072.Desac_0827	1.17e-75	242.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43DC7@68525|delta/epsilon subdivisions,2X8I7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
k59_1404131_1	313624.NSP_34410	3.87e-19	91.3	COG0668@1|root,COG4447@1|root,COG0668@2|Bacteria,COG4447@2|Bacteria,1G0ZM@1117|Cyanobacteria,1HJAZ@1161|Nostocales	1117|Cyanobacteria	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
k59_1580717_1	1156937.MFUM_970073	4.81e-100	303.0	COG1004@1|root,COG1004@2|Bacteria,46S6E@74201|Verrucomicrobia,37GBP@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	UDP binding domain	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_1809689_1	1123368.AUIS01000008_gene2237	6.82e-44	153.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,1T90P@1236|Gammaproteobacteria,2NDQR@225057|Acidithiobacillales	225057|Acidithiobacillales	C	Radical SAM superfamily	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
k59_1809689_2	1122962.AULH01000025_gene3366	6.2e-22	94.7	COG1121@1|root,COG1121@2|Bacteria,1MW47@1224|Proteobacteria,2TRJA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC transporter	sitB	-	-	ko:K11607	ko02010,map02010	M00317	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.7,3.A.1.15.9	-	-	ABC_tran
k59_699236_1	926550.CLDAP_19740	6.07e-19	91.7	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2G5ZQ@200795|Chloroflexi	200795|Chloroflexi	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8
k59_1162891_1	257310.BB0233	1.63e-102	316.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,3T1XK@506|Alcaligenaceae	28216|Betaproteobacteria	I	Long-chain acyl-CoA synthetases (AMP-forming)	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_877381_2	396588.Tgr7_1833	7.79e-30	119.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1WWGC@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1809690_1	96561.Dole_2348	2.98e-72	238.0	COG0507@1|root,COG1948@1|root,COG0507@2|Bacteria,COG1948@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2WJD6@28221|Deltaproteobacteria,2MINC@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
k59_1580723_1	1167006.UWK_02601	1.38e-77	251.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MI87@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1,Acetyltransf_3
k59_1699274_1	765911.Thivi_0827	1.83e-98	308.0	COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,1T58S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,ResIII
k59_1404140_1	1120959.ATXF01000004_gene2957	1.46e-70	221.0	COG0110@1|root,COG0110@2|Bacteria,2H5M0@201174|Actinobacteria,4FNDH@85023|Microbacteriaceae	201174|Actinobacteria	S	Hexapeptide repeat of succinyl-transferase	wbpD	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
k59_1637985_1	572477.Alvin_1555	3.2e-36	137.0	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,1RPAE@1236|Gammaproteobacteria,1WYC8@135613|Chromatiales	135613|Chromatiales	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_172233_1	1303518.CCALI_00041	3.2e-127	383.0	COG0334@1|root,COG0334@2|Bacteria	2|Bacteria	E	glutamate dehydrogenase [NAD(P)+] activity	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_1754898_1	545264.KB898744_gene2071	5.84e-08	60.8	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_1754900_1	1209984.BN978_04800	2.24e-76	255.0	COG0464@1|root,COG0464@2|Bacteria,2I8CR@201174|Actinobacteria,2389U@1762|Mycobacteriaceae	201174|Actinobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_1809716_1	187272.Mlg_0857	1.29e-06	53.1	COG4970@1|root,COG4970@2|Bacteria	2|Bacteria	NU	protein transport across the cell outer membrane	-	-	-	ko:K08084	-	-	-	-	ko00000,ko02044	3.A.15.2	-	-	GspH,N_methyl
k59_1809716_2	690850.Desaf_1238	3.25e-26	99.8	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,42SFB@68525|delta/epsilon subdivisions,2WP3B@28221|Deltaproteobacteria,2MBZA@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	PFAM type II secretion system protein G	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
k59_520100_1	652103.Rpdx1_3857	2.8e-32	129.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,3JQNW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	actP	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
k59_1229072_1	323848.Nmul_A2249	2.48e-24	94.0	COG3360@1|root,COG3360@2|Bacteria,1PW6C@1224|Proteobacteria,2VXDE@28216|Betaproteobacteria,373H6@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
k59_1229072_2	795666.MW7_2341	5.2e-13	70.1	COG0664@1|root,COG0664@2|Bacteria,1N3F0@1224|Proteobacteria,2VVAQ@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_1404163_1	82996.sch_24970	1.05e-37	138.0	COG4874@1|root,COG4874@2|Bacteria,1N05R@1224|Proteobacteria,1S34T@1236|Gammaproteobacteria,401IV@613|Serratia	1236|Gammaproteobacteria	S	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
k59_1229089_1	261292.Nit79A3_3408	1.22e-11	60.5	COG4118@1|root,COG4118@2|Bacteria,1N7BG@1224|Proteobacteria,2VY0B@28216|Betaproteobacteria	28216|Betaproteobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
k59_172277_1	195253.Syn6312_1991	4.44e-11	67.4	COG3128@1|root,COG3128@2|Bacteria,1G72M@1117|Cyanobacteria	1117|Cyanobacteria	S	Prolyl 4-hydroxylase alpha subunit homologues.	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_3
k59_1463318_2	448385.sce2244	3.24e-47	157.0	COG1247@1|root,COG1247@2|Bacteria,1QW9G@1224|Proteobacteria,43CUJ@68525|delta/epsilon subdivisions,2WY2V@28221|Deltaproteobacteria,2Z2KE@29|Myxococcales	28221|Deltaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
k59_1463318_3	717774.Marme_1540	4.24e-11	60.5	2E5AU@1|root,3302Y@2|Bacteria,1RFJF@1224|Proteobacteria,1TAP8@1236|Gammaproteobacteria,1XM34@135619|Oceanospirillales	135619|Oceanospirillales	S	Src homology 3 domains	-	-	-	-	-	-	-	-	-	-	-	-	SH3_2
k59_230144_1	1125973.JNLC01000001_gene46	8.45e-80	266.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria,3JUU3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	B12 binding domain	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_230144_2	1159870.KB907784_gene1834	2.11e-11	65.1	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2VICH@28216|Betaproteobacteria,3T24G@506|Alcaligenaceae	28216|Betaproteobacteria	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_877467_1	568768.CM001975_gene2814	1.49e-78	243.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1SYGG@1236|Gammaproteobacteria,2JCU8@204037|Dickeya	1236|Gammaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	garR	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008679,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	iNRG857_1313.NRG857_15520	NAD_binding_11,NAD_binding_2
k59_1754947_1	367299.JOEE01000004_gene1042	6.14e-95	289.0	COG1304@1|root,COG1304@2|Bacteria,2GJA5@201174|Actinobacteria,4FFAY@85021|Intrasporangiaceae	201174|Actinobacteria	C	COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid	-	-	1.1.2.3,1.13.12.4	ko:K00101,ko:K00467	ko00620,ko01100,map00620,map01100	-	R00196,R00319	RC00044,RC01312	ko00000,ko00001,ko01000	-	-	-	FMN_dh
k59_1638038_1	335543.Sfum_2756	6.83e-73	240.0	COG0707@1|root,COG1413@1|root,COG0707@2|Bacteria,COG1413@2|Bacteria,1MVIB@1224|Proteobacteria,42ME1@68525|delta/epsilon subdivisions,2WJNY@28221|Deltaproteobacteria,2MRPC@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_1229133_1	1049564.TevJSym_aa01840	3.55e-137	400.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4G2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	zraR	GO:0000156,GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0023052,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035556,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_761306_1	748247.AZKH_1501	2.26e-96	301.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,2KVAY@206389|Rhodocyclales	28216|Betaproteobacteria	O	Heat shock 70 kDa protein	-	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_640906_1	1283300.ATXB01000002_gene2734	3.17e-31	130.0	COG2433@1|root,COG2433@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_465303_1	211165.AJLN01000093_gene1049	9.69e-128	388.0	COG0058@1|root,COG0058@2|Bacteria,1FZUX@1117|Cyanobacteria,1JKQ6@1189|Stigonemataceae	1117|Cyanobacteria	G	Carbohydrate phosphorylase	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_1582374_1	471853.Bcav_2200	9.64e-167	493.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1582374_2	653045.Strvi_7974	1.87e-53	177.0	COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria	201174|Actinobacteria	S	alcohol dehydrogenase	adhA	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1053467_1	590998.Celf_1259	3.43e-24	107.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4F0H0@85016|Cellulomonadaceae	201174|Actinobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
k59_174305_1	1208321.D104_16660	1.12e-13	70.1	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1XH6J@135619|Oceanospirillales	135619|Oceanospirillales	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.9	ko:K00611,ko:K09065	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_174305_2	317025.Tcr_0533	3.82e-23	99.4	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,4607E@72273|Thiotrichales	72273|Thiotrichales	E	PFAM aminotransferase class-III	argD	-	2.6.1.11,2.6.1.13,2.6.1.17	ko:K00819,ko:K00821	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00667,R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1405730_1	1502852.FG94_03062	4.53e-17	79.3	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,2VHZ0@28216|Betaproteobacteria,4731T@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_1405730_2	1528106.JRJE01000006_gene1093	2.84e-33	124.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2TS2D@28211|Alphaproteobacteria,2JQ4D@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
k59_349375_1	62928.azo2599	1.31e-49	160.0	COG0662@1|root,COG0662@2|Bacteria,1N40H@1224|Proteobacteria,2VWGU@28216|Betaproteobacteria,2KZHA@206389|Rhodocyclales	206389|Rhodocyclales	G	Auxin binding protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_349375_2	1408164.MOLA814_02717	2.16e-26	105.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2VIFE@28216|Betaproteobacteria,1KPNM@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_581987_1	582744.Msip34_0974	5.53e-30	117.0	COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,2VN9P@28216|Betaproteobacteria,2KKPC@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_879735_1	880072.Desac_0037	8.92e-81	248.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2WJ4U@28221|Deltaproteobacteria,2MQPY@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1360	Ldh_1_C,Ldh_1_N
k59_1231129_2	748658.KB907321_gene816	1.63e-18	90.9	2DECC@1|root,2ZMCQ@2|Bacteria	748658.KB907321_gene816|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1811563_1	471853.Bcav_1303	3.63e-28	107.0	COG0711@1|root,COG0711@2|Bacteria,2GJS4@201174|Actinobacteria	201174|Actinobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
k59_1811563_2	1713.JOFV01000002_gene492	2.01e-40	144.0	COG0712@1|root,COG0712@2|Bacteria,2GMJ5@201174|Actinobacteria,4F15E@85016|Cellulomonadaceae	201174|Actinobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02109,ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,OSCP
k59_1405749_1	589865.DaAHT2_1355	1.42e-25	103.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,42N9N@68525|delta/epsilon subdivisions,2WIY9@28221|Deltaproteobacteria,2MHVV@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ATP phosphoribosyltransferase	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
k59_1405749_2	675635.Psed_5861	5.87e-15	75.1	COG3158@1|root,COG3158@2|Bacteria,2GMPQ@201174|Actinobacteria,4E0FX@85010|Pseudonocardiales	201174|Actinobacteria	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_1405751_1	570967.JMLV01000003_gene2217	4.77e-102	305.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TS33@28211|Alphaproteobacteria,2JVK7@204441|Rhodospirillales	204441|Rhodospirillales	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
k59_1464952_1	1402135.SUH3_09030	3.68e-51	174.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,2TRXH@28211|Alphaproteobacteria,3ZVSM@60136|Sulfitobacter	28211|Alphaproteobacteria	M	Polysaccharide biosynthesis/export protein	bexD	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
k59_1701396_1	102232.GLO73106DRAFT_00029150	5.87e-33	124.0	2E3TX@1|root,32YRB@2|Bacteria,1GQPR@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_761386_1	90813.JQMT01000001_gene323	7.62e-41	149.0	COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RP1C@1236|Gammaproteobacteria,4606M@72273|Thiotrichales	72273|Thiotrichales	E	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
k59_761386_2	743722.Sph21_3158	4.7e-27	109.0	COG0069@1|root,COG0069@2|Bacteria,4NFKH@976|Bacteroidetes,1IREF@117747|Sphingobacteriia	976|Bacteroidetes	E	Belongs to the glutamate synthase family	glt	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
k59_640966_1	349124.Hhal_1056	9.14e-43	158.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales	135613|Chromatiales	E	glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1053563_1	204669.Acid345_0471	1.77e-42	160.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_701237_1	1026882.MAMP_02016	1.11e-191	556.0	COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,1RNMC@1236|Gammaproteobacteria,45ZS8@72273|Thiotrichales	72273|Thiotrichales	C	Belongs to the aconitase IPM isomerase family	-	-	4.2.1.3,4.2.1.99	ko:K01682	ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173	R01324,R01325,R01900,R04425	RC00497,RC00498,RC00618,RC01153	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_2_N,Aconitase_B_N
k59_582026_1	367299.JOEE01000001_gene1642	1.95e-64	204.0	COG0300@1|root,COG0300@2|Bacteria,2GKAJ@201174|Actinobacteria,4FI7N@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
k59_582026_2	367299.JOEE01000001_gene1641	9.3e-10	58.5	COG3173@1|root,COG3173@2|Bacteria,2GJT0@201174|Actinobacteria,4FFJV@85021|Intrasporangiaceae	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_761401_1	1126627.BAWE01000006_gene6806	5.15e-176	499.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,3JUYT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase, Mutator family	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_174373_1	28229.ND2E_3091	1.96e-15	70.1	2E3QA@1|root,32YN8@2|Bacteria,1N98P@1224|Proteobacteria,1SCNQ@1236|Gammaproteobacteria,2Q7AG@267889|Colwelliaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4266)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4266
k59_174373_2	1415780.JPOG01000001_gene3225	7.92e-23	99.8	COG2067@1|root,COG2067@2|Bacteria,1PXPC@1224|Proteobacteria,1RQKS@1236|Gammaproteobacteria,1X2X6@135614|Xanthomonadales	135614|Xanthomonadales	I	Protein of unknown function (DUF3570)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3570
k59_465409_1	1249627.D779_4143	5.11e-41	139.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,1S5VA@1236|Gammaproteobacteria,1WXYI@135613|Chromatiales	135613|Chromatiales	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
k59_465409_2	1249627.D779_4142	4.27e-34	130.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1WWM9@135613|Chromatiales	135613|Chromatiales	O	Cytochrome c-type biogenesis protein	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_1231174_1	521674.Plim_2184	7.33e-07	54.7	COG2010@1|root,COG2010@2|Bacteria,2IYHH@203682|Planctomycetes	203682|Planctomycetes	C	PFAM Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1
k59_1464969_1	1132441.KI519454_gene1035	3.71e-22	100.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria	201174|Actinobacteria	G	hydrolase, family 3	bglK	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
k59_1056038_1	367299.JOEE01000008_gene610	9.27e-33	122.0	COG2378@1|root,COG2378@2|Bacteria,2GM46@201174|Actinobacteria,4FFEG@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	pafB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K13572,ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
k59_1056038_2	367299.JOEE01000008_gene611	4.6e-33	124.0	COG3502@1|root,COG3502@2|Bacteria,2H2JJ@201174|Actinobacteria,4FETG@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3866)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3866
k59_467686_1	640081.Dsui_1011	1.6e-35	138.0	COG3452@1|root,COG5001@1|root,COG3452@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KVWQ@206389|Rhodocyclales	206389|Rhodocyclales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GGDEF,PAS_4
k59_702984_1	314230.DSM3645_17110	0.00042	48.5	COG1716@1|root,COG1716@2|Bacteria,2J0SY@203682|Planctomycetes	203682|Planctomycetes	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
k59_1758378_1	768671.ThimaDRAFT_3397	3.78e-42	140.0	2E0WU@1|root,32VAZ@2|Bacteria,1N42K@1224|Proteobacteria,1S97C@1236|Gammaproteobacteria,1X0UY@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_234018_1	483219.LILAB_00960	1.23e-33	131.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,4360M@68525|delta/epsilon subdivisions,2X2HZ@28221|Deltaproteobacteria,2Z0WC@29|Myxococcales	28221|Deltaproteobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_351337_1	2340.JV46_15380	4.63e-12	66.2	28KIA@1|root,2ZA3I@2|Bacteria,1MXIF@1224|Proteobacteria,1RMA6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	dsrS	-	-	-	-	-	-	-	-	-	-	-	-
k59_351337_2	314278.NB231_10663	2.61e-11	65.1	COG1018@1|root,COG1018@2|Bacteria,1MY2Q@1224|Proteobacteria,1RQZ8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1	paaE	GO:0000166,GO:0003674,GO:0005488,GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0036094,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051536,GO:0051537,GO:0051540,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0097159,GO:0098754,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	-	ko:K02613	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	iEcHS_1320.EcHS_A1479	FAD_binding_6,Fer2,NAD_binding_1
k59_234022_1	471852.Tcur_0407	2.45e-08	59.3	COG0664@1|root,COG0664@2|Bacteria,2GQ2Y@201174|Actinobacteria	201174|Actinobacteria	K	Crp-like helix-turn-helix domain	-	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_583345_1	1121935.AQXX01000090_gene3841	4.09e-21	98.2	COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XHII@135619|Oceanospirillales	135619|Oceanospirillales	T	Diguanylate cyclase phosphodiesterase with PAS PAC	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,EAL,GGDEF,PAS_9
k59_1813835_1	1123400.KB904816_gene1645	2.3e-33	127.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,4600C@72273|Thiotrichales	72273|Thiotrichales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_1813835_2	666685.R2APBS1_2291	7.78e-63	200.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1X45V@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the KdsA family	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
k59_351358_1	1121440.AUMA01000023_gene2046	1.69e-33	134.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,43CDW@68525|delta/epsilon subdivisions,2X7X2@28221|Deltaproteobacteria,2MHFY@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
k59_1813846_1	570268.ANBB01000002_gene299	5.38e-11	66.6	COG1595@1|root,COG1595@2|Bacteria,2GM5V@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
k59_703009_2	2340.JV46_15500	1.55e-84	249.0	COG1553@1|root,COG1553@2|Bacteria,1N021@1224|Proteobacteria,1S99J@1236|Gammaproteobacteria,1J6HU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	conserved protein involved in intracellular sulfur reduction	tusD	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0019417,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055114,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360,GO:1902494,GO:1990228,GO:1990234	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
k59_703009_3	765912.Thimo_0146	2.1e-07	49.7	COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,1SD0S@1236|Gammaproteobacteria,1WY53@135613|Chromatiales	135613|Chromatiales	P	Belongs to the DsrF TusC family	dsrF	-	-	ko:K07236	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DrsE
k59_642687_1	765911.Thivi_3168	1.15e-26	113.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales	135613|Chromatiales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_1056119_1	439235.Dalk_1318	7.2e-50	163.0	COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,43BHF@68525|delta/epsilon subdivisions,2WQUJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_703012_1	314278.NB231_04125	7.15e-85	258.0	COG3751@1|root,COG3751@2|Bacteria,1RAJ8@1224|Proteobacteria,1S3II@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1407165_1	1280953.HOC_17030	2.67e-112	337.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1056122_1	977880.RALTA_A0686	2.86e-43	155.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,1K0EM@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1056122_2	498761.HM1_1438	1.36e-27	106.0	arCOG06631@1|root,32RY6@2|Bacteria,1V8RP@1239|Firmicutes,24MV5@186801|Clostridia	186801|Clostridia	S	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1056122_3	95619.PM1_0201310	3.58e-112	358.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_467768_1	765912.Thimo_3607	7.15e-34	129.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,1RPTG@1236|Gammaproteobacteria,1X07C@135613|Chromatiales	135613|Chromatiales	F	Pyrimidine nucleoside phosphorylase C-terminal domain	-	-	2.4.2.4	ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_transf_3,PYNP_C
k59_1167991_1	335543.Sfum_0784	6.82e-135	392.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,42Q11@68525|delta/epsilon subdivisions,2WKFK@28221|Deltaproteobacteria,2MR3C@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_703021_1	32049.SYNPCC7002_A0794	3.66e-60	204.0	COG0471@1|root,COG0471@2|Bacteria,1G0FA@1117|Cyanobacteria,1GYSS@1129|Synechococcus	1117|Cyanobacteria	P	sodium sulfate transporter, DASS family protein	citT	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_523636_1	1163617.SCD_n02222	1.78e-95	289.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2VM8B@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1583856_1	504832.OCAR_6389	1.55e-42	148.0	COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,2TQWY@28211|Alphaproteobacteria,3JTFH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	NnrU protein	nnrU	-	-	-	-	-	-	-	-	-	-	-	NnrU
k59_523639_2	472759.Nhal_2885	4.22e-16	72.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	natSF	-	2.3.1.102,2.3.1.128	ko:K03789,ko:K03790,ko:K03896	ko00310,ko01120,map00310,map01120	-	R03168	RC00004,RC00865	ko00000,ko00001,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_3
k59_1758430_1	1232683.ADIMK_0867	1.01e-112	353.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D9@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_234091_1	1121926.AXWO01000002_gene1371	2.3e-20	91.7	COG0451@1|root,COG0451@2|Bacteria,2GP24@201174|Actinobacteria	201174|Actinobacteria	M	Epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_351408_1	867903.ThesuDRAFT_01410	8.82e-62	202.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,3WCS7@538999|Clostridiales incertae sedis	186801|Clostridia	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1
k59_1758444_1	1121923.GPUN_1958	6.52e-84	269.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,4641A@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_1816995_2	1487953.JMKF01000025_gene2357	7.54e-108	315.0	COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria,1H72I@1150|Oscillatoriales	1117|Cyanobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_1643222_1	1121405.dsmv_3265	3.78e-87	270.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42N89@68525|delta/epsilon subdivisions,2WIUT@28221|Deltaproteobacteria,2MN57@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_526296_1	765914.ThisiDRAFT_2001	8.94e-113	343.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1WX7K@135613|Chromatiales	135613|Chromatiales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_812318_1	1211815.CBYP010000016_gene2617	5.7e-23	107.0	COG3266@1|root,COG3266@2|Bacteria,2I44K@201174|Actinobacteria,4ERQA@85013|Frankiales	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1760880_1	1267005.KB911259_gene3834	8.52e-122	360.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2TQQ1@28211|Alphaproteobacteria,3N67Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
k59_645466_1	1249627.D779_3094	1.4e-85	261.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria,1WXIF@135613|Chromatiales	135613|Chromatiales	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_585750_1	1049564.TevJSym_ap00720	6.71e-88	286.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1J5E8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Carbamoyl-phosphate synthetase ammonia chain	carB	GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041	CPSase_L_D2,CPSase_L_D3,MGS
k59_645478_1	391008.Smal_2644	1.54e-08	53.1	2ANYG@1|root,31DZF@2|Bacteria,1QB9H@1224|Proteobacteria,1T6TX@1236|Gammaproteobacteria,1X857@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1760932_1	1051646.VITU9109_08602	2.78e-31	125.0	28K8V@1|root,2Z9WK@2|Bacteria,1R70Q@1224|Proteobacteria,1SM63@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PhoD
k59_645511_1	1120977.JHUX01000003_gene658	7.19e-83	256.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,3NIXJ@468|Moraxellaceae	1236|Gammaproteobacteria	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009014,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0032153,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0046872,GO:0046914,GO:0050897,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_2485	M20_dimer,Peptidase_M20
k59_526361_1	1454004.AW11_02478	2.95e-20	86.3	2EE2B@1|root,337X1@2|Bacteria,1N433@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1643302_1	1173024.KI912153_gene217	6.46e-43	152.0	COG0167@1|root,COG0167@2|Bacteria,1G2B6@1117|Cyanobacteria,1JKMZ@1189|Stigonemataceae	1117|Cyanobacteria	F	Dihydroorotate dehydrogenase	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_1817068_1	1380367.JIBC01000003_gene3934	4.33e-07	52.8	COG1171@1|root,COG1171@2|Bacteria,1QVNS@1224|Proteobacteria,2TUHW@28211|Alphaproteobacteria,3ZW4R@60136|Sulfitobacter	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	dpaL	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008838,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575	4.3.1.15	ko:K01751	-	-	-	-	ko00000,ko01000	-	-	-	PALP
k59_1817068_2	221288.JH992901_gene4659	3.51e-06	52.4	COG3967@1|root,COG3967@2|Bacteria,1G8SW@1117|Cyanobacteria	1117|Cyanobacteria	M	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K08151,ko:K14189	-	M00668	-	-	ko00000,ko00002,ko01000,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75	-	-	adh_short
k59_585813_1	1237149.C900_04762	1.31e-06	55.5	COG2843@1|root,COG2843@2|Bacteria,4NI9W@976|Bacteroidetes,47RV2@768503|Cytophagia	976|Bacteroidetes	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
k59_526380_1	1354722.JQLS01000008_gene2833	8.87e-36	135.0	COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2TR1Z@28211|Alphaproteobacteria,46QMS@74030|Roseovarius	28211|Alphaproteobacteria	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system	modC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
k59_526380_2	396588.Tgr7_2682	4.92e-35	129.0	COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,1S6FG@1236|Gammaproteobacteria,1WY34@135613|Chromatiales	135613|Chromatiales	S	pfam ammecr1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
k59_526380_3	1454004.AW11_01260	1.89e-54	180.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,2VKXP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
k59_1643314_1	1123073.KB899242_gene1477	2.68e-53	173.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1X35D@135614|Xanthomonadales	135614|Xanthomonadales	S	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_1643314_2	243233.MCA1561	1.86e-102	308.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1XG63@135618|Methylococcales	135618|Methylococcales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1760966_1	95619.PM1_0200120	1.39e-90	283.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_585821_1	631362.Thi970DRAFT_02788	8.57e-57	194.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1WWE3@135613|Chromatiales	135613|Chromatiales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_585821_2	396588.Tgr7_1565	5.13e-56	180.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,1WY89@135613|Chromatiales	135613|Chromatiales	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	-	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
k59_585821_3	549.BW31_00124	1.08e-12	70.1	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,3VZYC@53335|Pantoea	1236|Gammaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iSFV_1184.SFV_0382	AIRS,AIRS_C
k59_1760967_2	1249627.D779_2939	1.98e-54	186.0	COG1527@1|root,COG1527@2|Bacteria,1R7PV@1224|Proteobacteria,1S0C2@1236|Gammaproteobacteria,1WWZK@135613|Chromatiales	135613|Chromatiales	C	(C AC39) subunit	-	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
k59_585825_1	439235.Dalk_3879	1.4e-97	304.0	COG5421@1|root,COG5421@2|Bacteria,1R7NE@1224|Proteobacteria,42M25@68525|delta/epsilon subdivisions,2WKHV@28221|Deltaproteobacteria,2MJVY@213118|Desulfobacterales	28221|Deltaproteobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_585863_1	446466.Cfla_3708	6.69e-93	288.0	COG0477@1|root,COG0477@2|Bacteria,2I2KV@201174|Actinobacteria,4F0MW@85016|Cellulomonadaceae	201174|Actinobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_812440_1	367299.JOEE01000011_gene3137	2.2e-69	223.0	COG2223@1|root,COG2223@2|Bacteria,2I4E5@201174|Actinobacteria,4FK03@85021|Intrasporangiaceae	201174|Actinobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1643379_1	909943.HIMB100_00016620	3.87e-87	266.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TSIY@28211|Alphaproteobacteria,4BQ25@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EP	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_585882_1	880072.Desac_1145	7.8e-86	279.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_526463_1	717231.Flexsi_0321	9.16e-27	102.0	COG2905@1|root,COG2905@2|Bacteria,2GGGX@200930|Deferribacteres	200930|Deferribacteres	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_585889_1	1121875.KB907546_gene2238	8.31e-14	72.0	COG1409@1|root,COG1409@2|Bacteria,4NFAP@976|Bacteroidetes,1I2DE@117743|Flavobacteriia	976|Bacteroidetes	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,PA14
k59_585889_2	498211.CJA_3662	2.62e-06	48.9	COG3637@1|root,COG3637@2|Bacteria,1RHVI@1224|Proteobacteria,1S6UY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	OmpA-like transmembrane domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,OmpA_membrane
k59_1171554_1	269798.CHU_0855	5.96e-08	58.9	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	tehB	-	2.1.1.265	ko:K16868	-	-	-	-	ko00000,ko01000	-	-	-	DUF1971,DUF4062,MerR_1,Methyltransf_11,Methyltransf_31,Sulfotransfer_2,TehB
k59_526472_1	414684.RC1_1820	3.1e-50	181.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,2TUXY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EU	peptidase S9	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_585899_2	523791.Kkor_2053	3.19e-76	241.0	COG0591@1|root,COG0591@2|Bacteria,1N8H2@1224|Proteobacteria,1RR54@1236|Gammaproteobacteria,1XMCT@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_1643400_3	1434929.X946_26	5.72e-12	66.2	COG3509@1|root,COG3509@2|Bacteria,1NTIV@1224|Proteobacteria,2VKDX@28216|Betaproteobacteria,1K7GS@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	depolymerase	-	-	3.1.1.75	ko:K05973	ko00650,map00650	-	R05118	-	ko00000,ko00001,ko01000	-	-	-	Esterase_phd
k59_1761077_1	1035308.AQYY01000002_gene365	5.92e-123	363.0	COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,2618F@186807|Peptococcaceae	186801|Clostridia	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_1643417_2	713586.KB900536_gene132	1.82e-14	73.2	COG2825@1|root,COG2825@2|Bacteria,1NBEV@1224|Proteobacteria,1SDHN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Outer membrane protein (OmpH-like)	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
k59_645723_1	56780.SYN_02874	1.53e-86	264.0	COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,42M1U@68525|delta/epsilon subdivisions,2WKK5@28221|Deltaproteobacteria,2MRYB@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	pfkB family carbohydrate kinase	-	-	2.7.1.15,2.7.1.4	ko:K00847,ko:K00852	ko00030,ko00051,ko00500,ko00520,ko01100,map00030,map00051,map00500,map00520,map01100	-	R00760,R00867,R01051,R02750,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_645728_1	1095767.CAHD01000194_gene214	1.07e-74	251.0	COG1033@1|root,COG2409@1|root,COG1033@2|Bacteria,COG2409@2|Bacteria,2GIRQ@201174|Actinobacteria,4F0TE@85016|Cellulomonadaceae	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
k59_812530_2	471853.Bcav_3530	2.4e-113	342.0	COG1027@1|root,COG1027@2|Bacteria,2I2HG@201174|Actinobacteria	201174|Actinobacteria	E	Aspartate ammonia-lyase	aspA	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_1171649_1	1255043.TVNIR_3739	1.33e-46	156.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1RSPA@1236|Gammaproteobacteria,1WXV0@135613|Chromatiales	135613|Chromatiales	S	Cytokinin riboside 5'-monophosphate phosphoribohydrolase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_1819982_1	748658.KB907316_gene445	1.31e-16	76.6	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S6RN@1236|Gammaproteobacteria,1X27A@135613|Chromatiales	135613|Chromatiales	K	MraZ protein, putative antitoxin-like	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
k59_1819982_2	287.DR97_1598	1.03e-48	166.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1YE1H@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_1350302_1	158190.SpiGrapes_1857	3.13e-61	212.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1143@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1143@2|Bacteria,2J5QV@203691|Spirochaetes	203691|Spirochaetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_939417_1	1248917.ANFX01000037_gene2175	8.8e-27	109.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2TRVJ@28211|Alphaproteobacteria,2JZUZ@204457|Sphingomonadales	204457|Sphingomonadales	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_939417_2	1255043.TVNIR_0254	1.36e-25	105.0	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	ko:K09384	-	-	-	-	ko00000	-	-	-	Abhydrolase_8,PGAP1
k59_176206_1	887898.HMPREF0551_2142	1.35e-127	391.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,1K0Y7@119060|Burkholderiaceae	28216|Betaproteobacteria	L	dna topoisomerase III	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	SWIB,Topoisom_bac,Toprim,Toprim_Crpt
k59_1585117_1	1120792.JAFV01000001_gene1966	7.42e-43	149.0	COG0702@1|root,COG0702@2|Bacteria,1MZG7@1224|Proteobacteria,2UBX1@28211|Alphaproteobacteria,370XR@31993|Methylocystaceae	28211|Alphaproteobacteria	GM	Nucleoside-diphosphate-sugar epimerases	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
k59_1585117_2	1031711.RSPO_c00651	9.79e-49	171.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,1K4G7@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_1056789_1	441620.Mpop_2368	2.98e-49	181.0	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,1JS5X@119045|Methylobacteriaceae	28211|Alphaproteobacteria	QU	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
k59_1115486_1	367299.JOEE01000002_gene2472	1.2e-75	234.0	COG0584@1|root,COG0584@2|Bacteria,2GMMS@201174|Actinobacteria,4FF8N@85021|Intrasporangiaceae	201174|Actinobacteria	C	Glycerophosphoryl diester phosphodiesterase family	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_1702537_1	864073.HFRIS_008646	2.14e-55	194.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2VIBW@28216|Betaproteobacteria,473EF@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_352369_1	1341646.CBMO010000033_gene5288	1.41e-113	341.0	COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,237CI@1762|Mycobacteriaceae	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_352369_2	446471.Xcel_1993	2.64e-14	77.8	2AR9G@1|root,31GJC@2|Bacteria,2I0KT@201174|Actinobacteria,4F4KM@85017|Promicromonosporaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4192)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4192
k59_1115492_2	497964.CfE428DRAFT_4444	2.22e-18	79.7	28X6Y@1|root,2ZJ59@2|Bacteria,46WIZ@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1761244_1	1045855.DSC_01005	7.58e-39	144.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1X51M@135614|Xanthomonadales	135614|Xanthomonadales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_1761244_2	935863.AWZR01000001_gene1780	1.68e-24	102.0	COG4648@1|root,COG4648@2|Bacteria,1NCP1@1224|Proteobacteria,1SEHE@1236|Gammaproteobacteria,1X683@135614|Xanthomonadales	135614|Xanthomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_763275_1	640081.Dsui_1550	8.46e-27	115.0	COG0745@1|root,COG5001@1|root,COG0745@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VMI4@28216|Betaproteobacteria,2KW0C@206389|Rhodocyclales	206389|Rhodocyclales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,Response_reg
k59_763275_2	1123392.AQWL01000003_gene189	1.02e-58	194.0	COG1152@1|root,COG1152@2|Bacteria,1QX31@1224|Proteobacteria,2VQW1@28216|Betaproteobacteria,1KRZ6@119069|Hydrogenophilales	119069|Hydrogenophilales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
k59_1409017_1	748247.AZKH_1502	4.57e-42	148.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,2KUWF@206389|Rhodocyclales	28216|Betaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_117521_1	29581.BW37_01512	1.68e-18	83.2	COG3201@1|root,COG3201@2|Bacteria,1MXN4@1224|Proteobacteria,2VRT2@28216|Betaproteobacteria,47483@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Nicotinamide mononucleotide transporter	pnuC	-	-	ko:K03811	-	-	-	-	ko00000,ko02000	4.B.1.1	-	-	NMN_transporter
k59_939455_1	1499967.BAYZ01000074_gene2123	3.31e-65	213.0	COG0438@1|root,COG0438@2|Bacteria,2NQHY@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1,Glycos_transf_2
k59_645882_1	1283300.ATXB01000001_gene1369	1.82e-40	149.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1XDW7@135618|Methylococcales	135618|Methylococcales	S	Permease YjgP YjgQ	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_939457_2	1123399.AQVE01000019_gene1569	1.28e-10	59.7	2EG5Z@1|root,339XV@2|Bacteria,1NN9Y@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1643865_1	754252.PFREUD_11970	5.92e-15	74.7	COG4120@1|root,COG4120@2|Bacteria,2I8VW@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K05832	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	BPD_transp_2
k59_59542_1	572477.Alvin_1639	8.55e-32	113.0	2DPGF@1|root,331YU@2|Bacteria,1N6ZX@1224|Proteobacteria,1SDQJ@1236|Gammaproteobacteria,1WZ1Q@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_59542_2	765912.Thimo_2743	9.18e-09	54.7	28NV7@1|root,2ZBTD@2|Bacteria,1RAH4@1224|Proteobacteria,1S2YP@1236|Gammaproteobacteria,1WY67@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1292339_1	933262.AXAM01000004_gene2356	2.79e-104	330.0	COG0574@1|root,COG0745@1|root,COG0574@2|Bacteria,COG0745@2|Bacteria,1N38V@1224|Proteobacteria,42MWC@68525|delta/epsilon subdivisions,2WKAZ@28221|Deltaproteobacteria,2MICZ@213118|Desulfobacterales	28221|Deltaproteobacteria	GT	pyruvate phosphate dikinase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2,PPDK_N
k59_1820699_1	1211115.ALIQ01000131_gene1728	6.9e-66	225.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,3NAR6@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Cation transport ATPase (P-type)	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_1115873_1	582899.Hden_0416	6.94e-70	233.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2TR7V@28211|Alphaproteobacteria,3N6HF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DEAD/H associated	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_1585446_1	590998.Celf_0569	1.33e-41	153.0	COG3428@1|root,COG3428@2|Bacteria,2GJCD@201174|Actinobacteria,4F13S@85016|Cellulomonadaceae	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
k59_1468103_1	314285.KT71_03017	4.08e-89	290.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1RWT6@1236|Gammaproteobacteria,1J7Y7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1292351_1	1385935.N836_11090	2.22e-41	149.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1292355_1	883080.HMPREF9697_02241	2.39e-73	238.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,3JU1V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	PHBC_N,PhaC_N
k59_235386_1	927658.AJUM01000016_gene3146	2.65e-09	60.8	COG2356@1|root,COG2356@2|Bacteria,4NEGS@976|Bacteroidetes,2FPB5@200643|Bacteroidia,3XJ1B@558415|Marinilabiliaceae	976|Bacteroidetes	L	Endonuclease I	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_1,LTD,fn3
k59_1820724_1	396588.Tgr7_0567	1.78e-81	264.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_940183_1	864073.HFRIS_024147	1.56e-71	226.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,2VI9A@28216|Betaproteobacteria,4730X@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
k59_59585_1	795666.MW7_2642	5.25e-76	252.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,1K1R9@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_117912_2	1082931.KKY_3695	3.65e-59	198.0	COG0527@1|root,COG0527@2|Bacteria,1MVSI@1224|Proteobacteria,2TQQF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7
k59_940186_1	1041147.AUFB01000050_gene4052	4.87e-90	277.0	COG3385@1|root,COG3385@2|Bacteria,1PHKQ@1224|Proteobacteria,2VGVZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_940187_1	1172188.KB911823_gene432	2.76e-51	175.0	COG0642@1|root,COG2205@2|Bacteria,2I3JI@201174|Actinobacteria,4FGKJ@85021|Intrasporangiaceae	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_470085_1	395493.BegalDRAFT_0765	2.19e-129	374.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,45ZWH@72273|Thiotrichales	72273|Thiotrichales	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_998559_1	1125863.JAFN01000001_gene3126	4.31e-79	252.0	COG5659@1|root,COG5659@2|Bacteria,1MWAV@1224|Proteobacteria,43BD6@68525|delta/epsilon subdivisions,2X6S2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_1409378_1	572477.Alvin_0412	7.49e-110	327.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,1WWQK@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_353123_1	84531.JMTZ01000019_gene4018	5.83e-77	241.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,1X4BJ@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_1233315_1	1249627.D779_0167	8.18e-17	80.5	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,LysM
k59_1233315_2	1121923.GPUN_0142	4.87e-90	279.0	COG0589@1|root,COG0589@2|Bacteria,1RCWK@1224|Proteobacteria,1S4TR@1236|Gammaproteobacteria,466X8@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1233315_3	296591.Bpro_3393	4.57e-20	92.8	COG0204@1|root,COG0236@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0236@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,4AB3C@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,Acyltransferase,PP-binding
k59_822431_1	1120949.KB903300_gene6157	5.06e-25	107.0	COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria,4DD18@85008|Micromonosporales	201174|Actinobacteria	L	required for the transposition of insertion element IS2404	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_1820749_1	935261.JAGL01000001_gene1555	2.23e-69	233.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2TS8V@28211|Alphaproteobacteria,43J49@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component	MA20_43810	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_293984_1	1026882.MAMP_03002	4.53e-54	184.0	COG1538@1|root,COG1538@2|Bacteria,1MYX2@1224|Proteobacteria,1RNX1@1236|Gammaproteobacteria,4608N@72273|Thiotrichales	72273|Thiotrichales	MU	TIGRFAM type I secretion outer membrane protein, TolC family	-	-	-	ko:K12543	-	M00330	-	-	ko00000,ko00002,ko02000,ko02044	1.B.17,3.A.1.109.4	-	-	OEP
k59_1644288_1	478741.JAFS01000001_gene1273	9.27e-19	86.7	COG4992@1|root,COG4992@2|Bacteria,46UBT@74201|Verrucomicrobia,37FZC@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	E	Aminotransferase class-III	-	-	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_1644288_2	1333998.M2A_2326	5.05e-21	89.0	COG1695@1|root,COG1695@2|Bacteria,1N33P@1224|Proteobacteria,2U9ZC@28211|Alphaproteobacteria,4BSCC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_881539_2	479431.Namu_3445	9.71e-95	286.0	COG3001@1|root,COG3001@2|Bacteria,2GW7W@201174|Actinobacteria	201174|Actinobacteria	G	Fructosamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Fructosamin_kin
k59_235409_1	713586.KB900536_gene1806	1.02e-119	355.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1WWVW@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM cytochrome c oxidase accessory protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
k59_1292398_1	265072.Mfla_1839	1.83e-86	280.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,2KKPG@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Domain of unknown function (DUF3488)	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
k59_470095_1	911045.PSE_3738	6.13e-10	55.8	29ZH6@1|root,30MGX@2|Bacteria,1Q4G5@1224|Proteobacteria,2UN38@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1656)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1656
k59_470095_2	911045.PSE_3739	3.57e-82	261.0	COG1566@1|root,COG1566@2|Bacteria,1MWG0@1224|Proteobacteria,2TRI4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_1174605_1	1121912.AUHD01000010_gene3657	3.44e-14	75.1	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,4NGF6@976|Bacteroidetes,1HXGN@117743|Flavobacteriia	976|Bacteroidetes	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
k59_822439_1	382464.ABSI01000006_gene815	1.3e-24	109.0	COG0771@1|root,COG2911@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,46UDY@74201|Verrucomicrobia,2IWGN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	Q	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_470098_2	338966.Ppro_2750	1.2e-07	54.7	COG1132@1|root,COG1132@2|Bacteria,1MVJD@1224|Proteobacteria,42PP5@68525|delta/epsilon subdivisions,2WNMV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM ABC transporter	-	-	-	ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1	-	-	ABC_membrane,ABC_tran
k59_59632_1	765912.Thimo_2267	2.64e-11	61.6	COG0636@1|root,COG0636@2|Bacteria,1N5D3@1224|Proteobacteria,1SBV1@1236|Gammaproteobacteria,1WZ48@135613|Chromatiales	135613|Chromatiales	U	Belongs to the V-ATPase proteolipid subunit family	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
k59_59632_2	768671.ThimaDRAFT_4701	1.38e-34	131.0	COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria,1WX8D@135613|Chromatiales	135613|Chromatiales	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_1174606_1	593907.Celgi_0315	2.07e-138	413.0	COG0596@1|root,COG0596@2|Bacteria,2GJYS@201174|Actinobacteria,4F0SR@85016|Cellulomonadaceae	201174|Actinobacteria	S	TAP-like protein	slpD	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
k59_1820777_1	357808.RoseRS_0631	2.11e-84	254.0	COG3335@1|root,COG3335@2|Bacteria,2G8GI@200795|Chloroflexi	200795|Chloroflexi	L	SPTR Q2LSA8 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_1233336_2	713587.THITH_16445	2.94e-10	62.8	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1WVY3@135613|Chromatiales	135613|Chromatiales	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1702959_1	861360.AARI_29190	1.55e-26	110.0	COG3949@1|root,COG3949@2|Bacteria,2IEGE@201174|Actinobacteria,1W8WS@1268|Micrococcaceae	201174|Actinobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_59655_1	1267535.KB906767_gene2784	8.92e-50	179.0	COG3387@1|root,COG3387@2|Bacteria,3Y3QW@57723|Acidobacteria,2JIEZ@204432|Acidobacteriia	204432|Acidobacteriia	G	Domain of unknown function (DUF5127)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1793,DUF4964,DUF4965,DUF5127
k59_881587_1	1111728.ATYS01000009_gene484	3.4e-46	159.0	COG1606@1|root,COG1606@2|Bacteria,1R7UZ@1224|Proteobacteria,1S200@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TIGRFAM TIGR00268 family protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
k59_1644324_1	748247.AZKH_3043	4.96e-24	101.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VHW2@28216|Betaproteobacteria,2KUYG@206389|Rhodocyclales	206389|Rhodocyclales	C	Respiratory-chain NADH dehydrogenase	hoxF	-	1.12.1.2	ko:K18005	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_1585501_2	570967.JMLV01000008_gene1311	3.29e-23	92.0	COG0633@1|root,COG0633@2|Bacteria,1N261@1224|Proteobacteria,2UC7B@28211|Alphaproteobacteria,2JU4G@204441|Rhodospirillales	204441|Rhodospirillales	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
k59_235438_1	765912.Thimo_1328	5.92e-37	130.0	COG2840@1|root,COG2840@2|Bacteria,1MVS6@1224|Proteobacteria,1RPXD@1236|Gammaproteobacteria,1X2FW@135613|Chromatiales	135613|Chromatiales	S	PFAM Smr	-	-	-	-	-	-	-	-	-	-	-	-	Smr
k59_235438_2	1120953.AUBH01000006_gene2657	1.2e-23	100.0	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,465C2@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
k59_1350741_1	1304275.C41B8_12504	2.14e-96	298.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010876,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0030203,GO:0031224,GO:0031226,GO:0033036,GO:0034203,GO:0034204,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097035,GO:1901135,GO:1901137,GO:1901264,GO:1901505,GO:1901564,GO:1901566,GO:1901576	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	iECO103_1326.ECO103_1114	MVIN
k59_1057300_1	243231.GSU2415	1.4e-73	229.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,42SUC@68525|delta/epsilon subdivisions,2WPR4@28221|Deltaproteobacteria,43V8Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
k59_747_1	768671.ThimaDRAFT_3547	6.54e-78	249.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,1S124@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	BT1 family	-	-	-	-	-	-	-	-	-	-	-	-	BT1
k59_1702968_1	1193181.BN10_1380002	5.56e-113	345.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4FF7R@85021|Intrasporangiaceae	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_705022_1	3847.GLYMA13G11980.1	6.08e-78	259.0	2CUMQ@1|root,2RN4M@2759|Eukaryota,37U2D@33090|Viridiplantae,3GX5D@35493|Streptophyta,4JTXP@91835|fabids	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1820824_1	653733.Selin_1983	6.02e-87	272.0	COG1894@1|root,COG1894@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	hoxF	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K05587,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_235446_1	396588.Tgr7_0300	2.06e-99	309.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1WWYZ@135613|Chromatiales	135613|Chromatiales	E	PFAM Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_941857_1	593907.Celgi_2089	7.94e-39	144.0	COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4F1WF@85016|Cellulomonadaceae	201174|Actinobacteria	M	Peptidase family M50	rip1	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
k59_647337_1	1121116.KB894766_gene276	3.6e-85	257.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2VHMC@28216|Betaproteobacteria,4AA42@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM beta-lactamase domain protein	ycbL	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_647337_2	1158150.KB906247_gene2353	7.94e-33	122.0	COG2928@1|root,COG2928@2|Bacteria,1R79M@1224|Proteobacteria,1S6CC@1236|Gammaproteobacteria,1WZFF@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
k59_177653_1	349521.HCH_00541	1.38e-40	158.0	COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1XHMP@135619|Oceanospirillales	135619|Oceanospirillales	T	Chemotaxis protein histidine kinase and related	chpA	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_883157_1	1121438.JNJA01000006_gene309	2.29e-141	407.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,42MTN@68525|delta/epsilon subdivisions,2WJAI@28221|Deltaproteobacteria,2M8UU@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rmlA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_1586407_1	1366046.HIMB11_00302	3.17e-51	173.0	COG0346@1|root,COG0346@2|Bacteria,1MUWY@1224|Proteobacteria,2TTMJ@28211|Alphaproteobacteria,3ZH4C@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	H	3,4-dihydroxyphenylacetate 2,3-dioxygenase'	hpaD	-	1.13.11.2	ko:K00446	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
k59_1527726_1	506534.Rhein_1214	8.43e-88	281.0	COG2234@1|root,COG2234@2|Bacteria,1MUZ7@1224|Proteobacteria,1RS0Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_588622_1	454957.IA64_03840	2.73e-37	133.0	COG0251@1|root,COG0251@2|Bacteria,1RD3E@1224|Proteobacteria,1S6NI@1236|Gammaproteobacteria,1X6JQ@135614|Xanthomonadales	135614|Xanthomonadales	J	translation initiation inhibitor, yjgF family	tdcF	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_354737_1	1193181.BN10_1320004	4.98e-36	132.0	COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria,4FEQQ@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the synthesis of xanthosine monophosphate by the NAD dependent oxidation of inosine monophosphate	guaB3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	IMPDH
k59_354737_2	67281.JNZZ01000019_gene156	1.15e-07	54.7	COG1012@1|root,COG1012@2|Bacteria,2GJ95@201174|Actinobacteria,41AB3@629295|Streptomyces griseus group	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1294046_1	935839.JAGJ01000012_gene2938	1.25e-185	527.0	COG0683@1|root,COG0683@2|Bacteria,2GM00@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Extracellular ligand-binding receptor	braC	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_119023_2	187272.Mlg_1819	1.85e-86	274.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1WW9D@135613|Chromatiales	135613|Chromatiales	L	single-stranded-DNA-specific exonuclease RecJ	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_1351739_1	439235.Dalk_2957	5.39e-61	196.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,42T4F@68525|delta/epsilon subdivisions,2WP6B@28221|Deltaproteobacteria,2MJST@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
k59_883180_1	1163617.SCD_n00406	5.91e-14	70.9	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2VJ6W@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_883180_2	1049564.TevJSym_bd00190	6.64e-101	300.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,1RPKN@1236|Gammaproteobacteria,1JBV7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulatory protein, C terminal	ompR	GO:0000156,GO:0000160,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0035556,GO:0043565,GO:0044212,GO:0044424,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1469186_1	880072.Desac_2388	1.15e-96	294.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MRH1@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_883183_1	1206729.BAFZ01000113_gene366	6.05e-111	333.0	COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria,4FWJS@85025|Nocardiaceae	201174|Actinobacteria	C	Elongator protein 3, MiaB family, Radical SAM	pqqE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_354754_1	497964.CfE428DRAFT_2906	5.76e-42	144.0	COG0052@1|root,COG0052@2|Bacteria,46SNG@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_765396_1	1267005.KB911255_gene2472	8.56e-92	283.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2TS41@28211|Alphaproteobacteria,3N637@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_413291_1	89187.ISM_03805	1.19e-132	383.0	COG1176@1|root,COG1176@2|Bacteria,1MU1Y@1224|Proteobacteria,2TTJ6@28211|Alphaproteobacteria,46NV4@74030|Roseovarius	28211|Alphaproteobacteria	P	COG1176 ABC-type spermidine putrescine transport system, permease component I	-	-	-	ko:K02054,ko:K11071	ko02010,ko02024,map02010,map02024	M00193,M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.11.1	-	-	BPD_transp_1
k59_1000311_1	1123023.JIAI01000001_gene6156	4.06e-119	353.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4DZT6@85010|Pseudonocardiales	201174|Actinobacteria	I	Carboxyl transferase domain	yngE	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
k59_884485_1	1089552.KI911559_gene875	1.4e-15	74.3	COG1846@1|root,COG1846@2|Bacteria,1RIX7@1224|Proteobacteria,2U94M@28211|Alphaproteobacteria,2JS8Q@204441|Rhodospirillales	204441|Rhodospirillales	K	transcriptional	petP	-	-	-	-	-	-	-	-	-	-	-	MarR_2
k59_884485_2	1380391.JIAS01000012_gene4285	6.92e-25	99.4	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TSQF@28211|Alphaproteobacteria,2JRP8@204441|Rhodospirillales	204441|Rhodospirillales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	ompR	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_178616_1	1333998.M2A_0169	3.35e-51	173.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ammonium transporter'	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_356098_1	240016.ABIZ01000001_gene1220	2.36e-10	70.5	COG2706@1|root,COG2931@1|root,COG3210@1|root,COG3291@1|root,COG4932@1|root,COG2706@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG4932@2|Bacteria,46XPA@74201|Verrucomicrobia,2IWB2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	MQ	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1823639_1	1177179.A11A3_08515	6.18e-13	70.5	COG2114@1|root,COG5000@1|root,COG2114@2|Bacteria,COG5000@2|Bacteria,1MV1V@1224|Proteobacteria,1SZ0N@1236|Gammaproteobacteria,1XMTD@135619|Oceanospirillales	135619|Oceanospirillales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
k59_1235352_1	580332.Slit_0533	3.18e-13	70.5	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_884494_1	941449.dsx2_0363	5.95e-167	498.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2M9PX@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	iAF987.Gmet_1547	ACR_tran
k59_1528663_1	717785.HYPMC_0053	4.62e-30	119.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2TSD9@28211|Alphaproteobacteria,3N8KT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	LysR substrate binding domain	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
k59_707046_1	1035308.AQYY01000002_gene748	8.92e-175	518.0	COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,247XX@186801|Clostridia,2606P@186807|Peptococcaceae	186801|Clostridia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_62614_1	1123257.AUFV01000009_gene2289	2.62e-36	131.0	COG2962@1|root,COG2962@2|Bacteria,1MX5G@1224|Proteobacteria,1RMAC@1236|Gammaproteobacteria,1X3PF@135614|Xanthomonadales	135614|Xanthomonadales	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_765413_1	243233.MCA2605	2.5e-55	186.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria,1XFWC@135618|Methylococcales	135618|Methylococcales	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	hDGE_amylase
k59_648259_1	1304865.JAGF01000001_gene2667	1.5e-10	65.5	COG1652@1|root,COG1652@2|Bacteria,2GWK7@201174|Actinobacteria	201174|Actinobacteria	NU	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_1411427_1	870187.Thini_2168	5.34e-170	488.0	COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,1RQEA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Iron-sulfur cluster binding protein	lutB	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
k59_1295427_2	1496688.ER33_12255	5.27e-48	160.0	COG3806@1|root,COG3806@2|Bacteria,1G0B3@1117|Cyanobacteria,22SCW@167375|Cyanobium	1117|Cyanobacteria	T	ChrR Cupin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
k59_119995_2	472759.Nhal_0095	8.39e-71	227.0	COG0297@1|root,COG0297@2|Bacteria,1P7F2@1224|Proteobacteria,1RZVJ@1236|Gammaproteobacteria,1WX4C@135613|Chromatiales	135613|Chromatiales	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	-	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_1235366_2	1205908.AKXW01000177_gene3035	3.67e-30	120.0	COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria,1S06C@1236|Gammaproteobacteria,1XUEX@135623|Vibrionales	135623|Vibrionales	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
k59_1411434_1	768671.ThimaDRAFT_1753	6.88e-67	207.0	COG1633@1|root,COG1633@2|Bacteria,1RDK1@1224|Proteobacteria,1S55F@1236|Gammaproteobacteria,1X1N3@135613|Chromatiales	135613|Chromatiales	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
k59_1059543_1	590998.Celf_2884	2.3e-41	152.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4F0PP@85016|Cellulomonadaceae	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_884533_1	1121288.AULL01000005_gene1918	1.83e-06	55.5	COG1649@1|root,COG1649@2|Bacteria,4NFKQ@976|Bacteroidetes,1HXFY@117743|Flavobacteriia,3ZNVT@59732|Chryseobacterium	976|Bacteroidetes	S	Glycosyl hydrolase-like 10	yngK	-	-	-	-	-	-	-	-	-	-	-	GHL10
k59_1295452_1	1121935.AQXX01000141_gene2069	1.15e-146	428.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1XH7E@135619|Oceanospirillales	135619|Oceanospirillales	S	ABC transporter ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
k59_1528690_1	9713.XP_006743179.1	9.7e-09	62.0	COG1028@1|root,KOG1201@2759|Eukaryota,38DUA@33154|Opisthokonta,3B9V8@33208|Metazoa,3CS2U@33213|Bilateria,485XD@7711|Chordata,490QG@7742|Vertebrata,3JBRP@40674|Mammalia,3ETTP@33554|Carnivora	33208|Metazoa	Q	Short chain dehydrogenase reductase family 16C, member 5	SDR16C5	GO:0000122,GO:0000988,GO:0000989,GO:0001076,GO:0001191,GO:0001523,GO:0003674,GO:0003824,GO:0004745,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0005811,GO:0006066,GO:0006081,GO:0006355,GO:0006357,GO:0006629,GO:0006720,GO:0006721,GO:0006950,GO:0008134,GO:0008150,GO:0008152,GO:0008283,GO:0009889,GO:0009890,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010604,GO:0010605,GO:0010629,GO:0010638,GO:0010639,GO:0010817,GO:0012505,GO:0016020,GO:0016101,GO:0016491,GO:0016614,GO:0016616,GO:0017053,GO:0019219,GO:0019222,GO:0031056,GO:0031057,GO:0031058,GO:0031063,GO:0031065,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031399,GO:0031400,GO:0031401,GO:0031984,GO:0032268,GO:0032269,GO:0032270,GO:0032501,GO:0032991,GO:0033043,GO:0033044,GO:0033555,GO:0033613,GO:0034308,GO:0034754,GO:0035065,GO:0035067,GO:0042175,GO:0042445,GO:0042572,GO:0042574,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043616,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045892,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050673,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0051253,GO:0055114,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090311,GO:0090312,GO:0098827,GO:0140110,GO:1901615,GO:1901983,GO:1901984,GO:1902275,GO:1902679,GO:1903506,GO:1903507,GO:1905268,GO:1905269,GO:2000112,GO:2000113,GO:2000756,GO:2000757,GO:2001141,GO:2001251,GO:2001252	1.1.1.105	ko:K15734	ko00830,map00830	-	R02124	RC00649	ko00000,ko00001,ko01000	-	-	-	adh_short
k59_1059556_2	9541.XP_005566911.1	3.55e-15	75.9	COG3119@1|root,KOG3867@2759|Eukaryota,38DUV@33154|Opisthokonta,3B9HA@33208|Metazoa,3CZ4K@33213|Bilateria,48C1Q@7711|Chordata,48XJH@7742|Vertebrata,3J8EI@40674|Mammalia,35GZ7@314146|Euarchontoglires,4MH5U@9443|Primates,3627U@314294|Cercopithecoidea	33208|Metazoa	P	Arylsulfatase A	ARSA	GO:0000003,GO:0000323,GO:0001669,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0004065,GO:0004098,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005766,GO:0005768,GO:0005773,GO:0005775,GO:0005783,GO:0005788,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006687,GO:0006807,GO:0006810,GO:0006887,GO:0006914,GO:0006950,GO:0006952,GO:0006955,GO:0007275,GO:0007338,GO:0007339,GO:0007399,GO:0007417,GO:0007584,GO:0008037,GO:0008150,GO:0008152,GO:0008484,GO:0009056,GO:0009268,GO:0009566,GO:0009605,GO:0009607,GO:0009617,GO:0009628,GO:0009636,GO:0009897,GO:0009986,GO:0009987,GO:0009988,GO:0009991,GO:0010033,GO:0012505,GO:0016020,GO:0016021,GO:0016192,GO:0016787,GO:0016788,GO:0019897,GO:0019898,GO:0019953,GO:0022414,GO:0030141,GO:0031224,GO:0031232,GO:0031410,GO:0031667,GO:0031974,GO:0031982,GO:0031983,GO:0032501,GO:0032502,GO:0032940,GO:0034774,GO:0035036,GO:0035578,GO:0036230,GO:0042119,GO:0042221,GO:0042493,GO:0042582,GO:0042742,GO:0043167,GO:0043169,GO:0043202,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0043627,GO:0044237,GO:0044238,GO:0044248,GO:0044255,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044703,GO:0045055,GO:0045321,GO:0045471,GO:0046677,GO:0046872,GO:0046903,GO:0048731,GO:0048856,GO:0050896,GO:0051179,GO:0051234,GO:0051597,GO:0051704,GO:0051707,GO:0060205,GO:0061919,GO:0070013,GO:0071704,GO:0071944,GO:0097223,GO:0097305,GO:0097708,GO:0098542,GO:0098552,GO:0099503,GO:1901135,GO:1901564,GO:1901700,GO:1903509	3.1.6.2,3.1.6.8	ko:K01131,ko:K01134,ko:K12381	ko00140,ko00600,ko04142,map00140,map00600,map04142	-	R03404,R04856,R08941,R08942	RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_1823692_1	1123399.AQVE01000032_gene778	5.15e-134	397.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,1RSCT@1236|Gammaproteobacteria,4624S@72273|Thiotrichales	72273|Thiotrichales	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_884551_1	521719.ATXQ01000002_gene2287	4.9e-46	160.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1S2ZF@1236|Gammaproteobacteria,1YEP1@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_884551_2	396588.Tgr7_2009	8.58e-80	246.0	COG2231@1|root,COG2231@2|Bacteria,1RDJ8@1224|Proteobacteria,1RUHP@1236|Gammaproteobacteria,1WXXG@135613|Chromatiales	135613|Chromatiales	L	PFAM HhH-GPD	-	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
k59_1059559_1	1121015.N789_00470	3.24e-92	297.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1X3MZ@135614|Xanthomonadales	135614|Xanthomonadales	F	Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate	carB	GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_943279_1	446471.Xcel_1183	9.32e-78	236.0	COG0233@1|root,COG0233@2|Bacteria,2GJ9J@201174|Actinobacteria,4F3B7@85017|Promicromonosporaceae	201174|Actinobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_356179_1	690850.Desaf_2411	1.09e-28	112.0	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,42S9D@68525|delta/epsilon subdivisions,2WN8Y@28221|Deltaproteobacteria,2MF55@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_648300_1	1185876.BN8_01026	7.82e-51	165.0	COG2954@1|root,COG2954@2|Bacteria,4NNGE@976|Bacteroidetes,47QND@768503|Cytophagia	976|Bacteroidetes	S	CYTH	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CYTH
k59_1059567_1	1121017.AUFG01000002_gene2826	7.81e-18	89.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,4FFJC@85021|Intrasporangiaceae	201174|Actinobacteria	M	Exporter of polyketide	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_356181_1	1123401.JHYQ01000029_gene1956	6.63e-127	367.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,4606Q@72273|Thiotrichales	72273|Thiotrichales	L	Exodeoxyribonuclease III xth	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_1705010_1	1101188.KI912156_gene3796	3.95e-17	80.1	COG0636@1|root,COG0636@2|Bacteria,2IS0Q@201174|Actinobacteria	201174|Actinobacteria	C	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
k59_648303_1	1121405.dsmv_3403	7.83e-77	240.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,2MHV9@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_356186_1	553385.JEMF01000078_gene631	1.22e-07	52.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,1RM7W@1236|Gammaproteobacteria,1XN1Z@135619|Oceanospirillales	135619|Oceanospirillales	E	Required for the activity of the bacterial periplasmic transport system of putrescine	potD	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_8
k59_356186_2	765911.Thivi_0907	3.45e-60	193.0	2CDCV@1|root,308Y1@2|Bacteria,1N74F@1224|Proteobacteria,1S130@1236|Gammaproteobacteria,1WWVV@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_707105_1	335543.Sfum_1829	4.45e-96	307.0	COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MQ8R@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
k59_884576_1	1249627.D779_3023	1.58e-83	260.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales	135613|Chromatiales	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
k59_1059572_2	1151119.KB895490_gene2080	1.27e-80	260.0	COG1940@1|root,COG1940@2|Bacteria,2GNFJ@201174|Actinobacteria,1WAFT@1268|Micrococcaceae	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,ROK
k59_765461_1	1211114.ALIP01000012_gene1405	1.1e-112	334.0	COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,1RRCR@1236|Gammaproteobacteria,1X5H9@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N,HTH_13
k59_1646514_1	1123261.AXDW01000019_gene691	1.63e-114	350.0	COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,1RNJ3@1236|Gammaproteobacteria,1X4IG@135614|Xanthomonadales	135614|Xanthomonadales	M	COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily	-	-	2.7.8.20	ko:K01002	ko01100,map01100	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
k59_589705_1	1417296.U879_08035	6.4e-73	230.0	COG0095@1|root,COG0095@2|Bacteria,1N1T8@1224|Proteobacteria,2U1PC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_1470153_2	314260.PB2503_11979	3.14e-06	48.9	COG0477@1|root,COG2814@2|Bacteria,1N2NP@1224|Proteobacteria,2TXTK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_413373_1	639283.Snov_2324	2.12e-12	65.1	COG1720@1|root,COG1720@2|Bacteria,1MUF0@1224|Proteobacteria,2TVD8@28211|Alphaproteobacteria,3EZVP@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Uncharacterised protein family UPF0066	virR	-	-	-	-	-	-	-	-	-	-	-	UPF0066
k59_707121_1	367299.JOEE01000006_gene811	1.27e-76	241.0	COG2271@1|root,COG2271@2|Bacteria,2I2F7@201174|Actinobacteria,4FFEJ@85021|Intrasporangiaceae	201174|Actinobacteria	G	MFS transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1000377_1	1158762.KB898044_gene293	2.2e-22	98.2	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,1WWMP@135613|Chromatiales	135613|Chromatiales	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_296175_1	388051.AUFE01000090_gene5613	2.16e-35	132.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R2NF@1224|Proteobacteria,2VJDG@28216|Betaproteobacteria,1K59U@119060|Burkholderiaceae	28216|Betaproteobacteria	K	B12 binding domain	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
k59_1176719_1	1190606.AJYG01000077_gene4017	1.29e-104	307.0	COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,1RPKU@1236|Gammaproteobacteria,1XV1E@135623|Vibrionales	135623|Vibrionales	G	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
k59_1000378_1	1116472.MGMO_37c00170	2.89e-106	317.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1XDWR@135618|Methylococcales	135618|Methylococcales	D	recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1587347_1	631362.Thi970DRAFT_04902	1.25e-40	139.0	2BXQF@1|root,32R1T@2|Bacteria,1RJTZ@1224|Proteobacteria,1SUVI@1236|Gammaproteobacteria,1X1W6@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	-
k59_1587347_2	2903.EOD21710	3.56e-07	54.3	COG0488@1|root,KOG0066@2759|Eukaryota	2759|Eukaryota	J	translation activator activity	-	-	-	ko:K06184	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
k59_1823757_1	1049564.TevJSym_av00160	3.46e-96	296.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,1RQ7G@1236|Gammaproteobacteria,1J4EK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	COG0008 Glutamyl- and glutaminyl-tRNA synthetases	glnS	GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECIAI39_1322.ECIAI39_0637	tRNA-synt_1c,tRNA-synt_1c_C
k59_1470170_2	990285.RGCCGE502_07466	1.06e-62	192.0	COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,2U95D@28211|Alphaproteobacteria,4BEN3@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
k59_356233_1	392499.Swit_1701	2.77e-23	101.0	COG0477@1|root,COG2814@2|Bacteria,1QZVG@1224|Proteobacteria,2TYEV@28211|Alphaproteobacteria,2KEM5@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_884625_1	1121861.KB899910_gene743	1.37e-19	87.8	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2TT14@28211|Alphaproteobacteria,2JR2J@204441|Rhodospirillales	204441|Rhodospirillales	G	transport system permease	-	-	-	ko:K02026,ko:K05815,ko:K10238	ko02010,map02010	M00198,M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17,3.A.1.1.3	-	-	BPD_transp_1
k59_884625_2	349521.HCH_00203	5.87e-23	95.5	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,1RZC6@1236|Gammaproteobacteria,1XHI4@135619|Oceanospirillales	135619|Oceanospirillales	P	(ABC) transporter, permease	thuF	-	-	ko:K10237	ko02010,map02010	M00204	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.17	-	-	BPD_transp_1
k59_413394_1	90675.XP_010441513.1	1.47e-77	256.0	COG0466@1|root,KOG2004@2759|Eukaryota,37QRW@33090|Viridiplantae,3GCYG@35493|Streptophyta,3HQ4Z@3699|Brassicales	35493|Streptophyta	O	ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import	-	GO:0000002,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0006139,GO:0006259,GO:0006508,GO:0006605,GO:0006625,GO:0006725,GO:0006807,GO:0006810,GO:0006886,GO:0006950,GO:0006996,GO:0007005,GO:0007031,GO:0007275,GO:0008104,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009791,GO:0009987,GO:0010467,GO:0015031,GO:0015833,GO:0015919,GO:0016043,GO:0016485,GO:0016558,GO:0016560,GO:0017038,GO:0019538,GO:0022622,GO:0031907,GO:0031974,GO:0032042,GO:0032501,GO:0032502,GO:0033036,GO:0033365,GO:0034613,GO:0034641,GO:0040007,GO:0042579,GO:0042886,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043574,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0044743,GO:0045184,GO:0046483,GO:0046907,GO:0048364,GO:0048527,GO:0048528,GO:0048731,GO:0048856,GO:0050896,GO:0051179,GO:0051234,GO:0051604,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071806,GO:0071840,GO:0072594,GO:0072662,GO:0072663,GO:0090304,GO:0090696,GO:0099402,GO:1901360,GO:1901564	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1000388_1	314345.SPV1_09198	2.16e-101	305.0	COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria	1224|Proteobacteria	E	Saccharopine dehydrogenase	LYS1	-	1.5.1.43,1.5.1.7	ko:K00290,ko:K13746	ko00300,ko00310,ko00330,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map00330,map01100,map01110,map01130,map01230	M00030,M00032	R00715,R09079,R09080	RC00053,RC00217,RC00225,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0902	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_413396_1	1121952.ATXT01000013_gene2262	1.78e-19	86.3	2AYVP@1|root,31R17@2|Bacteria,2HT6Y@201174|Actinobacteria,4FS5A@85023|Microbacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_62766_2	754477.Q7C_2503	4.09e-29	116.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,460N2@72273|Thiotrichales	72273|Thiotrichales	S	Permease YjgP YjgQ	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_3446_1	1300345.LF41_2645	1.24e-37	144.0	COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,1X3S5@135614|Xanthomonadales	135614|Xanthomonadales	J	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA	rlmL	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.173,2.1.1.264	ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
k59_472232_1	572477.Alvin_0109	4.08e-115	339.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria,1WWVX@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_356245_2	314278.NB231_10828	4.9e-38	132.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,1S25H@1236|Gammaproteobacteria,1WY0Q@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
k59_765499_1	1419583.V466_30940	2.3e-48	176.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GAF_2,GGDEF,PAS,PAS_9
k59_62776_1	446466.Cfla_2285	7.32e-103	312.0	COG1271@1|root,COG1271@2|Bacteria,2GJE4@201174|Actinobacteria,4F0IB@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM cytochrome bd ubiquinol oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_472237_1	88036.EFJ32507	6.08e-15	77.4	COG0820@1|root,2QSIE@2759|Eukaryota,37IKH@33090|Viridiplantae,3G9VD@35493|Streptophyta	35493|Streptophyta	J	Ribosomal RNA large subunit methyltransferase	-	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
k59_472237_2	1307759.JOMJ01000003_gene2182	8.2e-09	60.5	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2WIQD@28221|Deltaproteobacteria,2MGCQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_707163_1	761193.Runsl_5361	5.82e-100	305.0	COG1866@1|root,COG1866@2|Bacteria,4NEGI@976|Bacteroidetes,47JC3@768503|Cytophagia	976|Bacteroidetes	H	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
k59_3484_1	261292.Nit79A3_1885	2.89e-44	155.0	COG0240@1|root,COG0240@2|Bacteria,1RED0@1224|Proteobacteria,2W2AD@28216|Betaproteobacteria	28216|Betaproteobacteria	I	PFAM NAD-dependent glycerol-3-phosphate dehydrogenase	-	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_1825053_1	1283299.AUKG01000005_gene58	1.09e-11	61.2	COG0261@1|root,COG0261@2|Bacteria,2IQ9A@201174|Actinobacteria,4CQJ4@84995|Rubrobacteria	84995|Rubrobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
k59_1825053_2	525909.Afer_0772	1.6e-29	107.0	COG0211@1|root,COG0211@2|Bacteria,2IQDI@201174|Actinobacteria,4CN91@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal L27 protein	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
k59_1296968_1	1255043.TVNIR_1180	5.85e-67	215.0	COG0446@1|root,COG0446@2|Bacteria,1QA17@1224|Proteobacteria,1RSA6@1236|Gammaproteobacteria,1WXMR@135613|Chromatiales	135613|Chromatiales	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1529607_1	1049564.TevJSym_bb00340	6.93e-44	157.0	COG2199@1|root,COG3706@2|Bacteria,1NE0J@1224|Proteobacteria,1SF4P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase, GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_1529607_2	1294143.H681_23945	1.13e-07	53.9	COG3072@1|root,COG3072@2|Bacteria,1PI5T@1224|Proteobacteria,1RMPZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Adenylate cyclase	cyaA	GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0052652,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.1	ko:K05851	ko00230,ko02026,ko05111,map00230,map02026,map05111	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_2672,iECOK1_1307.ECOK1_4253,iECS88_1305.ECS88_4229,iUMN146_1321.UM146_19155,iUTI89_1310.UTI89_C4365	Adenyl_cycl_N,Adenylate_cycl
k59_4714_1	472759.Nhal_3387	2e-51	174.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RPMN@1236|Gammaproteobacteria,1WVVR@135613|Chromatiales	135613|Chromatiales	M	PFAM glycosyl transferase family 9	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
k59_649265_1	864051.BurJ1DRAFT_2122	5.5e-91	282.0	COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,2VHTR@28216|Betaproteobacteria,1KJNW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	deoxyribodipyrimidine photolyase-related protein	-	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP
k59_1647434_1	1123392.AQWL01000008_gene1238	2.7e-35	133.0	COG3292@1|root,COG3292@2|Bacteria,1QMJ4@1224|Proteobacteria,2VNHI@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
k59_825060_1	648757.Rvan_0785	7.72e-27	106.0	2EE7W@1|root,3382F@2|Bacteria,1NFC5@1224|Proteobacteria,2UINU@28211|Alphaproteobacteria,3N8WG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	EF hand	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5
k59_825060_2	639283.Snov_2370	2.94e-05	45.1	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2TR47@28211|Alphaproteobacteria,3EY78@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Glucose / Sorbosone dehydrogenase	yliI	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0055114,GO:0070968,GO:0097159,GO:1901363	1.1.5.2	ko:K00117,ko:K21430	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	GSDH
k59_590681_1	688245.CtCNB1_2028	3.29e-86	273.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2VHYV@28216|Betaproteobacteria,4A9K7@80864|Comamonadaceae	28216|Betaproteobacteria	H	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysN	-	2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_1529610_1	1123401.JHYQ01000007_gene542	2.74e-174	514.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,461JN@72273|Thiotrichales	72273|Thiotrichales	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_64088_2	1304883.KI912532_gene2329	1.69e-60	193.0	COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,2VRE4@28216|Betaproteobacteria,2KWM9@206389|Rhodocyclales	206389|Rhodocyclales	S	AMMECR1	-	-	-	-	-	-	-	-	-	-	-	-	AMMECR1
k59_1825062_1	1349820.M707_11855	4.36e-57	194.0	COG4942@1|root,COG4942@2|Bacteria,2GW48@201174|Actinobacteria	201174|Actinobacteria	D	Protein of unknown function (DUF3375)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3375
k59_64091_1	471853.Bcav_1901	2.17e-88	280.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria	201174|Actinobacteria	I	AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_708039_1	1278971.AOGF01000003_gene1437	6.87e-11	58.2	COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,1Y9D6@135625|Pasteurellales	135625|Pasteurellales	J	Belongs to the universal ribosomal protein uL29 family	rpmC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
k59_708039_2	1283300.ATXB01000001_gene619	3.52e-73	221.0	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,1S201@1236|Gammaproteobacteria,1XF05@135618|Methylococcales	135618|Methylococcales	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
k59_120996_1	314345.SPV1_06994	2.6e-68	219.0	COG2367@1|root,COG2367@2|Bacteria,1R6KF@1224|Proteobacteria	1224|Proteobacteria	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
k59_1296992_1	29581.BW37_01016	7.91e-51	173.0	COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,2VQ7D@28216|Betaproteobacteria,478QU@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_1001144_2	713586.KB900536_gene2893	3.17e-63	216.0	COG0720@1|root,COG0720@2|Bacteria,1PNDM@1224|Proteobacteria,1S7ZW@1236|Gammaproteobacteria,1WZ30@135613|Chromatiales	135613|Chromatiales	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
k59_1588203_1	525245.HMPREF0044_1233	4.42e-54	179.0	COG0016@1|root,COG0016@2|Bacteria,2GJGG@201174|Actinobacteria,4D3CY@85005|Actinomycetales	201174|Actinobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_1588203_2	1123065.ATWL01000011_gene87	2.32e-30	119.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2GMFD@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_238731_1	1151122.AQYD01000005_gene3596	6.77e-100	296.0	COG0559@1|root,COG0559@2|Bacteria,2GKAR@201174|Actinobacteria,4FPHI@85023|Microbacteriaceae	201174|Actinobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1412453_1	765912.Thimo_1168	1.75e-25	100.0	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,1WY1N@135613|Chromatiales	135613|Chromatiales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
k59_1412453_2	768671.ThimaDRAFT_2603	3.07e-36	134.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1WVYR@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_649290_1	246196.MSMEI_3622	1.44e-12	72.8	COG1835@1|root,COG1835@2|Bacteria,2GN56@201174|Actinobacteria,234N5@1762|Mycobacteriaceae	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_944780_1	335543.Sfum_1542	2.08e-07	47.8	COG0267@1|root,COG0267@2|Bacteria,1NJ67@1224|Proteobacteria,42V5X@68525|delta/epsilon subdivisions,2WSIR@28221|Deltaproteobacteria,2MSDW@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
k59_1825092_1	460265.Mnod_7136	3.22e-32	123.0	COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2TUGE@28211|Alphaproteobacteria,1JWWY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_121009_1	765912.Thimo_1853	1e-151	432.0	COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RXZ5@1236|Gammaproteobacteria,1WXP8@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator, LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_357634_1	251221.35211948	7.11e-69	231.0	COG0457@1|root,COG0457@2|Bacteria,1G1UY@1117|Cyanobacteria	1117|Cyanobacteria	S	Alternative locus ID	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_1,TPR_11,TPR_16,TPR_2,TPR_7,TPR_8
k59_1177605_1	880072.Desac_0608	9.73e-74	242.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2WIPR@28221|Deltaproteobacteria,2MQB8@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Ftsk_gamma	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1060572_1	1123065.ATWL01000045_gene1073	2.46e-80	247.0	28JJ5@1|root,2Z9C9@2|Bacteria,2HB8W@201174|Actinobacteria	201174|Actinobacteria	S	infection protein	-	-	-	-	-	-	-	-	-	-	-	-	Abi
k59_4750_1	317025.Tcr_0783	3.93e-146	424.0	COG0225@1|root,COG0229@1|root,COG0526@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,COG0526@2|Bacteria,1MVUS@1224|Proteobacteria,1T0T1@1236|Gammaproteobacteria,460U4@72273|Thiotrichales	72273|Thiotrichales	CO	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR,Thioredoxin_2
k59_1412457_1	1267005.KB911257_gene718	1.1e-111	347.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2TU7G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
k59_1412457_2	1267005.KB911257_gene719	1.65e-24	103.0	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	-	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	Laminin_G_3,PKD,TIG,TPP_enzyme_M,fn3
k59_1705991_1	446466.Cfla_2892	1.68e-85	262.0	COG1562@1|root,COG1562@2|Bacteria,2GJN2@201174|Actinobacteria,4F0N7@85016|Cellulomonadaceae	201174|Actinobacteria	I	Squalene/phytoene synthase	crtB	GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
k59_1412459_1	1198452.Jab_2c03350	9.25e-140	407.0	COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,2W0HG@28216|Betaproteobacteria,4727U@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4478)	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DUF3412,DUF4478,Lysine_decarbox
k59_531937_1	1049564.TevJSym_ba00120	2.81e-41	150.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1J565@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	zinc metalloprotease	rseP	GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_414256_1	95619.PM1_0217265	3.16e-45	167.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019538,GO:0019752,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0070569,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_414256_2	1304275.C41B8_12065	1.23e-98	292.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Methionine aminopeptidase	map	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_944809_1	1177928.TH2_00895	1.68e-14	77.8	COG0697@1|root,COG0697@2|Bacteria,1MX07@1224|Proteobacteria,2TQNT@28211|Alphaproteobacteria,2JRSM@204441|Rhodospirillales	204441|Rhodospirillales	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_649314_1	367299.JOEE01000001_gene1796	1.14e-136	404.0	COG0365@1|root,COG0365@2|Bacteria,2GP7N@201174|Actinobacteria,4FEXP@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acetyl-coenzyme A synthetase N-terminus	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1236410_1	768671.ThimaDRAFT_3002	2.16e-95	311.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RMPV@1236|Gammaproteobacteria,1WW6H@135613|Chromatiales	135613|Chromatiales	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_1177621_2	573370.DMR_05610	1.05e-46	169.0	COG1219@1|root,COG1219@2|Bacteria,1NS53@1224|Proteobacteria,42YDC@68525|delta/epsilon subdivisions,2WU6T@28221|Deltaproteobacteria,2MAA0@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	AAA domain (Cdc48 subfamily)	-	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2
k59_473178_1	338963.Pcar_2329	4.13e-18	88.2	COG1719@1|root,COG3437@1|root,COG1719@2|Bacteria,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42T7G@68525|delta/epsilon subdivisions,2WKC5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GGDEF,HD,HD_5,dCache_2
k59_1647494_1	1429046.RR21198_5916	3.03e-97	304.0	COG4974@1|root,COG4974@2|Bacteria,2IBD6@201174|Actinobacteria,4G27D@85025|Nocardiaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_int_SAM_5,Phage_integrase
k59_1529665_1	349521.HCH_06735	4.13e-66	223.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XHBW@135619|Oceanospirillales	135619|Oceanospirillales	P	P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_766284_1	768671.ThimaDRAFT_1362	1.3e-100	309.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales	135613|Chromatiales	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_1529668_1	1485544.JQKP01000003_gene122	2.57e-54	171.0	COG2920@1|root,COG2920@2|Bacteria,1RITK@1224|Proteobacteria,2W32H@28216|Betaproteobacteria,44WIY@713636|Nitrosomonadales	28216|Betaproteobacteria	P	DsrC like protein	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_1353740_2	187272.Mlg_0464	6.92e-55	177.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,1WVYC@135613|Chromatiales	135613|Chromatiales	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_1412490_1	1203190.CAJP01000038_gene1362	1.99e-14	78.6	COG4425@1|root,COG4425@2|Bacteria,2GKB5@201174|Actinobacteria,22K6I@1653|Corynebacteriaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_9,Abhydrolase_9_N
k59_886044_1	1229780.BN381_80248	1.12e-41	154.0	COG5421@1|root,COG5421@2|Bacteria,2GK2A@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_121061_1	7955.ENSDARP00000106282	3.7e-55	196.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,48DPU@7711|Chordata,49A9G@7742|Vertebrata	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_238800_1	313589.JNB_00335	6.16e-33	135.0	COG2909@1|root,COG2909@2|Bacteria,2HEX2@201174|Actinobacteria,4FF31@85021|Intrasporangiaceae	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
k59_649347_1	289376.THEYE_A1361	2.86e-45	153.0	COG1392@1|root,COG1392@2|Bacteria	2|Bacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_649347_2	1499967.BAYZ01000047_gene2737	9.09e-07	49.7	COG0306@1|root,COG0306@2|Bacteria,2NPA2@2323|unclassified Bacteria	2|Bacteria	U	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_297243_2	523791.Kkor_0442	1.16e-47	155.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,1S5XT@1236|Gammaproteobacteria,1XK4T@135619|Oceanospirillales	135619|Oceanospirillales	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_297243_3	754477.Q7C_2403	4.89e-120	347.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,45ZXA@72273|Thiotrichales	72273|Thiotrichales	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_297243_4	477228.YO5_05614	1.82e-75	227.0	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,1S201@1236|Gammaproteobacteria,1Z2QR@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
k59_297243_5	713586.KB900536_gene1162	4.21e-19	79.7	COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,1WZ6K@135613|Chromatiales	135613|Chromatiales	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
k59_64226_1	765912.Thimo_0895	2.56e-75	251.0	COG4678@1|root,COG4678@2|Bacteria,1MXCR@1224|Proteobacteria,1RPZR@1236|Gammaproteobacteria,1WW1Z@135613|Chromatiales	135613|Chromatiales	G	PFAM TraG-like protein, N-terminal region	-	-	-	ko:K12056	-	-	-	-	ko00000,ko02044	3.A.7.11.1	-	-	TraG_N
k59_297246_2	396588.Tgr7_0047	4.08e-62	202.0	COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1WW4W@135613|Chromatiales	135613|Chromatiales	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1647530_2	1089455.MOPEL_094_00020	3.76e-47	165.0	COG4284@1|root,COG4284@2|Bacteria,2I2G3@201174|Actinobacteria,4F6B8@85018|Dermatophilaceae	201174|Actinobacteria	G	UTP--glucose-1-phosphate uridylyltransferase	ugp	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPGP
k59_1118593_1	1049564.TevJSym_ah00320	8.51e-32	124.0	COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,1RNF3@1236|Gammaproteobacteria,1J65J@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	MucB/RseB C-terminal domain	rseB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0044464,GO:0045152	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	MucB_RseB,MucB_RseB_C
k59_532000_1	314271.RB2654_06714	1.41e-09	61.2	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2UC0F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_825163_1	1430440.MGMSRv2_0212	9.93e-15	74.7	28PEX@1|root,2ZC6C@2|Bacteria,1RADH@1224|Proteobacteria,2UF1E@28211|Alphaproteobacteria,2JUIT@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp
k59_65400_1	1167006.UWK_03322	3.66e-106	313.0	COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,42QAT@68525|delta/epsilon subdivisions,2WJMX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,IstB_IS21_ATP
k59_1001816_1	998674.ATTE01000001_gene1730	1.58e-78	250.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,1RPYD@1236|Gammaproteobacteria,45ZVB@72273|Thiotrichales	72273|Thiotrichales	S	Bacterial protein of unknown function (DUF853)	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
k59_1001816_2	879212.DespoDRAFT_03452	3.59e-39	142.0	COG0500@1|root,COG1047@1|root,COG1047@2|Bacteria,COG2226@2|Bacteria,1PCH2@1224|Proteobacteria,42M58@68525|delta/epsilon subdivisions,2WK5Z@28221|Deltaproteobacteria,2MIYH@213118|Desulfobacterales	28221|Deltaproteobacteria	OQ	PFAM Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_1354532_1	1121456.ATVA01000013_gene996	8.9e-81	258.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,42MUF@68525|delta/epsilon subdivisions,2WK25@28221|Deltaproteobacteria,2MGDJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	DNA methylase	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
k59_1354532_2	207559.Dde_1862	6.11e-39	129.0	COG3311@1|root,COG3311@2|Bacteria,1N779@1224|Proteobacteria,42VDM@68525|delta/epsilon subdivisions,2WR6J@28221|Deltaproteobacteria,2MDKV@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	TIGRFAM DNA binding domain protein, excisionase family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
k59_1298260_1	177439.DP1202	1.45e-86	272.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,2MHX9@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_1826396_2	643867.Ftrac_0076	8.03e-74	227.0	COG0494@1|root,COG0494@2|Bacteria,4NMHV@976|Bacteroidetes,47P7M@768503|Cytophagia	976|Bacteroidetes	L	pfam nudix	nudF	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_180471_1	886293.Sinac_7397	1.04e-137	406.0	COG1861@1|root,COG1861@2|Bacteria,2J3F7@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_5841_2	1121405.dsmv_1235	2.96e-77	238.0	COG0412@1|root,COG0412@2|Bacteria,1NKIB@1224|Proteobacteria,43B7J@68525|delta/epsilon subdivisions,2X6KZ@28221|Deltaproteobacteria,2MMAU@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
k59_1530457_1	525244.HMPREF0023_0195	9.76e-13	68.6	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,3NJVQ@468|Moraxellaceae	1236|Gammaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_1530457_2	519989.ECTPHS_03172	1.84e-17	81.6	COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,1WXGQ@135613|Chromatiales	135613|Chromatiales	S	High frequency lysogenization protein HflD homolog	hflD	-	-	ko:K07153	-	-	-	-	ko00000	-	-	-	DUF489
k59_766936_2	396595.TK90_0560	9.99e-23	90.9	COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,1SCPF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the acylphosphatase family	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	iSBO_1134.SBO_2263,iSF_1195.SF0969,iSFxv_1172.SFxv_1053,iS_1188.S1036	Acylphosphatase
k59_766936_3	1415780.JPOG01000001_gene1037	9.75e-52	168.0	COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,1S3XT@1236|Gammaproteobacteria,1X6G6@135614|Xanthomonadales	135614|Xanthomonadales	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_65422_1	945543.VIBR0546_07652	5.61e-38	135.0	COG1595@1|root,COG1595@2|Bacteria,1R9ZN@1224|Proteobacteria,1S27W@1236|Gammaproteobacteria,1Y2D5@135623|Vibrionales	135623|Vibrionales	K	Belongs to the sigma-70 factor family. ECF subfamily	sigV	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1648311_1	998674.ATTE01000001_gene2119	1.25e-15	75.1	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,460Q4@72273|Thiotrichales	72273|Thiotrichales	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_1648311_2	1123368.AUIS01000008_gene2202	1.53e-101	313.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,2NBVU@225057|Acidithiobacillales	225057|Acidithiobacillales	J	Ribonuclease E/G family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_591542_1	367299.JOEE01000004_gene1294	1.81e-90	273.0	COG0583@1|root,COG0583@2|Bacteria,2GKT0@201174|Actinobacteria,4FFNX@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_887225_1	1049564.TevJSym_aj00140	4.13e-40	147.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1J4R0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	COG0642 Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,Response_reg
k59_1589022_2	883126.HMPREF9710_04485	2.96e-81	256.0	COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,2W0HG@28216|Betaproteobacteria,4727U@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4478)	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DUF3412,DUF4478,Lysine_decarbox
k59_708833_1	96561.Dole_2673	3.55e-20	96.3	COG0272@1|root,COG0507@1|root,COG0272@2|Bacteria,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2WJD6@28221|Deltaproteobacteria,2MINC@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	-	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
k59_825926_1	225937.HP15_2436	1.51e-14	72.4	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,465CS@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	mlaF	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0008144,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_825926_2	570967.JMLV01000003_gene2306	4.69e-29	111.0	COG1959@1|root,COG1959@2|Bacteria,1N0E2@1224|Proteobacteria,2U9Z9@28211|Alphaproteobacteria,2JT9W@204441|Rhodospirillales	204441|Rhodospirillales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
k59_1237312_1	768671.ThimaDRAFT_1939	5.01e-152	441.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,1T5B6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_766943_1	1386089.N865_04705	2.98e-65	211.0	COG0433@1|root,COG0433@2|Bacteria,2HUQ6@201174|Actinobacteria,4FF14@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function DUF87	-	-	-	-	-	-	-	-	-	-	-	-	DUF87
k59_591551_2	626887.J057_03535	2.42e-51	176.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,463YI@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008883,GO:0009058,GO:0009064,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_1375,iECSF_1327.ECSF_1186,iUTI89_1310.UTI89_C1404	GlutR_N,GlutR_dimer,Shikimate_DH
k59_946077_1	519989.ECTPHS_07027	1.2e-34	127.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,1WW6U@135613|Chromatiales	135613|Chromatiales	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
k59_946077_2	292415.Tbd_1135	1.62e-35	134.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2VI3U@28216|Betaproteobacteria,1KRIN@119069|Hydrogenophilales	119069|Hydrogenophilales	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1765201_2	519989.ECTPHS_11707	2.66e-17	77.4	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,1S40Q@1236|Gammaproteobacteria,1WZ4B@135613|Chromatiales	135613|Chromatiales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_1472066_1	583355.Caka_2609	2.29e-18	90.1	COG1283@1|root,COG1283@2|Bacteria,46XC7@74201|Verrucomicrobia,3K8B5@414999|Opitutae	414999|Opitutae	P	Na+/Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
k59_65438_1	401053.AciPR4_0061	1.34e-38	142.0	COG0607@1|root,COG5553@1|root,COG0607@2|Bacteria,COG5553@2|Bacteria,3Y6PN@57723|Acidobacteria,2JMI6@204432|Acidobacteriia	204432|Acidobacteriia	C	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	CDO_I,Rhodanese
k59_65438_2	1120949.KB903299_gene6034	3.8e-58	189.0	COG3386@1|root,COG3386@2|Bacteria,2GIW1@201174|Actinobacteria,4D8E7@85008|Micromonosporales	201174|Actinobacteria	G	SMP-30/Gluconolaconase/LRE-like region	gnl	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_1472071_1	398767.Glov_1333	1.44e-13	67.4	COG0690@1|root,COG0690@2|Bacteria,1Q1BI@1224|Proteobacteria,42X4Z@68525|delta/epsilon subdivisions,2WSQ8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
k59_1119240_1	880072.Desac_0711	5.54e-36	125.0	COG0720@1|root,COG0720@2|Bacteria,1RI4P@1224|Proteobacteria,42TJ5@68525|delta/epsilon subdivisions,2WQ2Z@28221|Deltaproteobacteria,2MRZN@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	PFAM 6-pyruvoyl tetrahydropterin synthase	queD	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
k59_121831_1	935839.JAGJ01000012_gene2937	4.66e-96	288.0	COG0559@1|root,COG0559@2|Bacteria,2GMAY@201174|Actinobacteria,4F40G@85017|Promicromonosporaceae	201174|Actinobacteria	P	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_65459_1	1268622.AVS7_03636	5.76e-44	156.0	COG1711@1|root,COG1711@2|Bacteria,1RIA0@1224|Proteobacteria,2VIHJ@28216|Betaproteobacteria,4AB02@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3014)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3014
k59_708858_1	2340.JV46_13300	2.88e-96	310.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J582@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18989	-	M00720	-	-	ko00000,ko00002,ko02000	2.A.6.2.30	-	-	ACR_tran
k59_1354585_1	1163407.UU7_03552	4.31e-87	272.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1X3UC@135614|Xanthomonadales	135614|Xanthomonadales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_474016_1	1283299.AUKG01000001_gene2609	2.17e-78	261.0	COG0085@1|root,COG0085@2|Bacteria,2GJ81@201174|Actinobacteria,4CPMH@84995|Rubrobacteria	84995|Rubrobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_415117_1	2340.JV46_04430	1.43e-82	251.0	COG1277@1|root,COG1277@2|Bacteria,1MWUZ@1224|Proteobacteria,1RQFG@1236|Gammaproteobacteria,1JBG1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	ABC-2 family transporter protein	nosY	-	-	ko:K19341	ko02010,map02010	M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.132.2	-	-	ABC2_membrane_2
k59_1237354_1	1304865.JAGF01000001_gene2992	2.27e-101	320.0	COG1033@1|root,COG2409@1|root,COG1033@2|Bacteria,COG2409@2|Bacteria,2GIRQ@201174|Actinobacteria,4F0TE@85016|Cellulomonadaceae	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
k59_708870_1	686340.Metal_1790	4.45e-29	115.0	COG1344@1|root,COG1344@2|Bacteria,1PJUJ@1224|Proteobacteria,1RPNR@1236|Gammaproteobacteria,1XDY8@135618|Methylococcales	135618|Methylococcales	N	Belongs to the bacterial flagellin family	-	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
k59_180524_1	118161.KB235922_gene2849	1.62e-63	213.0	COG3204@1|root,COG3204@2|Bacteria	2|Bacteria	L	pilus organization	-	-	-	ko:K02674,ko:K07004	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Big_4,Cadherin,Exo_endo_phos,HemolysinCabind,LTD,Laminin_G_3,PA14,SNase,SdiA-regulated
k59_65477_1	316056.RPC_3132	1.9e-07	60.8	COG3829@1|root,COG3852@1|root,COG3829@2|Bacteria,COG3852@2|Bacteria,1QW3X@1224|Proteobacteria,2TY09@28211|Alphaproteobacteria,3K6VB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,Response_reg
k59_1178496_1	1131553.JIBI01000014_gene871	1.07e-48	168.0	COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,2VNGX@28216|Betaproteobacteria,3728S@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
k59_1354593_1	1379698.RBG1_1C00001G0172	2.79e-35	130.0	COG1825@1|root,COG1825@2|Bacteria,2NPVU@2323|unclassified Bacteria	2|Bacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_1354593_2	1121405.dsmv_3387	7.28e-42	143.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,42RGU@68525|delta/epsilon subdivisions,2WPHH@28221|Deltaproteobacteria,2MJYY@213118|Desulfobacterales	28221|Deltaproteobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
k59_825974_1	314345.SPV1_13202	1.77e-100	305.0	COG0531@1|root,COG0531@2|Bacteria,1QXK2@1224|Proteobacteria	1224|Proteobacteria	E	amino acid	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	AA_permease_2
k59_1298356_2	1463858.JOHR01000010_gene3782	4.22e-21	94.0	COG0282@1|root,COG0282@2|Bacteria,2GJAW@201174|Actinobacteria	201174|Actinobacteria	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0409	Acetate_kinase
k59_239905_1	1120941.AUBL01000010_gene414	7.34e-60	190.0	COG0118@1|root,COG0118@2|Bacteria,2GIYS@201174|Actinobacteria,4D4P5@85005|Actinomycetales	201174|Actinobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_239905_2	266940.Krad_3173	1.25e-87	264.0	COG0106@1|root,COG0106@2|Bacteria,2GJ4V@201174|Actinobacteria	201174|Actinobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16,5.3.1.24	ko:K01814,ko:K01817	ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230	M00023,M00026	R03509,R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_1119273_1	717785.HYPMC_4633	1.58e-08	55.1	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria,3N6AE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_1237370_2	93220.LV28_09820	4.57e-42	148.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,1K263@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_1298358_1	765913.ThidrDRAFT_2655	2.74e-73	226.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1WX9P@135613|Chromatiales	135613|Chromatiales	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_1298358_2	765913.ThidrDRAFT_2654	1.51e-76	236.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1WW3F@135613|Chromatiales	135613|Chromatiales	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
k59_650209_1	1122614.JHZF01000020_gene154	2.77e-129	375.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2TU72@28211|Alphaproteobacteria,2PDXA@252301|Oceanicola	28211|Alphaproteobacteria	L	HTH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_1648374_1	1232437.KL662001_gene4574	4.52e-91	276.0	COG1899@1|root,COG1899@2|Bacteria,1R3WQ@1224|Proteobacteria,42M57@68525|delta/epsilon subdivisions,2WJ6N@28221|Deltaproteobacteria,2MHW7@213118|Desulfobacterales	28221|Deltaproteobacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_5963_1	1121033.AUCF01000008_gene5666	1.39e-42	155.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2TS8U@28211|Alphaproteobacteria,2JPQ0@204441|Rhodospirillales	204441|Rhodospirillales	I	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
k59_1826497_1	717785.HYPMC_3073	5.46e-174	492.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2TSVJ@28211|Alphaproteobacteria,3N61S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Sodium Bile acid symporter family	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
k59_1237380_1	497964.CfE428DRAFT_3619	8.53e-24	107.0	COG0515@1|root,COG4886@1|root,COG0515@2|Bacteria,COG4886@2|Bacteria,46VB0@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FHA,Pkinase
k59_1472152_1	593907.Celgi_0750	8.32e-110	326.0	COG0142@1|root,COG0142@2|Bacteria,2GMB4@201174|Actinobacteria,4F0TF@85016|Cellulomonadaceae	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	hepT	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_1706870_1	1514668.JOOA01000001_gene154	8.16e-93	293.0	COG3968@1|root,COG3968@2|Bacteria,1UHUF@1239|Firmicutes,2481B@186801|Clostridia,3WHCK@541000|Ruminococcaceae	186801|Clostridia	S	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
k59_239931_2	1249627.D779_3791	7.05e-26	98.6	2EH48@1|root,33AW7@2|Bacteria,1NIYU@1224|Proteobacteria,1SEZV@1236|Gammaproteobacteria,1WZ9F@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_65520_1	883126.HMPREF9710_00123	1.54e-84	267.0	COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2VHA2@28216|Betaproteobacteria	28216|Betaproteobacteria	V	PFAM secretion protein HlyD family protein	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_825997_1	1157708.KB907451_gene4588	4.52e-11	69.7	COG2114@1|root,COG2114@2|Bacteria,1RBTC@1224|Proteobacteria,2VS62@28216|Betaproteobacteria,4AE5Z@80864|Comamonadaceae	28216|Betaproteobacteria	T	SMART adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,dCache_1
k59_239936_1	196162.Noca_4344	9.05e-68	220.0	COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria,4DNMU@85009|Propionibacteriales	201174|Actinobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_767005_1	1194972.MVAC_06267	3.62e-40	144.0	2E74C@1|root,331NT@2|Bacteria,2H2EE@201174|Actinobacteria,23CIW@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1472163_1	350058.Mvan_3177	1.23e-44	161.0	COG3677@1|root,COG3677@2|Bacteria,2IF2C@201174|Actinobacteria,23CXG@1762|Mycobacteriaceae	201174|Actinobacteria	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_1648395_2	1071679.BG57_12795	3.75e-80	254.0	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VI39@28216|Betaproteobacteria,1KHV1@119060|Burkholderiaceae	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_66277_2	748280.NH8B_0361	8.62e-31	112.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2VU1C@28216|Betaproteobacteria,2KRGC@206351|Neisseriales	206351|Neisseriales	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_592152_1	1158760.AQXP01000024_gene2273	4.23e-21	86.7	2DX2X@1|root,32V2M@2|Bacteria,1MZZC@1224|Proteobacteria,1S4WN@1236|Gammaproteobacteria,1WYAX@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_592152_2	2340.JV46_28190	7.06e-52	168.0	2AAM4@1|root,30ZYM@2|Bacteria,1RFTG@1224|Proteobacteria,1S4UQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2384
k59_1238047_1	1304865.JAGF01000001_gene1830	5.7e-202	579.0	COG1333@1|root,COG1333@2|Bacteria,2GMGH@201174|Actinobacteria,4F0PR@85016|Cellulomonadaceae	201174|Actinobacteria	O	ResB-like family	-	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
k59_1238047_2	471853.Bcav_3251	5.78e-51	173.0	COG0755@1|root,COG0755@2|Bacteria,2GJR1@201174|Actinobacteria	201174|Actinobacteria	O	cytochrome C	ccsB	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
k59_1238048_2	1265505.ATUG01000001_gene4625	9.19e-16	76.6	COG1024@1|root,COG1024@2|Bacteria,1QY95@1224|Proteobacteria,42N5K@68525|delta/epsilon subdivisions,2WK1G@28221|Deltaproteobacteria,2MHYP@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	bamA	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788	3.7.1.21	ko:K07539	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05593,R05594,R10696	RC01430,RC01431,RC03237	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_709459_1	1049564.TevJSym_ai00340	4.43e-84	272.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1J534@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0031249,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0050896,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_946968_1	29486.NJ56_12700	1.42e-18	79.0	COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,1S3Z3@1236|Gammaproteobacteria,41FXG@629|Yersinia	1236|Gammaproteobacteria	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
k59_946968_2	95619.PM1_0200680	3.03e-37	127.0	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
k59_946968_3	1249627.D779_3564	4.67e-25	94.7	COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,1WZ6K@135613|Chromatiales	135613|Chromatiales	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
k59_415736_2	765913.ThidrDRAFT_3644	5.8e-170	489.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,1WW8I@135613|Chromatiales	135613|Chromatiales	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_1707398_1	2340.JV46_17250	8.73e-132	394.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,1J4WH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	COG0514 Superfamily II DNA helicase	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
k59_888105_1	105425.BBPL01000021_gene856	3.18e-68	223.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,2NHGH@228398|Streptacidiphilus	201174|Actinobacteria	F	Glutamine amidotransferase domain	purF	GO:0008150,GO:0040007	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
k59_1179046_1	1304885.AUEY01000030_gene2429	3.56e-142	416.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,42M90@68525|delta/epsilon subdivisions,2WJ9G@28221|Deltaproteobacteria,2MHV2@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_1531118_2	1304865.JAGF01000001_gene1664	2.51e-39	139.0	COG1477@1|root,COG1477@2|Bacteria,2GN6F@201174|Actinobacteria	201174|Actinobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_122417_1	387093.SUN_0516	1.26e-09	64.3	2C6CZ@1|root,32R7W@2|Bacteria,1RH5F@1224|Proteobacteria,42NQC@68525|delta/epsilon subdivisions,2YS4Q@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Protein of unknown function (DUF2868)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2868
k59_1827329_1	224915.bbp_141	1.36e-16	84.3	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,37D2S@32199|Buchnera	1236|Gammaproteobacteria	A	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_7041_1	519989.ECTPHS_03919	8.42e-134	387.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,1WWU0@135613|Chromatiales	135613|Chromatiales	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_7041_3	2340.JV46_15770	2.16e-39	136.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria,1J6MD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yqgF	GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
k59_7041_4	105559.Nwat_2735	2.67e-13	67.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1WX8T@135613|Chromatiales	135613|Chromatiales	K	Belongs to the UPF0301 (AlgH) family	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_1238066_1	494419.ALPM01000007_gene1842	1.99e-60	199.0	COG2801@1|root,COG3415@1|root,COG2801@2|Bacteria,COG3415@2|Bacteria,2ITEV@201174|Actinobacteria,1WBN4@1268|Micrococcaceae	201174|Actinobacteria	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,HTH_32,rve,rve_3
k59_1062202_1	471853.Bcav_3216	5.31e-131	390.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_888115_1	561175.KB894096_gene763	6.23e-11	59.3	2E3SR@1|root,32YQ8@2|Bacteria,2GQKG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_888115_2	1304865.JAGF01000001_gene3627	1.78e-57	194.0	COG3346@1|root,COG3346@2|Bacteria,2GR90@201174|Actinobacteria,4F17F@85016|Cellulomonadaceae	201174|Actinobacteria	S	SURF1 family	-	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	SURF1
k59_888115_3	1449355.JQNR01000002_gene6268	2.34e-11	60.5	2E4I7@1|root,32ZDA@2|Bacteria,2IQBB@201174|Actinobacteria	201174|Actinobacteria	S	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_888115_4	1123065.ATWL01000001_gene544	1.55e-164	474.0	COG0488@1|root,COG0488@2|Bacteria,2GKQ4@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	ybiT	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn,DLIC
k59_1827342_1	296591.Bpro_4279	3.85e-66	224.0	COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2VNDM@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Spermine/spermidine synthase domain	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
k59_1472978_1	237368.SCABRO_02564	1.14e-33	131.0	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,2IZEZ@203682|Planctomycetes	203682|Planctomycetes	S	Memo-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AMMECR1,Memo
k59_7051_1	1205680.CAKO01000002_gene2231	1.86e-05	46.2	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,2JPED@204441|Rhodospirillales	204441|Rhodospirillales	I	acetyl-coa acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C
k59_359791_1	1279009.ADICEAN_03078	6.54e-72	233.0	COG0457@1|root,COG0457@2|Bacteria,4NFIY@976|Bacteroidetes,47P0R@768503|Cytophagia	976|Bacteroidetes	S	Peptidase family M49	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M49
k59_709487_1	1120983.KB894571_gene2249	1.99e-117	350.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,1JPP0@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA,TctB
k59_1707420_1	158500.BV97_04310	2.23e-86	268.0	COG3385@1|root,COG3385@2|Bacteria,1PHKQ@1224|Proteobacteria,2VGVZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_1472992_1	1035308.AQYY01000001_gene3462	6.89e-36	136.0	COG1266@1|root,COG1266@2|Bacteria,1VCI6@1239|Firmicutes,24VQT@186801|Clostridia	186801|Clostridia	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
k59_1002403_1	1123503.KB908056_gene2109	1.37e-05	44.3	COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2UF4N@28211|Alphaproteobacteria,2KHAU@204458|Caulobacterales	204458|Caulobacterales	S	Belongs to the UPF0434 family	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
k59_1002403_2	460265.Mnod_5189	1.26e-28	110.0	COG2802@1|root,COG2802@2|Bacteria,1NV9N@1224|Proteobacteria,2TQZ4@28211|Alphaproteobacteria,1JTFK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Peptidase S16, lon domain protein	lonD	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
k59_1531133_1	1538295.JY96_20985	3.57e-101	306.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,2VKXP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
k59_1649015_1	1122194.AUHU01000011_gene1704	1.15e-69	236.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,464J4@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_888141_1	335543.Sfum_1546	4e-114	332.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,42MZP@68525|delta/epsilon subdivisions,2WJ1Z@28221|Deltaproteobacteria,2MQWW@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_181175_1	1386089.N865_12105	5.3e-142	413.0	COG0366@1|root,COG0366@2|Bacteria,2GJKR@201174|Actinobacteria,4FEN2@85021|Intrasporangiaceae	201174|Actinobacteria	G	Glycogen debranching enzyme, glucanotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Malt_amylase_C
k59_241005_1	247634.GPB2148_1175	1.91e-30	118.0	COG3633@1|root,COG3633@2|Bacteria,1MXE1@1224|Proteobacteria,1RP9B@1236|Gammaproteobacteria,1J4YA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)	sstT	GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005295,GO:0005310,GO:0005342,GO:0005343,GO:0005416,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006835,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015081,GO:0015171,GO:0015175,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015672,GO:0015711,GO:0015804,GO:0015849,GO:0016020,GO:0016021,GO:0017153,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0032329,GO:0034220,GO:0035725,GO:0044425,GO:0044464,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1903825,GO:1905039	-	ko:K07862	-	-	-	-	ko00000,ko02000	2.A.23.4	-	iAF1260.b3089,iBWG_1329.BWG_2799,iECDH10B_1368.ECDH10B_3265,iECDH1ME8569_1439.ECDH1ME8569_2984,iECH74115_1262.ECH74115_4404,iECIAI1_1343.ECIAI1_3235,iECO103_1326.ECO103_3834,iECO111_1330.ECO111_3911,iECO26_1355.ECO26_4192,iECP_1309.ECP_3180,iECSE_1348.ECSE_3370,iECSP_1301.ECSP_4063,iECUMN_1333.ECUMN_3573,iECW_1372.ECW_m3356,iECs_1301.ECs3971,iEKO11_1354.EKO11_0630,iETEC_1333.ETEC_3359,iEcDH1_1363.EcDH1_0612,iEcE24377_1341.EcE24377A_3557,iG2583_1286.G2583_3813,iJO1366.b3089,iJR904.b3089,iSFV_1184.SFV_3130,iSSON_1240.SSON_3242,iUMNK88_1353.UMNK88_3845,iWFL_1372.ECW_m3356,iY75_1357.Y75_RS16050,iYL1228.KPN_03517,iZ_1308.Z4442	SDF
k59_241005_2	1265313.HRUBRA_02126	9.58e-17	80.5	COG4774@1|root,COG4774@2|Bacteria,1RBVQ@1224|Proteobacteria,1SMVM@1236|Gammaproteobacteria,1J8EM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	Plug
k59_359817_1	497964.CfE428DRAFT_6160	6.45e-39	135.0	COG1853@1|root,COG1853@2|Bacteria,46TTE@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
k59_1649027_1	1121405.dsmv_3573	4.55e-61	191.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria,2MHKK@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_1827380_1	981369.JQMJ01000003_gene7389	5e-72	223.0	COG2326@1|root,COG2326@2|Bacteria,2GKRN@201174|Actinobacteria,2NGIJ@228398|Streptacidiphilus	201174|Actinobacteria	S	Polyphosphate kinase 2 (PPK2)	ppk2	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005525,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006183,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030808,GO:0031323,GO:0031326,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046777,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051704,GO:0055086,GO:0062012,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0080090,GO:0090407,GO:0097159,GO:0097367,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
k59_947040_1	1244869.H261_16867	9.43e-78	244.0	COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,2TS2G@28211|Alphaproteobacteria,2JQ5C@204441|Rhodospirillales	204441|Rhodospirillales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_integrase
k59_1299255_1	768671.ThimaDRAFT_2387	8.45e-26	108.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1WW2F@135613|Chromatiales	135613|Chromatiales	P	Chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
k59_1765868_1	1121405.dsmv_3053	1.31e-86	283.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2WIVR@28221|Deltaproteobacteria,2MI3P@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_7100_1	1279017.AQYJ01000029_gene3424	4.23e-102	311.0	COG1835@1|root,COG1835@2|Bacteria,1R4CU@1224|Proteobacteria,1T1DB@1236|Gammaproteobacteria,4670I@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_241022_1	870187.Thini_4139	1.64e-97	287.0	COG2860@1|root,COG2860@2|Bacteria,1R9H8@1224|Proteobacteria,1S00T@1236|Gammaproteobacteria,461SI@72273|Thiotrichales	72273|Thiotrichales	S	UPF0126 domain	-	-	-	-	-	-	-	-	-	-	-	-	UPF0126
k59_1238105_1	1280001.BAOA01000138_gene1985	1.52e-12	69.3	COG3659@1|root,COG3659@2|Bacteria,1R8TI@1224|Proteobacteria,1S21B@1236|Gammaproteobacteria,1XVR4@135623|Vibrionales	135623|Vibrionales	M	Carbohydrate-selective porin, OprB family	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB
k59_1531151_1	768671.ThimaDRAFT_2670	2.61e-56	186.0	COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,1RRKZ@1236|Gammaproteobacteria,1WWQA@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
k59_181191_1	439235.Dalk_1467	1.06e-82	263.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria	1224|Proteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_122468_1	765910.MARPU_08895	5.55e-91	283.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1WW67@135613|Chromatiales	135613|Chromatiales	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_66365_1	1304865.JAGF01000001_gene3656	9.2e-34	127.0	COG0457@1|root,COG0457@2|Bacteria,2GKX5@201174|Actinobacteria,4F19B@85016|Cellulomonadaceae	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
k59_181194_1	269799.Gmet_2366	1.42e-30	119.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,42MKD@68525|delta/epsilon subdivisions,2WIZP@28221|Deltaproteobacteria,43U2J@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_359850_1	948565.AFFP02000023_gene1531	2.22e-47	163.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1Y74H@135625|Pasteurellales	135625|Pasteurellales	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_888175_1	713586.KB900536_gene590	7.96e-64	209.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,1RR7X@1236|Gammaproteobacteria,1WW9A@135613|Chromatiales	135613|Chromatiales	G	PFAM carbohydrate kinase	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
k59_888175_2	472759.Nhal_1446	9.7e-74	222.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,1TJD2@1236|Gammaproteobacteria,1WYEP@135613|Chromatiales	135613|Chromatiales	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
k59_888175_3	713586.KB900536_gene592	9.15e-145	445.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1WW7V@135613|Chromatiales	135613|Chromatiales	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_66383_1	1123065.ATWL01000002_gene1717	2.25e-134	400.0	COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria	201174|Actinobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_533517_1	1282361.ABAC402_16310	4.01e-28	111.0	COG0647@1|root,COG0647@2|Bacteria,1MU9Y@1224|Proteobacteria,2TUH0@28211|Alphaproteobacteria,2KF3K@204458|Caulobacterales	204458|Caulobacterales	G	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
k59_415808_1	870187.Thini_2905	1.12e-96	304.0	COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,1RN9V@1236|Gammaproteobacteria,460AS@72273|Thiotrichales	72273|Thiotrichales	C	radical SAM protein YgiQ	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
k59_1707452_1	439235.Dalk_5190	2.72e-64	212.0	COG3547@1|root,COG3547@2|Bacteria,1NCHY@1224|Proteobacteria,42TM4@68525|delta/epsilon subdivisions,2WR4U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1649056_1	502025.Hoch_4315	2.22e-14	72.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42M0A@68525|delta/epsilon subdivisions,2WIQY@28221|Deltaproteobacteria,2YTUC@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787,ko:K15726	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.2,2.A.6.1.4	-	-	ACR_tran
k59_1649056_2	1297742.A176_03032	1.83e-24	103.0	COG0845@1|root,COG0845@2|Bacteria,1MX8W@1224|Proteobacteria,42SYF@68525|delta/epsilon subdivisions,2WPNQ@28221|Deltaproteobacteria,2YZZ6@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
k59_1002438_1	1249627.D779_0628	5.99e-121	356.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,1WX6R@135613|Chromatiales	135613|Chromatiales	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_474728_1	398767.Glov_2183	1.14e-76	238.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,42NPN@68525|delta/epsilon subdivisions,2WIY4@28221|Deltaproteobacteria,43U3I@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Polyprenyl synthetase	ispA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K00795,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_1649058_1	765913.ThidrDRAFT_0973	2.87e-45	151.0	COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,1S5X6@1236|Gammaproteobacteria,1WY50@135613|Chromatiales	135613|Chromatiales	T	low molecular weight	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
k59_888190_1	590998.Celf_2343	8.86e-151	446.0	COG1506@1|root,COG1506@2|Bacteria,2I2K7@201174|Actinobacteria,4F0GK@85016|Cellulomonadaceae	201174|Actinobacteria	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	BAAT_C,Peptidase_S9
k59_826690_1	748658.KB907317_gene268	4.02e-51	170.0	COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,1T20F@1236|Gammaproteobacteria,1WW2D@135613|Chromatiales	135613|Chromatiales	E	PFAM Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
k59_826690_2	440512.C211_02136	9.12e-18	82.0	COG0128@1|root,COG0287@1|root,COG0128@2|Bacteria,COG0287@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	1.3.1.12,1.3.1.43,2.5.1.19	ko:K00210,ko:K00220,ko:K00800	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00022,M00025,M00040	R00732,R01728,R03460	RC00125,RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase,PDH
k59_1589674_1	261292.Nit79A3_3271	1.22e-75	234.0	28JXP@1|root,2Z9N4@2|Bacteria,1MXG4@1224|Proteobacteria,2WBED@28216|Betaproteobacteria,372YW@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C92
k59_533527_1	1117647.M5M_17530	1.94e-37	134.0	COG3028@1|root,COG3028@2|Bacteria,1MZ4R@1224|Proteobacteria,1S9JJ@1236|Gammaproteobacteria,1J6MQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the UPF0307 family	yjgA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K09889	-	-	-	-	ko00000,ko03009	-	-	-	DUF615
k59_1531875_2	396014.BF93_18585	4.55e-22	87.4	COG1837@1|root,COG1837@2|Bacteria,2IQ4C@201174|Actinobacteria,4FD4M@85020|Dermabacteraceae	201174|Actinobacteria	S	KH domain	-	GO:0008150,GO:0040007	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
k59_827453_1	861299.J421_1491	1.22e-74	239.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1ZSZ7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	CE	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3
k59_827453_2	267608.RSc2911	1.49e-33	122.0	COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,2VRXM@28216|Betaproteobacteria,1K7E8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	ybak prolyl-trna synthetase associated region	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
k59_1828481_2	1440052.EAKF1_ch2993	6.96e-12	67.0	COG4795@1|root,COG4795@2|Bacteria,1RJAE@1224|Proteobacteria,1S5ZZ@1236|Gammaproteobacteria,3XPFX@561|Escherichia	1236|Gammaproteobacteria	U	Type II secretion system (T2SS), protein J	gspJ	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSJ
k59_768105_1	864702.OsccyDRAFT_1593	1.53e-26	105.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_768105_2	290397.Adeh_0929	1.26e-05	47.4	COG0003@1|root,COG0003@2|Bacteria,1NA7C@1224|Proteobacteria,42V2J@68525|delta/epsilon subdivisions,2WS25@28221|Deltaproteobacteria,2YUZS@29|Myxococcales	28221|Deltaproteobacteria	P	Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
k59_889251_1	935557.ATYB01000014_gene2694	1.61e-11	65.5	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,2TRF9@28211|Alphaproteobacteria,4B98B@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Phosphate	yjbB	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
k59_827460_2	1245475.ANAE01000067_gene3696	3.2e-32	117.0	COG0640@1|root,COG0640@2|Bacteria,2IQ55@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
k59_416568_1	768671.ThimaDRAFT_4548	4.99e-56	185.0	COG1073@1|root,COG1073@2|Bacteria,1R76C@1224|Proteobacteria,1RR34@1236|Gammaproteobacteria,1X0RN@135613|Chromatiales	135613|Chromatiales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
k59_1649785_1	367299.JOEE01000004_gene998	2.65e-41	140.0	COG0711@1|root,COG0711@2|Bacteria,2GJS4@201174|Actinobacteria,4FGEP@85021|Intrasporangiaceae	201174|Actinobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
k59_1649785_2	313589.JNB_07034	1.27e-37	126.0	COG0636@1|root,COG0636@2|Bacteria,2GQI6@201174|Actinobacteria,4FHQR@85021|Intrasporangiaceae	201174|Actinobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_1649785_3	1193181.BN10_1140011	5.09e-11	61.6	COG0356@1|root,COG0356@2|Bacteria,2H3PR@201174|Actinobacteria,4FG1G@85021|Intrasporangiaceae	201174|Actinobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_360911_1	1380370.JIBA01000014_gene1796	5.3e-69	225.0	COG2385@1|root,COG2385@2|Bacteria,2I3WB@201174|Actinobacteria,4FI8C@85021|Intrasporangiaceae	201174|Actinobacteria	D	sporulation resulting in formation of a cellular spore	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
k59_1474092_1	367299.JOEE01000003_gene2733	3.66e-112	335.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4FERU@85021|Intrasporangiaceae	201174|Actinobacteria	H	Folylpolyglutamate synthase	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2447c	Mur_ligase_C,Mur_ligase_M
k59_67462_1	1167006.UWK_02393	5.48e-62	207.0	COG1624@1|root,COG4856@1|root,COG1624@2|Bacteria,COG4856@2|Bacteria,1PEQT@1224|Proteobacteria,42P5A@68525|delta/epsilon subdivisions,2WKPP@28221|Deltaproteobacteria,2MIQR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	-	-	-	-	-	-	-	-	-	-	DisA_N,YbbR
k59_299514_1	1380391.JIAS01000020_gene1407	9.49e-95	290.0	COG2271@1|root,COG2271@2|Bacteria,1QVY6@1224|Proteobacteria,2TVPK@28211|Alphaproteobacteria,2JZ3A@204441|Rhodospirillales	204441|Rhodospirillales	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1828515_1	153948.NAL212_0727	2.59e-58	187.0	COG4974@1|root,COG4974@2|Bacteria,1MZES@1224|Proteobacteria,2VU6S@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Plasmid pRiA4b	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
k59_889273_1	406817.XNC1_0716	4.18e-49	169.0	COG3039@1|root,COG3039@2|Bacteria,1MXP1@1224|Proteobacteria,1RSBM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	There are 9 addittional ORFs identical to this one	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_3
k59_1649798_1	247634.GPB2148_793	4.6e-106	316.0	COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,1RQBF@1236|Gammaproteobacteria,1J62W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the peptidase S11 family	pbpG	GO:0003674,GO:0003824,GO:0004175,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K07262	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
k59_710284_1	314271.RB2654_09079	1.56e-173	514.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1042 Acyl-CoA synthetase (NDP forming)	MA20_38090	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1003050_1	743718.Isova_2877	2.58e-11	62.4	COG1266@1|root,COG1266@2|Bacteria,2GK11@201174|Actinobacteria,4F3D8@85017|Promicromonosporaceae	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_1003050_2	1304865.JAGF01000001_gene1353	7.6e-59	201.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4F0GR@85016|Cellulomonadaceae	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_534304_1	56780.SYN_00285	3.73e-30	118.0	COG0845@1|root,COG0845@2|Bacteria,1PZST@1224|Proteobacteria,42R2S@68525|delta/epsilon subdivisions,2WMVJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	TIGRFAM efflux transporter, RND family, MFP subunit	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3
k59_534304_2	748247.AZKH_1670	1.22e-58	203.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2VKF8@28216|Betaproteobacteria	28216|Betaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_1590373_2	1151119.KB895498_gene3581	1.95e-13	70.5	COG3386@1|root,COG3386@2|Bacteria,2HDRT@201174|Actinobacteria	201174|Actinobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	SGL
k59_360943_1	1500894.JQNN01000001_gene225	2.56e-64	220.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2VIK1@28216|Betaproteobacteria,472FY@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Putative peptidoglycan binding domain	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
k59_1531914_2	1384056.N787_09380	5.94e-17	75.9	COG1714@1|root,COG1714@2|Bacteria,1MZAD@1224|Proteobacteria,1S6E9@1236|Gammaproteobacteria,1X8JP@135614|Xanthomonadales	135614|Xanthomonadales	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,RDD
k59_1649809_1	367299.JOEE01000006_gene698	8.21e-145	410.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4FEUK@85021|Intrasporangiaceae	201174|Actinobacteria	T	XRE family transcriptional regulator	regX3	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1649809_2	1184607.AUCHE_08_00690	2e-21	93.2	COG5002@1|root,COG5002@2|Bacteria,2GJY7@201174|Actinobacteria,4F6NW@85018|Dermatophilaceae	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	senX3	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:1901564	2.7.13.3	ko:K07768	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_710300_1	1232410.KI421422_gene2086	7.78e-115	354.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TIGRFAM TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1003064_1	391595.RLO149_c005830	4.7e-117	346.0	COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,2TRWC@28211|Alphaproteobacteria,2P2JP@2433|Roseobacter	28211|Alphaproteobacteria	E	Conserved region in glutamate synthase	glxD	-	2.1.1.21	ko:K22083	ko00680,ko01120,map00680,map01120	-	R01586	RC00554	ko00000,ko00001,ko01000	-	-	-	Glu_synthase
k59_827498_1	1713.JOFV01000007_gene2975	1.54e-114	353.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4F0QU@85016|Cellulomonadaceae	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
k59_1828548_2	314345.SPV1_08091	2.08e-21	90.1	COG4764@1|root,COG4764@2|Bacteria,1MVRK@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_948225_1	1265313.HRUBRA_02856	2.56e-38	132.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S8RS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	biopolymer transport protein	tolR	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032153,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
k59_948225_2	1026882.MAMP_00019	1.87e-24	97.8	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,460DQ@72273|Thiotrichales	72273|Thiotrichales	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
k59_1179889_1	290398.Csal_2139	4.68e-81	258.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1XHB9@135619|Oceanospirillales	135619|Oceanospirillales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_1415001_1	382464.ABSI01000012_gene2146	8.31e-28	116.0	COG1593@1|root,COG1593@2|Bacteria	2|Bacteria	G	mannitol 2-dehydrogenase activity	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM,DctQ
k59_1474160_2	1123502.AQXD01000001_gene1101	2.24e-30	115.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,1RNJW@1236|Gammaproteobacteria,1X73J@135614|Xanthomonadales	135614|Xanthomonadales	Q	ABC-type transport system involved in resistance to organic solvents auxiliary component	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
k59_1003076_1	1121405.dsmv_3247	1.52e-21	91.7	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,42MHX@68525|delta/epsilon subdivisions,2WIKS@28221|Deltaproteobacteria,2MI6H@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_1003076_2	1458462.JNLK01000001_gene2800	3.25e-22	95.1	COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,247PP@186801|Clostridia,27IWC@186928|unclassified Lachnospiraceae	186801|Clostridia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
k59_948244_1	452637.Oter_2678	5.13e-96	303.0	COG0542@1|root,COG0542@2|Bacteria,46SD6@74201|Verrucomicrobia,3K7MH@414999|Opitutae	414999|Opitutae	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
k59_827516_1	590998.Celf_1697	1.78e-109	328.0	COG0520@1|root,COG0520@2|Bacteria,2GIVK@201174|Actinobacteria,4F11T@85016|Cellulomonadaceae	201174|Actinobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
k59_1828581_1	66373.JOFQ01000022_gene6459	3.01e-16	78.2	COG1670@1|root,COG1670@2|Bacteria,2GP87@201174|Actinobacteria	201174|Actinobacteria	J	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_948255_1	1304865.JAGF01000001_gene3613	2.85e-16	76.3	COG1309@1|root,COG1309@2|Bacteria,2IQGF@201174|Actinobacteria,4F2YR@85016|Cellulomonadaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_416629_1	314278.NB231_11044	1.35e-113	343.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1WWEC@135613|Chromatiales	135613|Chromatiales	S	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
k59_8665_1	1000565.METUNv1_01232	1.09e-100	300.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,2VJQG@28216|Betaproteobacteria,2KUXA@206389|Rhodocyclales	206389|Rhodocyclales	H	Bacterial extracellular solute-binding protein	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
k59_710330_2	236097.ADG881_1754	1.81e-46	157.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,1S22U@1236|Gammaproteobacteria,1XN5N@135619|Oceanospirillales	135619|Oceanospirillales	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1300459_1	37919.EP51_23920	2.81e-09	68.2	COG0515@1|root,COG2197@1|root,COG3903@1|root,COG0515@2|Bacteria,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4FUTU@85025|Nocardiaceae	201174|Actinobacteria	K	activity, protein serine threonine kinase activity, protein-tyrosine kinase activity, ATP binding, regulation of transcription, DNA-dependent, protein amino acid phosphorylation	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,GerE,NB-ARC,Pkinase,TPR_12
k59_534357_1	1158146.KB907123_gene746	4.66e-35	135.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1WVWG@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
k59_8681_1	1168067.JAGP01000001_gene610	2.76e-37	133.0	COG1416@1|root,COG1416@2|Bacteria,1N0U1@1224|Proteobacteria,1SGKY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DsrE/DsrF-like family	-	-	-	ko:K09004	-	-	-	-	ko00000	-	-	-	DrsE
k59_8681_2	396588.Tgr7_3057	1.37e-41	152.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales	135613|Chromatiales	I	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_1063138_1	408672.NBCG_02518	1.35e-74	245.0	COG3345@1|root,COG3345@2|Bacteria,2GJJ1@201174|Actinobacteria,4DSZC@85009|Propionibacteriales	201174|Actinobacteria	G	Glycosyl hydrolase family 36 N-terminal domain	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
k59_1003098_2	1249627.D779_2942	8.64e-07	52.8	2C9YT@1|root,31Z2V@2|Bacteria,1RHIU@1224|Proteobacteria,1S6G3@1236|Gammaproteobacteria,1WYT4@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1356006_1	1713.JOFV01000016_gene16	1.06e-228	650.0	COG1882@1|root,COG1882@2|Bacteria,2GTTT@201174|Actinobacteria,4F0Z2@85016|Cellulomonadaceae	201174|Actinobacteria	C	Pyruvate formate lyase-like	pflB	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
k59_1415041_1	391615.ABSJ01000029_gene1940	4.15e-116	367.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1J4IV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_1474211_1	1226994.AMZB01000124_gene2973	5.68e-146	434.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1YEVJ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1239274_1	452637.Oter_0894	2.7e-87	286.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,46U9T@74201|Verrucomicrobia,3K7GP@414999|Opitutae	414999|Opitutae	E	glutamate synthase	-	-	1.4.7.1	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	-	R00021,R10086	RC00006,RC00010	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_534375_1	195250.CM001776_gene3350	2.32e-50	177.0	COG0464@1|root,COG0464@2|Bacteria,1G1YA@1117|Cyanobacteria	1117|Cyanobacteria	O	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_827552_2	458817.Shal_2155	2.5e-33	124.0	COG0607@1|root,COG0607@2|Bacteria,1N9FQ@1224|Proteobacteria,1SJC3@1236|Gammaproteobacteria,2QCAA@267890|Shewanellaceae	1236|Gammaproteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_67579_1	631362.Thi970DRAFT_01073	2.34e-50	181.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,1WWWU@135613|Chromatiales	135613|Chromatiales	C	CoA-binding domain protein	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_948293_1	1331060.RLDS_11435	1.14e-63	217.0	COG4938@1|root,COG4938@2|Bacteria,1NEEG@1224|Proteobacteria,2UAZA@28211|Alphaproteobacteria,2KBCU@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF3696)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15,DUF3696
k59_1239277_1	1210046.B277_06003	5.73e-43	157.0	COG0526@1|root,COG0526@2|Bacteria,2IMCX@201174|Actinobacteria,4FH2W@85021|Intrasporangiaceae	201174|Actinobacteria	CO	Methylamine utilisation protein MauE	-	-	-	-	-	-	-	-	-	-	-	-	MauE
k59_1063162_1	1429046.RR21198_4148	1.43e-11	68.6	COG1877@1|root,COG1877@2|Bacteria,2HHMV@201174|Actinobacteria,4FZ8S@85025|Nocardiaceae	201174|Actinobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	-	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
k59_242619_1	935261.JAGL01000041_gene2588	1.04e-43	145.0	COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,2U945@28211|Alphaproteobacteria,43K7U@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
k59_242619_2	709032.Sulku_2205	3.21e-07	52.4	COG4902@1|root,COG4902@2|Bacteria,1RHUF@1224|Proteobacteria,42ZBX@68525|delta/epsilon subdivisions,2YSDR@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Uncharacterized protein domain (DUF2202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2202
k59_1239298_1	985054.JQEZ01000001_gene1923	4.59e-101	304.0	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,2TQPC@28211|Alphaproteobacteria,4NDFD@97050|Ruegeria	28211|Alphaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	ko:K18996	-	-	-	-	ko00000,ko03032	-	-	-	HTH_28,HTH_29,HTH_32,rve
k59_535020_1	105559.Nwat_1003	7.16e-14	68.9	COG1436@1|root,COG1436@2|Bacteria,1MZUE@1224|Proteobacteria,1SATX@1236|Gammaproteobacteria,1WYZV@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_F
k59_535020_2	1049564.TevJSym_ab01990	1.74e-36	127.0	COG0636@1|root,COG0636@2|Bacteria,1REA9@1224|Proteobacteria,1S51I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
k59_1180782_1	760011.Spico_0052	7.92e-36	139.0	COG5184@1|root,COG5492@1|root,COG5184@2|Bacteria,COG5492@2|Bacteria,2J8DW@203691|Spirochaetes	203691|Spirochaetes	DZ	COGs COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Flg_new,Mfa_like_1,RCC1,RCC1_2
k59_1301458_1	349124.Hhal_0608	1.8e-74	227.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,1S23B@1236|Gammaproteobacteria,1WXV9@135613|Chromatiales	135613|Chromatiales	S	Belongs to the WrbA family	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
k59_362045_1	1123401.JHYQ01000027_gene3115	4.37e-81	246.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria,460CA@72273|Thiotrichales	72273|Thiotrichales	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_362045_2	1068978.AMETH_2637	3.5e-67	207.0	COG0328@1|root,COG0328@2|Bacteria,2GK53@201174|Actinobacteria,4E30W@85010|Pseudonocardiales	201174|Actinobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
k59_890311_1	686340.Metal_3276	1.34e-53	174.0	2DKVG@1|root,30GRY@2|Bacteria,1RDQT@1224|Proteobacteria,1S80C@1236|Gammaproteobacteria,1XFEZ@135618|Methylococcales	135618|Methylococcales	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
k59_949269_1	111781.Lepto7376_2432	2.72e-78	253.0	COG0480@1|root,COG0480@2|Bacteria,1G1KG@1117|Cyanobacteria,1H7SY@1150|Oscillatoriales	1117|Cyanobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_476240_1	446469.Sked_32650	7.54e-108	319.0	COG4632@1|root,COG4632@2|Bacteria	2|Bacteria	-	-	XK27_08080	-	3.1.1.53	ko:K05970	-	-	-	-	ko00000,ko01000	-	-	-	NAGPA
k59_476240_2	446469.Sked_32660	2.96e-114	342.0	COG1215@1|root,COG2246@1|root,COG1215@2|Bacteria,COG2246@2|Bacteria,2I6D1@201174|Actinobacteria	201174|Actinobacteria	M	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
k59_1829619_1	471854.Dfer_5258	9.82e-59	194.0	COG0673@1|root,COG0673@2|Bacteria,4NN43@976|Bacteroidetes,47UBC@768503|Cytophagia	976|Bacteroidetes	Q	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_1829619_2	1396418.BATQ01000012_gene4393	6.74e-06	47.0	COG1621@1|root,COG1621@2|Bacteria,46T0U@74201|Verrucomicrobia	74201|Verrucomicrobia	G	beta-fructofuranosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_182820_1	1121405.dsmv_2192	7.42e-73	238.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,42N42@68525|delta/epsilon subdivisions,2WK62@28221|Deltaproteobacteria,2MI73@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
k59_652475_1	1121405.dsmv_2651	2.33e-46	165.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales	68525|delta/epsilon subdivisions	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1532654_1	768671.ThimaDRAFT_1294	1.38e-33	128.0	COG3001@1|root,COG3001@2|Bacteria,1MVHX@1224|Proteobacteria,1RRC5@1236|Gammaproteobacteria,1WXE3@135613|Chromatiales	135613|Chromatiales	G	PFAM Fructosamine	-	-	-	-	-	-	-	-	-	-	-	-	Fructosamin_kin
k59_68591_1	1535422.ND16A_0548	4.03e-124	371.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,1RQK5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_1240288_1	765914.ThisiDRAFT_0027	2.27e-10	58.2	COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S4CZ@1236|Gammaproteobacteria,1WY6S@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_1240288_2	314278.NB231_13331	2.14e-47	155.0	COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,1S5UT@1236|Gammaproteobacteria,1WYJQ@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_1240288_3	1122134.KB893650_gene178	9.04e-20	89.4	COG0835@1|root,COG0835@2|Bacteria,1RCIR@1224|Proteobacteria,1SATV@1236|Gammaproteobacteria,1XRB5@135619|Oceanospirillales	135619|Oceanospirillales	NT	Two component signalling adaptor domain	-	-	-	ko:K02659	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	CheW
k59_535042_1	686340.Metal_3114	5.48e-13	67.0	COG0494@1|root,COG0494@2|Bacteria,1RDMW@1224|Proteobacteria,1RPZV@1236|Gammaproteobacteria,1XEY6@135618|Methylococcales	135618|Methylococcales	L	NUDIX domain	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_535042_2	665952.HMPREF1015_00577	2.1e-09	58.2	COG1028@1|root,COG1028@2|Bacteria,1TPDB@1239|Firmicutes,4HAKR@91061|Bacilli,1ZDEP@1386|Bacillus	91061|Bacilli	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fadH	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
k59_476245_1	1267005.KB911257_gene726	1.24e-130	381.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2TSGT@28211|Alphaproteobacteria,3N6G5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	acetylornithine	argD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_68605_1	909663.KI867150_gene1871	2.46e-79	250.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,42N63@68525|delta/epsilon subdivisions,2WJPA@28221|Deltaproteobacteria,2MQRM@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM nickel-dependent hydrogenase, large subunit	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_1121072_1	1448139.AI20_14245	3.99e-73	235.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1Y3XY@135624|Aeromonadales	135624|Aeromonadales	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K10912	ko02020,ko02024,ko05111,map02020,map02024,map05111	M00513	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1591118_1	396588.Tgr7_2744	4.89e-99	311.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales	135613|Chromatiales	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_362090_1	1380386.JIAW01000017_gene3183	4.57e-63	215.0	COG0451@1|root,COG1004@1|root,COG0451@2|Bacteria,COG1004@2|Bacteria,2GJQB@201174|Actinobacteria,23F7C@1762|Mycobacteriaceae	201174|Actinobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	tuaD	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd,UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_476257_1	1348657.M622_13650	1.28e-68	233.0	COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,2WGS4@28216|Betaproteobacteria,2KU8N@206389|Rhodocyclales	206389|Rhodocyclales	C	Molydopterin dinucleotide binding domain	-	-	1.17.99.2	ko:K10700,ko:K17050	ko00642,ko01100,ko01120,ko01220,map00642,map01100,map01120,map01220	-	R05745	RC00275	ko00000,ko00001,ko01000,ko02000	5.A.3.8,5.A.3.9	-	-	Molybdopterin,Molydop_binding
k59_1356732_1	1366046.HIMB11_01903	5.76e-129	377.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2TT5Y@28211|Alphaproteobacteria,3ZI1D@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	MA20_43200	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
k59_1003731_1	717785.HYPMC_4536	7.58e-25	103.0	2EY8I@1|root,33RH3@2|Bacteria,1NS5H@1224|Proteobacteria,2UP0R@28211|Alphaproteobacteria,3N86N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1064175_1	1268237.G114_07244	1.74e-61	204.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RQ36@1236|Gammaproteobacteria,1Y3TY@135624|Aeromonadales	135624|Aeromonadales	L	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K05591	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DEAD,DbpA,Helicase_C
k59_243993_1	1121374.KB891585_gene2368	4.8e-125	362.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,1RMAX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
k59_1591125_1	1123393.KB891316_gene2118	9.29e-34	121.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,2VJZE@28216|Betaproteobacteria,1KRWV@119069|Hydrogenophilales	119069|Hydrogenophilales	H	5-formyltetrahydrofolate cyclo-ligase family	-	-	-	-	-	-	-	-	-	-	-	-	5-FTHF_cyc-lig
k59_1591125_2	400682.PAC_15709291	2.16e-40	137.0	COG2947@1|root,KOG3383@2759|Eukaryota,39R2K@33154|Opisthokonta,3B9WQ@33208|Metazoa	33208|Metazoa	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
k59_1415847_1	1122169.AREN01000059_gene298	1.21e-15	82.4	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1JCAM@118969|Legionellales	118969|Legionellales	CO	Cytochrome C biogenesis protein transmembrane region	dsbD_2	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbD,Thioredoxin_7
k59_652500_1	471853.Bcav_2099	3.79e-61	192.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	merR2	-	-	-	-	-	-	-	-	-	-	-	MerR_1
k59_652500_2	1304865.JAGF01000001_gene3141	3.34e-125	388.0	COG1038@1|root,COG1038@2|Bacteria,2H238@201174|Actinobacteria,4F1VZ@85016|Cellulomonadaceae	201174|Actinobacteria	C	Conserved carboxylase domain	pyc	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA
k59_244001_1	56780.SYN_02767	1.93e-54	179.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,42MI2@68525|delta/epsilon subdivisions,2WJ5W@28221|Deltaproteobacteria,2MR0A@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2848	Pribosyl_synth,Pribosyltran_N
k59_593684_1	1249634.D781_4138	5.3e-17	88.6	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,3ZZRB@613|Serratia	1236|Gammaproteobacteria	S	Protein of unknown function	yhdP	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_768810_1	1165841.SULAR_03817	4.67e-131	403.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2YTAQ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_1121086_1	590998.Celf_0462	6.09e-47	168.0	COG1070@1|root,COG1070@2|Bacteria,2HDA8@201174|Actinobacteria	201174|Actinobacteria	G	PFAM carbohydrate kinase	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
k59_1475317_1	596154.Alide2_4290	1.94e-130	388.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEM@28216|Betaproteobacteria,4ABKM@80864|Comamonadaceae	28216|Betaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1829679_1	1123228.AUIH01000008_gene2428	5.74e-57	199.0	COG2807@1|root,COG2807@2|Bacteria,1NXQ2@1224|Proteobacteria,1RXXM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1708856_1	585529.HMPREF0291_11833	0.000198	43.1	COG0055@1|root,COG0055@2|Bacteria,2GIY6@201174|Actinobacteria,22KGX@1653|Corynebacteriaceae	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1708856_2	765910.MARPU_00575	3.61e-93	279.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1WW4K@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_1356751_1	396595.TK90_1168	2.49e-38	135.0	COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,1RMYH@1236|Gammaproteobacteria,1WWPD@135613|Chromatiales	135613|Chromatiales	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
k59_1356751_2	317025.Tcr_0741	6.63e-26	98.6	COG1987@1|root,COG1987@2|Bacteria,1N73W@1224|Proteobacteria,1SCBG@1236|Gammaproteobacteria,4617Z@72273|Thiotrichales	72273|Thiotrichales	N	Role in flagellar biosynthesis	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
k59_68647_1	526222.Desal_2995	1.35e-38	142.0	COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,42MQ1@68525|delta/epsilon subdivisions,2WJII@28221|Deltaproteobacteria,2M9HZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
k59_68647_2	573370.DMR_31790	4.74e-17	81.3	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,42MR9@68525|delta/epsilon subdivisions,2WIP3@28221|Deltaproteobacteria,2M9A1@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Glycine cleavage system	gcvP	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5,GDC-P
k59_124144_1	1249627.D779_0958	1.68e-96	306.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,1RPDC@1236|Gammaproteobacteria,1WWR8@135613|Chromatiales	135613|Chromatiales	S	PFAM Bacterial domain of	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
k59_828347_1	1255043.TVNIR_1954	6.24e-88	270.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_476287_1	768671.ThimaDRAFT_2039	1.4e-42	156.0	COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,1RN89@1236|Gammaproteobacteria,1WWQS@135613|Chromatiales	135613|Chromatiales	Q	PFAM Mammalian cell entry related	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_949359_1	143224.JQMD01000002_gene3059	5.61e-84	260.0	COG3367@1|root,COG3367@2|Bacteria,4NGXN@976|Bacteroidetes,1I06G@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
k59_711177_1	768671.ThimaDRAFT_0882	1.18e-52	197.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1WXQJ@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_1180873_1	593907.Celgi_2078	6.28e-69	211.0	COG0858@1|root,COG0858@2|Bacteria,2IKXP@201174|Actinobacteria,4F1A5@85016|Cellulomonadaceae	201174|Actinobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
k59_828360_1	626887.J057_04881	9e-55	179.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,464N4@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
k59_1708882_1	367299.JOEE01000006_gene853	2.11e-69	219.0	COG1432@1|root,COG1432@2|Bacteria,2HB6H@201174|Actinobacteria,4FFNZ@85021|Intrasporangiaceae	201174|Actinobacteria	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
k59_1003767_2	713586.KB900536_gene1758	2.36e-34	134.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,1WXRZ@135613|Chromatiales	135613|Chromatiales	M	PFAM AsmA family protein	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA
k59_1475365_1	177437.HRM2_39300	3.44e-78	256.0	COG1032@1|root,COG1032@2|Bacteria,1NAY8@1224|Proteobacteria,42TR8@68525|delta/epsilon subdivisions,2WQC1@28221|Deltaproteobacteria,2MMMU@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_300310_1	335543.Sfum_2611	6.35e-52	166.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,42RVK@68525|delta/epsilon subdivisions,2WNNA@28221|Deltaproteobacteria,2MRZS@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	PFAM zinc finger, DksA TraR C4-type	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
k59_300310_2	321846.PS417_04865	1.85e-09	56.2	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,1S3ST@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016043,GO:0016829,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0022607,GO:0034214,GO:0042802,GO:0043170,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0051259,GO:0061799,GO:0065003,GO:0071704,GO:0071840,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoaC
k59_300311_1	398580.Dshi_0888	1.34e-72	226.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	threonine dehydratase	tdcB	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_535108_1	454957.IA64_00290	1.36e-142	422.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1X34U@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1650709_1	365044.Pnap_0005	2.72e-21	89.0	COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,2VQBI@28216|Betaproteobacteria,4AEP7@80864|Comamonadaceae	28216|Betaproteobacteria	S	NnrU protein	nnrU	-	-	-	-	-	-	-	-	-	-	-	NnrU
k59_1650709_2	698761.RTCIAT899_CH17240	2.57e-62	207.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2TRIG@28211|Alphaproteobacteria,4B9DX@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_10302_1	1057002.KB905370_gene2611	2.09e-60	203.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_8
k59_244093_1	396595.TK90_0988	1.14e-46	165.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	zraR	GO:0000156,GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0023052,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035556,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_417429_1	1385519.N801_07200	3.23e-28	118.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria,4FEYS@85021|Intrasporangiaceae	201174|Actinobacteria	CP	cation proton antiporter	mrpD	-	-	ko:K05568,ko:K12141	-	-	-	-	ko00000,ko01000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_890453_1	743719.PaelaDRAFT_0553	6.73e-60	201.0	COG0420@1|root,COG0420@2|Bacteria,1TWMI@1239|Firmicutes,4HCA0@91061|Bacilli,26S26@186822|Paenibacillaceae	91061|Bacilli	L	DNA repair exonuclease	yhaO	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2
k59_10314_1	1249627.D779_2918	4.56e-47	163.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1WXJR@135613|Chromatiales	135613|Chromatiales	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_828384_1	314345.SPV1_07004	6.31e-67	228.0	COG0574@1|root,COG0574@2|Bacteria,1P35R@1224|Proteobacteria	1224|Proteobacteria	G	Pyruvate phosphate dikinase	-	-	-	-	-	-	-	-	-	-	-	-	LTD,PPDK_N
k59_1301595_1	935839.JAGJ01000007_gene3223	1.32e-127	389.0	COG0514@1|root,COG1040@1|root,COG0514@2|Bacteria,COG1040@2|Bacteria,2GJSS@201174|Actinobacteria,4F3KK@85017|Promicromonosporaceae	201174|Actinobacteria	L	Type III restriction enzyme, res subunit	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
k59_244110_1	95619.PM1_0200115	4.32e-65	226.0	COG0834@1|root,COG5001@1|root,COG0834@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_9,SBP_bac_3
k59_10322_2	717785.HYPMC_3218	1.84e-121	360.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2TQXC@28211|Alphaproteobacteria,3N6CX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205,1.7.1.7	ko:K00088,ko:K00364	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R01134,R08240	RC00143,RC00457,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
k59_949409_1	1095772.CAHH01000046_gene119	8.16e-89	302.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GJD0@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,PDDEXK_1,UvrD-helicase,UvrD_C
k59_949409_2	471853.Bcav_2903	4.2e-15	72.8	COG5479@1|root,COG5479@2|Bacteria,2GMJR@201174|Actinobacteria	201174|Actinobacteria	M	Protein of unknown function (DUF3152)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3152
k59_1767874_2	330214.NIDE2139	2.04e-19	85.1	COG1484@1|root,COG1484@2|Bacteria,3J0QU@40117|Nitrospirae	40117|Nitrospirae	L	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_594299_2	870187.Thini_2041	1.11e-10	67.0	COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,46095@72273|Thiotrichales	72273|Thiotrichales	D	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_829051_1	187272.Mlg_1018	5.6e-79	252.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1WXYV@135613|Chromatiales	135613|Chromatiales	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	mltF	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
k59_1830576_1	745411.B3C1_13064	4.23e-76	256.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RYP9@1236|Gammaproteobacteria,1J606@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Peptidase family M1 domain	-	-	3.4.11.14	ko:K01263	-	-	-	-	ko00000,ko01000	-	-	-	ERAP1_C,Peptidase_M1
k59_829053_1	1122599.AUGR01000015_gene2659	4.61e-60	196.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1XI6V@135619|Oceanospirillales	135619|Oceanospirillales	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_69530_1	296591.Bpro_0769	7.81e-34	128.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2VICZ@28216|Betaproteobacteria,4AC08@80864|Comamonadaceae	28216|Betaproteobacteria	M	Lipid A biosynthesis acyltransferase	htrB1	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_363031_1	477641.MODMU_0385	4.14e-16	80.5	COG3568@1|root,COG3568@2|Bacteria,2GP3V@201174|Actinobacteria,4EV2P@85013|Frankiales	201174|Actinobacteria	L	Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_363031_2	529884.Rhola_00010490	2.25e-44	145.0	COG0229@1|root,COG0229@2|Bacteria,2IHV0@201174|Actinobacteria,4FNQ7@85023|Microbacteriaceae	201174|Actinobacteria	O	SelR domain	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
k59_476914_1	1163617.SCD_n01613	3.28e-194	560.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Ferrous iron transport protein B	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_711858_1	396588.Tgr7_0902	3.53e-85	264.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1WVUR@135613|Chromatiales	135613|Chromatiales	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
k59_891269_2	1002340.AFCF01000034_gene3564	2.09e-19	89.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria	1224|Proteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
k59_418065_1	935839.JAGJ01000001_gene1201	7.91e-105	314.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,4F3EK@85017|Promicromonosporaceae	201174|Actinobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0016740,GO:0016765,GO:0016829,GO:0016846	-	ko:K10764	ko00270,ko00920,ko01100,map00270,map00920,map01100	-	R01288	RC00020,RC02848	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0391	Cys_Met_Meta_PP
k59_183573_1	713586.KB900536_gene617	3.44e-77	238.0	COG3000@1|root,COG3000@2|Bacteria,1NR7X@1224|Proteobacteria,1RQDX@1236|Gammaproteobacteria,1X1MB@135613|Chromatiales	135613|Chromatiales	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_476935_2	1150399.AQYK01000001_gene1465	1.65e-62	199.0	COG0220@1|root,COG0220@2|Bacteria,2GJ8R@201174|Actinobacteria,4FNZB@85023|Microbacteriaceae	201174|Actinobacteria	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
k59_1241275_1	396588.Tgr7_2118	9.9e-148	423.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1WWI6@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_1591800_2	1713.JOFV01000001_gene1943	1.04e-50	167.0	COG3402@1|root,COG3402@2|Bacteria,2IR88@201174|Actinobacteria,4F1EE@85016|Cellulomonadaceae	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
k59_535755_1	398580.Dshi_0943	6.77e-63	202.0	COG1266@1|root,COG1266@2|Bacteria,1MWXT@1224|Proteobacteria,2U11K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_535755_2	396588.Tgr7_2729	8.47e-29	114.0	COG0778@1|root,COG0778@2|Bacteria,1NTK9@1224|Proteobacteria,1S1PQ@1236|Gammaproteobacteria,1WY04@135613|Chromatiales	135613|Chromatiales	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_11581_1	1121918.ARWE01000001_gene3344	7.84e-25	105.0	COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,42M2C@68525|delta/epsilon subdivisions,2WIVE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
k59_1065558_1	667014.Thein_0694	7.55e-71	225.0	COG1186@1|root,COG1186@2|Bacteria,2GGX5@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_1121667_1	1121447.JONL01000002_gene1996	1.85e-92	288.0	COG4782@1|root,COG4782@2|Bacteria,1PSSD@1224|Proteobacteria,430S8@68525|delta/epsilon subdivisions,2WW3H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Alpha/beta hydrolase of unknown function (DUF900)	-	-	-	-	-	-	-	-	-	-	-	-	DUF900
k59_769377_1	457425.XNR_2397	6.93e-10	65.1	COG1215@1|root,COG1215@2|Bacteria,2GMKV@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family 2	gpgS	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	Glycos_transf_2
k59_1302448_1	270374.MELB17_12721	3.12e-14	76.3	COG3031@1|root,COG3031@2|Bacteria,1NHQ4@1224|Proteobacteria,1SHIQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Type II secretion system protein C	-	-	-	ko:K02452	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSC
k59_891299_1	1172190.M947_03260	1.09e-06	53.9	2E3AM@1|root,32YA4@2|Bacteria,1NE7S@1224|Proteobacteria,43BCG@68525|delta/epsilon subdivisions,2YT7P@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_124870_1	545264.KB898744_gene2053	3.26e-79	248.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RN5F@1236|Gammaproteobacteria,1WVWD@135613|Chromatiales	135613|Chromatiales	C	PFAM malic	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
k59_1181625_1	396588.Tgr7_1535	3.25e-94	299.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1WXK8@135613|Chromatiales	135613|Chromatiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_183592_1	472759.Nhal_1845	1.47e-94	306.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,LysM
k59_363084_1	247490.KSU1_D0896	4.82e-91	274.0	COG1215@1|root,COG1215@2|Bacteria,2IXXE@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1591808_1	199310.c3920	6.51e-149	443.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,3XN31@561|Escherichia	1236|Gammaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_418087_1	882378.RBRH_01098	6.66e-80	252.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2VI3U@28216|Betaproteobacteria,1K2CP@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_653217_1	452637.Oter_1488	3.96e-95	293.0	COG0554@1|root,COG0554@2|Bacteria,46SJW@74201|Verrucomicrobia,3K7I5@414999|Opitutae	414999|Opitutae	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_69594_1	395493.BegalDRAFT_2333	1.25e-63	202.0	COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,1S3VU@1236|Gammaproteobacteria,462D3@72273|Thiotrichales	72273|Thiotrichales	G	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	3.1.3.105	ko:K22292	ko00520,map00520	-	R11785	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_594349_1	762376.AXYL_05966	2.11e-16	79.7	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria,3T8VD@506|Alcaligenaceae	28216|Betaproteobacteria	M	Mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
k59_594349_2	207954.MED92_07906	7.63e-16	77.4	COG3235@1|root,COG3235@2|Bacteria,1RDHR@1224|Proteobacteria,1S3KS@1236|Gammaproteobacteria,1XJH0@135619|Oceanospirillales	135619|Oceanospirillales	S	Cobalt uptake substrate-specific transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CbiM
k59_1651460_1	1307759.JOMJ01000003_gene927	6.52e-109	338.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,42SZ0@68525|delta/epsilon subdivisions,2WPIR@28221|Deltaproteobacteria,2MAQX@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	DEAD-like helicase	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
k59_1476331_2	1454010.JEOE01000008_gene1867	2.87e-121	384.0	COG1524@1|root,COG1524@2|Bacteria,2GK2R@201174|Actinobacteria	201174|Actinobacteria	S	PFAM PglZ domain	pglZ	-	-	-	-	-	-	-	-	-	-	-	PglZ
k59_1121681_1	266940.Krad_1466	4.5e-122	371.0	COG1185@1|root,COG1185@2|Bacteria,2GIT2@201174|Actinobacteria	201174|Actinobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_891322_1	1121405.dsmv_2227	8.34e-127	384.0	28HQ2@1|root,2Z7XV@2|Bacteria,1P4Z7@1224|Proteobacteria,42NSG@68525|delta/epsilon subdivisions,2WJ6K@28221|Deltaproteobacteria,2MJCF@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1533399_1	582899.Hden_1847	9.04e-27	104.0	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2TU68@28211|Alphaproteobacteria,3N6QX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
k59_1533399_2	1123399.AQVE01000032_gene789	4.44e-51	174.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,460F9@72273|Thiotrichales	72273|Thiotrichales	C	Aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_300939_1	566466.NOR53_3566	2.82e-69	224.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1S01K@1236|Gammaproteobacteria,1J7W3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	L COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_69611_1	1163617.SCD_n00603	1.92e-12	67.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2VIR6@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Cytochrome C1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
k59_69611_2	754477.Q7C_2215	3.93e-168	479.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,45ZV4@72273|Thiotrichales	72273|Thiotrichales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
k59_1830674_1	543913.D521_1096	1.93e-50	162.0	COG0537@1|root,COG0537@2|Bacteria,1N3EA@1224|Proteobacteria,2VSGA@28216|Betaproteobacteria	28216|Betaproteobacteria	FG	Histidine triad (Hit) protein	-	-	-	-	-	-	-	-	-	-	-	-	HIT
k59_1830674_2	177437.HRM2_15530	3.77e-18	84.3	COG0668@1|root,COG3064@1|root,COG0668@2|Bacteria,COG3064@2|Bacteria,1N596@1224|Proteobacteria,42Z9C@68525|delta/epsilon subdivisions,2WUFQ@28221|Deltaproteobacteria,2MN3G@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel
k59_653241_1	590998.Celf_0630	8.8e-61	199.0	COG2755@1|root,COG2755@2|Bacteria,2GNBP@201174|Actinobacteria,4F0RP@85016|Cellulomonadaceae	201174|Actinobacteria	E	PFAM lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
k59_418115_1	1123060.JONP01000005_gene5562	2.32e-10	62.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,2U52Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_124916_1	1304865.JAGF01000001_gene965	1.01e-22	90.1	2EG8Z@1|root,33A0S@2|Bacteria,2I8BH@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1065659_2	1123237.Salmuc_00158	2.44e-93	281.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TSH9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
k59_477001_1	768671.ThimaDRAFT_0873	2.9e-62	208.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGB@1236|Gammaproteobacteria,1X1MI@135613|Chromatiales	135613|Chromatiales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1767965_1	1122604.JONR01000008_gene2205	1.02e-25	109.0	2DB8N@1|root,2Z7S9@2|Bacteria,1PZ8J@1224|Proteobacteria,1S1F6@1236|Gammaproteobacteria,1X62X@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF3047)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3047
k59_594377_1	1255043.TVNIR_3110	1.59e-273	781.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales	135613|Chromatiales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_1121701_1	28072.Nos7524_2080	2.69e-24	106.0	COG3033@1|root,COG3033@2|Bacteria,1G33V@1117|Cyanobacteria,1HQEM@1161|Nostocales	1117|Cyanobacteria	E	Beta-eliminating lyase	tpl	-	4.1.99.2	ko:K01668	ko00350,map00350	-	R00728	RC00355,RC00364	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_245417_1	1267003.KB911365_gene448	1.9e-11	67.8	COG0226@1|root,COG0226@2|Bacteria,1TQ5X@1239|Firmicutes,4HBEB@91061|Bacilli,3F4ER@33958|Lactobacillaceae	91061|Bacilli	P	Phosphate	pstS	GO:0003674,GO:0005488,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015698,GO:0042301,GO:0043167,GO:0043168,GO:0051179,GO:0051234	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_1181680_1	471853.Bcav_3069	1.22e-58	190.0	COG2897@1|root,COG2897@2|Bacteria,2GMDR@201174|Actinobacteria	201174|Actinobacteria	P	sulfurtransferase	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	ApbA,ApbA_C,Rhodanese
k59_245425_1	765913.ThidrDRAFT_1824	4.55e-59	198.0	COG3278@1|root,COG3278@2|Bacteria,1P8T0@1224|Proteobacteria,1T4ST@1236|Gammaproteobacteria,1WW05@135613|Chromatiales	135613|Chromatiales	O	Belongs to the heme-copper respiratory oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1416706_1	575540.Isop_3342	6.59e-45	151.0	COG1704@1|root,COG1704@2|Bacteria,2IZBC@203682|Planctomycetes	203682|Planctomycetes	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_891373_1	318464.IO99_03215	4.22e-07	53.5	COG0701@1|root,COG0701@2|Bacteria,1UZ6Z@1239|Firmicutes,25DX2@186801|Clostridia,36UFT@31979|Clostridiaceae	186801|Clostridia	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1,Fer4_13
k59_1241370_2	335283.Neut_2110	6.55e-24	99.0	COG1663@1|root,COG2835@1|root,COG1663@2|Bacteria,COG2835@2|Bacteria,1MU8G@1224|Proteobacteria,2VHPG@28216|Betaproteobacteria,372MY@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
k59_1241370_3	1163407.UU7_10346	9.27e-32	120.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1X3DM@135614|Xanthomonadales	135614|Xanthomonadales	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
k59_1065666_1	1218074.BAXZ01000009_gene2374	2.48e-55	201.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2VP95@28216|Betaproteobacteria,1K3PP@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_1,TPR_16,TPR_2,TPR_6,TPR_8
k59_1065666_2	1292034.OR37_00750	2.05e-53	201.0	COG0457@1|root,COG4424@1|root,COG0457@2|Bacteria,COG4424@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
k59_11714_1	1209072.ALBT01000031_gene1829	3.84e-16	81.6	COG3866@1|root,COG4677@1|root,COG5276@1|root,COG3866@2|Bacteria,COG4677@2|Bacteria,COG5276@2|Bacteria,1QPFF@1224|Proteobacteria,1T5VI@1236|Gammaproteobacteria,1FFY2@10|Cellvibrio	1236|Gammaproteobacteria	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	Pectinesterase
k59_11714_2	2340.JV46_12440	1.75e-39	135.0	COG1416@1|root,COG1416@2|Bacteria,1MZ46@1224|Proteobacteria,1SPBC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
k59_69662_1	1280390.CBQR020000144_gene3626	4.69e-34	119.0	COG4120@1|root,COG4120@2|Bacteria,1TPDJ@1239|Firmicutes,4HBMY@91061|Bacilli,26RIM@186822|Paenibacillaceae	91061|Bacilli	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K05832	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	BPD_transp_2
k59_1767975_1	519989.ECTPHS_02681	6.16e-35	134.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1WW09@135613|Chromatiales	135613|Chromatiales	CH	Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	-	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_11718_2	1122211.JMLW01000011_gene137	1.5e-28	109.0	COG1664@1|root,COG1664@2|Bacteria,1PDPX@1224|Proteobacteria,1S9XY@1236|Gammaproteobacteria,1XKJK@135619|Oceanospirillales	135619|Oceanospirillales	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_11718_3	998674.ATTE01000001_gene2324	9.8e-39	132.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,1S675@1236|Gammaproteobacteria,460R0@72273|Thiotrichales	72273|Thiotrichales	C	Iron--sulfur cluster insertion protein erpA	erpA	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
k59_1476402_1	1437425.CSEC_2046	3.88e-53	184.0	COG1236@1|root,COG1236@2|Bacteria,2JFRH@204428|Chlamydiae	2|Bacteria	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
k59_69667_1	768671.ThimaDRAFT_2921	1.98e-35	132.0	COG3659@1|root,COG3659@2|Bacteria,1PGW8@1224|Proteobacteria,1SHC7@1236|Gammaproteobacteria	2|Bacteria	M	Carbohydrate-selective porin, OprB family	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB,SLH
k59_950381_1	1380394.JADL01000016_gene411	1.03e-94	308.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2JQPR@204441|Rhodospirillales	204441|Rhodospirillales	EQ	Hydantoinase/oxoprolinase N-terminal region	-	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_246859_1	991905.SL003B_2899	8.29e-71	240.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria,4BPT4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_1477444_1	1169161.KB897713_gene6626	2.05e-74	241.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1831683_1	1172188.KB911825_gene3555	4.77e-27	113.0	COG0489@1|root,COG3944@1|root,COG0489@2|Bacteria,COG3944@2|Bacteria,2GJ1Y@201174|Actinobacteria,4FFZV@85021|Intrasporangiaceae	201174|Actinobacteria	DM	biosynthesis protein	wcoI	-	-	-	-	-	-	-	-	-	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
k59_1534152_1	1123514.KB905899_gene1994	1.37e-54	181.0	COG1723@1|root,COG1723@2|Bacteria,1MWYM@1224|Proteobacteria,1S0KZ@1236|Gammaproteobacteria,463AF@72273|Thiotrichales	72273|Thiotrichales	S	Uncharacterised ACR, YagE family COG1723	-	-	-	-	-	-	-	-	-	-	-	-	DUF155
k59_364137_1	1499967.BAYZ01000096_gene4315	3.46e-25	112.0	COG0421@1|root,COG0421@2|Bacteria,2NNTV@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
k59_892353_1	2340.JV46_19080	1.58e-136	414.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,1J8A6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_477732_1	1122611.KB903943_gene1420	2.78e-85	261.0	COG0294@1|root,COG0294@2|Bacteria,2GJNI@201174|Actinobacteria,4EI4C@85012|Streptosporangiales	201174|Actinobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
k59_184418_1	909613.UO65_4581	8.19e-56	186.0	COG1305@1|root,COG1305@2|Bacteria,2GN5D@201174|Actinobacteria,4DXNZ@85010|Pseudonocardiales	201174|Actinobacteria	E	Bacterial transglutaminase-like N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_1592534_1	1206731.BAGB01000058_gene3557	1.86e-31	116.0	COG3153@1|root,COG3153@2|Bacteria,2IRC9@201174|Actinobacteria,4FXQH@85025|Nocardiaceae	201174|Actinobacteria	S	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1592534_2	471853.Bcav_0858	1.21e-51	170.0	COG1945@1|root,COG1945@2|Bacteria,2GTGD@201174|Actinobacteria	201174|Actinobacteria	S	Pyruvoyl-dependent arginine decarboxylase (PvlArgDC)	-	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
k59_246881_1	886293.Sinac_6978	7.05e-98	305.0	COG0488@1|root,COG0488@2|Bacteria,2IX59@203682|Planctomycetes	203682|Planctomycetes	S	ABC transporter	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_1831701_1	1278073.MYSTI_00851	1.35e-41	152.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42QKW@68525|delta/epsilon subdivisions,2WKH1@28221|Deltaproteobacteria,2YWTQ@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1831701_2	1205753.A989_08614	0.000477	41.6	COG0684@1|root,COG0684@2|Bacteria,1RH18@1224|Proteobacteria,1RS9U@1236|Gammaproteobacteria,1X6ES@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions	rraA	-	-	ko:K02553	-	-	-	-	ko00000,ko03019	-	-	-	RraA-like
k59_1122335_1	879212.DespoDRAFT_00279	1.83e-82	259.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,2MI1E@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
k59_13206_1	331678.Cphamn1_2550	1.82e-197	558.0	COG0286@1|root,COG0286@2|Bacteria	2|Bacteria	V	site-specific DNA-methyltransferase (adenine-specific) activity	hsdM	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
k59_364155_1	1123368.AUIS01000030_gene1253	7.8e-21	85.1	COG1522@1|root,COG1522@2|Bacteria,1NC1H@1224|Proteobacteria,1SE9N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
k59_364155_2	414684.RC1_2780	6.15e-34	124.0	COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,2TRXV@28211|Alphaproteobacteria,2JQCP@204441|Rhodospirillales	204441|Rhodospirillales	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	-	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
k59_477744_1	95619.PM1_0217270	3.11e-92	276.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_1303581_1	1123514.KB905899_gene1681	3.02e-43	156.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,460CV@72273|Thiotrichales	72273|Thiotrichales	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_70672_1	525246.HMPREF0058_0741	1.9e-155	461.0	COG4626@1|root,COG4626@2|Bacteria,2GNSB@201174|Actinobacteria,4D6ZD@85005|Actinomycetales	201174|Actinobacteria	S	Terminase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_70672_2	566461.SSFG_01017	1.18e-98	313.0	2C9AC@1|root,2Z7TR@2|Bacteria,2I07F@201174|Actinobacteria	201174|Actinobacteria	S	Phage portal protein, SPP1 Gp6-like	-	-	-	-	-	-	-	-	-	-	-	-	Phage_prot_Gp6
k59_1417520_1	1265505.ATUG01000002_gene1615	2.37e-86	276.0	COG0247@1|root,COG1150@1|root,COG0247@2|Bacteria,COG1150@2|Bacteria,1MUMH@1224|Proteobacteria,42N5J@68525|delta/epsilon subdivisions,2WJ6B@28221|Deltaproteobacteria,2MJHX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_1005004_1	234267.Acid_2554	5.72e-122	364.0	COG3344@1|root,COG3344@2|Bacteria	2|Bacteria	L	reverse transcriptase	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1
k59_364164_1	1463885.KL578354_gene8771	4.22e-17	82.8	COG0365@1|root,COG1071@1|root,COG0365@2|Bacteria,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria	201174|Actinobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_364164_2	1386089.N865_18950	4.87e-24	97.4	COG0716@1|root,COG0716@2|Bacteria,2IQZD@201174|Actinobacteria,4FGUK@85021|Intrasporangiaceae	201174|Actinobacteria	C	FMN binding	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_1,Flavodoxin_5
k59_770032_1	765913.ThidrDRAFT_3533	8.57e-88	273.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1WW2V@135613|Chromatiales	135613|Chromatiales	M	zinc metalloprotease	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_1126862_2	1502852.FG94_04950	6.1e-14	74.3	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria,477ST@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_22,PMT_2
k59_835297_1	572477.Alvin_0153	2.14e-58	186.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,1WX1Y@135613|Chromatiales	135613|Chromatiales	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
k59_835297_2	450851.PHZ_c0462	8.31e-08	53.1	COG0462@1|root,COG0462@2|Bacteria,1MUV7@1224|Proteobacteria,2U5MQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Belongs to the ribose-phosphate pyrophosphokinase family	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
k59_22951_1	1496688.ER33_14825	5.39e-85	258.0	COG1028@1|root,COG1028@2|Bacteria,1GPZC@1117|Cyanobacteria,22S7T@167375|Cyanobium	1117|Cyanobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1715779_1	1049564.TevJSym_bn00140	1.15e-48	167.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1J8GA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Amidohydrolase family	pyrC	-	3.5.2.3,3.5.2.5	ko:K01465,ko:K01466	ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120	M00051,M00546	R01993,R02425	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_1715779_2	1005999.GLGR_3300	5.21e-21	89.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle	rsmD	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
k59_900468_1	1049564.TevJSym_bp00040	4.46e-77	236.0	COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria,1J5QX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Phosphoserine phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
k59_774783_1	1313304.CALK_2502	2.4e-37	142.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria	2|Bacteria	GT	kinase activity	ppsA2	-	2.7.1.40,2.7.9.2	ko:K00873,ko:K01007	ko00010,ko00230,ko00620,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map00680,map00720,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050,M00173,M00374	R00199,R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK_C,PPDK_N
k59_1598188_1	1045855.DSC_10660	2.49e-127	387.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1X5B0@135614|Xanthomonadales	135614|Xanthomonadales	I	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
k59_1598188_2	400668.Mmwyl1_3830	5.36e-22	91.3	COG5424@1|root,COG5424@2|Bacteria,1QVK0@1224|Proteobacteria,1T2JB@1236|Gammaproteobacteria,1XRX9@135619|Oceanospirillales	135619|Oceanospirillales	H	Iron-containing redox enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Haem_oxygenas_2
k59_1423536_2	999550.KI421507_gene2653	1.04e-125	360.0	COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,2VEY7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG0437 Fe-S-cluster-containing hydrogenase components 1	fdhB	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4,Fer4_11,Fer4_7
k59_1423536_3	1123401.JHYQ01000007_gene540	2.55e-34	130.0	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,1RP1B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	formate dehydrogenase	fdnI	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
k59_131836_1	349124.Hhal_0511	5.99e-11	62.4	COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,1RMEA@1236|Gammaproteobacteria,1WW11@135613|Chromatiales	135613|Chromatiales	N	TIGRFAM Flagellar hook-associated protein, FlgK	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
k59_131836_2	314292.VAS14_17051	8.1e-26	105.0	COG1705@1|root,COG3951@1|root,COG1705@2|Bacteria,COG3951@2|Bacteria,1MX2W@1224|Proteobacteria,1RPGY@1236|Gammaproteobacteria,1XSX3@135623|Vibrionales	135623|Vibrionales	N	Flagellar rod assembly protein muramidase FlgJ	flgJ	GO:0003674,GO:0005198	-	ko:K02395	-	-	-	-	ko00000,ko02035	-	-	-	Glucosaminidase,Rod-binding
k59_22954_1	1386089.N865_17455	2.68e-139	414.0	COG1185@1|root,COG1185@2|Bacteria,2GIT2@201174|Actinobacteria,4FER2@85021|Intrasporangiaceae	201174|Actinobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_959463_1	153948.NAL212_1666	1.39e-122	370.0	COG1484@1|root,COG4584@1|root,COG1484@2|Bacteria,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VH6U@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,rve
k59_307212_2	999541.bgla_2g01250	9.8e-28	108.0	COG2267@1|root,COG2267@2|Bacteria,1MX0N@1224|Proteobacteria,2VNV7@28216|Betaproteobacteria,1KFHK@119060|Burkholderiaceae	28216|Betaproteobacteria	I	3-oxoadipate enol-lactonase	pcaD	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4
k59_1539847_2	1049564.TevJSym_ad00430	7.97e-22	88.2	COG2212@1|root,COG2212@2|Bacteria	2|Bacteria	P	antiporter activity	mrpF	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
k59_1539847_3	1049564.TevJSym_ad00440	6.67e-38	130.0	COG1320@1|root,COG1320@2|Bacteria,1NDYS@1224|Proteobacteria,1S972@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	monovalent cation proton antiporter, MnhG PhaG subunit	-	-	-	-	-	-	-	-	-	-	-	-	PhaG_MnhG_YufB
k59_1539847_4	768671.ThimaDRAFT_1743	6.58e-27	101.0	COG1563@1|root,COG1563@2|Bacteria,1PM0Q@1224|Proteobacteria,1SR90@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Domain of unknown function (DUF4040)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4040
k59_718722_1	1385519.N801_08570	1.5e-39	158.0	COG0823@1|root,COG0823@2|Bacteria,2GMNT@201174|Actinobacteria	201174|Actinobacteria	U	Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,PD40
k59_372228_1	1386089.N865_01820	1.12e-45	162.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria	201174|Actinobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_959477_1	498761.HM1_1271	8.24e-06	48.5	COG2177@1|root,COG2177@2|Bacteria,1TPND@1239|Firmicutes,24AA6@186801|Clostridia	186801|Clostridia	D	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
k59_959477_2	1121918.ARWE01000001_gene1487	8.94e-47	159.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,42MAM@68525|delta/epsilon subdivisions,2WK4Y@28221|Deltaproteobacteria,43SBT@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	ABC transporter	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_131847_1	1249627.D779_2705	7.16e-77	244.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1WVXZ@135613|Chromatiales	135613|Chromatiales	MU	type I secretion outer membrane protein, TolC	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
k59_1076186_1	590998.Celf_3185	2.52e-70	225.0	COG1162@1|root,COG1162@2|Bacteria,2GMDX@201174|Actinobacteria	201174|Actinobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
k59_1539862_1	476272.RUMHYD_00360	3.84e-15	82.4	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,3XZ00@572511|Blautia	186801|Clostridia	C	Psort location Cytoplasmic, score 9.98	gltA	-	1.17.1.9,1.4.1.13,1.4.1.14	ko:K00123,ko:K00266	ko00250,ko00630,ko00680,ko00910,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00250,map00630,map00680,map00910,map01100,map01110,map01120,map01130,map01200,map01230	-	R00093,R00114,R00248,R00519	RC00006,RC00010,RC02796,RC02799	ko00000,ko00001,ko01000	-	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Pyr_redox_2,Pyr_redox_3
k59_78664_1	335543.Sfum_2806	1.41e-44	159.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKFQ@28221|Deltaproteobacteria,2MRGA@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_959495_1	313628.LNTAR_19802	1.04e-42	155.0	COG2974@1|root,COG2974@2|Bacteria	2|Bacteria	L	May be involved in recombination	-	-	-	ko:K03554	-	-	-	-	ko00000,ko03400	-	-	-	RdgC
k59_22986_1	526225.Gobs_2761	1.84e-68	228.0	COG1018@1|root,COG2124@1|root,COG1018@2|Bacteria,COG2124@2|Bacteria,2GJCV@201174|Actinobacteria,4ETZ7@85013|Frankiales	201174|Actinobacteria	C	Oxidoreductase FAD-binding	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,NAD_binding_1,p450
k59_483468_1	1123065.ATWL01000020_gene3561	2.39e-81	244.0	COG1507@1|root,COG1507@2|Bacteria,2I8CS@201174|Actinobacteria	201174|Actinobacteria	S	Septum formation initiator family protein	-	-	-	ko:K09009	-	-	-	-	ko00000	-	-	-	DUF501
k59_483468_2	1304865.JAGF01000001_gene329	3.06e-133	388.0	COG0248@1|root,COG0248@2|Bacteria,2GJBN@201174|Actinobacteria,4F0GD@85016|Cellulomonadaceae	201174|Actinobacteria	FP	Ppx/GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_483468_3	590998.Celf_3712	9.31e-74	225.0	COG2606@1|root,COG2606@2|Bacteria,2IIIW@201174|Actinobacteria,4F1D0@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM YbaK prolyl-tRNA synthetase associated region	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
k59_483468_4	446466.Cfla_0916	1.46e-28	114.0	COG1252@1|root,COG1252@2|Bacteria,2GJFE@201174|Actinobacteria,4F0PX@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1127379_1	471853.Bcav_2021	1.15e-111	332.0	COG0337@1|root,COG0337@2|Bacteria,2GIUZ@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
k59_1127379_2	590998.Celf_1992	5.29e-39	137.0	COG0703@1|root,COG0703@2|Bacteria,2GRFW@201174|Actinobacteria,4F198@85016|Cellulomonadaceae	201174|Actinobacteria	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
k59_718744_2	1123024.AUII01000023_gene288	1.35e-24	101.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4DY9I@85010|Pseudonocardiales	201174|Actinobacteria	E	PFAM Aminotransferase class I and II	aspB	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1423571_2	1247963.JPHU01000004_gene555	5.78e-28	106.0	COG0745@1|root,COG0745@2|Bacteria,1MWVI@1224|Proteobacteria,2TRSP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KT	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	ctrA	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K02483,ko:K13584	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_372263_1	765911.Thivi_0930	3.84e-87	261.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1WXIC@135613|Chromatiales	135613|Chromatiales	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_483473_1	1121405.dsmv_3476	2.36e-133	403.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2WJ3E@28221|Deltaproteobacteria,2MJ6A@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_2300	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1598220_2	1146883.BLASA_1224	4.01e-68	218.0	2CC93@1|root,32VVD@2|Bacteria,2IF79@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
k59_190498_2	494419.ALPM01000010_gene714	5.08e-36	126.0	COG4828@1|root,COG4828@2|Bacteria,2IQJ3@201174|Actinobacteria,1WA1U@1268|Micrococcaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1622)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1622
k59_835892_1	187272.Mlg_2753	2.37e-74	230.0	COG1418@1|root,COG1418@2|Bacteria,1RH6M@1224|Proteobacteria,1S81F@1236|Gammaproteobacteria,1X2NE@135613|Chromatiales	135613|Chromatiales	S	mRNA catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_835892_2	754477.Q7C_1790	1.24e-79	263.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,45ZWK@72273|Thiotrichales	72273|Thiotrichales	M	TIGRFAM penicillin-binding protein, 1A	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_718749_1	1278307.KB907010_gene3629	2.64e-24	104.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,2QI1W@267894|Psychromonadaceae	1236|Gammaproteobacteria	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_1539874_1	1349767.GJA_211	4.3e-07	50.4	COG0745@1|root,COG0745@2|Bacteria,1R8Y4@1224|Proteobacteria,2VJGR@28216|Betaproteobacteria,475N4@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1658396_1	243231.GSU1866	4.55e-43	155.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2WJ1C@28221|Deltaproteobacteria,43UHM@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	SMART Nucleotide binding protein, PINc	phoH1	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
k59_78687_1	95619.PM1_0222985	1.94e-20	89.7	COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	biogenesis protein	braZ	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
k59_78687_2	395493.BegalDRAFT_1783	4.75e-36	130.0	COG3198@1|root,COG3198@2|Bacteria,1N75J@1224|Proteobacteria,1SC87@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	ccoH	-	-	ko:K09926	-	-	-	-	ko00000	-	-	-	FixH
k59_1839887_2	1198232.CYCME_0386	0.0	915.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNNJ@1236|Gammaproteobacteria,4607G@72273|Thiotrichales	72273|Thiotrichales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1076224_1	1279019.ARQK01000053_gene2088	3.46e-88	263.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,1WVVY@135613|Chromatiales	135613|Chromatiales	E	imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
k59_1076224_2	572477.Alvin_0388	1.95e-58	191.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1WWQ7@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_835902_1	713587.THITH_12520	5.52e-57	188.0	COG1313@1|root,COG1313@2|Bacteria,1NZAK@1224|Proteobacteria	1224|Proteobacteria	C	radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_1485707_2	1335757.SPICUR_03355	6.61e-16	77.8	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1WW8W@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_483487_2	1117318.PRUB_07255	1.42e-103	319.0	COG3961@1|root,COG3961@2|Bacteria,1MW2F@1224|Proteobacteria,1RQFY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GH	Belongs to the TPP enzyme family	ipdC	-	4.1.1.1,4.1.1.74	ko:K01568,ko:K04103	ko00010,ko00380,ko01100,ko01110,ko01130,map00010,map00380,map01100,map01110,map01130	-	R00014,R00755,R01974	RC00027,RC00375,RC00506,RC02744	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1009784_1	367299.JOEE01000002_gene2372	6.8e-78	249.0	COG1960@1|root,COG1960@2|Bacteria,2GJIB@201174|Actinobacteria,4FEU0@85021|Intrasporangiaceae	201174|Actinobacteria	I	Butyryl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_1009784_2	1283283.ATXA01000008_gene2991	2.44e-49	159.0	2BG73@1|root,32A40@2|Bacteria,2GPJQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1774254_1	583355.Caka_2358	4.94e-43	155.0	COG3137@1|root,COG3137@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
k59_1774254_2	1120999.JONM01000002_gene951	3.12e-46	156.0	COG0204@1|root,COG0204@2|Bacteria	2|Bacteria	I	Acyl-transferase	cmk	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase,Cytidylate_kin
k59_483490_1	323261.Noc_1208	1.34e-09	58.2	28HJ1@1|root,2Z7UB@2|Bacteria,1R3FN@1224|Proteobacteria,1S37A@1236|Gammaproteobacteria,1WXEJ@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_483490_2	768671.ThimaDRAFT_1347	1.09e-72	229.0	28JVF@1|root,2Z9KD@2|Bacteria,1MXZ6@1224|Proteobacteria,1RY7E@1236|Gammaproteobacteria,1WX1M@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_424734_1	479432.Sros_0938	5.1e-28	115.0	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria,4EI3M@85012|Streptosporangiales	201174|Actinobacteria	G	Alpha-amylase domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_424734_2	1095767.CAHD01000071_gene3109	3e-186	532.0	COG0488@1|root,COG0488@2|Bacteria,2GK9S@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	yjjK	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_660215_1	1123360.thalar_02159	3.53e-94	311.0	COG2931@1|root,COG4932@1|root,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	FecR,HCBP_related,HemolysinCabind
k59_1311746_2	653045.Strvi_0225	4.44e-36	132.0	COG4641@1|root,COG4641@2|Bacteria,2H1Z7@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2
k59_1423606_1	349521.HCH_00224	2.33e-47	173.0	COG1330@1|root,COG1330@2|Bacteria,1MWTI@1224|Proteobacteria,1RNT0@1236|Gammaproteobacteria,1XHMF@135619|Oceanospirillales	135619|Oceanospirillales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity	recC	-	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
k59_23033_1	105559.Nwat_0192	6.99e-11	62.4	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,1WYU5@135613|Chromatiales	135613|Chromatiales	P	PFAM Rhodanese domain protein	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_23033_2	1419583.V466_10950	1.2e-40	146.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1YPQZ@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	C	4Fe-4S dicluster domain	glcF	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	iECABU_c1320.ECABU_c33760,iECIAI1_1343.ECIAI1_3119,iECIAI39_1322.ECIAI39_3465,iECNA114_1301.ECNA114_3053,iECP_1309.ECP_3055,iJN746.PP_3747	CCG,Fer4_7,Fer4_8
k59_1598248_1	1366050.N234_18570	1.49e-12	70.5	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VHHZ@28216|Betaproteobacteria,1JZPN@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.2.3	ko:K07812	-	-	-	-	ko00000,ko01000,ko02000	5.A.3.4	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_835918_1	935845.JADQ01000025_gene398	1.68e-51	184.0	COG1643@1|root,COG1643@2|Bacteria,1TPET@1239|Firmicutes,4HE8W@91061|Bacilli,26U7B@186822|Paenibacillaceae	91061|Bacilli	L	ATP-dependent helicase	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_774846_1	28532.XP_010525022.1	8.63e-46	159.0	COG0084@1|root,KOG3020@2759|Eukaryota,37HFB@33090|Viridiplantae,3GBJI@35493|Streptophyta,3HMZ0@3699|Brassicales	35493|Streptophyta	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
k59_1658420_1	933262.AXAM01000016_gene168	3.65e-78	237.0	COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria,2MI9K@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Gtr1/RagA G protein conserved region	mglA	GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
k59_131907_1	1449353.JQMQ01000005_gene1691	2.73e-72	229.0	COG2267@1|root,COG2267@2|Bacteria,2GN83@201174|Actinobacteria	201174|Actinobacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_256637_1	795666.MW7_2475	6.53e-15	75.1	COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,2VJ7T@28216|Betaproteobacteria,1K1P1@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Periplasmic binding protein	btuF	-	-	ko:K02016,ko:K06858	ko02010,map02010	M00240,M00241	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.13,3.A.1.14	-	-	Peripla_BP_2
k59_256637_2	1122185.N792_02575	3.89e-19	92.0	COG3725@1|root,COG3725@2|Bacteria,1MYFA@1224|Proteobacteria,1SE2J@1236|Gammaproteobacteria,1X4YH@135614|Xanthomonadales	135614|Xanthomonadales	V	Membrane protein required for beta-lactamase induction	ampE	-	-	ko:K03807	-	-	-	-	ko00000	-	-	-	CobD_Cbib
k59_719533_2	933262.AXAM01000039_gene1154	1.15e-13	65.5	2EINH@1|root,33CDW@2|Bacteria,1NN5W@1224|Proteobacteria,42XC5@68525|delta/epsilon subdivisions,2WT26@28221|Deltaproteobacteria,2MMA6@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_719533_3	933262.AXAM01000026_gene3091	8.79e-18	78.6	COG0614@1|root,COG0614@2|Bacteria,1MZ6W@1224|Proteobacteria,42W2Q@68525|delta/epsilon subdivisions,2WRCB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
k59_1312837_1	349521.HCH_06607	5.5e-38	139.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,1XH3S@135619|Oceanospirillales	135619|Oceanospirillales	G	TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM
k59_1251596_1	1068980.ARVW01000001_gene6043	9.2e-12	67.4	COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria,4DZQZ@85010|Pseudonocardiales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
k59_1321806_1	1122951.ATUE01000006_gene1338	3.24e-37	132.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,3NJ06@468|Moraxellaceae	1236|Gammaproteobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0034641,GO:0042364,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iECUMN_1333.ECUMN_1592	adh_short_C2
k59_1665646_1	396014.BF93_07865	6.1e-16	77.0	COG2255@1|root,COG2255@2|Bacteria,2GJZF@201174|Actinobacteria,4FB9V@85020|Dermabacteraceae	201174|Actinobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_1665646_2	590998.Celf_2030	2.89e-77	237.0	COG0632@1|root,COG0632@2|Bacteria,2GN17@201174|Actinobacteria,4F16C@85016|Cellulomonadaceae	201174|Actinobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009378,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
k59_1665646_3	471853.Bcav_1992	1.92e-54	177.0	COG0817@1|root,COG0817@2|Bacteria,2GJI5@201174|Actinobacteria	201174|Actinobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
k59_138752_1	1175306.GWL_42930	8e-32	116.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,2VHS6@28216|Betaproteobacteria,472RK@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_138752_2	568706.BN118_3009	4.74e-46	150.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2VU1C@28216|Betaproteobacteria,3T478@506|Alcaligenaceae	28216|Betaproteobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_138752_3	1031711.RSPO_c00480	0.000886	40.8	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2VHSD@28216|Betaproteobacteria,1K0IX@119060|Burkholderiaceae	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_1321813_1	247633.GP2143_00065	7.83e-59	204.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1J58G@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_910588_1	1049564.TevJSym_be00390	3.75e-63	208.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,1RNKP@1236|Gammaproteobacteria,1J9P0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	CAAX prenyl protease N-terminal, five membrane helices	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
k59_1494108_1	1121875.KB907546_gene2192	8.62e-51	171.0	2C0ZU@1|root,32R7S@2|Bacteria,4P4KK@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_267461_1	1249627.D779_2196	1.66e-36	135.0	28I2K@1|root,2Z86N@2|Bacteria,1R1GA@1224|Proteobacteria,1RRPU@1236|Gammaproteobacteria,1WXHU@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_267461_2	472759.Nhal_3943	1.91e-25	105.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1WW41@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_549064_1	1123399.AQVE01000022_gene337	3.52e-24	103.0	COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,1RP5U@1236|Gammaproteobacteria,46010@72273|Thiotrichales	72273|Thiotrichales	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_725476_1	1249627.D779_4215	1.55e-20	92.4	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1WWWW@135613|Chromatiales	135613|Chromatiales	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
k59_725476_2	1121035.AUCH01000006_gene646	2.04e-26	100.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,2VUC8@28216|Betaproteobacteria,2KX0I@206389|Rhodocyclales	206389|Rhodocyclales	P	protein involved in tolerance to divalent cations	cutA1	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
k59_1015728_1	1049564.TevJSym_al00260	5.9e-33	123.0	COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,1RNZU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	ribonuclease II	-	-	3.1.13.1	ko:K01147	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNB
k59_1781421_1	266264.Rmet_1288	7.78e-22	93.2	COG1773@1|root,COG1773@2|Bacteria,1N813@1224|Proteobacteria,2VUNU@28216|Betaproteobacteria	28216|Betaproteobacteria	C	[NiFe]-hydrogenase assembly, chaperone, HybE	hoxT	-	-	-	-	-	-	-	-	-	-	-	NiFe-hyd_HybE,Rubredoxin
k59_490493_1	1266914.ATUK01000013_gene1759	1.37e-49	161.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,1WWV2@135613|Chromatiales	135613|Chromatiales	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
k59_490493_2	1535422.ND16A_0141	3.4e-22	94.7	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,2Q5R3@267889|Colwelliaceae	1236|Gammaproteobacteria	M	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD	lpxD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	ic_1306.c0216	Hexapep,Hexapep_2,LpxD
k59_1085426_1	272623.L0375	1.13e-13	69.7	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,4HII1@91061|Bacilli,1YBQT@1357|Lactococcus	91061|Bacilli	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
k59_1085426_2	388413.ALPR1_11780	5.3e-13	67.0	COG0130@1|root,COG0130@2|Bacteria,4NESK@976|Bacteroidetes,47P98@768503|Cytophagia	976|Bacteroidetes	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
k59_1494127_1	1197906.CAJQ02000038_gene4710	1.76e-31	126.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,3JSY1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_607769_1	754476.Q7A_2930	3.99e-80	254.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,460CV@72273|Thiotrichales	72273|Thiotrichales	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_267505_1	270374.MELB17_15841	1.03e-71	228.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,1RNZZ@1236|Gammaproteobacteria,4644R@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	iECSF_1327.ECSF_2340	AIRS,AIRS_C
k59_267505_2	283699.D172_2993	1.47e-17	80.1	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,1RMHS@1236|Gammaproteobacteria,2Q0BM@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2500,iBWG_1329.BWG_2264,iECDH10B_1368.ECDH10B_2666,iECDH1ME8569_1439.ECDH1ME8569_2426,iEcDH1_1363.EcDH1_1169,iJO1366.b2500,iJR904.b2500,iY75_1357.Y75_RS13050	Formyl_trans_N
k59_1723045_1	2340.JV46_16790	1.81e-74	242.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1J5IS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_1665680_2	926560.KE387027_gene334	8.61e-61	193.0	COG0262@1|root,COG0262@2|Bacteria,1WMN7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	-	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
k59_1665680_3	243365.CV_1027	5.02e-24	97.1	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2VIIR@28216|Betaproteobacteria,2KPIK@206351|Neisseriales	206351|Neisseriales	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
k59_431689_1	367299.JOEE01000003_gene2796	2.9e-107	319.0	COG1946@1|root,COG1946@2|Bacteria,2GJ1B@201174|Actinobacteria,4FFTF@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acyl-CoA thioesterase	tesB	-	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT_3
k59_725505_1	394.NGR_a01350	7.56e-98	294.0	COG3547@1|root,COG3547@2|Bacteria,1QYJU@1224|Proteobacteria,2U1TU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1665686_1	471853.Bcav_2503	3.22e-43	158.0	COG0575@1|root,COG0575@2|Bacteria,2I7ZA@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
k59_1494148_1	744980.TRICHSKD4_0885	6.34e-51	177.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,2TUER@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
k59_1371721_1	103733.JNYO01000004_gene7599	2.32e-11	64.3	COG0247@1|root,COG0247@2|Bacteria,2GJ7M@201174|Actinobacteria,4DYWI@85010|Pseudonocardiales	201174|Actinobacteria	C	Fe-S oxidoreductase	fadF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_1605828_1	566466.NOR53_2606	9.14e-34	125.0	COG4313@1|root,COG4313@2|Bacteria,1MWCX@1224|Proteobacteria,1S4A1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG4313 Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
k59_1016465_1	264730.PSPPH_A0061	1.25e-139	401.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1Z7QZ@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_1323283_1	713586.KB900536_gene34	1.77e-164	491.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1WVV0@135613|Chromatiales	135613|Chromatiales	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_432540_1	76869.PputGB1_3049	1.17e-55	190.0	COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,1RQWI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_1371722_1	452637.Oter_1466	3.74e-34	130.0	COG0243@1|root,COG0243@2|Bacteria,46U1H@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1371722_2	1191523.MROS_1775	4.83e-98	288.0	COG0437@1|root,COG0437@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	nrfC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044464,GO:0055114,GO:0098809	-	ko:K04014,ko:K08353,ko:K08358,ko:K16293	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10149,R10150	RC02823,RC03109	ko00000,ko00001,ko02000	5.A.3.10,5.A.3.5	-	iUMNK88_1353.UMNK88_4933	Fer4,Fer4_11,Fer4_3,Fer4_4
k59_1371722_3	1191523.MROS_1776	3.11e-51	173.0	COG3301@1|root,COG3301@2|Bacteria	2|Bacteria	P	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD,NrfD_2
k59_843849_2	882378.RBRH_02095	1.59e-90	282.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,1K0F2@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_912069_1	1206726.BAFV01000052_gene3556	2.93e-11	67.0	COG0439@1|root,COG1984@1|root,COG2049@1|root,COG4770@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4G9PK@85025|Nocardiaceae	201174|Actinobacteria	EI	Allophanate hydrolase subunit 1	uca	-	6.3.4.6	ko:K01941	ko00220,ko00791,ko01100,map00220,map00791,map01100	-	R00774	RC00378	ko00000,ko00001,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D
k59_315532_1	1163617.SCD_n00015	4.75e-105	323.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_491371_1	999541.bgla_2g18740	3.1e-67	228.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,1K16F@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_1605832_1	323850.Shew_1021	1.64e-29	124.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,2Q9MS@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Peptidase M23B	yebA	-	-	-	-	-	-	-	-	-	-	-	OapA,OapA_N,Peptidase_M23
k59_971113_1	472759.Nhal_3693	2.13e-112	331.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1WXDH@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_35571_1	557599.MKAN_25710	1.02e-91	286.0	COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,234PM@1762|Mycobacteriaceae	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_383797_1	1249627.D779_1297	3.56e-136	400.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,1RSEQ@1236|Gammaproteobacteria,1WXQW@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR_N,TPP_enzyme_C
k59_1134833_1	641491.DND132_0810	8.95e-53	187.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1NR3M@1224|Proteobacteria,42N3G@68525|delta/epsilon subdivisions,2WIS9@28221|Deltaproteobacteria,2M89U@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
k59_843855_1	439235.Dalk_2466	8.4e-97	295.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,42NKV@68525|delta/epsilon subdivisions,2WKPA@28221|Deltaproteobacteria,2MIDW@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_843855_2	1150626.PHAMO_270085	1.14e-09	57.8	COG1028@1|root,COG1028@2|Bacteria,1MWGC@1224|Proteobacteria,2TSNX@28211|Alphaproteobacteria,2JRKC@204441|Rhodospirillales	204441|Rhodospirillales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_726373_1	323098.Nwi_0719	1.43e-35	140.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2TS8I@28211|Alphaproteobacteria,3JRH5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	nirB	-	1.2.1.58,1.7.1.15	ko:K00362,ko:K18359	ko00360,ko00910,ko01120,map00360,map00910,map01120	M00530	R00787,R02450	RC00004,RC00176,RC02860	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Rieske_2
k59_269158_1	298654.FraEuI1c_4487	1.31e-10	63.2	COG4585@1|root,COG4585@2|Bacteria,2GQQ8@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_269158_2	479432.Sros_3331	1.2e-71	224.0	COG2197@1|root,COG2197@2|Bacteria,2IFE7@201174|Actinobacteria,4ENBQ@85012|Streptosporangiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_315539_4	2340.JV46_19390	3.43e-10	61.2	COG2863@1|root,COG2863@2|Bacteria,1R5BS@1224|Proteobacteria,1RYHW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_CBB3
k59_1495340_1	395493.BegalDRAFT_2180	0.000304	42.4	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,46104@72273|Thiotrichales	72273|Thiotrichales	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_1495340_2	187272.Mlg_1900	0.0	885.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1WVW2@135613|Chromatiales	135613|Chromatiales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_912101_1	595460.RRSWK_02689	2.56e-19	88.2	COG0705@1|root,COG0705@2|Bacteria	2|Bacteria	S	proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
k59_1851589_1	314264.ROS217_09510	2.23e-60	191.0	COG2143@1|root,COG2143@2|Bacteria,1QDKY@1224|Proteobacteria,2U1M5@28211|Alphaproteobacteria,46PQ3@74030|Roseovarius	28211|Alphaproteobacteria	O	COG2143 Thioredoxin-related protein	soxW	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
k59_971146_1	693661.Arcve_1835	3.07e-68	215.0	arCOG10218@1|root,arCOG10218@2157|Archaea,2XXN4@28890|Euryarchaeota,2467G@183980|Archaeoglobi	183980|Archaeoglobi	C	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
k59_1260910_1	1056820.KB900656_gene3603	1.04e-101	301.0	COG0500@1|root,COG0500@2|Bacteria,1QVF3@1224|Proteobacteria,1T2D6@1236|Gammaproteobacteria,2PQ8Z@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
k59_667923_1	1049564.TevJSym_ax00200	2.16e-87	266.0	COG1085@1|root,COG1085@2|Bacteria,1MU3E@1224|Proteobacteria,1SJJV@1236|Gammaproteobacteria,1J77S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Galactose-1-phosphate uridyl transferase, N-terminal domain	galT	-	-	-	-	-	-	-	-	-	-	-	DUF4921,GalP_UDP_tr_C,GalP_UDP_transf
k59_667923_2	1049564.TevJSym_ax00210	1.41e-55	178.0	COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1JBWT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	ACT domain	gcvR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT,ACT_6
k59_1260913_1	472759.Nhal_0265	4.53e-55	189.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1WW2F@135613|Chromatiales	135613|Chromatiales	P	Chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
k59_383829_1	439235.Dalk_1210	5.15e-67	232.0	COG2208@1|root,COG5000@1|root,COG2208@2|Bacteria,COG5000@2|Bacteria,1RCHY@1224|Proteobacteria,42R1G@68525|delta/epsilon subdivisions,2WMR7@28221|Deltaproteobacteria,2MJNU@213118|Desulfobacterales	28221|Deltaproteobacteria	T	protein phosphatase 2C domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE
k59_1495361_2	446469.Sked_31840	4.16e-31	115.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_1723956_2	1123400.KB904768_gene3402	4.66e-49	167.0	COG1910@1|root,COG1910@2|Bacteria,1MVS4@1224|Proteobacteria,1RY8Q@1236|Gammaproteobacteria,463K2@72273|Thiotrichales	72273|Thiotrichales	P	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,PBP_like
k59_1323354_1	1075090.GOAMR_03_01900	1.57e-40	147.0	COG0362@1|root,COG0362@2|Bacteria,2GJ2J@201174|Actinobacteria,4GAHT@85026|Gordoniaceae	201174|Actinobacteria	G	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
k59_1332760_1	236097.ADG881_3286	1.21e-27	106.0	COG3637@1|root,COG3637@2|Bacteria,1RDPZ@1224|Proteobacteria,1S4GQ@1236|Gammaproteobacteria,1XP8B@135619|Oceanospirillales	135619|Oceanospirillales	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
k59_1332760_2	984262.SGRA_0222	5.35e-11	63.9	COG0526@1|root,COG0526@2|Bacteria,4NEX3@976|Bacteroidetes,1IT79@117747|Sphingobacteriia	976|Bacteroidetes	O	PFAM AhpC TSA family	ccmG	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DUF4369
k59_1436827_1	1224136.AMFN01000001_gene3828	6.54e-17	85.5	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RQHM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	malZ	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004558,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009311,GO:0009313,GO:0009987,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0051691,GO:0051692,GO:0071704,GO:0090599,GO:1901575	3.2.1.135,3.2.1.20	ko:K01187,ko:K21575	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH13,GH31	iECH74115_1262.ECH74115_0480,iEcSMS35_1347.EcSMS35_0434,iSFV_1184.SFV_0368,iYL1228.KPN_00344	Alpha-amylase,Alpha-amylase_N,Malt_amylase_C
k59_1500984_1	2340.JV46_05320	6.64e-98	301.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,1S0H0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	cbaA	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_99598_1	582744.Msip34_1912	7.36e-23	97.1	COG0438@1|root,COG0438@2|Bacteria,1MUTA@1224|Proteobacteria,2W02N@28216|Betaproteobacteria,2KNH5@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_99598_2	1348657.M622_11530	9.03e-57	189.0	COG3660@1|root,COG3660@2|Bacteria,1RC47@1224|Proteobacteria,2VRI5@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Mitochondrial fission ELM1	-	-	-	ko:K07276	-	-	-	-	ko00000	-	-	-	Mito_fiss_Elm1
k59_673097_1	1249627.D779_1883	2.04e-131	377.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,1RN0Z@1236|Gammaproteobacteria,1WW47@135613|Chromatiales	135613|Chromatiales	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_673097_2	1056512.D515_04592	1.29e-37	134.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1XSH9@135623|Vibrionales	135623|Vibrionales	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_1201746_2	1304865.JAGF01000001_gene1910	8.44e-53	172.0	2E27K@1|root,32XDT@2|Bacteria,2GRMM@201174|Actinobacteria,4F2QE@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1139338_1	1049564.TevJSym_ak00380	7.5e-16	76.6	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1J572@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Oligopeptidase A	prlC	GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006465,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0034645,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051604,GO:0070011,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901576	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_1139338_2	1249627.D779_1863	2.35e-79	255.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1WW1J@135613|Chromatiales	135613|Chromatiales	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	-	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_144816_1	1120941.AUBL01000010_gene421	5.52e-39	142.0	COG1180@1|root,COG1180@2|Bacteria,2HKP9@201174|Actinobacteria,4D5EF@85005|Actinomycetales	201174|Actinobacteria	O	Radical SAM superfamily	proB	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
k59_144816_3	1266909.AUAG01000013_gene708	8.42e-12	67.4	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,1RQPK@1236|Gammaproteobacteria,1WX63@135613|Chromatiales	135613|Chromatiales	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
k59_980596_1	1224136.AMFN01000005_gene1088	4.7e-31	115.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	yrdA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0009987,GO:0016043,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071840	-	-	-	-	-	-	-	-	-	-	Hexapep
k59_980596_2	743721.Psesu_2832	1.1e-07	53.5	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1X3RB@135614|Xanthomonadales	135614|Xanthomonadales	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
k59_613821_1	1116472.MGMO_86c00250	2.7e-77	240.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,1XE1X@135618|Methylococcales	135618|Methylococcales	EH	PFAM Aminotransferase, class IV	-	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
k59_785919_1	582899.Hden_3391	6.1e-66	215.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2TT63@28211|Alphaproteobacteria,3N68E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_1671739_1	935840.JAEQ01000002_gene3653	7.86e-14	70.1	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2TZPK@28211|Alphaproteobacteria,43HBX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF502)	MA20_12960	-	-	-	-	-	-	-	-	-	-	-	DUF502
k59_1671739_2	572477.Alvin_0720	1.7e-38	142.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1WXVV@135613|Chromatiales	135613|Chromatiales	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_393116_2	1169152.AXVD01000027_gene2749	1.73e-24	98.2	2B34Q@1|root,2ZK49@2|Bacteria,2I2K1@201174|Actinobacteria,4G9WH@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_921502_1	933262.AXAM01000033_gene1642	4.6e-74	241.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MI52@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
k59_555148_1	2340.JV46_11260	1.42e-60	189.0	COG0346@1|root,COG0346@2|Bacteria,1RIR2@1224|Proteobacteria,1S7P4@1236|Gammaproteobacteria,1J6FS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_99623_1	1120934.KB894421_gene2610	8e-34	127.0	COG0183@1|root,COG0183@2|Bacteria,2GJI8@201174|Actinobacteria,4DXSK@85010|Pseudonocardiales	201174|Actinobacteria	I	Belongs to the thiolase family	fadA2	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_980616_1	1265505.ATUG01000003_gene519	2.67e-21	100.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WKC0@28221|Deltaproteobacteria,2MN70@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
k59_1552656_1	56780.SYN_00568	9.2e-73	238.0	COG0784@1|root,COG2202@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k59_203401_1	1304865.JAGF01000001_gene781	2.46e-73	232.0	COG1902@1|root,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria	201174|Actinobacteria	C	NADH flavin oxidoreductase NADH oxidase	namA	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_1266601_1	471853.Bcav_3275	3.2e-85	264.0	COG1609@1|root,COG1609@2|Bacteria,2GK1X@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
k59_673117_1	1454004.AW11_01520	1.78e-67	226.0	COG2114@1|root,COG2114@2|Bacteria,1RBTC@1224|Proteobacteria	1224|Proteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,Guanylate_cyc,dCache_1
k59_980624_1	247639.MGP2080_08144	2.46e-84	268.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,1T2DW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EQ	COG0146 N-methylhydantoinase B acetone carboxylase, alpha subunit	hyuB	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_980625_1	1177154.Y5S_01430	3.8e-39	143.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1XHA4@135619|Oceanospirillales	135619|Oceanospirillales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_980625_2	1215114.BBIU01000013_gene1938	6.49e-36	124.0	COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,1S8VY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
k59_1376725_1	1049564.TevJSym_ag00510	2.65e-28	109.0	COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,1J4SR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host	djlA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0051087,GO:0071944	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
k59_1376725_2	1249627.D779_0752	9.84e-13	65.9	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,1WX9I@135613|Chromatiales	135613|Chromatiales	G	Belongs to the ribulose-phosphate 3-epimerase family	-	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_848974_3	357808.RoseRS_0014	6.8e-115	355.0	COG0366@1|root,COG0366@2|Bacteria,2G5NW@200795|Chloroflexi,376G5@32061|Chloroflexia	32061|Chloroflexia	G	SMART alpha amylase, catalytic sub domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
k59_921533_1	56780.SYN_00706	1.87e-85	261.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,42MRX@68525|delta/epsilon subdivisions,2WMIV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
k59_496556_1	582899.Hden_0280	9.48e-31	121.0	COG0810@1|root,COG0810@2|Bacteria,1NI45@1224|Proteobacteria,2VAPS@28211|Alphaproteobacteria,3N8I0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	TonB C terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_2,TonB_C
k59_496556_2	582899.Hden_0281	1.51e-50	165.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2UA46@28211|Alphaproteobacteria,3N8VA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Biopolymer transport protein	tolR	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
k59_613845_1	153948.NAL212_0013	2.37e-103	305.0	COG3676@1|root,COG3676@2|Bacteria,1QTF7@1224|Proteobacteria,2VSUV@28216|Betaproteobacteria	28216|Betaproteobacteria	L	ISXO2-like transposase domain	-	-	-	ko:K07488	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1595
k59_99659_1	1121479.AUBS01000009_gene1477	1.66e-69	222.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the thiolase family	MA20_05130	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_320766_1	706587.Desti_2540	6.19e-102	305.0	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,42MQY@68525|delta/epsilon subdivisions,2WJGJ@28221|Deltaproteobacteria,2MREB@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM thiamine pyrophosphate enzyme	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_731704_1	472759.Nhal_1621	3.13e-21	90.1	COG3381@1|root,COG3381@2|Bacteria,1PYCM@1224|Proteobacteria,1THFE@1236|Gammaproteobacteria,1X123@135613|Chromatiales	135613|Chromatiales	S	PFAM cytoplasmic chaperone TorD family protein	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
k59_731704_3	1121033.AUCF01000005_gene5260	1.47e-09	60.1	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2TTPX@28211|Alphaproteobacteria,2JPWY@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_393169_1	1089453.GOSPT_145_00010	4.83e-27	108.0	COG3344@1|root,COG3344@2|Bacteria,2GUJS@201174|Actinobacteria,4GD7Y@85026|Gordoniaceae	201174|Actinobacteria	L	Group II intron, maturase-specific domain	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_42679_1	1121405.dsmv_2561	3.33e-61	199.0	COG0834@1|root,COG0834@2|Bacteria,1MWDK@1224|Proteobacteria,42NVT@68525|delta/epsilon subdivisions,2WIRY@28221|Deltaproteobacteria,2MI8X@213118|Desulfobacterales	28221|Deltaproteobacteria	ET	SMART ABC-type transporter, periplasmic subunit family 3, ionotropic glutamate receptor	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_980667_1	76114.ebA872	1.99e-78	240.0	COG0225@1|root,COG0225@2|Bacteria,1R33Z@1224|Proteobacteria,2VRHA@28216|Betaproteobacteria,2KYN1@206389|Rhodocyclales	206389|Rhodocyclales	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_144862_1	187272.Mlg_1454	6.55e-11	62.4	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WW6D@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_144862_2	1384054.N790_01190	2.03e-28	112.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,1X446@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	GO:0002097,GO:0002098,GO:0002143,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_1861173_1	1265505.ATUG01000002_gene2543	6e-14	70.5	COG0338@1|root,COG0338@2|Bacteria,1Q4TK@1224|Proteobacteria,42ZVE@68525|delta/epsilon subdivisions,2WV9P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	D12 class N6 adenine-specific DNA methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1861173_2	697282.Mettu_4401	1.9e-55	182.0	COG0270@1|root,COG0270@2|Bacteria,1NUGP@1224|Proteobacteria	1224|Proteobacteria	L	C-5 cytosine-specific DNA methylase	-	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
k59_393190_1	1288494.EBAPG3_16830	6.15e-06	55.5	COG2770@1|root,COG4251@1|root,COG2770@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2VJGY@28216|Betaproteobacteria,372VE@32003|Nitrosomonadales	28216|Betaproteobacteria	T	GHKL domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HAMP,HATPase_c,HisKA,PAS,PAS_9,TarH
k59_496587_1	387093.SUN_0385	7.87e-103	305.0	COG0583@1|root,COG0583@2|Bacteria,1R8CE@1224|Proteobacteria,42PKW@68525|delta/epsilon subdivisions,2YNJK@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_393192_1	450851.PHZ_c2745	3.75e-34	135.0	COG1629@1|root,COG4774@1|root,COG1629@2|Bacteria,COG4774@2|Bacteria,1R479@1224|Proteobacteria,2TV3V@28211|Alphaproteobacteria,2KFVU@204458|Caulobacterales	204458|Caulobacterales	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_1501060_1	1033802.SSPSH_002856	7.63e-46	167.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	P-type atpase	ccoI	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_921596_1	1347342.BN863_10510	2.65e-46	165.0	COG3746@1|root,COG3746@2|Bacteria,4NK5I@976|Bacteroidetes	976|Bacteroidetes	P	phosphate-selective porin O and P	-	-	-	ko:K07221	-	-	-	-	ko00000,ko02000	1.B.5.1	-	-	Porin_O_P
k59_555209_1	864051.BurJ1DRAFT_1358	7.28e-16	82.4	COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,2VMZA@28216|Betaproteobacteria,1KN8I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	TIGRFAM pilus (MSHA type) biogenesis protein MshL	-	-	-	ko:K02453,ko:K12282	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	STN,Secretin,Secretin_N_2
k59_1092466_1	1121875.KB907546_gene2207	5.68e-58	193.0	COG5476@1|root,COG5476@2|Bacteria,4NG23@976|Bacteroidetes,1I0K5@117743|Flavobacteriia	2|Bacteria	S	MlrC C-terminus	-	-	-	ko:K19048	-	-	-	-	ko00000,ko02048	-	-	-	DUF1485,MlrC_C
k59_1092466_2	329726.AM1_6326	2.88e-35	130.0	COG3039@1|root,COG3039@2|Bacteria,1G7AF@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase IS4 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_5
k59_144885_1	1429046.RR21198_3063	1.47e-55	182.0	COG0726@1|root,COG0726@2|Bacteria,2HEQK@201174|Actinobacteria,4FWR1@85025|Nocardiaceae	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
k59_99718_2	313628.LNTAR_08329	4.95e-62	201.0	COG0205@1|root,COG0205@2|Bacteria	2|Bacteria	G	6-phosphofructokinase activity	pfp	-	2.7.1.90	ko:K00895	ko00010,ko00030,ko00051,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map01100,map01110,map01120,map01130	-	R00764,R02073	RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_437879_1	377629.TERTU_0938	1.52e-46	168.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,2PQ0Z@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	G	Carbohydrate phosphorylase	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_1552716_1	479431.Namu_1612	2.01e-80	244.0	2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria,4EVC6@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
k59_275882_1	1121405.dsmv_2465	5.6e-92	287.0	COG1123@1|root,COG4172@2|Bacteria	2|Bacteria	P	Belongs to the ABC transporter superfamily	cbiO	-	3.6.3.24	ko:K02031,ko:K02032,ko:K10824,ko:K15587,ko:K16786,ko:K16787	ko02010,ko02024,map02010,map02024	M00239,M00440,M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35,3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1139409_1	379731.PST_2051	1.1e-71	220.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,1Z0V2@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	G	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
k59_320806_1	935839.JAGJ01000003_gene1466	3.61e-138	413.0	COG3266@1|root,COG3266@2|Bacteria,2I2EC@201174|Actinobacteria,4F49Y@85017|Promicromonosporaceae	201174|Actinobacteria	S	Domain of Unknown Function (DUF349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF349
k59_393224_1	314278.NB231_13151	1.2e-52	177.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria,1WX3F@135613|Chromatiales	135613|Chromatiales	E	Belongs to the peptidase M20A family. ArgE subfamily	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_275884_1	63737.Npun_F5467	2.85e-76	261.0	COG2202@1|root,COG3852@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3852@2|Bacteria,COG5001@2|Bacteria,1G0BS@1117|Cyanobacteria,1HTQ5@1161|Nostocales	1117|Cyanobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_99733_1	1122963.AUHB01000003_gene3848	2.19e-24	102.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,36XQE@31993|Methylocystaceae	28211|Alphaproteobacteria	L	TRCF	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_99733_2	991905.SL003B_2233	1.05e-24	100.0	COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,2TRJ6@28211|Alphaproteobacteria,4BQGC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	DSBA-like thioredoxin domain	dsb	-	-	-	-	-	-	-	-	-	-	-	DSBA
k59_731755_1	1032480.MLP_53410	1.08e-08	54.7	COG2197@1|root,COG2197@2|Bacteria,2IFE7@201174|Actinobacteria	201174|Actinobacteria	KT	regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_731755_2	543632.JOJL01000004_gene4132	2.34e-41	153.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria,4DB80@85008|Micromonosporales	201174|Actinobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	degS	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_1376794_1	1232437.KL662061_gene4185	8.14e-94	285.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2
k59_42745_1	448385.sce3807	1.22e-23	102.0	COG1409@1|root,COG1409@2|Bacteria,1MXD6@1224|Proteobacteria,42WZF@68525|delta/epsilon subdivisions,2WTE8@28221|Deltaproteobacteria,2Z34X@29|Myxococcales	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_1786669_1	1267005.KB911259_gene3860	7.82e-43	149.0	COG1409@1|root,COG1409@2|Bacteria,1MXD6@1224|Proteobacteria,2TSJ4@28211|Alphaproteobacteria,3N704@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_99745_1	1280950.HJO_00770	1.09e-18	90.1	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43XNB@69657|Hyphomonadaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2,TPR_16,TPR_8,Trans_reg_C
k59_673202_1	485916.Dtox_3501	7.14e-28	115.0	COG0303@1|root,COG0303@2|Bacteria,1TQJ8@1239|Firmicutes,248WP@186801|Clostridia,2613I@186807|Peptococcaceae	186801|Clostridia	H	MoeA N-terminal region (domain I and II)	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_786561_1	62928.azo0374	6.35e-95	285.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VH51@28216|Betaproteobacteria,2KU9W@206389|Rhodocyclales	206389|Rhodocyclales	O	Peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
k59_1139961_2	768671.ThimaDRAFT_3757	3.11e-44	158.0	COG0421@1|root,COG0421@2|Bacteria,1QZ2Z@1224|Proteobacteria	1224|Proteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_438558_1	1144319.PMI16_00922	1.64e-37	131.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,2VK49@28216|Betaproteobacteria,474CR@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	NADPH-dependent FMN reductase	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red,Flavodoxin_5
k59_438558_2	945543.VIBR0546_03730	3.08e-22	97.1	COG0069@1|root,COG3369@1|root,COG0069@2|Bacteria,COG3369@2|Bacteria,1MU7B@1224|Proteobacteria,1RP1C@1236|Gammaproteobacteria,1XSHA@135623|Vibrionales	135623|Vibrionales	E	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase,zf-CDGSH
k59_1501939_1	990285.RGCCGE502_16365	4.56e-81	252.0	COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2TSX2@28211|Alphaproteobacteria,4BA0J@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
k59_1443993_1	1167006.UWK_00605	1.13e-83	262.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,42MTV@68525|delta/epsilon subdivisions,2WKVP@28221|Deltaproteobacteria,2MMZI@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF853)	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
k59_1560000_1	1517681.HW45_09715	4.85e-58	194.0	COG0786@1|root,COG0786@2|Bacteria,1MVBC@1224|Proteobacteria,1RP0S@1236|Gammaproteobacteria,1XUE5@135623|Vibrionales	135623|Vibrionales	P	Catalyzes the sodium-dependent transport of glutamate	gltS	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
k59_1792888_1	469382.Hbor_22500	1.06e-11	65.1	COG1863@1|root,arCOG03099@2157|Archaea,2XXB1@28890|Euryarchaeota,23VUY@183963|Halobacteria	183963|Halobacteria	P	Multisubunit na h antiporter, mnhe subunit	-	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
k59_1792888_2	1121937.AUHJ01000004_gene965	3.6e-28	104.0	COG2212@1|root,COG2212@2|Bacteria,1N6VV@1224|Proteobacteria,1SE40@1236|Gammaproteobacteria,468Q3@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Multiple resistance and pH regulation protein F (MrpF / PhaF)	mnhF	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
k59_1792888_3	1198232.CYCME_1786	5.93e-12	62.0	COG1320@1|root,COG1320@2|Bacteria,1PC9X@1224|Proteobacteria,1SX6D@1236|Gammaproteobacteria,4630V@72273|Thiotrichales	72273|Thiotrichales	P	Na+/H+ antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_992209_1	572477.Alvin_0727	1.87e-42	150.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,1WW19@135613|Chromatiales	135613|Chromatiales	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_1560001_2	1317118.ATO8_04586	1.09e-55	183.0	COG3103@1|root,COG4991@2|Bacteria,1Q9K3@1224|Proteobacteria,2V9BJ@28211|Alphaproteobacteria,4KP3Y@93682|Roseivivax	2|Bacteria	T	sh3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
k59_739178_1	765911.Thivi_0415	4.14e-21	91.3	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1WVUR@135613|Chromatiales	135613|Chromatiales	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
k59_739178_2	1198232.CYCME_0911	1.31e-17	75.9	COG3242@1|root,COG3242@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2065)	yjeT	-	-	ko:K09937	-	-	-	-	ko00000	-	-	-	DUF2065
k59_739178_3	987059.RBXJA2T_17956	1.19e-14	74.3	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2VI9W@28216|Betaproteobacteria,1KJ28@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_152328_1	448385.sce7333	2.17e-101	313.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2YUFN@29|Myxococcales	28221|Deltaproteobacteria	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB	hscA	-	-	ko:K04044	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
k59_111106_1	56780.SYN_03033	5.12e-08	52.8	2A1M5@1|root,30PV9@2|Bacteria,1N5W2@1224|Proteobacteria,42RI6@68525|delta/epsilon subdivisions,2WNKT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_111106_2	748727.CLJU_c19220	6.1e-15	78.2	COG1457@1|root,COG1457@2|Bacteria,1TTBN@1239|Firmicutes,248EP@186801|Clostridia,36FDK@31979|Clostridiaceae	186801|Clostridia	F	Permease for cytosine/purines, uracil, thiamine, allantoin	cytX	-	-	-	-	-	-	-	-	-	-	-	Transp_cyt_pur
k59_992215_1	388051.AUFE01000012_gene2927	1.62e-55	176.0	COG0346@1|root,COG0346@2|Bacteria,1RHD4@1224|Proteobacteria,2VSJM@28216|Betaproteobacteria,1K7MX@119060|Burkholderiaceae	28216|Betaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
k59_52765_1	1121935.AQXX01000142_gene2322	7.18e-29	105.0	2E588@1|root,3300P@2|Bacteria,1N79I@1224|Proteobacteria,1SCYA@1236|Gammaproteobacteria,1XM1Y@135619|Oceanospirillales	135619|Oceanospirillales	S	Domain of unknown function (DUF5062)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5062
k59_52765_2	857087.Metme_0076	3.77e-57	181.0	COG3791@1|root,COG3791@2|Bacteria,1N0W7@1224|Proteobacteria,1SC8R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_52765_3	1500894.JQNN01000001_gene4315	1.36e-05	45.1	COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,2VRAZ@28216|Betaproteobacteria,47481@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Belongs to the UPF0178 family	yaiI	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
k59_1026798_1	1123368.AUIS01000015_gene2639	4.33e-66	225.0	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,1RNP1@1236|Gammaproteobacteria,2NCSD@225057|Acidithiobacillales	225057|Acidithiobacillales	MV	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1444006_1	367299.JOEE01000001_gene1690	1.74e-67	215.0	COG0624@1|root,COG0624@2|Bacteria,2GJDE@201174|Actinobacteria,4FEEY@85021|Intrasporangiaceae	201174|Actinobacteria	E	Allantoate amidohydrolase	amaB	-	3.5.1.6,3.5.1.87,3.5.3.9	ko:K02083,ko:K06016	ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120	M00046	R00905,R02423,R04666	RC00064,RC00096	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_933028_1	28072.Nos7524_1349	9.81e-17	87.8	COG2374@1|root,COG2706@1|root,COG2931@1|root,COG3210@1|root,COG3291@1|root,COG2374@2|Bacteria,COG2706@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,1GJ9G@1117|Cyanobacteria,1HR22@1161|Nostocales	1117|Cyanobacteria	QU	PFAM 3-carboxy-cis,cis-muconate lactonizing enzyme	-	-	3.4.21.10	ko:K01317	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	DUF4347,Lactonase
k59_856063_1	1353531.AZNX01000006_gene5481	2.63e-67	213.0	COG4089@1|root,COG4089@2|Bacteria,1MV8K@1224|Proteobacteria,2U3GA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1614)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1614
k59_152344_2	323848.Nmul_A0797	2.09e-30	117.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,372J0@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
k59_680598_1	1267005.KB911257_gene859	4.38e-96	292.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2TQT3@28211|Alphaproteobacteria,3N62E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_111141_1	666685.R2APBS1_1285	1.89e-57	190.0	COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,1RNI1@1236|Gammaproteobacteria,1X32Q@135614|Xanthomonadales	135614|Xanthomonadales	S	Specifically methylates the adenine in position 2030 of 23S rRNA	rlmJ	-	2.1.1.266	ko:K07115	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RsmJ
k59_52797_1	1123519.PSJM300_14670	5.5e-06	49.7	COG4701@1|root,COG4701@2|Bacteria,1NHRC@1224|Proteobacteria,1SDJY@1236|Gammaproteobacteria,1Z21M@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
k59_52797_2	477228.YO5_03837	8.96e-16	75.5	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1Z01N@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iECS88_1305.ECS88_0100	LpxC
k59_404652_1	396588.Tgr7_2622	2.2e-58	198.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales	135613|Chromatiales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_404652_2	999541.bgla_1g31270	6.23e-30	117.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2VIMV@28216|Betaproteobacteria,1K0I7@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_1384251_1	1267005.KB911258_gene622	1.31e-94	281.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2TT7W@28211|Alphaproteobacteria,3N675@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_1872696_1	679937.Bcop_2057	4.11e-07	53.9	COG3712@1|root,COG3712@2|Bacteria,4NHHS@976|Bacteroidetes,2FPTU@200643|Bacteroidia,4AP5I@815|Bacteroidaceae	976|Bacteroidetes	PT	COG3712 Fe2 -dicitrate sensor, membrane component	-	-	-	-	-	-	-	-	-	-	-	-	DUF4974,FecR
k59_856077_1	1095767.CAHD01000174_gene2576	3.27e-100	303.0	COG1294@1|root,COG1294@2|Bacteria,2GMFV@201174|Actinobacteria,4F0JN@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM cytochrome bd ubiquinol oxidase subunit II	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
k59_1444032_1	1453501.JELR01000002_gene342	7.22e-60	211.0	COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,1SEWA@1236|Gammaproteobacteria,469S7@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
k59_1872714_1	1121087.AUCK01000027_gene213	1.97e-35	138.0	COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,4H9UP@91061|Bacilli,1ZBAT@1386|Bacillus	91061|Bacilli	L	Single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1,ssDNA-exonuc_C
k59_52820_1	388399.SSE37_01500	2.43e-41	150.0	COG3550@1|root,COG3550@2|Bacteria,1N458@1224|Proteobacteria,2TVQF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM HipA domain protein	-	-	2.7.11.1	ko:K07154	-	-	-	-	ko00000,ko01000,ko01001,ko02048	-	-	-	Couple_hipA,HipA_C
k59_1618282_1	765912.Thimo_0677	2.33e-148	441.0	COG1205@1|root,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,1S0XD@1236|Gammaproteobacteria,1WXNC@135613|Chromatiales	135613|Chromatiales	L	DEAD DEAH box	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
k59_739232_1	1454004.AW11_03509	5.21e-32	125.0	COG1752@1|root,COG1752@2|Bacteria,1R7RX@1224|Proteobacteria,2VMTI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_739232_2	948106.AWZT01000022_gene3688	9.43e-13	67.4	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,1JZTX@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_992283_1	153948.NAL212_1999	1.05e-15	76.6	COG2433@1|root,COG2433@2|Bacteria,1QWB7@1224|Proteobacteria,2WBIH@28216|Betaproteobacteria,37377@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Bacterial SH3 domain homologues	-	-	-	ko:K07184	-	-	-	-	ko00000	-	-	-	SH3_3
k59_992285_1	1417296.U879_20710	4.2e-82	256.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,2U0SB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K21834	-	-	-	-	ko00000	-	-	-	CCG,DUF3483,ETF,Fer4_10,Fer4_8
k59_1344540_1	1123354.AUDR01000013_gene704	2.2e-89	271.0	2C7Q9@1|root,2Z96K@2|Bacteria,1MWKA@1224|Proteobacteria,2VN2M@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1209496_1	626418.bglu_2g01170	0.000444	45.1	COG1846@1|root,COG1846@2|Bacteria,1RFUJ@1224|Proteobacteria,2VSHK@28216|Betaproteobacteria,1K7IP@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Regulatory protein MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
k59_1560775_2	998674.ATTE01000001_gene2702	3.52e-30	115.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,462D8@72273|Thiotrichales	72273|Thiotrichales	KT	LytTr DNA-binding domain	-	-	-	ko:K08083	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
k59_563036_1	631362.Thi970DRAFT_00977	1.04e-19	87.4	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales	135613|Chromatiales	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
k59_563036_2	518766.Rmar_1465	1.59e-08	57.8	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
k59_286756_1	367299.JOEE01000004_gene1441	2.32e-103	303.0	COG1845@1|root,COG1845@2|Bacteria,2GKK8@201174|Actinobacteria,4FE59@85021|Intrasporangiaceae	201174|Actinobacteria	C	Cytochrome	ctaE	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
k59_934053_1	1121105.ATXL01000015_gene1802	1.9e-28	121.0	COG0714@1|root,COG1401@1|root,COG0714@2|Bacteria,COG1401@2|Bacteria,1TPIP@1239|Firmicutes,4HBRV@91061|Bacilli,4B45Q@81852|Enterococcaceae	91061|Bacilli	V	AAA domain (dynein-related subfamily)	-	-	-	ko:K07452	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	AAA_5
k59_1737133_1	768671.ThimaDRAFT_4071	2.9e-99	301.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,1WW1T@135613|Chromatiales	135613|Chromatiales	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	-	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_405788_1	748247.AZKH_0540	2.41e-37	130.0	COG5588@1|root,COG5588@2|Bacteria,1MWK3@1224|Proteobacteria,2VMAI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1326
k59_1027885_1	439497.RR11_122	2.74e-67	226.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,4ND0T@97050|Ruegeria	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	iorB	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_286792_1	357808.RoseRS_2504	1.23e-65	215.0	COG0477@1|root,COG2211@1|root,COG0477@2|Bacteria,COG2211@2|Bacteria,2G5J9@200795|Chloroflexi,377YG@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_504515_1	272560.BPSL3167	6.43e-122	359.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,1K15K@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Belongs to the dGTPase family. Type 2 subfamily	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_504515_2	477228.YO5_18292	4.07e-14	73.2	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1YZNV@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	GO:0000166,GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b3389,iBWG_1329.BWG_3080,iECDH10B_1368.ECDH10B_3564,iECDH1ME8569_1439.ECDH1ME8569_3268,iECNA114_1301.ECNA114_3486,iEcDH1_1363.EcDH1_0324,iJO1366.b3389,iJR904.b3389,iY75_1357.Y75_RS20275	DHQ_synthase
k59_934078_1	96561.Dole_0075	9.54e-80	256.0	COG4770@1|root,COG5016@1|root,COG4770@2|Bacteria,COG5016@2|Bacteria,1P6RE@1224|Proteobacteria,43BQE@68525|delta/epsilon subdivisions,2X71H@28221|Deltaproteobacteria,2MHKV@213118|Desulfobacterales	28221|Deltaproteobacteria	CI	Conserved carboxylase domain	-	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_1560804_1	1121403.AUCV01000038_gene4228	1.84e-40	144.0	COG0711@1|root,COG0711@2|Bacteria,1R6C0@1224|Proteobacteria	1224|Proteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF_2	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,OSCP
k59_1027902_1	1123065.ATWL01000001_gene164	2.64e-31	124.0	28PUQ@1|root,2ZCFK@2|Bacteria,2GNQM@201174|Actinobacteria	201174|Actinobacteria	S	DNA-binding protein	-	GO:0008150,GO:0040007	-	-	-	-	-	-	-	-	-	-	DUF3071
k59_1619018_1	1380394.JADL01000011_gene3942	1.12e-113	339.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TU6U@28211|Alphaproteobacteria,2JPVH@204441|Rhodospirillales	204441|Rhodospirillales	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_405828_1	1322246.BN4_10791	3.28e-36	139.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,42PJQ@68525|delta/epsilon subdivisions,2WKR4@28221|Deltaproteobacteria,2M7SH@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	iAF987.Gmet_3470	CBS,Voltage_CLC
k59_934091_2	876269.ARWA01000001_gene1427	4.7e-19	85.9	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2TRMH@28211|Alphaproteobacteria,3N9YE@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Histidine-specific methyltransferase, SAM-dependent	MA20_09135	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
k59_621710_1	1026882.MAMP_02611	1.26e-80	252.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,45ZNF@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
k59_1793611_1	2340.JV46_15840	4.47e-92	282.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,1J5FI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Peptidoglycan polymerase that is essential for cell division	ftsW	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_792460_1	384765.SIAM614_19134	6.09e-54	176.0	COG4461@1|root,COG4461@2|Bacteria,1R6Q3@1224|Proteobacteria,2U74M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Membrane-bound lysozyme-inhibitor of c-type lysozyme	-	-	-	-	-	-	-	-	-	-	-	-	LprI,MliC
k59_1509992_1	335543.Sfum_1455	1.25e-28	117.0	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,42MW1@68525|delta/epsilon subdivisions,2WJBE@28221|Deltaproteobacteria,2MQZ4@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PFAM Patatin	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_1027917_2	292.DM42_6263	4.91e-39	136.0	COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,2VHG8@28216|Betaproteobacteria,1K027@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	fumarylacetoacetate (FAA) hydrolase	-	-	3.7.1.20	ko:K16165	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R01085	RC00326,RC00446	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
k59_1793616_1	1279038.KB907340_gene1478	1.03e-61	203.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TRX9@28211|Alphaproteobacteria,2JQ1W@204441|Rhodospirillales	204441|Rhodospirillales	E	FAD dependent oxidoreductase	ordL	-	-	ko:K09471	ko00330,ko01100,map00330,map01100	M00136	R07415	RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	DAO
k59_1737172_1	1469245.JFBG01000012_gene931	6.11e-101	298.0	COG0607@1|root,COG0607@2|Bacteria,1REGB@1224|Proteobacteria,1S580@1236|Gammaproteobacteria,1X2R1@135613|Chromatiales	135613|Chromatiales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_681425_1	519989.ECTPHS_00390	3.42e-90	284.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1WWKZ@135613|Chromatiales	135613|Chromatiales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_1873941_1	316407.85676040	1.43e-13	69.7	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,3XMC4@561|Escherichia	1236|Gammaproteobacteria	D	UTP diphosphatase activity	yhdE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_1873941_2	506534.Rhein_3540	4.72e-65	202.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria,1WY5P@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
k59_1101167_1	690850.Desaf_3058	8.38e-71	220.0	COG0577@1|root,COG0577@2|Bacteria,1RC4T@1224|Proteobacteria,42QZ6@68525|delta/epsilon subdivisions,2WMU4@28221|Deltaproteobacteria,2MB5S@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
k59_53971_2	1120944.JONS01000022_gene2352	6.58e-55	177.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4D411@85005|Actinomycetales	201174|Actinobacteria	KT	response regulator	tcrX	GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0098771	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1146403_2	525246.HMPREF0058_0478	1.97e-36	135.0	COG1559@1|root,COG1559@2|Bacteria,2GKGQ@201174|Actinobacteria,4D32F@85005|Actinomycetales	201174|Actinobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_328873_1	933262.AXAM01000078_gene1614	2.99e-59	185.0	COG1403@1|root,COG1403@2|Bacteria,1RGZQ@1224|Proteobacteria,42REM@68525|delta/epsilon subdivisions,2WNMG@28221|Deltaproteobacteria,2MJT7@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH
k59_1444777_1	446469.Sked_22270	8.07e-137	397.0	COG0137@1|root,COG0137@2|Bacteria,2GK96@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the argininosuccinate synthase family. Type	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0071944,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iNJ661.Rv1658	Arginosuc_synth
k59_1444777_2	935839.JAGJ01000007_gene3258	2.74e-14	72.4	COG0165@1|root,COG0165@2|Bacteria,2GJ2A@201174|Actinobacteria,4F45X@85017|Promicromonosporaceae	201174|Actinobacteria	E	Argininosuccinate lyase C-terminal	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_405862_1	1121035.AUCH01000013_gene3067	6.07e-93	290.0	COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,2VHGV@28216|Betaproteobacteria,2KUV2@206389|Rhodocyclales	206389|Rhodocyclales	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB	hscA	-	-	ko:K04044	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
k59_1101179_1	95619.PM1_0225625	8.04e-15	75.9	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Lipoprotein releasing system transmembrane protein	lolE	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_1101179_2	1122604.JONR01000016_gene4470	2.59e-12	65.1	2ENKU@1|root,33G87@2|Bacteria,1NMH6@1224|Proteobacteria,1SGDI@1236|Gammaproteobacteria,1X7KN@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1560841_1	95619.PM1_0206485	7.31e-56	188.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,1RRXR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ATPase, AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
k59_1802506_1	1121405.dsmv_3405	1.62e-86	268.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria,2MIR1@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1039824_1	396588.Tgr7_1508	1.33e-80	250.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria,1WWDK@135613|Chromatiales	135613|Chromatiales	C	Belongs to the citrate synthase family	-	-	2.3.3.5	ko:K01659	ko00640,map00640	-	R00931	RC00004,RC00406,RC02827	ko00000,ko00001,ko01000	-	-	-	Citrate_synt
k59_1629366_2	644282.Deba_3009	5.65e-14	75.1	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,42NCG@68525|delta/epsilon subdivisions,2WK7N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	-	-	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
k59_1113362_1	1255043.TVNIR_1173	5.86e-52	178.0	COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,1RPTU@1236|Gammaproteobacteria,1WXF3@135613|Chromatiales	135613|Chromatiales	I	Membrane protein involved in aromatic hydrocarbon degradation	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_750488_1	926564.KI911565_gene5918	8.04e-37	147.0	COG0739@1|root,COG0739@2|Bacteria,2I3XJ@201174|Actinobacteria,4F4XJ@85017|Promicromonosporaceae	201174|Actinobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_750488_2	67315.JOBD01000053_gene4481	3.8e-86	264.0	COG0561@1|root,COG0561@2|Bacteria	2|Bacteria	Q	phosphatase activity	supH	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
k59_800339_1	1122139.KB907864_gene2011	3.92e-25	105.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,1XJ89@135619|Oceanospirillales	135619|Oceanospirillales	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
k59_1802516_1	572477.Alvin_0527	1.02e-09	58.2	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,1S64Q@1236|Gammaproteobacteria,1WWVF@135613|Chromatiales	135613|Chromatiales	S	Competence protein	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
k59_455815_1	1229276.DI53_3047	1.88e-15	82.0	COG0673@1|root,COG0673@2|Bacteria,4NF9M@976|Bacteroidetes,1IPWB@117747|Sphingobacteriia	976|Bacteroidetes	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,TAT_signal
k59_632141_1	1049564.TevJSym_ab00650	9.86e-191	555.0	COG2304@1|root,COG2304@2|Bacteria,1MXU0@1224|Proteobacteria,1RZHF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	serine threonine protein kinase	ppkA	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	VWA,VWA_2
k59_1288123_1	1380347.JNII01000010_gene2393	8.58e-05	43.5	COG0200@1|root,COG0200@2|Bacteria,2II6M@201174|Actinobacteria,4ESSV@85013|Frankiales	201174|Actinobacteria	J	Binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
k59_1288123_2	1095772.CAHH01000006_gene2240	5.38e-26	96.7	COG1841@1|root,COG1841@2|Bacteria,2GQV0@201174|Actinobacteria	201174|Actinobacteria	J	Ribosomal protein L30	rpmD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
k59_1288123_3	935839.JAGJ01000006_gene3323	2.02e-103	305.0	COG0098@1|root,COG0098@2|Bacteria,2GJW8@201174|Actinobacteria,4F3RI@85017|Promicromonosporaceae	201174|Actinobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_750502_1	338963.Pcar_3094	1.1e-75	239.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42P19@68525|delta/epsilon subdivisions,2WK00@28221|Deltaproteobacteria,43UEG@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K19595	-	M00768,M00769	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2.25,2.A.6.2.34,8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
k59_1395167_2	1429046.RR21198_0466	8.44e-34	120.0	COG1950@1|root,COG1950@2|Bacteria,2IHP5@201174|Actinobacteria,4G28G@85025|Nocardiaceae	201174|Actinobacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
k59_1455512_1	1175306.GWL_21290	9.87e-64	206.0	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,2VH00@28216|Betaproteobacteria,472BN@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_1155570_1	1249627.D779_1779	6.08e-42	152.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1WVZJ@135613|Chromatiales	135613|Chromatiales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_867795_1	1335757.SPICUR_04870	5.77e-75	229.0	COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,1RPT7@1236|Gammaproteobacteria,1WY8B@135613|Chromatiales	135613|Chromatiales	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_163554_1	1126627.BAWE01000005_gene6111	6.47e-39	148.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_1039883_2	572477.Alvin_1043	5.51e-38	150.0	COG1368@1|root,COG1368@2|Bacteria,1RG6W@1224|Proteobacteria,1RY34@1236|Gammaproteobacteria,1WVXN@135613|Chromatiales	135613|Chromatiales	M	PFAM Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_573121_1	1288826.MSNKSG1_04401	6.15e-18	83.2	COG4902@1|root,COG4902@2|Bacteria,1RHUF@1224|Proteobacteria,1SAI2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized protein domain (DUF2202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2202
k59_1629445_1	743718.Isova_1665	9.15e-38	141.0	COG0441@1|root,COG0441@2|Bacteria,2GKTC@201174|Actinobacteria,4F38Z@85017|Promicromonosporaceae	201174|Actinobacteria	J	Threonyl and Alanyl tRNA synthetase second additional domain	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
k59_339746_1	3067.XP_002953537.1	8e-48	171.0	COG0626@1|root,KOG0053@2759|Eukaryota,37K09@33090|Viridiplantae,34GXJ@3041|Chlorophyta	3041|Chlorophyta	E	Cys/Met metabolism PLP-dependent enzyme	CGS1	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1395226_1	1123399.AQVE01000006_gene3586	1.89e-24	95.1	COG2924@1|root,COG2924@2|Bacteria,1MZ2V@1224|Proteobacteria,1S964@1236|Gammaproteobacteria,4616M@72273|Thiotrichales	72273|Thiotrichales	CO	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Iron_traffic
k59_1395226_2	321846.PS417_25665	1.95e-08	53.5	COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,1S5XY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane	-	-	-	ko:K08973	-	-	-	-	ko00000	-	-	-	UPF0093
k59_1395229_1	519989.ECTPHS_01919	3.64e-31	122.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,1WWMP@135613|Chromatiales	135613|Chromatiales	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1288227_2	526225.Gobs_1330	5.81e-78	246.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4EVS8@85013|Frankiales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
k59_867858_1	864051.BurJ1DRAFT_1593	1.37e-08	60.8	COG0457@1|root,COG0457@2|Bacteria,1Q7UR@1224|Proteobacteria,2VKBS@28216|Betaproteobacteria,1KJ62@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
k59_867860_1	933262.AXAM01000017_gene3127	4.08e-37	134.0	COG0546@1|root,COG0546@2|Bacteria,1MY9Y@1224|Proteobacteria,42SSC@68525|delta/epsilon subdivisions,2WN7Q@28221|Deltaproteobacteria,2MKDC@213118|Desulfobacterales	28221|Deltaproteobacteria	S	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_1113503_1	765911.Thivi_2629	1.95e-103	315.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,1RNQI@1236|Gammaproteobacteria,1WW64@135613|Chromatiales	135613|Chromatiales	M	Belongs to the mannose-6-phosphate isomerase type 2 family	-	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_1571360_1	159087.Daro_0979	3.08e-83	264.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VHW2@28216|Betaproteobacteria,2KUYG@206389|Rhodocyclales	206389|Rhodocyclales	C	Respiratory-chain NADH dehydrogenase	hoxF	-	1.12.1.2	ko:K18005	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_1522348_1	1193181.BN10_590053	1.45e-92	283.0	COG0341@1|root,COG0341@2|Bacteria,2GJRS@201174|Actinobacteria,4FENY@85021|Intrasporangiaceae	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_800407_1	767434.Fraau_0433	4.34e-15	74.7	COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,1RPH5@1236|Gammaproteobacteria,1X5GD@135614|Xanthomonadales	135614|Xanthomonadales	CH	COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases	-	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
k59_800407_2	1415778.JQMM01000001_gene127	4.76e-38	143.0	COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria,1J5RD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	enzyme of heme biosynthesis	hemY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02498	-	-	-	-	ko00000	-	-	-	HemY_N,TPR_2
k59_1690525_1	1210045.ALNP01000023_gene2896	1.31e-20	97.1	COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria	201174|Actinobacteria	D	Required for chromosome condensation and partitioning	smc	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_632226_1	234267.Acid_4877	9.25e-42	154.0	COG3064@1|root,COG3064@2|Bacteria,3Y7SB@57723|Acidobacteria	57723|Acidobacteria	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
k59_1039986_1	187272.Mlg_1344	4.55e-102	314.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1WW67@135613|Chromatiales	135613|Chromatiales	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_867888_1	1110502.TMO_3120	4.67e-63	208.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2TRMY@28211|Alphaproteobacteria,2JPE6@204441|Rhodospirillales	204441|Rhodospirillales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_1522370_1	994573.T472_0215740	1.61e-05	52.4	COG0671@1|root,COG0671@2|Bacteria,1V2ZH@1239|Firmicutes,24HRY@186801|Clostridia,36JBF@31979|Clostridiaceae	186801|Clostridia	I	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
k59_221809_1	590998.Celf_3450	1.26e-28	112.0	COG1316@1|root,COG1316@2|Bacteria,2I7ZM@201174|Actinobacteria,4F347@85016|Cellulomonadaceae	201174|Actinobacteria	K	LytR cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C
k59_221809_2	1304865.JAGF01000001_gene1511	1.93e-40	144.0	COG2233@1|root,COG2233@2|Bacteria,2GMH6@201174|Actinobacteria,4F0S4@85016|Cellulomonadaceae	201174|Actinobacteria	F	PFAM Xanthine uracil vitamin C permease	rutG	-	-	ko:K02824,ko:K03458	-	-	-	-	ko00000,ko02000	2.A.40,2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
k59_1220297_1	926569.ANT_08740	5.1e-17	77.4	COG2197@1|root,COG2197@2|Bacteria,2G6C5@200795|Chloroflexi	200795|Chloroflexi	K	COGs COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	ko:K11618	ko02020,map02020	M00481,M00754	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_1220297_2	1121413.JMKT01000010_gene788	4.45e-20	88.6	COG0500@1|root,COG2226@2|Bacteria,1RDQI@1224|Proteobacteria,42SIB@68525|delta/epsilon subdivisions,2WPCP@28221|Deltaproteobacteria,2ME8A@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
k59_573189_1	555778.Hneap_0971	7.63e-77	252.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_1220300_1	446466.Cfla_1687	3.07e-89	267.0	COG0623@1|root,COG0623@2|Bacteria,2GJ65@201174|Actinobacteria,4F0ZV@85016|Cellulomonadaceae	201174|Actinobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	inhA	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005504,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030312,GO:0030497,GO:0031406,GO:0032787,GO:0033293,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208,ko:K11611	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1455630_1	1089552.KI911559_gene939	2.61e-29	115.0	COG0385@1|root,COG0385@2|Bacteria,1MVXH@1224|Proteobacteria,2TTE0@28211|Alphaproteobacteria,2JSCP@204441|Rhodospirillales	204441|Rhodospirillales	S	Sodium Bile acid symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SBF
k59_163655_1	690597.JH730937_gene3409	1.29e-67	217.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1YNT6@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1629537_2	765911.Thivi_3691	1.07e-66	220.0	COG0642@1|root,COG1225@1|root,COG1225@2|Bacteria,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,1RPP2@1236|Gammaproteobacteria,1WXM4@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_573208_1	543728.Vapar_5778	1.98e-17	80.1	COG0500@1|root,COG2226@2|Bacteria,1PG85@1224|Proteobacteria,2WC4M@28216|Betaproteobacteria,4AIUN@80864|Comamonadaceae	28216|Betaproteobacteria	H	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_1155669_1	1500894.JQNN01000001_gene2305	8.96e-69	218.0	COG1215@1|root,COG1215@2|Bacteria,1QTWU@1224|Proteobacteria,2WGGD@28216|Betaproteobacteria,473WJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Glycosyl transferase family 2	arnC	-	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
k59_163687_1	1211114.ALIP01000033_gene1335	3.43e-86	278.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1X57I@135614|Xanthomonadales	135614|Xanthomonadales	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_48,DUF3372
k59_339838_1	1123054.KB907713_gene530	1.31e-30	125.0	COG2755@1|root,COG2755@2|Bacteria,1R43M@1224|Proteobacteria,1RRTK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
k59_1571433_1	484770.UFO1_1182	7.08e-82	250.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,4H387@909932|Negativicutes	909932|Negativicutes	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1288360_1	1382356.JQMP01000004_gene284	7.63e-10	59.7	COG0419@1|root,COG0419@2|Bacteria,2G682@200795|Chloroflexi,27XPG@189775|Thermomicrobia	189775|Thermomicrobia	L	Rad50 zinc hook motif	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,Rad50_zn_hook,SbcCD_C
k59_1288360_2	926569.ANT_14070	6.3e-53	175.0	COG2120@1|root,COG2120@2|Bacteria,2G6W3@200795|Chloroflexi	200795|Chloroflexi	S	PFAM LmbE family protein	-	-	3.5.1.115	ko:K18455	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
k59_1747928_2	1033806.HTIA_1915	1.53e-06	50.4	COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,23T61@183963|Halobacteria	183963|Halobacteria	P	COG0474 Cation transport ATPase	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_1802668_1	1035308.AQYY01000001_gene2447	1.35e-27	115.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UIEA@1239|Firmicutes,25EJM@186801|Clostridia,2642N@186807|Peptococcaceae	186801|Clostridia	GT	Pyruvate phosphate dikinase, PEP pyruvate binding	ppdK	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1395331_1	378806.STAUR_3241	5.65e-22	99.8	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,42QCV@68525|delta/epsilon subdivisions,2WJP8@28221|Deltaproteobacteria,2YUBA@29|Myxococcales	28221|Deltaproteobacteria	S	Putative modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_632282_1	367299.JOEE01000013_gene3124	3.23e-09	58.9	COG2801@1|root,COG2801@2|Bacteria,2GNRT@201174|Actinobacteria,4FGYS@85021|Intrasporangiaceae	201174|Actinobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve
k59_515387_1	717785.HYPMC_0741	2.97e-96	289.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,2TTC7@28211|Alphaproteobacteria,3N6F2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_692802_1	1049564.TevJSym_bo00190	2.69e-92	297.0	COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,1RQ9A@1236|Gammaproteobacteria,1J616@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	ko:K02569	-	-	-	-	ko00000	-	-	-	Cytochrom_NNT,EB_dh
k59_752040_1	713587.THITH_09660	4.27e-69	235.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1WX1Z@135613|Chromatiales	135613|Chromatiales	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_1396551_1	113395.AXAI01000002_gene5221	1.39e-90	286.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,3JUF5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	phbC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
k59_1691818_1	1247726.MIM_c26930	3.27e-07	51.2	COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,2VIXE@28216|Betaproteobacteria,3T1CT@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT,ACT_6,Formyl_trans_N
k59_1691818_2	247634.GPB2148_3371	3.05e-17	83.6	COG3828@1|root,COG3828@2|Bacteria,1RHWH@1224|Proteobacteria	1224|Proteobacteria	S	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
k59_1572777_1	1121405.dsmv_3031	6.71e-72	242.0	COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MN5Z@213118|Desulfobacterales	28221|Deltaproteobacteria	CK	Acetyltransferase (GNAT) domain	-	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_633320_1	1210884.HG799464_gene10364	1.62e-68	214.0	COG3335@1|root,COG3335@2|Bacteria,2IZSH@203682|Planctomycetes	203682|Planctomycetes	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_574247_1	367299.JOEE01000008_gene443	3.54e-80	250.0	COG0349@1|root,COG0349@2|Bacteria,2GKNM@201174|Actinobacteria,4FEWV@85021|Intrasporangiaceae	201174|Actinobacteria	J	3'-5' exonuclease	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
k59_165077_1	177437.HRM2_10730	1.52e-56	187.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MI0N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1572788_1	1320556.AVBP01000028_gene24	5.57e-98	309.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2TS9E@28211|Alphaproteobacteria,43H8H@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_1221551_1	1168065.DOK_07389	1.36e-44	153.0	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,1J4PE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	2.1.1.200	ko:K02533,ko:K15396	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
k59_1221554_1	590998.Celf_3037	3.08e-33	129.0	COG1216@1|root,COG1216@2|Bacteria,2IG08@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyltransferase, group 2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_641441_1	243233.MCA1366	1.28e-09	62.0	2DRM4@1|root,33C8W@2|Bacteria,1NQ8K@1224|Proteobacteria,1SGVH@1236|Gammaproteobacteria,1XFRG@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_641441_2	987059.RBXJA2T_12142	4.6e-58	192.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,1KJCV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1812117_1	1267005.KB911255_gene3004	9.88e-32	112.0	2E7H7@1|root,33EKK@2|Bacteria,1NIUX@1224|Proteobacteria,2UJWB@28211|Alphaproteobacteria,3N7EU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1812117_2	670307.HYPDE_28568	2.12e-49	164.0	COG1280@1|root,COG1280@2|Bacteria,1N227@1224|Proteobacteria,2UCZW@28211|Alphaproteobacteria,3N8KX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Lysine exporter protein LysE YggA	-	-	-	-	-	-	-	-	-	-	-	-	LysE
k59_1231681_1	177437.HRM2_01360	5.73e-86	254.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,42SHQ@68525|delta/epsilon subdivisions,2WP9W@28221|Deltaproteobacteria,2MK3D@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Ferric uptake regulator family	-	-	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_1166217_1	1499967.BAYZ01000073_gene2050	6.19e-51	172.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD,HAD_2,Hydrolase,Hydrolase_like
k59_1166217_2	397290.C810_02950	2.17e-14	73.2	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia,27T92@186928|unclassified Lachnospiraceae	186801|Clostridia	S	DNA polymerase alpha chain like domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
k59_641447_2	987059.RBXJA2T_07408	4.41e-63	202.0	COG2863@1|root,COG2863@2|Bacteria,1RCAT@1224|Proteobacteria,2VR47@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_174911_1	494419.ALPM01000070_gene1689	1.78e-37	143.0	COG3271@1|root,COG3271@2|Bacteria,2H973@201174|Actinobacteria	201174|Actinobacteria	M	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I36,Transglycosylas,VCBS
k59_880386_1	96561.Dole_3250	2.05e-61	201.0	COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,42S7X@68525|delta/epsilon subdivisions,2WNJ2@28221|Deltaproteobacteria,2MJG4@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_522324_1	987059.RBXJA2T_03247	2.88e-91	290.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,1KJ5X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1812138_1	172088.AUGA01000140_gene4660	6.17e-48	171.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2TVGG@28211|Alphaproteobacteria,3JSIB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_349988_1	460265.Mnod_0174	8.75e-103	323.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,1JRXS@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_1640029_1	1149133.ppKF707_3299	2.02e-29	118.0	COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,1RSJC@1236|Gammaproteobacteria,1YERK@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_1812147_1	876044.IMCC3088_2093	2.04e-25	103.0	COG2010@1|root,COG3245@1|root,COG2010@2|Bacteria,COG3245@2|Bacteria,1QVK1@1224|Proteobacteria,1RYEK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrome_CBB3
k59_1812147_2	754477.Q7C_1121	9.57e-181	531.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,4603G@72273|Thiotrichales	72273|Thiotrichales	L	it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction	rep	-	3.6.4.12	ko:K03656	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_232751_1	264198.Reut_B4057	9.41e-77	246.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VKYV@28216|Betaproteobacteria,1K09C@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	clsA	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
k59_1701972_1	765913.ThidrDRAFT_2321	8.85e-77	240.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1WW30@135613|Chromatiales	135613|Chromatiales	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
k59_466094_2	1463901.JOIY01000023_gene5205	8.76e-10	60.8	COG1309@1|root,COG1309@2|Bacteria,2GX8K@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1231741_1	1049564.TevJSym_ab00830	1.42e-64	203.0	COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,1S4KI@1236|Gammaproteobacteria,1J6WH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_1640060_1	590998.Celf_2503	1.55e-40	138.0	COG2456@1|root,COG2456@2|Bacteria,2GQZ0@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2304)	-	-	-	ko:K09153	-	-	-	-	ko00000	-	-	-	DUF2304
k59_1640060_2	446469.Sked_08960	2.33e-24	98.2	COG1216@1|root,COG1216@2|Bacteria,2I2J1@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyltransferase, group 2 family protein	ycbB	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1701996_1	1500894.JQNN01000001_gene1635	2.93e-55	185.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2VHJY@28216|Betaproteobacteria,472C7@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_880467_1	448385.sce3234	1.33e-63	220.0	COG1061@1|root,COG3886@1|root,COG1061@2|Bacteria,COG3886@2|Bacteria,1MV9F@1224|Proteobacteria,42NS1@68525|delta/epsilon subdivisions,2WQXY@28221|Deltaproteobacteria,2YWZQ@29|Myxococcales	28221|Deltaproteobacteria	KL	Domain of unknown function (DUF3427)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3427,Helicase_C,PLDc_2,ResIII
k59_701827_1	595536.ADVE02000001_gene2737	3.78e-32	124.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2TQJ7@28211|Alphaproteobacteria,36XV9@31993|Methylocystaceae	28211|Alphaproteobacteria	P	Peroxidase	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_1812211_2	880072.Desac_2736	9.32e-10	62.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MR1B@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	CoA binding domain	acs	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1054405_1	1081640.AGFU01000012_gene1331	4.95e-05	43.5	COG2076@1|root,COG2076@2|Bacteria,1MZ6P@1224|Proteobacteria,2UBR4@28211|Alphaproteobacteria,2K583@204457|Sphingomonadales	204457|Sphingomonadales	P	Small Multidrug Resistance protein	-	-	-	ko:K11741	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
k59_1054405_2	1121381.JNIV01000015_gene1715	6.4e-33	117.0	COG2076@1|root,COG2076@2|Bacteria	2|Bacteria	P	Multidrug Resistance protein	ykkD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046618,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K11741,ko:K18925	-	M00712	-	-	ko00000,ko00002,ko02000	2.A.7.1,2.A.7.1.5	-	-	Multi_Drug_Res
k59_582489_1	930169.B5T_04446	3.64e-68	222.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,1XI7M@135619|Oceanospirillales	135619|Oceanospirillales	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_1465459_1	1123355.JHYO01000002_gene1234	1.15e-32	127.0	COG0265@1|root,COG3016@1|root,COG0265@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,2U3QW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	pdz dhr glgf	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg,PDZ_2
k59_522408_1	1123519.PSJM300_07190	1.6e-24	101.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,1Z0ND@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	E	COG0436 Aspartate tyrosine aromatic aminotransferase	dapC	-	2.6.1.17	ko:K14261,ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_522408_2	396588.Tgr7_1152	1.02e-37	133.0	COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,1RPCS@1236|Gammaproteobacteria,1WVX8@135613|Chromatiales	135613|Chromatiales	E	Belongs to the transferase hexapeptide repeat family	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
k59_350075_1	391625.PPSIR1_35372	5.97e-97	306.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,42YZ6@68525|delta/epsilon subdivisions,2WU2X@28221|Deltaproteobacteria,2YXQD@29|Myxococcales	28221|Deltaproteobacteria	E	FAD dependent oxidoreductase central domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
k59_1054434_1	985255.APHJ01000021_gene1632	6.28e-07	53.9	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1HX2H@117743|Flavobacteriia	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_1054434_2	87626.PTD2_14752	1.14e-38	144.0	COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,1RPEQ@1236|Gammaproteobacteria,2Q15P@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
k59_762058_1	1156937.MFUM_1080005	8.57e-59	197.0	COG0105@1|root,COG0105@2|Bacteria,46T8K@74201|Verrucomicrobia,37G1K@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	F	Nucleoside diphosphate kinase	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
k59_524239_1	948106.AWZT01000022_gene3692	4.96e-62	212.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,1K20S@119060|Burkholderiaceae	28216|Betaproteobacteria	I	acyl-CoA dehydrogenase	fadE	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_703580_2	1122611.KB903959_gene4233	4.32e-89	276.0	COG4177@1|root,COG4177@2|Bacteria	2|Bacteria	E	L-phenylalanine transmembrane transporter activity	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_643290_1	395493.BegalDRAFT_3532	1.55e-05	47.4	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,4600H@72273|Thiotrichales	72273|Thiotrichales	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_643290_2	153948.NAL212_0680	7.1e-63	201.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2VKP0@28216|Betaproteobacteria,372US@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Protein of unknown function (DUF692)	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
k59_1641355_1	1049564.TevJSym_ad00260	1.43e-110	332.0	COG1008@1|root,COG1008@2|Bacteria,1R8V8@1224|Proteobacteria,1RZVG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	overlaps another CDS with the same product name	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_703588_1	1488328.JMCL01000011_gene208	6.15e-33	128.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_703588_2	1121921.KB898706_gene3351	9.37e-26	102.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,2PNGM@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	M	rRNA small subunit methyltransferase G	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
k59_234671_1	1267005.KB911257_gene904	1.4e-77	242.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2TT75@28211|Alphaproteobacteria,3N6NQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Glycerol-3-phosphate dehydrogenase	gpsA	GO:0003674,GO:0003824,GO:0006072,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_1407653_1	1329516.JPST01000005_gene1418	1.34e-88	270.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,4H9YB@91061|Bacilli,27B9Q@186824|Thermoactinomycetaceae	91061|Bacilli	E	Oligopeptide/dipeptide transporter, C-terminal region	appF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_643303_1	1049564.TevJSym_am00160	1.32e-89	286.0	COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,1RSJC@1236|Gammaproteobacteria,1J9QI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_810671_1	863365.XHC_0448	4.41e-25	102.0	COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,1RXYM@1236|Gammaproteobacteria,1X3GY@135614|Xanthomonadales	135614|Xanthomonadales	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006084,GO:0006139,GO:0006163,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009117,GO:0009150,GO:0009259,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019442,GO:0019637,GO:0019693,GO:0019752,GO:0020037,GO:0022607,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051186,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072521,GO:0097159,GO:1901135,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
k59_234694_1	436229.JOEH01000016_gene7209	1.22e-65	209.0	COG1451@1|root,COG1451@2|Bacteria,2GMP6@201174|Actinobacteria,2NFR1@228398|Streptacidiphilus	201174|Actinobacteria	S	SprT-like family	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
k59_234694_2	1123065.ATWL01000005_gene1202	1.25e-55	190.0	COG0476@1|root,COG0476@2|Bacteria,2GMJI@201174|Actinobacteria	201174|Actinobacteria	H	UBA ThiF-type NAD FAD binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
k59_703618_1	1380391.JIAS01000015_gene111	7.06e-126	371.0	COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,2U1M9@28211|Alphaproteobacteria,2JYEI@204441|Rhodospirillales	204441|Rhodospirillales	M	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	Dala_Dala_lig_C
k59_1168889_1	999550.KI421507_gene815	5.89e-17	84.7	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2TRNX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_1584339_1	220341.16502491	1.04e-41	144.0	COG1842@1|root,COG1842@2|Bacteria,1NC7S@1224|Proteobacteria,1RS0G@1236|Gammaproteobacteria,3ZJJV@590|Salmonella	1236|Gammaproteobacteria	KT	PspA/IM30 family	pspA	GO:0003674,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0008289,GO:0009266,GO:0009271,GO:0009408,GO:0009605,GO:0009607,GO:0009615,GO:0009628,GO:0009889,GO:0009898,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019897,GO:0019898,GO:0031234,GO:0031323,GO:0031326,GO:0042802,GO:0043167,GO:0043168,GO:0043207,GO:0043433,GO:0044092,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0050896,GO:0051090,GO:0051171,GO:0051252,GO:0051704,GO:0051707,GO:0060187,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0098552,GO:0098562,GO:0098586,GO:1903506,GO:2000112,GO:2001141	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
k59_468727_1	1165841.SULAR_06123	2.48e-100	308.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2YMRM@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_524317_1	690850.Desaf_0817	8.85e-74	228.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,42PTR@68525|delta/epsilon subdivisions,2WJDG@28221|Deltaproteobacteria,2M9HR@213115|Desulfovibrionales	28221|Deltaproteobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_524317_2	690850.Desaf_0818	1.22e-08	55.5	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,42M3F@68525|delta/epsilon subdivisions,2WJ32@28221|Deltaproteobacteria,2M7V3@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_1814814_1	931626.Awo_c20260	1.11e-16	84.7	COG3434@1|root,COG3434@2|Bacteria,1TPWC@1239|Firmicutes,248M1@186801|Clostridia,25YRR@186806|Eubacteriaceae	186801|Clostridia	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,HDOD
k59_1759058_1	1144342.PMI40_00647	1.57e-13	80.1	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria,473WU@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	LysM domain	fimV	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	LysM
k59_352092_1	196367.JNFG01000073_gene6229	6.09e-139	407.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria,1KH1R@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_234726_1	519989.ECTPHS_06952	2.69e-25	109.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1WW15@135613|Chromatiales	135613|Chromatiales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_1584355_1	861299.J421_1321	7.64e-68	216.0	COG0115@1|root,COG0115@2|Bacteria,1ZTH5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_352101_1	471857.Svir_36260	1.62e-45	157.0	COG1408@1|root,COG1408@2|Bacteria,2GJHT@201174|Actinobacteria,4DXIU@85010|Pseudonocardiales	201174|Actinobacteria	S	Calcineurin-like phosphoesterase superfamily domain	ykuE	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
k59_1466943_1	870187.Thini_2792	3.77e-62	204.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,4600H@72273|Thiotrichales	72273|Thiotrichales	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_1466943_2	1469245.JFBG01000070_gene54	9.06e-10	57.4	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1WVXJ@135613|Chromatiales	135613|Chromatiales	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
k59_1814840_1	1499967.BAYZ01000085_gene5185	9.98e-05	50.1	COG0438@1|root,COG0438@2|Bacteria,2NPA0@2323|unclassified Bacteria	2|Bacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
k59_1584369_1	686340.Metal_0731	1.11e-100	304.0	COG3391@1|root,COG3391@2|Bacteria,1MXDX@1224|Proteobacteria,1S012@1236|Gammaproteobacteria,1XDJS@135618|Methylococcales	135618|Methylococcales	S	56kDa selenium binding protein (SBP56)	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
k59_810730_1	1219077.VAZ01S_072_00200	3.01e-24	101.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1XTP8@135623|Vibrionales	135623|Vibrionales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_810730_2	1049564.TevJSym_by00040	2.93e-14	70.5	COG2888@1|root,COG2888@2|Bacteria,1PBSM@1224|Proteobacteria,1SWH0@1236|Gammaproteobacteria,1JBN5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Zinc-ribbon containing domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1451
k59_1814855_1	261292.Nit79A3_2210	9.82e-73	231.0	COG1344@1|root,COG1344@2|Bacteria,1PJUJ@1224|Proteobacteria,2VM4I@28216|Betaproteobacteria,371W9@32003|Nitrosomonadales	28216|Betaproteobacteria	N	Bacterial flagellin N-terminal helical region	flgL	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
k59_524370_1	1122604.JONR01000007_gene2808	3.69e-59	196.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,1RREX@1236|Gammaproteobacteria,1X3WI@135614|Xanthomonadales	135614|Xanthomonadales	C	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit	-	-	-	-	-	-	-	-	-	-	-	-	E1_dh,OxoDH_E1alpha_N
k59_524370_2	1121935.AQXX01000093_gene3417	2.09e-101	302.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,1XHJM@135619|Oceanospirillales	135619|Oceanospirillales	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	bkdA2	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_1641439_1	1051613.XP_003000654.1	1.66e-11	69.7	COG1131@1|root,KOG0059@2759|Eukaryota,38BPG@33154|Opisthokonta,3PBDP@4751|Fungi,3QM77@4890|Ascomycota,211N8@147550|Sordariomycetes,1F6SX@1028384|Glomerellales	4751|Fungi	Q	ATP-binding cassette sub-family A member 9	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3,ABC_tran
k59_1759101_1	257313.BP2173	7.96e-78	247.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2VHRH@28216|Betaproteobacteria,3T1KE@506|Alcaligenaceae	28216|Betaproteobacteria	C	cytochrome c oxidase	ccoG	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
k59_643413_1	95619.PM1_0205690	2.5e-44	163.0	COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,1RMMI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	pilS	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS_8
k59_1759114_1	367299.JOEE01000003_gene2896	2.29e-84	268.0	COG4907@1|root,COG4907@2|Bacteria,2GNW7@201174|Actinobacteria,4FEME@85021|Intrasporangiaceae	201174|Actinobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
k59_524389_1	102125.Xen7305DRAFT_00039580	9.91e-26	102.0	2E5SP@1|root,330H2@2|Bacteria,1GEVC@1117|Cyanobacteria	1117|Cyanobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_524390_1	1267005.KB911255_gene2615	3.87e-107	316.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2TRBW@28211|Alphaproteobacteria,3N64I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_810762_1	670307.HYPDE_38873	4.52e-43	152.0	COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2U6K4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG0631 Serine threonine protein phosphatase	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
k59_1814915_1	1366050.N234_26610	4.86e-65	221.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,1K38N@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Phospholipase D Transphosphatidylase	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_764719_1	765912.Thimo_1819	7.58e-21	92.8	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1WW4U@135613|Chromatiales	135613|Chromatiales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_530033_1	1267005.KB911255_gene2513	6.82e-51	182.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TT3Z@28211|Alphaproteobacteria,3N6MB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Peptidase M23	MA20_20375	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1294191_1	338963.Pcar_2556	3.08e-06	48.5	COG3063@1|root,COG3063@2|Bacteria,1QZ5S@1224|Proteobacteria,42XK8@68525|delta/epsilon subdivisions,2WSKB@28221|Deltaproteobacteria,43V3K@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1294191_2	198628.Dda3937_03716	2.61e-77	252.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,2JD3E@204037|Dickeya	1236|Gammaproteobacteria	L	SMART helicase c2	yoaA	GO:0003674,GO:0003824,GO:0004386,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070035,GO:0071704,GO:0090304,GO:1901360	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
k59_1234497_1	545264.KB898749_gene115	9.88e-65	213.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1WXQX@135613|Chromatiales	135613|Chromatiales	L	DNA photolyase	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_471285_1	717785.HYPMC_3268	2.02e-14	72.0	COG2916@1|root,COG2916@2|Bacteria,1N801@1224|Proteobacteria,2UF4Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	DNA-binding protein, H-NS	hvrA	-	-	ko:K03746	-	-	-	-	ko00000,ko03036,ko03400	-	-	-	Histone_HNS
k59_647449_1	1532557.JL37_16185	3.83e-152	439.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VIT6@28216|Betaproteobacteria,3T3CV@506|Alcaligenaceae	28216|Betaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabF2	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_647449_2	757424.Hsero_3715	5.95e-71	220.0	COG1028@1|root,COG1028@2|Bacteria,1MUPY@1224|Proteobacteria,2VK19@28216|Betaproteobacteria,4733Z@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	KR domain	fabG2	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_177777_1	1109445.AGSX01000063_gene811	2.2e-31	120.0	COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,1RYUT@1236|Gammaproteobacteria,1Z0FQ@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Heme d1 biosynthesis protein NirF	nirF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K19345	-	-	-	-	ko00000	-	-	-	Cytochrom_D1
k59_177777_2	287.DR97_3485	1.04e-25	99.8	COG2010@1|root,COG2010@2|Bacteria,1N73U@1224|Proteobacteria,1SFGZ@1236|Gammaproteobacteria,1YK2T@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	nirC	-	-	ko:K19344	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3
k59_177777_3	1267005.KB911258_gene311	5.22e-07	53.1	COG0007@1|root,COG0007@2|Bacteria,1RCCD@1224|Proteobacteria,2U66R@28211|Alphaproteobacteria,3N9EI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	cobA	-	2.1.1.107	ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000	-	-	-	TP_methylase
k59_354889_1	305900.GV64_16165	9.34e-119	353.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1XHYF@135619|Oceanospirillales	135619|Oceanospirillales	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_1058589_1	1380354.JIAN01000009_gene3800	4.18e-68	216.0	COG4965@1|root,COG4965@2|Bacteria,2I3KW@201174|Actinobacteria,4F1N2@85016|Cellulomonadaceae	201174|Actinobacteria	U	PFAM Type II secretion system F domain	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
k59_1410551_1	1207076.ALAT01000215_gene4140	3.62e-105	321.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1Z2EC@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	NU	General secretion pathway protein E	xpsE	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_412558_2	365528.KB891219_gene813	5.43e-18	80.5	2EBYF@1|root,335XS@2|Bacteria,2IJ54@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_942070_1	207559.Dde_1257	1.04e-16	79.7	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2WJXY@28221|Deltaproteobacteria,2M826@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_942070_2	644968.DFW101_0012	3.58e-58	186.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,42M2J@68525|delta/epsilon subdivisions,2WJMH@28221|Deltaproteobacteria,2M84J@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240,ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10,Fer4_8
k59_647924_1	617140.AJZE01000034_gene2766	6.54e-18	81.3	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1XT5G@135623|Vibrionales	135623|Vibrionales	E	Histidine biosynthesis bifunctional protein HisIE	hisI	GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19,3.6.1.31	ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
k59_647924_2	1286106.MPL1_03168	1.19e-26	109.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,45ZSQ@72273|Thiotrichales	72273|Thiotrichales	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_1176279_1	1304883.KI912532_gene365	7.59e-66	212.0	COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,2VKYR@28216|Betaproteobacteria,2KW1I@206389|Rhodocyclales	206389|Rhodocyclales	T	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
k59_412988_1	1487921.DP68_02605	1.76e-105	313.0	COG0057@1|root,COG0057@2|Bacteria,1VTBP@1239|Firmicutes,24C88@186801|Clostridia	186801|Clostridia	G	Dihydrodipicolinate reductase, N-terminus	-	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N,Gp_dh_C
k59_62118_1	349521.HCH_06418	6.26e-15	71.2	COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,1S6WD@1236|Gammaproteobacteria,1XKI8@135619|Oceanospirillales	135619|Oceanospirillales	O	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein	dsbB	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
k59_62118_2	713586.KB900536_gene2511	5.14e-82	251.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1WW2B@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
k59_942690_1	987059.RBXJA2T_19024	1.21e-95	294.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,1KIZS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	PFAM FAD linked oxidase domain protein	glcD	-	1.1.2.4,1.1.3.15,1.1.5.12	ko:K00102,ko:K00104,ko:K03777	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475,R00704,R11591	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_471780_3	1284352.AOIG01000022_gene3799	5.88e-16	73.9	2BJ5J@1|root,32DEU@2|Bacteria,1U1FE@1239|Firmicutes,4IAXP@91061|Bacilli,273BU@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF2829)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2829
k59_1235019_1	349124.Hhal_1786	8.87e-41	149.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1WWQT@135613|Chromatiales	135613|Chromatiales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
k59_1294917_1	933262.AXAM01000062_gene955	2.67e-107	314.0	COG3640@1|root,COG3640@2|Bacteria,1RB02@1224|Proteobacteria,42NBP@68525|delta/epsilon subdivisions,2WKS7@28221|Deltaproteobacteria,2MJA2@213118|Desulfobacterales	28221|Deltaproteobacteria	D	PFAM Cobyrinic acid ac-diamide synthase	cooC	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
k59_355596_1	391008.Smal_0404	3.04e-51	180.0	COG4943@1|root,COG4943@2|Bacteria,1MVTH@1224|Proteobacteria,1RMDP@1236|Gammaproteobacteria,1X4HG@135614|Xanthomonadales	135614|Xanthomonadales	T	signal transduction protein containing sensor and EAL domains	-	-	-	-	-	-	-	-	-	-	-	-	CSS-motif,EAL
k59_647930_1	237727.NAP1_00435	6.95e-15	79.7	COG4916@1|root,COG4916@2|Bacteria,1QUPG@1224|Proteobacteria,2TW35@28211|Alphaproteobacteria,2K7GA@204457|Sphingomonadales	204457|Sphingomonadales	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
k59_1059130_2	1236902.ANAS01000004_gene3718	5.36e-08	52.4	COG3602@1|root,COG3602@2|Bacteria,2IM16@201174|Actinobacteria,4EPV9@85012|Streptosporangiales	201174|Actinobacteria	S	ACT domain	-	-	-	ko:K09964	-	-	-	-	ko00000	-	-	-	ACT_3,ACT_7,Acetyltransf_1
k59_62135_1	1121406.JAEX01000005_gene2870	3.65e-75	233.0	COG2204@1|root,COG2204@2|Bacteria,1RCHU@1224|Proteobacteria,42QWT@68525|delta/epsilon subdivisions,2WN23@28221|Deltaproteobacteria,2MAFK@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,STAS,STAS_2
k59_119645_2	471853.Bcav_3669	3.67e-181	523.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the amidase family	amiB	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_119645_3	1032480.MLP_47490	6.73e-06	48.5	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4DNX8@85009|Propionibacteriales	201174|Actinobacteria	G	Glycosyl hydrolase family 65 central catalytic domain	-	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
k59_237361_1	987059.RBXJA2T_19086	7.47e-72	224.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2VHXJ@28216|Betaproteobacteria,1KJ75@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	PFAM Electron transfer flavoprotein alpha beta-subunit	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_706690_1	504472.Slin_3449	4.55e-32	125.0	COG0763@1|root,COG0763@2|Bacteria,4NDW3@976|Bacteroidetes,47JDC@768503|Cytophagia	976|Bacteroidetes	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
k59_884008_1	493475.GARC_0527	1.06e-49	163.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,1S3QR@1236|Gammaproteobacteria,467AX@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2	slyD	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
k59_884008_2	247634.GPB2148_3265	4.3e-18	80.9	COG1225@1|root,COG1225@2|Bacteria,1MZN4@1224|Proteobacteria	1224|Proteobacteria	O	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_1294929_1	1121289.JHVL01000018_gene581	2.06e-05	52.8	COG3857@1|root,COG3857@2|Bacteria,1TQJW@1239|Firmicutes,2487T@186801|Clostridia,36EE8@31979|Clostridiaceae	186801|Clostridia	L	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD-helicase,UvrD_C
k59_765150_1	314278.NB231_06611	2.47e-22	90.5	COG5433@1|root,COG5433@2|Bacteria,1RAHU@1224|Proteobacteria,1S1TZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc,DUF4338
k59_295747_1	1123251.ATWM01000003_gene1169	7.6e-05	51.2	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4FEWD@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_295747_2	1121094.KB894661_gene2745	1.28e-78	251.0	COG3049@1|root,COG3049@2|Bacteria,4NK0D@976|Bacteroidetes,2G2FC@200643|Bacteroidia,4AVY6@815|Bacteroidaceae	976|Bacteroidetes	M	Linear amide C-N hydrolase, choloylglycine hydrolase family protein	-	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	CBAH
k59_413010_1	1454010.JEOE01000036_gene2909	2.67e-133	388.0	COG2873@1|root,COG2873@2|Bacteria,2I2EB@201174|Actinobacteria,4F0PD@85016|Cellulomonadaceae	201174|Actinobacteria	E	TIGRFAM O-acetylhomoserine O-acetylserine sulfhydrylase	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_2953_1	1415754.JQMK01000005_gene1826	2.45e-59	191.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,465JZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_530572_1	754477.Q7C_2409	1.43e-47	156.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,460DF@72273|Thiotrichales	72273|Thiotrichales	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_530572_2	396595.TK90_2156	1.64e-36	126.0	COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,1S62N@1236|Gammaproteobacteria,1WYNJ@135613|Chromatiales	135613|Chromatiales	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
k59_355625_2	762211.BSTEL_1890	7.95e-14	78.6	COG0545@1|root,COG0545@2|Bacteria,2GJK2@201174|Actinobacteria,4CZEF@85004|Bifidobacteriales	201174|Actinobacteria	M	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
k59_1646126_1	247639.MGP2080_04950	1.69e-14	78.2	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,1RNY6@1236|Gammaproteobacteria,1JAB2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG3202 ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	MFS_1,TLC
k59_823893_1	414684.RC1_1718	2.39e-136	400.0	COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,2TRTR@28211|Alphaproteobacteria,2JR46@204441|Rhodospirillales	204441|Rhodospirillales	Q	Homospermidine synthase	hss	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_823893_2	1254432.SCE1572_32740	9.38e-15	74.7	COG0625@1|root,COG3631@1|root,COG0625@2|Bacteria,COG3631@2|Bacteria,1N3UG@1224|Proteobacteria	1224|Proteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
k59_530577_1	1454004.AW11_02882	2.64e-134	395.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,2VMP0@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Pfam Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_1823204_1	1123392.AQWL01000001_gene1509	1.64e-73	229.0	COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,2VRSR@28216|Betaproteobacteria,1KSTT@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Predicted membrane protein (DUF2238)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2238
k59_2969_1	743299.Acife_2323	3.45e-84	262.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_1294957_1	713586.KB900536_gene3059	3.82e-129	382.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales	135613|Chromatiales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_1294957_2	187272.Mlg_1950	5.59e-47	157.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria,1WY8Z@135613|Chromatiales	135613|Chromatiales	S	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
k59_119672_1	1137269.AZWL01000001_gene5373	1.73e-22	98.2	COG2197@1|root,COG2197@2|Bacteria,2I8Y7@201174|Actinobacteria	201174|Actinobacteria	KT	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg,Sigma70_r4_2
k59_884046_2	187272.Mlg_1342	4.73e-19	85.9	COG3086@1|root,COG3086@2|Bacteria,1N6QS@1224|Proteobacteria,1SCTM@1236|Gammaproteobacteria,1WYRU@135613|Chromatiales	135613|Chromatiales	T	PFAM Positive regulator of sigma(E), RseC MucC	-	-	-	ko:K03803	-	-	-	-	ko00000,ko03021	-	-	-	RseC_MucC
k59_1117449_1	765912.Thimo_0735	1.96e-106	314.0	COG1443@1|root,COG1443@2|Bacteria,1QXSY@1224|Proteobacteria,1RPX8@1236|Gammaproteobacteria,1WWCS@135613|Chromatiales	135613|Chromatiales	I	pfam nudix	-	-	-	-	-	-	-	-	-	-	-	-	DUF4743,NUDIX
k59_1117449_2	1123367.C666_14885	3.15e-70	225.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2VID7@28216|Betaproteobacteria,2KUBR@206389|Rhodocyclales	206389|Rhodocyclales	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_942755_2	1184609.KILIM_014_00150	8.02e-05	44.3	COG0607@1|root,COG0607@2|Bacteria,2IQIP@201174|Actinobacteria,4F834@85018|Dermatophilaceae	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_178323_1	639030.JHVA01000001_gene2588	5.54e-70	226.0	COG5361@1|root,COG5361@2|Bacteria,3Y6F7@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1235065_1	159087.Daro_3824	2.51e-90	280.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2VIE4@28216|Betaproteobacteria,2M02H@206389|Rhodocyclales	206389|Rhodocyclales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1000066_1	56780.SYN_00351	8.49e-47	166.0	COG1456@1|root,COG1456@2|Bacteria,1R6BH@1224|Proteobacteria,42NKF@68525|delta/epsilon subdivisions,2WJ72@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase delta subunit, TIM barrel	-	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD
k59_884062_1	396588.Tgr7_2900	1.94e-40	160.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_1763233_1	1286106.MPL1_03568	1.57e-40	142.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1RQ1J@1236|Gammaproteobacteria,460UF@72273|Thiotrichales	72273|Thiotrichales	K	PFAM Response regulator receiver domain	-	-	-	ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_1763235_1	1163617.SCD_n01730	3.47e-72	238.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJI0@28216|Betaproteobacteria	28216|Betaproteobacteria	P	von Willebrand factor (vWF) type A domain	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA_2
k59_823910_2	909663.KI867150_gene213	1.08e-47	174.0	COG0457@1|root,COG0457@2|Bacteria,1NNJ6@1224|Proteobacteria,42PBD@68525|delta/epsilon subdivisions,2WKWJ@28221|Deltaproteobacteria,2MRCI@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
k59_706744_1	1274.HX89_00300	3.95e-126	366.0	COG3335@1|root,COG3335@2|Bacteria,2GJQI@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_29,HTH_32
k59_1352408_1	1384054.N790_08870	5.69e-75	232.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,1X316@135614|Xanthomonadales	135614|Xanthomonadales	KT	Two component response regulator for the phosphate regulon	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_355687_1	1198452.Jab_1c24790	2.56e-113	338.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2VI3U@28216|Betaproteobacteria,4734Z@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_942803_1	196490.AUEZ01000003_gene3790	2.32e-48	175.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,2TR2R@28211|Alphaproteobacteria,3JS2X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Penicillin-Binding Protein C-terminus Family	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
k59_1295014_2	95619.PM1_0217455	6.03e-54	180.0	COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	RNA polymerase sigma	rpoS	GO:0000988,GO:0000990,GO:0001000,GO:0001121,GO:0001123,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_884098_1	443152.MDG893_14590	1.14e-77	240.0	COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,1RMUT@1236|Gammaproteobacteria,46757@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	GO:0003674,GO:0003824,GO:0004766,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0010487,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0043918,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	iECED1_1282.ECED1_0125,iPC815.YPO3411,iSDY_1059.SDY_0028	Spermine_synt_N,Spermine_synth
k59_413073_1	335659.S23_36440	0.000104	49.7	COG2207@1|root,COG2207@2|Bacteria,1Q3UX@1224|Proteobacteria,2U3Z0@28211|Alphaproteobacteria,3JY8K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K04033	-	-	-	-	ko00000,ko03000	-	-	-	HTH_18
k59_355713_1	420662.Mpe_A1782	4.7e-78	244.0	COG3239@1|root,COG3239@2|Bacteria,1MUHK@1224|Proteobacteria,2VSCY@28216|Betaproteobacteria,1KMN1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
k59_1352426_1	314278.NB231_16118	5.58e-61	197.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,1RMYQ@1236|Gammaproteobacteria,1WXFV@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
k59_237443_1	572477.Alvin_3053	3.96e-33	125.0	COG1418@1|root,COG1418@2|Bacteria,1RH6M@1224|Proteobacteria,1T4T1@1236|Gammaproteobacteria,1X2TR@135613|Chromatiales	135613|Chromatiales	S	mRNA catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_3027_1	1541065.JRFE01000006_gene4873	2.05e-35	138.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1GBKP@1117|Cyanobacteria,3VJFV@52604|Pleurocapsales	1117|Cyanobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,Response_reg
k59_62259_1	396588.Tgr7_3124	6.93e-230	658.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,1WWBM@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
k59_1176391_1	1255043.TVNIR_1860	5.31e-147	428.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WW29@135613|Chromatiales	135613|Chromatiales	S	PFAM Uncharacterised protein family UPF0027	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_594222_1	1499967.BAYZ01000172_gene5776	5.26e-70	235.0	COG1198@1|root,COG1198@2|Bacteria,2NNQ3@2323|unclassified Bacteria	2|Bacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_1241113_1	1469245.JFBG01000007_gene674	5.9e-73	236.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RN6P@1236|Gammaproteobacteria,1X2DA@135613|Chromatiales	135613|Chromatiales	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
k59_1533256_1	1232410.KI421426_gene1458	1.64e-95	310.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43U04@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_891141_1	570952.ATVH01000015_gene1533	1.51e-16	78.6	COG1309@1|root,COG1309@2|Bacteria,1RC7C@1224|Proteobacteria,2U5YR@28211|Alphaproteobacteria,2JSGT@204441|Rhodospirillales	204441|Rhodospirillales	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_245080_1	1283284.AZUK01000001_gene1607	2.41e-24	101.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1Y3DU@135624|Aeromonadales	135624|Aeromonadales	L	DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_1830453_1	768671.ThimaDRAFT_4229	5.97e-89	270.0	COG0697@1|root,COG0697@2|Bacteria,1RJFE@1224|Proteobacteria,1RZF0@1236|Gammaproteobacteria,1WWYW@135613|Chromatiales	135613|Chromatiales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1830453_2	517417.Cpar_0855	3.96e-06	50.8	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1FD6X@1090|Chlorobi	1090|Chlorobi	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_1302290_1	545276.KB898724_gene1847	1.97e-60	202.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,1RPBT@1236|Gammaproteobacteria,1WWHF@135613|Chromatiales	135613|Chromatiales	EGP	Major facilitator superfamily	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
k59_476836_1	768671.ThimaDRAFT_2779	9.97e-33	126.0	COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1WXNS@135613|Chromatiales	135613|Chromatiales	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA_2
k59_476836_2	1120968.AUBX01000012_gene2686	0.000103	48.9	COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,4NFAQ@976|Bacteroidetes	976|Bacteroidetes	S	PFAM von Willebrand factor type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	TPR_2,TPR_6,TPR_8,VWA_2
k59_183472_1	1348657.M622_16960	7.95e-48	171.0	COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,2VPRW@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Protein of unknown function (DUF1302)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1302
k59_891148_1	396588.Tgr7_1337	5.47e-27	106.0	COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,1RMZ2@1236|Gammaproteobacteria,1WWDH@135613|Chromatiales	135613|Chromatiales	D	Belongs to the ParA family	-	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	CbiA,ParA
k59_891148_2	323261.Noc_2157	2.68e-81	256.0	COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,1RMUU@1236|Gammaproteobacteria,1WXF1@135613|Chromatiales	135613|Chromatiales	N	PFAM GTP-binding signal recognition particle SRP54 G- domain	-	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
k59_1302291_2	593907.Celgi_1873	1.3e-63	201.0	COG2141@1|root,COG2141@2|Bacteria,2GPA5@201174|Actinobacteria,4F27Z@85016|Cellulomonadaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1591706_1	240292.Ava_4661	4.04e-10	59.3	COG3259@1|root,COG3259@2|Bacteria,1G1C8@1117|Cyanobacteria,1HMGB@1161|Nostocales	1117|Cyanobacteria	C	Coenzyme F420-reducing hydrogenase, alpha subunit	hoxH	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	iJN678.hoxH	NiFeSe_Hases
k59_1591706_2	1140.Synpcc7942_2556	2.39e-40	139.0	COG1941@1|root,COG1941@2|Bacteria,1G2I6@1117|Cyanobacteria,1H097@1129|Synechococcus	1117|Cyanobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	hoxY	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	iJN678.hoxY	Oxidored_q6
k59_950145_1	1167006.UWK_00109	3.26e-43	159.0	COG0123@1|root,COG0454@1|root,COG0123@2|Bacteria,COG0456@2|Bacteria,1MU7P@1224|Proteobacteria,42NAQ@68525|delta/epsilon subdivisions,2WJPX@28221|Deltaproteobacteria,2MK5E@213118|Desulfobacterales	28221|Deltaproteobacteria	BKQ	Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Hist_deacetyl
k59_1651324_1	342113.DM82_5106	1.94e-64	212.0	COG1226@1|root,COG1226@2|Bacteria,1MXQP@1224|Proteobacteria,2VKI7@28216|Betaproteobacteria,1K4XJ@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Ion transport 2 domain protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
k59_1121584_2	1193181.BN10_640012	2.9e-39	155.0	COG4585@1|root,COG4585@2|Bacteria,2GIXR@201174|Actinobacteria,4FEFW@85021|Intrasporangiaceae	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_1181515_1	1452536.JARE01000028_gene3484	6.93e-13	73.9	COG3653@1|root,COG3653@2|Bacteria,2I8X9@201174|Actinobacteria,4FTKJ@85023|Microbacteriaceae	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_11394_1	933262.AXAM01000004_gene2356	3.71e-96	308.0	COG0574@1|root,COG0745@1|root,COG0574@2|Bacteria,COG0745@2|Bacteria,1N38V@1224|Proteobacteria,42MWC@68525|delta/epsilon subdivisions,2WKAZ@28221|Deltaproteobacteria,2MICZ@213118|Desulfobacterales	28221|Deltaproteobacteria	GT	pyruvate phosphate dikinase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2,PPDK_N
k59_362949_1	1480694.DC28_11295	4.89e-80	253.0	COG1816@1|root,COG1816@2|Bacteria	2|Bacteria	F	deaminase activity	add	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
k59_950157_1	1273125.Rrhod_0812	2.62e-47	166.0	COG0415@1|root,COG0415@2|Bacteria,2GJXU@201174|Actinobacteria,4FWSP@85025|Nocardiaceae	201174|Actinobacteria	L	Belongs to the DNA photolyase family	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_1476175_1	378806.STAUR_2245	3.66e-53	182.0	COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,42PFG@68525|delta/epsilon subdivisions,2WKPM@28221|Deltaproteobacteria,2YTUX@29|Myxococcales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	ndh2	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_362950_2	393595.ABO_0947	3.24e-123	388.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1XH98@135619|Oceanospirillales	135619|Oceanospirillales	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_535674_1	998674.ATTE01000001_gene2454	2.94e-157	455.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,46096@72273|Thiotrichales	72273|Thiotrichales	C	Belongs to the heme-copper respiratory oxidase family	cyoB	-	1.10.3.10,1.9.3.1	ko:K02274,ko:K02298	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081,R11335	RC00016,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX1
k59_535674_2	326297.Sama_3483	1.12e-33	128.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,2Q8ZR@267890|Shewanellaceae	1236|Gammaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
k59_183498_1	717785.HYPMC_0878	2.14e-131	393.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,3N69N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Methylmalonyl-CoA mutase	mutB	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
k59_594258_1	483219.LILAB_23505	1.23e-16	84.7	COG2311@1|root,COG2311@2|Bacteria,1RI24@1224|Proteobacteria,42ZYC@68525|delta/epsilon subdivisions,2X468@28221|Deltaproteobacteria,2YYC6@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF418)	-	-	-	ko:K07148	-	-	-	-	ko00000	-	-	-	DUF418
k59_1241165_1	1210884.HG799464_gene10820	9.75e-50	173.0	COG1233@1|root,COG1233@2|Bacteria,2IYPF@203682|Planctomycetes	203682|Planctomycetes	Q	COG1233 Phytoene dehydrogenase and related	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_1709431_1	316057.RPD_4250	1.33e-43	152.0	COG2391@1|root,COG2391@2|Bacteria,1MWWP@1224|Proteobacteria,2TQW4@28211|Alphaproteobacteria,3JWT9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Sulphur transport	-	-	-	-	-	-	-	-	-	-	-	-	Sulf_transp
k59_1121598_1	1123073.KB899243_gene470	1.87e-26	112.0	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1X4MQ@135614|Xanthomonadales	135614|Xanthomonadales	NU	Tfp pilus assembly protein FimV	fimV	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	TPR_19
k59_300852_1	247633.GP2143_00182	4.11e-71	233.0	COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,1J4Z4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	lipoprotein	lpoA	GO:0000270,GO:0003674,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	-	ko:K07121	-	-	-	-	ko00000	-	-	-	LppC
k59_69473_1	545276.KB898727_gene415	1.41e-84	258.0	COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,1RMUT@1236|Gammaproteobacteria,1WX1H@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
k59_1065419_1	485915.Dret_1750	1.32e-65	222.0	COG0021@1|root,COG0021@2|Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_N,XFP,XFP_N
k59_1591740_1	1169152.AXVD01000006_gene3511	1.44e-09	58.9	COG3559@1|root,COG3559@2|Bacteria,2I5T7@201174|Actinobacteria,4G9V1@85025|Nocardiaceae	201174|Actinobacteria	M	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_1591740_2	1464048.JNZS01000007_gene4560	3.24e-102	308.0	COG4152@1|root,COG4152@2|Bacteria,2I2U6@201174|Actinobacteria,4DMD2@85008|Micromonosporales	201174|Actinobacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	AAA_21,ABC_tran,DUF4162
k59_1065431_1	366649.XFF4834R_chr17130	1.32e-18	84.7	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,1X56M@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
k59_1065431_2	1123279.ATUS01000001_gene2540	1.68e-16	77.0	COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,1J6HX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	integral membrane protein	yggT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
k59_1181550_1	1134474.O59_002021	4.18e-90	284.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1FGXV@10|Cellvibrio	1236|Gammaproteobacteria	O	Hsp90 protein	htpG	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006974,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
k59_1533315_1	1167006.UWK_00074	4.81e-95	286.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42M55@68525|delta/epsilon subdivisions,2WIKM@28221|Deltaproteobacteria,2MJ60@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM domain protein	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
k59_653138_1	983917.RGE_35100	2.94e-68	231.0	COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,2VP0G@28216|Betaproteobacteria,1KPIE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_124802_1	1510531.JQJJ01000008_gene4124	1.92e-77	248.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_183527_1	1397528.Q671_08645	7.56e-122	362.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,1XH6E@135619|Oceanospirillales	135619|Oceanospirillales	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_769327_1	1123070.KB899252_gene965	3.5e-68	224.0	COG1530@1|root,COG1530@2|Bacteria,46S5S@74201|Verrucomicrobia,2ITMW@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Ribonuclease E/G family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
k59_1651380_1	1255043.TVNIR_1766	5.78e-132	384.0	COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,1RSIM@1236|Gammaproteobacteria,1WW7Y@135613|Chromatiales	135613|Chromatiales	C	reductase, dissimilatory-type alpha subunit	-	-	1.8.99.5	ko:K11180	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_300874_1	106582.XP_004540648.1	8e-14	76.3	KOG0575@1|root,KOG0575@2759|Eukaryota,38FF0@33154|Opisthokonta,3B9H9@33208|Metazoa,3CZ7U@33213|Bilateria,480U8@7711|Chordata,4985C@7742|Vertebrata,49PW1@7898|Actinopterygii	33208|Metazoa	T	Polo-like kinase 4 (Drosophila)	PLK4	GO:0000003,GO:0000086,GO:0000226,GO:0000278,GO:0000280,GO:0000803,GO:0001578,GO:0001701,GO:0001741,GO:0001890,GO:0001892,GO:0003006,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005730,GO:0005737,GO:0005813,GO:0005814,GO:0005815,GO:0005829,GO:0005856,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006928,GO:0006996,GO:0007010,GO:0007017,GO:0007049,GO:0007098,GO:0007099,GO:0007140,GO:0007275,GO:0007276,GO:0007281,GO:0007283,GO:0007286,GO:0007288,GO:0007346,GO:0008150,GO:0008152,GO:0009790,GO:0009792,GO:0009888,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010389,GO:0010564,GO:0010604,GO:0010638,GO:0010824,GO:0010825,GO:0015630,GO:0016020,GO:0016043,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019222,GO:0019538,GO:0019953,GO:0022402,GO:0022406,GO:0022412,GO:0022414,GO:0022607,GO:0030030,GO:0030031,GO:0030154,GO:0030317,GO:0030855,GO:0031023,GO:0031647,GO:0031974,GO:0031981,GO:0032153,GO:0032154,GO:0032155,GO:0032501,GO:0032502,GO:0032504,GO:0032886,GO:0033043,GO:0033301,GO:0035082,GO:0035186,GO:0036211,GO:0040007,GO:0040011,GO:0042176,GO:0042802,GO:0043009,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044450,GO:0044459,GO:0044464,GO:0044703,GO:0044770,GO:0044772,GO:0044782,GO:0044839,GO:0045448,GO:0045732,GO:0045787,GO:0046599,GO:0046601,GO:0046605,GO:0046607,GO:0046777,GO:0048232,GO:0048285,GO:0048468,GO:0048513,GO:0048515,GO:0048518,GO:0048522,GO:0048568,GO:0048589,GO:0048608,GO:0048609,GO:0048731,GO:0048856,GO:0048869,GO:0048870,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051179,GO:0051246,GO:0051247,GO:0051298,GO:0051321,GO:0051493,GO:0051495,GO:0051640,GO:0051641,GO:0051674,GO:0051704,GO:0051726,GO:0060255,GO:0060271,GO:0060429,GO:0060706,GO:0060707,GO:0061458,GO:0065007,GO:0065008,GO:0070013,GO:0070507,GO:0070925,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090068,GO:0097711,GO:0097722,GO:0097742,GO:0098534,GO:0098535,GO:0098536,GO:0098590,GO:0120031,GO:0120036,GO:0140013,GO:0140056,GO:0140096,GO:1901564,GO:1901987,GO:1901990,GO:1902115,GO:1902117,GO:1902749,GO:1903046,GO:1903047,GO:1903251	2.7.11.21	ko:K08863	ko04068,map04068	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03036	-	-	-	POLO_box,Pkinase
k59_124809_1	1121405.dsmv_0948	2.18e-65	225.0	COG0764@1|root,COG3321@1|root,COG0764@2|Bacteria,COG3321@2|Bacteria,1QUWM@1224|Proteobacteria,43BRB@68525|delta/epsilon subdivisions,2WJJ6@28221|Deltaproteobacteria,2MI1Q@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Acyltransferase,FabA,KAsynt_C_assoc,Ketoacyl-synt_C,PS-DH,ketoacyl-synt
k59_69505_1	768671.ThimaDRAFT_2736	2.98e-33	117.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,1WYPW@135613|Chromatiales	135613|Chromatiales	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
k59_476907_2	1121459.AQXE01000002_gene1440	2.94e-14	71.6	COG0503@1|root,COG0503@2|Bacteria,1Q8TB@1224|Proteobacteria,42Y2J@68525|delta/epsilon subdivisions,2WSX1@28221|Deltaproteobacteria,2MB7N@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	-	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
k59_1652082_1	996637.SGM_4150	2.37e-85	266.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_246498_1	1247649.D560_2281	1.29e-78	248.0	COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2VIP8@28216|Betaproteobacteria,3T2UP@506|Alcaligenaceae	28216|Betaproteobacteria	I	PHB de-polymerase C-terminus	phaZ	-	3.1.1.75	ko:K05973	ko00650,map00650	-	R05118	-	ko00000,ko00001,ko01000	-	-	-	PHB_depo_C
k59_1417284_1	1537715.JQFJ01000002_gene1249	2.22e-29	119.0	COG4782@1|root,COG4782@2|Bacteria,1MVAD@1224|Proteobacteria,2TTCR@28211|Alphaproteobacteria,2K84S@204457|Sphingomonadales	204457|Sphingomonadales	S	Alpha/beta hydrolase of unknown function (DUF900)	-	-	-	-	-	-	-	-	-	-	-	-	DUF900
k59_1592351_2	1122207.MUS1_11690	9.5e-23	97.8	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1XI6U@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_1122174_1	335543.Sfum_1235	2.14e-58	192.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42P7N@68525|delta/epsilon subdivisions,2WJKE@28221|Deltaproteobacteria,2MQY8@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PFAM Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1122174_2	330214.NIDE4127	7.99e-10	59.3	COG1185@1|root,COG1185@2|Bacteria,3J0DX@40117|Nitrospirae	40117|Nitrospirae	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_363903_1	557599.MKAN_01050	6.42e-34	124.0	2DQ16@1|root,334AZ@2|Bacteria,2IMJY@201174|Actinobacteria,23A9M@1762|Mycobacteriaceae	201174|Actinobacteria	S	SpoIIAA-like	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
k59_363903_3	85643.Tmz1t_2482	1.94e-41	144.0	COG1278@1|root,COG3326@1|root,COG1278@2|Bacteria,COG3326@2|Bacteria,1N6YM@1224|Proteobacteria,2VQXP@28216|Betaproteobacteria,2KX2F@206389|Rhodocyclales	206389|Rhodocyclales	K	Protein of unknown function (DUF1294)	-	-	-	-	-	-	-	-	-	-	-	-	CSD,DUF1294
k59_653833_1	880072.Desac_0433	1.02e-56	186.0	COG0589@1|root,COG0589@2|Bacteria,1N6DC@1224|Proteobacteria,42UXA@68525|delta/epsilon subdivisions,2WQF5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1066724_1	1502770.JQMG01000001_gene1710	1.5e-59	198.0	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2VHCR@28216|Betaproteobacteria,2KKWV@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_1417295_2	1286631.X805_06400	1.44e-47	167.0	COG0683@1|root,COG0683@2|Bacteria,1MWH7@1224|Proteobacteria,2VI1S@28216|Betaproteobacteria,1KIW0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	branched-chain amino acid	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_951126_1	1121935.AQXX01000138_gene3174	2.99e-39	146.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1XHDN@135619|Oceanospirillales	135619|Oceanospirillales	FP	Belongs to the GppA Ppx family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
k59_301484_1	471855.Shel_26870	0.000126	45.4	COG1641@1|root,COG1641@2|Bacteria,2I8J1@201174|Actinobacteria,4CV08@84998|Coriobacteriia	84998|Coriobacteriia	S	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes	larC	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
k59_301484_2	438753.AZC_2758	3.45e-12	66.2	COG0438@1|root,COG0438@2|Bacteria,1MWSZ@1224|Proteobacteria,2TQQK@28211|Alphaproteobacteria,3F062@335928|Xanthobacteraceae	28211|Alphaproteobacteria	M	Glycosyltransferase Family 4	MA20_17390	-	2.4.1.348	ko:K12995	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
k59_594871_1	1042377.AFPJ01000036_gene1233	9.52e-116	353.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_1477191_1	1035308.AQYY01000001_gene3228	9.08e-36	135.0	COG1150@1|root,COG1150@2|Bacteria,1V8UM@1239|Firmicutes,24J4U@186801|Clostridia,2622W@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_8
k59_1533980_1	999541.bgla_1g06560	2.29e-74	236.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VISA@28216|Betaproteobacteria,1K19D@119060|Burkholderiaceae	28216|Betaproteobacteria	C	glycolate oxidase (Iron-sulfur subunit)	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7,Fer4_8
k59_1004850_1	1384054.N790_04595	4.13e-29	115.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1X4EZ@135614|Xanthomonadales	135614|Xanthomonadales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_1004850_2	472759.Nhal_3210	1e-166	476.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,1WX6R@135613|Chromatiales	135613|Chromatiales	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_769872_1	933262.AXAM01000016_gene192	2.97e-58	191.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,42PMQ@68525|delta/epsilon subdivisions,2WKB8@28221|Deltaproteobacteria,2MIF9@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Transcriptional regulator, LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_712554_1	795666.MW7_0317	1.23e-108	326.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,1K2B7@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3,OmpA
k59_363920_1	1172188.KB911821_gene2013	3.34e-52	184.0	COG4425@1|root,COG4425@2|Bacteria,2IBWT@201174|Actinobacteria,4FEUJ@85021|Intrasporangiaceae	201174|Actinobacteria	S	Alpha/beta-hydrolase family N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_9,Abhydrolase_9_N
k59_1652094_1	643562.Daes_1584	0.0	1295.0	COG0603@1|root,COG0603@2|Bacteria,1MXFU@1224|Proteobacteria,42T68@68525|delta/epsilon subdivisions,2WS4G@28221|Deltaproteobacteria,2MC6S@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	PP-loop superfamily ATPase	-	-	-	-	-	-	-	-	-	-	-	-	QueC
k59_1652094_2	643562.Daes_1583	1.06e-183	511.0	293DJ@1|root,2ZQW1@2|Bacteria,1RE56@1224|Proteobacteria,42ZFY@68525|delta/epsilon subdivisions,2WUVQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1652094_3	643562.Daes_1582	3.4e-31	110.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,42PQG@68525|delta/epsilon subdivisions,2WMMB@28221|Deltaproteobacteria,2M80Q@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response)	-	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_892149_1	471853.Bcav_2885	2.32e-185	549.0	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria	201174|Actinobacteria	T	UPF0182 protein	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_653848_1	717785.HYPMC_0056	8.29e-66	221.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,2TR2R@28211|Alphaproteobacteria,3N6A8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	penicillin-binding protein	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
k59_1066750_1	631362.Thi970DRAFT_03481	2.26e-85	267.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1WVXY@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_1182276_1	2340.JV46_13970	2.24e-120	359.0	COG1249@1|root,COG1249@2|Bacteria,1MXQ3@1224|Proteobacteria,1RQ44@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_892153_2	1500257.JQNM01000007_gene1565	3.94e-12	67.4	COG0510@1|root,COG0510@2|Bacteria,1N77Z@1224|Proteobacteria,2TRW6@28211|Alphaproteobacteria,4BC1M@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Choline/ethanolamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH,Choline_kinase
k59_1537605_1	247633.GP2143_07909	1.07e-16	80.5	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1J5XC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_1537605_2	566466.NOR53_2184	1.42e-156	447.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1J9FE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	ATPase family associated with various cellular activities (AAA)	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_253696_1	1123368.AUIS01000032_gene1399	1.12e-45	157.0	COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,1RNSP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_1072171_1	472759.Nhal_3536	1.17e-26	112.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1WXGJ@135613|Chromatiales	1236|Gammaproteobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_1125413_1	439235.Dalk_0544	5.1e-46	175.0	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG2198@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2MPM4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,PilJ,Response_reg,dCache_1
k59_20109_1	1397527.Q670_07730	4.19e-66	215.0	COG1943@1|root,COG1943@2|Bacteria,1MVUV@1224|Proteobacteria,1RNIV@1236|Gammaproteobacteria,1XIG5@135619|Oceanospirillales	135619|Oceanospirillales	L	COG1943 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_657853_1	518766.Rmar_2616	1.21e-88	281.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1FIS9@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	PFAM glycoside hydrolase family 3 domain protein	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_1713609_1	195105.CN97_11610	2.51e-113	340.0	COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2TR59@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_1772098_1	1380354.JIAN01000005_gene1245	5.8e-31	120.0	COG2223@1|root,COG2223@2|Bacteria,2GJ1I@201174|Actinobacteria,4F0H3@85016|Cellulomonadaceae	201174|Actinobacteria	P	PFAM major facilitator superfamily MFS_1	narU	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	iNJ661.Rv0267	MFS_1
k59_956416_1	1249627.D779_1382	7.8e-108	323.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1WX4T@135613|Chromatiales	135613|Chromatiales	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_956416_2	768671.ThimaDRAFT_0897	2.18e-47	162.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria,1WWMC@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
k59_1421297_1	446466.Cfla_1154	6.91e-124	370.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4F0T5@85016|Cellulomonadaceae	201174|Actinobacteria	G	SMART alpha amylase catalytic sub domain	malL	-	3.2.1.10	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R01718,R01791,R06199	RC00028,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3459,Malt_amylase_C
k59_1596007_1	408672.NBCG_01580	2.13e-08	55.5	COG4961@1|root,COG4961@2|Bacteria,2I36X@201174|Actinobacteria,4DRYX@85009|Propionibacteriales	201174|Actinobacteria	U	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	TadE
k59_253715_1	351607.Acel_1011	1.71e-73	238.0	COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,4ERUC@85013|Frankiales	201174|Actinobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1186337_1	768671.ThimaDRAFT_1325	2.48e-69	222.0	COG1249@1|root,COG1249@2|Bacteria,1MXQ3@1224|Proteobacteria,1RQ44@1236|Gammaproteobacteria,1X080@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1186337_2	396588.Tgr7_1541	1.48e-23	99.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1WX54@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_833683_1	765912.Thimo_3326	3.09e-130	397.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1WWXC@135613|Chromatiales	135613|Chromatiales	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_481263_1	984262.SGRA_3443	8.94e-37	126.0	COG4327@1|root,COG4327@2|Bacteria,4NSV7@976|Bacteroidetes	976|Bacteroidetes	S	solute sodium symporter, small subunit	-	-	-	-	-	-	-	-	-	-	-	-	DUF4212
k59_1362088_2	383381.EH30_01810	1.46e-32	124.0	COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2TVJ7@28211|Alphaproteobacteria,2K0I0@204457|Sphingomonadales	204457|Sphingomonadales	L	COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
k59_897962_1	455632.SGR_5165	1.27e-62	215.0	COG0477@1|root,COG1846@1|root,COG0477@2|Bacteria,COG1846@2|Bacteria,2GJ09@201174|Actinobacteria,418GD@629295|Streptomyces griseus group	201174|Actinobacteria	EGKP	Fungal trichothecene efflux pump (TRI12)	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_834065_1	545276.KB898727_gene453	2.24e-86	279.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales	135613|Chromatiales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_1309106_2	1121106.JQKB01000042_gene2462	9.37e-46	160.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U8MD@28211|Alphaproteobacteria,2JT55@204441|Rhodospirillales	204441|Rhodospirillales	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_1483221_1	243365.CV_3396	5.78e-49	169.0	COG0500@1|root,COG2226@2|Bacteria,1NJBJ@1224|Proteobacteria,2VPXH@28216|Betaproteobacteria,2KTPH@206351|Neisseriales	206351|Neisseriales	H	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_188636_1	519989.ECTPHS_02511	1.27e-69	222.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1WWAV@135613|Chromatiales	135613|Chromatiales	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_1072924_1	1123065.ATWL01000017_gene2035	1.98e-67	227.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria	201174|Actinobacteria	M	penicillin-binding protein	pbp5	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
k59_422918_2	396588.Tgr7_3011	7.76e-82	253.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1WX49@135613|Chromatiales	135613|Chromatiales	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
k59_598789_1	1278308.KB907076_gene1608	1.29e-17	80.1	COG3622@1|root,COG3622@2|Bacteria,2GKPC@201174|Actinobacteria,4FP8I@85023|Microbacteriaceae	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.22,5.3.1.35	ko:K01816,ko:K22131	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
k59_598789_2	1384056.N787_10935	5.86e-40	137.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,1S5YQ@1236|Gammaproteobacteria,1X6MZ@135614|Xanthomonadales	135614|Xanthomonadales	J	Protein chain release factor B	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
k59_1309113_1	1453501.JELR01000002_gene104	1.75e-10	67.4	COG3325@1|root,COG3979@1|root,COG3325@2|Bacteria,COG3979@2|Bacteria,1MWAR@1224|Proteobacteria,1RPNS@1236|Gammaproteobacteria,4672D@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Glyco_18	chiA	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	CBM_5_12,ChitinaseA_N,Glyco_hydro_18,REJ
k59_76187_1	1121438.JNJA01000002_gene3346	1.41e-103	313.0	COG1453@1|root,COG1453@2|Bacteria,1RAU3@1224|Proteobacteria,42RA5@68525|delta/epsilon subdivisions,2WMXQ@28221|Deltaproteobacteria,2M8PQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1072939_1	1313421.JHBV01000025_gene1048	2.46e-23	102.0	COG3250@1|root,COG3250@2|Bacteria,4NE9C@976|Bacteroidetes	976|Bacteroidetes	G	PFAM Vitamin K-dependent gamma-carboxylase	-	-	-	-	-	-	-	-	-	-	-	-	VKG_Carbox
k59_658292_2	710421.Mycch_2937	9.14e-64	215.0	COG3559@1|root,COG3559@2|Bacteria	2|Bacteria	M	Exporter of polyketide antibiotics	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_369727_1	862514.HMPREF0623_1716	3.93e-17	84.3	COG0664@1|root,COG0664@2|Bacteria,1V3XW@1239|Firmicutes,4HDG1@91061|Bacilli,3F4YM@33958|Lactobacillaceae	91061|Bacilli	K	Transcriptional regulator, Crp Fnr family	rcfA	-	-	ko:K21562	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_1421721_1	1249627.D779_4215	1.96e-49	180.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1WWWW@135613|Chromatiales	135613|Chromatiales	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
k59_1483245_1	1249627.D779_1294	1.22e-156	449.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,1RQ3D@1236|Gammaproteobacteria,1WWR9@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
k59_305491_2	58123.JOFJ01000002_gene2528	2.55e-20	90.9	COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria	201174|Actinobacteria	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_773347_1	396588.Tgr7_2294	3.84e-85	268.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1WXE2@135613|Chromatiales	135613|Chromatiales	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_716923_1	1123065.ATWL01000005_gene1280	1.2e-126	370.0	COG0112@1|root,COG0112@2|Bacteria,2GK7U@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006563,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009069,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019752,GO:0019842,GO:0020012,GO:0030170,GO:0030312,GO:0030682,GO:0036094,GO:0042133,GO:0042783,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044464,GO:0046983,GO:0048037,GO:0050662,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0071944,GO:0075136,GO:0097159,GO:1901363,GO:1901564,GO:1901605	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_188659_1	1267005.KB911256_gene1812	2.73e-93	281.0	COG3820@1|root,COG3820@2|Bacteria,1MVR2@1224|Proteobacteria,2TT8Z@28211|Alphaproteobacteria,3N6PJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1013)	MA20_20925	-	-	ko:K09987	-	-	-	-	ko00000	-	-	-	DUF1013
k59_254271_1	768671.ThimaDRAFT_1443	4.82e-71	224.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,1RNXH@1236|Gammaproteobacteria,1WW4N@135613|Chromatiales	135613|Chromatiales	C	PFAM aldo keto reductase	tas	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_20713_1	298654.FraEuI1c_7019	2.16e-26	100.0	COG3585@1|root,COG3585@2|Bacteria,2IKQV@201174|Actinobacteria,4ET46@85013|Frankiales	201174|Actinobacteria	H	DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,MerR,TOBE
k59_20713_2	452652.KSE_62350	3.58e-15	75.5	COG0725@1|root,COG0725@2|Bacteria,2GMPF@201174|Actinobacteria,2M1SC@2063|Kitasatospora	201174|Actinobacteria	P	Bacterial extracellular solute-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
k59_305496_2	455632.SGR_4912	2.52e-39	138.0	COG1268@1|root,COG1268@2|Bacteria,2GJ53@201174|Actinobacteria,417XV@629295|Streptomyces griseus group	201174|Actinobacteria	S	BioY family	bioY	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
k59_1309145_1	1267005.KB911263_gene1335	5.51e-78	242.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2TSMS@28211|Alphaproteobacteria,3N6K3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
k59_129991_1	1125863.JAFN01000001_gene634	3.19e-98	293.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW8A@1224|Proteobacteria,42RGI@68525|delta/epsilon subdivisions,2WNGP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_33
k59_540533_1	768671.ThimaDRAFT_4705	1.66e-90	283.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria,1WWCP@135613|Chromatiales	135613|Chromatiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_1072975_2	1127673.GLIP_2700	2.04e-39	147.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_658309_1	644282.Deba_0869	7.12e-22	97.4	COG1149@1|root,COG1149@2|Bacteria,1QWNA@1224|Proteobacteria,43BT8@68525|delta/epsilon subdivisions,2X73X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
k59_1186769_2	1122132.AQYH01000008_gene2713	1.65e-40	137.0	COG1320@1|root,COG1320@2|Bacteria,1N3BA@1224|Proteobacteria,2UDGG@28211|Alphaproteobacteria,4BFKY@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Na+/H+ antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_1186769_3	880073.Calab_2015	5.27e-19	80.5	COG1563@1|root,COG1563@2|Bacteria,2NRSK@2323|unclassified Bacteria	2|Bacteria	P	Domain of unknown function (DUF4040)	mnhB	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB
k59_1186769_4	1122132.AQYH01000008_gene2715	2.1e-07	48.9	COG2212@1|root,COG2212@2|Bacteria,1PTJ0@1224|Proteobacteria,2UF98@28211|Alphaproteobacteria,4BGKC@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Multiple resistance and pH regulation protein F (MrpF / PhaF)	-	-	-	-	-	-	-	-	-	-	-	-	MrpF_PhaF
k59_1656536_1	439235.Dalk_4738	4.85e-122	378.0	COG0532@1|root,COG3064@1|root,COG0532@2|Bacteria,COG3064@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2MIGT@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_898017_1	1230476.C207_03195	2.07e-58	196.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,3JTQK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Sigma-54 interaction domain	flbD	-	-	ko:K10943	ko02020,ko05111,map02020,map05111	M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_598821_1	953739.SVEN_3349	2.15e-34	122.0	2CC1Y@1|root,32TCV@2|Bacteria,2IQEP@201174|Actinobacteria	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	wblA	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
k59_540543_1	1089550.ATTH01000001_gene993	4.43e-31	124.0	COG2821@1|root,COG2821@2|Bacteria	2|Bacteria	M	peptidoglycan turnover	mltA	GO:0000270,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016787,GO:0016798,GO:0019867,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043170,GO:0044425,GO:0044459,GO:0044462,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	iECABU_c1320.ECABU_c30840	3D,MltA
k59_369776_2	748658.KB907315_gene2470	6.19e-92	276.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1WX9S@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_1596520_2	313628.LNTAR_08919	2.2e-24	99.0	COG1076@1|root,COG1076@2|Bacteria	2|Bacteria	O	ATPase activator activity	djlA	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
k59_369779_1	338963.Pcar_2557	1.63e-90	290.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,42Q00@68525|delta/epsilon subdivisions,2WJEM@28221|Deltaproteobacteria,43UHA@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Bifunctional transglycosylase second domain	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
k59_1837419_2	379731.PST_1855	5.58e-59	203.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1YZRS@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_1362154_1	2340.JV46_17590	3.85e-54	173.0	2BE3G@1|root,327U6@2|Bacteria,1RI7X@1224|Proteobacteria,1S88B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_898050_1	880072.Desac_0324	5.74e-67	214.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,42PDR@68525|delta/epsilon subdivisions,2WJ60@28221|Deltaproteobacteria,2MQVX@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	PFAM HhH-GPD superfamily base excision DNA repair protein	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
k59_1538111_1	1123240.ATVO01000004_gene991	4.6e-69	223.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,2K0AI@204457|Sphingomonadales	204457|Sphingomonadales	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_834129_1	1047013.AQSP01000142_gene188	8.5e-39	139.0	COG1237@1|root,COG1237@2|Bacteria,2NPQA@2323|unclassified Bacteria	2|Bacteria	P	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Lactamase_B_2
k59_1362161_1	1122619.KB892335_gene951	6.09e-07	56.2	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2VH64@28216|Betaproteobacteria,3T2J6@506|Alcaligenaceae	28216|Betaproteobacteria	H	TonB-dependent Receptor Plug Domain	btuB	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
k59_716959_1	626887.J057_20620	1.94e-186	528.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,464FH@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_898058_1	1392838.AWNM01000068_gene1168	5.93e-09	55.5	COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,2VJ6G@28216|Betaproteobacteria,3T3RD@506|Alcaligenaceae	28216|Betaproteobacteria	S	Phospholipase/Carboxylesterase	estB	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
k59_898058_2	568706.BN118_1354	6.27e-77	234.0	COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,2VH28@28216|Betaproteobacteria,3T1IP@506|Alcaligenaceae	28216|Betaproteobacteria	H	Molybdenum cofactor biosynthesis protein MogA	mogA	-	2.7.7.75	ko:K03831	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
k59_658341_1	335543.Sfum_1165	1.84e-13	66.6	COG1149@1|root,COG1149@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	nifJ	-	1.18.1.2,1.19.1.1,1.2.7.1,1.2.7.3,1.3.7.1	ko:K00176,ko:K00528,ko:K03737,ko:K20449	ko00010,ko00020,ko00620,ko00650,ko00720,ko00760,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map00760,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00307,M00620	R01196,R01197,R03164,R10159,R10866	RC00004,RC02422,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,Pyr_redox_2,TPP_enzyme_C
k59_658341_2	880072.Desac_1831	2.59e-76	231.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,42QTS@68525|delta/epsilon subdivisions,2WN02@28221|Deltaproteobacteria,2MQC6@213462|Syntrophobacterales	28221|Deltaproteobacteria	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2496	GATase
k59_1714093_1	1255043.TVNIR_1821	3.8e-16	78.6	COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,1RMF1@1236|Gammaproteobacteria,1WXIP@135613|Chromatiales	135613|Chromatiales	E	Belongs to the agmatine deiminase family	aguA	-	-	-	-	-	-	-	-	-	-	-	PAD_porph
k59_1714093_2	523791.Kkor_1385	1.13e-18	81.3	2ENKU@1|root,33G87@2|Bacteria,1NMH6@1224|Proteobacteria,1SGDI@1236|Gammaproteobacteria,1XMTM@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1714093_3	765912.Thimo_2204	2.25e-60	195.0	COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,1RN28@1236|Gammaproteobacteria,1WW7E@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs	dusA	-	-	ko:K05539	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_1366746_2	1240349.ANGC01000004_gene1923	1.48e-18	88.2	COG0454@1|root,COG0456@2|Bacteria,2I9Y3@201174|Actinobacteria,4G0Z8@85025|Nocardiaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
k59_1777095_1	1255043.TVNIR_3177	4.88e-59	194.0	COG4328@1|root,COG4328@2|Bacteria,1Q8XR@1224|Proteobacteria,1TKCI@1236|Gammaproteobacteria,1X1VG@135613|Chromatiales	2|Bacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF429,RelA_SpoT
k59_904470_1	1123377.AUIV01000001_gene876	1.76e-90	278.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1X4R7@135614|Xanthomonadales	135614|Xanthomonadales	E	Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
k59_1366749_1	1396858.Q666_07690	1.75e-56	189.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,464IR@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iJN746.PP_5285,iSBO_1134.SBO_3641	DFP,Flavoprotein
k59_904477_1	1112217.PPL19_11202	1.57e-66	213.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	OU	Signal peptide peptidase	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_1315644_1	1249627.D779_1509	3.51e-35	130.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1WW90@135613|Chromatiales	135613|Chromatiales	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_1315644_2	1230343.CANP01000037_gene2681	1.61e-36	130.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,1RM7Y@1236|Gammaproteobacteria,1JCAJ@118969|Legionellales	118969|Legionellales	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_1843839_1	1265310.CCBD010000077_gene5318	1.91e-49	163.0	COG4119@1|root,COG4119@2|Bacteria,2IM6D@201174|Actinobacteria,238UM@1762|Mycobacteriaceae	201174|Actinobacteria	L	pfam nudix	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_1843839_2	3055.EDP03041	7.89e-23	91.3	COG3565@1|root,2RY6W@2759|Eukaryota,37UZF@33090|Viridiplantae,34KZ8@3041|Chlorophyta	3041|Chlorophyta	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_662854_1	648757.Rvan_3160	2.1e-104	311.0	COG2801@1|root,COG2801@2|Bacteria,1MVQ9@1224|Proteobacteria,2TTHG@28211|Alphaproteobacteria,3N7C9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	rve,rve_3
k59_544815_1	367299.JOEE01000002_gene2522	4.17e-86	265.0	COG1672@1|root,COG1672@2|Bacteria,2GWBV@201174|Actinobacteria,4FE3R@85021|Intrasporangiaceae	201174|Actinobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
k59_544815_2	471853.Bcav_0389	1.59e-29	117.0	COG0768@1|root,COG0768@2|Bacteria,2GJAM@201174|Actinobacteria	201174|Actinobacteria	M	penicillin-binding protein	pbp2B	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	MecA_N,PBP_dimer,Transpeptidase
k59_486163_1	1198232.CYCME_2235	2.57e-23	93.2	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,1S90Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	cytochrome	cycM	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_486163_2	234267.Acid_7805	3.45e-48	156.0	COG2346@1|root,COG2346@2|Bacteria,3Y8WS@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
k59_376235_2	235985.BBPN01000006_gene3577	3.7e-09	57.8	COG1261@1|root,COG1261@2|Bacteria,2HIQE@201174|Actinobacteria,2NIRU@228398|Streptacidiphilus	201174|Actinobacteria	NO	Chaperone for flagella basal body P-ring formation	-	-	-	-	-	-	-	-	-	-	-	-	ChapFlgA,SAF
k59_376235_4	33876.JNXY01000031_gene3113	1.91e-96	290.0	COG2856@1|root,COG2856@2|Bacteria,2IFJ3@201174|Actinobacteria,4DD12@85008|Micromonosporales	201174|Actinobacteria	E	IrrE N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M78
k59_376235_5	644283.Micau_6125	1.18e-06	54.3	COG4974@1|root,COG4974@2|Bacteria,2I4YF@201174|Actinobacteria,4DMUS@85008|Micromonosporales	201174|Actinobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
k59_1315653_1	1121935.AQXX01000129_gene1821	3.01e-70	230.0	COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1T2D4@1236|Gammaproteobacteria,1XRWB@135619|Oceanospirillales	135619|Oceanospirillales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,Response_reg
k59_1079981_3	396588.Tgr7_1241	5.37e-161	458.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,1WXNW@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
k59_1661213_1	159087.Daro_1557	3.89e-46	169.0	COG4105@1|root,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	bamD	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	YfiO
k59_963489_1	1266925.JHVX01000010_gene1321	9.84e-29	115.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,372B6@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	dppF	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1254094_1	485915.Dret_2002	4.58e-110	328.0	COG3464@1|root,COG3464@2|Bacteria,1R4DH@1224|Proteobacteria,43AQ4@68525|delta/epsilon subdivisions,2X63W@28221|Deltaproteobacteria,2MGXP@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM transposase IS204 IS1001 IS1096 IS1165 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,zf-ISL3
k59_193246_1	471853.Bcav_2175	6.82e-132	394.0	COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0040007,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_260357_1	1049564.TevJSym_at00270	4.86e-49	172.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1J4S5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	COG4942 Membrane-bound metallopeptidase	envC	GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_721514_1	1713.JOFV01000016_gene63	1.12e-111	327.0	COG0204@1|root,COG0204@2|Bacteria,2GJ6V@201174|Actinobacteria,4F0V1@85016|Cellulomonadaceae	201174|Actinobacteria	I	Phosphate acyltransferases	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_603331_1	744980.TRICHSKD4_1583	3.01e-115	341.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TSK3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1191357_1	1121403.AUCV01000001_gene964	2.56e-23	102.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2MI4H@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	TIGRFAM type IV-A pilus assembly ATPase PilB	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N,cNMP_binding
k59_1191357_2	395495.Lcho_0584	1.19e-15	77.4	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2VHQM@28216|Betaproteobacteria,1KIX5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_1542723_1	666685.R2APBS1_0793	2.08e-145	431.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,1RR88@1236|Gammaproteobacteria,1X51Q@135614|Xanthomonadales	135614|Xanthomonadales	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_721518_1	396588.Tgr7_2800	9.46e-73	234.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,1RMSZ@1236|Gammaproteobacteria,1X2PU@135613|Chromatiales	135613|Chromatiales	EGP	Drug resistance transporter Bcr CflA subfamily	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_1129854_1	1469245.JFBG01000061_gene2320	4.41e-08	53.5	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,1RPBB@1236|Gammaproteobacteria,1WWDZ@135613|Chromatiales	135613|Chromatiales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
k59_1129854_2	1125973.JNLC01000010_gene1237	1.35e-44	152.0	COG3963@1|root,COG3963@2|Bacteria,1N1KB@1224|Proteobacteria,2TVD9@28211|Alphaproteobacteria,3JRWY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Ribosomal RNA adenine dimethylase	pmtA	-	2.1.1.17,2.1.1.71	ko:K00570	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00091	R01320,R02056,R03424	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25,RrnaAD
k59_1080013_1	351348.Maqu_2460	7.89e-56	184.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,464CX@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_1080013_2	983545.Glaag_0838	7.02e-05	45.4	COG3116@1|root,COG3116@2|Bacteria,1N9MH@1224|Proteobacteria,1SC7P@1236|Gammaproteobacteria,46838@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsL	GO:0000003,GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0019954,GO:0022402,GO:0022414,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0043093,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944	-	ko:K03586	-	-	-	-	ko00000,ko03036	-	-	-	FtsL
k59_1426372_1	1713.JOFV01000008_gene3164	9.46e-97	292.0	COG3239@1|root,COG3239@2|Bacteria,2GJKF@201174|Actinobacteria,4F10Y@85016|Cellulomonadaceae	201174|Actinobacteria	I	PFAM fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
k59_777054_1	1048339.KB913029_gene108	3.42e-112	339.0	COG1274@1|root,COG1274@2|Bacteria,2GJH3@201174|Actinobacteria,4ES3C@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	-	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
k59_1718654_1	1146883.BLASA_4047	5.61e-05	45.1	COG3335@1|root,COG3335@2|Bacteria,2GK01@201174|Actinobacteria,4EV9T@85013|Frankiales	201174|Actinobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_1718654_2	1108045.GORHZ_127_00160	1.16e-71	219.0	COG3415@1|root,COG3415@2|Bacteria,2IJ34@201174|Actinobacteria	201174|Actinobacteria	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
k59_904531_1	1502852.FG94_00866	1.11e-31	119.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2VHW4@28216|Betaproteobacteria,473TR@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
k59_904531_2	1122599.AUGR01000024_gene1358	5.15e-16	73.2	COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,1S8S1@1236|Gammaproteobacteria,1XMS7@135619|Oceanospirillales	135619|Oceanospirillales	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
k59_904531_3	29581.BW37_03902	8.18e-32	116.0	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,2VRMG@28216|Betaproteobacteria,4741N@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Molybdopterin converting factor, large subunit	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
k59_486215_1	644076.SCH4B_1525	4.29e-52	181.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,4NBTU@97050|Ruegeria	28211|Alphaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_486215_2	1411123.JQNH01000001_gene1273	2.15e-07	48.9	2E7PS@1|root,3325B@2|Bacteria,1N7R7@1224|Proteobacteria,2UFCM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_603350_1	1121124.JNIX01000009_gene2855	2.33e-38	140.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2TR9N@28211|Alphaproteobacteria,2KFBG@204458|Caulobacterales	204458|Caulobacterales	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_603350_2	570967.JMLV01000001_gene2786	2.52e-06	47.0	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,2U77S@28211|Alphaproteobacteria,2JSR7@204441|Rhodospirillales	204441|Rhodospirillales	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
k59_1843904_1	317936.Nos7107_3725	2.39e-55	186.0	COG4292@1|root,COG4292@2|Bacteria,1G40Y@1117|Cyanobacteria,1HIDE@1161|Nostocales	1117|Cyanobacteria	S	PFAM Bacterial low temperature requirement A protein (LtrA)	-	-	-	-	-	-	-	-	-	-	-	-	LtrA
k59_544856_2	1283300.ATXB01000001_gene1077	1.59e-08	58.2	COG5488@1|root,COG5488@2|Bacteria,1N9B7@1224|Proteobacteria,1SF1J@1236|Gammaproteobacteria,1XGQI@135618|Methylococcales	135618|Methylococcales	S	Integral membrane protein (DUF2244)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2244
k59_1191379_1	1499967.BAYZ01000155_gene659	5.59e-56	197.0	COG3829@1|root,COG4251@1|root,COG3829@2|Bacteria,COG4251@2|Bacteria,2NR7U@2323|unclassified Bacteria	2|Bacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k59_838676_1	596151.DesfrDRAFT_2296	1.48e-09	60.8	COG1075@1|root,COG1075@2|Bacteria,1NIPT@1224|Proteobacteria	1224|Proteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_838676_2	768671.ThimaDRAFT_3183	2.35e-31	117.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1RQ1J@1236|Gammaproteobacteria,1WYUK@135613|Chromatiales	135613|Chromatiales	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_1426386_1	311402.Avi_4089	1.57e-22	105.0	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2TR45@28211|Alphaproteobacteria,4B8T7@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	tamB	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
k59_1777163_1	1242864.D187_008232	3.5e-116	343.0	2C57D@1|root,2Z7RS@2|Bacteria,1MX6G@1224|Proteobacteria,42Y78@68525|delta/epsilon subdivisions,2X3CW@28221|Deltaproteobacteria,2YUS0@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2891)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2891
k59_1488973_1	998674.ATTE01000001_gene2757	2.19e-33	131.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,45ZYF@72273|Thiotrichales	72273|Thiotrichales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_1191380_1	338963.Pcar_2879	2.52e-44	161.0	COG1251@1|root,COG2146@1|root,COG1251@2|Bacteria,COG2146@2|Bacteria,1MW58@1224|Proteobacteria,42PSQ@68525|delta/epsilon subdivisions,2WKDY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Pyr_redox_2
k59_134653_1	1193181.BN10_560059	3.61e-128	371.0	COG0462@1|root,COG0462@2|Bacteria,2GKR2@201174|Actinobacteria,4FFIH@85021|Intrasporangiaceae	201174|Actinobacteria	EF	Ribose-phosphate pyrophosphokinase	prs_1	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_134653_2	1240349.ANGC01000050_gene3974	5.67e-13	66.2	2E6D0@1|root,3310N@2|Bacteria,2GQP8@201174|Actinobacteria,4G34N@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3054)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3054
k59_82742_1	1121403.AUCV01000001_gene703	2.2e-66	214.0	COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,42MJ3@68525|delta/epsilon subdivisions,2WKD5@28221|Deltaproteobacteria,2MHQC@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_261410_1	396588.Tgr7_0285	1.3e-61	201.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,1WXN7@135613|Chromatiales	135613|Chromatiales	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_1191980_1	420662.Mpe_A0916	2.12e-21	92.0	COG0664@1|root,COG0664@2|Bacteria,1N3F0@1224|Proteobacteria,2VVAQ@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_135204_1	765912.Thimo_2546	1.84e-118	352.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1WW1H@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1719262_1	335543.Sfum_3755	1.5e-93	290.0	COG5421@1|root,COG5421@2|Bacteria,1Q09R@1224|Proteobacteria,437PJ@68525|delta/epsilon subdivisions,2WYMZ@28221|Deltaproteobacteria,2MRCG@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1844694_1	1123020.AUIE01000027_gene4559	2.9e-39	144.0	COG2199@1|root,COG3706@2|Bacteria,1RDWG@1224|Proteobacteria,1S7W2@1236|Gammaproteobacteria,1YEDJ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_777602_1	1108045.GORHZ_135_00250	3.89e-10	59.7	COG2267@1|root,COG2267@2|Bacteria,2GJUE@201174|Actinobacteria,4GF8B@85026|Gordoniaceae	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
k59_722059_1	288000.BBta_6442	2.64e-26	108.0	COG5621@1|root,COG5621@2|Bacteria,1QPJ4@1224|Proteobacteria,2TVNN@28211|Alphaproteobacteria,3JVX4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	hydroxyneurosporene synthase	crtC	GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016122,GO:0016123,GO:0016829,GO:0016835,GO:0016836,GO:0018904,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046148,GO:0071704,GO:1901178,GO:1901180,GO:1901503,GO:1901576	4.2.1.131	ko:K09844	ko00906,ko01100,map00906,map01100	-	R07516,R07519,R07522,R07528,R07532,R07536,R07539,R07543,R09790	RC00966	ko00000,ko00001,ko01000	-	-	-	-
k59_1777787_1	631362.Thi970DRAFT_04466	3.3e-82	257.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1WW6N@135613|Chromatiales	135613|Chromatiales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_27522_1	765912.Thimo_1302	1.21e-27	109.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1WWFA@135613|Chromatiales	135613|Chromatiales	E	PFAM Prephenate dehydratase	-	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
k59_27522_2	768671.ThimaDRAFT_0249	1.61e-59	194.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,1WWZH@135613|Chromatiales	135613|Chromatiales	EH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_964365_1	1380394.JADL01000002_gene1251	7.67e-58	189.0	COG3734@1|root,COG3734@2|Bacteria,1MWGX@1224|Proteobacteria,2TTG8@28211|Alphaproteobacteria,2JSCZ@204441|Rhodospirillales	204441|Rhodospirillales	G	2-keto-3-deoxy-galactonokinase	dgoK	-	2.7.1.58	ko:K00883	ko00052,ko01100,map00052,map01100	M00552	R03387	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	DGOK
k59_905361_1	304371.MCP_1342	1.36e-44	159.0	COG2202@1|root,arCOG06712@1|root,arCOG06515@2157|Archaea,arCOG06712@2157|Archaea,2Y7SX@28890|Euryarchaeota,2NBM4@224756|Methanomicrobia	224756|Methanomicrobia	T	Contains one ATP-binding region, ATPase-like domain (IPR003594)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_377132_1	553385.JEMF01000015_gene315	9.56e-10	58.9	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,1XI7M@135619|Oceanospirillales	135619|Oceanospirillales	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_83555_1	926569.ANT_14470	5.84e-59	206.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,2G5NF@200795|Chloroflexi	200795|Chloroflexi	C	COGs COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	xdh	-	-	ko:K12528	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_1080884_1	1163617.SCD_n02041	2.28e-132	389.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2VI6V@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
k59_604004_1	1304885.AUEY01000030_gene2429	1.77e-114	343.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,42M90@68525|delta/epsilon subdivisions,2WJ9G@28221|Deltaproteobacteria,2MHV2@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_135247_1	1385520.N802_10710	8.24e-06	50.1	COG4315@1|root,COG4315@2|Bacteria,2GNDV@201174|Actinobacteria,4FHB7@85021|Intrasporangiaceae	201174|Actinobacteria	S	Secreted repeat of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
k59_964388_1	367299.JOEE01000005_gene3636	1.66e-105	310.0	COG1718@1|root,COG1718@2|Bacteria,2GKX1@201174|Actinobacteria,4FEY6@85021|Intrasporangiaceae	201174|Actinobacteria	DT	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1543324_1	134676.ACPL_6355	1.44e-25	103.0	COG1189@1|root,COG1189@2|Bacteria,2GJVT@201174|Actinobacteria,4DAFA@85008|Micromonosporales	201174|Actinobacteria	J	FtsJ-like methyltransferase	tlyA	GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
k59_1254937_1	502025.Hoch_3531	2.16e-64	221.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIWK@28221|Deltaproteobacteria,2YU9H@29|Myxococcales	28221|Deltaproteobacteria	CP	Domain of unknown function (DUF4040)	mrpA	-	-	ko:K05559,ko:K05565	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
k59_1316571_1	471853.Bcav_1939	4.95e-36	126.0	COG1200@1|root,COG1200@2|Bacteria,2IHRX@201174|Actinobacteria	201174|Actinobacteria	KL	Nucleic acid binding, OB-fold, tRNA	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1316571_2	1380354.JIAN01000006_gene682	2.59e-89	271.0	28J4D@1|root,30NZ9@2|Bacteria,2I2E9@201174|Actinobacteria,4F14W@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3710)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3710
k59_261488_1	1323663.AROI01000006_gene2835	2.9e-107	321.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	iSFV_1184.SFV_2953	GCV_T,GCV_T_C
k59_27562_1	479435.Kfla_2734	3.67e-21	103.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4DP00@85009|Propionibacteriales	201174|Actinobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Laminin_G_3,Malectin,PKD
k59_1316573_1	1123368.AUIS01000031_gene1422	5.37e-53	178.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,1RQNF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_969979_1	452637.Oter_0894	9.76e-93	303.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,46U9T@74201|Verrucomicrobia,3K7GP@414999|Opitutae	414999|Opitutae	E	glutamate synthase	-	-	1.4.7.1	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	-	R00021,R10086	RC00006,RC00010	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_267885_1	1380390.JIAT01000011_gene2565	9.73e-61	210.0	COG0085@1|root,COG0085@2|Bacteria,2GJ81@201174|Actinobacteria,4CPMH@84995|Rubrobacteria	84995|Rubrobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_89140_1	977880.RALTA_A2590	2.01e-75	244.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,1K02J@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_969983_1	767817.Desgi_1423	2.94e-47	166.0	COG0006@1|root,COG0006@2|Bacteria,1TSXE@1239|Firmicutes,248AF@186801|Clostridia,2604W@186807|Peptococcaceae	186801|Clostridia	E	PFAM peptidase M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
k59_607967_1	439235.Dalk_1642	4.17e-50	177.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2MIW3@213118|Desulfobacterales	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB-2	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_1850427_3	1032480.MLP_41730	3.62e-05	47.8	COG0322@1|root,COG2176@1|root,COG0322@2|Bacteria,COG2176@2|Bacteria,2GMC0@201174|Actinobacteria,4DNVQ@85009|Propionibacteriales	201174|Actinobacteria	L	DNA polymerase III, epsilon subunit	dnaQ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,UVR
k59_725698_1	338966.Ppro_1754	0.000291	43.5	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42MSQ@68525|delta/epsilon subdivisions,2WISJ@28221|Deltaproteobacteria,43UEN@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK-1	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
k59_725698_2	1408473.JHXO01000004_gene259	3.73e-31	115.0	COG4747@1|root,COG4747@2|Bacteria,4NQIW@976|Bacteroidetes,2FS2U@200643|Bacteroidia	976|Bacteroidetes	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
k59_1665892_1	1116375.VEJY3_08030	2.97e-46	155.0	COG3063@1|root,COG3063@2|Bacteria,1RD9T@1224|Proteobacteria,1S3R3@1236|Gammaproteobacteria,1XX1A@135623|Vibrionales	135623|Vibrionales	NU	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_8
k59_1665892_2	1537994.JQFW01000057_gene282	1.32e-52	177.0	28KE4@1|root,2ZA0D@2|Bacteria,1MXZT@1224|Proteobacteria,1RYV4@1236|Gammaproteobacteria,4695I@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1547057_1	1267535.KB906767_gene3709	0.000737	43.5	COG1538@1|root,COG1538@2|Bacteria,3Y73J@57723|Acidobacteria,2JM9N@204432|Acidobacteriia	204432|Acidobacteriia	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1547057_2	990285.RGCCGE502_03017	6.48e-13	67.4	2ESJH@1|root,33K45@2|Bacteria,1PXP4@1224|Proteobacteria,2V0GG@28211|Alphaproteobacteria,4BGM9@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
k59_667253_1	1123296.JQKE01000025_gene1280	6.85e-89	275.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,2KQHP@206351|Neisseriales	206351|Neisseriales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
k59_1085735_1	1499967.BAYZ01000097_gene4378	6.94e-08	56.2	COG4974@1|root,COG4974@2|Bacteria,2NP4H@2323|unclassified Bacteria	2|Bacteria	L	Phage integrase, N-terminal SAM-like domain	xerC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_911018_1	1123257.AUFV01000006_gene395	6.05e-47	160.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1X4Q1@135614|Xanthomonadales	135614|Xanthomonadales	C	cytochrome	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
k59_382748_2	1206732.BAGD01000072_gene2863	7.25e-05	47.8	COG3391@1|root,COG3391@2|Bacteria,2HFN9@201174|Actinobacteria,4G41U@85025|Nocardiaceae	201174|Actinobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_35328_1	225849.swp_4835	1.82e-11	65.9	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,1RQWB@1236|Gammaproteobacteria,2QA1Q@267890|Shewanellaceae	1236|Gammaproteobacteria	O	PFAM cytochrome oxidase assembly	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
k59_35328_2	857087.Metme_4126	4.42e-118	347.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,1XDMX@135618|Methylococcales	135618|Methylococcales	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	cyoE	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_1323080_1	1380391.JIAS01000011_gene5146	8.61e-44	158.0	COG0402@1|root,COG0402@2|Bacteria,1MUFE@1224|Proteobacteria,2TR3A@28211|Alphaproteobacteria,2JPEJ@204441|Rhodospirillales	204441|Rhodospirillales	F	Amidohydrolase family	-	-	3.5.3.13	ko:K05603	ko00340,map00340	-	R02286	RC00682	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_843723_1	472759.Nhal_2538	6.29e-93	301.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales	135613|Chromatiales	E	Vitamin B12 dependent methionine synthase activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_432423_1	314278.NB231_01329	2.19e-09	58.5	COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,1RQIE@1236|Gammaproteobacteria,1X2GE@135613|Chromatiales	135613|Chromatiales	M	Belongs to the skp family	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
k59_432423_2	631362.Thi970DRAFT_03553	1.05e-164	490.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1WXD9@135613|Chromatiales	135613|Chromatiales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_1723783_2	1284679.HMPREF1626_09560	3.21e-100	298.0	COG2197@1|root,COG2197@2|Bacteria,2GIVA@201174|Actinobacteria,4D3HG@85005|Actinomycetales	201174|Actinobacteria	K	regulator	tcsR3	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_90063_1	1163745.HCD_07905	5.2e-08	60.1	COG0697@1|root,COG0697@2|Bacteria,1RCED@1224|Proteobacteria,42QVG@68525|delta/epsilon subdivisions	1224|Proteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_667794_1	1410634.JHVD01000002_gene223	5.92e-19	88.6	COG2027@1|root,COG2027@2|Bacteria,2GJPH@201174|Actinobacteria,4DN2Y@85009|Propionibacteriales	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	dacB	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
k59_1323094_1	981383.AEWH01000004_gene3339	1.78e-31	123.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,4H9VE@91061|Bacilli	91061|Bacilli	S	Belongs to the binding-protein-dependent transport system permease family	yufP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_1371635_1	404589.Anae109_3234	2.54e-38	140.0	COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,42PD2@68525|delta/epsilon subdivisions,2WJIK@28221|Deltaproteobacteria,2Z26E@29|Myxococcales	28221|Deltaproteobacteria	C	Radical SAM superfamily	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SEC-C,SPASM
k59_1371635_2	1380354.JIAN01000005_gene2684	4.04e-35	125.0	2CXR2@1|root,32T2F@2|Bacteria,2I2M0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_35341_1	1218075.BAYA01000006_gene2462	1.53e-32	117.0	COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,2VR31@28216|Betaproteobacteria,1K3IP@119060|Burkholderiaceae	28216|Betaproteobacteria	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
k59_35341_2	1122604.JONR01000010_gene3835	1.78e-104	305.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,1X38F@135614|Xanthomonadales	135614|Xanthomonadales	E	Histidine biosynthesis bifunctional protein HisB	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15,4.2.1.19	ko:K01089	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013,R03457	RC00017,RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	Hydrolase_like,IGPD,PNK3P
k59_1431563_1	1265313.HRUBRA_00927	8.02e-69	217.0	COG0811@1|root,COG0811@2|Bacteria,1NXZ9@1224|Proteobacteria,1S154@1236|Gammaproteobacteria,1J4YC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	COG0811 Biopolymer transport proteins	-	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
k59_726251_2	1120983.KB894570_gene1549	2.55e-36	135.0	COG2985@1|root,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,2U1RU@28211|Alphaproteobacteria,1JPXY@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Predicted Permease Membrane Region	-	-	-	ko:K07085	-	-	-	-	ko00000	2.A.81	-	-	Asp-Al_Ex,TrkA_C
k59_383620_1	768671.ThimaDRAFT_3401	5.51e-133	389.0	2CB8R@1|root,2Z90U@2|Bacteria,1R4DV@1224|Proteobacteria,1RPSZ@1236|Gammaproteobacteria,1WZX3@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1782103_1	439235.Dalk_2373	4.03e-79	249.0	COG0426@1|root,COG0426@2|Bacteria,1R4UD@1224|Proteobacteria,43AF5@68525|delta/epsilon subdivisions,2X5UW@28221|Deltaproteobacteria,2MPG5@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Flavodoxin	roo	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B,Lactamase_B_2
k59_1016394_1	765912.Thimo_1199	4.46e-83	266.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1WVYF@135613|Chromatiales	135613|Chromatiales	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1666434_1	1158292.JPOE01000005_gene381	3.1e-40	144.0	COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,2VPAP@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
k59_667814_1	760192.Halhy_3081	6.59e-12	71.2	COG1033@1|root,COG1033@2|Bacteria,4NE0M@976|Bacteroidetes,1IQCU@117747|Sphingobacteriia	976|Bacteroidetes	S	of the RND superfamily	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_549839_2	1380347.JNII01000008_gene4380	1.06e-54	182.0	COG3745@1|root,COG3745@2|Bacteria,2INHS@201174|Actinobacteria	201174|Actinobacteria	U	Pilus assembly protein	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
k59_1605762_1	1278073.MYSTI_02085	1.06e-50	178.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,2YU81@29|Myxococcales	28221|Deltaproteobacteria	L	ABC transporter	snorO	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_1605762_2	73044.JNXP01000034_gene3903	2.23e-19	81.6	COG0346@1|root,COG0346@2|Bacteria,2IHYP@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_1782112_1	1232683.ADIMK_1509	1.71e-88	283.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,463XQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_1547580_3	1122194.AUHU01000006_gene485	1.45e-06	50.1	COG1360@1|root,COG1360@2|Bacteria,1QUFR@1224|Proteobacteria,1T1XE@1236|Gammaproteobacteria,463XV@72275|Alteromonadaceae	1236|Gammaproteobacteria	N	COG1360 Flagellar motor protein	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
k59_268988_1	1255043.TVNIR_2956	5.5e-34	128.0	COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,1RR11@1236|Gammaproteobacteria,1WW55@135613|Chromatiales	135613|Chromatiales	DM	peptidase	-	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	LysM,Peptidase_M23
k59_1495225_1	395493.BegalDRAFT_1783	1.89e-35	127.0	COG3198@1|root,COG3198@2|Bacteria,1N75J@1224|Proteobacteria,1SC87@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	ccoH	-	-	ko:K09926	-	-	-	-	ko00000	-	-	-	FixH
k59_383647_1	568706.BN118_3392	5.03e-10	60.1	COG1813@1|root,COG1813@2|Bacteria,1QW09@1224|Proteobacteria,2WA4Y@28216|Betaproteobacteria,3T874@506|Alcaligenaceae	28216|Betaproteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
k59_90118_1	644282.Deba_1839	7.27e-89	273.0	28J6X@1|root,2Z92E@2|Bacteria,1R426@1224|Proteobacteria,42NPX@68525|delta/epsilon subdivisions,2WMA7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_90118_2	335543.Sfum_3780	6.56e-39	140.0	2CDJ3@1|root,2Z7R6@2|Bacteria,1PZM0@1224|Proteobacteria,42P6U@68525|delta/epsilon subdivisions,2WMMY@28221|Deltaproteobacteria,2MR8Z@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_549849_1	1283284.AZUK01000001_gene812	2.58e-61	194.0	COG2249@1|root,COG2249@2|Bacteria,1MUHN@1224|Proteobacteria,1RU3S@1236|Gammaproteobacteria,1Y501@135624|Aeromonadales	135624|Aeromonadales	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_2
k59_1196565_1	880072.Desac_0487	2.43e-42	142.0	2DWSR@1|root,341Q6@2|Bacteria,1Q538@1224|Proteobacteria,430G3@68525|delta/epsilon subdivisions,2WVK2@28221|Deltaproteobacteria,2MRYW@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1196565_2	290318.Cvib_1463	1.09e-11	65.1	COG0546@1|root,COG0546@2|Bacteria,1FDVN@1090|Chlorobi	1090|Chlorobi	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_35421_1	1089546.AQUI01000002_gene623	5.8e-45	171.0	COG2966@1|root,COG3610@1|root,COG2966@2|Bacteria,COG3610@2|Bacteria,2GJMC@201174|Actinobacteria,407NE@622450|Actinopolysporales	201174|Actinobacteria	S	Threonine/Serine exporter, ThrE	thrE	-	-	-	-	-	-	-	-	-	-	-	ThrE,ThrE_2
k59_608536_1	1231185.BAMP01000013_gene1965	2.94e-16	83.2	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,43GYR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1495242_1	1254432.SCE1572_30505	7.63e-50	168.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,42PQH@68525|delta/epsilon subdivisions,2WM5W@28221|Deltaproteobacteria,2Z39N@29|Myxococcales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
k59_35435_1	1304275.C41B8_14930	2.42e-57	198.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K13614	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NAD_binding_4,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
k59_911954_1	363253.LI0190	1.97e-46	160.0	COG1624@1|root,COG1624@2|Bacteria,1PEQT@1224|Proteobacteria,42P5A@68525|delta/epsilon subdivisions,2WKPP@28221|Deltaproteobacteria,2M84W@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
k59_1260806_1	323261.Noc_2672	1.34e-55	194.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,1WWQ3@135613|Chromatiales	135613|Chromatiales	S	DNA internalization-related competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_1547597_1	471853.Bcav_1337	6.17e-168	489.0	COG0296@1|root,COG0366@1|root,COG0296@2|Bacteria,COG0366@2|Bacteria,2GJKR@201174|Actinobacteria	201174|Actinobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_608546_1	1207075.PputUW4_03133	1.61e-52	175.0	COG1814@1|root,COG1814@2|Bacteria,1R469@1224|Proteobacteria	1224|Proteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
k59_667844_2	425104.Ssed_1829	1.38e-43	146.0	COG2905@1|root,COG2905@2|Bacteria,1MZGY@1224|Proteobacteria,1S86K@1236|Gammaproteobacteria,2QBX4@267890|Shewanellaceae	1236|Gammaproteobacteria	T	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_1605785_1	545276.KB898724_gene1817	1.99e-97	306.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1371680_1	935839.JAGJ01000004_gene1923	6.93e-80	249.0	COG2138@1|root,COG2138@2|Bacteria,2GNJ0@201174|Actinobacteria,4F53D@85017|Promicromonosporaceae	201174|Actinobacteria	S	CbiX	sirB	-	-	-	-	-	-	-	-	-	-	-	CbiX
k59_269041_1	367299.JOEE01000001_gene2100	8.33e-132	393.0	COG4867@1|root,COG4867@2|Bacteria,2H14W@201174|Actinobacteria,4FFT6@85021|Intrasporangiaceae	201174|Actinobacteria	S	von Willebrand factor (vWF) type A domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_1134788_1	631362.Thi970DRAFT_04294	1.92e-08	53.1	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,1S61C@1236|Gammaproteobacteria,1WY06@135613|Chromatiales	135613|Chromatiales	I	Cyclase dehydrase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
k59_1134788_2	754476.Q7A_2179	3.96e-31	113.0	COG2914@1|root,COG2914@2|Bacteria,1MZCH@1224|Proteobacteria,1SCHG@1236|Gammaproteobacteria,4614M@72273|Thiotrichales	72273|Thiotrichales	S	Belongs to the UPF0125 (RnfH) family	-	-	-	ko:K09801	-	-	-	-	ko00000	-	-	-	Ub-RnfH
k59_35469_1	585531.HMPREF0063_11978	5.6e-62	206.0	COG5438@1|root,COG5438@2|Bacteria,2GKJ4@201174|Actinobacteria,4DQ4D@85009|Propionibacteriales	201174|Actinobacteria	S	YibE/F-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YibE_F
k59_1323208_1	1122194.AUHU01000003_gene2080	5.59e-47	167.0	COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,1RR99@1236|Gammaproteobacteria,464X5@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
k59_549876_1	1121405.dsmv_1256	9.52e-16	76.3	COG2197@1|root,COG2197@2|Bacteria,1R3YQ@1224|Proteobacteria,42N0Q@68525|delta/epsilon subdivisions,2WM6W@28221|Deltaproteobacteria,2MIJG@213118|Desulfobacterales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,PAS_4,PAS_9
k59_549876_2	1121015.N789_06040	5.28e-25	102.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RM88@1236|Gammaproteobacteria,1X4PF@135614|Xanthomonadales	135614|Xanthomonadales	I	fatty acid desaturase	desC	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
k59_1851474_1	1267005.KB911265_gene3629	3.09e-34	127.0	2AFUA@1|root,315WQ@2|Bacteria,1NHGB@1224|Proteobacteria,2TQWW@28211|Alphaproteobacteria,3N79W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Putative transmembrane protein (Alph_Pro_TM)	MA20_19830	-	-	-	-	-	-	-	-	-	-	-	Alph_Pro_TM
k59_1547611_1	1207063.P24_05682	2.39e-22	91.7	COG3824@1|root,COG3824@2|Bacteria,1N18M@1224|Proteobacteria,2UBUK@28211|Alphaproteobacteria,2JSPD@204441|Rhodospirillales	204441|Rhodospirillales	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
k59_1782144_1	272134.KB731324_gene6531	5.1e-43	153.0	COG4586@1|root,COG4586@2|Bacteria,1G012@1117|Cyanobacteria,1H7SP@1150|Oscillatoriales	1117|Cyanobacteria	S	transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_198208_1	367299.JOEE01000007_gene218	6.3e-60	198.0	COG3583@1|root,COG3583@2|Bacteria,2H4RU@201174|Actinobacteria,4FF9G@85021|Intrasporangiaceae	201174|Actinobacteria	S	G5	rlpA	-	-	ko:K21688	-	-	-	-	ko00000	-	-	-	DUF348,G5,Transglycosylas
k59_1431633_1	1267005.KB911257_gene923	8.46e-84	268.0	COG5360@1|root,COG5360@2|Bacteria,1MUJ4@1224|Proteobacteria,2TR5G@28211|Alphaproteobacteria,3N6YX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Heparinase II/III-like protein	MA20_25080	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III
k59_90203_1	1279038.KB907343_gene2410	1.01e-33	133.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,2JPV0@204441|Rhodospirillales	204441|Rhodospirillales	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_1020585_2	1121015.N789_13500	1.44e-23	101.0	COG1461@1|root,COG1461@2|Bacteria,1NKAM@1224|Proteobacteria,1SHAC@1236|Gammaproteobacteria,1X3IB@135614|Xanthomonadales	135614|Xanthomonadales	S	Dak2	-	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak2,DegV
k59_203145_2	1336245.JAGO01000013_gene1462	2.1e-27	107.0	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,1S3UD@1236|Gammaproteobacteria,1XJQG@135619|Oceanospirillales	135619|Oceanospirillales	E	D,D-heptose 1,7-bisphosphate phosphatase	gmhB	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
k59_1436630_1	1123269.NX02_10215	2.36e-51	176.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2TT2F@28211|Alphaproteobacteria,2K0I7@204457|Sphingomonadales	204457|Sphingomonadales	C	NADH flavin	-	-	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
k59_1332417_1	2074.JNYD01000005_gene3238	2.4e-63	214.0	COG1524@1|root,COG1524@2|Bacteria,2HH0Q@201174|Actinobacteria	201174|Actinobacteria	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_4_2,Phosphodiest
k59_392760_1	237368.SCABRO_03229	4.1e-33	131.0	COG3291@1|root,COG4733@1|root,COG3291@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,Laminin_G_3,PKD,PPC,Phage-tail_3,Reprolysin_3,fn3
k59_1332419_1	1397527.Q670_09235	2.55e-09	57.4	COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,1S1Y6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
k59_1332419_2	1121035.AUCH01000006_gene715	3.17e-66	210.0	COG0847@1|root,COG0847@2|Bacteria,1RAF1@1224|Proteobacteria,2WC0K@28216|Betaproteobacteria,2KZAH@206389|Rhodocyclales	206389|Rhodocyclales	L	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases	-	-	-	-	-	-	-	-	-	-	-	-	RNase_T
k59_1376492_1	1304865.JAGF01000001_gene2873	1.02e-64	209.0	COG0613@1|root,COG0613@2|Bacteria,2GIZ5@201174|Actinobacteria,4F0I0@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3097)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3097
k59_275438_1	105559.Nwat_0477	2.82e-38	129.0	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,1S8UG@1236|Gammaproteobacteria,1WYZ3@135613|Chromatiales	135613|Chromatiales	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
k59_275438_2	1177181.T9A_02366	3.54e-21	84.0	COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,1SCEJ@1236|Gammaproteobacteria,1XMCR@135619|Oceanospirillales	135619|Oceanospirillales	J	there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
k59_275438_3	105559.Nwat_0313	7.14e-07	50.4	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RSN1@1236|Gammaproteobacteria,1WVUQ@135613|Chromatiales	135613|Chromatiales	I	PFAM Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	DDE_Tnp_ISL3,FA_desaturase
k59_785743_1	1380391.JIAS01000011_gene4870	1.51e-39	142.0	COG3491@1|root,COG3491@2|Bacteria,1R7CS@1224|Proteobacteria,2TUIU@28211|Alphaproteobacteria,2JYH2@204441|Rhodospirillales	204441|Rhodospirillales	C	non-haem dioxygenase in morphine synthesis N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy,DIOX_N
k59_785743_2	1082932.ATCR1_12428	6.07e-06	47.0	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TT05@28211|Alphaproteobacteria,4BDF0@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	flavoprotein involved in K transport	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	FMO-like,NAD_binding_8,Pyr_redox_3,SnoaL_2
k59_1092159_1	580332.Slit_1715	7.77e-116	348.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2VHJ5@28216|Betaproteobacteria,44WIW@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Fumarate reductase flavoprotein C-term	-	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_99291_1	1386089.N865_18585	5.02e-39	139.0	COG0671@1|root,COG0671@2|Bacteria,2IAUJ@201174|Actinobacteria,4FF1D@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	DUF2189,PAP2
k59_99291_2	367299.JOEE01000002_gene2432	6.35e-08	53.9	COG0671@1|root,COG0671@2|Bacteria,2I9FB@201174|Actinobacteria,4FEH1@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
k59_144620_1	1049564.TevJSym_ar00090	6.29e-104	311.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1J5D5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1552452_1	314278.NB231_05831	2.03e-68	214.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,1WY2J@135613|Chromatiales	135613|Chromatiales	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_1552452_2	2340.JV46_22770	1.2e-96	297.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1J5GF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	COG1530 Ribonucleases G and E	rng	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_42307_1	768671.ThimaDRAFT_0847	3.06e-66	220.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1SA31@1236|Gammaproteobacteria	1224|Proteobacteria	T	SMART ATP-binding region, ATPase-like	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3
k59_1552461_1	1128421.JAGA01000002_gene785	4.63e-97	299.0	COG1003@1|root,COG1003@2|Bacteria,2NNSG@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS11880	Aminotran_5,GDC-P
k59_1500767_1	634956.Geoth_0441	1.95e-05	52.8	COG2390@1|root,COG2390@2|Bacteria,1TP62@1239|Firmicutes,4HAE6@91061|Bacilli,1WE56@129337|Geobacillus	91061|Bacilli	K	Putative sugar-binding domain	cggR	-	-	ko:K05311	-	-	-	-	ko00000,ko03000	-	-	-	Sugar-bind
k59_42328_1	713587.THITH_04050	2.43e-110	334.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1WW79@135613|Chromatiales	135613|Chromatiales	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
k59_848783_1	717785.HYPMC_4599	1.9e-42	142.0	COG2142@1|root,COG2142@2|Bacteria,1MZND@1224|Proteobacteria,2UC3G@28211|Alphaproteobacteria,3N77Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	sdhD	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_848783_2	582899.Hden_3240	6.9e-37	127.0	COG2009@1|root,COG2009@2|Bacteria,1N02N@1224|Proteobacteria,2UC47@28211|Alphaproteobacteria,3N7AM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	succinate dehydrogenase	sdhC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_921195_1	1190603.AJYD01000005_gene3913	1.73e-36	132.0	COG0483@1|root,COG0483@2|Bacteria,1NFR1@1224|Proteobacteria,1S31N@1236|Gammaproteobacteria,1Y0NG@135623|Vibrionales	135623|Vibrionales	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_980310_1	1121035.AUCH01000016_gene2122	4.32e-45	151.0	COG1522@1|root,COG1522@2|Bacteria,1RIKY@1224|Proteobacteria,2VSBM@28216|Betaproteobacteria,2KWF6@206389|Rhodocyclales	206389|Rhodocyclales	K	overlaps another CDS with the same product name	nirG	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
k59_613641_1	1499967.BAYZ01000139_gene171	2.97e-17	82.8	COG2114@1|root,COG2114@2|Bacteria,2NP16@2323|unclassified Bacteria	2|Bacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_731484_1	991905.SL003B_0568	1.79e-112	339.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2TVHI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome D1 heme domain	nirN	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_144650_1	95619.PM1_0208040	4.58e-12	65.1	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfD	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0044464,GO:0055114,GO:0071944	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
k59_144650_2	1249627.D779_2319	9.04e-87	261.0	COG4659@1|root,COG4659@2|Bacteria,1RDEP@1224|Proteobacteria,1RPAD@1236|Gammaproteobacteria,1WVYN@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
k59_392841_1	472759.Nhal_1481	1.12e-22	96.3	COG2403@1|root,COG2403@2|Bacteria,1MV4C@1224|Proteobacteria	1224|Proteobacteria	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1786443_1	580332.Slit_0288	1.68e-22	94.4	2AJXH@1|root,31AKJ@2|Bacteria,1RJPF@1224|Proteobacteria,2VTF5@28216|Betaproteobacteria,44W13@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Domain of unknown function (DUF4149)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4149
k59_1786443_2	519989.ECTPHS_06997	4.41e-68	210.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,1WY5U@135613|Chromatiales	135613|Chromatiales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_1786443_3	1260251.SPISAL_03055	1.02e-76	255.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1WVW8@135613|Chromatiales	135613|Chromatiales	EF	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_496371_1	1128421.JAGA01000002_gene1295	7.1e-61	199.0	COG0559@1|root,COG0559@2|Bacteria,2NP7Z@2323|unclassified Bacteria	2|Bacteria	E	Branched-chain amino acid transport system / permease component	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_921213_1	1255043.TVNIR_1548	4.13e-150	434.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1WXP7@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_1092201_1	765913.ThidrDRAFT_1366	7.35e-57	184.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria,1WY7U@135613|Chromatiales	135613|Chromatiales	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
k59_731487_1	1121878.AUGL01000010_gene1079	4.37e-104	313.0	COG0786@1|root,COG0786@2|Bacteria,1MVBC@1224|Proteobacteria,1RP0S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Catalyzes the sodium-dependent transport of glutamate	gltS	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
k59_1671582_1	314278.NB231_11974	9.62e-46	154.0	COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,1WWW9@135613|Chromatiales	135613|Chromatiales	L	Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis	rnt	-	-	ko:K03683	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_T
k59_1671582_2	697282.Mettu_2882	3.89e-26	98.2	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,1XFF2@135618|Methylococcales	135618|Methylococcales	C	Belongs to the glutaredoxin family. Monothiol subfamily	-	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
k59_980343_1	228410.NE1204	4.34e-76	244.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2VKEE@28216|Betaproteobacteria,371XI@32003|Nitrosomonadales	28216|Betaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1201600_1	358823.DF19_31700	3.54e-88	278.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria	201174|Actinobacteria	G	alpha amylase, catalytic	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_1266389_1	216596.RL3998	1e-116	347.0	COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,2TT6S@28211|Alphaproteobacteria,4B8FR@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	6-phosphogluconate dehydrogenase	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
k59_1436691_1	870187.Thini_0399	1.23e-22	96.3	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,1RMNR@1236|Gammaproteobacteria,4609K@72273|Thiotrichales	72273|Thiotrichales	E	Aminotransferase class-V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_437657_1	1429046.RR21198_1694	7.12e-105	323.0	COG1680@1|root,COG1680@2|Bacteria,2GN1H@201174|Actinobacteria,4G8ND@85025|Nocardiaceae	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_144666_1	335543.Sfum_1219	4.09e-121	355.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2WJ4D@28221|Deltaproteobacteria,2MQW6@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	yfdZ	-	2.6.1.83	ko:K10206,ko:K14261	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1266399_1	1454004.AW11_00592	1.41e-76	239.0	COG1226@1|root,2Z7ZD@2|Bacteria,1MXKM@1224|Proteobacteria,2VZJ4@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Polycystin cation channel	-	-	-	ko:K08714	-	-	-	-	ko00000,ko02000	1.A.1.14	-	-	Ion_trans
k59_99392_1	426117.M446_1580	1.66e-64	212.0	COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,2TYKE@28211|Alphaproteobacteria,1JZI1@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1436704_1	1255043.TVNIR_1180	9.42e-97	295.0	COG0446@1|root,COG0446@2|Bacteria,1QA17@1224|Proteobacteria,1RSA6@1236|Gammaproteobacteria,1WXMR@135613|Chromatiales	135613|Chromatiales	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_99401_1	1146883.BLASA_2719	5.28e-96	307.0	COG1061@1|root,COG4951@1|root,COG1061@2|Bacteria,COG4951@2|Bacteria,2GIR9@201174|Actinobacteria	201174|Actinobacteria	L	helicase	-	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	Glyoxalase,Helicase_C,Lsr2,ResIII
k59_1500833_1	382464.ABSI01000006_gene815	8.32e-34	137.0	COG0771@1|root,COG2911@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,46UDY@74201|Verrucomicrobia,2IWGN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	Q	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_99404_2	1122212.AULO01000006_gene1853	7.27e-19	87.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1XI7V@135619|Oceanospirillales	135619|Oceanospirillales	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	ppnK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_1266424_1	172088.AUGA01000036_gene3199	1.35e-96	290.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2TU3A@28211|Alphaproteobacteria,3JW29@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	MA20_06335	-	4.2.1.156,4.2.1.42,5.1.2.2	ko:K01781,ko:K20023	ko00053,ko00627,ko01120,map00053,map00627,map01120	-	R03791,R04161,R05608	RC00543,RC00998	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_203943_1	754476.Q7A_999	8.65e-35	135.0	COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,460M8@72273|Thiotrichales	72273|Thiotrichales	M	LppC putative lipoprotein	-	-	-	ko:K07121	-	-	-	-	ko00000	-	-	-	LppC
k59_732191_1	1385519.N801_10195	1.17e-34	132.0	COG0433@1|root,COG0433@2|Bacteria,2IQZ3@201174|Actinobacteria	201174|Actinobacteria	T	COG0433 Predicted ATPase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_100485_1	367299.JOEE01000008_gene427	1.36e-137	405.0	COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria,4FEE6@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_1611321_1	768671.ThimaDRAFT_4890	2.08e-44	156.0	COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,1RQ7I@1236|Gammaproteobacteria,1WWFP@135613|Chromatiales	135613|Chromatiales	L	PFAM integrase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve
k59_1611321_2	243159.AFE_2393	3.17e-13	67.8	COG3415@1|root,COG3415@2|Bacteria,1RFNA@1224|Proteobacteria,1S5WD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2963 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_Tnp_1
k59_276652_1	187272.Mlg_1865	7.15e-128	392.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales	135613|Chromatiales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2
k59_276656_1	1517681.HW45_20225	6.28e-08	57.0	COG0596@1|root,COG0596@2|Bacteria,1QTTN@1224|Proteobacteria,1RZJX@1236|Gammaproteobacteria,1Y2F9@135623|Vibrionales	135623|Vibrionales	S	Ndr family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_276656_2	1454004.AW11_02394	3.58e-39	143.0	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VHA3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Phospholipase, patatin family	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_981511_1	292415.Tbd_0367	2.86e-97	313.0	COG1392@1|root,COG1392@2|Bacteria,1MW5V@1224|Proteobacteria,2VM9A@28216|Betaproteobacteria,1KRYF@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Phosphate transport regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_981511_2	36809.MAB_1845c	5.66e-12	65.9	28QKY@1|root,2ZD2Q@2|Bacteria,2IM53@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_276667_1	1249627.D779_0846	1.46e-156	451.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1WWHU@135613|Chromatiales	135613|Chromatiales	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_276667_2	713586.KB900536_gene1829	3.14e-05	47.0	COG1418@1|root,COG1418@2|Bacteria,1MZUS@1224|Proteobacteria,1S5FK@1236|Gammaproteobacteria,1WYFS@135613|Chromatiales	135613|Chromatiales	S	mRNA catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_43561_1	765913.ThidrDRAFT_1080	2.32e-91	292.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1WW5E@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1333704_1	998674.ATTE01000001_gene499	3.2e-45	160.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,46093@72273|Thiotrichales	72273|Thiotrichales	LU	TIGRFAM DNA protecting protein DprA	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_1333704_2	1283300.ATXB01000001_gene1100	2.1e-34	128.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1XE9I@135618|Methylococcales	135618|Methylococcales	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_1862014_1	1379281.AVAG01000082_gene1847	6.87e-41	145.0	COG0730@1|root,COG0730@2|Bacteria,1N1I6@1224|Proteobacteria,42N92@68525|delta/epsilon subdivisions,2WJT2@28221|Deltaproteobacteria,2M9Y1@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_1862014_2	596151.DesfrDRAFT_0495	3.2e-24	99.0	2CM4C@1|root,32SDN@2|Bacteria,1NAW5@1224|Proteobacteria,42W10@68525|delta/epsilon subdivisions,2WSB0@28221|Deltaproteobacteria,2MCN7@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_922439_1	519989.ECTPHS_03879	1.72e-84	259.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1WVY1@135613|Chromatiales	135613|Chromatiales	HJ	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
k59_922439_2	314278.NB231_13326	6.57e-62	192.0	COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S4CZ@1236|Gammaproteobacteria,1WY6S@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_276671_1	1043493.BBLU01000001_gene718	1e-129	376.0	COG1622@1|root,COG1622@2|Bacteria,2GNXA@201174|Actinobacteria	201174|Actinobacteria	C	I and II form the functional core of the enzyme complex. electrons originating in cytochrome C are transferred via HemE a and cu(a) to the binuclear center formed by HemE A3 and cu(B)	ctaC	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
k59_276671_2	446469.Sked_15640	1.47e-151	442.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0040007,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_394022_1	2340.JV46_26380	2.47e-99	301.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,1J51D@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_100518_1	1238450.VIBNISOn1_1630010	7.52e-108	318.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,1RSNX@1236|Gammaproteobacteria,1XWDU@135623|Vibrionales	135623|Vibrionales	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve
k59_1501690_1	1049564.TevJSym_ae00700	1.28e-71	236.0	COG0664@1|root,COG1033@1|root,COG0664@2|Bacteria,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1J7PV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Sterol-sensing domain of SREBP cleavage-activation	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL,cNMP_binding
k59_438373_1	742766.HMPREF9455_00387	8.47e-15	72.0	COG3279@1|root,COG3279@2|Bacteria,4NGBF@976|Bacteroidetes,2FMKB@200643|Bacteroidia,22WPQ@171551|Porphyromonadaceae	976|Bacteroidetes	T	LytTr DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
k59_438373_2	742766.HMPREF9455_00386	1.19e-77	242.0	COG2972@1|root,COG2972@2|Bacteria,4NFDP@976|Bacteroidetes,2FPUC@200643|Bacteroidia,22WCU@171551|Porphyromonadaceae	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	His_kinase
k59_276678_1	1163617.SCD_n00367	7.3e-28	107.0	COG2863@1|root,COG2863@2|Bacteria,1R8K9@1224|Proteobacteria	1224|Proteobacteria	C	Pfam cytochrome c	-	-	-	ko:K17230	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_1093065_1	765911.Thivi_3112	4.05e-60	189.0	COG1150@1|root,COG1150@2|Bacteria,1R874@1224|Proteobacteria,1SHQ0@1236|Gammaproteobacteria,1WZZ0@135613|Chromatiales	135613|Chromatiales	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K16887	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_8
k59_1440892_1	188626.HMPREF0321_1983	9.56e-118	353.0	COG1457@1|root,COG1457@2|Bacteria,2GJ6B@201174|Actinobacteria,1ZVHU@145357|Dermacoccaceae	201174|Actinobacteria	F	Belongs to the purine-cytosine permease (2.A.39) family	-	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
k59_789295_2	1286106.MPL1_13038	1.22e-48	159.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,1RRP3@1236|Gammaproteobacteria,460FG@72273|Thiotrichales	72273|Thiotrichales	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_1505604_1	525146.Ddes_2292	6.14e-08	58.2	COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,42SBG@68525|delta/epsilon subdivisions,2WP66@28221|Deltaproteobacteria,2MB3T@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM AMMECR1 domain protein	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
k59_281291_1	177437.HRM2_33940	1.1e-65	220.0	COG5421@1|root,COG5421@2|Bacteria,1R25F@1224|Proteobacteria,433HE@68525|delta/epsilon subdivisions,2WYHG@28221|Deltaproteobacteria,2MP7M@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Domain of unknown function (DUF4277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4277
k59_1556713_1	479435.Kfla_5971	3.16e-18	86.3	COG0464@1|root,COG0464@2|Bacteria,2GJWA@201174|Actinobacteria,4DTIV@85009|Propionibacteriales	201174|Actinobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_987309_1	1249627.D779_0337	1.8e-09	57.4	COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,1SCBI@1236|Gammaproteobacteria,1WZ69@135613|Chromatiales	135613|Chromatiales	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	-	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
k59_1440906_1	1380394.JADL01000002_gene1454	7.97e-79	244.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TS33@28211|Alphaproteobacteria,2JQG3@204441|Rhodospirillales	204441|Rhodospirillales	E	Cysteine synthase	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_324805_1	2340.JV46_19120	5.36e-105	316.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1JBG6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cysteine-rich domain	dgcB	-	-	ko:K21834	-	-	-	-	ko00000	-	-	-	CCG,DUF3483,Fer4_8
k59_48504_2	644282.Deba_3157	3.8e-42	144.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,42V63@68525|delta/epsilon subdivisions,2WQCH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	TIGRFAM transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
k59_1205789_1	1397528.Q671_14960	1.34e-69	220.0	COG3677@1|root,COG3677@2|Bacteria,1NUTK@1224|Proteobacteria,1S11R@1236|Gammaproteobacteria,1XS39@135619|Oceanospirillales	135619|Oceanospirillales	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_1556727_1	1458357.BG58_17310	7.71e-28	114.0	COG2197@1|root,COG2267@1|root,COG2197@2|Bacteria,COG2267@2|Bacteria,1QYHB@1224|Proteobacteria,2W1S8@28216|Betaproteobacteria,1K5IY@119060|Burkholderiaceae	28216|Betaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,GerE
k59_789313_1	589865.DaAHT2_1626	2.09e-10	66.2	COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,1R4NG@1224|Proteobacteria	1224|Proteobacteria	T	periplasmic ligand-binding sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,GGDEF,PAS_4
k59_106324_1	1121933.AUHH01000059_gene167	1.22e-60	210.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4DN5X@85009|Propionibacteriales	201174|Actinobacteria	L	Bacterial DNA polymerase III alpha subunit	dnaE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_500646_1	1266998.ATUJ01000006_gene92	1.43e-88	275.0	COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,2TQVA@28211|Alphaproteobacteria,2PU9M@265|Paracoccus	28211|Alphaproteobacteria	E	Sodium:alanine symporter family	alsT	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_441953_1	471853.Bcav_2287	1.03e-151	461.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_677349_1	1225184.ALXE01000021_gene2600	2.34e-17	87.8	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,3VXPH@53335|Pantoea	1236|Gammaproteobacteria	S	With LptABCF is involved in the transport of lipopolysaccharides	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_106331_1	1255043.TVNIR_3268	2.21e-25	105.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RQ11@1236|Gammaproteobacteria,1WX9G@135613|Chromatiales	135613|Chromatiales	C	PFAM Malic enzyme, NAD binding domain	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
k59_400592_1	105559.Nwat_0045	1.16e-119	375.0	COG1474@1|root,COG1474@2|Bacteria,1R5I2@1224|Proteobacteria,1RXXF@1236|Gammaproteobacteria,1WVZI@135613|Chromatiales	135613|Chromatiales	LO	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_282039_1	391626.OAN307_c44780	1.16e-51	177.0	COG3488@1|root,COG3488@2|Bacteria,1MXUW@1224|Proteobacteria,2TS75@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Thiol oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DHOR
k59_282043_1	1122138.AQUZ01000039_gene8047	1.23e-61	201.0	COG4974@1|root,COG4974@2|Bacteria,2IGA2@201174|Actinobacteria,4DT9K@85009|Propionibacteriales	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1441374_1	1195246.AGRI_13535	4.7e-24	98.6	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,465FN@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_1441374_2	1049564.TevJSym_ac02030	6.32e-37	125.0	COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,1S8QZ@1236|Gammaproteobacteria,1J6RF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
k59_1143224_1	1278309.KB907101_gene379	1.2e-52	188.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1XRT5@135619|Oceanospirillales	135619|Oceanospirillales	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_4,Response_reg
k59_1506184_1	261292.Nit79A3_2959	4.01e-84	267.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,372QB@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_1097399_1	882378.RBRH_01992	8.55e-76	243.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1K3N3@119060|Burkholderiaceae	28216|Betaproteobacteria	JKL	DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlE	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_559635_1	1306174.JODP01000032_gene4015	6.34e-06	51.2	COG4965@1|root,COG4965@2|Bacteria,2I3KW@201174|Actinobacteria	201174|Actinobacteria	U	Type ii secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
k59_559635_2	743718.Isova_1000	1.18e-13	70.9	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4F42V@85017|Promicromonosporaceae	201174|Actinobacteria	U	Type II/IV secretion system protein	cpaF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
k59_1340410_1	1246445.ANAY01000012_gene24	0.000434	42.7	COG1703@1|root,COG1703@2|Bacteria,2GME8@201174|Actinobacteria,4EHVD@85012|Streptosporangiales	201174|Actinobacteria	E	ArgK protein	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
k59_1340410_2	397278.JOJN01000002_gene762	1.74e-51	183.0	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4DNX8@85009|Propionibacteriales	201174|Actinobacteria	G	Glycosyl hydrolase family 65 central catalytic domain	-	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
k59_1143235_1	247156.NFA_9200	2.05e-29	109.0	COG0219@1|root,COG0219@2|Bacteria,2IHN9@201174|Actinobacteria,4G0KA@85025|Nocardiaceae	201174|Actinobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	spoU	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
k59_1143235_2	685727.REQ_27040	3.18e-63	206.0	COG3214@1|root,COG3214@2|Bacteria,2I5MD@201174|Actinobacteria,4FW8Z@85025|Nocardiaceae	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
k59_559639_2	935840.JAEQ01000001_gene3117	7.71e-14	75.5	28Q4X@1|root,2ZCN0@2|Bacteria,1RA2A@1224|Proteobacteria,2U5RP@28211|Alphaproteobacteria,43JRF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1676375_1	944481.JAFP01000001_gene953	5.61e-07	50.4	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria,2M6UC@213113|Desulfurellales	28221|Deltaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_1676375_2	247633.GP2143_07494	3.24e-21	95.9	COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria,1J5TI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins	zipA	GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0022402,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032506,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047	-	ko:K03528	-	-	-	-	ko00000,ko03036	-	-	-	ZipA_C
k59_501086_1	292415.Tbd_2673	4.12e-69	220.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2VKXN@28216|Betaproteobacteria,1KRKN@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
k59_618293_1	644282.Deba_1961	7.39e-70	229.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_1506225_1	1151122.AQYD01000006_gene1625	5.07e-22	89.0	2EBAX@1|root,335BK@2|Bacteria,2GS1K@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_501092_1	1279015.KB908457_gene2290	1.89e-32	115.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,1Y4D0@135624|Aeromonadales	135624|Aeromonadales	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
k59_501092_2	396588.Tgr7_2051	2.35e-26	106.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1WWD4@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_1441418_1	713586.KB900536_gene1907	2.33e-37	134.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1WWQ1@135613|Chromatiales	135613|Chromatiales	H	Belongs to the ribF family	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
k59_1441418_2	1523503.JPMY01000010_gene2730	1.39e-14	77.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010876,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0030203,GO:0031224,GO:0031226,GO:0033036,GO:0034203,GO:0034204,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097035,GO:1901135,GO:1901137,GO:1901264,GO:1901505,GO:1901564,GO:1901566,GO:1901576	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	iECO103_1326.ECO103_1114	MVIN
k59_1340457_1	1193181.BN10_1070040	2.22e-21	92.4	COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria,4FEXA@85021|Intrasporangiaceae	201174|Actinobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	GO:0008150,GO:0040007	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_1340457_2	367299.JOEE01000011_gene3215	2.67e-37	130.0	COG4420@1|root,COG4420@2|Bacteria,2GJRV@201174|Actinobacteria,4FGJR@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
k59_1271915_1	1304885.AUEY01000002_gene367	1.9e-102	322.0	COG5164@1|root,COG5164@2|Bacteria,1MX1Z@1224|Proteobacteria,42QIV@68525|delta/epsilon subdivisions,2WKX2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_49402_1	1122135.KB893134_gene3576	4.36e-79	245.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2TU5X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	kdsD	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
k59_736497_1	867903.ThesuDRAFT_00878	2.04e-52	178.0	COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia	186801|Clostridia	L	PFAM transposase, mutator	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1381393_1	553385.JEMF01000078_gene628	1.28e-49	170.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RNPX@1236|Gammaproteobacteria,1XI1W@135619|Oceanospirillales	135619|Oceanospirillales	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
k59_1381393_2	1415754.JQMK01000002_gene2160	5.64e-67	213.0	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,1RNNZ@1236|Gammaproteobacteria,4671A@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG1176 ABC-type spermidine putrescine transport system, permease component I	potB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015399,GO:0015405,GO:0015417,GO:0015595,GO:0015606,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0015848,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098533,GO:0098655,GO:0098796,GO:0098797,GO:1902047,GO:1902494,GO:1902495,GO:1903711,GO:1904949,GO:1990351	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	iE2348C_1286.E2348C_1266,iECUMN_1333.ECUMN_1368,iSBO_1134.SBO_1916	BPD_transp_1
k59_49405_1	880072.Desac_1393	2.65e-110	332.0	COG1109@1|root,COG1109@2|Bacteria,1QUGD@1224|Proteobacteria,43BUU@68525|delta/epsilon subdivisions	1224|Proteobacteria	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1557204_1	590998.Celf_2151	2.21e-54	181.0	COG0483@1|root,COG0483@2|Bacteria,2GJQE@201174|Actinobacteria,4F0ZJ@85016|Cellulomonadaceae	201174|Actinobacteria	G	Inositol monophosphatase family	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_1097448_1	349521.HCH_00749	8.34e-38	136.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,1RQDH@1236|Gammaproteobacteria,1XH4P@135619|Oceanospirillales	135619|Oceanospirillales	P	Phosphate-binding protein	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_149579_1	765911.Thivi_3897	2.96e-132	407.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,1WW9S@135613|Chromatiales	135613|Chromatiales	E	Bacterial transglutaminase-like N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
k59_1868700_1	717785.HYPMC_1423	2.23e-80	259.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,2TRGM@28211|Alphaproteobacteria,3N61N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_677865_1	1397528.Q671_10590	5.12e-36	125.0	COG3436@1|root,COG3436@2|Bacteria,1N7AY@1224|Proteobacteria,1SD05@1236|Gammaproteobacteria,1XM3Y@135619|Oceanospirillales	135619|Oceanospirillales	L	IS66 Orf2 like protein	-	-	-	-	-	-	-	-	-	-	-	-	TnpB_IS66
k59_149581_1	768671.ThimaDRAFT_3099	2.31e-47	161.0	COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,1RYI1@1236|Gammaproteobacteria,1X255@135613|Chromatiales	135613|Chromatiales	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_149581_2	713586.KB900536_gene1105	4.73e-23	98.2	COG1653@1|root,COG1653@2|Bacteria,1R5DC@1224|Proteobacteria,1SZEG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
k59_107201_1	754476.Q7A_544	1.48e-72	236.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,4603W@72273|Thiotrichales	72273|Thiotrichales	M	PFAM Transglycosylase SLT domain	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_400712_1	631362.Thi970DRAFT_04259	3.03e-28	114.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1WW89@135613|Chromatiales	135613|Chromatiales	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
k59_400712_2	391615.ABSJ01000037_gene956	1.28e-36	129.0	COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,1S90K@1236|Gammaproteobacteria,1J6HT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	COG0848 Biopolymer transport protein	exbD1	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_208103_2	316067.Geob_3055	1.62e-05	49.3	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,42RS9@68525|delta/epsilon subdivisions,2WP93@28221|Deltaproteobacteria,43VAZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
k59_929126_1	1095767.CAHD01000193_gene175	6.37e-91	281.0	COG0327@1|root,COG0327@2|Bacteria,2GKHZ@201174|Actinobacteria,4F0E5@85016|Cellulomonadaceae	201174|Actinobacteria	S	Belongs to the GTP cyclohydrolase I type 2 NIF3 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	NIF3
k59_1868717_2	446466.Cfla_2938	4.22e-08	57.4	COG1028@1|root,COG1028@2|Bacteria,2GJCZ@201174|Actinobacteria,4F13K@85016|Cellulomonadaceae	201174|Actinobacteria	IQ	PFAM short-chain dehydrogenase reductase SDR	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_501115_1	471853.Bcav_0001	2.93e-57	194.0	COG0593@1|root,COG0593@2|Bacteria,2GJKI@201174|Actinobacteria	201174|Actinobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C
k59_929134_1	1347086.CCBA010000010_gene1698	5.13e-17	82.4	COG1028@1|root,COG1028@2|Bacteria,1TPTY@1239|Firmicutes,4HJE4@91061|Bacilli,1ZQX4@1386|Bacillus	91061|Bacilli	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1506268_1	1385521.N803_00480	3.46e-12	70.9	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4FFEV@85021|Intrasporangiaceae	201174|Actinobacteria	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_1506268_2	1121022.ABENE_18120	4.08e-08	58.5	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TS80@28211|Alphaproteobacteria,2KFQ4@204458|Caulobacterales	204458|Caulobacterales	P	CBS domain containing protein	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_107223_1	335543.Sfum_1566	5.85e-58	181.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,42TGC@68525|delta/epsilon subdivisions,2WQ2G@28221|Deltaproteobacteria,2MS2M@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
k59_107223_2	335543.Sfum_1567	2.82e-19	82.4	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,42QS6@68525|delta/epsilon subdivisions,2WMPD@28221|Deltaproteobacteria,2MR25@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_208111_1	443254.Marpi_0359	2.35e-49	177.0	COG0495@1|root,COG0495@2|Bacteria,2GC3Z@200918|Thermotogae	200918|Thermotogae	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1271950_1	765912.Thimo_2040	1.71e-94	293.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales	135613|Chromatiales	I	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_325342_1	1088721.NSU_3667	1.7e-13	67.4	COG2346@1|root,COG2346@2|Bacteria,1Q6XQ@1224|Proteobacteria,2U9CB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
k59_325342_2	1232683.ADIMK_3344	8.02e-17	82.0	COG2114@1|root,COG2114@2|Bacteria,1QWNC@1224|Proteobacteria,1S3UK@1236|Gammaproteobacteria,468QZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1,4.6.1.2	ko:K01768,ko:K01769	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
k59_1340526_1	472759.Nhal_0131	4.75e-73	246.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RQ0G@1236|Gammaproteobacteria,1WXEX@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_682646_1	1117314.PCIT_19474	8.67e-24	108.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,2Q1ST@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	G	COG2211 Na melibiose symporter and related transporters	yicJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
k59_1680854_1	318167.Sfri_0258	1.43e-110	334.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,2Q8ZR@267890|Shewanellaceae	1236|Gammaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
k59_288550_1	500640.CIT292_08736	1.82e-86	266.0	COG3007@1|root,COG3007@2|Bacteria,1MWCQ@1224|Proteobacteria,1RPPP@1236|Gammaproteobacteria,3WXUV@544|Citrobacter	1236|Gammaproteobacteria	I	Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP)	fabV	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050343,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.3.1.44,1.3.1.9	ko:K00209	ko00061,ko00650,ko01100,ko01120,ko01200,ko01212,map00061,map00650,map01100,map01120,map01200,map01212	M00083	R01171,R04429,R04724,R04955,R04958,R04961,R04966,R04969	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Eno-Rase_FAD_bd,Eno-Rase_NADH_b,Enoyl_reductase
k59_1445877_1	1510531.JQJJ01000011_gene2695	6.05e-59	187.0	COG1956@1|root,COG1956@2|Bacteria,1RDBM@1224|Proteobacteria,2U595@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG1956 GAF domain-containing protein	msrC	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF_2
k59_154402_1	1120949.KB903302_gene6582	1.41e-15	77.8	COG2197@1|root,COG2197@2|Bacteria,2IBDE@201174|Actinobacteria,4D9GH@85008|Micromonosporales	201174|Actinobacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1347430_1	232721.Ajs_1240	1.57e-10	65.5	COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,2VIUK@28216|Betaproteobacteria,4AA0N@80864|Comamonadaceae	28216|Betaproteobacteria	P	Iron permease FTR1	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	Cytochrome_CBB3,FTR1
k59_1347430_2	748247.AZKH_0100	0.000399	43.5	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,2KVKK@206389|Rhodocyclales	206389|Rhodocyclales	P	P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
k59_857905_2	765910.MARPU_00820	5.27e-56	192.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales	135613|Chromatiales	I	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_1511284_1	1121468.AUBR01000029_gene1577	2.45e-65	211.0	COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,42FDK@68295|Thermoanaerobacterales	186801|Clostridia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06430	GcpE
k59_1875647_1	388051.AUFE01000022_gene4758	7.17e-39	133.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,2VUC8@28216|Betaproteobacteria,1K8SA@119060|Burkholderiaceae	28216|Betaproteobacteria	P	tolerance protein	cutA	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
k59_1875647_2	338969.Rfer_1618	4.36e-22	92.4	COG3639@1|root,COG3639@2|Bacteria,1MW4F@1224|Proteobacteria,2VKCA@28216|Betaproteobacteria,4AAV0@80864|Comamonadaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	phnE	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
k59_447140_1	1163617.SCD_n02853	8.51e-177	503.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
k59_1794687_1	367299.JOEE01000007_gene229	7.7e-137	389.0	COG0479@1|root,COG0479@2|Bacteria,2GJPS@201174|Actinobacteria,4FEDH@85021|Intrasporangiaceae	201174|Actinobacteria	C	succinate dehydrogenase	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
k59_1738445_1	765912.Thimo_3336	4.15e-228	644.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,1T2DW@1236|Gammaproteobacteria,1X2PB@135613|Chromatiales	135613|Chromatiales	EQ	PFAM Hydantoinase B oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_994935_2	1123228.AUIH01000002_gene1608	1.43e-15	77.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria,1XHV3@135619|Oceanospirillales	135619|Oceanospirillales	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
k59_857917_1	626887.J057_23810	9.98e-28	109.0	2DC7W@1|root,2ZD7C@2|Bacteria,1QU8S@1224|Proteobacteria,1S6MA@1236|Gammaproteobacteria,46BPC@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Chalcone isomerase-like	-	-	-	-	-	-	-	-	-	-	-	-	Chalcone_3
k59_1561952_1	1121935.AQXX01000106_gene526	4.82e-34	126.0	COG3471@1|root,COG3471@2|Bacteria,1MZA2@1224|Proteobacteria,1S793@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	periplasmic secreted protein	Z012_10940	-	-	-	-	-	-	-	-	-	-	-	SIMPL
k59_1561952_2	765913.ThidrDRAFT_0128	1.24e-38	132.0	COG1765@1|root,COG1765@2|Bacteria,1N1RR@1224|Proteobacteria,1S3KI@1236|Gammaproteobacteria,1WY57@135613|Chromatiales	135613|Chromatiales	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
k59_994943_1	880072.Desac_2167	8.16e-123	358.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MRV@68525|delta/epsilon subdivisions,2WK9C@28221|Deltaproteobacteria,2MR5B@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	porB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
k59_1738453_1	1049564.TevJSym_bg00310	1.63e-75	231.0	COG1845@1|root,COG1845@2|Bacteria,1RG3S@1224|Proteobacteria,1S75W@1236|Gammaproteobacteria,1JADH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c oxidase subunit III	nirO	-	1.9.3.1	ko:K02164,ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081,R00294	RC00016,RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10,3.D.4.4,3.D.4.6	-	-	COX3
k59_55769_2	1121448.DGI_1815	2.23e-34	128.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,42SJR@68525|delta/epsilon subdivisions,2WRRB@28221|Deltaproteobacteria,2M841@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1445901_1	1121405.dsmv_0087	1.69e-110	333.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,42MTY@68525|delta/epsilon subdivisions,2WKII@28221|Deltaproteobacteria,2MI2W@213118|Desulfobacterales	28221|Deltaproteobacteria	J	TIGRFAM arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_1434	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_857922_1	1194165.CAJF01000005_gene2291	4.48e-73	237.0	COG0265@1|root,COG0265@2|Bacteria,2IB8S@201174|Actinobacteria	201174|Actinobacteria	O	Trypsin-like peptidase domain	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_741333_1	177437.HRM2_38760	2.61e-120	355.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,42MB7@68525|delta/epsilon subdivisions,2WJVU@28221|Deltaproteobacteria,2MI80@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Aminotransferase class-III	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1029651_1	1197706.AKKK01000058_gene1445	9.34e-39	141.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,CarboxypepD_reg,FTP,PepSY,SLH,VCBS
k59_935711_1	526226.Gbro_2726	9.07e-35	129.0	COG0842@1|root,COG0842@2|Bacteria,2GJ7Y@201174|Actinobacteria,4GCQ2@85026|Gordoniaceae	201174|Actinobacteria	U	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
k59_935711_2	1120949.KB903306_gene7224	1.79e-09	59.3	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4DA8J@85008|Micromonosporales	201174|Actinobacteria	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_447168_1	335543.Sfum_1324	6.63e-58	193.0	COG4012@1|root,COG4012@2|Bacteria,1R94F@1224|Proteobacteria,42Q7K@68525|delta/epsilon subdivisions,2WK3Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Domain of unkown function DUF1786	-	-	-	-	-	-	-	-	-	-	-	-	DUF1786
k59_1680887_1	999541.bgla_1g08700	6.79e-10	60.5	COG0837@1|root,COG1737@1|root,COG0837@2|Bacteria,COG1737@2|Bacteria,1MVFI@1224|Proteobacteria,2VH5F@28216|Betaproteobacteria,1K3IA@119060|Burkholderiaceae	28216|Betaproteobacteria	F	belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase,HTH_6,SIS
k59_1680887_2	521719.ATXQ01000005_gene1560	3.96e-21	95.9	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,1RPAE@1236|Gammaproteobacteria,1YF68@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Universal stress protein family	ydaA	-	-	ko:K14055	-	-	-	-	ko00000	-	-	-	Usp
k59_288596_1	1120949.KB903294_gene3590	2.13e-63	211.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4D964@85008|Micromonosporales	201174|Actinobacteria	L	Transposase, Mutator family	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_55783_1	1049564.TevJSym_bm00110	1.72e-60	194.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1RQ1J@1236|Gammaproteobacteria,1J609@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	letA	-	-	ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_1147506_2	596152.DesU5LDRAFT_0048	1.2e-14	74.7	COG1216@1|root,COG2327@1|root,COG1216@2|Bacteria,COG2327@2|Bacteria,1RHX9@1224|Proteobacteria	1224|Proteobacteria	S	Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
k59_505842_1	278963.ATWD01000001_gene2699	5.74e-13	70.5	COG3264@1|root,COG3264@2|Bacteria,3Y5SA@57723|Acidobacteria,2JMSI@204432|Acidobacteriia	204432|Acidobacteriia	M	Mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
k59_505842_2	903818.KI912268_gene1348	2.8e-56	187.0	COG0598@1|root,COG0598@2|Bacteria	2|Bacteria	P	Magnesium transport protein CorA	zntB	GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662	-	ko:K03284,ko:K16074	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3,1.A.35.4	-	-	CorA
k59_857936_1	335543.Sfum_3526	6.35e-68	217.0	COG0392@1|root,COG0392@2|Bacteria,1RCGI@1224|Proteobacteria,42RDB@68525|delta/epsilon subdivisions,2WMU8@28221|Deltaproteobacteria,2MRE1@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
k59_407650_1	519989.ECTPHS_06587	2.05e-15	70.1	COG3197@1|root,COG3197@2|Bacteria,1NG90@1224|Proteobacteria	1224|Proteobacteria	P	Cytochrome oxidase maturation protein	ccoS	-	-	-	-	-	-	-	-	-	-	-	FixS
k59_407650_2	2340.JV46_28240	6.24e-117	363.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J595@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	cation transport ATPase	ccoI	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_505844_1	118161.KB235922_gene5415	5.11e-169	479.0	COG0667@1|root,COG0667@2|Bacteria,1G1J4@1117|Cyanobacteria,3VJ2Z@52604|Pleurocapsales	1117|Cyanobacteria	C	PFAM Aldo keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1102566_1	1517416.IDAT_07945	1.33e-229	658.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,2QFQJ@267893|Idiomarinaceae	1236|Gammaproteobacteria	J	due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iECOK1_1307.ECOK1_0652,iECS88_1305.ECS88_0684,iNRG857_1313.NRG857_02925,iPC815.YPO2610	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_935739_1	1380355.JNIJ01000041_gene5260	5.66e-50	169.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,2U24Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
k59_935739_2	622637.KE124774_gene3528	1.76e-16	77.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,2U24Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
k59_622994_1	448385.sce9162	1.52e-29	119.0	COG3385@1|root,COG3385@2|Bacteria,1MXYG@1224|Proteobacteria,430KD@68525|delta/epsilon subdivisions,2WVSS@28221|Deltaproteobacteria,2YZ09@29|Myxococcales	28221|Deltaproteobacteria	L	High confidence in function and specificity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4338,Dimer_Tnp_Tn5,Tnp_DNA_bind
k59_793450_1	637389.Acaty_m0148	1.81e-40	149.0	COG3335@1|root,COG3335@2|Bacteria,1MW8A@1224|Proteobacteria,1RY10@1236|Gammaproteobacteria,2NCKJ@225057|Acidithiobacillales	225057|Acidithiobacillales	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_33
k59_682719_1	768671.ThimaDRAFT_1403	8.21e-76	241.0	COG1109@1|root,COG1109@2|Bacteria,1MUB3@1224|Proteobacteria,1RNFZ@1236|Gammaproteobacteria,1WVYP@135613|Chromatiales	135613|Chromatiales	G	alpha beta alpha domain I	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_505856_1	1049564.TevJSym_ac00070	6.71e-20	89.0	COG0348@1|root,COG0348@2|Bacteria,1MWR5@1224|Proteobacteria,1SJST@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
k59_505856_2	563040.Saut_1985	0.000157	45.8	COG1143@1|root,COG1149@1|root,COG1143@2|Bacteria,COG1149@2|Bacteria,1QWGE@1224|Proteobacteria	1224|Proteobacteria	C	4Fe-4S binding domain	-	-	-	ko:K02573	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4,Fer4_7
k59_742194_1	203122.Sde_2433	7.44e-36	131.0	28PSV@1|root,2ZCE8@2|Bacteria,1RCPN@1224|Proteobacteria,1S2WS@1236|Gammaproteobacteria,46AJK@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_447972_1	1120970.AUBZ01000013_gene1824	7.59e-57	184.0	COG0625@1|root,COG0625@2|Bacteria,1PHM1@1224|Proteobacteria,1RMVC@1236|Gammaproteobacteria,4671Z@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N,GST_N_3
k59_996175_1	266834.SM_b20088	1.55e-37	145.0	COG2312@1|root,COG2518@1|root,COG2312@2|Bacteria,COG2518@2|Bacteria,1MU2S@1224|Proteobacteria,2TWB5@28211|Alphaproteobacteria,4BBC7@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	Erythro_esteras,PCMT,Pribosyltran
k59_1277927_1	1111479.AXAR01000029_gene1469	1.04e-38	137.0	COG3328@1|root,COG3328@2|Bacteria,1VQ2G@1239|Firmicutes,4I131@91061|Bacilli	91061|Bacilli	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_56728_1	335543.Sfum_3195	3.25e-61	207.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42MYN@68525|delta/epsilon subdivisions,2WIND@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1348693_1	443152.MDG893_05264	4.92e-14	75.9	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,4658H@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_936913_1	717785.HYPMC_4126	3.37e-70	224.0	COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,2TSV7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
k59_936916_1	593907.Celgi_2319	5.84e-23	92.8	2CXFQ@1|root,32T1V@2|Bacteria,2GQYH@201174|Actinobacteria,4F1HG@85016|Cellulomonadaceae	201174|Actinobacteria	S	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
k59_936916_2	471853.Bcav_2788	4.44e-22	86.7	2EG89@1|root,33A03@2|Bacteria,2GX3U@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_56733_1	243233.MCA2174	5.51e-67	214.0	COG0803@1|root,COG0803@2|Bacteria,1RAQU@1224|Proteobacteria	1224|Proteobacteria	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
k59_1386942_1	1121875.KB907546_gene2199	1.07e-74	242.0	COG3653@1|root,COG3653@2|Bacteria,4NHDD@976|Bacteroidetes,1I2RR@117743|Flavobacteriia	976|Bacteroidetes	Q	PFAM D-aminoacylase, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_115341_2	371042.NG99_13985	7.71e-46	166.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,3X6CE@551|Erwinia	1236|Gammaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
k59_1277933_1	219305.MCAG_03984	7.84e-40	149.0	COG2826@1|root,COG2826@2|Bacteria,2GMZX@201174|Actinobacteria,4DA2E@85008|Micromonosporales	201174|Actinobacteria	L	Transposase and inactivated derivatives IS30 family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_1876984_1	1280953.HOC_19316	2.44e-50	162.0	COG3293@1|root,COG3293@2|Bacteria,1MYPD@1224|Proteobacteria,2UBMY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2
k59_1876984_2	1114964.L485_18385	5.19e-49	160.0	COG3293@1|root,COG3293@2|Bacteria,1RDDI@1224|Proteobacteria,2UAE0@28211|Alphaproteobacteria,2K6GM@204457|Sphingomonadales	204457|Sphingomonadales	L	COG3293 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_1512119_1	1304885.AUEY01000134_gene1489	2.37e-79	253.0	COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,43CRI@68525|delta/epsilon subdivisions,2X7Z7@28221|Deltaproteobacteria,2MIWI@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_1348714_1	143224.JQMD01000002_gene3430	9.63e-84	263.0	COG2160@1|root,COG2160@2|Bacteria,4NHGG@976|Bacteroidetes,1HYCR@117743|Flavobacteriia	976|Bacteroidetes	G	Catalyzes the conversion of L-arabinose to L-ribulose	araA	-	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	-	Arabinose_Iso_C,Arabinose_Isome
k59_115349_1	525897.Dbac_0975	1.37e-46	169.0	COG3290@1|root,COG4191@1|root,COG3290@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WKC0@28221|Deltaproteobacteria,2M7TX@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K10819	-	-	-	-	ko00000,ko01000	-	-	-	HATPase_c,HisKA,PAS_8,PAS_9,sCache_3_2
k59_56743_1	105559.Nwat_1826	6.46e-36	127.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,1S61C@1236|Gammaproteobacteria,1WY06@135613|Chromatiales	135613|Chromatiales	I	Cyclase dehydrase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
k59_56743_2	1123228.AUIH01000009_gene1990	1.39e-19	81.6	COG2914@1|root,COG2914@2|Bacteria,1MZCH@1224|Proteobacteria,1SCHG@1236|Gammaproteobacteria,1XKZ3@135619|Oceanospirillales	135619|Oceanospirillales	S	Belongs to the UPF0125 (RnfH) family	rnfH	-	-	ko:K09801	-	-	-	-	ko00000	-	-	-	Ub-RnfH
k59_1876987_1	28072.Nos7524_1349	2.99e-19	94.0	COG2374@1|root,COG2706@1|root,COG2931@1|root,COG3210@1|root,COG3291@1|root,COG2374@2|Bacteria,COG2706@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,1GJ9G@1117|Cyanobacteria,1HR22@1161|Nostocales	1117|Cyanobacteria	QU	PFAM 3-carboxy-cis,cis-muconate lactonizing enzyme	-	-	3.4.21.10	ko:K01317	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	DUF4347,Lactonase
k59_1446678_1	1265313.HRUBRA_02301	4.63e-37	139.0	COG0204@1|root,COG0560@1|root,COG0204@2|Bacteria,COG0560@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1J8AD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase,HAD
k59_1446678_2	247634.GPB2148_898	9.83e-34	125.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	-	-	-	-	-	-	-	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_1876992_1	926556.Echvi_4543	1.16e-24	107.0	COG2911@1|root,COG2911@2|Bacteria,4NHHA@976|Bacteroidetes,47XBI@768503|Cytophagia	976|Bacteroidetes	M	Calx-beta domain	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_4,CHU_C,Calx-beta,He_PIG,NHL,TIG,fn3
k59_1211468_1	670487.Ocepr_0853	4.06e-85	265.0	COG3303@1|root,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	hao	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015975,GO:0015980,GO:0016491,GO:0016661,GO:0016663,GO:0019329,GO:0019331,GO:0034641,GO:0042597,GO:0044237,GO:0044281,GO:0044464,GO:0045333,GO:0047991,GO:0055114	1.7.2.6	ko:K10535	ko00910,ko01120,map00910,map01120	M00528,M00804	R10164	RC00383	ko00000,ko00001,ko00002,ko01000	-	-	-	Multi-haem_cyto
k59_289462_1	246195.DNO_0173	2.67e-137	419.0	COG1204@1|root,COG1204@2|Bacteria,1MW4Z@1224|Proteobacteria,1RXXN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DEAD DEAH box helicase	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
k59_1446684_2	323261.Noc_1170	3.49e-55	179.0	COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,1RMEH@1236|Gammaproteobacteria,1WWBK@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
k59_1568250_1	529818.AMSG_11381T0	1.54e-38	148.0	COG0265@1|root,KOG1421@2759|Eukaryota	2759|Eukaryota	O	serine-type endopeptidase activity	NMA111	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0006629,GO:0006807,GO:0006915,GO:0006950,GO:0008150,GO:0008152,GO:0008219,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009416,GO:0009507,GO:0009536,GO:0009628,GO:0009642,GO:0009644,GO:0009892,GO:0009987,GO:0010109,GO:0010205,GO:0012501,GO:0016787,GO:0017171,GO:0019222,GO:0019538,GO:0030163,GO:0031323,GO:0031324,GO:0033554,GO:0034605,GO:0042548,GO:0043155,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043467,GO:0044237,GO:0044238,GO:0044248,GO:0044255,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051603,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1905156	-	-	-	-	-	-	-	-	-	-	PDZ,PDZ_1,PDZ_2,Trypsin_2
k59_1687558_1	2340.JV46_11900	1.63e-20	89.4	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1T02D@1236|Gammaproteobacteria,1J5J9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the dihydroorotate dehydrogenase family	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,NAD_binding_1
k59_1687558_2	768671.ThimaDRAFT_2572	1.02e-36	124.0	2C2HW@1|root,32U3B@2|Bacteria,1N2W5@1224|Proteobacteria,1SA05@1236|Gammaproteobacteria,1WYXJ@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_629689_1	1030157.AFMP01000016_gene2492	4.98e-15	79.7	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2TR6F@28211|Alphaproteobacteria,2K1W8@204457|Sphingomonadales	204457|Sphingomonadales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_1284749_1	768671.ThimaDRAFT_2563	1.7e-61	194.0	COG0693@1|root,COG0693@2|Bacteria,1N7T2@1224|Proteobacteria,1RSBI@1236|Gammaproteobacteria,1WY2E@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM DJ-1 family protein	-	-	3.5.1.124	ko:K03152	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
k59_1800208_1	637390.AFOH01000010_gene794	1.17e-92	278.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,2NCX3@225057|Acidithiobacillales	225057|Acidithiobacillales	S	L,D-transpeptidase catalytic domain	-	-	-	ko:K16291	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	LysM,YkuD
k59_1518780_1	748658.KB907316_gene458	4.22e-20	90.9	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1WX79@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
k59_1518780_2	1121937.AUHJ01000002_gene3539	0.000627	43.1	28Q6S@1|root,2ZCPQ@2|Bacteria,1PA2R@1224|Proteobacteria,1SUJ9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1217325_1	378753.KRH_10450	8.27e-48	161.0	COG1399@1|root,COG1399@2|Bacteria,2GJTS@201174|Actinobacteria,1W94D@1268|Micrococcaceae	201174|Actinobacteria	S	Uncharacterized ACR, COG1399	-	GO:0008150,GO:0040007	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
k59_798366_1	498211.CJA_3511	2.94e-71	222.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RQQ3@1236|Gammaproteobacteria,1FGJ2@10|Cellvibrio	1236|Gammaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483,ko:K07666	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_798366_3	983545.Glaag_3247	1.64e-06	52.4	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,466MP@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	yqgE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_1110082_1	1051632.TPY_2225	9.05e-06	47.4	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve,rve_3
k59_1110082_2	1336249.JADW01000056_gene4193	4.28e-29	108.0	COG2963@1|root,COG2963@2|Bacteria,1RI5X@1224|Proteobacteria,2UBB0@28211|Alphaproteobacteria,4BHNS@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_570758_1	768671.ThimaDRAFT_3864	2.47e-87	259.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,1S20I@1236|Gammaproteobacteria,1WXGS@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM Acetolactate synthase, small subunit	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5,ALS_ss_C
k59_1154202_2	1313172.YM304_09830	1.31e-47	160.0	COG0003@1|root,COG0003@2|Bacteria,2GJ0J@201174|Actinobacteria,4CMZD@84992|Acidimicrobiia	84992|Acidimicrobiia	P	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
k59_1393526_1	1415780.JPOG01000001_gene2060	6.68e-52	168.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,1RPW7@1236|Gammaproteobacteria,1X3RR@135614|Xanthomonadales	135614|Xanthomonadales	J	Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
k59_1688733_1	765912.Thimo_0165	1.03e-173	486.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,1RN7C@1236|Gammaproteobacteria,1WWX8@135613|Chromatiales	135613|Chromatiales	S	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
k59_689951_1	1049564.TevJSym_al00490	3.35e-22	100.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,1J5F4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	internalization-related competence protein ComEC Rec2	ycaI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_513310_1	1177179.A11A3_07890	1.4e-72	230.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1XH97@135619|Oceanospirillales	135619|Oceanospirillales	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1453811_1	203275.BFO_2085	5.45e-86	269.0	COG3039@1|root,COG3039@2|Bacteria,4NHF4@976|Bacteroidetes,2FN6F@200643|Bacteroidia,22YR6@171551|Porphyromonadaceae	976|Bacteroidetes	L	hmm pf01609	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_1688741_1	1424334.W822_18790	6.81e-24	105.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,3T1BB@506|Alcaligenaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1520257_1	768671.ThimaDRAFT_3618	3.73e-66	211.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1WWWF@135613|Chromatiales	135613|Chromatiales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_454554_1	641491.DND132_3366	2.42e-42	150.0	COG4822@1|root,COG4822@2|Bacteria,1P36Y@1224|Proteobacteria,42P9C@68525|delta/epsilon subdivisions,2WK8C@28221|Deltaproteobacteria,2M9VK@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the insertion of Co(2 ) into sirohydrochlorin	cbiKp	GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0009987,GO:0016043,GO:0016829,GO:0016852,GO:0020037,GO:0022607,GO:0042597,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050897,GO:0051259,GO:0051262,GO:0051266,GO:0065003,GO:0071840,GO:0097159,GO:1901363	4.99.1.3	ko:K02190	ko00860,ko01100,map00860,map01100	-	R05807	RC01012	ko00000,ko00001,ko01000	-	-	-	CbiK
k59_1393545_1	748247.AZKH_4121	4.66e-21	95.9	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2VMHQ@28216|Betaproteobacteria,2KXGP@206389|Rhodocyclales	206389|Rhodocyclales	M	Subtilase family	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
k59_865967_1	880072.Desac_2669	1.14e-85	261.0	COG1073@1|root,COG1073@2|Bacteria,1RBV1@1224|Proteobacteria,42M9M@68525|delta/epsilon subdivisions,2WM64@28221|Deltaproteobacteria,2MQDT@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
k59_1393550_1	446466.Cfla_2808	2.31e-75	239.0	COG2271@1|root,COG2271@2|Bacteria,2GK3N@201174|Actinobacteria	201174|Actinobacteria	G	Major facilitator superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
k59_161873_1	864051.BurJ1DRAFT_2141	6.73e-76	253.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,1KJQB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07239,ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1,2.A.6.1.2	-	-	ACR_tran
k59_1453848_1	396588.Tgr7_1015	4.35e-27	114.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,1RPDC@1236|Gammaproteobacteria,1WWR8@135613|Chromatiales	135613|Chromatiales	S	PFAM Bacterial domain of	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
k59_1520293_1	644282.Deba_0689	4.12e-111	328.0	COG0694@1|root,COG0822@1|root,COG1251@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,COG1251@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2WJBU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CO	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins	nifU	-	-	ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
k59_1569559_1	593907.Celgi_0733	2.75e-102	308.0	COG1169@1|root,COG1169@2|Bacteria,2GKE8@201174|Actinobacteria,4F0VS@85016|Cellulomonadaceae	201174|Actinobacteria	HQ	chorismate binding enzyme	menF	-	5.4.4.2	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
k59_1801199_1	1254432.SCE1572_24150	6.26e-102	313.0	2DSHD@1|root,33G4R@2|Bacteria	2|Bacteria	-	-	-	-	1.13.11.33	ko:K19246	ko00590,ko01100,map00590,map01100	-	R01593	RC00561	ko00000,ko00001,ko01000	-	-	-	Lipoxygenase
k59_1801199_2	1349767.GJA_1309	2.02e-19	87.0	COG1073@1|root,COG1073@2|Bacteria,1QUD5@1224|Proteobacteria,2VIVS@28216|Betaproteobacteria,475V8@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Prolyl oligopeptidase family	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Hydrolase_4
k59_1218522_1	1049564.TevJSym_al00200	1.72e-134	399.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1J5XD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3
k59_1627653_1	1267005.KB911258_gene154	1.06e-48	166.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,2TT31@28211|Alphaproteobacteria,3N80Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	4Fe-4S single cluster domain	kamA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
k59_1627653_2	754035.Mesau_04850	8.16e-43	144.0	COG3791@1|root,COG3791@2|Bacteria,1RE8S@1224|Proteobacteria,2U73V@28211|Alphaproteobacteria,43JQD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_454570_1	1429046.RR21198_5677	3.34e-40	160.0	COG1461@1|root,COG1461@2|Bacteria,2GKII@201174|Actinobacteria,4FWU1@85025|Nocardiaceae	201174|Actinobacteria	S	Dak1_2	dak3	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
k59_161879_1	1396141.BATP01000056_gene3151	0.000194	46.6	COG0664@1|root,COG0664@2|Bacteria,46VK1@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Transcriptional regulator, Crp Fnr family	-	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_161879_2	765910.MARPU_03120	4.13e-25	96.7	2APA5@1|root,31EC7@2|Bacteria,1RHMQ@1224|Proteobacteria,1S7US@1236|Gammaproteobacteria,1WYJ6@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1037893_1	991905.SL003B_1457	2.16e-98	301.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2TQXA@28211|Alphaproteobacteria,4BP5F@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_1393573_1	1335757.SPICUR_01555	6.73e-14	75.5	COG3161@1|root,COG3161@2|Bacteria,1N8BF@1224|Proteobacteria,1SDX2@1236|Gammaproteobacteria,1X1RG@135613|Chromatiales	135613|Chromatiales	H	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway	ubiC	-	4.1.3.40	ko:K03181	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R01302	RC00491,RC02148	ko00000,ko00001,ko00002,ko01000	-	-	-	Chor_lyase
k59_1037901_1	1278309.KB907103_gene1062	4.82e-30	118.0	COG1073@1|root,COG1073@2|Bacteria,1R76C@1224|Proteobacteria,1RR34@1236|Gammaproteobacteria,1XINP@135619|Oceanospirillales	135619|Oceanospirillales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_866005_1	1122130.AUHN01000008_gene1456	3.81e-69	218.0	COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the TrpC family	trpC	GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
k59_1037908_1	443906.CMM_0394	1.32e-14	80.1	COG4861@1|root,COG4861@2|Bacteria,2INUD@201174|Actinobacteria,4FPKY@85023|Microbacteriaceae	201174|Actinobacteria	S	Transcriptional regulator, AbiEi antitoxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_2
k59_1569571_1	1265313.HRUBRA_01605	3.97e-59	191.0	COG1442@1|root,COG1442@2|Bacteria,1R5NA@1224|Proteobacteria,1SISQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1569571_2	570967.JMLV01000001_gene2799	3.99e-126	370.0	2DG8R@1|root,2ZUYV@2|Bacteria,1R8VA@1224|Proteobacteria,2VGKJ@28211|Alphaproteobacteria,2JZ9B@204441|Rhodospirillales	204441|Rhodospirillales	H	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
k59_690003_1	1385517.N800_04685	5.51e-86	282.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X34J@135614|Xanthomonadales	135614|Xanthomonadales	V	Efflux pump membrane transporter	mexB	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1520328_1	644282.Deba_2542	7.85e-119	352.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,42N9K@68525|delta/epsilon subdivisions,2WINH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM N-6 DNA methylase	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
k59_866019_1	589865.DaAHT2_0922	1.5e-62	205.0	COG4591@1|root,COG4591@2|Bacteria,1QVSQ@1224|Proteobacteria,43BSZ@68525|delta/epsilon subdivisions,2WME9@28221|Deltaproteobacteria,2MMBK@213118|Desulfobacterales	28221|Deltaproteobacteria	M	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1569574_1	380358.XALC_1431	1.12e-10	60.5	COG2747@1|root,COG2747@2|Bacteria,1NGJA@1224|Proteobacteria,1SGQ4@1236|Gammaproteobacteria,1X87M@135614|Xanthomonadales	135614|Xanthomonadales	N	Flagellar protein	flgM	-	-	ko:K02398	ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgM
k59_1569574_2	511062.GU3_13590	3.69e-23	101.0	COG1261@1|root,COG1261@2|Bacteria,1N1SA@1224|Proteobacteria,1S8SQ@1236|Gammaproteobacteria,1Y4IT@135624|Aeromonadales	135624|Aeromonadales	N	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly	flgA	-	-	ko:K02386	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	ChapFlgA
k59_454585_1	987059.RBXJA2T_07573	2.78e-240	674.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VMJK@28216|Betaproteobacteria,1KNFI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_1688825_1	925775.XVE_2276	9.83e-20	87.8	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria,1X3QB@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
k59_1688825_2	160492.XF_1292	9.66e-15	72.0	COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,1SD8H@1236|Gammaproteobacteria,1X7C1@135614|Xanthomonadales	135614|Xanthomonadales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsB	-	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
k59_1688825_3	521098.Aaci_0744	0.000128	43.9	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,4HAKI@91061|Bacilli,277WY@186823|Alicyclobacillaceae	91061|Bacilli	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0044877,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_1569594_2	1162668.LFE_1004	9.1e-15	73.2	COG0446@1|root,COG0446@2|Bacteria,3J102@40117|Nitrospirae	40117|Nitrospirae	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_161923_1	626887.J057_23305	8.21e-88	273.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,464HQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027	CBS,IMPDH,NMO
k59_1746438_1	340177.Cag_0616	1.87e-20	97.4	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Big_3_2,CHU_C,Flg_new,LRR_5
k59_571810_1	857087.Metme_2832	4.82e-136	392.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1XDWP@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_454601_1	187272.Mlg_0848	4.46e-100	302.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria,1WWMC@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
k59_454601_2	2340.JV46_24150	8.35e-18	76.6	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,1S9AI@1236|Gammaproteobacteria,1J6U6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
k59_690039_1	590998.Celf_2444	1.91e-81	248.0	COG1131@1|root,COG1131@2|Bacteria,2IJGC@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	ccmA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1393623_1	425400.LS65_05595	1.82e-26	105.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,42M0Q@68525|delta/epsilon subdivisions,2YMXU@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_1393623_2	990073.ATHU01000001_gene1706	5.01e-17	82.4	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42MS0@68525|delta/epsilon subdivisions,2YMTX@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	Diguanylate cyclase phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,dCache_3
k59_630840_1	876269.ARWA01000001_gene3709	3.3e-68	230.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria,3ND1K@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	FAD linked oxidases, C-terminal domain	MA20_43170	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_1627722_2	379731.PST_2817	2.39e-46	155.0	COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,1S9D9@1236|Gammaproteobacteria,1Z2V8@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	hit1	-	-	-	-	-	-	-	-	-	-	-	HIT
k59_1746457_1	1249627.D779_4100	7.35e-112	335.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,1WVV4@135613|Chromatiales	135613|Chromatiales	L	AAA ATPase, central domain protein	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_338253_1	521674.Plim_0046	1.05e-69	224.0	COG1413@1|root,COG1413@2|Bacteria,2IX4C@203682|Planctomycetes	203682|Planctomycetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
k59_1111574_2	457570.Nther_1013	1.97e-15	80.5	COG1680@1|root,COG1680@2|Bacteria,1TR9E@1239|Firmicutes,2480P@186801|Clostridia	186801|Clostridia	V	Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_866112_1	228405.HNE_3095	1.85e-43	155.0	COG0388@1|root,COG3153@1|root,COG0388@2|Bacteria,COG3153@2|Bacteria,1MX4I@1224|Proteobacteria,2TVMQ@28211|Alphaproteobacteria,43X9I@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
k59_1393655_1	1124780.ANNU01000008_gene2683	3.78e-64	219.0	COG1649@1|root,COG3866@1|root,COG4733@1|root,COG1649@2|Bacteria,COG3866@2|Bacteria,COG4733@2|Bacteria,4P09P@976|Bacteroidetes,47MVU@768503|Cytophagia	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_454632_1	641491.DND132_0932	1.78e-80	265.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2M86M@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM glycosyl transferase family 51	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
k59_220190_1	977880.RALTA_A1696	9.91e-136	409.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,1K0GW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_338271_1	765910.MARPU_01480	1.11e-65	204.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria,1WWWN@135613|Chromatiales	135613|Chromatiales	O	PFAM Glutathione S-transferase	sspA	-	-	ko:K03599	-	-	-	-	ko00000,ko02000,ko03021	1.A.12.3.1	-	-	GST_C,GST_C_2,GST_N_3
k59_338271_2	1109445.AGSX01000192_gene3786	7.43e-21	89.4	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1Z0RN@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	P	Cytochrome C1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
k59_1111586_1	1283300.ATXB01000001_gene1708	8.09e-81	264.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1XEPA@135618|Methylococcales	1236|Gammaproteobacteria	O	Belongs to the peptidase S16 family	-	-	-	ko:K04770	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C
k59_690080_1	1286106.MPL1_10132	3.19e-54	192.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,4602D@72273|Thiotrichales	72273|Thiotrichales	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_571857_1	891974.E05_45020	8.35e-06	52.0	COG2234@1|root,COG2234@2|Bacteria,1P2WI@1224|Proteobacteria,1RRBM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	Catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3	iap	GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005623,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K09612	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M28
k59_755879_1	269799.Gmet_2226	9.07e-12	65.1	COG1028@1|root,COG1028@2|Bacteria,1MVQW@1224|Proteobacteria,42ZR2@68525|delta/epsilon subdivisions,2WV3H@28221|Deltaproteobacteria,43V3V@69541|Desulfuromonadales	28221|Deltaproteobacteria	IQ	KR domain	-	-	1.1.1.53	ko:K00038	ko00140,ko01100,map00140,map01100	-	R04831,R04834,R04844,R04847	RC00139,RC01219,RC01220	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
k59_1159916_1	367299.JOEE01000002_gene2448	1.55e-71	221.0	COG1280@1|root,COG1280@2|Bacteria,2GMDP@201174|Actinobacteria,4FEGN@85021|Intrasporangiaceae	201174|Actinobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
k59_344379_1	314278.NB231_15163	6.49e-80	257.0	28IUD@1|root,2Z8T4@2|Bacteria,1QZHS@1224|Proteobacteria,1RNTX@1236|Gammaproteobacteria,1WW4J@135613|Chromatiales	135613|Chromatiales	S	Carboxysome shell peptide mid-region	-	-	-	-	-	-	-	-	-	-	-	-	CsoS2_M
k59_755880_1	706587.Desti_3168	1.75e-17	80.9	COG0559@1|root,COG0559@2|Bacteria,1PAWF@1224|Proteobacteria,42MQG@68525|delta/epsilon subdivisions,2WKQ5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1635076_1	1209072.ALBT01000007_gene2736	3.31e-15	79.3	COG2188@1|root,COG2188@2|Bacteria,1MUEB@1224|Proteobacteria,1T9SV@1236|Gammaproteobacteria,1FHSV@10|Cellvibrio	1236|Gammaproteobacteria	K	UTRA	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
k59_1577063_1	944560.HMPREF9058_1865	2.91e-52	196.0	COG1674@1|root,COG1674@2|Bacteria,2GJBR@201174|Actinobacteria,4D4Q6@85005|Actinomycetales	201174|Actinobacteria	D	FtsK SpoIIIE family protein	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FHA,FtsK_SpoIIIE
k59_1635082_1	633147.Olsu_0735	5.23e-06	50.4	COG0514@1|root,COG0608@1|root,COG0514@2|Bacteria,COG0608@2|Bacteria,2IK2U@201174|Actinobacteria,4CUF5@84998|Coriobacteriia	84998|Coriobacteriia	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,DHH,DHHA1,Helicase_C
k59_1225579_2	349124.Hhal_1758	2.95e-40	142.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1WXDH@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_226937_1	883.DvMF_1858	2.59e-20	95.5	COG0784@1|root,COG2202@1|root,COG2984@1|root,COG3852@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2984@2|Bacteria,COG3852@2|Bacteria,1NC9X@1224|Proteobacteria,43BKK@68525|delta/epsilon subdivisions,2X6YN@28221|Deltaproteobacteria,2MH90@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg
k59_873690_1	634176.NT05HA_1491	9.39e-73	226.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1Y73F@135625|Pasteurellales	135625|Pasteurellales	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_873690_2	765913.ThidrDRAFT_0184	1.69e-19	82.8	COG2921@1|root,COG2921@2|Bacteria,1RGV5@1224|Proteobacteria,1S61Y@1236|Gammaproteobacteria,1WZ34@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0250 family	-	-	-	ko:K09158	-	-	-	-	ko00000	-	-	-	DUF493
k59_755911_1	1278073.MYSTI_07110	2.17e-14	79.0	COG4206@1|root,COG4206@2|Bacteria,1QX9A@1224|Proteobacteria	1224|Proteobacteria	H	Carboxypeptidase regulatory-like domain	oar1	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
k59_1577106_1	948106.AWZT01000002_gene6248	1.13e-94	290.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2VHR6@28216|Betaproteobacteria,1K0DA@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
k59_1159952_2	313589.JNB_00225	4.63e-89	290.0	COG3591@1|root,COG4249@1|root,COG3591@2|Bacteria,COG4249@2|Bacteria,2IN77@201174|Actinobacteria,4FI7M@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the peptidase S1B family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
k59_873708_1	1487953.JMKF01000025_gene2357	4.7e-114	331.0	COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria,1H72I@1150|Oscillatoriales	1117|Cyanobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_226955_1	1385520.N802_07625	6.36e-62	201.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,4FEDF@85021|Intrasporangiaceae	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	appD	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_226955_2	1043205.AFYF01000058_gene2484	6.28e-10	58.5	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,4FFE5@85021|Intrasporangiaceae	201174|Actinobacteria	EP	ABC transporter (Permease)	appCC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_1577114_1	765912.Thimo_2949	3.67e-23	103.0	28IUD@1|root,2Z8T4@2|Bacteria,1QZHS@1224|Proteobacteria,1RNTX@1236|Gammaproteobacteria,1WW4J@135613|Chromatiales	135613|Chromatiales	S	Carboxysome shell peptide mid-region	-	-	-	-	-	-	-	-	-	-	-	-	CsoS2_M
k59_1400541_1	656024.FsymDg_2286	1.5e-171	500.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,2GYM5@201174|Actinobacteria,4ESXF@85013|Frankiales	201174|Actinobacteria	C	NADH dehydrogenase (ubiquinone), 30 kDa subunit	hycE	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
k59_1400541_2	1123024.AUII01000004_gene1540	2.01e-27	114.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria,4E0EJ@85010|Pseudonocardiales	201174|Actinobacteria	CP	Proton-conducting membrane transporter	hycQ	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
k59_755941_1	305700.B447_03678	7.28e-49	160.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2VIQP@28216|Betaproteobacteria,2KUR2@206389|Rhodocyclales	206389|Rhodocyclales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
k59_1635142_1	1121440.AUMA01000003_gene2893	2.16e-87	268.0	COG0492@1|root,COG0492@2|Bacteria,1R82E@1224|Proteobacteria,42PSM@68525|delta/epsilon subdivisions,2WJYX@28221|Deltaproteobacteria,2M8GU@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
k59_1635142_2	338963.Pcar_2013	3.71e-11	65.1	COG3481@1|root,COG3481@2|Bacteria,1NH0C@1224|Proteobacteria,42Q7X@68525|delta/epsilon subdivisions,2WJW2@28221|Deltaproteobacteria,43T29@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	nucleic acid binding OB-fold tRNA helicase-type	yhaM	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
k59_873736_2	105559.Nwat_2146	5.18e-98	288.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,1WW32@135613|Chromatiales	135613|Chromatiales	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_577441_2	713586.KB900536_gene1938	1.99e-22	97.4	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,NB-ARC,cNMP_binding
k59_873754_1	1218076.BAYB01000024_gene4283	5.02e-23	102.0	2DB7S@1|root,2Z7NB@2|Bacteria,1R5PS@1224|Proteobacteria,2VTNB@28216|Betaproteobacteria,1K7FK@119060|Burkholderiaceae	28216|Betaproteobacteria	S	lipopolysaccharide core region biosynthetic process	-	-	-	ko:K12981	ko00540,map00540	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01005	-	GT73	-	-
k59_1695958_2	1283300.ATXB01000002_gene2887	5.24e-73	232.0	COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria,1RZUI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	cytochrome C family protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Paired_CXXCH_1
k59_1159994_1	1267005.KB911256_gene1484	1.7e-70	218.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2U75U@28211|Alphaproteobacteria,3N7CK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_804547_1	1123514.KB905900_gene2216	6.71e-17	75.1	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,4618M@72273|Thiotrichales	72273|Thiotrichales	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
k59_804547_2	349124.Hhal_0969	1.35e-51	182.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales	135613|Chromatiales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_696353_1	583355.Caka_2045	2.79e-63	226.0	COG0771@1|root,COG2911@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	murD	-	3.4.21.10,6.3.2.13,6.3.2.9	ko:K01317,ko:K01925,ko:K01928,ko:K01932	ko00300,ko00471,ko00550,ko01100,map00300,map00471,map00550,map01100	-	R02783,R02788	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01002,ko01011,ko04131	-	-	-	DUF1727,Mur_ligase_C,Mur_ligase_M
k59_169015_1	1521187.JPIM01000142_gene2782	2.15e-105	323.0	COG1053@1|root,COG1053@2|Bacteria,2G5YB@200795|Chloroflexi,374WX@32061|Chloroflexia	32061|Chloroflexia	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1225682_1	1229780.BN381_110032	5.92e-18	82.8	COG0157@1|root,COG0157@2|Bacteria,2GV9P@201174|Actinobacteria,3UWIJ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Quinolinate phosphoribosyl transferase, N-terminal domain	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
k59_1225682_2	68170.KL590553_gene5104	1.61e-07	53.9	COG1597@1|root,COG1597@2|Bacteria,2GNNM@201174|Actinobacteria,4E66K@85010|Pseudonocardiales	201174|Actinobacteria	G	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
k59_696359_1	1449351.RISW2_10800	1.42e-99	305.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,4KKKQ@93682|Roseivivax	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1046607_1	367299.JOEE01000009_gene244	6.99e-89	268.0	COG2137@1|root,COG2137@2|Bacteria,2GMRF@201174|Actinobacteria,4FGQS@85021|Intrasporangiaceae	201174|Actinobacteria	S	Modulates RecA activity	recX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
k59_636474_1	1040983.AXAE01000018_gene5959	2.33e-76	246.0	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,2TQPC@28211|Alphaproteobacteria	1224|Proteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_29,rve
k59_755986_1	1504672.669787479	2.12e-71	231.0	COG0189@1|root,COG0189@2|Bacteria,1RI0H@1224|Proteobacteria,2W1S9@28216|Betaproteobacteria,4AH14@80864|Comamonadaceae	28216|Betaproteobacteria	HJ	COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1752207_1	95619.PM1_0228985	2.33e-105	330.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_344485_1	1123261.AXDW01000001_gene1231	3.57e-18	82.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,1X3VV@135614|Xanthomonadales	135614|Xanthomonadales	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
k59_344485_2	631362.Thi970DRAFT_00541	5.99e-27	105.0	COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,1SD3P@1236|Gammaproteobacteria,1WZFD@135613|Chromatiales	135613|Chromatiales	U	PFAM Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
k59_804565_1	1047013.AQSP01000114_gene707	5.81e-24	93.6	COG2026@1|root,COG2026@2|Bacteria	2|Bacteria	DJ	nuclease activity	relE	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0006139,GO:0006355,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0034655,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045934,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
k59_169029_1	983917.RGE_09290	7.81e-82	261.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,1KKBE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	ABC transporter	atm1	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_344492_1	870187.Thini_2375	3.72e-50	160.0	COG3411@1|root,COG3411@2|Bacteria,1MZR4@1224|Proteobacteria,1S8U3@1236|Gammaproteobacteria,461G4@72273|Thiotrichales	72273|Thiotrichales	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
k59_518005_1	153496.JNAB01000017_gene613	1.78e-11	68.9	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2TVQD@28211|Alphaproteobacteria,2JS3R@204441|Rhodospirillales	204441|Rhodospirillales	M	peptidylprolyl isomerase	ppiC	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
k59_1460697_1	592316.Pat9b_3689	3.02e-53	174.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria,3VY0T@53335|Pantoea	1236|Gammaproteobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
k59_577473_2	589865.DaAHT2_2121	3.41e-124	373.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,42MV3@68525|delta/epsilon subdivisions,2WJZB@28221|Deltaproteobacteria,2MHKM@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM ATP-dependent DNA helicase, RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind,UvrD-helicase,UvrD_C
k59_344498_1	402881.Plav_0277	3.73e-36	129.0	COG0662@1|root,COG1476@1|root,COG0662@2|Bacteria,COG1476@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	puuR	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3,HTH_31
k59_804579_1	864073.HFRIS_007631	6.01e-40	142.0	COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2VMEV@28216|Betaproteobacteria,47249@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1225728_1	278957.ABEA03000013_gene2636	7.22e-86	266.0	COG0045@1|root,COG0045@2|Bacteria,46TDG@74201|Verrucomicrobia,3K7AB@414999|Opitutae	414999|Opitutae	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_1460716_1	880072.Desac_2728	4.75e-46	154.0	arCOG10385@1|root,32SEM@2|Bacteria,1N1IG@1224|Proteobacteria,42TMW@68525|delta/epsilon subdivisions,2WQBW@28221|Deltaproteobacteria,2MRWB@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	dsrJ	-	-	-	-	-	-	-	-	-	-	-	-
k59_1460716_2	1121403.AUCV01000004_gene2024	0.000793	43.1	COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,42MNU@68525|delta/epsilon subdivisions,2WJRG@28221|Deltaproteobacteria,2MIME@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	dsrO	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_4
k59_1460718_1	768671.ThimaDRAFT_1325	5.31e-90	277.0	COG1249@1|root,COG1249@2|Bacteria,1MXQ3@1224|Proteobacteria,1RQ44@1236|Gammaproteobacteria,1X080@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1460718_2	765911.Thivi_0726	2.61e-14	73.6	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1WWGT@135613|Chromatiales	135613|Chromatiales	S	Permease YjgP YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_169091_1	246200.SPO3036	1.01e-100	311.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria,4ND2Q@97050|Ruegeria	28211|Alphaproteobacteria	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_804612_1	1454010.JEOE01000001_gene726	3.1e-191	544.0	COG1160@1|root,COG1160@2|Bacteria,2GJ8J@201174|Actinobacteria,4F0WJ@85016|Cellulomonadaceae	201174|Actinobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	Cytidylate_kin,KH_dom-like,MMR_HSR1
k59_1635275_1	566461.SSFG_04111	9.21e-16	73.2	COG4274@1|root,COG4274@2|Bacteria,2IJ0R@201174|Actinobacteria	201174|Actinobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
k59_1635275_2	1380347.JNII01000008_gene4336	9.19e-17	79.3	COG2141@1|root,COG2141@2|Bacteria,2GM7W@201174|Actinobacteria,4ERJD@85013|Frankiales	201174|Actinobacteria	C	PFAM Luciferase-like	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1160071_2	1168034.FH5T_02985	6.5e-48	157.0	COG0824@1|root,COG0824@2|Bacteria,4NSJR@976|Bacteroidetes,2FS2E@200643|Bacteroidia	976|Bacteroidetes	S	acyl-CoA thioester hydrolase, YbgC YbaW family	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
k59_228799_1	314285.KT71_18052	7.64e-44	147.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria	1224|Proteobacteria	E	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
k59_346193_2	420662.Mpe_A1369	6.54e-27	105.0	COG2354@1|root,COG2354@2|Bacteria,1MVYU@1224|Proteobacteria,2VHTU@28216|Betaproteobacteria,1KJK3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF808)	yedI	-	-	ko:K09781	-	-	-	-	ko00000	-	-	-	DUF808
k59_1048763_1	485915.Dret_1585	5.87e-08	58.5	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,42PHP@68525|delta/epsilon subdivisions,2WIXN@28221|Deltaproteobacteria,2M8D8@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	PFAM WD40 domain protein beta Propeller	tolB	GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_1579244_1	383372.Rcas_3795	3.6e-79	246.0	COG0309@1|root,COG0309@2|Bacteria,2G5MV@200795|Chloroflexi,376G0@32061|Chloroflexia	32061|Chloroflexia	O	TIGRFAM hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
k59_1048786_1	756067.MicvaDRAFT_4927	1.77e-31	132.0	COG0515@1|root,COG0642@1|root,COG2199@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales	1117|Cyanobacteria	KLT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,HATPase_c,HisKA,Pkinase,Response_reg
k59_1697972_1	1499686.BN1079_00691	4.27e-73	231.0	COG3594@1|root,COG3594@2|Bacteria,1QV1G@1224|Proteobacteria,1S232@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	COG3594 Fucose 4-O-acetylase and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_1579261_1	1121937.AUHJ01000044_gene1205	1.58e-129	381.0	COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,1SU06@1236|Gammaproteobacteria,46D8H@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_1402640_1	1397528.Q671_11745	7.71e-27	112.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1XHUC@135619|Oceanospirillales	135619|Oceanospirillales	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_1402655_1	29730.Gorai.012G005900.1	4e-07	51.6	COG0578@1|root,KOG0042@2759|Eukaryota,37QJA@33090|Viridiplantae,3G95W@35493|Streptophyta	35493|Streptophyta	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	-	GO:0003674,GO:0003824,GO:0004368,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005975,GO:0006066,GO:0006071,GO:0006072,GO:0006091,GO:0006116,GO:0006127,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009117,GO:0009987,GO:0015980,GO:0016052,GO:0016491,GO:0016614,GO:0016901,GO:0019362,GO:0019400,GO:0019405,GO:0019563,GO:0019637,GO:0019674,GO:0019751,GO:0022900,GO:0022904,GO:0034308,GO:0034641,GO:0042180,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046164,GO:0046174,GO:0046483,GO:0046496,GO:0051186,GO:0052646,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575,GO:1901615,GO:1901616	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
k59_1402655_2	1286631.X805_27720	3.32e-59	186.0	COG3386@1|root,COG3386@2|Bacteria,1MWTR@1224|Proteobacteria,2VMAD@28216|Betaproteobacteria,1KJBD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	SMP-30 Gluconolaconase	-	-	3.1.1.15	ko:K13874,ko:K14274	ko00040,ko00053,ko01100,map00040,map00053,map01100	-	R02427,R02526	RC00537,RC00713	ko00000,ko00001,ko01000	-	-	-	SGL
k59_1048827_1	1123065.ATWL01000005_gene1275	7.92e-55	181.0	COG0708@1|root,COG0708@2|Bacteria,2GKIS@201174|Actinobacteria	201174|Actinobacteria	L	exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_1174883_2	572477.Alvin_1022	7.36e-28	106.0	COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,1S8VU@1236|Gammaproteobacteria,1WYI6@135613|Chromatiales	135613|Chromatiales	J	Belongs to the HSP15 family	-	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
k59_1585713_1	1095767.CAHD01000213_gene631	7.9e-77	247.0	COG0392@1|root,COG0392@2|Bacteria,2GMAV@201174|Actinobacteria,4F0KN@85016|Cellulomonadaceae	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
k59_587809_1	351016.RAZWK3B_01270	1.84e-89	274.0	COG1910@1|root,COG1910@2|Bacteria,1MVS4@1224|Proteobacteria,2TU96@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG1910, Periplasmic molybdate-binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,PBP_like
k59_940733_1	1283300.ATXB01000001_gene2122	5.36e-36	129.0	COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,1S3S0@1236|Gammaproteobacteria,1XF1T@135618|Methylococcales	135618|Methylococcales	NU	PFAM Fimbrial assembly	-	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
k59_940733_2	765913.ThidrDRAFT_3460	1.24e-31	117.0	COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1WXKR@135613|Chromatiales	135613|Chromatiales	NU	Pilus assembly protein PilO	-	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
k59_470364_1	1437882.AZRU01000004_gene1866	1.88e-23	103.0	COG2925@1|root,COG2925@2|Bacteria,1MV0U@1224|Proteobacteria,1RM85@1236|Gammaproteobacteria,1YE5G@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	L	Exonuclease C-terminal	sbcB	GO:0000175,GO:0000287,GO:0000738,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008852,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016829,GO:0016835,GO:0016895,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0046872,GO:0051575,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575	3.1.11.1	ko:K01141	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_X-T_C,RNase_T
k59_1585714_1	1122621.ATZA01000026_gene2212	4.47e-26	110.0	COG1044@1|root,COG1044@2|Bacteria,4NE5G@976|Bacteroidetes,1IP38@117747|Sphingobacteriia	976|Bacteroidetes	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
k59_1057581_1	367299.JOEE01000003_gene3054	2.41e-183	524.0	COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4FFCM@85021|Intrasporangiaceae	201174|Actinobacteria	I	carboxylase	bccA	-	6.3.4.14,6.4.1.2,6.4.1.3	ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04385	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_705277_1	460265.Mnod_6087	2.76e-26	105.0	COG2070@1|root,COG2070@2|Bacteria,1MU0U@1224|Proteobacteria,2TS5U@28211|Alphaproteobacteria,1JTR5@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM 2-nitropropane dioxygenase NPD	MA20_20575	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
k59_705277_2	398527.Bphyt_1392	8.82e-42	145.0	COG0667@1|root,COG0667@2|Bacteria,1MU1S@1224|Proteobacteria,2VMYU@28216|Betaproteobacteria,1K2AM@119060|Burkholderiaceae	28216|Betaproteobacteria	C	aldo keto reductase	-	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
k59_235729_1	472759.Nhal_1938	8.5e-10	60.5	COG3211@1|root,COG3211@2|Bacteria,1R7E2@1224|Proteobacteria,1SCSQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Bacterial protein of unknown function (DUF839)	-	-	-	ko:K07093	-	-	-	-	ko00000	-	-	-	DUF839
k59_1703210_1	76114.ebA7121	1.54e-05	45.4	COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,2WGT1@28216|Betaproteobacteria,2KWSX@206389|Rhodocyclales	206389|Rhodocyclales	T	Signal transduction protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_1703210_2	1370122.JHXQ01000023_gene3019	6.64e-90	284.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,4B76T@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	gamma-glutamyltransferase	ggt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1585724_1	335543.Sfum_1380	5.62e-87	267.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,2MQ94@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_60167_1	1177179.A11A3_11558	3.96e-63	200.0	COG3063@1|root,COG3063@2|Bacteria,1RD9T@1224|Proteobacteria,1S3R3@1236|Gammaproteobacteria,1XJZS@135619|Oceanospirillales	135619|Oceanospirillales	NU	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TAtT,TPR_8
k59_646583_1	1036674.A28LD_1048	0.000422	41.6	COG5660@1|root,COG5660@2|Bacteria,1PCBF@1224|Proteobacteria,1SX8W@1236|Gammaproteobacteria,2QH0F@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
k59_646583_2	493475.GARC_4186	2.15e-40	136.0	COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,1S62I@1236|Gammaproteobacteria,467E8@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
k59_1351003_1	95619.PM1_0202965	2.66e-51	175.0	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,1RN4G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Glycolate oxidase	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1351003_2	314278.NB231_02895	4.35e-60	198.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1WVW1@135613|Chromatiales	135613|Chromatiales	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7,Fer4_8
k59_822739_1	1317118.ATO8_04576	4.52e-19	82.4	2E7WC@1|root,2ZYAB@2|Bacteria,1PKSF@1224|Proteobacteria,2UZE2@28211|Alphaproteobacteria,4KP1V@93682|Roseivivax	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_822739_2	765910.MARPU_15600	3.35e-29	110.0	COG0515@1|root,COG0515@2|Bacteria,1NDP8@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_763968_2	1122137.AQXF01000002_gene449	6.87e-12	67.4	COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,2TTXE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glyoxalase	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
k59_118246_1	595460.RRSWK_03255	2.2e-68	224.0	COG0488@1|root,COG0488@2|Bacteria,2IWXR@203682|Planctomycetes	203682|Planctomycetes	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
k59_1468450_1	867903.ThesuDRAFT_01696	3.68e-05	47.0	COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,3WCC5@538999|Clostridiales incertae sedis	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_1468450_2	986075.CathTA2_0516	6.17e-39	133.0	COG0292@1|root,COG0292@2|Bacteria,1V6DB@1239|Firmicutes,4HH2W@91061|Bacilli	91061|Bacilli	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
k59_470386_1	880072.Desac_0816	1.08e-77	244.0	COG0247@1|root,COG0247@2|Bacteria,1N5Q2@1224|Proteobacteria,42P5D@68525|delta/epsilon subdivisions,2WJ9I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Cysteine-rich	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17
k59_60187_1	1123065.ATWL01000017_gene2039	5.63e-69	212.0	COG0359@1|root,COG0359@2|Bacteria,2IKX7@201174|Actinobacteria	201174|Actinobacteria	J	Binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
k59_60187_2	471853.Bcav_4176	2.35e-36	134.0	COG0534@1|root,COG0534@2|Bacteria,2GJE3@201174|Actinobacteria	201174|Actinobacteria	V	MATE efflux family protein	dinF	-	-	-	-	-	-	-	-	-	-	-	MatE
k59_118249_1	1211114.ALIP01000016_gene2807	1.71e-79	263.0	COG4258@1|root,COG4258@2|Bacteria,1MU1E@1224|Proteobacteria,1RMP8@1236|Gammaproteobacteria,1X5EV@135614|Xanthomonadales	135614|Xanthomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	MMPL
k59_763977_1	1123360.thalar_00077	5.08e-59	187.0	COG5592@1|root,COG5592@2|Bacteria,1RGUY@1224|Proteobacteria,2UD7B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Hemerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
k59_883507_1	1049564.TevJSym_aa01810	2.57e-288	803.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J8SM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Citrate transporter	sac1	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_1294417_1	1116472.MGMO_105c00220	2.31e-29	115.0	COG0484@1|root,COG0484@2|Bacteria,1P02E@1224|Proteobacteria	1224|Proteobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
k59_883511_1	338969.Rfer_3775	6.01e-16	76.6	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_883511_2	543913.D521_0143	2.68e-48	163.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2VJ1W@28216|Betaproteobacteria,1KPSD@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_706305_1	1484460.JSWG01000008_gene1990	3.19e-75	240.0	COG0446@1|root,COG0446@2|Bacteria,4NEK6@976|Bacteroidetes,1HZW9@117743|Flavobacteriia	976|Bacteroidetes	S	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_588902_1	1123392.AQWL01000002_gene1903	9.04e-35	124.0	COG1416@1|root,COG1416@2|Bacteria,1RE8C@1224|Proteobacteria,2VV8B@28216|Betaproteobacteria,1KT2D@119069|Hydrogenophilales	119069|Hydrogenophilales	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
k59_1117141_1	1123368.AUIS01000019_gene1205	1.13e-08	55.1	COG3608@1|root,COG3608@2|Bacteria,1R784@1224|Proteobacteria,1RRY6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM Succinylglutamate desuccinylase Aspartoacylase	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
k59_1117141_2	1211112.ALJC01000110_gene2855	3.15e-36	132.0	COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	cpdA	GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005488,GO:0005506,GO:0008081,GO:0008150,GO:0008198,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0042545,GO:0042578,GO:0043167,GO:0043169,GO:0045229,GO:0046872,GO:0046914,GO:0071554,GO:0071555,GO:0071840	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos
k59_588913_1	1123393.KB891316_gene1128	1.74e-71	216.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2VQEB@28216|Betaproteobacteria,1KS4V@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_588913_2	1123393.KB891316_gene1127	5.45e-22	89.0	COG1416@1|root,COG1416@2|Bacteria,1RHW0@1224|Proteobacteria,2VWXN@28216|Betaproteobacteria,1KSFB@119069|Hydrogenophilales	119069|Hydrogenophilales	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
k59_1058751_1	762376.AXYL_00943	3.19e-68	232.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,3T1BB@506|Alcaligenaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_471459_1	1260251.SPISAL_00265	2.51e-40	140.0	COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1WYZ6@135613|Chromatiales	135613|Chromatiales	S	Belongs to the Smg family	smg	-	-	ko:K03747	-	-	-	-	ko00000	-	-	-	DUF494
k59_471459_2	1122604.JONR01000010_gene3988	6.45e-10	62.4	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1X2Y5@135614|Xanthomonadales	135614|Xanthomonadales	LU	DNA processing protein DprA	smf	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_1762854_1	590998.Celf_3583	2.71e-08	55.5	COG0640@1|root,COG0640@2|Bacteria,2IQ55@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
k59_236963_1	765914.ThisiDRAFT_2542	1.19e-13	73.9	COG3087@1|root,COG3087@2|Bacteria,1MYFG@1224|Proteobacteria,1SD3J@1236|Gammaproteobacteria,1WYSZ@135613|Chromatiales	135613|Chromatiales	D	PFAM Sporulation	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
k59_236963_2	765911.Thivi_3794	9.45e-46	163.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales	135613|Chromatiales	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_588922_1	290397.Adeh_3163	1.28e-35	139.0	2F2IM@1|root,33VFK@2|Bacteria,1RIX8@1224|Proteobacteria,42T5Z@68525|delta/epsilon subdivisions,2WPA9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
k59_1528007_2	1049564.TevJSym_ap00180	1.26e-14	77.8	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,1RPDY@1236|Gammaproteobacteria,1J6T8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	cpxA	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007155,GO:0007165,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0022610,GO:0023014,GO:0023052,GO:0031224,GO:0031589,GO:0035556,GO:0036211,GO:0042710,GO:0042802,GO:0043170,GO:0043412,GO:0043708,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044464,GO:0044764,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0090605,GO:0140096,GO:1901564	2.7.13.3	ko:K07640	ko01503,ko02020,map01503,map02020	M00447,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	CpxA_peri,HAMP,HATPase_c,HisKA
k59_295376_1	471856.Jden_2553	1.21e-53	179.0	COG0357@1|root,COG0357@2|Bacteria,2GM9Z@201174|Actinobacteria	201174|Actinobacteria	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
k59_883547_1	1173024.KI912149_gene6429	4.57e-33	134.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G24Y@1117|Cyanobacteria,1JJZM@1189|Stigonemataceae	1117|Cyanobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
k59_355127_1	1380391.JIAS01000011_gene4760	3.97e-102	306.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2JPVQ@204441|Rhodospirillales	204441|Rhodospirillales	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	-	ko:K11076	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	ABC_tran,TOBE_2
k59_1058766_1	33876.JNXY01000061_gene9532	6.79e-06	53.5	COG0179@1|root,COG0179@2|Bacteria,2H25J@201174|Actinobacteria,4DH6Z@85008|Micromonosporales	201174|Actinobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
k59_942284_1	1048339.KB913029_gene4582	2.31e-64	215.0	COG0768@1|root,COG0768@2|Bacteria,2GKHH@201174|Actinobacteria,4ERN7@85013|Frankiales	201174|Actinobacteria	M	Penicillin-binding protein, dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
k59_1645757_1	405948.SACE_5073	2.99e-126	372.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4E9CU@85010|Pseudonocardiales	201174|Actinobacteria	L	Transposase	tnp3508a	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_1528010_2	1121935.AQXX01000142_gene2166	8.91e-78	240.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,1XH47@135619|Oceanospirillales	135619|Oceanospirillales	IQ	reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_119330_1	1237149.C900_05651	7.01e-42	151.0	COG3547@1|root,COG3547@2|Bacteria,4NGED@976|Bacteroidetes,47NI4@768503|Cytophagia	976|Bacteroidetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_412717_1	1517416.IDAT_09075	2.38e-24	99.0	COG3216@1|root,COG3216@2|Bacteria,1N1Q6@1224|Proteobacteria,1S9HF@1236|Gammaproteobacteria,2QG2H@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2062)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2062
k59_1822748_1	1120983.KB894571_gene2517	6.79e-93	286.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,2TR0V@28211|Alphaproteobacteria,1JNQ6@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	mttB2	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
k59_764888_1	1255043.TVNIR_0080	1.79e-23	95.9	COG0500@1|root,COG2226@2|Bacteria,1RDI3@1224|Proteobacteria,1S423@1236|Gammaproteobacteria,1WWQ9@135613|Chromatiales	135613|Chromatiales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
k59_1822753_1	1166016.W5S_2588	2.61e-24	98.6	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,1MQZG@122277|Pectobacterium	1236|Gammaproteobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0034641,GO:0042364,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iECUMN_1333.ECUMN_1592	adh_short_C2
k59_1822753_2	998088.B565_1317	8.57e-09	58.5	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1Y3X8@135624|Aeromonadales	135624|Aeromonadales	M	Transglycosylase SLT domain	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_764890_1	991905.SL003B_1339	1.26e-94	288.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2TRQA@28211|Alphaproteobacteria,4BPKS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_530248_1	1090319.KE386571_gene1013	2.79e-49	174.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,2K0SB@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
k59_1586684_1	929712.KI912613_gene799	0.000465	48.9	COG0683@1|root,COG0683@2|Bacteria,2I8ME@201174|Actinobacteria,4CQWB@84995|Rubrobacteria	84995|Rubrobacteria	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_1175990_1	1286106.MPL1_01687	7.48e-66	219.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,460EP@72273|Thiotrichales	72273|Thiotrichales	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_61725_1	1123228.AUIH01000004_gene1089	4.01e-14	71.2	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,1RZDH@1236|Gammaproteobacteria,1XIX3@135619|Oceanospirillales	135619|Oceanospirillales	S	ATPase, AAA	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
k59_764900_1	396588.Tgr7_1464	1.7e-56	188.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,1WWK8@135613|Chromatiales	135613|Chromatiales	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
k59_471503_1	572477.Alvin_0834	1.15e-08	55.8	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1WWTF@135613|Chromatiales	135613|Chromatiales	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
k59_471503_2	572477.Alvin_0835	8.37e-44	144.0	COG3288@1|root,COG3288@2|Bacteria,1MZ3E@1224|Proteobacteria,1S6HX@1236|Gammaproteobacteria,1WYKC@135613|Chromatiales	135613|Chromatiales	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
k59_471503_3	1049564.TevJSym_bl00090	4.51e-77	243.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,1J5AS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_1234734_1	1167006.UWK_03288	4e-109	335.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,42M9Q@68525|delta/epsilon subdivisions,2WKKT@28221|Deltaproteobacteria,2MPSR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_1704304_1	177439.DP1968	7.68e-25	97.8	COG3584@1|root,COG3584@2|Bacteria,1NUBZ@1224|Proteobacteria,42ZKS@68525|delta/epsilon subdivisions,2WUSM@28221|Deltaproteobacteria,2MNAS@213118|Desulfobacterales	28221|Deltaproteobacteria	S	3D domain	-	-	-	-	-	-	-	-	-	-	-	-	3D
k59_1704304_2	903814.ELI_2476	3.84e-16	76.6	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia,25WPN@186806|Eubacteriaceae	186801|Clostridia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
k59_1704304_3	754436.JCM19237_1677	0.000218	43.1	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1XSDN@135623|Vibrionales	135623|Vibrionales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
k59_647669_1	335543.Sfum_2164	2.32e-89	287.0	COG1480@1|root,COG1480@2|Bacteria,1NCY5@1224|Proteobacteria,42MI9@68525|delta/epsilon subdivisions,2WJI1@28221|Deltaproteobacteria,2MR04@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	7TM-HD extracellular	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
k59_1120818_1	582744.Msip34_2279	6.15e-88	275.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2VGZ9@28216|Betaproteobacteria,2KKEY@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_1240924_1	96561.Dole_0098	9.92e-70	226.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MISJ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	ribonuclease Rne Rng family	cafA	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_69239_1	1116375.VEJY3_04050	1.46e-134	395.0	COG1680@1|root,COG1680@2|Bacteria,1MY01@1224|Proteobacteria,1RNUI@1236|Gammaproteobacteria,1XZIB@135623|Vibrionales	135623|Vibrionales	V	Beta-lactamase	-	-	3.5.2.6	ko:K01467	ko01501,ko02020,map01501,map02020	M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000	-	-	-	Beta-lactamase
k59_1065067_1	883080.HMPREF9697_03471	1.88e-55	179.0	COG0693@1|root,COG0693@2|Bacteria,1MY0C@1224|Proteobacteria,2U5BS@28211|Alphaproteobacteria,3JREZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	DJ-1/PfpI family	pfpI	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
k59_594103_1	103733.JNYO01000070_gene3625	5.51e-06	55.1	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2GM1B@201174|Actinobacteria,4DYWD@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,GerE,Trans_reg_C
k59_69246_1	289376.THEYE_A0743	1.09e-18	87.0	COG2204@1|root,COG2204@2|Bacteria,3J10B@40117|Nitrospirae	40117|Nitrospirae	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_69246_2	1123355.JHYO01000010_gene3543	8.49e-24	102.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,36X95@31993|Methylocystaceae	28211|Alphaproteobacteria	T	PAS domain	cckA	-	2.7.13.3	ko:K13587	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
k59_362733_1	1049564.TevJSym_ao00790	4e-134	394.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1J4IG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_1302132_2	1294143.H681_22215	3.95e-14	73.2	COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,1RYFC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	CBS-domain-containing membrane protein	-	-	-	ko:K07168	-	-	-	-	ko00000	-	-	-	HPP
k59_769167_1	290317.Cpha266_2628	1.75e-128	385.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
k59_828802_1	1249627.D779_2735	9.24e-92	276.0	COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,1T20F@1236|Gammaproteobacteria,1WW2D@135613|Chromatiales	135613|Chromatiales	E	PFAM Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
k59_244829_1	635013.TherJR_0913	4.81e-35	126.0	COG0518@1|root,COG0518@2|Bacteria,1UAH0@1239|Firmicutes,24DR4@186801|Clostridia,261SI@186807|Peptococcaceae	186801|Clostridia	F	PFAM Glutamine amidotransferase class-I	-	-	-	-	-	-	-	-	-	-	-	-	GATase
k59_1830281_1	870187.Thini_0399	9.09e-72	226.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,1RMNR@1236|Gammaproteobacteria,4609K@72273|Thiotrichales	72273|Thiotrichales	E	Aminotransferase class-V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_1709279_1	1121272.KB903290_gene4607	8.86e-71	223.0	COG1182@1|root,COG1182@2|Bacteria,2I9P0@201174|Actinobacteria,4DD9J@85008|Micromonosporales	201174|Actinobacteria	I	Flavodoxin-like fold	azoR	-	-	ko:K01118	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_2
k59_69253_1	56780.SYN_01628	1.69e-58	196.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria,2MR6S@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	TIGRFAM glutamine synthetase, type I	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_828805_1	530564.Psta_1819	1.12e-130	380.0	COG0560@1|root,COG0560@2|Bacteria,2IXZ0@203682|Planctomycetes	203682|Planctomycetes	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
k59_183329_1	478801.Ksed_20090	8.03e-148	457.0	COG0110@1|root,COG1020@1|root,COG2171@1|root,COG0110@2|Bacteria,COG1020@2|Bacteria,COG2171@2|Bacteria,2HF5T@201174|Actinobacteria,1ZWJE@145357|Dermacoccaceae	201174|Actinobacteria	Q	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,PP-binding
k59_1475963_1	76114.ebA1167	5e-53	188.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2VI9F@28216|Betaproteobacteria,2KUMU@206389|Rhodocyclales	206389|Rhodocyclales	H	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_535537_1	1380354.JIAN01000005_gene2550	4.24e-92	280.0	COG2896@1|root,COG2896@2|Bacteria,2GN0V@201174|Actinobacteria,4F1Q4@85016|Cellulomonadaceae	201174|Actinobacteria	H	Molybdenum Cofactor Synthesis C	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
k59_652969_1	589865.DaAHT2_2463	9.28e-83	266.0	COG5421@1|root,COG5421@2|Bacteria,1R7NE@1224|Proteobacteria,42M25@68525|delta/epsilon subdivisions,2WKHV@28221|Deltaproteobacteria,2MJVY@213118|Desulfobacterales	28221|Deltaproteobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_69266_1	1303518.CCALI_00218	1.32e-14	77.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	actE	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_769179_1	1187851.A33M_2600	2.64e-39	133.0	COG5470@1|root,COG5470@2|Bacteria,1NHS6@1224|Proteobacteria,2UMFK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
k59_769179_2	1297865.APJD01000036_gene1521	3.2e-16	78.2	COG0625@1|root,COG0625@2|Bacteria,1RA4M@1224|Proteobacteria,2TV0I@28211|Alphaproteobacteria,3JTZ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
k59_1416374_1	472175.EL18_01915	1.2e-34	129.0	COG0600@1|root,COG0600@2|Bacteria,1MU6Q@1224|Proteobacteria,2TQT6@28211|Alphaproteobacteria,43JEQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	nitrate ABC transporter	nasE	-	-	ko:K02050,ko:K15577	ko00910,ko02010,map00910,map02010	M00188,M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.16.1,3.A.1.16.2,3.A.1.17	-	-	BPD_transp_1
k59_535544_1	368407.Memar_1426	1.22e-80	255.0	COG1055@1|root,arCOG00238@2157|Archaea,2XVDU@28890|Euryarchaeota,2N961@224756|Methanomicrobia	224756|Methanomicrobia	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_535544_2	631362.Thi970DRAFT_04016	1.18e-10	61.2	COG0526@1|root,COG0526@2|Bacteria,1RJUZ@1224|Proteobacteria,1S6Y0@1236|Gammaproteobacteria,1WYNQ@135613|Chromatiales	135613|Chromatiales	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_1302162_1	522306.CAP2UW1_1455	4.39e-62	204.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VJJ7@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1240967_1	1049564.TevJSym_ak00560	2.79e-119	363.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,1J5MJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Ferrous iron transport protein B	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_1475981_1	391615.ABSJ01000026_gene114	4.49e-64	206.0	COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,1S50X@1236|Gammaproteobacteria,1J761@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
k59_1830316_1	631362.Thi970DRAFT_03314	2.52e-48	169.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1WXIB@135613|Chromatiales	135613|Chromatiales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_891022_1	880072.Desac_0214	1.38e-77	258.0	COG3280@1|root,COG3280@2|Bacteria,1QTVK@1224|Proteobacteria,42MEW@68525|delta/epsilon subdivisions,2WJX1@28221|Deltaproteobacteria,2MQXA@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	PFAM alpha amylase, catalytic	treY	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
k59_244892_1	290397.Adeh_2791	3.64e-24	102.0	COG0493@1|root,COG0543@1|root,COG1633@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,COG1633@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WKB4@28221|Deltaproteobacteria,2YTUD@29|Myxococcales	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_244892_2	1187851.A33M_4208	4.29e-95	293.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,3FCY5@34008|Rhodovulum	28211|Alphaproteobacteria	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2
k59_362783_1	1499967.BAYZ01000069_gene1853	9.92e-68	230.0	COG0474@1|root,COG0474@2|Bacteria,2NNSC@2323|unclassified Bacteria	2|Bacteria	P	Cation transporter/ATPase, N-terminus	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_1767724_1	1385935.N836_20045	1.75e-70	237.0	COG0474@1|root,COG0474@2|Bacteria,1G0JX@1117|Cyanobacteria,1H7PF@1150|Oscillatoriales	1117|Cyanobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_769202_1	472759.Nhal_3801	3.94e-61	196.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1WWCV@135613|Chromatiales	135613|Chromatiales	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_1651215_1	1141662.OOA_03244	9.2e-54	177.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,1RMK2@1236|Gammaproteobacteria,3Z74W@586|Providencia	1236|Gammaproteobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_1591617_1	1122602.ATXP01000004_gene1821	1.79e-39	146.0	COG2308@1|root,COG2308@2|Bacteria,2GN0J@201174|Actinobacteria,1W7QA@1268|Micrococcaceae	201174|Actinobacteria	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_1,CP_ATPgrasp_2
k59_1591617_2	446466.Cfla_2220	6.81e-146	419.0	COG2307@1|root,COG2307@2|Bacteria,2GN0T@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
k59_1591617_3	1095767.CAHD01000186_gene144	1.43e-118	348.0	COG1305@1|root,COG1305@2|Bacteria,2GN5D@201174|Actinobacteria	201174|Actinobacteria	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_244935_1	1163617.SCD_n01952	2.93e-49	165.0	COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria	1224|Proteobacteria	P	part of a sulfur-relay system	tusE	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_711674_1	471853.Bcav_2059	3.12e-10	60.8	2EUQS@1|root,33N6D@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_711674_2	471853.Bcav_2058	5.9e-40	144.0	COG2378@1|root,COG2378@2|Bacteria,2GMAU@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	pafC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
k59_69324_1	1249627.D779_1514	8.96e-75	250.0	COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1WXKG@135613|Chromatiales	135613|Chromatiales	DM	mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM,MscS_porin
k59_891054_1	1123065.ATWL01000008_gene2472	8.84e-103	307.0	COG0498@1|root,COG0498@2|Bacteria,2GJ5F@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_891054_2	446466.Cfla_1057	2.9e-78	244.0	COG0083@1|root,COG0083@2|Bacteria,2GKIW@201174|Actinobacteria,4F0RU@85016|Cellulomonadaceae	201174|Actinobacteria	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_1476035_1	1095767.CAHD01000148_gene2010	3.62e-71	239.0	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,4F0TJ@85016|Cellulomonadaceae	201174|Actinobacteria	S	Uncharacterised protein family (UPF0182)	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_69327_1	861299.J421_2655	1.41e-93	281.0	COG0825@1|root,COG0825@2|Bacteria,1ZSW6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
k59_950031_1	909663.KI867150_gene490	7.48e-87	271.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,42N2B@68525|delta/epsilon subdivisions,2WJS9@28221|Deltaproteobacteria,2MQ4E@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Vacuole effluxer Atg22 like	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_1302211_1	377629.TERTU_2472	4.08e-40	139.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1RNU8@1236|Gammaproteobacteria,2PN6D@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	J	Telomere recombination	yciO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
k59_1302211_2	1116472.MGMO_53c00370	2.79e-56	182.0	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,1S4N8@1236|Gammaproteobacteria,1XE0T@135618|Methylococcales	135618|Methylococcales	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1004157_1	304371.MCP_1923	4.55e-64	207.0	COG2801@1|root,arCOG10339@2157|Archaea	2157|Archaea	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_1357261_1	948565.AFFP02000025_gene84	5.19e-24	100.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1Y7IZ@135625|Pasteurellales	135625|Pasteurellales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_1121511_1	670307.HYPDE_28623	3.37e-08	53.5	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TSX9@28211|Alphaproteobacteria,3N6CA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	BQ	histone deacetylase	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
k59_1121511_2	670307.HYPDE_28618	1.84e-161	457.0	COG1028@1|root,COG1028@2|Bacteria,1MUSQ@1224|Proteobacteria,2TTJC@28211|Alphaproteobacteria,3N844@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	-	-	ko:K13775	ko00281,map00281	-	R08087,R08096,R10125,R10126	RC00080,RC00087	ko00000,ko00001	-	-	-	adh_short,adh_short_C2
k59_1065208_1	1123253.AUBD01000002_gene1275	7.33e-27	112.0	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,1X4M7@135614|Xanthomonadales	135614|Xanthomonadales	I	Belongs to the GPAT DAPAT family	plsB	-	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_1065208_2	1245471.PCA10_25370	6.05e-12	69.3	COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,1RPY8@1236|Gammaproteobacteria,1YE2V@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Protein of unknown function (DUF1302)	gbt	-	-	-	-	-	-	-	-	-	-	-	DUF1302
k59_1830368_2	1255043.TVNIR_1957	9.16e-33	117.0	COG0838@1|root,COG0838@2|Bacteria	2|Bacteria	C	NADH dehydrogenase (ubiquinone) activity	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_594171_1	382464.ABSI01000006_gene815	3.15e-20	95.5	COG0771@1|root,COG2911@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,46UDY@74201|Verrucomicrobia,2IWGN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	Q	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1302231_1	335543.Sfum_2716	3.08e-77	244.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,42N63@68525|delta/epsilon subdivisions,2WJPA@28221|Deltaproteobacteria,2MQRM@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM nickel-dependent hydrogenase, large subunit	hoxL	-	1.12.1.2,1.8.98.5	ko:K00436,ko:K14126	ko00680,map00680	-	R00019,R00700,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_1065242_1	768671.ThimaDRAFT_3258	8.43e-17	77.8	COG2258@1|root,COG2258@2|Bacteria,1PVVI@1224|Proteobacteria,1SB64@1236|Gammaproteobacteria,1X0QQ@135613|Chromatiales	135613|Chromatiales	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
k59_535603_1	1267005.KB911259_gene4020	6.84e-267	739.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2TR2C@28211|Alphaproteobacteria,3N7QH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	ccoN	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_535603_2	509190.Cseg_1884	1.96e-44	150.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2TRGW@28211|Alphaproteobacteria,2KFH7@204458|Caulobacterales	204458|Caulobacterales	C	TIGRFAM cytochrome c oxidase, cbb3-type, subunit II	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
k59_653042_1	521719.ATXQ01000003_gene2231	5.55e-31	120.0	COG1668@1|root,COG1668@2|Bacteria,1NUA9@1224|Proteobacteria	1224|Proteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_653042_2	177437.HRM2_03740	1.78e-53	173.0	COG1131@1|root,COG1131@2|Bacteria,1MXHE@1224|Proteobacteria,42PFF@68525|delta/epsilon subdivisions	1224|Proteobacteria	V	ABC transporter, ATP-binding protein	nosF	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1591651_1	768671.ThimaDRAFT_3250	9.76e-27	113.0	COG1208@1|root,COG2148@1|root,COG1208@2|Bacteria,COG2148@2|Bacteria,1MYXF@1224|Proteobacteria,1S89K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,NTP_transferase
k59_1241063_1	314278.NB231_06156	1.41e-17	82.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1WWYN@135613|Chromatiales	135613|Chromatiales	U	type IV pilus secretin PilQ	-	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_1241063_2	322710.Avin_45250	4.68e-61	192.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
k59_1181447_1	177439.DP1202	3.64e-161	469.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,2MHX9@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_246674_1	35754.JNYJ01000077_gene7814	1.53e-28	109.0	COG1846@1|root,COG1846@2|Bacteria,2IKZU@201174|Actinobacteria,4DF2P@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
k59_184306_1	381666.H16_A0118	2.42e-12	69.3	COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,2VPN6@28216|Betaproteobacteria,1K22Q@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function, DUF484	-	-	-	ko:K09921	-	-	-	-	ko00000	-	-	-	DUF484
k59_184306_2	557598.LHK_01856	0.000184	42.7	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2VI0C@28216|Betaproteobacteria,2KQ16@206351|Neisseriales	206351|Neisseriales	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
k59_1066831_1	408672.NBCG_02518	7.42e-101	315.0	COG3345@1|root,COG3345@2|Bacteria,2GJJ1@201174|Actinobacteria,4DSZC@85009|Propionibacteriales	201174|Actinobacteria	G	Glycosyl hydrolase family 36 N-terminal domain	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
k59_23105_2	1026882.MAMP_02476	5.53e-37	139.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,460T9@72273|Thiotrichales	72273|Thiotrichales	M	PFAM Surface antigen	-	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,POTRA_TamA_1
k59_542373_1	1454004.AW11_02484	1.34e-48	161.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_542373_2	349106.PsycPRwf_2093	3.4e-14	71.6	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	phosphate regulon transcriptional regulatory protein PhoB	phoB	GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0043254,GO:0044087,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1250790_1	1121405.dsmv_0890	2.14e-77	246.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42MF0@68525|delta/epsilon subdivisions,2WMC1@28221|Deltaproteobacteria,2MIDP@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase for insertion sequences IS1326 IS1353 (IS21 IS408 IS1162 family protein)	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1188698_1	1304865.JAGF01000001_gene1993	9.68e-46	163.0	COG1299@1|root,COG1445@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,2GJU4@201174|Actinobacteria	201174|Actinobacteria	GT	Phosphotransferase System	fruA	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2,PTS_EIIC,PTS_IIB
k59_1715929_1	1121403.AUCV01000065_gene4167	1.5e-156	452.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2MIW3@213118|Desulfobacterales	2|Bacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_1539975_1	1121127.JAFA01000006_gene5456	3.73e-95	299.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,1K4XH@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1539975_2	1121127.JAFA01000006_gene5457	1.59e-14	70.9	COG3427@1|root,COG3427@2|Bacteria,1N4EQ@1224|Proteobacteria,2W4Q9@28216|Betaproteobacteria,1K52T@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Carbon monoxide dehydrogenase subunit G (CoxG)	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
k59_1598319_1	765913.ThidrDRAFT_3870	2.39e-88	278.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1WX9W@135613|Chromatiales	135613|Chromatiales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
k59_78838_1	543632.JOJL01000055_gene248	1.13e-70	231.0	COG1032@1|root,COG1032@2|Bacteria,2GJY1@201174|Actinobacteria,4DA3H@85008|Micromonosporales	201174|Actinobacteria	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_78838_2	935866.JAER01000034_gene3634	1.98e-27	110.0	COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,4DN3V@85009|Propionibacteriales	201174|Actinobacteria	D	Cell cycle protein	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_660289_1	1385519.N801_08620	0.000968	40.4	2CCBI@1|root,32RVA@2|Bacteria,2IFX8@201174|Actinobacteria,4FI0D@85021|Intrasporangiaceae	201174|Actinobacteria	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
k59_660289_2	1463920.JOGB01000014_gene5853	3.88e-74	233.0	COG1652@1|root,COG1652@2|Bacteria,2IAAU@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Peptidoglycan-binding	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_542385_1	1131269.AQVV01000011_gene2508	5.77e-58	197.0	COG0836@1|root,COG0836@2|Bacteria	2|Bacteria	M	mannose-1-phosphate guanylyltransferase activity	manC	-	2.7.7.13,5.3.1.8,5.4.2.8	ko:K00971,ko:K01840,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01818,R01819	RC00002,RC00376,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00940	MannoseP_isomer,NTP_transferase
k59_424821_1	1265505.ATUG01000002_gene1765	9.91e-87	280.0	COG0067@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0070@2|Bacteria,1NZ4D@1224|Proteobacteria,43B3T@68525|delta/epsilon subdivisions,2X6HR@28221|Deltaproteobacteria,2MN6R@213118|Desulfobacterales	28221|Deltaproteobacteria	E	GXGXG motif	-	-	-	-	-	-	-	-	-	-	-	-	GATase_6,GXGXG
k59_1311863_1	631362.Thi970DRAFT_03746	2.01e-62	207.0	COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria	1224|Proteobacteria	L	transposase IS116 IS110 IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_835984_1	1041147.AUFB01000032_gene5880	3.01e-133	391.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,4BAAY@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_256734_1	1043493.BBLU01000002_gene1762	2.02e-38	139.0	COG2207@1|root,COG2207@2|Bacteria,2IARM@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_256734_2	1032480.MLP_09410	1.33e-22	97.4	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria,4DN9F@85009|Propionibacteriales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
k59_1311867_1	1123519.PSJM300_02145	1.4e-60	197.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RPMN@1236|Gammaproteobacteria,1Z16E@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	M	COG0859 ADP-heptose LPS heptosyltransferase	rfaC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K02841	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	iB21_1397.B21_03429,iECBD_1354.ECBD_0105,iECB_1328.ECB_03478,iECD_1391.ECD_03478,iECNA114_1301.ECNA114_3774,iECSF_1327.ECSF_3456,iSF_1195.SF3661,iS_1188.S4107	Glyco_transf_9
k59_1774339_1	1444711.CCJF01000005_gene1297	3.78e-90	270.0	COG1182@1|root,COG1182@2|Bacteria	2|Bacteria	I	oxidoreductase activity, acting on other nitrogenous compounds as donors	azoR	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008081,GO:0008150,GO:0008152,GO:0008770,GO:0009987,GO:0016787,GO:0016788,GO:0019752,GO:0032787,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0071704,GO:0140096	-	ko:K01118	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_2
k59_1250811_1	1267005.KB911257_gene1061	5.81e-146	420.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TTMF@28211|Alphaproteobacteria,3N64T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739,ko:K10764	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_131997_1	522306.CAP2UW1_3876	2.19e-53	180.0	COG3677@1|root,COG3677@2|Bacteria,1NUTK@1224|Proteobacteria,2WFCS@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Transposase zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_660309_2	710696.Intca_2740	5.84e-59	184.0	COG0256@1|root,COG0256@2|Bacteria,2IKTX@201174|Actinobacteria,4FGRA@85021|Intrasporangiaceae	201174|Actinobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0008150,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
k59_1540006_1	350058.Mvan_3810	2.29e-50	181.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,232MQ@1762|Mycobacteriaceae	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_1364064_1	1129374.AJE_14100	1.44e-44	160.0	COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria,4641T@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_1485833_1	1100720.ALKN01000045_gene316	5.23e-14	68.9	COG3093@1|root,COG3093@2|Bacteria,1N2BD@1224|Proteobacteria,2VVV1@28216|Betaproteobacteria,4AG2K@80864|Comamonadaceae	28216|Betaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
k59_1485833_2	1276920.ADIAG_00397	9.23e-48	154.0	COG3549@1|root,COG3549@2|Bacteria	2|Bacteria	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
k59_1009876_1	1232437.KL662073_gene1725	8.67e-87	275.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria,2MIMQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3394)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_1540011_1	1279017.AQYJ01000026_gene58	1.06e-67	231.0	COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,1SEWA@1236|Gammaproteobacteria,469S7@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
k59_1250838_1	335543.Sfum_1662	1.06e-13	70.5	2DDGY@1|root,2ZI1U@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1188746_1	525264.HMPREF0305_10477	2.23e-21	95.5	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,22RH4@1653|Corynebacteriaceae	201174|Actinobacteria	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1364074_1	595460.RRSWK_04882	2.97e-57	189.0	COG0631@1|root,COG0631@2|Bacteria	2|Bacteria	T	protein serine/threonine phosphatase activity	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
k59_718889_2	519989.ECTPHS_04990	5.5e-46	165.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1WWE3@135613|Chromatiales	135613|Chromatiales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1076424_1	34506.g723	1.44e-100	318.0	COG0458@1|root,KOG0370@2759|Eukaryota,38CAC@33154|Opisthokonta,3B9FF@33208|Metazoa,3CS9A@33213|Bilateria,40G12@6231|Nematoda,1KYNR@119089|Chromadorea,40UXW@6236|Rhabditida	33208|Metazoa	F	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	-	-	-	-	-	-	-	-	-	-	-	-	CPSase_L_D2,CPSase_L_D3,CPSase_sm_chain,DapB_C,DapB_N,GATase,MGS
k59_1009882_1	1279019.ARQK01000056_gene298	3.53e-24	105.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales	135613|Chromatiales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_1009882_2	454957.IA64_00505	1.02e-31	119.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1X3RT@135614|Xanthomonadales	135614|Xanthomonadales	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
k59_1250843_1	1500301.JQMF01000021_gene5085	3.38e-143	418.0	COG3119@1|root,COG3119@2|Bacteria,1MV4J@1224|Proteobacteria,2TT2I@28211|Alphaproteobacteria,4BCGZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	C-terminal region of aryl-sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_959744_1	1283300.ATXB01000001_gene1279	4.51e-14	69.3	2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SHAU@1236|Gammaproteobacteria,1XFBV@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_600682_1	765913.ThidrDRAFT_2215	3.43e-185	523.0	COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,1RMIJ@1236|Gammaproteobacteria,1WVWJ@135613|Chromatiales	135613|Chromatiales	E	ABC transporter, urea	-	-	-	ko:K11959	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	Peripla_BP_5
k59_1127508_1	411473.RUMCAL_01938	8.33e-21	105.0	COG5280@1|root,COG5412@1|root,COG5280@2|Bacteria,COG5412@2|Bacteria,1TPR1@1239|Firmicutes,25EEJ@186801|Clostridia,3WGX8@541000|Ruminococcaceae	186801|Clostridia	S	tail tape measure protein, TP901	-	-	-	-	-	-	-	-	-	-	-	-	PhageMin_Tail
k59_1540940_2	1304865.JAGF01000001_gene1408	1.77e-10	62.8	COG1276@1|root,COG3336@1|root,COG1276@2|Bacteria,COG3336@2|Bacteria,2GKIR@201174|Actinobacteria,4F132@85016|Cellulomonadaceae	201174|Actinobacteria	P	PFAM Cytochrome c oxidase caa3-type, assembly factor CtaG-related	-	-	-	ko:K02351,ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	Caa3_CtaG,CopD
k59_257856_2	986075.CathTA2_2166	1.21e-05	47.4	COG0425@1|root,COG0607@1|root,COG0425@2|Bacteria,COG0607@2|Bacteria,1V1GU@1239|Firmicutes,4HFR8@91061|Bacilli	91061|Bacilli	OP	Belongs to the sulfur carrier protein TusA family	yrkF	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,TusA
k59_1599288_1	768671.ThimaDRAFT_4368	3.82e-126	377.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1WW8W@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1659447_1	156889.Mmc1_2107	1.8e-86	269.0	COG0348@1|root,COG1152@1|root,COG0348@2|Bacteria,COG1152@2|Bacteria,1MY5M@1224|Proteobacteria,2TR0X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CK	COG3901 Regulator of nitric oxide reductase transcription	nosR	-	-	ko:K19339,ko:K19343	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind,Fer4_5
k59_961021_1	1158182.KB905021_gene831	6.25e-64	209.0	COG0644@1|root,COG0644@2|Bacteria,1MZVI@1224|Proteobacteria,1RMNS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	oxidoreductase	pltM	-	1.14.19.49	ko:K14257	ko00253,ko00404,ko01057,ko01130,map00253,map00404,map01057,map01130	M00790,M00823	R05456,R11106,R11478	RC00949	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_halogenase
k59_961026_1	1280686.AUKE01000002_gene1303	1.38e-36	141.0	COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,247R7@186801|Clostridia,4BXPN@830|Butyrivibrio	186801|Clostridia	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	-	-	3.1.11.5	ko:K01144,ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,UvrD_C_2,Viral_helicase1
k59_961026_2	331678.Cphamn1_1670	1.35e-19	86.3	COG1397@1|root,COG1397@2|Bacteria	2|Bacteria	O	ADP-ribosylglycohydrolase	draG	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH,Inositol_P
k59_80264_1	1454010.JEOE01000025_gene2958	2.09e-81	247.0	COG0125@1|root,COG0125@2|Bacteria,2GNTI@201174|Actinobacteria,4F26H@85016|Cellulomonadaceae	201174|Actinobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_1,MFS_3,Thymidylate_kin
k59_902069_1	762983.HMPREF9444_00684	9.28e-20	89.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1Y3Q8@135624|Aeromonadales	135624|Aeromonadales	JKL	DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation	deaD	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
k59_1659458_1	1121403.AUCV01000031_gene2811	3.4e-112	332.0	COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,42UZS@68525|delta/epsilon subdivisions	1224|Proteobacteria	P	NMT1-like family	-	-	-	ko:K02051,ko:K15551	ko00920,ko02010,map00920,map02010	M00188,M00435	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.1,3.A.1.17.4	-	-	NMT1,NMT1_2
k59_1486905_1	1033802.SSPSH_000272	4.48e-24	100.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_1486905_2	1218084.BBJK01000021_gene2258	1.1e-35	130.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2VNJZ@28216|Betaproteobacteria,1K33G@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.24,4.1.3.25,4.1.3.34	ko:K01644,ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01120,map01200,map02020	M00346,M00373,M00376	R00237,R00362,R00473,R00934	RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
k59_661232_1	1304874.JAFY01000002_gene133	5.71e-62	201.0	COG0444@1|root,COG0444@2|Bacteria,3TAUN@508458|Synergistetes	508458|Synergistetes	EP	ABC transporter	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran
k59_132894_1	1121952.ATXT01000014_gene1376	1.07e-128	397.0	COG2352@1|root,COG2352@2|Bacteria,2GKDB@201174|Actinobacteria,4FMP5@85023|Microbacteriaceae	201174|Actinobacteria	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_775678_1	648757.Rvan_2599	6.44e-90	267.0	COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,2TV8S@28211|Alphaproteobacteria,3N6MZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length	fabA	-	4.2.1.59,5.3.3.14	ko:K01716	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639	RC00831,RC01078,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
k59_80275_1	316067.Geob_0693	1.18e-100	298.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,42M44@68525|delta/epsilon subdivisions,2WJFW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_24180_1	765914.ThisiDRAFT_2157	1.39e-120	362.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1WW0Z@135613|Chromatiales	135613|Chromatiales	CI	TIGRFAM Oxaloacetate decarboxylase, alpha subunit	-	-	6.4.1.1	ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_308381_1	670292.JH26_02420	1.03e-35	139.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,TPR_2,TPR_8
k59_257889_1	40571.JOEA01000021_gene6826	4.58e-111	345.0	COG2304@1|root,COG2304@2|Bacteria,2GJRP@201174|Actinobacteria	201174|Actinobacteria	S	tyrosinase	-	-	1.14.18.1	ko:K00505	ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916	M00042	R00731,R02078,R02363,R02383,R04693,R04884	RC00046,RC00150,RC00180	ko00000,ko00001,ko00002,ko01000	-	-	-	Tyrosinase
k59_425734_1	396588.Tgr7_3006	5.02e-07	47.8	2EGIJ@1|root,33AAQ@2|Bacteria,1NH9B@1224|Proteobacteria,1SX44@1236|Gammaproteobacteria,1X1XD@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF2909)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2909
k59_425734_2	396588.Tgr7_3007	7.32e-155	441.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1WX89@135613|Chromatiales	135613|Chromatiales	C	PFAM cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_425734_3	2340.JV46_24780	9.74e-46	156.0	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,1S5XA@1236|Gammaproteobacteria,1J62G@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	COG3175 Cytochrome oxidase assembly factor	ctaG	-	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
k59_1251911_1	59538.XP_005972916.1	2.09e-74	243.0	COG3808@1|root,2QPJC@2759|Eukaryota	2759|Eukaryota	C	hydrogen-translocating pyrophosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	H_PPase
k59_1486913_1	1172185.KB911529_gene2621	9.3e-26	107.0	COG0025@1|root,COG0025@2|Bacteria,2I37Q@201174|Actinobacteria,4G023@85025|Nocardiaceae	201174|Actinobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_902085_1	1415778.JQMM01000001_gene1778	0.000386	43.9	COG5488@1|root,COG5488@2|Bacteria,1N9B7@1224|Proteobacteria,1SF1J@1236|Gammaproteobacteria,1J7D4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	COG5488 Integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2244
k59_961067_1	522306.CAP2UW1_1799	5.43e-64	198.0	COG5485@1|root,COG5485@2|Bacteria,1N1VS@1224|Proteobacteria	1224|Proteobacteria	S	Ester cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
k59_836928_1	1487923.DP73_16130	1.59e-80	251.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,2609R@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_373848_1	572477.Alvin_0126	7.86e-62	201.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1WX5B@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_1189667_2	670307.HYPDE_23593	4.92e-83	258.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2TS83@28211|Alphaproteobacteria,3N6KW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_836929_1	1033802.SSPSH_002045	6.95e-91	281.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Mg2 and Co2 transporter CorB	yfjD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1128366_1	670307.HYPDE_34558	4.78e-116	342.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2TRSH@28211|Alphaproteobacteria,3N6AB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_484537_1	1121405.dsmv_2195	3.43e-107	326.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria,2MIAR@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_1599337_1	1301098.PKB_4111	8.7e-06	48.5	COG0847@1|root,COG0847@2|Bacteria,1P0GY@1224|Proteobacteria,1S6UR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_1599337_2	751994.AGIG01000008_gene1150	9.74e-11	64.3	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1J4Z1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	containing cAMP-binding and CBS domains	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_661261_1	948106.AWZT01000015_gene720	1.06e-66	212.0	COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,2VHD7@28216|Betaproteobacteria,1K3VC@119060|Burkholderiaceae	28216|Betaproteobacteria	O	PFAM 20S proteasome, A and B subunits	-	-	-	ko:K07395	-	-	-	-	ko00000	-	-	-	Proteasome
k59_308404_1	448385.sce5561	2.73e-87	273.0	COG2801@1|root,COG2801@2|Bacteria,1R6TH@1224|Proteobacteria,42VCD@68525|delta/epsilon subdivisions,2WRUC@28221|Deltaproteobacteria,2YYTF@29|Myxococcales	28221|Deltaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,Mu-transpos_C,rve
k59_308404_2	448385.sce5560	1.16e-38	137.0	COG3267@1|root,COG3267@2|Bacteria,1REWJ@1224|Proteobacteria,42YV2@68525|delta/epsilon subdivisions,2WUIS@28221|Deltaproteobacteria,2Z0F4@29|Myxococcales	28221|Deltaproteobacteria	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
k59_257915_2	1123253.AUBD01000009_gene2224	3.59e-42	145.0	COG1846@1|root,COG1846@2|Bacteria,1N1CJ@1224|Proteobacteria,1SCUJ@1236|Gammaproteobacteria,1X6IP@135614|Xanthomonadales	135614|Xanthomonadales	K	MarR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
k59_257915_3	999541.bgla_1g02670	2.5e-54	181.0	COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,2VJCK@28216|Betaproteobacteria,1K3GI@119060|Burkholderiaceae	28216|Betaproteobacteria	C	4-Hydroxyphenylpyruvate dioxygenase	hppD	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
k59_1486947_1	395493.BegalDRAFT_1170	1.66e-59	186.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,46106@72273|Thiotrichales	72273|Thiotrichales	P	ApaG domain	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
k59_1716955_1	1396141.BATP01000059_gene2584	2.02e-116	342.0	COG2321@1|root,COG2321@2|Bacteria,46XBD@74201|Verrucomicrobia,2IVAT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Putative neutral zinc metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zn_peptidase
k59_1541002_1	1122214.AQWH01000064_gene1876	2.69e-81	249.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2PK0U@255475|Aurantimonadaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_1541002_2	1174684.EBMC1_15749	1.64e-46	150.0	COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2UBSS@28211|Alphaproteobacteria,2K66A@204457|Sphingomonadales	204457|Sphingomonadales	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_543331_1	857087.Metme_0199	2.29e-90	275.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1RQ2D@1236|Gammaproteobacteria,1XEAH@135618|Methylococcales	135618|Methylococcales	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
k59_909405_1	670487.Ocepr_2184	8.02e-52	198.0	COG2202@1|root,COG3437@1|root,COG2202@2|Bacteria,COG3437@2|Bacteria,1WJ3D@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	PFAM HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HD,HD_5,PAS,PAS_3,PAS_4,PAS_9
k59_1546196_1	748247.AZKH_1280	5.58e-106	313.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2VH3Z@28216|Betaproteobacteria,2KVPQ@206389|Rhodocyclales	206389|Rhodocyclales	C	Zinc-binding dehydrogenase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1546196_2	522306.CAP2UW1_1031	1.45e-10	61.6	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2VNAB@28216|Betaproteobacteria	28216|Betaproteobacteria	K	PFAM helix-turn-helix- domain containing protein, AraC type	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_430951_1	446469.Sked_33410	2.47e-17	80.9	COG1902@1|root,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria	201174|Actinobacteria	C	NADH flavin oxidoreductase NADH oxidase	namA	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_490519_1	1122604.JONR01000004_gene889	3.89e-57	200.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X5MD@135614|Xanthomonadales	135614|Xanthomonadales	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_88828_1	1121405.dsmv_2859	3.04e-44	152.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,42SVD@68525|delta/epsilon subdivisions,2WPFX@28221|Deltaproteobacteria,2MJWM@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
k59_88828_2	1192034.CAP_6495	1.07e-30	120.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,42NI7@68525|delta/epsilon subdivisions,2WNPX@28221|Deltaproteobacteria,2YUXM@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.21,5.4.99.22	ko:K06178,ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_780859_1	1366050.N234_36085	1.97e-104	314.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria,1K2WH@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Elements of external origin	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_23,HTH_32
k59_382392_2	697282.Mettu_0415	7.93e-32	121.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1XEBP@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_431702_1	331678.Cphamn1_1232	2.98e-184	526.0	COG0573@1|root,COG0573@2|Bacteria,1FE1M@1090|Chlorobi	1090|Chlorobi	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstC	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3708
k59_267551_1	2340.JV46_26690	2.89e-07	50.8	COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,1RRNM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	nitrate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_267551_2	580332.Slit_1619	1.42e-108	324.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,2VJGA@28216|Betaproteobacteria	28216|Betaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K21834	-	-	-	-	ko00000	-	-	-	CCG,DUF3483,Fer4_8
k59_314678_1	522306.CAP2UW1_3937	3.43e-20	91.3	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2VIN1@28216|Betaproteobacteria,1KR64@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	ET	PFAM extracellular solute-binding protein family 3	aapJ	-	-	ko:K02030,ko:K09969,ko:K10001	ko02010,ko02020,map02010,map02020	M00230,M00232,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.18,3.A.1.3.19,3.A.1.3.4,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
k59_490532_1	340177.Cag_1248	4.53e-81	254.0	COG2710@1|root,COG2710@2|Bacteria,1FDJS@1090|Chlorobi	1090|Chlorobi	C	This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation	-	-	1.18.6.1	ko:K02591	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
k59_382410_1	1123508.JH636450_gene7209	0.000377	48.5	COG1639@1|root,COG2204@1|root,COG1639@2|Bacteria,COG2204@2|Bacteria,2IZ5J@203682|Planctomycetes	203682|Planctomycetes	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD,Response_reg
k59_1546891_1	1304865.JAGF01000001_gene792	5.21e-53	172.0	28MMU@1|root,2ZAXG@2|Bacteria,2HAD5@201174|Actinobacteria,4F216@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1850139_1	571166.KI421509_gene1179	1.2e-86	270.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_969691_2	765912.Thimo_1803	1.05e-54	180.0	COG1363@1|root,COG1363@2|Bacteria,1MXEU@1224|Proteobacteria,1RSHP@1236|Gammaproteobacteria,1WWZP@135613|Chromatiales	135613|Chromatiales	G	peptidase M42	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
k59_549123_1	1408424.JHYI01000013_gene1059	6.96e-21	91.7	COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,4HAAI@91061|Bacilli,1ZBC5@1386|Bacillus	91061|Bacilli	S	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_1085493_1	1121434.AULY01000006_gene675	1.55e-14	78.6	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2M7WP@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_267577_2	236097.ADG881_1754	1.33e-20	87.8	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,1S22U@1236|Gammaproteobacteria,1XN5N@135619|Oceanospirillales	135619|Oceanospirillales	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1085498_1	935839.JAGJ01000002_gene753	8.66e-97	293.0	COG0216@1|root,COG0216@2|Bacteria,2GJWG@201174|Actinobacteria,4F462@85017|Promicromonosporaceae	201174|Actinobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	GO:0008150,GO:0040007	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_910715_1	935866.JAER01000005_gene229	1.67e-39	135.0	COG0735@1|root,COG0735@2|Bacteria,2IKS3@201174|Actinobacteria,4DQZK@85009|Propionibacteriales	201174|Actinobacteria	P	Belongs to the Fur family	furB	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010035,GO:0010038,GO:0010043,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_910715_2	326424.FRAAL0271	2.82e-19	86.7	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_1370995_1	2340.JV46_13300	1.97e-111	351.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J582@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18989	-	M00720	-	-	ko00000,ko00002,ko02000	2.A.6.2.30	-	-	ACR_tran
k59_33938_2	1123393.KB891329_gene999	1.94e-33	129.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,1KSQ7@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
k59_843034_1	1149133.ppKF707_2537	2.67e-29	117.0	COG0786@1|root,COG0786@2|Bacteria,1MVBC@1224|Proteobacteria,1RP0S@1236|Gammaproteobacteria,1YFH5@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Catalyzes the sodium-dependent transport of glutamate	gltS	GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005342,GO:0005343,GO:0005416,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006835,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015081,GO:0015171,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015501,GO:0015672,GO:0015711,GO:0015849,GO:0016020,GO:0017153,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0044464,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1903825,GO:1905039	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	iPC815.YPO0035,iZ_1308.Z5081	Glt_symporter
k59_607811_1	396588.Tgr7_3076	6.35e-61	194.0	COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,1RREE@1236|Gammaproteobacteria,1WWMU@135613|Chromatiales	135613|Chromatiales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_607811_2	765913.ThidrDRAFT_2826	1.13e-15	73.9	COG2920@1|root,COG2920@2|Bacteria,1MWK9@1224|Proteobacteria,1RYE1@1236|Gammaproteobacteria,1WWZ5@135613|Chromatiales	135613|Chromatiales	P	TIGRFAM sulfur relay protein, TusE DsrC DsvC family	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_1085501_1	402881.Plav_2908	1.23e-94	288.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2TQKT@28211|Alphaproteobacteria,1JN1X@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_267588_1	1380354.JIAN01000005_gene1690	5.64e-151	444.0	COG1233@1|root,COG1233@2|Bacteria,2GJAV@201174|Actinobacteria,4F0PG@85016|Cellulomonadaceae	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_1494199_1	748247.AZKH_4464	6.11e-38	142.0	COG2203@1|root,COG3576@1|root,COG2203@2|Bacteria,COG3576@2|Bacteria,1PP8V@1224|Proteobacteria,2VKHH@28216|Betaproteobacteria,2KXR2@206389|Rhodocyclales	206389|Rhodocyclales	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF_2,Putative_PNPOx
k59_1085502_1	246200.SPO3036	1.14e-132	398.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria,4ND2Q@97050|Ruegeria	28211|Alphaproteobacteria	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_197435_1	1042876.PPS_3578	2.8e-36	139.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1YWKA@136845|Pseudomonas putida group	1236|Gammaproteobacteria	O	Molecular chaperone. Has ATPase activity	htpG	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006974,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
k59_1371001_2	1131814.JAFO01000001_gene1657	3.39e-14	80.5	COG1680@1|root,COG1680@2|Bacteria,1MVZN@1224|Proteobacteria,2V5YW@28211|Alphaproteobacteria,3EZ12@335928|Xanthobacteraceae	28211|Alphaproteobacteria	V	Domain of unknown function (DUF3471)	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
k59_1085509_1	887062.HGR_08999	3.29e-69	224.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2VIS0@28216|Betaproteobacteria,4AADV@80864|Comamonadaceae	28216|Betaproteobacteria	S	peptidase dimerisation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_667096_1	1349820.M707_11660	5.29e-113	336.0	COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria,1W8QE@1268|Micrococcaceae	201174|Actinobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C,TruB_C_2,TruB_N
k59_1781484_1	765910.MARPU_04560	2.43e-116	360.0	COG0834@1|root,COG1301@1|root,COG0834@2|Bacteria,COG1301@2|Bacteria,1P22C@1224|Proteobacteria,1RSGY@1236|Gammaproteobacteria,1WZZV@135613|Chromatiales	135613|Chromatiales	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3,SDF
k59_1781484_2	765910.MARPU_04565	8.53e-57	191.0	COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria,1RYZ6@1236|Gammaproteobacteria,1X0YF@135613|Chromatiales	135613|Chromatiales	S	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028
k59_1195845_2	2340.JV46_19810	3.15e-43	147.0	COG2062@1|root,COG2062@2|Bacteria,1QBKZ@1224|Proteobacteria,1T76I@1236|Gammaproteobacteria,1J79Y@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine phosphatase superfamily (branch 1)	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
k59_88895_1	1000565.METUNv1_03846	3.52e-19	91.3	COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,2VK6P@28216|Betaproteobacteria,2KVAI@206389|Rhodocyclales	206389|Rhodocyclales	H	enzyme of heme biosynthesis	hemY	-	-	ko:K02498	-	-	-	-	ko00000	-	-	-	HemY_N
k59_138853_1	1232666.JANE01000033_gene2186	1.91e-14	78.6	COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,4HA64@91061|Bacilli,4GX2C@90964|Staphylococcaceae	91061|Bacilli	L	ATP-dependent helicase nuclease subunit A	addA	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_197446_1	1217718.ALOU01000016_gene3276	1.91e-54	190.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,1K0MD@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
k59_88897_1	1122997.AUDD01000009_gene262	5.54e-91	282.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4DNMV@85009|Propionibacteriales	201174|Actinobacteria	H	Mur ligase middle domain	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2447c	Mur_ligase_C,Mur_ligase_M
k59_1321974_1	1192868.CAIU01000008_gene1122	2.34e-82	246.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,2U71N@28211|Alphaproteobacteria,43JT3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	EVE domain	MA20_25125	-	-	-	-	-	-	-	-	-	-	-	EVE
k59_1321974_2	1267005.KB911257_gene902	1.19e-49	164.0	COG3897@1|root,COG3897@2|Bacteria,1N9VC@1224|Proteobacteria,2TV6N@28211|Alphaproteobacteria,3N714@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Ribosomal protein L11 methyltransferase (PrmA)	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010565,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018022,GO:0018023,GO:0018193,GO:0018205,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031974,GO:0031998,GO:0031999,GO:0032259,GO:0036211,GO:0043086,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043414,GO:0043467,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045833,GO:0045922,GO:0046320,GO:0046322,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050994,GO:0050995,GO:0051341,GO:0051354,GO:0062012,GO:0062014,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1904732,GO:1904733,GO:1904735,GO:1904736	-	-	-	-	-	-	-	-	-	-	PrmA
k59_1195849_1	1255043.TVNIR_1306	1.89e-25	107.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	ybbN	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_267629_1	237368.SCABRO_02415	5.44e-68	218.0	COG0598@1|root,COG0598@2|Bacteria,2IX61@203682|Planctomycetes	203682|Planctomycetes	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_1850203_1	765912.Thimo_0612	5.83e-91	284.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1WWPS@135613|Chromatiales	135613|Chromatiales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_725566_1	1328313.DS2_15714	4.04e-89	280.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RQHM@1236|Gammaproteobacteria,467Q9@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Alpha amylase, catalytic domain	malZ	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004558,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009311,GO:0009313,GO:0009987,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0051691,GO:0051692,GO:0071704,GO:0090599,GO:1901575	3.2.1.135,3.2.1.20	ko:K01187,ko:K21575	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH13,GH31	iECH74115_1262.ECH74115_0480,iEcSMS35_1347.EcSMS35_0434,iSFV_1184.SFV_0368,iYL1228.KPN_00344	Alpha-amylase,Alpha-amylase_N,Malt_amylase_C
k59_1665747_1	1134474.O59_001818	2.33e-59	195.0	COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria,1FG4J@10|Cellvibrio	1236|Gammaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	cysB	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363	-	ko:K13634	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_88906_1	497964.CfE428DRAFT_3128	3.49e-24	107.0	COG1505@1|root,COG1505@2|Bacteria,46TIX@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_267638_1	1049564.TevJSym_al00340	2.16e-42	147.0	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,1RQBE@1236|Gammaproteobacteria,1JA5R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	AIR synthase related protein, N-terminal domain	hypE	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0018193,GO:0018198,GO:0018249,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046892,GO:0051604,GO:0071704,GO:1901564	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
k59_267638_2	1123393.KB891326_gene126	6.04e-126	387.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,2VHS4@28216|Betaproteobacteria,1KSM8@119069|Hydrogenophilales	119069|Hydrogenophilales	O	HypF finger	-	-	-	-	-	-	-	-	-	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_1605108_1	1298867.AUES01000051_gene4506	7.26e-20	90.9	COG1994@1|root,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,2U0H8@28211|Alphaproteobacteria,3K33G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Peptidase, M50 family	-	-	-	ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	Biotin_lipoyl_2,HlyD_3,PqqD
k59_1605108_2	330214.NIDE2722	2.13e-100	317.0	COG0653@1|root,COG0653@2|Bacteria,3J0E5@40117|Nitrospirae	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SecA_DEAD,SecA_PP_bind,SecA_SW
k59_88919_1	1123508.JH636439_gene1271	1.66e-149	430.0	COG1064@1|root,COG1064@2|Bacteria,2IY4H@203682|Planctomycetes	203682|Planctomycetes	C	alcohol dehydrogenase	-	-	-	ko:K12957	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_431775_2	472759.Nhal_2148	1.83e-74	234.0	COG0430@1|root,COG0430@2|Bacteria,1MX7Q@1224|Proteobacteria,1RSFF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	A	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009975,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
k59_1195864_1	589865.DaAHT2_1452	3.35e-43	149.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,42NV2@68525|delta/epsilon subdivisions,2WNJ1@28221|Deltaproteobacteria,2MJKX@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_314743_1	1131553.JIBI01000019_gene479	6.33e-22	95.5	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VJ86@28216|Betaproteobacteria,372E5@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
k59_667122_1	716544.wcw_0511	7.89e-57	193.0	COG0388@1|root,COG1247@1|root,COG0388@2|Bacteria,COG1247@2|Bacteria,2JGRN@204428|Chlamydiae	204428|Chlamydiae	K	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
k59_34015_1	870187.Thini_2468	7.4e-182	528.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,45ZT1@72273|Thiotrichales	72273|Thiotrichales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_138872_1	289376.THEYE_A0758	1.32e-63	216.0	COG0466@1|root,COG0466@2|Bacteria,3J0DQ@40117|Nitrospirae	40117|Nitrospirae	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,Lon_C,Response_reg
k59_1015827_2	1122603.ATVI01000006_gene460	3.22e-25	97.1	COG0346@1|root,COG0346@2|Bacteria,1RE6F@1224|Proteobacteria,1SP6R@1236|Gammaproteobacteria,1X75F@135614|Xanthomonadales	135614|Xanthomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_1430917_1	335543.Sfum_1230	7.49e-36	126.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,42VQ6@68525|delta/epsilon subdivisions,2WRTU@28221|Deltaproteobacteria,2MQNU@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
k59_1430917_2	309807.SRU_1005	8.78e-06	47.8	COG0618@1|root,COG0618@2|Bacteria,4NEXE@976|Bacteroidetes,1FIPH@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	DHH family	nrnA	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_1259839_1	617140.AJZE01000078_gene1847	0.000499	42.7	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGA@1236|Gammaproteobacteria,1XXNF@135623|Vibrionales	135623|Vibrionales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1259839_2	504487.JCM19302_3553	7.88e-30	115.0	COG1228@1|root,COG1228@2|Bacteria,4NFI3@976|Bacteroidetes,1HY2V@117743|Flavobacteriia	976|Bacteroidetes	Q	Imidazolonepropionase and related	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1322018_1	870187.Thini_2275	3.05e-82	257.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,45ZST@72273|Thiotrichales	72273|Thiotrichales	H	MoeA N-terminal region (domain I and II)	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MobB,MoeA_C,MoeA_N,NTP_transf_3
k59_910811_1	1255043.TVNIR_2381	1.42e-41	155.0	COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1WWSK@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB
k59_910811_2	545276.KB898724_gene2005	7.76e-96	292.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,1WX3R@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
k59_725594_2	586413.CCDL010000001_gene1218	2.06e-21	95.9	COG1680@1|root,COG1680@2|Bacteria,1V3KP@1239|Firmicutes,4IDK5@91061|Bacilli,23KW4@182709|Oceanobacillus	91061|Bacilli	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1723163_1	1121396.KB893107_gene1850	8.3e-60	196.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,2MHWD@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	type II secretion system	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_1494288_1	909663.KI867150_gene433	4e-33	129.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MQB7@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Belongs to the peptidase S1C family	degP-2	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_1259865_1	935848.JAEN01000004_gene1180	1.59e-42	157.0	COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,2TQVR@28211|Alphaproteobacteria,2PUH0@265|Paracoccus	28211|Alphaproteobacteria	L	Nucleotidyltransferase DNA polymerase involved in DNA repair	imuB	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS,IMS_C
k59_1500267_1	1307761.L21SP2_2105	7.14e-54	190.0	COG3605@1|root,COG3605@2|Bacteria,2JBCF@203691|Spirochaetes	203691|Spirochaetes	T	GAF domain	-	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_920408_1	156889.Mmc1_3384	6.72e-60	202.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,2TTGG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cusB	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	CusF_Ec,HlyD_D23,HlyD_D4
k59_1610200_1	1049564.TevJSym_ap00050	2.27e-73	243.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J57S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	cation transport ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
k59_1728597_1	1386089.N865_19270	2.6e-76	250.0	COG1299@1|root,COG1445@1|root,COG1762@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,COG1762@2|Bacteria,2GJU4@201174|Actinobacteria,4FG55@85021|Intrasporangiaceae	201174|Actinobacteria	G	Phosphotransferase system, EIIC	fruA	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2,PTS_EIIC,PTS_IIB
k59_1331721_1	631362.Thi970DRAFT_02933	1.98e-119	360.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1WWTY@135613|Chromatiales	135613|Chromatiales	FP	Belongs to the GppA Ppx family	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_274832_1	1121405.dsmv_1751	2.03e-52	176.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42N64@68525|delta/epsilon subdivisions,2WJ73@28221|Deltaproteobacteria,2MIX5@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1436243_1	1435051.BMOU_1960	8.04e-15	73.2	COG0274@1|root,COG0274@2|Bacteria,2GJIR@201174|Actinobacteria,4D0DC@85004|Bifidobacteriales	201174|Actinobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
k59_1436243_2	351607.Acel_0793	6.29e-16	77.4	COG1159@1|root,COG1159@2|Bacteria,2GJJE@201174|Actinobacteria,4ERS4@85013|Frankiales	201174|Actinobacteria	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
k59_274835_2	553385.JEMF01000020_gene3032	4.86e-53	178.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1XIZA@135619|Oceanospirillales	135619|Oceanospirillales	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_979528_1	367299.JOEE01000004_gene1354	1.22e-108	322.0	COG0275@1|root,COG0275@2|Bacteria,2GJGK@201174|Actinobacteria,4FETT@85021|Intrasporangiaceae	201174|Actinobacteria	M	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_1376114_1	28072.Nos7524_1286	4.55e-23	105.0	COG2931@1|root,COG3210@1|root,COG3291@1|root,COG3595@1|root,COG4070@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG3595@2|Bacteria,COG4070@2|Bacteria,1GHDQ@1117|Cyanobacteria,1HUA0@1161|Nostocales	1117|Cyanobacteria	Q	Domain of unknown function (DUF4114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114
k59_144217_1	1123392.AQWL01000006_gene638	1.08e-31	126.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VHTK@28216|Betaproteobacteria,1KRZ9@119069|Hydrogenophilales	119069|Hydrogenophilales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_202764_1	768671.ThimaDRAFT_1123	1.26e-08	55.1	COG1443@1|root,COG1443@2|Bacteria,1R9YJ@1224|Proteobacteria,1S6ZT@1236|Gammaproteobacteria,1WW7S@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)	idi	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
k59_1500280_2	765914.ThisiDRAFT_0781	1.42e-18	81.3	COG4968@1|root,COG4968@2|Bacteria,1N6QE@1224|Proteobacteria,1SCBS@1236|Gammaproteobacteria,1WZ6E@135613|Chromatiales	135613|Chromatiales	NU	Type IV minor pilin ComP, DNA uptake sequence receptor	-	-	-	ko:K02655	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	ComP_DUS,N_methyl
k59_785432_1	502025.Hoch_5996	4.11e-63	206.0	COG1075@1|root,COG1075@2|Bacteria,1QTCH@1224|Proteobacteria,437VW@68525|delta/epsilon subdivisions,2WYPR@28221|Deltaproteobacteria,2YUCF@29|Myxococcales	28221|Deltaproteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_672463_1	1238182.C882_2178	9.82e-85	267.0	COG2391@1|root,COG2391@2|Bacteria,1PF9B@1224|Proteobacteria,2TU5N@28211|Alphaproteobacteria,2JQTX@204441|Rhodospirillales	204441|Rhodospirillales	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_1500282_1	686578.AFFX01000006_gene3397	7.47e-31	124.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	GO:0000166,GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008854,GO:0009314,GO:0009338,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017076,GO:0017111,GO:0030554,GO:0032392,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044355,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0099046,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_979544_1	290399.Arth_3167	5.5e-35	137.0	COG1404@1|root,COG3291@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PKD,SLH
k59_1265859_1	1279017.AQYJ01000024_gene1082	7.5e-05	44.7	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,465IN@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	iECO103_1326.ECO103_0087,iECO111_1330.ECO111_0088,iECW_1372.ECW_m0084,iEKO11_1354.EKO11_3829,iWFL_1372.ECW_m0084,ic_1306.c0103	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1265859_2	272624.lpg2618	1.07e-28	116.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1JC9H@118969|Legionellales	118969|Legionellales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1500283_1	765912.Thimo_1174	2.8e-106	327.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1WW41@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_98625_1	396588.Tgr7_0968	5.37e-57	194.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1WW15@135613|Chromatiales	135613|Chromatiales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_144226_2	314256.OG2516_09548	4.25e-37	133.0	COG0077@1|root,COG0077@2|Bacteria,1MU60@1224|Proteobacteria,2TSUT@28211|Alphaproteobacteria,2PCI8@252301|Oceanicola	28211|Alphaproteobacteria	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	PDT
k59_554562_1	443143.GM18_4037	7.33e-48	177.0	COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,42T0V@68525|delta/epsilon subdivisions,2WPRT@28221|Deltaproteobacteria,43TPS@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
k59_1020303_1	266264.Rmet_0054	2.62e-110	342.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,1K061@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_1331774_1	1121935.AQXX01000143_gene4259	1.78e-18	85.9	2AYXV@1|root,31R3M@2|Bacteria,1RHPG@1224|Proteobacteria,1SYAS@1236|Gammaproteobacteria,1XRH1@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_98645_1	520999.PROVALCAL_00413	7.24e-46	160.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,3Z7YD@586|Providencia	1236|Gammaproteobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_1786107_2	525256.HMPREF0091_10897	1.55e-28	103.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria,4CWAW@84998|Coriobacteriia	84998|Coriobacteriia	K	'Cold-shock' DNA-binding domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_41704_1	1121875.KB907546_gene2199	2.02e-70	229.0	COG3653@1|root,COG3653@2|Bacteria,4NHDD@976|Bacteroidetes,1I2RR@117743|Flavobacteriia	976|Bacteroidetes	Q	PFAM D-aminoacylase, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_1786109_1	1043493.BBLU01000017_gene1380	2.98e-68	221.0	COG3004@1|root,COG3004@2|Bacteria,2GKIK@201174|Actinobacteria	201174|Actinobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_554576_1	631362.Thi970DRAFT_04937	1.65e-05	47.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1WVVQ@135613|Chromatiales	135613|Chromatiales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_554576_2	1249627.D779_1800	6.85e-84	255.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria,1WXA6@135613|Chromatiales	135613|Chromatiales	H	riboflavin synthase, alpha subunit	-	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
k59_554576_3	1335757.SPICUR_02445	1.43e-47	163.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1WW6K@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_979589_1	460265.Mnod_4476	3.62e-77	239.0	COG3367@1|root,COG3367@2|Bacteria,1MVEX@1224|Proteobacteria,2TS0Y@28211|Alphaproteobacteria,1JSSD@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
k59_1376145_1	765910.MARPU_10720	5.18e-19	84.3	COG4659@1|root,COG4659@2|Bacteria,1R6FE@1224|Proteobacteria,1RYZ7@1236|Gammaproteobacteria,1WXWE@135613|Chromatiales	135613|Chromatiales	U	Part of a membrane complex involved in electron transport	-	-	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
k59_1020314_1	991905.SL003B_2021	1.05e-93	285.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQXI@28211|Alphaproteobacteria,4BPQT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Aminotransferase class I and II	hemA	-	2.3.1.37	ko:K00643	ko00260,ko00860,ko01100,ko01110,map00260,map00860,map01100,map01110	-	R00830	RC00004,RC02815	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1671191_1	1121377.KB906399_gene1557	7.87e-42	156.0	COG0058@1|root,COG0058@2|Bacteria,1WIR5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Alpha-glucan phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_1610237_1	105425.BBPL01000038_gene2900	6.73e-14	71.6	2EP16@1|root,33GN1@2|Bacteria,2IHWQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1610237_2	446462.Amir_4981	1.07e-36	130.0	2BX7X@1|root,32RMD@2|Bacteria,2IKN7@201174|Actinobacteria,4E4BS@85010|Pseudonocardiales	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1092640_2	316056.RPC_1328	1.53e-59	186.0	COG4451@1|root,COG4451@2|Bacteria,1R9ZE@1224|Proteobacteria,2U7JJ@28211|Alphaproteobacteria,3JY43@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	ribulose bisphosphate carboxylase, small chain	cbbS	-	4.1.1.39	ko:K01602	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_small
k59_673335_1	247633.GP2143_11814	7.38e-63	210.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,1RP2E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	flavoprotein involved in K transport	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,FMO-like,Pyr_redox_3
k59_731884_1	765914.ThisiDRAFT_2644	4.11e-55	182.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,1RPYX@1236|Gammaproteobacteria,1WX9X@135613|Chromatiales	135613|Chromatiales	O	PFAM Peptidase M22, glycoprotease	-	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
k59_731884_2	1163617.SCD_n01354	8.05e-91	281.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VMTA@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
k59_1333165_1	330214.NIDE2144	8.3e-24	93.2	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	GO:0001666,GO:0006355,GO:0006950,GO:0008150,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010565,GO:0010605,GO:0010629,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036293,GO:0040008,GO:0045892,GO:0045926,GO:0045927,GO:0045934,GO:0048518,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0062012,GO:0065007,GO:0070482,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_37
k59_99981_1	1380393.JHVP01000003_gene889	2.4e-47	164.0	COG0500@1|root,COG2226@2|Bacteria,2II6G@201174|Actinobacteria,4EUPA@85013|Frankiales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_614051_2	765913.ThidrDRAFT_3355	1.09e-30	112.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,1S3WS@1236|Gammaproteobacteria,1WYD2@135613|Chromatiales	135613|Chromatiales	J	binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
k59_1552883_1	765910.MARPU_00360	5.66e-89	271.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1WVX9@135613|Chromatiales	135613|Chromatiales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_438041_2	519989.ECTPHS_09692	3.03e-27	110.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1WVWH@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_1501258_1	240016.ABIZ01000001_gene5341	2.66e-98	299.0	COG3287@1|root,COG3287@2|Bacteria	2|Bacteria	M	FIST C domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C,GGDEF
k59_1201992_1	913325.N799_08250	3e-72	229.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1X4E4@135614|Xanthomonadales	135614|Xanthomonadales	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_921895_1	497964.CfE428DRAFT_0657	3.17e-118	348.0	COG0686@1|root,COG0686@2|Bacteria,46S7U@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Alanine dehydrogenase/PNT, C-terminal domain	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_1729423_1	1485545.JQLW01000008_gene1975	1.44e-55	189.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria	1224|Proteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_1786794_1	1284679.HMPREF1626_11230	2.07e-35	139.0	COG1112@1|root,COG1112@2|Bacteria,2GKJW@201174|Actinobacteria,4D48N@85005|Actinomycetales	201174|Actinobacteria	L	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DUF4011
k59_1020970_1	439497.RR11_2954	6.26e-114	348.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,2TUJB@28211|Alphaproteobacteria,4N9VY@97050|Ruegeria	28211|Alphaproteobacteria	C	Domain of unknown function (DUF4445)	nqrF	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
k59_1729427_1	631362.Thi970DRAFT_02774	1.75e-84	276.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1437081_1	1184607.AUCHE_09_00450	2.94e-97	299.0	COG1085@1|root,COG1085@2|Bacteria,2IA73@201174|Actinobacteria,4F63M@85018|Dermatophilaceae	201174|Actinobacteria	C	Domain of unknown function (DUF4921)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4921
k59_496789_1	335543.Sfum_1545	7.6e-74	223.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,42RE7@68525|delta/epsilon subdivisions,2WNAH@28221|Deltaproteobacteria,2MRIX@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_1671988_1	1049564.TevJSym_ap00490	7.48e-55	187.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1J5NF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_981016_1	1035308.AQYY01000001_gene2467	4.85e-75	246.0	COG0515@1|root,COG0515@2|Bacteria,1VRBY@1239|Firmicutes,24ZDV@186801|Clostridia	186801|Clostridia	KLT	Protein kinase G tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,PknG_TPR,PknG_rubred
k59_320984_1	247633.GP2143_08039	1.3e-93	285.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1J4CP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K01766,ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,SufE
k59_849193_1	208444.JNYY01000001_gene5116	5.6e-14	81.3	COG0151@1|root,COG0151@2|Bacteria,2GXFQ@201174|Actinobacteria,4EAEV@85010|Pseudonocardiales	201174|Actinobacteria	F	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
k59_203646_1	2340.JV46_21610	1.93e-11	63.2	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1J4WK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009898,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_203646_2	999141.GME_14510	1.99e-38	140.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1XHSK@135619|Oceanospirillales	135619|Oceanospirillales	J	SAM-dependent	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
k59_981036_1	652103.Rpdx1_4578	2.29e-13	68.6	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,2TTXU@28211|Alphaproteobacteria,3JQYQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
k59_981036_2	582899.Hden_2505	8.02e-46	160.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2TRHW@28211|Alphaproteobacteria,3N6U6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	MA20_05390	-	2.1.1.79	ko:K00574,ko:K18164	ko04714,map04714	-	-	-	ko00000,ko00001,ko01000,ko03029	-	-	-	Methyltransf_28
k59_1092694_1	2340.JV46_25740	3.08e-98	301.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1J4IM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_3999	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
k59_1729450_1	1382358.JHVN01000010_gene1539	6.99e-11	65.5	COG0697@1|root,COG0697@2|Bacteria,1V0DI@1239|Firmicutes,4HD1I@91061|Bacilli,21VHE@150247|Anoxybacillus	91061|Bacilli	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1729450_2	596151.DesfrDRAFT_0563	6.55e-07	49.7	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42N9E@68525|delta/epsilon subdivisions,2WJAX@28221|Deltaproteobacteria,2M7YX@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_43042_1	89187.ISM_10411	3.63e-129	379.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2TR8F@28211|Alphaproteobacteria,46NXA@74030|Roseovarius	28211|Alphaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	soxH	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1266939_1	697282.Mettu_2187	1.54e-129	396.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XEFJ@135618|Methylococcales	135618|Methylococcales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_43051_1	1348663.KCH_58320	1.02e-07	54.3	COG1071@1|root,COG1071@2|Bacteria,2I3T8@201174|Actinobacteria,2M0Y7@2063|Kitasatospora	201174|Actinobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_1020998_1	1492738.FEM21_13360	6.24e-49	172.0	COG2755@1|root,COG2755@2|Bacteria,4NK31@976|Bacteroidetes,1IJC8@117743|Flavobacteriia,2NYRM@237|Flavobacterium	976|Bacteroidetes	E	Carbohydrate esterase, sialic acid-specific acetylesterase	-	-	3.1.1.53	ko:K05970	-	-	-	-	ko00000,ko01000	-	-	-	Lipase_GDSL_2,SASA
k59_1266943_1	1265505.ATUG01000001_gene3198	2.18e-28	113.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42Q13@68525|delta/epsilon subdivisions,2WJHD@28221|Deltaproteobacteria,2MJ10@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM dihydropteroate synthase DHPS	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
k59_1333252_1	290397.Adeh_4122	2.33e-54	195.0	COG0784@1|root,COG0840@1|root,COG1511@1|root,COG4251@1|root,COG0784@2|Bacteria,COG0840@2|Bacteria,COG1511@2|Bacteria,COG4251@2|Bacteria,1NC9X@1224|Proteobacteria,43BZ2@68525|delta/epsilon subdivisions,2X79T@28221|Deltaproteobacteria,2YU1H@29|Myxococcales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,Response_reg
k59_1786822_2	870187.Thini_3573	4.23e-57	181.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria,460KF@72273|Thiotrichales	72273|Thiotrichales	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
k59_100065_1	1121382.JQKG01000008_gene1012	5.61e-43	154.0	COG1156@1|root,COG1156@2|Bacteria,1WIDT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_100065_2	1249627.D779_2949	3.74e-20	89.7	COG1394@1|root,COG1394@2|Bacteria,1RJ1P@1224|Proteobacteria,1S75D@1236|Gammaproteobacteria,1WYND@135613|Chromatiales	135613|Chromatiales	C	ATP synthase subunit D	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
k59_1792112_2	1026882.MAMP_00207	1.3e-43	158.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,46096@72273|Thiotrichales	72273|Thiotrichales	C	Belongs to the heme-copper respiratory oxidase family	cyoB	-	1.10.3.10,1.9.3.1	ko:K02274,ko:K02298	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081,R11335	RC00016,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX1
k59_679703_1	330214.NIDE3498	1.46e-79	264.0	COG2203@1|root,COG3604@1|root,COG2203@2|Bacteria,COG3604@2|Bacteria	2|Bacteria	KT	transcription factor binding	fhlA	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141	-	ko:K02584,ko:K12146,ko:K12266,ko:K15836,ko:K21009	ko02020,ko02025,ko05132,map02020,map02025,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,GAF_3,HTH_8,Sigma54_activat
k59_109808_1	1415778.JQMM01000001_gene522	5.63e-55	176.0	COG2259@1|root,COG2259@2|Bacteria,1N06A@1224|Proteobacteria,1S92U@1236|Gammaproteobacteria,1J714@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
k59_1559073_1	1122185.N792_00500	4.29e-36	137.0	COG0591@1|root,COG0642@1|root,COG0745@1|root,COG0591@2|Bacteria,COG0745@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,1X43U@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
k59_1343160_1	367299.JOEE01000008_gene633	2.86e-110	321.0	COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,4FFQG@85021|Intrasporangiaceae	201174|Actinobacteria	P	Part of an ABC transporter complex. Responsible for energy coupling to the transport system	cbiO	-	-	ko:K02006,ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
k59_444186_1	1565129.JSFF01000002_gene3601	5.55e-62	207.0	COG3104@1|root,COG3104@2|Bacteria,1P6K2@1224|Proteobacteria,1RZ5I@1236|Gammaproteobacteria,2Q8GE@267890|Shewanellaceae	1236|Gammaproteobacteria	E	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1735450_1	926550.CLDAP_21950	3.17e-59	198.0	COG2303@1|root,COG2303@2|Bacteria,2G7EB@200795|Chloroflexi	200795|Chloroflexi	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_284442_1	1121013.P873_02390	4.42e-24	95.9	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,1S90Z@1236|Gammaproteobacteria,1X8MH@135614|Xanthomonadales	135614|Xanthomonadales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_284442_2	713586.KB900536_gene2663	2.27e-37	128.0	COG2863@1|root,COG2863@2|Bacteria,1MZU1@1224|Proteobacteria,1SBJR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_284442_3	637389.Acaty_c1491	2.94e-24	97.8	COG1416@1|root,COG1416@2|Bacteria,1N0U1@1224|Proteobacteria,1SGKY@1236|Gammaproteobacteria,2NCV2@225057|Acidithiobacillales	225057|Acidithiobacillales	S	DsrE/DsrF-like family	-	-	-	ko:K09004	-	-	-	-	ko00000	-	-	-	DrsE
k59_990949_1	580332.Slit_2788	2.86e-10	62.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VQF1@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_990949_2	314278.NB231_15718	4.49e-25	96.7	COG2963@1|root,COG2963@2|Bacteria,1N8Y3@1224|Proteobacteria	1224|Proteobacteria	L	PFAM transposase IS3 IS911 family protein	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1735456_1	1437425.CSEC_1957	2.33e-09	62.8	COG1940@1|root,COG1940@2|Bacteria,2JFZN@204428|Chlamydiae	204428|Chlamydiae	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_284445_1	1306174.JODP01000013_gene7459	1.58e-165	477.0	COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria	201174|Actinobacteria	E	Glutamate synthase	gltD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3858c	Fer4_20,Pyr_redox_2
k59_1026080_1	690850.Desaf_3653	1.33e-119	348.0	COG0834@1|root,COG0834@2|Bacteria,1MV3Q@1224|Proteobacteria,42PQN@68525|delta/epsilon subdivisions,2WMA2@28221|Deltaproteobacteria,2M9PI@213115|Desulfovibrionales	28221|Deltaproteobacteria	ET	PFAM Extracellular solute-binding protein, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_1559095_1	95619.PM1_0217260	2.85e-78	246.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Succinyldiaminopimelate	dapC	-	2.6.1.17	ko:K14261,ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_990980_2	1212548.B381_01450	1.39e-31	115.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria,1Z2QK@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
k59_1678174_2	1346791.M529_07650	4.16e-40	147.0	COG1680@1|root,COG1680@2|Bacteria,1MY01@1224|Proteobacteria,2U2RG@28211|Alphaproteobacteria,2K0XM@204457|Sphingomonadales	204457|Sphingomonadales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_738330_1	1538295.JY96_00790	3.9e-117	339.0	COG2057@1|root,COG2057@2|Bacteria,1RA4V@1224|Proteobacteria,2VII6@28216|Betaproteobacteria,1KKFA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	3-oxoacid CoA-transferase, B subunit	scoB	-	2.8.3.5	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_502823_1	911045.PSE_1277	1.27e-09	65.1	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2U2CU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_991009_1	491915.Aflv_2528	1.04e-07	54.3	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,4HA4N@91061|Bacilli,21VK2@150247|Anoxybacillus	91061|Bacilli	C	Pyridine nucleotide-disulphide oxidoreductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_209892_1	1173025.GEI7407_0335	2.38e-53	172.0	COG2954@1|root,COG2954@2|Bacteria,1G5NQ@1117|Cyanobacteria,1HB3Z@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM CYTH domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CYTH
k59_1383334_1	265311.Mfl369	0.00039	51.2	COG2333@1|root,COG2333@2|Bacteria,3WTAM@544448|Tenericutes	544448|Tenericutes	S	Metallo-beta-lactamase superfamily	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_1099376_1	582899.Hden_1424	1.26e-56	189.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TRCP@28211|Alphaproteobacteria,3N9G1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	glutamine synthetase	glnA1	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_1273839_1	519989.ECTPHS_01359	6.5e-50	169.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1WXMZ@135613|Chromatiales	135613|Chromatiales	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_1273839_2	1385517.N800_06880	2.38e-25	99.0	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria,1X643@135614|Xanthomonadales	135614|Xanthomonadales	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
k59_1792166_1	314225.ELI_14900	2.7e-116	340.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2K2F6@204457|Sphingomonadales	204457|Sphingomonadales	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_931819_1	493475.GARC_1054	4.75e-93	282.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,46517@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iE2348C_1286.E2348C_2469,iEC55989_1330.EC55989_2573,iECO103_1326.ECO103_2794,iECO111_1330.ECO111_3077,iECO26_1355.ECO26_3317,iECSE_1348.ECSE_2638,iECW_1372.ECW_m2518,iEKO11_1354.EKO11_1436,iSSON_1240.SSON_2387,iUMNK88_1353.UMNK88_2882,iWFL_1372.ECW_m2518	Chorismate_synt
k59_1871443_1	1123269.NX02_10705	3.36e-35	129.0	COG0847@1|root,COG0847@2|Bacteria,1RDF2@1224|Proteobacteria,2U73W@28211|Alphaproteobacteria,2K558@204457|Sphingomonadales	204457|Sphingomonadales	L	Exonuclease	-	-	-	-	-	-	-	-	-	-	-	-	RNase_T
k59_855275_2	713586.KB900536_gene1601	1.27e-229	642.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1WX4J@135613|Chromatiales	135613|Chromatiales	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_1508226_1	1095767.CAHD01000193_gene198	1.38e-56	198.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria	201174|Actinobacteria	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_1792179_2	292415.Tbd_0845	3.3e-15	73.9	COG1573@1|root,COG1573@2|Bacteria,1R9XV@1224|Proteobacteria,2VQ52@28216|Betaproteobacteria	28216|Betaproteobacteria	L	uracil-DNA glycosylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF488,UDG
k59_1208029_1	1121875.KB907550_gene636	3.06e-59	202.0	COG2015@1|root,COG2015@2|Bacteria,4NJE2@976|Bacteroidetes	976|Bacteroidetes	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_1443263_1	1112274.KI911560_gene1203	0.000655	45.4	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,2VIDH@28216|Betaproteobacteria,2KMNV@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
k59_1617397_1	319224.Sputcn32_0673	1.51e-77	234.0	COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,1S2DE@1236|Gammaproteobacteria,2QB2K@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Uncharacterized protein family, UPF0114	yqhA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	UPF0114
k59_1144919_1	1120956.JHZK01000001_gene3467	1.94e-111	327.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TQKB@28211|Alphaproteobacteria,1JMYX@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	-	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Succ_CoA_lig
k59_444250_1	1177928.TH2_13794	4.34e-104	317.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2TUAE@28211|Alphaproteobacteria,2JQ8D@204441|Rhodospirillales	204441|Rhodospirillales	F	Belongs to the 5'-nucleotidase family	-	-	-	ko:K17224	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	5_nucleotid_C
k59_284521_1	593907.Celgi_0031	2.35e-88	274.0	COG0772@1|root,COG0772@2|Bacteria,2GJTI@201174|Actinobacteria,4F0QR@85016|Cellulomonadaceae	201174|Actinobacteria	D	Belongs to the SEDS family	rodA	GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_1026130_1	246197.MXAN_4369	6.44e-28	108.0	COG0500@1|root,COG2226@2|Bacteria,1QXUQ@1224|Proteobacteria,43C7B@68525|delta/epsilon subdivisions,2X7HM@28221|Deltaproteobacteria,2Z3GI@29|Myxococcales	28221|Deltaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_1026130_2	706191.PANA_3951	1.08e-25	107.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,3VY2T@53335|Pantoea	1236|Gammaproteobacteria	T	Response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes	glnG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1144923_1	4572.TRIUR3_31040-P1	1.11e-16	87.0	COG0405@1|root,KOG2410@2759|Eukaryota,37HV8@33090|Viridiplantae,3G7AM@35493|Streptophyta,3KQ4Q@4447|Liliopsida,3I2YE@38820|Poales	35493|Streptophyta	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1144923_2	1120983.KB894575_gene568	9.83e-05	43.5	COG0627@1|root,COG0627@2|Bacteria,1MUID@1224|Proteobacteria,2TQSM@28211|Alphaproteobacteria,1JNEA@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Serine hydrolase involved in the detoxification of formaldehyde	-	-	3.1.2.12	ko:K01070	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R00527	RC00167,RC00320	ko00000,ko00001,ko01000	-	CE1	-	Esterase
k59_403454_1	572477.Alvin_1406	1.36e-65	214.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1WWIH@135613|Chromatiales	135613|Chromatiales	CP	PFAM NADH Ubiquinone plastoquinone	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
k59_403454_2	472759.Nhal_1815	7.94e-13	70.1	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RYB4@1236|Gammaproteobacteria,1WVUT@135613|Chromatiales	135613|Chromatiales	CP	PFAM NADH Ubiquinone plastoquinone	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_1871483_1	1279017.AQYJ01000025_gene640	5.24e-07	57.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1RNWV@1236|Gammaproteobacteria,4660S@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	TonB-dependent Receptor Plug Domain	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1735535_1	667014.Thein_1468	7.13e-40	136.0	COG0091@1|root,COG0091@2|Bacteria,2GHXI@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_1735535_2	742743.HMPREF9453_01313	5.9e-09	55.8	COG0092@1|root,COG0092@2|Bacteria,1TPCP@1239|Firmicutes,4H3BP@909932|Negativicutes	909932|Negativicutes	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_1508239_1	266264.Rmet_3232	6.17e-75	233.0	COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,2VIX1@28216|Betaproteobacteria,1K03Z@119060|Burkholderiaceae	28216|Betaproteobacteria	S	NIF3 (NGG1p interacting factor 3)	ybgI	-	-	-	-	-	-	-	-	-	-	-	NIF3
k59_1617408_1	439235.Dalk_2445	3.11e-131	382.0	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,42NAI@68525|delta/epsilon subdivisions,2WJYY@28221|Deltaproteobacteria,2MIP2@213118|Desulfobacterales	28221|Deltaproteobacteria	P	sulfate adenylyltransferase	sat	-	2.7.1.25,2.7.7.4	ko:K00958,ko:K13811	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
k59_791164_1	644107.SL1157_1112	1.32e-21	94.4	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,4N9V0@97050|Ruegeria	28211|Alphaproteobacteria	V	ABC transporter, transmembrane ATP-binding protein	abcT3	-	-	ko:K06147,ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1735539_1	396588.Tgr7_2295	2.92e-92	295.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1WX68@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_444265_1	1120950.KB892766_gene5124	8.86e-27	111.0	COG4222@1|root,COG4222@2|Bacteria	2|Bacteria	S	Esterase-like activity of phytase	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	CHRD,DUF839,HemolysinCabind,Phytase-like
k59_679804_2	765914.ThisiDRAFT_0827	2.52e-09	59.3	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,1RPBP@1236|Gammaproteobacteria,1WZ40@135613|Chromatiales	135613|Chromatiales	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
k59_1617422_1	314345.SPV1_09553	1.05e-46	159.0	COG2215@1|root,COG2215@2|Bacteria,1R3QK@1224|Proteobacteria	1224|Proteobacteria	S	Belongs to the NiCoT transporter (TC 2.A.52) family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1871508_1	1121405.dsmv_3070	2.32e-109	323.0	COG0765@1|root,COG0765@2|Bacteria,1MX3E@1224|Proteobacteria,42N9B@68525|delta/epsilon subdivisions,2WIYW@28221|Deltaproteobacteria,2MJ3R@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1,SBP_bac_3
k59_1871508_2	1265505.ATUG01000001_gene4435	6.88e-12	63.9	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,42M0S@68525|delta/epsilon subdivisions,2WITR@28221|Deltaproteobacteria,2MICA@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ABC transporter	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
k59_1735560_1	768671.ThimaDRAFT_4122	9.65e-08	55.1	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,1S08E@1236|Gammaproteobacteria,1WXTS@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_1735560_2	1177179.A11A3_07043	3.72e-41	147.0	COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,1S739@1236|Gammaproteobacteria,1XKC3@135619|Oceanospirillales	135619|Oceanospirillales	D	COG1192 ATPases involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
k59_109974_1	671143.DAMO_2373	2.41e-127	376.0	COG1012@1|root,COG1012@2|Bacteria,2NNW6@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.9	ko:K00131	ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200	M00308,M00633	R01058	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_51831_1	485913.Krac_5920	2.57e-95	293.0	COG0641@1|root,COG0641@2|Bacteria,2G74V@200795|Chloroflexi	200795|Chloroflexi	C	Iron-sulfur cluster-binding domain	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Radical_SAM,SPASM
k59_1792219_1	400682.PAC_15711180	3.37e-25	101.0	COG0277@1|root,KOG1231@2759|Eukaryota,3AP0I@33154|Opisthokonta	33154|Opisthokonta	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
k59_1792220_1	400668.Mmwyl1_0755	3.17e-47	164.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,1XI99@135619|Oceanospirillales	135619|Oceanospirillales	L	glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
k59_1871529_1	426114.THI_3689	8.3e-30	118.0	COG2251@1|root,COG2251@2|Bacteria,1QUUG@1224|Proteobacteria,2W0DD@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function(DUF2779)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2779
k59_1443307_1	686340.Metal_3671	3.22e-23	98.2	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1XE0U@135618|Methylococcales	135618|Methylococcales	E	Belongs to the peptidase M24B family	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_1443307_2	768671.ThimaDRAFT_1413	2.88e-38	137.0	COG3079@1|root,COG3079@2|Bacteria,1N7W0@1224|Proteobacteria,1SCPW@1236|Gammaproteobacteria,1WYR7@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0149 family	-	-	-	ko:K09895	-	-	-	-	ko00000	-	-	-	UPF0149
k59_502915_1	114615.BRADO0311	2.62e-34	132.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2TRZU@28211|Alphaproteobacteria,3JU6C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CH	TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family	ubiH	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_1617451_1	864051.BurJ1DRAFT_3909	9.85e-76	243.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2VHJB@28216|Betaproteobacteria,1KJ14@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	D-galactarate dehydratase Altronate hydrolase	uxaA	-	4.2.1.7,4.4.1.24	ko:K01685,ko:K16846	ko00040,ko00270,ko01100,map00040,map00270,map01100	M00631	R01540,R07633	RC00543,RC01785	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
k59_403520_1	1223521.BBJX01000014_gene305	1.96e-103	304.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHCD@28216|Betaproteobacteria,4ACDR@80864|Comamonadaceae	28216|Betaproteobacteria	O	Belongs to the GST superfamily	-	-	2.5.1.18	ko:K00799,ko:K11209	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N
k59_444295_1	1026882.MAMP_01346	1.4e-38	140.0	COG2925@1|root,COG2925@2|Bacteria,1MV0U@1224|Proteobacteria,1RM85@1236|Gammaproteobacteria,4601T@72273|Thiotrichales	72273|Thiotrichales	L	Exonuclease C-terminal	sbcB	-	3.1.11.1	ko:K01141	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_X-T_C,RNase_T
k59_620151_1	713587.THITH_11715	3.99e-16	84.3	COG0526@1|root,COG0526@2|Bacteria,1MWDE@1224|Proteobacteria,1S0NV@1236|Gammaproteobacteria,1WXDD@135613|Chromatiales	135613|Chromatiales	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
k59_561541_1	204669.Acid345_2278	6.29e-112	334.0	COG2021@1|root,COG2021@2|Bacteria,3Y2FF@57723|Acidobacteria,2JHN8@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM alpha beta hydrolase	-	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_1343368_1	509190.Cseg_1483	8.96e-77	260.0	COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2KFWJ@204458|Caulobacterales	204458|Caulobacterales	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_152512_3	395493.BegalDRAFT_2182	0.000108	44.7	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,4601I@72273|Thiotrichales	72273|Thiotrichales	C	TIGRFAM cytochrome c oxidase accessory protein FixG	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
k59_53030_1	1333998.M2A_3180	2.92e-78	245.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria,4BQ2U@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	KQ	helix_turn_helix, Arsenical Resistance Operon Repressor	arsR	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Methyltransf_11,Methyltransf_31
k59_1872963_1	1507.HMPREF0262_03096	5.52e-31	119.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,36DUE@31979|Clostridiaceae	186801|Clostridia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_1872963_2	1454004.AW11_03664	4.93e-07	50.4	COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,2VTYZ@28216|Betaproteobacteria,1KR1I@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
k59_53031_1	1317122.ATO12_23835	2.26e-17	82.8	COG5000@1|root,COG5000@2|Bacteria,4NEWF@976|Bacteroidetes,1HYPN@117743|Flavobacteriia,2YGNU@290174|Aquimarina	976|Bacteroidetes	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_8
k59_53031_2	1340434.AXVA01000012_gene3057	1.85e-07	52.4	COG4585@1|root,COG4585@2|Bacteria,1UNJA@1239|Firmicutes,4IUGA@91061|Bacilli,1ZSG5@1386|Bacillus	91061|Bacilli	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_3,PAS_9
k59_1679170_2	1207063.P24_08759	1.13e-24	107.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria,2JPTB@204441|Rhodospirillales	204441|Rhodospirillales	MU	Secretion system type I outer membrane efflux pump lipoprotein NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
k59_992516_1	682795.AciX8_0551	7.38e-18	82.4	COG0704@1|root,COG0704@2|Bacteria,3Y4DI@57723|Acidobacteria,2JJ5M@204432|Acidobacteriia	204432|Acidobacteriia	P	Plays a role in the regulation of phosphate uptake	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_1344771_1	713586.KB900536_gene621	4.95e-16	73.2	2EIMJ@1|root,33CCU@2|Bacteria,1NMXZ@1224|Proteobacteria,1SHQA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_217512_2	411466.ACTODO_01709	5.06e-68	207.0	COG0316@1|root,COG0316@2|Bacteria,2IHR0@201174|Actinobacteria,4D5RP@85005|Actinomycetales	201174|Actinobacteria	S	Belongs to the HesB IscA family	iscA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0071944,GO:1901564	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
k59_217512_3	1454010.JEOE01000002_gene432	3.38e-30	117.0	COG0379@1|root,COG0379@2|Bacteria,2GM59@201174|Actinobacteria,4F0DY@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
k59_1451125_1	1283300.ATXB01000001_gene77	6.09e-46	160.0	28I4Y@1|root,2Z88D@2|Bacteria,1R95V@1224|Proteobacteria,1RRZA@1236|Gammaproteobacteria,1XGQC@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1451125_2	869213.JCM21142_72630	1.05e-20	91.3	COG0004@1|root,COG0004@2|Bacteria,4NDV2@976|Bacteroidetes,47K09@768503|Cytophagia	976|Bacteroidetes	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_335530_1	595536.ADVE02000001_gene3945	9.69e-34	125.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,36Y4V@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_1151945_1	243231.GSU2792	4.96e-74	231.0	COG0500@1|root,COG0500@2|Bacteria,1QW0F@1224|Proteobacteria,43C56@68525|delta/epsilon subdivisions,2X7FJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_1686103_1	710685.MycrhN_1257	1.81e-09	63.5	COG2234@1|root,COG2234@2|Bacteria,2HEN8@201174|Actinobacteria,235II@1762|Mycobacteriaceae	201174|Actinobacteria	S	Peptidase, M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_335534_1	335541.Swol_0585	8.31e-12	67.0	COG1438@1|root,COG1438@2|Bacteria,1V1R7@1239|Firmicutes,24HGQ@186801|Clostridia,42KQ9@68298|Syntrophomonadaceae	186801|Clostridia	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
k59_863094_1	211165.AJLN01000100_gene4089	1.6e-13	75.1	COG4221@1|root,COG4221@2|Bacteria,1GK8Z@1117|Cyanobacteria,1JKMT@1189|Stigonemataceae	1117|Cyanobacteria	S	Domain of unknown function (DUF4336)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4336
k59_510988_1	1496688.ER33_15025	1.61e-110	341.0	COG3119@1|root,COG3119@2|Bacteria,1G3QV@1117|Cyanobacteria,22S9P@167375|Cyanobium	1117|Cyanobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_797422_1	216594.MMAR_2734	3.34e-173	498.0	COG0446@1|root,COG0446@2|Bacteria,2IB5R@201174|Actinobacteria,23756@1762|Mycobacteriaceae	201174|Actinobacteria	S	but shows high identity with sulfide-quinone reductase from chlorobium tepidum	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1215868_1	471853.Bcav_3600	2.25e-73	233.0	COG0151@1|root,COG0151@2|Bacteria,2I2F5@201174|Actinobacteria	201174|Actinobacteria	F	Belongs to the GarS family	purD	GO:0008150,GO:0040007	6.3.3.1,6.3.4.13	ko:K01945,ko:K11788	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208	RC00090,RC00166,RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
k59_746311_2	1283300.ATXB01000001_gene788	2.51e-07	55.1	2BFY8@1|root,329TX@2|Bacteria,1R582@1224|Proteobacteria,1RY97@1236|Gammaproteobacteria,1XER1@135618|Methylococcales	135618|Methylococcales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
k59_452289_1	237368.SCABRO_01042	3.59e-29	119.0	COG0272@1|root,COG0272@2|Bacteria,2IXIC@203682|Planctomycetes	203682|Planctomycetes	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_335573_1	765913.ThidrDRAFT_0782	6.36e-32	115.0	2C9YS@1|root,32SPV@2|Bacteria,1MZQ6@1224|Proteobacteria,1SAFI@1236|Gammaproteobacteria,1WYYN@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1624962_1	456442.Mboo_2091	2.75e-87	276.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,2N91I@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
k59_1624964_1	371731.Rsw2DRAFT_1852	1.08e-71	228.0	COG0095@1|root,COG0095@2|Bacteria,1N1T8@1224|Proteobacteria,2U1PC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_1451186_1	882.DVU_3067	3.56e-50	184.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2WJ51@28221|Deltaproteobacteria,2M8IT@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	iAF987.Gmet_0119	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_159351_1	472759.Nhal_1430	6.02e-208	585.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1WWNU@135613|Chromatiales	135613|Chromatiales	E	PFAM Aminotransferase class-III	-	-	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_570758_2	765912.Thimo_0382	6.22e-157	456.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1WWDG@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1110093_1	243233.MCA1687	4.91e-37	141.0	COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,1RXZ7@1236|Gammaproteobacteria,1XE3M@135618|Methylococcales	135618|Methylococcales	S	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
k59_512332_1	314278.NB231_10753	1.89e-91	276.0	COG3568@1|root,COG3568@2|Bacteria,1RBWV@1224|Proteobacteria,1S296@1236|Gammaproteobacteria,1X2D7@135613|Chromatiales	135613|Chromatiales	L	Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_1392458_1	935863.AWZR01000007_gene324	1.83e-94	283.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,1RMTR@1236|Gammaproteobacteria,1X399@135614|Xanthomonadales	135614|Xanthomonadales	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rmlA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_1518857_1	457570.Nther_2723	3.16e-25	108.0	COG1757@1|root,COG1757@2|Bacteria,1TQ3B@1239|Firmicutes,248WN@186801|Clostridia	186801|Clostridia	C	Na H antiporter	-	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
k59_1217368_1	631362.Thi970DRAFT_00630	6.88e-39	137.0	2DNYF@1|root,32ZSU@2|Bacteria,1N8ZB@1224|Proteobacteria,1S5ZH@1236|Gammaproteobacteria,1WYS0@135613|Chromatiales	135613|Chromatiales	S	PFAM HupH hydrogenase expression protein, C-terminal conserved region	-	-	-	ko:K03618	-	-	-	-	ko00000	-	-	-	HupH_C
k59_512347_2	583355.Caka_2630	3.46e-37	129.0	2E57Z@1|root,3300G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1687624_1	76114.ebA362	3.96e-91	286.0	COG3540@1|root,COG3540@2|Bacteria,1NE6K@1224|Proteobacteria,2WBDQ@28216|Betaproteobacteria,2KY4F@206389|Rhodocyclales	206389|Rhodocyclales	P	PhoD-like phosphatase	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD
k59_1036714_1	590998.Celf_3566	1.42e-24	103.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4F0UZ@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_453644_1	1429916.X566_11190	4.45e-81	251.0	COG1960@1|root,COG1960@2|Bacteria,1MW0F@1224|Proteobacteria,2TR9I@28211|Alphaproteobacteria,3JUIJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	MA20_40060	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1110162_2	1487953.JMKF01000053_gene1864	6.49e-14	74.7	COG1208@1|root,COG1208@2|Bacteria,1G168@1117|Cyanobacteria,1H7P3@1150|Oscillatoriales	1117|Cyanobacteria	JM	Catalyzes the formation of UDP-glucose, from UTP and glucose 1-phosphate	cugP	GO:0000166,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0003983,GO:0005488,GO:0006011,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009225,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0051748,GO:0055086,GO:0070569,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363	2.7.7.13,5.4.2.8	ko:K00966,ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00361,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
k59_1036726_1	1244528.CFT03427_1365	6.84e-39	144.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,42MJR@68525|delta/epsilon subdivisions,2YMAJ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	Heptosyltransferase III	waaQ	-	-	ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_512371_1	909663.KI867150_gene711	3.51e-47	162.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,43A29@68525|delta/epsilon subdivisions,2X21K@28221|Deltaproteobacteria,2MS4J@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	-	-	-	-	-	-	-	-	-	-	FKBP_C
k59_1687651_2	570268.ANBB01000002_gene234	1.55e-06	52.0	COG1999@1|root,COG1999@2|Bacteria,2GKF0@201174|Actinobacteria,4EP2X@85012|Streptosporangiales	201174|Actinobacteria	S	SCO1/SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
k59_337062_1	396588.Tgr7_0247	9.38e-78	237.0	COG1544@1|root,COG1544@2|Bacteria,1RJ55@1224|Proteobacteria,1S5AA@1236|Gammaproteobacteria,1X0WB@135613|Chromatiales	135613|Chromatiales	J	PFAM Cold-shock protein, DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
k59_629781_1	765911.Thivi_0479	1.64e-50	167.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1WW3W@135613|Chromatiales	135613|Chromatiales	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_629781_2	765913.ThidrDRAFT_0351	1.8e-77	243.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1WX7X@135613|Chromatiales	135613|Chromatiales	J	SAM-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
k59_1745386_1	2340.JV46_03710	2.43e-76	247.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1J4WR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1800290_1	1140.Synpcc7942_1885	2.47e-36	129.0	COG0637@1|root,COG0637@2|Bacteria,1G2T2@1117|Cyanobacteria,1GZ2D@1129|Synechococcus	1117|Cyanobacteria	S	HAD-superfamily hydrolase subfamily IA, variant 3	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_1800290_2	1049564.TevJSym_ac01410	2.15e-49	160.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,1J63Q@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression	dksA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
k59_1036751_1	1306174.JODP01000002_gene5760	3.69e-08	53.5	2ECBY@1|root,336AB@2|Bacteria,2GXKR@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1036751_2	471853.Bcav_2250	3.58e-32	120.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria	201174|Actinobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1745400_1	1121035.AUCH01000001_gene1801	1.76e-62	205.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2VH97@28216|Betaproteobacteria,2KVRT@206389|Rhodocyclales	206389|Rhodocyclales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
k59_1687679_2	497964.CfE428DRAFT_3654	2.15e-41	143.0	COG0576@1|root,COG0576@2|Bacteria,46T79@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_1800304_1	1123073.KB899242_gene1352	1.95e-34	130.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,1RNV5@1236|Gammaproteobacteria,1X4BD@135614|Xanthomonadales	135614|Xanthomonadales	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1800304_2	269799.Gmet_3291	2.29e-46	157.0	COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,42S4C@68525|delta/epsilon subdivisions,2WNXY@28221|Deltaproteobacteria,43T1V@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_1568407_1	765910.MARPU_12015	1.15e-79	244.0	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,1RNVU@1236|Gammaproteobacteria,1WVUJ@135613|Chromatiales	135613|Chromatiales	C	PFAM MazG nucleotide pyrophosphohydrolase	mazG	-	3.6.1.9	ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000	-	-	-	MazG
k59_1110228_1	1283300.ATXB01000001_gene1161	1.18e-34	126.0	COG2878@1|root,COG2878@2|Bacteria,1RE44@1224|Proteobacteria,1S5MU@1236|Gammaproteobacteria,1XF1N@135618|Methylococcales	135618|Methylococcales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4_21
k59_1110228_2	1250005.PHEL85_1694	2.3e-20	90.5	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,4NF4F@976|Bacteroidetes,1HXEG@117743|Flavobacteriia	976|Bacteroidetes	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1745403_1	349124.Hhal_1466	3.82e-121	352.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,1RN0Z@1236|Gammaproteobacteria,1WW47@135613|Chromatiales	135613|Chromatiales	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_1800310_1	717785.HYPMC_3220	1.23e-87	274.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TT2C@28211|Alphaproteobacteria,3N64E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	FP	Ppx/GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_747855_1	1123279.ATUS01000001_gene1385	2.92e-72	224.0	COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,1S3XT@1236|Gammaproteobacteria,1J5TG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_689037_1	381666.H16_B0315	1.31e-28	115.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VNB8@28216|Betaproteobacteria,1KGH9@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_689037_2	309800.C498_12493	0.000685	42.0	COG0526@1|root,arCOG00314@2157|Archaea,2XTTJ@28890|Euryarchaeota,23SCQ@183963|Halobacteria	183963|Halobacteria	O	COG0526 Thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_1217437_1	768671.ThimaDRAFT_1939	1.73e-89	275.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,1T5B6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_1217437_2	886293.Sinac_7397	2.5e-85	268.0	COG1861@1|root,COG1861@2|Bacteria,2J3F7@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_1217437_3	522306.CAP2UW1_0195	3.59e-06	47.8	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VNNI@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_747856_1	5016.M2URJ5	6.67e-05	50.4	2D1FQ@1|root,2SHYE@2759|Eukaryota,39T2C@33154|Opisthokonta,3NURP@4751|Fungi,3RJCE@4890|Ascomycota,201CG@147541|Dothideomycetes,4KGB9@92860|Pleosporales	4751|Fungi	G	Belongs to the tannase family	-	-	3.1.1.73	ko:K09252	-	-	-	-	ko00000,ko01000	-	-	-	Tannase
k59_1568431_1	158500.BV97_04532	9.78e-07	54.7	COG0596@1|root,COG0596@2|Bacteria,1N3D5@1224|Proteobacteria,2UCNI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_747858_1	1158050.KB895463_gene3732	2.37e-125	367.0	COG1131@1|root,COG1131@2|Bacteria,2GN8P@201174|Actinobacteria,1WCH5@1268|Micrococcaceae	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_747858_2	1416759.AYMR01000002_gene1807	2.77e-101	310.0	COG2834@1|root,COG2834@2|Bacteria,2GKA2@201174|Actinobacteria,4FMT4@85023|Microbacteriaceae	201174|Actinobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092,MucB_RseB
k59_798480_1	670487.Ocepr_1705	7.32e-55	188.0	COG1173@1|root,COG1173@2|Bacteria,1WI67@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EP	ABC-type dipeptide oligopeptide nickel transport systems, permease components	appC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_1687710_1	1190606.AJYG01000089_gene4505	3.99e-145	424.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,1RNFN@1236|Gammaproteobacteria,1XTUN@135623|Vibrionales	135623|Vibrionales	C	COG1012 NAD-dependent aldehyde dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
k59_453720_1	990285.RGCCGE502_22320	1.02e-36	141.0	COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,2TTBA@28211|Alphaproteobacteria,4BAZE@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_219096_1	357808.RoseRS_3582	5.35e-48	173.0	COG0392@1|root,COG0392@2|Bacteria,2G6NX@200795|Chloroflexi,3765H@32061|Chloroflexia	32061|Chloroflexia	S	PFAM conserved	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
k59_747867_1	1380347.JNII01000006_gene1402	1.88e-16	79.3	COG0500@1|root,COG2226@2|Bacteria,2GNXF@201174|Actinobacteria,4EUV8@85013|Frankiales	201174|Actinobacteria	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	2.1.1.288	ko:K15942	ko01057,ko01130,map01057,map01130	M00781	R06675,R06680	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25,Methyltransf_31
k59_1626619_1	1095767.CAHD01000122_gene2466	8.79e-08	57.0	COG0845@1|root,COG0845@2|Bacteria,2IG0C@201174|Actinobacteria	201174|Actinobacteria	M	HlyD family secretion protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_1626619_2	1121934.AUDX01000005_gene143	1e-51	176.0	COG2021@1|root,COG2021@2|Bacteria,2IMKC@201174|Actinobacteria,4FQP1@85023|Microbacteriaceae	201174|Actinobacteria	E	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Hydrolase_4
k59_747870_1	338969.Rfer_2881	2.77e-59	204.0	COG5492@1|root,COG5492@2|Bacteria,1QY8X@1224|Proteobacteria,2VJ6A@28216|Betaproteobacteria	28216|Betaproteobacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1225836_1	554065.XP_005847195.1	1.2e-70	218.0	COG0065@1|root,KOG0454@2759|Eukaryota	2759|Eukaryota	E	3-isopropylmalate dehydratase activity	-	GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006551,GO:0006790,GO:0006807,GO:0006950,GO:0006970,GO:0006996,GO:0007275,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009628,GO:0009651,GO:0009657,GO:0009658,GO:0009987,GO:0016043,GO:0016053,GO:0016143,GO:0016144,GO:0016829,GO:0016835,GO:0016836,GO:0019748,GO:0019752,GO:0019757,GO:0019758,GO:0019760,GO:0019761,GO:0032501,GO:0032502,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0044550,GO:0046394,GO:0048229,GO:0048856,GO:0050896,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657,GO:1901659	4.2.1.170,4.2.1.33,4.2.1.35	ko:K01704,ko:K21359	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_460372_1	882378.RBRH_00818	7.55e-12	65.9	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2VIG0@28216|Betaproteobacteria,1K08J@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_460372_2	1095769.CAHF01000005_gene1615	4.89e-29	108.0	COG3312@1|root,COG3312@2|Bacteria,1NDM1@1224|Proteobacteria,2VWW4@28216|Betaproteobacteria,474QK@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	ATP synthase I chain	atpI	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATP-synt_I
k59_460372_3	1502852.FG94_04765	3.68e-42	147.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,472Q7@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1460801_1	207954.MED92_16385	1.97e-19	87.8	COG1720@1|root,COG1720@2|Bacteria,1MUF0@1224|Proteobacteria,1RPCX@1236|Gammaproteobacteria,1XJPP@135619|Oceanospirillales	135619|Oceanospirillales	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
k59_873963_1	446466.Cfla_1783	4.33e-158	462.0	COG0441@1|root,COG0441@2|Bacteria,2GKTC@201174|Actinobacteria,4F0HP@85016|Cellulomonadaceae	201174|Actinobacteria	J	PFAM tRNA synthetase class II (G H P and S)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
k59_636598_1	1049564.TevJSym_ao00080	3.35e-83	254.0	COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	sugar kinase	adoK	-	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_636598_2	207954.MED92_18353	4.51e-67	208.0	COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,1S21E@1236|Gammaproteobacteria,1XJ5T@135619|Oceanospirillales	135619|Oceanospirillales	H	May be involved in the biosynthesis of molybdopterin	moaB	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
k59_169179_1	713587.THITH_11965	9.15e-22	92.0	2CARE@1|root,2Z8Q5@2|Bacteria,1R7S8@1224|Proteobacteria,1RRAH@1236|Gammaproteobacteria,1WW2H@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM CRISPR-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Cas6
k59_169179_2	1266914.ATUK01000012_gene201	5.85e-24	92.0	2C2HW@1|root,32U3B@2|Bacteria,1N2W5@1224|Proteobacteria,1SA05@1236|Gammaproteobacteria,1WYXJ@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1696150_1	472759.Nhal_2557	4.65e-52	174.0	COG1295@1|root,COG1295@2|Bacteria,1NH82@1224|Proteobacteria,1S3T8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ribonuclease BN	-	-	-	-	-	-	-	-	-	-	-	-	Virul_fac_BrkB
k59_1696150_2	1121943.KB900004_gene2913	1.36e-26	102.0	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	-	-	-	ko:K06191	-	-	-	-	ko00000	-	-	-	GST_N_3,Glutaredoxin
k59_1635375_1	439235.Dalk_4767	9.28e-124	366.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42M8C@68525|delta/epsilon subdivisions,2WJIB@28221|Deltaproteobacteria,2MJ5E@213118|Desulfobacterales	28221|Deltaproteobacteria	K	sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,Sigma54_activat
k59_636613_1	177437.HRM2_00660	3.81e-143	438.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,42P6X@68525|delta/epsilon subdivisions,2WK8U@28221|Deltaproteobacteria,2MN0V@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
k59_1046819_1	857087.Metme_0755	2.23e-45	152.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,1S61A@1236|Gammaproteobacteria,1XF5X@135618|Methylococcales	135618|Methylococcales	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
k59_1752366_1	1121405.dsmv_1426	6.98e-92	277.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42N1R@68525|delta/epsilon subdivisions,2WJ7R@28221|Deltaproteobacteria,2MHWB@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM cysteine synthase A	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_227208_1	929712.KI912613_gene2708	9.73e-06	44.7	COG2026@1|root,COG2026@2|Bacteria,2GRQR@201174|Actinobacteria,4CTZK@84995|Rubrobacteria	84995|Rubrobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
k59_227208_2	479431.Namu_2650	7.4e-22	95.5	COG1680@1|root,COG1680@2|Bacteria,2HF64@201174|Actinobacteria,4EW6D@85013|Frankiales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_696541_1	1392493.JIAB01000001_gene1228	1.48e-45	166.0	COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,2481R@186801|Clostridia,27J6H@186928|unclassified Lachnospiraceae	186801|Clostridia	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_1046838_1	1304865.JAGF01000001_gene1361	3.48e-94	288.0	COG0276@1|root,COG0276@2|Bacteria,2GJTQ@201174|Actinobacteria,4F12R@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
k59_344660_1	384765.SIAM614_01529	1.66e-50	160.0	COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_344660_2	981384.AEYW01000014_gene131	1.45e-84	255.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,4NC5D@97050|Ruegeria	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_227225_1	880072.Desac_0736	4.75e-115	347.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,42PSJ@68525|delta/epsilon subdivisions,2WJDD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	reductase alpha subunit	aprA	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
k59_874028_1	530564.Psta_1256	4.75e-68	221.0	COG0665@1|root,COG0665@2|Bacteria,2IX78@203682|Planctomycetes	203682|Planctomycetes	C	FAD dependent oxidoreductase	-	-	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO
k59_344665_1	1232437.KL662058_gene3950	8.27e-60	204.0	COG0745@1|root,COG1148@1|root,COG0745@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MI9Y@213118|Desulfobacterales	28221|Deltaproteobacteria	CT	NAD(P)-binding Rossmann-like domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FAD_oxidored,Fer4,Fer4_7,NAD_binding_8,Pyr_redox_2,Response_reg
k59_1806962_1	367299.JOEE01000004_gene1201	1.3e-101	304.0	COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria,4FFMX@85021|Intrasporangiaceae	201174|Actinobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_1752388_1	1335757.SPICUR_09410	3.3e-22	95.1	COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,1WWM6@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator	-	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
k59_1046862_1	864051.BurJ1DRAFT_1203	6.48e-46	165.0	COG2317@1|root,COG2317@2|Bacteria,1MW7T@1224|Proteobacteria,2VKEK@28216|Betaproteobacteria,1KKE6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	ctaQ	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
k59_1696217_1	243233.MCA2253	1.37e-223	644.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1XDWG@135618|Methylococcales	135618|Methylococcales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_1696219_1	1005048.CFU_0494	1.04e-56	195.0	COG0526@1|root,COG0526@2|Bacteria,1MWU8@1224|Proteobacteria,2VPNK@28216|Betaproteobacteria,475CR@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2,Thioredoxin_7
k59_518145_1	357804.Ping_1761	1.65e-36	125.0	2DM8H@1|root,32620@2|Bacteria,1NX99@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_518145_2	1140.Synpcc7942_0103	6e-14	70.9	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4,Ank_5
k59_577653_1	208444.JNYY01000001_gene5182	2.11e-27	108.0	COG0604@1|root,COG0604@2|Bacteria,2HHN3@201174|Actinobacteria,4E8RF@85010|Pseudonocardiales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
k59_577653_2	367299.JOEE01000004_gene1302	5.82e-62	194.0	COG1247@1|root,COG1247@2|Bacteria,2I3CR@201174|Actinobacteria,4FFKD@85021|Intrasporangiaceae	201174|Actinobacteria	M	GCN5 family acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1400838_1	1205680.CAKO01000014_gene115	4e-87	268.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2JQCM@204441|Rhodospirillales	204441|Rhodospirillales	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_804753_2	1000565.METUNv1_01925	3.63e-48	161.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2VPCK@28216|Betaproteobacteria,2KVFX@206389|Rhodocyclales	206389|Rhodocyclales	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
k59_169265_1	335543.Sfum_1261	2.01e-58	194.0	COG1533@1|root,COG1533@2|Bacteria,1NWJ9@1224|Proteobacteria,42P30@68525|delta/epsilon subdivisions,2WIPV@28221|Deltaproteobacteria,2MQE9@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	radical SAM domain protein	-	-	4.1.99.14	ko:K03716	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_227267_1	497964.CfE428DRAFT_4312	9.99e-63	204.0	COG1994@1|root,COG1994@2|Bacteria,46VEB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50,Peptidase_M50B
k59_344709_1	768671.ThimaDRAFT_2229	1.04e-119	377.0	COG0439@1|root,COG1984@1|root,COG2049@1|root,COG4770@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,COG4770@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,1WX8J@135613|Chromatiales	135613|Chromatiales	EI	Allophanate hydrolase subunit 1	-	-	6.3.4.6	ko:K01941	ko00220,ko00791,ko01100,map00220,map00791,map01100	-	R00774	RC00378	ko00000,ko00001,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D
k59_1046902_1	1121405.dsmv_2224	9.61e-81	268.0	COG0577@1|root,COG2234@1|root,COG0577@2|Bacteria,COG2234@2|Bacteria,1MVYE@1224|Proteobacteria,42PKN@68525|delta/epsilon subdivisions,2WIWP@28221|Deltaproteobacteria,2MIQI@213118|Desulfobacterales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,PA,Peptidase_M28
k59_1635482_1	1469245.JFBG01000032_gene1376	2.12e-58	192.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1WWA7@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_1460911_1	1234364.AMSF01000075_gene1935	2.02e-43	151.0	COG1418@1|root,COG1418@2|Bacteria,1RH6M@1224|Proteobacteria,1S81F@1236|Gammaproteobacteria,1X5UH@135614|Xanthomonadales	135614|Xanthomonadales	S	mRNA catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_344720_1	1267005.KB911259_gene3828	5.61e-59	202.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,3N62A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Carbamoyl-phosphate synthase L chain ATP-binding	pccA	GO:0003674,GO:0003824,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009374,GO:0009987,GO:0016421,GO:0016874,GO:0016885,GO:0017144,GO:0019752,GO:0019842,GO:0019899,GO:0031406,GO:0031974,GO:0032787,GO:0033218,GO:0033293,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070013,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901681	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_1577480_1	1121918.ARWE01000001_gene3105	8.31e-73	242.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_227296_1	1049564.TevJSym_aj00320	3.32e-61	202.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1J5GI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iAPECO1_1312.APECO1_1898,iECNA114_1301.ECNA114_0081,iECOK1_1307.ECOK1_0089,iECP_1309.ECP_0090,iECS88_1305.ECS88_0091,iECSF_1327.ECSF_0098,iLF82_1304.LF82_1418,iNRG857_1313.NRG857_00450,iUMN146_1321.UM146_23225,iUTI89_1310.UTI89_C0097	Mur_ligase_C,Mur_ligase_M
k59_577690_1	471853.Bcav_3054	5.7e-85	261.0	COG0847@1|root,COG0847@2|Bacteria,2I2KI@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase III	dnaQ2	-	2.7.7.7	ko:K02337,ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_577690_2	446466.Cfla_2585	4.52e-71	228.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2GITZ@201174|Actinobacteria,4F0EC@85016|Cellulomonadaceae	201174|Actinobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006183,GO:0006195,GO:0006204,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009125,GO:0009126,GO:0009127,GO:0009128,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009154,GO:0009156,GO:0009158,GO:0009161,GO:0009163,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009169,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009261,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046037,GO:0046039,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
k59_874113_1	674977.VMC_28650	6.65e-117	346.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1XV0G@135623|Vibrionales	135623|Vibrionales	F	carbamoyl-phosphate synthetase glutamine chain	carA	GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006139,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_1400884_1	1304865.JAGF01000001_gene3938	3.74e-11	62.8	COG1174@1|root,COG1174@2|Bacteria,2GYTC@201174|Actinobacteria,4F2D4@85016|Cellulomonadaceae	201174|Actinobacteria	E	PFAM binding-protein-dependent transport systems inner membrane component	proW	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
k59_1400884_2	593907.Celgi_2362	4.3e-64	203.0	COG1174@1|root,COG1174@2|Bacteria,2GMU0@201174|Actinobacteria,4F1KA@85016|Cellulomonadaceae	201174|Actinobacteria	E	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
k59_696629_1	649743.HMPREF0972_00306	1e-53	180.0	COG4850@1|root,COG4850@2|Bacteria,2GKPS@201174|Actinobacteria,4D4B2@85005|Actinomycetales	201174|Actinobacteria	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF2183
k59_169308_1	1125863.JAFN01000001_gene802	9.27e-82	259.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42MZJ@68525|delta/epsilon subdivisions,2WJK1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_756290_1	85643.Tmz1t_3393	7.14e-44	154.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2VIBN@28216|Betaproteobacteria,2KVXU@206389|Rhodocyclales	206389|Rhodocyclales	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_756290_2	1304883.KI912532_gene1963	5.77e-20	89.0	COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,2VNC8@28216|Betaproteobacteria,2KW79@206389|Rhodocyclales	206389|Rhodocyclales	NU	type 4 pilus biogenesis protein	pilF	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	TPR_16,TPR_2,TPR_8
k59_696633_2	710685.MycrhN_3705	7.49e-11	66.2	2EGCD@1|root,33A46@2|Bacteria,2HHAC@201174|Actinobacteria,239WD@1762|Mycobacteriaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
k59_1635517_1	1121377.KB906407_gene966	2.09e-13	67.8	COG4696@1|root,COG4696@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	XK27_03185	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	Acetyltransf_3,Hydrolase_3,PRA-PH
k59_577702_1	401526.TcarDRAFT_0317	2.85e-82	261.0	COG0591@1|root,COG0591@2|Bacteria,1TPVE@1239|Firmicutes,4H2AJ@909932|Negativicutes	909932|Negativicutes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	putP	-	-	ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21.2	-	-	SSF
k59_577702_2	261292.Nit79A3_3404	8.33e-16	73.9	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	gpmB	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_1400892_1	1305735.JAFT01000005_gene2272	3.57e-64	212.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	MacB_PCD
k59_1226011_1	1045856.EcWSU1_00694	5.34e-37	129.0	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,3X2HJ@547|Enterobacter	1236|Gammaproteobacteria	K	Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
k59_1637209_2	1432055.GLUCORHAEAF1_13510	4.07e-36	132.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2TQQP@28211|Alphaproteobacteria,2JPSN@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
k59_1462444_1	269796.Rru_A3183	8.43e-16	76.6	COG3658@1|root,COG3658@2|Bacteria,1N28F@1224|Proteobacteria,2UCXG@28211|Alphaproteobacteria,2JTS3@204441|Rhodospirillales	204441|Rhodospirillales	C	Dihaem cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	DHC
k59_806293_1	1120919.AUBI01000031_gene2274	3.78e-24	103.0	COG0494@1|root,COG0494@2|Bacteria,1RAFY@1224|Proteobacteria,2U66M@28211|Alphaproteobacteria,2JPXF@204441|Rhodospirillales	204441|Rhodospirillales	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	-	-	-	-	-	-	-	-	-	-	DUF4743,NUDIX
k59_1808682_1	224911.27355554	2.22e-72	226.0	COG0329@1|root,COG0329@2|Bacteria,1MXI1@1224|Proteobacteria,2TTWT@28211|Alphaproteobacteria,3JT10@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EM	Belongs to the DapA family	MA20_04665	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_1227950_1	933262.AXAM01000063_gene620	1.05e-107	320.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MIA8@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1227962_1	331678.Cphamn1_0709	1.85e-104	322.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
k59_1462468_1	1301098.PKB_0118	3.24e-41	154.0	COG0642@1|root,COG0784@1|root,COG0642@2|Bacteria,COG0784@2|Bacteria,1NC9X@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07647,ko:K07678,ko:K20971,ko:K20973,ko:K20974	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00455,M00475,M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	CHASE5,HAMP,HATPase_c,HisKA,Hpt,PAS_4,Response_reg
k59_806307_1	187272.Mlg_0221	2.57e-28	114.0	COG0176@1|root,COG0176@2|Bacteria,1N9G3@1224|Proteobacteria,1T2QT@1236|Gammaproteobacteria,1WWCJ@135613|Chromatiales	135613|Chromatiales	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
k59_698291_1	686340.Metal_3355	4.69e-27	111.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1XDSH@135618|Methylococcales	135618|Methylococcales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_698291_2	1411685.U062_00212	4.04e-36	132.0	COG1595@1|root,COG1595@2|Bacteria,1R9WC@1224|Proteobacteria,1SA30@1236|Gammaproteobacteria,1J6NG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog	rpoE1	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_638235_1	936136.ARRT01000006_gene3932	1.24e-25	112.0	COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9US@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Guanylate_cyc
k59_1637249_1	743299.Acife_2386	6.47e-20	82.8	COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,1S8QZ@1236|Gammaproteobacteria,2ND88@225057|Acidithiobacillales	225057|Acidithiobacillales	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
k59_1637249_2	279714.FuraDRAFT_0497	1.38e-34	123.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2VR35@28216|Betaproteobacteria,2KR8G@206351|Neisseriales	206351|Neisseriales	S	Psort location Cytoplasmic, score 8.96	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
k59_412276_1	196162.Noca_0314	7.84e-05	44.7	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4DP4J@85009|Propionibacteriales	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.3,3.6.3.4,3.6.3.5,3.6.3.54	ko:K01533,ko:K01534,ko:K12954,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3,3.A.3.5,3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_412276_2	1435356.Y013_25475	3.11e-23	98.6	COG4447@1|root,COG4447@2|Bacteria,2GN53@201174|Actinobacteria,4G06I@85025|Nocardiaceae	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
k59_177521_2	1121428.DESHY_160199___1	2.43e-21	92.4	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,24N7H@186801|Clostridia,26269@186807|Peptococcaceae	186801|Clostridia	H	PFAM 5-formyltetrahydrofolate cyclo-ligase	yqgN	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
k59_236457_1	383407.XOC_1154	1.95e-38	133.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,1S3ST@1236|Gammaproteobacteria,1X6FA@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoaC
k59_999509_1	765910.MARPU_05385	2.47e-48	174.0	COG2885@1|root,COG3267@1|root,COG2885@2|Bacteria,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1WXMX@135613|Chromatiales	135613|Chromatiales	U	Type II secretory pathway, component ExeA	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,OmpA
k59_1703815_1	1278307.KB906996_gene2999	2.69e-30	113.0	2E4R1@1|root,32ZJK@2|Bacteria,1N8FZ@1224|Proteobacteria,1SAJ2@1236|Gammaproteobacteria,2QI66@267894|Psychromonadaceae	1236|Gammaproteobacteria	S	Nitrous oxide-stimulated promoter	ygbA	-	-	-	-	-	-	-	-	-	-	-	YgbA_NO
k59_1410256_1	439235.Dalk_1463	2.97e-91	282.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1RJT0@1224|Proteobacteria,43CRQ@68525|delta/epsilon subdivisions,2X7ZB@28221|Deltaproteobacteria,2MPB2@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_1351602_1	857087.Metme_3969	1.19e-08	60.8	COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1XDJP@135618|Methylococcales	135618|Methylococcales	S	PFAM Cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
k59_941674_1	313624.NSP_13300	6.5e-69	213.0	COG0229@1|root,COG0229@2|Bacteria,1G5S6@1117|Cyanobacteria,1HN5R@1161|Nostocales	1117|Cyanobacteria	O	TIGRFAM methionine-R-sulfoxide reductase	-	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
k59_823273_1	1380355.JNIJ01000007_gene3248	2.85e-05	47.4	2DXZN@1|root,347C2@2|Bacteria,1N2QR@1224|Proteobacteria,2UDZZ@28211|Alphaproteobacteria,3K01T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1469057_1	1469607.KK073768_gene307	6.73e-46	160.0	COG3385@1|root,COG3385@2|Bacteria,1G2W3@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_177538_1	1380380.JIAX01000008_gene1793	4.13e-68	227.0	COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria,2TW3I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0025 NhaP-type Na H and K H antiporters	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
k59_354556_2	1232683.ADIMK_3373	5.08e-30	116.0	COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,1RRRE@1236|Gammaproteobacteria,466K6@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Bacterial lipid A biosynthesis acyltransferase	htrB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_647219_1	768671.ThimaDRAFT_4084	1.27e-117	352.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WW5M@135613|Chromatiales	135613|Chromatiales	EH	Anthranilate synthase component I	-	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_61075_1	1121403.AUCV01000001_gene956	8.81e-24	99.8	COG0642@1|root,COG2205@2|Bacteria,1QHXX@1224|Proteobacteria,42NW1@68525|delta/epsilon subdivisions,2WJUF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_61075_2	439235.Dalk_3684	1.23e-24	96.7	COG0071@1|root,COG0071@2|Bacteria,1NA27@1224|Proteobacteria,42VE3@68525|delta/epsilon subdivisions,2WR9Q@28221|Deltaproteobacteria,2MKAV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_354560_2	1121405.dsmv_2156	2.17e-85	264.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,42NUT@68525|delta/epsilon subdivisions,2WKQX@28221|Deltaproteobacteria,2MI5I@213118|Desulfobacterales	28221|Deltaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_647222_1	478741.JAFS01000001_gene1247	6.28e-94	305.0	COG0085@1|root,COG0085@2|Bacteria,46S8Q@74201|Verrucomicrobia,37FZ1@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1469062_1	1454004.AW11_02485	2.01e-94	282.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_1469062_2	1454004.AW11_02486	1.07e-12	66.6	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2VH6Y@28216|Betaproteobacteria	28216|Betaproteobacteria	P	phosphate transport system permease	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_1703840_2	1163409.UUA_03248	3.11e-49	166.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,1X2X5@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_647228_1	1038862.KB893895_gene7170	5.71e-08	53.1	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TSME@28211|Alphaproteobacteria,3JQSX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Gamma-glutamyltranspeptidase	MA20_16750	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_941703_1	639283.Snov_2933	1.46e-17	84.7	COG4566@1|root,COG4566@2|Bacteria,1R47Z@1224|Proteobacteria,2TSQS@28211|Alphaproteobacteria,3EYAG@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	response regulator	nodW	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_883009_1	1380393.JHVP01000007_gene4406	8.54e-22	97.8	28QKY@1|root,2ZD2Q@2|Bacteria,2IM53@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_529794_1	983545.Glaag_3503	4.33e-63	215.0	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,1RMA0@1236|Gammaproteobacteria,465XX@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
k59_883015_1	1713.JOFV01000015_gene1765	4.52e-193	564.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4F0M6@85016|Cellulomonadaceae	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_941711_1	1137799.GZ78_24350	2.75e-57	204.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1XJ5F@135619|Oceanospirillales	135619|Oceanospirillales	NU	Tfp pilus assembly protein tip-associated adhesin PilY1	-	-	-	-	-	-	-	-	-	-	-	-	Neisseria_PilC
k59_1469073_1	1286093.C266_20759	3.05e-19	90.1	2E9FY@1|root,333P7@2|Bacteria,1N8S6@1224|Proteobacteria,2VWAN@28216|Betaproteobacteria,1K7R1@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_61101_2	472759.Nhal_1309	5.74e-141	420.0	COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,1S118@1236|Gammaproteobacteria,1X0F2@135613|Chromatiales	135613|Chromatiales	I	Squalene-hopene cyclase N-terminal domain	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
k59_1951_1	768671.ThimaDRAFT_0726	5.36e-100	305.0	COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,1RXX2@1236|Gammaproteobacteria,1WX24@135613|Chromatiales	135613|Chromatiales	S	VWA-like domain (DUF2201)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2201,DUF2201_N
k59_823294_2	873449.STRCR_1603	6.19e-35	130.0	COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes,4HA1W@91061|Bacilli	91061|Bacilli	G	Belongs to the glycosyl hydrolase 1 family	bglA	-	3.2.1.86	ko:K01223	ko00010,ko00500,map00010,map00500	-	R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000	-	GT1	-	Glyco_hydro_1
k59_1234268_1	641491.DND132_0376	1.73e-43	156.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,42NWZ@68525|delta/epsilon subdivisions,2WJU7@28221|Deltaproteobacteria,2M895@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	TrkA-N domain protein	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_354590_1	177439.DP1202	1.21e-108	330.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,2MHX9@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_471050_1	864702.OsccyDRAFT_1674	3.18e-54	196.0	COG0474@1|root,COG0474@2|Bacteria,1G3BZ@1117|Cyanobacteria,1H8N0@1150|Oscillatoriales	1117|Cyanobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	-	ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.23	-	-	E1-E2_ATPase,Hydrolase
k59_529801_1	471853.Bcav_2428	9.58e-211	607.0	COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria	201174|Actinobacteria	L	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD_C_2,Viral_helicase1
k59_1116831_1	706191.PANA_0196	2.07e-57	187.0	COG0084@1|root,COG0084@2|Bacteria,1MXN8@1224|Proteobacteria,1RNCC@1236|Gammaproteobacteria,3VZAD@53335|Pantoea	1236|Gammaproteobacteria	L	3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair	tatD	GO:0000175,GO:0000302,GO:0000738,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009056,GO:0009057,GO:0009636,GO:0009987,GO:0010035,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046700,GO:0046872,GO:0050896,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901700	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
k59_1116833_1	439235.Dalk_3302	2.08e-110	326.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2MII7@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	PFAM type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_471060_1	393595.ABO_1437	8.45e-70	222.0	COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria,1XHD6@135619|Oceanospirillales	135619|Oceanospirillales	K	in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon	cysB	-	-	ko:K13634	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_589512_1	768671.ThimaDRAFT_2431	6.7e-38	139.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria,1WXHA@135613|Chromatiales	135613|Chromatiales	S	Peptidogalycan biosysnthesis/recognition	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
k59_589512_2	572477.Alvin_2277	1.08e-53	176.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,1WWJ2@135613|Chromatiales	135613|Chromatiales	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
k59_237576_1	1121405.dsmv_0615	8.8e-29	116.0	COG1150@1|root,COG1150@2|Bacteria,1QUKA@1224|Proteobacteria,42MNE@68525|delta/epsilon subdivisions,2WIN3@28221|Deltaproteobacteria,2MHSC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	qmoC	-	-	ko:K16887	-	-	-	-	ko00000	-	-	-	Fer4_17,Fer4_8,Fer4_9,Nitrate_red_gam
k59_1295240_1	1177181.T9A_01332	6.61e-11	61.6	COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,1S8VU@1236|Gammaproteobacteria,1XKFY@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the HSP15 family	hslR	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
k59_413200_1	1380355.JNIJ01000004_gene2827	1.04e-46	163.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria,3JSD0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	MA20_01050	-	1.17.1.10	ko:K15022	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00377	R00134	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3
k59_413200_2	1454004.AW11_01299	6.99e-35	131.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2VIEB@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
k59_1587171_1	631362.Thi970DRAFT_02119	1.76e-159	452.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1WW5R@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
k59_1646331_1	768671.ThimaDRAFT_1318	7.73e-07	50.1	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_1646331_2	1278307.KB906982_gene3980	1.13e-23	102.0	COG0265@1|root,COG0265@2|Bacteria,1RINT@1224|Proteobacteria,1SPC3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
k59_295976_2	1101190.ARWB01000001_gene2024	1.85e-39	134.0	COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,2U9DF@28211|Alphaproteobacteria,36YDJ@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Ribosomal protein L19	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
k59_1295250_1	1122939.ATUD01000009_gene2990	2.61e-32	127.0	COG0466@1|root,COG0466@2|Bacteria,2GK9D@201174|Actinobacteria,4CPC3@84995|Rubrobacteria	84995|Rubrobacteria	O	Found in ATP-dependent protease La (LON)	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1823474_1	522306.CAP2UW1_1243	2.55e-97	320.0	COG0022@1|root,COG0332@1|root,COG0508@1|root,COG1071@1|root,COG0022@2|Bacteria,COG0332@2|Bacteria,COG0508@2|Bacteria,COG1071@2|Bacteria,1MU9N@1224|Proteobacteria,2VI2A@28216|Betaproteobacteria,1KPNJ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH_1	-	1.2.4.4,2.3.1.180	ko:K00648,ko:K11381	ko00061,ko00280,ko00640,ko01100,ko01110,ko01130,ko01212,map00061,map00280,map00640,map01100,map01110,map01130,map01212	M00036,M00082,M00083	R07599,R07600,R07601,R07602,R07603,R07604,R10707,R10996,R10997	RC00004,RC00027,RC00627,RC02729,RC02743,RC02883,RC02888,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_355921_1	1120980.JQKH01000097_gene29	8.01e-20	90.9	COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2VR0Y@28216|Betaproteobacteria,2KPN9@206351|Neisseriales	206351|Neisseriales	M	Belongs to the ompA family	yiaD	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,OmpA,Rick_17kDa_Anti
k59_706928_1	589865.DaAHT2_0418	5.49e-09	63.2	COG5557@1|root,COG5557@2|Bacteria,1R54P@1224|Proteobacteria,42N9S@68525|delta/epsilon subdivisions,2WNKD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_648142_1	1123065.ATWL01000009_gene992	2.85e-38	141.0	COG1192@1|root,COG1192@2|Bacteria,2I44R@201174|Actinobacteria	201174|Actinobacteria	D	Involved in chromosome partitioning	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
k59_237582_2	1469245.JFBG01000019_gene1132	2.53e-102	320.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,1S0DI@1236|Gammaproteobacteria,1X0D5@135613|Chromatiales	135613|Chromatiales	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	ko:K16886	-	-	-	-	ko00000	-	-	-	Fer4,FlpD
k59_589525_1	338969.Rfer_1701	1.69e-87	282.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2VKF8@28216|Betaproteobacteria,4ACQA@80864|Comamonadaceae	28216|Betaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_824055_1	359.CN09_03510	5.31e-96	291.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2UEQQ@28211|Alphaproteobacteria,4BC7V@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,rve,rve_3
k59_237584_1	1499967.BAYZ01000078_gene985	1.34e-99	302.0	COG1541@1|root,COG1541@2|Bacteria,2NREC@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
k59_943063_1	519989.ECTPHS_03929	1.17e-58	189.0	COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,1RQ7W@1236|Gammaproteobacteria,1X286@135613|Chromatiales	135613|Chromatiales	C	Oxidoreductase FAD-binding domain	-	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind
k59_119876_1	1396418.BATQ01000049_gene332	9.13e-60	199.0	COG0318@1|root,COG0318@2|Bacteria,46T7I@74201|Verrucomicrobia,2IVBG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_413210_1	1380394.JADL01000001_gene2792	3.69e-89	276.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria,2JPME@204441|Rhodospirillales	204441|Rhodospirillales	KQ	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Methyltransf_11
k59_413210_2	1054213.HMPREF9946_01325	1.47e-129	377.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2TQZA@28211|Alphaproteobacteria,2JQ95@204441|Rhodospirillales	204441|Rhodospirillales	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
k59_62460_1	56780.SYN_00850	1.5e-11	63.5	COG1309@1|root,COG1309@2|Bacteria,1NDME@1224|Proteobacteria,42MYP@68525|delta/epsilon subdivisions,2WKKZ@28221|Deltaproteobacteria,2MRNP@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Domain of unknown function (DUF1956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1956,TetR_N
k59_1470005_1	471856.Jden_0527	6.83e-46	159.0	COG1575@1|root,COG1575@2|Bacteria,2GJBS@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	GO:0003674,GO:0003824,GO:0004659,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_178530_1	1304865.JAGF01000001_gene659	8.95e-149	438.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,2H7WY@201174|Actinobacteria,4F10M@85016|Cellulomonadaceae	201174|Actinobacteria	P	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	cdr	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
k59_119885_1	42565.FP66_03985	1.65e-74	238.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1XI0Q@135619|Oceanospirillales	135619|Oceanospirillales	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_62471_1	224308.BSU14730	6.39e-06	52.4	COG1595@1|root,COG1595@2|Bacteria,1V1S3@1239|Firmicutes,4HG2H@91061|Bacilli,1ZGKM@1386|Bacillus	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	ylaC	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_355956_1	130081.XP_005708678.1	1.34e-10	67.0	COG0421@1|root,KOG1562@2759|Eukaryota	2759|Eukaryota	E	spermidine synthase activity	SPS1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0008150,GO:0009888,GO:0009914,GO:0009926,GO:0009987,GO:0010087,GO:0010089,GO:0010487,GO:0010817,GO:0016740,GO:0016765,GO:0016768,GO:0030154,GO:0032502,GO:0044424,GO:0044464,GO:0048759,GO:0048856,GO:0048869,GO:0051179,GO:0051234,GO:0060918,GO:0065007,GO:0065008,GO:1905177	2.5.1.79	ko:K18787	-	-	-	-	ko00000,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
k59_884363_1	187272.Mlg_1471	1.21e-83	273.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdZ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_1295288_1	1131814.JAFO01000001_gene2846	1.95e-11	64.3	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,3F1QJ@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
k59_1295288_2	395495.Lcho_1730	8.8e-08	60.1	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,2VJCR@28216|Betaproteobacteria	28216|Betaproteobacteria	T	PFAM GGDEF domain containing protein	-	-	2.7.7.65	ko:K21022	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF
k59_1235270_1	1415778.JQMM01000001_gene2182	2.85e-95	289.0	COG0224@1|root,COG0224@2|Bacteria,1RIE5@1224|Proteobacteria,1S3ZW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	ATP synthase gamma subunit	-	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_472047_1	1163617.SCD_n00183	2.08e-37	135.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_765345_1	95619.PM1_0210870	5.52e-49	165.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7,3.1.26.4	ko:K02342,ko:K14159	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_H,RNase_T
k59_943097_3	870187.Thini_2089	7.43e-38	131.0	COG2010@1|root,COG2010@2|Bacteria,1N91W@1224|Proteobacteria,1SD5N@1236|Gammaproteobacteria,461B4@72273|Thiotrichales	72273|Thiotrichales	C	Cytochrome c	-	-	-	ko:K17223	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_943097_4	870187.Thini_2090	2.48e-08	53.9	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,1S4ZT@1236|Gammaproteobacteria,461A3@72273|Thiotrichales	72273|Thiotrichales	S	Sulfur oxidation protein SoxY	-	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY,TAT_signal
k59_1352604_1	187272.Mlg_1981	1.3e-109	346.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1WVW8@135613|Chromatiales	135613|Chromatiales	EF	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_589559_1	1384056.N787_04060	1.82e-07	53.1	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,1RMK7@1236|Gammaproteobacteria,1X4RW@135614|Xanthomonadales	135614|Xanthomonadales	C	Electron transfer flavoprotein	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
k59_589559_2	1234364.AMSF01000066_gene2270	2.89e-57	185.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,1RN6F@1236|Gammaproteobacteria,1X34D@135614|Xanthomonadales	135614|Xanthomonadales	C	electron transfer flavoprotein beta subunit	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_824085_1	323261.Noc_1208	1.51e-50	170.0	28HJ1@1|root,2Z7UB@2|Bacteria,1R3FN@1224|Proteobacteria,1S37A@1236|Gammaproteobacteria,1WXEJ@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1063672_2	1108045.GORHZ_053_00540	2.16e-63	208.0	COG0471@1|root,COG0471@2|Bacteria,2GVHZ@201174|Actinobacteria,4GD1J@85026|Gordoniaceae	201174|Actinobacteria	P	Sodium:sulfate symporter transmembrane region	sdcS	-	-	ko:K03319,ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47,2.A.47.1	-	-	Na_sulph_symp
k59_362595_1	1122599.AUGR01000018_gene3967	1.78e-51	182.0	COG0591@1|root,COG0591@2|Bacteria,1QX2W@1224|Proteobacteria,1RZNE@1236|Gammaproteobacteria,1XJ1J@135619|Oceanospirillales	135619|Oceanospirillales	EKT	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_711500_1	1267005.KB911257_gene1093	7.66e-142	406.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TQKB@28211|Alphaproteobacteria,3N634@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_594009_2	479431.Namu_1682	3.05e-45	161.0	COG0545@1|root,COG0545@2|Bacteria,2GJK2@201174|Actinobacteria,4ET6I@85013|Frankiales	201174|Actinobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	fkbB	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
k59_1064874_1	1249627.D779_1571	1.37e-32	115.0	2CDMX@1|root,32S1K@2|Bacteria,1N1I8@1224|Proteobacteria,1S9N4@1236|Gammaproteobacteria,1WYR4@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1301999_1	1121405.dsmv_1154	1.65e-64	214.0	COG2433@1|root,COG2433@2|Bacteria,1RE5Q@1224|Proteobacteria,42WSA@68525|delta/epsilon subdivisions,2WRPQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_1475796_1	589865.DaAHT2_0828	4.34e-66	209.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,42MW0@68525|delta/epsilon subdivisions,2WJ90@28221|Deltaproteobacteria,2MHRX@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
k59_1767597_1	1278307.KB906985_gene4308	8.94e-05	49.7	COG4795@1|root,COG4795@2|Bacteria,1RJAE@1224|Proteobacteria,1S5ZZ@1236|Gammaproteobacteria,2QI1U@267894|Psychromonadaceae	1236|Gammaproteobacteria	U	Type II secretion system (T2SS), protein J	gspJ	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSJ
k59_890859_1	313589.JNB_16414	1.04e-99	299.0	COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,4FF8S@85021|Intrasporangiaceae	201174|Actinobacteria	C	alcohol dehydrogenase	adhC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.306	ko:K00153	-	-	R09129,R10301	RC00069,RC01715	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_362607_1	29306.JOBE01000010_gene7091	8.71e-129	376.0	COG3384@1|root,COG3384@2|Bacteria,2GNCA@201174|Actinobacteria	201174|Actinobacteria	S	Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively	-	-	1.13.11.57,1.13.11.8	ko:K04099,ko:K04101	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigA,LigB
k59_1064884_1	1123399.AQVE01000019_gene1570	3.79e-97	308.0	COG4191@1|root,COG4191@2|Bacteria,1R969@1224|Proteobacteria	1224|Proteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_8
k59_1240809_1	323261.Noc_0887	1.17e-59	186.0	COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,1S66E@1236|Gammaproteobacteria,1WY82@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
k59_890865_1	998674.ATTE01000001_gene2444	6.31e-78	238.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria,460HZ@72273|Thiotrichales	72273|Thiotrichales	O	Stringent starvation protein A	-	-	-	ko:K03599	-	-	-	-	ko00000,ko02000,ko03021	1.A.12.3.1	-	-	GST_C,GST_N_3
k59_890865_2	1049564.TevJSym_ag00070	1.43e-60	194.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1J7JW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Cytochrome C1 family	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
k59_711516_2	996637.SGM_4306	7.52e-44	157.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria	201174|Actinobacteria	O	associated with various cellular activities	clpC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
k59_890871_1	536019.Mesop_0765	1.71e-25	110.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2U37P@28211|Alphaproteobacteria,43MPR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8,Trans_reg_C
k59_769097_1	926549.KI421517_gene2597	2.06e-55	191.0	COG1217@1|root,COG1217@2|Bacteria,4NDVM@976|Bacteroidetes,47KWA@768503|Cytophagia	976|Bacteroidetes	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_1064902_1	1049564.TevJSym_ag00880	2.22e-175	505.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,1RZ0U@1236|Gammaproteobacteria,1JAJ9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Fumarate reductase flavoprotein C-term	aprA	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1767609_1	1035308.AQYY01000001_gene1742	1.08e-85	266.0	COG3642@1|root,COG3642@2|Bacteria	2|Bacteria	T	kinase activity	inaA	-	-	ko:K02848	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DUF4032,Kdo
k59_1181246_1	471853.Bcav_3870	1.47e-81	249.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1830165_1	590998.Celf_2482	4.59e-63	207.0	COG0499@1|root,COG0499@2|Bacteria,2GK2Q@201174|Actinobacteria,4F0EM@85016|Cellulomonadaceae	201174|Actinobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0000098,GO:0000166,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009087,GO:0009116,GO:0009119,GO:0009987,GO:0016020,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0019899,GO:0022610,GO:0030260,GO:0030312,GO:0033353,GO:0034641,GO:0035375,GO:0035635,GO:0036094,GO:0040007,GO:0042278,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044650,GO:0046085,GO:0046128,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0048037,GO:0050662,GO:0051186,GO:0051287,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0055086,GO:0070403,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_1830165_2	446466.Cfla_2420	7e-15	82.0	COG3206@1|root,COG3206@2|Bacteria,2GPMH@201174|Actinobacteria,4F2H2@85016|Cellulomonadaceae	201174|Actinobacteria	M	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
k59_1651073_1	1288494.EBAPG3_14810	1.32e-112	335.0	COG0676@1|root,COG0676@2|Bacteria,1Q7VN@1224|Proteobacteria,2VKZK@28216|Betaproteobacteria,372TP@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Belongs to the glucose-6-phosphate 1-epimerase family	-	-	5.1.3.15	ko:K01792	ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130	-	R02739	RC00563	ko00000,ko00001,ko01000	-	-	-	Aldose_epim
k59_244670_1	1123065.ATWL01000005_gene1288	6.79e-32	120.0	COG3247@1|root,COG3247@2|Bacteria	2|Bacteria	U	response to pH	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
k59_1709208_1	525246.HMPREF0058_0354	9.67e-79	246.0	COG0107@1|root,COG0107@2|Bacteria,2GIRP@201174|Actinobacteria,4D3BI@85005|Actinomycetales	201174|Actinobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0008150,GO:0016740,GO:0016757,GO:0016763,GO:0040007	4.1.3.27	ko:K01657,ko:K02500	ko00340,ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00340,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023,M00026	R00985,R00986,R04558	RC00010,RC01190,RC01943,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_652882_1	1226994.AMZB01000083_gene333	1.02e-75	234.0	COG1177@1|root,COG1177@2|Bacteria,1N3TB@1224|Proteobacteria,1RP67@1236|Gammaproteobacteria,1YDTB@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
k59_124519_1	247634.GPB2148_2941	2.1e-79	254.0	COG4865@1|root,COG4865@2|Bacteria,1PCBW@1224|Proteobacteria,1RS7U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate)	glmE	-	5.4.99.1	ko:K19268	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R00262	RC01221	ko00000,ko00001,ko00002,ko01000	-	-	-	Met_asp_mut_E
k59_124519_2	246194.CHY_0307	2.47e-33	121.0	COG2185@1|root,COG2185@2|Bacteria,1V45Q@1239|Firmicutes,24HGC@186801|Clostridia,42GMZ@68295|Thermoanaerobacterales	186801|Clostridia	I	Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate)	mamA	-	5.4.99.1	ko:K01846	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R00262	RC01221	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
k59_1121399_1	269799.Gmet_1349	9.55e-29	119.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,42MD4@68525|delta/epsilon subdivisions,2WJ7Z@28221|Deltaproteobacteria,43S5U@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	TIGRFAM ATP-dependent helicase HrpB	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_1591503_1	2340.JV46_23520	1e-17	81.6	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1J4QP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_1357125_1	1123267.JONN01000001_gene1214	2.53e-18	90.5	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2TQTB@28211|Alphaproteobacteria,2K01N@204457|Sphingomonadales	204457|Sphingomonadales	T	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
k59_1357125_2	1249627.D779_1368	4.29e-108	326.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1WXC2@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_244683_1	243233.MCA1346	2.75e-94	285.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,1RP2I@1236|Gammaproteobacteria,1XF21@135618|Methylococcales	135618|Methylococcales	P	PFAM Bile acid sodium symporter	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
k59_1240845_1	590998.Celf_2244	6.21e-54	177.0	COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,4F0G4@85016|Cellulomonadaceae	201174|Actinobacteria	GK	ROK family	ppgK	-	2.7.1.2,2.7.1.63	ko:K00845,ko:K00886	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786,R02187,R02189	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_711539_1	1122201.AUAZ01000004_gene3394	4.12e-14	70.9	COG0732@1|root,COG5113@1|root,COG0732@2|Bacteria,COG3236@2|Bacteria,1Q4FB@1224|Proteobacteria,1RS7D@1236|Gammaproteobacteria,46823@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	restriction modification system DNA specificity	hsdS	-	3.1.21.3	ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
k59_711539_2	207559.Dde_1861	1.89e-06	50.4	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,42MUF@68525|delta/epsilon subdivisions,2WK25@28221|Deltaproteobacteria,2MGDJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	DNA methylase	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
k59_711539_3	207559.Dde_1858	1.09e-61	198.0	COG1715@1|root,COG1715@2|Bacteria,1R4NQ@1224|Proteobacteria,43B1F@68525|delta/epsilon subdivisions,2X6FN@28221|Deltaproteobacteria,2MH2I@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	HB1, ASXL, restriction endonuclease HTH domain	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	HARE-HTH,Mrr_cat
k59_1591506_1	1187851.A33M_3367	2.2e-55	186.0	COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,2TS4G@28211|Alphaproteobacteria,3FCZF@34008|Rhodovulum	28211|Alphaproteobacteria	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
k59_652890_1	1049564.TevJSym_an00030	9.44e-165	476.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1J7AF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	5'-nucleotidase, C-terminal domain	soxB	-	-	ko:K17224	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	5_nucleotid_C
k59_1004050_1	1123401.JHYQ01000013_gene653	0.000185	48.9	28T0P@1|root,2ZF9Z@2|Bacteria,1RAUV@1224|Proteobacteria,1S23D@1236|Gammaproteobacteria,463DR@72273|Thiotrichales	72273|Thiotrichales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1004050_2	1353528.DT23_14505	8.91e-09	56.2	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2TTS5@28211|Alphaproteobacteria,2XPHN@285107|Thioclava	28211|Alphaproteobacteria	S	4Fe-4S single cluster domain	nirJ	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_1767624_1	264198.Reut_A1203	3.82e-39	142.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2VHRC@28216|Betaproteobacteria,1K1WI@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
k59_1767624_2	159087.Daro_2098	1.56e-07	52.8	COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2WGKC@28216|Betaproteobacteria,2KV8I@206389|Rhodocyclales	28216|Betaproteobacteria	CI	Bifunctional enoyl-CoA hydratase phosphate acetyltransferase	-	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas,PTA_PTB
k59_1240854_1	1249627.D779_2395	4.44e-135	392.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,1RNHI@1236|Gammaproteobacteria,1WX2H@135613|Chromatiales	135613|Chromatiales	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
k59_711547_1	323848.Nmul_A2213	1.74e-07	56.6	COG3209@1|root,COG3209@2|Bacteria,1N9RU@1224|Proteobacteria,2WEQE@28216|Betaproteobacteria	28216|Betaproteobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_362663_1	882083.SacmaDRAFT_4805	1.3e-27	111.0	COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria,4DXU7@85010|Pseudonocardiales	201174|Actinobacteria	H	TIGRFAM molybdenum cofactor synthesis domain	moeA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_362663_2	2055.JNXA01000024_gene3929	4.25e-13	74.3	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2GJB6@201174|Actinobacteria,4GAUG@85026|Gordoniaceae	201174|Actinobacteria	HP	ThiF family	moeB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0019344,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
k59_1651099_1	1280390.CBQR020000098_gene2207	4.28e-63	211.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,4HA95@91061|Bacilli,26Q94@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_244715_1	1201035.KE007211_gene440	2.09e-64	211.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2TRP9@28211|Alphaproteobacteria,48TA3@772|Bartonellaceae	28211|Alphaproteobacteria	P	TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_1064971_1	1304885.AUEY01000022_gene3413	2.52e-23	103.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2MHZN@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
k59_1533078_1	391615.ABSJ01000026_gene84	8.38e-59	196.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1J4Z7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Isocitrate	icd	GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJN746.PP_4011,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144	Iso_dh
k59_1121418_1	1304872.JAGC01000009_gene1362	3.7e-82	251.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,42MNQ@68525|delta/epsilon subdivisions,2WJJW@28221|Deltaproteobacteria,2M869@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_2942	tRNA-synt_2e
k59_417764_1	1111131.HMPREF1255_0639	1.54e-30	119.0	COG0008@1|root,COG0008@2|Bacteria,2H1TZ@201174|Actinobacteria	201174|Actinobacteria	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
k59_417764_2	351607.Acel_0714	1.08e-48	168.0	COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria,4ERZ8@85013|Frankiales	201174|Actinobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_476649_1	398525.KB900701_gene4123	7.45e-23	102.0	COG1145@1|root,COG2221@1|root,COG1145@2|Bacteria,COG2221@2|Bacteria,1MWHY@1224|Proteobacteria,2TS71@28211|Alphaproteobacteria,3JSPD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
k59_949894_1	314271.RB2654_03834	3.63e-07	54.7	COG1275@1|root,COG1275@2|Bacteria,1MVPG@1224|Proteobacteria,2U072@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	C4-dicarboxylate transporter malic acid transport protein	tehA	-	-	ko:K03304	-	-	-	-	ko00000,ko02000	2.A.16.1	-	-	SLAC1
k59_949894_2	1454010.JEOE01000003_gene337	3.59e-99	303.0	COG1808@1|root,COG1808@2|Bacteria,2HXWI@201174|Actinobacteria,4F1B5@85016|Cellulomonadaceae	201174|Actinobacteria	S	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
k59_949894_3	471853.Bcav_0742	1.21e-09	58.5	2CA7I@1|root,30E5G@2|Bacteria,2IJ78@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1240881_1	1519464.HY22_11575	1.05e-45	160.0	COG0026@1|root,COG0026@2|Bacteria,1FFR3@1090|Chlorobi	1090|Chlorobi	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
k59_949896_1	414684.RC1_0236	3.57e-101	310.0	COG3573@1|root,COG3573@2|Bacteria,1R00Y@1224|Proteobacteria	1224|Proteobacteria	C	FAD dependent oxidoreductase	-	-	-	ko:K07077	-	-	-	-	ko00000	-	-	-	FAD_binding_2
k59_711568_1	1170562.Cal6303_0530	8.37e-16	79.0	COG0212@1|root,COG0212@2|Bacteria,1G2B2@1117|Cyanobacteria,1HKTF@1161|Nostocales	1117|Cyanobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_711568_2	1496688.ER33_15015	2.5e-29	112.0	COG2326@1|root,COG2326@2|Bacteria,1G159@1117|Cyanobacteria,22TKN@167375|Cyanobium	1117|Cyanobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_11005_1	1049564.TevJSym_be00050	1.35e-103	307.0	COG1242@1|root,COG1242@2|Bacteria,1MUYF@1224|Proteobacteria,1RP94@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	radical SAM protein	yhcC	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051539,GO:0051540	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
k59_1302095_1	1123279.ATUS01000001_gene2323	9.8e-99	297.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1J4V0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048	Formyl_trans_C,Formyl_trans_N
k59_476656_1	1224318.DT73_22845	1.19e-63	209.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,1RNQI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GM	Belongs to the mannose-6-phosphate isomerase type 2 family	cpsB	GO:0000271,GO:0003674,GO:0003824,GO:0004475,GO:0005975,GO:0005976,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008905,GO:0008928,GO:0009058,GO:0009059,GO:0009242,GO:0009628,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046377,GO:0050896,GO:0070568,GO:0071704,GO:1901135,GO:1901137,GO:1901576	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	iE2348C_1286.E2348C_2191,iEC042_1314.EC042_2286,iECIAI1_1343.ECIAI1_2124,iECO26_1355.ECO26_2960,iECSE_1348.ECSE_2323,iECW_1372.ECW_m2206,iEKO11_1354.EKO11_1746,iEcE24377_1341.EcE24377A_2342,iLF82_1304.LF82_0345,iNRG857_1313.NRG857_10420,iWFL_1372.ECW_m2206	MannoseP_isomer,NTP_transferase
k59_1240893_1	1521187.JPIM01000232_gene2766	8.51e-09	57.0	COG0714@1|root,COG0714@2|Bacteria,2G66D@200795|Chloroflexi,374V5@32061|Chloroflexia	32061|Chloroflexia	S	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_417783_2	278957.ABEA03000060_gene3093	2.51e-16	79.0	COG0468@1|root,COG0468@2|Bacteria,46SIZ@74201|Verrucomicrobia,3K737@414999|Opitutae	414999|Opitutae	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_1181304_1	1173027.Mic7113_2435	1.18e-50	182.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M6@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4
k59_890944_1	85643.Tmz1t_3557	1.05e-150	434.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,2VQVG@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Methyltransferase type 11	arsM	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
k59_1533096_1	452637.Oter_1488	1.31e-123	368.0	COG0554@1|root,COG0554@2|Bacteria,46SJW@74201|Verrucomicrobia,3K7I5@414999|Opitutae	414999|Opitutae	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_183298_1	314278.NB231_00900	3.51e-81	253.0	COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,1RN1U@1236|Gammaproteobacteria,1WWNF@135613|Chromatiales	135613|Chromatiales	I	Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
k59_362704_1	240015.ACP_2414	1.88e-52	180.0	COG1226@1|root,COG1226@2|Bacteria,3Y4K4@57723|Acidobacteria,2JMIM@204432|Acidobacteriia	204432|Acidobacteriia	P	TrkA-C domain	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
k59_183305_1	467200.ACFA01000313_gene4492	5.19e-60	197.0	COG0604@1|root,COG0604@2|Bacteria,2GMHR@201174|Actinobacteria	201174|Actinobacteria	C	alcohol dehydrogenase	adh3	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
k59_1773435_2	593907.Celgi_0317	7.41e-17	80.9	COG3459@1|root,COG3459@2|Bacteria	2|Bacteria	G	carbohydrate binding	cbpA	-	2.4.1.333	ko:K21298	-	-	-	-	ko00000,ko01000	-	GH94	-	Glyco_hydro_36,Glyco_transf_36
k59_189623_1	1198232.CYCME_0769	8.03e-39	134.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,4601G@72273|Thiotrichales	72273|Thiotrichales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_189623_2	314287.GB2207_06248	7.65e-59	183.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,1S3Q2@1236|Gammaproteobacteria,1J5YN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
k59_21962_1	521393.JH806632_gene1189	3.94e-37	134.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,4D3IY@85005|Actinomycetales	201174|Actinobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_21962_2	471853.Bcav_0883	6.1e-13	67.0	COG0791@1|root,COG0791@2|Bacteria,2GIWB@201174|Actinobacteria	201174|Actinobacteria	M	PFAM NLP P60 protein	spl	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
k59_541444_2	935839.JAGJ01000002_gene745	3.62e-70	224.0	COG0712@1|root,COG0712@2|Bacteria,2GMJ5@201174|Actinobacteria,4F44D@85017|Promicromonosporaceae	201174|Actinobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02109,ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,OSCP
k59_717872_2	305900.GV64_04585	3.24e-40	142.0	COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1XIGP@135619|Oceanospirillales	135619|Oceanospirillales	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_189625_1	1198232.CYCME_1680	9.98e-86	261.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,460S1@72273|Thiotrichales	72273|Thiotrichales	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_1422695_1	471853.Bcav_2500	4.85e-16	79.7	COG0743@1|root,COG0743@2|Bacteria,2GIRV@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2870c	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_1422695_2	548479.HMPREF0573_11343	5.17e-55	181.0	COG3599@1|root,COG3599@2|Bacteria,2GTPA@201174|Actinobacteria,4D5K9@85005|Actinomycetales	201174|Actinobacteria	D	DivIVA domain repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1126642_1	1298863.AUEP01000011_gene593	4.39e-44	161.0	COG2373@1|root,COG2373@2|Bacteria,2H4M3@201174|Actinobacteria	201174|Actinobacteria	I	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,Catalase
k59_659313_2	1357279.N018_08165	2.38e-08	58.2	COG1705@1|root,COG3951@1|root,COG1705@2|Bacteria,COG3951@2|Bacteria,1MX2W@1224|Proteobacteria,1RPGY@1236|Gammaproteobacteria,1Z6K8@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	N	Flagellar rod assembly protein	flgJ	GO:0003674,GO:0005198	-	ko:K02395	-	-	-	-	ko00000,ko02035	-	-	-	Glucosaminidase,Rod-binding
k59_77516_2	1127134.NOCYR_2231	0.000243	43.5	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4FUIM@85025|Nocardiaceae	201174|Actinobacteria	P	E1-E2 ATPase	copB	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686,ko:K21887	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3,3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
k59_131012_1	649831.L083_5746	6.87e-18	88.6	COG0515@1|root,COG1112@1|root,COG0515@2|Bacteria,COG1112@2|Bacteria,2I974@201174|Actinobacteria,4DHUW@85008|Micromonosporales	201174|Actinobacteria	KLT	AAA domain	-	-	-	ko:K14326	ko03013,ko03015,map03013,map03015	M00430	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	AAA_11,AAA_12
k59_1657513_1	1120983.KB894574_gene904	2.23e-94	287.0	COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2TSHG@28211|Alphaproteobacteria,1JN13@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
k59_482683_1	1123401.JHYQ01000026_gene3277	5.86e-129	377.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,4609F@72273|Thiotrichales	72273|Thiotrichales	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_1187738_1	1396858.Q666_02140	2.05e-50	165.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,1S5WH@1236|Gammaproteobacteria,4677Y@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Belongs to the CinA family	ygaD	GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016811,GO:0019159	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
k59_1187738_2	1218352.B597_014290	4.39e-19	86.3	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,1SCZX@1236|Gammaproteobacteria,1Z2MW@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0008452,GO:0008664,GO:0016787,GO:0016788,GO:0016874,GO:0016886,GO:0042578,GO:0140098	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
k59_659321_1	1415778.JQMM01000001_gene302	1.87e-62	211.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1J58Y@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Asparagine synthase	-	-	-	-	-	-	-	-	-	-	-	-	Asn_synthase,GATase_7
k59_717894_1	1286106.MPL1_03508	3.25e-06	48.9	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,462GF@72273|Thiotrichales	72273|Thiotrichales	BQ	histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_1484615_1	1384056.N787_07155	1.37e-15	75.1	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RP6X@1236|Gammaproteobacteria,1X54Y@135614|Xanthomonadales	135614|Xanthomonadales	O	protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_U32
k59_1484615_2	1033802.SSPSH_000259	2.27e-36	135.0	COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,1S6X3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	dnr	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_1484615_3	765913.ThidrDRAFT_1824	9.61e-23	100.0	COG3278@1|root,COG3278@2|Bacteria,1P8T0@1224|Proteobacteria,1T4ST@1236|Gammaproteobacteria,1WW05@135613|Chromatiales	135613|Chromatiales	O	Belongs to the heme-copper respiratory oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1657521_1	595460.RRSWK_00666	1.34e-87	285.0	COG0457@1|root,COG0457@2|Bacteria,2IXP3@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,TPR_16
k59_541472_1	1449347.JQLN01000007_gene1076	1.68e-18	85.9	COG0454@1|root,COG0464@1|root,COG0456@2|Bacteria,COG0464@2|Bacteria,2GJ07@201174|Actinobacteria,2M4MQ@2063|Kitasatospora	201174|Actinobacteria	KO	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,Acetyltransf_1
k59_541472_2	1128421.JAGA01000001_gene2364	8.71e-05	45.4	COG0366@1|root,COG4733@1|root,COG0366@2|Bacteria,COG4733@2|Bacteria,2NP2D@2323|unclassified Bacteria	2|Bacteria	G	Alpha amylase, catalytic domain	apu	-	3.2.1.133,3.2.1.135,3.2.1.54,3.2.1.78	ko:K01208,ko:K01218	ko00051,ko00500,ko01100,ko02024,map00051,map00500,map01100,map02024	-	R01332,R02112,R03122,R11262	RC00467	ko00000,ko00001,ko01000	-	GH13,GH26	-	AMPK1_CBM,Alpha-amylase,Alpha-amylase_N,Big_5,CBM_20,Malt_amylase_C,SLH,fn3
k59_21997_1	1397528.Q671_14065	2.53e-55	180.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1XIDG@135619|Oceanospirillales	135619|Oceanospirillales	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
k59_21997_2	384765.SIAM614_20625	7.7e-06	47.0	COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,2TU5K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Specifically methylates the adenine in position 2030 of 23S rRNA	rlmJ	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008988,GO:0009451,GO:0009987,GO:0010467,GO:0015976,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036307,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.266	ko:K07115	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RsmJ
k59_371106_1	626887.J057_15260	2.36e-31	118.0	COG3637@1|root,COG3637@2|Bacteria,1RHVI@1224|Proteobacteria,1S6UY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	OmpA-like transmembrane domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,OmpA_membrane
k59_371106_2	1395516.PMO01_28185	6.49e-25	102.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	Necessary for normal cell division and for the maintenance of normal septation	engB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
k59_1249615_2	1535422.ND16A_1247	1.1e-57	201.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1597475_1	713586.KB900536_gene365	2.43e-81	261.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1WW9D@135613|Chromatiales	135613|Chromatiales	L	single-stranded-DNA-specific exonuclease RecJ	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_1422716_1	1121935.AQXX01000105_gene326	2.84e-176	506.0	COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,1RP89@1236|Gammaproteobacteria,1XIHH@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
k59_1422716_2	1001585.MDS_4392	4.34e-22	97.1	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,1RP02@1236|Gammaproteobacteria,1YE24@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Aromatic amino acid lyase	hutH	GO:0003674,GO:0003824,GO:0004397,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
k59_1364085_2	497321.C664_19685	1.95e-44	152.0	COG2020@1|root,COG2020@2|Bacteria,1PPQV@1224|Proteobacteria,2VR3S@28216|Betaproteobacteria,2KYVU@206389|Rhodocyclales	206389|Rhodocyclales	O	methyltransferase activity	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	-
k59_542435_1	990073.ATHU01000001_gene487	8.11e-21	93.6	COG0834@1|root,COG0834@2|Bacteria,1MWDK@1224|Proteobacteria,42NVT@68525|delta/epsilon subdivisions,2YN8E@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	ET	Belongs to the bacterial solute-binding protein 3 family	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_256789_1	1237500.ANBA01000029_gene4631	1.29e-17	87.0	COG2267@1|root,COG2267@2|Bacteria,2GQC1@201174|Actinobacteria,4EJMS@85012|Streptosporangiales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
k59_1364089_2	981384.AEYW01000028_gene4249	4.18e-36	132.0	COG1409@1|root,COG1409@2|Bacteria,1NI34@1224|Proteobacteria	1224|Proteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_256795_1	1120983.KB894570_gene1801	2.6e-09	63.2	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2TQSS@28211|Alphaproteobacteria,1JMZ9@119043|Rhodobiaceae	28211|Alphaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADH5_C,Proton_antipo_M,Proton_antipo_N
k59_78932_2	1049564.TevJSym_as00620	1.79e-28	105.0	COG2863@1|root,COG2863@2|Bacteria,1N1DQ@1224|Proteobacteria,1S864@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG2863 Cytochrome c553	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_1423749_1	977880.RALTA_A0757	1.01e-63	214.0	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2VHQJ@28216|Betaproteobacteria,1K0CF@119060|Burkholderiaceae	28216|Betaproteobacteria	C	D-amino acid dehydrogenase	dadA2	-	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2
k59_372521_1	335543.Sfum_2414	2.35e-89	276.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MG3@68525|delta/epsilon subdivisions,2WKC7@28221|Deltaproteobacteria,2MQ7Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	COGs COG0767 ABC-type transport system involved in resistance to organic solvents permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_190652_1	1397528.Q671_10590	1.37e-27	103.0	COG3436@1|root,COG3436@2|Bacteria,1N7AY@1224|Proteobacteria,1SD05@1236|Gammaproteobacteria,1XM3Y@135619|Oceanospirillales	135619|Oceanospirillales	L	IS66 Orf2 like protein	-	-	-	-	-	-	-	-	-	-	-	-	TnpB_IS66
k59_1009909_1	329726.AM1_5447	1.9e-36	138.0	COG0464@1|root,COG0464@2|Bacteria,1G2M7@1117|Cyanobacteria	1117|Cyanobacteria	O	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_307419_1	1121406.JAEX01000007_gene2442	6.15e-24	101.0	COG2890@1|root,COG2890@2|Bacteria,1N5B4@1224|Proteobacteria,42VIS@68525|delta/epsilon subdivisions,2WR53@28221|Deltaproteobacteria,2M92A@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	PFAM methyltransferase small	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_16
k59_660350_1	1165841.SULAR_03382	1.56e-27	105.0	COG1266@1|root,COG1266@2|Bacteria,1ND7U@1224|Proteobacteria	1224|Proteobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_660350_2	765911.Thivi_4072	9.22e-40	137.0	2E2DR@1|root,32XIE@2|Bacteria,1N271@1224|Proteobacteria,1SIHA@1236|Gammaproteobacteria,1X1VU@135613|Chromatiales	135613|Chromatiales	S	SseB protein N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	SseB
k59_78943_1	998088.B565_0140	5.93e-27	102.0	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,1S90Z@1236|Gammaproteobacteria,1Y619@135624|Aeromonadales	135624|Aeromonadales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_78943_2	323848.Nmul_A1204	2.48e-77	243.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2WAY9@28216|Betaproteobacteria,371NX@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
k59_1716010_1	1038860.AXAP01000061_gene2387	2.41e-173	494.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,3JTRC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1364114_1	1288484.APCS01000001_gene582	2.3e-51	185.0	COG0366@1|root,COG3391@1|root,COG0366@2|Bacteria,COG3391@2|Bacteria,1WK9J@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CarboxypepD_reg
k59_1598402_1	1298867.AUES01000038_gene820	8.74e-16	83.2	COG0659@1|root,COG0664@1|root,COG0659@2|Bacteria,COG0664@2|Bacteria,1MVWV@1224|Proteobacteria,2UNZ9@28211|Alphaproteobacteria,3K2C1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	PT	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp,cNMP_binding
k59_660357_1	1279019.ARQK01000056_gene294	5.93e-45	151.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1WXF4@135613|Chromatiales	135613|Chromatiales	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_1485893_1	1134474.O59_002198	1.34e-25	114.0	COG3291@1|root,COG3291@2|Bacteria,1QWZ9@1224|Proteobacteria,1T30T@1236|Gammaproteobacteria,1FGNS@10|Cellvibrio	1236|Gammaproteobacteria	G	Glycosyl hydrolase family 9	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_2,CelD_N,Glyco_hydro_9
k59_1311974_1	1121948.AUAC01000002_gene1417	1.09e-59	199.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2TRHP@28211|Alphaproteobacteria,43WBV@69657|Hyphomonadaceae	28211|Alphaproteobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_23221_1	1218075.BAYA01000009_gene2919	1.75e-39	139.0	COG1877@1|root,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,2VRQ8@28216|Betaproteobacteria,1K3QP@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
k59_23221_2	187272.Mlg_0006	9.49e-43	156.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,1RS4U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Glucoamylase and related glycosyl hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
k59_959801_1	887327.HMPREF0476_1704	5.65e-09	58.5	COG0594@1|root,COG0594@2|Bacteria,1PVTU@1224|Proteobacteria,2VTSA@28216|Betaproteobacteria,2KRCC@206351|Neisseriales	206351|Neisseriales	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
k59_256827_1	58123.JOFJ01000006_gene266	3.61e-79	248.0	COG0638@1|root,COG0638@2|Bacteria,2GMC6@201174|Actinobacteria,4EGN1@85012|Streptosporangiales	201174|Actinobacteria	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
k59_78961_1	96561.Dole_0069	7.47e-05	44.7	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,42TM2@68525|delta/epsilon subdivisions,2WQ0U@28221|Deltaproteobacteria,2MJZ6@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_78961_2	1121405.dsmv_0078	1.08e-67	222.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2MJ2X@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_959802_1	1035308.AQYY01000001_gene3157	3.45e-76	252.0	COG0481@1|root,COG0532@1|root,COG0481@2|Bacteria,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,260ER@186807|Peptococcaceae	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_1188800_1	1379698.RBG1_1C00001G1790	6.29e-29	117.0	COG0191@1|root,COG0191@2|Bacteria,2NPSG@2323|unclassified Bacteria	2|Bacteria	G	Fructose-bisphosphate aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase,OprB,SLH
k59_78969_1	96561.Dole_0237	5.09e-70	238.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,42MYQ@68525|delta/epsilon subdivisions,2WJM2@28221|Deltaproteobacteria,2MIQM@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA polymerase III alpha subunit	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1311995_1	886293.Sinac_3058	2.2e-30	122.0	COG1249@1|root,COG1249@2|Bacteria,2IY39@203682|Planctomycetes	203682|Planctomycetes	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase	sthA	-	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_372575_1	1156935.QWE_15953	4.53e-22	92.4	COG4828@1|root,COG4828@2|Bacteria,1N984@1224|Proteobacteria,2UBT7@28211|Alphaproteobacteria,4BGWZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1622)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1622
k59_1485914_1	748247.AZKH_1082	3.03e-39	145.0	COG2199@1|root,COG3706@2|Bacteria,1R59V@1224|Proteobacteria,2VN7N@28216|Betaproteobacteria,2KUR6@206389|Rhodocyclales	206389|Rhodocyclales	T	COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
k59_1312000_1	1255043.TVNIR_1256	1.74e-54	182.0	COG0430@1|root,COG0430@2|Bacteria,1MX7Q@1224|Proteobacteria,1RSFF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	A	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009975,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
k59_1188807_1	2340.JV46_05470	7.66e-61	198.0	COG0348@1|root,COG0348@2|Bacteria,1MUWD@1224|Proteobacteria,1RZ0Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
k59_718948_1	631362.Thi970DRAFT_02769	7.86e-78	250.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1WW1J@135613|Chromatiales	135613|Chromatiales	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	-	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_1598423_1	471853.Bcav_2116	2.38e-123	379.0	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria	201174|Actinobacteria	G	hydrolase, family 65, central catalytic	-	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
k59_542486_1	2340.JV46_27850	4.19e-27	104.0	COG0517@1|root,COG0517@2|Bacteria,1NJC6@1224|Proteobacteria,1SV2H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_31753_1	883077.HMPREF9241_00001	1.76e-06	46.6	2DEPW@1|root,2ZNS6@2|Bacteria,2GWSK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1604001_1	765913.ThidrDRAFT_2502	2.47e-122	358.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,1WXW8@135613|Chromatiales	135613|Chromatiales	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
k59_265555_1	1120792.JAFV01000001_gene320	2.65e-13	72.8	COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,2TRVM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	phosphatase	-	-	-	ko:K07093	-	-	-	-	ko00000	-	-	-	DUF839
k59_265555_2	1500894.JQNN01000001_gene1285	3.69e-05	47.8	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,2VIWU@28216|Betaproteobacteria,475GJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_4,PAS_8
k59_1664496_1	765910.MARPU_07990	1.6e-178	525.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales	135613|Chromatiales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_967861_1	395493.BegalDRAFT_1677	6.5e-74	243.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,45ZV1@72273|Thiotrichales	72273|Thiotrichales	O	ATP-dependent Clp protease ATP-binding subunit ClpA	-	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1604002_1	384765.SIAM614_18344	3.55e-47	167.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2TRXF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_196312_2	1267534.KB906754_gene2979	1.55e-60	206.0	COG3659@1|root,COG3659@2|Bacteria	2|Bacteria	M	wide pore channel activity	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB
k59_380631_1	497964.CfE428DRAFT_3562	3.38e-42	153.0	COG1459@1|root,COG1459@2|Bacteria,46S5B@74201|Verrucomicrobia	74201|Verrucomicrobia	U	PFAM type II secretion system	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_137749_1	243233.MCA2097	3.76e-28	118.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1XEJP@135618|Methylococcales	135618|Methylococcales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_265559_1	1463901.JOIY01000013_gene6083	2.1e-23	100.0	COG0309@1|root,COG0309@2|Bacteria,2GJ7N@201174|Actinobacteria	201174|Actinobacteria	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
k59_265559_2	1125971.ASJB01000031_gene1301	5.25e-73	231.0	COG0409@1|root,COG0409@2|Bacteria,2GMHA@201174|Actinobacteria,4DYZ6@85010|Pseudonocardiales	201174|Actinobacteria	O	hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
k59_313506_1	443143.GM18_4035	4.99e-30	113.0	2B4XH@1|root,31XQC@2|Bacteria,1RHJF@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_313506_2	1279017.AQYJ01000026_gene57	1.12e-77	259.0	COG1360@1|root,COG2885@1|root,COG1360@2|Bacteria,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,1T4AK@1236|Gammaproteobacteria,46ACU@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,OmpA
k59_31777_1	2002.JOEQ01000021_gene6819	8.9e-16	74.3	COG0824@1|root,COG0824@2|Bacteria,2IFAK@201174|Actinobacteria,4EK5B@85012|Streptosporangiales	201174|Actinobacteria	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
k59_31777_2	1504319.GM45_5705	1.9e-37	137.0	COG0488@1|root,COG0488@2|Bacteria,2GKBQ@201174|Actinobacteria,3UWE5@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	ABC transporter	yjjK	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
k59_380637_1	446469.Sked_09980	8.72e-37	125.0	COG0636@1|root,COG0636@2|Bacteria,2GQI6@201174|Actinobacteria	201174|Actinobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_1084104_1	626887.J057_03215	1.65e-09	62.8	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,464ES@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Belongs to the peptidase S1C family	mucD	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_1258247_1	1713.JOFV01000010_gene1184	1.29e-92	284.0	COG1109@1|root,COG1109@2|Bacteria,2GN87@201174|Actinobacteria,4F0QY@85016|Cellulomonadaceae	201174|Actinobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	GO:0008150,GO:0040007	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1492811_1	471853.Bcav_3056	1.55e-30	120.0	COG0789@1|root,COG0789@2|Bacteria,2I8T8@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding_2,MerR_1
k59_841806_2	177437.HRM2_14820	8.55e-74	228.0	COG4947@1|root,COG4947@2|Bacteria,1PX2K@1224|Proteobacteria,43890@68525|delta/epsilon subdivisions,2XA2S@28221|Deltaproteobacteria,2MPA5@213118|Desulfobacterales	28221|Deltaproteobacteria	S	esterase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_779923_1	870187.Thini_3146	3.73e-54	183.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,4602E@72273|Thiotrichales	72273|Thiotrichales	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
k59_196325_1	525897.Dbac_2486	2e-85	266.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,42PD3@68525|delta/epsilon subdivisions,2WJ58@28221|Deltaproteobacteria,2MATX@213115|Desulfovibrionales	28221|Deltaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05561,ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_1780444_1	1122603.ATVI01000005_gene3860	4.71e-27	114.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9I0@135614|Xanthomonadales	135614|Xanthomonadales	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_31793_1	367299.JOEE01000005_gene3507	4.42e-87	274.0	COG0147@1|root,COG0147@2|Bacteria,2GKJT@201174|Actinobacteria,4FE6P@85021|Intrasporangiaceae	201174|Actinobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_313519_1	100226.SCO0106	3.25e-43	145.0	COG3293@1|root,COG3293@2|Bacteria,2IKID@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DUF4096
k59_1545873_1	243160.BMAA1323	0.000189	47.4	COG2885@1|root,COG2913@1|root,COG2885@2|Bacteria,COG2913@2|Bacteria,1NE4Q@1224|Proteobacteria,2VRQR@28216|Betaproteobacteria,1K7Z2@119060|Burkholderiaceae	28216|Betaproteobacteria	JM	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,SmpA_OmlA
k59_87092_1	713586.KB900536_gene1708	5.65e-63	202.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_87092_2	402626.Rpic_2917	1.11e-180	514.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,1K4Q2@119060|Burkholderiaceae	28216|Betaproteobacteria	NU	twitching motility protein	pilU	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_724433_2	367299.JOEE01000003_gene2676	8.25e-24	96.3	2DM04@1|root,3139Z@2|Bacteria,2IBU0@201174|Actinobacteria,4FGAQ@85021|Intrasporangiaceae	201174|Actinobacteria	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
k59_1848289_1	469610.HMPREF0189_01553	4.29e-05	45.1	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,1KK29@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1848289_2	1249627.D779_3942	2.52e-18	84.7	COG2980@1|root,COG2980@2|Bacteria,1N13K@1224|Proteobacteria	1224|Proteobacteria	M	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane	lptE	-	-	ko:K03643	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptE
k59_31797_2	1304865.JAGF01000001_gene1489	1.12e-06	49.7	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4F0VA@85016|Cellulomonadaceae	201174|Actinobacteria	K	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form	cobB	-	-	-	-	-	-	-	-	-	-	-	SIR2
k59_489436_1	765911.Thivi_1665	8.28e-16	70.9	COG0526@1|root,COG0526@2|Bacteria,1N728@1224|Proteobacteria,1SCEC@1236|Gammaproteobacteria,1WZIE@135613|Chromatiales	135613|Chromatiales	CO	TIGRFAM small redox-active disulfide protein 2	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
k59_489436_2	1123392.AQWL01000008_gene1246	3e-65	206.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,2VQVG@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Methyltransferase type 11	arsM	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
k59_380651_1	1158182.KB905020_gene1680	7.34e-47	156.0	COG3439@1|root,COG3439@2|Bacteria,1RA8I@1224|Proteobacteria,1S34D@1236|Gammaproteobacteria,1WXZJ@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_1780447_1	446466.Cfla_2314	2.39e-94	287.0	COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4F0RS@85016|Cellulomonadaceae	201174|Actinobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_1780447_2	471853.Bcav_1589	4.59e-69	217.0	COG0204@1|root,COG0204@2|Bacteria,2GKVA@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	plsC2	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_1848294_1	391626.OAN307_c03800	2.33e-136	396.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2826 Transposase and inactivated derivatives, IS30 family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_87095_1	1234364.AMSF01000025_gene3546	3.51e-17	81.6	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1X3EH@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	dfp	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k59_87095_2	29486.NJ56_00190	5.13e-80	240.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria,41EZ8@629|Yersinia	1236|Gammaproteobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019103,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0051259,GO:0051260,GO:0055086,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
k59_87095_4	666685.R2APBS1_3849	2.61e-64	202.0	COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria,1X3TD@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
k59_31809_1	2074.JNYD01000003_gene3581	1.23e-40	147.0	COG4638@1|root,COG4638@2|Bacteria,2IDCR@201174|Actinobacteria,4EEXW@85010|Pseudonocardiales	201174|Actinobacteria	P	Rieske [2Fe-2S] domain	-	-	-	ko:K15060	ko00627,ko01120,map00627,map01120	-	R09275	RC00392,RC01533	ko00000,ko00001	-	-	-	Rieske
k59_380659_1	313589.JNB_17558	1.26e-138	400.0	COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria,4FEQQ@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the synthesis of xanthosine monophosphate by the NAD dependent oxidation of inosine monophosphate	guaB3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	IMPDH
k59_779936_1	748247.AZKH_1670	1.46e-89	289.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2VKF8@28216|Betaproteobacteria	28216|Betaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_1014806_1	686340.Metal_0277	6.22e-72	234.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1XE0K@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
k59_1014806_2	270374.MELB17_23685	1.1e-86	271.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,464VA@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048	Formyl_trans_C,Formyl_trans_N
k59_1604035_1	110319.CF8_4032	1.49e-32	121.0	COG2427@1|root,COG2427@2|Bacteria,2IH31@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1641
k59_1721953_1	1713.JOFV01000007_gene2958	1.23e-49	161.0	COG0757@1|root,COG0757@2|Bacteria,2IMBY@201174|Actinobacteria,4F2EM@85016|Cellulomonadaceae	201174|Actinobacteria	E	Dehydroquinase class II	aroQ	GO:0003674,GO:0003824,GO:0003855,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901576	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
k59_1545897_1	367299.JOEE01000001_gene2191	3.02e-17	77.8	COG0098@1|root,COG0098@2|Bacteria,2GJW8@201174|Actinobacteria,4FEE0@85021|Intrasporangiaceae	201174|Actinobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_1545897_2	367299.JOEE01000001_gene2192	7.26e-33	114.0	COG1841@1|root,COG1841@2|Bacteria,2GQV0@201174|Actinobacteria,4FHRR@85021|Intrasporangiaceae	201174|Actinobacteria	J	Ribosomal protein L30	rpmD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
k59_1545897_3	367299.JOEE01000001_gene2193	2.71e-32	116.0	COG0200@1|root,COG0200@2|Bacteria,2II6M@201174|Actinobacteria,4FGFZ@85021|Intrasporangiaceae	201174|Actinobacteria	J	Binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
k59_1133074_1	649831.L083_4048	7.97e-18	82.4	COG4584@1|root,COG4584@2|Bacteria,2GM4J@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_666036_1	96561.Dole_2229	9.56e-97	287.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,42NC0@68525|delta/epsilon subdivisions,2WJK9@28221|Deltaproteobacteria,2MHRY@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_967934_1	1487953.JMKF01000059_gene4863	1.56e-13	74.3	COG2319@1|root,COG3629@1|root,COG2319@2|Bacteria,COG3629@2|Bacteria,1FZVW@1117|Cyanobacteria,1H7R4@1150|Oscillatoriales	1117|Cyanobacteria	K	Wd40 repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,NB-ARC,Pentapeptide,WD40
k59_1664549_1	1121921.KB898706_gene3243	1.57e-17	86.3	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,2PNEG@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	D	TilS substrate C-terminal domain	tilS	GO:0002097,GO:0002101,GO:0002136,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016879,GO:0032267,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
k59_196372_1	1121481.AUAS01000009_gene103	3.98e-19	92.0	COG1835@1|root,COG1835@2|Bacteria,4NIVR@976|Bacteroidetes	976|Bacteroidetes	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_430646_1	471856.Jden_0064	1.36e-81	253.0	COG1105@1|root,COG1105@2|Bacteria,2GK7E@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the carbohydrate kinase PfkB family	fruK	-	2.7.1.11,2.7.1.56	ko:K00882,ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R02071,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
k59_1848353_1	1072685.IX83_06835	3.05e-58	190.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2VJC3@28216|Betaproteobacteria,3T2A1@506|Alcaligenaceae	28216|Betaproteobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
k59_1429659_1	1312959.KI914644_gene1068	5.11e-20	90.5	COG4942@1|root,COG4942@2|Bacteria,2GW48@201174|Actinobacteria	201174|Actinobacteria	D	Protein of unknown function (DUF3375)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3375
k59_313566_1	1134445.AJJM01000010_gene3062	1.11e-31	121.0	COG1090@1|root,COG1090@2|Bacteria,2GJS0@201174|Actinobacteria	201174|Actinobacteria	S	epimerase	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
k59_1664555_1	706587.Desti_1526	3.25e-60	202.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,42MN3@68525|delta/epsilon subdivisions,2WMHC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_1493662_1	243233.MCA3086	2.32e-10	65.9	COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1XEC7@135618|Methylococcales	135618|Methylococcales	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	TPR_1,TPR_2,VWA_2
k59_1665277_1	1249627.D779_2756	3.59e-147	425.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RS8H@1236|Gammaproteobacteria,1WWVZ@135613|Chromatiales	135613|Chromatiales	C	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_1849395_1	269799.Gmet_2043	5.11e-09	65.9	COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,42YJZ@68525|delta/epsilon subdivisions,2WWPU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KM	SdrD B-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SdrD_B,TGFb_propeptide
k59_1084991_1	768706.Desor_2534	1.44e-19	89.0	COG1960@1|root,COG1960@2|Bacteria	2|Bacteria	I	acyl-CoA dehydrogenase activity	acd	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_dehyd_C
k59_1084991_2	177437.HRM2_35680	7.2e-31	117.0	COG1309@1|root,COG1309@2|Bacteria,1MV2V@1224|Proteobacteria,42NW6@68525|delta/epsilon subdivisions,2WPIG@28221|Deltaproteobacteria,2MI81@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Tetracycline transcriptional regulator YsiA domain protein	-	-	-	ko:K13770	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_4,TetR_N
k59_266825_1	710687.KI912270_gene3170	7.18e-32	115.0	COG3651@1|root,COG3651@2|Bacteria,2IHNI@201174|Actinobacteria,2396K@1762|Mycobacteriaceae	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	ko:K09966	-	-	-	-	ko00000	-	-	-	DUF2237
k59_431319_1	713586.KB900536_gene1051	1.75e-164	468.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1WWB3@135613|Chromatiales	135613|Chromatiales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_431324_2	497964.CfE428DRAFT_6435	9.07e-72	222.0	2DMZE@1|root,32UJW@2|Bacteria,46T2C@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1321236_1	1236689.MMALV_12400	2.64e-36	137.0	COG1120@1|root,arCOG00198@2157|Archaea,2XV8E@28890|Euryarchaeota,3F3J4@33867|unclassified Euryarchaeota	28890|Euryarchaeota	P	ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_381717_1	1089553.Tph_c13390	7.72e-65	209.0	COG0327@1|root,COG0327@2|Bacteria,1UK7Y@1239|Firmicutes,248IP@186801|Clostridia,42F63@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_490145_2	313612.L8106_10482	7.26e-30	110.0	COG1942@1|root,COG1942@2|Bacteria,1G6RE@1117|Cyanobacteria,1HBS7@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM macrophage migration inhibitory factor	-	-	-	-	-	-	-	-	-	-	-	-	MIF
k59_969003_1	1304865.JAGF01000001_gene912	3.69e-273	768.0	COG1501@1|root,COG1501@2|Bacteria,2GP4V@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
k59_1195380_1	998674.ATTE01000001_gene293	1.95e-136	415.0	COG0749@1|root,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,45ZUW@72273|Thiotrichales	72273|Thiotrichales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1627368_2	1449068.JMLQ01000003_gene2082	3.98e-26	105.0	COG0861@1|root,COG0861@2|Bacteria,2GIWU@201174|Actinobacteria,4FUZ0@85025|Nocardiaceae	201174|Actinobacteria	P	Integral membrane protein TerC family	terC	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
k59_219809_1	314278.NB231_00525	2.78e-80	255.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1WXYV@135613|Chromatiales	135613|Chromatiales	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	mltF	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
k59_1393279_2	446466.Cfla_1045	9.66e-29	114.0	COG0477@1|root,COG0477@2|Bacteria,2I2Q2@201174|Actinobacteria,4F0N0@85016|Cellulomonadaceae	201174|Actinobacteria	EGP	TIGRFAM drug resistance transporter, Bcr CflA subfamily	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_1153990_1	1443665.JACA01000020_gene4970	9.32e-28	119.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,4NDU8@976|Bacteroidetes,1HXFM@117743|Flavobacteriia,2YH1X@290174|Aquimarina	976|Bacteroidetes	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_513138_2	439235.Dalk_1050	1.09e-14	70.5	2DSJI@1|root,33GEP@2|Bacteria,1N39S@1224|Proteobacteria,42UW5@68525|delta/epsilon subdivisions,2WR68@28221|Deltaproteobacteria,2MKI9@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
k59_454351_1	356851.JOAN01000003_gene1691	9.85e-56	190.0	COG0575@1|root,COG0575@2|Bacteria,2I7ZA@201174|Actinobacteria,4DBJT@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
k59_1153992_1	1123372.AUIT01000001_gene802	1.12e-21	89.4	COG2077@1|root,COG2077@2|Bacteria,2GI9W@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Redoxin	-	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
k59_1153992_2	706587.Desti_4281	2.4e-23	100.0	COG1196@1|root,COG1730@1|root,COG1196@2|Bacteria,COG1730@2|Bacteria,1R095@1224|Proteobacteria,43CRX@68525|delta/epsilon subdivisions,2X7ZH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Seven times multi-haem cytochrome CxxCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Multi-haem_cyto
k59_1393298_1	1122918.KB907252_gene2941	4.82e-62	204.0	COG3239@1|root,COG3239@2|Bacteria,1TP3B@1239|Firmicutes,4H9TS@91061|Bacilli,26RAC@186822|Paenibacillaceae	91061|Bacilli	I	Fatty acid desaturase	des	-	1.14.19.23,1.14.19.45	ko:K10255	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
k59_1519954_1	1454010.JEOE01000006_gene2137	1.11e-05	47.8	2ECXX@1|root,336V1@2|Bacteria,2GTIK@201174|Actinobacteria,4F2Y4@85016|Cellulomonadaceae	201174|Actinobacteria	S	Family of unknown function (DUF5302)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5302
k59_1519954_2	471853.Bcav_2431	1.72e-85	254.0	COG1327@1|root,COG1327@2|Bacteria,2IHU9@201174|Actinobacteria	201174|Actinobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
k59_1627389_1	1322246.BN4_11946	6.43e-68	224.0	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,42M8T@68525|delta/epsilon subdivisions,2WIXE@28221|Deltaproteobacteria,2M8QM@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0470	CPT,CbiA,GATase_3
k59_219828_1	555779.Dthio_PD2250	7.75e-56	189.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,42R8Z@68525|delta/epsilon subdivisions,2WMXX@28221|Deltaproteobacteria,2MAE4@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin,cNMP_binding
k59_219828_2	156889.Mmc1_3232	1.02e-41	151.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Thioredoxin	trxA2	-	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_219830_1	1454004.AW11_03648	1.06e-49	171.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2VHBA@28216|Betaproteobacteria,1KR7P@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function DUF21	-	-	-	-	-	-	-	-	-	-	-	-	CorC_HlyC,DUF21
k59_630536_1	765912.Thimo_1261	6.03e-102	302.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1WZ7F@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM ATP phosphoribosyltransferase, C-terminal domain	-	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
k59_161612_1	1411685.U062_00779	1.22e-19	89.7	COG4067@1|root,COG4067@2|Bacteria,1N0VV@1224|Proteobacteria,1SZUE@1236|Gammaproteobacteria,1J6NY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	Zn_protease
k59_689752_2	935839.JAGJ01000011_gene409	1.69e-28	114.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,2I5Z7@201174|Actinobacteria,4F4YX@85017|Promicromonosporaceae	201174|Actinobacteria	M	Glycosyltransferase like family 2	-	-	2.4.1.289	ko:K16870	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	Glyco_tranf_2_3,Glyco_trans_1_4,Glycos_transf_2
k59_1627404_1	1035308.AQYY01000002_gene784	5.5e-46	164.0	COG3428@1|root,COG3428@2|Bacteria,1TSRJ@1239|Firmicutes,24FG2@186801|Clostridia,266JR@186807|Peptococcaceae	186801|Clostridia	S	Bacterial PH domain	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
k59_630544_1	977880.RALTA_A1457	1.78e-63	199.0	COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,2VRHB@28216|Betaproteobacteria,1K076@119060|Burkholderiaceae	28216|Betaproteobacteria	D	probably involved in intracellular septation	ispZ	-	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
k59_1569289_2	1123487.KB892847_gene714	4.93e-84	264.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria,2KV2N@206389|Rhodocyclales	206389|Rhodocyclales	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM
k59_1393324_1	1380390.JIAT01000011_gene2612	3.16e-54	172.0	COG0099@1|root,COG0099@2|Bacteria,2IHPN@201174|Actinobacteria,4CQ8S@84995|Rubrobacteria	84995|Rubrobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_1393324_2	469383.Cwoe_1365	9.13e-69	210.0	COG0100@1|root,COG0100@2|Bacteria,2IFFC@201174|Actinobacteria,4CPZ7@84995|Rubrobacteria	84995|Rubrobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
k59_1393324_3	526225.Gobs_4480	2.04e-29	110.0	COG0522@1|root,COG0522@2|Bacteria,2GIRX@201174|Actinobacteria,4EREE@85013|Frankiales	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_1154022_1	1038869.AXAN01000037_gene1605	7.12e-65	216.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VNNI@28216|Betaproteobacteria,1K3QF@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_219856_1	519989.ECTPHS_10306	2.25e-18	80.9	COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,1WY1A@135613|Chromatiales	135613|Chromatiales	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
k59_219856_2	2340.JV46_18710	6.89e-50	160.0	COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,1S5WU@1236|Gammaproteobacteria,1J6QE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	ybaB	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:1901363	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
k59_1746178_1	717785.HYPMC_1090	3.59e-128	376.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2TQPA@28211|Alphaproteobacteria,3N65S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_689769_1	1163408.UU9_06184	1.14e-28	106.0	COG3439@1|root,COG3439@2|Bacteria,1RHJQ@1224|Proteobacteria,1S5ZG@1236|Gammaproteobacteria,1XB3Y@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_1629167_1	667014.Thein_0484	1.32e-09	60.5	COG2204@1|root,COG2204@2|Bacteria,2GH79@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1629167_2	391615.ABSJ01000046_gene2112	1.75e-35	131.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1219950_1	1089545.KB913037_gene3395	8.07e-12	65.5	COG4951@1|root,COG4951@2|Bacteria,2I5PR@201174|Actinobacteria	201174|Actinobacteria	L	DNA primase small subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1219950_2	1032480.MLP_05950	1.19e-20	86.7	2E2ZZ@1|root,32Y0I@2|Bacteria,2IIJC@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1219952_1	765911.Thivi_3406	5.32e-45	160.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1WW8D@135613|Chromatiales	135613|Chromatiales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1219952_2	314278.NB231_11459	1.55e-25	105.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1WW8D@135613|Chromatiales	135613|Chromatiales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1629176_1	1121405.dsmv_2939	2.6e-72	228.0	COG2214@1|root,COG2214@2|Bacteria,1NW19@1224|Proteobacteria,43012@68525|delta/epsilon subdivisions,2WVBG@28221|Deltaproteobacteria,2MNIU@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM heat shock protein DnaJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_572912_1	1380347.JNII01000005_gene2965	9.64e-149	426.0	COG2326@1|root,COG2326@2|Bacteria,2GKRN@201174|Actinobacteria,4EU1X@85013|Frankiales	201174|Actinobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
k59_1287848_1	1232437.KL661998_gene4264	1.66e-69	229.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIVD@28221|Deltaproteobacteria,2MHZ9@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	type II secretion system	pulE-3	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_867543_1	243233.MCA0571	7.4e-89	269.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,1XEM4@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_1571060_1	1120948.KB903220_gene92	1.91e-69	228.0	COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,4DXB8@85010|Pseudonocardiales	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1219970_1	1454010.JEOE01000007_gene2066	3.23e-97	287.0	COG0066@1|root,COG0066@2|Bacteria,2GJ8Z@201174|Actinobacteria,4F0NR@85016|Cellulomonadaceae	201174|Actinobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_750319_2	1168065.DOK_17915	1.2e-16	82.8	COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1T3IX@1236|Gammaproteobacteria,1J9KI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_1155397_1	305900.GV64_09435	1.49e-11	63.5	COG0517@1|root,COG0517@2|Bacteria,1N8E9@1224|Proteobacteria,1SC9B@1236|Gammaproteobacteria,1XMRX@135619|Oceanospirillales	135619|Oceanospirillales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_1155397_2	261292.Nit79A3_1180	4.66e-22	87.8	COG1917@1|root,COG1917@2|Bacteria,1MZNT@1224|Proteobacteria,2WGVF@28216|Betaproteobacteria,373HI@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Cupin domain	-	-	-	ko:K11312	-	-	-	-	ko00000	-	-	-	Cupin_2
k59_1571063_1	388399.SSE37_20612	3.7e-69	220.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2TTQ4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
k59_1039611_1	1382359.JIAL01000001_gene534	2.01e-101	303.0	COG0329@1|root,COG0329@2|Bacteria,3Y69C@57723|Acidobacteria,2JKSD@204432|Acidobacteriia	204432|Acidobacteriia	EM	Dihydrodipicolinate synthetase family	-	-	3.5.4.22	ko:K21062	ko00330,map00330	-	R02280	RC00679	ko00000,ko00001,ko01000	-	-	-	DHDPS
k59_514331_1	105425.BBPL01000012_gene1916	6.94e-28	117.0	COG3850@1|root,COG3850@2|Bacteria,2GIWI@201174|Actinobacteria,2NG77@228398|Streptacidiphilus	201174|Actinobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
k59_339546_2	768671.ThimaDRAFT_0364	2.29e-101	310.0	COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,1RNUM@1236|Gammaproteobacteria,1WW3E@135613|Chromatiales	135613|Chromatiales	S	Deoxyribodipyrimidine photo-lyase-related protein	-	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP
k59_800228_1	1279019.ARQK01000059_gene956	3.68e-74	235.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,1WWKR@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases	cca	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
k59_1690236_1	572477.Alvin_1659	8.11e-33	128.0	COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,1RMJC@1236|Gammaproteobacteria,1WWJN@135613|Chromatiales	135613|Chromatiales	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	-	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
k59_1039634_1	1234364.AMSF01000015_gene3229	3.37e-34	126.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1X3EA@135614|Xanthomonadales	135614|Xanthomonadales	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
k59_1039634_2	1348635.BBJY01000008_gene1721	2.23e-52	184.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1XSUS@135623|Vibrionales	135623|Vibrionales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_1522007_1	367299.JOEE01000005_gene3588	5.24e-141	404.0	COG0109@1|root,COG0109@2|Bacteria,2GJMY@201174|Actinobacteria,4FEY1@85021|Intrasporangiaceae	201174|Actinobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_221526_1	519989.ECTPHS_11010	2.12e-197	561.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1WVW6@135613|Chromatiales	135613|Chromatiales	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_221527_1	1035308.AQYY01000001_gene1996	2.65e-112	332.0	COG0448@1|root,COG0448@2|Bacteria,1TNZW@1239|Firmicutes,24943@186801|Clostridia,260G5@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
k59_1522015_1	858619.CVAR_1138	2.14e-26	108.0	COG0791@1|root,COG3599@1|root,COG0791@2|Bacteria,COG3599@2|Bacteria,2GIWB@201174|Actinobacteria,22K9D@1653|Corynebacteriaceae	201174|Actinobacteria	M	Cell wall-associated hydrolases	-	GO:0005575,GO:0005576	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
k59_1522015_2	1178482.BJB45_02655	2.19e-20	89.0	COG0847@1|root,COG0847@2|Bacteria,1P0GY@1224|Proteobacteria,1S6UR@1236|Gammaproteobacteria,1XJU3@135619|Oceanospirillales	135619|Oceanospirillales	L	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_572958_1	1095767.CAHD01000014_gene930	2.01e-71	226.0	COG0839@1|root,COG0839@2|Bacteria,2GKRS@201174|Actinobacteria,4F0SA@85016|Cellulomonadaceae	201174|Actinobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_867595_1	754476.Q7A_2830	2.52e-48	163.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,4610F@72273|Thiotrichales	72273|Thiotrichales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
k59_163382_1	935866.JAER01000013_gene1133	5.07e-68	224.0	COG1651@1|root,COG3004@1|root,COG1651@2|Bacteria,COG3004@2|Bacteria,2GKIK@201174|Actinobacteria,4DNTA@85009|Propionibacteriales	201174|Actinobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiport_1,Thioredoxin_4
k59_1155438_1	1123319.AUBE01000029_gene5201	0.000175	45.4	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX1	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_750379_2	713587.THITH_10380	1.16e-106	308.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,1WW6I@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_1747685_1	981384.AEYW01000001_gene1490	3.98e-61	201.0	COG1234@1|root,COG1234@2|Bacteria,1RIJP@1224|Proteobacteria	1224|Proteobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B,Lactamase_B_4
k59_1220032_1	1121403.AUCV01000003_gene1868	1.56e-59	191.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,42QTS@68525|delta/epsilon subdivisions,2WN02@28221|Deltaproteobacteria,2MJQ6@213118|Desulfobacterales	28221|Deltaproteobacteria	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2496	GATase
k59_1220032_2	97139.C824_05527	3.63e-66	224.0	COG0512@1|root,COG0547@1|root,COG0512@2|Bacteria,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,36ERC@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
k59_1571134_1	1278309.KB907099_gene2913	7.91e-36	139.0	COG2132@1|root,COG2132@2|Bacteria,1PM6Q@1224|Proteobacteria,1RRZJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1629264_1	682795.AciX8_0216	2.16e-78	260.0	COG2989@1|root,COG2989@2|Bacteria,3Y2YW@57723|Acidobacteria,2JIFK@204432|Acidobacteriia	204432|Acidobacteriia	S	ErfK YbiS YcfS YnhG family protein	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_1629266_2	435590.BVU_1124	3.53e-21	95.1	COG4948@1|root,COG4948@2|Bacteria,4PKP3@976|Bacteroidetes,2FMI4@200643|Bacteroidia,4AMKV@815|Bacteroidaceae	976|Bacteroidetes	M	COG NOG06228 non supervised orthologous group	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	GH97_C,GH97_N,Glyco_hydro_97
k59_800264_1	1499967.BAYZ01000118_gene3300	8.3e-70	223.0	COG1454@1|root,COG1454@2|Bacteria,2NQ5W@2323|unclassified Bacteria	2|Bacteria	C	Iron-containing alcohol dehydrogenase	CT0951	-	1.1.1.1,4.3.3.7	ko:K00001,ko:K01714,ko:K13954	ko00010,ko00071,ko00261,ko00300,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,ko01230,map00010,map00071,map00261,map00300,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220,map01230	M00016,M00525,M00526,M00527	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R10147	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	Fe-ADH
k59_632056_2	1068978.AMETH_3536	1.45e-05	50.8	COG1357@1|root,COG1357@2|Bacteria,2GM3W@201174|Actinobacteria,4E1I8@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Pentapeptide repeats (8 copies)	yybG	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
k59_1629271_1	1267005.KB911259_gene4080	5.41e-43	159.0	COG4206@1|root,COG4206@2|Bacteria,1MUZG@1224|Proteobacteria,2TUNP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1220044_1	426114.THI_0150	2.22e-87	278.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJJW@28216|Betaproteobacteria,1KKYF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	von Willebrand factor (vWF) type A domain	cbbO	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
k59_1571143_1	713586.KB900536_gene2892	5.49e-130	374.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,1RNDY@1236|Gammaproteobacteria,1WW3H@135613|Chromatiales	135613|Chromatiales	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
k59_1571143_2	1026882.MAMP_02979	4.41e-49	166.0	COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,1S66F@1236|Gammaproteobacteria,462KA@72273|Thiotrichales	72273|Thiotrichales	S	Clan AA aspartic protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
k59_1571143_3	640081.Dsui_3244	2.94e-46	156.0	COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,2VJEI@28216|Betaproteobacteria,2KWJH@206389|Rhodocyclales	206389|Rhodocyclales	F	Glutamine amidotransferase class-I	-	-	-	-	-	-	-	-	-	-	-	-	GATase
k59_1571145_1	525897.Dbac_0353	1.88e-37	145.0	COG0577@1|root,COG2234@1|root,COG0577@2|Bacteria,COG2234@2|Bacteria,1MVYE@1224|Proteobacteria,42PKN@68525|delta/epsilon subdivisions,2WIWP@28221|Deltaproteobacteria,2M8ZJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,PA,Peptidase_M28
k59_867651_1	52598.EE36_13818	8.03e-125	362.0	COG0715@1|root,COG0715@2|Bacteria,1MVRA@1224|Proteobacteria,2TQPE@28211|Alphaproteobacteria,3ZVRB@60136|Sulfitobacter	28211|Alphaproteobacteria	P	NMT1/THI5 like	-	-	-	ko:K15598	ko02010,map02010	M00442	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.17.3,3.A.1.17.6	-	-	NMT1
k59_691381_1	1454004.AW11_03987	8.61e-39	135.0	2E9HQ@1|root,333QT@2|Bacteria,1N8T3@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1629284_1	981384.AEYW01000022_gene3728	4.67e-90	280.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_529468_2	234267.Acid_2552	4.32e-28	114.0	COG4872@1|root,COG4872@2|Bacteria,3Y8X5@57723|Acidobacteria	57723|Acidobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
k59_236158_1	1185876.BN8_06112	9.52e-33	123.0	COG1446@1|root,COG1446@2|Bacteria,4NF1U@976|Bacteroidetes,47K5N@768503|Cytophagia	976|Bacteroidetes	E	PFAM peptidase T2 asparaginase 2	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
k59_60687_1	1121875.KB907549_gene1715	2.76e-42	155.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1HZQR@117743|Flavobacteriia	976|Bacteroidetes	K	COGs COG5616 integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,TPR_8
k59_470748_1	367299.JOEE01000001_gene1855	7.46e-95	302.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4FERW@85021|Intrasporangiaceae	201174|Actinobacteria	M	Penicillin-binding Protein	pon1	-	-	-	-	-	-	-	-	-	-	-	PASTA,Transgly,Transpeptidase
k59_1703557_1	331869.BAL199_24829	1.32e-103	315.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,2U1B0@28211|Alphaproteobacteria,4BPJI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	nuoL2	-	1.6.5.3	ko:K00341,ko:K05568	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_646956_1	1209072.ALBT01000031_gene1859	1.96e-32	122.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1FG6Q@10|Cellvibrio	1236|Gammaproteobacteria	K	ParB-like nuclease domain	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_646956_2	1027273.GZ77_22020	9.17e-10	59.3	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1XHC3@135619|Oceanospirillales	135619|Oceanospirillales	D	Chromosome partitioning	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_882609_1	1171373.PACID_33920	8.26e-58	202.0	COG0467@1|root,COG1112@1|root,COG0467@2|Bacteria,COG1112@2|Bacteria,2GKJW@201174|Actinobacteria,4DUFE@85009|Propionibacteriales	201174|Actinobacteria	L	Protein of unknown function (DUF4011)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,AAA_30,DUF3320,DUF4011
k59_60692_2	1121912.AUHD01000004_gene2119	1.69e-41	149.0	COG4313@1|root,COG4313@2|Bacteria,4NS24@976|Bacteroidetes,1I03V@117743|Flavobacteriia	976|Bacteroidetes	C	Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
k59_354206_1	1123255.JHYS01000001_gene1923	1.08e-46	165.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2WGFS@28216|Betaproteobacteria,4AA27@80864|Comamonadaceae	28216|Betaproteobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1175284_1	631362.Thi970DRAFT_03339	3.67e-28	120.0	COG0297@1|root,COG0297@2|Bacteria,1P7F2@1224|Proteobacteria,1RZVJ@1236|Gammaproteobacteria,1WX4C@135613|Chromatiales	135613|Chromatiales	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	-	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_236177_1	1454010.JEOE01000019_gene2345	2.11e-92	286.0	COG0056@1|root,COG0056@2|Bacteria,2GJRJ@201174|Actinobacteria,4F1VE@85016|Cellulomonadaceae	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_1116577_1	555079.Toce_1652	2.69e-19	83.6	COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,24GFQ@186801|Clostridia,42G1K@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
k59_1116577_2	1282876.BAOK01000001_gene3624	1.47e-34	127.0	COG1024@1|root,COG1024@2|Bacteria,1R3Q4@1224|Proteobacteria,2U3E5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_529488_1	1124983.PFLCHA0_c48660	5.23e-12	70.9	COG1647@1|root,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,1RXZI@1236|Gammaproteobacteria,1YRUM@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Serine aminopeptidase, S33	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
k59_823066_1	768671.ThimaDRAFT_2765	1.03e-95	284.0	COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,1RRMA@1236|Gammaproteobacteria,1WWEH@135613|Chromatiales	135613|Chromatiales	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_823066_2	768671.ThimaDRAFT_2764	1.03e-62	200.0	COG3931@1|root,COG3931@2|Bacteria,1QI71@1224|Proteobacteria,1S3FR@1236|Gammaproteobacteria,1X02B@135613|Chromatiales	135613|Chromatiales	E	PFAM N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FGase
k59_1703585_1	765914.ThisiDRAFT_1082	1.49e-73	228.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1WX9S@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_646982_2	1123401.JHYQ01000022_gene1131	7.68e-36	127.0	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,460SA@72273|Thiotrichales	72273|Thiotrichales	S	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate	-	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
k59_1527385_1	398767.Glov_3241	1.15e-34	127.0	COG3009@1|root,COG3009@2|Bacteria,1N8BW@1224|Proteobacteria,42UW2@68525|delta/epsilon subdivisions,2WS0C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K09857	-	-	-	-	ko00000	-	-	-	ABC_trans_aux
k59_1595_1	68194.JNXR01000029_gene2279	1.46e-23	96.3	COG1881@1|root,COG1881@2|Bacteria,2IIR9@201174|Actinobacteria	201174|Actinobacteria	S	Phosphatidylethanolamine-binding protein	lppC	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
k59_470780_1	765912.Thimo_1568	5.23e-91	282.0	COG1463@1|root,COG1463@2|Bacteria,1Q6ZU@1224|Proteobacteria,1S6SW@1236|Gammaproteobacteria,1WXQ4@135613|Chromatiales	135613|Chromatiales	Q	MlaD protein	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_470780_2	765912.Thimo_1106	4.09e-51	169.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1X245@135613|Chromatiales	135613|Chromatiales	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_118650_2	90813.JQMT01000001_gene7	6.81e-24	98.2	COG4232@1|root,COG4232@2|Bacteria,1N90P@1224|Proteobacteria,1SFPD@1236|Gammaproteobacteria,462UN@72273|Thiotrichales	72273|Thiotrichales	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_7
k59_882652_1	2340.JV46_15090	6.62e-104	313.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,1J4X6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_4393,iECSF_1327.ECSF_4063,iJN746.PP_4889	Adenylsucc_synt
k59_941359_1	864051.BurJ1DRAFT_3958	1.06e-32	120.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2VH1U@28216|Betaproteobacteria,1KJK8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0016874,GO:0016877,GO:0016878,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_412065_1	631362.Thi970DRAFT_02259	2.15e-47	154.0	COG0790@1|root,COG0790@2|Bacteria,1N293@1224|Proteobacteria,1SBGP@1236|Gammaproteobacteria,1WYX5@135613|Chromatiales	135613|Chromatiales	S	Sel1-like repeats.	-	-	-	-	-	-	-	-	-	-	-	-	Sel1
k59_412065_2	765913.ThidrDRAFT_1286	2.88e-27	107.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,1RMR5@1236|Gammaproteobacteria,1WYK9@135613|Chromatiales	135613|Chromatiales	G	Isocitrate lyase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
k59_1596_1	1110502.TMO_3481	3.63e-76	251.0	COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,2TW58@28211|Alphaproteobacteria,2JPP0@204441|Rhodospirillales	204441|Rhodospirillales	V	transporter, ATP-binding protein	-	-	-	ko:K13926	-	-	-	-	ko00000	-	-	-	ABC2_membrane_3,ABC_tran
k59_1596_2	1182590.BN5_00241	6.35e-54	182.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,1RS3I@1236|Gammaproteobacteria,1YFBW@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	yhiI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_177316_1	1432050.IE4771_CH01153	1.45e-85	263.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2U1C5@28211|Alphaproteobacteria,4BC24@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
k59_823088_1	404589.Anae109_1775	3.84e-38	146.0	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,42ZD0@68525|delta/epsilon subdivisions,2WU4P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	-	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
k59_1762261_1	396588.Tgr7_1990	1.25e-58	206.0	COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales	135613|Chromatiales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,Response_reg
k59_470795_1	1304284.L21TH_0287	3.83e-19	93.6	COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,36DPA@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
k59_1821860_1	1089553.Tph_c01430	7.55e-76	251.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia,42HRB@68295|Thermoanaerobacterales	186801|Clostridia	C	Molydopterin dinucleotide binding domain	-	-	1.7.2.3,1.8.5.3	ko:K07306,ko:K07812	ko00920,map00920	-	R09501	RC02555	ko00000,ko00001,ko01000,ko02000	5.A.3.3,5.A.3.4	-	-	Molybdopterin,Molydop_binding
k59_1234048_1	1217718.ALOU01000007_gene1259	4.78e-65	210.0	COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2VM5U@28216|Betaproteobacteria,1KF02@119060|Burkholderiaceae	28216|Betaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
k59_1234049_1	717785.HYPMC_4093	3.61e-61	213.0	COG3206@1|root,COG3206@2|Bacteria,1QW82@1224|Proteobacteria,2TWS3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	protein involved in exopolysaccharide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1703616_1	98439.AJLL01000081_gene2520	1.83e-63	218.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,1G2E2@1117|Cyanobacteria,1JJJ8@1189|Stigonemataceae	1117|Cyanobacteria	C	Domain of unknown function	nifJ	GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iJN678.nifJ	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_177332_1	981336.F944_00994	3.67e-38	139.0	COG3471@1|root,COG3471@2|Bacteria,1MZA2@1224|Proteobacteria,1S793@1236|Gammaproteobacteria,3NJEW@468|Moraxellaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF541)	Z012_10940	-	-	-	-	-	-	-	-	-	-	-	SIMPL
k59_647818_2	446466.Cfla_1710	4.62e-169	486.0	COG2265@1|root,COG2265@2|Bacteria,2GIR3@201174|Actinobacteria,4F0F6@85016|Cellulomonadaceae	201174|Actinobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_647818_3	1713.JOFV01000016_gene24	2.08e-279	795.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4F1NI@85016|Cellulomonadaceae	201174|Actinobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	ctpE	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	-	ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.23	-	-	E1-E2_ATPase,Hydrolase
k59_1410936_1	933262.AXAM01000036_gene2170	7.77e-101	322.0	COG0613@1|root,COG0613@2|Bacteria,1Q7I9@1224|Proteobacteria,42M1D@68525|delta/epsilon subdivisions,2WIMC@28221|Deltaproteobacteria,2MIFA@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_530431_1	1108045.GORHZ_164_00250	9.89e-94	278.0	COG1290@1|root,COG1290@2|Bacteria,2HG31@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome b(N-terminal)/b6/petB	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_N_2
k59_471675_1	1163617.SCD_n01329	1.12e-75	234.0	COG0489@1|root,COG0489@2|Bacteria,1MVI9@1224|Proteobacteria,2VN0C@28216|Betaproteobacteria	28216|Betaproteobacteria	D	Capsular exopolysaccharide family	epsG	-	2.7.10.1	ko:K08252,ko:K16692	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_31,CbiA,GNVR,Wzz
k59_647825_1	1304865.JAGF01000001_gene2021	1.14e-17	91.3	COG1983@1|root,COG1983@2|Bacteria,2GIVS@201174|Actinobacteria,4F19Z@85016|Cellulomonadaceae	201174|Actinobacteria	KT	PspC domain	pspC	-	-	-	-	-	-	-	-	-	-	-	DUF2154,PspC
k59_1176172_1	1121441.AUCX01000006_gene856	5.05e-24	110.0	COG3829@1|root,COG4191@1|root,COG4564@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,COG4564@2|Bacteria,1RCM9@1224|Proteobacteria,42N6Y@68525|delta/epsilon subdivisions,2WJVA@28221|Deltaproteobacteria,2M8BT@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,NMT1,PAS_3,PAS_4,Response_reg,dCache_1,sCache_2
k59_178174_1	243233.MCA2492	5.23e-39	142.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,1RMB0@1236|Gammaproteobacteria,1XEPM@135618|Methylococcales	135618|Methylococcales	H	PFAM Mur ligase	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_178174_2	1335757.SPICUR_07210	6.42e-134	387.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1WW2U@135613|Chromatiales	135613|Chromatiales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1234926_1	110319.CF8_4008	8.63e-28	114.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_999942_1	384765.SIAM614_13728	2.21e-25	102.0	COG2382@1|root,COG2382@2|Bacteria,1QX0K@1224|Proteobacteria,2TYA9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_1352229_1	1123393.KB891316_gene1129	3.56e-29	108.0	COG0693@1|root,COG0693@2|Bacteria,1N7T2@1224|Proteobacteria,2VS5Q@28216|Betaproteobacteria,1KSPI@119069|Hydrogenophilales	119069|Hydrogenophilales	S	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
k59_1352229_2	1232683.ADIMK_2387	2.18e-31	120.0	COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,1RNKH@1236|Gammaproteobacteria,4678G@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	yibQ	-	-	ko:K09798	-	-	-	-	ko00000	-	-	-	Polysacc_deac_2
k59_1645988_1	84531.JMTZ01000096_gene709	3.56e-100	310.0	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,1RMC2@1236|Gammaproteobacteria,1X3M4@135614|Xanthomonadales	135614|Xanthomonadales	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004721,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009987,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0017076,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
k59_942567_1	1380354.JIAN01000009_gene3850	9.46e-102	305.0	COG0473@1|root,COG0473@2|Bacteria,2GK44@201174|Actinobacteria,4F23E@85016|Cellulomonadaceae	201174|Actinobacteria	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_61994_1	1049564.TevJSym_ad00810	1.11e-42	154.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1J530@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	FP	Belongs to the GppA Ppx family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_471698_1	991905.SL003B_1252	1.15e-13	70.9	COG0480@1|root,COG0480@2|Bacteria,1MU2W@1224|Proteobacteria,2TYVK@28211|Alphaproteobacteria,4BPUJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Elongation factor G, domain IV	MA20_05220	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1469677_1	585.DR95_3644	7.37e-51	182.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,3Z153@583|Proteus	1236|Gammaproteobacteria	C	acyl-CoA dehydrogenase YafH of Escherichia coli K06445	fadE	GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	iSbBS512_1146.SbBS512_E0217	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_1645992_1	281687.CJA02964b	2.94e-14	73.9	COG1100@1|root,KOG2391@1|root,KOG0393@2759|Eukaryota,KOG2391@2759|Eukaryota	2759|Eukaryota	O	Tumor susceptibility	STP22	GO:0000813,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005829,GO:0005886,GO:0006508,GO:0006511,GO:0006605,GO:0006612,GO:0006623,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006862,GO:0006886,GO:0007034,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009898,GO:0009987,GO:0010008,GO:0010605,GO:0012505,GO:0015031,GO:0015711,GO:0015748,GO:0015833,GO:0015865,GO:0015867,GO:0015868,GO:0015893,GO:0015931,GO:0016020,GO:0016192,GO:0019222,GO:0019538,GO:0019941,GO:0030163,GO:0031090,GO:0031323,GO:0031324,GO:0031396,GO:0031397,GO:0031399,GO:0031400,GO:0031410,GO:0031982,GO:0032182,GO:0032268,GO:0032269,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0036452,GO:0042221,GO:0042493,GO:0042886,GO:0043130,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0045184,GO:0045324,GO:0046618,GO:0046907,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051246,GO:0051248,GO:0051503,GO:0051603,GO:0051641,GO:0051649,GO:0060255,GO:0065007,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072594,GO:0072657,GO:0072665,GO:0072666,GO:0080090,GO:0090150,GO:0097708,GO:0098552,GO:0098562,GO:0098588,GO:0098796,GO:0098805,GO:1901264,GO:1901564,GO:1901565,GO:1901575,GO:1902914,GO:1902915,GO:1903320,GO:1903321,GO:1904669	3.1.2.12	ko:K01070,ko:K04392,ko:K07860,ko:K12183	ko00680,ko01120,ko01200,ko04010,ko04013,ko04014,ko04015,ko04024,ko04062,ko04071,ko04144,ko04145,ko04151,ko04310,ko04360,ko04370,ko04380,ko04510,ko04520,ko04530,ko04620,ko04650,ko04662,ko04664,ko04666,ko04670,ko04722,ko04810,ko04932,ko04933,ko04972,ko05014,ko05100,ko05120,ko05131,ko05132,ko05167,ko05200,ko05203,ko05205,ko05210,ko05211,ko05212,ko05231,ko05416,ko05418,map00680,map01120,map01200,map04010,map04013,map04014,map04015,map04024,map04062,map04071,map04144,map04145,map04151,map04310,map04360,map04370,map04380,map04510,map04520,map04530,map04620,map04650,map04662,map04664,map04666,map04670,map04722,map04810,map04932,map04933,map04972,map05014,map05100,map05120,map05131,map05132,map05167,map05200,map05203,map05205,map05210,map05211,map05212,map05231,map05416,map05418	M00409	R00527	RC00167,RC00320	ko00000,ko00001,ko00002,ko01000,ko04031,ko04131,ko04147	-	CE1	-	Ras,UEV,Vps23_core
k59_1117346_1	439235.Dalk_2276	2.34e-113	340.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2WJQS@28221|Deltaproteobacteria,2MI12@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hynA	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.12.2.1,1.12.5.1,1.12.7.2,1.12.99.6	ko:K00437,ko:K00533,ko:K05922,ko:K06281	ko00633,ko01120,map00633,map01120	-	R00019,R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_1528239_2	1163407.UU7_11492	2.24e-49	170.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1X3CZ@135614|Xanthomonadales	135614|Xanthomonadales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_883863_1	377629.TERTU_3437	2.69e-05	45.8	arCOG03638@1|root,2Z7NN@2|Bacteria,1R3Y6@1224|Proteobacteria,1RTWY@1236|Gammaproteobacteria,2PPR1@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1538)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1538
k59_883863_2	1132855.KB913035_gene83	2.01e-29	117.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2VJ75@28216|Betaproteobacteria,2KNIV@206350|Nitrosomonadales	206350|Nitrosomonadales	P	NnrS protein	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
k59_1294780_1	713587.THITH_10360	2.85e-107	321.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1WWH3@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_119567_1	631362.Thi970DRAFT_04553	6.15e-48	158.0	296YQ@1|root,2ZU7A@2|Bacteria,1RDAE@1224|Proteobacteria,1S6SJ@1236|Gammaproteobacteria,1X06C@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_119567_2	631362.Thi970DRAFT_04554	1.33e-23	97.4	COG3005@1|root,COG3005@2|Bacteria,1QZ6I@1224|Proteobacteria,1RXZD@1236|Gammaproteobacteria,1X0FD@135613|Chromatiales	135613|Chromatiales	C	PFAM Class III cytochrome C family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_530474_1	1042377.AFPJ01000037_gene3000	1.96e-28	110.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,1RMK2@1236|Gammaproteobacteria,464DE@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_530474_2	1415778.JQMM01000001_gene1613	6.57e-14	68.9	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,1S41P@1236|Gammaproteobacteria,1J637@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
k59_1469686_1	1121033.AUCF01000006_gene4073	7.91e-81	268.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2TSVH@28211|Alphaproteobacteria,2JPVV@204441|Rhodospirillales	204441|Rhodospirillales	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
k59_1234949_1	1348657.M622_00925	3.81e-79	263.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2VHYQ@28216|Betaproteobacteria,2KUFA@206389|Rhodocyclales	206389|Rhodocyclales	H	methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_1059043_1	305700.B447_00891	5.16e-96	313.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV1U@206389|Rhodocyclales	206389|Rhodocyclales	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_9,Response_reg
k59_1176205_1	765914.ThisiDRAFT_1083	4.68e-14	69.7	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,1WY5S@135613|Chromatiales	135613|Chromatiales	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_1176205_2	1260251.SPISAL_04490	3.04e-109	321.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1WX9S@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_1823054_1	2340.JV46_22530	4.79e-54	182.0	COG0845@1|root,COG0845@2|Bacteria,1PDUT@1224|Proteobacteria,1RQKD@1236|Gammaproteobacteria,1JBNA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_3,HlyD_D23,OEP
k59_706597_1	748658.KB907312_gene1878	4.07e-40	144.0	COG3271@1|root,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,1S2EC@1236|Gammaproteobacteria,1X0UF@135613|Chromatiales	135613|Chromatiales	NU	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2,TPR_16
k59_706597_2	1385515.N791_03520	7.71e-22	89.7	2E445@1|root,32Z0E@2|Bacteria,1N7FY@1224|Proteobacteria,1SDJE@1236|Gammaproteobacteria,1X82S@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1117357_1	591159.ACEZ01000197_gene2841	1.01e-78	255.0	COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria	201174|Actinobacteria	C	malic enzyme	-	-	1.1.1.38,4.1.1.101	ko:K00027,ko:K22212	ko00620,ko01120,ko01200,ko02020,map00620,map01120,map01200,map02020	-	R00214,R11074	RC00105,RC00282	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
k59_355488_1	1469245.JFBG01000080_gene290	3.98e-48	166.0	COG1163@1|root,COG1163@2|Bacteria,1RFPD@1224|Proteobacteria	1224|Proteobacteria	S	TGS domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,TGS
k59_471722_1	933262.AXAM01000023_gene663	3.68e-28	112.0	COG0079@1|root,COG0283@1|root,COG0079@2|Bacteria,COG0283@2|Bacteria,1MW7I@1224|Proteobacteria,42NCH@68525|delta/epsilon subdivisions,2WJDR@28221|Deltaproteobacteria,2MIX3@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_767783_2	1499967.BAYZ01000190_gene3828	3.32e-34	126.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH,DUF2064,HMG-CoA_red
k59_241665_1	321846.PS417_26715	2.99e-30	115.0	COG0791@1|root,COG0791@2|Bacteria,1N0EE@1224|Proteobacteria,1RP3P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0791 Cell wall-associated hydrolases (invasion-associated proteins)	yafL	GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0006022,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009254,GO:0016787,GO:0019538,GO:0030203,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901564	3.2.1.14	ko:K01183,ko:K19303	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000,ko01002,ko01011	-	GH18	-	NLPC_P60
k59_241665_2	1123392.AQWL01000010_gene2296	2.53e-40	145.0	COG1073@1|root,COG1073@2|Bacteria,1N1WH@1224|Proteobacteria,2W50B@28216|Betaproteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3530)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3530
k59_592548_1	1238182.C882_1453	1.51e-63	210.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2TVHI@28211|Alphaproteobacteria,2JR2P@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome D1 heme domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_1473533_1	1108045.GORHZ_118_00660	1.67e-66	218.0	COG0531@1|root,COG0531@2|Bacteria,2IDWU@201174|Actinobacteria,4GEG4@85026|Gordoniaceae	201174|Actinobacteria	E	Amino acid permease	potE	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_241668_1	1380354.JIAN01000005_gene1258	3.61e-86	271.0	COG0668@1|root,COG0668@2|Bacteria,2GJ51@201174|Actinobacteria,4F0HD@85016|Cellulomonadaceae	201174|Actinobacteria	M	Mechanosensitive ion channel	mscS	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_7784_1	998088.B565_1160	3.47e-66	210.0	COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,1S1ZX@1236|Gammaproteobacteria,1Y5FB@135624|Aeromonadales	135624|Aeromonadales	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.20	ko:K06181	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
k59_1414502_1	1123288.SOV_1c09030	8.96e-32	123.0	COG1237@1|root,COG1237@2|Bacteria,1VDQ3@1239|Firmicutes	1239|Firmicutes	S	Beta-lactamase superfamily domain	dhpS	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_299136_2	879212.DespoDRAFT_02934	2.48e-15	77.0	COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,42QBM@68525|delta/epsilon subdivisions,2WNZE@28221|Deltaproteobacteria,2MNJM@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
k59_181553_1	367299.JOEE01000004_gene1124	8.39e-71	229.0	COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria,4FET0@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_1828799_1	1286106.MPL1_00407	1.33e-64	206.0	COG4787@1|root,COG4787@2|Bacteria,1NZWQ@1224|Proteobacteria,1RNVX@1236|Gammaproteobacteria,460DS@72273|Thiotrichales	72273|Thiotrichales	N	TIGRFAM flagellar basal-body rod protein FlgF	-	-	-	ko:K02391	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
k59_534493_1	1265505.ATUG01000002_gene2499	3.65e-78	244.0	arCOG06710@1|root,2ZAS5@2|Bacteria	2|Bacteria	H	Dimethylamine methyltransferase (Dimeth_PyL)	-	-	2.1.1.249	ko:K16178	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09999,R10015	RC00035,RC00556,RC01144,RC02986	ko00000,ko00001,ko00002,ko01000	-	-	-	Dimeth_Pyl
k59_1180057_1	686340.Metal_3479	5.66e-65	211.0	COG2866@1|root,COG2866@2|Bacteria,1N6CX@1224|Proteobacteria,1RZAW@1236|Gammaproteobacteria,1XE1U@135618|Methylococcales	135618|Methylococcales	E	Protein of unknown function (DUF2817)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2817
k59_593119_1	686340.Metal_1013	2.98e-212	598.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,1XDJW@135618|Methylococcales	135618|Methylococcales	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_123467_1	593907.Celgi_2126	3.65e-72	224.0	COG1461@1|root,COG1461@2|Bacteria,2HEQ9@201174|Actinobacteria,4F153@85016|Cellulomonadaceae	201174|Actinobacteria	S	TIGRFAM dihydroxyacetone kinase, L subunit	dhaL	-	2.7.1.121	ko:K05879	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak2
k59_1590556_1	768671.ThimaDRAFT_4609	5.01e-29	115.0	COG0674@1|root,COG0674@2|Bacteria,1QVAZ@1224|Proteobacteria,1S0VA@1236|Gammaproteobacteria,1WVZZ@135613|Chromatiales	135613|Chromatiales	C	pyruvate-flavodoxin oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1590556_2	572477.Alvin_0422	6.76e-67	214.0	COG4322@1|root,COG4322@2|Bacteria,1R4WQ@1224|Proteobacteria,1SZ11@1236|Gammaproteobacteria,1WX5W@135613|Chromatiales	135613|Chromatiales	S	Uncharacterized protein conserved in bacteria (DUF2272)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2272
k59_1474403_1	1385521.N803_02465	1.24e-06	50.4	COG1091@1|root,COG1091@2|Bacteria,2GNY8@201174|Actinobacteria,4FEPF@85021|Intrasporangiaceae	201174|Actinobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rmlD	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
k59_1474403_2	1449069.JMLO01000017_gene3336	1.29e-67	209.0	COG1898@1|root,COG1898@2|Bacteria,2GMW4@201174|Actinobacteria,4FU7V@85025|Nocardiaceae	201174|Actinobacteria	M	dTDP-4-dehydrorhamnose 3,5-epimerase	rmlC	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008830,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3465	dTDP_sugar_isom
k59_1650018_1	1249627.D779_2617	3.76e-64	212.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1WVY6@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
k59_1063300_1	1268635.Loa_01696	1.22e-60	199.0	COG1376@1|root,COG1376@2|Bacteria,1RDPN@1224|Proteobacteria,1S5BH@1236|Gammaproteobacteria,1JDC8@118969|Legionellales	118969|Legionellales	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD_2
k59_1474407_1	446466.Cfla_1785	4.78e-62	197.0	COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,4F1PW@85016|Cellulomonadaceae	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA1	GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.11,2.7.8.5	ko:K00995,ko:K00999	ko00562,ko00564,ko01100,ko04070,map00562,map00564,map01100,map04070	-	R01801,R01802	RC00002,RC00017,RC00078,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_182201_1	1207075.PputUW4_02736	2.21e-06	50.4	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.8	ko:K00128,ko:K00130	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00555	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_182201_2	489825.LYNGBM3L_52770	1e-68	214.0	COG1028@1|root,COG1028@2|Bacteria,1GBR3@1117|Cyanobacteria	1117|Cyanobacteria	IQ	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_361236_1	743718.Isova_0221	1.74e-12	72.8	COG1403@1|root,COG1403@2|Bacteria,2GP2N@201174|Actinobacteria,4F4BM@85017|Promicromonosporaceae	201174|Actinobacteria	V	HNH nucleases	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_768307_1	196162.Noca_2938	1.63e-84	262.0	COG5002@1|root,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4DTJI@85009|Propionibacteriales	201174|Actinobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_475712_1	765911.Thivi_2089	1.43e-48	161.0	COG4674@1|root,COG4674@2|Bacteria,1MUBR@1224|Proteobacteria,1RM8F@1236|Gammaproteobacteria,1WXAW@135613|Chromatiales	135613|Chromatiales	S	pfam abc	-	-	-	ko:K11962	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran,BCA_ABC_TP_C
k59_475712_2	765913.ThidrDRAFT_2217	2.74e-66	211.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,1RMAZ@1236|Gammaproteobacteria,1WX99@135613|Chromatiales	135613|Chromatiales	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K11961	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
k59_827715_1	1049564.TevJSym_aj00080	2.87e-46	157.0	COG3637@1|root,COG3637@2|Bacteria,1RDPZ@1224|Proteobacteria,1S4GQ@1236|Gammaproteobacteria,1JADW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
k59_1532121_2	335543.Sfum_0594	4.69e-16	72.4	2DPG1@1|root,331X6@2|Bacteria,1NCJ5@1224|Proteobacteria,42W03@68525|delta/epsilon subdivisions,2WS3G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
k59_67781_1	566466.NOR53_2438	1.32e-50	175.0	COG3659@1|root,COG3659@2|Bacteria,1R8TI@1224|Proteobacteria,1S21B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Carbohydrate-selective porin OprB	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB
k59_1708337_1	95619.PM1_0204785	3.33e-48	167.0	COG1360@1|root,COG1360@2|Bacteria,1MW1Y@1224|Proteobacteria,1RPQ9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	Flagellar Motor Protein	motB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
k59_1828844_1	187272.Mlg_0956	1.84e-99	315.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WXNN@135613|Chromatiales	135613|Chromatiales	F	PFAM glycosyl transferase family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_1300691_1	72664.XP_006407132.1	1.61e-19	95.9	COG0530@1|root,KOG2399@2759|Eukaryota	2759|Eukaryota	P	calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential	-	GO:0000041,GO:0003674,GO:0005215,GO:0005384,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006828,GO:0006873,GO:0006950,GO:0006970,GO:0008150,GO:0008324,GO:0009628,GO:0009651,GO:0009987,GO:0012505,GO:0012506,GO:0015075,GO:0015077,GO:0015079,GO:0015081,GO:0015318,GO:0015672,GO:0016020,GO:0019725,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030659,GO:0031090,GO:0031410,GO:0031982,GO:0034220,GO:0035725,GO:0042592,GO:0043157,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0046873,GO:0046915,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071421,GO:0071804,GO:0071805,GO:0097708,GO:0098588,GO:0098655,GO:0098660,GO:0098662,GO:0098805	-	ko:K13754	-	-	-	-	ko00000,ko02000	2.A.19.4.4	-	-	Na_Ca_ex
k59_1356168_1	1323663.AROI01000020_gene720	1.26e-25	105.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria	1224|Proteobacteria	NT	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	pilK	-	2.1.1.80	ko:K00575,ko:K02661	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	-	-	-	CheR,CheR_N
k59_1356168_2	1121013.P873_13295	1.43e-07	52.8	COG2198@1|root,COG2198@2|Bacteria,1QY43@1224|Proteobacteria,1S0ZB@1236|Gammaproteobacteria,1X9T8@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	Hpt
k59_1590582_1	247634.GPB2148_769	1.17e-107	325.0	COG0167@1|root,COG0543@1|root,COG0167@2|Bacteria,COG0543@2|Bacteria,1MU7C@1224|Proteobacteria,1T02D@1236|Gammaproteobacteria,1J5J9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the dihydroorotate dehydrogenase family	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,NAD_binding_1
k59_1180089_1	314345.SPV1_06039	3.64e-10	60.1	2E15V@1|root,32WKS@2|Bacteria,1N30I@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1180089_2	2340.JV46_13570	1.51e-26	107.0	2B5QC@1|root,31YJX@2|Bacteria,1RIBA@1224|Proteobacteria,1SPMT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
k59_1766778_1	1074488.AGBX01000001_gene528	3.69e-56	183.0	COG1396@1|root,COG1396@2|Bacteria,2GJS3@201174|Actinobacteria,4FDI2@85020|Dermabacteraceae	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
k59_67792_1	511995.CFPG_382	3.98e-17	83.6	COG0535@1|root,COG0535@2|Bacteria,4PAHJ@976|Bacteroidetes,2FWZQ@200643|Bacteroidia	976|Bacteroidetes	S	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_242870_1	323261.Noc_1604	4.13e-124	392.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales	135613|Chromatiales	E	glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_416808_2	663610.JQKO01000001_gene689	9.17e-41	145.0	COG3128@1|root,COG3128@2|Bacteria,1MUI7@1224|Proteobacteria,2TRH2@28211|Alphaproteobacteria,3NANE@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Prolyl 4-hydroxylase alpha subunit homologues.	piuC	-	-	ko:K07336	-	-	-	-	ko00000,ko01000	-	-	-	2OG-FeII_Oxy_3
k59_1590584_1	1380394.JADL01000008_gene3738	3.11e-07	48.5	2E7PS@1|root,3325B@2|Bacteria,1N7R7@1224|Proteobacteria,2UFCM@28211|Alphaproteobacteria,2JUVZ@204441|Rhodospirillales	204441|Rhodospirillales	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1590584_2	28229.ND2E_1740	2.86e-05	48.9	COG4567@1|root,COG4567@2|Bacteria,1RD7J@1224|Proteobacteria,1S3PE@1236|Gammaproteobacteria,2Q85N@267889|Colwelliaceae	1236|Gammaproteobacteria	KT	Bacterial regulatory protein, Fis family	regA	-	-	ko:K15012	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg
k59_948510_1	1217718.ALOU01000107_gene4231	1.19e-57	201.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1K0FI@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Efflux pump membrane transporter	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_651937_2	1049564.TevJSym_ao00510	1.05e-95	290.0	COG2143@1|root,COG2143@2|Bacteria,1R72D@1224|Proteobacteria,1RSDK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Thioredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
k59_242876_2	243233.MCA1791	6.39e-07	50.8	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,1RYD7@1236|Gammaproteobacteria,1XDNI@135618|Methylococcales	135618|Methylococcales	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	-	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
k59_67799_1	443144.GM21_2039	9.05e-57	187.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42MKP@68525|delta/epsilon subdivisions,2WJU9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_948516_1	469381.Dpep_2374	1.14e-57	191.0	COG3039@1|root,COG3039@2|Bacteria,3TBCF@508458|Synergistetes	508458|Synergistetes	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_123510_1	335543.Sfum_2149	3.26e-63	218.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	2|Bacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388,ko:K16885,ko:K16886	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Fer4,Fer4_20,Fer4_4,Fer4_7,FlpD,NAD_binding_8,Pyr_redox_2
k59_1650054_1	1286106.MPL1_12518	6.72e-81	250.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RQBM@1236|Gammaproteobacteria,4607F@72273|Thiotrichales	72273|Thiotrichales	E	PFAM Aminotransferase class I and II	-	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_710547_1	469383.Cwoe_0601	9.98e-38	145.0	COG2114@1|root,COG2909@1|root,COG3899@1|root,COG2114@2|Bacteria,COG2909@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_16,Guanylate_cyc
k59_889636_1	96561.Dole_1054	6.76e-51	184.0	COG1330@1|root,COG1330@2|Bacteria,1MWTI@1224|Proteobacteria,42N6G@68525|delta/epsilon subdivisions,2WJ4Q@28221|Deltaproteobacteria,2MHPX@213118|Desulfobacterales	28221|Deltaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity	recC	-	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
k59_827748_1	391615.ABSJ01000014_gene1608	9.29e-81	241.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria,1J5P3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
k59_1474468_1	2340.JV46_10830	7.11e-86	259.0	COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,1RMEH@1236|Gammaproteobacteria,1J525@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfE	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
k59_361293_1	187272.Mlg_0845	3.28e-40	135.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,1S5VB@1236|Gammaproteobacteria,1WYVV@135613|Chromatiales	135613|Chromatiales	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
k59_361293_2	1278307.KB907011_gene3668	5.19e-44	144.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,2QIC7@267894|Psychromonadaceae	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
k59_651960_1	456442.Mboo_1450	2.37e-108	319.0	COG0588@1|root,arCOG01993@2157|Archaea,2XWCP@28890|Euryarchaeota,2NB3V@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmA	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
k59_948541_1	1121459.AQXE01000020_gene760	3.88e-25	108.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2M97J@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_9,Response_reg
k59_1590604_1	558173.CDOO_00105	3.03e-13	73.6	COG1172@1|root,COG1172@2|Bacteria,2GM9E@201174|Actinobacteria,22MA6@1653|Corynebacteriaceae	201174|Actinobacteria	G	Ribose xylose arabinose galactoside ABC-type transport systems permease components	iolTB	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_534553_1	1049564.TevJSym_au00340	3.47e-104	310.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1J598@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Oligopeptide transport system permease protein OppB	oppB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_123537_1	1121405.dsmv_1696	3.3e-62	212.0	COG4581@1|root,COG4581@2|Bacteria,1QUPR@1224|Proteobacteria,42NSH@68525|delta/epsilon subdivisions,2WKD7@28221|Deltaproteobacteria,2MHX7@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DEAD DEAH box helicase	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,DSHCT,DUF3516,Helicase_C
k59_1708377_1	469371.Tbis_1453	8.5e-46	156.0	COG2259@1|root,COG2259@2|Bacteria,2IQEY@201174|Actinobacteria,4E4QN@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Methylamine utilisation protein MauE	-	-	-	-	-	-	-	-	-	-	-	-	DoxX,MauE
k59_1415278_1	1123393.KB891329_gene1060	2.76e-11	68.2	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Flg_new,Fn3_assoc,LRR_5,LTD,Peptidase_S9,SpvB,TcdB_toxin_midN,VCBS
k59_889669_2	1304275.C41B8_10138	1.13e-85	277.0	COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria,1T1HJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	nhaP	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger,TrkA_N
k59_827780_1	381666.H16_B2100	5.73e-83	275.0	COG0204@1|root,COG0236@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0236@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,1KG5N@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	amp-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,Acyltransferase,PP-binding
k59_1474524_1	518766.Rmar_0007	3.84e-73	229.0	COG0052@1|root,COG0052@2|Bacteria,4NER0@976|Bacteroidetes,1FJ5G@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_1300789_1	1033730.CAHG01000006_gene1190	1.21e-13	70.1	COG0787@1|root,COG0787@2|Bacteria,2GJJX@201174|Actinobacteria,4DNS3@85009|Propionibacteriales	201174|Actinobacteria	M	Alanine racemase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N
k59_1300789_2	862751.SACTE_3330	5.5e-55	187.0	COG5650@1|root,COG5650@2|Bacteria,2GJYA@201174|Actinobacteria	201174|Actinobacteria	J	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	GT87
k59_1003300_2	1479239.JQMU01000001_gene2368	8.62e-11	64.7	COG0454@1|root,COG0456@2|Bacteria,1QWIU@1224|Proteobacteria,2TWYI@28211|Alphaproteobacteria,2KEG9@204457|Sphingomonadales	204457|Sphingomonadales	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_652000_1	713586.KB900536_gene2226	5.25e-117	364.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
k59_475789_1	2340.JV46_27040	7.9e-07	52.4	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,1JARK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_123572_1	543632.JOJL01000028_gene148	1.52e-37	132.0	COG3226@1|root,COG3226@2|Bacteria,2HUE7@201174|Actinobacteria,4DFXY@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
k59_304537_2	1123400.KB904762_gene2542	7.53e-57	188.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,45ZWB@72273|Thiotrichales	72273|Thiotrichales	G	Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides	nagZ	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
k59_1071271_1	494419.ALPM01000029_gene3100	1.52e-32	121.0	COG1075@1|root,COG1075@2|Bacteria,2IHUU@201174|Actinobacteria,1WBHG@1268|Micrococcaceae	201174|Actinobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_480681_1	768671.ThimaDRAFT_1128	3.24e-112	329.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1WWV1@135613|Chromatiales	135613|Chromatiales	L	PFAM Endonuclease Exonuclease phosphatase	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_128972_1	1304874.JAFY01000007_gene2078	5.5e-19	87.4	COG3039@1|root,COG3039@2|Bacteria,3TBCF@508458|Synergistetes	508458|Synergistetes	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_74880_1	472759.Nhal_1120	4.2e-79	258.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1WXPB@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_252755_1	926569.ANT_03440	1.02e-104	318.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria,2G825@200795|Chloroflexi	200795|Chloroflexi	CO	Cytochrome C biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_252755_2	446471.Xcel_3060	1.08e-07	53.1	2DEZG@1|root,2ZPVV@2|Bacteria,2H0RB@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_252755_3	593907.Celgi_1377	1.33e-50	174.0	COG0491@1|root,COG0491@2|Bacteria,2I9IC@201174|Actinobacteria,4F172@85016|Cellulomonadaceae	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1481865_1	913325.N799_03215	1.5e-55	188.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,1RNG7@1236|Gammaproteobacteria,1X4MB@135614|Xanthomonadales	135614|Xanthomonadales	G	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor	otsA	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
k59_19145_1	28072.Nos7524_2473	2.84e-20	95.9	COG2931@1|root,COG2931@2|Bacteria,1G1I0@1117|Cyanobacteria,1HIHD@1161|Nostocales	1117|Cyanobacteria	Q	Hemolysin-type calcium-binding repeat (2 copies)	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	Cadherin,Calx-beta,DUF4347,HemolysinCabind,Lectin_C
k59_1246793_1	1121472.AQWN01000004_gene807	1.75e-15	75.5	COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,2629K@186807|Peptococcaceae	186801|Clostridia	S	PFAM Amino acid-binding ACT	-	-	-	-	-	-	-	-	-	-	-	-	ACT
k59_1246793_2	1232447.BAHW02000023_gene1474	9.26e-19	86.7	COG2081@1|root,COG2081@2|Bacteria,1TR7U@1239|Firmicutes,2497W@186801|Clostridia,26CKT@186813|unclassified Clostridiales	186801|Clostridia	S	HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
k59_1124968_1	345341.KUTG_00857	1.65e-106	319.0	COG3547@1|root,COG3547@2|Bacteria,2ID3X@201174|Actinobacteria	201174|Actinobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1071286_1	640081.Dsui_0097	3e-45	151.0	COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,2VSDN@28216|Betaproteobacteria,2KWKP@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function, DUF	-	-	-	-	-	-	-	-	-	-	-	-	DUF411
k59_1185794_1	216142.LT40_20610	4.16e-93	305.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,iJN746.PP_1037,ic_1306.c3080	AIRS_C,GATase_5
k59_1836010_2	1122933.JNIY01000004_gene2538	7.74e-70	226.0	COG0472@1|root,COG0472@2|Bacteria,2GIT7@201174|Actinobacteria,4F0NF@85016|Cellulomonadaceae	201174|Actinobacteria	M	PFAM Glycosyl transferase, family 4, conserved region	rfe	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
k59_1771568_1	1150469.RSPPHO_01851	5.27e-96	301.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2TR9U@28211|Alphaproteobacteria,2JPZ9@204441|Rhodospirillales	204441|Rhodospirillales	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_1771568_2	1177928.TH2_16981	1.06e-37	142.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2TSTH@28211|Alphaproteobacteria,2JQ38@204441|Rhodospirillales	204441|Rhodospirillales	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_1713112_2	215803.DB30_5379	4.04e-73	238.0	COG1075@1|root,COG1075@2|Bacteria,1NIPT@1224|Proteobacteria	1224|Proteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1713112_3	1123037.AUDE01000008_gene695	6.49e-32	132.0	COG0574@1|root,COG0574@2|Bacteria,4NH4R@976|Bacteroidetes,1HWKY@117743|Flavobacteriia	976|Bacteroidetes	G	Pyruvate phosphate dikinase	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_715951_1	1517681.HW45_24805	6.21e-22	94.4	COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,1RR95@1236|Gammaproteobacteria,1XVIM@135623|Vibrionales	135623|Vibrionales	C	COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1	fpr	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
k59_1713113_2	380358.XALC_0748	2.17e-36	129.0	COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,1S0KH@1236|Gammaproteobacteria,1X4FI@135614|Xanthomonadales	135614|Xanthomonadales	O	protein-L-isoaspartate O-methyltransferase	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_128993_1	252305.OB2597_09524	1.42e-87	270.0	COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,2TSKB@28211|Alphaproteobacteria,2PC7X@252301|Oceanicola	28211|Alphaproteobacteria	E	Belongs to the Orn Lys Arg decarboxylase class-II family	speF	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_368410_1	1123371.ATXH01000001_gene1300	1e-57	201.0	COG0458@1|root,COG0458@2|Bacteria,2GH37@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	EF	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_955660_2	335543.Sfum_3505	1.58e-49	165.0	29HYV@1|root,304VW@2|Bacteria,1RDPY@1224|Proteobacteria,42RXW@68525|delta/epsilon subdivisions,2WNTT@28221|Deltaproteobacteria,2MS5G@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_421949_1	1123065.ATWL01000002_gene1429	2.67e-115	338.0	COG1186@1|root,COG1186@2|Bacteria,2GJ0F@201174|Actinobacteria	201174|Actinobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_1420773_1	1172188.KB911823_gene675	4.02e-37	139.0	COG4320@1|root,COG4320@2|Bacteria,2GKEK@201174|Actinobacteria,4FG51@85021|Intrasporangiaceae	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
k59_1307811_1	335543.Sfum_2497	4.75e-139	410.0	COG4591@1|root,COG4591@2|Bacteria,1RD9H@1224|Proteobacteria,43AMQ@68525|delta/epsilon subdivisions,2X61T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1246833_1	1382306.JNIM01000001_gene1363	8.38e-47	162.0	COG0112@1|root,COG0112@2|Bacteria,2G624@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	-	-	-	-	-	-	-	-	-	-	-	-	SHMT
k59_539546_1	443144.GM21_2040	1.17e-34	130.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42MAQ@68525|delta/epsilon subdivisions,2WKK0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iAF987.Gmet_1821	BPD_transp_2
k59_1007492_1	1517416.IDAT_11755	2.59e-34	126.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria,2QG43@267893|Idiomarinaceae	1236|Gammaproteobacteria	J	Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle	rsmD	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
k59_1771588_1	1240349.ANGC01000033_gene2984	7.9e-30	121.0	28MY8@1|root,2ZB54@2|Bacteria,2GMYY@201174|Actinobacteria,4FVJJ@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_833165_2	55601.VANGNB10_cI0449	2.44e-19	85.9	COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,1XWKA@135623|Vibrionales	135623|Vibrionales	S	Modulates RecA activity	recX	GO:0006282,GO:0008150,GO:0019219,GO:0019222,GO:0031323,GO:0048583,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0080090,GO:0080134,GO:0080135,GO:2001020	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
k59_1713126_1	930166.CD58_06620	1.98e-27	107.0	COG3133@1|root,COG3133@2|Bacteria,1RJXC@1224|Proteobacteria,1SYAG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	membrane	IV02_08655	-	-	ko:K06077	-	-	-	-	ko00000	-	-	-	Rick_17kDa_Anti
k59_1713126_2	396588.Tgr7_3061	2.55e-59	194.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1WX3U@135613|Chromatiales	135613|Chromatiales	C	PFAM Alcohol dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_896682_1	1713.JOFV01000012_gene733	3.14e-196	560.0	COG0601@1|root,COG0601@2|Bacteria,2GJ2C@201174|Actinobacteria,4F1QD@85016|Cellulomonadaceae	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	oppB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_253834_1	1042876.PPS_3422	3.32e-14	71.6	COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,1RPG4@1236|Gammaproteobacteria,1YWIP@136845|Pseudomonas putida group	1236|Gammaproteobacteria	C	PFAM Isocitrate dehydrogenase NADP-dependent monomeric type	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	IDH
k59_253834_2	1122134.KB893650_gene1076	1.45e-31	113.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria,1XKZ1@135619|Oceanospirillales	135619|Oceanospirillales	S	RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_253834_3	1123487.KB892835_gene3530	9.45e-31	109.0	COG4628@1|root,COG4628@2|Bacteria,1N7DG@1224|Proteobacteria,2VW2Y@28216|Betaproteobacteria,2KXDU@206389|Rhodocyclales	206389|Rhodocyclales	S	Pfam:DUF2132	-	-	-	-	-	-	-	-	-	-	-	-	VF530
k59_540208_1	1283300.ATXB01000001_gene2016	3.35e-74	232.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1XDKV@135618|Methylococcales	135618|Methylococcales	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
k59_1008003_1	6669.EFX73622	5.17e-08	59.7	KOG0266@1|root,KOG0266@2759|Eukaryota,38D6R@33154|Opisthokonta,3BGA2@33208|Metazoa,3CUY8@33213|Bilateria,421ER@6656|Arthropoda	33208|Metazoa	S	WD domain, G-beta repeat	WSB1	GO:0000209,GO:0003674,GO:0003824,GO:0004842,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016567,GO:0016740,GO:0019538,GO:0019787,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070647,GO:0071704,GO:0140096,GO:1901564	-	ko:K10341,ko:K10342	-	-	-	-	ko00000,ko04121	-	-	-	SOCS_box,WD40
k59_188337_1	590998.Celf_3212	2.65e-68	220.0	COG1819@1|root,COG1819@2|Bacteria	2|Bacteria	CG	transferase activity, transferring hexosyl groups	alg2	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,UDPGT
k59_1482788_1	65497.JODV01000003_gene4519	2.14e-56	188.0	COG2038@1|root,COG2038@2|Bacteria,2GJ16@201174|Actinobacteria,4DX78@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	-	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2207	CobU,DBI_PRT
k59_1656197_1	1458427.BAWN01000030_gene1716	5.15e-60	209.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,4A9NT@80864|Comamonadaceae	28216|Betaproteobacteria	C	FAD linked oxidase domain protein	glpCD	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_422609_1	1384054.N790_02800	7.88e-86	263.0	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,1X4SS@135614|Xanthomonadales	135614|Xanthomonadales	C	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
k59_897555_1	1713.JOFV01000007_gene2970	7.28e-105	329.0	COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,4F10T@85016|Cellulomonadaceae	201174|Actinobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_598506_1	990073.ATHU01000001_gene201	7.14e-09	56.6	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,42MFC@68525|delta/epsilon subdivisions,2YMN5@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iIT341.HP0976	AAA_26,Aminotran_3
k59_598506_2	1249627.D779_0646	1.7e-63	205.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,1WXDF@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
k59_1186441_1	1121920.AUAU01000007_gene506	9.45e-107	328.0	COG0477@1|root,COG2814@2|Bacteria,3Y6YQ@57723|Acidobacteria	57723|Acidobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1308719_1	880072.Desac_0919	8.94e-61	197.0	COG1142@1|root,COG1143@1|root,COG1142@2|Bacteria,COG1143@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	psaC	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0009579,GO:0016020,GO:0034357,GO:0042651,GO:0044424,GO:0044436,GO:0044464,GO:0071944	-	ko:K00205,ko:K02573,ko:K02691	ko00195,ko00680,ko01100,ko01120,ko01200,map00195,map00680,map01100,map01120,map01200	M00163,M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko00194	-	-	iJN678.psaC	Fer4,Fer4_20,Fer4_7,GXGXG,Pyr_redox_2
k59_253853_1	1043493.BBLU01000015_gene1115	7.5e-58	193.0	COG0479@1|root,COG0479@2|Bacteria,2I37A@201174|Actinobacteria	201174|Actinobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
k59_1072397_1	1292020.H483_0115355	1.46e-28	108.0	COG1989@1|root,COG1989@2|Bacteria,2GJ7K@201174|Actinobacteria	201174|Actinobacteria	NOU	Peptidase A24A, prepilin type IV	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	Peptidase_A24
k59_1072397_2	590998.Celf_1910	7.23e-43	142.0	COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
k59_75812_2	631362.Thi970DRAFT_03275	1.23e-80	252.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1WWS2@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_598513_1	1089455.MOPEL_029_01380	7.01e-05	44.3	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,4F6BB@85018|Dermatophilaceae	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_598513_2	471856.Jden_1474	4.07e-30	110.0	2E6TR@1|root,331DK@2|Bacteria,2IQF8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_598513_3	1123251.ATWM01000004_gene1956	2.28e-14	72.8	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4FEMJ@85021|Intrasporangiaceae	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_369336_1	742159.HMPREF0004_4476	5.83e-47	170.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VHS7@28216|Betaproteobacteria,3T1M1@506|Alcaligenaceae	28216|Betaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase	fadN	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_540233_1	443598.AUFA01000020_gene3201	9.34e-61	206.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2TR5H@28211|Alphaproteobacteria,3JQXK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_1772234_1	266940.Krad_4341	2.14e-24	107.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria	201174|Actinobacteria	M	penicillin-binding protein	pbp5	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
k59_188367_1	1095769.CAHF01000001_gene3463	1.58e-106	323.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2VJZN@28216|Betaproteobacteria,4735T@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
k59_129672_1	367299.JOEE01000004_gene1374	9.68e-106	335.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4FE3D@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA-directed DNA polymerase	dnaE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_129672_2	367299.JOEE01000004_gene1373	7.6e-44	150.0	COG0564@1|root,COG0564@2|Bacteria,2GIY1@201174|Actinobacteria,4FFFW@85021|Intrasporangiaceae	201174|Actinobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_1713754_1	367299.JOEE01000011_gene3189	1.35e-126	378.0	COG1217@1|root,COG1217@2|Bacteria,2GJUJ@201174|Actinobacteria,4FEJF@85021|Intrasporangiaceae	201174|Actinobacteria	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_75827_1	648757.Rvan_0592	1e-128	386.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria,3N9EG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,Pyr_redox_2
k59_253881_1	756272.Plabr_1918	4.87e-83	254.0	COG0040@1|root,COG0040@2|Bacteria,2IXEV@203682|Planctomycetes	203682|Planctomycetes	F	ATP phosphoribosyltransferase	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
k59_305208_1	888050.HMPREF9004_1177	3.07e-19	92.0	COG2304@1|root,COG2755@1|root,COG2304@2|Bacteria,COG2755@2|Bacteria,2HM3R@201174|Actinobacteria,4D6AV@85005|Actinomycetales	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2,VWA_2
k59_129674_1	1122599.AUGR01000004_gene2068	4.48e-37	131.0	COG1495@1|root,COG1495@2|Bacteria,1PSD8@1224|Proteobacteria,1TAIR@1236|Gammaproteobacteria,1XKDA@135619|Oceanospirillales	135619|Oceanospirillales	O	Disulfide bond formation protein DsbB	-	-	-	-	-	-	-	-	-	-	-	-	DsbB
k59_1361791_1	1121904.ARBP01000003_gene6591	3.28e-24	109.0	COG0531@1|root,COG0531@2|Bacteria,4NDU2@976|Bacteroidetes,47JF7@768503|Cytophagia	976|Bacteroidetes	E	PFAM amino acid permease-associated region	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,AA_permease_2,AA_permease_C,PTS_EIIA_2,TrkA_C,Usp
k59_897588_1	713586.KB900536_gene1938	2.26e-68	232.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,NB-ARC,cNMP_binding
k59_1072436_1	1353531.AZNX01000005_gene3330	2.1e-29	121.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4BJ34@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Tetratricopeptide repeat	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,TPR_2,TPR_8
k59_369354_1	483219.LILAB_27285	2.88e-36	135.0	COG1914@1|root,COG1914@2|Bacteria	2|Bacteria	P	metal ion transmembrane transporter activity	mntH	-	-	-	-	-	-	-	-	-	-	-	Nramp
k59_1072439_1	283942.IL0397	7.58e-79	241.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,2QF6Y@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	ABC transporter	lptB	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
k59_75831_1	265072.Mfla_2071	7.8e-69	231.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,2VJ4Z@28216|Betaproteobacteria,2KM8F@206350|Nitrosomonadales	206350|Nitrosomonadales	P	TrkA-N domain	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_N
k59_305214_1	706587.Desti_2048	1.64e-13	69.7	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,42MB8@68525|delta/epsilon subdivisions,2WIW7@28221|Deltaproteobacteria,2MR08@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Cytochrome bd terminal oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_305214_2	706587.Desti_2047	2.88e-57	187.0	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,42NHN@68525|delta/epsilon subdivisions,2WJ4S@28221|Deltaproteobacteria,2MQ45@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM cytochrome d oxidase, subunit II (cydB)	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
k59_1656231_1	204669.Acid345_2436	1.72e-96	294.0	28IJB@1|root,2Z8K8@2|Bacteria,3Y62T@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1656231_2	223926.28809511	2.29e-26	107.0	COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,1RP2M@1236|Gammaproteobacteria,1XW26@135623|Vibrionales	135623|Vibrionales	S	Mo-co oxidoreductase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
k59_369358_2	236097.ADG881_901	1.95e-19	86.3	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria,1XIV0@135619|Oceanospirillales	135619|Oceanospirillales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_20327_2	177437.HRM2_18740	8.46e-62	194.0	COG0252@1|root,COG0252@2|Bacteria,1RHAW@1224|Proteobacteria,42SNH@68525|delta/epsilon subdivisions,2WPQC@28221|Deltaproteobacteria,2MK6U@213118|Desulfobacterales	28221|Deltaproteobacteria	EJ	Asparaginase, N-terminal	aspG	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
k59_1421447_1	269799.Gmet_1591	4.3e-81	260.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,43TFC@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_1080675_1	1194972.MVAC_26849	2.16e-54	182.0	COG1305@1|root,COG1305@2|Bacteria,2HDEK@201174|Actinobacteria,2334E@1762|Mycobacteriaceae	201174|Actinobacteria	E	transglutaminase-like	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_427922_1	935863.AWZR01000007_gene363	3.75e-129	383.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,1RPN7@1236|Gammaproteobacteria,1X4BQ@135614|Xanthomonadales	135614|Xanthomonadales	E	peptidase M20	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_721973_1	331678.Cphamn1_1607	3.89e-33	120.0	COG0838@1|root,COG0838@2|Bacteria,1FDY8@1090|Chlorobi	1090|Chlorobi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_721973_2	644966.Tmar_0753	2.9e-18	84.0	COG0377@1|root,COG0377@2|Bacteria,1TZS1@1239|Firmicutes,24GH5@186801|Clostridia,3WDHK@538999|Clostridiales incertae sedis	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_261222_1	349163.Acry_1121	8.43e-46	168.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,2JQS7@204441|Rhodospirillales	204441|Rhodospirillales	P	COG0474 Cation transport ATPase	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_427929_1	335543.Sfum_2498	5.93e-60	197.0	COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,42PIT@68525|delta/epsilon subdivisions,2WKT1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	COG4591 ABC-type transport system, involved in lipoprotein release, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1316377_1	1121405.dsmv_0979	4.28e-168	485.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WIQG@28221|Deltaproteobacteria,2MJ8G@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_545293_1	378753.KRH_00450	1.32e-19	93.2	COG0029@1|root,COG0029@2|Bacteria,2I2IJ@201174|Actinobacteria,1W8C1@1268|Micrococcaceae	201174|Actinobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	GO:0008150,GO:0040007	1.4.3.16,2.4.2.19	ko:K00278,ko:K00767	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481,R03348	RC00006,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1595	FAD_binding_2,Succ_DH_flav_C
k59_1130259_1	1121440.AUMA01000011_gene2433	6.45e-43	152.0	COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,42NI3@68525|delta/epsilon subdivisions,2WJ6P@28221|Deltaproteobacteria,2M856@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_1254763_1	240016.ABIZ01000001_gene2737	5.67e-48	159.0	COG4276@1|root,COG4276@2|Bacteria,46W6H@74201|Verrucomicrobia,2IUR6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Pfam Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_193733_1	1033802.SSPSH_003548	2.47e-77	259.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Glutamate synthase	gltB	GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iBWG_1329.BWG_2914,iECDH10B_1368.ECDH10B_3387,iECDH1ME8569_1439.EcDH1_0495,iEcDH1_1363.EcDH1_0495,iPC815.YPO3557	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1316400_1	323848.Nmul_A0474	6.65e-105	320.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,372AD@32003|Nitrosomonadales	28216|Betaproteobacteria	H	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	ilvI	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_777518_1	344747.PM8797T_10469	2.86e-123	364.0	COG1234@1|root,COG1234@2|Bacteria,2J27A@203682|Planctomycetes	203682|Planctomycetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1426888_2	1380390.JIAT01000009_gene2091	1.18e-27	112.0	COG0477@1|root,COG2814@2|Bacteria,2I2EY@201174|Actinobacteria,4CSB4@84995|Rubrobacteria	84995|Rubrobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_1489595_1	859657.RPSI07_mp0044	9.42e-23	93.2	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	ko:K03830	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_10
k59_1489595_2	161528.ED21_27373	2.05e-05	46.2	COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,2TQN7@28211|Alphaproteobacteria,2K2F1@204457|Sphingomonadales	204457|Sphingomonadales	O	OsmC-like protein	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Hydrolase_4,OsmC
k59_427956_1	1165841.SULAR_08035	2.04e-65	199.0	COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,42SE4@68525|delta/epsilon subdivisions,2YPG9@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
k59_427956_2	1165841.SULAR_08030	5.34e-21	87.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,42NV2@68525|delta/epsilon subdivisions,2YMFG@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	ribosomal protein L3	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_1316413_1	1397527.Q670_05870	1.72e-73	234.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1TJAF@1236|Gammaproteobacteria,1XP37@135619|Oceanospirillales	135619|Oceanospirillales	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1367314_1	1123073.KB899241_gene2836	1.77e-38	149.0	COG4188@1|root,COG4188@2|Bacteria,1QUVG@1224|Proteobacteria,1T22C@1236|Gammaproteobacteria,1X4WW@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial virulence factor lipase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_bact_N
k59_1254803_1	518766.Rmar_2551	9.2e-24	98.2	COG0714@1|root,COG0714@2|Bacteria,4NDVZ@976|Bacteroidetes,1FITR@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	ATPase family associated with various cellular activities (AAA)	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1254803_2	118163.Ple7327_0363	4.84e-24	95.9	2CCSR@1|root,32RWC@2|Bacteria,1GEQ5@1117|Cyanobacteria,3VKJG@52604|Pleurocapsales	1117|Cyanobacteria	S	PFAM S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
k59_722009_2	1123070.KB899258_gene1882	3.26e-11	65.5	COG1524@1|root,COG1524@2|Bacteria,46XAN@74201|Verrucomicrobia,2IV7D@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
k59_1191920_1	589865.DaAHT2_0128	6.09e-159	459.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2WJE2@28221|Deltaproteobacteria,2MISS@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_1254819_1	1502851.FG93_00239	1.8e-47	164.0	COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2TUPG@28211|Alphaproteobacteria,3JS7M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1316434_1	269796.Rru_A2073	3.6e-15	74.7	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,2TSQM@28211|Alphaproteobacteria,2JP8M@204441|Rhodospirillales	204441|Rhodospirillales	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
k59_1316434_2	935261.JAGL01000009_gene1208	2.93e-26	108.0	COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,2TU4M@28211|Alphaproteobacteria,43IV9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1426909_2	186497.PF1397	4.92e-70	226.0	COG1180@1|root,arCOG00946@2157|Archaea,2XUB7@28890|Euryarchaeota,242R9@183968|Thermococci	183968|Thermococci	O	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_1316437_1	471853.Bcav_1310	2.33e-90	270.0	COG1637@1|root,COG1637@2|Bacteria,2GIYB@201174|Actinobacteria	201174|Actinobacteria	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	-	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
k59_193774_1	1392489.JPOL01000002_gene577	1.09e-25	104.0	COG1514@1|root,COG1514@2|Bacteria,4NPIG@976|Bacteroidetes,1I1AP@117743|Flavobacteriia	976|Bacteroidetes	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2,AKAP7_NLS
k59_193774_2	261292.Nit79A3_0354	1.22e-09	55.5	COG2154@1|root,COG2154@2|Bacteria,1MZ5Q@1224|Proteobacteria,2VVZF@28216|Betaproteobacteria,373A7@32003|Nitrosomonadales	28216|Betaproteobacteria	H	diol metabolic process	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
k59_1080773_1	472759.Nhal_0245	7.79e-127	368.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,1RP9W@1236|Gammaproteobacteria,1X2E9@135613|Chromatiales	135613|Chromatiales	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
k59_486764_1	1122622.ATWJ01000010_gene1299	2.98e-33	131.0	COG3349@1|root,COG3349@2|Bacteria,2I7PZ@201174|Actinobacteria	201174|Actinobacteria	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
k59_964284_1	1547445.LO80_02570	8.46e-43	150.0	COG1446@1|root,COG1446@2|Bacteria,1MWFC@1224|Proteobacteria,1RNUR@1236|Gammaproteobacteria,460MI@72273|Thiotrichales	72273|Thiotrichales	E	Asparaginase	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase_2
k59_1080780_1	1123261.AXDW01000007_gene2174	9.95e-36	140.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1X4ZI@135614|Xanthomonadales	135614|Xanthomonadales	U	AAA domain	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
k59_1254842_1	443144.GM21_3855	2.45e-31	118.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,42SV9@68525|delta/epsilon subdivisions,2WPXX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Phosphoribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
k59_1719223_1	471853.Bcav_1889	8.78e-261	729.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome b	qcrB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03891	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_N_2
k59_1719223_2	714083.JH370377_gene2250	1.3e-15	74.7	COG0723@1|root,COG0723@2|Bacteria,2GIX6@201174|Actinobacteria,4FKHS@85023|Microbacteriaceae	201174|Actinobacteria	C	Rieske [2Fe-2S] domain	qcrA	-	-	ko:K03890	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Rieske
k59_83461_1	713586.KB900536_gene1376	8.07e-12	65.1	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1WWBT@135613|Chromatiales	135613|Chromatiales	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_83461_2	309807.SRU_0561	3.62e-06	56.2	COG0773@1|root,COG0773@2|Bacteria,4NE1V@976|Bacteroidetes,1FJ2E@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Mur ligase family, catalytic domain	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_964293_1	156889.Mmc1_1369	8.13e-85	258.0	COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	2.7.7.49	ko:K00986,ko:K07497	-	-	-	-	ko00000,ko01000	-	-	-	HTH_32,rve,rve_3
k59_83467_2	497964.CfE428DRAFT_2729	4.75e-31	118.0	COG1209@1|root,COG1209@2|Bacteria,46T9Q@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Nucleotidyl transferase	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_1254845_2	1198232.CYCME_0655	1.33e-94	286.0	arCOG03638@1|root,2Z8W3@2|Bacteria,1N2PH@1224|Proteobacteria,1RMI8@1236|Gammaproteobacteria,461N8@72273|Thiotrichales	72273|Thiotrichales	S	Protein of unknown function (DUF1538)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1538
k59_1254845_3	981085.XP_010107223.1	2.56e-09	58.2	COG1741@1|root,2QQ5A@2759|Eukaryota,37REZ@33090|Viridiplantae,3G8XY@35493|Streptophyta,4JI8S@91835|fabids	35493|Streptophyta	S	Belongs to the pirin family	-	GO:0001101,GO:0003674,GO:0004857,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006952,GO:0007154,GO:0007165,GO:0008150,GO:0009314,GO:0009416,GO:0009605,GO:0009607,GO:0009617,GO:0009628,GO:0009637,GO:0009719,GO:0009725,GO:0009737,GO:0009738,GO:0009755,GO:0009785,GO:0009892,GO:0009987,GO:0010033,GO:0010466,GO:0010605,GO:0016020,GO:0019222,GO:0023052,GO:0030162,GO:0030234,GO:0030414,GO:0030522,GO:0031323,GO:0031324,GO:0032268,GO:0032269,GO:0032870,GO:0033993,GO:0042221,GO:0042742,GO:0043086,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045861,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0051704,GO:0051707,GO:0051716,GO:0052547,GO:0060255,GO:0061134,GO:0065007,GO:0065009,GO:0070887,GO:0071214,GO:0071215,GO:0071229,GO:0071310,GO:0071396,GO:0071478,GO:0071482,GO:0071483,GO:0071495,GO:0071944,GO:0080090,GO:0097305,GO:0097306,GO:0098542,GO:0098772,GO:0104004,GO:1901700,GO:1901701	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
k59_1777740_1	1077974.GOEFS_076_00020	8.85e-15	73.2	COG1122@1|root,COG1122@2|Bacteria,2I9PF@201174|Actinobacteria,4GGYB@85026|Gordoniaceae	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K16784	ko02010,map02010	M00581	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25.1	-	-	ABC_tran
k59_1777740_2	1349820.M707_00350	6.14e-29	114.0	COG0619@1|root,COG0619@2|Bacteria,2IQMQ@201174|Actinobacteria,1WA23@1268|Micrococcaceae	201174|Actinobacteria	P	Cobalt transport protein	-	-	-	ko:K16783	ko02010,map02010	M00581	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25.1	-	-	CbiQ
k59_1316474_1	338963.Pcar_1876	1.82e-31	123.0	COG0637@1|root,COG0637@2|Bacteria,1QW0J@1224|Proteobacteria,43BQD@68525|delta/epsilon subdivisions,2X71F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_964302_2	633697.EubceDRAFT1_1150	1.07e-19	88.2	COG0681@1|root,COG0681@2|Bacteria,1UKFY@1239|Firmicutes,25FW3@186801|Clostridia,25ZUX@186806|Eubacteriaceae	186801|Clostridia	U	Belongs to the peptidase S26 family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_486786_1	2002.JOEQ01000002_gene4505	1.87e-101	301.0	COG1173@1|root,COG1173@2|Bacteria,2GMJC@201174|Actinobacteria,4EH4N@85012|Streptosporangiales	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_261370_1	1123392.AQWL01000006_gene718	4.88e-46	165.0	COG3746@1|root,COG3746@2|Bacteria,1MY3M@1224|Proteobacteria,2VIIP@28216|Betaproteobacteria,1KSJ3@119069|Hydrogenophilales	119069|Hydrogenophilales	P	phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_486788_1	1320556.AVBP01000022_gene2007	2.81e-12	71.6	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2U1EJ@28211|Alphaproteobacteria,43JYN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	U	AAA domain	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22
k59_1489670_1	883.DvMF_0763	7.89e-58	194.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NMZ@68525|delta/epsilon subdivisions,2WIZ0@28221|Deltaproteobacteria,2M7UF@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
k59_964314_1	670307.HYPDE_23913	1.4e-67	225.0	COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,2TUN9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function DUF87	MA20_26515	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
k59_1080818_1	335543.Sfum_4031	7.26e-31	120.0	COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,42N23@68525|delta/epsilon subdivisions,2WKW2@28221|Deltaproteobacteria,2MSIP@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM ABC transporter, transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
k59_1080818_2	941449.dsx2_3087	1.24e-51	169.0	COG0664@1|root,COG0664@2|Bacteria,1RI6M@1224|Proteobacteria,42U8A@68525|delta/epsilon subdivisions,2WPZ6@28221|Deltaproteobacteria,2MCCN@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM Cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_135196_1	1123399.AQVE01000019_gene1570	2.08e-47	172.0	COG4191@1|root,COG4191@2|Bacteria,1R969@1224|Proteobacteria	1224|Proteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_8
k59_545383_1	522306.CAP2UW1_1859	8.31e-73	230.0	COG3458@1|root,COG3458@2|Bacteria,1Q243@1224|Proteobacteria	1224|Proteobacteria	Q	PFAM Acetyl xylan esterase	-	-	3.1.1.41	ko:K01060	ko00311,ko01130,map00311,map01130	-	R03062	RC00020,RC00041	ko00000,ko00001,ko01000	-	-	-	AXE1
k59_27481_1	1123399.AQVE01000007_gene1162	7.78e-43	150.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,460BJ@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_27481_2	768671.ThimaDRAFT_2166	1.02e-20	85.1	COG1393@1|root,COG1393@2|Bacteria,1MZ6S@1224|Proteobacteria,1S8TR@1236|Gammaproteobacteria,1WYR9@135613|Chromatiales	135613|Chromatiales	P	Belongs to the ArsC family	-	-	-	-	-	-	-	-	-	-	-	-	ArsC
k59_1661867_1	1408444.JHYC01000002_gene626	2.34e-44	157.0	COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1JDJ6@118969|Legionellales	118969|Legionellales	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA_2
k59_1661867_2	631362.Thi970DRAFT_03277	8.11e-123	363.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,1WWB0@135613|Chromatiales	135613|Chromatiales	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
k59_1426962_2	1196835.A458_19040	6.11e-55	174.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria,1Z1TP@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019103,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0051259,GO:0051260,GO:0055086,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
k59_27485_1	765912.Thimo_3632	8.42e-105	307.0	COG1943@1|root,COG1943@2|Bacteria,1P8IT@1224|Proteobacteria,1RSQC@1236|Gammaproteobacteria,1WWSI@135613|Chromatiales	135613|Chromatiales	L	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
k59_777592_1	351348.Maqu_0343	1.48e-58	189.0	COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,1RQB7@1236|Gammaproteobacteria,46461@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG1177 ABC-type spermidine putrescine transport system, permease component II	potC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015399,GO:0015405,GO:0015417,GO:0015595,GO:0015606,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0015848,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098533,GO:0098655,GO:0098796,GO:0098797,GO:1902047,GO:1902494,GO:1902495,GO:1903711,GO:1904949,GO:1990351	-	ko:K11070,ko:K11074	ko02010,map02010	M00299,M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1,3.A.1.11.2	-	iSBO_1134.SBO_1939	BPD_transp_1
k59_777592_2	1354303.M917_1816	3.6e-14	71.2	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,1RNNZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ABC-type spermidine putrescine transport system, permease component I	potB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015399,GO:0015405,GO:0015417,GO:0015595,GO:0015606,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0015848,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098533,GO:0098655,GO:0098796,GO:0098797,GO:1902047,GO:1902494,GO:1902495,GO:1903711,GO:1904949,GO:1990351	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	iE2348C_1286.E2348C_1266,iECUMN_1333.ECUMN_1368,iSBO_1134.SBO_1916	BPD_transp_1
k59_486803_1	1415780.JPOG01000001_gene394	2.95e-22	88.2	COG3785@1|root,COG3785@2|Bacteria,1RHM7@1224|Proteobacteria,1T11M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Hemimethylated DNA-binding protein YccV like	-	-	-	ko:K11940	-	-	-	-	ko00000,ko03036	-	-	-	YccV-like
k59_486803_2	880071.Fleli_4038	2.28e-15	75.9	COG1047@1|root,COG1047@2|Bacteria,4NM29@976|Bacteroidetes,47PG1@768503|Cytophagia	976|Bacteroidetes	O	Peptidyl-prolyl cis-trans isomerase	fkpB	-	5.2.1.8	ko:K01802,ko:K03774	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
k59_428730_2	1081644.IMCC13023_02670	3.43e-08	53.1	COG2335@1|root,COG2335@2|Bacteria,2GJC2@201174|Actinobacteria,4FNZN@85023|Microbacteriaceae	201174|Actinobacteria	M	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	mpt	GO:0005575,GO:0005576,GO:0005615,GO:0005623,GO:0005886,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043207,GO:0044403,GO:0044419,GO:0044421,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071944,GO:0075136	-	-	-	-	-	-	-	-	-	-	Fasciclin
k59_664148_1	998674.ATTE01000001_gene1704	5.98e-55	186.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,460C8@72273|Thiotrichales	72273|Thiotrichales	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_664149_1	1336249.JADW01000039_gene67	2.39e-44	159.0	COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,2TT84@28211|Alphaproteobacteria,4B8PF@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0061 (SELO) family	-	-	-	ko:K08997	-	-	-	-	ko00000	-	-	-	UPF0061
k59_1255808_1	396588.Tgr7_0259	6.88e-98	310.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1WXPW@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
k59_1368096_1	1288826.MSNKSG1_09403	4.8e-153	448.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,464P4@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_1131040_1	1267005.KB911264_gene3189	1.35e-121	365.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,3N86I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Extracellular solute-binding protein	nikA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1662572_1	269084.syc0898_c	2.86e-75	241.0	COG0129@1|root,COG0129@2|Bacteria,1G0KD@1117|Cyanobacteria,1GYPT@1129|Synechococcus	1117|Cyanobacteria	H	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_722602_1	1036674.A28LD_0559	3.45e-33	122.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,2QFA6@267893|Idiomarinaceae	1236|Gammaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666	ATP-synt_A
k59_722602_2	95619.PM1_0229060	1.08e-28	105.0	COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,1S9MD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_722602_3	318167.Sfri_4049	9.34e-35	125.0	COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,1S402@1236|Gammaproteobacteria,2QADG@267890|Shewanellaceae	1236|Gammaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031225,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	e_coli_core.b3736,iAF1260.b3736,iB21_1397.B21_03564,iBWG_1329.BWG_3427,iE2348C_1286.E2348C_4046,iEC042_1314.EC042_4123,iEC55989_1330.EC55989_4211,iECABU_c1320.ECABU_c42210,iECBD_1354.ECBD_4296,iECB_1328.ECB_03620,iECDH10B_1368.ECDH10B_3923,iECDH1ME8569_1439.ECDH1ME8569_3624,iECD_1391.ECD_03620,iECED1_1282.ECED1_4426,iECH74115_1262.ECH74115_5172,iECIAI1_1343.ECIAI1_3920,iECIAI39_1322.ECIAI39_4340,iECO103_1326.ECO103_4422,iECO111_1330.ECO111_4570,iECO26_1355.ECO26_4842,iECOK1_1307.ECOK1_4185,iECP_1309.ECP_3935,iECS88_1305.ECS88_4158,iECSE_1348.ECSE_4026,iECSF_1327.ECSF_3584,iECSP_1301.ECSP_4786,iECUMN_1333.ECUMN_4266,iECW_1372.ECW_m4039,iECs_1301.ECs4678,iEKO11_1354.EKO11_4609,iETEC_1333.ETEC_4027,iEcDH1_1363.EcDH1_4231,iEcE24377_1341.EcE24377A_4252,iEcHS_1320.EcHS_A3952,iEcSMS35_1347.EcSMS35_4104,iEcolC_1368.EcolC_4258,iG2583_1286.G2583_4532,iJO1366.b3736,iJR904.b3736,iSDY_1059.SDY_4012,iSFV_1184.SFV_3762,iSF_1195.SF3816,iSFxv_1172.SFxv_4159,iSSON_1240.SSON_3883,iS_1188.S3952,iSbBS512_1146.SbBS512_E4185,iUMN146_1321.UM146_18870,iUMNK88_1353.UMNK88_4548,iUTI89_1310.UTI89_C4291,iWFL_1372.ECW_m4039,iY75_1357.Y75_RS18390,iZ_1308.Z5234,ic_1306.c4664	ATP-synt_B
k59_1497269_1	1203568.HMPREF1484_00301	1.69e-23	110.0	COG1276@1|root,COG1276@2|Bacteria,2I2PE@201174|Actinobacteria,4FBCZ@85020|Dermabacteraceae	201174|Actinobacteria	P	Copper resistance protein D	-	-	-	ko:K02351,ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	Caa3_CtaG,CopD
k59_1088677_1	1385517.N800_13180	2.55e-44	165.0	COG2373@1|root,COG4932@1|root,COG2373@2|Bacteria,COG4932@2|Bacteria,1QZFW@1224|Proteobacteria	1224|Proteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
k59_669538_2	871585.BDGL_003043	8.97e-13	76.3	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,3NM9J@468|Moraxellaceae	1236|Gammaproteobacteria	GM	Outer membrane lipoprotein-sorting protein	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	LolA_like,MMPL,Polyketide_cyc2
k59_141306_1	484018.BACPLE_00382	6.3e-40	145.0	COG1162@1|root,COG1162@2|Bacteria,4NE5H@976|Bacteroidetes,2FNY9@200643|Bacteroidia,4ANQ4@815|Bacteroidaceae	976|Bacteroidetes	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase,RsgA_N
k59_610337_1	1049564.TevJSym_ao00080	2.2e-76	236.0	COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	sugar kinase	adoK	-	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_915272_1	1120956.JHZK01000024_gene1075	2.68e-18	89.4	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,2TS37@28211|Alphaproteobacteria,1JNCG@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
k59_271431_2	1265505.ATUG01000001_gene4312	1.67e-07	50.8	COG5598@1|root,COG5598@2|Bacteria,1NY0Q@1224|Proteobacteria,430P1@68525|delta/epsilon subdivisions,2WVPQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
k59_1783697_2	757424.Hsero_2383	3.47e-06	50.4	COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,2VJIQ@28216|Betaproteobacteria,475ZM@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
k59_1783697_3	1038859.AXAU01000001_gene2680	7.9e-36	133.0	COG0845@1|root,COG0845@2|Bacteria,1Q10W@1224|Proteobacteria,2TSC8@28211|Alphaproteobacteria,3JT5F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Evidence Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3
k59_199872_1	1120941.AUBL01000009_gene795	1.28e-71	233.0	COG0213@1|root,COG0295@1|root,COG0213@2|Bacteria,COG0295@2|Bacteria,2GJH5@201174|Actinobacteria,4D329@85005|Actinomycetales	201174|Actinobacteria	F	phosphorylase	deoA	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
k59_1725715_1	314278.NB231_17298	9.99e-65	204.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,1RPK3@1236|Gammaproteobacteria,1WWEP@135613|Chromatiales	135613|Chromatiales	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
k59_1725715_2	243233.MCA1057	6.14e-71	221.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,1XEUB@135618|Methylococcales	135618|Methylococcales	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_1433396_1	1335757.SPICUR_07935	1.24e-18	80.1	COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,1S8VY@1236|Gammaproteobacteria,1WZ25@135613|Chromatiales	135613|Chromatiales	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
k59_1433396_2	754476.Q7A_2836	6.11e-196	550.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,4602K@72273|Thiotrichales	72273|Thiotrichales	D	TIGRFAM Cell shape determining protein MreB Mrl	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_386978_1	765913.ThidrDRAFT_4303	1.28e-122	360.0	COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,1RMJC@1236|Gammaproteobacteria,1WWJN@135613|Chromatiales	135613|Chromatiales	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	-	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
k59_915302_1	929556.Solca_3240	3.5e-72	239.0	COG1770@1|root,COG1770@2|Bacteria,4NEQS@976|Bacteroidetes,1IQQY@117747|Sphingobacteriia	976|Bacteroidetes	E	Peptidase S9, prolyl oligopeptidase, catalytic domain	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_434298_2	558173.CDOO_05345	9.07e-06	50.8	COG0421@1|root,COG0421@2|Bacteria,2GN8I@201174|Actinobacteria,22MYJ@1653|Corynebacteriaceae	201174|Actinobacteria	E	spermidine synthase	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Spermine_synth
k59_1497302_1	69042.WH5701_08409	1.81e-32	123.0	COG3187@1|root,COG3187@2|Bacteria,1GAVD@1117|Cyanobacteria	1117|Cyanobacteria	O	Heat shock protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1262831_1	1122933.JNIY01000003_gene591	1.29e-41	153.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,4F22I@85016|Cellulomonadaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iNJ661.Rv3152	NADHdh
k59_317303_1	765912.Thimo_1256	5.6e-78	254.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales	135613|Chromatiales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_610357_1	768671.ThimaDRAFT_4355	1.69e-53	187.0	COG5421@1|root,COG5421@2|Bacteria,1R6MI@1224|Proteobacteria,1SKFJ@1236|Gammaproteobacteria,1X099@135613|Chromatiales	135613|Chromatiales	L	COG0841 Cation multidrug efflux pump	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_669566_1	313589.JNB_09404	1.62e-27	103.0	COG0853@1|root,COG0853@2|Bacteria,2IHTC@201174|Actinobacteria,4FGGN@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
k59_141333_1	234267.Acid_1048	8.85e-85	280.0	COG4913@1|root,COG4913@2|Bacteria	2|Bacteria	D	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SbcCD_C
k59_317306_1	351348.Maqu_1945	8.54e-17	78.6	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,464XH@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0714 MoxR-like ATPases	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_317306_2	631362.Thi970DRAFT_03275	4.09e-60	197.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1WWS2@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_783085_1	314278.NB231_15453	9.96e-20	90.9	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1WX8Q@135613|Chromatiales	135613|Chromatiales	M	Cell wall hydrolase autolysin	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,LysM
k59_318038_1	748658.KB907312_gene1966	2.86e-24	107.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_435019_1	1121403.AUCV01000056_gene3012	4.22e-68	225.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MHU5@213118|Desulfobacterales	28221|Deltaproteobacteria	S	pfam abc-1	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
k59_493809_1	768671.ThimaDRAFT_3304	2.65e-118	347.0	28I2K@1|root,2Z86N@2|Bacteria,1R1GA@1224|Proteobacteria,1RRPU@1236|Gammaproteobacteria,1WXHU@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1327882_1	935548.KI912159_gene2061	7.15e-91	277.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2U071@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	1.14.15.7	ko:K00499	ko00260,map00260	-	R07409	RC00087	ko00000,ko00001,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
k59_1137025_1	768671.ThimaDRAFT_1867	1.05e-109	326.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,1WWUF@135613|Chromatiales	135613|Chromatiales	S	PFAM Patatin	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_1856183_1	1232410.KI421425_gene1554	5.62e-85	281.0	COG1361@1|root,COG1361@2|Bacteria,1R5G4@1224|Proteobacteria,42T0V@68525|delta/epsilon subdivisions,2WPRT@28221|Deltaproteobacteria,43TPS@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
k59_1608081_1	1038860.AXAP01000101_gene5274	1.33e-90	288.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1608084_2	1123368.AUIS01000009_gene2470	5.51e-41	147.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	gltP	-	-	ko:K03309	-	-	-	-	ko00000	2.A.23	-	-	SDF
k59_1549936_1	2340.JV46_03220	1.74e-28	112.0	COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,1RYFC@1236|Gammaproteobacteria,1J6QH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	HPP family	-	-	-	ko:K07168	-	-	-	-	ko00000	-	-	-	HPP
k59_1549936_2	1395516.PMO01_05935	1.54e-64	209.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_670296_2	1232410.KI421424_gene1751	2.94e-16	77.4	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,42NS9@68525|delta/epsilon subdivisions,2WJMJ@28221|Deltaproteobacteria,43SCR@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_94837_1	572477.Alvin_3113	7.1e-78	253.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1WX60@135613|Chromatiales	135613|Chromatiales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_1374049_1	1229780.BN381_180029	2.37e-59	200.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria	201174|Actinobacteria	S	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1608094_1	1122604.JONR01000009_gene2339	6.24e-17	85.1	COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,1RPTU@1236|Gammaproteobacteria,1X4KY@135614|Xanthomonadales	135614|Xanthomonadales	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_38952_1	1267005.KB911257_gene914	7.59e-40	149.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2TS8V@28211|Alphaproteobacteria,3N6G9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	FtsX-like permease family	MA20_43810	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_975727_1	706587.Desti_2078	8.03e-123	366.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,42MVQ@68525|delta/epsilon subdivisions,2WJRN@28221|Deltaproteobacteria,2MRE7@213462|Syntrophobacterales	28221|Deltaproteobacteria	CO	cytochrome c biogenesis protein, transmembrane region	dbsD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbD,Thioredoxin,Thioredoxin_2,Thioredoxin_7
k59_1726521_1	395493.BegalDRAFT_0424	1.77e-257	719.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,463UV@72273|Thiotrichales	72273|Thiotrichales	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	-	-	1.12.5.1	ko:K05922	-	-	-	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
k59_1327938_1	768671.ThimaDRAFT_2284	6.15e-125	372.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1WWI2@135613|Chromatiales	135613|Chromatiales	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_1856230_1	321846.PS417_06715	3.44e-69	216.0	COG3485@1|root,COG3485@2|Bacteria,1MUYX@1224|Proteobacteria,1RQHU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	protocatechuate 3,4-dioxygenase	pcaH	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C,PCDO_beta_N
k59_1434183_1	1049564.TevJSym_bo00090	1.12e-128	381.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,1RR3N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG2010 Cytochrome c, mono- and diheme variants	nirN	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_1137054_1	765912.Thimo_1059	2.31e-64	205.0	COG1011@1|root,COG1011@2|Bacteria,1N0I6@1224|Proteobacteria,1RQ41@1236|Gammaproteobacteria,1WXEC@135613|Chromatiales	135613|Chromatiales	S	subfamily IA, variant 1	-	-	3.1.3.102,3.1.3.104	ko:K20862	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00548,R07280	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2
k59_1374061_1	637389.Acaty_c1617	3.85e-80	257.0	COG3436@1|root,COG3436@2|Bacteria,1MYAC@1224|Proteobacteria,1T2KH@1236|Gammaproteobacteria,2NDQG@225057|Acidithiobacillales	225057|Acidithiobacillales	L	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66
k59_493852_1	981369.JQMJ01000004_gene2461	1.34e-75	237.0	COG0484@1|root,COG0484@2|Bacteria,2GK69@201174|Actinobacteria,2NEI6@228398|Streptacidiphilus	201174|Actinobacteria	O	DnaJ central domain	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_142095_1	1298863.AUEP01000013_gene4079	3.4e-61	197.0	COG0010@1|root,COG0010@2|Bacteria,2GJA6@201174|Actinobacteria,4DPV9@85009|Propionibacteriales	201174|Actinobacteria	E	Arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
k59_1327960_1	631362.Thi970DRAFT_02462	1.15e-75	238.0	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,1S02U@1236|Gammaproteobacteria,1WX9F@135613|Chromatiales	135613|Chromatiales	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
k59_1669044_1	257313.BP2962	1.99e-07	50.1	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2VQ07@28216|Betaproteobacteria,3T3Q0@506|Alcaligenaceae	28216|Betaproteobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
k59_1669044_2	1245471.PCA10_10580	1.46e-62	194.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,1S3Q7@1236|Gammaproteobacteria,1YFU2@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	J	Ribosomal protein S9/S16	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
k59_1374070_1	1089551.KE386572_gene4695	3.69e-44	149.0	COG0735@1|root,COG0735@2|Bacteria,1MZIW@1224|Proteobacteria,2U9G4@28211|Alphaproteobacteria,4BTBX@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Ferric uptake regulator family	MA20_23250	-	-	ko:K09823	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	FUR
k59_1374070_2	768671.ThimaDRAFT_3520	9.04e-27	106.0	COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,1RPYF@1236|Gammaproteobacteria,1WX5H@135613|Chromatiales	135613|Chromatiales	P	pfam abc-3	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
k59_728836_1	382464.ABSI01000006_gene877	6.27e-21	91.7	COG1070@1|root,COG1070@2|Bacteria,46SI1@74201|Verrucomicrobia,2IUMH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	FGGY family of carbohydrate kinases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
k59_728836_2	382464.ABSI01000006_gene876	6.3e-62	200.0	COG1917@1|root,COG4977@1|root,COG1917@2|Bacteria,COG4977@2|Bacteria,46WR3@74201|Verrucomicrobia,2IUSB@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1726543_1	933262.AXAM01000032_gene676	1.18e-19	88.2	COG0515@1|root,COG0515@2|Bacteria,1RI1E@1224|Proteobacteria	1224|Proteobacteria	KLT	Lipopolysaccharide kinase (Kdo/WaaP) family	waaP1	-	-	-	-	-	-	-	-	-	-	-	Kdo
k59_1726543_2	1280946.HY29_11100	1.08e-06	52.4	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,2TUTN@28211|Alphaproteobacteria,43X2R@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	COG0859 ADP-heptose LPS heptosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
k59_1434195_2	231434.JQJH01000019_gene721	6.18e-26	101.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,2TRHB@28211|Alphaproteobacteria,3N9YW@45404|Beijerinckiaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_783736_2	189425.PGRAT_28115	2.63e-19	83.2	COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,4HNNA@91061|Bacilli,26ZAP@186822|Paenibacillaceae	91061|Bacilli	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
k59_1608118_1	768671.ThimaDRAFT_1019	3.61e-59	193.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1WWBT@135613|Chromatiales	135613|Chromatiales	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_1608118_2	105559.Nwat_0223	1.31e-75	245.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1WWTC@135613|Chromatiales	135613|Chromatiales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1137067_1	926560.KE387027_gene1073	1.7e-15	83.6	COG1503@1|root,COG1503@2|Bacteria,1WJ3F@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach
k59_435074_1	316067.Geob_3320	1.65e-133	392.0	COG1379@1|root,COG1379@2|Bacteria,1QYWZ@1224|Proteobacteria,43CDU@68525|delta/epsilon subdivisions,2X7PS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1856286_1	575586.HMPREF0016_01005	3.92e-26	111.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,3NK7J@468|Moraxellaceae	1236|Gammaproteobacteria	I	Phospholipase D	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_1726555_1	1249627.D779_1787	6.69e-93	295.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales	135613|Chromatiales	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HTH_12,OB_RNB,RNB,S1
k59_1669059_1	1229205.BUPH_03712	3.13e-106	320.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2VH57@28216|Betaproteobacteria,1K11D@119060|Burkholderiaceae	28216|Betaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_1434212_1	396588.Tgr7_3124	2.08e-36	139.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,1WWBM@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
k59_1726560_1	335543.Sfum_2411	4.44e-90	275.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MR9A@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
k59_435080_1	1304883.KI912532_gene953	1.68e-106	331.0	COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,2VIV2@28216|Betaproteobacteria,2KVXE@206389|Rhodocyclales	206389|Rhodocyclales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_728859_1	458817.Shal_0042	6.15e-12	70.5	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,2QAS9@267890|Shewanellaceae	1236|Gammaproteobacteria	D	Peptidase M23B	envC	GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1328012_2	1144343.PMI41_04797	5.77e-32	117.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2U7D8@28211|Alphaproteobacteria,43JTD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Oligoketide cyclase lipid transport protein	pasT	-	-	ko:K18588	-	-	-	-	ko00000	-	-	-	Polyketide_cyc
k59_670351_2	156978.CIMIT_12055	1.9e-23	100.0	COG0385@1|root,COG0385@2|Bacteria,2GJQU@201174|Actinobacteria,22KCW@1653|Corynebacteriaceae	201174|Actinobacteria	S	Na -dependent transporter	-	-	-	ko:K14347	-	-	-	-	ko00000,ko02000,ko04147	2.A.93.1	-	-	SBF_like
k59_1018657_1	1121405.dsmv_2460	2.39e-15	75.1	COG0492@1|root,COG0526@1|root,COG0492@2|Bacteria,COG0526@2|Bacteria,1R05R@1224|Proteobacteria,42QEV@68525|delta/epsilon subdivisions,2WMBG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Thioredoxin_3
k59_1018657_2	335543.Sfum_1747	5.48e-46	153.0	2DWSR@1|root,341Q6@2|Bacteria,1Q538@1224|Proteobacteria,430G3@68525|delta/epsilon subdivisions,2WVK2@28221|Deltaproteobacteria,2MRYW@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1089560_1	1121937.AUHJ01000050_gene1243	8.95e-177	501.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,1RMHK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG3385 FOG Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_1089561_2	414684.RC1_2026	5e-38	141.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2TSDP@28211|Alphaproteobacteria,2JQ32@204441|Rhodospirillales	204441|Rhodospirillales	L	Belongs to the DNA photolyase family	phrB	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_39026_1	177437.HRM2_30480	1.18e-31	116.0	COG1664@1|root,COG1664@2|Bacteria,1QN6Q@1224|Proteobacteria,42SWT@68525|delta/epsilon subdivisions,2WPH2@28221|Deltaproteobacteria,2MK42@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_916750_1	933262.AXAM01000050_gene3482	2.29e-104	320.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42NCR@68525|delta/epsilon subdivisions,2WKMY@28221|Deltaproteobacteria,2MHTZ@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1503658_2	204773.HEAR1472	1.85e-34	125.0	COG4799@1|root,COG4799@2|Bacteria,1NRN3@1224|Proteobacteria,2VJ5W@28216|Betaproteobacteria,472WS@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Malonate decarboxylase gamma subunit (MdcE)	mdcE	-	4.1.1.87	ko:K13933	-	-	-	-	ko00000,ko01000	-	-	-	MdcE
k59_1674204_1	706587.Desti_2952	1.98e-178	518.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42MQS@68525|delta/epsilon subdivisions,2WINP@28221|Deltaproteobacteria,2MR0I@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	PFAM Enoyl-CoA hydratase isomerase	-	-	1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8	ko:K01782,ko:K01825	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_1204159_2	1167006.UWK_01449	4.14e-40	142.0	COG1309@1|root,COG1309@2|Bacteria,1PHGD@1224|Proteobacteria,43DZQ@68525|delta/epsilon subdivisions,2WZAD@28221|Deltaproteobacteria,2MM92@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_45958_1	1121422.AUMW01000020_gene1727	5.54e-99	301.0	COG4799@1|root,COG4799@2|Bacteria,1TQCV@1239|Firmicutes,247WG@186801|Clostridia,25ZXW@186807|Peptococcaceae	186801|Clostridia	I	acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	gcdA	-	4.1.1.70	ko:K01615	ko00362,ko00650,ko01120,map00362,map00650,map01120	-	R03028	RC00832	ko00000,ko00001,ko01000,ko02000	3.B.1.1.3	-	-	Carboxyl_trans
k59_787964_1	1266925.JHVX01000003_gene635	5.1e-64	206.0	COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,2VKAU@28216|Betaproteobacteria,372AN@32003|Nitrosomonadales	28216|Betaproteobacteria	P	TIGRFAM phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like,PBP_like_2
k59_616206_1	1122604.JONR01000001_gene1694	4.94e-16	80.1	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1RN7K@1236|Gammaproteobacteria,1X5D0@135614|Xanthomonadales	135614|Xanthomonadales	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_984723_1	1382306.JNIM01000001_gene3126	4.34e-60	204.0	COG0683@1|root,COG0683@2|Bacteria,2G6Q1@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_984723_2	269799.Gmet_0995	3.91e-10	60.1	COG2853@1|root,COG2853@2|Bacteria,1QV20@1224|Proteobacteria	1224|Proteobacteria	M	Lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_147383_1	566466.NOR53_798	1.56e-71	229.0	COG2391@1|root,COG2391@2|Bacteria,1RIWE@1224|Proteobacteria,1S93K@1236|Gammaproteobacteria,1J96D@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Rhodanese,Sulf_transp
k59_323235_1	33898.JRHJ01000078_gene937	3.27e-63	211.0	COG3848@1|root,COG3848@2|Bacteria,2H2J1@201174|Actinobacteria	201174|Actinobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
k59_1336933_1	768671.ThimaDRAFT_3701	2.65e-36	131.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,1X0CI@135613|Chromatiales	135613|Chromatiales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1269300_1	472759.Nhal_2390	5.22e-33	116.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,1S5XT@1236|Gammaproteobacteria,1WYH7@135613|Chromatiales	135613|Chromatiales	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_1731619_1	882083.SacmaDRAFT_1244	3.28e-180	513.0	COG1350@1|root,COG1350@2|Bacteria,2GP7D@201174|Actinobacteria,4DZNN@85010|Pseudonocardiales	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB2	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_45973_1	338969.Rfer_1278	3.97e-33	134.0	COG3206@1|root,COG4974@1|root,COG3206@2|Bacteria,COG4974@2|Bacteria,1NRKW@1224|Proteobacteria,2VR08@28216|Betaproteobacteria	28216|Betaproteobacteria	LM	viral genome integration into host DNA	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
k59_1865222_1	1434929.X946_4397	1.02e-06	50.1	COG1070@1|root,COG1070@2|Bacteria,1R7FN@1224|Proteobacteria,2W1J5@28216|Betaproteobacteria,1K259@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Carbohydrate kinase	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
k59_1865222_2	298655.KI912266_gene5704	1.79e-36	135.0	COG0524@1|root,COG0524@2|Bacteria,2I04R@201174|Actinobacteria,4ET61@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_1269307_1	1121405.dsmv_1030	2.56e-25	108.0	COG1413@1|root,COG1413@2|Bacteria,1NDC5@1224|Proteobacteria,42VM1@68525|delta/epsilon subdivisions,2WRE6@28221|Deltaproteobacteria,2MMBT@213118|Desulfobacterales	28221|Deltaproteobacteria	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
k59_1613331_1	768671.ThimaDRAFT_0916	5.71e-50	176.0	COG4263@1|root,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,1RQSW@1236|Gammaproteobacteria,1WZYX@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c oxidase subunit	nosZ	-	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	COX2,Cupredoxin_1
k59_1613331_2	765912.Thimo_2810	2.19e-07	54.7	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,1S4KA@1236|Gammaproteobacteria,1WY97@135613|Chromatiales	135613|Chromatiales	C	PFAM Cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_147401_1	1255043.TVNIR_3142	5.16e-73	230.0	COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,1WWX2@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue	prmB	-	2.1.1.298	ko:K07320	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03009	-	-	-	MTS
k59_147401_2	1049564.TevJSym_av00440	2.79e-44	145.0	2E5B5@1|root,33039@2|Bacteria,1NDK8@1224|Proteobacteria,1SFKE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_205993_1	1245471.PCA10_40500	5.33e-39	139.0	COG1261@1|root,COG1261@2|Bacteria,1N1SA@1224|Proteobacteria,1S8SQ@1236|Gammaproteobacteria,1YFFT@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	N	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly	flgA	-	-	ko:K02386	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	ChapFlgA
k59_1865227_1	314345.SPV1_03238	8.64e-05	44.7	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria	1224|Proteobacteria	S	von Willebrand factor, type A	batA	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
k59_1555126_1	1385519.N801_10420	2.91e-87	285.0	COG0479@1|root,COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0479@2|Bacteria,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2I995@201174|Actinobacteria,4FITA@85021|Intrasporangiaceae	201174|Actinobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_323247_1	667014.Thein_1033	4.11e-72	229.0	COG1060@1|root,COG1060@2|Bacteria,2GH1Z@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
k59_1788728_1	439235.Dalk_2986	2.81e-36	136.0	COG0641@1|root,COG3012@1|root,COG0641@2|Bacteria,COG3012@2|Bacteria,1MX3M@1224|Proteobacteria,42PD2@68525|delta/epsilon subdivisions,2WJIK@28221|Deltaproteobacteria,2MN8H@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SEC-C,SPASM
k59_984766_1	765912.Thimo_2191	1.39e-16	80.1	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WVVT@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_984766_2	765911.Thivi_3577	6.6e-38	138.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,1WX9B@135613|Chromatiales	135613|Chromatiales	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	-	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Acetyltransf_1
k59_1379266_1	765911.Thivi_2976	1.14e-64	205.0	COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,1S3NG@1236|Gammaproteobacteria,1WY7S@135613|Chromatiales	135613|Chromatiales	S	SCO1 SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
k59_1788729_1	460265.Mnod_7565	2.41e-64	211.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,2TTZ4@28211|Alphaproteobacteria,1JRMV@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
k59_1503698_1	1266925.JHVX01000006_gene2138	3.12e-06	53.5	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2VJZP@28216|Betaproteobacteria,372EI@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
k59_1336982_1	768671.ThimaDRAFT_2158	1.86e-77	241.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1WXRN@135613|Chromatiales	135613|Chromatiales	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_1095037_1	716544.wcw_1965	1.54e-32	128.0	COG3278@1|root,COG3278@2|Bacteria,2JFEV@204428|Chlamydiae	204428|Chlamydiae	C	oxidase subunit 1	fixN	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_499070_1	62928.azo3304	8e-34	127.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,2KV6W@206389|Rhodocyclales	206389|Rhodocyclales	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
k59_499070_2	283699.D172_1326	9.38e-65	212.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,2PZQ3@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	-	1.10.3.10,1.9.3.1	ko:K02274,ko:K02298	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081,R11335	RC00016,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.5,3.D.4.6	-	iJN746.PP_0104	COX1
k59_984784_1	478741.JAFS01000002_gene64	7.04e-17	89.4	COG0782@1|root,COG1747@1|root,COG0782@2|Bacteria,COG1747@2|Bacteria,46S7F@74201|Verrucomicrobia,37FV9@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	K	Transcription elongation factor, N-terminal	greA	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB,GreA_GreB_N
k59_675717_1	1385519.N801_01035	2.1e-12	66.2	COG0514@1|root,COG0514@2|Bacteria,2GJSS@201174|Actinobacteria,4FET8@85021|Intrasporangiaceae	201174|Actinobacteria	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
k59_675717_2	367299.JOEE01000003_gene2792	8.94e-100	303.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4FEVT@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_984786_1	1231392.OCGS_1059	1.8e-11	69.7	COG0348@1|root,COG3901@1|root,COG0348@2|Bacteria,COG3901@2|Bacteria,1MY5M@1224|Proteobacteria,2TR0X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CK	COG3901 Regulator of nitric oxide reductase transcription	nosR	-	-	ko:K19339	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind,Fer4_5
k59_788007_1	1167006.UWK_03201	6.98e-09	58.5	COG0589@1|root,COG0589@2|Bacteria,1N9QR@1224|Proteobacteria,42VEI@68525|delta/epsilon subdivisions,2WRFX@28221|Deltaproteobacteria,2MKUR@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1095043_1	754477.Q7C_631	2.31e-43	149.0	COG2888@1|root,COG2888@2|Bacteria,1P9T7@1224|Proteobacteria,1RYIB@1236|Gammaproteobacteria,460Y8@72273|Thiotrichales	72273|Thiotrichales	J	Zinc-ribbon containing domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1451
k59_1379286_1	87626.PTD2_15732	7.4e-09	58.5	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,1RNH4@1236|Gammaproteobacteria,2Q05M@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	ybaL	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
k59_1379286_2	675806.VII_002471	1.85e-09	60.1	COG3713@1|root,COG3713@2|Bacteria,1MWQN@1224|Proteobacteria,1RQTM@1236|Gammaproteobacteria,1XV4Z@135623|Vibrionales	135623|Vibrionales	M	MltA-interacting protein MipA	ompV	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K07274	-	-	-	-	ko00000,ko02000	9.B.99.1	-	-	MipA
k59_1788743_1	1288963.ADIS_4698	4.01e-35	140.0	COG2905@1|root,COG2905@2|Bacteria,4NP1Y@976|Bacteroidetes,47PPN@768503|Cytophagia	976|Bacteroidetes	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_984799_1	203122.Sde_2829	5.92e-74	232.0	COG2850@1|root,COG2850@2|Bacteria,1MUAC@1224|Proteobacteria,1RQQP@1236|Gammaproteobacteria,465RI@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Cupin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_8
k59_397271_1	754477.Q7C_296	7.82e-63	203.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,45ZWB@72273|Thiotrichales	72273|Thiotrichales	G	Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides	nagZ	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
k59_397271_2	582744.Msip34_0966	4.65e-60	189.0	COG1376@1|root,COG1376@2|Bacteria,1RHBG@1224|Proteobacteria,2VQT7@28216|Betaproteobacteria,2KMQ4@206350|Nitrosomonadales	206350|Nitrosomonadales	S	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_46015_1	935839.JAGJ01000008_gene1693	1.84e-63	215.0	COG1200@1|root,COG1200@2|Bacteria,2GKA3@201174|Actinobacteria,4F372@85017|Promicromonosporaceae	201174|Actinobacteria	L	RecG wedge domain	recG	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge,tRNA_anti-codon
k59_147436_1	1049564.TevJSym_ab01850	1.15e-72	232.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,1J4XV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_147436_2	765912.Thimo_2319	2.09e-29	109.0	COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,1S94K@1236|Gammaproteobacteria,1X2H8@135613|Chromatiales	135613|Chromatiales	L	PFAM DNA polymerase III chi subunit, HolC	-	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
k59_1555740_2	713586.KB900536_gene582	1.03e-150	439.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,1RMB8@1236|Gammaproteobacteria,1WYRX@135613|Chromatiales	135613|Chromatiales	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
k59_1439951_1	1122603.ATVI01000006_gene103	0.000247	44.7	COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria,1X5H6@135614|Xanthomonadales	135614|Xanthomonadales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
k59_1613950_1	879212.DespoDRAFT_01479	2.04e-46	162.0	COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria,42VIF@68525|delta/epsilon subdivisions,2WRY1@28221|Deltaproteobacteria,2MQ11@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_788492_1	1286106.MPL1_10327	6.23e-100	310.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,45ZRU@72273|Thiotrichales	72273|Thiotrichales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_1379903_1	1144319.PMI16_00548	2.86e-86	269.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,4723N@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_148014_1	935839.JAGJ01000005_gene2682	1.3e-133	396.0	COG0628@1|root,COG0628@2|Bacteria,2GK0H@201174|Actinobacteria,4F3AM@85017|Promicromonosporaceae	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_148014_2	1370121.AUWS01000076_gene621	1.08e-37	135.0	COG0546@1|root,COG0546@2|Bacteria,2HFGX@201174|Actinobacteria,2335N@1762|Mycobacteriaceae	201174|Actinobacteria	S	IA, variant 1	nt5e	GO:0003674,GO:0003824,GO:0004672,GO:0004713,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018108,GO:0018193,GO:0018212,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0071704,GO:0140096,GO:1901564	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_1866227_1	1175306.GWL_44790	4.08e-08	54.3	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2VHJ1@28216|Betaproteobacteria,472DH@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_1866227_2	335541.Swol_1634	2.09e-10	65.9	COG0772@1|root,COG0772@2|Bacteria,1TPGH@1239|Firmicutes,247WS@186801|Clostridia,42JHY@68298|Syntrophomonadaceae	186801|Clostridia	M	Peptidoglycan polymerase that is essential for cell wall elongation	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_985791_1	991905.SL003B_0441	2.48e-60	210.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2TS8V@28211|Alphaproteobacteria,4BP6I@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	FtsX-like permease family	MA20_43810	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1095740_1	469381.Dpep_1939	1.14e-08	55.1	COG0090@1|root,COG0090@2|Bacteria,3TA22@508458|Synergistetes	508458|Synergistetes	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_1095740_2	1380390.JIAT01000011_gene2590	9.83e-34	119.0	COG0089@1|root,COG0089@2|Bacteria,2IQ7V@201174|Actinobacteria,4CQIU@84995|Rubrobacteria	84995|Rubrobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_1379913_1	935839.JAGJ01000027_gene2807	3.84e-65	213.0	COG0668@1|root,COG0668@2|Bacteria,2GMFK@201174|Actinobacteria,4F3ZW@85017|Promicromonosporaceae	201174|Actinobacteria	M	Mechanosensitive ion channel	mscS	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
k59_1270052_1	1026882.MAMP_02232	7.5e-87	270.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,45ZP9@72273|Thiotrichales	72273|Thiotrichales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_1141961_1	1304865.JAGF01000001_gene2457	1.32e-144	430.0	COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4F334@85016|Cellulomonadaceae	201174|Actinobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	nasC	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1379920_1	717785.HYPMC_4689	1.86e-72	224.0	COG0335@1|root,COG3743@1|root,COG0335@2|Bacteria,COG3743@2|Bacteria,1RH3A@1224|Proteobacteria,2U9DF@28211|Alphaproteobacteria,3N6WT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
k59_1504473_1	1185876.BN8_01125	1.43e-27	108.0	COG2908@1|root,COG2908@2|Bacteria,4NEF1@976|Bacteroidetes,47JQJ@768503|Cytophagia	976|Bacteroidetes	S	Calcineurin-like phosphoesterase	lpxH	-	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Metallophos,Metallophos_2
k59_985821_1	1304275.C41B8_01525	4.68e-19	89.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RR5W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA,MASE1,PAS_3,PAS_4,PAS_9,Pkinase
k59_734963_1	935839.JAGJ01000013_gene2885	4.8e-38	135.0	2E4WR@1|root,32C23@2|Bacteria,2HKD3@201174|Actinobacteria,4F4U3@85017|Promicromonosporaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PKD
k59_734963_2	1265310.CCBD010000064_gene1135	8.14e-20	95.1	COG1835@1|root,COG1835@2|Bacteria,2GN56@201174|Actinobacteria,234N5@1762|Mycobacteriaceae	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_499698_1	1123399.AQVE01000018_gene3357	5.08e-54	191.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,45ZQ7@72273|Thiotrichales	72273|Thiotrichales	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HTH_12,OB_RNB,RNB,S1
k59_441004_1	765912.Thimo_1114	2.13e-23	99.0	COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1WXNS@135613|Chromatiales	135613|Chromatiales	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA_2
k59_441004_2	768671.ThimaDRAFT_2778	2.48e-31	120.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,1WVYS@135613|Chromatiales	135613|Chromatiales	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
k59_1674916_1	1123065.ATWL01000005_gene1351	5.6e-83	259.0	COG0114@1|root,COG0114@2|Bacteria,2GKWY@201174|Actinobacteria	201174|Actinobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_985827_1	1089550.ATTH01000001_gene2120	3.44e-23	105.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,4NEP3@976|Bacteroidetes,1FIWT@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Pyruvate:ferredoxin oxidoreductase core domain II	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_104762_1	765911.Thivi_3975	2.69e-97	295.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1WVX6@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_46884_1	1089551.KE386572_gene1456	1.22e-25	122.0	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2TR45@28211|Alphaproteobacteria,4BQ67@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	TamB, inner membrane protein subunit of TAM complex	tamB	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
k59_1613992_1	1227739.Hsw_0771	4.76e-53	187.0	COG4631@1|root,COG4631@2|Bacteria,4PMEG@976|Bacteroidetes,47KPG@768503|Cytophagia	976|Bacteroidetes	F	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.17.1.4	ko:K13482	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1344708_1	1123368.AUIS01000006_gene590	1.06e-71	221.0	2BKU0@1|root,32FA8@2|Bacteria,1RJX5@1224|Proteobacteria,1SJ45@1236|Gammaproteobacteria,2NCXG@225057|Acidithiobacillales	225057|Acidithiobacillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1793043_1	398767.Glov_1719	3.51e-08	62.8	28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,42NZH@68525|delta/epsilon subdivisions,2WKHB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c bacterial	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_C7,Cytochrome_cB
k59_1344710_1	317013.NY99_19185	9.91e-48	164.0	COG1011@1|root,COG1011@2|Bacteria,1N0I6@1224|Proteobacteria,1RQ41@1236|Gammaproteobacteria,1X45A@135614|Xanthomonadales	135614|Xanthomonadales	S	Hydrolase	-	-	3.1.3.102,3.1.3.104	ko:K20862	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00548,R07280	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2,Hydrolase
k59_1026937_1	3988.XP_002520665.1	1.04e-38	147.0	COG1331@1|root,KOG2244@2759|Eukaryota,37MEB@33090|Viridiplantae,3GDX8@35493|Streptophyta,4JEBN@91835|fabids	35493|Streptophyta	O	Spermatogenesis-associated protein	-	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thioredox_DsbH
k59_562432_1	501479.ACNW01000058_gene4386	7.98e-61	204.0	COG2334@1|root,COG2334@2|Bacteria,1QV5C@1224|Proteobacteria,2U09Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH,PhoU
k59_111364_1	335543.Sfum_0020	3.97e-156	464.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2MQ92@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K01338,ko:K04076	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Lon_C
k59_933272_1	105559.Nwat_3126	3.8e-87	276.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1WW41@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_285821_1	501479.ACNW01000089_gene2450	1.36e-20	94.7	28HPH@1|root,2Z7XH@2|Bacteria,1Q80I@1224|Proteobacteria,2TVGE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1208949_1	273068.TTE1384	2.72e-51	167.0	COG0756@1|root,COG0756@2|Bacteria,1V6HX@1239|Firmicutes,24K3X@186801|Clostridia,42GTP@68295|Thermoanaerobacterales	186801|Clostridia	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
k59_1274985_1	497964.CfE428DRAFT_5143	4.23e-72	236.0	COG1960@1|root,COG1960@2|Bacteria,46TJY@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1028023_1	292.DM42_7346	6.47e-30	122.0	COG3501@1|root,COG4104@1|root,COG3501@2|Bacteria,COG4104@2|Bacteria,1MU7Q@1224|Proteobacteria,2VJDF@28216|Betaproteobacteria,1K160@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Rhs element Vgr	-	-	-	ko:K11904	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	Gp5_C,Phage_GPD
k59_153249_1	1121106.JQKB01000067_gene1792	3.72e-58	196.0	COG5433@1|root,COG5433@2|Bacteria,1MY25@1224|Proteobacteria,2U0Y8@28211|Alphaproteobacteria,2JVFX@204441|Rhodospirillales	204441|Rhodospirillales	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_1679832_1	765912.Thimo_2012	5.79e-60	201.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,1RPKA@1236|Gammaproteobacteria,1WXPP@135613|Chromatiales	135613|Chromatiales	G	pfam mofrl	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
k59_1737263_1	1247726.MIM_c28770	4.68e-32	130.0	COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,2VJDF@28216|Betaproteobacteria,3T2DD@506|Alcaligenaceae	28216|Betaproteobacteria	U	protein conserved in bacteria	-	-	-	ko:K11904	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	Gp5_C,Phage_GPD
k59_1028030_1	471853.Bcav_1874	3.25e-46	162.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_1028030_2	471856.Jden_1474	2.38e-27	103.0	2E6TR@1|root,331DK@2|Bacteria,2IQF8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1510099_1	439235.Dalk_3497	7.41e-96	298.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1QW1M@1224|Proteobacteria	1224|Proteobacteria	T	SMART PAS domain containing protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	-
k59_1793685_1	338963.Pcar_2435	4.38e-53	187.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WJRZ@28221|Deltaproteobacteria,43SWM@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_112464_1	768671.ThimaDRAFT_3200	8.9e-05	43.1	COG0298@1|root,COG0298@2|Bacteria,1N76Y@1224|Proteobacteria,1SCGX@1236|Gammaproteobacteria,1WZ96@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM hydrogenase assembly chaperone hypC hupF	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
k59_112464_2	768671.ThimaDRAFT_2618	1.58e-30	112.0	COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,1S5WG@1236|Gammaproteobacteria,1WYQN@135613|Chromatiales	135613|Chromatiales	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
k59_286985_1	1424334.W822_05425	3.49e-09	56.6	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,2VJ3V@28216|Betaproteobacteria,3T1TG@506|Alcaligenaceae	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_286985_2	640081.Dsui_0360	4.45e-43	141.0	COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,2VSDQ@28216|Betaproteobacteria,2KWNB@206389|Rhodocyclales	206389|Rhodocyclales	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
k59_112470_1	1504981.KO116_4105	3.88e-61	210.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XHBW@135619|Oceanospirillales	135619|Oceanospirillales	P	P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_1510112_1	1535422.ND16A_1280	3.2e-36	140.0	COG0265@1|root,COG0265@2|Bacteria,1RBDX@1224|Proteobacteria	1224|Proteobacteria	O	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_1,PDZ_2,Trypsin_2
k59_1737280_1	471853.Bcav_0379	4.34e-69	224.0	COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_1510116_1	247490.KSU1_C0740	4.27e-36	135.0	COG1208@1|root,COG1208@2|Bacteria,2J0B4@203682|Planctomycetes	203682|Planctomycetes	JM	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
k59_1209646_2	765911.Thivi_1778	2.26e-30	115.0	COG1390@1|root,COG1390@2|Bacteria,1R8BT@1224|Proteobacteria,1S1WN@1236|Gammaproteobacteria,1WXX4@135613|Chromatiales	135613|Chromatiales	C	V-type proton ATPase subunit E	-	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
k59_1385158_1	203122.Sde_2632	8.99e-88	276.0	COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,1RMER@1236|Gammaproteobacteria,4663Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 2 family	uidA	GO:0003674,GO:0003824,GO:0004553,GO:0004566,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016054,GO:0016137,GO:0016139,GO:0016787,GO:0016798,GO:0019389,GO:0019391,GO:0019752,GO:0022607,GO:0042802,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901136,GO:1901575,GO:1901657,GO:1901658	3.2.1.31	ko:K01195	ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01478,R04979,R07818,R08127,R08260,R10830	RC00055,RC00171,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_112485_1	1242864.D187_002372	5.51e-87	269.0	COG4143@1|root,COG4143@2|Bacteria,1R4IE@1224|Proteobacteria,42QHK@68525|delta/epsilon subdivisions,2WUK2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	(ABC) transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1793708_1	1133849.O3I_018070	6.55e-65	213.0	COG1680@1|root,COG1680@2|Bacteria,2GN1H@201174|Actinobacteria,4G8ND@85025|Nocardiaceae	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_563213_1	367299.JOEE01000012_gene3277	8.84e-99	297.0	COG0476@1|root,COG0476@2|Bacteria,2GJB6@201174|Actinobacteria,4FF9A@85021|Intrasporangiaceae	201174|Actinobacteria	H	The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are	moeB	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
k59_446013_1	926561.KB900620_gene2955	1.13e-92	292.0	COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia,3WA6E@53433|Halanaerobiales	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_621838_1	1122176.KB903553_gene3640	8.02e-107	327.0	COG0477@1|root,COG2814@2|Bacteria,4NE09@976|Bacteroidetes,1IP67@117747|Sphingobacteriia	976|Bacteroidetes	EGP	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
k59_1028073_1	1049564.TevJSym_be00160	8.66e-20	87.8	COG0810@1|root,COG0810@2|Bacteria,1MZ9F@1224|Proteobacteria,1T2GY@1236|Gammaproteobacteria,1J6IY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	TonB C terminal	tolA	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_2,TonB_C
k59_1560939_1	1121405.dsmv_0890	1.98e-49	172.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42MF0@68525|delta/epsilon subdivisions,2WMC1@28221|Deltaproteobacteria,2MIDP@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase for insertion sequences IS1326 IS1353 (IS21 IS408 IS1162 family protein)	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1275903_1	1123399.AQVE01000013_gene241	1.12e-74	233.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,1RN08@1236|Gammaproteobacteria,463N7@72273|Thiotrichales	1236|Gammaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_1874085_1	754476.Q7A_248	1.36e-59	195.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,461TR@72273|Thiotrichales	72273|Thiotrichales	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_1101309_2	472759.Nhal_2212	1.25e-27	104.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_1028082_1	1177154.Y5S_01713	1.5e-48	176.0	COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,1XI5R@135619|Oceanospirillales	135619|Oceanospirillales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
k59_1146508_1	1172179.AUKV01000009_gene4283	4.87e-26	113.0	COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria	201174|Actinobacteria	J	Ribosomal protein S1	rpsA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_504670_1	649638.Trad_1241	8.21e-36	139.0	COG0659@1|root,COG0659@2|Bacteria,1WM9X@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	STAS domain	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_856918_1	1449069.JMLO01000025_gene2402	6.11e-05	51.6	COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria,4FUXA@85025|Nocardiaceae	201174|Actinobacteria	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
k59_211671_1	1283300.ATXB01000001_gene738	6.29e-38	134.0	COG1833@1|root,COG1833@2|Bacteria,1N8Y1@1224|Proteobacteria,1SDIB@1236|Gammaproteobacteria,1XGWK@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function DUF123	-	-	-	-	-	-	-	-	-	-	-	-	DUF123
k59_446024_1	1121403.AUCV01000014_gene4573	2.52e-42	157.0	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,42PRD@68525|delta/epsilon subdivisions	1224|Proteobacteria	M	glycosyl transferase	ndvB	-	-	ko:K20541	-	-	-	-	ko00000,ko02000	4.D.3.1.6	-	-	BcsB,Glyco_hydro_17,Glyco_tranf_2_3,Glycos_transf_2
k59_287054_1	1335757.SPICUR_07315	1.05e-144	426.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1WW7K@135613|Chromatiales	135613|Chromatiales	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_1874106_1	985255.APHJ01000054_gene2086	4.68e-17	74.7	COG3668@1|root,COG3668@2|Bacteria,4NQ43@976|Bacteroidetes,1I3IS@117743|Flavobacteriia	976|Bacteroidetes	S	Belongs to the RelE toxin family	-	-	-	ko:K19092	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
k59_993526_1	1379698.RBG1_1C00001G0048	7.7e-64	206.0	COG1941@1|root,COG1941@2|Bacteria,2NQP6@2323|unclassified Bacteria	2|Bacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Fe_hyd_lg_C,Fer4,FlpD,Oxidored_q6
k59_1146514_1	1279019.ARQK01000031_gene1185	4.77e-97	317.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1WXIK@135613|Chromatiales	135613|Chromatiales	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_1510159_1	1122929.KB908220_gene2679	1.56e-60	201.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2U0K2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	N-acetylmuramoyl-L-alanine amidase	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
k59_1874110_1	1123400.KB904817_gene1533	5.97e-38	132.0	COG2138@1|root,COG2138@2|Bacteria,1N00J@1224|Proteobacteria,1SEQ6@1236|Gammaproteobacteria,462KV@72273|Thiotrichales	72273|Thiotrichales	S	CbiX	-	-	4.99.1.4	ko:K03794	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R02864	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	CbiX
k59_1874110_2	215803.DB30_4155	6.57e-74	233.0	COG0604@1|root,COG0604@2|Bacteria,1QY04@1224|Proteobacteria,43AHJ@68525|delta/epsilon subdivisions,2X5XS@28221|Deltaproteobacteria,2YUNY@29|Myxococcales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
k59_1560960_1	1035308.AQYY01000001_gene2357	1.06e-100	306.0	COG0539@1|root,COG0539@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,26081@186807|Peptococcaceae	186801|Clostridia	IJM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
k59_153314_2	391037.Sare_4979	1.18e-24	105.0	COG2865@1|root,COG2865@2|Bacteria,2I3IG@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
k59_112536_1	326424.FRAAL6785	5.8e-87	270.0	COG1929@1|root,COG1929@2|Bacteria,2GKHX@201174|Actinobacteria,4ETRP@85013|Frankiales	201174|Actinobacteria	G	Belongs to the glycerate kinase type-1 family	garK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
k59_1385207_1	309801.trd_1752	0.000515	43.1	COG1595@1|root,COG1595@2|Bacteria,2G6MG@200795|Chloroflexi,27YI4@189775|Thermomicrobia	189775|Thermomicrobia	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_740212_1	1385521.N803_06240	1.42e-102	304.0	2DPAW@1|root,331AG@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4262)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4262
k59_1345920_1	439235.Dalk_0097	9.21e-13	67.4	2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,42QRD@68525|delta/epsilon subdivisions,2WMYW@28221|Deltaproteobacteria,2MJGK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF4197)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4197
k59_1345920_2	521719.ATXQ01000003_gene1969	1.59e-40	153.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1YD67@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
k59_1679925_1	1304865.JAGF01000001_gene785	1.33e-104	321.0	COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria,4F12N@85016|Cellulomonadaceae	201174|Actinobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1444942_1	748658.KB907314_gene234	4.2e-40	150.0	COG0651@1|root,COG0651@2|Bacteria,1N6BY@1224|Proteobacteria,1RR4C@1236|Gammaproteobacteria,1WWFY@135613|Chromatiales	135613|Chromatiales	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_153345_1	1120944.JONS01000017_gene1520	9.13e-59	189.0	COG0503@1|root,COG0503@2|Bacteria,2IM7C@201174|Actinobacteria,4D3XC@85005|Actinomycetales	201174|Actinobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
k59_153345_2	562973.HMPREF0059_01667	2.63e-54	189.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4D3FH@85005|Actinomycetales	201174|Actinobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1510211_1	743721.Psesu_1766	3.41e-95	288.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1X3X9@135614|Xanthomonadales	135614|Xanthomonadales	F	Belongs to the CarA family	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_1146553_1	996637.SGM_4579	3.24e-14	72.8	2BWNB@1|root,32WFI@2|Bacteria,2IAXT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1146553_2	709986.Deima_1972	6.01e-49	172.0	COG2252@1|root,COG2252@2|Bacteria,1WM47@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Permease family	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
k59_1028175_1	1123355.JHYO01000010_gene3436	6.29e-19	87.4	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,36Y4A@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1028175_2	768671.ThimaDRAFT_1450	5.55e-46	158.0	COG2854@1|root,COG2854@2|Bacteria,1NUHS@1224|Proteobacteria,1SN8R@1236|Gammaproteobacteria,1X0Q3@135613|Chromatiales	135613|Chromatiales	Q	MlaC protein	-	-	-	-	-	-	-	-	-	-	-	-	MlaC
k59_112597_1	439235.Dalk_2281	2.98e-83	263.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42Z00@68525|delta/epsilon subdivisions,2WTI9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Nickel-dependent hydrogenase	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_792617_1	1120999.JONM01000006_gene2355	6.85e-44	156.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,2KPVY@206351|Neisseriales	206351|Neisseriales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_287158_1	864702.OsccyDRAFT_2115	1.32e-05	47.0	COG5548@1|root,COG5548@2|Bacteria,1G997@1117|Cyanobacteria,1HDDM@1150|Oscillatoriales	1117|Cyanobacteria	S	Transmembrane proteins 14C	-	-	-	-	-	-	-	-	-	-	-	-	Tmemb_14
k59_287158_2	765913.ThidrDRAFT_2991	1.9e-11	60.5	2AJN3@1|root,31A9F@2|Bacteria,1QMVM@1224|Proteobacteria,1TK62@1236|Gammaproteobacteria,1WZRM@135613|Chromatiales	135613|Chromatiales	S	Cysteine-rich CPXCG	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_CPXG
k59_856982_1	1319815.HMPREF0202_01595	1.69e-10	57.4	COG1757@1|root,COG1757@2|Bacteria	2|Bacteria	C	Na H antiporter	nhaC	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
k59_856982_2	686578.AFFX01000003_gene246	8.52e-77	248.0	COG0471@1|root,COG3273@1|root,COG0471@2|Bacteria,COG3273@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0471 Di- and tricarboxylate transporters	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_1625777_1	472759.Nhal_0594	6.12e-87	263.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,1WWE2@135613|Chromatiales	135613|Chromatiales	G	Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_1152638_1	1123065.ATWL01000003_gene882	4.61e-71	232.0	COG0480@1|root,COG0480@2|Bacteria,2GKB3@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1391752_1	1254432.SCE1572_24150	1.78e-89	280.0	2DSHD@1|root,33G4R@2|Bacteria	2|Bacteria	-	-	-	-	1.13.11.33	ko:K19246	ko00590,ko01100,map00590,map01100	-	R01593	RC00561	ko00000,ko00001,ko01000	-	-	-	Lipoxygenase
k59_629106_1	933262.AXAM01000011_gene1754	2.6e-39	135.0	COG1014@1|root,COG1014@2|Bacteria,1N12F@1224|Proteobacteria,42NN1@68525|delta/epsilon subdivisions,2WNNF@28221|Deltaproteobacteria,2MQ0Y@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
k59_1567550_1	396588.Tgr7_1277	1.84e-10	60.5	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,1RQBE@1236|Gammaproteobacteria,1WX20@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
k59_1567550_2	1283300.ATXB01000002_gene2571	4.37e-73	230.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,1XE69@135618|Methylococcales	135618|Methylococcales	OU	signal peptide peptidase SppA	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_336356_1	644801.Psest_0531	2.57e-72	230.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,1Z0Z0@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	T	phosphate starvation-inducible protein PhoH	ybeZ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_1036028_1	765911.Thivi_4511	8.59e-75	244.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,1RSAV@1236|Gammaproteobacteria,1WWWX@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_1567562_1	290399.Arth_2753	2.61e-21	93.6	COG0210@1|root,COG0210@2|Bacteria,2GKRW@201174|Actinobacteria,1W8G0@1268|Micrococcaceae	201174|Actinobacteria	L	UvrD-like helicase C-terminal domain	uvrD2	GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HRDC,UvrD-helicase,UvrD_C
k59_218307_2	926550.CLDAP_34480	8.47e-40	137.0	COG0315@1|root,COG0315@2|Bacteria,2G6PC@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
k59_863955_1	1235457.C404_17925	7.57e-08	53.1	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2VHCK@28216|Betaproteobacteria,1JZQY@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_863955_2	264198.Reut_A1035	8.95e-29	113.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2VIV0@28216|Betaproteobacteria,1K12C@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_453017_1	768670.Calni_1305	3.76e-33	125.0	COG1475@1|root,COG1475@2|Bacteria,2GF6J@200930|Deferribacteres	200930|Deferribacteres	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_1216703_1	710686.Mycsm_05421	3.73e-15	75.9	COG0071@1|root,COG0071@2|Bacteria,2IHVJ@201174|Actinobacteria,238NZ@1762|Mycobacteriaceae	201174|Actinobacteria	O	Belongs to the small heat shock protein (HSP20) family	hsp18	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_160087_1	911045.PSE_2454	3.47e-75	249.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	penicillin-binding protein	pbp	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
k59_1744720_1	1304865.JAGF01000001_gene3845	2.03e-68	221.0	COG0004@1|root,COG0004@2|Bacteria,2GIZK@201174|Actinobacteria,4F1S2@85016|Cellulomonadaceae	201174|Actinobacteria	P	Ammonium Transporter Family	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_1567582_1	1049564.TevJSym_ac01020	2.33e-143	422.0	COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,1RPDG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_1109348_2	1049564.TevJSym_bb00240	5.82e-60	198.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1J4PB@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_1517998_1	566461.SSFG_04107	9.05e-54	185.0	COG0168@1|root,COG0168@2|Bacteria,2GKKS@201174|Actinobacteria	201174|Actinobacteria	P	Potassium uptake protein	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_160100_1	1279015.KB908464_gene2096	3.67e-174	509.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,1Y45B@135624|Aeromonadales	135624|Aeromonadales	S	ABC transporter C-terminal domain	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_1391801_1	1095769.CAHF01000011_gene2556	7.09e-31	122.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,2VHWT@28216|Betaproteobacteria,475SR@75682|Oxalobacteraceae	28216|Betaproteobacteria	EGP	Nucleoside H+ symporter	hcaT	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
k59_1036064_1	1146883.BLASA_2019	2.7e-17	85.5	COG4961@1|root,COG4961@2|Bacteria,2I702@201174|Actinobacteria	201174|Actinobacteria	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
k59_1216723_1	472759.Nhal_0767	1.32e-09	59.7	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales	135613|Chromatiales	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
k59_1216723_2	1211114.ALIP01000084_gene1676	2.2e-54	184.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1X31B@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1283861_1	312153.Pnuc_0382	1.32e-56	189.0	COG0492@1|root,COG0492@2|Bacteria,1MW14@1224|Proteobacteria,2VGZS@28216|Betaproteobacteria,1K1VD@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Ferredoxin--NADP reductase	trxB2	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
k59_1625840_1	349161.Dred_1326	8.57e-25	102.0	COG2048@1|root,COG2048@2|Bacteria,1U4JW@1239|Firmicutes,24C8P@186801|Clostridia,260T4@186807|Peptococcaceae	186801|Clostridia	C	heterodisulfide reductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_1625840_2	1232410.KI421421_gene3255	1.47e-23	99.8	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,43THI@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	FAD dependent oxidoreductase	bamE	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7,Pyr_redox_2
k59_1391811_1	1267005.KB911256_gene2018	2.98e-149	442.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria,3N627@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Belongs to the ClpA ClpB family	clpA	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1283878_1	338963.Pcar_2557	1.62e-85	278.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,42Q00@68525|delta/epsilon subdivisions,2WJEM@28221|Deltaproteobacteria,43UHA@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Bifunctional transglycosylase second domain	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
k59_1283890_1	1190603.AJYD01000026_gene3255	6.96e-26	103.0	COG0406@1|root,COG0406@2|Bacteria,1N1NR@1224|Proteobacteria,1SBM5@1236|Gammaproteobacteria,1Y0P4@135623|Vibrionales	135623|Vibrionales	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_1567617_1	880072.Desac_2332	2.32e-103	316.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MAV@68525|delta/epsilon subdivisions,2WJC9@28221|Deltaproteobacteria,2MQSK@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	cimA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_160128_1	339670.Bamb_5250	4.73e-70	224.0	COG0665@1|root,COG0665@2|Bacteria,1MXD1@1224|Proteobacteria,2VKJ5@28216|Betaproteobacteria,1K0VS@119060|Burkholderiaceae	28216|Betaproteobacteria	E	fad dependent oxidoreductase	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
k59_1452055_1	335543.Sfum_3382	1.14e-06	49.7	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,43EVS@68525|delta/epsilon subdivisions,2X9S4@28221|Deltaproteobacteria,2MSFB@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_570244_2	717785.HYPMC_4886	2.68e-70	216.0	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2U5J1@28211|Alphaproteobacteria,3N6RB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Cobalamin adenosyltransferase	MA20_20540	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
k59_1452057_1	211114.JOEF01000002_gene4300	1.13e-13	75.1	COG0412@1|root,COG0412@2|Bacteria,2GKWS@201174|Actinobacteria,4E05E@85010|Pseudonocardiales	201174|Actinobacteria	Q	Chlorophyllase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Chlorophyllase,Chlorophyllase2,DLH
k59_797998_1	187303.BN69_3031	3.64e-34	134.0	COG1035@1|root,COG1035@2|Bacteria,1R45V@1224|Proteobacteria,2U2DM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Coenzyme F420-reducing hydrogenase, beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FrhB_FdhB_C,FrhB_FdhB_N
k59_1036103_2	512565.AMIS_49100	2.21e-12	70.1	COG1674@1|root,COG1716@1|root,COG1674@2|Bacteria,COG1716@2|Bacteria,2GJBR@201174|Actinobacteria	201174|Actinobacteria	D	DNA segregation ATPase FtsK SpoIIIE and related	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FHA,FtsK_SpoIIIE,Yop-YscD_cpl
k59_336447_1	1279038.KB907340_gene1700	1.17e-109	328.0	COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2TT1X@28211|Alphaproteobacteria,2JQBE@204441|Rhodospirillales	204441|Rhodospirillales	C	LUD domain	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_17,Fer4_8,LUD_dom
k59_1216765_1	593907.Celgi_2383	6.15e-149	437.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4F0HH@85016|Cellulomonadaceae	201174|Actinobacteria	E	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1452070_1	426114.THI_2132	2.94e-46	152.0	COG0537@1|root,COG0537@2|Bacteria,1N3EA@1224|Proteobacteria,2VSGA@28216|Betaproteobacteria	28216|Betaproteobacteria	FG	Histidine triad (Hit) protein	-	-	-	-	-	-	-	-	-	-	-	-	HIT
k59_570266_1	1286106.MPL1_09040	2.79e-27	108.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,4607C@72273|Thiotrichales	72273|Thiotrichales	E	Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K04518,ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
k59_570266_2	864051.BurJ1DRAFT_2067	6.56e-28	110.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2VIHG@28216|Betaproteobacteria,1KMB7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_1687034_2	1121939.L861_07830	1.54e-15	79.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1XI0C@135619|Oceanospirillales	135619|Oceanospirillales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
k59_1518092_1	102232.GLO73106DRAFT_00009610	4.55e-46	163.0	COG0531@1|root,COG0531@2|Bacteria,1G2GM@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_1110797_1	1282356.H045_20995	6.13e-77	237.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1YPTP@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	D	Chromosome partitioning protein	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_161257_1	933262.AXAM01000109_gene2063	9.92e-135	412.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WJ2A@28221|Deltaproteobacteria,2MI1M@213118|Desulfobacterales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_454067_1	572477.Alvin_0245	7.45e-125	375.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1WXKA@135613|Chromatiales	135613|Chromatiales	G	PFAM Alpha amylase, catalytic	-	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_1217853_1	631362.Thi970DRAFT_04432	2.89e-73	232.0	COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,1T2D1@1236|Gammaproteobacteria,1X28U@135613|Chromatiales	135613|Chromatiales	P	Sodium/hydrogen exchanger family	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger
k59_630226_1	886293.Sinac_3636	1.67e-50	185.0	COG0236@1|root,COG0764@1|root,COG1028@1|root,COG3266@1|root,COG3321@1|root,COG0236@2|Bacteria,COG0764@2|Bacteria,COG1028@2|Bacteria,COG3266@2|Bacteria,COG3321@2|Bacteria,2IY7E@203682|Planctomycetes	203682|Planctomycetes	IQ	Beta-ketoacyl synthase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
k59_1217864_1	1035308.AQYY01000001_gene1917	3.77e-96	290.0	COG1180@1|root,COG1180@2|Bacteria,1TP46@1239|Firmicutes,248K9@186801|Clostridia,2617J@186807|Peptococcaceae	186801|Clostridia	C	PFAM Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_798783_1	1034345.CAEM01000032_gene62	5.04e-20	97.4	COG2959@1|root,COG2959@2|Bacteria,2I2HI@201174|Actinobacteria,4CV8Q@84998|Coriobacteriia	84998|Coriobacteriia	H	Protein of unknown function (DUF4012)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4012
k59_1285640_1	351746.Pput_3558	2.33e-58	189.0	COG2071@1|root,COG2071@2|Bacteria,1MV8E@1224|Proteobacteria,1RS51@1236|Gammaproteobacteria,1YV1Z@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	PFAM Peptidase C26	spuA	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
k59_454080_1	395493.BegalDRAFT_2459	1.83e-57	201.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,45ZPW@72273|Thiotrichales	72273|Thiotrichales	P	heavy metal translocating P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_1285649_1	565045.NOR51B_72	4.46e-60	202.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1RQJX@1236|Gammaproteobacteria,1J8RS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	Q	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
k59_337586_1	232721.Ajs_2730	1.12e-43	149.0	COG3415@1|root,COG3415@2|Bacteria,1NJZ0@1224|Proteobacteria,2VYH8@28216|Betaproteobacteria,4AIM7@80864|Comamonadaceae	28216|Betaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_33
k59_337595_1	1286106.MPL1_01388	4.49e-63	197.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,460EK@72273|Thiotrichales	72273|Thiotrichales	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_337595_2	1111732.AZOD01000007_gene451	1.33e-19	85.9	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1X4J2@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_512872_1	1123355.JHYO01000001_gene3226	8.48e-41	151.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N,Transketolase_C
k59_1217887_1	525897.Dbac_3234	1.44e-50	163.0	COG2236@1|root,COG2236@2|Bacteria,1MWNE@1224|Proteobacteria,42RSU@68525|delta/epsilon subdivisions,2WMYZ@28221|Deltaproteobacteria,2MB60@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Acts on guanine, xanthine and to a lesser extent hypoxanthine	gpt	-	2.4.2.22	ko:K00769	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_1217887_2	1121406.JAEX01000007_gene2403	7.49e-84	264.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,42NTY@68525|delta/epsilon subdivisions,2WK4F@28221|Deltaproteobacteria,2M8EW@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM ABC transporter related	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
k59_1745860_1	1043205.AFYF01000065_gene2185	3.37e-39	135.0	COG2110@1|root,COG2110@2|Bacteria,2IFEC@201174|Actinobacteria,4FGQM@85021|Intrasporangiaceae	201174|Actinobacteria	S	phosphatase homologous to the C-terminal domain of histone macroH2A1	lppD	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Macro
k59_865302_1	1120983.KB894576_gene3474	3.93e-36	130.0	COG0730@1|root,COG0730@2|Bacteria,1PJR4@1224|Proteobacteria,2TU14@28211|Alphaproteobacteria,1JQE9@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_1037256_1	933262.AXAM01000025_gene3411	1.75e-74	233.0	COG3481@1|root,COG3481@2|Bacteria,1NH0C@1224|Proteobacteria,42Q7X@68525|delta/epsilon subdivisions,2WJW2@28221|Deltaproteobacteria,2MICY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	nucleic acid binding OB-fold tRNA helicase-type	yhaM	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
k59_1568946_1	446469.Sked_23270	1.49e-67	233.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria	201174|Actinobacteria	D	Belongs to the FtsK SpoIIIE SftA family	ftsK	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1800727_1	1122135.KB893134_gene3651	1.37e-07	52.8	COG3474@1|root,COG3474@2|Bacteria,1RIDN@1224|Proteobacteria,2U142@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	cytochrome	cycM	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
k59_1393013_1	1304865.JAGF01000001_gene778	5.18e-101	302.0	COG0560@1|root,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,4F0KZ@85016|Cellulomonadaceae	201174|Actinobacteria	E	TIGRFAM HAD-superfamily subfamily IB hydrolase, TIGR01490	serB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	HAD
k59_1393013_2	446466.Cfla_2808	1.33e-160	466.0	COG2271@1|root,COG2271@2|Bacteria,2GK3N@201174|Actinobacteria	201174|Actinobacteria	G	Major facilitator superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
k59_748314_1	670307.HYPDE_33613	2.69e-80	253.0	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,2TS8J@28211|Alphaproteobacteria,3N6T0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF559,SpoU_methylase
k59_1110865_1	926560.KE387023_gene3658	1.02e-35	132.0	COG0500@1|root,COG2226@2|Bacteria,1WMEJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1226195_1	991905.SL003B_1214	1.67e-70	232.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2TT32@28211|Alphaproteobacteria,4BPGY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_169492_1	1123504.JQKD01000011_gene2348	8.68e-20	89.7	2CCFR@1|root,2Z7VF@2|Bacteria,1MXHU@1224|Proteobacteria,2VHMR@28216|Betaproteobacteria,4A9VF@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1696497_2	314264.ROS217_12641	6.26e-95	283.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2TSYJ@28211|Alphaproteobacteria,46QPE@74030|Roseovarius	28211|Alphaproteobacteria	P	COG4149 ABC-type molybdate transport system, permease component	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
k59_1752638_1	1219375.CM002139_gene1226	6.41e-28	107.0	COG0745@1|root,COG0745@2|Bacteria,1RA00@1224|Proteobacteria,1S23N@1236|Gammaproteobacteria,1X3BY@135614|Xanthomonadales	135614|Xanthomonadales	K	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_1752638_2	1469245.JFBG01000033_gene1414	1.24e-47	168.0	COG0642@1|root,COG0642@2|Bacteria,1R54G@1224|Proteobacteria,1RWXF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	colS	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_1226218_1	583355.Caka_1699	2.19e-32	130.0	COG5361@1|root,COG5361@2|Bacteria	2|Bacteria	P	Conserved Protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1577710_1	1120949.KB903294_gene4505	1.6e-18	84.7	COG2072@1|root,COG2072@2|Bacteria,2GM3S@201174|Actinobacteria,4D9DG@85008|Micromonosporales	201174|Actinobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
k59_636899_1	384765.SIAM614_11493	4.4e-77	239.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	MA20_32190	-	3.6.3.31	ko:K02052,ko:K11072	ko02010,ko02024,map02010,map02024	M00193,M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11,3.A.1.11.1	-	-	ABC_tran,TOBE_2
k59_1047180_1	713587.THITH_16360	5.33e-47	161.0	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0501 Zn-dependent protease with chaperone function	Z012_09445	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_1577724_1	933262.AXAM01000048_gene2576	2.13e-47	169.0	COG0457@1|root,COG1944@1|root,COG0457@2|Bacteria,COG1944@2|Bacteria,1MV7K@1224|Proteobacteria,42N4B@68525|delta/epsilon subdivisions,2WJ34@28221|Deltaproteobacteria,2MHRU@213118|Desulfobacterales	28221|Deltaproteobacteria	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8,YcaO
k59_227519_2	1502851.FG93_06077	6.47e-46	158.0	COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,2U874@28211|Alphaproteobacteria,3JRK1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2
k59_804986_2	9544.ENSMMUP00000032251	5.65e-56	185.0	COG0596@1|root,KOG4178@2759|Eukaryota,39VYC@33154|Opisthokonta,3BNBY@33208|Metazoa,3CT56@33213|Bilateria,48GUN@7711|Chordata	33208|Metazoa	I	Alpha/beta hydrolase family	-	-	1.13.12.5	ko:K18053	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
k59_1577733_1	1333998.M2A_2804	9.05e-41	155.0	COG0642@1|root,COG2205@2|Bacteria,1MVY8@1224|Proteobacteria,2TS5B@28211|Alphaproteobacteria,4BPC4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	PAS fold	divL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,PAS_8
k59_696845_2	1156935.QWE_09411	2.56e-37	138.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TRX9@28211|Alphaproteobacteria,4BCH4@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	MA20_09805	-	-	-	-	-	-	-	-	-	-	-	DAO
k59_344969_1	1120950.KB892708_gene4261	2.53e-10	59.7	COG0537@1|root,COG0537@2|Bacteria,2IHPT@201174|Actinobacteria,4DRZV@85009|Propionibacteriales	201174|Actinobacteria	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
k59_1752675_1	420662.Mpe_A2580	1.48e-28	113.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2VKIS@28216|Betaproteobacteria,1KIVX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3734,Patatin,Pyr_redox_2,Reductase_C
k59_1752675_2	395493.BegalDRAFT_3412	4.01e-42	152.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,1RSCT@1236|Gammaproteobacteria,4624S@72273|Thiotrichales	72273|Thiotrichales	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_460727_1	1713.JOFV01000004_gene3488	3.99e-86	264.0	COG1120@1|root,COG1120@2|Bacteria,2GN5T@201174|Actinobacteria,4F135@85016|Cellulomonadaceae	201174|Actinobacteria	HP	PFAM ABC transporter related	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_227553_1	1108045.GORHZ_171_00530	4.59e-15	68.9	COG4691@1|root,COG4691@2|Bacteria,2GSHN@201174|Actinobacteria	201174|Actinobacteria	S	Plasmid stability protein	-	-	-	ko:K21495	-	-	-	-	ko00000,ko02048	-	-	-	Arc
k59_227553_2	1121019.AUMN01000003_gene1021	1.52e-68	210.0	COG1487@1|root,COG1487@2|Bacteria,2IS29@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07062	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
k59_1635813_1	1168289.AJKI01000053_gene807	1.18e-90	280.0	COG0502@1|root,COG0502@2|Bacteria,4NEI7@976|Bacteroidetes,2FM8N@200643|Bacteroidia,3XIP7@558415|Marinilabiliaceae	976|Bacteroidetes	H	Biotin and Thiamin Synthesis associated domain	hydG	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
k59_696872_1	555778.Hneap_1263	4.32e-64	205.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1WXEN@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_696872_2	637905.SVI_3412	3.47e-55	179.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,2Q938@267890|Shewanellaceae	1236|Gammaproteobacteria	J	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048519,GO:0050789,GO:0051186,GO:0051188,GO:0051604,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	iECSF_1327.ECSF_0569,iSFV_1184.SFV_0696,iSFxv_1172.SFxv_0718	BPL_LplA_LipB
k59_1577793_1	471853.Bcav_1766	3.3e-96	286.0	COG1381@1|root,COG1381@2|Bacteria,2GK81@201174|Actinobacteria	201174|Actinobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
k59_698504_1	323261.Noc_0810	5.47e-97	288.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1WX9S@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_1162127_2	1267533.KB906734_gene3937	1.51e-31	114.0	COG1504@1|root,COG1504@2|Bacteria	2|Bacteria	L	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
k59_579544_1	396588.Tgr7_0666	3.73e-65	207.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45,3.1.1.76	ko:K01061,ko:K22249	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_876536_1	1267535.KB906767_gene1214	1.34e-70	229.0	COG2433@1|root,COG2433@2|Bacteria,3Y7F1@57723|Acidobacteria	57723|Acidobacteria	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
k59_462234_1	323261.Noc_1168	7.22e-17	75.9	2AFCJ@1|root,315C6@2|Bacteria,1RH66@1224|Proteobacteria,1S9MI@1236|Gammaproteobacteria,1WYGK@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF1841)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1841
k59_1228259_2	631362.Thi970DRAFT_04503	1e-11	63.9	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1X0NZ@135613|Chromatiales	135613|Chromatiales	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1754230_1	1232437.KL662015_gene1289	6.15e-71	224.0	COG3039@1|root,COG3039@2|Bacteria,1R6NB@1224|Proteobacteria,42RBZ@68525|delta/epsilon subdivisions,2WMWZ@28221|Deltaproteobacteria,2MQ2G@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_876542_1	1385935.N836_00970	9.69e-32	126.0	COG0534@1|root,COG0534@2|Bacteria	2|Bacteria	V	drug transmembrane transporter activity	norM-2	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
k59_1049544_1	1121405.dsmv_2921	1.24e-43	161.0	COG0493@1|root,COG2878@1|root,COG0493@2|Bacteria,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,42MPF@68525|delta/epsilon subdivisions,2X5BJ@28221|Deltaproteobacteria,2MISB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Putative Fe-S cluster	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fer4,Fer4_20,Fer4_9,Pyr_redox_2
k59_1228268_1	883078.HMPREF9695_02768	1.44e-60	197.0	COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,2TR16@28211|Alphaproteobacteria,3JUPA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	mandelate racemase muconate lactonizing	ycjG	GO:0003674,GO:0003824,GO:0016853,GO:0016854,GO:0016855	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_1049565_1	1047013.AQSP01000135_gene1565	1.43e-51	177.0	COG0304@1|root,COG0304@2|Bacteria,2NNSX@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179,2.3.1.41	ko:K00647,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1637490_1	765911.Thivi_1085	6.37e-06	52.4	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1WWK5@135613|Chromatiales	135613|Chromatiales	O	FeS assembly protein SufD	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_1637490_2	595460.RRSWK_02470	2.01e-05	45.8	COG0396@1|root,COG0396@2|Bacteria,2IY5X@203682|Planctomycetes	203682|Planctomycetes	O	COG0396 ABC-type transport system involved in Fe-S cluster assembly ATPase component	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
k59_1228274_1	1294143.H681_07900	2.7e-82	251.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_2444	PALP
k59_1698531_1	1185652.USDA257_c11870	2.03e-31	125.0	COG2114@1|root,COG4192@1|root,COG2114@2|Bacteria,COG4192@2|Bacteria,1MV1V@1224|Proteobacteria,2U2BQ@28211|Alphaproteobacteria,4BN8Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	PAS fold	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP,PAS_7
k59_579570_1	631362.Thi970DRAFT_01121	3.84e-82	254.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,1WXTC@135613|Chromatiales	135613|Chromatiales	L	transposase IS116 IS110 IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_638487_1	446469.Sked_18160	3.45e-17	82.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2GIWJ@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribA	-	3.5.4.25,4.1.99.12	ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2,Lum_binding
k59_638487_2	494419.ALPM01000054_gene2807	7.93e-47	160.0	COG0307@1|root,COG0307@2|Bacteria,2GKC5@201174|Actinobacteria,1W90N@1268|Micrococcaceae	201174|Actinobacteria	H	riboflavin synthase, alpha subunit	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
k59_171506_1	768671.ThimaDRAFT_2202	5.85e-60	199.0	COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,1RRFT@1236|Gammaproteobacteria,1WY2W@135613|Chromatiales	135613|Chromatiales	L	COG3385 FOG Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_876593_1	1004785.AMBLS11_16295	4.69e-08	58.5	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	2.4.1.268	ko:K20444,ko:K21349	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4,GT81	-	Glycos_transf_2
k59_1228303_1	316273.XCV0018	3.83e-79	247.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,1RQNF@1236|Gammaproteobacteria,1X3K1@135614|Xanthomonadales	135614|Xanthomonadales	L	DNA repair photolyase	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_758470_1	1304865.JAGF01000001_gene3278	3.43e-270	761.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,2H7WY@201174|Actinobacteria,4F10M@85016|Cellulomonadaceae	201174|Actinobacteria	P	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	cdr	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
k59_346724_2	1440053.JOEI01000016_gene1015	5e-35	133.0	28IHG@1|root,2Z8IP@2|Bacteria,2ID5Q@201174|Actinobacteria	201174|Actinobacteria	S	Helicase conserved C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_3
k59_1462740_1	452637.Oter_2925	5.1e-117	360.0	COG1874@1|root,COG1874@2|Bacteria,46YTQ@74201|Verrucomicrobia,3K9MX@414999|Opitutae	414999|Opitutae	G	Glycosyl hydrolases family 35	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_35
k59_1162200_1	999541.bgla_2g29680	5.24e-25	109.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2VP0K@28216|Betaproteobacteria,1KD2N@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,Response_reg
k59_1698583_1	420324.KI912075_gene8394	8.82e-30	119.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2TW3U@28211|Alphaproteobacteria,1JZHH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_229431_1	367299.JOEE01000001_gene2107	4.93e-102	330.0	COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria,2GIZP@201174|Actinobacteria,4FESC@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acetyl-CoA carboxylase, central region	-	-	-	-	-	-	-	-	-	-	-	-	ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
k59_698615_1	1463900.JOIX01000136_gene1860	6.39e-17	80.9	COG1396@1|root,COG1396@2|Bacteria,2IAUW@201174|Actinobacteria	201174|Actinobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
k59_171558_1	1200352.A606_10815	9.35e-50	181.0	COG0455@1|root,COG1835@1|root,COG2755@1|root,COG0455@2|Bacteria,COG1835@2|Bacteria,COG2755@2|Bacteria,2GKI5@201174|Actinobacteria,22JW6@1653|Corynebacteriaceae	201174|Actinobacteria	I	acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3,Lipase_GDSL_2
k59_462315_2	745014.OMB55_00000690	4.73e-84	265.0	COG1196@1|root,COG1196@2|Bacteria,1R4BS@1224|Proteobacteria,1S13B@1236|Gammaproteobacteria,1J7UD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	von Willebrand factor (VWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_346764_1	1049564.TevJSym_bh00170	2.3e-95	286.0	COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,1RMKF@1236|Gammaproteobacteria,1J5A8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the peptidase S33 family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
k59_1579990_1	713587.THITH_10600	7.2e-69	228.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales	135613|Chromatiales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	-	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1637561_1	396588.Tgr7_1464	4.9e-104	313.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,1WWK8@135613|Chromatiales	135613|Chromatiales	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
k59_806625_1	446469.Sked_26430	4.7e-132	389.0	COG1570@1|root,COG1570@2|Bacteria,2GJAS@201174|Actinobacteria	201174|Actinobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_1580009_1	367299.JOEE01000001_gene1980	6.2e-143	422.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4FECS@85021|Intrasporangiaceae	201174|Actinobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_229473_1	471853.Bcav_3970	1.74e-16	74.3	COG1950@1|root,COG1950@2|Bacteria,2IHP5@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
k59_229473_2	471853.Bcav_3971	2.49e-28	115.0	COG0596@1|root,COG0596@2|Bacteria,2I6JQ@201174|Actinobacteria	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_758545_1	1121935.AQXX01000132_gene2674	4.01e-66	216.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,1RNUS@1236|Gammaproteobacteria,1XI5H@135619|Oceanospirillales	135619|Oceanospirillales	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_1403436_1	1123354.AUDR01000013_gene516	1.35e-111	335.0	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,2VHSF@28216|Betaproteobacteria,1KS6X@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Cytochrome D1 heme domain	-	-	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_876689_1	446466.Cfla_1004	1.46e-49	174.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4F0PP@85016|Cellulomonadaceae	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_1637576_1	1121921.KB898707_gene1068	3.86e-41	143.0	2C852@1|root,32YB2@2|Bacteria,1RH28@1224|Proteobacteria,1T179@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
k59_1049744_1	644282.Deba_1057	8.01e-34	120.0	COG0745@1|root,COG0745@2|Bacteria,1N3R6@1224|Proteobacteria,42TU3@68525|delta/epsilon subdivisions,2WQ9W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_462349_1	2340.JV46_24910	7.97e-66	209.0	COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,1RP5A@1236|Gammaproteobacteria,1J5ZG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase	cysQ	GO:0000103,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	iAPECO1_1312.APECO1_2172,iE2348C_1286.E2348C_4545,iEC042_1314.EC042_4695,iEC55989_1330.EC55989_4774,iECABU_c1320.ECABU_c47840,iECIAI1_1343.ECIAI1_4448,iECIAI39_1322.ECIAI39_4686,iECO103_1326.ECO103_5013,iECO111_1330.ECO111_5101,iECO26_1355.ECO26_5384,iECOK1_1307.ECOK1_4735,iECP_1309.ECP_4468,iECSE_1348.ECSE_4520,iECSF_1327.ECSF_4108,iECUMN_1333.ECUMN_4751,iECW_1372.ECW_m4578,iEKO11_1354.EKO11_4094,iEcE24377_1341.EcE24377A_4785,iEcHS_1320.EcHS_A4468,iEcSMS35_1347.EcSMS35_4694,iLF82_1304.LF82_0422,iNRG857_1313.NRG857_21455,iSBO_1134.SBO_4229,iSDY_1059.SDY_4385,iSSON_1240.SSON_4399,iSbBS512_1146.SbBS512_E4758,iUMN146_1321.UM146_21355,iUTI89_1310.UTI89_C4823,iWFL_1372.ECW_m4578,ic_1306.c5313	Inositol_P
k59_1049757_1	765912.Thimo_3268	1.93e-142	410.0	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,1RQBE@1236|Gammaproteobacteria,1WX20@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
k59_638586_2	710696.Intca_0926	2.59e-26	103.0	COG1825@1|root,COG1825@2|Bacteria,2GJPJ@201174|Actinobacteria,4FE4J@85021|Intrasporangiaceae	201174|Actinobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_1754364_1	631362.Thi970DRAFT_03609	3.09e-59	197.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1WWK3@135613|Chromatiales	135613|Chromatiales	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_1162286_1	706587.Desti_3270	6.9e-62	215.0	COG2202@1|root,COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_638592_1	1380356.JNIK01000013_gene4246	9.87e-44	153.0	COG0496@1|root,COG0496@2|Bacteria,2IRBR@201174|Actinobacteria,4EVR8@85013|Frankiales	201174|Actinobacteria	S	Survival protein SurE	-	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
k59_229499_1	765914.ThisiDRAFT_0188	3.4e-55	183.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1WWTF@135613|Chromatiales	135613|Chromatiales	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
k59_588855_1	870187.Thini_4262	4.9e-12	65.5	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_588855_2	998674.ATTE01000001_gene1294	9.35e-34	123.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,462E8@72273|Thiotrichales	72273|Thiotrichales	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1469387_1	472759.Nhal_2085	3.5e-65	212.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,1WVWN@135613|Chromatiales	135613|Chromatiales	M	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N
k59_1822639_1	933262.AXAM01000009_gene1481	1.6e-93	283.0	28MQN@1|root,2ZAZG@2|Bacteria,1MVVQ@1224|Proteobacteria,42MMM@68525|delta/epsilon subdivisions,2WKA1@28221|Deltaproteobacteria,2MHKP@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_883464_2	768671.ThimaDRAFT_1715	4.05e-98	291.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,1WWC1@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM FeS assembly ATPase SufC	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
k59_1058691_1	420247.Msm_0300	0.000332	48.9	COG0747@1|root,arCOG01534@2157|Archaea,2XVIU@28890|Euryarchaeota,23PAD@183925|Methanobacteria	183925|Methanobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_588859_1	1183438.GKIL_2767	0.000998	43.1	COG0758@1|root,COG0758@2|Bacteria,1GACU@1117|Cyanobacteria	1117|Cyanobacteria	LU	Putative molybdenum carrier	-	-	-	-	-	-	-	-	-	-	-	-	MoCo_carrier
k59_355037_1	620914.JH621275_gene390	1.64e-69	225.0	COG0154@1|root,COG0154@2|Bacteria,4NF8C@976|Bacteroidetes,1HXBS@117743|Flavobacteriia,2YJ7T@290174|Aquimarina	976|Bacteroidetes	J	Amidase	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_1410657_1	933262.AXAM01000004_gene2364	4.77e-96	293.0	COG0438@1|root,COG0438@2|Bacteria,1R8YI@1224|Proteobacteria,42N8I@68525|delta/epsilon subdivisions,2WIYJ@28221|Deltaproteobacteria,2MMJB@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
k59_61603_2	1049564.TevJSym_ac01740	1.62e-62	218.0	28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria,1S1M3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
k59_1822654_1	765911.Thivi_0907	3.98e-71	221.0	2CDCV@1|root,308Y1@2|Bacteria,1N74F@1224|Proteobacteria,1S130@1236|Gammaproteobacteria,1WWVV@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_236900_1	367299.JOEE01000001_gene1768	2.76e-63	218.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,2GKG6@201174|Actinobacteria,4FE6H@85021|Intrasporangiaceae	201174|Actinobacteria	F	involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
k59_1762807_1	472759.Nhal_1481	2e-229	641.0	COG2403@1|root,COG2403@2|Bacteria,1MV4C@1224|Proteobacteria	1224|Proteobacteria	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_647568_1	536233.CLO_0896	8.84e-18	88.6	COG1196@1|root,COG5283@1|root,COG5412@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,COG5412@2|Bacteria,1TQ28@1239|Firmicutes,247QT@186801|Clostridia,36E7F@31979|Clostridiaceae	186801|Clostridia	M	tail tape measure protein	-	-	-	-	-	-	-	-	-	-	-	-	PhageMin_Tail
k59_1586611_2	398767.Glov_0977	1.1e-42	155.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2WIKU@28221|Deltaproteobacteria,43TN4@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1,7-bisphosphate	hldE	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_0922	CTP_transf_like,PfkB
k59_823559_1	243231.GSU0567	2.68e-44	148.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,42QWV@68525|delta/epsilon subdivisions,2WMPT@28221|Deltaproteobacteria,43SFH@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
k59_823559_2	626887.J057_07381	1.89e-31	117.0	COG1226@1|root,31669@2|Bacteria,1RIW0@1224|Proteobacteria,1S6HC@1236|Gammaproteobacteria,4688E@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Ion transport 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
k59_823559_3	290397.Adeh_2106	7.18e-81	249.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,42NCJ@68525|delta/epsilon subdivisions,2WM7V@28221|Deltaproteobacteria,2Z1U0@29|Myxococcales	28221|Deltaproteobacteria	P	Dimerisation domain of Zinc Transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_1410664_1	1049564.TevJSym_bf00220	4.46e-42	149.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria,1J707@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Metal dependent phosphohydrolases with conserved 'HD' motif.	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_1410664_2	1158165.KB898873_gene652	5.11e-29	113.0	28TTJ@1|root,2ZG0P@2|Bacteria,1RCSB@1224|Proteobacteria,1S3B4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1645699_1	765913.ThidrDRAFT_3821	1.84e-101	308.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1WWAI@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,Pribosyltran
k59_706285_1	36809.MAB_3073	2.31e-46	156.0	COG2128@1|root,COG2128@2|Bacteria,2IAD2@201174|Actinobacteria,23864@1762|Mycobacteriaceae	201174|Actinobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_1469412_1	1122622.ATWJ01000010_gene1267	1.81e-10	60.1	COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4FFKZ@85021|Intrasporangiaceae	201174|Actinobacteria	S	Carboxylate--amine ligase	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
k59_1469412_2	367299.JOEE01000008_gene628	1.41e-122	353.0	COG0637@1|root,COG0637@2|Bacteria,2GJNG@201174|Actinobacteria,4FF3W@85021|Intrasporangiaceae	201174|Actinobacteria	S	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_1469412_3	367299.JOEE01000008_gene627	2.2e-75	231.0	COG2887@1|root,COG2887@2|Bacteria,2GJC5@201174|Actinobacteria,4FFDN@85021|Intrasporangiaceae	201174|Actinobacteria	L	Domain of unknown function DUF83	recB	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	PDDEXK_1
k59_471428_1	243233.MCA1253	3.57e-169	497.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1XDJY@135618|Methylococcales	135618|Methylococcales	E	Peptidase family M3	prlC	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_883500_1	543632.JOJL01000005_gene4758	2.27e-38	148.0	COG0515@1|root,COG2199@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,2IBPU@201174|Actinobacteria,4DAU6@85008|Micromonosporales	201174|Actinobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF_2,GGDEF,Pkinase
k59_1469414_1	1177179.A11A3_13555	1.69e-42	148.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,1XH47@135619|Oceanospirillales	135619|Oceanospirillales	IQ	reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_412677_1	1535422.ND16A_2165	4.13e-40	150.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,2Q5X4@267889|Colwelliaceae	1236|Gammaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_942236_2	1454004.AW11_03116	2.56e-111	328.0	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,2VHYC@28216|Betaproteobacteria,1KQVC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	potH	-	-	ko:K11071,ko:K11075	ko02010,map02010	M00299,M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1,3.A.1.11.2	-	-	BPD_transp_1
k59_1294410_1	768671.ThimaDRAFT_1370	5.01e-128	373.0	COG2143@1|root,COG2143@2|Bacteria,1R72D@1224|Proteobacteria,1RSDK@1236|Gammaproteobacteria,1WVUU@135613|Chromatiales	135613|Chromatiales	O	Thioredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
k59_412679_2	2340.JV46_21830	2.21e-29	111.0	2DP15@1|root,3303T@2|Bacteria,1N7NN@1224|Proteobacteria,1S90P@1236|Gammaproteobacteria,1J6SN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4426)	PP5099	-	-	-	-	-	-	-	-	-	-	-	DUF4426
k59_296362_1	1283300.ATXB01000001_gene2037	1.53e-43	157.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1XDXK@135618|Methylococcales	135618|Methylococcales	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,LysM
k59_1000513_1	1184609.KILIM_052_00160	8.26e-07	50.4	COG1622@1|root,COG1622@2|Bacteria,2GNXA@201174|Actinobacteria,4F64V@85018|Dermatophilaceae	201174|Actinobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	ctaC	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
k59_1000513_2	367299.JOEE01000004_gene1434	4.27e-82	259.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4FF4D@85021|Intrasporangiaceae	201174|Actinobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0040007,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_1235617_1	1265313.HRUBRA_00929	8.75e-51	175.0	COG1196@1|root,COG1196@2|Bacteria,1R4BS@1224|Proteobacteria,1S13B@1236|Gammaproteobacteria,1J7UD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	von Willebrand factor (VWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_707325_1	1121937.AUHJ01000005_gene2319	2.43e-63	200.0	COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,466DN@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
k59_707325_2	1122603.ATVI01000005_gene3300	3.79e-07	50.4	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1X4C5@135614|Xanthomonadales	135614|Xanthomonadales	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1763728_1	710696.Intca_0913	9.72e-46	167.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4FG4H@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Multicopper oxidase	-	-	1.3.3.5	ko:K08100	ko00860,ko01110,map00860,map01110	-	R02394	RC01983	ko00000,ko00001,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_943609_1	713587.THITH_16600	5.08e-31	121.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,1RQJQ@1236|Gammaproteobacteria,1WYZZ@135613|Chromatiales	135613|Chromatiales	I	PFAM Fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_1059784_1	456442.Mboo_0117	2.4e-87	266.0	COG0391@1|root,arCOG04395@2157|Archaea,2XTPP@28890|Euryarchaeota,2N94E@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP	cofD	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
k59_531194_2	457570.Nther_1166	1.85e-30	119.0	COG3804@1|root,COG3804@2|Bacteria,1TRNF@1239|Firmicutes,249AS@186801|Clostridia	186801|Clostridia	S	dihydrodipicolinate reductase	-	-	1.4.1.12,1.4.1.26	ko:K21672	ko00310,ko00330,ko00472,map00310,map00330,map00472	-	R02825,R04200,R04201,R04687,R04688	RC00249,RC00790	ko00000,ko00001,ko01000	-	-	-	DapB_N
k59_296375_1	1385521.N803_04135	1.1e-71	232.0	COG2252@1|root,COG2252@2|Bacteria,2GKYD@201174|Actinobacteria,4FE4H@85021|Intrasporangiaceae	201174|Actinobacteria	S	permease	pbuG	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
k59_63023_1	768671.ThimaDRAFT_4175	1.33e-67	227.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1WXPW@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
k59_1176907_1	1435356.Y013_12735	7.55e-125	369.0	COG2508@1|root,COG2508@2|Bacteria,2GP8S@201174|Actinobacteria,4G4FN@85025|Nocardiaceae	201174|Actinobacteria	QT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
k59_178885_1	765912.Thimo_2736	5.43e-85	261.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1WWB3@135613|Chromatiales	135613|Chromatiales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_120267_1	1449347.JQLN01000005_gene5541	6.91e-76	234.0	COG1131@1|root,COG1131@2|Bacteria,2I2I7@201174|Actinobacteria,2M22M@2063|Kitasatospora	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_120267_2	1123320.KB889585_gene1844	1.74e-32	120.0	COG0842@1|root,COG0842@2|Bacteria,2GJ7Y@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K01990,ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_1411686_1	472759.Nhal_3454	1.74e-29	113.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1WY2F@135613|Chromatiales	135613|Chromatiales	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_1117927_1	1304865.JAGF01000001_gene2635	8.83e-38	138.0	COG0365@1|root,COG0365@2|Bacteria,2I2IW@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
k59_63038_1	710696.Intca_0451	2.98e-86	276.0	COG1501@1|root,COG1501@2|Bacteria,2GP4V@201174|Actinobacteria,4FG4A@85021|Intrasporangiaceae	201174|Actinobacteria	G	Glycosyl hydrolases family 31	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
k59_884914_1	765914.ThisiDRAFT_1778	6.61e-86	275.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1WX4B@135613|Chromatiales	135613|Chromatiales	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_765643_1	1232683.ADIMK_3516	8.46e-64	200.0	COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,1S425@1236|Gammaproteobacteria,46CS4@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Glutathione peroxidase	btuE	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
k59_237975_2	1380354.JIAN01000005_gene1570	2e-20	87.8	2EGB2@1|root,33A2X@2|Bacteria,2HXXD@201174|Actinobacteria,4F1IE@85016|Cellulomonadaceae	201174|Actinobacteria	S	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
k59_1117928_1	1115803.HMPREF1129_2090	1.99e-12	70.1	2CT9V@1|root,32SSX@2|Bacteria,2GKR6@201174|Actinobacteria,4D59N@85005|Actinomycetales	201174|Actinobacteria	S	Domain of unknown function (DUF4129)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
k59_1117928_2	1380354.JIAN01000006_gene1114	4.62e-14	76.3	29B69@1|root,2ZY4N@2|Bacteria,2GKQW@201174|Actinobacteria,4F1XW@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF4350
k59_1411703_1	1038869.AXAN01000247_gene2193	6.7e-95	285.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW8A@1224|Proteobacteria,2VPNY@28216|Betaproteobacteria,1K7N5@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_32,HTH_33
k59_63049_1	1306174.JODP01000001_gene5102	1.85e-86	291.0	COG1330@1|root,COG1330@2|Bacteria,2GNVB@201174|Actinobacteria	201174|Actinobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity	recC	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
k59_884936_1	1123377.AUIV01000007_gene1241	5.7e-80	264.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X41A@135614|Xanthomonadales	135614|Xanthomonadales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_413585_1	335543.Sfum_3133	1.18e-81	268.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MQVU@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_296410_1	188626.HMPREF0321_0329	8.9e-90	272.0	COG1414@1|root,COG1414@2|Bacteria,2GKB0@201174|Actinobacteria,1ZWDX@145357|Dermacoccaceae	201174|Actinobacteria	K	helix_turn_helix isocitrate lyase regulation	ltbR	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_63061_2	1283300.ATXB01000002_gene3073	8.76e-115	352.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1XEFK@135618|Methylococcales	135618|Methylococcales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_1176941_2	86416.Clopa_2023	3.22e-47	155.0	COG0432@1|root,COG0432@2|Bacteria,1V6J7@1239|Firmicutes,24J8G@186801|Clostridia,36IYZ@31979|Clostridiaceae	186801|Clostridia	S	Secondary thiamine-phosphate synthase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
k59_1824077_1	1265502.KB905941_gene2933	6.51e-74	247.0	COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,1NZZ9@1224|Proteobacteria,2VRRA@28216|Betaproteobacteria	28216|Betaproteobacteria	N	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_356567_1	1267005.KB911257_gene1051	3.38e-74	232.0	2EY8I@1|root,33RH3@2|Bacteria,1NS5H@1224|Proteobacteria,2UP0R@28211|Alphaproteobacteria,3N86N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1824080_1	1220535.IMCC14465_09500	2.82e-37	139.0	COG4638@1|root,COG4638@2|Bacteria,1R83A@1224|Proteobacteria,2U4UP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
k59_707367_1	205918.Psyr_3185	7.65e-20	81.6	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1Z83G@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	K	Cold shock protein domain	cspD	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006275,GO:0006355,GO:0006950,GO:0008150,GO:0008156,GO:0009266,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031667,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2000113,GO:2001141	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_707367_2	768671.ThimaDRAFT_2426	3.05e-55	174.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,1S8Z7@1236|Gammaproteobacteria,1WYBV@135613|Chromatiales	135613|Chromatiales	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
k59_707367_3	765913.ThidrDRAFT_0306	2.11e-129	390.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1WWT9@135613|Chromatiales	135613|Chromatiales	O	Belongs to the ClpA ClpB family	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1705269_1	1033802.SSPSH_002352	3.39e-110	338.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1587553_1	1415780.JPOG01000001_gene1614	1.03e-34	128.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria,1X36W@135614|Xanthomonadales	135614|Xanthomonadales	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
k59_648584_1	367299.JOEE01000002_gene2399	6.56e-52	174.0	COG0079@1|root,COG0079@2|Bacteria,2GJXS@201174|Actinobacteria,4FEZ6@85021|Intrasporangiaceae	201174|Actinobacteria	E	May catalyze the transamination reaction in phenylalanine biosynthesis	pat	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_648584_2	1184609.KILIM_054_00090	1.87e-20	85.9	COG1950@1|root,COG1950@2|Bacteria,2IHP5@201174|Actinobacteria,4F863@85018|Dermatophilaceae	201174|Actinobacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
k59_1235698_1	2340.JV46_08720	4.64e-69	229.0	COG0589@1|root,COG0730@1|root,COG0589@2|Bacteria,COG0730@2|Bacteria,1NBKV@1224|Proteobacteria,1SHMY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Universal stress protein family	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE,Usp
k59_1295939_1	765914.ThisiDRAFT_0270	2.45e-99	303.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1WW6C@135613|Chromatiales	135613|Chromatiales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_1705298_1	1123371.ATXH01000023_gene933	1.85e-45	166.0	COG1614@1|root,COG1614@2|Bacteria,2GHDC@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	CO dehydrogenase/acetyl-CoA synthase complex beta subunit	-	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
k59_63124_1	1049564.TevJSym_ad00310	3.16e-48	167.0	2E6HP@1|root,3314Y@2|Bacteria,1QGPJ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_893826_2	882378.RBRH_03189	8.25e-59	194.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,2VJS2@28216|Betaproteobacteria,1K1P3@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
k59_893826_3	1397527.Q670_03930	2.63e-22	93.6	COG0835@1|root,COG0835@2|Bacteria,1NA8G@1224|Proteobacteria,1SCB2@1236|Gammaproteobacteria,1XMEB@135619|Oceanospirillales	135619|Oceanospirillales	NT	CheW-like domain	-	-	-	ko:K06598	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
k59_1359146_1	1283299.AUKG01000001_gene2516	2.04e-32	127.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,2GK62@201174|Actinobacteria,4CR6R@84995|Rubrobacteria	84995|Rubrobacteria	OT	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Response_reg
k59_248875_1	1411123.JQNH01000001_gene2581	2.26e-62	217.0	COG0591@1|root,COG0642@1|root,COG0784@1|root,COG0591@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	MA20_19630	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
k59_1711201_1	709032.Sulku_1049	3.69e-39	149.0	COG3829@1|root,COG5001@1|root,COG3829@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2YMHP@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9
k59_72154_1	1184607.AUCHE_08_02850	8.9e-80	248.0	COG0533@1|root,COG0533@2|Bacteria,2GJ98@201174|Actinobacteria,4F606@85018|Dermatophilaceae	201174|Actinobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
k59_15196_1	998674.ATTE01000001_gene735	2.78e-105	322.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,463IR@72273|Thiotrichales	72273|Thiotrichales	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_302619_1	1038869.AXAN01000016_gene1418	2.64e-25	104.0	2E9FY@1|root,333P7@2|Bacteria,1N8S6@1224|Proteobacteria,2VWAN@28216|Betaproteobacteria,1K7R1@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1344
k59_1769656_1	1049564.TevJSym_ag00690	8.92e-81	261.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,1S0DI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	ko:K16886	-	-	-	-	ko00000	-	-	-	Fer4,FlpD,Pyr_redox_2
k59_1769656_2	1049564.TevJSym_ag00680	1.55e-31	120.0	COG1148@1|root,COG1148@2|Bacteria,1Q0ZF@1224|Proteobacteria,1RYIC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	FAD dependent oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388,ko:K16885	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Pyr_redox_2
k59_248885_1	1121921.KB898709_gene166	8.23e-21	91.7	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,2PN2H@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	E	Iron-containing alcohol dehydrogenase	aroB	GO:0000166,GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b3389,iBWG_1329.BWG_3080,iECDH10B_1368.ECDH10B_3564,iECDH1ME8569_1439.ECDH1ME8569_3268,iECNA114_1301.ECNA114_3486,iEcDH1_1363.EcDH1_0324,iJO1366.b3389,iJR904.b3389,iY75_1357.Y75_RS20275	DHQ_synthase
k59_248885_2	519989.ECTPHS_11822	1.15e-174	498.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria,1X0VD@135613|Chromatiales	135613|Chromatiales	F	Belongs to the dGTPase family. Type 2 subfamily	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_248885_3	1123073.KB899241_gene1922	1.06e-24	95.1	COG3831@1|root,COG3831@2|Bacteria,1NGUF@1224|Proteobacteria,1T6H3@1236|Gammaproteobacteria,1X7H4@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	WGR
k59_1243940_1	1121403.AUCV01000051_gene2131	1.23e-63	216.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42N78@68525|delta/epsilon subdivisions,2WM0M@28221|Deltaproteobacteria,2MHVS@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
k59_365637_1	382464.ABSI01000009_gene3930	7.91e-54	179.0	COG0667@1|root,COG0667@2|Bacteria,46SPV@74201|Verrucomicrobia,2ITQC@203494|Verrucomicrobiae	2|Bacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_365637_2	1216967.L100_00650	1.56e-44	157.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,4NE85@976|Bacteroidetes,1HY7H@117743|Flavobacteriia,34R6C@308865|Elizabethkingia	976|Bacteroidetes	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumB	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
k59_952871_2	458817.Shal_3240	1.03e-24	99.4	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,2Q938@267890|Shewanellaceae	1236|Gammaproteobacteria	J	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048519,GO:0050789,GO:0051186,GO:0051188,GO:0051604,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	iECSF_1327.ECSF_0569,iSFV_1184.SFV_0696,iSFxv_1172.SFxv_0718	BPL_LplA_LipB
k59_1305070_1	472759.Nhal_3283	3.37e-84	262.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RMVW@1236|Gammaproteobacteria,1WX6X@135613|Chromatiales	135613|Chromatiales	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_248896_1	436229.JOEH01000002_gene3340	1.73e-74	233.0	COG4152@1|root,COG4152@2|Bacteria,2I2DK@201174|Actinobacteria,2NF6B@228398|Streptacidiphilus	201174|Actinobacteria	S	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_1418620_1	1499967.BAYZ01000004_gene4922	4.12e-40	151.0	28M0D@1|root,2ZAFE@2|Bacteria	2|Bacteria	S	Putative ATP-binding cassette	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran_2
k59_830995_1	1121935.AQXX01000084_gene5360	2.17e-45	157.0	COG2230@1|root,COG2230@2|Bacteria,1MUW5@1224|Proteobacteria,1RPUC@1236|Gammaproteobacteria,1XIAF@135619|Oceanospirillales	135619|Oceanospirillales	M	Cyclopropane fatty acid synthase and related	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_713898_1	365046.Rta_05740	5.23e-70	227.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria,4AAKU@80864|Comamonadaceae	28216|Betaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_1183622_1	349124.Hhal_1056	8.76e-54	188.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales	135613|Chromatiales	E	glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1183622_2	395493.BegalDRAFT_2301	6.21e-99	301.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,45ZPY@72273|Thiotrichales	72273|Thiotrichales	E	Glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_1243959_1	1123279.ATUS01000001_gene2741	1.37e-09	63.9	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1J4S5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	COG4942 Membrane-bound metallopeptidase	envC	GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1005841_1	593907.Celgi_2448	6.35e-285	797.0	COG1501@1|root,COG1501@2|Bacteria,2GP4V@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	Gal_mutarotas_2,Glyco_hydro_31
k59_1068425_1	1279009.ADICEAN_01016	6.52e-42	142.0	COG4319@1|root,COG4319@2|Bacteria,4NTMK@976|Bacteroidetes,47X83@768503|Cytophagia	976|Bacteroidetes	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
k59_1478981_1	765912.Thimo_1564	1.99e-41	155.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales	135613|Chromatiales	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_1005847_1	1171373.PACID_32740	9.45e-07	52.0	COG0038@1|root,COG0038@2|Bacteria,2GPPN@201174|Actinobacteria	201174|Actinobacteria	P	Chloride channel	clcA	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	Voltage_CLC
k59_1005847_2	335543.Sfum_1609	9.8e-27	108.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MQAN@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	TIGRFAM ribonuclease, Rne Rng family	cafA	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_1359180_1	471853.Bcav_3110	3.98e-54	176.0	COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria	201174|Actinobacteria	GK	polyphosphate glucokinase	ppgK	-	2.7.1.2,2.7.1.63	ko:K00845,ko:K00886	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786,R02187,R02189	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_1653437_1	1123274.KB899416_gene2615	1.44e-50	172.0	COG1319@1|root,COG1319@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	-	-	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_1833259_1	557598.LHK_03094	2.01e-22	98.2	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,2VPGP@28216|Betaproteobacteria,2KQN6@206351|Neisseriales	206351|Neisseriales	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_1243986_1	1049564.TevJSym_ak00410	2.59e-89	266.0	COG1704@1|root,COG1704@2|Bacteria,1R9YG@1224|Proteobacteria,1T06D@1236|Gammaproteobacteria,1J62H@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_1243986_2	1073999.BN137_1463	5.92e-39	137.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	yrdA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0009987,GO:0016043,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071840	-	-	-	-	-	-	-	-	-	-	Hexapep
k59_1711245_1	746697.Aeqsu_0624	1.29e-33	133.0	COG0457@1|root,COG0457@2|Bacteria,4NFMI@976|Bacteroidetes,1HZPZ@117743|Flavobacteriia	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
k59_1305115_1	1255043.TVNIR_3388	8.66e-71	224.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,1S0GF@1236|Gammaproteobacteria,1X0AW@135613|Chromatiales	135613|Chromatiales	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
k59_1068451_2	1312959.KI914630_gene1701	4.22e-31	121.0	COG2197@1|root,COG2267@1|root,COG2197@2|Bacteria,COG2267@2|Bacteria,2GN4Z@201174|Actinobacteria	201174|Actinobacteria	K	luxR family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,GerE
k59_302654_1	933262.AXAM01000106_gene2631	4.22e-16	77.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,42R11@68525|delta/epsilon subdivisions,2WMWN@28221|Deltaproteobacteria,2MMZB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_302654_2	1231190.NA8A_18120	1.87e-33	132.0	COG2067@1|root,COG2067@2|Bacteria,1RF1Y@1224|Proteobacteria,2VGDQ@28211|Alphaproteobacteria,43RP9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_478780_1	713586.KB900536_gene2810	3.4e-39	143.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RR4I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_478780_2	71139.XP_010066773.1	2.31e-07	54.3	COG0590@1|root,KOG1018@2759|Eukaryota,37M2H@33090|Viridiplantae,3GB9K@35493|Streptophyta	35493|Streptophyta	F	deaminase	-	GO:0002097,GO:0002100,GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008251,GO:0009451,GO:0009507,GO:0009536,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016553,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
k59_248965_1	1122604.JONR01000006_gene2654	8.88e-52	181.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,1RN57@1236|Gammaproteobacteria,1X48I@135614|Xanthomonadales	135614|Xanthomonadales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
k59_248965_2	1177181.T9A_00960	3.45e-41	154.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1XHS4@135619|Oceanospirillales	135619|Oceanospirillales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_1535149_1	1121918.ARWE01000001_gene2528	3.56e-28	109.0	COG0583@1|root,COG0583@2|Bacteria,1MZX1@1224|Proteobacteria,42Q0Y@68525|delta/epsilon subdivisions,2WMJA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	LysR substrate binding domain	ilvY	-	-	ko:K02521	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_1535149_2	744872.Spica_1647	6.97e-59	183.0	COG0347@1|root,COG0347@2|Bacteria,2J7M4@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the P(II) protein family	-	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
k59_1123254_1	391165.GbCGDNIH1_1024	8.57e-69	217.0	COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,2TVXU@28211|Alphaproteobacteria,2JQS6@204441|Rhodospirillales	204441|Rhodospirillales	C	Oxidoreductase FAD-binding domain	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
k59_248976_1	1304865.JAGF01000001_gene226	3.12e-111	339.0	COG0747@1|root,COG0747@2|Bacteria,2GMMG@201174|Actinobacteria	201174|Actinobacteria	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1244005_1	990285.RGCCGE502_16365	1.01e-68	219.0	COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2TSX2@28211|Alphaproteobacteria,4BA0J@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
k59_952934_1	1049564.TevJSym_ab00630	4.59e-69	221.0	COG0577@1|root,COG0577@2|Bacteria,1QRYR@1224|Proteobacteria,1S0ZU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	tagS	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_478790_1	644282.Deba_0692	2.89e-115	345.0	COG2070@1|root,COG2070@2|Bacteria,1QZ4T@1224|Proteobacteria,43CFR@68525|delta/epsilon subdivisions,2X7QT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Conserved region in glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
k59_770916_1	590998.Celf_1851	3.45e-199	571.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4F0RF@85016|Cellulomonadaceae	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_655291_1	1124780.ANNU01000013_gene3832	1.49e-39	148.0	COG0476@1|root,COG0476@2|Bacteria,4NFUD@976|Bacteroidetes,47KG8@768503|Cytophagia	976|Bacteroidetes	H	MoeZ MoeB domain	moeB	-	2.7.7.80,2.8.1.11	ko:K21029,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
k59_1068470_1	243233.MCA0318	6.13e-61	206.0	COG1858@1|root,COG1999@1|root,COG1858@2|Bacteria,COG1999@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1XERF@135618|Methylococcales	135618|Methylococcales	C	PFAM Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
k59_365708_1	1123247.AUIJ01000002_gene2305	0.00023	45.4	COG1734@1|root,COG1734@2|Bacteria,1N8K6@1224|Proteobacteria,2UCF1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	DnaK suppressor protein	dskA	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
k59_1653466_2	1500893.JQNB01000001_gene1518	1.11e-49	164.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RMWT@1236|Gammaproteobacteria,1X2XT@135614|Xanthomonadales	135614|Xanthomonadales	KT	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoP	-	-	ko:K07660	ko01503,ko02020,map01503,map02020	M00444,M00709,M00721,M00723,M00724,M00744	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_15325_1	1312959.KI914692_gene2794	9.1e-77	245.0	COG1125@1|root,COG1125@2|Bacteria,2GJHI@201174|Actinobacteria,1W80J@1268|Micrococcaceae	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran,CBS
k59_1418679_1	399739.Pmen_0539	4.27e-49	176.0	COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,1RSQ1@1236|Gammaproteobacteria,1YETT@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_1244017_1	1158165.KB898875_gene19	1.76e-34	129.0	COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1WWZ8@135613|Chromatiales	135613|Chromatiales	S	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_1244017_2	748658.KB907313_gene2188	3.08e-29	108.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,1S3PT@1236|Gammaproteobacteria,1WX50@135613|Chromatiales	135613|Chromatiales	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
k59_1005873_1	585531.HMPREF0063_10868	6.04e-59	201.0	COG2303@1|root,COG2303@2|Bacteria,2GJ3J@201174|Actinobacteria,4DU71@85009|Propionibacteriales	201174|Actinobacteria	E	GMC oxidoreductase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,GMC_oxred_C,GMC_oxred_N
k59_1183669_1	84531.JMTZ01000008_gene3359	1.29e-14	79.7	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,1RPRP@1236|Gammaproteobacteria,1X56U@135614|Xanthomonadales	135614|Xanthomonadales	S	Penicillin acylase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_1068477_2	360094.PXO_03091	1.79e-20	86.7	COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,1X5Z3@135614|Xanthomonadales	135614|Xanthomonadales	S	Nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ	yajQ	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
k59_655300_1	450380.JPSY01000001_gene843	1.15e-53	184.0	COG2865@1|root,COG2865@2|Bacteria,2I3IG@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
k59_1833300_1	1121405.dsmv_2224	1.03e-39	152.0	COG0577@1|root,COG2234@1|root,COG0577@2|Bacteria,COG2234@2|Bacteria,1MVYE@1224|Proteobacteria,42PKN@68525|delta/epsilon subdivisions,2WIWP@28221|Deltaproteobacteria,2MIQI@213118|Desulfobacterales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,PA,Peptidase_M28
k59_1769720_1	1499502.EV12_2836	1.42e-67	230.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1G2E2@1117|Cyanobacteria,1MMDC@1212|Prochloraceae	1117|Cyanobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	nifJ	GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iJN678.nifJ	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1535169_1	1298867.AUES01000012_gene5513	1.26e-78	254.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3JUXK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,MHYT,PAS_4,PAS_7,dCache_1
k59_1305150_1	1068978.AMETH_5723	3.82e-79	251.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4DZMW@85010|Pseudonocardiales	201174|Actinobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_72255_1	566466.NOR53_465	1.23e-57	196.0	COG3746@1|root,COG3746@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07221	-	-	-	-	ko00000,ko02000	1.B.5.1	-	-	Porin_O_P
k59_1535176_1	247490.KSU1_D0575	6.24e-08	59.3	COG0475@1|root,COG0475@2|Bacteria,2J250@203682|Planctomycetes	203682|Planctomycetes	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1359218_1	1304865.JAGF01000001_gene1292	4.89e-229	647.0	COG0187@1|root,COG0187@2|Bacteria,2GKGP@201174|Actinobacteria,4F0P7@85016|Cellulomonadaceae	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_1123283_1	395493.BegalDRAFT_0278	8.51e-116	347.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,4600M@72273|Thiotrichales	72273|Thiotrichales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1068503_1	1122223.KB890687_gene2622	2.77e-07	55.1	COG1956@1|root,COG2199@1|root,COG1956@2|Bacteria,COG3706@2|Bacteria,1WITS@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	TIGRFAM diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
k59_655320_1	911045.PSE_p0347	6.6e-87	269.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TRJV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	ssdA	-	-	-	-	-	-	-	-	-	-	-	Aldedh
k59_655320_2	388739.RSK20926_13949	2.67e-31	119.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TSX8@28211|Alphaproteobacteria,2P2RY@2433|Roseobacter	28211|Alphaproteobacteria	C	COG1454 Alcohol dehydrogenase, class IV	mdh1	-	1.1.1.1,1.1.1.61	ko:K00001,ko:K00043	ko00010,ko00071,ko00350,ko00625,ko00626,ko00650,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00010,map00071,map00350,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220	-	R00623,R00754,R01644,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
k59_302698_1	861454.HMPREF9099_02484	4.11e-07	51.2	COG1028@1|root,COG1028@2|Bacteria,1TPZ8@1239|Firmicutes,24903@186801|Clostridia,27KAS@186928|unclassified Lachnospiraceae	186801|Clostridia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
k59_1244057_1	1150398.JIBJ01000021_gene3737	2.12e-79	247.0	COG4221@1|root,COG4221@2|Bacteria,2I2SK@201174|Actinobacteria,1WAWH@1268|Micrococcaceae	201174|Actinobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_479774_1	622637.KE124774_gene2186	1.97e-93	290.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2TRQ2@28211|Alphaproteobacteria,371CQ@31993|Methylocystaceae	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_186680_1	981384.AEYW01000001_gene1602	5.06e-134	400.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_1480471_1	1123257.AUFV01000005_gene1412	3.79e-09	63.2	COG5373@1|root,COG5373@2|Bacteria,1QZY0@1224|Proteobacteria,1SDQG@1236|Gammaproteobacteria,1X8J6@135614|Xanthomonadales	135614|Xanthomonadales	S	Type II secretion system protein B	-	-	-	-	-	-	-	-	-	-	-	-	T2SSB
k59_1480471_2	1300345.LF41_2539	1.31e-08	59.3	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1X4ZI@135614|Xanthomonadales	135614|Xanthomonadales	U	AAA domain	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
k59_1006679_1	272560.BPSS0452	1.65e-37	143.0	COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,2VJIQ@28216|Betaproteobacteria,1K4RW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA polymerase	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
k59_771747_1	1201290.M902_0663	5.22e-54	183.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2WJJ8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
k59_661350_1	326297.Sama_1420	7.27e-61	212.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q9NW@267890|Shewanellaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	mdtB	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_543408_1	396588.Tgr7_1968	3.28e-71	225.0	COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,1RM9B@1236|Gammaproteobacteria,1WWRA@135613|Chromatiales	135613|Chromatiales	N	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	-	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
k59_543408_2	626887.J057_01264	2.14e-15	78.6	COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,1RN6T@1236|Gammaproteobacteria,464NW@72275|Alteromonadaceae	1236|Gammaproteobacteria	N	The M ring may be actively involved in energy transduction	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
k59_1077811_1	1268303.RHODMAR_2879	1.14e-21	93.2	COG0133@1|root,COG0133@2|Bacteria,2GM7Z@201174|Actinobacteria,4FV0A@85025|Nocardiaceae	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PALP
k59_1077811_2	1123065.ATWL01000001_gene455	1.1e-80	247.0	COG0159@1|root,COG0159@2|Bacteria,2GN6T@201174|Actinobacteria	201174|Actinobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_308494_1	322710.Avin_15390	1.78e-43	150.0	28NM7@1|root,2ZBMT@2|Bacteria,1R9Y9@1224|Proteobacteria,1S227@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	DUF2959
k59_543409_1	935839.JAGJ01000011_gene451	9.77e-134	393.0	COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria,4F4EM@85017|Promicromonosporaceae	201174|Actinobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
k59_373995_1	765912.Thimo_2176	1.47e-89	281.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1WVWH@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_258027_1	765910.MARPU_02150	1.29e-22	95.9	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1WWW0@135613|Chromatiales	135613|Chromatiales	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
k59_258027_2	765911.Thivi_2511	3.36e-56	187.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1WWQM@135613|Chromatiales	135613|Chromatiales	P	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_484630_1	649754.HMPREF0281_01139	6.62e-43	155.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,22M3S@1653|Corynebacteriaceae	201174|Actinobacteria	M	exporter of polyketide antibiotics	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_661355_1	1121914.AUDW01000030_gene1249	3.18e-09	64.3	COG3266@1|root,COG3583@1|root,COG3266@2|Bacteria,COG3583@2|Bacteria,1TVFD@1239|Firmicutes,4I2CN@91061|Bacilli,3WFIX@539002|Bacillales incertae sedis	91061|Bacilli	S	G5	-	-	-	-	-	-	-	-	-	-	-	-	G5
k59_1541091_1	1121396.KB892910_gene4172	9.61e-72	229.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIQF@213118|Desulfobacterales	28221|Deltaproteobacteria	T	response regulator receiver	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_308505_1	204669.Acid345_1516	8.38e-20	89.4	COG1449@1|root,COG1449@2|Bacteria,3Y36M@57723|Acidobacteria,2JM7G@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_308505_2	1382306.JNIM01000001_gene280	7.58e-59	196.0	COG1449@1|root,COG1449@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	3.2.1.1	ko:K01176,ko:K07405	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13,GH57	-	Glyco_hydro_57
k59_1424756_1	1121406.JAEX01000017_gene1911	2.75e-33	123.0	COG2995@1|root,COG2995@2|Bacteria,1RAQ9@1224|Proteobacteria,42TYA@68525|delta/epsilon subdivisions,2WQ76@28221|Deltaproteobacteria,2MF5E@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_1077834_1	391615.ABSJ01000014_gene1624	8.9e-86	266.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,1J5GM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_1077834_2	270374.MELB17_16378	1.84e-15	77.4	COG0004@1|root,COG5001@1|root,COG0004@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,464Y3@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	GGDEF domain	-	-	2.1.1.80,3.1.1.61	ko:K03320,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02000,ko02022,ko02035	1.A.11	-	-	Ammonium_transp,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9
k59_961247_1	1121878.AUGL01000031_gene3505	2.54e-75	237.0	COG0131@1|root,COG0241@1|root,COG0131@2|Bacteria,COG0241@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Histidine biosynthesis bifunctional protein HisB	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15,4.2.1.19	ko:K01089,ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013,R03457	RC00017,RC00932	ko00000,ko00001,ko00002,ko01000	-	-	iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iUMNK88_1353.UMNK88_2570	Hydrolase_like,IGPD,PNK3P
k59_543427_1	69328.PVLB_11355	4.76e-10	63.9	2E9FY@1|root,333P7@2|Bacteria,1N8S6@1224|Proteobacteria,1S77C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_902296_1	450380.JPSY01000001_gene1186	7.31e-66	221.0	29GCA@1|root,303A5@2|Bacteria,2H1W0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1659621_1	2340.JV46_04620	1.02e-29	120.0	COG0526@1|root,COG0526@2|Bacteria,1MWDE@1224|Proteobacteria,1S0NV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
k59_1189785_1	1266914.ATUK01000014_gene2006	9.12e-53	171.0	COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,1S3PQ@1236|Gammaproteobacteria,1WXC4@135613|Chromatiales	135613|Chromatiales	L	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
k59_1189785_2	472759.Nhal_3285	1.16e-58	188.0	COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria,1WXJF@135613|Chromatiales	135613|Chromatiales	E	HAD-superfamily subfamily IB hydrolase, TIGR01490	-	-	-	-	-	-	-	-	-	-	-	-	HAD
k59_425874_1	420324.KI912061_gene6192	5.81e-30	120.0	COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,2U2BQ@28211|Alphaproteobacteria,1JYYS@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Response_reg
k59_1841648_1	765913.ThidrDRAFT_2067	5.36e-81	248.0	COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,1SYJC@1236|Gammaproteobacteria,1WW83@135613|Chromatiales	135613|Chromatiales	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_719984_1	1249627.D779_3324	4.04e-20	85.5	COG0589@1|root,COG0589@2|Bacteria,1NB6E@1224|Proteobacteria,1SEN6@1236|Gammaproteobacteria,1WZ7A@135613|Chromatiales	135613|Chromatiales	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_719984_2	156889.Mmc1_2438	4.41e-42	154.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,2TRF9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Na phosphate symporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
k59_1365184_1	1123288.SOV_3c05780	2.78e-24	103.0	COG0577@1|root,COG0577@2|Bacteria,1U388@1239|Firmicutes,4H32X@909932|Negativicutes	909932|Negativicutes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1365184_2	391615.ABSJ01000054_gene1396	0.000148	45.4	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,1RNEH@1236|Gammaproteobacteria,1J4HF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component	nasD	-	-	ko:K15578	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16.1	-	-	ABC_tran
k59_661387_1	1121372.AULK01000002_gene928	1.35e-33	120.0	COG3118@1|root,COG3118@2|Bacteria,2IHQV@201174|Actinobacteria,4FSJP@85023|Microbacteriaceae	201174|Actinobacteria	O	Thioredoxin	-	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
k59_661387_2	1206101.AZXC01000001_gene4770	7.14e-38	140.0	COG0531@1|root,COG0531@2|Bacteria,2GMTD@201174|Actinobacteria	201174|Actinobacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_258073_1	314285.KT71_03017	9.04e-49	176.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1RWT6@1236|Gammaproteobacteria,1J7Y7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1077859_1	316057.RPD_1531	6.08e-100	296.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2TR4R@28211|Alphaproteobacteria,3JTAE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	MA20_01040	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
k59_1010751_1	1268068.PG5_61310	1.11e-27	111.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_1010751_2	365046.Rta_16840	1.86e-11	64.7	COG0564@1|root,COG0564@2|Bacteria,1N8GW@1224|Proteobacteria,2VKYT@28216|Betaproteobacteria,4ACY1@80864|Comamonadaceae	28216|Betaproteobacteria	J	PFAM Pseudouridine synthase	truC	-	5.4.99.26	ko:K06175	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_2
k59_661392_2	1121104.AQXH01000001_gene1180	2.87e-29	116.0	COG2265@1|root,COG2265@2|Bacteria,4NFP1@976|Bacteroidetes,1IQPD@117747|Sphingobacteriia	976|Bacteroidetes	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_661394_1	1297569.MESS2_1080051	5.87e-09	53.9	2DR1A@1|root,339RT@2|Bacteria,1NGFB@1224|Proteobacteria,2V0ZB@28211|Alphaproteobacteria,43MEG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3096
k59_661394_2	178901.AmDm5_1955	9.93e-06	48.1	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,2TQME@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0025 NhaP-type Na H and K H antiporters	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
k59_308548_1	987059.RBXJA2T_13449	9.7e-51	164.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2VR7B@28216|Betaproteobacteria,1KKXV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
k59_1541133_1	1249627.D779_1687	1.02e-101	320.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1RQK9@1236|Gammaproteobacteria,1WWPF@135613|Chromatiales	135613|Chromatiales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.6	ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1775558_1	765912.Thimo_1721	3.92e-101	325.0	COG0247@1|root,COG0277@1|root,COG0479@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG0479@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales	135613|Chromatiales	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_837715_1	1304878.AUGD01000012_gene4099	4.71e-85	261.0	COG0577@1|root,COG0577@2|Bacteria,1MVSU@1224|Proteobacteria,2TUN8@28211|Alphaproteobacteria,3JVMV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_309202_2	754477.Q7C_2637	1.36e-53	175.0	COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,1SAHT@1236|Gammaproteobacteria,460YF@72273|Thiotrichales	72273|Thiotrichales	I	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_1717742_1	713587.THITH_17295	4.7e-32	124.0	28I2K@1|root,2Z86N@2|Bacteria,1R1GA@1224|Proteobacteria,1RRPU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_25134_1	1121875.KB907546_gene2720	0.0	944.0	28HMZ@1|root,2Z7WD@2|Bacteria,4P095@976|Bacteroidetes,1I89H@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_720642_1	471853.Bcav_3039	1.09e-26	102.0	2E65S@1|root,330UF@2|Bacteria,2IMEQ@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF3817
k59_1365893_1	335543.Sfum_3770	2.09e-53	172.0	COG1259@1|root,COG1259@2|Bacteria	2|Bacteria	K	PFAM Uncharacterised ACR, COG1259	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03617,ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase,UVR
k59_602445_1	631362.Thi970DRAFT_03295	1.29e-113	338.0	COG2801@1|root,COG2801@2|Bacteria,1R6TH@1224|Proteobacteria,1RRWS@1236|Gammaproteobacteria,1X2I8@135613|Chromatiales	135613|Chromatiales	L	Mu transposase, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,Mu-transpos_C,rve
k59_1365894_1	243365.CV_2381	5e-10	58.2	2ADG1@1|root,31364@2|Bacteria,1PRVI@1224|Proteobacteria,2VYNX@28216|Betaproteobacteria,2KS61@206351|Neisseriales	206351|Neisseriales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1365894_2	382245.ASA_4204	1.43e-20	89.0	COG1999@1|root,COG1999@2|Bacteria,1RHSV@1224|Proteobacteria,1S6HW@1236|Gammaproteobacteria,1Y5P2@135624|Aeromonadales	135624|Aeromonadales	S	SCO1/SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
k59_544064_1	1182590.BN5_00015	1.43e-46	159.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,1YF4N@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	J	Glycyl-tRNA synthetase alpha subunit	glyQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF1260.b3560,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360	tRNA-synt_2e
k59_776304_1	926569.ANT_25330	7.42e-53	179.0	COG1502@1|root,COG1502@2|Bacteria,2G8RC@200795|Chloroflexi	200795|Chloroflexi	I	PFAM phospholipase D Transphosphatidylase	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
k59_1190450_1	765952.PUV_08220	5.67e-05	53.1	COG2911@1|root,COG2911@2|Bacteria,2JG5X@204428|Chlamydiae	204428|Chlamydiae	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
k59_1129070_1	933262.AXAM01000056_gene3179	2.99e-108	330.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1R68U@1224|Proteobacteria,42M71@68525|delta/epsilon subdivisions,2WKG0@28221|Deltaproteobacteria,2MJ02@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD
k59_1600142_1	1304885.AUEY01000001_gene3242	4.31e-18	77.8	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,42TRE@68525|delta/epsilon subdivisions,2WQBH@28221|Deltaproteobacteria,2MKFE@213118|Desulfobacterales	28221|Deltaproteobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_1600142_2	207559.Dde_2253	3.45e-48	155.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,42THY@68525|delta/epsilon subdivisions,2WQ0F@28221|Deltaproteobacteria,2MBZW@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_1252879_1	450380.JPSY01000001_gene435	5.06e-47	159.0	COG1704@1|root,COG1704@2|Bacteria,2GPS4@201174|Actinobacteria,4FK45@85023|Microbacteriaceae	201174|Actinobacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_1487859_1	997346.HMPREF9374_0897	6.23e-40	144.0	COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,4HBCU@91061|Bacilli,27BCT@186824|Thermoactinomycetaceae	91061|Bacilli	I	Acyl transferase domain	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
k59_133727_1	472759.Nhal_1964	6.73e-40	154.0	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1WVVA@135613|Chromatiales	135613|Chromatiales	NU	FimV C-terminal	-	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	TPR_19
k59_1487863_1	519989.ECTPHS_12823	9.4e-116	351.0	COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,1X01D@135613|Chromatiales	135613|Chromatiales	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB	hscA	-	-	ko:K04044	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
k59_81427_1	1172188.KB911820_gene2201	1.1e-70	232.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria,4FFS7@85021|Intrasporangiaceae	201174|Actinobacteria	O	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1842576_1	1267005.KB911257_gene908	1.1e-18	90.9	COG4223@1|root,COG4223@2|Bacteria,1N3EE@1224|Proteobacteria,2VAHJ@28211|Alphaproteobacteria,3N97M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	DZ	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1541837_1	1049564.TevJSym_ad00280	4.09e-76	244.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1J4U3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CP	CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	-	-	1.6.5.3	ko:K05577	ko00190,ko01100,map00190,map01100	M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	-	-	-	Proton_antipo_M,Proton_antipo_N
k59_1776247_1	58123.JOFJ01000021_gene3923	5.52e-29	120.0	COG0318@1|root,COG0318@2|Bacteria,2GKDF@201174|Actinobacteria,4EM74@85012|Streptosporangiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_1314407_1	765911.Thivi_2855	9.6e-16	74.3	COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,1S6VJ@1236|Gammaproteobacteria,1WYAC@135613|Chromatiales	135613|Chromatiales	NU	pilus assembly protein PilP	-	-	-	ko:K02665	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilP
k59_1314407_2	1049564.TevJSym_bb00160	9.07e-72	223.0	COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1J6DF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	Pilus assembly protein, PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
k59_81431_1	546274.EIKCOROL_01574	1.59e-109	327.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2VIBN@28216|Betaproteobacteria,2KPVD@206351|Neisseriales	206351|Neisseriales	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_426549_1	713586.KB900536_gene487	1.16e-12	67.8	COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,1WWKI@135613|Chromatiales	135613|Chromatiales	G	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane	lapB	-	-	ko:K19804	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_7
k59_426549_2	572477.Alvin_1644	1.4e-48	157.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,1S8XZ@1236|Gammaproteobacteria,1WYM5@135613|Chromatiales	135613|Chromatiales	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_426549_3	519989.ECTPHS_08271	1.68e-177	509.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1WVVK@135613|Chromatiales	135613|Chromatiales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_1600159_1	713586.KB900536_gene1923	1e-92	293.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales	135613|Chromatiales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_375007_1	240015.ACP_1314	6.73e-37	130.0	COG3293@1|root,COG3293@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096,Recombinase,Resolvase,Zn_ribbon_recom
k59_1078797_1	1267005.KB911259_gene4038	4.38e-59	198.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2U0DN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	BT1
k59_837761_1	196162.Noca_2853	2.76e-25	103.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4DQ18@85009|Propionibacteriales	201174|Actinobacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_837761_2	58123.JOFJ01000005_gene1331	3.64e-37	140.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,2GJ50@201174|Actinobacteria,4EG1F@85012|Streptosporangiales	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	fadB	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_1129090_1	349521.HCH_01789	2.81e-180	516.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1XH52@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_544098_1	667014.Thein_0383	6.78e-43	146.0	COG1126@1|root,COG1126@2|Bacteria	2|Bacteria	E	abc transporter atp-binding protein	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
k59_544098_2	1379270.AUXF01000006_gene133	9.57e-13	68.2	COG1077@1|root,COG1077@2|Bacteria,1ZT9B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Hsp70 protein	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_309245_1	1449049.JONW01000005_gene1731	2.4e-33	122.0	COG1917@1|root,COG1917@2|Bacteria,1RB5Y@1224|Proteobacteria,2U5TF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1496014_1	76114.p2A67	5.8e-88	278.0	COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,2VJBZ@28216|Betaproteobacteria,2KV77@206389|Rhodocyclales	206389|Rhodocyclales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_844458_1	662755.CRES_0824	3.11e-210	606.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,22KHA@1653|Corynebacteriaceae	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_1432308_1	498211.CJA_1616	7.48e-80	243.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,1RMG1@1236|Gammaproteobacteria,1FH17@10|Cellvibrio	1236|Gammaproteobacteria	Q	ATPases associated with a variety of cellular activities	ybbA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_433175_1	1232437.KL662058_gene3955	1.98e-30	115.0	COG1433@1|root,COG1433@2|Bacteria,1NKUY@1224|Proteobacteria,42XKV@68525|delta/epsilon subdivisions,2WSWQ@28221|Deltaproteobacteria,2MM9Y@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Dinitrogenase iron-molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
k59_1372295_1	1207063.P24_01460	3.7e-106	337.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2TQJW@28211|Alphaproteobacteria,2JPZU@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narZ	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
k59_36448_1	272134.KB731326_gene335	1.29e-140	417.0	COG3666@1|root,COG3666@2|Bacteria,1GEUC@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1496028_1	314278.NB231_13336	1.15e-34	125.0	COG0835@1|root,COG0835@2|Bacteria,1RCIR@1224|Proteobacteria,1SC4F@1236|Gammaproteobacteria,1X2EV@135613|Chromatiales	135613|Chromatiales	NT	Two component signalling adaptor domain	-	-	-	ko:K02659	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	CheW
k59_1496028_2	95619.PM1_0226555	2.61e-30	109.0	COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,1S4NE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KT	Type IV pilus response regulator PilH	pilH	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_972297_1	1353531.AZNX01000005_gene3261	3.84e-46	174.0	COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2U4F6@28211|Alphaproteobacteria,4BCVF@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
k59_384969_2	446466.Cfla_2429	1.79e-50	181.0	COG1074@1|root,COG1074@2|Bacteria,2GNKH@201174|Actinobacteria	201174|Actinobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1852765_1	187272.Mlg_0002	1.45e-87	271.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1WWQF@135613|Chromatiales	135613|Chromatiales	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	-	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_1087391_1	471853.Bcav_3251	8.65e-74	235.0	COG0755@1|root,COG0755@2|Bacteria,2GJR1@201174|Actinobacteria	201174|Actinobacteria	O	cytochrome C	ccsB	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
k59_1606397_1	1121939.L861_07930	1.85e-38	148.0	COG1234@1|root,COG1234@2|Bacteria,1PPRD@1224|Proteobacteria,1RRV8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Beta-lactamase superfamily domain	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	CLP1_P,Lactamase_B,Lactamase_B_2
k59_1724596_1	1304865.JAGF01000001_gene3789	2.74e-49	166.0	COG0196@1|root,COG0196@2|Bacteria,2GKQF@201174|Actinobacteria,4F0UH@85016|Cellulomonadaceae	201174|Actinobacteria	H	TIGRFAM riboflavin biosynthesis protein RibF	ribF	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
k59_609272_1	880072.Desac_0716	2.9e-57	197.0	COG4191@1|root,COG4191@2|Bacteria,1RI33@1224|Proteobacteria,42SUG@68525|delta/epsilon subdivisions,2WP3A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	bamV	-	2.7.13.3	ko:K10125	ko02020,map02020	M00504	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,dCache_1
k59_91509_1	1342301.JASD01000001_gene269	3.34e-113	352.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2TTPX@28211|Alphaproteobacteria,3ZWCP@60136|Sulfitobacter	28211|Alphaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	fdhF	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_492011_1	1432055.GLUCORHAEAF1_13510	6.09e-108	323.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2TQQP@28211|Alphaproteobacteria,2JPSN@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
k59_1852781_1	1267535.KB906767_gene2030	2.14e-22	94.0	COG1484@1|root,COG1484@2|Bacteria,3Y4QK@57723|Acidobacteria,2JNWI@204432|Acidobacteriia	204432|Acidobacteriia	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,IstB_IS21_ATP
k59_1852781_2	768671.ThimaDRAFT_1929	6.07e-26	107.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,1RQA2@1236|Gammaproteobacteria,1WYPQ@135613|Chromatiales	135613|Chromatiales	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_384998_2	502025.Hoch_3702	2.26e-30	120.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,2YU45@29|Myxococcales	28221|Deltaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_972334_1	1246995.AFR_08415	1.47e-14	76.3	COG1309@1|root,COG1309@2|Bacteria,2GV75@201174|Actinobacteria,4DCQK@85008|Micromonosporales	201174|Actinobacteria	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
k59_609282_1	335543.Sfum_3013	4.63e-99	317.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
k59_385009_1	706587.Desti_1914	1.64e-87	268.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42N5J@68525|delta/epsilon subdivisions,2WJ6B@28221|Deltaproteobacteria,2MR3T@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Cysteine-rich domain	bamD	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8
k59_844500_1	1380393.JHVP01000013_gene3431	6.49e-72	241.0	COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,2GISC@201174|Actinobacteria,4ERN6@85013|Frankiales	201174|Actinobacteria	L	SWIM zinc finger	helZ	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
k59_36488_1	748247.AZKH_p0058	1.15e-34	129.0	COG1143@1|root,COG1145@1|root,COG1143@2|Bacteria,COG1145@2|Bacteria,1QVIN@1224|Proteobacteria,2VI64@28216|Betaproteobacteria,2KVVD@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
k59_36488_2	76114.ebA6416	7.77e-25	95.9	2AENS@1|root,314IU@2|Bacteria,1RINM@1224|Proteobacteria,2VTCG@28216|Betaproteobacteria,2KWJD@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1606412_1	1089552.KI911559_gene2243	1.66e-34	126.0	COG1126@1|root,COG1126@2|Bacteria,1MWKQ@1224|Proteobacteria,2TSCU@28211|Alphaproteobacteria,2JRVW@204441|Rhodospirillales	204441|Rhodospirillales	E	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_1606412_2	1288298.rosmuc_00064	6.46e-74	228.0	COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,2TUHN@28211|Alphaproteobacteria,46NDE@74030|Roseovarius	28211|Alphaproteobacteria	P	COG4662 ABC-type tungstate transport system, periplasmic component	MA20_34300	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
k59_270018_1	765911.Thivi_3112	1.31e-74	228.0	COG1150@1|root,COG1150@2|Bacteria,1R874@1224|Proteobacteria,1SHQ0@1236|Gammaproteobacteria,1WZZ0@135613|Chromatiales	135613|Chromatiales	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K16887	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_8
k59_1324524_1	1042375.AFPL01000036_gene3077	7.94e-58	191.0	COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,1S52W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C
k59_913311_1	1298867.AUES01000002_gene1290	3.41e-63	213.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,3JRU1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	phbC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
k59_1432360_1	2340.JV46_26330	7.37e-44	143.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,1J6MX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
k59_1432360_2	187272.Mlg_0847	9.29e-58	189.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1WX4T@135613|Chromatiales	135613|Chromatiales	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_913318_1	765913.ThidrDRAFT_1611	3.97e-92	285.0	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,1RQPH@1236|Gammaproteobacteria,1WX21@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_36509_1	1003195.SCAT_4920	2.19e-14	80.1	COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria	201174|Actinobacteria	I	carboxylase	accA2	-	6.4.1.1,6.4.1.3,6.4.1.4	ko:K01959,ko:K01965,ko:K01968	ko00020,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01120,ko01130,ko01200,ko01230,map00020,map00280,map00620,map00630,map00640,map00720,map01100,map01120,map01130,map01200,map01230	M00036,M00173,M00373,M00620,M00741	R00344,R01859,R04138	RC00040,RC00097,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0973c	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_316228_1	768671.ThimaDRAFT_1729	7.72e-273	754.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,1WVZV@135613|Chromatiales	135613|Chromatiales	P	PFAM Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_1667236_1	1121918.ARWE01000001_gene2300	2.36e-35	130.0	28PU4@1|root,2ZCF6@2|Bacteria,1RBK2@1224|Proteobacteria,43B3E@68525|delta/epsilon subdivisions,2X6H4@28221|Deltaproteobacteria,43U05@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_36525_1	1050202.KB913024_gene264	1.96e-14	76.3	COG0412@1|root,COG0412@2|Bacteria,2GKWS@201174|Actinobacteria,407FP@622450|Actinopolysporales	201174|Actinobacteria	Q	Chlorophyllase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Chlorophyllase,Chlorophyllase2,DLH
k59_550619_1	264198.Reut_B4232	1.5e-27	114.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VJIJ@28216|Betaproteobacteria,1JZQJ@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_1197345_2	765914.ThisiDRAFT_0886	2.24e-130	400.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1WWH1@135613|Chromatiales	135613|Chromatiales	M	TIGRFAM penicillin-binding protein, 1A	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_1606446_1	768671.ThimaDRAFT_4072	2.28e-59	197.0	28KQH@1|root,2ZA8A@2|Bacteria,1R5EQ@1224|Proteobacteria,1RRD9@1236|Gammaproteobacteria,1WXTM@135613|Chromatiales	135613|Chromatiales	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
k59_1496097_1	62928.azo1992	1.63e-106	326.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2VH2P@28216|Betaproteobacteria,2KUY7@206389|Rhodocyclales	206389|Rhodocyclales	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
k59_550623_1	743718.Isova_2595	1.1e-56	191.0	COG1061@1|root,COG1061@2|Bacteria,2GIR9@201174|Actinobacteria,4F49M@85017|Promicromonosporaceae	201174|Actinobacteria	L	ERCC3/RAD25/XPB C-terminal helicase	ercc3	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
k59_385073_1	1286106.MPL1_01204	3.09e-120	350.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,4603P@72273|Thiotrichales	72273|Thiotrichales	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_385073_2	765910.MARPU_01140	2.75e-86	281.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1WXIK@135613|Chromatiales	135613|Chromatiales	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_844535_1	69042.WH5701_09970	3.23e-33	124.0	COG3187@1|root,COG3187@2|Bacteria,1G96Y@1117|Cyanobacteria,1H3UY@1129|Synechococcus	1117|Cyanobacteria	O	META domain	-	-	-	ko:K03668	-	-	-	-	ko00000	-	-	-	DUF4377,META
k59_1197348_1	381666.H16_B0950	4.11e-76	232.0	COG2208@1|root,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	icfG	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,HATPase_c_2,SpoIIE,dCache_1
k59_1724656_1	545695.TREAZ_0498	1.01e-28	118.0	COG3666@1|root,COG3666@2|Bacteria,2J98U@203691|Spirochaetes	203691|Spirochaetes	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_433248_1	1096546.WYO_1022	7.74e-57	183.0	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2TU68@28211|Alphaproteobacteria,1JRKP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
k59_433248_2	414684.RC1_1593	8.18e-55	185.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JPSC@204441|Rhodospirillales	204441|Rhodospirillales	C	belongs to the aldehyde dehydrogenase family	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_492062_1	111780.Sta7437_0890	1.35e-14	78.2	COG4671@1|root,COG4671@2|Bacteria,1G0X1@1117|Cyanobacteria,3VJVG@52604|Pleurocapsales	1117|Cyanobacteria	S	PFAM Glycosyltransferase family 28 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	iJN678.sll1722	Glyco_tran_28_C
k59_550631_1	1123360.thalar_02506	2.13e-137	395.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve
k59_1782800_1	375286.mma_1634	4.68e-118	348.0	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2VHGS@28216|Betaproteobacteria,4726F@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex	ccoP	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
k59_1782800_2	243365.CV_2381	3.13e-07	51.6	2ADG1@1|root,31364@2|Bacteria,1PRVI@1224|Proteobacteria,2VYNX@28216|Betaproteobacteria,2KS61@206351|Neisseriales	206351|Neisseriales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_91623_1	1121405.dsmv_0480	1.01e-28	110.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,42N8B@68525|delta/epsilon subdivisions,2WJ6I@28221|Deltaproteobacteria,2MIR3@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_91623_2	933262.AXAM01000010_gene1387	2.86e-24	101.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2WIK7@28221|Deltaproteobacteria,2MIHR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_36563_1	439235.Dalk_5059	5.09e-32	124.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,42MZQ@68525|delta/epsilon subdivisions,2WJNE@28221|Deltaproteobacteria,2MHWG@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_1017080_1	484770.UFO1_1290	1.87e-87	274.0	COG0519@1|root,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,4H243@909932|Negativicutes	909932|Negativicutes	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,ThiI,tRNA_Me_trans
k59_1724674_1	1123371.ATXH01000001_gene1300	2.48e-93	300.0	COG0458@1|root,COG0458@2|Bacteria,2GH37@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	EF	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_1324624_1	1713.JOFV01000007_gene2919	1.26e-259	746.0	COG1038@1|root,COG1038@2|Bacteria,2H238@201174|Actinobacteria,4F1VZ@85016|Cellulomonadaceae	201174|Actinobacteria	C	Conserved carboxylase domain	pyc	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA
k59_972452_1	187272.Mlg_1362	9.26e-151	446.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1WWEF@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_972452_2	314278.NB231_01569	1.02e-13	70.1	COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,1S2B6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_316284_1	360107.CHAB381_0523	3.44e-45	154.0	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,42MJU@68525|delta/epsilon subdivisions,2YM7H@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iIT341.HP0646	NTP_transferase
k59_316284_2	300852.55772337	3.43e-12	67.8	COG3769@1|root,COG3769@2|Bacteria,1WMJU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.70	ko:K07026	ko00051,map00051	-	R05790	RC00017	ko00000,ko00001,ko01000	-	-	-	Hydrolase_3
k59_198948_1	263358.VAB18032_10165	3.85e-67	224.0	COG2234@1|root,COG2234@2|Bacteria,2HVJR@201174|Actinobacteria,4DHBB@85008|Micromonosporales	201174|Actinobacteria	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_385156_1	1121405.dsmv_3781	4.91e-177	501.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales	68525|delta/epsilon subdivisions	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_36595_1	1123368.AUIS01000009_gene2439	1.3e-52	188.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Glyco_hydro_77
k59_1324667_1	765910.MARPU_12710	5.6e-26	102.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1S5Y0@1236|Gammaproteobacteria,1WXYX@135613|Chromatiales	135613|Chromatiales	Q	TRAP-type mannitol chloroaromatic compound transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_433289_1	247633.GP2143_09500	4.9e-41	147.0	COG2974@1|root,COG2974@2|Bacteria,1MXPR@1224|Proteobacteria,1RMNN@1236|Gammaproteobacteria,1J58F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	May be involved in recombination	rdgC	GO:0000018,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009295,GO:0019219,GO:0019222,GO:0031323,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363	-	ko:K03554	-	-	-	-	ko00000,ko03400	-	-	-	RdgC
k59_972497_1	643867.Ftrac_1978	6.78e-44	169.0	COG0366@1|root,COG3291@1|root,COG0366@2|Bacteria,COG3291@2|Bacteria,4NEXF@976|Bacteroidetes,47MR6@768503|Cytophagia	976|Bacteroidetes	G	PFAM Alpha amylase, catalytic	-	GO:0000272,GO:0000287,GO:0001871,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005575,GO:0005975,GO:0005976,GO:0005982,GO:0005983,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0016020,GO:0016052,GO:0016160,GO:0016787,GO:0016798,GO:0019867,GO:0030246,GO:0030247,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0046872,GO:0071704,GO:1901575,GO:2001070	3.2.1.1,3.2.1.133,3.2.1.135,3.2.1.54	ko:K01176,ko:K01208	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R03122,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,BACON
k59_198956_1	1449347.JQLN01000005_gene4742	1.54e-14	74.7	COG1309@1|root,COG1309@2|Bacteria,2GNQ6@201174|Actinobacteria,2M3MP@2063|Kitasatospora	201174|Actinobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
k59_199693_1	344747.PM8797T_21498	3.68e-32	129.0	COG0515@1|root,COG0515@2|Bacteria,2IXG3@203682|Planctomycetes	203682|Planctomycetes	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	HDOD,Pkinase,dCache_1
k59_1854439_1	1121405.dsmv_1157	1.85e-67	230.0	COG0366@1|root,COG3408@1|root,COG0366@2|Bacteria,COG3408@2|Bacteria,1MWBZ@1224|Proteobacteria,43AE9@68525|delta/epsilon subdivisions,2X5U3@28221|Deltaproteobacteria,2MJ5S@213118|Desulfobacterales	28221|Deltaproteobacteria	G	alpha amylase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,GDE_C,GDE_N
k59_1017798_1	933262.AXAM01000010_gene1404	6.3e-82	259.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,42M3D@68525|delta/epsilon subdivisions,2WJEA@28221|Deltaproteobacteria,2MI7F@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_492894_1	1504319.GM45_5885	6.98e-125	379.0	COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,3UWBT@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Leucyl-tRNA synthetase, Domain 2	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1326161_1	1463825.JNXC01000020_gene6598	1.63e-14	79.7	COG4767@1|root,COG4767@2|Bacteria,2H595@201174|Actinobacteria,4E3Y3@85010|Pseudonocardiales	201174|Actinobacteria	V	Glycopeptide antibiotics resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	RDD,VanZ
k59_845352_1	395492.Rleg2_4409	1.28e-72	236.0	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,2TQPC@28211|Alphaproteobacteria,4B700@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_29,HTH_32,rve
k59_1554115_1	1151122.AQYD01000007_gene665	1.12e-43	166.0	COG2911@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG4625@1|root,COG4932@1|root,COG5373@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,COG4625@2|Bacteria,COG4932@2|Bacteria,COG5373@2|Bacteria	2|Bacteria	KLT	membrane	-	-	-	ko:K02451,ko:K03832,ko:K13735,ko:K20276,ko:K21449	ko02024,ko05100,map02024,map05100	M00331	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	1.B.40.2,2.C.1.1,9.B.42	-	-	PATR,T2SSB
k59_674650_1	296591.Bpro_5292	1.22e-93	281.0	COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,2VTA7@28216|Betaproteobacteria,4AHEH@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1268307_1	96561.Dole_0846	6.04e-33	127.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2MIGI@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM molybdopterin oxidoreductase	-	-	1.17.1.10,1.17.1.9	ko:K00123,ko:K05299	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1612323_1	768671.ThimaDRAFT_3827	7.06e-117	342.0	COG2878@1|root,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,1RPC4@1236|Gammaproteobacteria,1WWC5@135613|Chromatiales	135613|Chromatiales	C	Fe-S cluster	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4
k59_395478_1	497321.C664_18509	9.57e-46	158.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,2KU9J@206389|Rhodocyclales	206389|Rhodocyclales	NU	twitching motility protein	-	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_395478_2	1280390.CBQR020000146_gene3681	1.83e-11	62.4	COG0386@1|root,COG0386@2|Bacteria,1V3M3@1239|Firmicutes,4HH5Q@91061|Bacilli,26V63@186822|Paenibacillaceae	91061|Bacilli	O	Belongs to the glutathione peroxidase family	bsaA	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
k59_44929_1	593750.Metfor_1704	8.94e-79	249.0	COG0591@1|root,arCOG01316@2157|Archaea,2XU91@28890|Euryarchaeota	28890|Euryarchaeota	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307,ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21,2.A.21.2	-	-	SSF
k59_1335199_1	203124.Tery_2845	3.03e-37	141.0	COG0591@1|root,COG0591@2|Bacteria,1G3QJ@1117|Cyanobacteria,1HH5D@1150|Oscillatoriales	1117|Cyanobacteria	E	Sodium:solute symporter family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
k59_733217_1	1380354.JIAN01000006_gene432	3.56e-13	68.6	COG0147@1|root,COG0147@2|Bacteria,2GN7D@201174|Actinobacteria,4F1NN@85016|Cellulomonadaceae	201174|Actinobacteria	EH	chorismate binding enzyme	pabB	-	2.6.1.85,4.1.3.38	ko:K01665,ko:K03342	ko00790,map00790	-	R01716,R05553	RC00010,RC01418,RC01843,RC02148	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4,Chorismate_bind
k59_733217_2	367299.JOEE01000008_gene502	4.35e-70	219.0	COG0115@1|root,COG0115@2|Bacteria,2GN5Z@201174|Actinobacteria,4FE9F@85021|Intrasporangiaceae	201174|Actinobacteria	EH	Class IV aminotransferase	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_146407_1	1415780.JPOG01000001_gene1123	4.55e-27	105.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,1S3NR@1236|Gammaproteobacteria,1X6CC@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
k59_146407_2	768671.ThimaDRAFT_4372	1.97e-94	284.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,1RN90@1236|Gammaproteobacteria,1WW7R@135613|Chromatiales	135613|Chromatiales	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
k59_923943_1	545264.KB898754_gene1844	1.76e-06	52.8	COG0631@1|root,COG0631@2|Bacteria,1N72S@1224|Proteobacteria,1SBH5@1236|Gammaproteobacteria,1WZC2@135613|Chromatiales	135613|Chromatiales	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
k59_1378224_1	446471.Xcel_1027	1.21e-139	408.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4F3Y8@85017|Promicromonosporaceae	201174|Actinobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	dapC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.6.1.1,2.6.1.17	ko:K00812,ko:K14267	ko00220,ko00250,ko00270,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01130,map01210,map01230	M00016	R00355,R00694,R00734,R00896,R02433,R02619,R04475,R05052	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iNJ661.Rv0858c	Aminotran_1_2
k59_1203250_1	1193181.BN10_930026	2.05e-134	391.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4FF3P@85021|Intrasporangiaceae	201174|Actinobacteria	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_277925_1	335543.Sfum_1661	6.86e-84	273.0	COG1026@1|root,COG1026@2|Bacteria,1MVDJ@1224|Proteobacteria,42MRG@68525|delta/epsilon subdivisions,2WJ5Q@28221|Deltaproteobacteria,2MQW0@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Peptidase M16C associated	PREP	-	-	ko:K06972	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M16C_assoc,Peptidase_M16,Peptidase_M16_C
k59_44941_2	1122603.ATVI01000006_gene667	4.89e-44	150.0	COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,1S24F@1236|Gammaproteobacteria,1X4YF@135614|Xanthomonadales	135614|Xanthomonadales	S	Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
k59_733220_1	1380354.JIAN01000011_gene3256	5.8e-215	605.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase LigD polymerase domain	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
k59_1378226_2	1232437.KL662040_gene2135	7.13e-25	95.9	COG1359@1|root,COG1359@2|Bacteria,1NGPW@1224|Proteobacteria,42TXG@68525|delta/epsilon subdivisions,2WQI4@28221|Deltaproteobacteria,2MKN6@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
k59_44948_1	1219035.NT2_08_01240	3.56e-60	195.0	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_615284_2	335543.Sfum_1664	2.37e-50	166.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42RQX@68525|delta/epsilon subdivisions,2WNM1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_850426_1	1267005.KB911256_gene1982	3.98e-92	275.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2TRMI@28211|Alphaproteobacteria,3N6BC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	QU41_16170	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
k59_1730669_1	471853.Bcav_1241	5.63e-179	519.0	COG3850@1|root,COG5002@1|root,COG3850@2|Bacteria,COG5002@2|Bacteria,2GJ2D@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	mtrB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	2.7.13.3	ko:K07636,ko:K07654	ko02020,map02020	M00434,M00461	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_674677_1	244581.IM40_08215	2.4e-53	189.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,2TQWC@28211|Alphaproteobacteria,47EZE@766|Rickettsiales	766|Rickettsiales	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
k59_923972_1	335543.Sfum_1580	4.25e-71	216.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,42R43@68525|delta/epsilon subdivisions,2WPH1@28221|Deltaproteobacteria,2MQGH@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
k59_923972_2	335543.Sfum_1579	2.42e-69	211.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,42RE3@68525|delta/epsilon subdivisions,2WPD5@28221|Deltaproteobacteria,2MRU2@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_102069_1	1198452.Jab_1c08540	9.28e-93	289.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,473I1@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_615303_2	375286.mma_0731	1.92e-36	136.0	COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,47397@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Belongs to the peptidase S11 family	pbpG	-	-	ko:K07262	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
k59_787216_2	1123373.ATXI01000001_gene579	3.77e-05	47.0	COG0589@1|root,COG0589@2|Bacteria,2GH02@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1094104_1	1187848.AJYQ01000008_gene535	1.79e-66	212.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,1RQ31@1236|Gammaproteobacteria,1XV2J@135623|Vibrionales	135623|Vibrionales	E	COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_395545_2	1347368.HG964404_gene5314	4.95e-25	104.0	COG2311@1|root,COG2311@2|Bacteria,1V12A@1239|Firmicutes,4HEWA@91061|Bacilli,1ZBSJ@1386|Bacillus	91061|Bacilli	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF418
k59_983073_1	880072.Desac_2866	8.97e-22	94.7	COG0327@1|root,COG0327@2|Bacteria,1R34P@1224|Proteobacteria,42MAY@68525|delta/epsilon subdivisions,2X5HJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the GTP cyclohydrolase I type 2 NIF3 family	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
k59_925178_1	411684.HPDFL43_03701	6.48e-16	77.4	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2TTJZ@28211|Alphaproteobacteria,43JFR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_925178_2	991905.SL003B_1031	2.67e-24	104.0	COG0845@1|root,COG0845@2|Bacteria,1Q112@1224|Proteobacteria,2V906@28211|Alphaproteobacteria,4BSRF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3
k59_1554865_1	426114.THI_2411	3.33e-168	481.0	COG0446@1|root,COG0446@2|Bacteria,1QSG7@1224|Proteobacteria,2W9DB@28216|Betaproteobacteria,1KKDR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_615971_1	243233.MCA2343	5.53e-70	226.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1XE18@135618|Methylococcales	135618|Methylococcales	O	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_1336464_1	1121403.AUCV01000001_gene845	6.05e-51	182.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,42NB9@68525|delta/epsilon subdivisions,2WKTK@28221|Deltaproteobacteria,2MIXF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
k59_1788481_1	446469.Sked_01520	1.75e-147	431.0	COG0033@1|root,COG0033@2|Bacteria,2H1PI@201174|Actinobacteria	201174|Actinobacteria	G	Phosphoglucomutase	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_322982_1	933262.AXAM01000073_gene3358	5e-122	355.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2WJMN@28221|Deltaproteobacteria,2MIBA@213118|Desulfobacterales	28221|Deltaproteobacteria	J	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24,SEC-C
k59_925191_1	243233.MCA1846	5.33e-20	94.4	28HBC@1|root,2Z7ND@2|Bacteria,1NVFW@1224|Proteobacteria,1RPBA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Virulence effector protein	srfA	-	-	-	-	-	-	-	-	-	-	-	-
k59_1378993_1	666681.M301_1471	1.1e-14	73.9	COG3752@1|root,COG3752@2|Bacteria,1MXCP@1224|Proteobacteria,2VQHY@28216|Betaproteobacteria,2KKZM@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
k59_1378993_2	1101195.Meth11DRAFT_1304	6.62e-09	57.4	2CH72@1|root,32ZK4@2|Bacteria,1N8YD@1224|Proteobacteria,2VVUJ@28216|Betaproteobacteria,2KN4M@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Protein of unknown function (DUF2878)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2878
k59_1378993_3	887062.HGR_05419	9.03e-41	144.0	COG2230@1|root,COG2230@2|Bacteria,1MUW5@1224|Proteobacteria,2VI5F@28216|Betaproteobacteria,4ACT9@80864|Comamonadaceae	28216|Betaproteobacteria	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_45719_1	335543.Sfum_2075	5.82e-138	405.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,2MQ5R@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1276	CTP_synth_N,GATase
k59_103258_1	2340.JV46_24310	3.29e-30	110.0	COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,1S5WG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009898,GO:0010467,GO:0016020,GO:0016151,GO:0019538,GO:0019897,GO:0019898,GO:0031234,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:1901564	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
k59_615983_1	765913.ThidrDRAFT_4165	1.76e-59	192.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1WW4K@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_615983_2	519989.ECTPHS_08828	3.51e-50	172.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1WW2C@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1378999_1	46429.BV95_01047	1.28e-207	588.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2K24H@204457|Sphingomonadales	204457|Sphingomonadales	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1439042_1	446469.Sked_30210	4.39e-80	248.0	COG4152@1|root,COG4152@2|Bacteria,2I2DK@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_1439042_2	590998.Celf_1261	2.51e-29	119.0	COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria,4F0PF@85016|Cellulomonadaceae	201174|Actinobacteria	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_278712_1	670307.HYPDE_32268	3.89e-102	308.0	COG0626@1|root,COG0626@2|Bacteria,1MU9E@1224|Proteobacteria,2TS8Z@28211|Alphaproteobacteria,3N67U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	cystathionine beta-lyase	metC	-	4.4.1.8	ko:K01760	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1503449_1	426114.THI_2669	7.53e-19	86.3	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,2VJ8Q@28216|Betaproteobacteria,1KJFD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Thiosulfate-oxidizing multienzyme system protein SoxA	-	-	-	ko:K17222	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	-
k59_147154_1	369723.Strop_4139	1.23e-109	329.0	COG3344@1|root,COG3344@2|Bacteria,2GUJS@201174|Actinobacteria,4DDZN@85008|Micromonosporales	201174|Actinobacteria	L	Group II intron, maturase-specific domain	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1
k59_1141226_1	582899.Hden_0278	6.62e-144	425.0	COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,2TUN9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function DUF87	MA20_26515	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
k59_323012_2	768671.ThimaDRAFT_2921	2.67e-12	71.2	COG3659@1|root,COG3659@2|Bacteria,1PGW8@1224|Proteobacteria,1SHC7@1236|Gammaproteobacteria	2|Bacteria	M	Carbohydrate-selective porin, OprB family	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB,SLH
k59_1731393_1	1380354.JIAN01000009_gene3896	3.05e-14	75.9	COG2025@1|root,COG2025@2|Bacteria,2GJWH@201174|Actinobacteria,4F155@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM Electron transfer flavoprotein alpha subunit	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
k59_1673997_2	76114.ebA872	1.13e-90	271.0	COG0225@1|root,COG0225@2|Bacteria,1R33Z@1224|Proteobacteria,2VRHA@28216|Betaproteobacteria,2KYN1@206389|Rhodocyclales	206389|Rhodocyclales	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_1673997_3	941449.dsx2_2115	1.01e-74	240.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42MAP@68525|delta/epsilon subdivisions,2WIYI@28221|Deltaproteobacteria,2M8GG@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Sodium sulphate symporter	sdcS	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
k59_925253_1	931276.Cspa_c35000	1.9e-21	96.3	COG4974@1|root,COG4974@2|Bacteria,1TR57@1239|Firmicutes,24ACW@186801|Clostridia,36JNY@31979|Clostridiaceae	186801|Clostridia	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_205749_1	395495.Lcho_0343	1.22e-30	111.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2VU6T@28216|Betaproteobacteria,1KM2N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	preprotein translocase	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
k59_205749_2	998674.ATTE01000001_gene2168	3.01e-80	261.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,45ZN8@72273|Thiotrichales	72273|Thiotrichales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_1673998_1	768671.ThimaDRAFT_1995	1.19e-28	106.0	COG4783@1|root,COG4783@2|Bacteria,1N76P@1224|Proteobacteria,1T4CE@1236|Gammaproteobacteria,1X1B8@135613|Chromatiales	135613|Chromatiales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1673998_2	1249627.D779_1371	2.54e-51	174.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales	135613|Chromatiales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_103302_1	1411123.JQNH01000001_gene1343	1.07e-60	197.0	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,2TRC9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TIGRFAM MazG family protein	mazG	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
k59_103302_2	1968.JOEV01000040_gene214	2.06e-15	76.3	COG1127@1|root,COG1127@2|Bacteria,2GJ1T@201174|Actinobacteria	201174|Actinobacteria	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_557403_1	768671.ThimaDRAFT_0763	3.64e-101	297.0	COG1034@1|root,COG1034@2|Bacteria,1QVC7@1224|Proteobacteria	1224|Proteobacteria	C	NADH ubiquinone oxidoreductase	hoxU	-	1.12.1.2	ko:K18006	-	-	-	-	ko00000,ko01000	-	-	-	Fer2_4,Fer4_15,NADH-G_4Fe-4S_3
k59_557403_2	768671.ThimaDRAFT_0762	1.61e-07	52.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1WY5M@135613|Chromatiales	135613|Chromatiales	C	NADH ubiquinone oxidoreductase	-	-	1.17.1.9	ko:K00122	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_278730_1	1336208.JADY01000005_gene1888	7.91e-31	127.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2TUBW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EU	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
k59_1439063_1	1121405.dsmv_3250	9.79e-32	121.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,42NFH@68525|delta/epsilon subdivisions,2WITT@28221|Deltaproteobacteria,2MHQE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_103309_1	83219.PM02_19215	7.88e-83	262.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TQWP@28211|Alphaproteobacteria,3ZWFU@60136|Sulfitobacter	28211|Alphaproteobacteria	E	Gamma-glutamyltranspeptidase	ggt1	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1731397_1	471853.Bcav_1013	4.1e-72	242.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1731397_2	1278308.KB907081_gene2448	1.94e-25	111.0	COG2367@1|root,COG2367@2|Bacteria,2GNRZ@201174|Actinobacteria,4FSGH@85023|Microbacteriaceae	201174|Actinobacteria	V	Beta-lactamase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase2
k59_557405_1	205922.Pfl01_4873	1.93e-24	99.8	COG0782@1|root,COG0782@2|Bacteria,1RHU5@1224|Proteobacteria,1SB59@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Elongation factor	greB2	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB
k59_147177_1	335283.Neut_0167	7.89e-53	167.0	COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,2VVD3@28216|Betaproteobacteria,374NS@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
k59_147177_2	335283.Neut_0168	7.97e-33	115.0	COG3549@1|root,COG3549@2|Bacteria,1MZKX@1224|Proteobacteria,2VUAX@28216|Betaproteobacteria,37490@32003|Nitrosomonadales	28216|Betaproteobacteria	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
k59_278735_1	909663.KI867151_gene3160	9.01e-52	171.0	COG2197@1|root,COG2197@2|Bacteria,1RARA@1224|Proteobacteria,43B1G@68525|delta/epsilon subdivisions,2X5U5@28221|Deltaproteobacteria,2MRK4@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_616014_2	1035308.AQYY01000002_gene646	5.05e-31	112.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
k59_396846_1	698761.RTCIAT899_CH13570	3.25e-37	144.0	COG0022@1|root,COG0332@1|root,COG1071@1|root,COG0022@2|Bacteria,COG0332@2|Bacteria,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2U3XA@28211|Alphaproteobacteria,4B82C@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III,ACP_syn_III_C,Biotin_lipoyl,E1_dh,Transket_pyr,Transketolase_C
k59_1678661_1	1121447.JONL01000003_gene3175	8.59e-60	207.0	COG0457@1|root,COG1413@1|root,COG0457@2|Bacteria,COG1413@2|Bacteria,1MX2U@1224|Proteobacteria,42QJC@68525|delta/epsilon subdivisions,2WPI2@28221|Deltaproteobacteria,2M9VY@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_10,TPR_16,TPR_19,TPR_4,TPR_8
k59_1509685_1	439235.Dalk_4811	5.56e-143	430.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM penicillin-binding protein, 1A family	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
k59_621434_2	1122929.KB908239_gene1399	1.29e-26	108.0	COG0664@1|root,COG0664@2|Bacteria,1PIN3@1224|Proteobacteria,2TSA8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator, Crp Fnr family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
k59_562794_1	1336245.JAGO01000001_gene1090	6.68e-48	165.0	COG0627@1|root,COG0627@2|Bacteria,1N3VN@1224|Proteobacteria,1RYER@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_1873495_1	580332.Slit_1702	3.22e-46	155.0	COG1595@1|root,COG1595@2|Bacteria,1RKQH@1224|Proteobacteria,2VSYG@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1509690_1	1386089.N865_07540	7.84e-81	264.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4FIMQ@85021|Intrasporangiaceae	201174|Actinobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_445646_1	1121013.P873_04775	1.1e-50	172.0	COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,1RS3D@1236|Gammaproteobacteria,1XC2W@135614|Xanthomonadales	135614|Xanthomonadales	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
k59_445646_2	1265502.KB905939_gene2330	1.59e-09	58.5	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2VK0C@28216|Betaproteobacteria,4AAKX@80864|Comamonadaceae	28216|Betaproteobacteria	K	response regulator, receiver	dctR	-	-	ko:K11712	ko02020,map02020	-	-	-	ko00000,ko00001,ko02022	-	-	-	GerE,Response_reg
k59_286414_1	1035308.AQYY01000001_gene3012	9.12e-90	276.0	COG0213@1|root,COG0213@2|Bacteria,1TPCH@1239|Firmicutes,24848@186801|Clostridia,2609M@186807|Peptococcaceae	186801|Clostridia	F	TIGRFAM Pyrimidine-nucleoside phosphorylase	pdp	-	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS08925	Glycos_trans_3N,Glycos_transf_3,PYNP_C
k59_1444510_2	1437882.AZRU01000075_gene4442	9.35e-46	153.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,1RMAE@1236|Gammaproteobacteria,1YF5D@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008690,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019294,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046394,GO:0046400,GO:0046401,GO:0046872,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF1260.b0918,iB21_1397.B21_00929,iBWG_1329.BWG_0770,iECBD_1354.ECBD_2677,iECB_1328.ECB_00922,iECDH10B_1368.ECDH10B_0988,iECDH1ME8569_1439.ECDH1ME8569_0869,iECD_1391.ECD_00922,iETEC_1333.ETEC_0986,iEcDH1_1363.EcDH1_2725,iEcHS_1320.EcHS_A1025,iEcolC_1368.EcolC_2678,iJO1366.b0918,iJR904.b0918,iPC815.YPO1400,iUMNK88_1353.UMNK88_1071,iY75_1357.Y75_RS04770	CTP_transf_3
k59_1275423_1	1122180.Lokhon_02404	7.02e-52	179.0	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2TR5X@28211|Alphaproteobacteria,2P878@245186|Loktanella	28211|Alphaproteobacteria	E	Peptidase family M20/M25/M40	amaB	GO:0003674,GO:0005488,GO:0005515,GO:0042802	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1027517_1	686578.AFFX01000003_gene427	9.98e-100	306.0	COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	COG0464 ATPases of the AAA class	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_286424_2	225849.swp_4029	7.09e-32	120.0	COG1278@1|root,COG1463@1|root,COG1278@2|Bacteria,COG1463@2|Bacteria,1RHH6@1224|Proteobacteria,1S74Q@1236|Gammaproteobacteria,2QBT4@267890|Shewanellaceae	1236|Gammaproteobacteria	Q	Protein of unknown function (DUF3465)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3465
k59_1027522_1	4792.ETI36231	6.03e-54	186.0	COG0486@1|root,KOG1191@2759|Eukaryota,3QEYZ@4776|Peronosporales	4776|Peronosporales	J	MnmE helical domain	-	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_152903_1	1184609.KILIM_008_00080	4.05e-125	375.0	COG3962@1|root,COG3962@2|Bacteria,2GMCJ@201174|Actinobacteria,4F6FD@85018|Dermatophilaceae	201174|Actinobacteria	E	Thiamine pyrophosphate enzyme, central domain	iolD	-	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_739784_1	396588.Tgr7_3165	9.88e-114	340.0	COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,1RQEA@1236|Gammaproteobacteria,1WXT5@135613|Chromatiales	135613|Chromatiales	C	LUD domain	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
k59_1100871_1	396588.Tgr7_3205	1.01e-100	303.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1WWNM@135613|Chromatiales	135613|Chromatiales	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_1873548_1	1123504.JQKD01000032_gene4453	2.66e-18	89.7	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,4AC0C@80864|Comamonadaceae	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_1275441_1	1317122.ATO12_19170	2.66e-10	67.8	COG3291@1|root,COG4932@1|root,COG3291@2|Bacteria,COG4932@2|Bacteria,4NEWJ@976|Bacteroidetes,1HZA6@117743|Flavobacteriia,2YKJX@290174|Aquimarina	976|Bacteroidetes	Q	C-type lectin (CTL) or carbohydrate-recognition domain (CRD)	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,PA14
k59_211305_1	1357272.AVEO02000149_gene1534	4.99e-99	301.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1Z6J0@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	P	Potassium	trkA	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0015075,GO:0015672,GO:0016020,GO:0022857,GO:0030001,GO:0034220,GO:0051179,GO:0051234,GO:0055085,GO:0098655	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	iE2348C_1286.E2348C_3552	TrkA_C,TrkA_N
k59_1100883_1	330214.NIDE3105	1.85e-32	128.0	COG0318@1|root,COG0318@2|Bacteria,3J12Y@40117|Nitrospirae	40117|Nitrospirae	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_1146166_1	1123392.AQWL01000006_gene660	1.08e-18	93.2	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,2VHI3@28216|Betaproteobacteria,1KRBN@119069|Hydrogenophilales	119069|Hydrogenophilales	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_1618796_1	1122963.AUHB01000012_gene1156	1.08e-28	110.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2TQKR@28211|Alphaproteobacteria,36XIQ@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Ribulose-phosphate 3 epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_1027553_1	765912.Thimo_1491	1.34e-77	250.0	COG1269@1|root,COG1269@2|Bacteria,1QGFB@1224|Proteobacteria,1RQRW@1236|Gammaproteobacteria,1WWNC@135613|Chromatiales	135613|Chromatiales	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_1873571_1	1123392.AQWL01000002_gene1767	7.23e-98	296.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VJD9@28216|Betaproteobacteria,1KSZD@119069|Hydrogenophilales	119069|Hydrogenophilales	C	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
k59_445683_1	1442599.JAAN01000035_gene757	1.37e-91	278.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,1RREX@1236|Gammaproteobacteria,1X3WI@135614|Xanthomonadales	135614|Xanthomonadales	C	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_1793415_1	243090.RB5999	1e-43	152.0	COG4974@1|root,COG4974@2|Bacteria,2IX6A@203682|Planctomycetes	203682|Planctomycetes	D	Belongs to the 'phage' integrase family. XerC subfamily	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_993062_1	471853.Bcav_1268	1.94e-23	101.0	COG3595@1|root,COG3595@2|Bacteria,2GKT3@201174|Actinobacteria	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
k59_1509745_1	1045856.EcWSU1_04527	1.31e-74	233.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,3WZUY@547|Enterobacter	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iSSON_1240.SSON_3886,iYL1228.KPN_04138	ATP-synt
k59_1509745_2	519989.ECTPHS_08818	6.05e-305	839.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1WVYR@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_1509745_3	95619.PM1_0229070	1.55e-46	157.0	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iSF_1195.SF3815,iSFxv_1172.SFxv_4157,iS_1188.S3953	OSCP
k59_1509745_4	318161.Sden_3756	6.77e-10	58.2	COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,1S402@1236|Gammaproteobacteria,2QADG@267890|Shewanellaceae	1236|Gammaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031225,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	e_coli_core.b3736,iAF1260.b3736,iB21_1397.B21_03564,iBWG_1329.BWG_3427,iE2348C_1286.E2348C_4046,iEC042_1314.EC042_4123,iEC55989_1330.EC55989_4211,iECABU_c1320.ECABU_c42210,iECBD_1354.ECBD_4296,iECB_1328.ECB_03620,iECDH10B_1368.ECDH10B_3923,iECDH1ME8569_1439.ECDH1ME8569_3624,iECD_1391.ECD_03620,iECED1_1282.ECED1_4426,iECH74115_1262.ECH74115_5172,iECIAI1_1343.ECIAI1_3920,iECIAI39_1322.ECIAI39_4340,iECO103_1326.ECO103_4422,iECO111_1330.ECO111_4570,iECO26_1355.ECO26_4842,iECOK1_1307.ECOK1_4185,iECP_1309.ECP_3935,iECS88_1305.ECS88_4158,iECSE_1348.ECSE_4026,iECSF_1327.ECSF_3584,iECSP_1301.ECSP_4786,iECUMN_1333.ECUMN_4266,iECW_1372.ECW_m4039,iECs_1301.ECs4678,iEKO11_1354.EKO11_4609,iETEC_1333.ETEC_4027,iEcDH1_1363.EcDH1_4231,iEcE24377_1341.EcE24377A_4252,iEcHS_1320.EcHS_A3952,iEcSMS35_1347.EcSMS35_4104,iEcolC_1368.EcolC_4258,iG2583_1286.G2583_4532,iJO1366.b3736,iJR904.b3736,iSDY_1059.SDY_4012,iSFV_1184.SFV_3762,iSF_1195.SF3816,iSFxv_1172.SFxv_4159,iSSON_1240.SSON_3883,iS_1188.S3952,iSbBS512_1146.SbBS512_E4185,iUMN146_1321.UM146_18870,iUMNK88_1353.UMNK88_4548,iUTI89_1310.UTI89_C4291,iWFL_1372.ECW_m4039,iY75_1357.Y75_RS18390,iZ_1308.Z5234,ic_1306.c4664	ATP-synt_B
k59_562872_2	1173020.Cha6605_5608	1.14e-33	127.0	COG0604@1|root,COG0604@2|Bacteria,1G241@1117|Cyanobacteria	1117|Cyanobacteria	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_1100912_1	420662.Mpe_A2747	1.38e-08	55.5	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2VHAQ@28216|Betaproteobacteria,1KJN6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
k59_1100912_2	323848.Nmul_A2509	4.75e-37	137.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,372GX@32003|Nitrosomonadales	28216|Betaproteobacteria	M	TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_1384835_1	768671.ThimaDRAFT_0180	7.2e-99	296.0	COG1226@1|root,2Z7ZD@2|Bacteria,1MXKM@1224|Proteobacteria,1RNMT@1236|Gammaproteobacteria,1WXIM@135613|Chromatiales	135613|Chromatiales	P	PFAM Ion transport	-	-	-	ko:K08714	-	-	-	-	ko00000,ko02000	1.A.1.14	-	-	Ion_trans
k59_993076_1	1218076.BAYB01000024_gene4205	1.45e-33	132.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VHZU@28216|Betaproteobacteria,1K0EZ@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_445700_1	1157708.KB907452_gene3871	3.42e-05	50.1	COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,2VN9T@28216|Betaproteobacteria,4AAVZ@80864|Comamonadaceae	28216|Betaproteobacteria	NU	PFAM Fimbrial assembly family protein	pilN	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
k59_445700_2	472759.Nhal_3889	1.22e-76	235.0	COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1WXKR@135613|Chromatiales	135613|Chromatiales	NU	Pilus assembly protein PilO	-	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
k59_445700_3	935567.JAES01000019_gene1014	2.91e-24	99.4	COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,1S6VJ@1236|Gammaproteobacteria,1X61Y@135614|Xanthomonadales	135614|Xanthomonadales	NU	pilus assembly protein pilp	pilP	-	-	ko:K02665	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilP
k59_211340_1	1384054.N790_14300	5.94e-62	211.0	COG4772@1|root,COG4772@2|Bacteria,1MWDG@1224|Proteobacteria,1RQA5@1236|Gammaproteobacteria,1X5QP@135614|Xanthomonadales	135614|Xanthomonadales	P	receptor	-	-	-	ko:K16091	-	-	-	-	ko00000,ko02000	1.B.14.1.14	-	-	Plug,TonB_dep_Rec
k59_1345382_1	743718.Isova_2325	1.18e-93	286.0	COG1253@1|root,COG1253@2|Bacteria,2GJ8X@201174|Actinobacteria,4F37T@85017|Promicromonosporaceae	201174|Actinobacteria	S	Domain of unknown function DUF21	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
k59_993087_1	1220583.GOACH_12_00550	2.8e-25	105.0	COG0248@1|root,COG0248@2|Bacteria,2GJBN@201174|Actinobacteria,4GB4S@85026|Gordoniaceae	201174|Actinobacteria	FP	Ppx/GppA phosphatase family	ppx2	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_792312_1	1121430.JMLG01000006_gene1801	2.2e-48	176.0	COG1042@1|root,COG1042@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,260BP@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
k59_1679576_1	1123514.KB905899_gene1882	1.75e-24	106.0	COG4733@1|root,COG4733@2|Bacteria,1R55I@1224|Proteobacteria,1S5X2@1236|Gammaproteobacteria,462MH@72273|Thiotrichales	72273|Thiotrichales	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1100924_1	717785.HYPMC_0745	1.06e-79	265.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,3N6A5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Glutamate synthase	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1146207_1	870187.Thini_0589	2.71e-67	217.0	COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,4605G@72273|Thiotrichales	72273|Thiotrichales	M	TIGRFAM lytic murein transglycosylase	-	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	PG_binding_1,SLT_2
k59_504341_1	690850.Desaf_1748	7.21e-61	204.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,42MXS@68525|delta/epsilon subdivisions,2WKEK@28221|Deltaproteobacteria,2M8WD@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Seven times multi-haem cytochrome CxxCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Multi-haem_cyto
k59_856615_1	935839.JAGJ01000022_gene3506	9.7e-100	301.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4F42V@85017|Promicromonosporaceae	201174|Actinobacteria	U	Type II/IV secretion system protein	cpaF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
k59_681228_1	562973.HMPREF0059_01859	9.31e-35	136.0	COG1403@1|root,COG1403@2|Bacteria,2GP2N@201174|Actinobacteria,4D58M@85005|Actinomycetales	201174|Actinobacteria	V	the current gene model (or a revised gene model) may contain a frame shift	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_405570_1	1033802.SSPSH_002858	1.91e-29	115.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c oxidase accessory protein	ccoG	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
k59_405570_2	391008.Smal_1427	1.14e-12	65.1	2EFX9@1|root,339PI@2|Bacteria,1NI0D@1224|Proteobacteria,1SGKH@1236|Gammaproteobacteria,1X8GR@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_792322_1	394221.Mmar10_0249	1.95e-75	246.0	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria,43W98@69657|Hyphomonadaceae	28211|Alphaproteobacteria	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_739850_1	187272.Mlg_0203	1.87e-100	305.0	COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,1S0Z6@1236|Gammaproteobacteria,1WXDJ@135613|Chromatiales	135613|Chromatiales	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_504352_1	1282876.BAOK01000002_gene214	1.41e-21	94.4	COG2834@1|root,COG2834@2|Bacteria,1RA1S@1224|Proteobacteria,2U58W@28211|Alphaproteobacteria,4BQS4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	-	-	-	-	-	-	-	-	-	LolA
k59_856625_1	1384054.N790_06535	9.75e-42	156.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,1RPRP@1236|Gammaproteobacteria,1X56U@135614|Xanthomonadales	135614|Xanthomonadales	S	Penicillin acylase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_405580_1	765911.Thivi_1901	1.4e-66	218.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1WWF8@135613|Chromatiales	135613|Chromatiales	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K01081,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
k59_933876_1	1198232.CYCME_0180	5.62e-73	234.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,46016@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
k59_112075_1	765912.Thimo_0068	4.45e-100	313.0	COG0586@1|root,COG0671@1|root,COG0586@2|Bacteria,COG0671@2|Bacteria,1R0F3@1224|Proteobacteria,1RPDS@1236|Gammaproteobacteria,1WXZF@135613|Chromatiales	135613|Chromatiales	I	PFAM SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	LssY_C,SNARE_assoc
k59_1737006_1	1408224.SAMCCGM7_c2048	2.51e-47	162.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria,4BCFB@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_1737006_2	439496.RBY4I_3671	2.05e-50	169.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_1100958_1	765910.MARPU_02750	4.91e-59	192.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1WWQ1@135613|Chromatiales	135613|Chromatiales	H	Belongs to the ribF family	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
k59_152991_1	754476.Q7A_565	2.15e-117	352.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,45ZW2@72273|Thiotrichales	72273|Thiotrichales	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_1027668_1	566466.NOR53_2445	5.88e-70	229.0	COG0277@1|root,COG0277@2|Bacteria,1N22A@1224|Proteobacteria,1S1MW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
k59_1345442_1	1249627.D779_2413	2.88e-60	201.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1WVVK@135613|Chromatiales	135613|Chromatiales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_53721_1	370438.PTH_2273	1.36e-18	82.0	COG2172@1|root,COG2172@2|Bacteria,1VAPM@1239|Firmicutes,24J9J@186801|Clostridia	186801|Clostridia	T	Histidine kinase-like ATPase domain	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2,STAS_2
k59_53721_2	1307759.JOMJ01000004_gene2845	1.32e-16	76.3	COG0664@1|root,COG0664@2|Bacteria,1RI6M@1224|Proteobacteria,42U8A@68525|delta/epsilon subdivisions,2WPZ6@28221|Deltaproteobacteria,2MCCN@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM Cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_1146915_1	880072.Desac_0445	6.4e-115	343.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2WJT6@28221|Deltaproteobacteria,2MQ97@213462|Syntrophobacterales	68525|delta/epsilon subdivisions	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1619592_1	1380356.JNIK01000014_gene3321	7.9e-127	369.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4ESG3@85013|Frankiales	201174|Actinobacteria	C	CoA-transferase family III	-	-	2.8.3.19	ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_406740_1	1569209.BBPH01000124_gene1871	2.84e-26	107.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2TS3D@28211|Alphaproteobacteria,2PVJ8@265|Paracoccus	28211|Alphaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
k59_994156_1	1123261.AXDW01000001_gene1286	9.62e-21	94.4	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1X69F@135614|Xanthomonadales	135614|Xanthomonadales	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_220328_1	1454010.JEOE01000002_gene466	1.06e-281	803.0	COG1391@1|root,COG1391@2|Bacteria,2GJ91@201174|Actinobacteria,4F0U3@85016|Cellulomonadaceae	201174|Actinobacteria	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_1038179_2	396588.Tgr7_0745	3.59e-184	521.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1WX79@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
k59_571990_2	935839.JAGJ01000030_gene3041	8.14e-53	171.0	COG1490@1|root,COG1490@2|Bacteria,2IKVR@201174|Actinobacteria,4F4IX@85017|Promicromonosporaceae	201174|Actinobacteria	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
k59_454752_1	111781.Lepto7376_3328	2.57e-41	156.0	COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1GBTN@1117|Cyanobacteria,1HH41@1150|Oscillatoriales	2|Bacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S)	-	-	2.7.7.65,2.7.7.7	ko:K02342,ko:K21021	ko00230,ko00240,ko01100,ko02025,ko03030,ko03430,ko03440,map00230,map00240,map01100,map02025,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	CBS,DUF2222,EAL,GAF_2,GGDEF,HAMP,HATPase_c,HisKA_3,PAS,PAS_3,PAS_4,PAS_8,PAS_9,RNase_T,SpoIIE,dCache_1,sCache_3_2
k59_1154465_1	483219.LILAB_17470	9.78e-49	174.0	COG0515@1|root,COG0515@2|Bacteria,1Q38J@1224|Proteobacteria,438ZJ@68525|delta/epsilon subdivisions,2X44T@28221|Deltaproteobacteria,2YY98@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	masK	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_1111753_1	768671.ThimaDRAFT_0815	3.65e-120	360.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,1WXVP@135613|Chromatiales	135613|Chromatiales	P	PFAM von Willebrand factor type A	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_2
k59_162134_1	388051.AUFE01000004_gene939	6.99e-75	249.0	COG0204@1|root,COG0236@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0236@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,1KG5N@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	amp-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,Acyltransferase,PP-binding
k59_1454143_2	1120963.KB894496_gene2676	3.29e-45	155.0	COG3221@1|root,COG3221@2|Bacteria,1R4SK@1224|Proteobacteria,1RR7M@1236|Gammaproteobacteria,2Q0CB@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
k59_1520618_1	1046724.KB889828_gene2913	2.03e-48	166.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,464H0@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
k59_1689075_2	1191523.MROS_2024	5.17e-21	92.0	COG0334@1|root,COG0334@2|Bacteria	2|Bacteria	E	glutamate dehydrogenase [NAD(P)+] activity	gdhA	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_513506_1	857087.Metme_1876	3.91e-154	458.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1XDSN@135618|Methylococcales	135618|Methylococcales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1111757_1	1463854.JOHT01000012_gene4722	2.47e-37	142.0	COG4425@1|root,COG4425@2|Bacteria,2GKB5@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_9,Abhydrolase_9_N
k59_220340_1	398767.Glov_1587	2.59e-06	57.0	COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE2,Pkinase
k59_162142_1	1385517.N800_13450	1.09e-84	259.0	COG0388@1|root,COG0388@2|Bacteria,1MXBR@1224|Proteobacteria,1RQ4Z@1236|Gammaproteobacteria,1X4JY@135614|Xanthomonadales	135614|Xanthomonadales	S	carbon-nitrogen hydrolase	-	-	3.5.1.3	ko:K13566	ko00250,map00250	-	R00269,R00348	RC00010	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
k59_866329_1	1123236.KB899378_gene1784	4.91e-43	147.0	COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,1RPT7@1236|Gammaproteobacteria,4669C@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	SNARE associated Golgi protein	Z012_09465	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_631006_1	258594.RPA4721	7.65e-152	472.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,2U2F7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1393836_1	446462.Amir_4178	8.98e-51	172.0	COG0604@1|root,COG0604@2|Bacteria,2GIWC@201174|Actinobacteria,4E0HT@85010|Pseudonocardiales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
k59_866332_1	76114.ebA6149	2e-18	91.7	COG4206@1|root,COG4206@2|Bacteria,1QUGQ@1224|Proteobacteria,2VIRV@28216|Betaproteobacteria,2KVA3@206389|Rhodocyclales	206389|Rhodocyclales	H	Outer membrane protein beta-barrel family	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_1393838_1	1123367.C666_02840	5.57e-71	221.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2VPZV@28216|Betaproteobacteria,2KU7Q@206389|Rhodocyclales	206389|Rhodocyclales	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
k59_1393838_2	323261.Noc_1020	2.94e-118	348.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1WW9F@135613|Chromatiales	135613|Chromatiales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1746633_1	1134912.AJTV01000053_gene3694	1.02e-38	150.0	COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,2TSQU@28211|Alphaproteobacteria,36ZIN@31993|Methylocystaceae	28211|Alphaproteobacteria	S	von Willebrand factor type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	DUF3520,VWA,vWF_A
k59_162164_1	1123237.Salmuc_00516	5.87e-37	132.0	28KEA@1|root,2ZA0J@2|Bacteria,1R5TS@1224|Proteobacteria,2U48U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Sulfotransferase domain	-	-	2.8.2.1	ko:K01014	ko05204,map05204	-	R01242	RC00007,RC00128	ko00000,ko00001,ko01000	-	-	-	Sulfotransfer_1
k59_1689105_1	1452718.JBOY01000024_gene350	2.91e-173	518.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_1689105_2	318996.AXAZ01000033_gene6458	2.38e-20	94.7	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2TSB6@28211|Alphaproteobacteria,3JR4W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07799,ko:K18990	ko02020,map02020	M00648,M00720	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2.30,8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
k59_631028_1	1316936.K678_04407	4.41e-23	101.0	COG1215@1|root,COG1215@2|Bacteria,1PC79@1224|Proteobacteria,2TU2P@28211|Alphaproteobacteria,2JWE5@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyl transferase family group 2	-	-	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
k59_1038247_1	367299.JOEE01000004_gene1408	3.92e-41	146.0	COG0673@1|root,COG0673@2|Bacteria,2GN2Z@201174|Actinobacteria,4FEGC@85021|Intrasporangiaceae	201174|Actinobacteria	S	oxidoreductase	ydgJ	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_690268_1	1163617.SCD_n01242	1.05e-120	363.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
k59_690275_1	765911.Thivi_3000	2.99e-44	164.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1RQ3H@1236|Gammaproteobacteria,1WW3T@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k59_690276_1	290398.Csal_1428	2.35e-37	135.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria,1XITV@135619|Oceanospirillales	135619|Oceanospirillales	O	DnaJ C terminal domain	cbpA	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
k59_1286647_1	1029824.AFID01000006_gene1246	2.7e-67	213.0	COG0125@1|root,COG0125@2|Bacteria,2GNTI@201174|Actinobacteria,1W963@1268|Micrococcaceae	201174|Actinobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_1,MFS_3,Thymidylate_kin
k59_1286647_2	479433.Caci_8400	5.03e-09	57.8	COG0470@1|root,COG0470@2|Bacteria,2GJ8C@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase III	holB	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
k59_799455_1	545264.KB898750_gene225	6.22e-22	92.0	COG3308@1|root,COG3308@2|Bacteria,1N5UB@1224|Proteobacteria,1SAAJ@1236|Gammaproteobacteria,1X1QR@135613|Chromatiales	135613|Chromatiales	S	Predicted membrane protein (DUF2069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2069
k59_690280_1	1305737.JAFX01000001_gene228	1.59e-60	199.0	COG3288@1|root,COG3288@2|Bacteria,4NGH1@976|Bacteroidetes,47KX8@768503|Cytophagia	976|Bacteroidetes	C	Alanine dehydrogenase/PNT, C-terminal domain	pntAA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_866402_1	1121396.KB892913_gene116	3.02e-43	155.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,42WI2@68525|delta/epsilon subdivisions,2WRPD@28221|Deltaproteobacteria,2MQ18@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Transposase zinc-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_749241_1	1218076.BAYB01000021_gene3766	8.16e-69	221.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2VHG3@28216|Betaproteobacteria,1K1GG@119060|Burkholderiaceae	28216|Betaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_1286657_1	323261.Noc_1406	2.18e-124	388.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,LysM
k59_1286657_2	1122604.JONR01000049_gene732	8.87e-19	85.9	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,1RMR8@1236|Gammaproteobacteria,1X3TE@135614|Xanthomonadales	135614|Xanthomonadales	P	cation diffusion facilitator family transporter	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
k59_1220503_1	999541.bgla_1g30080	7.52e-52	187.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,1K10V@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Belongs to the FtsK SpoIIIE SftA family	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1155832_1	526225.Gobs_3741	4.72e-92	303.0	COG1201@1|root,COG1205@1|root,COG1201@2|Bacteria,COG1205@2|Bacteria,2GKQ2@201174|Actinobacteria,4EU6I@85013|Frankiales	201174|Actinobacteria	L	Domain of unknown function (DUF1998)	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,DUF1998,Helicase_C
k59_1571624_1	713587.THITH_04855	1.92e-42	153.0	COG0845@1|root,COG0845@2|Bacteria,1MWZ9@1224|Proteobacteria,1RM91@1236|Gammaproteobacteria,1WX23@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
k59_1571624_2	156889.Mmc1_3249	1.31e-15	77.0	COG0841@1|root,COG3087@1|root,COG0841@2|Bacteria,COG3087@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1220508_1	706587.Desti_5577	8.47e-110	328.0	COG5659@1|root,COG5659@2|Bacteria,1R1JK@1224|Proteobacteria,4301B@68525|delta/epsilon subdivisions,2WVAD@28221|Deltaproteobacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_1522686_1	446469.Sked_31870	1.57e-52	178.0	COG0226@1|root,COG0226@2|Bacteria,2GJXD@201174|Actinobacteria	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_750861_1	28042.GU90_01805	1.25e-39	144.0	COG0624@1|root,COG0624@2|Bacteria,2I8IJ@201174|Actinobacteria,4E29D@85010|Pseudonocardiales	201174|Actinobacteria	E	Peptidase dimerisation domain	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1395509_1	1123371.ATXH01000026_gene120	6.11e-08	55.1	COG1740@1|root,COG1740@2|Bacteria,2GH25@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	-	-	1.12.2.1,1.12.99.6	ko:K06282,ko:K18008	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
k59_1395509_2	443143.GM18_2849	6.12e-09	59.7	28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,42NZH@68525|delta/epsilon subdivisions,2WKHB@28221|Deltaproteobacteria,43T4R@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Cytochrome c bacterial	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_cB
k59_1040330_1	1386089.N865_04920	7.66e-96	292.0	COG2837@1|root,COG2837@2|Bacteria,2GIUB@201174|Actinobacteria,4FF2J@85021|Intrasporangiaceae	201174|Actinobacteria	P	Dyp-type peroxidase family	efeN	-	-	ko:K16301	-	-	-	-	ko00000,ko01000,ko02000	2.A.108.2.3	-	-	Dyp_perox
k59_340025_1	521393.JH806632_gene917	4.19e-100	304.0	COG0015@1|root,COG0015@2|Bacteria,2GM71@201174|Actinobacteria,4D3SI@85005|Actinomycetales	201174|Actinobacteria	F	adenylosuccinate lyase	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
k59_868165_1	686340.Metal_0818	9.9e-88	275.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1XDT5@135618|Methylococcales	135618|Methylococcales	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_340030_2	1713.JOFV01000010_gene1190	1.82e-60	196.0	COG0101@1|root,COG0101@2|Bacteria,2GJ6C@201174|Actinobacteria,4F0W6@85016|Cellulomonadaceae	201174|Actinobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_691820_1	548479.HMPREF0573_10934	1.44e-34	137.0	2EAB4@1|root,334FC@2|Bacteria,2IRRE@201174|Actinobacteria,4D3GH@85005|Actinomycetales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1220525_1	1122604.JONR01000001_gene1958	3.62e-72	236.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1X4XY@135614|Xanthomonadales	135614|Xanthomonadales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_1629796_3	1049564.TevJSym_ag00550	1.87e-21	86.7	2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SD3Y@1236|Gammaproteobacteria,1J6YA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1571661_1	235985.BBPN01000013_gene6760	1.21e-51	166.0	COG0526@1|root,COG0526@2|Bacteria,2IKP1@201174|Actinobacteria,2NINY@228398|Streptacidiphilus	201174|Actinobacteria	CO	Thioredoxin	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	-	Thioredoxin
k59_1748103_1	2340.JV46_06240	1.35e-06	49.3	COG3001@1|root,COG3001@2|Bacteria,1MVHX@1224|Proteobacteria,1RRC5@1236|Gammaproteobacteria,1J68C@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Fructosamine kinase	yniA	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237	-	-	-	-	-	-	-	-	-	-	Fructosamin_kin
k59_1748103_2	2340.JV46_12010	1.92e-136	394.0	COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,1RN6Q@1236|Gammaproteobacteria,1J5TX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT,Formyl_trans_N
k59_1802837_1	1249627.D779_3387	8.78e-39	139.0	COG1266@1|root,COG1266@2|Bacteria,1R6Z1@1224|Proteobacteria,1RRIS@1236|Gammaproteobacteria,1WWN3@135613|Chromatiales	135613|Chromatiales	S	PFAM CAAX amino terminal protease family	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_1802837_2	95619.PM1_0215930	3.67e-43	151.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0050896,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
k59_1571669_1	203119.Cthe_0089	3.9e-07	56.2	COG1792@1|root,COG1792@2|Bacteria,1TR1V@1239|Firmicutes,249M3@186801|Clostridia,3WIMD@541000|Ruminococcaceae	186801|Clostridia	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
k59_868187_1	377629.TERTU_3830	1.14e-05	47.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,2PMT3@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	J	Ribonuclease E/G family	rng	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_868187_2	42565.FP66_11210	1.51e-60	194.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,1XK3H@135619|Oceanospirillales	135619|Oceanospirillales	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_868187_3	1123279.ATUS01000001_gene2636	2.21e-35	125.0	COG1764@1|root,COG1764@2|Bacteria,1RJIP@1224|Proteobacteria,1S6QM@1236|Gammaproteobacteria,1J9ZC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	redox protein, regulator of disulfide bond formation	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
k59_222084_1	187272.Mlg_2248	1.38e-86	265.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1WW7U@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
k59_750906_1	335543.Sfum_2687	8.63e-152	442.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,42MKE@68525|delta/epsilon subdivisions,2WJF1@28221|Deltaproteobacteria,2MR3P@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	PFAM Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_340055_1	870187.Thini_0272	9.8e-151	443.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,4629A@72273|Thiotrichales	72273|Thiotrichales	P	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
k59_222091_1	644548.SCNU_14551	6.68e-07	54.7	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4GAFM@85026|Gordoniaceae	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_514746_1	228410.NE1277	1.95e-120	369.0	28HUW@1|root,2Z81F@2|Bacteria,1Q3QA@1224|Proteobacteria,2VK1A@28216|Betaproteobacteria,371Y7@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1571696_1	864051.BurJ1DRAFT_1226	3.67e-87	270.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VJ9G@28216|Betaproteobacteria,1KJA8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Trypsin	degQ	-	-	ko:K04691,ko:K04772	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
k59_1690860_1	56780.SYN_00640	9.82e-80	252.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,2MQ50@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_691868_1	95619.PM1_0202825	2.11e-125	384.0	COG1109@1|root,COG4191@1|root,COG1109@2|Bacteria,COG4191@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	phosphomannomutase	algC	GO:0003674,GO:0003824,GO:0004615,GO:0005975,GO:0008150,GO:0008152,GO:0016853,GO:0016866,GO:0016868,GO:0044238,GO:0071704	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1802865_1	1100721.ALKO01000019_gene1331	2.8e-36	140.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,4AAQA@80864|Comamonadaceae	28216|Betaproteobacteria	C	formate dehydrogenase, alpha subunit	fdhA1	-	1.17.1.9,1.17.99.7	ko:K00123,ko:K22015	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1690864_1	323261.Noc_2676	8.25e-84	260.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1WWWV@135613|Chromatiales	135613|Chromatiales	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
k59_163972_2	1303518.CCALI_01175	8.14e-23	89.4	COG0607@1|root,32YCZ@2|Bacteria	2|Bacteria	P	Sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
k59_1643693_1	551115.Aazo_3611	8.46e-07	56.6	COG0526@1|root,COG0526@2|Bacteria,1G5X2@1117|Cyanobacteria,1HKIH@1161|Nostocales	1117|Cyanobacteria	CO	PFAM Thioredoxin	txlA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	-	-	-	-	-	-	-	-	iAPECO1_1312.trxA	Thioredoxin
k59_812813_1	318424.EU78_08785	3.17e-85	265.0	COG4320@1|root,COG4320@2|Bacteria,2GKEK@201174|Actinobacteria,235RE@1762|Mycobacteriaceae	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
k59_1817500_1	1415779.JOMH01000001_gene1128	9.03e-45	157.0	COG0338@1|root,COG0338@2|Bacteria,1QDNB@1224|Proteobacteria,1RXZB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	D12 class N6 adenine-specific DNA methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	MethyltransfD12
k59_586394_2	595460.RRSWK_05100	2.4e-53	183.0	COG2503@1|root,COG2503@2|Bacteria,2J15P@203682|Planctomycetes	203682|Planctomycetes	S	HAD superfamily, subfamily IIIB (Acid phosphatase)	-	-	-	-	-	-	-	-	-	-	-	-	Acid_phosphat_B
k59_526947_1	713587.THITH_01405	3.31e-107	319.0	2BX2I@1|root,2Z9KR@2|Bacteria,1MXKC@1224|Proteobacteria,1RRV2@1236|Gammaproteobacteria,1WXVA@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_526947_2	2340.JV46_07780	7.1e-36	124.0	COG1146@1|root,COG1146@2|Bacteria,1R4GP@1224|Proteobacteria,1RXXW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	reductase beta subunit	aprB	-	1.8.99.2	ko:K00395	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	APS-reductase_C,Fer4,Fer4_9
k59_1817524_1	555779.Dthio_PD0671	8.68e-11	64.7	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2M86E@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_1817524_2	396588.Tgr7_2721	4.79e-25	102.0	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,1RNUY@1236|Gammaproteobacteria,1WW69@135613|Chromatiales	135613|Chromatiales	G	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
k59_586429_1	1300345.LF41_152	2.57e-36	144.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1X3RD@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	rpfC	-	2.7.13.3	ko:K10715	ko02020,ko02024,map02020,map02024	M00517	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Hpt,Response_reg
k59_812894_1	391615.ABSJ01000026_gene121	3.63e-41	148.0	2CIBN@1|root,2Z8JT@2|Bacteria,1R902@1224|Proteobacteria,1RXPM@1236|Gammaproteobacteria,1J8X1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1172058_1	1125725.HMPREF1325_1269	2.45e-61	209.0	COG1155@1|root,COG1155@2|Bacteria,2J5EF@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_526996_1	483219.LILAB_21910	3.29e-57	192.0	COG2801@1|root,COG2801@2|Bacteria,1R6TH@1224|Proteobacteria,42VCD@68525|delta/epsilon subdivisions,2WRUC@28221|Deltaproteobacteria,2YYTF@29|Myxococcales	28221|Deltaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,Mu-transpos_C,rve
k59_812931_1	768671.ThimaDRAFT_0973	4.26e-47	155.0	COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,1S245@1236|Gammaproteobacteria,1WVXE@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
k59_812931_2	765910.MARPU_12345	5.29e-34	125.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,1RMTR@1236|Gammaproteobacteria,1WW49@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_527017_1	314278.NB231_07482	2.24e-147	432.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1WW7H@135613|Chromatiales	135613|Chromatiales	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_586516_1	1131553.JIBI01000046_gene1600	6.15e-173	498.0	COG2855@1|root,COG2855@2|Bacteria	2|Bacteria	P	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
k59_586518_1	443144.GM21_1118	9.26e-15	79.7	COG0467@1|root,COG2202@1|root,COG4251@1|root,COG0467@2|Bacteria,COG2202@2|Bacteria,COG4251@2|Bacteria,1RK1W@1224|Proteobacteria	1224|Proteobacteria	T	MEDS: MEthanogen/methylotroph, DcmR Sensory domain	-	-	-	-	-	-	-	-	-	-	-	-	MEDS
k59_1172107_1	626418.bglu_1g09730	2.12e-80	259.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2VIM4@28216|Betaproteobacteria,1K2QA@119060|Burkholderiaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_812961_2	388051.AUFE01000005_gene1086	0.0005	42.0	COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,2VRXM@28216|Betaproteobacteria,1K7E8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	ybak prolyl-trna synthetase associated region	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
k59_586535_1	292415.Tbd_0161	2.31e-119	350.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2VHJK@28216|Betaproteobacteria,1KS7D@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Phosphoglycerate kinase	-	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_586580_1	880072.Desac_0822	1.33e-44	164.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_1172179_1	1509403.GW12_18730	4.64e-67	216.0	COG4307@1|root,COG4307@2|Bacteria,1MW31@1224|Proteobacteria,1RRA7@1236|Gammaproteobacteria,3NR15@468|Moraxellaceae	1236|Gammaproteobacteria	S	Putative zinc-binding metallo-peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx,zinc-ribbon_6
k59_586615_2	555779.Dthio_PD2497	1.62e-61	193.0	COG1528@1|root,COG1528@2|Bacteria,1R9ZC@1224|Proteobacteria,42S74@68525|delta/epsilon subdivisions,2WNFJ@28221|Deltaproteobacteria,2MBEX@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Iron-storage protein	ftn	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
k59_1817670_1	671143.DAMO_0419	3.08e-80	249.0	COG2234@1|root,COG2234@2|Bacteria,2NQ2F@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M28	yfbL	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
k59_527145_1	1001585.MDS_0329	1.71e-41	155.0	COG3072@1|root,COG3072@2|Bacteria,1PI5T@1224|Proteobacteria,1RMPZ@1236|Gammaproteobacteria,1YDXT@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	F	Adenylate cyclase NT domain	cyaA	GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0052652,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.1	ko:K05851	ko00230,ko02026,ko05111,map00230,map02026,map05111	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_2672,iECOK1_1307.ECOK1_4253,iECS88_1305.ECS88_4229,iUMN146_1321.UM146_19155,iUTI89_1310.UTI89_C4365	Adenyl_cycl_N,Adenylate_cycl
k59_527147_1	187272.Mlg_2233	1.75e-50	171.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1WW9Z@135613|Chromatiales	135613|Chromatiales	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
k59_1817680_1	314262.MED193_09655	2.23e-61	205.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQU2@28211|Alphaproteobacteria,2P4DT@2433|Roseobacter	28211|Alphaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
k59_527151_1	1123257.AUFV01000002_gene2563	5.89e-10	60.5	COG3030@1|root,COG3030@2|Bacteria,1PUFU@1224|Proteobacteria,1T78X@1236|Gammaproteobacteria,1X8YR@135614|Xanthomonadales	135614|Xanthomonadales	S	FxsA cytoplasmic membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	FxsA
k59_813073_1	572546.Arcpr_1251	2.99e-27	110.0	COG0382@1|root,arCOG00477@2157|Archaea,2XW9S@28890|Euryarchaeota,24617@183980|Archaeoglobi	183980|Archaeoglobi	H	4-hydroxybenzoate polyprenyltransferase	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_586704_1	991905.SL003B_1757	1.46e-09	53.9	COG1841@1|root,COG1841@2|Bacteria,1PU2S@1224|Proteobacteria,2UF55@28211|Alphaproteobacteria,4BR4M@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Ribosomal protein L30p/L7e	rpmD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
k59_586704_2	648757.Rvan_2997	7.15e-77	233.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,2TSRI@28211|Alphaproteobacteria,3N6DJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_1817725_1	283699.D172_3385	3.79e-167	504.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q0BY@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_586723_1	935839.JAGJ01000005_gene2566	5.35e-44	158.0	2AR9G@1|root,31GJC@2|Bacteria,2I0KT@201174|Actinobacteria,4F4KM@85017|Promicromonosporaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4192)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4192
k59_527220_1	713586.KB900536_gene1556	2.78e-142	417.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,1WX9B@135613|Chromatiales	135613|Chromatiales	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	-	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Acetyltransf_1
k59_1172305_1	926550.CLDAP_06400	6.62e-107	328.0	COG3383@1|root,COG3383@2|Bacteria,2GBH3@200795|Chloroflexi	200795|Chloroflexi	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_527249_1	713586.KB900536_gene3092	5.49e-51	183.0	COG1629@1|root,COG4771@2|Bacteria,1MX42@1224|Proteobacteria,1RQ2K@1236|Gammaproteobacteria,1WWEW@135613|Chromatiales	135613|Chromatiales	P	TonB-dependent heme hemoglobin receptor	-	-	-	ko:K16087	-	-	-	-	ko00000,ko02000	1.B.14.2	-	-	Plug,TonB_dep_Rec
k59_1817764_1	1188256.BASI01000005_gene2071	2.39e-06	50.4	COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,3FE5Q@34008|Rhodovulum	28211|Alphaproteobacteria	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_1817764_2	935261.JAGL01000002_gene1446	3.68e-51	174.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,43IFB@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_813203_1	325777.GW15_0216835	4.57e-47	163.0	COG0697@1|root,COG0697@2|Bacteria,1MXPW@1224|Proteobacteria,1SB7X@1236|Gammaproteobacteria,1X5BG@135614|Xanthomonadales	135614|Xanthomonadales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_813252_1	1267535.KB906767_gene773	1.89e-166	472.0	COG0524@1|root,COG0524@2|Bacteria,3Y3DE@57723|Acidobacteria,2JI9I@204432|Acidobacteriia	204432|Acidobacteriia	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
k59_586897_1	1294143.H681_14790	3.76e-41	150.0	COG2067@1|root,COG2067@2|Bacteria,1R3SS@1224|Proteobacteria,1S0X2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_586898_1	28444.JODQ01000017_gene6484	3.09e-30	116.0	COG1879@1|root,COG1879@2|Bacteria,2IBMX@201174|Actinobacteria	201174|Actinobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
k59_527378_1	671143.DAMO_0891	6.23e-24	106.0	COG1555@1|root,COG1555@2|Bacteria	2|Bacteria	L	photosystem II stabilization	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
k59_813277_1	1265505.ATUG01000001_gene4358	6.55e-16	77.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,42M37@68525|delta/epsilon subdivisions,2WK30@28221|Deltaproteobacteria,2MNA5@213118|Desulfobacterales	28221|Deltaproteobacteria	G	D-galactarate dehydratase / Altronate hydrolase, C terminus	-	-	4.2.1.7	ko:K16850	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C
k59_813277_2	1449126.JQKL01000004_gene523	1.36e-16	81.3	COG2768@1|root,COG2768@2|Bacteria,1TPRV@1239|Firmicutes,247PJ@186801|Clostridia,26A0J@186813|unclassified Clostridiales	186801|Clostridia	C	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
k59_527382_2	557598.LHK_00283	3.79e-23	100.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria,2KPHC@206351|Neisseriales	206351|Neisseriales	S	cyclopropane-fatty-acyl-phospholipid synthase K00574	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
k59_527392_1	246197.MXAN_1596	4.47e-32	121.0	COG0204@1|root,COG0204@2|Bacteria,1R9IG@1224|Proteobacteria,42T29@68525|delta/epsilon subdivisions,2WPJ8@28221|Deltaproteobacteria,2YU1X@29|Myxococcales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
k59_527392_2	404589.Anae109_3404	1.23e-09	59.3	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2YUPC@29|Myxococcales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	crdA	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_586940_1	187272.Mlg_1684	1.22e-32	121.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,1RRFJ@1236|Gammaproteobacteria,1WWPG@135613|Chromatiales	135613|Chromatiales	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
k59_586940_2	925775.XVE_4093	3.26e-69	217.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,1RP3R@1236|Gammaproteobacteria,1X357@135614|Xanthomonadales	135614|Xanthomonadales	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
k59_586962_1	710696.Intca_0048	3e-218	622.0	COG1651@1|root,COG3004@1|root,COG1651@2|Bacteria,COG3004@2|Bacteria,2GM6C@201174|Actinobacteria,4FFGB@85021|Intrasporangiaceae	201174|Actinobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
k59_527416_1	391625.PPSIR1_37124	2.3e-102	325.0	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	-	-	1.2.3.3	ko:K00158	ko00620,ko01100,map00620,map01100	-	R00207	RC02745	ko00000,ko00001,ko01000	-	-	-	Rieske,TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_527422_1	1411123.JQNH01000001_gene398	6.75e-69	223.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TRJV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	ssdA	-	-	-	-	-	-	-	-	-	-	-	Aldedh
k59_813349_1	42565.FP66_10580	2.82e-17	84.7	COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1XHQX@135619|Oceanospirillales	135619|Oceanospirillales	M	N-acetylmuramoyl-L-alanine amidase	amiB	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,LysM
k59_1817947_1	765911.Thivi_4630	4.32e-96	291.0	COG0420@1|root,COG0420@2|Bacteria,1MXMJ@1224|Proteobacteria,1S1DQ@1236|Gammaproteobacteria,1WXH5@135613|Chromatiales	135613|Chromatiales	L	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_813358_1	1049564.TevJSym_ak00560	1.31e-64	218.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,1J5MJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Ferrous iron transport protein B	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_527468_1	1121405.dsmv_2225	2.73e-61	201.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,42RVN@68525|delta/epsilon subdivisions,2WNJW@28221|Deltaproteobacteria,2MNB1@213118|Desulfobacterales	28221|Deltaproteobacteria	M	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
k59_587032_1	1131553.JIBI01000071_gene2158	4.59e-77	245.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2VIH1@28216|Betaproteobacteria,3720Q@32003|Nitrosomonadales	28216|Betaproteobacteria	C	TrkA-N domain protein	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_1817984_1	1121447.JONL01000003_gene3034	4.9e-79	263.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MG2T@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1817986_1	1123242.JH636434_gene4497	1.24e-43	152.0	COG5659@1|root,COG5659@2|Bacteria	2|Bacteria	L	transposition	insA	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k59_1172614_2	439235.Dalk_5241	1.43e-50	162.0	COG3436@1|root,COG3436@2|Bacteria,1MZFT@1224|Proteobacteria,42URZ@68525|delta/epsilon subdivisions,2WQ58@28221|Deltaproteobacteria,2MKGK@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k59_1172614_3	439235.Dalk_4515	2.25e-66	220.0	COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,43CRI@68525|delta/epsilon subdivisions,2X7Z7@28221|Deltaproteobacteria,2MIWI@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_527523_1	96561.Dole_1510	1.85e-16	84.0	COG0823@1|root,COG0823@2|Bacteria,1NR8W@1224|Proteobacteria,42YPB@68525|delta/epsilon subdivisions,2WTWD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
k59_1818014_1	717785.HYPMC_2892	3.73e-110	336.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2TS97@28211|Alphaproteobacteria,3N680@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NADH-quinone oxidoreductase	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,NADH-G_4Fe-4S_3,NADH_dhqG_C
k59_813441_1	67352.JODS01000008_gene7259	2.71e-47	160.0	COG0113@1|root,COG0113@2|Bacteria,2GJJ0@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the ALAD family	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_1818039_1	1347393.HG726019_gene7723	2.96e-39	144.0	COG0454@1|root,COG0456@2|Bacteria,4NFWE@976|Bacteroidetes,2FNG4@200643|Bacteroidia,4AM1R@815|Bacteroidaceae	976|Bacteroidetes	K	COG NOG07967 non supervised orthologous group	yghO	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1172683_1	1336235.JAEG01000011_gene3032	4.87e-44	156.0	COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2TQXW@28211|Alphaproteobacteria,4B7CD@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	PHB depolymerase	phaZ	-	3.1.1.75	ko:K05973	ko00650,map00650	-	R05118	-	ko00000,ko00001,ko01000	-	-	-	PHB_depo_C
k59_527587_2	439235.Dalk_4738	0.000131	43.1	COG0532@1|root,COG3064@1|root,COG0532@2|Bacteria,COG3064@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2MIGT@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_527610_1	754477.Q7C_2363	1.41e-28	118.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,45ZN8@72273|Thiotrichales	72273|Thiotrichales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_527685_1	1123228.AUIH01000028_gene472	1.33e-26	111.0	COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,1RZ44@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	OmpA MotB	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	OmpA
k59_527701_1	765912.Thimo_1721	1.59e-118	374.0	COG0247@1|root,COG0277@1|root,COG0479@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG0479@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales	135613|Chromatiales	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_813608_1	1415779.JOMH01000001_gene416	0.000235	42.7	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1X3AZ@135614|Xanthomonadales	135614|Xanthomonadales	T	Signal transduction histidine kinase, nitrogen specific	ntrB	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
k59_813608_2	768671.ThimaDRAFT_2574	6.62e-78	247.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WW4B@135613|Chromatiales	135613|Chromatiales	T	response regulator	glnG	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1172874_1	713586.KB900536_gene2316	6.7e-21	92.0	COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,1S739@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
k59_1762271_1	335543.Sfum_2772	1.45e-25	107.0	COG2203@1|root,COG2204@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria	2|Bacteria	T	Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	ko:K02584,ko:K15836,ko:K21009	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Pkinase,Response_reg,Sigma54_activat
k59_1527409_1	1415778.JQMM01000001_gene122	7.9e-39	139.0	COG0546@1|root,COG0546@2|Bacteria,1QUHZ@1224|Proteobacteria,1T1ZN@1236|Gammaproteobacteria,1JC2Z@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_354283_1	318161.Sden_2376	5.06e-22	94.7	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1S66I@1236|Gammaproteobacteria,2QBJI@267890|Shewanellaceae	1236|Gammaproteobacteria	S	ErfK YbiS YcfS YnhG	IV02_27405	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_470812_2	247639.MGP2080_03080	5.91e-25	105.0	COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,1J5SG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_588261_1	1304865.JAGF01000001_gene3889	2.25e-100	302.0	COG1219@1|root,COG1219@2|Bacteria,2GJXQ@201174|Actinobacteria,4F0TW@85016|Cellulomonadaceae	201174|Actinobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_1175344_2	1304275.C41B8_14485	2.95e-87	264.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355	Ubie_methyltran
k59_236253_1	926564.KI911765_gene4570	0.000116	47.8	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4F3VI@85017|Promicromonosporaceae	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1827639_1	765910.MARPU_07900	4.89e-09	55.8	COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,1SAHT@1236|Gammaproteobacteria,1WY27@135613|Chromatiales	135613|Chromatiales	I	PFAM CDP-alcohol phosphatidyltransferase	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_1827639_2	1005058.UMN179_00406	6.43e-18	84.3	COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,1Y838@135625|Pasteurellales	135625|Pasteurellales	L	Belongs to the DnaA family	hda	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:1901360,GO:1901576,GO:2000104,GO:2000112,GO:2000113	-	ko:K10763	-	-	-	-	ko00000,ko03032	-	-	-	Bac_DnaA
k59_888384_1	404589.Anae109_1122	2.93e-14	75.5	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,42M4X@68525|delta/epsilon subdivisions,2WJJY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
k59_181352_1	1458427.BAWN01000032_gene1837	2.37e-81	256.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2VI0N@28216|Betaproteobacteria,4A9T8@80864|Comamonadaceae	28216|Betaproteobacteria	C	TIGRFAM methylmalonate-semialdehyde dehydrogenase	-	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_66602_1	1479238.JQMZ01000001_gene654	4.05e-135	397.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2TSHK@28211|Alphaproteobacteria,43WCG@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1473251_1	477184.KYC_27718	4.53e-40	150.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,3T1UF@506|Alcaligenaceae	28216|Betaproteobacteria	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
k59_1827645_1	1267005.KB911256_gene1780	1.64e-17	84.3	COG3239@1|root,COG3239@2|Bacteria	2|Bacteria	I	unsaturated fatty acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
k59_1707599_1	454957.IA64_10560	3.9e-18	85.1	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1RQ0H@1236|Gammaproteobacteria,1X541@135614|Xanthomonadales	135614|Xanthomonadales	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
k59_709709_1	1179773.BN6_39560	1.16e-56	206.0	COG2372@1|root,COG2372@2|Bacteria,2I4V6@201174|Actinobacteria,4EDR8@85010|Pseudonocardiales	201174|Actinobacteria	DZ	Bacterial Ig-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082
k59_1299535_1	1121875.KB907546_gene2218	7.51e-28	113.0	COG0845@1|root,COG0845@2|Bacteria,4NEXN@976|Bacteroidetes,1HWZ5@117743|Flavobacteriia	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_D23
k59_7438_1	1344012.ATMI01000035_gene2951	2.98e-89	283.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,4BTJB@82986|Tatumella	1236|Gammaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_1238340_1	1120960.ATXG01000020_gene3299	1.2e-31	127.0	COG0433@1|root,COG0433@2|Bacteria,2ICXU@201174|Actinobacteria,4FR0I@85023|Microbacteriaceae	201174|Actinobacteria	S	COG0433 Predicted ATPase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1473281_1	1267533.KB906735_gene4948	9.6e-95	285.0	COG0560@1|root,COG0560@2|Bacteria	2|Bacteria	E	Phosphoserine phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	HAD,His_Phos_2
k59_1414336_1	96561.Dole_0089	3.34e-30	117.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,42NEA@68525|delta/epsilon subdivisions,2WIVS@28221|Deltaproteobacteria,2MHN5@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3198	AA_kinase,PUA
k59_1414336_2	1235755.ANAM01000006_gene2427	1.81e-07	53.9	COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,4H9P8@91061|Bacilli,4GXUQ@90964|Staphylococcaceae	91061|Bacilli	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	GO:0000003,GO:0000160,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0019954,GO:0023052,GO:0030436,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035556,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043934,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
k59_1531325_1	1463825.JNXC01000008_gene1344	5.61e-09	61.2	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DZX5@85010|Pseudonocardiales	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_66632_1	1123073.KB899241_gene1857	1.16e-59	194.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1X3FN@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
k59_298980_1	438753.AZC_3024	1.28e-67	218.0	COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,2TRBC@28211|Alphaproteobacteria,3F1AT@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Beta-lactamase superfamily domain	romA	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_474911_1	686578.AFFX01000003_gene185	3.17e-56	186.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	twitching motility protein	pilU	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_474911_2	472759.Nhal_0207	1.22e-40	141.0	COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,1RQ7W@1236|Gammaproteobacteria,1X286@135613|Chromatiales	135613|Chromatiales	C	Oxidoreductase FAD-binding domain	-	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind
k59_1238353_1	693986.MOC_0622	3.33e-96	288.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,2TSN3@28211|Alphaproteobacteria,1JT0Y@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
k59_1299562_1	1123354.AUDR01000017_gene63	1.52e-73	239.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_1827683_1	1095767.CAHD01000224_gene2103	3.46e-99	304.0	COG0595@1|root,COG0595@2|Bacteria,2GIW7@201174|Actinobacteria,4F0MZ@85016|Cellulomonadaceae	201174|Actinobacteria	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
k59_360118_1	471853.Bcav_3653	4.03e-281	794.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria	201174|Actinobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_826862_1	1249627.D779_2904	1.59e-53	180.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,1WWUF@135613|Chromatiales	135613|Chromatiales	S	PFAM Patatin	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_241381_1	1123258.AQXZ01000014_gene4985	1.72e-55	188.0	COG3845@1|root,COG3845@2|Bacteria,2H7KJ@201174|Actinobacteria,4G9EK@85025|Nocardiaceae	201174|Actinobacteria	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
k59_360123_1	1028806.GGE_0220	4.83e-81	251.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RMN3@1236|Gammaproteobacteria,1Y704@135625|Pasteurellales	135625|Pasteurellales	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_767674_1	983545.Glaag_4002	1.5e-16	84.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RMI7@1236|Gammaproteobacteria,464RZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	mexE	-	-	ko:K18298	-	M00641	-	-	ko00000,ko00002,ko01504,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_415997_1	1089552.KI911559_gene908	1.45e-23	97.4	COG4136@1|root,COG4136@2|Bacteria,1RA88@1224|Proteobacteria,2U67D@28211|Alphaproteobacteria,2JS0J@204441|Rhodospirillales	204441|Rhodospirillales	S	transport system, ATPase component	-	-	-	ko:K05779	-	M00192	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
k59_1002579_2	1123401.JHYQ01000015_gene1412	8.13e-47	154.0	2E0WU@1|root,32VAZ@2|Bacteria,1N42K@1224|Proteobacteria,1S97C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_122666_1	1121918.ARWE01000001_gene3640	2.9e-77	242.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,42NM3@68525|delta/epsilon subdivisions,2WMH9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_1299576_1	1049564.TevJSym_ac01940	5.8e-27	109.0	COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria,1JBWW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	TPR repeat	pilF	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	LysM,TPR_12,TPR_16,TPR_17,TPR_19,TPR_2,TPR_8
k59_947363_1	953739.SVEN_6507	1.84e-18	90.1	COG1216@1|root,COG1216@2|Bacteria,2H44J@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
k59_1531345_1	426114.THI_1055	1.47e-05	53.5	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,1KKB2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Peptidase family M48	yggG_1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
k59_709746_1	1265505.ATUG01000001_gene2897	1.06e-17	80.5	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,42MM6@68525|delta/epsilon subdivisions,2WJ53@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve
k59_360134_1	523791.Kkor_0770	1.37e-83	263.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,1T20X@1236|Gammaproteobacteria,1XH7B@135619|Oceanospirillales	135619|Oceanospirillales	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
k59_592419_1	1267005.KB911257_gene1061	8.21e-39	140.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TTMF@28211|Alphaproteobacteria,3N64T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739,ko:K10764	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_888470_1	335543.Sfum_2433	5.47e-47	172.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42RS1@68525|delta/epsilon subdivisions,2WNR1@28221|Deltaproteobacteria,2MQVG@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
k59_1062482_1	933262.AXAM01000031_gene3014	1.18e-74	243.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2WIPR@28221|Deltaproteobacteria,2MI69@213118|Desulfobacterales	28221|Deltaproteobacteria	D	DNA segregation ATPase, FtsK SpoIIIE family	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_66684_1	1454010.JEOE01000003_gene341	3.07e-21	98.2	COG2141@1|root,COG2141@2|Bacteria,2GJN5@201174|Actinobacteria	201174|Actinobacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_767689_1	765912.Thimo_1549	3.63e-105	315.0	COG0475@1|root,COG0475@2|Bacteria,1MVGV@1224|Proteobacteria,1RQFR@1236|Gammaproteobacteria,1WZGI@135613|Chromatiales	135613|Chromatiales	P	PFAM sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_767689_2	565045.NOR51B_1670	9.36e-79	254.0	COG4325@1|root,COG4325@2|Bacteria,1MXTM@1224|Proteobacteria,1RNYZ@1236|Gammaproteobacteria,1J7K2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Predicted membrane protein (DUF2254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
k59_241442_1	1184607.AUCHE_16_00880	8.04e-139	429.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,2GM5R@201174|Actinobacteria,4F60Z@85018|Dermatophilaceae	201174|Actinobacteria	CE	Proline dehydrogenase	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh
k59_1355403_1	335543.Sfum_0119	8.31e-28	115.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
k59_360164_1	2045.KR76_00895	1.81e-16	83.6	COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4DNHE@85009|Propionibacteriales	201174|Actinobacteria	I	Biotin carboxylase C-terminal domain	accA2	-	6.4.1.1,6.4.1.3,6.4.1.4	ko:K01959,ko:K01965,ko:K01968	ko00020,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01120,ko01130,ko01200,ko01230,map00020,map00280,map00620,map00630,map00640,map00720,map01100,map01120,map01130,map01200,map01230	M00036,M00173,M00373,M00620,M00741	R00344,R01859,R04138	RC00040,RC00097,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0973c	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_360164_2	1122604.JONR01000068_gene4229	1.3e-113	335.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,1RMUX@1236|Gammaproteobacteria,1X3WV@135614|Xanthomonadales	135614|Xanthomonadales	E	Hydroxymethylglutaryl-CoA lyase	mvaB	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
k59_767692_1	589865.DaAHT2_0209	2.39e-34	133.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,43BFP@68525|delta/epsilon subdivisions,2X6U3@28221|Deltaproteobacteria,2MPIH@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Peptidase dimerisation domain	-	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1827745_1	999141.GME_13883	3.35e-23	94.0	COG1815@1|root,COG1815@2|Bacteria,1MZ8P@1224|Proteobacteria,1S9DS@1236|Gammaproteobacteria,1XK50@135619|Oceanospirillales	135619|Oceanospirillales	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	flgB	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
k59_1531372_1	396588.Tgr7_1036	2.64e-108	327.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1WVVJ@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_1827753_1	933262.AXAM01000002_gene547	2.75e-101	309.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WJVC@28221|Deltaproteobacteria,2MINJ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
k59_826918_1	1122134.KB893650_gene1331	2.14e-06	48.5	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,1RNEJ@1236|Gammaproteobacteria,1XPTR@135619|Oceanospirillales	135619|Oceanospirillales	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
k59_826918_2	1502770.JQMG01000001_gene71	1.13e-78	252.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJJS@28216|Betaproteobacteria,2KMJ4@206350|Nitrosomonadales	206350|Nitrosomonadales	I	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_416874_1	1411685.U062_01820	1.04e-16	83.2	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,1S64Q@1236|Gammaproteobacteria,1J69G@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Competence protein	gntX	GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	-	-	-	-	-	-	-	-	-	-	Pribosyltran
k59_9190_1	523791.Kkor_0387	1.58e-92	286.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1XHE8@135619|Oceanospirillales	135619|Oceanospirillales	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.32,1.2.1.60,1.2.1.8,1.2.1.85	ko:K00130,ko:K00151,ko:K10217	ko00260,ko00350,ko00362,ko00380,ko00622,ko01100,ko01120,ko01220,map00260,map00350,map00362,map00380,map00622,map01100,map01120,map01220	M00038,M00533,M00555,M00569	R02565,R02566,R02762,R03889,R04418,R05353	RC00080,RC00218,RC00254	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1650124_1	1049564.TevJSym_ad01440	1.13e-74	234.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1J5KH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_243021_1	572477.Alvin_0345	6.92e-54	171.0	COG2920@1|root,COG2920@2|Bacteria,1RITK@1224|Proteobacteria,1S609@1236|Gammaproteobacteria,1WYM9@135613|Chromatiales	135613|Chromatiales	P	Part of a sulfur-relay system	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_1180173_1	83406.HDN1F_12720	2.56e-13	76.3	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	mmoS	-	-	-	-	-	-	-	-	-	-	-	CHASE5,HATPase_c,HisKA,Hpt,NIT,Response_reg
k59_710618_1	42256.RradSPS_2495	1.77e-86	265.0	COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria,4CPC1@84995|Rubrobacteria	84995|Rubrobacteria	S	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
k59_710618_2	1163617.SCD_n02279	6.3e-10	61.6	COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,Response_reg
k59_1474561_1	479431.Namu_0958	4.41e-37	140.0	COG1263@1|root,COG1264@1|root,COG2190@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,COG2190@2|Bacteria,2GKPM@201174|Actinobacteria	201174|Actinobacteria	G	Phosphotransferase System	nagE	-	2.7.1.193,2.7.1.199	ko:K02778,ko:K02779,ko:K02802,ko:K02803,ko:K02804	ko00010,ko00520,ko02060,ko05111,map00010,map00520,map02060,map05111	M00265,M00267	R02738,R05199	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.1,4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7	-	-	PTS_EIIA_1,PTS_EIIB,PTS_EIIC
k59_1474561_2	31964.CMS0913	3.8e-55	190.0	COG0363@1|root,COG1263@1|root,COG0363@2|Bacteria,COG1263@2|Bacteria,2GK7F@201174|Actinobacteria,4FK5H@85023|Microbacteriaceae	201174|Actinobacteria	G	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion	nagB	-	3.5.99.6	ko:K02564,ko:K02804	ko00520,ko01100,ko02060,map00520,map01100,map02060	M00267	R00765,R05199	RC00017,RC00163,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7	-	-	Glucosamine_iso
k59_1590660_1	1322246.BN4_10650	2.21e-52	178.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,42NP2@68525|delta/epsilon subdivisions,2WIY2@28221|Deltaproteobacteria,2M8N5@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
k59_948635_1	450851.PHZ_c1918	1.08e-35	139.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2TT3G@28211|Alphaproteobacteria,2KFJZ@204458|Caulobacterales	204458|Caulobacterales	P	TonB-dependent Receptor Plug	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
k59_1766855_2	1255043.TVNIR_2584	4.92e-121	350.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,1WW17@135613|Chromatiales	135613|Chromatiales	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_361389_1	880072.Desac_2739	3.9e-51	182.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MQB9@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_534621_1	861299.J421_2780	2.83e-80	245.0	COG0092@1|root,COG0092@2|Bacteria,1ZTFT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_1356273_1	501479.ACNW01000079_gene4564	4e-22	98.2	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2TRVS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.196,3.2.1.68	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02111,R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_416893_1	1265505.ATUG01000002_gene1353	5.24e-43	150.0	COG1024@1|root,COG1024@2|Bacteria,1N5AU@1224|Proteobacteria,42UMD@68525|delta/epsilon subdivisions,2WQDS@28221|Deltaproteobacteria,2MNJN@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_243047_1	749414.SBI_03898	2.62e-50	163.0	COG0262@1|root,COG0262@2|Bacteria,2GKX0@201174|Actinobacteria	201174|Actinobacteria	H	bifunctional deaminase-reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_243047_2	290340.AAur_2013	4.48e-21	86.7	COG3631@1|root,COG3631@2|Bacteria,2IIFS@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
k59_243047_3	1385519.N801_10155	8.45e-30	110.0	COG3631@1|root,COG3631@2|Bacteria,2IIFS@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
k59_652033_2	768671.ThimaDRAFT_3755	2.54e-24	101.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1WWHB@135613|Chromatiales	135613|Chromatiales	E	homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
k59_1590665_1	864051.BurJ1DRAFT_1620	7.12e-70	221.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2VK03@28216|Betaproteobacteria,1KJYT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	TIGRFAM hydrogenase (NiFe) small subunit (hydA)	hoxK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
k59_1590665_2	159087.Daro_3988	1.16e-102	314.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2VJ52@28216|Betaproteobacteria,2KV5T@206389|Rhodocyclales	206389|Rhodocyclales	C	Nickel-dependent hydrogenase	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_827818_1	1298863.AUEP01000002_gene1363	6.59e-20	86.7	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4DQZ1@85009|Propionibacteriales	201174|Actinobacteria	L	Conserved hypothetical protein 95	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
k59_827818_2	351607.Acel_1578	4.47e-55	176.0	COG0669@1|root,COG0669@2|Bacteria,2GN1S@201174|Actinobacteria,4ESMC@85013|Frankiales	201174|Actinobacteria	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_299819_1	398580.Dshi_1709	1.37e-67	221.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,2U3WC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Mechanosensitive ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel
k59_1650140_1	867845.KI911784_gene3392	8.21e-30	117.0	COG1651@1|root,COG1651@2|Bacteria,2G8TG@200795|Chloroflexi,375RW@32061|Chloroflexia	32061|Chloroflexia	O	PFAM DSBA oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
k59_1415337_1	1187851.A33M_0354	9.82e-45	164.0	COG0068@1|root,COG0374@1|root,COG0068@2|Bacteria,COG0374@2|Bacteria,1MVP8@1224|Proteobacteria,2TR2N@28211|Alphaproteobacteria,3FDWE@34008|Rhodovulum	28211|Alphaproteobacteria	O	HypF finger	hypF	-	-	ko:K04653,ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_1474576_1	1123487.KB892835_gene3288	7.59e-85	268.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,2KVW1@206389|Rhodocyclales	206389|Rhodocyclales	JKL	DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_361398_1	644801.Psest_0681	1.59e-121	370.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1Z1G1@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_1063427_1	768671.ThimaDRAFT_3413	5.55e-211	605.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1WWXP@135613|Chromatiales	135613|Chromatiales	J	small GTP-binding protein	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_1120696_1	565045.NOR51B_622	7.76e-47	169.0	COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,1RPD2@1236|Gammaproteobacteria,1J4T5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_16,TPR_19,TPR_20,TPR_8
k59_534636_1	756272.Plabr_2566	1.59e-84	266.0	COG0004@1|root,COG0004@2|Bacteria,2IXR9@203682|Planctomycetes	203682|Planctomycetes	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_1474583_1	335284.Pcryo_0940	2.32e-103	310.0	COG4268@1|root,COG4268@2|Bacteria,1R1FP@1224|Proteobacteria,1RZIR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	DNA restriction-modification system	mcrC	-	-	ko:K19147	-	-	-	-	ko00000,ko02048	-	-	-	McrBC
k59_1474583_2	246195.DNO_0174	5.53e-205	566.0	2C2MI@1|root,2ZBMN@2|Bacteria,1RAX0@1224|Proteobacteria,1S35B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF1837)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1837
k59_652050_1	396588.Tgr7_3063	2.53e-82	270.0	COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,1WWWU@135613|Chromatiales	135613|Chromatiales	C	CoA-binding domain protein	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1481766_1	570967.JMLV01000005_gene127	4.5e-32	131.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2JVNV@204441|Rhodospirillales	204441|Rhodospirillales	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg
k59_955535_1	501479.ACNW01000074_gene1951	3.75e-55	191.0	COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria,2TW3I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0025 NhaP-type Na H and K H antiporters	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
k59_597821_2	768671.ThimaDRAFT_1748	3.39e-158	449.0	COG0650@1|root,COG0650@2|Bacteria,1QE37@1224|Proteobacteria,1RZJC@1236|Gammaproteobacteria,1WWZT@135613|Chromatiales	135613|Chromatiales	C	pfam nadh	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_597821_3	768671.ThimaDRAFT_1747	3.14e-70	231.0	COG0651@1|root,COG0651@2|Bacteria,1RBAF@1224|Proteobacteria,1S3IZ@1236|Gammaproteobacteria,1X24Y@135613|Chromatiales	135613|Chromatiales	CP	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_480638_2	472759.Nhal_0708	1.72e-53	184.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales	135613|Chromatiales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1247853_1	1121017.AUFG01000014_gene2048	3.47e-83	268.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria,4FEVZ@85021|Intrasporangiaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 3 C-terminal domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	F5_F8_type_C,Glyco_hydro_3,Glyco_hydro_3_C
k59_1186522_1	1122165.AUHS01000019_gene1523	1.55e-25	101.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,1S68H@1236|Gammaproteobacteria,1JEJP@118969|Legionellales	118969|Legionellales	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
k59_956678_1	472759.Nhal_2240	2.51e-31	112.0	2E70X@1|root,331JP@2|Bacteria,1N81S@1224|Proteobacteria,1SCI0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
k59_956678_2	1121403.AUCV01000038_gene4230	3.2e-93	279.0	COG0356@1|root,COG0356@2|Bacteria,1RBEV@1224|Proteobacteria	1224|Proteobacteria	C	it plays a direct role in the translocation of protons across the membrane	-	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1308822_1	1408823.AXUS01000008_gene2311	3.12e-09	61.6	COG4299@1|root,COG4299@2|Bacteria,1V3DC@1239|Firmicutes,24FP4@186801|Clostridia,25U4H@186804|Peptostreptococcaceae	186801|Clostridia	S	COGs COG4299 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF5009
k59_305269_1	1410634.JHVD01000001_gene1420	1.51e-128	377.0	COG0174@1|root,COG0174@2|Bacteria,2GMN1@201174|Actinobacteria,4DNAS@85009|Propionibacteriales	201174|Actinobacteria	E	glutamine synthetase	glnA	GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_1247872_1	998674.ATTE01000001_gene2759	7.19e-47	164.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria,460J2@72273|Thiotrichales	72273|Thiotrichales	F	Belongs to the dGTPase family. Type 2 subfamily	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_1247872_2	1042377.AFPJ01000043_gene932	1.08e-60	207.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,46478@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_1186534_1	118163.Ple7327_2077	5.24e-40	138.0	COG4636@1|root,COG4636@2|Bacteria,1GJ6U@1117|Cyanobacteria,3VN6Q@52604|Pleurocapsales	1117|Cyanobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
k59_598605_1	266264.Rmet_0741	2.6e-27	103.0	COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,2VQPG@28216|Betaproteobacteria,1K1V3@119060|Burkholderiaceae	28216|Betaproteobacteria	K	PFAM regulatory protein AsnC Lrp family	lrp	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
k59_481482_1	349124.Hhal_1228	9.3e-15	67.4	COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,1SGDJ@1236|Gammaproteobacteria,1WZNE@135613|Chromatiales	135613|Chromatiales	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
k59_481482_2	1232683.ADIMK_3399	2.83e-10	58.9	COG0594@1|root,COG0594@2|Bacteria,1MZQE@1224|Proteobacteria,1S90M@1236|Gammaproteobacteria,468AM@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031974,GO:0031981,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
k59_1186538_2	1415780.JPOG01000001_gene488	3.35e-65	212.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1X3VI@135614|Xanthomonadales	135614|Xanthomonadales	L	Belongs to the DNA photolyase family	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_305283_1	1121935.AQXX01000111_gene5832	3.49e-107	331.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1XIJU@135619|Oceanospirillales	135619|Oceanospirillales	V	(ABC) transporter	-	-	-	ko:K11004,ko:K13409	ko02010,ko03070,ko04626,ko05133,map02010,map03070,map04626,map05133	M00325,M00339,M00575	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.1,3.A.1.109.2,3.A.1.110	-	-	ABC_membrane,ABC_tran,Peptidase_C39
k59_956712_1	314345.SPV1_03033	1.49e-62	200.0	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria	1224|Proteobacteria	T	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
k59_1008100_1	754476.Q7A_1422	2.04e-38	144.0	COG0382@1|root,COG0560@1|root,COG0382@2|Bacteria,COG0560@2|Bacteria,1MXCM@1224|Proteobacteria,1RRWB@1236|Gammaproteobacteria,46214@72273|Thiotrichales	72273|Thiotrichales	H	UbiA prenyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	HAD,UbiA
k59_1308851_1	590998.Celf_2148	7.42e-76	230.0	COG0756@1|root,COG0756@2|Bacteria,2IHYY@201174|Actinobacteria,4F17S@85016|Cellulomonadaceae	201174|Actinobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
k59_369463_1	765913.ThidrDRAFT_1660	4.18e-27	112.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1WXNX@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
k59_254003_2	911239.CF149_18826	2.17e-43	149.0	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	cytochrome	cc4	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_1308857_1	309807.SRU_0756	3.96e-110	330.0	COG0502@1|root,COG0502@2|Bacteria,4NEMA@976|Bacteroidetes,1FJYV@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
k59_305294_1	1211777.BN77_1390	3.63e-05	45.4	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,4B8XK@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	polyphosphate kinase activity	ppk_2	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008976,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0042802,GO:0044237	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
k59_75945_2	234267.Acid_5112	1.31e-69	222.0	COG0092@1|root,COG0092@2|Bacteria,3Y3ZN@57723|Acidobacteria	57723|Acidobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_1537870_1	439235.Dalk_1330	1.03e-66	215.0	COG3464@1|root,COG3464@2|Bacteria,1PFY7@1224|Proteobacteria,4377W@68525|delta/epsilon subdivisions,2X29U@28221|Deltaproteobacteria,2MP93@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Helix-turn-helix domain of transposase family ISL3	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3
k59_716719_1	935839.JAGJ01000011_gene410	3.44e-60	200.0	COG3307@1|root,COG3307@2|Bacteria,2I8W0@201174|Actinobacteria	201174|Actinobacteria	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
k59_1482982_1	999141.GME_06295	6.27e-53	182.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1XH5E@135619|Oceanospirillales	135619|Oceanospirillales	C	2-oxoglutarate dehydrogenase complex	lpdG	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_75953_2	102125.Xen7305DRAFT_00027360	5.59e-08	54.3	COG1361@1|root,COG4409@1|root,COG1361@2|Bacteria,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,CelD_N,DUF11,Glyco_hydro_9
k59_1308870_1	497321.C664_10148	5.03e-78	244.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,2VIYE@28216|Betaproteobacteria,2KUH2@206389|Rhodocyclales	206389|Rhodocyclales	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_188477_1	767434.Fraau_0408	7.94e-91	280.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,1X32N@135614|Xanthomonadales	135614|Xanthomonadales	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_1421547_1	85643.Tmz1t_3962	1.24e-129	383.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VH51@28216|Betaproteobacteria,2KVTM@206389|Rhodocyclales	206389|Rhodocyclales	O	Collagenase and related proteases	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
k59_1537878_1	1234364.AMSF01000005_gene808	1.39e-14	73.2	COG4319@1|root,COG4319@2|Bacteria,1N361@1224|Proteobacteria,1S9P8@1236|Gammaproteobacteria,1X7TS@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_2,SnoaL_3
k59_75961_1	1249627.D779_0891	1.06e-105	318.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1WW6C@135613|Chromatiales	135613|Chromatiales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_1072628_1	1386089.N865_20775	3.7e-120	354.0	COG0206@1|root,COG0206@2|Bacteria,2GJWC@201174|Actinobacteria,4FE51@85021|Intrasporangiaceae	201174|Actinobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_540365_1	933262.AXAM01000002_gene498	2.67e-57	194.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42RC9@68525|delta/epsilon subdivisions,2WN5U@28221|Deltaproteobacteria,2MJV9@213118|Desulfobacterales	28221|Deltaproteobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF4388,PEGA,Pkinase
k59_1072637_1	1095769.CAHF01000014_gene3011	2.22e-107	322.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2VH57@28216|Betaproteobacteria,472FH@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_1772362_1	1121405.dsmv_0970	3.94e-88	276.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MAV@68525|delta/epsilon subdivisions,2WJC9@28221|Deltaproteobacteria,2MIPJ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	cimA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1837127_1	768671.ThimaDRAFT_2292	3.03e-33	129.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,1S4M3@1236|Gammaproteobacteria,1WWN6@135613|Chromatiales	135613|Chromatiales	E	Extracellular solute-binding protein, family 5	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
k59_1837127_2	314278.NB231_16698	3.79e-161	458.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1WXAY@135613|Chromatiales	135613|Chromatiales	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1008133_1	1538295.JY96_20310	1.08e-05	46.6	COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,2VNH6@28216|Betaproteobacteria,1KMUX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051,ko:K15553	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	NMT1
k59_1008133_2	396588.Tgr7_3082	2.99e-92	279.0	COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,1RQPA@1236|Gammaproteobacteria,1X2CQ@135613|Chromatiales	135613|Chromatiales	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_1837132_1	1049564.TevJSym_am00160	5.76e-35	136.0	COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,1RSJC@1236|Gammaproteobacteria,1J9QI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_1537899_1	446471.Xcel_0845	1.68e-49	172.0	2DVVA@1|root,32V07@2|Bacteria,2IHH0@201174|Actinobacteria,4F5R6@85017|Promicromonosporaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1008135_1	290397.Adeh_4084	1.19e-40	146.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,42PGW@68525|delta/epsilon subdivisions,2WMMZ@28221|Deltaproteobacteria,2YUHA@29|Myxococcales	28221|Deltaproteobacteria	C	NAD(P)H quinone oxidoreductase, PIG3 family	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_129810_1	1123366.TH3_07932	3.37e-61	201.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2TTS5@28211|Alphaproteobacteria,2JRCB@204441|Rhodospirillales	204441|Rhodospirillales	S	Elongator protein 3, MiaB family, Radical SAM	pqqE	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_1308906_1	1121403.AUCV01000065_gene4169	3.11e-38	139.0	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria	2|Bacteria	P	iron ion homeostasis	feoA	-	-	ko:K03322,ko:K03709,ko:K04758	-	-	-	-	ko00000,ko02000,ko03000	2.A.55.2.6,2.A.55.3	-	-	Fe_dep_repr_C,FeoA
k59_75985_1	314287.GB2207_01907	1.14e-17	88.2	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria,1RMQA@1236|Gammaproteobacteria,1J8I5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_540377_1	383372.Rcas_3656	1.54e-107	322.0	COG0451@1|root,COG0451@2|Bacteria,2G7TT@200795|Chloroflexi	200795|Chloroflexi	M	Male sterility protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
k59_1483031_1	1038869.AXAN01000259_gene2194	1.21e-98	291.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria,1K21K@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA polymerase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_254066_1	1262449.CP6013_0475	6.46e-26	108.0	COG1835@1|root,COG1835@2|Bacteria,1V7CG@1239|Firmicutes,24WKR@186801|Clostridia	186801|Clostridia	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_188512_1	1040983.AXAE01000035_gene2354	1.45e-18	87.8	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43JWG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16,TPR_19,TPR_2
k59_1837149_1	999141.GME_10186	8.48e-140	417.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1XIN2@135619|Oceanospirillales	135619|Oceanospirillales	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_1483037_2	1144307.PMI04_02525	7.43e-47	159.0	2DNBN@1|root,32WN2@2|Bacteria,1N5BF@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
k59_20507_1	935567.JAES01000001_gene2174	1.55e-54	186.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1X4NW@135614|Xanthomonadales	135614|Xanthomonadales	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_1483038_1	1408437.JNJN01000002_gene1425	3.39e-37	137.0	COG0715@1|root,COG0715@2|Bacteria,1TT2F@1239|Firmicutes,249M2@186801|Clostridia,25WBT@186806|Eubacteriaceae	186801|Clostridia	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2,Phosphonate-bd,VitK2_biosynth
k59_897795_1	101510.RHA1_ro05722	3.28e-52	172.0	COG5587@1|root,COG5587@2|Bacteria,2IJG5@201174|Actinobacteria,4FVR0@85025|Nocardiaceae	201174|Actinobacteria	S	Conserved hypothetical protein (DUF2461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
k59_598668_1	631362.Thi970DRAFT_02800	7.08e-59	199.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales	135613|Chromatiales	I	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_1656362_1	1237149.C900_01127	1.53e-33	122.0	COG2062@1|root,COG2062@2|Bacteria,4NQFM@976|Bacteroidetes,47R7I@768503|Cytophagia	976|Bacteroidetes	T	PFAM Phosphoglycerate mutase	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
k59_1421591_1	1316927.ATKI01000141_gene1922	5.77e-28	117.0	28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,1RN0X@1236|Gammaproteobacteria,1YMYP@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	M	Fatty acid cis/trans isomerase (CTI)	cti	-	-	-	-	-	-	-	-	-	-	-	CTI
k59_1008157_1	1121422.AUMW01000026_gene388	3.01e-76	239.0	COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,260SY@186807|Peptococcaceae	186801|Clostridia	C	ferredoxin oxidoreductase	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_956809_1	998088.B565_2361	3.59e-153	470.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1Y3MV@135624|Aeromonadales	135624|Aeromonadales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_369553_1	1049564.TevJSym_aa01830	1.25e-62	209.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1SNU0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_598673_1	1195246.AGRI_05487	1.69e-157	476.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464AK@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1537930_1	222534.KB893721_gene918	1.26e-31	127.0	COG1944@1|root,COG1944@2|Bacteria,2GKBS@201174|Actinobacteria	201174|Actinobacteria	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
k59_1361966_1	1184609.KILIM_008_00080	1.15e-95	297.0	COG3962@1|root,COG3962@2|Bacteria,2GMCJ@201174|Actinobacteria,4F6FD@85018|Dermatophilaceae	201174|Actinobacteria	E	Thiamine pyrophosphate enzyme, central domain	iolD	-	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1255068_1	593907.Celgi_0368	1.31e-94	293.0	COG0029@1|root,COG0029@2|Bacteria,2I2IJ@201174|Actinobacteria,4F13T@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16,2.4.2.19	ko:K00278,ko:K00767	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481,R03348	RC00006,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1844903_1	519989.ECTPHS_05556	5.26e-22	95.5	COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria,1WXRX@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins	zipA	-	-	ko:K03528	-	-	-	-	ko00000,ko03036	-	-	-	ZipA_C
k59_663626_1	1267005.KB911262_gene3352	4.13e-18	79.0	2C39R@1|root,32UYY@2|Bacteria,1N8ND@1224|Proteobacteria,2UFIK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_964534_1	883066.HMPREF9233_01156	5.56e-89	278.0	COG3266@1|root,COG3266@2|Bacteria,2I44K@201174|Actinobacteria,4D583@85005|Actinomycetales	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1012719_1	2340.JV46_28190	7.1e-27	102.0	2AAM4@1|root,30ZYM@2|Bacteria,1RFTG@1224|Proteobacteria,1S4UQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2384
k59_1601686_2	314278.NB231_13571	2.48e-69	214.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,1RP1N@1236|Gammaproteobacteria,1WWRQ@135613|Chromatiales	135613|Chromatiales	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_1719430_1	1278309.KB907103_gene1061	8.98e-26	103.0	COG2143@1|root,COG2143@2|Bacteria,1NP6X@1224|Proteobacteria,1SBRN@1236|Gammaproteobacteria,1XKIM@135619|Oceanospirillales	135619|Oceanospirillales	O	Thioredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
k59_1662039_1	324925.Ppha_1748	4.22e-40	142.0	COG0451@1|root,COG0451@2|Bacteria,1FDWT@1090|Chlorobi	1090|Chlorobi	M	short-chain dehydrogenase reductase SDR	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase
k59_722187_1	1163617.SCD_n02012	2.5e-64	213.0	COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,2VNGV@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_261690_1	1297742.A176_01238	1.05e-87	278.0	COG1164@1|root,COG1164@2|Bacteria,1MWYN@1224|Proteobacteria,437WG@68525|delta/epsilon subdivisions,2X364@28221|Deltaproteobacteria,2YUG4@29|Myxococcales	28221|Deltaproteobacteria	E	Angiotensin-converting enzyme	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
k59_486981_1	94122.Shewana3_0594	1.27e-08	57.4	COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,2QA31@267890|Shewanellaceae	1236|Gammaproteobacteria	M	cell wall hydrolase autolysin	amiB	GO:0000003,GO:0000910,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0008745,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019954,GO:0022402,GO:0022414,GO:0030288,GO:0030313,GO:0031975,GO:0032505,GO:0042597,GO:0043093,GO:0044464,GO:0051301,GO:0061783	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	iG2583_1286.G2583_4996	AMIN,Amidase_3,LysM
k59_486981_2	384676.PSEEN4947	1.72e-29	110.0	COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,1S6IB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ATPase or kinase	yjeE	GO:0000166,GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043531,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
k59_1367559_1	1187848.AJYQ01000039_gene3414	1.11e-08	63.9	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1THIN@1236|Gammaproteobacteria,1XW5G@135623|Vibrionales	135623|Vibrionales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,dCache_1
k59_83757_1	2340.JV46_05270	1.07e-49	163.0	COG2863@1|root,COG2863@2|Bacteria,1R8K9@1224|Proteobacteria,1S1Q4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	PFAM Cytochrome C	fccA	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K17230	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_83757_2	765910.MARPU_11175	1.73e-63	208.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria,1WXS3@135613|Chromatiales	135613|Chromatiales	S	Flavocytochrome c sulphide dehydrogenase, flavin-binding	-	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.8.2.3	ko:K17229	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2,TAT_signal
k59_964557_2	399739.Pmen_1835	3.11e-64	202.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1RNU8@1236|Gammaproteobacteria,1YDT7@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	J	Belongs to the SUA5 family	yciO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
k59_377330_1	1283300.ATXB01000002_gene3052	0.000129	45.1	COG4262@1|root,COG4262@2|Bacteria,1QUPY@1224|Proteobacteria,1RMJV@1236|Gammaproteobacteria,1XFY9@135618|Methylococcales	135618|Methylococcales	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
k59_377330_2	401053.AciPR4_3360	5.05e-84	265.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
k59_604153_1	292415.Tbd_0991	5.14e-58	189.0	COG0596@1|root,COG0596@2|Bacteria,1RJQK@1224|Proteobacteria,2W4YC@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_604153_2	1049564.TevJSym_ao00540	9.73e-70	216.0	COG1011@1|root,COG1011@2|Bacteria,1NH15@1224|Proteobacteria,1RP27@1236|Gammaproteobacteria,1J5ZA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	hydrolase (HAD superfamily)	yrfG	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008477,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016798,GO:0016799,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050483,GO:0050484	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
k59_1427158_2	883126.HMPREF9710_04313	1.95e-37	142.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,473Z1@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_964562_1	765911.Thivi_0758	4.61e-05	44.7	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1WW9D@135613|Chromatiales	135613|Chromatiales	L	single-stranded-DNA-specific exonuclease RecJ	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_964562_2	396595.TK90_0982	2.53e-156	447.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,1WWPU@135613|Chromatiales	135613|Chromatiales	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_27802_2	1496688.ER33_02795	1.11e-49	167.0	COG2326@1|root,COG2326@2|Bacteria,1G159@1117|Cyanobacteria,22TKN@167375|Cyanobium	1117|Cyanobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_428228_1	105422.BBPM01000002_gene4956	2.2e-31	117.0	COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,2NEBS@228398|Streptacidiphilus	201174|Actinobacteria	J	RimM N-terminal domain	rimM	GO:0008150,GO:0040007	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
k59_428228_2	479431.Namu_3133	1.71e-17	79.0	COG0336@1|root,COG0336@2|Bacteria,2GJ1G@201174|Actinobacteria,4ERT5@85013|Frankiales	201174|Actinobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Acetyltransf_1,tRNA_m1G_MT
k59_722205_1	1304865.JAGF01000001_gene1361	3.62e-102	308.0	COG0276@1|root,COG0276@2|Bacteria,2GJTQ@201174|Actinobacteria,4F12R@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
k59_722205_2	1304865.JAGF01000001_gene1362	1.32e-96	289.0	COG3253@1|root,COG3253@2|Bacteria,2GK24@201174|Actinobacteria,4F0VC@85016|Cellulomonadaceae	201174|Actinobacteria	S	Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
k59_722205_3	1304865.JAGF01000001_gene1363	7.42e-20	93.6	COG1232@1|root,COG1232@2|Bacteria,2GMMA@201174|Actinobacteria,4F0Z0@85016|Cellulomonadaceae	201174|Actinobacteria	H	Flavin containing amine oxidoreductase	hemG	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_1719475_1	497321.C664_04097	3.65e-51	177.0	COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,2VICB@28216|Betaproteobacteria	28216|Betaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrA	-	1.6.5.8	ko:K00346	-	-	-	-	ko00000,ko01000	-	-	-	NQRA,NQRA_SLBB
k59_1130536_1	314285.KT71_17271	1.86e-39	146.0	COG1404@1|root,COG1404@2|Bacteria,1PE2Y@1224|Proteobacteria,1SQ8B@1236|Gammaproteobacteria,1JBCF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_1130536_2	997346.HMPREF9374_1497	2.08e-42	145.0	COG0204@1|root,COG0204@2|Bacteria,1UGYE@1239|Firmicutes,4HFMM@91061|Bacilli,27CMG@186824|Thermoactinomycetaceae	91061|Bacilli	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
k59_1255138_1	290318.Cvib_0146	1.64e-05	44.7	COG5501@1|root,COG5501@2|Bacteria,1FFAE@1090|Chlorobi	1090|Chlorobi	S	Sulphur oxidation protein SoxZ	-	-	-	ko:K17227	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxZ
k59_1255138_2	1328313.DS2_11448	8.27e-14	73.2	COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,1RQWX@1236|Gammaproteobacteria,466VV@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	glycerophosphoryl diester phosphodiesterase	ugpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_905615_1	713586.KB900536_gene2963	1.56e-52	179.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1WVUR@135613|Chromatiales	135613|Chromatiales	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
k59_1427181_1	765912.Thimo_1968	7.48e-143	420.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1WW0Z@135613|Chromatiales	135613|Chromatiales	CI	TIGRFAM Oxaloacetate decarboxylase, alpha subunit	-	-	6.4.1.1	ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_1844986_1	713587.THITH_13800	3.36e-57	188.0	COG2133@1|root,COG2133@2|Bacteria,1R65J@1224|Proteobacteria,1RYQV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Large extracellular alpha-helical protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_604176_1	1249627.D779_3541	2.43e-69	219.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria,1WXJX@135613|Chromatiales	135613|Chromatiales	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
k59_604176_2	765913.ThidrDRAFT_2978	1.24e-15	75.5	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,1RQ50@1236|Gammaproteobacteria,1WWA9@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD dependent oxidoreductase	-	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
k59_777788_1	471853.Bcav_3816	3.17e-103	314.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria	201174|Actinobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	mrpD	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_1543483_1	1123065.ATWL01000002_gene1464	5.68e-275	767.0	COG1061@1|root,COG1061@2|Bacteria,2GIU5@201174|Actinobacteria	201174|Actinobacteria	L	type III restriction enzyme, res subunit	sdrA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ResIII
k59_1427182_1	590998.Celf_2191	7.51e-43	151.0	COG1104@1|root,COG1104@2|Bacteria,2GJ2B@201174|Actinobacteria,4F0GP@85016|Cellulomonadaceae	201174|Actinobacteria	E	Aminotransferase class-V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5,TusA
k59_1012768_1	164328.Phyra77718	1.51e-40	149.0	COG3491@1|root,KOG0143@2759|Eukaryota,3QADR@4776|Peronosporales	2759|Eukaryota	Q	Belongs to the iron ascorbate-dependent oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy,DIOX_N
k59_1012768_2	1121939.L861_01760	4e-16	74.7	COG2128@1|root,COG2128@2|Bacteria,1NDTM@1224|Proteobacteria	1224|Proteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_839468_1	1049564.TevJSym_ar00500	1.47e-35	129.0	28NN8@1|root,2ZBNM@2|Bacteria,1RC04@1224|Proteobacteria,1S2KF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_311002_1	768671.ThimaDRAFT_3631	9.36e-93	293.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,1RMBV@1236|Gammaproteobacteria,1WW88@135613|Chromatiales	135613|Chromatiales	M	TIGRFAM Penicillin-binding protein 1C	-	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
k59_1081123_1	391593.RCCS2_01523	8.45e-40	145.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,2P2KB@2433|Roseobacter	28211|Alphaproteobacteria	Q	COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1081123_2	491952.Mar181_3511	8.05e-39	141.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1XH97@135619|Oceanospirillales	135619|Oceanospirillales	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_27859_1	742738.HMPREF9460_02911	3.21e-35	137.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,267PD@186813|unclassified Clostridiales	186801|Clostridia	P	Heavy-metal-associated domain	actP	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_1662099_1	545264.KB898747_gene587	6.58e-106	321.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	zraR	GO:0000156,GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0023052,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035556,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1845010_1	926559.JoomaDRAFT_3738	2.91e-15	80.9	COG1757@1|root,COG1757@2|Bacteria,4NFQT@976|Bacteroidetes,1HWVE@117743|Flavobacteriia	976|Bacteroidetes	C	Na H antiporter	nhaC	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
k59_261773_1	357804.Ping_3632	7.34e-17	77.4	COG2391@1|root,COG2391@2|Bacteria,1MZ3A@1224|Proteobacteria,1S95T@1236|Gammaproteobacteria,2QIAS@267894|Psychromonadaceae	1236|Gammaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_261773_2	1173029.JH980292_gene3302	7.31e-42	142.0	COG2391@1|root,COG2391@2|Bacteria,1G7H1@1117|Cyanobacteria,1HBX6@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM YeeE YedE family (DUF395)	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_839475_1	1163617.SCD_n02230	6.31e-47	172.0	COG5492@1|root,COG5492@2|Bacteria,1QY8X@1224|Proteobacteria,2VJ6A@28216|Betaproteobacteria	28216|Betaproteobacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1602489_1	1304865.JAGF01000001_gene1581	2.12e-116	339.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,4F1V0@85016|Cellulomonadaceae	201174|Actinobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_136234_2	519989.ECTPHS_01834	3.95e-44	154.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1WX5B@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_664476_1	1123368.AUIS01000036_gene86	3.86e-12	66.6	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,2NC08@225057|Acidithiobacillales	225057|Acidithiobacillales	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
k59_664476_2	765912.Thimo_2609	5.6e-06	51.2	COG3909@1|root,COG3909@2|Bacteria,1PCBH@1224|Proteobacteria,1S78Q@1236|Gammaproteobacteria,1WY7M@135613|Chromatiales	135613|Chromatiales	C	PFAM Cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_2
k59_1192983_1	471857.Svir_39250	1.62e-49	172.0	COG2837@1|root,COG2837@2|Bacteria,2GIUB@201174|Actinobacteria,4DXQP@85010|Pseudonocardiales	201174|Actinobacteria	P	PFAM Dyp-type peroxidase	-	-	1.11.1.19	ko:K15733	-	-	-	-	ko00000,ko01000	-	-	-	Dyp_perox
k59_605005_1	706191.PANA_0256	3.3e-84	257.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria,3VXXS@53335|Pantoea	1236|Gammaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_605005_2	187272.Mlg_1095	2.91e-36	132.0	COG4544@1|root,COG4544@2|Bacteria,1MZQU@1224|Proteobacteria,1S9RP@1236|Gammaproteobacteria,1WZQP@135613|Chromatiales	135613|Chromatiales	D	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division	-	-	-	ko:K14160	-	-	-	-	ko00000,ko03400	-	-	-	SulA
k59_722914_1	572477.Alvin_0015	8.07e-91	295.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1WX2G@135613|Chromatiales	135613|Chromatiales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
k59_1490931_1	314345.SPV1_13387	4.88e-58	190.0	COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria	1224|Proteobacteria	S	Bile acid sodium symporter	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
k59_1082168_1	382464.ABSI01000017_gene53	1.09e-56	199.0	COG0457@1|root,COG0457@2|Bacteria,46U2J@74201|Verrucomicrobia,2IV5B@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Domain of unknown function (DUF5107)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5107,TPR_8
k59_1317908_1	1502770.JQMG01000001_gene1467	1.98e-22	98.6	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,2KKPJ@206350|Nitrosomonadales	206350|Nitrosomonadales	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_136247_1	1120956.JHZK01000007_gene2861	1.97e-97	295.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2TQKT@28211|Alphaproteobacteria,1JN1X@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_722922_1	1056512.D515_01159	8.61e-113	338.0	COG0786@1|root,COG0786@2|Bacteria,1MVBC@1224|Proteobacteria,1RP0S@1236|Gammaproteobacteria,1XUE5@135623|Vibrionales	135623|Vibrionales	P	Catalyzes the sodium-dependent transport of glutamate	gltS	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
k59_194840_1	1123355.JHYO01000018_gene1664	8.52e-77	253.0	COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,2TTSC@28211|Alphaproteobacteria,36XM4@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Tex-like protein N-terminal domain	tex	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
k59_378472_2	1286106.MPL1_06507	6.21e-120	348.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RM9H@1236|Gammaproteobacteria,460AA@72273|Thiotrichales	72273|Thiotrichales	Q	ABC transporter permease	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_1662927_1	765910.MARPU_10595	2.49e-101	327.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1WX8F@135613|Chromatiales	135613|Chromatiales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_1368440_1	880072.Desac_2729	1.49e-33	127.0	COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,42M60@68525|delta/epsilon subdivisions,2WITJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	dsrK	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_1368440_2	880072.Desac_2730	1.83e-31	119.0	COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,42MZU@68525|delta/epsilon subdivisions,2WKKU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Nitrate reductase gamma subunit	dsrM	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
k59_605024_1	1049564.TevJSym_ad01660	8.74e-62	209.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1J4J1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Cytochrome c-type biogenesis protein	ccmF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_605024_2	1288494.EBAPG3_12760	2.1e-47	157.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2VR8D@28216|Betaproteobacteria,372UU@32003|Nitrosomonadales	28216|Betaproteobacteria	CO	oxidoreductase DsbE	dsbE	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
k59_1846088_1	768671.ThimaDRAFT_0933	6.09e-09	56.6	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,1WX3R@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
k59_1846088_2	1049564.TevJSym_bq00070	4.89e-12	69.7	COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1J4YP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB
k59_722933_2	644076.SCH4B_1494	3.98e-31	119.0	COG3239@1|root,COG3239@2|Bacteria,1MXA8@1224|Proteobacteria,2TUQG@28211|Alphaproteobacteria,4NBAI@97050|Ruegeria	28211|Alphaproteobacteria	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
k59_378476_2	1095767.CAHD01000025_gene1719	1.17e-45	150.0	COG4702@1|root,COG4702@2|Bacteria,2IFGG@201174|Actinobacteria,4F17G@85016|Cellulomonadaceae	201174|Actinobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
k59_316388_1	247490.KSU1_C0255	6.86e-54	193.0	COG3497@1|root,COG3497@2|Bacteria,2IXRX@203682|Planctomycetes	203682|Planctomycetes	S	Phage tail sheath C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_sheath_1,Phage_sheath_1C
k59_270225_1	228405.HNE_2398	1.48e-77	246.0	COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,2TSJR@28211|Alphaproteobacteria,43WHM@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
k59_972649_1	335543.Sfum_3450	3.07e-34	129.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,42N2B@68525|delta/epsilon subdivisions,2WJS9@28221|Deltaproteobacteria,2MQ4E@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Vacuole effluxer Atg22 like	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_972649_2	1121921.KB898707_gene892	1.96e-46	154.0	COG2983@1|root,COG2983@2|Bacteria,1RHMX@1224|Proteobacteria,1S5XU@1236|Gammaproteobacteria,2PNJJ@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	S	Putative zinc- or iron-chelating domain	ycgN	-	-	ko:K09160	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_1261784_1	1089546.AQUI01000002_gene4087	1.3e-16	75.9	COG3609@1|root,COG3609@2|Bacteria,2I6Q5@201174|Actinobacteria	201174|Actinobacteria	K	addiction module antidote protein, CC2985 family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1261784_2	1123024.AUII01000045_gene570	2.63e-46	150.0	COG2337@1|root,COG2337@2|Bacteria,2ISBP@201174|Actinobacteria	201174|Actinobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	mazF3	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006355,GO:0006401,GO:0006402,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0017148,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045927,GO:0045934,GO:0046483,GO:0046700,GO:0048518,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
k59_1548413_1	1123060.JONP01000021_gene3776	3.24e-21	94.0	COG0398@1|root,COG1502@1|root,COG0398@2|Bacteria,COG1502@2|Bacteria,1PHM2@1224|Proteobacteria,2VCFN@28211|Alphaproteobacteria,2JY3C@204441|Rhodospirillales	204441|Rhodospirillales	I	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_140468_1	1236541.BALL01000005_gene948	1.61e-44	161.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q9QR@267890|Shewanellaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1548417_1	998674.ATTE01000001_gene4206	1.61e-56	192.0	COG2143@1|root,COG2370@1|root,COG2143@2|Bacteria,COG2370@2|Bacteria,1QDKY@1224|Proteobacteria,1RZ7R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Thioredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
k59_782282_1	519989.ECTPHS_13420	3.32e-107	329.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1WW4U@135613|Chromatiales	135613|Chromatiales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_1197487_1	555779.Dthio_PD3802	1.28e-47	179.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_1198052_1	573065.Astex_0185	1.31e-19	85.9	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2TSJK@28211|Alphaproteobacteria,2KFRC@204458|Caulobacterales	204458|Caulobacterales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
k59_1198052_2	1187851.A33M_1338	6.83e-34	122.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,2UCJF@28211|Alphaproteobacteria,3FDDR@34008|Rhodovulum	28211|Alphaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
k59_1198052_3	663610.JQKO01000005_gene2424	5.47e-13	67.8	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria,3N9NH@45404|Beijerinckiaceae	28211|Alphaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_386377_1	1232437.KL662006_gene4434	3.3e-14	72.4	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MHWA@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k59_914712_1	1123229.AUBC01000003_gene2069	1.15e-118	357.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2TQMA@28211|Alphaproteobacteria,3JREF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome bd terminal oxidase subunit I	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_1607110_1	717785.HYPMC_2663	1.45e-85	271.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2TR9G@28211|Alphaproteobacteria,3N626@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1373044_1	28258.KP05_00980	5.87e-51	176.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,1RPE8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	COG2133 Glucose sorbosone dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
k59_1325936_1	909663.KI867150_gene1187	1.37e-47	167.0	COG3335@1|root,COG3335@2|Bacteria,1MW8A@1224|Proteobacteria,42RGI@68525|delta/epsilon subdivisions,2WNGP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_33
k59_1373046_1	1151119.KB895508_gene446	4.99e-25	98.6	COG0131@1|root,COG0131@2|Bacteria,2GKMD@201174|Actinobacteria,1W8FB@1268|Micrococcaceae	201174|Actinobacteria	E	imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15,4.2.1.19	ko:K01089,ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013,R03457	RC00017,RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
k59_1373046_2	1219585.HMPREF1631_00050	1.83e-11	67.4	2EDZV@1|root,337UP@2|Bacteria,2GV38@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1783427_1	391037.Sare_3193	2.19e-97	292.0	COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4DBTB@85008|Micromonosporales	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1854242_2	338963.Pcar_2988	8.19e-45	166.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42N78@68525|delta/epsilon subdivisions,2WM0M@28221|Deltaproteobacteria,43S51@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	mscS-2	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
k59_271003_1	446466.Cfla_2260	6.3e-148	430.0	COG3497@1|root,COG3497@2|Bacteria,2GMJA@201174|Actinobacteria	201174|Actinobacteria	S	tail sheath protein	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
k59_1262462_1	1205680.CAKO01000002_gene2921	3.47e-75	231.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,2JS04@204441|Rhodospirillales	204441|Rhodospirillales	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_727773_1	1121927.GOHSU_50_00130	1.61e-13	74.7	COG2114@1|root,COG2770@1|root,COG2114@2|Bacteria,COG2770@2|Bacteria,2GJRI@201174|Actinobacteria,4GAYH@85026|Gordoniaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
k59_271009_1	1458357.BG58_36465	5.82e-51	178.0	COG2985@1|root,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,2VKQA@28216|Betaproteobacteria,1K03M@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Aspartate alanine antiporter	aspT	-	-	-	-	-	-	-	-	-	-	-	Asp-Al_Ex,TrkA_C
k59_1017717_1	626887.J057_18540	5.78e-62	209.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,1RNQ2@1236|Gammaproteobacteria,4640F@72275|Alteromonadaceae	1236|Gammaproteobacteria	GM	nucleoside-diphosphate sugar epimerases	wbpM	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
k59_782825_1	1047013.AQSP01000142_gene184	6.65e-18	84.3	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1496952_1	2340.JV46_13030	1.05e-114	336.0	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,1S7ID@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_271015_1	697303.Thewi_0550	0.000145	48.1	COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,248Z4@186801|Clostridia,42EUQ@68295|Thermoanaerobacterales	186801|Clostridia	K	Response regulator receiver	yycF	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_199610_1	670307.HYPDE_41388	5.36e-57	192.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,2TSCV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Major facilitator superfamily	MA20_25070	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_492807_1	1713.JOFV01000002_gene502	2.8e-103	318.0	COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria,4F11S@85016|Cellulomonadaceae	201174|Actinobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_492807_2	1304865.JAGF01000001_gene2708	7.78e-38	127.0	COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria,4F1GW@85016|Cellulomonadaceae	201174|Actinobacteria	J	Binds the 23S rRNA	rpmE	GO:0008150,GO:0040007	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
k59_782826_1	1304865.JAGF01000001_gene2442	1.12e-99	301.0	COG3259@1|root,COG3259@2|Bacteria,2GQ33@201174|Actinobacteria	201174|Actinobacteria	C	PFAM Nickel-dependent hydrogenase, large subunit	hoxH	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
k59_782826_2	396588.Tgr7_1137	1.92e-06	50.1	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,1RW0G@1236|Gammaproteobacteria,1WYVW@135613|Chromatiales	135613|Chromatiales	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
k59_1373067_1	649638.Trad_2420	6.74e-65	214.0	COG0405@1|root,COG0405@2|Bacteria,1WI9V@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1136118_1	1190606.AJYG01000093_gene2033	8.82e-79	246.0	COG1179@1|root,COG1179@2|Bacteria,1MWXR@1224|Proteobacteria,1RMT3@1236|Gammaproteobacteria,1XSUQ@135623|Vibrionales	135623|Vibrionales	H	COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1	ygdL	-	-	ko:K22132	-	-	-	-	ko00000,ko03016	-	-	-	ThiF
k59_1433119_2	2340.JV46_13230	1.39e-92	289.0	COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,1S0TR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_1496961_1	768671.ThimaDRAFT_4530	7.81e-199	561.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,1TKAD@1236|Gammaproteobacteria,1X15X@135613|Chromatiales	135613|Chromatiales	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_93006_1	1448389.BAVQ01000022_gene1612	8.41e-21	87.8	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria	201174|Actinobacteria	K	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form	cobB	GO:0000726,GO:0003674,GO:0003824,GO:0003953,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006464,GO:0006471,GO:0006476,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016787,GO:0016798,GO:0016799,GO:0019213,GO:0019538,GO:0030312,GO:0033554,GO:0033558,GO:0034641,GO:0034979,GO:0035601,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070213,GO:0071214,GO:0071478,GO:0071479,GO:0071704,GO:0071944,GO:0090304,GO:0098732,GO:0104004,GO:0140096,GO:1901360,GO:1901564	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k59_93006_2	1078020.KEK_01735	8.08e-41	151.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,234YF@1762|Mycobacteriaceae	201174|Actinobacteria	C	aconitate hydratase	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_141064_1	1449976.KALB_8126	1.74e-103	311.0	COG3177@1|root,COG3177@2|Bacteria,2GN3K@201174|Actinobacteria,4E3SI@85010|Pseudonocardiales	201174|Actinobacteria	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N
k59_1326007_1	1120983.KB894571_gene2194	2.78e-68	214.0	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2TT1U@28211|Alphaproteobacteria,1JNUA@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
k59_973821_1	29581.BW37_04500	1.79e-09	66.2	28KUM@1|root,2ZABC@2|Bacteria,1R683@1224|Proteobacteria,2VPU1@28216|Betaproteobacteria,47661@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF2868)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2868,DUF3482
k59_93008_1	1172188.KB911827_gene4281	3.06e-162	476.0	28HJF@1|root,2Z7UK@2|Bacteria,2ICK7@201174|Actinobacteria,4FIJ9@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1262494_1	1403819.BATR01000168_gene5801	1.05e-59	202.0	COG0845@1|root,COG0845@2|Bacteria,46VEA@74201|Verrucomicrobia,2IUBR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_141070_1	765911.Thivi_4596	3.31e-48	162.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1WY2F@135613|Chromatiales	135613|Chromatiales	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_1667997_1	2340.JV46_21560	1.82e-42	149.0	COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,1RZQ2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	PFAM Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_973831_1	857087.Metme_0760	3.6e-126	372.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1XEFM@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_973831_2	469378.Ccur_07670	9.57e-06	50.4	COG1385@1|root,COG1385@2|Bacteria,2GTKX@201174|Actinobacteria,4CUQB@84998|Coriobacteriia	84998|Coriobacteriia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
k59_434031_1	472759.Nhal_0492	9e-31	117.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1WW8T@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
k59_434031_2	765912.Thimo_3108	2.25e-124	365.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1WWYB@135613|Chromatiales	135613|Chromatiales	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_610103_1	1121104.AQXH01000001_gene1385	2.56e-25	114.0	COG2091@1|root,COG2091@2|Bacteria,4NGXG@976|Bacteroidetes	976|Bacteroidetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_386510_1	765913.ThidrDRAFT_0665	7.61e-41	140.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria,1WWPE@135613|Chromatiales	135613|Chromatiales	G	HAD-superfamily hydrolase, subfamily IA, variant 3	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_1262510_2	768671.ThimaDRAFT_2363	1.28e-103	315.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1WXC2@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1607168_1	85643.Tmz1t_2214	2.19e-08	55.5	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,2VMD6@28216|Betaproteobacteria,2KVUZ@206389|Rhodocyclales	206389|Rhodocyclales	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
k59_1607168_2	1123279.ATUS01000001_gene989	6.51e-22	88.6	COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,1SD8H@1236|Gammaproteobacteria,1J6YW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0019954,GO:0022402,GO:0022414,GO:0030428,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044464,GO:0051301	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
k59_317040_1	640081.Dsui_1454	5.33e-41	150.0	COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,2VQGZ@28216|Betaproteobacteria,2KYI0@206389|Rhodocyclales	206389|Rhodocyclales	PT	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,cNMP_binding
k59_1198136_1	590998.Celf_0635	8.22e-45	161.0	COG3387@1|root,COG3387@2|Bacteria,2ICV9@201174|Actinobacteria,4F0TM@85016|Cellulomonadaceae	201174|Actinobacteria	G	PFAM glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_669330_1	1082931.KKY_2386	1.61e-89	281.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2TW3X@28211|Alphaproteobacteria,3N7JR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_8,PAS_9,Sigma54_activat
k59_386521_1	1000565.METUNv1_02171	3.05e-21	87.8	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2VQTQ@28216|Betaproteobacteria,2KW1F@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
k59_37688_1	1384056.N787_02780	6.05e-44	162.0	COG0591@1|root,COG0642@1|root,COG0745@1|root,COG0591@2|Bacteria,COG0745@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,1X43U@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
k59_914863_1	1131269.AQVV01000004_gene614	3.95e-13	70.9	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cohesin,DUF11,SLH
k59_1198147_1	370438.PTH_2122	1.04e-48	176.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,2602D@186807|Peptococcaceae	186801|Clostridia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1549069_1	631362.Thi970DRAFT_04180	6.25e-114	333.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,1WW0C@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_93103_1	1298863.AUEP01000012_gene3743	7.64e-41	146.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2GKAX@201174|Actinobacteria,4DNKD@85009|Propionibacteriales	201174|Actinobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016020,GO:0016070,GO:0034641,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_727846_1	1121943.KB899990_gene3681	3.56e-56	191.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1XHR4@135619|Oceanospirillales	135619|Oceanospirillales	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_1198161_1	1198232.CYCME_1354	1.8e-27	114.0	COG0803@1|root,COG0845@1|root,COG0803@2|Bacteria,COG0845@2|Bacteria,1MX8W@1224|Proteobacteria,1RPXR@1236|Gammaproteobacteria,4627X@72273|Thiotrichales	72273|Thiotrichales	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_1373137_2	1118054.CAGW01000032_gene683	5.37e-13	70.5	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli,26R6D@186822|Paenibacillaceae	91061|Bacilli	C	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively	yfmT	GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0018479,GO:0055114	1.2.1.3,1.2.1.67	ko:K00128,ko:K21802	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00627,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00627,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R05699,R06366,R08146	RC00047,RC00071,RC00075,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1783520_1	1095769.CAHF01000010_gene1341	1.22e-26	113.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VK3J@28216|Betaproteobacteria,473W1@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_46218_1	566466.NOR53_160	9.59e-72	232.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN5K@1236|Gammaproteobacteria,1J7JT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Outer membrane efflux protein	VPA1579	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1865551_1	765912.Thimo_2582	1.01e-90	285.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,1WWF4@135613|Chromatiales	135613|Chromatiales	S	ABC transporter	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_323448_2	1458427.BAWN01000032_gene1837	3.86e-57	191.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2VI0N@28216|Betaproteobacteria,4A9T8@80864|Comamonadaceae	28216|Betaproteobacteria	C	TIGRFAM methylmalonate-semialdehyde dehydrogenase	-	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1095236_1	1095767.CAHD01000175_gene2584	3.13e-71	228.0	COG0014@1|root,COG0014@2|Bacteria,2GISA@201174|Actinobacteria,4F0S7@85016|Cellulomonadaceae	201174|Actinobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2427c	Aldedh
k59_147614_1	102129.Lepto7375DRAFT_2011	7.98e-72	247.0	COG2909@1|root,COG2909@2|Bacteria,1G3UH@1117|Cyanobacteria,1HDU6@1150|Oscillatoriales	1117|Cyanobacteria	K	transcriptional regulator	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
k59_851603_2	1123065.ATWL01000001_gene136	2.33e-47	156.0	COG0784@1|root,COG0784@2|Bacteria,2II71@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_734539_1	765914.ThisiDRAFT_2218	7.52e-29	113.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1WWBG@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_1503947_1	1549858.MC45_17145	1.56e-44	156.0	COG4798@1|root,COG4798@2|Bacteria,1RHGZ@1224|Proteobacteria,2U7R8@28211|Alphaproteobacteria,2KDKG@204457|Sphingomonadales	204457|Sphingomonadales	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_734541_2	313589.JNB_05480	1.91e-26	105.0	2BGRN@1|root,32AQR@2|Bacteria,2IIE3@201174|Actinobacteria,4FF4I@85021|Intrasporangiaceae	201174|Actinobacteria	Q	2-nitropropane	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
k59_104034_1	1122604.JONR01000013_gene3213	7.75e-48	165.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,1RP7Q@1236|Gammaproteobacteria,1X337@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulator	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
k59_1865594_2	631362.Thi970DRAFT_01992	1.23e-30	118.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria,1WXHA@135613|Chromatiales	135613|Chromatiales	S	Peptidogalycan biosysnthesis/recognition	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
k59_851615_1	631362.Thi970DRAFT_03295	2e-92	283.0	COG2801@1|root,COG2801@2|Bacteria,1R6TH@1224|Proteobacteria,1RRWS@1236|Gammaproteobacteria,1X2I8@135613|Chromatiales	135613|Chromatiales	L	Mu transposase, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,Mu-transpos_C,rve
k59_1337323_1	335543.Sfum_2978	1.54e-30	112.0	2E47B@1|root,32Z37@2|Bacteria,1NC7T@1224|Proteobacteria,42VYF@68525|delta/epsilon subdivisions,2WRN2@28221|Deltaproteobacteria,2MSH3@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_926010_1	1043493.BBLU01000002_gene1594	2.28e-56	181.0	COG0321@1|root,COG0321@2|Bacteria,2GJIX@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_788175_1	1123368.AUIS01000019_gene1205	3.26e-162	463.0	COG3608@1|root,COG3608@2|Bacteria,1R784@1224|Proteobacteria,1RRY6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM Succinylglutamate desuccinylase Aspartoacylase	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
k59_788175_2	1430440.MGMSRv2_1155	4.36e-07	51.2	COG1819@1|root,COG1819@2|Bacteria,1MVJM@1224|Proteobacteria,2U8TE@28211|Alphaproteobacteria,2JSBP@204441|Rhodospirillales	204441|Rhodospirillales	CG	glycosyl	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_675936_1	1168034.FH5T_03280	3.5e-97	308.0	COG0457@1|root,COG0823@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	dppX	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
k59_1337331_1	469371.Tbis_3528	8.4e-63	204.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4DYQ8@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the aspartokinase family	ask	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
k59_1674509_1	631362.Thi970DRAFT_04866	1.39e-74	247.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1WXK8@135613|Chromatiales	135613|Chromatiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_397606_1	335543.Sfum_0752	3.48e-77	238.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,2MQFV@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	PFAM MotA TolQ ExbB proton channel	aglX	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
k59_1023064_1	1082931.KKY_2329	3.37e-121	369.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2TS8I@28211|Alphaproteobacteria,3N6HV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Nitrite reductase NAD(P)H , large subunit	nasD	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Rieske_2
k59_985152_1	28072.Nos7524_1286	9.18e-14	77.8	COG2931@1|root,COG3210@1|root,COG3291@1|root,COG3595@1|root,COG4070@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG3595@2|Bacteria,COG4070@2|Bacteria,1GHDQ@1117|Cyanobacteria,1HUA0@1161|Nostocales	1117|Cyanobacteria	Q	Domain of unknown function (DUF4114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114
k59_1439575_1	927704.SELR_08970	7.13e-55	184.0	COG1883@1|root,COG1883@2|Bacteria,1TPEP@1239|Firmicutes,4H275@909932|Negativicutes	909932|Negativicutes	C	sodium ion-translocating decarboxylase, beta subunit	gcdB	-	4.1.1.70	ko:K01615	ko00362,ko00650,ko01120,map00362,map00650,map01120	-	R03028	RC00832	ko00000,ko00001,ko01000,ko02000	3.B.1.1.3	-	-	OAD_beta
k59_985154_1	43989.cce_0186	5.61e-123	363.0	COG3930@1|root,COG3930@2|Bacteria,1G4P3@1117|Cyanobacteria,3KJJF@43988|Cyanothece	1117|Cyanobacteria	S	DUF1704	-	-	-	-	-	-	-	-	-	-	-	-	DUF1704
k59_1674517_1	1517416.IDAT_09080	1.35e-110	334.0	COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,1RNXP@1236|Gammaproteobacteria,2QF7V@267893|Idiomarinaceae	1236|Gammaproteobacteria	HJ	RimK-like ATPgrasp N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Dala_Dala_lig_C,RLAN,RimK
k59_1337359_1	1049564.TevJSym_an00030	4.48e-204	582.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1J7AF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	5'-nucleotidase, C-terminal domain	soxB	-	-	ko:K17224	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	5_nucleotid_C
k59_1337359_2	396588.Tgr7_2583	2.73e-26	102.0	COG1416@1|root,COG1416@2|Bacteria,1RBQX@1224|Proteobacteria,1S983@1236|Gammaproteobacteria,1X0YN@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_926063_1	246200.SPO0955	1.52e-91	287.0	COG1574@1|root,COG1574@2|Bacteria,1R53N@1224|Proteobacteria,2VF84@28211|Alphaproteobacteria,4NBCU@97050|Ruegeria	28211|Alphaproteobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_279286_1	999549.KI421513_gene2310	1.24e-13	77.8	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2V7K1@28211|Alphaproteobacteria,28205@191028|Leisingera	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_1095309_1	1026882.MAMP_00396	1.54e-60	194.0	COG4659@1|root,COG4659@2|Bacteria,1RDEP@1224|Proteobacteria,1RPAD@1236|Gammaproteobacteria,460RQ@72273|Thiotrichales	72273|Thiotrichales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
k59_440619_1	1121889.AUDM01000018_gene1227	4.42e-77	246.0	COG0366@1|root,COG0366@2|Bacteria,4NEVK@976|Bacteroidetes,1HYB7@117743|Flavobacteriia,2P04M@237|Flavobacterium	976|Bacteroidetes	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Alpha-amylase_C,Malt_amylase_C
k59_46312_1	880073.Calab_2472	1.75e-40	150.0	COG3225@1|root,COG3225@2|Bacteria,2NNVN@2323|unclassified Bacteria	2|Bacteria	N	ABC-type uncharacterized transport system	gldG	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC_transp_aux
k59_1439595_1	1386089.N865_12985	1.54e-36	139.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4FEI4@85021|Intrasporangiaceae	201174|Actinobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
k59_1337370_1	1384056.N787_06560	3.64e-33	125.0	COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,1RRQE@1236|Gammaproteobacteria,1X7AT@135614|Xanthomonadales	135614|Xanthomonadales	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh_C
k59_1337370_2	685035.ADAE01000002_gene2107	2.43e-22	89.0	COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,2UCR7@28211|Alphaproteobacteria,2K5MQ@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
k59_557861_1	331869.BAL199_15978	4.39e-130	383.0	COG3131@1|root,COG3131@2|Bacteria,1MUNX@1224|Proteobacteria,2TRU1@28211|Alphaproteobacteria,4BR6D@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)	mdoD	-	-	ko:K03670	-	-	-	-	ko00000	-	-	-	MdoG,TAT_signal
k59_926081_1	1293054.HSACCH_00944	1.9e-26	111.0	COG0475@1|root,COG0475@2|Bacteria,1TS32@1239|Firmicutes,247XW@186801|Clostridia,3WBF6@53433|Halanaerobiales	186801|Clostridia	P	PFAM sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_279307_1	1137799.GZ78_11680	7.89e-19	88.2	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,1S64Q@1236|Gammaproteobacteria,1XKS2@135619|Oceanospirillales	135619|Oceanospirillales	S	Competence protein	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
k59_1337391_1	446469.Sked_27430	4.48e-31	117.0	COG0667@1|root,COG0667@2|Bacteria,2GJ4R@201174|Actinobacteria	201174|Actinobacteria	C	aldo keto reductase	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
k59_1337391_2	1449355.JQNR01000005_gene4924	2.76e-62	200.0	COG1396@1|root,COG1396@2|Bacteria,2GJS3@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
k59_1731911_1	1121875.KB907546_gene2194	5.14e-22	97.4	COG3653@1|root,COG3653@2|Bacteria,4NHDD@976|Bacteroidetes,1I2RR@117743|Flavobacteriia	976|Bacteroidetes	Q	PFAM D-aminoacylase, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_852389_1	298655.KI912266_gene1774	4.95e-73	228.0	COG1079@1|root,COG1079@2|Bacteria,2GKMB@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_1096198_1	626887.J057_04961	2.1e-51	173.0	COG0596@1|root,COG0596@2|Bacteria,1R9X7@1224|Proteobacteria,1S2CW@1236|Gammaproteobacteria,466G8@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	ybfF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016788,GO:0016790,GO:0044424,GO:0044444,GO:0044464,GO:0052689	-	ko:K01175	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_788840_1	588932.JHOF01000018_gene1035	5.31e-70	238.0	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2TRU4@28211|Alphaproteobacteria,2KFCK@204458|Caulobacterales	204458|Caulobacterales	O	peptidase	-	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
k59_1338634_1	697282.Mettu_0273	0.000576	43.9	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,1RYPY@1236|Gammaproteobacteria,1XETG@135618|Methylococcales	1236|Gammaproteobacteria	S	PFAM Transposase, IS801 IS1294	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_47524_1	1049564.TevJSym_bc00380	2.67e-140	407.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1JBG6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cysteine-rich domain	dgcB	-	-	ko:K21834	-	-	-	-	ko00000	-	-	-	CCG,DUF3483,Fer4_8
k59_1338636_1	324602.Caur_0705	7.13e-121	382.0	COG0366@1|root,COG4733@1|root,COG0366@2|Bacteria,COG4733@2|Bacteria,2G7WY@200795|Chloroflexi,37544@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM_20,fn3
k59_398905_1	105559.Nwat_2091	9.49e-51	166.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria,1WY0M@135613|Chromatiales	135613|Chromatiales	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
k59_788845_1	551275.KB899544_gene886	2.64e-36	139.0	COG1231@1|root,COG1231@2|Bacteria,1MWPH@1224|Proteobacteria,2U05G@28211|Alphaproteobacteria,43YUX@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Flavin containing amine oxidoreductase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_1614392_1	1121934.AUDX01000024_gene1023	1.19e-64	221.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2GJU7@201174|Actinobacteria,4FKSY@85023|Microbacteriaceae	201174|Actinobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
k59_324277_1	713587.THITH_12040	2.79e-41	149.0	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,1RR1J@1236|Gammaproteobacteria,1WVZY@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,CbiA,GATase_3
k59_324277_2	765912.Thimo_0156	2.63e-41	138.0	COG0316@1|root,COG0316@2|Bacteria,1RKPC@1224|Proteobacteria,1SB76@1236|Gammaproteobacteria,1WYKT@135613|Chromatiales	135613|Chromatiales	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
k59_1789642_2	697282.Mettu_3826	3.5e-31	112.0	COG2827@1|root,COG2827@2|Bacteria,1N6PA@1224|Proteobacteria,1SCBH@1236|Gammaproteobacteria,1XFRS@135618|Methylococcales	135618|Methylococcales	L	GIY-YIG catalytic domain	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
k59_1789642_3	1415778.JQMM01000001_gene1035	1.35e-54	175.0	COG3091@1|root,COG3091@2|Bacteria,1N07A@1224|Proteobacteria,1S9E8@1236|Gammaproteobacteria,1J74J@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	SprT homologues.	sprT	-	-	ko:K02742	-	-	-	-	ko00000	-	-	-	SprT-like,Zn_ribbon_SprT
k59_1440390_1	590998.Celf_2620	3.11e-14	67.0	2EG89@1|root,33A03@2|Bacteria,2GX3U@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1732687_1	1120963.KB894500_gene100	1.31e-66	220.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	oligopeptide transporter	-	-	-	-	-	-	-	-	-	-	-	-	OPT
k59_207049_1	880073.Calab_1551	1.04e-100	310.0	COG1866@1|root,COG1866@2|Bacteria,2NQI3@2323|unclassified Bacteria	2|Bacteria	C	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3169	PEPCK_ATP
k59_735396_1	2340.JV46_12120	6.04e-117	349.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1J4E0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_1732688_1	323261.Noc_1374	9.24e-68	223.0	COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,1WXBQ@135613|Chromatiales	135613|Chromatiales	O	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_280472_1	1122134.KB893650_gene477	2.62e-52	186.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XI69@135619|Oceanospirillales	135619|Oceanospirillales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_207052_1	1121405.dsmv_3676	1.18e-64	206.0	COG1456@1|root,COG1456@2|Bacteria,1R9BV@1224|Proteobacteria,42P65@68525|delta/epsilon subdivisions,2WMGX@28221|Deltaproteobacteria,2MHNZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF3786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786,FeS
k59_1504981_1	1123401.JHYQ01000005_gene263	6.59e-107	317.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,1SQ2U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Thiosulfate-oxidizing multienzyme system protein SoxA	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1504981_2	1123401.JHYQ01000005_gene262	3.54e-45	149.0	COG2010@1|root,COG2010@2|Bacteria,1RIV2@1224|Proteobacteria,1SV6K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_788865_1	396588.Tgr7_1915	2.49e-85	265.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,1WVX4@135613|Chromatiales	135613|Chromatiales	I	TIGRFAM acetyl-CoA carboxylase, biotin carboxylase	-	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_788865_2	1249627.D779_1541	5.34e-253	708.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1WW0Z@135613|Chromatiales	135613|Chromatiales	CI	TIGRFAM Oxaloacetate decarboxylase, alpha subunit	-	-	6.4.1.1	ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_927370_1	1219080.VEZ01S_37_01400	6.7e-12	66.6	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1XT2B@135623|Vibrionales	135623|Vibrionales	M	COG5009 Membrane carboxypeptidase penicillin-binding protein	mrcA	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_207055_1	1144275.COCOR_07526	3.84e-58	200.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WKYA@28221|Deltaproteobacteria,2YU1C@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefB	-	-	ko:K03455,ko:K11745,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.1,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
k59_1023784_1	446469.Sked_08990	9.3e-19	84.3	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	wbbL_1	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
k59_1023784_2	446466.Cfla_2353	1.47e-20	93.6	COG2244@1|root,COG2244@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0008150,GO:0009987,GO:0044764,GO:0046812,GO:0051704	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	Polysacc_synt,Polysacc_synt_3
k59_676797_1	1121405.dsmv_2749	5.86e-26	107.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,2MIPG@213118|Desulfobacterales	28221|Deltaproteobacteria	G	phosphorylase	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_676797_2	1121405.dsmv_2750	7.79e-31	120.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2MIZ1@213118|Desulfobacterales	28221|Deltaproteobacteria	G	PFAM Starch synthase catalytic	-	-	2.4.1.21,3.2.1.1	ko:K00703,ko:K01176	ko00500,ko01100,ko01110,ko02026,ko04973,map00500,map01100,map01110,map02026,map04973	M00565	R02108,R02112,R02421,R11262	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GH13,GT5	-	Glyco_trans_1_4,Glyco_transf_5,Glycos_transf_1
k59_1205278_1	670307.HYPDE_36103	6.13e-16	78.2	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TQRE@28211|Alphaproteobacteria,3N804@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Signal transduction histidine kinase	envZ	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_47595_1	697282.Mettu_2060	4.16e-69	236.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,1XEJM@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0753 family	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k59_1142341_2	631362.Thi970DRAFT_00760	2.96e-52	178.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,1RM9Z@1236|Gammaproteobacteria,1WX87@135613|Chromatiales	135613|Chromatiales	S	PFAM Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_676798_1	1198232.CYCME_1355	2.05e-33	129.0	COG1538@1|root,COG1538@2|Bacteria,1MVT8@1224|Proteobacteria,1RQ88@1236|Gammaproteobacteria,462YB@72273|Thiotrichales	72273|Thiotrichales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_324304_1	582899.Hden_0978	2.91e-61	195.0	COG1309@1|root,COG1309@2|Bacteria,1RFXC@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
k59_148504_1	1123371.ATXH01000005_gene2088	2.84e-11	62.0	2DSVZ@1|root,33HMA@2|Bacteria,2GH7Y@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_852440_1	713586.KB900536_gene3046	2.01e-213	595.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_291517_1	1249627.D779_3018	5.5e-06	48.1	COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,1S3XB@1236|Gammaproteobacteria,1WYGA@135613|Chromatiales	135613|Chromatiales	F	Nudix N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N_2
k59_332590_1	640081.Dsui_2110	3.17e-90	279.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2VP05@28216|Betaproteobacteria	28216|Betaproteobacteria	L	transposase IS116 IS110 IS902 family protein	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_291526_1	1469613.JT55_05385	1.22e-86	257.0	COG3791@1|root,COG3791@2|Bacteria,1RD31@1224|Proteobacteria,2U7QB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating, GFA	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_1388365_1	1158338.JNLJ01000005_gene1735	4.17e-06	47.4	COG0060@1|root,COG0060@2|Bacteria,2G3PN@200783|Aquificae	200783|Aquificae	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_1388365_2	713586.KB900536_gene1907	5.77e-63	203.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1WWQ1@135613|Chromatiales	135613|Chromatiales	H	Belongs to the ribF family	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
k59_685000_1	1123065.ATWL01000002_gene1712	1.2e-49	179.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria	201174|Actinobacteria	L	dead DEAH box helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
k59_1513733_1	886293.Sinac_2219	5.95e-23	93.2	COG0824@1|root,COG0824@2|Bacteria,2J0QJ@203682|Planctomycetes	203682|Planctomycetes	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT_2
k59_1513733_2	207954.MED92_15293	1.63e-23	90.9	295Q8@1|root,2ZT1K@2|Bacteria,1P6YB@1224|Proteobacteria,1SVYT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1513733_3	1255043.TVNIR_0368	4.63e-07	48.9	2EFZ6@1|root,339RC@2|Bacteria,1P76P@1224|Proteobacteria,1SIDJ@1236|Gammaproteobacteria,1X1PM@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1683153_1	398578.Daci_3661	3.82e-88	270.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,2VHVD@28216|Betaproteobacteria,4ABW5@80864|Comamonadaceae	28216|Betaproteobacteria	C	TIGRFAM isocitrate dehydrogenase, NADP-dependent	icd	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_566742_1	998674.ATTE01000001_gene2676	1.31e-161	476.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,4601N@72273|Thiotrichales	72273|Thiotrichales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_860117_2	78398.KS43_15495	1.15e-72	227.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,1RMGB@1236|Gammaproteobacteria,1MQR3@122277|Pectobacterium	1236|Gammaproteobacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008955,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
k59_1032177_2	1249627.D779_1894	1.52e-66	205.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,1WWV2@135613|Chromatiales	135613|Chromatiales	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
k59_508192_1	221288.JH992901_gene2581	2.13e-94	289.0	COG3146@1|root,COG3146@2|Bacteria,1G0U8@1117|Cyanobacteria,1JI10@1189|Stigonemataceae	1117|Cyanobacteria	S	Peptidogalycan biosysnthesis/recognition	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
k59_1212938_1	1894.JOER01000088_gene3401	6.06e-209	596.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1448161_1	1123258.AQXZ01000016_gene2353	6.29e-76	239.0	COG0208@1|root,COG0208@2|Bacteria,2GJKZ@201174|Actinobacteria,4G72S@85025|Nocardiaceae	201174|Actinobacteria	F	P-aminobenzoate N-oxygenase AurF	-	-	-	-	-	-	-	-	-	-	-	-	AurF
k59_1513752_1	765910.MARPU_11570	3.76e-132	382.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1WWPK@135613|Chromatiales	135613|Chromatiales	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_743701_1	1121124.JNIX01000003_gene1118	3.67e-05	48.1	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TS4W@28211|Alphaproteobacteria,2KFBD@204458|Caulobacterales	204458|Caulobacterales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_685028_1	765912.Thimo_1916	2.81e-18	85.1	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WWIV@135613|Chromatiales	135613|Chromatiales	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_566759_2	1120977.JHUX01000003_gene1696	8.61e-24	100.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,3NJ8A@468|Moraxellaceae	1236|Gammaproteobacteria	E	B12 binding domain	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_215062_1	391595.RLO149_p630440	1.94e-81	251.0	COG1216@1|root,COG1216@2|Bacteria,1NM61@1224|Proteobacteria,2TRZB@28211|Alphaproteobacteria,2P3NR@2433|Roseobacter	28211|Alphaproteobacteria	S	Glycosyltransferase like family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glyco_transf_7C,Glycos_transf_2
k59_449506_1	90813.JQMT01000001_gene309	6.48e-40	143.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,461KC@72273|Thiotrichales	72273|Thiotrichales	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
k59_449506_2	411902.CLOBOL_00583	6.55e-07	52.4	COG1396@1|root,COG1396@2|Bacteria,1VI1G@1239|Firmicutes,24SDQ@186801|Clostridia,2217P@1506553|Lachnoclostridium	186801|Clostridia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19
k59_625407_1	631454.N177_3290	4.18e-85	258.0	COG3485@1|root,COG3485@2|Bacteria,1MUYX@1224|Proteobacteria,2TU2C@28211|Alphaproteobacteria,1JNUR@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Protocatechuate 3,4-dioxygenase beta subunit N terminal	pcaH	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C,PCDO_beta_N
k59_215066_1	1713.JOFV01000008_gene3213	9.21e-75	243.0	COG0433@1|root,COG0433@2|Bacteria,2GM12@201174|Actinobacteria,4F1SD@85016|Cellulomonadaceae	201174|Actinobacteria	S	Domain of unknown function DUF87	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
k59_625409_1	1463895.JODA01000013_gene36	1.04e-15	82.8	COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria	201174|Actinobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_939211_1	765910.MARPU_02035	4.06e-174	508.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria,1WXUR@135613|Chromatiales	135613|Chromatiales	P	PFAM Na Picotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
k59_1740961_1	1122194.AUHU01000011_gene1676	0.000343	43.5	COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,1S8UU@1236|Gammaproteobacteria,4677J@72275|Alteromonadaceae	1236|Gammaproteobacteria	CO	Thioredoxin-like	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
k59_156823_2	1304275.C41B8_07417	4.5e-07	52.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Type II secretory pathway component ExeA	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
k59_685043_1	768671.ThimaDRAFT_0808	5.13e-12	65.5	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,1WXN7@135613|Chromatiales	135613|Chromatiales	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_1513782_1	1198232.CYCME_0645	1.95e-82	251.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,4604Q@72273|Thiotrichales	72273|Thiotrichales	D	TIGRFAM Cell division ATP-binding protein FtsE	-	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_1513782_2	1304275.C41B8_00600	4.37e-09	59.7	COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0009274,GO:0009276,GO:0009987,GO:0016020,GO:0016021,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032153,GO:0044425,GO:0044464,GO:0051301,GO:0071944	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
k59_795308_1	1120941.AUBL01000003_gene1863	4.3e-114	353.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,2GK2D@201174|Actinobacteria,4D3V4@85005|Actinomycetales	201174|Actinobacteria	M	Glycosyltransferase, group 2 family protein	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glyco_trans_1_4,Glycos_transf_1,Glycos_transf_2
k59_508221_1	1121405.dsmv_1025	8.49e-11	64.7	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2MHTH@213118|Desulfobacterales	28221|Deltaproteobacteria	KLT	PFAM Protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_508221_2	264732.Moth_0909	1.67e-21	94.4	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,42EM8@68295|Thermoanaerobacterales	186801|Clostridia	T	protein phosphatase 2C domain protein	prpC	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2,SpoIIE
k59_291618_1	215803.DB30_1496	3.88e-05	52.0	COG1672@1|root,COG2319@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,1NIID@1224|Proteobacteria,42YIQ@68525|delta/epsilon subdivisions,2WUCK@28221|Deltaproteobacteria,2YTXX@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_566784_1	1121405.dsmv_0905	9.95e-110	328.0	COG0064@1|root,COG0064@2|Bacteria,1R4CK@1224|Proteobacteria,42MIU@68525|delta/epsilon subdivisions,2WKCI@28221|Deltaproteobacteria,2MPSS@213118|Desulfobacterales	28221|Deltaproteobacteria	J	GatB domain	-	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_1032227_1	324925.Ppha_1640	1.21e-39	150.0	COG3387@1|root,COG3387@2|Bacteria,1FE8X@1090|Chlorobi	1090|Chlorobi	G	Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	DUF547,Glyco_hydro_15
k59_1149612_2	566466.NOR53_10	1.24e-31	114.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1S01K@1236|Gammaproteobacteria,1J7W3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	L COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1622382_1	648757.Rvan_0219	3.91e-55	200.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,3N6E3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the helicase family. UvrD subfamily	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_939248_1	1003195.SCAT_0380	9.75e-28	114.0	COG4076@1|root,COG4076@2|Bacteria,2IA0E@201174|Actinobacteria	201174|Actinobacteria	S	Ribosomal protein L11 methyltransferase (PrmA)	-	-	2.1.1.319,2.1.1.320	ko:K11434,ko:K19737,ko:K21170	ko01059,ko01130,ko04068,ko04922,map01059,map01130,map04068,map04922	M00825	R11216,R11217,R11218,R11219,R11220	RC00003,RC02120,RC03388,RC03389,RC03390,RC03391	ko00000,ko00001,ko00002,ko01000,ko03036	-	-	-	Methyltransf_25,PRMT5_C,PrmA
k59_795324_1	935840.JAEQ01000028_gene1054	8.63e-106	331.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,43HTR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1149617_1	1451261.AS96_02280	1.14e-19	90.9	COG0671@1|root,COG1597@1|root,COG0671@2|Bacteria,COG1597@2|Bacteria,2GM2U@201174|Actinobacteria	201174|Actinobacteria	I	Diacylglycerol kinase	bmrU	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	DAGK_cat,PAP2
k59_1513812_1	1049564.TevJSym_at00270	9.21e-48	164.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1J4S5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	COG4942 Membrane-bound metallopeptidase	envC	GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1513812_2	857087.Metme_0275	8.86e-08	54.3	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1XEI9@135618|Methylococcales	135618|Methylococcales	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_332681_1	1033802.SSPSH_003347	5.13e-55	185.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_332681_2	1121013.P873_11365	1.75e-07	48.9	COG0254@1|root,COG0254@2|Bacteria,1MZ4D@1224|Proteobacteria,1S8V5@1236|Gammaproteobacteria,1X7FM@135614|Xanthomonadales	135614|Xanthomonadales	J	Ribosomal protein L31	rpmE2	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
k59_332683_1	754476.Q7A_2355	3.18e-43	158.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,45ZN8@72273|Thiotrichales	72273|Thiotrichales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_1513816_1	596151.DesfrDRAFT_3140	4.15e-31	130.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,42PT5@68525|delta/epsilon subdivisions,2WIPN@28221|Deltaproteobacteria,2M94M@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	NADH-quinone oxidoreductase, chain G	nuoG-2	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_939272_1	28229.ND2E_3821	1.87e-70	231.0	COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria,1S06C@1236|Gammaproteobacteria,2Q7GQ@267889|Colwelliaceae	1236|Gammaproteobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	pafA	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
k59_860191_1	391589.RGAI101_26	3.36e-10	72.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,Big_5,Cadherin,DUF4347,HemolysinCabind,Hint_2
k59_1683240_1	1385935.N836_20045	2.54e-73	245.0	COG0474@1|root,COG0474@2|Bacteria,1G0JX@1117|Cyanobacteria,1H7PF@1150|Oscillatoriales	1117|Cyanobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_566815_1	114615.BRADO0716	8.25e-17	80.1	COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,2TU80@28211|Alphaproteobacteria,3JQR6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	methyltransferase activity	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU,PEMT
k59_566815_2	1123508.JH636442_gene4266	4.04e-17	77.8	COG2128@1|root,COG2128@2|Bacteria,2IZDY@203682|Planctomycetes	203682|Planctomycetes	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_215127_1	1255043.TVNIR_2618	5.05e-72	231.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WXBN@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD linked oxidase domain protein	-	-	1.1.5.12	ko:K03777	ko00620,ko01120,map00620,map01120	-	R00704,R11591	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1388460_1	631362.Thi970DRAFT_04969	1.22e-67	216.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1WW9F@135613|Chromatiales	135613|Chromatiales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1388460_2	1049564.TevJSym_ar00100	5.54e-13	66.6	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,1S41P@1236|Gammaproteobacteria,1J637@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
k59_1622413_1	713586.KB900536_gene2586	9.06e-146	449.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales	135613|Chromatiales	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_215137_1	95619.PM1_0227105	1.85e-74	241.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	FP	Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the stringent response , an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities	gppA	GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006082,GO:0006139,GO:0006725,GO:0006793,GO:0006797,GO:0006798,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008894,GO:0009056,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034641,GO:0042594,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:1901360,GO:1901575	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c42590,iECED1_1282.ECED1_4463,iECIAI39_1322.ECIAI39_2643	HD,Ppx-GppA
k59_1741032_1	864051.BurJ1DRAFT_3952	5.88e-101	312.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,1KJ3N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Biotin carboxylase C-terminal domain	pccA	-	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_1105255_1	504472.Slin_1864	3.28e-25	111.0	COG1262@1|root,COG4409@1|root,COG1262@2|Bacteria,COG4409@2|Bacteria,4NJC9@976|Bacteroidetes,47XAC@768503|Cytophagia	976|Bacteroidetes	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2,FGE-sulfatase
k59_156895_1	743718.Isova_0379	3.4e-98	308.0	COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria,4F38P@85017|Promicromonosporaceae	201174|Actinobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_215143_1	762376.AXYL_01557	1.4e-41	145.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2VI4M@28216|Betaproteobacteria,3T2V1@506|Alcaligenaceae	28216|Betaproteobacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
k59_1032291_1	1504319.GM45_1765	5.64e-17	78.6	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF3566
k59_1032291_2	1394178.AWOO02000011_gene3865	0.000223	43.9	COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,4EFY8@85012|Streptosporangiales	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV,Intein_splicing,LAGLIDADG_3
k59_1741041_1	1124780.ANNU01000029_gene940	5.06e-18	85.1	COG4974@1|root,COG4974@2|Bacteria,4NIRH@976|Bacteroidetes,47M75@768503|Cytophagia	976|Bacteroidetes	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_743798_2	519989.ECTPHS_10936	2.62e-116	337.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,1WW24@135613|Chromatiales	135613|Chromatiales	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
k59_158055_1	713586.KB900536_gene245	2.3e-117	339.0	COG0599@1|root,COG2146@1|root,COG0599@2|Bacteria,COG2146@2|Bacteria,1RCCG@1224|Proteobacteria	1224|Proteobacteria	P	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD,Rieske
k59_1214376_2	562973.HMPREF0059_00449	5.68e-52	165.0	2CC1Y@1|root,32RUK@2|Bacteria,2IQ4Q@201174|Actinobacteria,4D6CU@85005|Actinomycetales	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB2	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
k59_509610_1	998674.ATTE01000001_gene3819	5.12e-81	249.0	COG2159@1|root,COG2159@2|Bacteria,1R44U@1224|Proteobacteria,1S88Y@1236|Gammaproteobacteria,462IW@72273|Thiotrichales	72273|Thiotrichales	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1742478_1	1121405.dsmv_1440	4.35e-67	225.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NHP@68525|delta/epsilon subdivisions,2X6U1@28221|Deltaproteobacteria,2MHMI@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM ribonuclease II	-	-	3.1.13.1	ko:K01147,ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_1033724_1	1316936.K678_02543	8.23e-06	53.1	COG3025@1|root,COG5607@1|root,COG3025@2|Bacteria,COG5607@2|Bacteria,1MY43@1224|Proteobacteria,2TQRV@28211|Alphaproteobacteria,2JQ4S@204441|Rhodospirillales	204441|Rhodospirillales	S	CYTH	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
k59_1389662_2	994573.T472_0219595	1.5e-27	110.0	COG1148@1|root,COG1148@2|Bacteria,1UN0D@1239|Firmicutes,25GTW@186801|Clostridia	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
k59_1797938_2	948106.AWZT01000021_gene2968	1.53e-142	412.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2VH3Z@28216|Betaproteobacteria,1K0ZE@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_573570_1	472759.Nhal_3098	1.86e-09	58.2	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RMKV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Amino Acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_573570_2	472759.Nhal_3602	1.05e-207	581.0	COG1180@1|root,COG1180@2|Bacteria,1R8XY@1224|Proteobacteria,1T0C7@1236|Gammaproteobacteria,1X2MB@135613|Chromatiales	135613|Chromatiales	O	Radical SAM superfamily	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_1156039_1	1121405.dsmv_3568	3.89e-06	44.3	COG0257@1|root,COG0257@2|Bacteria,1NGEI@1224|Proteobacteria,42WXD@68525|delta/epsilon subdivisions,2WSYK@28221|Deltaproteobacteria,2MM7P@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
k59_1156039_2	96561.Dole_0729	2.34e-41	136.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,42TRU@68525|delta/epsilon subdivisions,2WPZK@28221|Deltaproteobacteria,2MKKE@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
k59_1803014_1	1282876.BAOK01000002_gene390	2e-71	240.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,4BPGQ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_164179_1	257313.BP0074	4.39e-98	303.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2VHHJ@28216|Betaproteobacteria,3T2E8@506|Alcaligenaceae	28216|Betaproteobacteria	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
k59_164179_2	1156919.QWC_12036	7.91e-43	149.0	COG0697@1|root,COG0697@2|Bacteria,1MW7P@1224|Proteobacteria,2VHDI@28216|Betaproteobacteria,3T6XY@506|Alcaligenaceae	28216|Betaproteobacteria	EG	Permeases of the drug metabolite transporter (DMT) superfamily	ytfF	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1288982_2	933262.AXAM01000039_gene1171	4.4e-71	232.0	COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1MVD5@1224|Proteobacteria,42NQY@68525|delta/epsilon subdivisions,2WISG@28221|Deltaproteobacteria,2MIXC@213118|Desulfobacterales	28221|Deltaproteobacteria	HP	MoeA domain protein domain I and II	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
k59_1040672_1	990285.RGCCGE502_04655	8.58e-32	120.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2TRK6@28211|Alphaproteobacteria,4B74A@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
k59_1040672_2	466038.KI421440_gene116	1.67e-17	81.6	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,4BP7R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_1523043_1	1049564.TevJSym_aw00020	2.51e-57	200.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMA7@1236|Gammaproteobacteria,1J4SD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	COG0308 Aminopeptidase N	pepN	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	iECIAI1_1343.ECIAI1_0973,iECO103_1326.ECO103_0977,iECP_1309.ECP_0944,iECSE_1348.ECSE_0993,iECW_1372.ECW_m1042,iEKO11_1354.EKO11_2898,iWFL_1372.ECW_m1042	DUF3458,DUF3458_C,Peptidase_M1
k59_692046_1	331869.BAL199_22102	6.02e-07	50.8	COG1173@1|root,COG1173@2|Bacteria,1MU7Z@1224|Proteobacteria,2TTM9@28211|Alphaproteobacteria,4BT9X@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_692046_2	1123399.AQVE01000013_gene242	1.95e-98	307.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,45ZN9@72273|Thiotrichales	1236|Gammaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032,ko:K13896	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	ABC_tran,oligo_HPY
k59_1571903_1	1049564.TevJSym_ap00490	4.25e-78	248.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1J5NF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1523049_1	765913.ThidrDRAFT_3536	1.27e-72	225.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,1WX0N@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_1395770_1	323261.Noc_0358	6.88e-80	257.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1WW2F@135613|Chromatiales	135613|Chromatiales	P	Chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
k59_456297_1	1249627.D779_1614	1.12e-108	322.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,1WWXZ@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
k59_1803039_2	1215092.PA6_082_00040	1.15e-06	51.6	COG2963@1|root,COG2963@2|Bacteria,1PKKE@1224|Proteobacteria,1TC41@1236|Gammaproteobacteria,1YK7A@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1395792_1	472759.Nhal_0581	7.95e-83	256.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,1RM84@1236|Gammaproteobacteria,1WWYX@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM lysine 2,3-aminomutase YodO family protein	-	-	5.4.3.2	ko:K01843,ko:K19810	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000,ko03012	-	-	-	Fer4_12,Fer4_14,Radical_SAM
k59_1523088_1	504472.Slin_2662	5.8e-84	258.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,4NJ32@976|Bacteroidetes,47TE9@768503|Cytophagia	976|Bacteroidetes	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
k59_456308_2	595460.RRSWK_03283	4.5e-33	128.0	COG0531@1|root,COG0589@1|root,COG0531@2|Bacteria,COG0589@2|Bacteria,2J0UK@203682|Planctomycetes	203682|Planctomycetes	E	Amino acid permease	-	-	-	ko:K16238	-	-	-	-	ko00000,ko02000	2.A.3.5	-	-	AA_permease_2
k59_692073_1	1151122.AQYD01000007_gene665	1.56e-125	410.0	COG2911@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG4625@1|root,COG4932@1|root,COG5373@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,COG4625@2|Bacteria,COG4932@2|Bacteria,COG5373@2|Bacteria	2|Bacteria	KLT	membrane	-	-	-	ko:K02451,ko:K03832,ko:K13735,ko:K20276,ko:K21449	ko02024,ko05100,map02024,map05100	M00331	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	1.B.40.2,2.C.1.1,9.B.42	-	-	PATR,T2SSB
k59_632704_1	1116472.MGMO_84c00070	1.06e-69	220.0	COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria,1S58J@1236|Gammaproteobacteria,1XG72@135618|Methylococcales	135618|Methylococcales	D	Cellulose biosynthesis protein BcsQ	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
k59_1289048_2	187272.Mlg_1946	1.57e-136	395.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1WVXW@135613|Chromatiales	135613|Chromatiales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
k59_1114294_1	335283.Neut_2336	2.75e-81	253.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2VJRR@28216|Betaproteobacteria,371SF@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_1040750_1	1267005.KB911263_gene1340	5.48e-49	177.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,2TTGI@28211|Alphaproteobacteria,3N9E8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Phosphate acyltransferases	aas	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase,MFS_1
k59_1571961_1	1121405.dsmv_3691	1.92e-09	57.8	COG3547@1|root,COG3547@2|Bacteria,1NP2U@1224|Proteobacteria,43A5Q@68525|delta/epsilon subdivisions,2X2AM@28221|Deltaproteobacteria,2MPDW@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1748364_1	595460.RRSWK_02095	9.88e-82	259.0	COG4146@1|root,COG4146@2|Bacteria,2J29I@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_1630128_1	96561.Dole_0848	3.67e-22	95.5	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2MIZ1@213118|Desulfobacterales	28221|Deltaproteobacteria	G	PFAM Starch synthase catalytic	-	-	2.4.1.21,3.2.1.1	ko:K00703,ko:K01176	ko00500,ko01100,ko01110,ko02026,ko04973,map00500,map01100,map01110,map02026,map04973	M00565	R02108,R02112,R02421,R11262	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GH13,GT5	-	Glyco_trans_1_4,Glyco_transf_5,Glycos_transf_1
k59_1630128_2	96561.Dole_1327	1.81e-24	95.9	2AHR5@1|root,3183F@2|Bacteria,1Q8IK@1224|Proteobacteria,437FS@68525|delta/epsilon subdivisions,2X2NC@28221|Deltaproteobacteria,2MP9A@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1395820_1	1121937.AUHJ01000050_gene1244	1.35e-171	488.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria,464M3@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1803074_1	330084.JNYZ01000007_gene8826	2.34e-11	67.8	COG1309@1|root,COG1309@2|Bacteria,2GNHX@201174|Actinobacteria,4E47Z@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_573633_1	56780.SYN_01757	2.35e-17	85.9	COG4966@1|root,COG4966@2|Bacteria,1Q8WE@1224|Proteobacteria,439J3@68525|delta/epsilon subdivisions,2X4VK@28221|Deltaproteobacteria,2MSHQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
k59_1571973_1	998674.ATTE01000001_gene510	2.56e-38	136.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria,46075@72273|Thiotrichales	72273|Thiotrichales	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
k59_1571973_2	1499686.BN1079_03088	1.3e-56	182.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,1S60E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
k59_1571973_3	765914.ThisiDRAFT_2578	2.29e-18	83.6	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1WXI8@135613|Chromatiales	135613|Chromatiales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_870858_2	748280.NH8B_1923	2.3e-26	106.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2VH6I@28216|Betaproteobacteria,2KQMW@206351|Neisseriales	206351|Neisseriales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	comL	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
k59_342256_1	457570.Nther_0643	1.5e-44	164.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_458064_1	1035308.AQYY01000001_gene2842	9.33e-84	250.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl,zinc_ribbon_2
k59_1750182_1	216142.LT40_00670	2.2e-37	139.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_1043472_1	1157632.AQWQ01000005_gene921	1.96e-33	129.0	COG1960@1|root,COG1960@2|Bacteria,2GMKM@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
k59_1693282_1	1190606.AJYG01000197_gene4260	6.41e-58	198.0	COG2873@1|root,COG2873@2|Bacteria,1R3QG@1224|Proteobacteria,1RNSA@1236|Gammaproteobacteria,1XUQ3@135623|Vibrionales	135623|Vibrionales	E	Cys Met metabolism pyridoxal-phosphate-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Cys_Met_Meta_PP
k59_1397970_1	754477.Q7C_1325	2.55e-69	234.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,45ZQ4@72273|Thiotrichales	72273|Thiotrichales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_166536_1	742767.HMPREF9456_01921	3.79e-59	192.0	COG1023@1|root,COG1023@2|Bacteria,4PM5B@976|Bacteroidetes,2G10Y@200643|Bacteroidia,2327N@171551|Porphyromonadaceae	976|Bacteroidetes	G	6-phosphogluconate dehydrogenase, C-terminal domain	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
k59_753523_1	999141.GME_18108	6.55e-15	72.8	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,1SD9K@1236|Gammaproteobacteria,1XM56@135619|Oceanospirillales	135619|Oceanospirillales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	-	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_753523_2	1123514.KB905899_gene1969	9.07e-19	79.7	COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,1SCC7@1236|Gammaproteobacteria,461D2@72273|Thiotrichales	72273|Thiotrichales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_802505_1	1380354.JIAN01000005_gene2436	6.22e-65	210.0	COG0706@1|root,COG0706@2|Bacteria,2GJBU@201174|Actinobacteria,4F12K@85016|Cellulomonadaceae	201174|Actinobacteria	U	PFAM 60 kDa inner membrane insertion protein	yidC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
k59_516327_1	876044.IMCC3088_635	9.11e-105	313.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1MWNX@1224|Proteobacteria,1RQHG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,LZ_Tnp_IS481,rve
k59_870890_2	756499.Desde_2028	1.3e-13	67.0	COG2512@1|root,COG2512@2|Bacteria,1V848@1239|Firmicutes,24MDR@186801|Clostridia,262BA@186807|Peptococcaceae	186801|Clostridia	S	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1043507_1	1121405.dsmv_0958	4.82e-105	319.0	COG1061@1|root,COG1061@2|Bacteria,1QWMJ@1224|Proteobacteria,42NXF@68525|delta/epsilon subdivisions,2WJWA@28221|Deltaproteobacteria,2MHPY@213118|Desulfobacterales	28221|Deltaproteobacteria	L	type III restriction protein res subunit	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,ResIII
k59_166555_1	1255043.TVNIR_0224	2.97e-94	285.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,1RMAX@1236|Gammaproteobacteria,1WX8X@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
k59_634491_1	1123228.AUIH01000014_gene280	7.53e-117	339.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,1XI2U@135619|Oceanospirillales	135619|Oceanospirillales	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_634491_2	233412.HD_0738	9.48e-09	55.8	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1RMIZ@1236|Gammaproteobacteria,1Y7GC@135625|Pasteurellales	135625|Pasteurellales	K	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	crp	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	Crp,cNMP_binding
k59_1632572_1	765912.Thimo_1415	2.03e-24	102.0	COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,1RPY4@1236|Gammaproteobacteria,1WWHS@135613|Chromatiales	135613|Chromatiales	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
k59_1632572_2	1379270.AUXF01000001_gene2659	1.68e-12	69.3	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
k59_694173_1	471853.Bcav_1263	2.51e-147	429.0	COG0128@1|root,COG0128@2|Bacteria,2GJKX@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_458104_1	1040982.AXAL01000006_gene297	4.11e-33	135.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43JWG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16,TPR_2,TPR_8
k59_1693347_1	1168034.FH5T_20550	8.6e-117	347.0	COG2223@1|root,COG2223@2|Bacteria,4NHX9@976|Bacteroidetes,2FZ04@200643|Bacteroidia	976|Bacteroidetes	P	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
k59_802547_1	575593.HMPREF0491_02178	2.52e-72	233.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,27J2B@186928|unclassified Lachnospiraceae	186801|Clostridia	I	Thiolase, C-terminal domain	thlA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1632599_1	367299.JOEE01000007_gene70	1.64e-125	380.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,4FFG4@85021|Intrasporangiaceae	201174|Actinobacteria	L	ATP-dependent DNA helicase	pcrA	GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1157956_1	930169.B5T_00878	8.67e-103	316.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,1XHJP@135619|Oceanospirillales	135619|Oceanospirillales	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_1804821_1	1386089.N865_05930	1.62e-71	233.0	COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria,4FF8U@85021|Intrasporangiaceae	201174|Actinobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1458512_1	1500894.JQNN01000001_gene3222	2.79e-39	143.0	COG3735@1|root,COG3735@2|Bacteria,1NARA@1224|Proteobacteria	1224|Proteobacteria	S	TraB family	-	-	-	-	-	-	-	-	-	-	-	-	TraB
k59_1804836_1	686340.Metal_1052	1.27e-127	374.0	COG5520@1|root,COG5520@2|Bacteria,1N9T9@1224|Proteobacteria,1RP92@1236|Gammaproteobacteria,1XG0W@135618|Methylococcales	135618|Methylococcales	M	Belongs to the glycosyl hydrolase 30 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_30,Glyco_hydro_30C
k59_870973_1	543728.Vapar_3404	1.98e-39	150.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,2VHKP@28216|Betaproteobacteria,4AA8Y@80864|Comamonadaceae	28216|Betaproteobacteria	S	DNA internalization-related competence protein ComEC Rec2	comA	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_1574502_1	78346.BRUM_1444	4.72e-11	67.8	COG0747@1|root,COG0747@2|Bacteria,2GM5G@201174|Actinobacteria,4CYUZ@85004|Bifidobacteriales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_634551_2	713586.KB900536_gene2980	4.24e-81	252.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1WWGS@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	-	-	ko:K10764	ko00270,ko00920,ko01100,map00270,map00920,map01100	-	R01288	RC00020,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_802565_1	1386089.N865_07540	3.28e-204	597.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4FIMQ@85021|Intrasporangiaceae	201174|Actinobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_802565_2	1304865.JAGF01000001_gene3846	1.42e-159	461.0	COG0552@1|root,COG0552@2|Bacteria,2GJQH@201174|Actinobacteria,4F1S4@85016|Cellulomonadaceae	201174|Actinobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
k59_1458527_1	1267005.KB911258_gene91	4.21e-107	316.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2TTQC@28211|Alphaproteobacteria,3N6H0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluC	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_1574505_1	1094508.Tsac_0989	0.00014	48.9	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,42ETH@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_1574505_2	323261.Noc_2249	7.5e-81	254.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1WW6E@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
k59_753609_1	1123368.AUIS01000031_gene1420	5.88e-79	255.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,2NE68@225057|Acidithiobacillales	225057|Acidithiobacillales	P	STAS domain	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1574507_1	1286106.MPL1_10222	8.07e-21	91.3	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,1RQ65@1236|Gammaproteobacteria,45ZMX@72273|Thiotrichales	72273|Thiotrichales	O	FeS assembly protein SufB	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_1574507_2	1396141.BATP01000032_gene4357	6.61e-20	85.1	COG0735@1|root,COG0735@2|Bacteria,46W8N@74201|Verrucomicrobia,2IUJS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Ferric uptake regulator family	-	-	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_1632663_1	1049564.TevJSym_ao00750	6.25e-89	271.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,1J52U@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	COG1077 Actin-like ATPase involved in cell morphogenesis	mreB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_166645_1	243233.MCA0087	3.85e-38	145.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1XDKW@135618|Methylococcales	135618|Methylococcales	NU	Neisseria PilC beta-propeller domain	-	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
k59_1574522_1	380394.Lferr_0673	1.16e-12	63.2	29X7Q@1|root,30IWY@2|Bacteria,1PJW6@1224|Proteobacteria,1T98V@1236|Gammaproteobacteria,2NE1D@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
k59_1574522_2	768671.ThimaDRAFT_4374	1.63e-24	95.5	COG1396@1|root,COG1396@2|Bacteria,1NJTM@1224|Proteobacteria	1224|Proteobacteria	K	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
k59_342374_2	979556.MTES_2077	3.05e-24	103.0	COG3345@1|root,COG3345@2|Bacteria,2GJJ1@201174|Actinobacteria,4FKWH@85023|Microbacteriaceae	201174|Actinobacteria	G	Melibiase	rafA	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
k59_471559_1	1394178.AWOO02000009_gene4318	7.96e-19	88.6	COG0614@1|root,COG0614@2|Bacteria,2GM6R@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Fe3 -hydroxamate transport system, periplasmic component	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
k59_999833_1	1280692.AUJL01000027_gene2121	4.29e-44	159.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,36F3D@31979|Clostridiaceae	186801|Clostridia	S	CBS domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_412778_1	1121405.dsmv_2731	1.23e-153	446.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,42MUW@68525|delta/epsilon subdivisions,2WIXI@28221|Deltaproteobacteria,2MHW6@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_295470_1	706587.Desti_3053	3.22e-97	308.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MQB9@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_471564_1	887929.HMP0721_1063	6.95e-17	83.2	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,25VJN@186806|Eubacteriaceae	186801|Clostridia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_471564_2	1191523.MROS_0316	2.48e-07	54.7	COG0472@1|root,COG0472@2|Bacteria	2|Bacteria	M	phospho-N-acetylmuramoyl-pentapeptide-transferase activity	mraY	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105	Glycos_transf_4,MraY_sig1
k59_1234801_1	395493.BegalDRAFT_2934	4.51e-103	327.0	COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Acyl-CoA synthetase (NDP forming)	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_2638_1	572477.Alvin_0471	1.25e-14	75.5	2E6TU@1|root,331DN@2|Bacteria,1NBK8@1224|Proteobacteria,1SG0X@1236|Gammaproteobacteria,1WZEV@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_178051_1	515635.Dtur_0978	1.14e-56	196.0	COG0480@1|root,COG0480@2|Bacteria	2|Bacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1586754_2	1123392.AQWL01000001_gene1517	4.18e-45	149.0	COG2920@1|root,COG2920@2|Bacteria,1N6BU@1224|Proteobacteria,2WC7H@28216|Betaproteobacteria,1KT76@119069|Hydrogenophilales	119069|Hydrogenophilales	P	DsrC like protein	-	-	-	-	-	-	-	-	-	-	-	-	DsrC
k59_1352114_1	1049564.TevJSym_aj00120	2.52e-40	146.0	COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,1S6AN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KT	phosphohydrolase	rela3	-	-	-	-	-	-	-	-	-	-	-	HD_4
k59_589029_1	880072.Desac_0511	3.16e-30	123.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,42RXF@68525|delta/epsilon subdivisions,2WNF1@28221|Deltaproteobacteria,2MRN8@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase, family 39	arnT	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
k59_61820_1	1157637.KB892094_gene2918	1.29e-93	299.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria	201174|Actinobacteria	M	Exporter of polyketide	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
k59_237100_1	765420.OSCT_3225	0.000515	43.9	COG0285@1|root,COG0285@2|Bacteria,2G64M@200795|Chloroflexi,37568@32061|Chloroflexia	32061|Chloroflexia	H	PFAM cytoplasmic peptidoglycan synthetase domain protein	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_883687_1	457412.RSAG_00167	8.07e-05	46.2	COG0263@1|root,COG0263@2|Bacteria,1TPG6@1239|Firmicutes,2486P@186801|Clostridia,3WGZ7@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
k59_1704379_1	243233.MCA1608	5.73e-29	118.0	COG2251@1|root,COG2251@2|Bacteria,1QUUG@1224|Proteobacteria,1T3FR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function(DUF2779)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2779
k59_355280_1	402881.Plav_0507	7.75e-73	229.0	COG5309@1|root,COG5309@2|Bacteria	2|Bacteria	G	chondroitin AC lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1294603_1	367299.JOEE01000003_gene2823	3.77e-101	299.0	COG2180@1|root,COG2180@2|Bacteria,2IAQV@201174|Actinobacteria,4FF4E@85021|Intrasporangiaceae	201174|Actinobacteria	C	Nitrate reductase	narJ	-	-	ko:K00373	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Nitrate_red_del
k59_1352120_1	1126627.BAWE01000005_gene6111	1.08e-39	154.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_1704381_1	379731.PST_4002	4.07e-54	176.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria,1YZWH@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO0053,iSDY_1059.SDY_4064	CTP_transf_like
k59_2649_1	471853.Bcav_1330	6.77e-18	87.8	COG2268@1|root,COG3599@1|root,COG2268@2|Bacteria,COG3599@2|Bacteria,2GKTJ@201174|Actinobacteria	201174|Actinobacteria	D	Cellulose-binding protein	abpS	-	-	-	-	-	-	-	-	-	-	-	DivIVA
k59_2649_2	743718.Isova_0181	3.3e-45	151.0	2EDGM@1|root,32US9@2|Bacteria,2I8AA@201174|Actinobacteria,4F4ZW@85017|Promicromonosporaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_237109_1	471874.PROSTU_04646	3.75e-12	68.6	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria,3Z886@586|Providencia	1236|Gammaproteobacteria	T	Phosphate regulon sensor protein	phoR	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016036,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0035556,GO:0036211,GO:0042578,GO:0042594,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071496,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3329,HATPase_c,HisKA,PAS,PAS_8
k59_237109_2	1122603.ATVI01000007_gene1582	7.41e-40	138.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,1X316@135614|Xanthomonadales	135614|Xanthomonadales	KT	Two component response regulator for the phosphate regulon	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_61833_1	1122201.AUAZ01000004_gene3394	4.81e-84	269.0	COG0732@1|root,COG5113@1|root,COG0732@2|Bacteria,COG3236@2|Bacteria,1Q4FB@1224|Proteobacteria,1RS7D@1236|Gammaproteobacteria,46823@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	restriction modification system DNA specificity	hsdS	-	3.1.21.3	ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
k59_1294614_2	1049564.TevJSym_by00060	3.58e-05	44.3	2E7PJ@1|root,33255@2|Bacteria,1NANJ@1224|Proteobacteria,1SDCV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1586769_1	1125863.JAFN01000001_gene825	9.62e-58	192.0	arCOG09742@1|root,2ZBGR@2|Bacteria,1R9H3@1224|Proteobacteria,42XHN@68525|delta/epsilon subdivisions,2WT8H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_999858_1	349124.Hhal_2308	7.49e-20	87.4	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria,1WY3H@135613|Chromatiales	135613|Chromatiales	L	Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle	-	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
k59_999858_2	1123517.JOMR01000001_gene411	3.42e-20	85.5	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria,460XS@72273|Thiotrichales	72273|Thiotrichales	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_178071_1	1448389.BAVQ01000038_gene1963	7.47e-70	237.0	COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,2GISC@201174|Actinobacteria	201174|Actinobacteria	L	helicase	helZ	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
k59_1528129_1	1307759.JOMJ01000004_gene2546	2.08e-20	99.4	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42PQZ@68525|delta/epsilon subdivisions,2WMD9@28221|Deltaproteobacteria,2M8AQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Hemolysin-type calcium-binding region	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,HCBP_related,He_PIG,HemolysinCabind,Peptidase_M91,VWA,VWA_2
k59_1528129_2	1266909.AUAG01000001_gene1592	8.49e-22	97.4	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,1RNK4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Type I secretion membrane fusion protein, HlyD	hlyD	-	-	ko:K11003	ko03070,ko05133,map03070,map05133	M00325,M00575	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	8.A.1.3.1,8.A.1.3.2	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
k59_1294622_1	935839.JAGJ01000006_gene3452	3.08e-39	135.0	COG4420@1|root,COG4420@2|Bacteria,2GJRV@201174|Actinobacteria,4F4DR@85017|Promicromonosporaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
k59_1410864_1	1487923.DP73_07440	9.86e-76	255.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,25ZY7@186807|Peptococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_1234839_1	1394178.AWOO02000020_gene7377	5.94e-85	259.0	COG0491@1|root,COG0491@2|Bacteria,2I9GW@201174|Actinobacteria,4EGY5@85012|Streptosporangiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1117270_1	864051.BurJ1DRAFT_1565	6.44e-79	248.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2VI9P@28216|Betaproteobacteria,1KJU9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_883717_1	1123065.ATWL01000001_gene260	3.8e-132	382.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria	201174|Actinobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_883717_2	446466.Cfla_1843	8.28e-240	668.0	COG0044@1|root,COG0044@2|Bacteria,2GJ0T@201174|Actinobacteria,4F1Q0@85016|Cellulomonadaceae	201174|Actinobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_883717_3	446471.Xcel_1711	5.76e-39	140.0	COG0505@1|root,COG0505@2|Bacteria,2GKFA@201174|Actinobacteria,4F3DQ@85017|Promicromonosporaceae	201174|Actinobacteria	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1383	CPSase_sm_chain,GATase
k59_119464_1	460265.Mnod_2710	1.23e-82	258.0	COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MXPX@1224|Proteobacteria,2U6TX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Oxidoreductase FAD-binding domain	-	-	1.18.1.3	ko:K15765	ko00623,ko00920,ko01100,ko01120,ko01220,map00623,map00920,map01100,map01120,map01220	M00538	R02550,R03562,R05666,R09513	RC00269,RC00490,RC02556	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
k59_471612_1	446466.Cfla_3445	1.16e-156	466.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4F0GR@85016|Cellulomonadaceae	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_1822912_1	1121033.AUCF01000021_gene2825	1.38e-52	177.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TUHD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
k59_706478_1	1304865.JAGF01000001_gene119	2.96e-44	163.0	COG1409@1|root,COG3291@1|root,COG1409@2|Bacteria,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria	201174|Actinobacteria	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,PKD
k59_1469592_1	1249627.D779_2144	4.51e-107	316.0	COG2221@1|root,COG2221@2|Bacteria,1MVZQ@1224|Proteobacteria,1RQXZ@1236|Gammaproteobacteria,1WWM7@135613|Chromatiales	135613|Chromatiales	C	reductase, dissimilatory-type beta subunit	dsrB	-	1.8.99.5	ko:K11181	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_1294651_1	525268.HMPREF0308_0996	2.38e-65	219.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,22KHA@1653|Corynebacteriaceae	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_589076_1	156889.Mmc1_0520	3.37e-34	130.0	COG5607@1|root,COG5607@2|Bacteria,1QTX6@1224|Proteobacteria,2TWMZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM CHAD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
k59_1586794_1	399795.CtesDRAFT_PD2205	1.37e-48	174.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,4AAP4@80864|Comamonadaceae	28216|Betaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_1586794_2	754477.Q7C_223	6.99e-21	90.9	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,45ZP1@72273|Thiotrichales	72273|Thiotrichales	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
k59_237145_1	566466.NOR53_2438	1.09e-69	224.0	COG3659@1|root,COG3659@2|Bacteria,1R8TI@1224|Proteobacteria,1S21B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Carbohydrate-selective porin OprB	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB
k59_530382_1	670307.HYPDE_39428	1.11e-11	62.8	2C2M3@1|root,316DE@2|Bacteria,1R7TZ@1224|Proteobacteria,2UE3W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_471627_1	1454004.AW11_02488	7.23e-79	250.0	COG0394@1|root,COG0704@1|root,COG0394@2|Bacteria,COG0704@2|Bacteria	2|Bacteria	P	negative regulation of phosphate transmembrane transport	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	1.20.4.1,3.1.3.48	ko:K01104,ko:K02039,ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	PhoU
k59_647797_1	330214.NIDE1438	9.71e-79	244.0	COG3000@1|root,COG3000@2|Bacteria	2|Bacteria	I	iron ion binding	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_355345_1	420324.KI911934_gene172	1.7e-78	245.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JXEF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_883738_1	765911.Thivi_1369	4.57e-115	342.0	2DB7K@1|root,2Z7MK@2|Bacteria,1NQT5@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF1576)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1576
k59_942486_1	290400.Jann_1122	2.13e-75	234.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2U23D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_589082_1	1304877.KI519400_gene1090	4.04e-102	319.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2TQYD@28211|Alphaproteobacteria,3JSX5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Catalytic subunit of the nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC. Essential function for nitrate assimilation and may have a role in anaerobic metabolism	napA	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0048037,GO:0051536,GO:0051540,GO:0055114	-	ko:K00372,ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530,M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_999887_1	1121335.Clst_0958	2.44e-82	249.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,3WHG1@541000|Ruminococcaceae	186801|Clostridia	E	ABC transporter, ATP-binding protein	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_706517_1	517417.Cpar_2001	7.16e-14	71.2	COG0344@1|root,COG0344@2|Bacteria,1FDRT@1090|Chlorobi	1090|Chlorobi	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
k59_706517_2	335543.Sfum_2529	7.03e-13	68.9	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,42TMM@68525|delta/epsilon subdivisions,2WQ6S@28221|Deltaproteobacteria,2MRXS@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
k59_2727_1	196490.AUEZ01000007_gene5080	2.7e-83	261.0	COG0598@1|root,COG0598@2|Bacteria,1MWMP@1224|Proteobacteria,2TQQD@28211|Alphaproteobacteria,3JTS3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	CorA-like Mg2+ transporter protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_295566_1	367299.JOEE01000003_gene2920	2.63e-95	309.0	COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4FG36@85021|Intrasporangiaceae	201174|Actinobacteria	E	Dehydrogenase	gdh	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
k59_530409_1	631362.Thi970DRAFT_00753	3.62e-39	142.0	28KQH@1|root,2ZA8A@2|Bacteria,1R5EQ@1224|Proteobacteria,1RRD9@1236|Gammaproteobacteria,1WXTM@135613|Chromatiales	135613|Chromatiales	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
k59_530409_2	765911.Thivi_2391	3.85e-16	77.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,1RSEQ@1236|Gammaproteobacteria,1WXQW@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR_N,TPP_enzyme_C
k59_471653_1	7213.XP_004528652.1	3.32e-19	84.7	COG0289@1|root,2S0IY@2759|Eukaryota,3AEPI@33154|Opisthokonta,3BYU3@33208|Metazoa,3DERJ@33213|Bilateria,4224G@6656|Arthropoda,3SP5D@50557|Insecta	33208|Metazoa	E	Dihydrodipicolinate reductase, N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	DapB_C,DapB_N
k59_471653_2	1056820.KB900653_gene3094	9.81e-22	93.6	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,1RNH3@1236|Gammaproteobacteria,2PMNH@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	I	Acyl transferase domain	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iEcE24377_1341.EcE24377A_1213,iJN746.PP_1913,iPC815.YPO1598	Acyl_transf_1
k59_355382_1	1117647.M5M_01585	2.24e-104	318.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,1J589@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	actP	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_1704451_1	566466.NOR53_3227	5.71e-49	170.0	COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,1RPTU@1236|Gammaproteobacteria,1J804@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_412871_1	570952.ATVH01000018_gene3176	2.94e-47	173.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,2TRWD@28211|Alphaproteobacteria,2JPPU@204441|Rhodospirillales	204441|Rhodospirillales	M	Surface antigen	-	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA
k59_1117308_1	1403819.BATR01000027_gene909	2.99e-76	261.0	COG0515@1|root,COG0515@2|Bacteria,46X96@74201|Verrucomicrobia,2IV2P@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KLT	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_823757_2	471853.Bcav_1165	4.15e-140	407.0	COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria	201174|Actinobacteria	K	cell envelope-related transcriptional attenuator	lytR2	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
k59_823757_3	1303692.SFUL_836	8.62e-47	155.0	COG1832@1|root,COG1832@2|Bacteria,2IHSP@201174|Actinobacteria	201174|Actinobacteria	S	CoA-binding	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
k59_119516_1	1123392.AQWL01000001_gene1317	1.49e-36	135.0	COG1524@1|root,COG1524@2|Bacteria,1PGPZ@1224|Proteobacteria,2VPTA@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PglZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PglZ
k59_119516_2	246195.DNO_0175	6.26e-75	229.0	28JVR@1|root,2Z9KN@2|Bacteria,1R7WT@1224|Proteobacteria,1S314@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1822975_1	215803.DB30_6012	8.08e-09	58.5	COG1716@1|root,COG1716@2|Bacteria,1Q294@1224|Proteobacteria,437WA@68525|delta/epsilon subdivisions,2X35X@28221|Deltaproteobacteria,2Z0BQ@29|Myxococcales	28221|Deltaproteobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
k59_765044_1	323850.Shew_0984	2.28e-93	288.0	COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,1SWQX@1236|Gammaproteobacteria,2QCYP@267890|Shewanellaceae	1236|Gammaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1824363_1	396588.Tgr7_0006	8.6e-91	286.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1WW1J@135613|Chromatiales	135613|Chromatiales	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	-	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_179128_2	351348.Maqu_0609	1.94e-94	291.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW8A@1224|Proteobacteria,1RRNV@1236|Gammaproteobacteria,46D6X@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_29,HTH_32,HTH_33
k59_648763_1	1089545.KB913037_gene1102	5.94e-06	49.7	COG1139@1|root,COG1139@2|Bacteria,2GJDR@201174|Actinobacteria,4DZA8@85010|Pseudonocardiales	201174|Actinobacteria	C	(4Fe-4S) cluster-containing protein	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
k59_648763_2	446471.Xcel_0891	3.08e-37	133.0	COG0247@1|root,COG0247@2|Bacteria,2GIVX@201174|Actinobacteria,4F360@85017|Promicromonosporaceae	201174|Actinobacteria	C	Cysteine-rich domain	lutA	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
k59_4058_1	1121403.AUCV01000005_gene345	5.93e-49	174.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2MIU8@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_1296229_1	96561.Dole_0966	1.25e-84	265.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2WJ6D@28221|Deltaproteobacteria,2MJ7G@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
k59_707580_1	1260251.SPISAL_05925	2.53e-14	73.9	COG4544@1|root,COG4544@2|Bacteria,1MZQU@1224|Proteobacteria,1S9RP@1236|Gammaproteobacteria,1WZQP@135613|Chromatiales	135613|Chromatiales	D	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division	-	-	-	ko:K14160	-	-	-	-	ko00000,ko03400	-	-	-	SulA
k59_707580_2	1249634.D781_4192	1.05e-30	114.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria,400DF@613|Serratia	1236|Gammaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_1824384_1	1121035.AUCH01000013_gene3123	6.82e-08	55.1	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,2VJZJ@28216|Betaproteobacteria,2KUDZ@206389|Rhodocyclales	206389|Rhodocyclales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
k59_1824384_2	521719.ATXQ01000012_gene1621	1.39e-07	56.6	COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1YEH3@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfC	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0055114	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB
k59_130373_1	926564.KI911766_gene4642	7.15e-86	265.0	COG0148@1|root,COG0148@2|Bacteria,2GJAY@201174|Actinobacteria,4F3KS@85017|Promicromonosporaceae	201174|Actinobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_957541_1	2340.JV46_03040	3.35e-78	241.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,1J53F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the ribose of guanosine 2251 in 23S rRNA	rlmB	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
k59_658703_1	1123065.ATWL01000004_gene2919	1.61e-188	568.0	COG1643@1|root,COG1643@2|Bacteria,2GIWX@201174|Actinobacteria	201174|Actinobacteria	L	ATP-dependent helicase	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_1073650_1	1121405.dsmv_0671	1.51e-63	200.0	COG1268@1|root,COG1268@2|Bacteria,1RH78@1224|Proteobacteria,42RTB@68525|delta/epsilon subdivisions,2WNS7@28221|Deltaproteobacteria,2MK04@213118|Desulfobacterales	28221|Deltaproteobacteria	S	BioY family	-	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
k59_370272_1	396588.Tgr7_0522	3.2e-95	289.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1WXFU@135613|Chromatiales	135613|Chromatiales	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_370272_2	765913.ThidrDRAFT_1715	4.78e-16	77.8	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1WX0A@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_1837927_1	91464.S7335_5034	1.87e-26	103.0	COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria,1GYT4@1129|Synechococcus	1117|Cyanobacteria	C	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_1248745_1	1121918.ARWE01000001_gene3354	1.99e-192	566.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42PMK@68525|delta/epsilon subdivisions,2WTI2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Domain of unknown function (DUF1974)	-	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_1248745_2	929712.KI912613_gene2231	1.34e-09	58.5	COG0637@1|root,COG0637@2|Bacteria,2GMIQ@201174|Actinobacteria,4CTFR@84995|Rubrobacteria	84995|Rubrobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_898540_1	710696.Intca_3112	4.23e-17	80.1	COG3547@1|root,COG3547@2|Bacteria,2IBF5@201174|Actinobacteria	201174|Actinobacteria	L	Transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1538507_1	1136417.AZWE01000077_gene274	1.6e-71	233.0	COG3464@1|root,COG3464@2|Bacteria,2GJK7@201174|Actinobacteria,4DE6S@85008|Micromonosporales	201174|Actinobacteria	L	Helix-turn-helix domain of transposase family ISL3	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_717321_1	1134912.AJTV01000023_gene2878	2.35e-53	184.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria,36Y6U@31993|Methylocystaceae	28211|Alphaproteobacteria	MU	Outer membrane efflux protein	oprN	-	-	ko:K18300,ko:K19593	-	M00641,M00769	-	-	ko00000,ko00002,ko01504,ko02000	1.B.17,2.A.6.2.34	-	-	OEP
k59_1538512_1	1267005.KB911257_gene715	1.07e-54	186.0	COG0642@1|root,COG0642@2|Bacteria,1QU3Y@1224|Proteobacteria,2TVYH@28211|Alphaproteobacteria,3N9IC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	regB	-	2.7.13.3	ko:K15011	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_76766_2	1122239.AULS01000005_gene1254	4.21e-20	90.1	COG0582@1|root,COG0582@2|Bacteria,2GISN@201174|Actinobacteria,4FN7F@85023|Microbacteriaceae	201174|Actinobacteria	L	Phage integrase family	int8	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
k59_1073669_1	367299.JOEE01000008_gene522	1.15e-86	275.0	COG0480@1|root,COG0480@2|Bacteria,2GKRU@201174|Actinobacteria,4FEAE@85021|Intrasporangiaceae	201174|Actinobacteria	J	elongation factor G	fusA2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_189041_1	1313301.AUGC01000006_gene42	2.59e-23	100.0	COG0052@1|root,COG0052@2|Bacteria,4NER0@976|Bacteroidetes	976|Bacteroidetes	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_305867_1	610130.Closa_2776	4.64e-23	101.0	COG5316@1|root,COG5316@2|Bacteria,1TY9F@1239|Firmicutes,24DJ2@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_599179_1	1249627.D779_1826	1.31e-110	347.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WXV4@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_482089_1	631362.Thi970DRAFT_00472	1.48e-19	87.8	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RPM1@1236|Gammaproteobacteria,1WW4Q@135613|Chromatiales	135613|Chromatiales	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_424244_1	935839.JAGJ01000010_gene352	4.43e-99	297.0	COG2171@1|root,COG2171@2|Bacteria,2GIZ9@201174|Actinobacteria,4F42J@85017|Promicromonosporaceae	201174|Actinobacteria	H	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA	dapD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008666,GO:0016020,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0030312,GO:0031402,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0071944	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1201c	Hexapep_2,THDPS_M
k59_1075437_1	1161401.ASJA01000003_gene2810	5.51e-74	232.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,43WRP@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	Transketolase, pyrimidine binding domain	bkdA2	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_958864_1	717785.HYPMC_2110	1.57e-95	285.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2TQQ5@28211|Alphaproteobacteria,3N664@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	serine acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
k59_1075438_1	367299.JOEE01000004_gene1371	2.45e-70	222.0	COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria,4FGBX@85021|Intrasporangiaceae	201174|Actinobacteria	T	DNA-binding protein	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
k59_424246_1	518766.Rmar_0923	7.85e-43	155.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,4NFHX@976|Bacteroidetes,1FIM5@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	EI	ArgK protein	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_424246_2	1121405.dsmv_0419	1.67e-55	179.0	COG1309@1|root,COG1309@2|Bacteria,1R4VA@1224|Proteobacteria,42PZX@68525|delta/epsilon subdivisions,2WK4I@28221|Deltaproteobacteria,2MI67@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1773791_1	713586.KB900536_gene433	5.08e-38	131.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1WVXA@135613|Chromatiales	135613|Chromatiales	K	Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins	-	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
k59_1363453_1	670307.HYPDE_31238	0.000475	40.8	COG2154@1|root,COG2154@2|Bacteria,1RIEN@1224|Proteobacteria,2U9EC@28211|Alphaproteobacteria,3N7EB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
k59_1363453_2	717785.HYPMC_1630	7.13e-111	332.0	COG1907@1|root,COG1907@2|Bacteria,1MWHM@1224|Proteobacteria,2U1RC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TIGRFAM beta-ribofuranosylaminobenzene 5'-phosphate synthase family	mptG	-	-	-	-	-	-	-	-	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_1363453_3	717785.HYPMC_1629	7.97e-24	97.4	COG0373@1|root,COG0373@2|Bacteria,1MXX5@1224|Proteobacteria,2U1CR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal	-	-	-	ko:K10714	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R08059	RC00202	ko00000,ko00001,ko01000	-	-	-	Mpt_N
k59_718269_1	1029823.AFIE01000001_gene2103	8.54e-165	474.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPDE@1236|Gammaproteobacteria,3NJ0S@468|Moraxellaceae	1236|Gammaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_1715336_1	396588.Tgr7_2622	1.46e-108	333.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales	135613|Chromatiales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_1839242_1	1151116.Q7S_08945	5.41e-10	66.2	COG0477@1|root,COG0477@2|Bacteria,1MX9T@1224|Proteobacteria,1RP8A@1236|Gammaproteobacteria,3FF69@34037|Rahnella	1236|Gammaproteobacteria	EGP	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1250099_3	335283.Neut_1684	3.15e-85	268.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2VJEQ@28216|Betaproteobacteria,372MX@32003|Nitrosomonadales	28216|Betaproteobacteria	G	BT1 family	-	-	-	-	-	-	-	-	-	-	-	-	BT1
k59_371623_1	765911.Thivi_4354	3.67e-205	605.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1WX8F@135613|Chromatiales	135613|Chromatiales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_306766_1	519989.ECTPHS_09974	4.32e-140	414.0	COG2170@1|root,COG2170@2|Bacteria,1MXET@1224|Proteobacteria,1RPKZ@1236|Gammaproteobacteria,1WWXK@135613|Chromatiales	135613|Chromatiales	S	glutamate--cysteine ligase	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
k59_1311046_1	1396141.BATP01000056_gene3201	1.55e-48	176.0	COG1404@1|root,COG3210@1|root,COG4412@1|root,COG5492@1|root,COG1404@2|Bacteria,COG3210@2|Bacteria,COG4412@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Peptidase_S8,fn3
k59_600083_1	877418.ATWV01000002_gene1103	1.88e-09	60.5	COG0664@1|root,COG0664@2|Bacteria,2J8WG@203691|Spirochaetes	203691|Spirochaetes	T	Cyclic nucleotide binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_424258_1	710687.KI912270_gene2423	1.54e-102	315.0	COG4974@1|root,COG4974@2|Bacteria,2IBD6@201174|Actinobacteria,236NP@1762|Mycobacteriaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
k59_1250105_1	907348.TresaDRAFT_1388	1.25e-06	52.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	FHA
k59_1250105_2	485916.Dtox_4297	1.21e-74	228.0	COG0454@1|root,COG0456@2|Bacteria,1VW2R@1239|Firmicutes	1239|Firmicutes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
k59_131401_1	266117.Rxyl_2410	5.35e-69	229.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria,4CPCB@84995|Rubrobacteria	84995|Rubrobacteria	EQ	Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k59_1657917_1	396588.Tgr7_0975	3.12e-66	212.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1WXI6@135613|Chromatiales	135613|Chromatiales	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_306776_1	472759.Nhal_1520	2.31e-18	88.2	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,1WZX0@135613|Chromatiales	135613|Chromatiales	Q	PFAM multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
k59_1009399_1	345341.KUTG_02461	6.23e-60	191.0	2CB46@1|root,31GHU@2|Bacteria,2ID3Z@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4194)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4194
k59_1009399_2	85643.Tmz1t_0051	2.19e-53	189.0	COG4913@1|root,COG4913@2|Bacteria,1N16Z@1224|Proteobacteria,2VJD2@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SbcCD_C
k59_774442_1	1267535.KB906767_gene3396	1.79e-117	344.0	COG4447@1|root,COG4447@2|Bacteria,3Y3TM@57723|Acidobacteria,2JHSZ@204432|Acidobacteriia	204432|Acidobacteriia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
k59_1311062_2	1043493.BBLU01000002_gene1760	1.92e-11	63.2	arCOG07533@1|root,2ZF5I@2|Bacteria,2IMPX@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
k59_256046_1	518766.Rmar_0342	6.03e-80	259.0	COG0209@1|root,COG0209@2|Bacteria,4NEHQ@976|Bacteroidetes,1FJVJ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrd	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
k59_371650_1	106370.Francci3_0319	2.34e-50	178.0	COG1807@1|root,COG1807@2|Bacteria,2GJPU@201174|Actinobacteria,4EUST@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase, family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_483057_2	218140.BPSY_1116	7.34e-18	82.8	COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria,4CZ8Y@85004|Bifidobacteriales	201174|Actinobacteria	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10548	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.5	-	-	ABC_tran
k59_958919_1	1280001.BAOA01000136_gene1956	8.05e-28	113.0	COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1N6EM@1224|Proteobacteria,1SBXG@1236|Gammaproteobacteria,1XU00@135623|Vibrionales	135623|Vibrionales	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OMP_b-brl,OmpA,OmpA_membrane
k59_1075513_1	1116472.MGMO_84c00070	7.79e-63	204.0	COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria,1S58J@1236|Gammaproteobacteria,1XG72@135618|Methylococcales	135618|Methylococcales	D	Cellulose biosynthesis protein BcsQ	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
k59_1075513_2	572477.Alvin_1845	1.57e-29	107.0	COG2932@1|root,COG2932@2|Bacteria,1NBZE@1224|Proteobacteria,1S6MQ@1236|Gammaproteobacteria,1WYPT@135613|Chromatiales	135613|Chromatiales	K	Peptidase S24-like	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S24
k59_131423_1	525897.Dbac_0271	5.88e-113	338.0	COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,42M60@68525|delta/epsilon subdivisions,2WITJ@28221|Deltaproteobacteria,2M9R3@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	dsrK	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_1311090_1	396588.Tgr7_2124	6.7e-10	65.5	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1WWH2@135613|Chromatiales	135613|Chromatiales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1485168_1	1341646.CBMO010000059_gene1669	8.26e-72	243.0	COG1524@1|root,COG1524@2|Bacteria,2GK2R@201174|Actinobacteria,236VU@1762|Mycobacteriaceae	201174|Actinobacteria	S	PglZ domain	pglZ	-	-	-	-	-	-	-	-	-	-	-	PglZ
k59_1597854_1	765911.Thivi_0023	4.08e-44	150.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,1WX8U@135613|Chromatiales	135613|Chromatiales	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
k59_1597854_2	911239.CF149_18036	2.64e-11	63.5	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043170,GO:0044425,GO:0044459,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901564	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_541864_1	582899.Hden_0950	1.64e-281	805.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS2I@28211|Alphaproteobacteria,3N67W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
k59_131443_1	765910.MARPU_04245	3.6e-69	220.0	COG0583@1|root,COG0583@2|Bacteria,1MVHT@1224|Proteobacteria,1RN7G@1236|Gammaproteobacteria,1WXTT@135613|Chromatiales	135613|Chromatiales	K	PFAM HTH transcriptional regulator, LysR	-	-	-	ko:K03717	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_1127028_1	1205908.AKXW01000045_gene3577	2.02e-34	125.0	COG4902@1|root,COG4902@2|Bacteria,1RHUF@1224|Proteobacteria,1S5D0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein domain (DUF2202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2202
k59_256097_1	1476583.DEIPH_ctg018orf0023	4.25e-61	201.0	COG0025@1|root,COG0025@2|Bacteria,1WJH9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	COGs COG0025 NhaP-type Na H and K H antiporter	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
k59_1773851_1	658086.HMPREF0994_05935	2.05e-06	52.8	COG3837@1|root,COG3837@2|Bacteria,1V9M6@1239|Firmicutes,24HEN@186801|Clostridia	186801|Clostridia	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_424309_1	1246448.ANAZ01000042_gene1348	1.2e-89	281.0	COG0173@1|root,COG0173@2|Bacteria,2GJHU@201174|Actinobacteria,4EFGR@85012|Streptosporangiales	201174|Actinobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_1773853_1	1122603.ATVI01000007_gene1485	1.77e-08	56.2	COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,1S3XT@1236|Gammaproteobacteria,1X6G6@135614|Xanthomonadales	135614|Xanthomonadales	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_1773853_2	1123518.ARWI01000001_gene2385	2.18e-54	187.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,46011@72273|Thiotrichales	72273|Thiotrichales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_78134_1	228410.NE1874	2.79e-49	158.0	COG3411@1|root,COG3411@2|Bacteria,1MZR4@1224|Proteobacteria,2VTY1@28216|Betaproteobacteria,373AC@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Ferredoxin	fdx	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
k59_1250173_1	396588.Tgr7_1478	1.29e-103	326.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria,1WXMT@135613|Chromatiales	135613|Chromatiales	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1597861_1	768671.ThimaDRAFT_3731	2.9e-237	655.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,1RNQ4@1236|Gammaproteobacteria,1WXSS@135613|Chromatiales	135613|Chromatiales	C	Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1597861_2	88036.EFJ22464	1.69e-19	86.3	COG0627@1|root,KOG3101@2759|Eukaryota,37N8P@33090|Viridiplantae,3G94Q@35493|Streptophyta	35493|Streptophyta	S	Serine hydrolase involved in the detoxification of formaldehyde	-	GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0008150,GO:0010035,GO:0010038,GO:0016787,GO:0016788,GO:0016790,GO:0018738,GO:0042221,GO:0046686,GO:0048046,GO:0050896	3.1.2.12	ko:K01070	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R00527	RC00167,RC00320	ko00000,ko00001,ko01000	-	CE1	-	Esterase
k59_1127033_1	243233.MCA0364	4.2e-15	74.3	COG3009@1|root,COG3009@2|Bacteria,1N8BW@1224|Proteobacteria,1SHZZ@1236|Gammaproteobacteria,1XF9Y@135618|Methylococcales	135618|Methylococcales	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K09857	-	-	-	-	ko00000	-	-	-	ABC_trans_aux
k59_1127033_2	933262.AXAM01000106_gene2630	6.53e-106	323.0	COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,42PHS@68525|delta/epsilon subdivisions,2X5NU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	pqiB	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_190089_1	225849.swp_0931	2.2e-64	215.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,1RQK5@1236|Gammaproteobacteria,2QAED@267890|Shewanellaceae	1236|Gammaproteobacteria	C	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_190089_2	523791.Kkor_0771	3.13e-15	72.0	2EAIM@1|root,334MN@2|Bacteria,1N6XM@1224|Proteobacteria,1SF6C@1236|Gammaproteobacteria,1XKYG@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_190089_3	293614.A1C_02015	9.73e-08	57.8	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,2U1B0@28211|Alphaproteobacteria,47F9K@766|Rickettsiales	766|Rickettsiales	CP	COG0651 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	nuoL2	-	1.6.5.3	ko:K00341,ko:K05568	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M
k59_835500_1	326442.PSHAa1999	2.87e-39	145.0	COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,1RPTU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_1009443_1	1046724.KB889882_gene1832	6.49e-40	143.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,1RN71@1236|Gammaproteobacteria,4675T@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	molybdenum ABC transporter, periplasmic	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
k59_1009443_2	235985.BBPN01000055_gene7706	8.62e-10	58.9	COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria,2NI09@228398|Streptacidiphilus	201174|Actinobacteria	K	Uncharacterized ACR, COG1678	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_659762_1	1469245.JFBG01000066_gene132	1.23e-52	184.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1WX68@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_371728_1	1002339.HMPREF9373_1098	1.7e-09	62.8	COG1757@1|root,COG1757@2|Bacteria,1MVDF@1224|Proteobacteria,1RS40@1236|Gammaproteobacteria,3NSWH@468|Moraxellaceae	1236|Gammaproteobacteria	C	Na H antiporter	nhaC	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
k59_1311143_1	1198452.Jab_2c23190	4.81e-15	73.6	COG4544@1|root,COG4544@2|Bacteria,1MZQU@1224|Proteobacteria,2VUGI@28216|Betaproteobacteria,4749I@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division	imuA	-	-	ko:K14160	-	-	-	-	ko00000,ko03400	-	-	-	-
k59_256120_1	187272.Mlg_2254	1.75e-14	76.3	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1WX07@135613|Chromatiales	135613|Chromatiales	M	PFAM Cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_256120_2	684719.HIMB114_00005520	9.12e-05	48.5	COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,2TUX0@28211|Alphaproteobacteria,4BQK2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1365)	-	-	-	ko:K09701	-	-	-	-	ko00000	-	-	-	DUF1365
k59_1715416_1	1101190.ARWB01000001_gene903	4.73e-38	135.0	COG0791@1|root,COG0791@2|Bacteria,1RBV6@1224|Proteobacteria,2TVPH@28211|Alphaproteobacteria,3701I@31993|Methylocystaceae	28211|Alphaproteobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
k59_1721634_1	983917.RGE_31930	8.22e-116	343.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2VIWB@28216|Betaproteobacteria,1KK0W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	ccoN	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_1014514_1	911045.PSE_0310	1.16e-60	197.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2TRB4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_547617_1	414684.RC1_3841	1.47e-15	75.9	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2TSE3@28211|Alphaproteobacteria,2JQK0@204441|Rhodospirillales	204441|Rhodospirillales	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
k59_547617_2	1177154.Y5S_00538	2.16e-117	368.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1XJ50@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
k59_31235_1	710111.FraQA3DRAFT_4710	3.6e-14	78.6	COG2186@1|root,COG2186@2|Bacteria,2I9KG@201174|Actinobacteria	201174|Actinobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_1603734_1	331678.Cphamn1_0999	9.71e-19	89.4	COG0577@1|root,COG0577@2|Bacteria,1FDSK@1090|Chlorobi	1090|Chlorobi	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1603734_2	278957.ABEA03000126_gene3673	1.42e-26	103.0	COG1136@1|root,COG1136@2|Bacteria,46SI5@74201|Verrucomicrobia,3K7NZ@414999|Opitutae	414999|Opitutae	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_908507_1	861208.AGROH133_09853	1.49e-18	86.7	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,2TRM0@28211|Alphaproteobacteria,4BA55@82115|Rhizobiaceae	28211|Alphaproteobacteria	GM	dTDP-glucose 4-6-dehydratase	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_31238_1	1121405.dsmv_1871	5.61e-52	167.0	2CM87@1|root,32SDZ@2|Bacteria,1N0M3@1224|Proteobacteria,42UHD@68525|delta/epsilon subdivisions,2WQ5V@28221|Deltaproteobacteria,2MKHI@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1492436_1	1247649.D560_0985	1.62e-54	192.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,3T1BB@506|Alcaligenaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_547622_1	1298608.JCM18900_12690	1.16e-31	124.0	COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,1RQBF@1236|Gammaproteobacteria,3NK5B@468|Moraxellaceae	1236|Gammaproteobacteria	M	Belongs to the peptidase S11 family	pbpG	GO:0003674,GO:0003824,GO:0004175,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K07262	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
k59_1014520_1	589865.DaAHT2_2121	1.64e-124	375.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,42MV3@68525|delta/epsilon subdivisions,2WJZB@28221|Deltaproteobacteria,2MHKM@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM ATP-dependent DNA helicase, RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind,UvrD-helicase,UvrD_C
k59_1014520_2	1131553.JIBI01000017_gene577	4.78e-21	95.1	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2VJSI@28216|Betaproteobacteria,372PZ@32003|Nitrosomonadales	28216|Betaproteobacteria	L	RNA polymerase recycling family C-terminal	-	-	-	ko:K03580	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	DUF3883,Helicase_C,RapA_C,ResIII,SNF2_N
k59_313188_1	710685.MycrhN_0880	6.85e-57	199.0	COG1061@1|root,COG1112@1|root,COG1061@2|Bacteria,COG1112@2|Bacteria,2H3MV@201174|Actinobacteria,237MW@1762|Mycobacteriaceae	201174|Actinobacteria	KL	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,NERD,UvrD_C_2
k59_1369660_2	765912.Thimo_2335	2.02e-69	216.0	COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,1RNXI@1236|Gammaproteobacteria,1WWCR@135613|Chromatiales	135613|Chromatiales	K	response regulator receiver	-	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_1721646_2	1123065.ATWL01000013_gene1127	1.1e-142	416.0	COG1597@1|root,COG1597@2|Bacteria,2GJ3K@201174|Actinobacteria	201174|Actinobacteria	I	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
k59_1083757_1	396595.TK90_1989	5.25e-128	382.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1WW9V@135613|Chromatiales	135613|Chromatiales	J	TIGRFAM ribonuclease, Rne Rng family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_967465_1	1335757.SPICUR_09365	1.22e-56	184.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,1WY36@135613|Chromatiales	135613|Chromatiales	E	PFAM lipolytic protein G-D-S-L family	-	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
k59_841530_1	1304865.JAGF01000001_gene2501	3.87e-67	216.0	COG1653@1|root,COG1653@2|Bacteria,2GJIP@201174|Actinobacteria,4F1V3@85016|Cellulomonadaceae	201174|Actinobacteria	G	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K10240	ko02010,map02010	M00206	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.23	-	-	SBP_bac_8
k59_1603737_1	1246448.ANAZ01000029_gene4422	1.94e-06	52.0	COG0596@1|root,COG0596@2|Bacteria,2GM5K@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
k59_1664214_1	1144319.PMI16_00385	5.75e-14	77.8	COG0834@1|root,COG0834@2|Bacteria,1MXME@1224|Proteobacteria,2VHH1@28216|Betaproteobacteria,473FR@75682|Oxalobacteraceae	28216|Betaproteobacteria	ET	Periplasmic component of amino acid ABC-type transporter signal transduction system	fliY	-	-	ko:K02424	ko02010,map02010	M00234	-	-	ko00000,ko00001,ko00002,ko02000,ko02035	3.A.1.3.10,3.A.1.3.14	-	-	SBP_bac_3
k59_547633_1	933262.AXAM01000040_gene1233	3.71e-114	337.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2MI3G@213118|Desulfobacterales	28221|Deltaproteobacteria	T	response regulator receiver	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1083766_1	765911.Thivi_0537	6.39e-65	212.0	COG4782@1|root,COG4782@2|Bacteria,1MVAD@1224|Proteobacteria,1S13M@1236|Gammaproteobacteria,1WWSG@135613|Chromatiales	135613|Chromatiales	S	PFAM Alpha beta hydrolase of	-	-	-	-	-	-	-	-	-	-	-	-	DUF900
k59_1083766_2	768671.ThimaDRAFT_1050	2.41e-19	80.9	2ENM6@1|root,33G8J@2|Bacteria,1NI7V@1224|Proteobacteria,1SHH5@1236|Gammaproteobacteria,1WZNB@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1603739_1	225937.HP15_4138	1.27e-53	185.0	COG0277@1|root,COG0277@2|Bacteria,1MXTV@1224|Proteobacteria,1RRN8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG0277 FAD FMN-containing dehydrogenases	ygcU	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1721660_1	1304865.JAGF01000001_gene2082	2.07e-25	100.0	2CAW2@1|root,32RS7@2|Bacteria,2IB15@201174|Actinobacteria,4F18W@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1721660_2	1123065.ATWL01000005_gene1222	5.57e-28	110.0	COG2239@1|root,COG2239@2|Bacteria,2GMMK@201174|Actinobacteria	201174|Actinobacteria	P	transporter mgtE	mgtE	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE_N,PRC
k59_1492461_2	1211115.ALIQ01000228_gene1114	8.59e-74	224.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U6Z6@28211|Alphaproteobacteria,3NB93@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	[2Fe-2S] binding domain	MA20_17490	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_31276_1	765911.Thivi_3097	4.78e-95	307.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWJ6@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1014537_2	572477.Alvin_1022	2.85e-50	163.0	COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,1S8VU@1236|Gammaproteobacteria,1WYI6@135613|Chromatiales	135613|Chromatiales	J	Belongs to the HSP15 family	-	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
k59_1014537_3	697282.Mettu_0898	9.62e-12	61.6	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,1SCA2@1236|Gammaproteobacteria,1XFHQ@135618|Methylococcales	135618|Methylococcales	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	-	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
k59_1847912_1	76114.p2A146	5.4e-74	235.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2VK6J@28216|Betaproteobacteria,2KX2N@206389|Rhodocyclales	206389|Rhodocyclales	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1780161_1	42565.FP66_01250	1.85e-17	82.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1XHIG@135619|Oceanospirillales	135619|Oceanospirillales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1780161_2	96561.Dole_1563	6.91e-48	161.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,42N5B@68525|delta/epsilon subdivisions,2WJX4@28221|Deltaproteobacteria,2MIHZ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_1603748_1	1267535.KB906767_gene5326	1.86e-10	68.2	COG2010@1|root,COG2010@2|Bacteria,3Y650@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_CBB3,Paired_CXXCH_1
k59_1847915_1	999541.bgla_1g16560	1.69e-52	179.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2VHZV@28216|Betaproteobacteria,1KGJP@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Dehydrogenase	mdlB	-	1.1.99.31	ko:K15054	ko00627,ko01120,map00627,map01120	-	R04160,R07664	RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
k59_1847915_2	1040989.AWZU01000028_gene3006	4.83e-26	106.0	COG3573@1|root,COG3573@2|Bacteria,1MVX8@1224|Proteobacteria,2TVKJ@28211|Alphaproteobacteria,3JSJV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	FAD binding domain	MA20_22130	-	-	ko:K07077	-	-	-	-	ko00000	-	-	-	FAD_binding_2
k59_1545602_2	929703.KE386491_gene2187	8.57e-14	72.8	COG3752@1|root,COG3752@2|Bacteria,4NJXA@976|Bacteroidetes,47PJY@768503|Cytophagia	976|Bacteroidetes	S	3-oxo-5-alpha-steroid 4-dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
k59_1603754_1	1232410.KI421425_gene1549	2.51e-32	130.0	COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,43CT2@68525|delta/epsilon subdivisions,2X80K@28221|Deltaproteobacteria,43TUA@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
k59_1319779_1	1249627.D779_3611	4.12e-106	327.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1WWHQ@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_380299_1	765911.Thivi_1397	2.02e-89	289.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWJE@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1369700_1	402881.Plav_2318	8.59e-49	166.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,2TR8A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_31
k59_430349_1	266835.14028286	6.22e-27	102.0	COG5421@1|root,COG5421@2|Bacteria,1N03U@1224|Proteobacteria,2UCI1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3293 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2
k59_430349_2	1382303.JPOM01000001_gene2140	2.2e-59	186.0	COG3293@1|root,COG3293@2|Bacteria,1RM2E@1224|Proteobacteria,2UBEA@28211|Alphaproteobacteria,2KHCZ@204458|Caulobacterales	204458|Caulobacterales	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_430349_3	1381123.AYOD01000026_gene1481	5.09e-07	50.1	COG1585@1|root,COG1585@2|Bacteria,1N241@1224|Proteobacteria,2UC8X@28211|Alphaproteobacteria,43K81@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	OU	Membrane protein implicated in regulation of membrane protease activity	MA20_06475	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
k59_1721687_1	1249627.D779_3780	2.74e-17	85.5	COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,1RN89@1236|Gammaproteobacteria,1WWQS@135613|Chromatiales	135613|Chromatiales	Q	PFAM Mammalian cell entry related	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_380306_1	879212.DespoDRAFT_02754	1.25e-125	372.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42TZ6@68525|delta/epsilon subdivisions,2WQY3@28221|Deltaproteobacteria,2MN04@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_1369704_1	1042326.AZNV01000019_gene795	0.000568	48.1	COG0348@1|root,COG3901@1|root,COG0348@2|Bacteria,COG3901@2|Bacteria,1MY5M@1224|Proteobacteria,2TR0X@28211|Alphaproteobacteria,4BCBS@82115|Rhizobiaceae	28211|Alphaproteobacteria	CK	FMN_bind	nosR	-	-	ko:K19339	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind,Fer4_5
k59_196089_1	525897.Dbac_1216	1.22e-50	168.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42PNX@68525|delta/epsilon subdivisions,2WK8F@28221|Deltaproteobacteria,2M8X5@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cysteine-rich domain	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
k59_1664991_1	349521.HCH_00106	5.67e-80	242.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,1RW0G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Coenzyme F420-reducing hydrogenase, gamma subunit	hoxY	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
k59_666449_1	439235.Dalk_5090	6.09e-89	288.0	COG1018@1|root,COG1148@1|root,COG1018@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
k59_548443_1	243233.MCA1437	1.93e-23	99.0	COG1922@1|root,COG2148@1|root,COG1922@2|Bacteria,COG2148@2|Bacteria,1N1HD@1224|Proteobacteria,1RP6P@1236|Gammaproteobacteria,1XFRP@135618|Methylococcales	135618|Methylococcales	M	Belongs to the glycosyltransferase 26 family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
k59_842292_1	1123256.KB907934_gene2436	7.01e-128	383.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1X45G@135614|Xanthomonadales	135614|Xanthomonadales	E	Acetolactate synthase	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_32670_1	583355.Caka_2358	7.05e-36	135.0	COG3137@1|root,COG3137@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
k59_1133440_1	1255043.TVNIR_0100	4.56e-60	199.0	COG1232@1|root,COG1232@2|Bacteria,1R0KQ@1224|Proteobacteria,1S093@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_1493371_1	1121948.AUAC01000003_gene2507	9.07e-56	196.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,43WFJ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs	iorB	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_909580_1	935848.JAEN01000025_gene183	1.89e-28	113.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2TS98@28211|Alphaproteobacteria,2PUFP@265|Paracoccus	28211|Alphaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
k59_909580_2	1488328.JMCL01000018_gene542	2.71e-32	118.0	COG0500@1|root,COG0500@2|Bacteria,1RAE4@1224|Proteobacteria,1S0RC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family	tpm	GO:0003674,GO:0003824,GO:0008119,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008757,GO:0010035,GO:0010038,GO:0016740,GO:0016741,GO:0032259,GO:0042221,GO:0046690,GO:0050896	2.1.1.67	ko:K00569	ko00983,map00983	-	R08236,R08239,R08246	RC00003,RC00980,RC02277	ko00000,ko00001,ko01000	-	-	-	TPMT
k59_548452_1	1177928.TH2_04418	1.91e-13	72.4	COG3346@1|root,COG3346@2|Bacteria,1MWWG@1224|Proteobacteria,2U0N5@28211|Alphaproteobacteria,2JSD9@204441|Rhodospirillales	204441|Rhodospirillales	S	SURF1-like protein	-	-	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
k59_548452_2	1346791.M529_06840	3.49e-21	92.4	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2TT0D@28211|Alphaproteobacteria,2K0KX@204457|Sphingomonadales	204457|Sphingomonadales	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
k59_381288_1	298653.Franean1_6319	1.62e-26	108.0	COG3385@1|root,COG3385@2|Bacteria,2GKQB@201174|Actinobacteria,4EV91@85013|Frankiales	201174|Actinobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
k59_138215_1	1123377.AUIV01000007_gene1241	2.52e-65	224.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X41A@135614|Xanthomonadales	135614|Xanthomonadales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1015219_1	1304865.JAGF01000001_gene2868	1.48e-130	388.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4F0TS@85016|Cellulomonadaceae	201174|Actinobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_666466_1	1131553.JIBI01000001_gene1411	1.23e-111	352.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,2VJ4I@28216|Betaproteobacteria,373W6@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Transmembrane secretion effector	aas	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	Acyltransferase,MFS_1
k59_266430_1	585543.HMPREF0969_02397	3.19e-96	302.0	COG3533@1|root,COG3533@2|Bacteria,4NFW3@976|Bacteroidetes,2FM1I@200643|Bacteroidia,4AKRG@815|Bacteroidaceae	976|Bacteroidetes	S	protein conserved in bacteria	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	F5_F8_type_C,Glyco_hydro_127
k59_32706_1	690850.Desaf_0305	2.56e-61	201.0	COG0176@1|root,COG0176@2|Bacteria,1N9G3@1224|Proteobacteria,42MCK@68525|delta/epsilon subdivisions,2WXRI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
k59_381304_1	1144319.PMI16_05014	2.7e-219	617.0	COG1788@1|root,COG1788@2|Bacteria,1R1R7@1224|Proteobacteria,2WI4N@28216|Betaproteobacteria,4727J@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	malonate decarboxylase, alpha subunit	mdcA	-	2.3.1.187	ko:K13929	-	-	R08944	RC00012,RC00014	ko00000,ko01000,ko02000	3.B.1.1.4	-	-	Mal_decarbox_Al
k59_1370413_2	670307.HYPDE_37328	2.61e-08	60.5	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2TRWK@28211|Alphaproteobacteria,3N8AY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Acts as a magnesium transporter	mgtE	GO:0000287,GO:0003674,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015693,GO:0030001,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0051179,GO:0051234,GO:0070838,GO:0072511	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_724934_1	187272.Mlg_0682	4.09e-29	125.0	COG2199@1|root,COG2200@1|root,COG2204@1|root,COG2200@2|Bacteria,COG2204@2|Bacteria,COG3706@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1WWNV@135613|Chromatiales	135613|Chromatiales	T	PFAM EAL domain	-	-	-	ko:K21025	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg
k59_968601_1	882083.SacmaDRAFT_1933	2.46e-103	322.0	COG0247@1|root,COG0247@2|Bacteria,2GJ7M@201174|Actinobacteria,4DYWI@85010|Pseudonocardiales	201174|Actinobacteria	C	Fe-S oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_1604477_1	666681.M301_1476	4.84e-58	189.0	COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,2VIZ9@28216|Betaproteobacteria,2KKWX@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Protein of unknown function (DUF1365)	-	-	-	ko:K09701	-	-	-	-	ko00000	-	-	-	DUF1365
k59_1195118_1	1380354.JIAN01000006_gene694	7.51e-75	237.0	COG0454@1|root,COG0456@2|Bacteria,2I0BQ@201174|Actinobacteria,4F17M@85016|Cellulomonadaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1604480_1	367299.JOEE01000003_gene2900	3.8e-75	230.0	COG2884@1|root,COG2884@2|Bacteria,2GJE1@201174|Actinobacteria,4FF75@85021|Intrasporangiaceae	201174|Actinobacteria	D	Cell division	ftsE	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_314021_1	1504981.KO116_1787	1.11e-47	163.0	COG0457@1|root,COG0457@2|Bacteria,1QVJZ@1224|Proteobacteria,1T372@1236|Gammaproteobacteria,1XRUR@135619|Oceanospirillales	135619|Oceanospirillales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
k59_32735_1	744979.R2A130_1799	1.54e-32	123.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2TRAA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1859052_1	1432050.IE4771_CH02322	3.93e-20	89.7	COG1082@1|root,COG1082@2|Bacteria,1PJT1@1224|Proteobacteria,2VE23@28211|Alphaproteobacteria,4BCWJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
k59_1200641_1	512565.AMIS_30710	4.45e-68	216.0	COG2267@1|root,COG2267@2|Bacteria,2IMQQ@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1138428_1	269482.Bcep1808_5371	7.55e-05	45.4	COG1488@1|root,COG1488@2|Bacteria,1MWA2@1224|Proteobacteria,2VN4E@28216|Betaproteobacteria,1K10A@119060|Burkholderiaceae	28216|Betaproteobacteria	H	nicotinate	-	-	2.4.2.12	ko:K03462	ko00760,ko01100,ko04621,map00760,map01100,map04621	-	R01271	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
k59_1138428_2	161528.ED21_19967	2.39e-71	226.0	COG1051@1|root,COG1056@1|root,COG1051@2|Bacteria,COG1056@2|Bacteria,1MWNH@1224|Proteobacteria,2U4V0@28211|Alphaproteobacteria,2K3ZZ@204457|Sphingomonadales	204457|Sphingomonadales	FH	Cytidylyltransferase-like	-	-	2.7.7.1	ko:K13522	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like,NUDIX
k59_274081_1	717785.HYPMC_0054	4.77e-63	205.0	COG3637@1|root,COG3637@2|Bacteria,1RBBG@1224|Proteobacteria,2U5ED@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Lipid A oxidase	lpxQ	-	-	ko:K12980	-	-	-	-	ko00000,ko01005	-	-	-	OMP_b-brl
k59_202204_1	1267005.KB911263_gene1379	7.61e-79	255.0	COG5426@1|root,COG5426@2|Bacteria,1MVWA@1224|Proteobacteria,2TQNQ@28211|Alphaproteobacteria,3N89S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	membrane	MA20_44660	-	-	-	-	-	-	-	-	-	-	-	GATase1_like
k59_612712_1	292415.Tbd_0053	1.37e-38	141.0	2EFRD@1|root,339HE@2|Bacteria,1NDZX@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1609661_1	555779.Dthio_PD3802	5.7e-45	169.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_1330820_2	237609.PSAKL28_22630	1.66e-193	539.0	COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,1RPKM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
k59_1330820_3	1207075.PputUW4_02133	1.11e-133	385.0	COG0454@1|root,COG0454@2|Bacteria,1MVVG@1224|Proteobacteria,1RQ5J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1091112_1	335543.Sfum_0006	1.16e-53	179.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,42M0M@68525|delta/epsilon subdivisions,2WJ4Y@28221|Deltaproteobacteria,2MQCV@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	kpsF	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
k59_1435737_1	670307.HYPDE_26043	9.37e-12	64.3	2ED3M@1|root,3370H@2|Bacteria,1NB6I@1224|Proteobacteria,2UE8V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1860252_1	472759.Nhal_3802	1.43e-107	335.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1WXCY@135613|Chromatiales	135613|Chromatiales	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_320254_1	269799.Gmet_2580	4.44e-134	425.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA1	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_392288_1	945713.IALB_0134	4.18e-67	220.0	COG0572@1|root,COG0572@2|Bacteria	2|Bacteria	F	uridine kinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
k59_979770_1	743720.Psefu_0419	1.34e-54	190.0	COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,1RSQ1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Zn-dependent protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_1610333_1	765912.Thimo_1923	8.75e-43	141.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria,1WYKM@135613|Chromatiales	135613|Chromatiales	S	RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_144331_1	565045.NOR51B_2243	3.82e-25	109.0	COG1463@1|root,COG1463@2|Bacteria,1Q6ZU@1224|Proteobacteria,1S6SW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	MlaD protein	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_144331_2	243233.MCA0364	1.22e-27	107.0	COG3009@1|root,COG3009@2|Bacteria,1N8BW@1224|Proteobacteria,1SHZZ@1236|Gammaproteobacteria,1XF9Y@135618|Methylococcales	135618|Methylococcales	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K09857	-	-	-	-	ko00000	-	-	-	ABC_trans_aux
k59_1138969_1	36080.S2JTL2	7.92e-12	67.8	29MFU@1|root,2RURV@2759|Eukaryota,38WI9@33154|Opisthokonta,3Q0NB@4751|Fungi,1GWT3@112252|Fungi incertae sedis	4751|Fungi	S	Uncharacterized conserved protein (DUF2183)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2183
k59_979774_1	1121935.AQXX01000132_gene2616	1.54e-48	187.0	COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1XHS8@135619|Oceanospirillales	135619|Oceanospirillales	DM	COG3264 Small-conductance mechanosensitive channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM,MscS_porin
k59_1500434_1	391626.OAN307_c17510	4.26e-158	447.0	COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_1610336_1	96561.Dole_0628	2.36e-16	73.9	COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,42VWC@68525|delta/epsilon subdivisions,2WS5S@28221|Deltaproteobacteria,2MKV4@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
k59_848508_1	999541.bgla_1g06860	3.42e-36	134.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2VHEP@28216|Betaproteobacteria,1K1TT@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
k59_202887_1	1386089.N865_10160	2.94e-176	501.0	COG0446@1|root,COG0446@2|Bacteria,2GRTN@201174|Actinobacteria,4FFV5@85021|Intrasporangiaceae	201174|Actinobacteria	S	Oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DsrC,Pyr_redox_2
k59_202887_2	367299.JOEE01000004_gene1033	1.43e-22	95.9	COG0033@1|root,COG0033@2|Bacteria,2H1PI@201174|Actinobacteria,4FFBE@85021|Intrasporangiaceae	201174|Actinobacteria	G	Phosphoglucomutase	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1552190_1	999611.KI421505_gene4132	4.7e-45	160.0	COG1593@1|root,COG1593@2|Bacteria,1QNVU@1224|Proteobacteria,2U0UE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system large permease component	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM
k59_320264_1	270374.MELB17_14753	8.34e-150	473.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,1RMW9@1236|Gammaproteobacteria,465S2@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Cellobiose phosphorylase	ndvB	-	2.4.1.20,2.4.1.280	ko:K00702,ko:K13688,ko:K18675	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00952,R09942	RC00049	ko00000,ko00001,ko01000,ko01003	-	GH94,GT36,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
k59_392305_1	1150469.RSPPHO_00678	2.36e-52	184.0	COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,2TU5K@28211|Alphaproteobacteria,2JQRQ@204441|Rhodospirillales	204441|Rhodospirillales	J	Specifically methylates the adenine in position 2030 of 23S rRNA	rlmJ	-	2.1.1.266	ko:K07115	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RsmJ
k59_1436381_1	316057.RPD_2105	3.79e-48	163.0	COG1125@1|root,COG1125@2|Bacteria,1QTUC@1224|Proteobacteria,2TTMA@28211|Alphaproteobacteria,3JSPY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ABC transporter	yehX	GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0031460,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0072337	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran,CBS
k59_613352_1	706587.Desti_4232	4.37e-30	116.0	COG4177@1|root,COG4177@2|Bacteria,1N5I8@1224|Proteobacteria,42UTS@68525|delta/epsilon subdivisions,2WQM7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_613352_2	1232410.KI421421_gene3447	2.87e-24	98.6	COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,42RIK@68525|delta/epsilon subdivisions,2WNDV@28221|Deltaproteobacteria,43TWN@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_275052_1	1121271.AUCM01000005_gene629	1.14e-12	71.6	COG1011@1|root,COG1011@2|Bacteria,1RHAB@1224|Proteobacteria,2U7PV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	hydrolase (HAD superfamily)	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
k59_202893_1	1123393.KB891332_gene2729	4.51e-48	167.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VISA@28216|Betaproteobacteria,1KS4R@119069|Hydrogenophilales	119069|Hydrogenophilales	C	4Fe-4S dicluster domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7
k59_1376253_1	1123399.AQVE01000012_gene2903	3.57e-40	147.0	COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,45ZSR@72273|Thiotrichales	72273|Thiotrichales	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase
k59_1332004_1	481448.Minf_1693	1.3e-90	281.0	COG0154@1|root,COG0154@2|Bacteria,46SCM@74201|Verrucomicrobia,37FYA@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_554698_1	338969.Rfer_2623	2.08e-63	202.0	COG0614@1|root,COG0614@2|Bacteria,1PKNF@1224|Proteobacteria,2VMK5@28216|Betaproteobacteria,4AA7N@80864|Comamonadaceae	28216|Betaproteobacteria	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
k59_554698_2	391165.GbCGDNIH1_1855	1.36e-53	186.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TT6V@28211|Alphaproteobacteria,2JPWF@204441|Rhodospirillales	204441|Rhodospirillales	P	Voltage gated chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
k59_1138986_1	105559.Nwat_0676	4.2e-17	79.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria,1WY7U@135613|Chromatiales	135613|Chromatiales	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
k59_1138986_2	768671.ThimaDRAFT_4262	2.88e-77	238.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1WXAU@135613|Chromatiales	135613|Chromatiales	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_1728759_1	1236541.BALL01000060_gene4597	1.29e-54	192.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RYVY@1236|Gammaproteobacteria,2Q9T1@267890|Shewanellaceae	1236|Gammaproteobacteria	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	-	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_320293_1	1232410.KI421425_gene1552	2.4e-106	346.0	COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
k59_920743_1	663610.JQKO01000008_gene199	4.6e-81	269.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR56@28211|Alphaproteobacteria,3N9V6@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	haloacid dehalogenase-like hydrolase	cadA	-	-	-	-	-	-	-	-	-	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
k59_1091908_1	1552758.NC00_02440	2.63e-32	130.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,1RQ06@1236|Gammaproteobacteria,1X3QM@135614|Xanthomonadales	135614|Xanthomonadales	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
k59_275105_1	519989.ECTPHS_05831	1.04e-63	199.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,1WY89@135613|Chromatiales	135613|Chromatiales	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	-	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
k59_920748_2	670307.HYPDE_31248	3.12e-55	181.0	COG0373@1|root,COG0373@2|Bacteria,1MXX5@1224|Proteobacteria,2U1CR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal	-	-	-	ko:K10714	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R08059	RC00202	ko00000,ko00001,ko01000	-	-	-	Mpt_N
k59_1860347_1	1056820.KB900681_gene2859	3.36e-81	252.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,1RMHK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG3385 FOG Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_437382_1	10224.XP_006820442.1	8.33e-21	97.8	COG2801@1|root,2S2R5@2759|Eukaryota,39MHM@33154|Opisthokonta,3CP4C@33208|Metazoa,3E58K@33213|Bilateria	33208|Metazoa	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	Dam,RVT_1,RVT_3
k59_1332072_1	107636.JQNK01000009_gene3513	5.43e-98	300.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,370BU@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_554726_1	367299.JOEE01000004_gene973	1.62e-116	365.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4FE2X@85021|Intrasporangiaceae	201174|Actinobacteria	C	part of alternative pathway from alpha-ketoglutarate to succinate	kgd	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1248c	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_672643_1	1276756.AUEX01000049_gene2209	4.38e-39	139.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2VI1H@28216|Betaproteobacteria,4ABHU@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_144385_1	402881.Plav_1459	5.8e-82	248.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,2TQJB@28211|Alphaproteobacteria,1JNPK@119043|Rhodobiaceae	28211|Alphaproteobacteria	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
k59_731230_1	187272.Mlg_0001	5.25e-102	309.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1WW6C@135613|Chromatiales	135613|Chromatiales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_1332090_2	396588.Tgr7_2137	3.49e-07	52.8	COG1714@1|root,COG1714@2|Bacteria	2|Bacteria	S	RDD family	VP2641	-	-	-	-	-	-	-	-	-	-	-	RDD
k59_848564_1	74547.PMT_0230	3.43e-42	154.0	COG0769@1|root,COG0769@2|Bacteria,1G0HH@1117|Cyanobacteria,1MM0Z@1212|Prochloraceae	1117|Cyanobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_672655_1	425104.Ssed_1377	1.3e-74	234.0	COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,1S3TH@1236|Gammaproteobacteria,2QAZF@267890|Shewanellaceae	1236|Gammaproteobacteria	I	PFAM Alpha beta hydrolase fold-3 domain protein	aes	-	3.1.1.83	ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	-	R03751,R06390,R06391,R06392,R06393	RC00713,RC00983,RC01505	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3
k59_41973_1	1123511.KB905839_gene413	6.9e-33	125.0	COG3494@1|root,COG3494@2|Bacteria,1U1G6@1239|Firmicutes,4H2CZ@909932|Negativicutes	909932|Negativicutes	S	Psort location Cytoplasmic, score 8.96	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
k59_41973_2	880073.Calab_1198	1.88e-27	110.0	COG0763@1|root,COG0763@2|Bacteria,2NP10@2323|unclassified Bacteria	2|Bacteria	I	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
k59_98958_1	945713.IALB_2357	3.71e-12	65.9	COG0705@1|root,COG0705@2|Bacteria	2|Bacteria	S	proteolysis	SEN0012	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
k59_98958_2	387092.NIS_0928	3.08e-80	247.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,42P56@68525|delta/epsilon subdivisions,2YNV5@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_848569_1	472759.Nhal_0572	2.7e-160	461.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1WWAV@135613|Chromatiales	135613|Chromatiales	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_848569_2	572477.Alvin_2861	1.42e-19	87.8	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1WWAT@135613|Chromatiales	135613|Chromatiales	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_275153_1	96561.Dole_0733	1.36e-63	204.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,42MIX@68525|delta/epsilon subdivisions,2WJ5K@28221|Deltaproteobacteria,2MI89@213118|Desulfobacterales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_275153_2	96561.Dole_0734	3.2e-48	159.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,42SBD@68525|delta/epsilon subdivisions,2WP9P@28221|Deltaproteobacteria,2MKCX@213118|Desulfobacterales	28221|Deltaproteobacteria	J	PFAM ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
k59_848574_1	257310.BB0876	2.41e-86	267.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,2VJ7A@28216|Betaproteobacteria,3T1BK@506|Alcaligenaceae	28216|Betaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	wbpO	-	-	ko:K02474	ko00520,map00520	-	R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_613422_1	935567.JAES01000005_gene535	2.39e-33	132.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1X3A5@135614|Xanthomonadales	135614|Xanthomonadales	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
k59_1091952_1	1254432.SCE1572_34780	2.59e-05	47.4	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2WNXT@28221|Deltaproteobacteria,2YV4W@29|Myxococcales	28221|Deltaproteobacteria	EGP	of the major facilitator superfamily	agmP	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
k59_1500534_1	631362.Thi970DRAFT_02288	6.71e-100	309.0	COG4146@1|root,COG4146@2|Bacteria,1MXWV@1224|Proteobacteria,1RR4S@1236|Gammaproteobacteria,1X0HX@135613|Chromatiales	135613|Chromatiales	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_1671359_1	519989.ECTPHS_08968	6.39e-182	555.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1WX9H@135613|Chromatiales	135613|Chromatiales	C	pyruvate flavodoxin ferredoxin oxidoreductase	-	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1860414_1	1123355.JHYO01000007_gene390	1.6e-28	107.0	COG2905@1|root,COG2905@2|Bacteria,1MZGY@1224|Proteobacteria,2UUUA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_1860414_2	2340.JV46_27560	3.1e-41	139.0	COG0347@1|root,COG0347@2|Bacteria,1RI28@1224|Proteobacteria,1S62Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the P(II) protein family	VV0993	-	-	-	-	-	-	-	-	-	-	-	-
k59_1860414_3	1121451.DESAM_21453	1.9e-103	309.0	arCOG03638@1|root,2Z8W3@2|Bacteria,1N2PH@1224|Proteobacteria,42Q9C@68525|delta/epsilon subdivisions,2WJI4@28221|Deltaproteobacteria,2MB1X@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1538)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1538
k59_1860414_4	318167.Sfri_2271	1.31e-52	173.0	arCOG03638@1|root,2Z7NN@2|Bacteria,1R3Y6@1224|Proteobacteria,1RTWY@1236|Gammaproteobacteria,2QB9B@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1538)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1538
k59_672681_1	313606.M23134_07719	5.02e-30	122.0	COG5000@1|root,COG5000@2|Bacteria,4NEWF@976|Bacteroidetes,47JZG@768503|Cytophagia	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_275162_1	1116472.MGMO_159c00020	2.92e-83	256.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,1RQ57@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the class I fructose-bisphosphate aldolase family	alf1	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
k59_275162_2	29495.EA26_04895	4.32e-43	145.0	COG2905@1|root,COG2905@2|Bacteria,1MZGY@1224|Proteobacteria,1S86K@1236|Gammaproteobacteria,1XXFK@135623|Vibrionales	135623|Vibrionales	T	COG0517 FOG CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_144428_1	935839.JAGJ01000010_gene338	3.31e-106	325.0	COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria,4F3BX@85017|Promicromonosporaceae	201174|Actinobacteria	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_144428_2	446471.Xcel_0960	7.4e-11	63.9	2DME2@1|root,32QVN@2|Bacteria,2HM0F@201174|Actinobacteria,4F5UV@85017|Promicromonosporaceae	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_6
k59_1500544_1	1193181.BN10_930026	3.86e-69	220.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4FF3P@85021|Intrasporangiaceae	201174|Actinobacteria	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1436474_1	713586.KB900536_gene2574	2.12e-70	231.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,1RP55@1236|Gammaproteobacteria,1WWS0@135613|Chromatiales	135613|Chromatiales	P	inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_1139047_1	1380390.JIAT01000009_gene792	5.65e-33	119.0	COG3631@1|root,COG3631@2|Bacteria,2HR3T@201174|Actinobacteria,4CSZ6@84995|Rubrobacteria	84995|Rubrobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
k59_1082467_1	1304865.JAGF01000001_gene1450	2.35e-17	83.6	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,2GIT4@201174|Actinobacteria,4F1UH@85016|Cellulomonadaceae	201174|Actinobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	mrpA/mrpB	-	-	ko:K05565,ko:K14086	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
k59_1082467_2	471853.Bcav_3817	3.15e-66	207.0	COG1006@1|root,COG1006@2|Bacteria,2ISBC@201174|Actinobacteria	201174|Actinobacteria	P	Multisubunit Na H antiporter MnhC subunit	mrpC	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
k59_1428269_1	43759.JNWK01000003_gene1315	2.88e-63	215.0	COG0210@1|root,COG0210@2|Bacteria,2GKRW@201174|Actinobacteria	201174|Actinobacteria	L	DNA helicase	uvrD2	GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HRDC,UvrD-helicase,UvrD_C
k59_546648_1	1121405.dsmv_0352	9.56e-68	226.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2MHZN@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
k59_1846386_2	2340.JV46_26710	3.86e-42	144.0	2AB8D@1|root,310NU@2|Bacteria,1RFGC@1224|Proteobacteria,1S5A2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_29635_1	1382304.JNIL01000001_gene1212	4.92e-23	104.0	COG0165@1|root,COG0165@2|Bacteria,1U4V0@1239|Firmicutes,4HE7Q@91061|Bacilli,27ARF@186823|Alicyclobacillaceae	91061|Bacilli	E	Argininosuccinate lyase C-terminal	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_1256623_1	744980.TRICHSKD4_5980	1.67e-107	316.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_1779131_1	765913.ThidrDRAFT_1077	3.98e-92	282.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1WWUV@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_965981_1	465515.Mlut_08850	2.44e-14	78.2	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,1W8BA@1268|Micrococcaceae	201174|Actinobacteria	E	aminotransferase class I and II	dapC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.6.1.1,2.6.1.17,2.6.1.2,2.6.1.66	ko:K00812,ko:K14260,ko:K14267	ko00220,ko00250,ko00270,ko00290,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01130,map01210,map01230	M00016	R00258,R00355,R00694,R00734,R00896,R01215,R02433,R02619,R04475,R05052	RC00006,RC00008,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iNJ661.Rv0858c	Aminotran_1_2
k59_840513_1	1304865.JAGF01000001_gene444	1.53e-80	245.0	2BDZ4@1|root,327PI@2|Bacteria,2IN10@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_840513_2	1304865.JAGF01000001_gene443	5.77e-150	443.0	COG0464@1|root,COG0464@2|Bacteria,2GJWA@201174|Actinobacteria	201174|Actinobacteria	O	AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_1193253_1	519989.ECTPHS_02821	8.43e-149	436.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1WXVV@135613|Chromatiales	135613|Chromatiales	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_1544547_2	28229.ND2E_1534	2.04e-54	181.0	COG1226@1|root,32Y28@2|Bacteria,1NEAT@1224|Proteobacteria,1S588@1236|Gammaproteobacteria,2Q6SK@267889|Colwelliaceae	1236|Gammaproteobacteria	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
k59_1544547_3	550540.Fbal_2868	1.66e-13	71.2	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1013685_2	1303518.CCALI_00850	9.87e-74	233.0	COG0150@1|root,COG0150@2|Bacteria	2|Bacteria	F	phosphoribosylformylglycinamidine cyclo-ligase activity	purM	GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.1,6.3.4.13	ko:K01933,ko:K11788	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208	RC00090,RC00166,RC01100	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1844,iECSF_1327.ECSF_2340	AIRS,AIRS_C
k59_1318251_1	1049564.TevJSym_ap00750	1.7e-50	168.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,1J6GX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Thioredoxin	ybbN	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0061077	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_965994_1	926692.AZYG01000040_gene1536	3.41e-27	112.0	COG1560@1|root,COG1560@2|Bacteria,1TT7A@1239|Firmicutes,24HMK@186801|Clostridia,3WANH@53433|Halanaerobiales	186801|Clostridia	M	PFAM Bacterial lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_85215_1	1120705.FG95_00338	7.36e-88	287.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,2K2DM@204457|Sphingomonadales	204457|Sphingomonadales	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
k59_1544551_2	472759.Nhal_2676	1.23e-12	68.2	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1WWPM@135613|Chromatiales	135613|Chromatiales	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
k59_1663191_1	446466.Cfla_1355	5e-37	132.0	COG0824@1|root,COG0824@2|Bacteria,2IFAK@201174|Actinobacteria,4F16M@85016|Cellulomonadaceae	201174|Actinobacteria	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
k59_195091_1	1388763.O165_011810	1.61e-47	164.0	COG0300@1|root,COG0300@2|Bacteria,1RAFB@1224|Proteobacteria,1S2HE@1236|Gammaproteobacteria,1YUZC@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_195091_2	76114.ebA6241	2.03e-17	79.0	COG0819@1|root,COG0819@2|Bacteria,1MVA0@1224|Proteobacteria,2WGSW@28216|Betaproteobacteria,2KVR3@206389|Rhodocyclales	206389|Rhodocyclales	K	Iron-containing redox enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Haem_oxygenas_2
k59_29668_1	1500304.JQKY01000021_gene2043	9.92e-65	221.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,4B8TD@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	efflux pump	acrF	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_85219_1	1123393.KB891316_gene1901	1.2e-34	128.0	COG1108@1|root,COG1108@2|Bacteria,1PM37@1224|Proteobacteria,2VM6C@28216|Betaproteobacteria,1KSR9@119069|Hydrogenophilales	119069|Hydrogenophilales	P	ABC 3 transport family	-	-	-	-	-	-	-	-	-	-	-	-	ABC-3
k59_1318255_1	1194972.MVAC_10442	3.57e-102	319.0	COG1226@1|root,COG1226@2|Bacteria,2HX5T@201174|Actinobacteria,237N6@1762|Mycobacteriaceae	201174|Actinobacteria	P	TrkA-N domain	-	-	-	-	-	-	-	-	-	-	-	-	TrkA_N
k59_1256651_1	164757.Mjls_1710	7.45e-134	389.0	COG2801@1|root,COG2801@2|Bacteria,2GJ3V@201174|Actinobacteria,237S9@1762|Mycobacteriaceae	201174|Actinobacteria	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,LZ_Tnp_IS481,rve
k59_907093_1	631362.Thi970DRAFT_03602	3.6e-108	322.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1WW6R@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_85228_1	438753.AZC_3975	1.83e-15	80.9	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TQRE@28211|Alphaproteobacteria,3EYV5@335928|Xanthobacteraceae	28211|Alphaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	envZ	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_29679_1	1454010.JEOE01000020_gene2618	8e-36	130.0	COG1611@1|root,COG1611@2|Bacteria,2GKJH@201174|Actinobacteria,4F0Z3@85016|Cellulomonadaceae	201174|Actinobacteria	S	Belongs to the LOG family	fmt2	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_29679_2	1454010.JEOE01000020_gene2616	1.38e-18	86.3	COG5542@1|root,COG5542@2|Bacteria,2GJQF@201174|Actinobacteria,4F0YR@85016|Cellulomonadaceae	201174|Actinobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2,PMT_2
k59_723186_2	686340.Metal_1405	4.7e-117	344.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,1XE38@135618|Methylococcales	135618|Methylococcales	T	PFAM PhoH-like protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_29680_1	1267533.KB906734_gene4066	0.000921	48.9	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria	57723|Acidobacteria	KU	WD40 domain protein beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
k59_1544563_1	1121124.JNIX01000009_gene2790	2.31e-79	250.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2TQMA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	oxidase subunit	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_263550_1	1151119.KB895489_gene650	1.82e-143	423.0	COG0365@1|root,COG0365@2|Bacteria,2GNE8@201174|Actinobacteria	201174|Actinobacteria	I	synthetase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_263550_2	272134.KB731324_gene5875	1.69e-34	127.0	COG1071@1|root,COG1071@2|Bacteria,1G00Z@1117|Cyanobacteria,1H7WM@1150|Oscillatoriales	2|Bacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00162,ko:K11381,ko:K21416	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
k59_840528_2	590998.Celf_1495	1.4e-158	463.0	COG0004@1|root,COG0004@2|Bacteria,2GIZK@201174|Actinobacteria,4F1S2@85016|Cellulomonadaceae	201174|Actinobacteria	P	Ammonium Transporter Family	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_664764_1	1249627.D779_1899	2.56e-58	204.0	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,1S08E@1236|Gammaproteobacteria,1WXTS@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_85241_2	391615.ABSJ01000032_gene724	5.24e-59	196.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1J4RF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the MurCDEF family	murC	GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iECP_1309.ECP_0093	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_966032_1	446466.Cfla_1510	8.76e-128	390.0	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4F0Z9@85016|Cellulomonadaceae	201174|Actinobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_1602791_1	1049564.TevJSym_aa00630	1.97e-46	159.0	COG0642@1|root,COG0642@2|Bacteria,1PA1G@1224|Proteobacteria,1T1HX@1236|Gammaproteobacteria,1JC34@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_312149_2	400682.PAC_15711180	4.09e-58	188.0	COG0277@1|root,KOG1231@2759|Eukaryota,3AP0I@33154|Opisthokonta	33154|Opisthokonta	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
k59_723202_1	1121403.AUCV01000026_gene2337	8.66e-05	45.1	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIB8@213118|Desulfobacterales	28221|Deltaproteobacteria	T	response regulator receiver	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_723202_2	1449126.JQKL01000043_gene1887	9.61e-10	59.7	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,268PT@186813|unclassified Clostridiales	186801|Clostridia	K	ECF sigma factor	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1428317_2	760192.Halhy_3650	3.04e-21	94.0	COG0318@1|root,COG3320@1|root,COG0318@2|Bacteria,COG3320@2|Bacteria,4NHYN@976|Bacteroidetes	976|Bacteroidetes	IQ	AMP-dependent synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,PP-binding
k59_1720623_1	314285.KT71_08620	3.63e-198	558.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria,1J9WI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase, Mutator family	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_1544577_1	883078.HMPREF9695_04566	6.88e-20	86.7	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2TSUR@28211|Alphaproteobacteria,3JTTD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
k59_1544577_2	1500893.JQNB01000001_gene1920	4.1e-58	193.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,1RPA1@1236|Gammaproteobacteria,1X4KK@135614|Xanthomonadales	135614|Xanthomonadales	C	Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain	-	-	-	-	-	-	-	-	-	-	-	-	FMN_dh
k59_85252_1	998674.ATTE01000001_gene417	6.45e-93	290.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,4623I@72273|Thiotrichales	72273|Thiotrichales	O	Cytochrome c-type biogenesis protein CcmF C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	CcmF_C,Cytochrom_C_asm
k59_605325_1	765912.Thimo_2434	7.5e-46	164.0	COG1018@1|root,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,1T2FP@1236|Gammaproteobacteria,1WWXW@135613|Chromatiales	135613|Chromatiales	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2
k59_841108_1	1120792.JAFV01000001_gene1076	4.79e-27	105.0	COG2220@1|root,COG2220@2|Bacteria,1MUY6@1224|Proteobacteria,2TV26@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
k59_841108_2	670307.HYPDE_35163	9.24e-41	136.0	COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2UBSZ@28211|Alphaproteobacteria,3N76V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
k59_547235_1	1121405.dsmv_0229	2.04e-80	253.0	COG0019@1|root,COG0019@2|Bacteria,1R96G@1224|Proteobacteria,42P87@68525|delta/epsilon subdivisions,2WJD9@28221|Deltaproteobacteria,2MJ7I@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM Orn DAP Arg decarboxylase 2	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_723740_1	323261.Noc_2867	9.13e-192	555.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1WWDS@135613|Chromatiales	135613|Chromatiales	M	Catalyzes cross-linking of the peptidoglycan cell wall at the division septum	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
k59_264476_1	56780.SYN_02761	1.37e-65	222.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,2MQYI@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Carbohydrate phosphorylase	glgP	-	2.4.1.1,2.4.1.11	ko:K00688,ko:K16153	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R00292,R02111	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT3,GT35	-	DUF3417,Phosphorylase
k59_86086_1	999541.bgla_1g31070	9.19e-55	173.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2VSEZ@28216|Betaproteobacteria,1K7M9@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the P(II) protein family	glnB	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
k59_1428878_1	639282.DEFDS_2134	0.000479	47.8	COG1391@1|root,COG1391@2|Bacteria,2GEZ7@200930|Deferribacteres	200930|Deferribacteres	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	-	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_1193845_1	931627.MycrhDRAFT_1834	3.43e-15	80.9	COG0596@1|root,COG0596@2|Bacteria,2ICU6@201174|Actinobacteria,23640@1762|Mycobacteriaceae	201174|Actinobacteria	S	TAP-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
k59_1847287_1	765913.ThidrDRAFT_0536	2.44e-34	125.0	COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,1S69P@1236|Gammaproteobacteria,1WX67@135613|Chromatiales	135613|Chromatiales	K	cyclic nucleotide-binding	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_1257327_2	1283300.ATXB01000002_gene2887	2.58e-29	113.0	COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria,1RZUI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	cytochrome C family protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Paired_CXXCH_1
k59_547239_1	472759.Nhal_3387	2.93e-78	246.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RPMN@1236|Gammaproteobacteria,1WVVR@135613|Chromatiales	135613|Chromatiales	M	PFAM glycosyl transferase family 9	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
k59_841119_1	649743.HMPREF0972_00139	1.55e-79	252.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4D3I6@85005|Actinomycetales	201174|Actinobacteria	U	Helicase secretion neighborhood ATPase	cpaF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
k59_723750_1	1255043.TVNIR_0253	2.27e-55	184.0	COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,1WWM6@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator	-	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
k59_1779763_1	1313265.JNIE01000004_gene576	3.01e-06	50.8	COG0526@1|root,COG0526@2|Bacteria,2G4E6@200783|Aquificae	200783|Aquificae	CO	Thioredoxin domain-containing protein	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_1369286_2	593907.Celgi_1368	7.37e-44	153.0	COG1579@1|root,COG1579@2|Bacteria,2GP84@201174|Actinobacteria,4F15G@85016|Cellulomonadaceae	201174|Actinobacteria	S	C4-type zinc ribbon domain	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
k59_1779764_1	590998.Celf_2602	2.44e-09	65.9	COG0739@1|root,COG3883@1|root,COG0739@2|Bacteria,COG3883@2|Bacteria,2I2K6@201174|Actinobacteria,4F1TM@85016|Cellulomonadaceae	201174|Actinobacteria	M	Peptidase family M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
k59_1428890_1	367299.JOEE01000004_gene1376	2.09e-124	374.0	COG1770@1|root,COG1770@2|Bacteria,2GNA9@201174|Actinobacteria,4FF4B@85021|Intrasporangiaceae	201174|Actinobacteria	E	oligopeptidase that cleaves peptide bonds following arginine and lysine residues	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_86110_1	187272.Mlg_0413	3.86e-110	333.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1WWPA@135613|Chromatiales	135613|Chromatiales	S	modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_1545180_2	765912.Thimo_1320	1.1e-05	47.4	2BTT6@1|root,32P0R@2|Bacteria,1RKJP@1224|Proteobacteria,1S6ZB@1236|Gammaproteobacteria,1WYHA@135613|Chromatiales	135613|Chromatiales	S	Sulphur globule protein	-	-	-	-	-	-	-	-	-	-	-	-	SGP
k59_264506_1	1124983.PFLCHA0_c17040	3.43e-78	244.0	COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,1RMZ2@1236|Gammaproteobacteria,1YMD4@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	D	Belongs to the ParA family	fleN	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	ParA
k59_312775_1	232721.Ajs_0418	1.95e-130	380.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,4AB13@80864|Comamonadaceae	28216|Betaproteobacteria	NU	PFAM Type II secretion system protein E	pilU	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_312775_2	1122604.JONR01000015_gene103	2.91e-23	99.8	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1X3FB@135614|Xanthomonadales	135614|Xanthomonadales	NU	twitching motility protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
k59_1491983_1	697282.Mettu_3066	2.26e-54	180.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1S2WI@1236|Gammaproteobacteria,1XEYK@135618|Methylococcales	135618|Methylococcales	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_1721244_1	105559.Nwat_1090	8.25e-110	349.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales	135613|Chromatiales	E	Vitamin B12 dependent methionine synthase activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_547256_1	366394.Smed_5626	5.14e-62	198.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,2U1SQ@28211|Alphaproteobacteria,4BAX2@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
k59_723765_1	593907.Celgi_2026	3.75e-82	248.0	COG2813@1|root,COG2813@2|Bacteria,2IFG7@201174|Actinobacteria,4F15C@85016|Cellulomonadaceae	201174|Actinobacteria	J	Methyltransferase small domain	rsmC	-	2.1.1.172	ko:K00564	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	MTS
k59_1491988_2	6412.HelroP181660	0.000112	48.1	COG2605@1|root,KOG4644@2759|Eukaryota,38G1P@33154|Opisthokonta,3BA8K@33208|Metazoa,3CTH8@33213|Bilateria	33208|Metazoa	G	GDP-L-fucose salvage	FUK	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009225,GO:0009226,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0042350,GO:0042352,GO:0043094,GO:0043173,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046368,GO:0046483,GO:0046835,GO:0050201,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.1.52	ko:K05305	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R03161	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Fucokinase,GHMP_kinases_C,GHMP_kinases_N
k59_1663813_1	402881.Plav_2672	2.28e-108	333.0	COG0674@1|root,COG0674@2|Bacteria,1QVAZ@1224|Proteobacteria,2TYHW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	pyruvate-flavodoxin oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1319141_1	1463909.KL585957_gene2958	6.08e-83	267.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria	201174|Actinobacteria	G	hydrolase, family 3	bgl2	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_379672_1	488538.SAR116_2154	2.54e-51	174.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2TRYX@28211|Alphaproteobacteria,4BQAF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_379672_2	504472.Slin_1392	2.43e-18	84.3	COG1960@1|root,COG1960@2|Bacteria,4NH3I@976|Bacteroidetes,47MEG@768503|Cytophagia	976|Bacteroidetes	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_100834_1	866536.Belba_2284	4.72e-26	112.0	COG1680@1|root,COG1680@2|Bacteria,4NGZR@976|Bacteroidetes,47M6K@768503|Cytophagia	976|Bacteroidetes	V	Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1093266_2	314345.SPV1_10019	8.29e-33	127.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_4
k59_849647_1	68194.JNXR01000004_gene4562	0.000805	47.4	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_922785_1	1122212.AULO01000007_gene2615	1.34e-14	71.6	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,1XJCZ@135619|Oceanospirillales	135619|Oceanospirillales	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
k59_922785_2	1442599.JAAN01000031_gene1435	3.54e-72	228.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1X31Z@135614|Xanthomonadales	135614|Xanthomonadales	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_394344_1	1134912.AJTV01000023_gene2878	1.8e-61	206.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria,36Y6U@31993|Methylocystaceae	28211|Alphaproteobacteria	MU	Outer membrane efflux protein	oprN	-	-	ko:K18300,ko:K19593	-	M00641,M00769	-	-	ko00000,ko00002,ko01504,ko02000	1.B.17,2.A.6.2.34	-	-	OEP
k59_1202503_2	1392501.JIAC01000001_gene2139	1.38e-24	104.0	COG0037@1|root,COG0634@1|root,COG0037@2|Bacteria,COG0634@2|Bacteria,1TPXP@1239|Firmicutes,4H3GM@909932|Negativicutes	909932|Negativicutes	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
k59_1787228_1	572477.Alvin_2147	6.18e-65	206.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,1WY6R@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_100860_1	247490.KSU1_C1104	1.91e-43	163.0	COG0823@1|root,COG3291@1|root,COG3828@1|root,COG0823@2|Bacteria,COG3291@2|Bacteria,COG3828@2|Bacteria,2J1GZ@203682|Planctomycetes	203682|Planctomycetes	U	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD
k59_1139978_1	644801.Psest_0975	4.95e-17	78.6	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,1Z1F1@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN746.PP_4715	TIM
k59_1139978_2	765911.Thivi_3910	9.69e-23	94.7	COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,1SD3P@1236|Gammaproteobacteria,1WZFD@135613|Chromatiales	135613|Chromatiales	U	PFAM Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
k59_555907_1	1185766.DL1_16695	4.86e-116	340.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,2XKI8@285107|Thioclava	28211|Alphaproteobacteria	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
k59_438576_1	367299.JOEE01000005_gene3471	5.2e-164	490.0	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,4FEJ7@85021|Intrasporangiaceae	201174|Actinobacteria	EF	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_981856_1	1035308.AQYY01000001_gene2533	5.84e-61	203.0	COG4552@1|root,COG4552@2|Bacteria,1TRPM@1239|Firmicutes,24AP4@186801|Clostridia,262V5@186807|Peptococcaceae	186801|Clostridia	S	Sterol carrier protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
k59_849667_1	870187.Thini_2730	3.08e-21	90.5	arCOG03638@1|root,2Z8W3@2|Bacteria,1N2PH@1224|Proteobacteria,1RMI8@1236|Gammaproteobacteria,461N8@72273|Thiotrichales	72273|Thiotrichales	S	Protein of unknown function (DUF1538)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1538
k59_849667_2	631362.Thi970DRAFT_00795	3.47e-110	325.0	arCOG03638@1|root,2Z7NN@2|Bacteria,1R3Y6@1224|Proteobacteria,1RTWY@1236|Gammaproteobacteria,1X2HW@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1538)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1538
k59_849667_3	1500890.JQNL01000001_gene3064	1.69e-40	155.0	COG4223@1|root,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,1RYCQ@1236|Gammaproteobacteria,1XDAZ@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1631)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631
k59_673899_1	1049564.TevJSym_am00780	3.45e-100	298.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,1RPBB@1236|Gammaproteobacteria,1J4QD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
k59_1202522_1	1283287.KB822576_gene3478	1.75e-55	177.0	COG0242@1|root,COG0242@2|Bacteria,2GJ87@201174|Actinobacteria,4DQIB@85009|Propionibacteriales	201174|Actinobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_1202522_2	743718.Isova_1596	4.05e-17	79.3	COG0223@1|root,COG0223@2|Bacteria,2GKH5@201174|Actinobacteria,4F37G@85017|Promicromonosporaceae	201174|Actinobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_394378_1	1198232.CYCME_2355	6.96e-59	197.0	COG3746@1|root,COG3746@2|Bacteria,1Q6EB@1224|Proteobacteria,1TA7N@1236|Gammaproteobacteria,4620B@72273|Thiotrichales	72273|Thiotrichales	P	Phosphate-selective porin O and P	-	-	-	ko:K07221	-	-	-	-	ko00000,ko02000	1.B.5.1	-	-	Porin_O_P
k59_1267576_1	572477.Alvin_0577	3.22e-64	205.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,1WWXV@135613|Chromatiales	135613|Chromatiales	IQ	Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_43982_1	1565129.JSFF01000009_gene1815	2.84e-63	214.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,2Q9UE@267890|Shewanellaceae	1236|Gammaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_438594_1	1026882.MAMP_01332	9.29e-29	110.0	COG0810@1|root,COG0810@2|Bacteria,1PEDH@1224|Proteobacteria,1RRNT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
k59_43986_1	272630.MexAM1_META1p2555	2.57e-07	51.6	COG3193@1|root,COG3193@2|Bacteria,1REF5@1224|Proteobacteria,2U5M2@28211|Alphaproteobacteria,1JVH2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
k59_277035_1	1101190.ARWB01000001_gene1245	2.73e-15	75.9	COG0045@1|root,COG0045@2|Bacteria,1QS4S@1224|Proteobacteria,2U29P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the succinate malate CoA ligase beta subunit family	-	-	6.2.1.5,6.2.1.9	ko:K01903,ko:K14067	ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00346,M00374,M00620	R00405,R01256,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_277035_2	666684.AfiDRAFT_1882	8.77e-100	298.0	COG0074@1|root,COG0074@2|Bacteria,1R4HY@1224|Proteobacteria,2U1QN@28211|Alphaproteobacteria,3K3HA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	-	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA,Succ_CoA_lig
k59_394387_1	1121015.N789_09600	5.56e-06	55.1	COG1680@1|root,COG1680@2|Bacteria,1MY01@1224|Proteobacteria,1RNUI@1236|Gammaproteobacteria,1X480@135614|Xanthomonadales	135614|Xanthomonadales	V	beta-lactamase	ampC3	-	3.5.2.6	ko:K01467	ko01501,ko02020,map01501,map02020	M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000	-	-	-	Beta-lactamase
k59_849674_1	519989.ECTPHS_08708	2.76e-139	409.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1WXCF@135613|Chromatiales	135613|Chromatiales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k59_922833_2	1049564.TevJSym_ab01320	1.15e-58	193.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,1RYCJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
k59_981887_1	1158165.KB898871_gene2294	9.53e-12	60.1	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,1S9AI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
k59_981887_2	521719.ATXQ01000004_gene1813	2.01e-77	244.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1YDH1@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022607,GO:0022611,GO:0022613,GO:0022618,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0043021,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0065003,GO:0065007,GO:0070925,GO:0071826,GO:0071840,GO:0090069,GO:0090071,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_673910_1	529709.PYCH_04690	0.000156	48.5	COG0517@1|root,arCOG00601@2157|Archaea,2XT75@28890|Euryarchaeota,242RR@183968|Thermococci	183968|Thermococci	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_43990_1	236097.ADG881_2472	5.34e-08	53.9	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1XHSI@135619|Oceanospirillales	135619|Oceanospirillales	P	Trk system potassium uptake protein	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_43990_2	870187.Thini_2510	4.06e-105	321.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,45ZP9@72273|Thiotrichales	72273|Thiotrichales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_1862403_1	1123401.JHYQ01000005_gene263	1.66e-70	223.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,1SQ2U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Thiosulfate-oxidizing multienzyme system protein SoxA	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1787252_1	1234364.AMSF01000049_gene2023	6.21e-28	110.0	COG3065@1|root,COG3065@2|Bacteria,1MZ8C@1224|Proteobacteria,1S9UB@1236|Gammaproteobacteria,1X6PD@135614|Xanthomonadales	135614|Xanthomonadales	M	Outer membrane lipoprotein	-	-	-	ko:K07285	-	-	-	-	ko00000	-	-	-	Slp
k59_1553415_1	1121373.KB903621_gene1819	7.94e-59	203.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,47KIX@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolase family 3 C-terminal domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_922839_1	1122164.JHWF01000034_gene2219	6.14e-39	139.0	COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,1RNYV@1236|Gammaproteobacteria,1JCI0@118969|Legionellales	118969|Legionellales	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
k59_922839_2	666685.R2APBS1_0560	1.32e-89	270.0	COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,1S2I8@1236|Gammaproteobacteria,1X3PP@135614|Xanthomonadales	135614|Xanthomonadales	O	maleylacetoacetate isomerase	uptB	-	5.2.1.2	ko:K01800	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R03181	RC00867	ko00000,ko00001,ko00002,ko01000	-	-	-	GST_C_2,GST_N,GST_N_3
k59_922839_3	861299.J421_1235	6.09e-11	62.0	COG0637@1|root,COG0637@2|Bacteria,1ZTWJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_1267588_1	1265505.ATUG01000002_gene1358	1.92e-96	293.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,43060@68525|delta/epsilon subdivisions,2WVAA@28221|Deltaproteobacteria,2MNEB@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_555941_1	870187.Thini_4364	2.46e-22	94.4	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,45ZSJ@72273|Thiotrichales	72273|Thiotrichales	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k59_555941_2	472759.Nhal_1926	9.51e-60	195.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,1WW5P@135613|Chromatiales	135613|Chromatiales	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
k59_1334113_1	367299.JOEE01000004_gene1012	2.6e-136	402.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,4FEPZ@85021|Intrasporangiaceae	201174|Actinobacteria	I	Dehydrogenase	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_1787254_1	83406.HDN1F_07880	1.61e-95	285.0	COG2521@1|root,COG2521@2|Bacteria,1Q0VI@1224|Proteobacteria,1S18J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Methyl-transferase	-	-	-	ko:K06983	-	-	-	-	ko00000	-	-	-	Methyltransf_11,Methyltransf_30
k59_1140004_1	880072.Desac_2695	3.12e-08	54.7	COG4715@1|root,COG4715@2|Bacteria	2|Bacteria	S	zinc ion binding	CP_1020	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
k59_1140004_2	880072.Desac_2694	1.93e-24	103.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42N2T@68525|delta/epsilon subdivisions,2WMYV@28221|Deltaproteobacteria,2MRZQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1672537_1	751994.AGIG01000030_gene749	4.71e-41	142.0	COG3193@1|root,COG3193@2|Bacteria,1REZG@1224|Proteobacteria,1S5K5@1236|Gammaproteobacteria,1JB26@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
k59_277056_1	349521.HCH_06262	3.95e-76	243.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1XHIH@135619|Oceanospirillales	135619|Oceanospirillales	J	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
k59_673921_1	1137799.GZ78_03255	1.91e-06	52.4	COG1934@1|root,COG1934@2|Bacteria,1N776@1224|Proteobacteria,1RPM7@1236|Gammaproteobacteria,1XMAP@135619|Oceanospirillales	135619|Oceanospirillales	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
k59_849690_2	155515.JP36_07730	3.52e-14	68.9	COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,1Y91Y@135625|Pasteurellales	135625|Pasteurellales	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
k59_1729969_1	172088.AUGA01000004_gene3909	9.27e-97	288.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2TRZJ@28211|Alphaproteobacteria,3JR0V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0276 family	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
k59_1502012_1	882378.RBRH_00290	4.01e-112	333.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2VJ7Z@28216|Betaproteobacteria,1K0VF@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the argininosuccinate synthase family. Type	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_1862420_1	2340.JV46_14290	4.16e-123	370.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_100928_1	519989.ECTPHS_03642	1.7e-131	391.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1WW9D@135613|Chromatiales	135613|Chromatiales	L	single-stranded-DNA-specific exonuclease RecJ	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_44014_1	643648.Slip_1606	1.01e-44	157.0	COG1484@1|root,COG1484@2|Bacteria,1UYIT@1239|Firmicutes,24DFX@186801|Clostridia,42KKU@68298|Syntrophomonadaceae	186801|Clostridia	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_1021432_1	1265505.ATUG01000002_gene2077	9.07e-85	269.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WIX6@28221|Deltaproteobacteria,2MHSF@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
k59_1553433_1	1454010.JEOE01000043_gene2571	1.54e-173	495.0	COG1875@1|root,COG1875@2|Bacteria,2GK8U@201174|Actinobacteria,4F0EF@85016|Cellulomonadaceae	201174|Actinobacteria	T	SMART Nucleotide binding protein PINc	phoH2	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
k59_1611596_1	1121921.KB898708_gene1533	7.68e-76	262.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,2PN2Z@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	L	SMC proteins Flexible Hinge Domain	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_1021440_1	395493.BegalDRAFT_1884	1.02e-132	401.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,45ZUB@72273|Thiotrichales	72273|Thiotrichales	C	NADH-quinone oxidoreductase	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1093351_1	419947.MRA_2115	4.38e-86	286.0	COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria,235KG@1762|Mycobacteriaceae	201174|Actinobacteria	KL	SNF2 family N-terminal domain	helZ	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
k59_614604_2	1123247.AUIJ01000009_gene2997	2.83e-13	65.1	COG3313@1|root,COG3313@2|Bacteria,1NGD5@1224|Proteobacteria,2UJKX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Fe-S protein	-	-	-	ko:K06938	-	-	-	-	ko00000	-	-	-	DUF1289
k59_44048_1	1041139.KB902679_gene2027	2.04e-07	49.7	COG1846@1|root,COG1846@2|Bacteria,1RJNN@1224|Proteobacteria,2UCG5@28211|Alphaproteobacteria,4BENU@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
k59_44048_2	411684.HPDFL43_19537	2.6e-41	145.0	COG0791@1|root,COG0791@2|Bacteria,1MW03@1224|Proteobacteria,2TSFG@28211|Alphaproteobacteria,43IB6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,SH3_3
k59_786627_1	887062.HGR_15469	9.36e-73	239.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,4AAP6@80864|Comamonadaceae	28216|Betaproteobacteria	V	Transporter, hydrophobe amphiphile efflux-1 (HAE1) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1862461_1	460265.Mnod_3938	1.07e-30	118.0	COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2TUGE@28211|Alphaproteobacteria,1JWWY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_673949_1	56780.SYN_02987	1.2e-76	242.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,42S30@68525|delta/epsilon subdivisions,2WQ5S@28221|Deltaproteobacteria,2MRTS@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1093358_1	394503.Ccel_2377	1.98e-05	47.4	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,36UKQ@31979|Clostridiaceae	186801|Clostridia	Q	Beta-ketoacyl synthase	-	-	-	-	-	-	-	-	-	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
k59_1334166_1	1027273.GZ77_08175	3.15e-53	189.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1XHDK@135619|Oceanospirillales	135619|Oceanospirillales	C	2-oxoglutarate dehydrogenase	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_439387_1	1274374.CBLK010000029_gene2978	1.59e-55	186.0	COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,4HBCU@91061|Bacilli,26QJX@186822|Paenibacillaceae	91061|Bacilli	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
k59_439387_2	913325.N799_05610	4.06e-15	75.1	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1X3CE@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_1268367_1	1123371.ATXH01000011_gene98	4.24e-26	115.0	COG2067@1|root,COG2067@2|Bacteria,2GHBE@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_787223_1	768671.ThimaDRAFT_3683	7.17e-49	160.0	2D3GG@1|root,32TEX@2|Bacteria,1N6JV@1224|Proteobacteria,1SEDU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1094124_1	367299.JOEE01000009_gene254	2.28e-108	315.0	COG2813@1|root,COG2813@2|Bacteria,2IFG7@201174|Actinobacteria,4FGDZ@85021|Intrasporangiaceae	201174|Actinobacteria	J	16S RNA G1207 methylase RsmC	rsmC	-	2.1.1.172	ko:K00564	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	MTS
k59_994773_1	575540.Isop_1882	2.82e-26	112.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_11,TPR_12,TPR_8,WD40
k59_682552_1	639282.DEFDS_1851	6.42e-78	248.0	COG0439@1|root,COG0439@2|Bacteria	2|Bacteria	I	biotin carboxylase activity	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
k59_55622_1	1449049.JONW01000009_gene4465	2.58e-07	53.9	2APUG@1|root,31EYZ@2|Bacteria,1R3K7@1224|Proteobacteria,2U03X@28211|Alphaproteobacteria,2KGMT@204458|Caulobacterales	204458|Caulobacterales	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
k59_622822_1	46429.BV95_01468	2.35e-32	129.0	COG0739@1|root,COG2304@1|root,COG2911@1|root,COG0739@2|Bacteria,COG2304@2|Bacteria,COG2911@2|Bacteria,1P8N9@1224|Proteobacteria,2TWAF@28211|Alphaproteobacteria,2KEDJ@204457|Sphingomonadales	204457|Sphingomonadales	M	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1210546_1	504832.OCAR_5028	7.48e-24	100.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TSI2@28211|Alphaproteobacteria,3JQY0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	nosF	-	-	ko:K01990,ko:K19340	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	ABC_tran
k59_1210546_2	1121033.AUCF01000004_gene4664	6.07e-64	209.0	COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,2TQTC@28211|Alphaproteobacteria,2JRC5@204441|Rhodospirillales	204441|Rhodospirillales	P	Periplasmic copper-binding protein (NosD)	-	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
k59_330033_1	1265505.ATUG01000002_gene1619	1.03e-70	239.0	COG1148@1|root,COG2204@1|root,COG1148@2|Bacteria,COG2204@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MI9Y@213118|Desulfobacterales	28221|Deltaproteobacteria	CT	NAD(P)-binding Rossmann-like domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FAD_oxidored,Fer4,Fer4_7,NAD_binding_8,Pyr_redox_2,Response_reg
k59_1875489_1	667014.Thein_2037	4.54e-22	91.3	2EAAE@1|root,334ER@2|Bacteria,2GHMY@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_857823_1	1121468.AUBR01000003_gene622	1.24e-14	71.2	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,42GCN@68295|Thermoanaerobacterales	186801|Clostridia	K	TIGRFAM transcriptional regulator, Rrf2 family	cymR	-	-	-	-	-	-	-	-	-	-	-	Rrf2
k59_1445787_1	237368.SCABRO_02446	8.61e-61	210.0	COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,2IWSR@203682|Planctomycetes	203682|Planctomycetes	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS,PAS_10,PAS_3,PAS_4,Response_reg
k59_1386054_1	278957.ABEA03000050_gene155	9.73e-30	125.0	COG1450@1|root,COG1450@2|Bacteria,46TXY@74201|Verrucomicrobia,3K7FR@414999|Opitutae	414999|Opitutae	NU	Type II and III secretion system protein	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin
k59_1029513_1	666685.R2APBS1_0795	7.83e-111	330.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,1RMP0@1236|Gammaproteobacteria,1X4KU@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_994783_1	1255043.TVNIR_2986	4.35e-40	134.0	COG4576@1|root,COG4576@2|Bacteria,1N7B1@1224|Proteobacteria,1S9JX@1236|Gammaproteobacteria,1WZ5P@135613|Chromatiales	135613|Chromatiales	CQ	Ethanolamine utilisation protein EutN/carboxysome	-	-	-	-	-	-	-	-	-	-	-	-	EutN_CcmL
k59_994783_2	1249627.D779_1743	5.39e-45	146.0	COG4576@1|root,COG4576@2|Bacteria,1MZNS@1224|Proteobacteria,1S9MK@1236|Gammaproteobacteria,1WYX9@135613|Chromatiales	135613|Chromatiales	CQ	PFAM Ethanolamine utilization protein EutN carboxysome structural protein Ccml	-	-	-	-	-	-	-	-	-	-	-	-	EutN_CcmL
k59_1147377_1	446468.Ndas_0057	1.65e-57	194.0	COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,2GITG@201174|Actinobacteria,4EGE3@85012|Streptosporangiales	201174|Actinobacteria	FL	AlkA N-terminal domain	ada	-	3.2.2.21	ko:K13529	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
k59_622831_1	1304865.JAGF01000001_gene1453	8.04e-31	115.0	COG1863@1|root,COG1863@2|Bacteria,2IQD6@201174|Actinobacteria,4F1CC@85016|Cellulomonadaceae	201174|Actinobacteria	P	Na+/H+ ion antiporter subunit	mrpE	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
k59_622831_2	471853.Bcav_3816	7.3e-25	103.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria	201174|Actinobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	mrpD	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_857831_1	1499967.BAYZ01000171_gene5534	1.62e-27	113.0	COG0589@1|root,COG1475@1|root,COG0589@2|Bacteria,COG1475@2|Bacteria,2NS1X@2323|unclassified Bacteria	2|Bacteria	K	DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF4032,ParBc,Usp
k59_935530_1	1268237.G114_01354	3.2e-29	123.0	COG4206@1|root,COG4206@2|Bacteria,1R47X@1224|Proteobacteria,1T1X7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1738332_1	1049564.TevJSym_bi00190	8.51e-80	254.0	COG1509@1|root,COG1509@2|Bacteria,1NG2M@1224|Proteobacteria,1SR2C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	lysine 2,3-aminomutase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_113934_1	266835.14025227	6.23e-110	323.0	COG0510@1|root,COG0510@2|Bacteria,1N77Z@1224|Proteobacteria,2TRW6@28211|Alphaproteobacteria,43MNN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Choline ethanolamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH,Choline_kinase
k59_1620049_1	156889.Mmc1_0375	5.01e-82	267.0	COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,1NZZ9@1224|Proteobacteria,2TUXR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	ABC transporter permease	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
k59_1620049_2	1515746.HR45_18370	8.21e-67	213.0	COG1131@1|root,COG1131@2|Bacteria,1QXFI@1224|Proteobacteria,1T3AJ@1236|Gammaproteobacteria,2Q9FF@267890|Shewanellaceae	1236|Gammaproteobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1029537_1	590998.Celf_0649	4.85e-105	310.0	COG1842@1|root,COG1842@2|Bacteria,2GJGD@201174|Actinobacteria,4F0H5@85016|Cellulomonadaceae	201174|Actinobacteria	KT	PspA/IM30 family	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
k59_1147395_1	1121405.dsmv_0558	6.65e-90	280.0	COG2069@1|root,COG2069@2|Bacteria,1QS8G@1224|Proteobacteria,437H2@68525|delta/epsilon subdivisions,2WKVX@28221|Deltaproteobacteria,2MI1T@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase delta subunit	-	-	2.1.1.245	ko:K00194	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD
k59_994816_1	323848.Nmul_A0735	3.33e-62	200.0	COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,2VR0S@28216|Betaproteobacteria,372JA@32003|Nitrosomonadales	28216|Betaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_996000_1	1121448.DGI_0733	9.53e-30	114.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NTG@68525|delta/epsilon subdivisions,2WKHW@28221|Deltaproteobacteria,2M8FK@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	PFAM ABC transporter related	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_1511996_1	396588.Tgr7_2714	1.15e-74	251.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1WWF6@135613|Chromatiales	135613|Chromatiales	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
k59_1348516_1	1335757.SPICUR_06635	1.61e-05	46.2	COG1249@1|root,COG1249@2|Bacteria,1MVVE@1224|Proteobacteria,1RMJT@1236|Gammaproteobacteria,1WWC2@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	sthA	-	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_408662_1	550540.Fbal_3296	2.23e-67	214.0	COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,1RN28@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs	dusA	GO:0002943,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	-	ko:K05539	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_936733_1	1162668.LFE_2322	1.14e-62	210.0	COG0008@1|root,COG0008@2|Bacteria,3J0CJ@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_447867_1	760011.Spico_0421	8.5e-24	101.0	COG5002@1|root,COG5002@2|Bacteria,2J6AJ@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,sCache_like
k59_447867_2	684719.HIMB114_00009780	6.16e-84	260.0	COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,2TR1C@28211|Alphaproteobacteria,4BPI3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	PBP superfamily domain	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_115170_1	1035308.AQYY01000002_gene430	3.84e-63	210.0	COG1022@1|root,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,25E9H@186801|Clostridia,265SV@186807|Peptococcaceae	186801|Clostridia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_1512005_2	387093.SUN_1729	1.28e-69	213.0	COG1943@1|root,COG1943@2|Bacteria,1RF1K@1224|Proteobacteria,42VRT@68525|delta/epsilon subdivisions,2YQZ0@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	L	COGs COG1943 Transposase and inactivated derivatives	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_742103_2	1304865.JAGF01000001_gene2476	3.99e-24	100.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,2GJ0A@201174|Actinobacteria,4F0FS@85016|Cellulomonadaceae	201174|Actinobacteria	E	TIGRFAM glutamate synthase, NADH NADPH, small subunit	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,NAD_binding_1,Pyr_redox_2
k59_1512007_1	1179778.PMM47T1_16208	5.89e-53	186.0	COG0128@1|root,COG0287@1|root,COG0128@2|Bacteria,COG0287@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	1.3.1.12,1.3.1.43,2.5.1.19	ko:K00210,ko:K00220,ko:K00800	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00022,M00025,M00040	R00732,R01728,R03460	RC00125,RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase,PDH
k59_1876796_1	360910.BAV2542	1.25e-12	68.9	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,3T3EE@506|Alcaligenaceae	28216|Betaproteobacteria	E	Extracellular solute-binding protein, family 5 middle family protein 22	oppA	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
k59_1876796_2	314278.NB231_16698	1.64e-79	246.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1WXAY@135613|Chromatiales	135613|Chromatiales	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1148138_2	1397666.RS24_00486	1.67e-80	241.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2U5FM@28211|Alphaproteobacteria,4BQ3M@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
k59_1148138_3	1207063.P24_10221	6.66e-05	44.7	COG2050@1|root,COG2050@2|Bacteria,1MZRJ@1224|Proteobacteria,2U9BM@28211|Alphaproteobacteria,2JTJ5@204441|Rhodospirillales	204441|Rhodospirillales	Q	protein, possibly involved in aromatic compounds catabolism	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_1103320_1	748247.AZKH_2909	8.83e-70	228.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2VIEB@28216|Betaproteobacteria,2KY1I@206389|Rhodocyclales	206389|Rhodocyclales	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
k59_447881_2	522306.CAP2UW1_2689	5.01e-21	92.0	COG0224@1|root,COG0224@2|Bacteria,1RIE5@1224|Proteobacteria,2VYNF@28216|Betaproteobacteria	28216|Betaproteobacteria	C	ATP synthase	-	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_1512010_1	1206101.AZXC01000010_gene23	3.46e-44	155.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
k59_683439_1	1280947.HY30_05580	7.62e-12	67.4	COG2204@1|root,COG2204@2|Bacteria,1MWW5@1224|Proteobacteria,2TXAZ@28211|Alphaproteobacteria,43X5S@69657|Hyphomonadaceae	28211|Alphaproteobacteria	T	COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain	pspF	-	-	ko:K03974	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,Sigma54_activat
k59_996035_1	247490.KSU1_D0588	7.14e-10	57.8	COG3431@1|root,COG3431@2|Bacteria,2J3HB@203682|Planctomycetes	203682|Planctomycetes	S	Phosphate-starvation-inducible E	-	-	-	-	-	-	-	-	-	-	-	-	PsiE
k59_1348553_1	1121405.dsmv_3672	4.4e-59	199.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2WJ7H@28221|Deltaproteobacteria,2MIPF@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC,GARS_A,GARS_C,GARS_N
k59_1348553_2	1230342.CTM_24643	2.52e-19	88.2	COG0009@1|root,COG0009@2|Bacteria,1TP1I@1239|Firmicutes,248HS@186801|Clostridia,36EVH@31979|Clostridiaceae	186801|Clostridia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	sua	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
k59_289348_1	1123073.KB899241_gene1773	5.16e-78	246.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1X34W@135614|Xanthomonadales	135614|Xanthomonadales	C	NADP transhydrogenase	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_858592_2	1385521.N803_03610	5.72e-62	202.0	COG0582@1|root,COG0582@2|Bacteria,2GMMI@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	int	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
k59_936769_2	1502852.FG94_01328	1.03e-42	148.0	COG4106@1|root,COG4106@2|Bacteria,1QUZE@1224|Proteobacteria,2VSHF@28216|Betaproteobacteria,474Y9@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	TPMT
k59_408693_1	1379698.RBG1_1C00001G1616	2.97e-68	236.0	COG0515@1|root,COG0515@2|Bacteria,2NQWH@2323|unclassified Bacteria	2|Bacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_8
k59_565137_1	991905.SL003B_3716	6.29e-12	68.9	COG1092@1|root,COG1092@2|Bacteria,1QSD4@1224|Proteobacteria,2TUFT@28211|Alphaproteobacteria,4BPRZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	S-adenosylmethionine-dependent methyltransferase	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95,Methyltrans_SAM
k59_447893_1	382464.ABSI01000012_gene2198	8.61e-49	176.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C
k59_623723_1	101510.RHA1_ro03946	8.7e-06	47.8	COG1073@1|root,COG1073@2|Bacteria,2GNB6@201174|Actinobacteria,4FWQ5@85025|Nocardiaceae	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,Hydrolase_4
k59_742117_1	471853.Bcav_1262	3.31e-114	337.0	COG1162@1|root,COG1162@2|Bacteria,2GJ37@201174|Actinobacteria	201174|Actinobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
k59_1277857_1	1499967.BAYZ01000154_gene1524	4.64e-113	334.0	COG2230@1|root,COG2230@2|Bacteria,2NQ94@2323|unclassified Bacteria	2|Bacteria	M	Mycolic acid cyclopropane synthetase	cfa	-	2.1.1.317,2.1.1.79	ko:K00574,ko:K20238	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_1348569_2	572477.Alvin_0834	1.45e-159	456.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1WWTF@135613|Chromatiales	135613|Chromatiales	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
k59_56645_1	395493.BegalDRAFT_1819	2.94e-49	168.0	COG0789@1|root,COG0789@2|Bacteria,1R9SN@1224|Proteobacteria,1S78T@1236|Gammaproteobacteria,463IS@72273|Thiotrichales	72273|Thiotrichales	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
k59_506590_1	522306.CAP2UW1_0195	1.17e-108	331.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VNNI@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_213554_1	1158756.AQXQ01000011_gene655	4.74e-54	181.0	COG0398@1|root,COG0607@1|root,COG0398@2|Bacteria,COG0607@2|Bacteria,1MVF3@1224|Proteobacteria,1SZBI@1236|Gammaproteobacteria	1224|Proteobacteria	P	SNARE associated Golgi protein	ydjX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Rhodanese,SNARE_assoc
k59_289369_1	768671.ThimaDRAFT_3960	1.38e-100	300.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1WXNB@135613|Chromatiales	135613|Chromatiales	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_936793_2	765912.Thimo_0131	1.56e-42	149.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,1RNJW@1236|Gammaproteobacteria,1WZUW@135613|Chromatiales	135613|Chromatiales	Q	PFAM toluene tolerance	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
k59_936793_3	380394.Lferr_1061	6.43e-64	211.0	COG1109@1|root,COG1109@2|Bacteria,1MUB3@1224|Proteobacteria,1RNFZ@1236|Gammaproteobacteria,2NCJ0@225057|Acidithiobacillales	225057|Acidithiobacillales	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_565167_1	1304865.JAGF01000001_gene1614	3.84e-06	48.1	COG0493@1|root,COG4624@1|root,COG0493@2|Bacteria,COG4624@2|Bacteria,2GJ0A@201174|Actinobacteria,4F0FS@85016|Cellulomonadaceae	201174|Actinobacteria	E	TIGRFAM glutamate synthase, NADH NADPH, small subunit	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2
k59_565167_2	1304865.JAGF01000001_gene1613	6.72e-39	141.0	COG0715@1|root,COG0715@2|Bacteria,2H0SV@201174|Actinobacteria	201174|Actinobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2,Phosphonate-bd,VitK2_biosynth
k59_742151_1	1304865.JAGF01000001_gene1397	5.86e-88	272.0	COG0508@1|root,COG0508@2|Bacteria,2GM0D@201174|Actinobacteria,4F0G9@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM catalytic domain-containing protein of components of various dehydrogenase complexes	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_447926_1	1288494.EBAPG3_1330	9.94e-53	184.0	COG3359@1|root,COG3359@2|Bacteria,1R5KG@1224|Proteobacteria	1224|Proteobacteria	L	Exonuclease	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
k59_1681605_2	746697.Aeqsu_2113	2.13e-23	102.0	COG4409@1|root,COG4409@2|Bacteria,4NI5M@976|Bacteroidetes,1HYDS@117743|Flavobacteriia	976|Bacteroidetes	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
k59_1562691_1	1121015.N789_09135	6.77e-17	76.6	2DP15@1|root,3303T@2|Bacteria,1N7NN@1224|Proteobacteria,1S90P@1236|Gammaproteobacteria,1X82G@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4426)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4426
k59_755715_1	1379698.RBG1_1C00001G0434	3.32e-05	47.8	COG0812@1|root,COG0812@2|Bacteria,2NPHQ@2323|unclassified Bacteria	2|Bacteria	M	Cell wall formation	murB	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
k59_755715_2	1121403.AUCV01000017_gene4526	8.21e-67	213.0	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,42M4E@68525|delta/epsilon subdivisions,2WKFT@28221|Deltaproteobacteria,2MIBF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
k59_1400257_1	323848.Nmul_A2711	5.58e-09	56.2	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,2VGZ7@28216|Betaproteobacteria,372MM@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008144,GO:0016829,GO:0016840,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:1901681,GO:1904047	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
k59_1400257_2	519989.ECTPHS_02204	3.66e-17	82.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,1WW2G@135613|Chromatiales	135613|Chromatiales	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri,YfiO
k59_755723_1	1445613.JALM01000036_gene2852	4.98e-92	281.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4DXDP@85010|Pseudonocardiales	201174|Actinobacteria	I	Belongs to the thiolase family	fadA1	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_226753_1	631362.Thi970DRAFT_00641	2.36e-106	316.0	COG1363@1|root,COG1363@2|Bacteria,1MXEU@1224|Proteobacteria,1RSHP@1236|Gammaproteobacteria,1WWZP@135613|Chromatiales	135613|Chromatiales	G	peptidase M42	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
k59_226756_1	96561.Dole_2980	4.97e-31	119.0	COG0517@1|root,COG1993@1|root,COG0517@2|Bacteria,COG1993@2|Bacteria,1N0EM@1224|Proteobacteria,43BS4@68525|delta/epsilon subdivisions,2X72X@28221|Deltaproteobacteria,2MPVN@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Uncharacterized ACR, COG1993	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF190
k59_226756_2	1121405.dsmv_3537	4.95e-09	55.1	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,42V4I@68525|delta/epsilon subdivisions,2WRJJ@28221|Deltaproteobacteria,2MKW0@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
k59_1634920_1	768671.ThimaDRAFT_0204	1.9e-79	254.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales	135613|Chromatiales	I	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_226766_1	315456.RF_0570	3.12e-14	79.7	COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,2U0EG@28211|Alphaproteobacteria,47F4A@766|Rickettsiales	766|Rickettsiales	S	hmm tigr01630	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6C
k59_517823_1	1121106.JQKB01000003_gene2483	6.15e-102	300.0	COG0778@1|root,COG0778@2|Bacteria,1NCBD@1224|Proteobacteria	1224|Proteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_1046278_1	639282.DEFDS_0829	7.21e-54	174.0	COG1528@1|root,COG1528@2|Bacteria,2GFDZ@200930|Deferribacteres	200930|Deferribacteres	C	Iron-storage protein	-	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
k59_1634935_1	1049564.TevJSym_ac00110	8.65e-72	225.0	COG2863@1|root,COG2863@2|Bacteria,1R6DK@1224|Proteobacteria	1224|Proteobacteria	C	Pfam cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_344259_1	384676.PSEEN1796	7.59e-66	231.0	COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	P-type atpase	ccoI	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_1225432_1	1095767.CAHD01000208_gene133	3.91e-145	422.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2GIWJ@201174|Actinobacteria,4F0NM@85016|Cellulomonadaceae	201174|Actinobacteria	H	catalyzes the conversion of	ribA	-	3.5.4.25,4.1.99.12	ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2,Lum_binding
k59_873498_1	1442599.JAAN01000020_gene2572	1.02e-74	236.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1X39G@135614|Xanthomonadales	135614|Xanthomonadales	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
k59_168783_1	395493.BegalDRAFT_0164	7e-72	230.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,4604I@72273|Thiotrichales	72273|Thiotrichales	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,Pribosyltran
k59_168783_2	2340.JV46_26510	1.23e-26	103.0	COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria,1J6GJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane protein, required for colicin V production	cvpA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
k59_1806578_1	1121918.ARWE01000001_gene954	2.43e-65	224.0	COG3210@1|root,COG3391@1|root,COG3210@2|Bacteria,COG3391@2|Bacteria,1R4VM@1224|Proteobacteria,43CFZ@68525|delta/epsilon subdivisions,2WQIB@28221|Deltaproteobacteria,43TE1@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Concanavalin A-like lectin/glucanases superfamily	-	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	Laminin_G_3
k59_577262_1	690597.JH730978_gene5225	1.5e-59	194.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1YPNR@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006780,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046394,GO:0046483,GO:0046501,GO:0046502,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO3734,iSBO_1134.SBO_4018	URO-D
k59_1225440_1	1304885.AUEY01000022_gene3396	3.64e-79	245.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2MII7@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	PFAM type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_1634955_1	765913.ThidrDRAFT_1888	1.14e-49	175.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1WW15@135613|Chromatiales	135613|Chromatiales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_1576926_1	631362.Thi970DRAFT_04623	1.32e-59	195.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1WXAD@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_1576926_2	631362.Thi970DRAFT_04624	7.04e-60	186.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,1WYQC@135613|Chromatiales	135613|Chromatiales	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
k59_1576926_3	545264.KB898747_gene513	1.03e-23	91.3	COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,1WZBU@135613|Chromatiales	135613|Chromatiales	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
k59_1576926_4	765912.Thimo_2827	4.52e-34	121.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,1S4E6@1236|Gammaproteobacteria,1WWSS@135613|Chromatiales	135613|Chromatiales	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
k59_636304_2	1121085.AUCI01000002_gene4021	3.49e-17	74.7	29SGJ@1|root,30DMJ@2|Bacteria,1UBFB@1239|Firmicutes,4IMU0@91061|Bacilli,1ZKUH@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1225461_1	1454010.JEOE01000004_gene69	1.23e-66	212.0	COG1131@1|root,COG1131@2|Bacteria,2IH64@201174|Actinobacteria,4F2FJ@85016|Cellulomonadaceae	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1225461_2	1121952.ATXT01000013_gene2421	1.55e-34	132.0	COG1131@1|root,COG1131@2|Bacteria,2ICIF@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990,ko:K13926	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1695759_1	879212.DespoDRAFT_01391	4.81e-109	328.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,42MZN@68525|delta/epsilon subdivisions,2WJGK@28221|Deltaproteobacteria,2MHPF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_696192_1	349124.Hhal_1836	1.21e-72	243.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1WXI8@135613|Chromatiales	135613|Chromatiales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_755802_2	76114.ebB47	3.51e-72	219.0	2CD0I@1|root,32RWS@2|Bacteria,1N0MC@1224|Proteobacteria,2VS3E@28216|Betaproteobacteria,2KYRB@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain of unknown function (DUF4399)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4399
k59_755802_3	1218084.BBJK01000130_gene7139	3.56e-14	67.8	2CD0I@1|root,3239M@2|Bacteria,1MYFR@1224|Proteobacteria,2VR94@28216|Betaproteobacteria,1K6ZT@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4399)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4399
k59_1159846_1	1121405.dsmv_3709	3.19e-78	243.0	COG0535@1|root,COG0535@2|Bacteria,1R4SH@1224|Proteobacteria,42NZR@68525|delta/epsilon subdivisions,2WKQA@28221|Deltaproteobacteria,2MHSP@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
k59_755805_1	748658.KB907315_gene2597	1.83e-52	181.0	COG0526@1|root,COG0526@2|Bacteria,1MWDE@1224|Proteobacteria,1S0NV@1236|Gammaproteobacteria,1WXDD@135613|Chromatiales	135613|Chromatiales	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
k59_1400397_1	335543.Sfum_0272	1.04e-14	75.1	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42V72@68525|delta/epsilon subdivisions,2WRHE@28221|Deltaproteobacteria,2MSA6@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1046382_1	935839.JAGJ01000011_gene411	2.19e-41	147.0	COG0438@1|root,COG0438@2|Bacteria,2I5RJ@201174|Actinobacteria,4F40A@85017|Promicromonosporaceae	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
k59_1159861_1	395493.BegalDRAFT_1383	5.64e-117	359.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,45ZRS@72273|Thiotrichales	72273|Thiotrichales	C	TIGRFAM nitrite reductase NAD(P)H , large subunit	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
k59_1635013_1	105559.Nwat_0690	1.65e-20	87.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,1WWJX@135613|Chromatiales	135613|Chromatiales	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
k59_1635013_2	1282356.H045_19275	5.36e-27	109.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,1YM23@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	yggW	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_804421_1	926550.CLDAP_29120	1.3e-145	416.0	COG0667@1|root,COG0667@2|Bacteria,2G5V3@200795|Chloroflexi	200795|Chloroflexi	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_636348_1	1121438.JNJA01000005_gene1149	2.32e-15	77.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M97@68525|delta/epsilon subdivisions,2WJB4@28221|Deltaproteobacteria,2M9HU@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	hmcB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4,Fer4_7
k59_636348_2	96561.Dole_2252	9.06e-46	158.0	COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42P2Q@68525|delta/epsilon subdivisions,2WKC2@28221|Deltaproteobacteria,2MJCP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Polysulphide reductase, NrfD	hmcC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	NrfD
k59_873593_1	1121434.AULY01000010_gene2342	3.66e-33	121.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,42MZP@68525|delta/epsilon subdivisions,2WJ1Z@28221|Deltaproteobacteria,2M8GT@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_873593_2	161156.JQKW01000011_gene913	3.42e-19	85.9	COG0244@1|root,COG0244@2|Bacteria,2GH1K@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_344336_1	1121405.dsmv_2900	2.94e-114	334.0	COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,42NTS@68525|delta/epsilon subdivisions,2WK04@28221|Deltaproteobacteria,2MJC0@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM Methylenetetrahydrofolate reductase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,MTHFR
k59_1225512_1	1463917.JODC01000050_gene6	1.53e-72	245.0	COG0604@1|root,COG3321@1|root,COG0604@2|Bacteria,COG3321@2|Bacteria,2H477@201174|Actinobacteria	201174|Actinobacteria	Q	polyketide synthase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2,Acyl_transf_1,Docking,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
k59_1635030_1	1150474.JQJI01000024_gene1584	3.79e-10	61.6	COG0008@1|root,COG0008@2|Bacteria,2GBZU@200918|Thermotogae	200918|Thermotogae	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX2	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_1046412_2	1157640.AQWO01000001_gene6395	2.63e-54	181.0	COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_460118_1	1278309.KB907100_gene2320	1.42e-87	269.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1XH97@135619|Oceanospirillales	135619|Oceanospirillales	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_226879_1	717785.HYPMC_2915	5.47e-15	68.9	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2UC5G@28211|Alphaproteobacteria,3N7A9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_1695825_2	935839.JAGJ01000010_gene337	1.62e-21	94.0	2DME2@1|root,32QVN@2|Bacteria,2HM0F@201174|Actinobacteria,4F5UV@85017|Promicromonosporaceae	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_6
k59_1695825_3	1713.JOFV01000012_gene732	1.31e-08	55.8	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,4F28U@85016|Cellulomonadaceae	201174|Actinobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	oppC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_755855_1	211114.JOEF01000003_gene2838	0.000288	41.6	COG0594@1|root,COG0594@2|Bacteria,2GR42@201174|Actinobacteria,4E5FQ@85010|Pseudonocardiales	201174|Actinobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	GO:0008150,GO:0040007	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
k59_755855_2	471853.Bcav_4223	9.03e-43	143.0	COG0759@1|root,COG0759@2|Bacteria,2GQZG@201174|Actinobacteria	201174|Actinobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
k59_1046424_2	1123073.KB899241_gene1880	2.01e-42	147.0	COG1595@1|root,COG1595@2|Bacteria,1N3BR@1224|Proteobacteria,1SCCR@1236|Gammaproteobacteria,1X4U8@135614|Xanthomonadales	135614|Xanthomonadales	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
k59_1461988_1	1163409.UUA_08029	1.28e-30	127.0	COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1X3AY@135614|Xanthomonadales	135614|Xanthomonadales	T	Chemotaxis protein histidine kinase and related kinases	pilL	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_1808149_1	758.BBIX01000006_gene230	4.39e-11	62.4	COG0274@1|root,COG0274@2|Bacteria,1N8AG@1224|Proteobacteria,1RPTS@1236|Gammaproteobacteria,1Y7EE@135625|Pasteurellales	135625|Pasteurellales	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
k59_1808149_2	1123393.KB891317_gene2207	1.14e-30	117.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,2VQ9J@28216|Betaproteobacteria,1KSDQ@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
k59_637747_1	1304865.JAGF01000001_gene1464	5.99e-88	268.0	COG4143@1|root,COG4143@2|Bacteria,2GMWD@201174|Actinobacteria,4F20D@85016|Cellulomonadaceae	201174|Actinobacteria	P	TIGRFAM ABC transporter, periplasmic binding protein, thiB subfamily	tbpA	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6
k59_1402212_1	637910.ROD_20901	1.75e-37	142.0	COG0318@1|root,COG0318@2|Bacteria,1PH7B@1224|Proteobacteria,1S1KM@1236|Gammaproteobacteria,3WZ5Z@544|Citrobacter	1236|Gammaproteobacteria	IQ	GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
k59_697776_1	713586.KB900536_gene1804	7.95e-58	200.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1WXM6@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_345916_1	1267533.KB906733_gene3362	1.12e-23	104.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
k59_1048354_1	935557.ATYB01000008_gene5385	1.13e-111	330.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,2U1SQ@28211|Alphaproteobacteria,4BAX2@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
k59_1161424_1	396588.Tgr7_1387	1.81e-29	118.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,1X0DP@135613|Chromatiales	135613|Chromatiales	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
k59_1161424_2	716541.ECL_02099	1.17e-12	66.2	2ANPA@1|root,31DNS@2|Bacteria,1RHTE@1224|Proteobacteria,1S78C@1236|Gammaproteobacteria,3WZYZ@547|Enterobacter	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3833)	PP2730	-	-	-	-	-	-	-	-	-	-	-	DUF3833
k59_637778_1	1175306.GWL_13730	1.07e-10	65.1	COG3073@1|root,COG3073@2|Bacteria,1N4G3@1224|Proteobacteria,2VUTB@28216|Betaproteobacteria,474QY@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	anti sigma-E protein RseA, N-terminal	rseA	-	-	ko:K03597	-	-	-	-	ko00000,ko03021	-	-	-	RseA_N
k59_1636812_1	1385935.N836_11090	6.05e-93	288.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1402260_1	1306174.JODP01000009_gene6573	1.5e-30	119.0	COG3200@1|root,COG3200@2|Bacteria,2GJBX@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the class-II DAHP synthase family	aroG	GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016043,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0022607,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901576	2.5.1.54	ko:K01626,ko:K16019	ko00400,ko01051,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01051,map01100,map01110,map01130,map01230,map02024	M00022	R01826,R06591	RC00435,RC01556	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2178c	DAHP_synth_2
k59_1402260_2	644284.Arch_0752	2.77e-14	72.4	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4D395@85005|Actinomycetales	201174|Actinobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.90	ko:K00895	ko00010,ko00030,ko00051,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map01100,map01110,map01120,map01130	-	R00764,R02073	RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_1578904_1	1267005.KB911258_gene615	9.98e-48	164.0	COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,2TRWC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the glutamate synthase family	glxD	-	2.1.1.21	ko:K22083	ko00680,ko01120,map00680,map01120	-	R01586	RC00554	ko00000,ko00001,ko01000	-	-	-	Glu_synthase
k59_1578904_2	314264.ROS217_18957	5.26e-22	94.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TTWE@28211|Alphaproteobacteria,46PPR@74030|Roseovarius	28211|Alphaproteobacteria	E	glutamine synthetase	glnT	-	6.3.1.2,6.3.4.12	ko:K01915,ko:K01949	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_1808209_1	1268237.G114_05085	1.94e-101	322.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1Y5D2@135624|Aeromonadales	135624|Aeromonadales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_1753578_1	396588.Tgr7_2744	9.19e-103	320.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales	135613|Chromatiales	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_757611_1	96561.Dole_3250	4.76e-66	217.0	COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,42S7X@68525|delta/epsilon subdivisions,2WNJ2@28221|Deltaproteobacteria,2MJG4@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_875677_1	292564.Cyagr_1119	1.66e-51	184.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1G1P1@1117|Cyanobacteria,22SJI@167375|Cyanobium	1117|Cyanobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_757633_1	1174504.AJTN02000035_gene3043	3.33e-34	131.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HC4S@91061|Bacilli,1ZQZX@1386|Bacillus	91061|Bacilli	C	acyl-CoA transferases carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_170639_1	697282.Mettu_0761	8.99e-66	225.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1XE41@135618|Methylococcales	135618|Methylococcales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0070569,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_1578948_1	1121271.AUCM01000002_gene4117	1.47e-34	122.0	COG0599@1|root,COG0599@2|Bacteria,1RD2R@1224|Proteobacteria,2U76K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	homolog of gamma-carboxymuconolactone decarboxylase subunit	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
k59_1578948_2	1208323.B30_04602	2.62e-27	105.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2TRB2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_170644_1	179408.Osc7112_2262	7.57e-15	79.3	COG2202@1|root,COG2203@1|root,COG3437@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,1G07W@1117|Cyanobacteria,1HA3J@1150|Oscillatoriales	1117|Cyanobacteria	T	SMART Signal transduction response regulator, receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k59_1048466_1	765912.Thimo_0089	1.05e-122	361.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1WWZW@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_1161493_1	400668.Mmwyl1_0924	6.07e-57	188.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria,1XI36@135619|Oceanospirillales	135619|Oceanospirillales	C	Belongs to the citrate synthase family	prpC	-	2.3.3.5	ko:K01659	ko00640,map00640	-	R00931	RC00004,RC00406,RC02827	ko00000,ko00001,ko01000	-	-	-	Citrate_synt
k59_1161493_2	236097.ADG881_1719	3.69e-14	72.4	COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,1RPQN@1236|Gammaproteobacteria,1XNCY@135619|Oceanospirillales	135619|Oceanospirillales	S	MmgE/PrpD family	-	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
k59_1578966_1	395495.Lcho_2693	1.24e-24	102.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,1KJ3N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Biotin carboxylase C-terminal domain	pccA	-	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_1578966_2	987059.RBXJA2T_09859	2.82e-61	201.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VIYF@28216|Betaproteobacteria,1KK87@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Carboxyl transferase domain	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_357201_1	1286106.MPL1_02218	1.03e-82	265.0	COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,1RSQ1@1236|Gammaproteobacteria,460MY@72273|Thiotrichales	72273|Thiotrichales	S	Zn-dependent protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_885546_2	471853.Bcav_2219	1.68e-50	168.0	COG0159@1|root,COG0159@2|Bacteria,2GN6T@201174|Actinobacteria	201174|Actinobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_179317_1	471853.Bcav_1907	2.81e-59	188.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria	201174|Actinobacteria	M	Oxidoreductase molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
k59_179317_2	479435.Kfla_2845	1.44e-35	140.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4DPC3@85009|Propionibacteriales	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_1529369_1	1121456.ATVA01000012_gene2731	3.23e-06	54.7	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,2M7SV@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM penicillin-binding protein transpeptidase	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
k59_1764171_1	1121035.AUCH01000015_gene2504	8.33e-18	87.0	COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,2VQGZ@28216|Betaproteobacteria,2KYI0@206389|Rhodocyclales	206389|Rhodocyclales	PT	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,cNMP_binding
k59_238444_1	1193181.BN10_300068	7.91e-103	307.0	COG0182@1|root,COG0182@2|Bacteria,2GJJA@201174|Actinobacteria,4FG3V@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
k59_414003_1	765911.Thivi_1799	5.92e-101	319.0	COG0204@1|root,COG0236@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0236@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria,1WWF0@135613|Chromatiales	135613|Chromatiales	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Acyltransferase,PP-binding
k59_1587962_1	1242864.D187_001179	2.52e-40	147.0	COG3503@1|root,COG3503@2|Bacteria,1QQ9D@1224|Proteobacteria	1224|Proteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
k59_591143_1	398767.Glov_3242	7.4e-16	79.3	COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,42PHS@68525|delta/epsilon subdivisions,2X5NU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	pqiB	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_1297672_1	1210908.HSB1_39710	1.93e-36	135.0	COG0385@1|root,arCOG02191@2157|Archaea,2XWY8@28890|Euryarchaeota,23WFA@183963|Halobacteria	183963|Halobacteria	S	Sodium Bile acid symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SBF
k59_358299_1	1121405.dsmv_0286	7.48e-23	95.9	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,42MG0@68525|delta/epsilon subdivisions,2WJE1@28221|Deltaproteobacteria,2MI2D@213118|Desulfobacterales	28221|Deltaproteobacteria	J	TIGRFAM histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_358299_2	237368.SCABRO_02407	3.29e-52	177.0	COG0269@1|root,COG0684@1|root,COG0269@2|Bacteria,COG0684@2|Bacteria,2J0G2@203682|Planctomycetes	203682|Planctomycetes	G	Orotidine 5'-phosphate decarboxylase / HUMPS family	-	-	4.1.2.43	ko:K08093	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338	RC00421,RC00422	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,RraA-like
k59_414658_1	1122933.JNIY01000010_gene1305	8.71e-87	274.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4F1TN@85016|Cellulomonadaceae	201174|Actinobacteria	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_825537_1	335543.Sfum_3479	1.3e-76	262.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2WIVR@28221|Deltaproteobacteria,2MQ8P@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_886617_1	1049564.TevJSym_ag00660	2.59e-61	217.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	PFAM von Willebrand factor type A	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	-
k59_1118879_1	204669.Acid345_4514	2.09e-26	109.0	COG2121@1|root,COG2121@2|Bacteria,3Y4VJ@57723|Acidobacteria,2JJE4@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF374)	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
k59_239209_1	713586.KB900536_gene1975	3.69e-108	313.0	COG0288@1|root,COG0288@2|Bacteria,1R3SC@1224|Proteobacteria,1RRB4@1236|Gammaproteobacteria,1WXB8@135613|Chromatiales	135613|Chromatiales	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
k59_1412916_1	652103.Rpdx1_2670	5.97e-71	227.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2TSFW@28211|Alphaproteobacteria,3JUBX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03072,ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_1706414_3	765910.MARPU_06045	9.64e-38	130.0	COG1380@1|root,COG1380@2|Bacteria,1N753@1224|Proteobacteria,1SDBW@1236|Gammaproteobacteria,1WYVC@135613|Chromatiales	135613|Chromatiales	S	PFAM LrgA	-	-	-	ko:K06518	-	-	-	-	ko00000,ko02000	1.E.14.2	-	-	LrgA
k59_1706414_4	693986.MOC_3896	3.92e-07	52.0	COG1346@1|root,COG1346@2|Bacteria,1MV81@1224|Proteobacteria,2TSP3@28211|Alphaproteobacteria,1JRVF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	PFAM LrgB family protein	lrgB	-	-	-	-	-	-	-	-	-	-	-	LrgB
k59_708474_2	1171373.PACID_02610	5.84e-29	106.0	COG2337@1|root,COG2337@2|Bacteria,2IR5D@201174|Actinobacteria,4DVPS@85009|Propionibacteriales	201174|Actinobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
k59_1354139_2	765913.ThidrDRAFT_4001	1.45e-30	110.0	2AN5S@1|root,31D3P@2|Bacteria,1QTIX@1224|Proteobacteria,1SW7H@1236|Gammaproteobacteria,1X1M7@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1354139_3	32057.KB217478_gene3262	1.35e-23	101.0	COG0176@1|root,COG0176@2|Bacteria,1G15G@1117|Cyanobacteria,1HIK3@1161|Nostocales	1117|Cyanobacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
k59_1471527_1	697282.Mettu_0416	1.59e-60	204.0	COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,1RPDG@1236|Gammaproteobacteria,1XE57@135618|Methylococcales	135618|Methylococcales	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_1530065_1	247634.GPB2148_801	4.3e-29	117.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1J52C@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation	deaD	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010501,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019439,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0032268,GO:0032270,GO:0033554,GO:0033592,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034655,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043170,GO:0043487,GO:0043488,GO:0043489,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045934,GO:0046483,GO:0046700,GO:0048255,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070035,GO:0070417,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097617,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902369,GO:1902373,GO:1903311,GO:1903312,GO:2000112	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DEADboxA,DbpA,Helicase_C
k59_1530065_2	558884.JRGM01000009_gene3355	3.12e-30	125.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1Y3V8@135624|Aeromonadales	135624|Aeromonadales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K11745,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37.1.1,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
k59_1297699_1	391625.PPSIR1_03323	1.87e-83	258.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,43AEV@68525|delta/epsilon subdivisions,2X5YA@28221|Deltaproteobacteria,2YUMQ@29|Myxococcales	28221|Deltaproteobacteria	S	Nitronate monooxygenase	-	-	1.13.12.16,1.3.1.9	ko:K00459,ko:K02371	ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212	M00083	R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076,RC02541,RC02759	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO
k59_1297699_2	527002.yaldo0001_21740	1.7e-57	190.0	COG0604@1|root,COG0604@2|Bacteria,1MU4N@1224|Proteobacteria,1RNSV@1236|Gammaproteobacteria,41E5E@629|Yersinia	1236|Gammaproteobacteria	C	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily	-	-	1.1.1.1,1.6.5.5	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
k59_1530070_1	497964.CfE428DRAFT_6434	1.69e-91	288.0	COG2943@1|root,COG2943@2|Bacteria,46S7P@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferase family group 2	mdoH	-	-	ko:K03669	-	-	-	-	ko00000,ko01000,ko01003,ko02000	4.D.3.1.1	GT2	-	Glyco_trans_2_3,Glycos_transf_2
k59_591163_2	387093.SUN_1729	4.03e-77	232.0	COG1943@1|root,COG1943@2|Bacteria,1RF1K@1224|Proteobacteria,42VRT@68525|delta/epsilon subdivisions,2YQZ0@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	L	COGs COG1943 Transposase and inactivated derivatives	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_1236865_1	1449063.JMLS01000004_gene2735	8.88e-28	125.0	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,4HAFP@91061|Bacilli,26SD1@186822|Paenibacillaceae	91061|Bacilli	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	acrB1	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_473571_1	1121946.AUAX01000024_gene7550	1.41e-09	64.3	COG1752@1|root,COG1752@2|Bacteria,2IB0F@201174|Actinobacteria,4DCP2@85008|Micromonosporales	201174|Actinobacteria	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_239226_2	71139.XP_010049700.1	2.45e-05	52.8	COG5078@1|root,KOG0417@2759|Eukaryota,37QGG@33090|Viridiplantae,3G8M8@35493|Streptophyta	35493|Streptophyta	O	Belongs to the ubiquitin-conjugating enzyme family	-	GO:0000209,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016567,GO:0016740,GO:0019538,GO:0019787,GO:0019899,GO:0031625,GO:0032446,GO:0033554,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044389,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0061630,GO:0061659,GO:0070647,GO:0071704,GO:0140096,GO:1901564	2.3.2.23	ko:K13960	ko03460,map03460	-	-	-	ko00000,ko00001,ko01000,ko03400,ko04121	-	-	-	UQ_con
k59_239226_4	34506.g2797	1e-10	63.2	COG0499@1|root,KOG1370@2759|Eukaryota,38CN8@33154|Opisthokonta,3BD4V@33208|Metazoa,3CREX@33213|Bilateria,40AM4@6231|Nematoda,1KTZV@119089|Chromadorea,40Z82@6236|Rhabditida	33208|Metazoa	H	S-adenosyl-L-homocysteine hydrolase, NAD binding domain	AHCY	GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0032259,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043621,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0046872,GO:0046914,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_358344_2	1123508.JH636448_gene7558	5.21e-08	55.1	COG1277@1|root,COG1277@2|Bacteria,2J0HW@203682|Planctomycetes	203682|Planctomycetes	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_1236866_1	1121405.dsmv_2489	7.43e-111	324.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,42NZV@68525|delta/epsilon subdivisions,2WKDG@28221|Deltaproteobacteria,2MIC6@213118|Desulfobacterales	28221|Deltaproteobacteria	P	TIGRFAM molybdate ABC transporter, inner membrane subunit	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
k59_825558_1	446466.Cfla_2578	4.98e-43	152.0	COG0282@1|root,COG0282@2|Bacteria,2GJAW@201174|Actinobacteria,4F11J@85016|Cellulomonadaceae	201174|Actinobacteria	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0409	Acetate_kinase
k59_945505_1	1454004.AW11_03037	8.43e-31	119.0	COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria	1224|Proteobacteria	P	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_5330_1	290340.AAur_3621	6.92e-69	217.0	2CHE3@1|root,31B2D@2|Bacteria,2IEQU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_64858_2	933115.GPDM_09190	2.83e-08	57.4	COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,4HAWB@91061|Bacilli,26EGC@186818|Planococcaceae	91061|Bacilli	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_1178051_1	1120960.ATXG01000001_gene735	2.18e-39	136.0	COG0035@1|root,COG0035@2|Bacteria,2GPJE@201174|Actinobacteria,4FKA4@85023|Microbacteriaceae	201174|Actinobacteria	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
k59_1471551_2	1123258.AQXZ01000018_gene1056	8.22e-35	127.0	2CK3K@1|root,32SBH@2|Bacteria,2IQJH@201174|Actinobacteria,4G23H@85025|Nocardiaceae	201174|Actinobacteria	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
k59_1471551_3	1223543.GP2_012_00730	6.84e-54	176.0	COG1051@1|root,COG1051@2|Bacteria,2IKKB@201174|Actinobacteria,4GDRU@85026|Gordoniaceae	201174|Actinobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_766655_1	1206735.BAGG01000066_gene2890	5.32e-130	388.0	COG5361@1|root,COG5361@2|Bacteria,2GRDZ@201174|Actinobacteria,4FWN7@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1471553_1	1118235.CAJH01000028_gene2004	6.97e-125	385.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1X45Q@135614|Xanthomonadales	135614|Xanthomonadales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_945516_1	1380394.JADL01000012_gene1024	3.56e-116	343.0	COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,2TRFI@28211|Alphaproteobacteria,2JPCP@204441|Rhodospirillales	204441|Rhodospirillales	Q	homogentisate 1,2-dioxygenase	-	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
k59_1647943_1	243365.CV_1456	1.4e-33	125.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2VHRF@28216|Betaproteobacteria,2KPFH@206351|Neisseriales	206351|Neisseriales	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_121465_1	96561.Dole_0079	9.22e-61	205.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,42P03@68525|delta/epsilon subdivisions,2WIPY@28221|Deltaproteobacteria,2MICJ@213118|Desulfobacterales	28221|Deltaproteobacteria	I	TIGRFAM methylmalonyl-CoA mutase, large subunit	-	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
k59_1236888_1	395493.BegalDRAFT_0286	8.13e-78	243.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,45ZMT@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_945520_1	1304865.JAGF01000001_gene1361	2.34e-78	246.0	COG0276@1|root,COG0276@2|Bacteria,2GJTQ@201174|Actinobacteria,4F12R@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
k59_649779_1	452637.Oter_0831	4.38e-59	206.0	COG2366@1|root,COG2366@2|Bacteria	2|Bacteria	D	antibiotic biosynthetic process	acyII	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_1588664_1	1304865.JAGF01000001_gene2720	9.33e-07	49.3	COG0055@1|root,COG0055@2|Bacteria,2GIY6@201174|Actinobacteria,4F0TY@85016|Cellulomonadaceae	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1588664_2	414996.IL38_20190	1.92e-14	70.5	COG0355@1|root,COG0355@2|Bacteria,2IHNZ@201174|Actinobacteria,4096A@622450|Actinopolysporales	201174|Actinobacteria	C	ATP synthase, Delta/Epsilon chain, beta-sandwich domain	atpC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
k59_1471559_1	1054213.HMPREF9946_03408	5.64e-34	138.0	COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,2TREX@28211|Alphaproteobacteria,2JX3R@204441|Rhodospirillales	204441|Rhodospirillales	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
k59_414710_1	367299.JOEE01000008_gene500	1.14e-123	369.0	COG1274@1|root,COG1274@2|Bacteria,2GJH3@201174|Actinobacteria,4FG28@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
k59_649780_1	585531.HMPREF0063_10383	7.29e-47	162.0	COG1305@1|root,COG1305@2|Bacteria,2GN5D@201174|Actinobacteria,4DQH4@85009|Propionibacteriales	201174|Actinobacteria	E	Bacterial transglutaminase-like N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_64878_1	446466.Cfla_1850	2.44e-99	292.0	COG0194@1|root,COG0194@2|Bacteria,2GK2M@201174|Actinobacteria,4F15J@85016|Cellulomonadaceae	201174|Actinobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
k59_64878_2	471853.Bcav_2043	7.08e-34	117.0	COG1758@1|root,COG1758@2|Bacteria,2IQHU@201174|Actinobacteria	201174|Actinobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
k59_1118915_1	1123024.AUII01000014_gene4289	8.69e-46	161.0	COG1690@1|root,COG1690@2|Bacteria,2GIUP@201174|Actinobacteria,4E0T7@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the RtcB family	rtcB	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_1297758_1	67267.JNXT01000054_gene2994	1.39e-22	104.0	COG3291@1|root,COG3291@2|Bacteria,2GJR2@201174|Actinobacteria	201174|Actinobacteria	S	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9
k59_1471569_1	335543.Sfum_1044	2.01e-79	255.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria,2MR0P@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA-2	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1471569_2	933262.AXAM01000038_gene910	4.28e-08	53.9	COG5401@1|root,COG5401@2|Bacteria,1NA0G@1224|Proteobacteria,42V1V@68525|delta/epsilon subdivisions,2WRCV@28221|Deltaproteobacteria,2MKUK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
k59_886706_1	349124.Hhal_1930	9.8e-33	121.0	290UJ@1|root,2ZNGJ@2|Bacteria,1RBSP@1224|Proteobacteria,1S3RZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1647963_1	936136.ARRT01000006_gene5495	0.000233	43.9	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,4B9AV@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1647963_2	522306.CAP2UW1_3650	5.98e-23	98.2	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2VPV5@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_649797_2	666685.R2APBS1_1810	5.4e-24	93.6	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,1S8XZ@1236|Gammaproteobacteria,1X78F@135614|Xanthomonadales	135614|Xanthomonadales	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_1297772_2	1027273.GZ77_05675	4.02e-54	182.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,1XH3A@135619|Oceanospirillales	135619|Oceanospirillales	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_5382_1	187272.Mlg_0529	6.05e-37	137.0	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	-	-	-	ko:K06191	-	-	-	-	ko00000	-	-	-	DUF3429,Glutaredoxin
k59_945552_1	1249627.D779_0556	4.2e-117	360.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WW6D@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_473619_1	1049564.TevJSym_aq00680	8.18e-61	193.0	COG4660@1|root,COG4660@2|Bacteria,1R342@1224|Proteobacteria,1T62W@1236|Gammaproteobacteria,1JBVX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Part of a membrane complex involved in electron transport	rnfE2	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
k59_473619_2	1049564.TevJSym_aq00690	3.08e-32	118.0	COG4659@1|root,COG4659@2|Bacteria,1REZV@1224|Proteobacteria,1T054@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Part of a membrane complex involved in electron transport	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
k59_708528_1	717785.HYPMC_1740	2.31e-101	317.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3N9EM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_185976_1	349741.Amuc_1642	7.76e-60	192.0	COG0623@1|root,COG0623@2|Bacteria,46ZBA@74201|Verrucomicrobia,2IW7X@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Enoyl-(Acyl carrier protein) reductase	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1068898_1	1424334.W822_03230	5.47e-14	75.1	COG3187@1|root,COG3187@2|Bacteria,1NGG1@1224|Proteobacteria,2WG9G@28216|Betaproteobacteria	28216|Betaproteobacteria	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
k59_953391_1	1203605.HMPREF1531_01494	1.35e-49	164.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_15980_1	1163408.UU9_03932	1.31e-159	461.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	ko:K12980	-	-	-	-	ko00000,ko01005	-	-	-	OMP_b-brl,Surface_Ag_2
k59_72661_1	1173024.KI912149_gene4979	4.91e-90	298.0	COG2319@1|root,COG2372@1|root,COG2319@2|Bacteria,COG2372@2|Bacteria	2|Bacteria	C	response to copper ion	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082,KAP_NTPase,SASA,SLH,WD40
k59_1244471_1	383372.Rcas_1934	3.99e-51	178.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2G7MP@200795|Chloroflexi,3760K@32061|Chloroflexia	32061|Chloroflexia	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	1.5.8.1,1.5.8.2	ko:K00317	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R01588,R02511	RC00185,RC00556,RC00557,RC00732	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
k59_953401_1	1049564.TevJSym_ab00620	1.17e-119	354.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNXA@1236|Gammaproteobacteria,1J5BC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Aminotransferase class I and II	IV02_28760	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_249601_1	1121019.AUMN01000014_gene4178	5.24e-83	279.0	COG1305@1|root,COG1305@2|Bacteria,2HQBB@201174|Actinobacteria,1WANJ@1268|Micrococcaceae	201174|Actinobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
k59_366176_1	572477.Alvin_0032	1.13e-14	72.8	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1WXP7@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_366176_2	1049564.TevJSym_bb00230	5.85e-177	539.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1J55M@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Glutamate synthase domain	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_16001_1	1268622.AVS7_00302	2.34e-10	67.0	COG2247@1|root,COG2374@1|root,COG3210@1|root,COG2247@2|Bacteria,COG2374@2|Bacteria,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	ko:K07004,ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	LTD,SLH
k59_1770023_2	1454010.JEOE01000031_gene3001	9.84e-48	157.0	COG0314@1|root,COG0314@2|Bacteria,2IQ9F@201174|Actinobacteria,4F2H3@85016|Cellulomonadaceae	201174|Actinobacteria	H	MoaE protein	moaE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
k59_1479516_1	1122933.JNIY01000003_gene142	1.13e-33	119.0	2E63U@1|root,330SV@2|Bacteria,2GSXM@201174|Actinobacteria,4F2VH@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_249619_1	396588.Tgr7_0980	2.51e-76	233.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,1WX98@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
k59_1653820_2	1713.JOFV01000001_gene1887	3.44e-19	81.3	COG2044@1|root,COG2044@2|Bacteria,2IHT6@201174|Actinobacteria,4F2HI@85016|Cellulomonadaceae	201174|Actinobacteria	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
k59_1419031_2	929558.SMGD1_0592	7.74e-18	84.3	COG3043@1|root,COG3043@2|Bacteria,1NAZB@1224|Proteobacteria,42SN1@68525|delta/epsilon subdivisions,2YPF9@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	Electron transfer subunit of the periplasmic nitrate reductase complex NapAB	napB	-	-	ko:K02568	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798	RC02812	ko00000,ko00001,ko00002	-	-	-	NapB
k59_1359514_1	305900.GV64_05460	6.77e-64	211.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,1RP02@1236|Gammaproteobacteria,1XH8F@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the degradation of histidine to urocanate and ammmonia	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
k59_771213_1	55207.KP22_06255	7.1e-31	128.0	COG0554@1|root,COG0554@2|Bacteria,1MXIZ@1224|Proteobacteria,1RNTK@1236|Gammaproteobacteria,1MRE4@122277|Pectobacterium	1236|Gammaproteobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	glpK_1	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_714292_1	583355.Caka_2045	6.59e-41	157.0	COG0771@1|root,COG2911@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	murD	-	3.4.21.10,6.3.2.13,6.3.2.9	ko:K01317,ko:K01925,ko:K01928,ko:K01932	ko00300,ko00471,ko00550,ko01100,map00300,map00471,map00550,map01100	-	R02783,R02788	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01002,ko01011,ko04131	-	-	-	DUF1727,Mur_ligase_C,Mur_ligase_M
k59_1593885_1	686340.Metal_1717	4.49e-78	241.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1XE2M@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_249633_1	1049564.TevJSym_ay00300	4.57e-63	196.0	COG4968@1|root,COG4968@2|Bacteria,1QW3U@1224|Proteobacteria,1T3FM@1236|Gammaproteobacteria,1JC2R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Type II secretion system (T2SS), protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
k59_249633_2	686340.Metal_3837	1.01e-74	239.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1XEBQ@135618|Methylococcales	135618|Methylococcales	U	type II secretion system	-	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
k59_1711609_1	472759.Nhal_3011	2.32e-55	199.0	COG0515@1|root,COG1262@1|root,COG3409@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,COG3409@2|Bacteria,1NQ5K@1224|Proteobacteria,1S2PN@1236|Gammaproteobacteria,1WYNY@135613|Chromatiales	135613|Chromatiales	KLT	PFAM Sulphatase-modifying factor	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA,PG_binding_1,Pkinase
k59_714296_1	768066.HELO_3806	3.78e-87	284.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1XHBY@135619|Oceanospirillales	135619|Oceanospirillales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_1535474_1	187272.Mlg_0157	7.05e-47	163.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WXWZ@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1535474_2	765910.MARPU_05390	2.78e-37	144.0	COG4191@1|root,COG4191@2|Bacteria,1MU55@1224|Proteobacteria,1RQ5N@1236|Gammaproteobacteria,1WWAJ@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c
k59_1712021_1	471853.Bcav_3037	1.03e-112	340.0	COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
k59_1184519_1	765912.Thimo_1081	3.55e-137	399.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1WWUV@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1184519_2	1049564.TevJSym_bg00190	8.1e-28	105.0	COG1057@1|root,COG1057@2|Bacteria	2|Bacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18,3.5.4.4,3.6.1.55	ko:K00969,ko:K01488,ko:K03574	ko00230,ko00760,ko01100,ko05340,map00230,map00760,map01100,map05340	M00115	R00137,R01560,R02556,R03005	RC00002,RC00477	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	iECUMN_1333.ECUMN_0733,iJN746.PP_4810,iPC815.YPO2607,iSbBS512_1146.SbBS512_E0612	CTP_transf_like
k59_954058_1	335543.Sfum_3313	5.5e-45	155.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,42PMQ@68525|delta/epsilon subdivisions,2WKB8@28221|Deltaproteobacteria,2MQEZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1245117_1	519989.ECTPHS_12398	6.61e-80	262.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1WVV0@135613|Chromatiales	135613|Chromatiales	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_1834438_1	925775.XVE_0232	8.51e-36	137.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1X3P0@135614|Xanthomonadales	135614|Xanthomonadales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_538372_1	593907.Celgi_1123	3.5e-63	201.0	COG0053@1|root,COG0053@2|Bacteria,2GKSG@201174|Actinobacteria	201174|Actinobacteria	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_538372_2	1437824.BN940_11506	4.96e-05	44.3	COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2VW58@28216|Betaproteobacteria,3T4SY@506|Alcaligenaceae	28216|Betaproteobacteria	S	Belongs to the UPF0434 family	ycaR	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
k59_1245128_1	1249627.D779_3441	3.98e-73	235.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1WWI2@135613|Chromatiales	135613|Chromatiales	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_1123939_1	1249627.D779_2225	1.7e-89	266.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,1RNMK@1236|Gammaproteobacteria,1WW8F@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_16874_1	1123367.C666_11510	2.77e-54	179.0	28I53@1|root,2Z88I@2|Bacteria,1NE5N@1224|Proteobacteria,2VZB8@28216|Betaproteobacteria,2KY3T@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF3750)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3750
k59_1535870_1	1120963.KB894492_gene1651	6.95e-47	155.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,1S3WJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Deacetylates O-acetyl-ADP ribose. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization activation	ymdB	GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0008150,GO:0008428,GO:0009892,GO:0010605,GO:0016787,GO:0019213,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0043086,GO:0043900,GO:0044092,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0061463,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:1900190,GO:1900231	-	-	-	-	-	-	-	-	-	-	Macro
k59_954087_1	931627.MycrhDRAFT_3605	1.8e-65	208.0	COG0682@1|root,COG0682@2|Bacteria,2GP8C@201174|Actinobacteria,235FI@1762|Mycobacteriaceae	201174|Actinobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	-	-	-	-	-	-	-	-	-	-	-	-	LGT
k59_596798_1	471853.Bcav_1999	5.43e-154	456.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria	201174|Actinobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_250527_1	258052.JNYV01000012_gene3818	6.33e-23	107.0	COG0739@1|root,COG0741@1|root,COG0739@2|Bacteria,COG0741@2|Bacteria,2I54D@201174|Actinobacteria,2M67Q@2063|Kitasatospora	201174|Actinobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23,SLT,SLT_2,Transglycosylas
k59_1184550_1	1121918.ARWE01000001_gene3563	3.2e-60	196.0	COG0583@1|root,COG0583@2|Bacteria,1PX1B@1224|Proteobacteria,43AY5@68525|delta/epsilon subdivisions,2X6CI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_895116_1	1108045.GORHZ_118_00070	1.04e-52	175.0	COG1148@1|root,COG1148@2|Bacteria,2IQQS@201174|Actinobacteria	201174|Actinobacteria	C	FAD binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2
k59_127795_1	526218.Sterm_0782	3.4e-37	135.0	COG3369@1|root,COG3592@1|root,COG3369@2|Bacteria,COG3592@2|Bacteria,3787U@32066|Fusobacteria	32066|Fusobacteria	S	CDGSH-type zinc finger. Function unknown.	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_19,zf-CDGSH
k59_16918_1	1035308.AQYY01000001_gene3468	0.000208	44.7	COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia,260NB@186807|Peptococcaceae	186801|Clostridia	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9,2.7.9.2	ko:K01007,ko:K08483	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_16918_2	1035308.AQYY01000001_gene3469	5.04e-46	149.0	COG1925@1|root,COG1925@2|Bacteria,1VA0R@1239|Firmicutes,24QIP@186801|Clostridia,2634E@186807|Peptococcaceae	186801|Clostridia	G	TIGRFAM Phosphotransferase System	-	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
k59_1419537_1	56107.Cylst_4431	9.3e-16	80.5	COG1574@1|root,COG1574@2|Bacteria,1G40U@1117|Cyanobacteria,1HSYE@1161|Nostocales	1117|Cyanobacteria	S	TIM-barrel fold metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_895121_2	1232683.ADIMK_4155	3.44e-50	181.0	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,1RMMF@1236|Gammaproteobacteria,4652R@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	ytfN	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0097347	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
k59_1770492_1	1469607.KK073769_gene5550	1.02e-67	231.0	COG2202@1|root,COG3852@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3852@2|Bacteria,COG5001@2|Bacteria,1G0BS@1117|Cyanobacteria,1HTQ5@1161|Nostocales	1117|Cyanobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_1770493_1	2340.JV46_18600	4.11e-132	379.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,1RPJQ@1236|Gammaproteobacteria,1J5IF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	-	ko:K01663,ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	iECO111_1330.ECO111_2749,iEcolC_1368.EcolC_1617,iYL1228.KPN_02481	His_biosynth
k59_1654353_1	1117647.M5M_06810	4.36e-34	132.0	COG3291@1|root,COG3291@2|Bacteria,1QU15@1224|Proteobacteria,1T1KN@1236|Gammaproteobacteria,1J4QR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1480228_1	1121943.KB899994_gene988	7.66e-57	185.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,1XJCZ@135619|Oceanospirillales	135619|Oceanospirillales	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
k59_1535892_1	1049564.TevJSym_as00600	2.97e-83	259.0	COG4360@1|root,COG4360@2|Bacteria,1RB5I@1224|Proteobacteria,1SN5G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	ATP adenylyltransferase (5',5''-P-1,P-4-tetraphosphate phosphorylase II)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_420770_1	396588.Tgr7_1387	7.09e-52	180.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,1X0DP@135613|Chromatiales	135613|Chromatiales	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
k59_954124_1	1267005.KB911256_gene2052	2.27e-125	371.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TRFY@28211|Alphaproteobacteria,3N67X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_250577_1	1121272.KB903249_gene2392	2.65e-58	197.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4DBPC@85008|Micromonosporales	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
k59_1419557_1	631362.Thi970DRAFT_01739	1.32e-14	75.5	COG3900@1|root,COG3900@2|Bacteria,1NXBA@1224|Proteobacteria,1SZCY@1236|Gammaproteobacteria,1X2JW@135613|Chromatiales	135613|Chromatiales	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
k59_1834508_1	243090.RB7058	2.56e-51	184.0	COG0515@1|root,COG0515@2|Bacteria,2J50A@203682|Planctomycetes	203682|Planctomycetes	KLT	PFAM Serine threonine protein kinase-related	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,dCache_1
k59_250581_1	301.JNHE01000001_gene522	5e-75	242.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1YFCW@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1069660_1	1519464.HY22_10555	5.24e-58	188.0	COG1136@1|root,COG1136@2|Bacteria	2|Bacteria	V	lipoprotein transporter activity	lolD	-	-	ko:K02003,ko:K09810	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.125	-	-	ABC_tran
k59_186542_1	1487923.DP73_20250	3.81e-65	214.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,2613E@186807|Peptococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_186542_2	240016.ABIZ01000001_gene14	3.48e-109	331.0	COG0064@1|root,COG0064@2|Bacteria,46S5X@74201|Verrucomicrobia,2ITJA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_831953_1	382464.ABSI01000007_gene4146	3.9e-66	216.0	COG1139@1|root,COG1139@2|Bacteria,46SBN@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Domain of unknown function (DUF3390)	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
k59_538438_2	543734.LCABL_27590	2.38e-26	109.0	COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,4HA4R@91061|Bacilli,3F3VC@33958|Lactobacillaceae	91061|Bacilli	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_771620_1	555778.Hneap_0782	1.17e-55	187.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1WX2Q@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3,HlyD_D23,OEP
k59_17005_1	706587.Desti_2519	9.02e-102	310.0	COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,42M2C@68525|delta/epsilon subdivisions,2WIVE@28221|Deltaproteobacteria,2MQT5@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
k59_73425_1	1134474.O59_003747	1.18e-09	65.5	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,1FFW1@10|Cellvibrio	1236|Gammaproteobacteria	S	L,D-transpeptidase catalytic domain	ycbB	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_1535921_2	1121405.dsmv_3603	1.51e-95	285.0	COG2227@1|root,COG2227@2|Bacteria,1QZT3@1224|Proteobacteria,42QXG@68525|delta/epsilon subdivisions,2WMWI@28221|Deltaproteobacteria,2MJJJ@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
k59_1770529_1	582899.Hden_0696	7.33e-58	182.0	COG0509@1|root,COG0509@2|Bacteria,1RKRS@1224|Proteobacteria,2UAPN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glycine cleavage H-protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
k59_1425606_1	1049564.TevJSym_ai00210	1.13e-119	360.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1J4VX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_485468_1	1123371.ATXH01000006_gene895	3.05e-96	299.0	COG0445@1|root,COG0445@2|Bacteria,2GHNC@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_25400_1	2340.JV46_12120	1.36e-73	234.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1J4E0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_25400_2	765912.Thimo_0669	4.52e-11	62.8	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,1WW3U@135613|Chromatiales	135613|Chromatiales	T	PFAM PhoH family protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_1842815_1	290397.Adeh_3163	6.53e-49	182.0	2F2IM@1|root,33VFK@2|Bacteria,1RIX8@1224|Proteobacteria,42T5Z@68525|delta/epsilon subdivisions,2WPA9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
k59_1842819_1	396588.Tgr7_0028	1.75e-24	103.0	COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria,1WWAM@135613|Chromatiales	135613|Chromatiales	H	Uroporphyrinogen III synthase	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
k59_1253127_1	1278309.KB907111_gene3394	8.86e-114	346.0	COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria,1S01Y@1236|Gammaproteobacteria,1XIYH@135619|Oceanospirillales	135619|Oceanospirillales	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4
k59_1776407_1	1454004.AW11_00972	2.19e-67	233.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,1KQ8R@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1776407_2	1205680.CAKO01000002_gene2180	6.98e-34	123.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,2TS0J@28211|Alphaproteobacteria,2JPTC@204441|Rhodospirillales	204441|Rhodospirillales	Q	ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1314637_1	526225.Gobs_2302	6.42e-57	193.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4ERW2@85013|Frankiales	201174|Actinobacteria	G	SMART alpha amylase, catalytic sub domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_1776409_1	502025.Hoch_1527	2.95e-07	57.8	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF4384,PEGA,Pkinase,TPR_12
k59_1717937_1	296591.Bpro_4806	3.42e-33	123.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VNSH@28216|Betaproteobacteria,4AJ48@80864|Comamonadaceae	28216|Betaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_1717937_2	948106.AWZT01000098_gene2282	7.91e-08	53.9	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2VJ2W@28216|Betaproteobacteria,1K2WR@119060|Burkholderiaceae	28216|Betaproteobacteria	S	transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_25423_1	1082933.MEA186_30901	2e-42	158.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_309405_1	649831.L083_0606	2.06e-86	272.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4D93A@85008|Micromonosporales	201174|Actinobacteria	P	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
k59_1253147_1	472759.Nhal_0546	1e-41	157.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1WXQJ@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_259253_1	42565.FP66_06775	4.92e-78	241.0	COG0189@1|root,COG0189@2|Bacteria,1PJQE@1224|Proteobacteria,1RZ2S@1236|Gammaproteobacteria,1XNVV@135619|Oceanospirillales	135619|Oceanospirillales	HJ	Prokaryotic glutathione synthetase, ATP-grasp domain	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
k59_962495_1	156889.Mmc1_3385	1.5e-68	232.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_1129241_1	998674.ATTE01000001_gene369	3.51e-89	277.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,4605B@72273|Thiotrichales	72273|Thiotrichales	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
k59_1129241_2	1082931.KKY_639	5.8e-22	89.0	COG2983@1|root,COG2983@2|Bacteria,1RHMX@1224|Proteobacteria,2U99S@28211|Alphaproteobacteria,3N6XD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0260 family	MA20_15575	-	-	ko:K09160	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_1842854_1	448385.sce4900	3.34e-103	308.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,42MY6@68525|delta/epsilon subdivisions,2WMDC@28221|Deltaproteobacteria,2YU5V@29|Myxococcales	28221|Deltaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1488090_1	634956.Geoth_0441	1.43e-08	63.9	COG2390@1|root,COG2390@2|Bacteria,1TP62@1239|Firmicutes,4HAE6@91061|Bacilli,1WE56@129337|Geobacillus	91061|Bacilli	K	Putative sugar-binding domain	cggR	-	-	ko:K05311	-	-	-	-	ko00000,ko03000	-	-	-	Sugar-bind
k59_1488090_2	1121380.JNIW01000001_gene2753	3.99e-25	110.0	COG2390@1|root,COG2390@2|Bacteria,1WMUX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Putative sugar-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sugar-bind
k59_1488090_3	397278.JOJN01000001_gene2637	0.000547	42.7	COG2213@1|root,COG4668@1|root,COG2213@2|Bacteria,COG4668@2|Bacteria,2GMYR@201174|Actinobacteria,4DPTM@85009|Propionibacteriales	201174|Actinobacteria	G	Phosphotransferase system, EIIC	mtlA	-	2.7.1.197	ko:K02798,ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	M00274	R02704	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5	-	-	PTS_EIIA_2,PTS_EIIC,PTS_IIB
k59_81717_1	396588.Tgr7_1089	7.61e-104	318.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1WW67@135613|Chromatiales	135613|Chromatiales	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_1542036_1	1267005.KB911259_gene3748	1.6e-68	213.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2TQJ9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	ycbL	GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_25454_1	643562.Daes_3225	4.39e-10	63.5	COG2208@1|root,COG3829@1|root,COG5002@1|root,COG2208@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	PAS
k59_1011437_1	382464.ABSI01000023_gene608	8.23e-15	70.1	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
k59_1011437_2	1254432.SCE1572_36840	3.73e-31	119.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,42PEC@68525|delta/epsilon subdivisions,2X5JG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1129248_1	535289.Dtpsy_1496	6.27e-72	231.0	COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,2VHRI@28216|Betaproteobacteria,4AC10@80864|Comamonadaceae	28216|Betaproteobacteria	V	PFAM ABC-2 type transporter	yhhJ	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_259281_1	1026882.MAMP_01036	1.49e-94	299.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,45ZWJ@72273|Thiotrichales	72273|Thiotrichales	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
k59_1366107_1	1380354.JIAN01000005_gene1353	2.74e-05	47.4	2E6UC@1|root,331E3@2|Bacteria,2GXPQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1366107_2	1454010.JEOE01000012_gene1607	1.03e-38	152.0	COG2311@1|root,COG2311@2|Bacteria,2GKA8@201174|Actinobacteria,4F17I@85016|Cellulomonadaceae	201174|Actinobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1366107_3	996637.SGM_3065	8.46e-95	284.0	COG0074@1|root,COG0074@2|Bacteria,2GK00@201174|Actinobacteria	201174|Actinobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_1717971_1	1439940.BAY1663_04909	5.93e-15	74.3	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S8RS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	biopolymer transport protein	tolR	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032153,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
k59_1717971_2	1163617.SCD_n02541	1.64e-70	218.0	COG0811@1|root,COG0811@2|Bacteria,1NMPB@1224|Proteobacteria,2VJ4U@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Mota tolq exbb proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_375304_1	1211844.CBLM010000124_gene1601	6.25e-53	180.0	COG0034@1|root,COG0034@2|Bacteria,1TPH3@1239|Firmicutes,3VNS3@526524|Erysipelotrichia	526524|Erysipelotrichia	F	Glutamine amidotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	GATase_7
k59_1011442_1	323261.Noc_0612	8.58e-09	58.2	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1WWPS@135613|Chromatiales	135613|Chromatiales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_1011442_2	697281.Mahau_1387	4.36e-13	70.9	COG2021@1|root,COG2021@2|Bacteria,1TQSV@1239|Firmicutes,249GY@186801|Clostridia,42FGI@68295|Thermoanaerobacterales	186801|Clostridia	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_1190689_1	644107.SL1157_A0196	5.86e-72	229.0	COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,2TVCB@28211|Alphaproteobacteria,4NA2P@97050|Ruegeria	28211|Alphaproteobacteria	S	Cytochrome D1 heme domain	nirF	-	-	ko:K19345	-	-	-	-	ko00000	-	-	-	Cytochrom_D1
k59_81747_1	519989.ECTPHS_07331	1.85e-74	248.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales	135613|Chromatiales	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1079093_1	396588.Tgr7_2900	2.38e-52	189.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_1842896_1	394221.Mmar10_1457	2.95e-11	68.2	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,2TWZ1@28211|Alphaproteobacteria,44159@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Trans_reg_C
k59_1314717_1	631362.Thi970DRAFT_03286	1.22e-58	195.0	COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,1WWEB@135613|Chromatiales	135613|Chromatiales	D	Part of the ABC transporter FtsEX involved in cellular division	-	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
k59_375317_1	1094715.CM001373_gene671	5.67e-179	526.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1JCU0@118969|Legionellales	118969|Legionellales	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1079105_1	314285.KT71_15299	1.72e-31	110.0	COG0333@1|root,COG0333@2|Bacteria,1N6RF@1224|Proteobacteria,1SC9G@1236|Gammaproteobacteria,1J6TX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
k59_1079105_2	247634.GPB2148_75	5.13e-10	58.5	COG1399@1|root,COG1399@2|Bacteria,1PGKW@1224|Proteobacteria,1RRK3@1236|Gammaproteobacteria,1J6U0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	metal-binding, possibly nucleic acid-binding protein	yceD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
k59_1190698_2	330214.NIDE1147	3.2e-56	183.0	292MF@1|root,2ZQ5C@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3047)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3047
k59_485537_1	1218076.BAYB01000018_gene3470	1.41e-19	86.7	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,2VKKQ@28216|Betaproteobacteria,1K25A@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_837969_2	1211777.BN77_2526	1.66e-195	565.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,4B9AV@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_544235_1	1231190.NA8A_03535	3e-23	101.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,43HNC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	heavy metal translocating P-type ATPase	actP	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
k59_1425686_2	1267005.KB911256_gene1465	7.38e-128	374.0	COG0604@1|root,COG0604@2|Bacteria,1MXIK@1224|Proteobacteria,2TQPR@28211|Alphaproteobacteria,3N7S6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	reductase	ccrA	-	1.1.1.1,1.3.1.85	ko:K00001,ko:K14446	ko00010,ko00071,ko00350,ko00625,ko00626,ko00630,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00010,map00071,map00350,map00625,map00626,map00630,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220	M00373	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R09291	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273,RC02481	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1314737_1	795359.TOPB45_0685	3.38e-58	201.0	COG1674@1|root,COG1674@2|Bacteria,2GHMR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1776473_1	367299.JOEE01000001_gene1472	3.1e-105	317.0	COG1066@1|root,COG1066@2|Bacteria,2GMQ0@201174|Actinobacteria,4FF4M@85021|Intrasporangiaceae	201174|Actinobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
k59_1600380_1	68223.JNZY01000010_gene1898	6.48e-95	295.0	COG0477@1|root,COG0477@2|Bacteria,2GITS@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_426792_1	477228.YO5_14765	1.67e-74	233.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1Z0Y4@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iSSON_1240.SSON_3886,iYL1228.KPN_04138	ATP-synt
k59_426792_2	1211114.ALIP01000091_gene2853	5.87e-76	243.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1X31U@135614|Xanthomonadales	135614|Xanthomonadales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_81781_1	671143.DAMO_2551	1.14e-86	264.0	COG1250@1|root,COG1250@2|Bacteria,2NP11@2323|unclassified Bacteria	2|Bacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_81781_2	1122212.AULO01000006_gene1878	1.99e-09	55.5	COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,1S8QZ@1236|Gammaproteobacteria,1XKFG@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
k59_26356_1	1035308.AQYY01000001_gene2926	1.91e-73	240.0	COG1506@1|root,COG1506@2|Bacteria,1TQ85@1239|Firmicutes,25B1P@186801|Clostridia	186801|Clostridia	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_26356_2	1219581.HMPREF1628_02585	1.1e-20	90.1	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4D39V@85005|Actinomycetales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1843771_1	1123518.ARWI01000001_gene665	3.24e-61	204.0	COG1249@1|root,COG1249@2|Bacteria,1MXQ3@1224|Proteobacteria,1RQ44@1236|Gammaproteobacteria,460A7@72273|Thiotrichales	72273|Thiotrichales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1542649_1	953739.SVEN_2053	2.36e-39	147.0	COG0477@1|root,COG1846@1|root,COG0477@2|Bacteria,COG1846@2|Bacteria,2GJ09@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_904428_1	498761.HM1_2430	2.6e-32	133.0	COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia	186801|Clostridia	KLT	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_260254_1	573065.Astex_3285	2.27e-36	140.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,2KG0Z@204458|Caulobacterales	204458|Caulobacterales	C	aldehyde oxidase and xanthine dehydrogenase molybdopterin binding	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_1426297_1	1500893.JQNB01000001_gene2273	5.34e-46	150.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,1S8XZ@1236|Gammaproteobacteria,1X78F@135614|Xanthomonadales	135614|Xanthomonadales	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_776988_1	1173020.Cha6605_1285	9.79e-14	76.3	COG3547@1|root,COG3547@2|Bacteria,1G077@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_310041_2	1469245.JFBG01000027_gene1458	6.63e-25	100.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1WYNT@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
k59_82628_1	1207063.P24_15539	1.98e-37	141.0	COG0589@1|root,COG0589@2|Bacteria,1RATR@1224|Proteobacteria,2U6UI@28211|Alphaproteobacteria,2JZR5@204441|Rhodospirillales	204441|Rhodospirillales	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1315609_1	593907.Celgi_0776	1.04e-60	201.0	COG1609@1|root,COG1609@2|Bacteria,2GJV7@201174|Actinobacteria,4F1WK@85016|Cellulomonadaceae	201174|Actinobacteria	K	periplasmic binding protein LacI transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
k59_427366_1	626939.HMPREF9443_01094	8.47e-59	200.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,4H2D7@909932|Negativicutes	909932|Negativicutes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_1191306_1	649638.Trad_2085	2.16e-93	281.0	COG0320@1|root,COG0320@2|Bacteria,1WIE7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_1366739_1	349521.HCH_06357	1.09e-14	71.2	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,1S9AB@1236|Gammaproteobacteria,1XMH4@135619|Oceanospirillales	135619|Oceanospirillales	S	DUF167	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
k59_1366739_2	717231.Flexsi_0297	1.87e-20	82.0	2ES2C@1|root,33JMA@2|Bacteria,2GG4K@200930|Deferribacteres	200930|Deferribacteres	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1254046_1	1454004.AW11_02488	3.23e-71	228.0	COG0394@1|root,COG0704@1|root,COG0394@2|Bacteria,COG0704@2|Bacteria	2|Bacteria	P	negative regulation of phosphate transmembrane transport	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	1.20.4.1,3.1.3.48	ko:K01104,ko:K02039,ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	PhoU
k59_486141_1	545264.KB898745_gene1111	1.74e-39	146.0	COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,1RMSM@1236|Gammaproteobacteria,1WVWU@135613|Chromatiales	135613|Chromatiales	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
k59_486141_2	765914.ThisiDRAFT_0149	1.09e-89	284.0	COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,1RMSM@1236|Gammaproteobacteria,1WVWU@135613|Chromatiales	135613|Chromatiales	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
k59_544797_1	1121904.ARBP01000013_gene386	4.48e-95	290.0	COG0673@1|root,COG0673@2|Bacteria,4NF4Q@976|Bacteroidetes,47M9C@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_1315627_1	1246448.ANAZ01000002_gene3814	3.36e-78	236.0	COG1670@1|root,COG1670@2|Bacteria,2H4AD@201174|Actinobacteria,4EJIU@85012|Streptosporangiales	201174|Actinobacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1542678_1	105559.Nwat_1218	3.34e-60	196.0	COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria,1WVWS@135613|Chromatiales	135613|Chromatiales	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	apaH	-	3.6.1.41	ko:K01525	ko00230,map00230	-	R00125	RC00002	ko00000,ko00001,ko01000	-	-	-	Metallophos
k59_1254056_1	713587.THITH_14760	6.24e-55	172.0	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,1WYMA@135613|Chromatiales	135613|Chromatiales	O	Belongs to the glutaredoxin family. Monothiol subfamily	-	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
k59_1254056_2	765910.MARPU_14675	5.86e-56	189.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1WWE5@135613|Chromatiales	135613|Chromatiales	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_1431645_1	1120951.AUBG01000012_gene1544	1.62e-39	149.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1HZQR@117743|Flavobacteriia	976|Bacteroidetes	K	COGs COG5616 integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,HTH_18,TPR_8
k59_432511_1	1454010.JEOE01000013_gene2221	4.55e-45	155.0	COG0431@1|root,COG0431@2|Bacteria,2IHWU@201174|Actinobacteria,4F27D@85016|Cellulomonadaceae	201174|Actinobacteria	S	NADPH-dependent FMN reductase	ssuE	-	1.5.1.38	ko:K00299	ko00740,ko00920,ko01100,map00740,map00920,map01100	-	R05706,R07210,R10206	RC00126,RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	FMN_red
k59_491345_1	298653.Franean1_5773	7.64e-49	173.0	COG1321@1|root,COG1321@2|Bacteria,2GN2R@201174|Actinobacteria	201174|Actinobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1605817_1	671143.DAMO_3069	3.98e-74	235.0	COG0156@1|root,COG0156@2|Bacteria,2NNMX@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.29,2.3.1.47,2.3.1.50	ko:K00639,ko:K00652,ko:K00654	ko00260,ko00600,ko00780,ko01100,ko04071,ko04138,map00260,map00600,map00780,map01100,map04071,map04138	M00094,M00099,M00123,M00573,M00577	R00371,R01281,R03210,R10124	RC00004,RC00039,RC00394,RC02725,RC02849	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_726344_1	697282.Mettu_2060	6.83e-94	306.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,1XEJM@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0753 family	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k59_912036_1	472759.Nhal_2480	4.93e-101	306.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,1WXJN@135613|Chromatiales	135613|Chromatiales	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1782164_1	1235803.C825_02181	5.06e-47	167.0	COG0606@1|root,COG0606@2|Bacteria,4NE0G@976|Bacteroidetes,2FMHE@200643|Bacteroidia,22W0Y@171551|Porphyromonadaceae	976|Bacteroidetes	O	magnesium chelatase	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_139646_1	765913.ThidrDRAFT_2023	3.31e-19	81.6	COG0316@1|root,COG0316@2|Bacteria,1RKPC@1224|Proteobacteria,1SB76@1236|Gammaproteobacteria,1WYKT@135613|Chromatiales	135613|Chromatiales	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
k59_139646_2	1049564.TevJSym_aw00080	8.2e-49	170.0	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,1RR1J@1236|Gammaproteobacteria,1JBRK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	CobB/CobQ-like glutamine amidotransferase domain	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,CbiA,GATase_3
k59_667891_1	1223523.H340_09266	3.38e-34	125.0	COG2197@1|root,COG2197@2|Bacteria,2GIXB@201174|Actinobacteria	201174|Actinobacteria	T	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_667891_2	1169161.KB897721_gene4124	3.85e-15	79.7	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_383769_1	335543.Sfum_0676	2.29e-133	392.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2WIN7@28221|Deltaproteobacteria,2MQWN@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Biotin carboxylase C-terminal domain	accC	-	6.3.4.14,6.4.1.1,6.4.1.2	ko:K01959,ko:K01961	ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230	M00082,M00173,M00376,M00620	R00344,R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_35547_1	1087481.AGFX01000018_gene1664	2.02e-23	102.0	COG0535@1|root,COG0535@2|Bacteria,1TXJ2@1239|Firmicutes,4I6IM@91061|Bacilli,26T8D@186822|Paenibacillaceae	91061|Bacilli	S	Fe-S oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
k59_140141_1	857087.Metme_0574	3.19e-76	246.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1XEBM@135618|Methylococcales	135618|Methylococcales	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
k59_726858_1	246969.TAM4_1517	9.25e-19	88.6	COG0582@1|root,arCOG01241@2157|Archaea,2XV3E@28890|Euryarchaeota,242ZK@183968|Thermococci	183968|Thermococci	J	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	xerA	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
k59_91255_1	379731.PST_1966	5.42e-25	102.0	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,1RNMF@1236|Gammaproteobacteria,1YZZC@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1722)	ybgA	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
k59_91255_2	1384054.N790_04825	5.83e-25	98.2	COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,1S425@1236|Gammaproteobacteria,1XCMA@135614|Xanthomonadales	135614|Xanthomonadales	O	Belongs to the glutathione peroxidase family	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
k59_384766_2	1121406.JAEX01000005_gene3046	6.31e-23	96.3	COG1834@1|root,COG1834@2|Bacteria,1MZ9U@1224|Proteobacteria,42PPN@68525|delta/epsilon subdivisions,2WK8S@28221|Deltaproteobacteria,2M7WI@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM amidinotransferase	-	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
k59_726865_1	1220583.GOACH_15_01000	3.63e-168	483.0	COG3344@1|root,COG3344@2|Bacteria,2GUJS@201174|Actinobacteria,4GD7Y@85026|Gordoniaceae	201174|Actinobacteria	L	Group II intron, maturase-specific domain	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_1782644_1	247639.MGP2080_05892	2.02e-91	277.0	COG1834@1|root,COG1834@2|Bacteria,1PGHK@1224|Proteobacteria,1S0J3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	amidinotransferase	-	-	2.1.4.1	ko:K00613	ko00260,ko00330,ko01100,map00260,map00330,map01100	M00047	R00565,R01989	RC00024,RC02749	ko00000,ko00001,ko00002,ko01000	-	-	-	-
k59_384773_1	105425.BBPL01000038_gene2900	6.83e-17	79.3	2EP16@1|root,33GN1@2|Bacteria,2IHWQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_384773_2	136273.GY22_15345	1.34e-14	72.0	2BX7X@1|root,32RMD@2|Bacteria,2IKN7@201174|Actinobacteria,1W9J9@1268|Micrococcaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_198743_1	1121406.JAEX01000005_gene2868	4.08e-67	218.0	COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,42NI3@68525|delta/epsilon subdivisions,2WJ6P@28221|Deltaproteobacteria,2M856@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_384780_1	471853.Bcav_0702	1.66e-133	397.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria	201174|Actinobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_316093_1	105559.Nwat_0227	2.83e-53	179.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1WWB9@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_1087272_1	713586.KB900536_gene1203	2.88e-56	195.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1WWDE@135613|Chromatiales	135613|Chromatiales	T	Belongs to the PEP-utilizing enzyme family	-	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_1782651_1	391615.ABSJ01000042_gene2203	9.91e-77	244.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1J50Z@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	lpdG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iE2348C_1286.E2348C_4372,iJN746.PP_4187	Pyr_redox_2,Pyr_redox_dim
k59_972116_1	1463881.KL591017_gene3227	9.39e-41	146.0	COG1125@1|root,COG1125@2|Bacteria,2GJHI@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	opuCA	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran
k59_1782652_1	443152.MDG893_13304	9.53e-59	203.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,464IT@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Belongs to the PEP-utilizing enzyme family	ptsP	GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008965,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0016775,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:1901564,GO:1901698	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_36337_1	768704.Desmer_4321	9.41e-50	176.0	COG3666@1|root,COG3666@2|Bacteria,1TQQ9@1239|Firmicutes,24AG9@186801|Clostridia,26246@186807|Peptococcaceae	186801|Clostridia	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_433103_1	870187.Thini_1202	2.32e-23	99.0	COG1295@1|root,COG1295@2|Bacteria,1NH82@1224|Proteobacteria,1S3T8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ribonuclease BN	-	-	-	-	-	-	-	-	-	-	-	-	Virul_fac_BrkB
k59_913087_1	1089547.KB913013_gene1769	6.28e-52	186.0	COG3940@1|root,COG3940@2|Bacteria,4PKWP@976|Bacteroidetes,47MYK@768503|Cytophagia	976|Bacteroidetes	G	alpha-L-rhamnosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106,Glyco_hydro_2_N,Glyco_hydro_43,Laminin_G_3
k59_269875_1	1121106.JQKB01000014_gene5623	0.00044	43.1	COG1522@1|root,COG1522@2|Bacteria,1N0DP@1224|Proteobacteria,2UC1F@28211|Alphaproteobacteria,2JTAZ@204441|Rhodospirillales	204441|Rhodospirillales	K	helix_turn_helix ASNC type	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_AsnC-type
k59_269875_2	1451261.AS96_10660	3.03e-32	123.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,4FMTB@85023|Microbacteriaceae	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.48,4.4.1.11	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1432237_1	1121937.AUHJ01000001_gene810	9.88e-73	231.0	2DBBP@1|root,2Z88Z@2|Bacteria,1R3B4@1224|Proteobacteria,1RSHG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
k59_36344_1	1151126.AQYI01000006_gene3105	2.54e-14	72.0	COG1251@1|root,COG1251@2|Bacteria,2GJ3U@201174|Actinobacteria,4FM2V@85023|Microbacteriaceae	201174|Actinobacteria	C	Nitrite and sulphite reductase 4Fe-4S domain	nirB	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
k59_36344_2	935839.JAGJ01000004_gene1926	4.97e-45	152.0	COG2146@1|root,COG2146@2|Bacteria,2IQM4@201174|Actinobacteria,4F4V4@85017|Promicromonosporaceae	201174|Actinobacteria	P	Rieske-like [2Fe-2S] domain	nirD	-	1.7.1.15	ko:K00363	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske_2
k59_36344_3	1122933.JNIY01000003_gene463	1.42e-25	109.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,2GK3B@201174|Actinobacteria,4F260@85016|Cellulomonadaceae	201174|Actinobacteria	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	-	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CbiX,NAD_binding_7,TP_methylase
k59_1852597_1	1318628.MARLIPOL_09391	1.89e-22	92.8	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria,467AQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle	rsmD	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
k59_1495939_1	1049564.TevJSym_bb00010	1.52e-39	140.0	COG2878@1|root,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,1RPC4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Fe-S cluster	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4
k59_550480_1	572477.Alvin_2221	4.21e-91	288.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1WWT9@135613|Chromatiales	135613|Chromatiales	O	Belongs to the ClpA ClpB family	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_269877_1	1232683.ADIMK_0401	5.36e-25	95.1	COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,1S8UC@1236|Gammaproteobacteria,467T6@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	yciI	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K05527,ko:K09780	-	-	-	-	ko00000,ko03000	-	-	-	YCII
k59_269877_2	765912.Thimo_0967	1.57e-21	93.6	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,1S9DN@1236|Gammaproteobacteria,1WW5A@135613|Chromatiales	135613|Chromatiales	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3
k59_668428_1	580332.Slit_1219	1.77e-84	260.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,2VNB4@28216|Betaproteobacteria	28216|Betaproteobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA1	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
k59_844403_1	472175.EL18_02360	4.15e-45	147.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2UBRZ@28211|Alphaproteobacteria,43KCG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
k59_91330_1	1304883.KI912532_gene1106	9.44e-111	334.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2VI29@28216|Betaproteobacteria,2KUHE@206389|Rhodocyclales	206389|Rhodocyclales	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_913102_1	1313172.YM304_04020	2.02e-29	114.0	COG1290@1|root,COG1290@2|Bacteria,2H1Y8@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome b(C-terminal)/b6/petD	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C
k59_913102_2	1229780.BN381_450011	5.29e-10	58.5	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome b	-	-	-	ko:K03887	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrome_B
k59_1548154_1	1249627.D779_3482	2.69e-32	127.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,1RPKA@1236|Gammaproteobacteria,1WXPP@135613|Chromatiales	135613|Chromatiales	G	pfam mofrl	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
k59_433115_1	420662.Mpe_A1310	1.89e-50	171.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,2VNCV@28216|Betaproteobacteria,1KNHQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_844405_1	179408.Osc7112_1976	5.13e-13	74.7	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2461@1|root,COG3829@1|root,COG5000@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG2461@2|Bacteria,COG3829@2|Bacteria,COG5000@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k59_91339_1	909663.KI867150_gene334	4.15e-88	286.0	COG1994@1|root,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,42Q1P@68525|delta/epsilon subdivisions,2WM2R@28221|Deltaproteobacteria,2MRSH@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Peptidase M50	-	-	-	ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_668434_1	76114.ebA7287	4.33e-104	334.0	COG3378@1|root,COG4643@1|root,COG3378@2|Bacteria,COG4643@2|Bacteria,1QVIS@1224|Proteobacteria,2VPDW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Phage plasmid primase, P4 family domain protein	-	-	-	ko:K06919	-	-	-	-	ko00000	-	-	-	-
k59_550494_1	745411.B3C1_14183	3.42e-27	114.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1J52S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	MU	COG1538 Outer membrane protein	tolC	GO:0002790,GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008104,GO:0008150,GO:0009279,GO:0009306,GO:0009987,GO:0010033,GO:0014070,GO:0015031,GO:0015075,GO:0015267,GO:0015288,GO:0015318,GO:0015562,GO:0015688,GO:0015711,GO:0015833,GO:0015850,GO:0015891,GO:0015893,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022838,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032940,GO:0032991,GO:0033036,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0042886,GO:0042930,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0046618,GO:0046903,GO:0047485,GO:0050896,GO:0051179,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098796,GO:1901678,GO:1902495,GO:1990195,GO:1990196,GO:1990281,GO:1990351	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	iAPECO1_1312.APECO1_3378,iEC042_1314.EC042_3326,iECOK1_1307.ECOK1_3463	OEP
k59_972165_1	439235.Dalk_2765	2.19e-29	118.0	2E769@1|root,331Q7@2|Bacteria,1NEM5@1224|Proteobacteria,42WHJ@68525|delta/epsilon subdivisions,2WS1T@28221|Deltaproteobacteria,2MM54@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_384850_1	1157708.KB907450_gene5144	6.16e-105	314.0	COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2VJ5B@28216|Betaproteobacteria,4AC0Y@80864|Comamonadaceae	28216|Betaproteobacteria	S	2-nitropropane dioxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
k59_384851_1	2340.JV46_22540	3.6e-103	325.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1J57N@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_782057_1	429009.Adeg_1077	7.09e-32	125.0	COG1150@1|root,COG1150@2|Bacteria,1TRAM@1239|Firmicutes,24CFA@186801|Clostridia,42HT9@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K16887	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17
k59_1606347_1	396588.Tgr7_2910	3.07e-28	107.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1WX8T@135613|Chromatiales	135613|Chromatiales	K	Belongs to the UPF0301 (AlgH) family	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_1606347_2	1049564.TevJSym_bn00090	7.02e-34	125.0	COG0810@1|root,COG0810@2|Bacteria,1R330@1224|Proteobacteria,1RQAX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Periplasmic protein TonB links inner and outer membranes	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
k59_140200_1	1231057.AMGD01000001_gene2417	3.18e-54	188.0	COG0702@1|root,COG0702@2|Bacteria,1TT3N@1239|Firmicutes,4HB09@91061|Bacilli	91061|Bacilli	GM	NAD(P)H-binding	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10
k59_36387_1	472759.Nhal_3464	3.61e-56	180.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1S610@1236|Gammaproteobacteria,1WY2S@135613|Chromatiales	135613|Chromatiales	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate	tsaC	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
k59_36387_2	857087.Metme_4265	4.17e-50	177.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1XDRF@135618|Methylococcales	135618|Methylococcales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
k59_1606354_1	1121405.dsmv_3459	2.89e-58	188.0	COG2122@1|root,COG2122@2|Bacteria,1MV9Z@1224|Proteobacteria,42PMZ@68525|delta/epsilon subdivisions,2WMF7@28221|Deltaproteobacteria,2MJ13@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM ApbE family	-	-	-	ko:K09740	-	-	-	-	ko00000	-	-	-	-
k59_1087322_1	1120953.AUBH01000003_gene1965	6.03e-16	72.8	2E5J4@1|root,330AE@2|Bacteria,1QYT1@1224|Proteobacteria,1T3TB@1236|Gammaproteobacteria,46D5Y@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ykof
k59_316141_2	1380356.JNIK01000018_gene627	5.48e-39	137.0	COG0203@1|root,COG0203@2|Bacteria,2IHV2@201174|Actinobacteria,4ESN1@85013|Frankiales	201174|Actinobacteria	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
k59_269917_1	177437.HRM2_37830	2.43e-78	261.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MIWX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CoA-binding domain protein	acs	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_316145_1	1278307.KB906977_gene1640	1.4e-45	169.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,MASE1,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_1548179_1	1385519.N801_11495	5.05e-64	205.0	COG1612@1|root,COG1612@2|Bacteria,2GJQX@201174|Actinobacteria,4FG1S@85021|Intrasporangiaceae	201174|Actinobacteria	O	cytochrome oxidase assembly	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
k59_1548179_2	367299.JOEE01000005_gene3594	3.09e-12	64.7	COG0842@1|root,COG0842@2|Bacteria,2GN6S@201174|Actinobacteria,4FGAN@85021|Intrasporangiaceae	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
k59_1724538_1	580332.Slit_2732	4.03e-06	47.8	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2VI2C@28216|Betaproteobacteria,44UZR@713636|Nitrosomonadales	28216|Betaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_1724538_2	267608.RSc1534	2.6e-32	121.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2VIT4@28216|Betaproteobacteria,1K1SS@119060|Burkholderiaceae	28216|Betaproteobacteria	K	phosphate regulon transcriptional regulatory protein PhoB	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_384895_1	1158762.KB898040_gene1429	5.89e-32	119.0	COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,1RMYH@1236|Gammaproteobacteria,1WWPD@135613|Chromatiales	135613|Chromatiales	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
k59_384895_2	314285.KT71_00615	0.00064	42.4	COG3190@1|root,COG3190@2|Bacteria,1QJ8N@1224|Proteobacteria,1TH71@1236|Gammaproteobacteria,1JAA7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	N	Flagellar biosynthesis protein, FliO	-	-	-	-	-	-	-	-	-	-	-	-	FliO
k59_1667151_1	1249627.D779_0629	4.45e-142	420.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1WW4U@135613|Chromatiales	135613|Chromatiales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_668458_1	986075.CathTA2_0026	5.33e-54	184.0	COG2801@1|root,COG2801@2|Bacteria,1TT8V@1239|Firmicutes,4HCE5@91061|Bacilli	91061|Bacilli	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_29,rve
k59_1324400_1	515635.Dtur_0169	1.38e-58	187.0	COG0634@1|root,COG0634@2|Bacteria	2|Bacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	GO:0000287,GO:0003674,GO:0003824,GO:0004422,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006166,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032261,GO:0032263,GO:0032264,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0043167,GO:0043169,GO:0043173,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_91411_1	323848.Nmul_A0095	1.84e-82	266.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,372ME@32003|Nitrosomonadales	28216|Betaproteobacteria	I	AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_316155_1	380394.Lferr_1055	7.37e-81	252.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,1T20U@1236|Gammaproteobacteria,2NCF3@225057|Acidithiobacillales	225057|Acidithiobacillales	C	Nickel-dependent hydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
k59_316155_2	1232683.ADIMK_2537	1.29e-63	202.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,1RW0G@1236|Gammaproteobacteria,466Y9@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	hoxY	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
k59_913193_1	1280953.HOC_17030	8.35e-128	377.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_91425_1	1125863.JAFN01000001_gene771	9.83e-105	334.0	COG0464@1|root,COG0466@1|root,COG0464@2|Bacteria,COG0466@2|Bacteria,1R9P6@1224|Proteobacteria,42PYU@68525|delta/epsilon subdivisions,2WJW7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,Lon_C
k59_316159_1	935839.JAGJ01000008_gene1696	1.35e-68	211.0	COG0669@1|root,COG0669@2|Bacteria,2GN1S@201174|Actinobacteria,4F4ID@85017|Promicromonosporaceae	201174|Actinobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016043,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0022607,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034214,GO:0034641,GO:0034654,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0055086,GO:0065003,GO:0070566,GO:0071704,GO:0071840,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_316159_2	593907.Celgi_1161	8.5e-18	80.1	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4F1AX@85016|Cellulomonadaceae	201174|Actinobacteria	L	Conserved hypothetical protein 95	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
k59_922461_2	1458357.BG58_19520	2.99e-24	94.7	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2VSHQ@28216|Betaproteobacteria,1K7K5@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
k59_1672310_1	941449.dsx2_0365	2.47e-48	171.0	COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,42PU9@68525|delta/epsilon subdivisions,2WU8U@28221|Deltaproteobacteria,2M8K7@213115|Desulfovibrionales	28221|Deltaproteobacteria	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1862039_1	909663.KI867151_gene3057	7.39e-87	269.0	COG5441@1|root,COG5441@2|Bacteria,1MX45@1224|Proteobacteria,42N9G@68525|delta/epsilon subdivisions,2WMJS@28221|Deltaproteobacteria,2MR3I@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Uncharacterised protein family (UPF0261)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0261
k59_276689_1	1300345.LF41_2797	3.26e-72	222.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,1S36X@1236|Gammaproteobacteria,1X3XG@135614|Xanthomonadales	135614|Xanthomonadales	S	FeS assembly SUF system protein SufT	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
k59_276689_2	1033802.SSPSH_001126	2.18e-26	100.0	COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,1SAAA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Rieske 2Fe-2S	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
k59_1333736_1	999541.bgla_1g06550	1.39e-63	201.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2VHNY@28216|Betaproteobacteria,1JZTS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
k59_1333736_2	1123367.C666_06350	7.28e-14	70.5	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2VJD1@28216|Betaproteobacteria,2KUUS@206389|Rhodocyclales	206389|Rhodocyclales	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
k59_673700_1	251229.Chro_2353	9.74e-37	140.0	COG0438@1|root,COG0438@2|Bacteria,1GCX5@1117|Cyanobacteria	1117|Cyanobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1267335_1	1121406.JAEX01000003_gene1687	2.21e-37	142.0	28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,42NZH@68525|delta/epsilon subdivisions,2WKHB@28221|Deltaproteobacteria,2M9ZJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Cytochrome c bacterial	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_C7,Cytochrome_cB
k59_849498_1	582899.Hden_2607	1.22e-93	301.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,3N67I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_1093086_1	98439.AJLL01000016_gene1689	3.68e-55	189.0	COG1894@1|root,COG1894@2|Bacteria,1G2KY@1117|Cyanobacteria	1117|Cyanobacteria	C	NADH ubiquinone oxidoreductase NADH-binding (51 kD) subunit	hoxF	-	1.6.5.3	ko:K05587	ko00190,ko01100,map00190,map01100	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_1021253_1	768671.ThimaDRAFT_3308	2.31e-53	169.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,1S61Z@1236|Gammaproteobacteria,1WYKZ@135613|Chromatiales	135613|Chromatiales	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_203996_1	1121405.dsmv_1857	1.25e-38	140.0	28VGR@1|root,2ZHJ8@2|Bacteria,1RBS0@1224|Proteobacteria,42QZB@68525|delta/epsilon subdivisions,2WN03@28221|Deltaproteobacteria,2MJPZ@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_100565_1	105559.Nwat_0045	8.82e-119	372.0	COG1474@1|root,COG1474@2|Bacteria,1R5I2@1224|Proteobacteria,1RXXF@1236|Gammaproteobacteria,1WVZI@135613|Chromatiales	135613|Chromatiales	LO	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_614384_1	59538.XP_005957092.1	1.5e-91	278.0	COG1089@1|root,KOG1372@2759|Eukaryota,38I66@33154|Opisthokonta,3B9EK@33208|Metazoa,3CRXA@33213|Bilateria,481RW@7711|Chordata,48YAP@7742|Vertebrata,3J5M7@40674|Mammalia,4J3R2@91561|Cetartiodactyla	33208|Metazoa	G	GDP-mannose 4,6 dehydratase	Gmd	GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0007154,GO:0007165,GO:0007166,GO:0007219,GO:0007276,GO:0007281,GO:0007292,GO:0008150,GO:0008152,GO:0008446,GO:0009058,GO:0009225,GO:0009226,GO:0009636,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019673,GO:0019953,GO:0022412,GO:0022414,GO:0023052,GO:0030154,GO:0032501,GO:0032502,GO:0032504,GO:0034641,GO:0034654,GO:0042221,GO:0042350,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044703,GO:0046368,GO:0046483,GO:0048468,GO:0048477,GO:0048609,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051302,GO:0051704,GO:0051716,GO:0055086,GO:0065007,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576,GO:2000035	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
k59_1862066_1	1267533.KB906733_gene3362	1.52e-44	165.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
k59_922500_1	1123508.JH636458_gene240	2.89e-35	135.0	COG5433@1|root,COG5433@2|Bacteria,2IWUI@203682|Planctomycetes	203682|Planctomycetes	L	COG5433 Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_1672329_1	583345.Mmol_0016	8.1e-06	49.3	COG0861@1|root,COG0861@2|Bacteria,1MUNR@1224|Proteobacteria,2VJB9@28216|Betaproteobacteria	28216|Betaproteobacteria	P	membrane protein, terc	ygjT	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
k59_555737_1	59538.XP_005961908.1	2e-90	296.0	COG0458@1|root,KOG0370@2759|Eukaryota,38CAC@33154|Opisthokonta,3B9FF@33208|Metazoa,3CS9A@33213|Bilateria,4804V@7711|Chordata,497Y0@7742|Vertebrata,3JBZ5@40674|Mammalia,4IXTJ@91561|Cetartiodactyla	33208|Metazoa	F	Carbamoyl-phosphate synthase	-	-	-	-	-	-	-	-	-	-	-	-	CPSase_L_D2,CPSase_L_D3,CPSase_sm_chain,DapB_C,DapB_N,GATase,MGS
k59_1862074_1	1035308.AQYY01000001_gene3341	1.66e-74	235.0	COG0232@1|root,COG0232@2|Bacteria,1TPEI@1239|Firmicutes,247Q1@186801|Clostridia,26088@186807|Peptococcaceae	186801|Clostridia	F	Deoxyguanosinetriphosphate triphosphohydrolase	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_1093096_1	1265505.ATUG01000002_gene1619	2.6e-56	198.0	COG1148@1|root,COG2204@1|root,COG1148@2|Bacteria,COG2204@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MI9Y@213118|Desulfobacterales	28221|Deltaproteobacteria	CT	NAD(P)-binding Rossmann-like domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FAD_oxidored,Fer4,Fer4_7,NAD_binding_8,Pyr_redox_2,Response_reg
k59_849508_1	472759.Nhal_2893	5.26e-65	215.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1WXM2@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_276730_1	990285.RGCCGE502_07454	1.88e-17	77.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2TSI8@28211|Alphaproteobacteria,4B6XZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_100586_1	1121878.AUGL01000011_gene810	4.99e-21	92.4	2E42P@1|root,32YZ5@2|Bacteria,1N868@1224|Proteobacteria,1SCUM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	penicillin-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	BiPBP_C,DUF4124
k59_1862083_1	2340.JV46_13060	4.67e-11	63.5	COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,1RQ0T@1236|Gammaproteobacteria,1J5E5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	ldh	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_1862083_2	2340.JV46_13050	1.01e-58	191.0	COG1014@1|root,COG1144@1|root,COG1014@2|Bacteria,COG1144@2|Bacteria,1N12F@1224|Proteobacteria,1S7UK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
k59_555749_1	237368.SCABRO_03837	6.44e-41	150.0	29MQ2@1|root,308MT@2|Bacteria,2J179@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1139855_1	1035308.AQYY01000001_gene3237	2.71e-79	249.0	COG0446@1|root,COG0446@2|Bacteria,1V11U@1239|Firmicutes,25BW0@186801|Clostridia	186801|Clostridia	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1553226_2	330214.NIDE2833	9.8e-48	164.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1093121_1	1121035.AUCH01000019_gene2902	0.000108	43.5	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,2KUBF@206389|Rhodocyclales	206389|Rhodocyclales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
k59_1093121_2	765911.Thivi_3746	1.34e-49	166.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1WWVP@135613|Chromatiales	135613|Chromatiales	C	PFAM Cytochrome C1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
k59_497173_1	1449069.JMLO01000044_gene2955	7.38e-50	181.0	COG5280@1|root,COG5283@1|root,COG5280@2|Bacteria,COG5283@2|Bacteria,2I3FN@201174|Actinobacteria,4FXRG@85025|Nocardiaceae	201174|Actinobacteria	M	Phage-related minor tail protein	-	-	-	-	-	-	-	-	-	-	-	-	PhageMin_Tail
k59_321354_1	391619.PGA1_c23300	4.99e-45	165.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,34ECZ@302485|Phaeobacter	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase central domain	Sardh	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006575,GO:0006576,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008480,GO:0009056,GO:0009063,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019695,GO:0019752,GO:0019842,GO:0031406,GO:0031974,GO:0033218,GO:0034641,GO:0035999,GO:0036094,GO:0042133,GO:0042135,GO:0042219,GO:0042402,GO:0042426,GO:0042558,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046483,GO:0046653,GO:0046997,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072341,GO:0097159,GO:0097164,GO:1901052,GO:1901053,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.5.3.19	ko:K19191	ko00760,ko01120,map00760,map01120	-	R10102	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
k59_438435_1	96561.Dole_2278	1.85e-37	144.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria,2MMIR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_394117_2	765912.Thimo_2854	1.49e-113	331.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,1WVYC@135613|Chromatiales	135613|Chromatiales	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_276772_1	1157708.KB907456_gene2276	3.8e-84	263.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VJNN@28216|Betaproteobacteria,4A9S2@80864|Comamonadaceae	28216|Betaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_1729806_1	445974.CLORAM_00698	1.64e-61	209.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,3VP2S@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_732279_1	266940.Krad_1228	4.32e-107	342.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase E1 component	kgd	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1248c	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1553240_1	1121448.DGI_3104	3.47e-41	155.0	COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,42MA5@68525|delta/epsilon subdivisions,2WJGZ@28221|Deltaproteobacteria,2M9Y5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
k59_1611996_1	983545.Glaag_0644	1.09e-33	122.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,464GB@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG1137 ABC-type (unclassified) transport system, ATPase component	lptB	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
k59_1611996_2	1245471.PCA10_10310	5.24e-13	69.3	COG1934@1|root,COG1934@2|Bacteria,1N776@1224|Proteobacteria,1RPM7@1236|Gammaproteobacteria,1YENH@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm	lptA	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0010876,GO:0015920,GO:0016020,GO:0017089,GO:0019867,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044462,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901264	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	iB21_1397.B21_03016,iECBD_1354.ECBD_0542,iECB_1328.ECB_03065,iECD_1391.ECD_03065	OstA
k59_1863021_1	351016.RAZWK3B_01125	4.76e-113	340.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,2P20B@2433|Roseobacter	28211|Alphaproteobacteria	C	COG2303 Choline dehydrogenase and related flavoproteins	alkJ2	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_497799_2	1366046.HIMB11_00833	1e-24	102.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2U23D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_1672962_2	105559.Nwat_2753	6.57e-15	73.9	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria,1WX4U@135613|Chromatiales	135613|Chromatiales	T	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD_5
k59_204648_1	1292020.H483_0115355	2.86e-56	182.0	COG1989@1|root,COG1989@2|Bacteria,2GJ7K@201174|Actinobacteria	201174|Actinobacteria	NOU	Peptidase A24A, prepilin type IV	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	Peptidase_A24
k59_146092_1	1123401.JHYQ01000002_gene2646	1.88e-74	239.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,4600M@72273|Thiotrichales	72273|Thiotrichales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1140358_1	335543.Sfum_1831	1.74e-64	213.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MQWY@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	TIGRFAM ribonuclease, Rne Rng family	rne	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_1140358_2	555779.Dthio_PD1800	7.62e-62	204.0	COG3581@1|root,COG3581@2|Bacteria,1N1N8@1224|Proteobacteria,42UB7@68525|delta/epsilon subdivisions,2WQ9V@28221|Deltaproteobacteria,2MHJM@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_277595_1	1223521.BBJX01000009_gene1072	2.6e-41	154.0	2BXCB@1|root,2Z8QU@2|Bacteria,1MZ0I@1224|Proteobacteria,2VJPY@28216|Betaproteobacteria,4ACGR@80864|Comamonadaceae	28216|Betaproteobacteria	M	Participates in the degradation of poly-3- hydroxybutyrate (PHB). It works downstream of poly(3- hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers	phaZ2	-	3.1.1.22	ko:K07518	ko00650,map00650	-	R00048	RC00037,RC00094	ko00000,ko00001,ko01000	-	-	-	3HBOH
k59_982552_1	177437.HRM2_16660	3.5e-71	234.0	COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria,2MIRV@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit	-	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
k59_982552_2	96561.Dole_3185	1.72e-32	125.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MHKH@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
k59_1202967_1	1165841.SULAR_09254	2.3e-25	114.0	COG3547@1|root,COG3547@2|Bacteria,1NN5F@1224|Proteobacteria,42X06@68525|delta/epsilon subdivisions	1224|Proteobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_674348_1	1049564.TevJSym_ac00080	4.48e-25	100.0	COG1143@1|root,COG1143@2|Bacteria,1QWGE@1224|Proteobacteria,1SKS7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4
k59_674348_2	1430440.MGMSRv2_1424	1.5e-62	202.0	COG0348@1|root,COG0348@2|Bacteria,1MWR5@1224|Proteobacteria,2TS5E@28211|Alphaproteobacteria,2JQVY@204441|Rhodospirillales	28211|Alphaproteobacteria	C	4Fe-4S binding domain	-	-	-	ko:K02574	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_5
k59_1377923_1	420324.KI911970_gene1564	1.12e-15	75.9	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_1377923_2	1121878.AUGL01000021_gene2815	1.87e-156	458.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_1502461_1	172088.AUGA01000052_gene2729	3.46e-46	169.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,3JTU5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Alpha-2-Macroglobulin	MA20_30110	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,PAN_1,Thiol-ester_cl
k59_1553845_1	269796.Rru_A3160	8.15e-61	202.0	COG0697@1|root,COG0697@2|Bacteria,1R6KH@1224|Proteobacteria,2TTBR@28211|Alphaproteobacteria,2JS5P@204441|Rhodospirillales	204441|Rhodospirillales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_204664_1	246197.MXAN_4128	1.98e-72	234.0	COG2433@1|root,COG2433@2|Bacteria,1RE5Q@1224|Proteobacteria,42WSA@68525|delta/epsilon subdivisions,2WRPQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_1730397_3	1129192.A0A0E3D9B9_9CAUD	4.03e-11	65.5	4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses  no RNA stage,4QPDE@28883|Caudovirales,4QI6J@10662|Myoviridae	10662|Myoviridae	S	sequence-specific DNA binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_732915_1	1121405.dsmv_2622	8.34e-82	256.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42PZ6@68525|delta/epsilon subdivisions,2WKNQ@28221|Deltaproteobacteria,2MI1H@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Amino acid kinase family	-	-	1.1.1.3,2.7.2.4	ko:K00928,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3
k59_101578_1	1094491.BBbe_01600	4.42e-08	60.1	COG3637@1|root,COG3637@2|Bacteria,1MXV4@1224|Proteobacteria,2U0JD@28211|Alphaproteobacteria,48SXV@772|Bartonellaceae	28211|Alphaproteobacteria	M	Outer membrane protein beta-barrel domain	MA20_05570	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K16079	-	-	-	-	ko00000,ko02000	1.B.4.2.1	-	-	OMP_b-brl
k59_321963_1	314345.SPV1_11751	1.87e-105	321.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria	1224|Proteobacteria	C	glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_9,Pyr_redox_2,Pyr_redox_3
k59_982582_1	706587.Desti_3075	1.78e-45	155.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,42NS5@68525|delta/epsilon subdivisions,2WNQ5@28221|Deltaproteobacteria,2MQFJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
k59_732920_1	768671.ThimaDRAFT_1429	2.5e-129	374.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1WW6P@135613|Chromatiales	135613|Chromatiales	E	Belongs to the TrpC family	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PRAI
k59_786969_1	278957.ABEA03000201_gene4325	4.87e-79	256.0	COG0444@1|root,COG4608@1|root,COG0444@2|Bacteria,COG4608@2|Bacteria,46U8E@74201|Verrucomicrobia,3KA26@414999|Opitutae	414999|Opitutae	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_1730398_1	102232.GLO73106DRAFT_00020370	5.95e-139	396.0	COG0426@1|root,COG0426@2|Bacteria	2|Bacteria	C	nitric oxide reductase activity	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Fer4,Lactamase_B
k59_1730398_2	1235457.C404_26515	4.44e-91	280.0	COG0697@1|root,COG0697@2|Bacteria,1MXJ6@1224|Proteobacteria,2VIA7@28216|Betaproteobacteria,1K5U4@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1268063_1	1479239.JQMU01000001_gene472	1.56e-09	57.8	COG1734@1|root,COG1734@2|Bacteria,1N8K6@1224|Proteobacteria,2UCF1@28211|Alphaproteobacteria,2K7EE@204457|Sphingomonadales	204457|Sphingomonadales	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
k59_1268063_2	330214.NIDE0505	2.27e-19	82.4	COG4446@1|root,COG4446@2|Bacteria	2|Bacteria	P	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1499
k59_283504_1	1123392.AQWL01000005_gene3146	8.59e-26	110.0	COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,1MXH9@1224|Proteobacteria,2VK9C@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Uncharacterised conserved protein (DUF2156)	-	-	2.3.2.3	ko:K07027,ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	2.A.1.3.37,4.D.2	-	-	DUF2156,LPG_synthase_TM
k59_1207211_1	56110.Oscil6304_1462	2.55e-06	51.6	COG1538@1|root,COG1538@2|Bacteria,1G0B8@1117|Cyanobacteria,1H9AA@1150|Oscillatoriales	1117|Cyanobacteria	MU	outer membrane efflux protein	-	-	-	ko:K03287	-	-	-	-	ko00000	1.B.17	-	-	OEP
k59_737506_1	555779.Dthio_PD1636	6.34e-37	138.0	COG0642@1|root,COG2205@2|Bacteria,1QHXX@1224|Proteobacteria,42NW1@68525|delta/epsilon subdivisions,2WJUF@28221|Deltaproteobacteria,2M85B@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_1272989_1	667014.Thein_1060	2.51e-13	70.5	arCOG06116@1|root,30C51@2|Bacteria,2GHC9@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_326965_1	639283.Snov_3274	4.8e-107	313.0	COG0426@1|root,COG0426@2|Bacteria,1MXIE@1224|Proteobacteria,2U3GM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_403146_1	991905.SL003B_4155	6.64e-99	301.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2TRW2@28211|Alphaproteobacteria,4BPF3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_109626_1	506534.Rhein_0046	5.15e-14	75.1	COG0457@1|root,COG0457@2|Bacteria,1RFQA@1224|Proteobacteria,1S4HE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
k59_209714_1	713586.KB900536_gene2331	3.7e-55	184.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1WXCF@135613|Chromatiales	135613|Chromatiales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k59_1871179_2	593907.Celgi_0725	1.79e-114	338.0	COG1575@1|root,COG1575@2|Bacteria,2GJBS@201174|Actinobacteria,4F0II@85016|Cellulomonadaceae	201174|Actinobacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	GO:0003674,GO:0003824,GO:0004659,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_1871179_3	1123023.JIAI01000013_gene4019	3.1e-09	60.5	COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria,4E8QF@85010|Pseudonocardiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.42	ko:K18688	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_326972_2	1265313.HRUBRA_01473	2.22e-09	60.1	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria,1J8WI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	AMP-binding enzyme	JD73_00810	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C_2,PP-binding
k59_1342978_1	1121405.dsmv_1589	2.44e-64	208.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,42NBS@68525|delta/epsilon subdivisions,2WIP2@28221|Deltaproteobacteria,2MIE9@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1624	RibD_C,dCMP_cyt_deam_1
k59_561288_1	1463909.KL585957_gene2958	1.49e-119	364.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria	201174|Actinobacteria	G	hydrolase, family 3	bgl2	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_51596_1	1335757.SPICUR_09435	1.53e-37	131.0	COG5002@1|root,COG5002@2|Bacteria,1R2EY@1224|Proteobacteria,1T5PC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	PAS_9
k59_326976_1	497321.C664_06908	1.13e-13	71.2	COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,2VJUC@28216|Betaproteobacteria,2KW9J@206389|Rhodocyclales	206389|Rhodocyclales	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
k59_284323_1	1267534.KB906754_gene3776	8.97e-80	248.0	COG1005@1|root,COG1005@2|Bacteria,3Y6TS@57723|Acidobacteria,2JKJQ@204432|Acidobacteriia	204432|Acidobacteriia	C	NADH dehydrogenase	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_1207867_1	1121920.AUAU01000007_gene543	4.07e-35	132.0	COG0604@1|root,COG0604@2|Bacteria,3Y4X4@57723|Acidobacteria	57723|Acidobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1792020_1	768671.ThimaDRAFT_0802	8.97e-104	317.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVK@1236|Gammaproteobacteria,1X2B5@135613|Chromatiales	1236|Gammaproteobacteria	NU	PFAM Sulphatase-modifying factor	-	-	-	ko:K20333	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	FGE-sulfatase,PEGA,Pkinase
k59_326981_1	269797.Mbar_A1944	8.89e-07	57.0	COG2203@1|root,arCOG02350@1|root,arCOG03567@1|root,arCOG02350@2157|Archaea,arCOG02356@2157|Archaea,arCOG03567@2157|Archaea,2Y7RJ@28890|Euryarchaeota	28890|Euryarchaeota	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_3
k59_1558956_1	713586.KB900536_gene836	4.46e-106	335.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,1WW62@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_738199_1	714943.Mucpa_5701	3.13e-25	102.0	COG2801@1|root,COG2801@2|Bacteria,4NIBY@976|Bacteroidetes,1ITSB@117747|Sphingobacteriia	976|Bacteroidetes	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_738199_2	278963.ATWD01000001_gene3739	6.45e-28	103.0	COG2963@1|root,COG2963@2|Bacteria,3Y86J@57723|Acidobacteria,2JN6K@204432|Acidobacteriia	204432|Acidobacteriia	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_1871214_2	880072.Desac_0866	2.81e-54	175.0	COG1011@1|root,COG1011@2|Bacteria,1NH15@1224|Proteobacteria,43CH0@68525|delta/epsilon subdivisions,2X7S8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_444084_1	768671.ThimaDRAFT_1752	3.19e-98	303.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1WXP7@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2
k59_619922_1	439235.Dalk_1103	8.36e-126	369.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,42MMB@68525|delta/epsilon subdivisions,2WJEI@28221|Deltaproteobacteria,2MIFI@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2910	ThiC_Rad_SAM
k59_1144763_1	1380394.JADL01000002_gene1594	5.07e-87	269.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2TRVF@28211|Alphaproteobacteria,2JQ5N@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
k59_1207887_1	387093.SUN_2382	1.85e-42	152.0	COG2067@1|root,COG2067@2|Bacteria,1RJIQ@1224|Proteobacteria	1224|Proteobacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1343031_2	396588.Tgr7_0556	8.21e-87	268.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,1RQNF@1236|Gammaproteobacteria,1X02W@135613|Chromatiales	135613|Chromatiales	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_1617223_1	177437.HRM2_26230	1.47e-35	129.0	COG5421@1|root,COG5421@2|Bacteria,1R6MI@1224|Proteobacteria,42U8I@68525|delta/epsilon subdivisions,2WQCY@28221|Deltaproteobacteria,2MNWM@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1207891_1	713586.KB900536_gene651	3.15e-131	400.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WW6D@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_1735356_2	1260251.SPISAL_07385	3.87e-14	67.0	COG1841@1|root,COG1841@2|Bacteria,1N6ZE@1224|Proteobacteria,1SC8N@1236|Gammaproteobacteria,1WZ8N@135613|Chromatiales	135613|Chromatiales	J	Ribosomal protein L30	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
k59_1508081_1	1453501.JELR01000001_gene3240	1.21e-14	76.6	28MBM@1|root,2ZAQ2@2|Bacteria,1R5V6@1224|Proteobacteria,1S0K0@1236|Gammaproteobacteria,4662R@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1508081_2	243161.TC_0575	3.26e-09	60.8	COG0515@1|root,COG0515@2|Bacteria,2JFQ8@204428|Chlamydiae	204428|Chlamydiae	F	Together with the serine threonine kinase Pkn1, may play a role in the specific interactions with host proteins during intracellular growth	pknD	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_109697_1	1120953.AUBH01000004_gene3155	1.58e-101	323.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,465F9@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_1343040_1	1032480.MLP_30780	2.55e-89	291.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4DN7Q@85009|Propionibacteriales	201174|Actinobacteria	C	2-oxoglutarate dehydrogenase	kgd	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1248c	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1443124_1	1123393.KB891316_gene1321	1.43e-24	100.0	COG4659@1|root,COG4659@2|Bacteria,1RDEP@1224|Proteobacteria,2VS39@28216|Betaproteobacteria,1KSUU@119069|Hydrogenophilales	119069|Hydrogenophilales	C	FMN_bind	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
k59_1443124_2	396588.Tgr7_2629	1.45e-95	290.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,1WX3R@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
k59_931634_1	1187848.AJYQ01000008_gene535	1.66e-67	218.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,1RQ31@1236|Gammaproteobacteria,1XV2J@135623|Vibrionales	135623|Vibrionales	E	COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_444108_1	566466.NOR53_304	2.24e-138	400.0	COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,1RMH8@1236|Gammaproteobacteria,1J6DT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	transport system, permease component	yejB	-	-	ko:K13894	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1
k59_1207900_1	713586.KB900536_gene532	1.05e-20	91.3	COG2367@1|root,COG2367@2|Bacteria,1R6KF@1224|Proteobacteria	1224|Proteobacteria	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
k59_1207900_2	314345.SPV1_06999	2.21e-51	175.0	COG2367@1|root,COG2367@2|Bacteria,1R4Y9@1224|Proteobacteria	1224|Proteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase2
k59_284372_1	1569209.BBPH01000040_gene2183	6.44e-45	157.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,2PV42@265|Paracoccus	28211|Alphaproteobacteria	EP	Oligopeptide/dipeptide transporter, C-terminal region	oppD	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_284372_2	630626.EBL_c19050	1.19e-100	303.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,1SKPD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the ABC transporter superfamily	oppF	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K10823,ko:K12372	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00324,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	iAPECO1_1312.APECO1_362,iECOK1_1307.ECOK1_1402,iECS88_1305.ECS88_1315,iUMN146_1321.UM146_10835,iUTI89_1310.UTI89_C1445	ABC_tran,oligo_HPY
k59_1026016_1	1158182.KB905020_gene2022	6.99e-239	678.0	COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,1RN9V@1236|Gammaproteobacteria,1WWU3@135613|Chromatiales	135613|Chromatiales	C	UPF0313 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
k59_51644_1	1239962.C943_00983	3.53e-67	217.0	COG0025@1|root,COG0025@2|Bacteria,4NM79@976|Bacteroidetes,47U8Y@768503|Cytophagia	976|Bacteroidetes	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_738234_1	1117647.M5M_10045	4.81e-16	79.7	COG3568@1|root,COG3568@2|Bacteria,1RJZP@1224|Proteobacteria,1TH72@1236|Gammaproteobacteria,1JABN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_738234_2	1300345.LF41_2234	2.45e-15	74.3	2CKE6@1|root,32ZEV@2|Bacteria,1NBRM@1224|Proteobacteria,1SCY3@1236|Gammaproteobacteria,1X8E5@135614|Xanthomonadales	135614|Xanthomonadales	S	Family of unknown function (DUF5329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5329
k59_403255_1	1382359.JIAL01000001_gene413	4.55e-17	88.2	COG0617@1|root,COG0617@2|Bacteria,3Y3B8@57723|Acidobacteria,2JIIS@204432|Acidobacteriia	204432|Acidobacteriia	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
k59_109724_1	572477.Alvin_1488	5.97e-80	261.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1WWSC@135613|Chromatiales	135613|Chromatiales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_403256_1	273068.TTE2787	9.17e-13	72.8	COG1597@1|root,COG1597@2|Bacteria,1TQAU@1239|Firmicutes,25CN4@186801|Clostridia,42FCN@68295|Thermoanaerobacterales	186801|Clostridia	I	Diacylglycerol kinase catalytic domain (presumed)	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
k59_855174_1	933262.AXAM01000004_gene2414	1.5e-30	124.0	COG1196@1|root,COG4717@1|root,COG1196@2|Bacteria,COG4717@2|Bacteria,1MVAW@1224|Proteobacteria,42MYC@68525|delta/epsilon subdivisions,2WJXA@28221|Deltaproteobacteria,2MJBC@213118|Desulfobacterales	28221|Deltaproteobacteria	D	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_27
k59_990855_1	1082931.KKY_2386	4.67e-109	335.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2TW3X@28211|Alphaproteobacteria,3N7JR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_8,PAS_9,Sigma54_activat
k59_1678091_1	933262.AXAM01000006_gene1865	4.98e-34	133.0	COG3064@1|root,COG3064@2|Bacteria,1N60E@1224|Proteobacteria,42W12@68525|delta/epsilon subdivisions,2WRI0@28221|Deltaproteobacteria,2MKYV@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
k59_679652_1	1122915.AUGY01000008_gene5082	9.11e-40	144.0	COG4586@1|root,COG4586@2|Bacteria,1TP1N@1239|Firmicutes,4HEB4@91061|Bacilli,26Q9J@186822|Paenibacillaceae	91061|Bacilli	S	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1559024_1	713587.THITH_17355	1.81e-79	261.0	COG3173@1|root,COG3320@1|root,COG3173@2|Bacteria,COG3320@2|Bacteria	2|Bacteria	Q	fatty-acyl-CoA reductase (alcohol-forming) activity	-	-	2.1.1.179,2.7.9.2	ko:K01007,ko:K18845	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	br01600,ko00000,ko00001,ko00002,ko01000,ko01504,ko03009	-	-	-	APH,NAD_binding_4,PP-binding
k59_1273753_1	1116369.KB890024_gene2133	3.03e-38	143.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2U0K2@28211|Alphaproteobacteria,43J1F@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	N-acetylmuramoyl-L-alanine amidase	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
k59_1207928_1	420662.Mpe_A0392	1.34e-68	211.0	2BVFD@1|root,32QUS@2|Bacteria,1RHF0@1224|Proteobacteria,2VT3V@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Electron transfer DM13	-	-	-	-	-	-	-	-	-	-	-	-	DM13
k59_1559028_1	706587.Desti_3270	3.37e-75	254.0	COG2202@1|root,COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_990877_2	471853.Bcav_2899	4.1e-41	148.0	COG2816@1|root,COG2816@2|Bacteria,2GJZY@201174|Actinobacteria	201174|Actinobacteria	L	NADH pyrophosphatase	nudC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
k59_1617275_1	930945.SiRe_1558	1.06e-33	126.0	COG0010@1|root,arCOG01700@2157|Archaea,2XQGD@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
k59_403284_2	768671.ThimaDRAFT_3302	5.39e-52	177.0	COG3900@1|root,COG3900@2|Bacteria,1RKQP@1224|Proteobacteria,1SB83@1236|Gammaproteobacteria,1WYUH@135613|Chromatiales	135613|Chromatiales	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
k59_284404_1	95619.PM1_0222375	5.72e-08	54.7	28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1329
k59_284404_2	686578.AFFX01000004_gene3707	1.01e-15	80.9	COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,1RPY8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Protein of unknown function (DUF1302)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1302
k59_1026038_1	1194972.MVAC_27054	2.84e-36	147.0	COG2244@1|root,COG2273@1|root,COG2244@2|Bacteria,COG2273@2|Bacteria,2GMYJ@201174|Actinobacteria,237YV@1762|Mycobacteriaceae	201174|Actinobacteria	G	Hydrolase Family 16	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3
k59_327058_1	673860.AciM339_1486	4.82e-60	207.0	COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,3F2JF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_403298_1	240016.ABIZ01000001_gene1668	4.96e-52	175.0	COG3239@1|root,COG3239@2|Bacteria,46SX7@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Fatty acid desaturase	desA	-	1.14.19.23,1.14.19.45	ko:K10255	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
k59_502769_1	296591.Bpro_4602	5.82e-124	364.0	COG2423@1|root,COG2423@2|Bacteria,1MWH6@1224|Proteobacteria,2VHIM@28216|Betaproteobacteria,4ABP6@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM Ornithine cyclodeaminase mu-crystallin	arcB	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
k59_109789_1	488538.SAR116_2098	1.27e-76	237.0	COG0600@1|root,COG0600@2|Bacteria,1MV2D@1224|Proteobacteria,2TRF2@28211|Alphaproteobacteria,4BTA8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	MA20_14885	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_109789_2	488538.SAR116_2099	1.28e-23	96.7	COG1116@1|root,COG1116@2|Bacteria,1N7FP@1224|Proteobacteria,2TRKZ@28211|Alphaproteobacteria,4BR7S@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
k59_1383277_1	765913.ThidrDRAFT_1692	1.94e-86	259.0	COG3677@1|root,COG3677@2|Bacteria,1NUTK@1224|Proteobacteria,1S11R@1236|Gammaproteobacteria,1WZ4K@135613|Chromatiales	135613|Chromatiales	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_1617302_1	95619.PM1_0211680	6.1e-58	194.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	GO:0003674,GO:0003824,GO:0004149,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008289,GO:0009060,GO:0009987,GO:0015980,GO:0016417,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016751,GO:0016999,GO:0017144,GO:0019752,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:0140096,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1352,iECED1_1282.ECED1_0696,iECOK1_1307.ECOK1_0726,iECS88_1305.ECS88_0752,iLF82_1304.LF82_2196,iNRG857_1313.NRG857_03235,iUMN146_1321.UM146_13990,iUTI89_1310.UTI89_C0722	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_109792_1	479432.Sros_8977	6.76e-89	266.0	COG0047@1|root,COG0047@2|Bacteria,2GMJY@201174|Actinobacteria,4EHQD@85012|Streptosporangiales	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
k59_620006_1	1249627.D779_1480	1.11e-84	270.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RR0R@1236|Gammaproteobacteria,1WWF9@135613|Chromatiales	1236|Gammaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1871341_1	471853.Bcav_1892	4.83e-109	318.0	COG1845@1|root,COG1845@2|Bacteria,2GKK8@201174|Actinobacteria	201174|Actinobacteria	C	cytochrome c oxidase, subunit III	ctaE	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
k59_209837_1	266835.14025318	1.16e-134	398.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,43NZA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF4994,Sulfatase,Sulfatase_C
k59_1207958_1	1499686.BN1079_00125	7.95e-87	267.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043170,GO:0044425,GO:0044459,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901564	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_1792112_1	706587.Desti_1926	8.14e-25	100.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,42M7N@68525|delta/epsilon subdivisions,2WM4F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.10.3.10,1.9.3.1	ko:K02275,ko:K02297	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081,R11335	RC00016,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX2,COX2_TM,COX_ARM,Cytochrom_C,Cytochrome_CBB3
k59_861901_2	1294143.H681_15305	4.42e-76	251.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_334395_1	367299.JOEE01000005_gene3434	9.99e-83	262.0	COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria,4FEM6@85021|Intrasporangiaceae	201174|Actinobacteria	L	May be involved in recombinational repair of damaged DNA	recN	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
k59_1742756_1	329726.AM1_5602	2e-58	210.0	COG0577@1|root,COG0577@2|Bacteria,1G04T@1117|Cyanobacteria	1117|Cyanobacteria	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1107127_1	644283.Micau_2993	6.3e-95	300.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4DAXC@85008|Micromonosporales	201174|Actinobacteria	G	Alpha-amylase domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_745233_1	1380354.JIAN01000008_gene3384	4.26e-50	174.0	COG3288@1|root,COG3288@2|Bacteria,2I2FZ@201174|Actinobacteria,4F0ZY@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM alanine dehydrogenase PNT domain protein	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
k59_745233_2	996637.SGM_5924	5.53e-39	142.0	COG1694@1|root,COG3956@2|Bacteria,2GNKC@201174|Actinobacteria	201174|Actinobacteria	S	PFAM MazG nucleotide pyrophosphohydrolase	mazG	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0022607,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0035539,GO:0042454,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0047693,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
k59_509916_1	290397.Adeh_3712	2.87e-98	308.0	COG1164@1|root,COG1164@2|Bacteria,1Q3C4@1224|Proteobacteria,4393F@68525|delta/epsilon subdivisions,2X49B@28221|Deltaproteobacteria,2YYJ7@29|Myxococcales	28221|Deltaproteobacteria	E	Oligoendopeptidase f	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_451213_1	765914.ThisiDRAFT_1370	1.44e-73	232.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1T1HN@1236|Gammaproteobacteria,1WY5A@135613|Chromatiales	135613|Chromatiales	V	pfam abc	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1684956_1	671143.DAMO_1126	1.93e-98	309.0	COG2183@1|root,COG2183@2|Bacteria,2NP2S@2323|unclassified Bacteria	2|Bacteria	K	Tex-like protein N-terminal domain	yhgF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
k59_796595_1	314231.FP2506_04391	1.25e-108	316.0	COG2109@1|root,COG2109@2|Bacteria,1MUN6@1224|Proteobacteria,2TT92@28211|Alphaproteobacteria,2PKMM@255475|Aurantimonadaceae	28211|Alphaproteobacteria	H	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids	cobO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Co_AT_N,CobA_CobO_BtuR
k59_216554_1	748247.AZKH_3737	1.49e-107	321.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,2KVK1@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_216554_2	1122194.AUHU01000001_gene57	3.63e-33	122.0	COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,465BF@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis	rnt	GO:0000287,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360	-	ko:K03683	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_T
k59_1034039_2	96561.Dole_2658	3.45e-41	144.0	COG1092@1|root,COG1092@2|Bacteria,1QW1V@1224|Proteobacteria,42Q3P@68525|delta/epsilon subdivisions,2WJXM@28221|Deltaproteobacteria,2MHVR@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the methyltransferase superfamily	-	-	2.1.1.173,2.1.1.191,2.1.1.264	ko:K06969,ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
k59_627206_1	472759.Nhal_3203	2.02e-78	258.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1WW51@135613|Chromatiales	135613|Chromatiales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_861943_1	631362.Thi970DRAFT_02605	1.17e-80	256.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1WXXQ@135613|Chromatiales	135613|Chromatiales	G	Alpha amylase catalytic	-	-	2.4.1.7	ko:K00690	ko00500,map00500	-	R00803	RC00028	ko00000,ko00001,ko01000	-	GH13	-	-
k59_216560_1	1380394.JADL01000005_gene5444	3.15e-57	202.0	COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2TW4K@28211|Alphaproteobacteria,2JPWC@204441|Rhodospirillales	204441|Rhodospirillales	G	4-alpha-glucanotransferase	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_1684977_1	631362.Thi970DRAFT_04429	2.16e-98	319.0	COG3264@1|root,COG4942@1|root,COG3264@2|Bacteria,COG4942@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1X0ES@135613|Chromatiales	135613|Chromatiales	DM	PFAM Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,MscS_TM,MscS_porin
k59_509951_1	720554.Clocl_1328	4.59e-42	150.0	COG1208@1|root,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,24AGU@186801|Clostridia,3WGZX@541000|Ruminococcaceae	186801|Clostridia	M	MobA-like NTP transferase domain	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
k59_1034051_1	754476.Q7A_2526	1.02e-70	227.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,1RPBT@1236|Gammaproteobacteria,460BE@72273|Thiotrichales	72273|Thiotrichales	EGP	major facilitator superfamily	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
k59_1449997_1	566466.NOR53_413	3.12e-132	383.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria,1J4JS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0042380,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046490,GO:0048037,GO:0051536,GO:0051538,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI1_1343.ECIAI1_0030,iECW_1372.ECW_m0028,iEKO11_1354.EKO11_3884,iEcHS_1320.EcHS_A0031,iEcolC_1368.EcolC_3626,iPC815.YPO0477,iSFV_1184.SFV_0023,iSF_1195.SF0026,iSFxv_1172.SFxv_0027,iS_1188.S0028,iWFL_1372.ECW_m0028,iYL1228.KPN_00024	LYTB
k59_1565765_1	768066.HELO_3012	6.54e-82	268.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1XI1F@135619|Oceanospirillales	135619|Oceanospirillales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1798190_1	1234364.AMSF01000068_gene2137	1.41e-69	218.0	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,1S5DB@1236|Gammaproteobacteria,1X4XD@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF502)	YH67_14670	-	-	-	-	-	-	-	-	-	-	-	DUF502
k59_568438_2	1282356.H045_13010	2.52e-70	221.0	COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,1RMZ2@1236|Gammaproteobacteria,1YMD4@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	D	Belongs to the ParA family	fleN	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	ParA
k59_568440_1	545695.TREAZ_0100	1.35e-105	322.0	COG1155@1|root,COG1155@2|Bacteria,2J59J@203691|Spirochaetes	203691|Spirochaetes	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_451253_1	498211.CJA_2486	9.29e-85	275.0	COG2755@1|root,COG2755@2|Bacteria,1R43M@1224|Proteobacteria,1RRTK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2,TPR_19
k59_568443_1	1121920.AUAU01000004_gene813	2.52e-17	87.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3V0@57723|Acidobacteria	57723|Acidobacteria	EU	peptidase S9B dipeptidylpeptidase IV domain protein	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
k59_159351_2	1208323.B30_09088	1.56e-05	46.6	COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria,2TW3I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0025 NhaP-type Na H and K H antiporters	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
k59_335590_1	446471.Xcel_1988	6.23e-84	268.0	COG0187@1|root,COG0187@2|Bacteria,2GM1E@201174|Actinobacteria,4F3SU@85017|Promicromonosporaceae	201174|Actinobacteria	L	DNA topoisomerase type IIA subunit B region 2	gyrB2	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_1516946_1	1386089.N865_08665	3.78e-71	224.0	COG0175@1|root,COG0175@2|Bacteria,2GN85@201174|Actinobacteria,4FF69@85021|Intrasporangiaceae	201174|Actinobacteria	EH	With CysN catalyzes the formation of adenylylsulfate from sulfate and ATP	cysD	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
k59_863162_1	1041142.ATTP01000003_gene3399	0.000749	47.8	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16,TPR_19
k59_1516956_1	1380354.JIAN01000006_gene723	3.07e-49	161.0	2D9MJ@1|root,32TTI@2|Bacteria,2IFFM@201174|Actinobacteria,4F1DJ@85016|Cellulomonadaceae	201174|Actinobacteria	C	Belongs to the cytochrome c oxidase bacterial subunit CtaF family	ctaF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Cyt_c_ox_IV
k59_687608_1	1122201.AUAZ01000012_gene1386	1.04e-47	166.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,1RSPM@1236|Gammaproteobacteria,465Z2@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
k59_1451218_1	1123065.ATWL01000001_gene567	4.98e-74	241.0	COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria	201174|Actinobacteria	L	May be involved in recombinational repair of damaged DNA	recN	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
k59_1152023_1	1236959.BAMT01000008_gene2527	8.39e-44	146.0	COG3752@1|root,COG3752@2|Bacteria,1MXCP@1224|Proteobacteria,2VQHY@28216|Betaproteobacteria,2KKZM@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
k59_1152023_2	2850.Phatr48517	9.88e-10	60.5	COG2230@1|root,2QQW3@2759|Eukaryota,2XAFB@2836|Bacillariophyta	2836|Bacillariophyta	M	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	CMAS
k59_159383_1	713587.THITH_16080	6.87e-32	123.0	COG0596@1|root,COG0596@2|Bacteria,1RJQK@1224|Proteobacteria,1SAH5@1236|Gammaproteobacteria,1X142@135613|Chromatiales	135613|Chromatiales	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1516995_1	1254432.SCE1572_48330	8.72e-25	97.1	COG0776@1|root,COG0776@2|Bacteria,1RFWH@1224|Proteobacteria	1224|Proteobacteria	L	Belongs to the bacterial histone-like protein family	hupA	-	-	-	-	-	-	-	-	-	-	-	Bac_DNA_binding
k59_1686212_2	78245.Xaut_0634	5.04e-31	116.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TTKG@28211|Alphaproteobacteria,3EYHQ@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Guanylate_cyc,Response_reg,Trans_reg_C
k59_1108418_1	446469.Sked_09370	1.51e-11	69.3	COG1040@1|root,COG1040@2|Bacteria,2I9PA@201174|Actinobacteria	201174|Actinobacteria	S	phosphoribosyltransferase	pyrE_1	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
k59_159393_1	765912.Thimo_2547	1.45e-24	100.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1WXND@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
k59_159393_2	765910.MARPU_11540	7.33e-16	77.4	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1WX7K@135613|Chromatiales	135613|Chromatiales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_863211_1	1026882.MAMP_00438	3.74e-90	279.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,4603K@72273|Thiotrichales	72273|Thiotrichales	O	magnesium chelatase	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_452358_1	945550.VISI1226_14308	6.11e-54	182.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,1XT58@135623|Vibrionales	135623|Vibrionales	P	) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	GO:0003674,GO:0005215,GO:0005451,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_1686230_1	469371.Tbis_1650	4.02e-08	56.2	COG0517@1|root,COG0517@2|Bacteria,2GKSH@201174|Actinobacteria,4E49N@85010|Pseudonocardiales	201174|Actinobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
k59_1686230_2	383372.Rcas_0132	4.21e-07	52.0	arCOG06048@1|root,31EJQ@2|Bacteria,2G6TM@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1215956_1	1265505.ATUG01000002_gene1616	1.47e-98	318.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria,2MIN8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_1517031_1	1499967.BAYZ01000048_gene2700	9.5e-83	258.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2,MFS_3
k59_452366_1	158822.LH89_04100	3.44e-62	199.0	COG0329@1|root,COG0329@2|Bacteria,1MXI1@1224|Proteobacteria,1RRFC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_452366_2	1121403.AUCV01000028_gene2408	0.000363	42.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,42TDG@68525|delta/epsilon subdivisions,2WPJP@28221|Deltaproteobacteria,2MK47@213118|Desulfobacterales	28221|Deltaproteobacteria	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
k59_1686234_2	713586.KB900536_gene2226	2.58e-99	315.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
k59_511092_2	717785.HYPMC_2217	1.84e-38	140.0	COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,2TR0E@28211|Alphaproteobacteria,3N6KT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	phospho-2-dehydro-3-deoxyheptonate aldolase	aroF	GO:0003674,GO:0003824,GO:0003849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009507,GO:0009536,GO:0009611,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0050896,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
k59_1517039_1	479432.Sros_3455	1.14e-58	205.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	toxC	-	-	ko:K20332	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Pkinase,TPR_16,WD40
k59_1566842_1	765911.Thivi_3471	9.98e-56	182.0	COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,1RMUT@1236|Gammaproteobacteria,1WX1H@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
k59_569543_1	292415.Tbd_1555	2.4e-121	360.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2WH9U@28216|Betaproteobacteria,1KSZQ@119069|Hydrogenophilales	119069|Hydrogenophilales	I	Biotin carboxylase C-terminal domain	-	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_1282825_1	1267005.KB911264_gene3192	6.18e-150	455.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,3N648@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1744024_1	745014.OMB55_00020920	5.39e-65	223.0	COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria	1224|Proteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1625058_1	1278073.MYSTI_03686	4.11e-07	58.9	COG2356@1|root,COG4935@1|root,COG2356@2|Bacteria,COG4935@2|Bacteria,1MXQM@1224|Proteobacteria,42P2N@68525|delta/epsilon subdivisions,2WT6E@28221|Deltaproteobacteria,2YV8G@29|Myxococcales	28221|Deltaproteobacteria	L	Endonuclease I	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_1,P_proprotein
k59_1686250_1	1089455.MOPEL_078_00220	2.65e-29	110.0	COG1507@1|root,COG1507@2|Bacteria,2I8CS@201174|Actinobacteria,4F6XI@85018|Dermatophilaceae	201174|Actinobacteria	S	Protein of unknown function (DUF501)	-	-	-	ko:K09009	-	-	-	-	ko00000	-	-	-	DUF501
k59_1744031_1	472759.Nhal_2461	1.34e-30	116.0	COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,1RQIE@1236|Gammaproteobacteria,1X2GE@135613|Chromatiales	135613|Chromatiales	M	Belongs to the skp family	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
k59_1744031_2	1123399.AQVE01000027_gene31	6.08e-43	157.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,4604N@72273|Thiotrichales	72273|Thiotrichales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_1744032_1	663278.Ethha_0975	5.72e-63	207.0	COG1456@1|root,COG1456@2|Bacteria,1TPYJ@1239|Firmicutes,2588B@186801|Clostridia,3WHWI@541000|Ruminococcaceae	186801|Clostridia	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CdhD
k59_452397_2	1267005.KB911256_gene1817	2.31e-22	96.3	COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria,3N6F3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	glutamate--cysteine ligase	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GCS2
k59_1451297_1	1316936.K678_11815	4.77e-46	160.0	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2U0CA@28211|Alphaproteobacteria,2JS5Q@204441|Rhodospirillales	204441|Rhodospirillales	G	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
k59_569569_1	765911.Thivi_3478	1.45e-88	265.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria,1WWPE@135613|Chromatiales	135613|Chromatiales	G	HAD-superfamily hydrolase, subfamily IA, variant 3	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_1799183_2	1304865.JAGF01000001_gene3256	5.18e-123	362.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinP	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k59_1035346_1	1304865.JAGF01000001_gene1614	2.95e-148	447.0	COG0493@1|root,COG4624@1|root,COG0493@2|Bacteria,COG4624@2|Bacteria,2GJ0A@201174|Actinobacteria,4F0FS@85016|Cellulomonadaceae	201174|Actinobacteria	E	TIGRFAM glutamate synthase, NADH NADPH, small subunit	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2
k59_452409_1	983917.RGE_42250	2.8e-55	177.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2VR5S@28216|Betaproteobacteria,1KKUJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
k59_1216010_1	754476.Q7A_247	2.09e-70	224.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,46093@72273|Thiotrichales	72273|Thiotrichales	LU	TIGRFAM DNA protecting protein DprA	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_1391137_1	629773.AORY01000002_gene1451	1.04e-07	53.9	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2U99Y@28211|Alphaproteobacteria,2K54X@204457|Sphingomonadales	204457|Sphingomonadales	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
k59_1391137_2	1234364.AMSF01000075_gene1960	1.97e-14	72.4	COG0006@1|root,COG0006@2|Bacteria,1MURT@1224|Proteobacteria,1RMKT@1236|Gammaproteobacteria,1X3Z6@135614|Xanthomonadales	135614|Xanthomonadales	E	Splits dipeptides with a prolyl residue in the C- terminal position	pepQ	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_1451322_1	570967.JMLV01000003_gene2387	7.45e-101	313.0	COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,2TQUR@28211|Alphaproteobacteria,2JPYE@204441|Rhodospirillales	204441|Rhodospirillales	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
k59_1744074_1	717785.HYPMC_3126	2.86e-105	313.0	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,2TS96@28211|Alphaproteobacteria,3N7TC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	ArgK protein	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
k59_1566906_1	1120988.AXWV01000106_gene1731	1.63e-59	201.0	2E5W0@1|root,330K2@2|Bacteria,1NAEG@1224|Proteobacteria,1SSAN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4433
k59_1566906_2	1120988.AXWV01000061_gene420	8.02e-06	48.5	COG1397@1|root,COG1397@2|Bacteria,1NJFP@1224|Proteobacteria,1RQ82@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
k59_1391147_1	1123401.JHYQ01000007_gene542	3.9e-110	345.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,461JN@72273|Thiotrichales	72273|Thiotrichales	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_863307_1	1005995.GTPT_0571	3.54e-14	71.2	COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,1S402@1236|Gammaproteobacteria,4BV3K@82986|Tatumella	1236|Gammaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031225,GO:0032991,GO:0033177,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902600	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	e_coli_core.b3736,iAF1260.b3736,iB21_1397.B21_03564,iBWG_1329.BWG_3427,iE2348C_1286.E2348C_4046,iEC042_1314.EC042_4123,iEC55989_1330.EC55989_4211,iECABU_c1320.ECABU_c42210,iECBD_1354.ECBD_4296,iECB_1328.ECB_03620,iECDH10B_1368.ECDH10B_3923,iECDH1ME8569_1439.ECDH1ME8569_3624,iECD_1391.ECD_03620,iECED1_1282.ECED1_4426,iECH74115_1262.ECH74115_5172,iECIAI1_1343.ECIAI1_3920,iECIAI39_1322.ECIAI39_4340,iECO103_1326.ECO103_4422,iECO111_1330.ECO111_4570,iECO26_1355.ECO26_4842,iECOK1_1307.ECOK1_4185,iECP_1309.ECP_3935,iECS88_1305.ECS88_4158,iECSE_1348.ECSE_4026,iECSF_1327.ECSF_3584,iECSP_1301.ECSP_4786,iECUMN_1333.ECUMN_4266,iECW_1372.ECW_m4039,iECs_1301.ECs4678,iEKO11_1354.EKO11_4609,iETEC_1333.ETEC_4027,iEcDH1_1363.EcDH1_4231,iEcE24377_1341.EcE24377A_4252,iEcHS_1320.EcHS_A3952,iEcSMS35_1347.EcSMS35_4104,iEcolC_1368.EcolC_4258,iG2583_1286.G2583_4532,iJO1366.b3736,iJR904.b3736,iSDY_1059.SDY_4012,iSFV_1184.SFV_3762,iSF_1195.SF3816,iSFxv_1172.SFxv_4159,iSSON_1240.SSON_3883,iS_1188.S3952,iSbBS512_1146.SbBS512_E4185,iUMN146_1321.UM146_18870,iUMNK88_1353.UMNK88_4548,iUTI89_1310.UTI89_C4291,iWFL_1372.ECW_m4039,iY75_1357.Y75_RS18390,iZ_1308.Z5234,ic_1306.c4664	ATP-synt_B
k59_863307_2	1286106.MPL1_12186	1.27e-05	47.4	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,46125@72273|Thiotrichales	72273|Thiotrichales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
k59_1108546_1	371731.Rsw2DRAFT_1843	2.44e-42	151.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,2U0SB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K21834	-	-	-	-	ko00000	-	-	-	CCG,DUF3483,ETF,Fer4_10,Fer4_8
k59_1108546_2	1123393.KB891326_gene136	5.75e-23	97.4	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2VJ52@28216|Betaproteobacteria,1KSIG@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Nickel-dependent hydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
k59_687726_1	1049564.TevJSym_aw00360	6.58e-45	152.0	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,1S2ZH@1236|Gammaproteobacteria,1J8B0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulfur oxidation protein SoxY	soxY	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY
k59_1638526_2	1267005.KB911256_gene1969	9.58e-20	89.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,3N6KQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Sigma-54 interaction domain	tacA	GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat
k59_520558_1	1193181.BN10_630022	4.43e-08	53.1	COG0479@1|root,COG0479@2|Bacteria,2GJPS@201174|Actinobacteria,4FEDH@85021|Intrasporangiaceae	201174|Actinobacteria	C	succinate dehydrogenase	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
k59_520558_2	367299.JOEE01000007_gene228	1.34e-114	333.0	COG1266@1|root,COG1266@2|Bacteria,2GK11@201174|Actinobacteria,4FFNK@85021|Intrasporangiaceae	201174|Actinobacteria	S	protease	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_1700036_1	1163617.SCD_n02428	1.95e-52	187.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria	28216|Betaproteobacteria	G	SMART alpha amylase, catalytic sub domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_878228_1	1304872.JAGC01000009_gene1412	2.85e-57	179.0	COG0432@1|root,COG0432@2|Bacteria,1RA5G@1224|Proteobacteria,42QZ8@68525|delta/epsilon subdivisions,2WMV9@28221|Deltaproteobacteria,2MB2S@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
k59_1051653_1	717785.HYPMC_2980	1.25e-57	190.0	COG3719@1|root,COG3719@2|Bacteria,1PTUN@1224|Proteobacteria,2TQUU@28211|Alphaproteobacteria,3N8MD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the RNase T2 family	rns	-	3.1.27.1,3.1.27.6	ko:K01166,ko:K01169	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_T2
k59_1229802_1	317619.ANKN01000197_gene2312	1.5e-13	72.0	COG1215@1|root,COG1215@2|Bacteria,1GHF8@1117|Cyanobacteria,1MNF7@1212|Prochloraceae	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_230803_1	469383.Cwoe_4420	1.14e-56	190.0	COG3391@1|root,COG3391@2|Bacteria,2IIYP@201174|Actinobacteria	201174|Actinobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	NHL
k59_1581338_1	243233.MCA0338	9.97e-40	147.0	COG3291@1|root,COG3291@2|Bacteria,1R5MQ@1224|Proteobacteria,1TI1G@1236|Gammaproteobacteria,1XGA7@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c5530 family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1581338_2	330214.NIDE2857	3.87e-94	284.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_699935_1	748247.AZKH_2224	4.12e-33	127.0	COG2984@1|root,COG2984@2|Bacteria,1NACH@1224|Proteobacteria,2VSU8@28216|Betaproteobacteria,2KWT6@206389|Rhodocyclales	206389|Rhodocyclales	S	transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind
k59_699935_2	1123519.PSJM300_12390	1.9e-05	50.4	COG0642@1|root,COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1Z2D5@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	T	Histidine kinase	barA	GO:0000155,GO:0000160,GO:0000302,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009636,GO:0009927,GO:0009987,GO:0010033,GO:0010035,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0042493,GO:0042542,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046677,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901700	2.7.13.3	ko:K07678	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF2222,HAMP,HATPase_c,HisKA,Hpt,Response_reg
k59_639776_1	870187.Thini_1183	3.39e-145	419.0	COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,1RRMX@1236|Gammaproteobacteria,4604Y@72273|Thiotrichales	72273|Thiotrichales	G	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site	cbbL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
k59_639776_2	765914.ThisiDRAFT_1623	4.14e-56	176.0	COG4451@1|root,COG4451@2|Bacteria,1R9ZE@1224|Proteobacteria,1S3XZ@1236|Gammaproteobacteria,1X23Q@135613|Chromatiales	135613|Chromatiales	C	PFAM Ribulose bisphosphate carboxylase, small chain	-	-	4.1.1.39	ko:K01602	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_small
k59_759959_1	1122194.AUHU01000005_gene1121	7.08e-29	120.0	COG1330@1|root,COG2887@1|root,COG1330@2|Bacteria,COG2887@2|Bacteria,1QVX1@1224|Proteobacteria,1RP9I@1236|Gammaproteobacteria,465DQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	PD-(D/E)XK nuclease superfamily	lidB	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
k59_878242_1	290397.Adeh_3381	8.16e-54	190.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42PZF@68525|delta/epsilon subdivisions,2X5HR@28221|Deltaproteobacteria,2YYCV@29|Myxococcales	28221|Deltaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1755539_1	558169.AGAV01000015_gene378	5.38e-14	77.8	COG2027@1|root,COG2027@2|Bacteria,1TQFQ@1239|Firmicutes,4HA3X@91061|Bacilli	91061|Bacilli	M	D-alanyl-D-alanine carboxypeptidase	dacC	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
k59_759972_1	1035308.AQYY01000001_gene1580	4.88e-52	170.0	COG0517@1|root,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_699952_1	1158756.AQXQ01000006_gene94	1.75e-12	67.4	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1WVUV@135613|Chromatiales	135613|Chromatiales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_699952_2	395493.BegalDRAFT_2908	8.93e-49	167.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,46072@72273|Thiotrichales	72273|Thiotrichales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_520596_1	347834.RHE_CH03244	2.11e-14	76.6	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2TT0R@28211|Alphaproteobacteria,4BA5S@82115|Rhizobiaceae	28211|Alphaproteobacteria	GM	Belongs to the mannose-6-phosphate isomerase type 2 family	cpsB	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_1581364_1	794903.OPIT5_07350	2.68e-58	198.0	COG0772@1|root,COG0772@2|Bacteria,46SQT@74201|Verrucomicrobia,3K7H4@414999|Opitutae	414999|Opitutae	D	Belongs to the SEDS family	-	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_520610_1	118163.Ple7327_1609	6.34e-49	171.0	COG0430@1|root,COG0430@2|Bacteria,1G3A2@1117|Cyanobacteria	1117|Cyanobacteria	A	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	-	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
k59_1229846_1	1207076.ALAT01000183_gene3045	1.55e-53	180.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1Z1QF@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_1581369_1	61622.XP_010363778.1	3.46e-14	78.2	28IWW@1|root,2QR8M@2759|Eukaryota,38G0N@33154|Opisthokonta,3BCJK@33208|Metazoa,3CUA0@33213|Bilateria,4879X@7711|Chordata,48XBD@7742|Vertebrata,3JC5C@40674|Mammalia,35K96@314146|Euarchontoglires,4MFB7@9443|Primates,363Y6@314294|Cercopithecoidea	33208|Metazoa	T	kiaa0319	KIAA0319	GO:0001764,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005769,GO:0005886,GO:0006928,GO:0007275,GO:0007399,GO:0008150,GO:0009987,GO:0010721,GO:0010975,GO:0010977,GO:0012505,GO:0012506,GO:0016020,GO:0016043,GO:0016477,GO:0022008,GO:0030135,GO:0030136,GO:0030154,GO:0030659,GO:0030662,GO:0030665,GO:0031090,GO:0031344,GO:0031345,GO:0031410,GO:0031982,GO:0032501,GO:0032502,GO:0040011,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045595,GO:0045596,GO:0045664,GO:0045665,GO:0048519,GO:0048523,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0048870,GO:0050767,GO:0050768,GO:0050773,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0051128,GO:0051129,GO:0051179,GO:0051239,GO:0051241,GO:0051674,GO:0051960,GO:0051961,GO:0060284,GO:0061024,GO:0065007,GO:0071840,GO:0071944,GO:0097708,GO:0098588,GO:0098805,GO:0120035,GO:2000026,GO:2000171	-	-	-	-	-	-	-	-	-	-	REJ
k59_807734_1	243233.MCA1302	4.03e-121	355.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,1RMD9@1236|Gammaproteobacteria,1XEPK@135618|Methylococcales	135618|Methylococcales	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
k59_580935_1	933262.AXAM01000040_gene1232	2.2e-36	136.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2MHZN@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
k59_1051739_1	350054.Mflv_1617	3.86e-27	112.0	COG1770@1|root,COG1770@2|Bacteria,2GNA9@201174|Actinobacteria,233WC@1762|Mycobacteriaceae	201174|Actinobacteria	E	Oligopeptidase	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_1051739_2	1385521.N803_16495	1.32e-47	160.0	COG1741@1|root,COG1741@2|Bacteria,2GIY9@201174|Actinobacteria,4FG5R@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
k59_807736_1	1120960.ATXG01000001_gene1078	4.28e-50	172.0	COG0687@1|root,COG0687@2|Bacteria,2GKVG@201174|Actinobacteria,4FNX3@85023|Microbacteriaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055,ko:K11069	ko02010,ko02024,map02010,map02024	M00193,M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.11.1	-	-	SBP_bac_8,TAT_signal
k59_1700103_1	1304865.JAGF01000001_gene1790	3.59e-16	77.0	2E5CN@1|root,3304R@2|Bacteria,2I16Q@201174|Actinobacteria,4F1M2@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1700103_2	1123065.ATWL01000003_gene776	5.85e-89	272.0	COG1623@1|root,COG1623@2|Bacteria,2GJ41@201174|Actinobacteria	201174|Actinobacteria	L	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process	disA	-	2.7.7.85	ko:K07067	-	-	-	-	ko00000,ko01000	-	-	-	DisA-linker,DisA_N,HHH,HHH_2
k59_1810441_1	1205753.A989_06868	5.08e-13	72.8	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RMI7@1236|Gammaproteobacteria,1X38S@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K18298,ko:K19586	-	M00641,M00767	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2.47,8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
k59_1051763_1	335543.Sfum_1150	4.25e-52	175.0	COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42NUN@68525|delta/epsilon subdivisions,2WJHN@28221|Deltaproteobacteria,2MQS4@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Polysulphide reductase, NrfD	dsrP	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_1051763_2	1121403.AUCV01000004_gene2024	2.86e-39	139.0	COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,42MNU@68525|delta/epsilon subdivisions,2WJRG@28221|Deltaproteobacteria,2MIME@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	dsrO	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_4
k59_463913_1	1120963.KB894500_gene100	2.44e-112	341.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	oligopeptide transporter	-	-	-	-	-	-	-	-	-	-	-	-	OPT
k59_463919_1	380703.AHA_1519	2.46e-20	90.5	COG4106@1|root,COG4106@2|Bacteria,1QTS9@1224|Proteobacteria,1T1FG@1236|Gammaproteobacteria,1Y3NZ@135624|Aeromonadales	135624|Aeromonadales	S	Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM)	cmoA	-	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_25
k59_463919_2	1122137.AQXF01000005_gene1134	1.17e-18	84.7	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2TRUY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG0330 Membrane protease subunits stomatin prohibitin homologs	qmcA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
k59_348215_1	316274.Haur_2045	1.08e-59	206.0	COG3328@1|root,COG3328@2|Bacteria,2G6SX@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1163996_1	522306.CAP2UW1_3348	1.32e-103	321.0	COG3320@1|root,COG4221@1|root,COG3320@2|Bacteria,COG4221@2|Bacteria,1QSHC@1224|Proteobacteria,2VKRX@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Male sterility	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4,adh_short
k59_520645_1	1123518.ARWI01000001_gene1847	1.43e-45	168.0	COG2133@1|root,COG2373@1|root,COG2133@2|Bacteria,COG2373@2|Bacteria,1R65J@1224|Proteobacteria,1RYQV@1236|Gammaproteobacteria,461V8@72273|Thiotrichales	72273|Thiotrichales	G	Large extracellular alpha-helical protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_878351_1	192875.XP_004346368.1	1.88e-26	111.0	COG1024@1|root,KOG1684@2759|Eukaryota,38EBG@33154|Opisthokonta	33154|Opisthokonta	I	3-hydroxyisobutyryl-CoA hydrolase activity	HIBCH	GO:0003674,GO:0003824,GO:0003860,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009081,GO:0009083,GO:0009987,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019752,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0048519,GO:0048583,GO:0048585,GO:0050789,GO:0065007,GO:0070013,GO:0071704,GO:0080134,GO:1901564,GO:1901565,GO:1901575,GO:1903034,GO:1903035	3.1.2.4	ko:K05605	ko00280,ko00410,ko00640,ko01100,ko01200,map00280,map00410,map00640,map01100,map01200	M00013	R03158,R05064	RC00004,RC00014,RC00137	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_2
k59_807763_1	1249627.D779_0911	4.95e-56	184.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1WW00@135613|Chromatiales	135613|Chromatiales	H	Belongs to the ALAD family	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_1638657_1	1121405.dsmv_3745	1.13e-106	325.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,42M3N@68525|delta/epsilon subdivisions,2WISS@28221|Deltaproteobacteria,2MHQH@213118|Desulfobacterales	28221|Deltaproteobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_463926_1	2340.JV46_03100	5.75e-11	60.5	COG1030@1|root,COG1030@2|Bacteria	2|Bacteria	-	-	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
k59_463926_2	314345.SPV1_08266	3.25e-122	355.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria	1224|Proteobacteria	O	COG0330 Membrane protease subunits stomatin prohibitin homologs	qmcA	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_1810472_1	1144932.ATTF01000002_gene320	1.29e-19	87.4	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2TRXC@28211|Alphaproteobacteria,4BREN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_1810472_2	402881.Plav_1245	3.8e-53	170.0	COG1396@1|root,COG1396@2|Bacteria,1N1CT@1224|Proteobacteria,2UCMF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
k59_1810472_3	402881.Plav_1246	1.74e-16	76.3	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2UCM1@28211|Alphaproteobacteria,1JPFJ@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Smr domain	smrA	-	-	-	-	-	-	-	-	-	-	-	Smr
k59_1700153_1	1380370.JIBA01000012_gene3416	1.92e-16	73.6	COG1695@1|root,COG1695@2|Bacteria,2IQ8I@201174|Actinobacteria,4FHXQ@85021|Intrasporangiaceae	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_1638669_1	521393.JH806634_gene2104	2.24e-11	63.2	COG0586@1|root,COG0586@2|Bacteria,2GKGR@201174|Actinobacteria,4D49A@85005|Actinomycetales	201174|Actinobacteria	S	SNARE-like domain protein	dedA	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
k59_1638669_2	935839.JAGJ01000001_gene1225	2e-83	253.0	COG0566@1|root,COG0566@2|Bacteria,2GM1A@201174|Actinobacteria,4F3RM@85017|Promicromonosporaceae	201174|Actinobacteria	J	SpoU rRNA Methylase family	trmH	-	2.1.1.34	ko:K00556	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
k59_173080_1	85643.Tmz1t_4023	1.8e-35	133.0	COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2VIAV@28216|Betaproteobacteria,2KUHY@206389|Rhodocyclales	206389|Rhodocyclales	T	COG0631 Serine threonine protein phosphatase	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
k59_1164024_1	1454004.AW11_02882	2.25e-72	231.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,2VMP0@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Pfam Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_878371_2	367299.JOEE01000002_gene2434	3.92e-73	227.0	2DBB1@1|root,2Z854@2|Bacteria,2GNBN@201174|Actinobacteria,4FEXB@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of Unknown Function (DUF1206)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1206
k59_1755644_1	1049564.TevJSym_ac01700	3.87e-48	170.0	COG5607@1|root,COG5607@2|Bacteria,1R5I1@1224|Proteobacteria,1S0QK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	pfam chad	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,His_Phos_1
k59_1755652_1	1206726.BAFV01000123_gene6228	1.79e-35	134.0	COG1235@1|root,COG2087@1|root,COG1235@2|Bacteria,COG2087@2|Bacteria,2GM8Q@201174|Actinobacteria,4FYZ7@85025|Nocardiaceae	201174|Actinobacteria	H	Adenosyl cobinamide kinase adenosyl cobinamide phosphate guanylyltransferase	cobU	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU,Lactamase_B_2
k59_1053136_1	997346.HMPREF9374_0940	5.79e-46	168.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,4H9WW@91061|Bacilli,27AXP@186824|Thermoactinomycetaceae	91061|Bacilli	L	helicase superfamily c-terminal domain	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_808504_1	766499.C357_06921	5.22e-25	103.0	COG3666@1|root,COG3666@2|Bacteria,1QW5T@1224|Proteobacteria,2TWNW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase and inactivated derivatives	tnp*	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_808504_2	570952.ATVH01000017_gene1763	4.48e-40	144.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2U1C5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
k59_1053138_1	887898.HMPREF0551_0604	3.36e-38	133.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2VQ19@28216|Betaproteobacteria,1K20G@119060|Burkholderiaceae	28216|Betaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
k59_1053138_2	937774.TEQUI_1262	2.77e-19	79.7	COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,2VVS9@28216|Betaproteobacteria,3T4M5@506|Alcaligenaceae	28216|Betaproteobacteria	J	Ribosomal protein L35	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
k59_1639458_1	1123228.AUIH01000006_gene2238	2.26e-15	77.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,1XIS2@135619|Oceanospirillales	135619|Oceanospirillales	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1464725_2	1232410.KI421421_gene3768	4.06e-40	150.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,43S1Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_174050_1	247634.GPB2148_2650	8.13e-62	205.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	Glyco_hydro_17,MFS_2
k59_1053162_1	1317124.DW2_07872	9.23e-30	120.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2TR7W@28211|Alphaproteobacteria,2XKI3@285107|Thioclava	28211|Alphaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_231874_1	1122135.KB893157_gene195	6.17e-77	240.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_640729_1	367299.JOEE01000001_gene2055	3.28e-22	95.1	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,4FEYT@85021|Intrasporangiaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iNJ661.Rv3152	NADHdh
k59_640729_2	367299.JOEE01000001_gene2056	3.32e-120	346.0	COG1143@1|root,COG1143@2|Bacteria,2GJNU@201174|Actinobacteria,4FFGF@85021|Intrasporangiaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.6.5.3	ko:K00338,ko:K12143	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iNJ661.Rv3153	Fer4
k59_1165215_1	933262.AXAM01000106_gene2631	5.11e-38	138.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,42R11@68525|delta/epsilon subdivisions,2WMWN@28221|Deltaproteobacteria,2MMZB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_1165215_2	933262.AXAM01000106_gene2631	8.18e-28	111.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,42R11@68525|delta/epsilon subdivisions,2WMWN@28221|Deltaproteobacteria,2MMZB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_349146_1	765911.Thivi_3111	1.07e-94	282.0	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,1SBBX@1236|Gammaproteobacteria,1X060@135613|Chromatiales	135613|Chromatiales	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_1405573_1	1269813.ATUL01000001_gene1131	6.58e-95	284.0	COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,1RMVD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Inositol monophosphatase	-	-	3.1.3.15	ko:K05602	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_640753_1	1304865.JAGF01000001_gene2747	2.09e-74	233.0	COG2086@1|root,COG2086@2|Bacteria,2GKV6@201174|Actinobacteria,4F14Y@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM Electron transfer flavoprotein alpha	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_521529_1	1323663.AROI01000016_gene481	2.8e-27	104.0	COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,1S3XT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_1648669_1	1267005.KB911257_gene940	3.82e-104	309.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,3N72Q@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the HpcH HpaI aldolase family	citE	-	3.1.2.30,4.1.3.34	ko:K01644,ko:K14451	ko00630,ko01120,ko01200,ko02020,map00630,map01120,map01200,map02020	M00373	R00362,R10612	RC00004,RC00014,RC00067,RC01118	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
k59_533125_1	935548.KI912159_gene1376	3.83e-156	478.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,43H04@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EQ	Hydantoinase B/oxoprolinase	oplA	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_6468_1	1049564.TevJSym_bg00200	9.26e-73	231.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1J4G6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iB21_1397.B21_00243,iECBD_1354.ECBD_3376,iECB_1328.ECB_00240,iECD_1391.ECD_00240,iYL1228.KPN_00280	Aldedh
k59_1472533_1	593907.Celgi_0901	3.96e-130	390.0	COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,2GJ5U@201174|Actinobacteria,4F0GJ@85016|Cellulomonadaceae	201174|Actinobacteria	C	belongs to the CobB CobQ family	pta	GO:0005575,GO:0005576	2.3.1.8	ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,DRTGG,PTA_PTB
k59_298430_1	743836.AYNA01000090_gene3211	2.41e-26	114.0	COG0683@1|root,COG0683@2|Bacteria,1QFAI@1224|Proteobacteria,2UQ0B@28211|Alphaproteobacteria,36ZNA@31993|Methylocystaceae	28211|Alphaproteobacteria	E	leucine binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_650512_2	981336.F944_02823	1.06e-26	108.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,3NJCC@468|Moraxellaceae	1236|Gammaproteobacteria	D	Rod shape-determining protein MreB	mreB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_1589345_1	880072.Desac_0014	2.36e-87	274.0	COG1219@1|root,COG1219@2|Bacteria,1MWIZ@1224|Proteobacteria,42N1Z@68525|delta/epsilon subdivisions,2WJUS@28221|Deltaproteobacteria,2MR6M@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Belongs to the ClpX chaperone family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
k59_65892_1	1429916.X566_22630	2.71e-56	186.0	COG0656@1|root,COG0656@2|Bacteria,1MWFS@1224|Proteobacteria,2TT2Q@28211|Alphaproteobacteria,3JRGG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Aldo/keto reductase family	yafB	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_946572_1	1304865.JAGF01000001_gene2734	9.28e-114	332.0	COG2945@1|root,COG2945@2|Bacteria,2GP8G@201174|Actinobacteria,4F0VE@85016|Cellulomonadaceae	201174|Actinobacteria	S	hydrolase of the alpha beta	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Abhydrolase_6
k59_1413732_1	349741.Amuc_0337	1.91e-39	143.0	COG0287@1|root,COG0287@2|Bacteria,46SSN@74201|Verrucomicrobia,2IU8S@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
k59_475078_1	1125863.JAFN01000001_gene1001	1.04e-34	135.0	COG0168@1|root,COG0168@2|Bacteria,1N412@1224|Proteobacteria,42MBI@68525|delta/epsilon subdivisions,2WIZ9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Cation transporter	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_709891_1	204669.Acid345_1476	1.03e-42	156.0	COG0477@1|root,COG2814@2|Bacteria,3Y3EB@57723|Acidobacteria,2JIG2@204432|Acidobacteriia	204432|Acidobacteriia	EGP	Fungal trichothecene efflux pump (TRI12)	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
k59_1299807_1	870187.Thini_2251	3.95e-69	221.0	COG0312@1|root,COG0312@2|Bacteria,1NSH6@1224|Proteobacteria,1RR3H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Modulator of DNA gyrase	tldD2	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_1827928_1	977880.RALTA_A0736	1.48e-60	187.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2VSEZ@28216|Betaproteobacteria,1K7M9@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the P(II) protein family	glnB	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
k59_241690_1	556269.ACDQ01000002_gene1102	1.77e-08	61.2	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4733N@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Sigma-54 interaction domain	ntrC	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_888692_1	713586.KB900536_gene1456	1.45e-48	163.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,1RPZ3@1236|Gammaproteobacteria,1WZFI@135613|Chromatiales	135613|Chromatiales	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
k59_1531489_1	68570.DC74_2404	3.7e-08	55.1	COG1612@1|root,COG1612@2|Bacteria,2GJQX@201174|Actinobacteria	201174|Actinobacteria	O	cytochrome oxidase assembly	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
k59_1531489_2	585531.HMPREF0063_11035	5.33e-41	145.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4DNPQ@85009|Propionibacteriales	201174|Actinobacteria	V	daunorubicin resistance ABC transporter	drrA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_767800_1	1122130.AUHN01000006_gene1863	7.94e-45	163.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria	201174|Actinobacteria	D	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_181567_2	1713.JOFV01000009_gene340	5.15e-51	173.0	COG0671@1|root,COG0671@2|Bacteria,2HIXE@201174|Actinobacteria,4F17T@85016|Cellulomonadaceae	201174|Actinobacteria	I	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
k59_475090_1	1208321.D104_10965	5.53e-09	58.2	COG3312@1|root,COG3312@2|Bacteria,1N777@1224|Proteobacteria,1SD0Z@1236|Gammaproteobacteria,1XM4I@135619|Oceanospirillales	135619|Oceanospirillales	C	ATP synthase	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATP-synt_I
k59_1473582_1	1304883.KI912532_gene1960	3.2e-44	154.0	2DB6R@1|root,2Z7I2@2|Bacteria,1R7AG@1224|Proteobacteria,2VQZS@28216|Betaproteobacteria,2KYBI@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_66926_1	1249627.D779_3353	6.12e-80	265.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1238637_1	1123504.JQKD01000023_gene222	4.51e-37	133.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2VQ97@28216|Betaproteobacteria,4ADJ3@80864|Comamonadaceae	28216|Betaproteobacteria	M	PFAM VacJ family lipoprotein	vacJ	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
k59_1766233_1	1279017.AQYJ01000026_gene58	4.24e-55	198.0	COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,1SEWA@1236|Gammaproteobacteria,469S7@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
k59_66933_1	1267005.KB911256_gene1542	3.1e-127	371.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2TR53@28211|Alphaproteobacteria,3N6GW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_1002722_1	585530.HMPREF0183_2225	5.34e-37	126.0	COG4115@1|root,COG4115@2|Bacteria,2IQAJ@201174|Actinobacteria,4FB6F@85019|Brevibacteriaceae	201174|Actinobacteria	S	YoeB-like toxin of bacterial type II toxin-antitoxin system	-	-	-	ko:K19158	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	YoeB_toxin
k59_1002722_2	1122933.JNIY01000003_gene278	1.23e-38	134.0	COG4113@1|root,COG4113@2|Bacteria,2IRMU@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0008150,GO:0009605,GO:0009607,GO:0040008,GO:0043207,GO:0044403,GO:0044419,GO:0045927,GO:0048518,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0065007,GO:0075136	-	-	-	-	-	-	-	-	-	-	PIN
k59_241734_2	870187.Thini_0567	3.34e-186	528.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,4602C@72273|Thiotrichales	1236|Gammaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_49kDa
k59_241734_3	156889.Mmc1_2205	1.42e-44	160.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria	1224|Proteobacteria	C	COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases	bzdV	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4,Fer4_17,Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3
k59_1299864_1	314345.SPV1_08456	1.11e-194	560.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria	1224|Proteobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	-	-	-	-	-	-	-	-	-	-	-	-	XFP,XFP_N
k59_947658_1	391615.ABSJ01000038_gene382	1.17e-63	216.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1J526@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_592591_2	1485544.JQKP01000004_gene537	9.97e-66	225.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,2VMB7@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Major Facilitator	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	MFS_1,TLC
k59_416212_1	391615.ABSJ01000033_gene697	1.24e-112	340.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1J5H2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iSFV_1184.SFV_1868	GAD,tRNA-synt_2,tRNA_anti-codon
k59_709939_2	1249627.D779_0684	6.85e-90	268.0	COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,1WXC6@135613|Chromatiales	135613|Chromatiales	S	integral membrane protein	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
k59_1238665_1	648757.Rvan_2522	3.46e-78	259.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3N7VF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	Protein export membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_360418_3	1415755.JQLV01000002_gene234	5.35e-49	160.0	COG3436@1|root,COG3436@2|Bacteria,1MZFT@1224|Proteobacteria,1SABV@1236|Gammaproteobacteria,1XM0E@135619|Oceanospirillales	135619|Oceanospirillales	L	IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k59_122884_1	880073.Calab_0515	2.15e-71	227.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_241777_1	935839.JAGJ01000002_gene750	1.61e-53	182.0	COG0472@1|root,COG0472@2|Bacteria,2GIT7@201174|Actinobacteria,4F3AQ@85017|Promicromonosporaceae	201174|Actinobacteria	M	Glycosyl transferase family 4	rfe	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
k59_299195_1	1284352.AOIG01000010_gene1992	3.91e-39	146.0	COG3507@1|root,COG3507@2|Bacteria,1TQWA@1239|Firmicutes,4HEPJ@91061|Bacilli,2749U@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 43 family	yxiA3	-	3.2.1.99	ko:K06113	-	-	-	-	ko00000,ko01000	-	GH43	-	GH43_C,Glyco_hydro_43
k59_592602_1	396588.Tgr7_2152	4.3e-51	171.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,1S2U7@1236|Gammaproteobacteria,1WWN0@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_360439_1	340.xcc-b100_4383	1.98e-16	84.0	COG1566@1|root,COG1566@2|Bacteria,1MWG0@1224|Proteobacteria,1RPC8@1236|Gammaproteobacteria,1X5TD@135614|Xanthomonadales	135614|Xanthomonadales	V	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	fusE	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_1355598_1	765913.ThidrDRAFT_2128	2.68e-102	309.0	COG1808@1|root,COG1808@2|Bacteria,1NMS3@1224|Proteobacteria,1RRTC@1236|Gammaproteobacteria,1WWHR@135613|Chromatiales	135613|Chromatiales	I	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
k59_1120128_1	471853.Bcav_2169	3.14e-95	284.0	COG0149@1|root,COG0149@2|Bacteria,2GJXZ@201174|Actinobacteria	201174|Actinobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
k59_475145_1	1120954.ATXE01000001_gene1938	1.24e-59	207.0	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4DNYP@85009|Propionibacteriales	201174|Actinobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_1707847_2	1380354.JIAN01000005_gene1686	9.63e-79	249.0	arCOG05230@1|root,33GXI@2|Bacteria,2ICB0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_533956_2	1304865.JAGF01000001_gene96	2.73e-37	137.0	COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria	201174|Actinobacteria	Q	Belongs to the long-chain O-acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,PAP2_3,WES_acyltransf
k59_1002767_2	83332.Rv2642	1.94e-14	69.7	COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria,23A4J@1762|Mycobacteriaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
k59_827130_2	472759.Nhal_0327	3.78e-65	217.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1WWBU@135613|Chromatiales	135613|Chromatiales	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_416267_1	177437.HRM2_40340	2.04e-37	142.0	COG4191@1|root,COG4191@2|Bacteria,1R7KQ@1224|Proteobacteria,42PAP@68525|delta/epsilon subdivisions,2WITB@28221|Deltaproteobacteria,2MHP3@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,dCache_1
k59_1473690_2	1333998.M2A_0825	5.68e-162	464.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2TS83@28211|Alphaproteobacteria,4BPBI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_947745_1	1079460.ATTQ01000001_gene5860	1.4e-22	103.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,4B81Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
k59_1828074_2	1045009.AFXQ01000011_gene475	6.76e-29	112.0	COG1120@1|root,COG1120@2|Bacteria,2I5PA@201174|Actinobacteria,1WCNF@1268|Micrococcaceae	201174|Actinobacteria	HP	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_1828074_3	935866.JAER01000005_gene229	2.63e-34	122.0	COG0735@1|root,COG0735@2|Bacteria,2IKS3@201174|Actinobacteria,4DQZK@85009|Propionibacteriales	201174|Actinobacteria	P	Belongs to the Fur family	furB	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010035,GO:0010038,GO:0010043,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_1590082_1	391038.Bphy_3526	2.52e-107	338.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2W0DK@28216|Betaproteobacteria,1K5G0@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.2.3	ko:K07812	-	-	-	-	ko00000,ko01000,ko02000	5.A.3.4	-	-	Molybdopterin,Molydop_binding
k59_8000_1	997884.HMPREF1068_03852	4.7e-107	319.0	COG1219@1|root,COG1219@2|Bacteria,4NE1B@976|Bacteroidetes,2FMQV@200643|Bacteroidia,4ANSV@815|Bacteroidaceae	976|Bacteroidetes	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_767878_1	1163617.SCD_n02036	1.67e-20	89.0	2AE70@1|root,3140Y@2|Bacteria,1RK0Q@1224|Proteobacteria,2VSEF@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1062746_1	1120983.KB894571_gene2250	6.07e-106	314.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,1JPZ9@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_8004_1	425104.Ssed_0189	1.36e-13	70.9	COG1999@1|root,COG1999@2|Bacteria,1RHSV@1224|Proteobacteria,1S6HW@1236|Gammaproteobacteria,2QBR2@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Electron transport protein SCO1 SenC	scoP	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
k59_8004_2	498211.CJA_3140	3.26e-06	50.1	COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,1RN1U@1236|Gammaproteobacteria,1FGE0@10|Cellvibrio	1236|Gammaproteobacteria	I	Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
k59_299249_2	313596.RB2501_08685	9.84e-27	109.0	COG0078@1|root,COG0078@2|Bacteria,4NEYX@976|Bacteroidetes,1HYDI@117743|Flavobacteriia	976|Bacteroidetes	E	Belongs to the ATCase OTCase family	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.11,2.1.3.9	ko:K09065,ko:K13043	ko00220,ko01100,ko01230,map00220,map01100,map01230	M00845	R07245,R08937	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_1002793_1	96561.Dole_0650	2.68e-90	286.0	COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,42NCP@68525|delta/epsilon subdivisions,2WJSM@28221|Deltaproteobacteria,2MI5K@213118|Desulfobacterales	28221|Deltaproteobacteria	M	HAD-superfamily hydrolase, subfamily IIB	-	-	2.4.1.14	ko:K00696	ko00500,ko01100,map00500,map01100	-	R00766	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth
k59_651392_1	572477.Alvin_1834	2.77e-56	181.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,1RN1J@1236|Gammaproteobacteria,1WWMS@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
k59_651392_2	259536.Psyc_1182	5.05e-08	52.4	COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,1S9B2@1236|Gammaproteobacteria,3NNI7@468|Moraxellaceae	1236|Gammaproteobacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	GO:0003674,GO:0003824,GO:0004150,GO:0005488,GO:0005515,GO:0016829,GO:0016830,GO:0016832,GO:0042802	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	iECDH1ME8569_1439.ECDH1ME8569_2955,iECSE_1348.ECSE_3338,iPC815.YPO0648,iSBO_1134.SBO_2914,iSDY_1059.SDY_3241,iSFxv_1172.SFxv_3403,iUTI89_1310.UTI89_C3494,iYL1228.KPN_03462,ic_1306.c3808	FolB
k59_827174_1	663610.JQKO01000010_gene2249	1.71e-56	187.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2TRRT@28211|Alphaproteobacteria,3NADA@45404|Beijerinckiaceae	28211|Alphaproteobacteria	M	Glycosyltransferase like family 2	MA20_05865	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
k59_1596589_2	550540.Fbal_0245	1.01e-24	98.2	COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,1S3PA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
k59_1248348_1	102125.Xen7305DRAFT_00028620	3.46e-109	329.0	COG3547@1|root,COG3547@2|Bacteria,1G077@1117|Cyanobacteria,3VNMH@52604|Pleurocapsales	1117|Cyanobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_130083_1	1449076.JOOE01000001_gene1634	3.79e-19	90.5	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2TSM0@28211|Alphaproteobacteria,2K0FR@204457|Sphingomonadales	204457|Sphingomonadales	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_1421826_1	631362.Thi970DRAFT_02353	1.02e-23	94.7	COG2166@1|root,COG2166@2|Bacteria,1RI8F@1224|Proteobacteria,1S65C@1236|Gammaproteobacteria,1WY7Q@135613|Chromatiales	135613|Chromatiales	S	PFAM Fe-S metabolism associated	-	-	-	ko:K02426	-	-	-	-	ko00000	-	-	-	SufE
k59_423038_1	1049564.TevJSym_af00570	7.47e-64	211.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1J523@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase	ilvI	GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1907,iB21_1397.B21_00078,iBWG_1329.BWG_0073,iECBD_1354.ECBD_3539,iECB_1328.ECB_00079,iECD_1391.ECD_00079,iUTI89_1310.UTI89_C0085,iYL1228.KPN_00082	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_305594_1	317619.ANKN01000027_gene1727	5.17e-11	68.2	COG0860@1|root,COG0860@2|Bacteria,1G2V1@1117|Cyanobacteria	1117|Cyanobacteria	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,DUF3747
k59_1008351_1	1229204.AMYY01000001_gene2865	3.19e-34	127.0	2DPQ0@1|root,332XN@2|Bacteria,1R3DX@1224|Proteobacteria,2UHFZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1186865_1	631362.Thi970DRAFT_04623	1.23e-90	275.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1WXAD@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_369897_1	713586.KB900536_gene1920	3.72e-22	94.7	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,1X257@135613|Chromatiales	135613|Chromatiales	P	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
k59_369897_2	765911.Thivi_2775	2.22e-26	104.0	2AE70@1|root,3140Y@2|Bacteria,1RK0Q@1224|Proteobacteria,1S6JU@1236|Gammaproteobacteria,1WYRY@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_76381_1	394221.Mmar10_0351	8.72e-87	274.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,43Z43@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	pyruvate flavodoxin ferredoxin oxidoreductase	MA20_01045	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_481807_1	316067.Geob_2758	3.73e-73	232.0	COG0668@1|root,COG0668@2|Bacteria,1MW7V@1224|Proteobacteria,42R90@68525|delta/epsilon subdivisions,2WMUJ@28221|Deltaproteobacteria,43SZC@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	mscS-2	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_1125893_1	511062.GU3_01305	6.32e-93	283.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1Y3T2@135624|Aeromonadales	135624|Aeromonadales	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_423050_2	396588.Tgr7_2912	2.19e-73	224.0	COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,1S6WA@1236|Gammaproteobacteria,1WXPI@135613|Chromatiales	135613|Chromatiales	F	phosphoribosyltransferase	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
k59_717037_1	497964.CfE428DRAFT_3157	3.17e-39	140.0	COG0344@1|root,COG0344@2|Bacteria,46VTA@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
k59_1483432_1	644282.Deba_1553	9.59e-54	181.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P8Q@68525|delta/epsilon subdivisions,2WK2B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Response regulator, receiver	-	-	-	ko:K11384	ko02020,map02020	M00505	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1483432_2	1121405.dsmv_1133	7.26e-25	102.0	COG5002@1|root,COG5002@2|Bacteria,1R6WE@1224|Proteobacteria,42P99@68525|delta/epsilon subdivisions,2WK5E@28221|Deltaproteobacteria,2MPS4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K11383	ko02020,map02020	M00505	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	4HB_MCP_1,HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8
k59_1421849_1	1298867.AUES01000016_gene3879	9.83e-77	259.0	COG2203@1|root,COG4191@1|root,COG5002@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3K6MV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,dCache_1
k59_898175_1	1123251.ATWM01000004_gene1894	6.8e-33	128.0	COG1653@1|root,COG1653@2|Bacteria,2GJXB@201174|Actinobacteria,4FG1W@85021|Intrasporangiaceae	201174|Actinobacteria	G	Sugar ABC transporter substrate-binding protein	-	-	-	ko:K10232	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1,SBP_bac_8
k59_76406_1	472759.Nhal_1431	2.55e-96	296.0	COG1012@1|root,COG1012@2|Bacteria,1MW72@1224|Proteobacteria,1RY9G@1236|Gammaproteobacteria,1X2DF@135613|Chromatiales	135613|Chromatiales	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1186889_1	388051.AUFE01000039_gene4135	5.41e-64	206.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2VHDY@28216|Betaproteobacteria,1K3NA@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NADH flavin oxidoreductase NADH oxidase	namA	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN
k59_369933_1	1049564.TevJSym_as00150	5.72e-78	253.0	COG0586@1|root,COG0586@2|Bacteria,1R0F3@1224|Proteobacteria,1RPDS@1236|Gammaproteobacteria,1JAB5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Acid phosphatase homologues	lssY	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	LssY_C,PAP2,SNARE_assoc
k59_1008374_1	235985.BBPN01000012_gene6826	2.36e-57	189.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,2NHTD@228398|Streptacidiphilus	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
k59_1538228_1	1136177.KCA1_2201	1.68e-20	97.1	COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,4HA64@91061|Bacilli,3F3Z0@33958|Lactobacillaceae	91061|Bacilli	L	ATP-dependent helicase nuclease subunit A	addA	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1596629_1	1294273.roselon_03250	1.51e-170	480.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_1309337_1	1384054.N790_02970	3.2e-17	80.9	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1X4T1@135614|Xanthomonadales	135614|Xanthomonadales	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_188796_1	105559.Nwat_3100	1.18e-20	87.8	COG5488@1|root,COG5488@2|Bacteria,1N9B7@1224|Proteobacteria,1SF1J@1236|Gammaproteobacteria,1X1FG@135613|Chromatiales	135613|Chromatiales	S	Integral membrane protein (DUF2244)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2244
k59_76421_1	1209072.ALBT01000058_gene919	7.1e-38	138.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria,1FGRX@10|Cellvibrio	1236|Gammaproteobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008033,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016070,GO:0016740,GO:0016765,GO:0019222,GO:0031323,GO:0031326,GO:0032268,GO:0033554,GO:0034248,GO:0034470,GO:0034605,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043555,GO:0044237,GO:0044238,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0051716,GO:0052381,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990497,GO:2000112,GO:2000765	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
k59_1073216_1	1121456.ATVA01000017_gene50	2.17e-71	234.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MIZ@68525|delta/epsilon subdivisions,2WIUX@28221|Deltaproteobacteria,2M8XD@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	CHASE5,HAMP,HATPase_c,HisKA,dCache_1,dCache_2
k59_773464_1	96561.Dole_1579	7.43e-82	251.0	COG0177@1|root,COG0177@2|Bacteria,1RAK3@1224|Proteobacteria,42M4V@68525|delta/epsilon subdivisions,2WPRX@28221|Deltaproteobacteria,2MJJR@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Protein of unknown function (DUF2400)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2400
k59_540670_1	713587.THITH_12235	7.49e-06	44.7	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	VY92_02980	-	1.11.1.15	ko:K03386,ko:K03676	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Glutaredoxin,Redoxin
k59_540670_2	2340.JV46_08070	3.97e-131	387.0	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,1RMC0@1236|Gammaproteobacteria,1J54W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	gor	GO:0000166,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071949,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	iZ_1308.Z4900	Pyr_redox_2,Pyr_redox_dim
k59_1772663_1	383372.Rcas_4246	3.97e-90	289.0	COG0366@1|root,COG0366@2|Bacteria,2G5NW@200795|Chloroflexi,376G5@32061|Chloroflexia	32061|Chloroflexia	G	SMART alpha amylase, catalytic sub domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
k59_188803_1	391615.ABSJ01000022_gene318	5.02e-28	112.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1J4EU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604	PBP_dimer,Transpeptidase
k59_188803_2	1286106.MPL1_05409	5.9e-74	236.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,460BS@72273|Thiotrichales	72273|Thiotrichales	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_1309358_1	471852.Tcur_1186	0.000262	48.1	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4EFVQ@85012|Streptosporangiales	201174|Actinobacteria	O	Trypsin-like peptidase domain	sprI	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
k59_188804_1	1026882.MAMP_00712	4.54e-81	260.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,45ZU0@72273|Thiotrichales	72273|Thiotrichales	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_20915_2	468556.AQYG01000041_gene3536	5e-09	58.9	COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria,4GDUH@85026|Gordoniaceae	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1772671_1	469596.HMPREF9488_03041	2.62e-37	140.0	COG0561@1|root,COG0561@2|Bacteria,1V40R@1239|Firmicutes,3VQJD@526524|Erysipelotrichia	526524|Erysipelotrichia	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
k59_369977_1	471853.Bcav_2924	5.91e-84	264.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_369977_2	471853.Bcav_2922	2.56e-60	191.0	COG4122@1|root,COG4122@2|Bacteria,2GPEV@201174|Actinobacteria	201174|Actinobacteria	S	o-methyltransferase	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Methyltransf_24,Methyltransf_3
k59_76452_1	880072.Desac_1776	1.57e-16	74.7	COG2204@1|root,COG2204@2|Bacteria,1RHEG@1224|Proteobacteria,42UQT@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_76452_2	880072.Desac_1775	1.21e-53	171.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_898230_1	1123274.KB899419_gene2003	1.9e-73	228.0	COG0834@1|root,COG0834@2|Bacteria,2J78W@203691|Spirochaetes	203691|Spirochaetes	ET	COGs COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_130157_1	1120944.JONS01000016_gene1162	1.2e-05	47.8	COG0455@1|root,COG0455@2|Bacteria,2IARP@201174|Actinobacteria,4D3TS@85005|Actinomycetales	201174|Actinobacteria	D	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
k59_130157_2	935839.JAGJ01000002_gene784	2.39e-50	170.0	COG1261@1|root,COG1261@2|Bacteria,2GR8T@201174|Actinobacteria,4F4IS@85017|Promicromonosporaceae	201174|Actinobacteria	NO	PFAM SAF domain	-	-	-	-	-	-	-	-	-	-	-	-	ChapFlgA,SAF
k59_130157_3	396014.BF93_01650	1.23e-21	86.7	COG3311@1|root,COG3311@2|Bacteria,2GR98@201174|Actinobacteria,4FD72@85020|Dermabacteraceae	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
k59_188825_1	196162.Noca_1001	1.02e-78	250.0	COG1236@1|root,COG1236@2|Bacteria,2HEXB@201174|Actinobacteria,4DQ4R@85009|Propionibacteriales	201174|Actinobacteria	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL
k59_834265_1	96561.Dole_1461	1.22e-123	371.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MINQ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
k59_254497_1	1304865.JAGF01000001_gene1952	2.82e-57	191.0	COG1073@1|root,COG1073@2|Bacteria,2I64G@201174|Actinobacteria,4F1AN@85016|Cellulomonadaceae	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
k59_254497_2	134676.ACPL_7040	3.45e-21	89.7	COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,4DCFF@85008|Micromonosporales	201174|Actinobacteria	GK	ROK family	ppgK	-	2.7.1.2,2.7.1.63	ko:K00845,ko:K00886	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786,R02187,R02189	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_1596668_1	713586.KB900536_gene2955	2.12e-102	313.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1WX8Q@135613|Chromatiales	135613|Chromatiales	M	Cell wall hydrolase autolysin	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,LysM
k59_1187751_2	572477.Alvin_0016	8.27e-32	114.0	2EQBS@1|root,33HXW@2|Bacteria,1MZT8@1224|Proteobacteria,1SC31@1236|Gammaproteobacteria,1WYX4@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF3240)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3240
k59_1187751_3	1267005.KB911257_gene1161	5.56e-42	154.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
k59_189658_1	1232410.KI421426_gene1368	1.88e-48	168.0	COG4313@1|root,COG4313@2|Bacteria,1R58D@1224|Proteobacteria,42SAW@68525|delta/epsilon subdivisions,2WP5F@28221|Deltaproteobacteria,43VV8@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
k59_1074826_2	870187.Thini_1248	7.56e-71	235.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,4603Y@72273|Thiotrichales	72273|Thiotrichales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	napA	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_371121_1	1453501.JELR01000001_gene3093	1.18e-41	158.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RNWM@1236|Gammaproteobacteria,465X0@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	exporters of the RND superfamily	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_1657540_1	1260251.SPISAL_01820	5.85e-19	90.9	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,1RNP1@1236|Gammaproteobacteria,1WWFF@135613|Chromatiales	135613|Chromatiales	V	ABC-type transport system, involved in lipoprotein release, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1249635_1	1123242.JH636434_gene3243	1.42e-38	137.0	COG3247@1|root,COG3247@2|Bacteria,2J0TA@203682|Planctomycetes	203682|Planctomycetes	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
k59_131041_2	748247.AZKH_3137	1.1e-26	103.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2VJ2N@28216|Betaproteobacteria,2KVGG@206389|Rhodocyclales	206389|Rhodocyclales	S	synthesis repressor, PhaR	-	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
k59_958407_2	399739.Pmen_2311	1.95e-39	144.0	COG0577@1|root,COG0577@2|Bacteria,1QRYR@1224|Proteobacteria,1S0ZU@1236|Gammaproteobacteria,1YG9Q@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	V	FtsX-like permease family	tagS	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_189673_1	411154.GFO_1210	8.76e-10	58.9	2DC8J@1|root,2ZD97@2|Bacteria,4NVZ2@976|Bacteroidetes,1I1QZ@117743|Flavobacteriia	976|Bacteroidetes	S	SpoIIAA-like	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
k59_1310566_1	929558.SMGD1_2565	9.03e-24	105.0	COG2433@1|root,COG2433@2|Bacteria,1QW3W@1224|Proteobacteria,42RB0@68525|delta/epsilon subdivisions,2YNE9@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Pfam Transposase IS66	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
k59_1539160_1	1101189.AQUO01000002_gene424	5.07e-26	102.0	COG5012@1|root,COG5012@2|Bacteria,1RDEU@1224|Proteobacteria,2TVXN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	cobalamin binding protein	mtbC	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
k59_659353_2	519989.ECTPHS_10531	1.86e-47	164.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1WVZB@135613|Chromatiales	135613|Chromatiales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_1249651_1	883126.HMPREF9710_03332	1.46e-85	261.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,2VI08@28216|Betaproteobacteria,473TX@75682|Oxalobacteraceae	28216|Betaproteobacteria	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
k59_1187779_1	378753.KRH_17960	9.13e-29	112.0	COG0180@1|root,COG0180@2|Bacteria,2GJ9A@201174|Actinobacteria,1W811@1268|Micrococcaceae	201174|Actinobacteria	J	Tryptophanyl-tRNA synthetase	trpS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_1187779_2	644968.DFW101_1840	9.16e-09	58.9	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,42N97@68525|delta/epsilon subdivisions,2WKVE@28221|Deltaproteobacteria,2M7ZJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Transporter-associated region	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_77590_1	1121012.AUKX01000002_gene3413	1.65e-153	443.0	COG2801@1|root,COG2801@2|Bacteria,4NHJD@976|Bacteroidetes,1IABF@117743|Flavobacteriia	976|Bacteroidetes	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve,rve_3
k59_774174_1	1122214.AQWH01000009_gene2066	1.1e-44	149.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,2U79E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Peptidyl-prolyl cis-trans	slyD	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
k59_189684_2	2340.JV46_10170	4.3e-70	220.0	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,1J545@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex	ccoP	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	iJN746.PP_4253	Cytochrome_CBB3,FixP_N
k59_1484668_1	643562.Daes_0198	7.39e-07	56.2	COG1266@1|root,COG1266@2|Bacteria,1Q05Q@1224|Proteobacteria,436DR@68525|delta/epsilon subdivisions,2X0Z2@28221|Deltaproteobacteria,2MDTP@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_255637_1	1227261.HMPREF0043_01810	3.47e-61	199.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4D395@85005|Actinomycetales	201174|Actinobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.90	ko:K00895	ko00010,ko00030,ko00051,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map01100,map01110,map01120,map01130	-	R00764,R02073	RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_1009121_2	1121106.JQKB01000092_gene4143	2.18e-14	73.6	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1249674_1	765913.ThidrDRAFT_1741	1.3e-51	163.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,1S5VT@1236|Gammaproteobacteria,1WYHJ@135613|Chromatiales	135613|Chromatiales	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_1838809_1	1123368.AUIS01000032_gene1394	1.16e-71	231.0	COG1080@1|root,COG1080@2|Bacteria	2|Bacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_776106_3	497321.C664_16540	7.25e-57	181.0	COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,2VQ6X@28216|Betaproteobacteria,2KW4E@206389|Rhodocyclales	206389|Rhodocyclales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
k59_258585_1	1121479.AUBS01000001_gene3277	2.52e-137	408.0	COG1680@1|root,COG1680@2|Bacteria,1MVZN@1224|Proteobacteria	1224|Proteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
k59_776111_1	1172562.HCN_0476	2.22e-20	95.1	COG4866@1|root,COG4866@2|Bacteria,1RIUZ@1224|Proteobacteria,42P4H@68525|delta/epsilon subdivisions,2YM84@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Uncharacterised conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
k59_308975_1	768671.ThimaDRAFT_4090	1.07e-128	372.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,1WWWY@135613|Chromatiales	135613|Chromatiales	D	Belongs to the TtcA family	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
k59_1717517_1	395493.BegalDRAFT_0856	1.9e-17	81.6	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,45ZNE@72273|Thiotrichales	72273|Thiotrichales	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
k59_1717517_2	1122599.AUGR01000017_gene2989	5.36e-13	71.6	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1XHR4@135619|Oceanospirillales	135619|Oceanospirillales	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_902880_1	1049564.TevJSym_av00160	1.64e-153	447.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,1RQ7G@1236|Gammaproteobacteria,1J4EK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	COG0008 Glutamyl- and glutaminyl-tRNA synthetases	glnS	GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECIAI39_1322.ECIAI39_0637	tRNA-synt_1c,tRNA-synt_1c_C
k59_192151_2	999549.KI421513_gene3335	1.66e-24	96.3	COG2346@1|root,COG2346@2|Bacteria,1Q6XS@1224|Proteobacteria,2VD19@28211|Alphaproteobacteria,281IP@191028|Leisingera	28211|Alphaproteobacteria	S	Bacterial-like globin	-	-	-	-	-	-	-	-	-	-	-	-	Bac_globin
k59_1717524_1	1120985.AUMI01000011_gene333	1.15e-05	52.4	COG0667@1|root,COG0667@2|Bacteria,1V53W@1239|Firmicutes	1239|Firmicutes	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1775994_1	1454010.JEOE01000005_gene1665	8.43e-283	814.0	COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,2GKXQ@201174|Actinobacteria,4F1SJ@85016|Cellulomonadaceae	201174|Actinobacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
k59_374667_1	1045855.DSC_08435	7.11e-54	194.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1X46R@135614|Xanthomonadales	135614|Xanthomonadales	E	glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH,GDH_N
k59_1314062_1	331869.BAL199_13463	1.92e-55	186.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TQYV@28211|Alphaproteobacteria,4BPJ8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabB	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1314062_2	913325.N799_13235	9.11e-05	43.5	COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,1RP6W@1236|Gammaproteobacteria,1X5SK@135614|Xanthomonadales	135614|Xanthomonadales	I	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length	fabA	-	4.2.1.59,5.3.3.14	ko:K01716	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639	RC00831,RC01078,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
k59_1078444_1	367299.JOEE01000008_gene454	7.02e-101	313.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4FEP0@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA ligase	ligD	-	-	-	-	-	-	-	-	-	-	-	DNA_primase_S
k59_24872_1	1216007.AOPM01000002_gene2539	2.49e-217	618.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,2Q0DP@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tktA	GO:0000302,GO:0003674,GO:0003824,GO:0004802,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009635,GO:0009636,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016740,GO:0016744,GO:0019219,GO:0019222,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0019842,GO:0030145,GO:0030976,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0036245,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046496,GO:0046677,GO:0046872,GO:0046914,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051156,GO:0051171,GO:0051173,GO:0051186,GO:0051252,GO:0051254,GO:0051716,GO:0055086,GO:0060255,GO:0065007,GO:0070301,GO:0070887,GO:0071236,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0072524,GO:0072747,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:1901135,GO:1901322,GO:1901360,GO:1901363,GO:1901562,GO:1901564,GO:1901654,GO:1901655,GO:1901681,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	iECABU_c1320.ECABU_c27750,iLF82_1304.LF82_2271,iNRG857_1313.NRG857_12300,iSDY_1059.SDY_3141,iYL1228.KPN_01127,iYL1228.KPN_02799,ic_1306.c2990	Transket_pyr,Transketolase_C,Transketolase_N
k59_1252591_1	1123322.KB904647_gene1774	1.22e-67	229.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria	201174|Actinobacteria	E	Methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_1488418_1	446469.Sked_10400	4.35e-163	482.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.196,3.2.1.68	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02111,R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_721140_1	446466.Cfla_2705	1.03e-115	352.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4F0X8@85016|Cellulomonadaceae	201174|Actinobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_427031_2	1278307.KB907040_gene1962	6.71e-30	109.0	COG1550@1|root,COG1550@2|Bacteria,1NGDU@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
k59_1190962_1	519989.ECTPHS_14046	1.04e-37	139.0	COG2801@1|root,COG2801@2|Bacteria,1R6TH@1224|Proteobacteria,1RRWS@1236|Gammaproteobacteria,1X2I8@135613|Chromatiales	135613|Chromatiales	L	Mu transposase, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,Mu-transpos_C,rve
k59_1718248_1	367299.JOEE01000001_gene2018	2.8e-96	288.0	COG0181@1|root,COG0181@2|Bacteria,2GMWI@201174|Actinobacteria,4FE32@85021|Intrasporangiaceae	201174|Actinobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0510	Porphobil_deam,Porphobil_deamC
k59_1425947_1	1267005.KB911257_gene1101	2e-89	283.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2TQTQ@28211|Alphaproteobacteria,3N6EP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C
k59_192890_1	1089553.Tph_c24730	3.11e-30	118.0	COG0169@1|root,COG0169@2|Bacteria,1UIG1@1239|Firmicutes,24GDF@186801|Clostridia	186801|Clostridia	E	TIGRFAM pyrrolysine biosynthesis protein PylD	-	-	-	ko:K16182	ko00300,ko01120,map00300,map01120	-	R10012	RC00062	ko00000,ko00001	-	-	-	NAD_binding_7
k59_962948_1	1034943.BN1094_02594	3.85e-97	295.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1JD94@118969|Legionellales	118969|Legionellales	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_1488448_1	1144305.PMI02_00107	1.91e-11	67.8	COG0625@1|root,COG0625@2|Bacteria,1RA05@1224|Proteobacteria,2TS58@28211|Alphaproteobacteria,2K1M0@204457|Sphingomonadales	204457|Sphingomonadales	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
k59_427047_1	1049564.TevJSym_ad00310	3.27e-72	231.0	2E6HP@1|root,3314Y@2|Bacteria,1QGPJ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_309724_1	1304874.JAFY01000002_gene169	1.67e-26	108.0	COG0500@1|root,COG2226@2|Bacteria,3TAMQ@508458|Synergistetes	508458|Synergistetes	Q	PFAM methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
k59_1776744_1	640081.Dsui_3457	4.31e-63	212.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,2KUQJ@206389|Rhodocyclales	206389|Rhodocyclales	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_962963_1	1124983.PFLCHA0_c07120	7.1e-18	81.6	COG3238@1|root,COG3238@2|Bacteria,1N6ZC@1224|Proteobacteria,1S9V7@1236|Gammaproteobacteria,1YTN4@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Putative inner membrane exporter, YdcZ	-	-	-	ko:K09936	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.7.21	-	-	DMT_YdcZ
k59_962963_2	1161401.ASJA01000001_gene481	7.9e-18	83.6	COG4206@1|root,COG4206@2|Bacteria,1QUGQ@1224|Proteobacteria,2TXTZ@28211|Alphaproteobacteria,440TH@69657|Hyphomonadaceae	28211|Alphaproteobacteria	H	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_776740_1	1123267.JONN01000001_gene2072	1.33e-45	162.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,2K0PZ@204457|Sphingomonadales	204457|Sphingomonadales	E	gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1366417_2	471853.Bcav_2100	9.88e-47	156.0	COG1259@1|root,COG1259@2|Bacteria,2GN26@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Uncharacterised ACR, COG1259	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
k59_1425964_1	1122237.AUGQ01000005_gene1252	2.62e-58	195.0	COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria,4FKYI@85023|Microbacteriaceae	201174|Actinobacteria	Q	NAD(P)-binding Rossmann-like domain	p	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
k59_1600655_1	269799.Gmet_3281	2.48e-82	251.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42QX7@68525|delta/epsilon subdivisions,2WNUD@28221|Deltaproteobacteria,43UWH@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	PhoH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_962968_1	247634.GPB2148_3397	4.7e-08	56.2	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1RMVU@1236|Gammaproteobacteria,1J61R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1454 Alcohol dehydrogenase, class IV	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
k59_82176_2	1170562.Cal6303_3691	5.13e-16	74.7	COG1186@1|root,COG1186@2|Bacteria,1G5Y2@1117|Cyanobacteria,1HNFX@1161|Nostocales	1117|Cyanobacteria	J	Protein chain release factor B	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
k59_721167_1	1230342.CTM_03975	2.54e-19	89.4	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,36DIR@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
k59_721167_2	1267535.KB906767_gene4475	5.22e-53	191.0	COG3011@1|root,COG3011@2|Bacteria	2|Bacteria	CH	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF393,LMF1
k59_1776754_1	1194972.MVAC_29123	4.03e-05	48.1	COG2267@1|root,COG2267@2|Bacteria,2GNQI@201174|Actinobacteria,236RT@1762|Mycobacteriaceae	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_544499_1	1262915.BN574_00007	8.41e-54	186.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4H31W@909932|Negativicutes	909932|Negativicutes	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_259777_1	1184609.KILIM_090_00030	1.67e-45	167.0	COG4907@1|root,COG4907@2|Bacteria,2GNW7@201174|Actinobacteria	201174|Actinobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
k59_1600658_1	1385518.N798_01355	4.69e-44	148.0	COG2032@1|root,COG2032@2|Bacteria	2|Bacteria	P	superoxide dismutase activity	sodC	-	1.15.1.1	ko:K02674,ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	-	-	-	Sod_Cu
k59_602971_1	204669.Acid345_2204	8.56e-34	125.0	COG0705@1|root,COG0705@2|Bacteria,3Y5A9@57723|Acidobacteria,2JNBE@204432|Acidobacteriia	204432|Acidobacteriia	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
k59_1011720_1	593907.Celgi_1599	8.45e-43	158.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4F0QU@85016|Cellulomonadaceae	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
k59_1660863_1	590998.Celf_1610	2.56e-52	186.0	COG0768@1|root,COG0768@2|Bacteria,2GKHH@201174|Actinobacteria,4F0VT@85016|Cellulomonadaceae	201174|Actinobacteria	M	Penicillin-binding Protein dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
k59_427072_1	378806.STAUR_0742	4.71e-52	174.0	COG0500@1|root,COG2226@2|Bacteria,1RFPW@1224|Proteobacteria	1224|Proteobacteria	Q	Methyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_662553_1	883.DvMF_2901	7.7e-07	57.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42M55@68525|delta/epsilon subdivisions,2WIKM@28221|Deltaproteobacteria,2M9K5@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
k59_904027_1	2340.JV46_18550	3.68e-36	134.0	COG2995@1|root,COG2995@2|Bacteria,1RAF7@1224|Proteobacteria,1S0MG@1236|Gammaproteobacteria,1JBDX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Paraquat-inducible protein A	-	-	-	-	-	-	-	-	-	-	-	-	PqiA
k59_1542376_1	1122180.Lokhon_01016	0.000207	48.9	COG0596@1|root,COG0596@2|Bacteria,1MVVX@1224|Proteobacteria,2TT0S@28211|Alphaproteobacteria,2P8KP@245186|Loktanella	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1776773_1	292415.Tbd_1126	1.51e-35	123.0	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
k59_1488497_1	1049564.TevJSym_aq00330	5.86e-15	78.6	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,1RPH9@1236|Gammaproteobacteria,1J4D7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	COG1305 Transglutaminase-like enzymes	tgpA	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
k59_1488497_2	631362.Thi970DRAFT_03647	4.38e-19	86.3	COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,1WWD0@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_1718293_1	1219072.VHA01S_010_00280	1.13e-16	78.2	COG0784@1|root,COG0784@2|Bacteria,1MYIP@1224|Proteobacteria,1S89X@1236|Gammaproteobacteria,1XWV8@135623|Vibrionales	135623|Vibrionales	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_1718293_2	645127.ckrop_1749	1.61e-26	110.0	COG1835@1|root,COG2755@1|root,COG1835@2|Bacteria,COG2755@2|Bacteria,2GKI5@201174|Actinobacteria,22JW6@1653|Corynebacteriaceae	201174|Actinobacteria	I	acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3,Lipase_GDSL_2
k59_1191015_1	240016.ABIZ01000001_gene5347	7.95e-51	176.0	COG1596@1|root,COG1596@2|Bacteria,46XCW@74201|Verrucomicrobia,2IVGU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Polysaccharide biosynthesis/export protein	-	-	-	-	-	-	-	-	-	-	-	-	Poly_export,SLBB
k59_1843374_1	1231185.BAMP01000085_gene3572	7.49e-28	105.0	COG2154@1|root,COG2154@2|Bacteria,1MZ5Q@1224|Proteobacteria,2UBWN@28211|Alphaproteobacteria,43KWX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	pterin-4-alpha-carbinolamine dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
k59_1843374_2	425104.Ssed_2704	1.53e-17	81.6	COG1184@1|root,COG1184@2|Bacteria	2|Bacteria	J	translation initiation factor activity	-	-	-	ko:K03680	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	IF-2B
k59_1843380_1	1304275.C41B8_02807	3.71e-90	279.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_1366451_1	367299.JOEE01000004_gene1220	4.33e-99	295.0	COG3393@1|root,COG3393@2|Bacteria,2GMD2@201174|Actinobacteria,4FFWK@85021|Intrasporangiaceae	201174|Actinobacteria	S	Acetyltransferase	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,DUF4081,FR47
k59_134291_2	768671.ThimaDRAFT_1126	2.71e-96	296.0	COG2170@1|root,COG2170@2|Bacteria,1MXET@1224|Proteobacteria,1RPKZ@1236|Gammaproteobacteria,1WWXK@135613|Chromatiales	135613|Chromatiales	S	glutamate--cysteine ligase	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
k59_1011743_1	285535.JOEY01000083_gene9603	5.71e-06	49.3	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.17.1.9,1.6.5.3	ko:K00122,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_1011743_2	40571.JOEA01000014_gene1675	5.71e-34	130.0	COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4DZUH@85010|Pseudonocardiales	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdnG	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
k59_776771_1	2340.JV46_09960	2.52e-162	466.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1J4I6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	JKL	DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlE	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_544532_1	1122194.AUHU01000017_gene1796	3.58e-92	273.0	COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,1RP6W@1236|Gammaproteobacteria,4657R@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length	fabA	-	4.2.1.59,5.3.3.14	ko:K01716	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639	RC00831,RC01078,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
k59_544532_2	1205680.CAKO01000040_gene480	6.22e-25	102.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TQYV@28211|Alphaproteobacteria,2JPU4@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1843392_1	1151061.CAJY01000038_gene3458	1.57e-34	133.0	COG1403@1|root,COG1403@2|Bacteria,2I9AH@201174|Actinobacteria	201174|Actinobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_1843392_2	590998.Celf_1910	1.72e-15	71.2	COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
k59_1600684_1	765911.Thivi_4098	1.06e-35	125.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria,1WY5P@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
k59_1600684_2	322710.Avin_12680	2.53e-64	204.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	maF-like protein	yhdE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_1600684_3	1049564.TevJSym_ak00680	2.15e-244	684.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1J5GF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	COG1530 Ribonucleases G and E	rng	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_1718318_1	765913.ThidrDRAFT_4183	2.01e-57	194.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1WW7K@135613|Chromatiales	135613|Chromatiales	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_662585_1	768671.ThimaDRAFT_1909	2.63e-75	231.0	COG2062@1|root,COG2062@2|Bacteria,1QMZ8@1224|Proteobacteria,1TKAS@1236|Gammaproteobacteria,1X1BB@135613|Chromatiales	135613|Chromatiales	T	Histidine phosphatase superfamily (branch 1)	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_259859_1	358823.DF19_12210	6.75e-12	67.0	COG1840@1|root,COG1840@2|Bacteria	2|Bacteria	P	iron ion homeostasis	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
k59_776779_1	316057.RPD_4216	5.37e-78	251.0	COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2TSHG@28211|Alphaproteobacteria,3K09N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
k59_1106096_1	1123393.KB891316_gene1613	9.01e-22	100.0	2C1AX@1|root,33GUX@2|Bacteria,1MZSH@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_450260_1	269800.Tfu_0118	6.49e-23	95.5	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,4EG20@85012|Streptosporangiales	201174|Actinobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_450260_2	1123065.ATWL01000009_gene989	1.49e-37	135.0	COG1073@1|root,COG1073@2|Bacteria,2I4CP@201174|Actinobacteria	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_626222_1	1041138.KB890256_gene3489	1.4e-05	51.6	COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,2TTHH@28211|Alphaproteobacteria,4B9Z1@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	GDPD,LacI,Peripla_BP_1,Peripla_BP_3
k59_333431_1	631362.Thi970DRAFT_03186	2.51e-06	48.1	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,1X0B5@135613|Chromatiales	135613|Chromatiales	M	Transposase zinc-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_744419_1	283942.IL1665	2.57e-14	75.5	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,2QFUD@267893|Idiomarinaceae	1236|Gammaproteobacteria	I	Acyl-CoA dehydrogenase	fadE	GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	iSbBS512_1146.SbBS512_E0217	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_744419_2	1123393.KB891316_gene2015	2.47e-109	328.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2VIQW@28216|Betaproteobacteria,1KSGA@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_292784_1	1215092.PA6_016_00390	9.15e-12	69.3	COG2199@1|root,COG3706@2|Bacteria,1MZQ8@1224|Proteobacteria,1RZJU@1236|Gammaproteobacteria,1YHR1@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_860905_1	387631.Asulf_02100	7.39e-28	109.0	COG2236@1|root,arCOG00040@2157|Archaea,2XYCC@28890|Euryarchaeota,247HC@183980|Archaeoglobi	183980|Archaeoglobi	F	Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
k59_333440_1	1357275.AVEL02000101_gene2539	1.94e-65	208.0	COG0204@1|root,COG0204@2|Bacteria,1RDN7@1224|Proteobacteria,1S4Z5@1236|Gammaproteobacteria,1Z5KZ@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
k59_860907_1	765910.MARPU_02975	4.05e-87	267.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RY2H@1236|Gammaproteobacteria,1WX0H@135613|Chromatiales	135613|Chromatiales	GM	epimerase dehydratase	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10
k59_1213727_1	317619.ANKN01000010_gene2943	1.61e-52	182.0	COG3021@1|root,COG3021@2|Bacteria,1G1V5@1117|Cyanobacteria	1117|Cyanobacteria	S	endonuclease exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_1213727_2	1158762.KB898047_gene629	1.38e-07	49.3	COG3071@1|root,COG3071@2|Bacteria,1R0UA@1224|Proteobacteria,1T4PM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
k59_1797405_1	1116375.VEJY3_18786	0.000109	42.7	2AWY3@1|root,31NVR@2|Bacteria,1QKJE@1224|Proteobacteria,1TIPN@1236|Gammaproteobacteria,1XZF9@135623|Vibrionales	135623|Vibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1797405_2	713587.THITH_06345	4.75e-40	141.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1WXEN@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_157532_1	240016.ABIZ01000001_gene2054	1.57e-59	200.0	COG0635@1|root,COG0635@2|Bacteria,46STN@74201|Verrucomicrobia,2ITVN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_509014_1	1235797.C816_00499	1.09e-06	55.5	COG0535@1|root,COG0535@2|Bacteria,1V078@1239|Firmicutes,24C2P@186801|Clostridia	186801|Clostridia	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
k59_1213739_1	243231.GSU1523	3.3e-19	85.5	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,42N0I@68525|delta/epsilon subdivisions,2WMUX@28221|Deltaproteobacteria,43T33@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
k59_685742_1	987059.RBXJA2T_14451	6.43e-06	48.1	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2VHHJ@28216|Betaproteobacteria,1KJN9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
k59_685742_2	1499689.CCNN01000006_gene557	2.71e-19	87.4	COG2761@1|root,COG2761@2|Bacteria,1TZ1N@1239|Firmicutes,24CEW@186801|Clostridia,36HN3@31979|Clostridiaceae	186801|Clostridia	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
k59_1448978_1	933262.AXAM01000010_gene1395	2.96e-109	328.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,42N2A@68525|delta/epsilon subdivisions,2WIP6@28221|Deltaproteobacteria,2MI9Q@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_567526_1	1121405.dsmv_1445	7.23e-103	315.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2MI6Q@213118|Desulfobacterales	28221|Deltaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_1106159_1	446466.Cfla_1606	5.43e-91	295.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4F1PG@85016|Cellulomonadaceae	201174|Actinobacteria	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1564887_1	207559.Dde_3424	8.19e-117	360.0	COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,42M86@68525|delta/epsilon subdivisions,2WIT1@28221|Deltaproteobacteria,2M8F1@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Subunit R is required for both nuclease and ATPase activities, but not for modification	hsdR	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
k59_860935_1	880072.Desac_2700	4.83e-27	111.0	COG1488@1|root,COG1488@2|Bacteria,1R5W0@1224|Proteobacteria,42NQQ@68525|delta/epsilon subdivisions,2WJ4V@28221|Deltaproteobacteria,2MQV1@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C
k59_1033088_1	472759.Nhal_2414	4.25e-47	166.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1WWJ0@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_1389113_1	290399.Arth_0897	7.89e-50	160.0	COG0662@1|root,COG0662@2|Bacteria,2IKT6@201174|Actinobacteria	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_1389113_2	36809.MAB_2589c	9.52e-29	118.0	COG3305@1|root,COG3305@2|Bacteria,2GNU5@201174|Actinobacteria,23638@1762|Mycobacteriaceae	201174|Actinobacteria	S	Predicted membrane protein (DUF2127)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2127
k59_1389113_3	446470.Snas_5792	7.03e-07	57.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
k59_744468_1	999541.bgla_2g27990	4.01e-38	146.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,1K22A@119060|Burkholderiaceae	28216|Betaproteobacteria	EQ	5-oxoprolinase	-	-	3.5.2.14,3.5.2.9	ko:K01469,ko:K01473	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00251,R03187	RC00553,RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_1389126_1	398525.KB900701_gene1765	1.46e-06	48.9	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,3JQVB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_1389126_2	1038862.KB893837_gene1667	3.08e-25	100.0	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2TVBT@28211|Alphaproteobacteria,3JR9H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
k59_1564901_1	765910.MARPU_15110	2.52e-52	179.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1WWHC@135613|Chromatiales	135613|Chromatiales	J	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
k59_1564901_2	1266925.JHVX01000004_gene1271	3.72e-17	77.8	COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,2VSE2@28216|Betaproteobacteria,3738N@32003|Nitrosomonadales	28216|Betaproteobacteria	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
k59_795917_1	572477.Alvin_1245	7.3e-57	184.0	COG1122@1|root,COG1122@2|Bacteria,1RCNM@1224|Proteobacteria,1S27Z@1236|Gammaproteobacteria,1WY29@135613|Chromatiales	135613|Chromatiales	P	ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_292878_1	1122933.JNIY01000003_gene92	3e-15	79.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4F24H@85016|Cellulomonadaceae	201174|Actinobacteria	P	Sulfate permease family	-	GO:0000103,GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006790,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008152,GO:0008272,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0017076,GO:0019001,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0097159,GO:0098656,GO:0098660,GO:0098661,GO:1901265,GO:1901363,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_795923_1	1385518.N798_17090	1.11e-44	163.0	COG0438@1|root,COG1413@1|root,COG0438@2|Bacteria,COG1413@2|Bacteria,2HMNV@201174|Actinobacteria,4FFZP@85021|Intrasporangiaceae	201174|Actinobacteria	CM	Glycosyltransferase Family 4	-	-	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1,HEAT_2
k59_567557_1	414684.RC1_1718	2.3e-67	217.0	COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,2TRTR@28211|Alphaproteobacteria,2JR46@204441|Rhodospirillales	204441|Rhodospirillales	Q	Homospermidine synthase	hss	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_1033116_1	502025.Hoch_2313	5.84e-26	109.0	COG3568@1|root,COG3568@2|Bacteria,1RGY4@1224|Proteobacteria	1224|Proteobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_1797452_2	290400.Jann_3107	4.01e-36	129.0	COG1136@1|root,COG1136@2|Bacteria,1RA1K@1224|Proteobacteria,2U7CA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG1136 ABC-type antimicrobial peptide transport system ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1623113_1	76114.ebA883	1.79e-129	378.0	COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,2VH1W@28216|Betaproteobacteria,2KVXA@206389|Rhodocyclales	206389|Rhodocyclales	S	cytochrome d1 heme	nirF	-	-	ko:K19345	-	-	-	-	ko00000	-	-	-	Cytochrom_D1
k59_686759_1	911045.PSE_3658	2.07e-35	137.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TTPD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glutamine synthetase	glnA	GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0034024,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_158542_1	247633.GP2143_10292	1.23e-63	202.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,1J5AA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
k59_1515896_1	420324.KI912069_gene6434	1.86e-57	194.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2TRPX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_1798335_2	713586.KB900536_gene123	4.16e-175	494.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,1WX6T@135613|Chromatiales	135613|Chromatiales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
k59_1390138_1	1033802.SSPSH_000418	1.24e-17	84.3	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	glnG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1281690_1	1121921.KB898715_gene29	4.31e-47	167.0	COG2706@1|root,COG2706@2|Bacteria,1RB38@1224|Proteobacteria,1SNAF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_158548_1	290340.AAur_3168	4.76e-34	129.0	COG0438@1|root,COG0438@2|Bacteria,2GJI0@201174|Actinobacteria,1WC02@1268|Micrococcaceae	201174|Actinobacteria	H	Glycosyl transferases group 1	wcnD	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_745474_1	543728.Vapar_2223	3.51e-77	245.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHZI@28216|Betaproteobacteria,4AC4M@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_1450202_1	292415.Tbd_2635	5.87e-31	117.0	COG0494@1|root,COG0494@2|Bacteria,1MYSK@1224|Proteobacteria,2W3WC@28216|Betaproteobacteria	28216|Betaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_1450202_2	765914.ThisiDRAFT_2424	3.95e-24	99.4	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RPM1@1236|Gammaproteobacteria,1WW4Q@135613|Chromatiales	135613|Chromatiales	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_158549_1	478801.Ksed_12510	1.62e-83	271.0	COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,1ZVKP@145357|Dermacoccaceae	201174|Actinobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_1565936_1	395493.BegalDRAFT_1310	1.12e-140	406.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RQBM@1236|Gammaproteobacteria,4607F@72273|Thiotrichales	72273|Thiotrichales	E	PFAM Aminotransferase class I and II	-	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_686786_2	522306.CAP2UW1_2084	4.25e-33	127.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1KQCV@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1742998_1	105559.Nwat_0712	1.69e-66	223.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1WWT9@135613|Chromatiales	135613|Chromatiales	O	Belongs to the ClpA ClpB family	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_216768_1	1049564.TevJSym_ao00100	2e-14	72.4	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1J4IQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	COG0303 Molybdopterin biosynthesis enzyme	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_216768_2	1366050.N234_13160	3.99e-25	96.3	COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,2VVSP@28216|Betaproteobacteria,1K984@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
k59_216768_3	1192124.LIG30_0418	3.58e-22	90.1	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,2VRMG@28216|Betaproteobacteria,1K74K@119060|Burkholderiaceae	28216|Betaproteobacteria	H	PFAM molybdopterin biosynthesis MoaE	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
k59_1798361_1	189753.AXAS01000001_gene3768	3e-73	245.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3JR86@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K21134	-	M00821	-	-	ko00000,ko00002,ko02000	2.A.6.2.27	-	-	ACR_tran
k59_686798_1	1121374.KB891585_gene2345	2.69e-06	55.5	COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,1RMUU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	flagellar	flhF	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
k59_1515937_1	105422.BBPM01000020_gene2779	1.99e-30	116.0	COG1569@1|root,COG1569@2|Bacteria,2IMP1@201174|Actinobacteria	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
k59_1034297_1	870187.Thini_0328	1.27e-117	349.0	COG0388@1|root,COG1247@1|root,COG0388@2|Bacteria,COG1247@2|Bacteria,1MX4I@1224|Proteobacteria,1RP30@1236|Gammaproteobacteria,4603U@72273|Thiotrichales	72273|Thiotrichales	M	carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
k59_745507_1	398513.BBNG_01809	0.00027	49.3	COG1414@1|root,COG2865@1|root,COG1414@2|Bacteria,COG2865@2|Bacteria,2I3IG@201174|Actinobacteria,4CZRW@85004|Bifidobacteriales	201174|Actinobacteria	K	Putative ATP-dependent DNA helicase recG C-terminal	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4,MarR_2
k59_1107394_1	1335757.SPICUR_08660	1.49e-56	195.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1WW2F@135613|Chromatiales	135613|Chromatiales	P	Chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
k59_1214980_2	909663.KI867150_gene1086	5.37e-24	102.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42N8J@68525|delta/epsilon subdivisions,2WK63@28221|Deltaproteobacteria,2MRGY@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1107395_1	1307759.JOMJ01000004_gene2844	3.03e-93	297.0	COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,42N23@68525|delta/epsilon subdivisions,2WKW2@28221|Deltaproteobacteria,2M7Z1@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	ABC transporter, transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
k59_1743025_1	583345.Mmol_1894	4.18e-42	153.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2VHJ4@28216|Betaproteobacteria,2KKFE@206350|Nitrosomonadales	206350|Nitrosomonadales	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_1034310_1	543632.JOJL01000068_gene3305	2.24e-77	243.0	COG1236@1|root,COG1236@2|Bacteria,2HEXB@201174|Actinobacteria,4DB1K@85008|Micromonosporales	201174|Actinobacteria	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL
k59_216800_1	697282.Mettu_1255	6.56e-28	108.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,1S68H@1236|Gammaproteobacteria,1XFGM@135618|Methylococcales	135618|Methylococcales	H	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
k59_216800_2	1123399.AQVE01000004_gene2538	9.34e-11	62.0	COG1100@1|root,COG1100@2|Bacteria,1R1W9@1224|Proteobacteria,1SK3H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF697,MMR_HSR1
k59_1565983_1	269797.Mbar_A1979	2.62e-13	76.3	COG0747@1|root,arCOG01534@2157|Archaea,2XVBN@28890|Euryarchaeota,2NAKC@224756|Methanomicrobia	224756|Methanomicrobia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1743052_1	1396858.Q666_04700	1e-68	222.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,4642R@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	pilR	-	-	ko:K02481,ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_451506_1	349521.HCH_04956	6.62e-39	145.0	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,1RPAE@1236|Gammaproteobacteria,1XK1Y@135619|Oceanospirillales	135619|Oceanospirillales	T	Universal stress protein UspA and related nucleotide-binding	ydaA	-	-	ko:K14055	-	-	-	-	ko00000	-	-	-	Usp
k59_862256_1	883080.HMPREF9697_01420	5.9e-49	166.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,2TTDW@28211|Alphaproteobacteria,3JVCB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Thiosulfate-oxidizing multienzyme system protein SoxA	MA20_22830	-	-	ko:K17222	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	-
k59_862256_2	911045.PSE_1365	5.37e-18	79.7	COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,2U94T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	oxidation protein	soxZ	-	-	ko:K17227	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxZ
k59_1151278_1	395493.BegalDRAFT_2990	4.55e-49	170.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,45ZXR@72273|Thiotrichales	72273|Thiotrichales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_1151278_2	1209072.ALBT01000008_gene2932	5.83e-57	187.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1FGK3@10|Cellvibrio	1236|Gammaproteobacteria	K	helix_turn_helix, cAMP Regulatory protein	anr	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	Crp,HTH_Crp_2,cNMP_binding
k59_1107426_1	1047013.AQSP01000126_gene2727	2.5e-29	105.0	COG1278@1|root,COG1278@2|Bacteria,2NPXP@2323|unclassified Bacteria	2|Bacteria	K	'Cold-shock' DNA-binding domain	cspA	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_568699_1	1461579.CCNK01000011_gene290	1.16e-18	82.4	COG2846@1|root,COG2846@2|Bacteria,1MVCQ@1224|Proteobacteria,1RPY6@1236|Gammaproteobacteria,1Y9TT@135625|Pasteurellales	135625|Pasteurellales	D	Di-iron-containing protein involved in the repair of iron-sulfur clusters	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin
k59_758694_2	1141663.OOC_06913	9.74e-36	128.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,3Z83B@586|Providencia	1236|Gammaproteobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18,3.5.4.4	ko:K00969,ko:K01488	ko00230,ko00760,ko01100,ko05340,map00230,map00760,map01100,map05340	M00115	R00137,R01560,R02556,R03005	RC00002,RC00477	ko00000,ko00001,ko00002,ko01000	-	-	iECUMN_1333.ECUMN_0733,iJN746.PP_4810,iPC815.YPO2607,iSbBS512_1146.SbBS512_E0612	CTP_transf_like
k59_806738_2	335543.Sfum_3013	7.52e-40	151.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
k59_758707_1	913325.N799_11280	7.02e-97	300.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1X36F@135614|Xanthomonadales	135614|Xanthomonadales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_1754486_1	765913.ThidrDRAFT_2793	7.22e-38	134.0	COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,1RNSJ@1236|Gammaproteobacteria,1WY08@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4_21
k59_1754486_2	765910.MARPU_03915	1.49e-48	170.0	COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1WWSK@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB
k59_1580213_1	1267005.KB911257_gene864	6.12e-102	306.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2TTGS@28211|Alphaproteobacteria,3N68V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_1809264_1	996637.SGM_3982	1.92e-15	78.6	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria	201174|Actinobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_758724_1	1095767.CAHD01000005_gene2435	3.69e-91	292.0	COG1012@1|root,COG1454@1|root,COG1012@2|Bacteria,COG1454@2|Bacteria,2GJI2@201174|Actinobacteria,4F0XP@85016|Cellulomonadaceae	201174|Actinobacteria	C	belongs to the iron- containing alcohol dehydrogenase family	adhE	-	1.1.1.1,1.2.1.10,1.2.1.81	ko:K04072,ko:K15515	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	-	R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh,Fe-ADH
k59_1228558_1	1190603.AJYD01000029_gene4425	3.8e-14	71.6	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1NR3M@1224|Proteobacteria,1T1WT@1236|Gammaproteobacteria,1XSS8@135623|Vibrionales	135623|Vibrionales	P	NAD(FAD)-dependent dehydrogenases	cdr	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
k59_806774_1	1286631.X805_13800	6.26e-66	216.0	COG2262@1|root,COG2262@2|Bacteria,1QV04@1224|Proteobacteria,2WGNW@28216|Betaproteobacteria,1KPDD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of unknown function (DUF3482)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3482,MMR_HSR1
k59_1809294_1	1397666.RS24_00758	1.89e-114	349.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,4BPW2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC transporter transmembrane region	msbA2	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_229667_1	580332.Slit_1609	4.56e-89	267.0	COG1034@1|root,COG1034@2|Bacteria,1QVC7@1224|Proteobacteria,2VI6U@28216|Betaproteobacteria,44W9N@713636|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	hoxU	-	1.12.1.2	ko:K18006	-	-	-	-	ko00000,ko01000	-	-	-	Fer2_4,Fer4_15,NADH-G_4Fe-4S_3
k59_876905_1	335543.Sfum_3500	2.05e-69	218.0	COG0561@1|root,COG0561@2|Bacteria,1R4WX@1224|Proteobacteria,42P98@68525|delta/epsilon subdivisions,2WJWW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	hydrolases of the HAD superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
k59_1403700_1	945713.IALB_0215	1.18e-63	199.0	COG2818@1|root,COG2818@2|Bacteria	2|Bacteria	L	DNA-3-methyladenine glycosylase activity	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
k59_1228584_1	1187851.A33M_0978	4.65e-66	214.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_229675_1	391600.ABRU01000018_gene3031	2.9e-07	54.3	COG2021@1|root,COG2021@2|Bacteria,1PNUE@1224|Proteobacteria,2V1DE@28211|Alphaproteobacteria,2KGUU@204458|Caulobacterales	204458|Caulobacterales	E	Belongs to the AB hydrolase superfamily. MetX family	-	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_1637717_2	765912.Thimo_3103	0.000247	47.0	COG4701@1|root,COG4701@2|Bacteria,1N6NR@1224|Proteobacteria,1SEGX@1236|Gammaproteobacteria,1WZ6W@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
k59_1050057_1	987059.RBXJA2T_12022	2.05e-83	254.0	COG1075@1|root,COG1075@2|Bacteria,1NJNA@1224|Proteobacteria,2VPNT@28216|Betaproteobacteria,1KNTZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,PGAP1
k59_876921_1	1313172.YM304_10660	4.76e-147	426.0	COG0055@1|root,COG0055@2|Bacteria,2GIY6@201174|Actinobacteria,4CMWB@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1228595_1	1121438.JNJA01000008_gene3867	2.49e-32	129.0	COG1226@1|root,COG2114@1|root,COG1226@2|Bacteria,COG2114@2|Bacteria,1R86S@1224|Proteobacteria,4317C@68525|delta/epsilon subdivisions,2WWWJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1809319_1	706587.Desti_1689	3.83e-113	343.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2MR7D@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_876925_1	1043493.BBLU01000002_gene1781	2.37e-32	134.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2GJGR@201174|Actinobacteria	201174|Actinobacteria	L	ComEC Rec2-related protein	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_638759_1	1499967.BAYZ01000088_gene5091	7.54e-22	97.1	COG1044@1|root,COG1044@2|Bacteria,2NNSF@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	ic_1306.c0216	Hexapep,Hexapep_2,LpxD
k59_758780_1	1197906.CAJQ02000003_gene3255	3.17e-71	225.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,3JVHX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_806807_1	1121033.AUCF01000036_gene3983	2.64e-41	153.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2TR0Q@28211|Alphaproteobacteria,2JQZC@204441|Rhodospirillales	204441|Rhodospirillales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1580312_1	1026882.MAMP_01180	5.58e-23	94.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,460JE@72273|Thiotrichales	72273|Thiotrichales	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_1580312_2	497321.C664_16108	1.79e-46	159.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2VHU0@28216|Betaproteobacteria,2KV1W@206389|Rhodocyclales	206389|Rhodocyclales	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_806808_1	1123368.AUIS01000007_gene2729	9.19e-46	156.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,2NCK7@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_806808_2	396588.Tgr7_2464	3.02e-19	86.7	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1WWNU@135613|Chromatiales	135613|Chromatiales	E	PFAM Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_758784_1	1120917.AQXM01000039_gene1184	1.21e-45	150.0	COG0256@1|root,COG0256@2|Bacteria,2IKTX@201174|Actinobacteria,1W9G5@1268|Micrococcaceae	201174|Actinobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0008150,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
k59_1580323_1	1120936.KB907209_gene1259	1.55e-30	116.0	COG1802@1|root,COG1802@2|Bacteria,2IBT4@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_1580323_2	1906.SFRA_14900	0.000252	43.1	COG1116@1|root,COG1116@2|Bacteria,2GM73@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system, ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
k59_1162496_1	1121405.dsmv_2622	1.27e-135	395.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42PZ6@68525|delta/epsilon subdivisions,2WKNQ@28221|Deltaproteobacteria,2MI1H@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Amino acid kinase family	-	-	1.1.1.3,2.7.2.4	ko:K00928,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3
k59_229719_1	1122201.AUAZ01000002_gene1087	5.4e-48	173.0	COG2334@1|root,COG2334@2|Bacteria,1QV5C@1224|Proteobacteria,1T293@1236|Gammaproteobacteria,46A4U@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Ecdysteroid kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_876960_1	935567.JAES01000036_gene2913	4.64e-46	158.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,1RP2I@1236|Gammaproteobacteria,1X49A@135614|Xanthomonadales	135614|Xanthomonadales	P	COG0798 Arsenite efflux pump ACR3 and related permeases	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
k59_1580333_1	999541.bgla_1g13380	1.43e-93	301.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,1K2N9@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_1050129_1	1121448.DGI_0817	1.76e-20	95.5	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2MH92@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,CHASE,DUF3365,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_1050130_1	1121405.dsmv_1660	1.69e-41	144.0	COG2010@1|root,COG2993@1|root,COG2010@2|Bacteria,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,42NZG@68525|delta/epsilon subdivisions,2WNX9@28221|Deltaproteobacteria,2MKZC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	cytochrome C oxidase mono-heme subunit FixO	-	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixO
k59_1050130_2	1121405.dsmv_1659	2.41e-22	89.4	COG3197@1|root,COG3197@2|Bacteria,1P4MU@1224|Proteobacteria,432XF@68525|delta/epsilon subdivisions,2WYHY@28221|Deltaproteobacteria,2MPDK@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Cytochrome oxidase maturation protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1580362_1	1157635.KB892006_gene3285	2.77e-26	103.0	COG0169@1|root,COG0169@2|Bacteria,2GPQQ@201174|Actinobacteria	201174|Actinobacteria	E	Shikimate dehydrogenase	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2552c	Shikimate_DH,Shikimate_dh_N
k59_1580362_2	1386089.N865_01025	1.87e-24	102.0	COG1559@1|root,COG1559@2|Bacteria,2GKGQ@201174|Actinobacteria,4FFI0@85021|Intrasporangiaceae	201174|Actinobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_1050150_1	446469.Sked_10900	3.3e-65	204.0	COG2606@1|root,COG2606@2|Bacteria,2IHS8@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily	ybaK	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
k59_638803_1	2340.JV46_16550	1.51e-138	402.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1J53B@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Aminotransferase	hemL	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iUMNK88_1353.UMNK88_158	Aminotran_3
k59_1050156_1	754252.PFREUD_18520	1.96e-55	193.0	COG1226@1|root,COG1226@2|Bacteria	2|Bacteria	P	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)	kch	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_N
k59_876990_1	765911.Thivi_3617	2.14e-35	126.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,1WWQJ@135613|Chromatiales	135613|Chromatiales	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
k59_876990_2	439235.Dalk_2211	3.56e-06	50.4	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,42NMY@68525|delta/epsilon subdivisions,2WJ8S@28221|Deltaproteobacteria,2MHS5@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the MurCDEF family	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1403817_1	305700.B447_10218	8.84e-07	49.3	COG2212@1|root,COG2212@2|Bacteria,1N90U@1224|Proteobacteria,2VY9Q@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Multiple resistance and pH regulation protein F (MrpF / PhaF)	-	-	-	-	-	-	-	-	-	-	-	-	MrpF_PhaF
k59_1403817_2	1249627.D779_3486	8.49e-37	130.0	COG1863@1|root,COG1863@2|Bacteria,1N7MB@1224|Proteobacteria,1SCQX@1236|Gammaproteobacteria,1WYUR@135613|Chromatiales	135613|Chromatiales	P	PFAM cation antiporter	-	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
k59_229762_1	1121396.KB893063_gene1209	2.41e-46	162.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42Q4P@68525|delta/epsilon subdivisions,2WJHQ@28221|Deltaproteobacteria,2MJRC@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1463030_1	883.DvMF_0209	6.75e-11	62.4	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,42M8N@68525|delta/epsilon subdivisions,2WK7T@28221|Deltaproteobacteria,2M8BS@213115|Desulfovibrionales	28221|Deltaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase	hprA	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_579955_1	1380394.JADL01000001_gene2570	4.17e-35	133.0	COG4783@1|root,COG4783@2|Bacteria,1NP1J@1224|Proteobacteria,2UK80@28211|Alphaproteobacteria,2JXWA@204441|Rhodospirillales	204441|Rhodospirillales	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_638828_1	1049564.TevJSym_ac00130	1.1e-122	371.0	COG4263@1|root,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,1RQSW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide	nosZ	GO:0000041,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0030001,GO:0042597,GO:0044464,GO:0051179,GO:0051234	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	COX2,Cupredoxin_1
k59_347103_1	1267005.KB911263_gene1337	8.89e-49	161.0	COG1585@1|root,COG1585@2|Bacteria,1N241@1224|Proteobacteria,2UC8X@28211|Alphaproteobacteria,3N7B3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	OU	NfeD-like C-terminal, partner-binding	MA20_06475	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
k59_638841_1	446466.Cfla_0029	1.32e-59	199.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4F0XS@85016|Cellulomonadaceae	201174|Actinobacteria	T	SMART protein phosphatase 2C domain protein	pstP	GO:0000287,GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010563,GO:0010605,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0030145,GO:0030312,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0033673,GO:0036211,GO:0042325,GO:0042326,GO:0042578,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043392,GO:0043412,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0045859,GO:0045936,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051098,GO:0051100,GO:0051101,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
k59_877047_1	335543.Sfum_0650	8.39e-53	178.0	COG0589@1|root,COG0589@2|Bacteria,1REA3@1224|Proteobacteria,42RXY@68525|delta/epsilon subdivisions,2WNM6@28221|Deltaproteobacteria,2MSDJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	PFAM UspA domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1809427_1	446466.Cfla_2261	1.89e-49	160.0	2DVEK@1|root,33VIT@2|Bacteria,2IG5Q@201174|Actinobacteria	201174|Actinobacteria	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
k59_1809427_2	446466.Cfla_2262	9.06e-71	216.0	arCOG11412@1|root,31S84@2|Bacteria,2IHRW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1809427_3	67373.JOBF01000010_gene1833	3.45e-11	57.8	arCOG11411@1|root,33A8Q@2|Bacteria,2GRHE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1164305_3	768671.ThimaDRAFT_1850	1.58e-51	166.0	28NV7@1|root,2ZBTD@2|Bacteria,1RAH4@1224|Proteobacteria,1S2YP@1236|Gammaproteobacteria,1WY67@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_464229_2	396588.Tgr7_1533	9.87e-104	306.0	COG3264@1|root,COG3264@2|Bacteria,1QUBW@1224|Proteobacteria,1T1SF@1236|Gammaproteobacteria,1WY8X@135613|Chromatiales	135613|Chromatiales	M	mechanosensitive ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel,TM_helix
k59_231163_1	1397528.Q671_06920	1.47e-20	96.3	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1XH4C@135619|Oceanospirillales	135619|Oceanospirillales	D	COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1164322_1	1247963.JPHU01000001_gene2061	7.68e-51	176.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_173327_1	1123065.ATWL01000007_gene3282	2.61e-103	307.0	COG1159@1|root,COG1159@2|Bacteria,2GJJE@201174|Actinobacteria	201174|Actinobacteria	M	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
k59_173327_2	1304865.JAGF01000001_gene2881	6.15e-33	126.0	COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4F0HR@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM CBS domain containing protein	corC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_700282_2	572477.Alvin_2004	7.22e-15	71.6	COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1WWJB@135613|Chromatiales	135613|Chromatiales	E	PFAM Amino acid-binding ACT	-	-	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT_6
k59_1581631_1	1123053.AUDG01000060_gene383	3.34e-13	67.0	COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,1S3RF@1236|Gammaproteobacteria,1WXW9@135613|Chromatiales	135613|Chromatiales	C	Cytochrome	-	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
k59_1581631_2	765912.Thimo_1583	3.98e-50	164.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,1S24R@1236|Gammaproteobacteria,1WXG3@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
k59_1230187_1	857087.Metme_3201	8.08e-20	94.4	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1XDWV@135618|Methylococcales	135618|Methylococcales	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5
k59_348487_1	1049564.TevJSym_bg00190	1.46e-16	74.3	COG1057@1|root,COG1057@2|Bacteria	2|Bacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18,3.5.4.4,3.6.1.55	ko:K00969,ko:K01488,ko:K03574	ko00230,ko00760,ko01100,ko05340,map00230,map00760,map01100,map05340	M00115	R00137,R01560,R02556,R03005	RC00002,RC00477	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	iECUMN_1333.ECUMN_0733,iJN746.PP_4810,iPC815.YPO2607,iSbBS512_1146.SbBS512_E0612	CTP_transf_like
k59_348487_2	472759.Nhal_0540	1.94e-58	192.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1WWUV@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_464262_1	91464.S7335_5344	3.92e-17	82.0	COG0469@1|root,COG0469@2|Bacteria,1G1IY@1117|Cyanobacteria,1GZ8S@1129|Synechococcus	1117|Cyanobacteria	G	Belongs to the pyruvate kinase family	pykF	GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
k59_1230194_1	1121456.ATVA01000011_gene1701	1.31e-42	157.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,42PJQ@68525|delta/epsilon subdivisions,2WKR4@28221|Deltaproteobacteria,2M7SH@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	iAF987.Gmet_3470	CBS,Voltage_CLC
k59_700296_1	380358.XALC_0347	6.45e-35	133.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1X36F@135614|Xanthomonadales	135614|Xanthomonadales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_1164364_1	670307.HYPDE_31458	1.85e-74	234.0	COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,2TRD4@28211|Alphaproteobacteria,3N86C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	tRNA synthetases class II (D, K and N)	genX	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
k59_1164369_1	583355.Caka_2879	5.3e-106	320.0	COG1215@1|root,COG1215@2|Bacteria,46SF7@74201|Verrucomicrobia,3K9BK@414999|Opitutae	414999|Opitutae	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_2_3
k59_1063399_1	487796.Flav2ADRAFT_1417	2.85e-28	115.0	COG0168@1|root,COG0168@2|Bacteria,4NGMF@976|Bacteroidetes,1HXPV@117743|Flavobacteriia	976|Bacteroidetes	P	Trk-type K transport systems, membrane components	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_1063399_2	1379270.AUXF01000002_gene1182	9.97e-48	158.0	COG0035@1|root,COG0035@2|Bacteria,1ZT1C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
k59_243004_1	1223521.BBJX01000005_gene1988	1.17e-36	139.0	COG1541@1|root,COG1541@2|Bacteria,1P22K@1224|Proteobacteria,2WGC2@28216|Betaproteobacteria,4ACC7@80864|Comamonadaceae	28216|Betaproteobacteria	H	coenzyme F390 synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
k59_1003853_3	1218352.B597_003830	6.59e-112	325.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,1RPU6@1236|Gammaproteobacteria,1Z22V@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	C	COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
k59_124277_1	1026882.MAMP_01504	1.63e-115	347.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,460FW@72273|Thiotrichales	72273|Thiotrichales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_768922_1	396588.Tgr7_0574	1.87e-77	243.0	COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,1WXN5@135613|Chromatiales	135613|Chromatiales	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,DUF3335
k59_1829878_1	754476.Q7A_2485	7.6e-48	169.0	COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,460CG@72273|Thiotrichales	72273|Thiotrichales	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,LysM
k59_949538_1	290397.Adeh_3163	3.78e-46	170.0	2F2IM@1|root,33VFK@2|Bacteria,1RIX8@1224|Proteobacteria,42T5Z@68525|delta/epsilon subdivisions,2WPA9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
k59_68861_1	1249627.D779_2707	7.63e-12	65.9	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,1RPBT@1236|Gammaproteobacteria,1WWHF@135613|Chromatiales	135613|Chromatiales	EGP	Major facilitator superfamily	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
k59_68861_2	342610.Patl_1541	2.33e-69	220.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,2Q15F@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iE2348C_1286.E2348C_2469,iEC55989_1330.EC55989_2573,iECO103_1326.ECO103_2794,iECO111_1330.ECO111_3077,iECO26_1355.ECO26_3317,iECSE_1348.ECSE_2638,iECW_1372.ECW_m2518,iEKO11_1354.EKO11_1436,iSSON_1240.SSON_2387,iUMNK88_1353.UMNK88_2882,iWFL_1372.ECW_m2518	Chorismate_synt
k59_183009_1	1385521.N803_06885	4.3e-28	113.0	COG1104@1|root,COG1104@2|Bacteria,2GJ2B@201174|Actinobacteria,4FF85@85021|Intrasporangiaceae	201174|Actinobacteria	E	Aminotransferase	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5,TusA
k59_768928_1	768671.ThimaDRAFT_1585	2.83e-42	148.0	COG2378@1|root,COG2378@2|Bacteria,1P2ZE@1224|Proteobacteria,1RYHJ@1236|Gammaproteobacteria,1WXZG@135613|Chromatiales	135613|Chromatiales	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
k59_768928_2	631362.Thi970DRAFT_04541	1.22e-33	119.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,1WYQV@135613|Chromatiales	135613|Chromatiales	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
k59_1829884_1	1123073.KB899241_gene2606	6.9e-165	479.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1X34U@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1532841_2	553385.JEMF01000037_gene2712	8.53e-35	126.0	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,1XK2G@135619|Oceanospirillales	135619|Oceanospirillales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
k59_1301739_1	583355.Caka_1210	1.54e-36	140.0	COG2202@1|root,COG2208@1|root,COG2202@2|Bacteria,COG2208@2|Bacteria,46U96@74201|Verrucomicrobia	74201|Verrucomicrobia	KT	PFAM Stage II sporulation E family protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	PAS_3,PAS_4,SpoIIE
k59_10520_2	105559.Nwat_2740	1.43e-61	196.0	COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,1RQ7W@1236|Gammaproteobacteria,1X286@135613|Chromatiales	135613|Chromatiales	C	Oxidoreductase FAD-binding domain	-	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind
k59_652668_1	1313172.YM304_00750	1.51e-37	142.0	COG1403@1|root,COG1403@2|Bacteria,2GVP9@201174|Actinobacteria	201174|Actinobacteria	V	Domain of unknown function (DUF222)	-	-	-	-	-	-	-	-	-	-	-	-	DUF222
k59_768935_1	1267535.KB906767_gene2026	0.000439	47.0	COG1225@1|root,COG1225@2|Bacteria,3Y9DJ@57723|Acidobacteria	57723|Acidobacteria	O	Glutathione peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_1829898_1	909663.KI867150_gene618	1.47e-20	87.4	COG0346@1|root,COG0346@2|Bacteria,1Q268@1224|Proteobacteria,437T7@68525|delta/epsilon subdivisions,2X32F@28221|Deltaproteobacteria,2MRN9@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
k59_1829898_2	335543.Sfum_1393	7.51e-41	142.0	COG0483@1|root,COG0483@2|Bacteria,1NVDS@1224|Proteobacteria,42ZN3@68525|delta/epsilon subdivisions,2WUWR@28221|Deltaproteobacteria,2MRNA@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_244319_1	1255043.TVNIR_0848	1.33e-93	290.0	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,1RMCU@1236|Gammaproteobacteria,1X259@135613|Chromatiales	135613|Chromatiales	H	CobB/CobQ-like glutamine amidotransferase domain	-	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,GATase_3
k59_1532853_2	713586.KB900536_gene1159	2.08e-50	161.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,1S973@1236|Gammaproteobacteria,1WYKG@135613|Chromatiales	135613|Chromatiales	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
k59_711326_1	85643.Tmz1t_1214	1.52e-31	119.0	COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,2VSHR@28216|Betaproteobacteria,2KXAQ@206389|Rhodocyclales	206389|Rhodocyclales	S	Uncharacterized protein conserved in bacteria (DUF2062)	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
k59_1767442_1	981369.JQMJ01000004_gene5028	7.89e-32	125.0	COG0671@1|root,COG0671@2|Bacteria,2GMYU@201174|Actinobacteria,2NHR4@228398|Streptacidiphilus	201174|Actinobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
k59_68887_1	1089553.Tph_c01430	9.08e-78	256.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia,42HRB@68295|Thermoanaerobacterales	186801|Clostridia	C	Molydopterin dinucleotide binding domain	-	-	1.7.2.3,1.8.5.3	ko:K07306,ko:K07812	ko00920,map00920	-	R09501	RC02555	ko00000,ko00001,ko01000,ko02000	5.A.3.3,5.A.3.4	-	-	Molybdopterin,Molydop_binding
k59_362356_1	1713.JOFV01000018_gene219	1.05e-117	352.0	COG3424@1|root,COG3424@2|Bacteria,2GV0U@201174|Actinobacteria,4F0T0@85016|Cellulomonadaceae	201174|Actinobacteria	Q	FAE1/Type III polyketide synthase-like protein	-	-	-	ko:K16167	-	-	-	-	ko00000,ko01008	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
k59_890614_1	1123053.AUDG01000042_gene917	3.57e-30	128.0	COG0834@1|root,COG2199@1|root,COG0834@2|Bacteria,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,1T5NJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,SBP_bac_3
k59_244336_1	396588.Tgr7_3254	1.32e-83	254.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1WXP3@135613|Chromatiales	135613|Chromatiales	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_244337_1	551275.KB899546_gene2299	1.27e-40	146.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_362361_3	1123393.KB891316_gene1442	4.31e-22	90.1	COG2920@1|root,COG2920@2|Bacteria,1N6BZ@1224|Proteobacteria,2WCAJ@28216|Betaproteobacteria,1KTBU@119069|Hydrogenophilales	119069|Hydrogenophilales	P	DsrC like protein	-	-	-	-	-	-	-	-	-	-	-	-	DsrC
k59_124311_1	1163617.SCD_n02368	4.58e-132	392.0	COG0028@1|root,COG0028@2|Bacteria,1MWVW@1224|Proteobacteria,2VQU4@28216|Betaproteobacteria	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_476440_1	1300345.LF41_2649	3.93e-34	135.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9I0@135614|Xanthomonadales	135614|Xanthomonadales	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1064552_1	118163.Ple7327_1459	8.29e-38	136.0	COG1611@1|root,COG1611@2|Bacteria,1G0YF@1117|Cyanobacteria	1117|Cyanobacteria	S	lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_1829924_1	1026882.MAMP_02476	1.59e-10	60.8	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,460T9@72273|Thiotrichales	72273|Thiotrichales	M	PFAM Surface antigen	-	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,POTRA_TamA_1
k59_828508_1	870187.Thini_3876	3.63e-33	117.0	COG0633@1|root,COG0633@2|Bacteria	2|Bacteria	C	Ferredoxin	ascD	GO:0005575,GO:0005622,GO:0005623,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0046858	1.17.1.1	ko:K00523,ko:K04755,ko:K08952,ko:K08953,ko:K08954,ko:K18077	ko00520,ko00624,ko01100,ko01120,ko01220,map00520,map00624,map01100,map01120,map01220	M00624	R03391,R03392,R05148	RC00230,RC00270	br01602,ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
k59_1650865_1	498211.CJA_1396	5.07e-36	140.0	COG4254@1|root,COG4932@1|root,COG4254@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,1T4AQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta
k59_1475584_1	471853.Bcav_3026	3.08e-84	272.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria	201174|Actinobacteria	L	DNA helicase	pcrA	GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1829935_1	216142.LT40_02630	1.21e-28	114.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Cytochrome c-type biogenesis protein	ccmF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_1829935_2	935863.AWZR01000010_gene748	1.65e-27	104.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,1S5VA@1236|Gammaproteobacteria,1X6HG@135614|Xanthomonadales	135614|Xanthomonadales	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
k59_244351_1	298655.KI912266_gene4404	4.74e-12	64.3	COG2261@1|root,COG2261@2|Bacteria,2GS37@201174|Actinobacteria,4ETMQ@85013|Frankiales	201174|Actinobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
k59_10574_2	1116369.KB890024_gene4706	9.59e-34	122.0	COG5456@1|root,COG5456@2|Bacteria,1N5J5@1224|Proteobacteria,2UC8D@28211|Alphaproteobacteria,43KAD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	integral membrane protein linked to a cation pump	fixH	-	-	-	-	-	-	-	-	-	-	-	FixH
k59_1240588_1	1232410.KI421421_gene3308	5.07e-85	265.0	COG5607@1|root,COG5607@2|Bacteria,1R5I1@1224|Proteobacteria,43B3I@68525|delta/epsilon subdivisions,2X6HB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
k59_68917_1	933262.AXAM01000015_gene101	1.24e-93	290.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42MZJ@68525|delta/epsilon subdivisions,2WJK1@28221|Deltaproteobacteria,2MIBC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_1532881_1	439235.Dalk_3669	1.13e-92	282.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42MSJ@68525|delta/epsilon subdivisions,2WKHJ@28221|Deltaproteobacteria,2MITB@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_10588_1	395493.BegalDRAFT_2004	4.4e-72	229.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,45ZQ6@72273|Thiotrichales	72273|Thiotrichales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_768960_1	1095772.CAHH01000041_gene1283	3.81e-76	237.0	COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_1829948_1	1123070.KB899255_gene1412	4.72e-91	276.0	COG0379@1|root,COG0379@2|Bacteria,46SA1@74201|Verrucomicrobia,2ITV3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Quinolinate synthetase A protein	-	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
k59_1003904_1	251221.35213029	4.31e-19	84.7	COG2020@1|root,COG2020@2|Bacteria,1GB2G@1117|Cyanobacteria	1117|Cyanobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_244380_1	1172188.KB911823_gene525	1.65e-105	313.0	COG2887@1|root,COG2887@2|Bacteria,2GJC5@201174|Actinobacteria,4FFDN@85021|Intrasporangiaceae	201174|Actinobacteria	L	Domain of unknown function DUF83	recB	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	PDDEXK_1
k59_10615_1	1386969.AWTB01000013_gene3312	1.01e-83	267.0	COG1109@1|root,COG1109@2|Bacteria,2GJ3Q@201174|Actinobacteria,4GCGA@85026|Gordoniaceae	201174|Actinobacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	pmmB	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1532891_1	663321.REG_0736	2.46e-44	159.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RR5Z@1236|Gammaproteobacteria,283IW@191675|unclassified Enterobacteriaceae	1236|Gammaproteobacteria	J	Amidase	atzF	-	3.5.1.54,3.5.1.84	ko:K01457,ko:K19837,ko:K21801	ko00220,ko00380,ko00791,ko01100,ko01120,map00220,map00380,map00791,map01100,map01120	-	R00005,R05563	RC01287,RC02756	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_1532891_2	926561.KB900617_gene1426	2.15e-77	242.0	28I7A@1|root,2Z8A6@2|Bacteria,1V22F@1239|Firmicutes,24YPW@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_949628_2	713586.KB900536_gene582	2.97e-87	271.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,1RMB8@1236|Gammaproteobacteria,1WYRX@135613|Chromatiales	135613|Chromatiales	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
k59_890680_1	1122599.AUGR01000006_gene3782	1.05e-100	309.0	28I6N@1|root,2Z89J@2|Bacteria,1MUVT@1224|Proteobacteria,1RQUY@1236|Gammaproteobacteria,1XHY9@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1767488_1	1279019.ARQK01000056_gene298	1.16e-62	214.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales	135613|Chromatiales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_1064633_1	1284679.HMPREF1626_04045	8.36e-24	95.5	COG0717@1|root,COG0717@2|Bacteria,2GKQQ@201174|Actinobacteria,4D3KA@85005|Actinomycetales	201174|Actinobacteria	F	Belongs to the dCTP deaminase family	dcd	GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
k59_1064633_2	471853.Bcav_3822	1.45e-38	141.0	2CFFB@1|root,32S1S@2|Bacteria,2IA1Q@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_711381_1	768671.ThimaDRAFT_3051	1.78e-43	157.0	COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,1RYAY@1236|Gammaproteobacteria,1WW8Z@135613|Chromatiales	135613|Chromatiales	S	pfam abc1	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
k59_1591362_1	1713.JOFV01000010_gene1218	6.16e-142	404.0	COG0090@1|root,COG0090@2|Bacteria,2GK7R@201174|Actinobacteria,4F110@85016|Cellulomonadaceae	201174|Actinobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_300473_2	471853.Bcav_2254	1.03e-71	236.0	COG0339@1|root,COG0339@2|Bacteria,2GM2Z@201174|Actinobacteria	201174|Actinobacteria	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	dcp	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_711384_1	1144275.COCOR_03060	2.13e-52	169.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria,2YXRK@29|Myxococcales	28221|Deltaproteobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_711384_2	1292373.H640_00185	2.88e-27	102.0	COG0256@1|root,COG0256@2|Bacteria,2IKTX@201174|Actinobacteria,4DR5B@85009|Propionibacteriales	201174|Actinobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0008150,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
k59_890691_1	1121438.JNJA01000008_gene4006	2.06e-28	105.0	COG1773@1|root,COG1773@2|Bacteria,1NES3@1224|Proteobacteria,42VN9@68525|delta/epsilon subdivisions,2WRT2@28221|Deltaproteobacteria,2MCJQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the rubredoxin family	-	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0008199,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0055114	-	-	-	-	-	-	-	-	-	-	Rubredoxin
k59_1240641_1	572477.Alvin_2122	0.00041	42.7	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,1RQQT@1236|Gammaproteobacteria,1WW5C@135613|Chromatiales	135613|Chromatiales	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
k59_1240641_2	203122.Sde_0727	4.76e-40	147.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,4641Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	GO:0003674,GO:0003824,GO:0004652,GO:0004810,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0070566,GO:0071704,GO:0090304,GO:1901360,GO:1990817	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
k59_1829985_1	394221.Mmar10_0331	9.64e-24	105.0	COG4783@1|root,COG5616@1|root,COG4783@2|Bacteria,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,2TWZ1@28211|Alphaproteobacteria,44159@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Trans_reg_C
k59_652741_1	1279019.ARQK01000060_gene2294	6.04e-11	61.6	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1WW0K@135613|Chromatiales	135613|Chromatiales	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_652741_2	314287.GB2207_03192	4.74e-107	318.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,1J4MD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	COG1131 ABC-type multidrug transport system, ATPase component	yadG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_10659_1	1121935.AQXX01000143_gene4223	9.9e-58	192.0	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,1RMBF@1236|Gammaproteobacteria,1XHQ9@135619|Oceanospirillales	135619|Oceanospirillales	M	heptosyltransferase	waaF	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_1829990_1	1123401.JHYQ01000022_gene1149	6.11e-70	219.0	COG0627@1|root,COG4947@1|root,COG0627@2|Bacteria,COG4947@2|Bacteria,1R6D9@1224|Proteobacteria,1T0S7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_300480_1	1120960.ATXG01000020_gene3318	2.14e-46	169.0	COG0433@1|root,COG0433@2|Bacteria,2IGPW@201174|Actinobacteria,4FR42@85023|Microbacteriaceae	201174|Actinobacteria	S	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_10
k59_1650923_1	768066.HELO_1354	5.81e-15	73.6	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1XH2S@135619|Oceanospirillales	135619|Oceanospirillales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_1650923_3	247639.MGP2080_11513	1.34e-29	110.0	COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,1S94K@1236|Gammaproteobacteria,1J6Y3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2927 DNA polymerase III, chi subunit	holC	GO:0005575,GO:0005622,GO:0005623,GO:0006275,GO:0008150,GO:0009314,GO:0009360,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010556,GO:0010557,GO:0010604,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032298,GO:0032991,GO:0042575,GO:0043846,GO:0043847,GO:0044424,GO:0044464,GO:0045740,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051173,GO:0060255,GO:0061695,GO:0065007,GO:0080090,GO:0090329,GO:1902494,GO:1990234,GO:2000105,GO:2000112	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
k59_1066022_1	471853.Bcav_2193	1.72e-112	335.0	COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria	201174|Actinobacteria	J	Ribosomal protein S1	rpsA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_891630_1	765911.Thivi_1064	2.84e-57	205.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon
k59_1302822_1	1121013.P873_02730	8.17e-17	78.2	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,1S668@1236|Gammaproteobacteria,1XCMT@135614|Xanthomonadales	135614|Xanthomonadales	GT	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
k59_1302822_2	933262.AXAM01000014_gene260	3.5e-20	84.3	COG0347@1|root,COG0347@2|Bacteria,1NPUT@1224|Proteobacteria,42WWB@68525|delta/epsilon subdivisions,2WTEG@28221|Deltaproteobacteria,2MNZ2@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the P(II) protein family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_829364_1	1121385.AQXW01000004_gene3221	1.68e-45	158.0	COG5473@1|root,COG5473@2|Bacteria,2GN5K@201174|Actinobacteria	201174|Actinobacteria	J	Zn-ribbon protein possibly nucleic acid-binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1010593_1	1249627.D779_2617	1.7e-102	314.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1WVY6@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
k59_837503_2	1286106.MPL1_12508	1.58e-73	231.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1RWC8@1236|Gammaproteobacteria,460AJ@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	LeuA_dimer,PALP
k59_720435_1	349521.HCH_03019	9.63e-63	209.0	COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria,1XIE5@135619|Oceanospirillales	135619|Oceanospirillales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	CusF_Ec,HlyD_D23
k59_374670_1	1128111.HMPREF0870_01768	1.05e-35	146.0	COG3087@1|root,COG3087@2|Bacteria,1TP8N@1239|Firmicutes,4H403@909932|Negativicutes	909932|Negativicutes	D	Caudovirus prohead protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S78
k59_374670_2	1095743.HMPREF1054_1770	1.18e-103	327.0	COG5511@1|root,COG5511@2|Bacteria,1MVN4@1224|Proteobacteria,1RRK4@1236|Gammaproteobacteria,1Y7IC@135625|Pasteurellales	135625|Pasteurellales	S	Bacteriophage capsid protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_portal_2
k59_602235_1	314265.R2601_26196	7.1e-16	76.6	COG1764@1|root,COG1764@2|Bacteria,1RH9U@1224|Proteobacteria,2U768@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	redox protein regulator of disulfide bond formation	osmC	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006970,GO:0006972,GO:0006979,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
k59_543854_1	410358.Mlab_0604	1.02e-14	76.6	COG0119@1|root,arCOG02092@2157|Archaea,2XSZJ@28890|Euryarchaeota,2N9FH@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate	cimA	-	2.3.1.182	ko:K09011	ko00290,ko00660,ko01100,ko01210,ko01230,map00290,map00660,map01100,map01210,map01230	M00535	R07399	RC00004,RC01205	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1314083_1	1089551.KE386572_gene4173	0.000862	42.0	COG1028@1|root,COG1028@2|Bacteria,1RAEZ@1224|Proteobacteria,2U7DM@28211|Alphaproteobacteria,4BQDF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	csgA	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_1717548_1	1500301.JQMF01000005_gene3893	6.33e-24	107.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_2
k59_133513_2	367299.JOEE01000001_gene1690	1.5e-104	313.0	COG0624@1|root,COG0624@2|Bacteria,2GJDE@201174|Actinobacteria,4FEEY@85021|Intrasporangiaceae	201174|Actinobacteria	E	Allantoate amidohydrolase	amaB	-	3.5.1.6,3.5.1.87,3.5.3.9	ko:K02083,ko:K06016	ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120	M00046	R00905,R02423,R04666	RC00064,RC00096	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_81123_2	288000.BBta_1458	5.99e-48	162.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2TRX0@28211|Alphaproteobacteria,3JW35@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_1252616_1	582899.Hden_2733	6.22e-11	63.5	COG3474@1|root,COG3474@2|Bacteria,1RIDN@1224|Proteobacteria,2U142@28211|Alphaproteobacteria,3N719@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cytochrome c	cycM	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
k59_1252616_2	670307.HYPDE_37408	3.71e-52	172.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2TUQM@28211|Alphaproteobacteria,3N8R9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
k59_837526_2	591159.ACEZ01000137_gene2193	3e-26	104.0	COG0637@1|root,COG0637@2|Bacteria,2I7TC@201174|Actinobacteria	201174|Actinobacteria	H	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_720456_1	713586.KB900536_gene2631	2.2e-63	196.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1WYSF@135613|Chromatiales	135613|Chromatiales	P	PFAM ApaG domain protein	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
k59_720456_2	1177181.T9A_03245	1.45e-06	47.0	2E3CN@1|root,32YBX@2|Bacteria,1N716@1224|Proteobacteria,1SEFN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_776149_1	746697.Aeqsu_0852	2.69e-60	215.0	COG1572@1|root,COG1572@2|Bacteria,4PMQR@976|Bacteroidetes,1IK7W@117743|Flavobacteriia	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C
k59_24913_1	580332.Slit_2941	1.04e-84	264.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria,44W7S@713636|Nitrosomonadales	28216|Betaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_1660096_1	519989.ECTPHS_03036	3.74e-95	301.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1WW5E@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_543866_2	888056.HMPREF9062_0789	7.55e-59	186.0	COG0229@1|root,COG0229@2|Bacteria,2IHV0@201174|Actinobacteria,4D5ID@85005|Actinomycetales	201174|Actinobacteria	C	Peptide-methionine (R)-S-oxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
k59_1599951_1	497964.CfE428DRAFT_2160	9.63e-103	306.0	COG0005@1|root,COG0005@2|Bacteria,46UP8@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Phosphorylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PNP_UDP_1
k59_1011076_1	1121456.ATVA01000002_gene3178	1.82e-30	111.0	COG2204@1|root,COG2204@2|Bacteria,1RHQV@1224|Proteobacteria,42T2A@68525|delta/epsilon subdivisions,2WPA0@28221|Deltaproteobacteria,2MBWC@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_133525_1	1123065.ATWL01000034_gene3426	4.73e-98	296.0	COG4992@1|root,COG4992@2|Bacteria,2GK0J@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	rocD	-	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_258678_1	384765.SIAM614_03396	1.28e-86	260.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2TR43@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	chvI	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K14981	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_309031_1	471853.Bcav_0857	2.66e-37	145.0	COG5002@1|root,COG5002@2|Bacteria,2I2TP@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9
k59_661870_1	243233.MCA0318	1.25e-94	295.0	COG1858@1|root,COG1999@1|root,COG1858@2|Bacteria,COG1999@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1XERF@135618|Methylococcales	135618|Methylococcales	C	PFAM Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
k59_258681_1	1108045.GORHZ_217_00220	7.87e-36	139.0	COG1226@1|root,COG1226@2|Bacteria	2|Bacteria	P	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)	kch	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_N
k59_309032_1	765910.MARPU_05100	6.28e-20	87.8	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,1RPBT@1236|Gammaproteobacteria,1WWHF@135613|Chromatiales	135613|Chromatiales	EGP	Major facilitator superfamily	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
k59_309032_2	572477.Alvin_2133	1.92e-70	222.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,1WXNW@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
k59_961957_1	768671.ThimaDRAFT_0873	2.83e-100	307.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGB@1236|Gammaproteobacteria,1X1MI@135613|Chromatiales	135613|Chromatiales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1425239_1	1121468.AUBR01000010_gene2465	1.68e-89	280.0	COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia,42ERZ@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_1599963_1	335543.Sfum_3649	8.38e-21	92.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2WIZQ@28221|Deltaproteobacteria,2MQZI@213462|Syntrophobacterales	28221|Deltaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_961960_1	765420.OSCT_2924	2.79e-54	191.0	COG1009@1|root,COG1009@2|Bacteria,2G5XJ@200795|Chloroflexi,374TZ@32061|Chloroflexia	32061|Chloroflexia	C	PFAM NADH-Ubiquinone oxidoreductase (complex I), chain 5 L domain protein	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
k59_1487636_1	999549.KI421513_gene2327	2.23e-37	138.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2825H@191028|Leisingera	28211|Alphaproteobacteria	G	PQQ-like domain	exaA	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
k59_1487636_2	314231.FP2506_02595	4.86e-20	87.8	COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2U06A@28211|Alphaproteobacteria,2PKZ3@255475|Aurantimonadaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_961966_1	1123392.AQWL01000002_gene1831	5.73e-82	264.0	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VHA3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Phospholipase, patatin family	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_602278_1	933262.AXAM01000094_gene2189	1.22e-93	285.0	COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42NUN@68525|delta/epsilon subdivisions,2WJHN@28221|Deltaproteobacteria,2MHX4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Polysulphide reductase, NrfD	dsrP	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_309047_1	880072.Desac_2884	3.18e-22	92.8	2DE6G@1|root,32U2S@2|Bacteria,1N4FF@1224|Proteobacteria,42TMY@68525|delta/epsilon subdivisions,2WQEV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM ATP synthase I chain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_I
k59_309047_2	644282.Deba_2724	1.64e-05	45.1	COG5336@1|root,COG5336@2|Bacteria	2|Bacteria	C	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex	atpI	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
k59_902988_1	572477.Alvin_2695	3.4e-20	89.7	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,1WVYS@135613|Chromatiales	135613|Chromatiales	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
k59_902988_2	1049564.TevJSym_bh00120	3.55e-36	130.0	2C5QF@1|root,31MIM@2|Bacteria,1QJDJ@1224|Proteobacteria,1THCP@1236|Gammaproteobacteria,1JAA3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4381)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4381
k59_81185_1	322710.Avin_33130	1.71e-38	151.0	COG2109@1|root,COG4206@1|root,COG2109@2|Bacteria,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB	btuB	GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015267,GO:0015318,GO:0015889,GO:0015893,GO:0016020,GO:0016021,GO:0019904,GO:0022803,GO:0022838,GO:0022857,GO:0031224,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	iECB_1328.ECB_03851,iECP_1309.ECP_4183,iSF_1195.SF4048,iS_1188.S3696	Plug,TonB_dep_Rec
k59_902997_1	1108045.GORHZ_213_01180	3.11e-73	240.0	COG1960@1|root,COG1960@2|Bacteria,2GJ4X@201174|Actinobacteria,4GCZI@85026|Gordoniaceae	201174|Actinobacteria	I	Acyl-CoA oxidase	acx	-	1.3.3.6	ko:K00232	ko00071,ko00592,ko01040,ko01100,ko01110,ko01212,ko03320,ko04024,ko04146,map00071,map00592,map01040,map01100,map01110,map01212,map03320,map04024,map04146	M00087,M00113	R01175,R01279,R03777,R03857,R03990,R04751,R04754,R07888,R07892,R07896,R07934,R07950	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	ACOX,Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_661897_1	479431.Namu_3506	1.07e-97	294.0	COG0306@1|root,COG0306@2|Bacteria,2GJHK@201174|Actinobacteria,4ERKR@85013|Frankiales	201174|Actinobacteria	P	phosphate transporter	pitB	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	iNJ661.Rv2281	PHO4
k59_1252668_1	1403819.BATR01000054_gene1698	1.51e-24	104.0	COG4714@1|root,COG4714@2|Bacteria,46WYQ@74201|Verrucomicrobia,2IUN8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Protein of unknown function (DUF2167)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2167
k59_1252668_2	321327.CYA_0024	9.33e-08	52.4	COG0012@1|root,COG0012@2|Bacteria,1G1PW@1117|Cyanobacteria,1GZ1J@1129|Synechococcus	1117|Cyanobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_192240_1	159450.NH14_10665	1.56e-50	176.0	COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2VHA2@28216|Betaproteobacteria,1K1X2@119060|Burkholderiaceae	28216|Betaproteobacteria	V	PFAM secretion protein HlyD family protein	emrA	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23
k59_1599997_2	1137799.GZ78_18485	1.79e-07	55.5	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,1XK5H@135619|Oceanospirillales	135619|Oceanospirillales	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri
k59_903010_1	395965.Msil_2980	7.64e-29	120.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2TT0G@28211|Alphaproteobacteria,3NB0Q@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
k59_776185_1	323261.Noc_2784	1.83e-27	104.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,1RQ0Y@1236|Gammaproteobacteria,1WXYG@135613|Chromatiales	135613|Chromatiales	Q	PFAM Mammalian cell entry related domain protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_1314183_1	765913.ThidrDRAFT_0212	2.9e-52	181.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1WX77@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
k59_1314183_2	523791.Kkor_2012	3.12e-34	127.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1XJ7N@135619|Oceanospirillales	135619|Oceanospirillales	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_192248_2	930169.B5T_03792	2.12e-54	178.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,1RMGR@1236|Gammaproteobacteria,1XHKX@135619|Oceanospirillales	135619|Oceanospirillales	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_133576_2	1380390.JIAT01000012_gene3205	8.98e-05	45.8	COG0604@1|root,COG0604@2|Bacteria,2GMHR@201174|Actinobacteria,4CQBQ@84995|Rubrobacteria	84995|Rubrobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_1660156_1	998674.ATTE01000001_gene3540	1.78e-40	150.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,45ZSF@72273|Thiotrichales	72273|Thiotrichales	E	arginine decarboxylase	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
k59_1660156_2	261292.Nit79A3_2588	1.77e-07	49.3	COG2119@1|root,COG2119@2|Bacteria	2|Bacteria	O	membrane	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
k59_1487678_1	744979.R2A130_1672	9.13e-26	104.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,2TRIC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane transporter protein	MA20_19835	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_1487678_2	1134912.AJTV01000035_gene2346	5.36e-21	90.9	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2TQUE@28211|Alphaproteobacteria,36XY8@31993|Methylocystaceae	28211|Alphaproteobacteria	F	Adenylosuccinate lyase C-terminus	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
k59_543921_1	269796.Rru_A0439	8.19e-33	125.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TSRF@28211|Alphaproteobacteria,2JQ3B@204441|Rhodospirillales	204441|Rhodospirillales	ET	general L-amino acid-binding periplasmic protein AapJ	-	-	-	ko:K09969	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
k59_426387_1	1458427.BAWN01000028_gene1667	5.8e-27	114.0	28HUW@1|root,2Z81F@2|Bacteria,1Q3QA@1224|Proteobacteria,2VK1A@28216|Betaproteobacteria,4AAW9@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1078566_1	102129.Lepto7375DRAFT_2531	4.07e-47	171.0	COG3292@1|root,COG3292@2|Bacteria,1G8JD@1117|Cyanobacteria,1HD0Z@1150|Oscillatoriales	1117|Cyanobacteria	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
k59_1078570_1	909613.UO65_6112	8.22e-85	280.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria,4DYUS@85010|Pseudonocardiales	201174|Actinobacteria	E	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_837593_1	674977.VMC_19520	4.12e-81	258.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,1XSD5@135623|Vibrionales	135623|Vibrionales	P	Arylsulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1011121_1	1304865.JAGF01000001_gene663	3.68e-123	364.0	COG5495@1|root,COG5495@2|Bacteria,2I2F6@201174|Actinobacteria,4F1U1@85016|Cellulomonadaceae	201174|Actinobacteria	S	Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520,Rossmann-like
k59_1541674_1	1122919.KB905552_gene546	1.38e-13	70.1	COG0505@1|root,COG0505@2|Bacteria,1TQ8N@1239|Firmicutes,4H9Z0@91061|Bacilli,26R3K@186822|Paenibacillaceae	91061|Bacilli	F	Belongs to the CarA family	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15510	CPSase_sm_chain,GATase
k59_1541674_2	706587.Desti_2950	1.75e-38	145.0	COG0067@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0070@2|Bacteria,1NZ4D@1224|Proteobacteria,43B3T@68525|delta/epsilon subdivisions,2X6HR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	GXGXG motif	-	-	-	-	-	-	-	-	-	-	-	-	GATase_6,GXGXG
k59_1078571_1	1123368.AUIS01000009_gene2460	2.42e-182	523.0	COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,1RNCS@1236|Gammaproteobacteria,2NCDY@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Belongs to the UPF0061 (SELO) family	-	-	-	-	-	-	-	-	-	-	-	-	UPF0061
k59_1717627_1	990073.ATHU01000001_gene352	8.1e-83	258.0	COG0045@1|root,COG0045@2|Bacteria,1PYM0@1224|Proteobacteria,42NR1@68525|delta/epsilon subdivisions,2YMG6@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	Belongs to the succinate malate CoA ligase beta subunit family	-	-	2.3.3.8	ko:K15231	ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200	M00173	R00352	RC00004,RC00067	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Citrate_bind
k59_903040_1	1045855.DSC_00935	1.57e-67	213.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1X38I@135614|Xanthomonadales	135614|Xanthomonadales	V	Transport permease protein	yadH	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_82285_1	582899.Hden_1865	2.08e-102	309.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2TRIJ@28211|Alphaproteobacteria,3N7JP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain II	algC	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_727341_1	765912.Thimo_2431	3.02e-26	103.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,1SCZX@1236|Gammaproteobacteria,1WZ3C@135613|Chromatiales	135613|Chromatiales	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
k59_1853444_1	768671.ThimaDRAFT_2971	5.47e-52	171.0	COG0850@1|root,COG0850@2|Bacteria,1RHVN@1224|Proteobacteria,1S6K8@1236|Gammaproteobacteria,1WW2J@135613|Chromatiales	135613|Chromatiales	D	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization	minC	-	-	ko:K03610	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	MinC_C,MinC_N
k59_1853444_2	857087.Metme_0712	3.38e-53	174.0	COG2894@1|root,COG2894@2|Bacteria,1MUEU@1224|Proteobacteria,1RNJ0@1236|Gammaproteobacteria,1XEDI@135618|Methylococcales	135618|Methylococcales	D	Belongs to the ParA family	minD	-	-	ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
k59_270440_1	1215114.BBIU01000006_gene962	1.52e-51	182.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	slt	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009274,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	iETEC_1333.ETEC_4747,iPC815.YPO0452	SLT,SLT_L
k59_92184_1	670307.HYPDE_28608	1.11e-104	321.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,3N84S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	acyl-CoA dehydrogenase	mmgC	-	1.3.8.1,1.3.8.7	ko:K00248,ko:K00249,ko:K20035	ko00071,ko00280,ko00410,ko00640,ko00650,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map00920,map01100,map01110,map01120,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754,R11130	RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246,RC03363	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_1325156_1	1521187.JPIM01000038_gene3826	2.43e-20	92.8	COG1501@1|root,COG1501@2|Bacteria,2G5TX@200795|Chloroflexi,376W3@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
k59_1325156_2	1172185.KB911514_gene4139	1.19e-111	341.0	COG1403@1|root,COG1403@2|Bacteria,2I9AH@201174|Actinobacteria,4FXGZ@85025|Nocardiaceae	201174|Actinobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_316559_1	1112217.PPL19_16690	1.14e-13	71.2	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
k59_316559_2	686578.AFFX01000003_gene212	2.57e-27	109.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iUTI89_1310.UTI89_C0772,iZ_1308.Z0993	Aminotran_3
k59_1261985_2	187272.Mlg_2849	4.09e-92	278.0	COG3568@1|root,COG3568@2|Bacteria,1RBWV@1224|Proteobacteria,1S296@1236|Gammaproteobacteria,1X2D7@135613|Chromatiales	135613|Chromatiales	L	Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_433575_2	756272.Plabr_3011	6.43e-05	50.1	COG1409@1|root,COG1409@2|Bacteria,2IXAB@203682|Planctomycetes	203682|Planctomycetes	S	Calcineurin-like phosphoesterase superfamily domain	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Metallophos
k59_844843_1	287986.DV20_14585	5.44e-92	278.0	COG0548@1|root,COG0548@2|Bacteria,2GKDS@201174|Actinobacteria,4DXB3@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_1197656_1	631362.Thi970DRAFT_04731	3.58e-83	272.0	COG0466@1|root,COG0466@2|Bacteria,1NTR5@1224|Proteobacteria,1RPID@1236|Gammaproteobacteria,1WWG2@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1667560_1	768671.ThimaDRAFT_1193	7.1e-43	159.0	COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1WXKG@135613|Chromatiales	135613|Chromatiales	DM	mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM,MscS_porin
k59_36982_1	935839.JAGJ01000002_gene790	1.21e-15	83.2	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4F3T1@85017|Promicromonosporaceae	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1325171_1	1297865.APJD01000003_gene6515	2.37e-64	204.0	COG1230@1|root,COG1230@2|Bacteria,1MUSS@1224|Proteobacteria,2TVQN@28211|Alphaproteobacteria,3JQNG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
k59_1017350_1	1464048.JNZS01000009_gene5917	4e-52	183.0	COG0699@1|root,COG0699@2|Bacteria,2GJX9@201174|Actinobacteria,4D9GS@85008|Micromonosporales	201174|Actinobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_1135749_1	1121413.JMKT01000009_gene2117	7.44e-17	78.2	COG1121@1|root,COG1121@2|Bacteria,1MW47@1224|Proteobacteria,43AE5@68525|delta/epsilon subdivisions,2X64A@28221|Deltaproteobacteria,2MGYQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM ABC transporter related	-	-	-	ko:K09817,ko:K09820,ko:K11710	ko02010,map02010	M00242,M00243,M00319	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
k59_1135749_2	1121405.dsmv_3759	4.69e-69	216.0	COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,42MYM@68525|delta/epsilon subdivisions,2WJAM@28221|Deltaproteobacteria,2MIQY@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM ABC 3 transport family	-	-	-	ko:K09816,ko:K09819	ko02010,map02010	M00242,M00243	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
k59_385680_1	426117.M446_5463	1.2e-126	375.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,1JS39@119045|Methylobacteriaceae	28211|Alphaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_973019_1	1049564.TevJSym_ag00270	2.53e-14	70.9	COG1801@1|root,COG1801@2|Bacteria,1NJGC@1224|Proteobacteria,1SHUQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_973019_3	187272.Mlg_2225	2.1e-44	154.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1WWFJ@135613|Chromatiales	135613|Chromatiales	M	Arabinose 5-phosphate isomerase	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
k59_1087861_1	631362.Thi970DRAFT_03603	1.02e-94	284.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1WWWT@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_1087861_2	765912.Thimo_2383	2.03e-84	259.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1WW6R@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_844863_1	391625.PPSIR1_08671	6.12e-85	259.0	COG0596@1|root,COG0596@2|Bacteria,1MUSF@1224|Proteobacteria,42SZ5@68525|delta/epsilon subdivisions,2WPP5@28221|Deltaproteobacteria,2YZUG@29|Myxococcales	28221|Deltaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_270484_1	1437448.AZRT01000025_gene2729	2.23e-14	76.3	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2TRBX@28211|Alphaproteobacteria,1J1KJ@118882|Brucellaceae	28211|Alphaproteobacteria	M	MacB-like periplasmic core domain	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_270484_2	1499684.CCNP01000025_gene3670	3.88e-08	54.3	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,36DXW@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	lolD	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_914015_1	1713.JOFV01000001_gene1964	1.41e-19	84.7	2E56G@1|root,32ZZ6@2|Bacteria,2GR3Y@201174|Actinobacteria,4F1ID@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_385706_1	1123368.AUIS01000007_gene2819	3.33e-111	330.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,2NCEM@225057|Acidithiobacillales	1236|Gammaproteobacteria	BQ	Histone deacetylase domain	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
k59_1548617_1	1121472.AQWN01000012_gene967	1.36e-22	103.0	COG1061@1|root,COG1061@2|Bacteria,1TQ62@1239|Firmicutes,249TK@186801|Clostridia,2622J@186807|Peptococcaceae	186801|Clostridia	L	type III restriction enzyme, res subunit	-	-	-	-	-	-	-	-	-	-	-	-	HNH,Helicase_C,ResIII
k59_1668175_1	1454010.JEOE01000013_gene2268	3.38e-39	144.0	COG1328@1|root,COG1328@2|Bacteria,2GMGA@201174|Actinobacteria	201174|Actinobacteria	F	Ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
k59_610279_1	1349767.GJA_3981	9.83e-55	185.0	28HU5@1|root,2Z80X@2|Bacteria,1R55N@1224|Proteobacteria,2VI32@28216|Betaproteobacteria,475D2@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	TIGRFAM TIGR03790 family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1262727_1	1121439.dsat_0931	1.3e-11	62.8	COG3599@1|root,COG3599@2|Bacteria,1NCAV@1224|Proteobacteria,42VH6@68525|delta/epsilon subdivisions,2WPC4@28221|Deltaproteobacteria,2MBBV@213115|Desulfovibrionales	28221|Deltaproteobacteria	D	PFAM DivIVA family protein	-	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
k59_1262727_2	997346.HMPREF9374_0503	2.77e-61	198.0	COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,4HAIQ@91061|Bacilli,27BAW@186824|Thermoactinomycetaceae	91061|Bacilli	H	Pantoate-beta-alanine ligase	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
k59_669496_1	265072.Mfla_0131	2.74e-40	149.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2VI1K@28216|Betaproteobacteria,2KMEZ@206350|Nitrosomonadales	206350|Nitrosomonadales	FP	PFAM Ppx GppA phosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
k59_1497228_1	472759.Nhal_2361	1.28e-20	89.4	2952G@1|root,2ZSF9@2|Bacteria,1NFKJ@1224|Proteobacteria,1SDRS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_199814_1	640510.BC1001_4597	4.39e-67	231.0	COG0515@1|root,COG0515@2|Bacteria,1MWVZ@1224|Proteobacteria,2VP13@28216|Betaproteobacteria,1KGF7@119060|Burkholderiaceae	28216|Betaproteobacteria	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384,Pkinase
k59_1725654_1	1121935.AQXX01000068_gene5882	1.85e-28	109.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,1XHGB@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
k59_1725654_2	349124.Hhal_0032	0.000255	45.8	COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,1WY02@135613|Chromatiales	135613|Chromatiales	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
k59_271344_1	765911.Thivi_2999	1.03e-115	347.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1WVY3@135613|Chromatiales	135613|Chromatiales	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1373269_1	556268.OFAG_00021	5.65e-33	124.0	COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2VHHT@28216|Betaproteobacteria,47356@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
k59_1088618_1	935839.JAGJ01000011_gene412	3.96e-68	218.0	COG0438@1|root,COG0438@2|Bacteria,2ICB6@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_669497_1	396588.Tgr7_2324	7.06e-90	270.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,1RMK9@1236|Gammaproteobacteria,1WVZS@135613|Chromatiales	135613|Chromatiales	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_669497_2	1517416.IDAT_06785	8.93e-75	231.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,2QFIW@267893|Idiomarinaceae	1236|Gammaproteobacteria	J	Forms part of the polypeptide exit tunnel	rplD	GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003700,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008428,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030234,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032069,GO:0032074,GO:0032268,GO:0032269,GO:0032991,GO:0032993,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065003,GO:0065007,GO:0065009,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:0098772,GO:0140110,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990904,GO:2000112,GO:2000113,GO:2001141	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_783017_1	67356.KL575589_gene767	3.72e-44	157.0	COG3867@1|root,COG3867@2|Bacteria,2GP0I@201174|Actinobacteria	201174|Actinobacteria	G	PFAM glycosyl hydrolase 53 domain protein	-	-	3.2.1.89	ko:K01224	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_53
k59_1497240_2	95619.PM1_0226640	6.53e-34	119.0	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,1S9AB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the UPF0235 family	yggU	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
k59_1497240_3	1026882.MAMP_01612	7.32e-18	81.3	COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,4615R@72273|Thiotrichales	72273|Thiotrichales	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
k59_915190_1	1279038.KB907337_gene663	3.39e-70	237.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2TRMJ@28211|Alphaproteobacteria,2JPN7@204441|Rhodospirillales	204441|Rhodospirillales	L	ATP-dependent helicase	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_1783650_1	519989.ECTPHS_05435	4.12e-114	339.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,1WX7U@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_199827_1	1225184.ALXE01000025_gene2239	6.68e-06	54.7	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,3VY9S@53335|Pantoea	1236|Gammaproteobacteria	T	Diguanylate cyclase phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_4,PAS_9
k59_1326414_1	439235.Dalk_2921	5.03e-37	129.0	COG2172@1|root,COG2172@2|Bacteria,1N9RD@1224|Proteobacteria,42TUP@68525|delta/epsilon subdivisions,2WQJB@28221|Deltaproteobacteria,2MKT2@213118|Desulfobacterales	28221|Deltaproteobacteria	T	anti-sigma regulatory factor	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
k59_915207_1	1121939.L861_20435	1.31e-81	253.0	COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,1RMF1@1236|Gammaproteobacteria,1XI9B@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis	aguA	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
k59_141277_1	446469.Sked_11100	3.6e-146	423.0	COG0065@1|root,COG0065@2|Bacteria,2GKT7@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_1497254_1	1120705.FG95_03748	1.03e-43	162.0	COG1629@1|root,COG1629@2|Bacteria,1MV8W@1224|Proteobacteria,2U0EP@28211|Alphaproteobacteria,2K0UB@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_1497254_2	392500.Swoo_1143	1.23e-16	79.3	COG0665@1|root,COG0665@2|Bacteria,1MU40@1224|Proteobacteria,1RMJY@1236|Gammaproteobacteria,2QAJQ@267890|Shewanellaceae	1236|Gammaproteobacteria	E	PFAM tryptophan halogenase	prnA	-	1.14.19.9	ko:K14266	ko00404,ko01130,map00404,map01130	M00789,M00790	R09570	RC00949	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_halogenase
k59_1433355_1	876269.ARWA01000001_gene2004	1.02e-32	125.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,3NCSI@45404|Beijerinckiaceae	28211|Alphaproteobacteria	Q	Flavin containing amine oxidoreductase	MA20_01895	-	1.3.99.27	ko:K09845	ko00906,ko01100,map00906,map01100	-	R07517,R07520,R07523,R07534	RC02080	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
k59_1433355_2	574966.KB898656_gene1500	2.14e-38	130.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,1S9DN@1236|Gammaproteobacteria,1XKPR@135619|Oceanospirillales	135619|Oceanospirillales	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3
k59_1433355_3	272630.MexAM1_META1p4809	3.99e-13	68.9	COG0693@1|root,COG0693@2|Bacteria,1MVTT@1224|Proteobacteria,2TT0C@28211|Alphaproteobacteria,1JS34@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM ThiJ PfpI domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
k59_37983_1	110319.CF8_4253	1.4e-41	151.0	COG4584@1|root,COG4584@2|Bacteria,2GM4J@201174|Actinobacteria,4DTTK@85009|Propionibacteriales	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_37983_2	110319.CF8_4252	2.53e-158	446.0	COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria,4DS5V@85009|Propionibacteriales	201174|Actinobacteria	L	IstB-like ATP binding protein	istB	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_1326420_1	388919.SSA_0716	2e-11	67.4	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,4H9M4@91061|Bacilli,1WQZG@1305|Streptococcus sanguinis	91061|Bacilli	S	Domain of unknown function (DUF4131)	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_493038_1	452637.Oter_0373	2.17e-87	271.0	COG1509@1|root,COG1509@2|Bacteria	2|Bacteria	E	lysine 2,3-aminomutase activity	kamA3	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
k59_1262766_1	398579.Spea_3490	1.59e-33	132.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,1RN48@1236|Gammaproteobacteria,2QA9V@267890|Shewanellaceae	1236|Gammaproteobacteria	CE	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
k59_93410_1	34506.g2384	9.02e-50	181.0	COG0688@1|root,KOG2420@2759|Eukaryota,38E13@33154|Opisthokonta,3BDPJ@33208|Metazoa,3CU2W@33213|Bilateria,40DQU@6231|Nematoda,1KWBC@119089|Chromadorea,40SSW@6236|Rhabditida	33208|Metazoa	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine	psd-1	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
k59_845490_1	1134474.O59_002724	3.99e-05	48.5	COG3105@1|root,COG3105@2|Bacteria,1N25P@1224|Proteobacteria,1RW8T@1236|Gammaproteobacteria,1FH78@10|Cellvibrio	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1043)	-	-	-	ko:K09908	-	-	-	-	ko00000	-	-	-	DUF1043
k59_845490_2	1112214.AHIS01000043_gene1844	2.27e-21	87.4	COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,2U945@28211|Alphaproteobacteria,2K4HM@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
k59_93411_1	1249627.D779_2446	1.58e-28	107.0	COG5456@1|root,COG5456@2|Bacteria,1RFTY@1224|Proteobacteria,1S4W0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	PFAM FixH	-	-	-	-	-	-	-	-	-	-	-	-	FixH
k59_93411_2	1049564.TevJSym_ba00350	1.59e-33	130.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J595@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	cation transport ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_610307_1	107636.JQNK01000009_gene1463	2.55e-77	243.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2TS7C@28211|Alphaproteobacteria,36X2F@31993|Methylocystaceae	28211|Alphaproteobacteria	H	Quinolinate phosphoribosyl transferase, N-terminal domain	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
k59_1854746_1	290315.Clim_2386	2.68e-44	149.0	2C8DW@1|root,32RKY@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF3597)	MA20_41375	-	-	-	-	-	-	-	-	-	-	-	DUF3597
k59_1497256_1	1049564.TevJSym_ab01870	3.02e-49	169.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,1J4SM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Permease	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_1497256_2	1121921.KB898708_gene1313	2.48e-25	102.0	COG1714@1|root,COG1714@2|Bacteria,1N2TA@1224|Proteobacteria,1SWZT@1236|Gammaproteobacteria,2PNXZ@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
k59_1497256_3	566466.NOR53_2187	5.46e-32	119.0	COG3198@1|root,COG3198@2|Bacteria,1N75J@1224|Proteobacteria,1SC87@1236|Gammaproteobacteria,1J73G@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	ccoH	-	-	ko:K09926	-	-	-	-	ko00000	-	-	-	FixH
k59_1497256_4	395493.BegalDRAFT_2182	4.67e-191	547.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,4601I@72273|Thiotrichales	72273|Thiotrichales	C	TIGRFAM cytochrome c oxidase accessory protein FixG	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
k59_37997_1	1033743.CAES01000086_gene2998	2.17e-33	129.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,4HAFB@91061|Bacilli,26R27@186822|Paenibacillaceae	91061|Bacilli	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_37997_2	338963.Pcar_2572	8.62e-40	140.0	COG2231@1|root,COG2231@2|Bacteria,1RDJ8@1224|Proteobacteria,42QYA@68525|delta/epsilon subdivisions,2WNGC@28221|Deltaproteobacteria,43SEM@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	endonuclease III	nth	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
k59_1136333_1	1082931.KKY_437	5.96e-23	97.1	COG0395@1|root,COG0395@2|Bacteria,1MUMG@1224|Proteobacteria,2TVBP@28211|Alphaproteobacteria,3N7WZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	aglG	-	-	ko:K10234	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
k59_1136333_2	1284679.HMPREF1626_05355	3.54e-33	126.0	COG0545@1|root,COG0545@2|Bacteria,2IHQC@201174|Actinobacteria,4D855@85005|Actinomycetales	201174|Actinobacteria	G	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
k59_1854762_1	1121403.AUCV01000031_gene2857	8.65e-43	156.0	29GCA@1|root,303A5@2|Bacteria,1NC46@1224|Proteobacteria,431AV@68525|delta/epsilon subdivisions,2WWN5@28221|Deltaproteobacteria,2MNY5@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_728017_1	396588.Tgr7_0357	1.65e-24	94.4	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,1S5WR@1236|Gammaproteobacteria,1WY87@135613|Chromatiales	135613|Chromatiales	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_728017_2	396588.Tgr7_0358	1.8e-255	708.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1WW22@135613|Chromatiales	135613|Chromatiales	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_141298_1	1266914.ATUK01000014_gene2052	1.77e-47	164.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,1WVUX@135613|Chromatiales	135613|Chromatiales	M	Lipid A biosynthesis	lpxL	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_1203428_1	933262.AXAM01000013_gene1280	3.76e-57	186.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,42N5Q@68525|delta/epsilon subdivisions,2WJ8J@28221|Deltaproteobacteria,2MJ20@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_1203428_2	1265505.ATUG01000001_gene3531	2.14e-35	125.0	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,42TRZ@68525|delta/epsilon subdivisions,2WQRI@28221|Deltaproteobacteria,2MKIW@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Belongs to the MraZ family	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
k59_674880_1	675817.VDA_001753	7.67e-91	272.0	COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,1RPKU@1236|Gammaproteobacteria,1XV1E@135623|Vibrionales	135623|Vibrionales	G	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
k59_45197_1	1232437.KL662072_gene1798	3.27e-33	121.0	COG2203@1|root,COG2203@2|Bacteria,1RM3C@1224|Proteobacteria,42T8V@68525|delta/epsilon subdivisions,2WP3I@28221|Deltaproteobacteria,2MKCM@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2
k59_45197_2	96561.Dole_3004	2.27e-37	132.0	COG4117@1|root,COG4117@2|Bacteria,1R5GN@1224|Proteobacteria,42QVP@68525|delta/epsilon subdivisions,2WMT7@28221|Deltaproteobacteria,2MJKZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Prokaryotic cytochrome b561	cbcB	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_983342_1	706439.HMPREF9057_02387	3.3e-15	76.3	COG5401@1|root,COG5401@2|Bacteria,2GJ5Y@201174|Actinobacteria,4D3VY@85005|Actinomycetales	201174|Actinobacteria	S	Lipoprotein LpqB beta-propeller domain	lpqB	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Germane,Gmad1
k59_983342_2	743718.Isova_2357	9.66e-36	134.0	COG5002@1|root,COG5002@2|Bacteria,2GJ2D@201174|Actinobacteria,4F3ET@85017|Promicromonosporaceae	201174|Actinobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	mtrB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	2.7.13.3	ko:K07636,ko:K07654	ko02020,map02020	M00434,M00461	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_983347_1	522306.CAP2UW1_2085	1.55e-31	119.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,1KQA5@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	P	phosphate transporter	-	-	-	ko:K03306,ko:K16322	-	-	-	-	ko00000,ko02000	2.A.20,2.A.20.1	-	-	PHO4
k59_1612541_1	1134912.AJTV01000053_gene3694	5.75e-116	353.0	COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,2TSQU@28211|Alphaproteobacteria,36ZIN@31993|Methylocystaceae	28211|Alphaproteobacteria	S	von Willebrand factor type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	DUF3520,VWA,vWF_A
k59_1502951_1	494419.ALPM01000056_gene2955	3.69e-47	167.0	COG1403@1|root,COG1403@2|Bacteria,2I9AH@201174|Actinobacteria,1WAIH@1268|Micrococcaceae	201174|Actinobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_102364_1	1108045.GORHZ_044_00010	8.87e-90	280.0	COG5421@1|root,COG5421@2|Bacteria,2GK2A@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_924295_1	42256.RradSPS_0173	6.39e-45	164.0	COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria,4CPGW@84995|Rubrobacteria	84995|Rubrobacteria	G	Protein of unknown function (DUF3417)	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_1022227_1	177437.HRM2_25960	1.02e-46	159.0	COG0398@1|root,COG0398@2|Bacteria,1RBAE@1224|Proteobacteria,42QZX@68525|delta/epsilon subdivisions,2WN5T@28221|Deltaproteobacteria,2MJPX@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function, DUF547	-	-	-	-	-	-	-	-	-	-	-	-	DUF547
k59_1022227_2	1499967.BAYZ01000190_gene3817	1.98e-57	192.0	COG1249@1|root,COG1249@2|Bacteria	2|Bacteria	C	cell redox homeostasis	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1268556_1	765911.Thivi_2320	2.65e-67	217.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,1WWCK@135613|Chromatiales	135613|Chromatiales	M	Peptidoglycan polymerase that is essential for cell division	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_1335578_1	383381.EH30_00745	1.68e-32	128.0	COG2866@1|root,COG2866@2|Bacteria,1R490@1224|Proteobacteria,2U9Z3@28211|Alphaproteobacteria,2K5PY@204457|Sphingomonadales	204457|Sphingomonadales	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_1863902_1	713587.THITH_09035	2.66e-87	263.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1WW0K@135613|Chromatiales	135613|Chromatiales	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_498323_1	270374.MELB17_06644	9.86e-13	68.9	COG0697@1|root,COG0697@2|Bacteria,1QSKQ@1224|Proteobacteria,1RYG1@1236|Gammaproteobacteria,466BE@72275|Alteromonadaceae	1236|Gammaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	EamA
k59_498323_2	305700.B447_05323	6.3e-33	127.0	COG1232@1|root,COG1232@2|Bacteria,1NQUH@1224|Proteobacteria,2VJV1@28216|Betaproteobacteria,2KVAB@206389|Rhodocyclales	206389|Rhodocyclales	H	squalene-associated FAD-dependent desaturase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_983394_1	1243664.CAVL020000050_gene4719	1.5e-20	92.4	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,4HEAN@91061|Bacilli,1ZQ9E@1386|Bacillus	91061|Bacilli	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
k59_439578_1	1408452.JAGZ01000003_gene5107	1.43e-19	93.6	COG0370@1|root,COG0370@2|Bacteria,2GTV2@201174|Actinobacteria,235FD@1762|Mycobacteriaceae	201174|Actinobacteria	P	Ferrous iron transport protein B C terminus	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoA,FeoB_C,FeoB_N,Gate
k59_498328_1	1523503.JPMY01000005_gene2021	3.86e-31	127.0	COG2206@1|root,COG2206@2|Bacteria,1MV37@1224|Proteobacteria,1RM9C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG0840 Methyl-accepting chemotaxis protein	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,dCache_1
k59_733483_1	478741.JAFS01000002_gene307	4.69e-62	210.0	COG0465@1|root,COG0465@2|Bacteria,46SB7@74201|Verrucomicrobia,37GBM@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
k59_45230_1	1245475.ANAE01000165_gene2273	6.48e-72	243.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4EHEN@85012|Streptosporangiales	201174|Actinobacteria	M	Transglycosylase	pon1	-	-	-	-	-	-	-	-	-	-	-	PASTA,Transgly,Transpeptidase
k59_1268572_2	1340434.AXVA01000003_gene2156	1.21e-62	208.0	COG2041@1|root,COG2041@2|Bacteria,1UHJ9@1239|Firmicutes,4HDCA@91061|Bacilli,1ZD4K@1386|Bacillus	91061|Bacilli	S	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
k59_45235_1	1121878.AUGL01000016_gene3187	4.68e-20	95.1	COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a)	lpoA	GO:0000270,GO:0003674,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	-	ko:K07121	-	-	-	-	ko00000	-	-	-	LppC
k59_146663_1	743718.Isova_0073	1.97e-70	241.0	COG1403@1|root,COG1403@2|Bacteria,2HAHI@201174|Actinobacteria,4F3G4@85017|Promicromonosporaceae	201174|Actinobacteria	V	Domain of unknown function (DUF222)	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_146663_2	471853.Bcav_2780	1.94e-173	498.0	COG0477@1|root,COG2814@2|Bacteria,2GJK6@201174|Actinobacteria	201174|Actinobacteria	EGP	Drug resistance transporter, bcr cfla subfamily	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_146663_3	219305.MCAG_02222	5.67e-30	114.0	COG1309@1|root,COG1309@2|Bacteria,2I31S@201174|Actinobacteria,4DE3F@85008|Micromonosporales	201174|Actinobacteria	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
k59_1863954_1	314225.ELI_03375	1.5e-05	46.2	29QFW@1|root,30BF9@2|Bacteria,1NNM7@1224|Proteobacteria,2UM5Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_146676_1	1116472.MGMO_7c00450	1.16e-51	179.0	COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,1RMH4@1236|Gammaproteobacteria,1XDPA@135618|Methylococcales	135618|Methylococcales	T	Histidine kinase	-	-	2.7.13.3	ko:K15011	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c
k59_733502_1	913325.N799_08840	2.39e-67	231.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1X4MI@135614|Xanthomonadales	135614|Xanthomonadales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_1140822_1	396588.Tgr7_3316	1.07e-85	271.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1WXBH@135613|Chromatiales	135613|Chromatiales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_1335641_1	713586.KB900536_gene2597	1.99e-56	189.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1WW09@135613|Chromatiales	135613|Chromatiales	CH	Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	-	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_1612602_1	748658.KB907313_gene2198	1.07e-76	248.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1WVW2@135613|Chromatiales	135613|Chromatiales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_205249_1	1173024.KI912149_gene4979	1.05e-63	219.0	COG2319@1|root,COG2372@1|root,COG2319@2|Bacteria,COG2372@2|Bacteria	2|Bacteria	C	response to copper ion	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082,KAP_NTPase,SASA,SLH,WD40
k59_102455_1	1353528.DT23_03345	3.36e-35	126.0	28I8Y@1|root,2Z8BR@2|Bacteria,1MXN1@1224|Proteobacteria,2TRAQ@28211|Alphaproteobacteria,2XKZE@285107|Thioclava	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638
k59_102455_2	411684.HPDFL43_09512	2.34e-69	212.0	28NR0@1|root,2ZBQD@2|Bacteria,1RA2I@1224|Proteobacteria,2U5BA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Nucleoside 2-deoxyribosyltransferase YtoQ	ytoQ	-	-	-	-	-	-	-	-	-	-	-	Nuc_deoxyri_tr3
k59_1022268_1	367299.JOEE01000012_gene3247	4.1e-109	330.0	COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria,4FGN4@85021|Intrasporangiaceae	201174|Actinobacteria	E	GMC oxidoreductase	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_556908_2	1286106.MPL1_08539	4.91e-68	214.0	COG4659@1|root,COG4659@2|Bacteria,1RDEP@1224|Proteobacteria,1RPAD@1236|Gammaproteobacteria,460RQ@72273|Thiotrichales	72273|Thiotrichales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
k59_556908_3	748658.KB907313_gene2377	6.02e-57	183.0	COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,1RMEH@1236|Gammaproteobacteria,1WWBK@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
k59_1438583_1	631362.Thi970DRAFT_02374	2.36e-68	232.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WW1G@135613|Chromatiales	135613|Chromatiales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1203490_1	1469245.JFBG01000077_gene318	9.06e-143	432.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WW6D@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_102457_1	765912.Thimo_0666	3.47e-49	164.0	COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,1RMS7@1236|Gammaproteobacteria,1WWCG@135613|Chromatiales	135613|Chromatiales	C	PFAM Phosphoribulokinase uridine kinase	-	-	2.7.1.19	ko:K00855	ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200	M00165,M00166	R01523	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
k59_1268596_1	472759.Nhal_3177	6.1e-288	833.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales	135613|Chromatiales	E	glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_733517_1	123899.JPQP01000004_gene352	5.39e-55	193.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,3T39S@506|Alcaligenaceae	28216|Betaproteobacteria	Q	ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_278234_1	1304865.JAGF01000001_gene3520	3.46e-37	129.0	COG0346@1|root,COG0346@2|Bacteria,2IRGK@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_278234_2	1406840.Q763_12860	9.75e-19	90.1	COG2819@1|root,COG2819@2|Bacteria,4NGJB@976|Bacteroidetes,1HYW6@117743|Flavobacteriia,2NUG8@237|Flavobacterium	976|Bacteroidetes	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_1022811_1	439235.Dalk_0883	8.09e-147	427.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MDC@68525|delta/epsilon subdivisions,2WJM7@28221|Deltaproteobacteria,2MHWR@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.102,2.6.1.109	ko:K13010,ko:K19715	ko00520,map00520	-	R10460,R11395	RC00006,RC00160,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
k59_1674166_1	698769.JFBD01000019_gene2050	4.37e-12	67.4	COG0789@1|root,COG0789@2|Bacteria,1UZBH@1239|Firmicutes,4I2Z5@91061|Bacilli,4C6Y5@84406|Virgibacillus	91061|Bacilli	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
k59_103571_1	1266909.AUAG01000004_gene2150	7.14e-24	97.1	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1WWV1@135613|Chromatiales	135613|Chromatiales	L	PFAM Endonuclease Exonuclease phosphatase	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_103571_2	391615.ABSJ01000026_gene121	4.34e-43	152.0	2CIBN@1|root,2Z8JT@2|Bacteria,1R902@1224|Proteobacteria,1RXPM@1236|Gammaproteobacteria,1J8X1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1141357_1	522306.CAP2UW1_3536	5.3e-25	101.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_1141357_2	1454004.AW11_03688	1.06e-61	194.0	COG3439@1|root,COG3439@2|Bacteria,1MZ38@1224|Proteobacteria,2VVUF@28216|Betaproteobacteria	28216|Betaproteobacteria	V	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_397106_1	33178.CADATEAP00000117	2.69e-27	112.0	28JUJ@1|root,2QS8H@2759|Eukaryota,3A02S@33154|Opisthokonta,3P04P@4751|Fungi,3QTEX@4890|Ascomycota,20CWT@147545|Eurotiomycetes,3SAY9@5042|Eurotiales	4751|Fungi	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_397106_2	1469607.KK073768_gene1998	1.05e-46	157.0	COG2321@1|root,COG2321@2|Bacteria,1G20J@1117|Cyanobacteria,1HRR5@1161|Nostocales	1117|Cyanobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
k59_323189_2	1437882.AZRU01000002_gene2424	1.48e-27	110.0	COG1773@1|root,COG1773@2|Bacteria,1MV2U@1224|Proteobacteria,1S2ZY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	PFAM HupH hydrogenase expression protein, C-terminal conserved region	hyaF	-	-	ko:K03618	-	-	-	-	ko00000	-	-	-	HupH_C,Rubredoxin
k59_1788676_1	446471.Xcel_3220	6.03e-05	48.5	COG1276@1|root,COG3336@1|root,COG1276@2|Bacteria,COG3336@2|Bacteria,2GKIR@201174|Actinobacteria,4F3WY@85017|Promicromonosporaceae	201174|Actinobacteria	P	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	ko:K02351,ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	Caa3_CtaG,CopD
k59_1336865_1	1223542.GM1_035_00250	1.56e-75	238.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4GBIN@85026|Gordoniaceae	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	sugC	GO:0006810,GO:0008150,GO:0008643,GO:0009405,GO:0015766,GO:0015771,GO:0015772,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051179,GO:0051234,GO:0051704,GO:0071702	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran
k59_1674180_1	1123400.KB904780_gene1854	4.54e-53	184.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,45ZSX@72273|Thiotrichales	72273|Thiotrichales	NU	Type II IV secretion system protein	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
k59_675640_2	1379698.RBG1_1C00001G0407	4.35e-36	133.0	COG0823@1|root,COG0823@2|Bacteria,2NQA4@2323|unclassified Bacteria	2|Bacteria	U	Periplasmic component of the Tol biopolymer transport system	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PA,PD40,PDZ_2,Peptidase_M28
k59_1674181_2	237368.SCABRO_02889	2.44e-15	79.0	28PW7@1|root,32EDN@2|Bacteria,2J3ED@203682|Planctomycetes	2|Bacteria	S	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
k59_323202_1	1249627.D779_4051	9.95e-27	108.0	COG2067@1|root,COG2067@2|Bacteria,1REWT@1224|Proteobacteria,1T2F4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_205950_1	94624.Bpet4125	2.6e-31	128.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,3T2YF@506|Alcaligenaceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	iorB	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1336882_1	232346.JHQL01000002_gene1298	2.05e-07	52.8	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,MASE3,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k59_1336882_2	1123393.KB891317_gene2281	4.7e-39	138.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,2VJQQ@28216|Betaproteobacteria,1KRB1@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine	-	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
k59_851320_1	572477.Alvin_1727	2.02e-126	374.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1WWEZ@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1094983_1	399739.Pmen_1530	5.46e-42	152.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,1RNY6@1236|Gammaproteobacteria,1YHPW@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	Major Facilitator Superfamily	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	MFS_1,TLC
k59_925583_1	1385520.N802_03005	3.71e-36	124.0	2DPHS@1|root,3324E@2|Bacteria,2GT39@201174|Actinobacteria,4FHUC@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_925583_2	1385520.N802_03000	2.29e-67	206.0	COG4113@1|root,COG4113@2|Bacteria,2GR4U@201174|Actinobacteria,4FHJX@85021|Intrasporangiaceae	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
k59_1141377_1	284031.JNXD01000049_gene7161	5.85e-09	60.5	COG4584@1|root,COG4584@2|Bacteria,2GM4J@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1336891_1	1114964.L485_17825	1.5e-37	137.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2TQQC@28211|Alphaproteobacteria,2K0C2@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_1336891_2	631454.N177_3369	2.63e-09	58.5	COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2TSE9@28211|Alphaproteobacteria,1JNZH@119043|Rhodobiaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1439279_1	1035308.AQYY01000001_gene1470	5.18e-107	322.0	COG0427@1|root,COG0427@2|Bacteria,1TPHC@1239|Firmicutes,247V0@186801|Clostridia,260IW@186807|Peptococcaceae	186801|Clostridia	C	PFAM Acetyl-CoA hydrolase transferase	cat1	-	2.8.3.18	ko:K18118,ko:K18122	ko00020,ko00620,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00650,map01100,map01110,map01120,map01130,map01200	M00009,M00011	R05336,R10343	RC00012,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
k59_287163_2	498761.HM1_1340	4.93e-36	137.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia	186801|Clostridia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1101406_2	930166.CD58_22635	2.18e-41	145.0	COG0412@1|root,COG0412@2|Bacteria,1RCWF@1224|Proteobacteria,1RY38@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
k59_287168_1	376733.IT41_19625	9.04e-15	76.3	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria,2PY8S@265|Paracoccus	28211|Alphaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_681620_1	396588.Tgr7_2800	6.38e-38	140.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,1RMSZ@1236|Gammaproteobacteria,1X2PU@135613|Chromatiales	135613|Chromatiales	EGP	Drug resistance transporter Bcr CflA subfamily	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_934361_1	7719.XP_002127609.1	2.89e-07	57.8	COG3177@1|root,KOG3824@2759|Eukaryota,38B91@33154|Opisthokonta,3BDIM@33208|Metazoa,3CV6D@33213|Bilateria,483DR@7711|Chordata	33208|Metazoa	S	protein adenylyltransferase activity	FICD	GO:0000166,GO:0003008,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005737,GO:0005783,GO:0005789,GO:0005886,GO:0006464,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006836,GO:0006950,GO:0006952,GO:0007600,GO:0007601,GO:0007610,GO:0007632,GO:0008081,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009416,GO:0009581,GO:0009582,GO:0009583,GO:0009584,GO:0009605,GO:0009607,GO:0009617,GO:0009628,GO:0009966,GO:0009987,GO:0010646,GO:0012505,GO:0015696,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0017076,GO:0018117,GO:0018175,GO:0019538,GO:0023051,GO:0030176,GO:0030544,GO:0030554,GO:0031072,GO:0031224,GO:0031227,GO:0031967,GO:0031975,GO:0031984,GO:0032501,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034260,GO:0034976,GO:0035639,GO:0036094,GO:0036211,GO:0042175,GO:0042578,GO:0042742,GO:0042802,GO:0042803,GO:0043086,GO:0043087,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0044601,GO:0044602,GO:0044603,GO:0045117,GO:0046983,GO:0048519,GO:0048583,GO:0050789,GO:0050790,GO:0050794,GO:0050829,GO:0050877,GO:0050896,GO:0050906,GO:0050908,GO:0050953,GO:0050962,GO:0051087,GO:0051179,GO:0051234,GO:0051336,GO:0051346,GO:0051606,GO:0051608,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0065009,GO:0070566,GO:0070733,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0080134,GO:0080135,GO:0097159,GO:0097367,GO:0098542,GO:0098827,GO:0140096,GO:1900101,GO:1901265,GO:1901363,GO:1901564,GO:1903894,GO:1905897	-	-	-	-	-	-	-	-	-	-	Fic
k59_1737391_1	1122599.AUGR01000006_gene3911	4.88e-82	260.0	COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria,1S01Y@1236|Gammaproteobacteria,1XIYH@135619|Oceanospirillales	135619|Oceanospirillales	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4
k59_287171_1	996637.SGM_0749	2.87e-27	113.0	COG1609@1|root,COG1609@2|Bacteria,2GJ5Q@201174|Actinobacteria	201174|Actinobacteria	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
k59_1510246_1	367299.JOEE01000001_gene2057	1.58e-29	111.0	COG0839@1|root,COG0839@2|Bacteria,2GKRS@201174|Actinobacteria,4FFRB@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_1510246_2	313589.JNB_08979	1.16e-51	164.0	COG0713@1|root,COG0713@2|Bacteria,2IKV7@201174|Actinobacteria,4FGWN@85021|Intrasporangiaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
k59_1510246_3	367299.JOEE01000001_gene2059	9.92e-59	199.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4FEJ4@85021|Intrasporangiaceae	201174|Actinobacteria	CP	NADH ubiquinone oxidoreductase subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_563308_1	1304275.C41B8_14975	3.42e-60	205.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,1RN57@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	ABC transporter substrate-binding protein	oppA	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
k59_1146578_1	1198232.CYCME_0874	7.42e-12	63.2	COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,1S6AJ@1236|Gammaproteobacteria,4616R@72273|Thiotrichales	72273|Thiotrichales	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
k59_857595_1	351348.Maqu_2455	4.07e-75	235.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,465NF@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105	Glycos_transf_4,MraY_sig1
k59_857595_2	925775.XVE_1841	8.68e-49	174.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1X3IV@135614|Xanthomonadales	135614|Xanthomonadales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1385853_1	1232437.KL661986_gene3674	3.66e-91	268.0	COG5418@1|root,COG5418@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1619829_1	1089552.KI911559_gene3333	9.11e-99	298.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2JPAE@204441|Rhodospirillales	204441|Rhodospirillales	I	Belongs to the thiolase family	phbA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_622592_1	1198114.AciX9_1709	1.48e-49	170.0	COG0573@1|root,COG0573@2|Bacteria,3Y42Y@57723|Acidobacteria,2JIJN@204432|Acidobacteriia	204432|Acidobacteriia	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_288227_1	751994.AGIG01000028_gene1933	3.32e-103	308.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,1RYAQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_407140_2	743299.Acife_0255	6.53e-88	265.0	COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,1RRR0@1236|Gammaproteobacteria,2NCB2@225057|Acidithiobacillales	225057|Acidithiobacillales	O	PFAM 20S proteasome, A and B subunits	-	-	-	ko:K07395	-	-	-	-	ko00000	-	-	-	Proteasome
k59_1210351_1	1214101.BN159_1638	2.09e-98	308.0	COG3669@1|root,COG3669@2|Bacteria,2HUEI@201174|Actinobacteria	201174|Actinobacteria	G	Alpha-L-fucosidase	-	-	-	-	-	-	-	-	-	-	-	-	Alpha_L_fucos,RicinB_lectin_2
k59_1794405_1	1713.JOFV01000013_gene960	2.32e-17	82.0	2BK9Y@1|root,32EQ4@2|Bacteria,2HXWS@201174|Actinobacteria,4F1E1@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1794405_2	1122933.JNIY01000005_gene1494	1.22e-78	246.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4F13Q@85016|Cellulomonadaceae	201174|Actinobacteria	M	PFAM glycosyl transferase group 1	glgA	-	2.4.1.342	ko:K16148	ko00500,ko01100,map00500,map01100	-	R02421,R11530	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
k59_1680567_1	1379270.AUXF01000002_gene1567	7.5e-20	96.3	COG0515@1|root,COG0515@2|Bacteria,1ZUCF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_935248_2	225937.HP15_238	1.07e-08	62.4	COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,1RNJY@1236|Gammaproteobacteria,467C6@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	enzyme of heme biosynthesis	hemX	-	2.1.1.107,4.2.1.75	ko:K02496,ko:K13543	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b3803,iBWG_1329.BWG_3482,iECDH1ME8569_1439.ECDH1ME8569_3682,iECUMN_1333.ECUMN_4327,iECs_1301.ECs4733,iEcDH1_1363.EcDH1_4176,iJO1366.b3803,iJR904.b3803,iPC815.YPO3851,iUMN146_1321.UM146_19140,iY75_1357.Y75_RS18060,iZ_1308.Z5317	HemX
k59_1511002_2	1417296.U879_08090	3.06e-42	147.0	COG1150@1|root,COG1150@2|Bacteria,1R874@1224|Proteobacteria,2U3QM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_9
k59_1276802_1	1187848.AJYQ01000110_gene418	3.8e-38	135.0	2CAAY@1|root,32RR1@2|Bacteria,1P2IE@1224|Proteobacteria,1SR7R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1561642_1	1454004.AW11_03987	5.06e-36	127.0	2E9HQ@1|root,333QT@2|Bacteria,1N8T3@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1561642_2	585531.HMPREF0063_10642	2.29e-18	87.0	COG0078@1|root,COG0078@2|Bacteria,2GJ6H@201174|Actinobacteria,4DNNE@85009|Propionibacteriales	201174|Actinobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_564010_1	1249627.D779_2579	1.08e-98	294.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,1RR9N@1236|Gammaproteobacteria,1WX27@135613|Chromatiales	135613|Chromatiales	S	permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
k59_1619850_1	765910.MARPU_02630	7.7e-127	375.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1WWJ8@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_1210363_1	1713.JOFV01000001_gene1905	1.76e-30	124.0	COG2976@1|root,COG2976@2|Bacteria,2GNIS@201174|Actinobacteria,4F28B@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein of unknown function (DUF4012)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4012
k59_55415_1	1322246.BN4_11700	1.69e-62	207.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,42M94@68525|delta/epsilon subdivisions,2WINB@28221|Deltaproteobacteria,2M8JZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_935267_1	243233.MCA2491	2.31e-05	50.8	COG3147@1|root,COG3147@2|Bacteria,1NGE3@1224|Proteobacteria,1SCGC@1236|Gammaproteobacteria,1XFK1@135618|Methylococcales	135618|Methylococcales	S	Sporulation related domain	-	-	-	ko:K03749	-	-	-	-	ko00000	-	-	-	SPOR
k59_288256_1	1187851.A33M_4207	4.62e-91	275.0	COG0543@1|root,COG0543@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	gltA	-	1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14	ko:K00266,ko:K00528,ko:K02823	ko00240,ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248,R10159	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,Fer4_20,NAD_binding_1,Pyr_redox_2
k59_740994_1	438753.AZC_2870	4.05e-23	101.0	COG4177@1|root,COG4177@2|Bacteria,1QVYX@1224|Proteobacteria,2U219@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_740994_2	335543.Sfum_2143	3.54e-26	105.0	COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,42YQS@68525|delta/epsilon subdivisions,2WUCI@28221|Deltaproteobacteria,2MRS1@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_1385885_1	1255043.TVNIR_0201	3.07e-50	166.0	2E25Q@1|root,32XCG@2|Bacteria,1N1B8@1224|Proteobacteria,1S963@1236|Gammaproteobacteria,1WZ2N@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1385885_2	768671.ThimaDRAFT_4548	8.14e-138	397.0	COG1073@1|root,COG1073@2|Bacteria,1R76C@1224|Proteobacteria,1RR34@1236|Gammaproteobacteria,1X0RN@135613|Chromatiales	135613|Chromatiales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
k59_1875242_1	1288494.EBAPG3_510	1.92e-91	287.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,372IA@32003|Nitrosomonadales	28216|Betaproteobacteria	V	ABC transporter transmembrane region	atm1	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_113633_1	38833.XP_003062943.1	4.99e-22	98.2	COG1999@1|root,KOG2792@2759|Eukaryota,37M1T@33090|Viridiplantae,34HSX@3041|Chlorophyta	3041|Chlorophyta	C	SCO1/SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
k59_1738106_1	671143.DAMO_1933	1.1e-31	127.0	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_622630_1	504728.K649_13245	2.92e-12	72.0	COG1470@1|root,COG5184@1|root,COG1470@2|Bacteria,COG5184@2|Bacteria,1WJQH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	DZ	PFAM Regulator of chromosome condensation (RCC1)	-	-	-	-	-	-	-	-	-	-	-	-	RCC1
k59_1029287_1	1167006.UWK_02492	1.47e-101	310.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2WIZQ@28221|Deltaproteobacteria,2MHQ6@213118|Desulfobacterales	28221|Deltaproteobacteria	E	D-isomer specific 2-hydroxyacid dehydrogenase catalytic	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_1511034_1	498211.CJA_0077	3.39e-35	128.0	COG0835@1|root,COG0835@2|Bacteria,1RCIR@1224|Proteobacteria,1S61F@1236|Gammaproteobacteria,1FGH3@10|Cellvibrio	1236|Gammaproteobacteria	NT	Two component signalling adaptor domain	pilI	-	-	ko:K02659	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	CheW
k59_1276827_1	999141.GME_03462	1.07e-95	294.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1XHA4@135619|Oceanospirillales	135619|Oceanospirillales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_55448_1	670307.HYPDE_36873	7.32e-80	267.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,3N6A5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Glutamate synthase	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_994557_1	880072.Desac_2309	3.56e-100	309.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2WJ2N@28221|Deltaproteobacteria,2MQSY@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_1561679_1	981384.AEYW01000001_gene1602	6.57e-48	170.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_1102267_1	1123371.ATXH01000019_gene601	5.72e-82	253.0	COG0535@1|root,COG0535@2|Bacteria,2GH90@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Iron-sulfur cluster-binding domain	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_994561_1	395019.Bmul_2674	1.68e-06	52.8	COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,2VJ44@28216|Betaproteobacteria,1K0NB@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	pqiB	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_994561_2	243233.MCA0364	7.42e-08	55.1	COG3009@1|root,COG3009@2|Bacteria,1N8BW@1224|Proteobacteria,1SHZZ@1236|Gammaproteobacteria,1XF9Y@135618|Methylococcales	135618|Methylococcales	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K09857	-	-	-	-	ko00000	-	-	-	ABC_trans_aux
k59_1147216_1	443143.GM18_1435	8.41e-102	306.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42M4C@68525|delta/epsilon subdivisions,2WJ1Q@28221|Deltaproteobacteria,43T8C@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	degT	-	2.6.1.98	ko:K13017	ko00520,map00520	-	R10141	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
k59_1147216_2	1249627.D779_0234	5.71e-50	170.0	COG0438@1|root,COG0438@2|Bacteria,1QF9A@1224|Proteobacteria,1RMDT@1236|Gammaproteobacteria,1WW1R@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_1385901_2	1122197.ATWI01000008_gene2695	4.14e-18	79.0	COG1555@1|root,COG1555@2|Bacteria,1N6Q3@1224|Proteobacteria,1SC7U@1236|Gammaproteobacteria,4693D@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG1555 DNA uptake protein and related DNA-binding proteins	comEA	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3
k59_1385901_3	582744.Msip34_1100	5.16e-96	287.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2VJRD@28216|Betaproteobacteria,2KM96@206350|Nitrosomonadales	206350|Nitrosomonadales	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_1385904_1	110319.CF8_3263	2.98e-42	155.0	COG1263@1|root,COG1264@1|root,COG2190@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,COG2190@2|Bacteria,2GKPM@201174|Actinobacteria,4DT51@85009|Propionibacteriales	201174|Actinobacteria	G	Phosphotransferase system, EIIC	nagE	-	2.7.1.193	ko:K02802,ko:K02803,ko:K02804	ko00520,ko02060,map00520,map02060	M00267	R05199	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7	-	-	PTS_EIIA_1,PTS_EIIB,PTS_EIIC
k59_55463_1	1121935.AQXX01000097_gene1703	0.000597	41.2	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1XHN9@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_55463_2	349124.Hhal_0431	2.54e-77	239.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1WXAD@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_1511056_1	270374.MELB17_17263	1.79e-17	84.3	COG0438@1|root,COG0438@2|Bacteria,1NA28@1224|Proteobacteria,1RQBV@1236|Gammaproteobacteria,4668K@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0438 Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3524,Glyco_trans_1_4,Glycos_transf_1
k59_329872_1	335543.Sfum_0259	5.89e-99	308.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2MR9G@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
k59_622661_1	1443665.JACA01000003_gene594	3.17e-21	96.7	COG1520@1|root,COG2866@1|root,COG2931@1|root,COG3209@1|root,COG3210@1|root,COG3391@1|root,COG4886@1|root,COG1520@2|Bacteria,COG2866@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,COG4886@2|Bacteria,4PKBQ@976|Bacteroidetes,1IJ7S@117743|Flavobacteriia	976|Bacteroidetes	M	SPTR CHU large protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF5011,HYR,SprB
k59_994585_1	935839.JAGJ01000010_gene253	3.3e-44	149.0	COG0778@1|root,COG0778@2|Bacteria,2I0M5@201174|Actinobacteria,4F4PS@85017|Promicromonosporaceae	201174|Actinobacteria	C	Domain of unknown function (DUF1918)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1876,DUF1918
k59_994585_2	446466.Cfla_2118	1.35e-81	269.0	COG1391@1|root,COG1391@2|Bacteria,2GJ91@201174|Actinobacteria,4F0U3@85016|Cellulomonadaceae	201174|Actinobacteria	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_935335_1	631362.Thi970DRAFT_00829	9.19e-14	70.1	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RQBM@1236|Gammaproteobacteria,1WWV0@135613|Chromatiales	135613|Chromatiales	E	aminotransferase class I and II	-	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_935335_2	631362.Thi970DRAFT_00830	1.41e-92	283.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1WWHB@135613|Chromatiales	135613|Chromatiales	E	homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
k59_741052_1	1121920.AUAU01000017_gene1239	1.31e-54	189.0	COG0281@1|root,COG0281@2|Bacteria,3Y43V@57723|Acidobacteria	57723|Acidobacteria	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
k59_407248_1	985665.HPL003_22465	0.00091	42.7	COG2963@1|root,COG2963@2|Bacteria,1V9ZX@1239|Firmicutes,4HKN9@91061|Bacilli,26Z90@186822|Paenibacillaceae	91061|Bacilli	L	COG2963 Transposase and inactivated derivatives	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1875307_1	926569.ANT_09980	7.11e-79	262.0	COG0085@1|root,COG0085@2|Bacteria,2G5VH@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_564098_1	998674.ATTE01000001_gene2587	1.07e-96	310.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,45ZPA@72273|Thiotrichales	72273|Thiotrichales	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_741062_1	314275.MADE_1009720	2.22e-64	209.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,464SU@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003872,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005945,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008443,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019200,GO:0019318,GO:0019320,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035639,GO:0036094,GO:0042802,GO:0042866,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046365,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0061615,GO:0061695,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494,GO:1990234	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	iNRG857_1313.NRG857_19550	PFK
k59_154163_1	439235.Dalk_3410	4.21e-18	83.6	COG0189@1|root,COG0189@2|Bacteria,1RH7D@1224|Proteobacteria,42SDD@68525|delta/epsilon subdivisions,2WPGS@28221|Deltaproteobacteria,2MKA2@213118|Desulfobacterales	28221|Deltaproteobacteria	HJ	PFAM RimK domain protein ATP-grasp	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
k59_154163_2	1304885.AUEY01000016_gene3065	9.33e-45	147.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,42U6P@68525|delta/epsilon subdivisions,2WQ00@28221|Deltaproteobacteria,2MKG2@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM HNH endonuclease	-	-	-	ko:K07451	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HNH_5
k59_793208_1	525904.Tter_0583	1.39e-37	135.0	2AZDP@1|root,31RMA@2|Bacteria,2NRKB@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF4230)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4230
k59_1102309_1	887062.HGR_08519	3.96e-86	262.0	COG0656@1|root,COG0656@2|Bacteria,1MUH2@1224|Proteobacteria,2VJNQ@28216|Betaproteobacteria,4ACK8@80864|Comamonadaceae	28216|Betaproteobacteria	S	Aldo keto	-	-	1.1.1.21	ko:K00011	ko00040,ko00051,ko00052,ko00561,ko00790,ko01100,map00040,map00051,map00052,map00561,map00790,map01100	-	R01036,R01041,R01093,R01095,R01431,R01758,R01759,R01787,R02531,R02577,R04285,R11764	RC00099,RC00108,RC00133,RC00205,RC00670	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
k59_1875328_1	518766.Rmar_0949	5.38e-29	115.0	COG1763@1|root,COG1763@2|Bacteria,4PM6G@976|Bacteroidetes,1FK05@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Mo-molybdopterin cofactor biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1875328_2	1123008.KB905694_gene1703	2.08e-70	229.0	COG0137@1|root,COG0137@2|Bacteria,4NE3R@976|Bacteroidetes,2FMRA@200643|Bacteroidia,22X17@171551|Porphyromonadaceae	976|Bacteroidetes	E	argininosuccinate synthase	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_1385945_1	1265505.ATUG01000001_gene3335	1.22e-92	283.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,42MS9@68525|delta/epsilon subdivisions,2WJMS@28221|Deltaproteobacteria,2MI3S@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_741082_1	1304865.JAGF01000001_gene1911	4.39e-61	208.0	COG1404@1|root,COG1404@2|Bacteria,2GNIX@201174|Actinobacteria,4F2BU@85016|Cellulomonadaceae	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_164590_2	519989.ECTPHS_09223	2.53e-34	118.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Cold shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_751583_1	243233.MCA2487	1.67e-65	213.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RMVW@1236|Gammaproteobacteria,1XE5W@135618|Methylococcales	135618|Methylococcales	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_1630479_1	1033802.SSPSH_000425	7.18e-86	290.0	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,1RMMF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	protein conserved in bacteria	ytfN	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0097347	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
k59_1630479_2	754476.Q7A_1168	4.45e-56	189.0	COG0746@1|root,COG1763@1|root,COG0746@2|Bacteria,COG1763@2|Bacteria,1RH3M@1224|Proteobacteria,1RN20@1236|Gammaproteobacteria,462JK@72273|Thiotrichales	72273|Thiotrichales	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	MobB,NTP_transf_3
k59_1114771_2	1218084.BBJK01000149_gene7524	7.79e-37	136.0	COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,2WBWX@28216|Betaproteobacteria,1K6U7@119060|Burkholderiaceae	28216|Betaproteobacteria	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C
k59_1289546_1	1121019.AUMN01000042_gene2	2.08e-79	246.0	COG3293@1|root,COG3464@1|root,COG3293@2|Bacteria,COG3464@2|Bacteria,2GJK7@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_692407_1	593907.Celgi_2508	1e-81	259.0	COG1249@1|root,COG1249@2|Bacteria,2GMP7@201174|Actinobacteria,4F12W@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	lpdA	GO:0000166,GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016651,GO:0016655,GO:0036094,GO:0043167,GO:0043168,GO:0044419,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051704,GO:0055114,GO:0070401,GO:0097159,GO:1901265,GO:1901363	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_340634_1	105559.Nwat_0437	4.69e-71	226.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1WVY5@135613|Chromatiales	135613|Chromatiales	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_340634_2	533240.CRC_01698	9.5e-51	167.0	COG4122@1|root,COG4122@2|Bacteria,1G2Y6@1117|Cyanobacteria,1HJ3E@1161|Nostocales	1117|Cyanobacteria	S	PFAM O-methyltransferase	-	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
k59_1114783_1	396588.Tgr7_2330	3.37e-104	335.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1289555_1	1171373.PACID_06390	8.22e-67	209.0	COG1514@1|root,COG1514@2|Bacteria,2IKMG@201174|Actinobacteria	201174|Actinobacteria	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
k59_1803342_1	388739.RSK20926_10209	7.83e-58	184.0	COG5528@1|root,COG5528@2|Bacteria,1RDUE@1224|Proteobacteria,2U7HT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2269
k59_1630515_1	384765.SIAM614_07833	6.6e-08	54.3	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2TRW2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_1630515_2	272630.MexAM1_META1p2289	8.41e-24	101.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2TUSP@28211|Alphaproteobacteria,1JR01@119045|Methylobacteriaceae	28211|Alphaproteobacteria	D	PFAM peptidase	filA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1221159_1	1249627.D779_3250	2.78e-47	164.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1WX6G@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_1041256_1	987059.RBXJA2T_12827	9.76e-10	64.7	COG3829@1|root,COG5001@1|root,COG3829@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VMZD@28216|Betaproteobacteria,1KK64@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS,PAS_3
k59_1114814_1	471853.Bcav_1958	2.65e-96	299.0	COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria	201174|Actinobacteria	HI	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_164639_1	765913.ThidrDRAFT_3545	4.21e-22	95.9	COG2091@1|root,COG2091@2|Bacteria,1MZHC@1224|Proteobacteria,1SCGA@1236|Gammaproteobacteria,1WXZ4@135613|Chromatiales	135613|Chromatiales	H	Belongs to the P-Pant transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
k59_164639_2	1123073.KB899242_gene914	8.66e-15	73.6	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,1RSP8@1236|Gammaproteobacteria,1X51U@135614|Xanthomonadales	135614|Xanthomonadales	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
k59_1630520_1	443143.GM18_4033	5.9e-68	231.0	COG1729@1|root,COG1729@2|Bacteria,1MX82@1224|Proteobacteria,42TQ9@68525|delta/epsilon subdivisions,2WR3B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
k59_1041261_1	351016.RAZWK3B_01275	3.79e-88	266.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,2TU33@28211|Alphaproteobacteria,2P2NX@2433|Roseobacter	28211|Alphaproteobacteria	H	COG2998 ABC-type tungstate transport system, permease component	tupA	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
k59_1523638_1	1419583.V466_10805	5.47e-05	49.7	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RXAU@1236|Gammaproteobacteria,1YPR7@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	M	NmrA-like family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_1221174_2	857293.CAAU_1353	1.99e-21	95.9	COG1451@1|root,COG1451@2|Bacteria,1V6WP@1239|Firmicutes,24JGH@186801|Clostridia,36GX1@31979|Clostridiaceae	186801|Clostridia	S	Metal-dependent hydrolase	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
k59_1114839_1	688270.Celal_3960	1.35e-43	153.0	COG0697@1|root,COG0697@2|Bacteria,4NHQX@976|Bacteroidetes,1HYUD@117743|Flavobacteriia,1F7UK@104264|Cellulophaga	976|Bacteroidetes	EG	EamA-like transporter family	-	-	-	ko:K08978	-	-	-	-	ko00000,ko02000	2.A.7.2	-	-	EamA
k59_1396229_1	1265505.ATUG01000001_gene3150	1.46e-72	231.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,42MTU@68525|delta/epsilon subdivisions,2WKN8@28221|Deltaproteobacteria,2MPNF@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NQR2, RnfD, RnfE family	nqrB	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
k59_1396229_2	1125700.HMPREF9195_00467	1.85e-08	56.2	COG4656@1|root,COG4656@2|Bacteria,2J5TG@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_8,RnfC_N,SLBB
k59_1748707_1	765912.Thimo_1264	1.97e-41	155.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1WVV2@135613|Chromatiales	135613|Chromatiales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_573957_1	46681.XP_001741106.1	1.71e-35	133.0	COG0166@1|root,KOG2446@2759|Eukaryota,3X8BP@554915|Amoebozoa	554915|Amoebozoa	G	Glucose-6-phosphate isomerase	-	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
k59_1523665_1	1379270.AUXF01000003_gene3412	2e-45	160.0	COG2211@1|root,COG2211@2|Bacteria,1ZV78@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
k59_1523665_2	349521.HCH_03632	6.82e-72	231.0	COG0730@1|root,COG0730@2|Bacteria,1QRFH@1224|Proteobacteria,1RRFY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	TauE
k59_751665_1	476272.RUMHYD_00878	2.58e-26	102.0	COG1251@1|root,COG1251@2|Bacteria,1V9BG@1239|Firmicutes,24R92@186801|Clostridia	186801|Clostridia	C	BFD-like [2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_BFD
k59_1572401_1	1317124.DW2_18928	2.6e-136	399.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,2TVA2@28211|Alphaproteobacteria,2XP99@285107|Thioclava	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1041298_1	880072.Desac_0311	1.68e-114	360.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Pyr_redox_2
k59_1396234_1	590998.Celf_2853	2.1e-125	366.0	COG0005@1|root,COG0005@2|Bacteria,2GKEI@201174|Actinobacteria,4F0RK@85016|Cellulomonadaceae	201174|Actinobacteria	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	GO:0003674,GO:0003824,GO:0004731,GO:0006139,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009120,GO:0009164,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046121,GO:0046122,GO:0046124,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
k59_1523669_1	1121937.AUHJ01000017_gene3009	3.57e-54	191.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVS@1236|Gammaproteobacteria,46674@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA
k59_633052_1	1265313.HRUBRA_02017	1.1e-104	317.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,1RPTG@1236|Gammaproteobacteria,1J95W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis	deoA	-	2.4.2.4	ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
k59_1221202_1	1286093.C266_17611	4.06e-63	200.0	COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,2VQ39@28216|Betaproteobacteria,1K0AH@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Belongs to the Nudix hydrolase family	nudC_1	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N_2
k59_1396245_1	1335757.SPICUR_03525	2.3e-15	76.6	COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,1WWKI@135613|Chromatiales	135613|Chromatiales	G	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane	lapB	-	-	ko:K19804	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_7
k59_752868_1	717774.Marme_2228	9.53e-85	256.0	2C5PK@1|root,30DRP@2|Bacteria,1REEW@1224|Proteobacteria,1S8KA@1236|Gammaproteobacteria,1XPBE@135619|Oceanospirillales	135619|Oceanospirillales	S	MTH538 TIR-like domain (DUF1863)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1863
k59_1804294_1	1121921.KB898707_gene1286	2.01e-22	101.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,1RNRZ@1236|Gammaproteobacteria,2PMJ2@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	KL	RNA polymerase recycling family C-terminal	rapA	GO:0000166,GO:0001000,GO:0003674,GO:0003676,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03580	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Helicase_C,RapA_C,SNF2_N
k59_1525114_1	593907.Celgi_2530	4.09e-127	371.0	COG0180@1|root,COG0180@2|Bacteria,2GJ9A@201174|Actinobacteria,4F0WM@85016|Cellulomonadaceae	201174|Actinobacteria	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_1157384_1	446466.Cfla_2034	3.07e-45	155.0	COG3177@1|root,COG3177@2|Bacteria,2IAAQ@201174|Actinobacteria	201174|Actinobacteria	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
k59_1631835_1	1282876.BAOK01000001_gene1198	9.43e-53	178.0	COG1721@1|root,COG1721@2|Bacteria,1MWPG@1224|Proteobacteria,2TTDX@28211|Alphaproteobacteria,4BQ8T@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function DUF58	MA20_44650	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_693585_1	631362.Thi970DRAFT_01174	1.44e-42	152.0	COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,1RPY4@1236|Gammaproteobacteria,1WVV1@135613|Chromatiales	135613|Chromatiales	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
k59_515927_1	1304885.AUEY01000024_gene2719	1.05e-65	209.0	COG0543@1|root,COG0543@2|Bacteria,1NTWI@1224|Proteobacteria,42M66@68525|delta/epsilon subdivisions,2WJJ2@28221|Deltaproteobacteria,2MI36@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	nfnB	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
k59_1042775_1	452637.Oter_2422	8.87e-51	167.0	COG1595@1|root,COG1595@2|Bacteria,46VAN@74201|Verrucomicrobia	74201|Verrucomicrobia	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
k59_1222381_1	1298858.AUEL01000022_gene5666	1.03e-72	239.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2TS9R@28211|Alphaproteobacteria,43H25@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	glcB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_224017_1	765912.Thimo_1160	5.09e-98	305.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1WXBH@135613|Chromatiales	135613|Chromatiales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_801988_1	526222.Desal_3047	4.5e-72	242.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MG2T@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_693600_1	768671.ThimaDRAFT_1713	4.1e-93	281.0	COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,1RQ6Z@1236|Gammaproteobacteria,1WWM0@135613|Chromatiales	135613|Chromatiales	P	extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
k59_165931_1	177437.HRM2_33290	5.28e-19	82.8	COG3090@1|root,COG3090@2|Bacteria,1MZNX@1224|Proteobacteria,42TZJ@68525|delta/epsilon subdivisions,2WQB8@28221|Deltaproteobacteria,2MKJH@213118|Desulfobacterales	28221|Deltaproteobacteria	G	PFAM Tripartite ATP-independent periplasmic transporter, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_165931_2	1121456.ATVA01000014_gene793	5.33e-13	72.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,42P2W@68525|delta/epsilon subdivisions,2WKV6@28221|Deltaproteobacteria,2M9KB@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	TIGRFAM TRAP dicarboxylate transporter, DctP subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1692721_1	371731.Rsw2DRAFT_2397	1.33e-47	156.0	COG1321@1|root,COG1321@2|Bacteria,1RH2Z@1224|Proteobacteria,2UA17@28211|Alphaproteobacteria,1FCS2@1060|Rhodobacter	28211|Alphaproteobacteria	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	ko:K11924	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress
k59_1749707_1	367299.JOEE01000001_gene2161	1e-110	348.0	COG0085@1|root,COG0085@2|Bacteria,2GJ81@201174|Actinobacteria,4FF63@85021|Intrasporangiaceae	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1631877_1	1163617.SCD_n01884	1.49e-103	312.0	COG1148@1|root,COG1148@2|Bacteria,1Q0ZF@1224|Proteobacteria,2VUBQ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Glucose inhibited division protein A	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388,ko:K16885	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored
k59_341746_1	697282.Mettu_3978	6.98e-125	381.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,1RP5H@1236|Gammaproteobacteria,1XE4N@135618|Methylococcales	135618|Methylococcales	P	PFAM Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
k59_341746_2	1123354.AUDR01000012_gene1670	2.51e-85	263.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI6Q@28216|Betaproteobacteria,1KRHX@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
k59_802014_1	1278309.KB907104_gene942	8.5e-86	264.0	COG0679@1|root,COG0679@2|Bacteria,1P2SH@1224|Proteobacteria,1RQGC@1236|Gammaproteobacteria,1XHST@135619|Oceanospirillales	135619|Oceanospirillales	S	auxin efflux carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
k59_515960_1	644282.Deba_2839	2.39e-20	90.9	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	-	-	1.12.1.3,1.6.5.3	ko:K00124,ko:K00335,ko:K18331	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_515960_2	439235.Dalk_5090	5.67e-36	135.0	COG1018@1|root,COG1148@1|root,COG1018@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
k59_1397404_1	314278.NB231_10693	4.21e-71	225.0	COG0697@1|root,COG0697@2|Bacteria,1RJFE@1224|Proteobacteria,1RZF0@1236|Gammaproteobacteria,1WWYW@135613|Chromatiales	135613|Chromatiales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1804346_1	1122134.KB893650_gene1371	7.76e-10	56.6	2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SHAU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1525181_1	765912.Thimo_1708	7.17e-88	266.0	COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,1RPHX@1236|Gammaproteobacteria,1WXIR@135613|Chromatiales	135613|Chromatiales	S	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation	-	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
k59_1631892_1	323261.Noc_0770	2.51e-105	336.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1WVV2@135613|Chromatiales	135613|Chromatiales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_1042835_1	1121940.AUDZ01000005_gene1770	3.28e-56	184.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1XHW3@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_1042835_2	1283300.ATXB01000001_gene698	7.97e-115	355.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1XE9Y@135618|Methylococcales	135618|Methylococcales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_802026_1	1206735.BAGG01000032_gene1510	3.56e-18	85.9	COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4G1F3@85025|Nocardiaceae	201174|Actinobacteria	L	Helix-hairpin-helix motif	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
k59_1457841_1	240016.ABIZ01000001_gene2242	1.56e-86	283.0	COG0653@1|root,COG0653@2|Bacteria,46SJC@74201|Verrucomicrobia,2ITJP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_341763_1	1123229.AUBC01000041_gene3817	2.73e-46	158.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2TQZA@28211|Alphaproteobacteria,3JR7B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Methylenetetrahydrofolate reductase	metF	GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
k59_341763_2	228410.NE1623	4.55e-39	146.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2VHYQ@28216|Betaproteobacteria,372NK@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_1042842_2	345201.MCP_IIV3	8.23e-49	170.0	4QAX7@10239|Viruses,4QXNA@35237|dsDNA viruses  no RNA stage	10239|Viruses	S	Large eukaryotic DNA virus major capsid protein	-	GO:0005575,GO:0019012	-	-	-	-	-	-	-	-	-	-	-
k59_752959_1	871968.DESME_15585	3.64e-11	66.6	COG0745@1|root,COG0745@2|Bacteria,1W37V@1239|Firmicutes,25FYR@186801|Clostridia,267F7@186807|Peptococcaceae	186801|Clostridia	KT	Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K02490	ko02020,ko02024,map02020,map02024	M00485	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
k59_1749732_1	518766.Rmar_2008	7.63e-128	378.0	COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,1FJ1P@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79	ko:K00128,ko:K00135	ko00010,ko00053,ko00071,ko00250,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00620,ko00625,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00620,map00625,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130	M00027,M00135	R00264,R00631,R00710,R00713,R00714,R00904,R01752,R01986,R02401,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1749732_2	196367.JNFG01000009_gene6400	2.43e-14	73.2	COG2207@1|root,COG2207@2|Bacteria,1R5XR@1224|Proteobacteria,2WEM7@28216|Betaproteobacteria,1KHS0@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_341771_1	1449357.JQLK01000001_gene96	1.11e-29	112.0	COG0410@1|root,COG0410@2|Bacteria,1WJM5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	ABC-type branched-chain amino acid transport systems ATPase component	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_341771_2	338969.Rfer_1836	1.34e-20	91.7	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2VH2P@28216|Betaproteobacteria,4A9RF@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
k59_1804361_1	411489.CLOL250_00074	5.65e-07	50.4	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,36ET7@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_1692757_1	347834.RHE_CH02901	5.99e-148	457.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria,4B8M0@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_882215_1	290397.Adeh_3056	7.89e-56	186.0	28IN0@1|root,2Z8NG@2|Bacteria,1NKGF@1224|Proteobacteria,43051@68525|delta/epsilon subdivisions	1224|Proteobacteria	H	Glycosyltransferase family 10 (fucosyltransferase) C-term	-	-	2.4.1.152,2.4.1.65	ko:K20151	-	-	-	-	ko00000,ko01000,ko01003	-	GT10	-	Glyco_transf_10
k59_1233726_1	1192034.CAP_0825	1.01e-64	222.0	COG2133@1|root,COG3055@1|root,COG2133@2|Bacteria,COG3055@2|Bacteria,1NRFC@1224|Proteobacteria,42YAV@68525|delta/epsilon subdivisions,2WTUF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_294385_1	340099.Teth39_1338	1.56e-66	223.0	COG1092@1|root,COG1092@2|Bacteria,1TRAJ@1239|Firmicutes,247TI@186801|Clostridia,42F3J@68295|Thermoanaerobacterales	186801|Clostridia	J	SMART PUA domain containing protein	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,PUA
k59_1585820_1	765910.MARPU_14560	5.68e-81	251.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1WWRK@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
k59_353829_1	1121878.AUGL01000007_gene1090	3.88e-101	313.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,1RMHR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2015 Alkyl sulfatase and related hydrolases	BDS1	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_1057708_1	472759.Nhal_3055	4.82e-83	263.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RNES@1236|Gammaproteobacteria,1X2HE@135613|Chromatiales	135613|Chromatiales	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1527106_1	697282.Mettu_0314	2.74e-64	221.0	COG0744@1|root,COG0768@1|root,COG0744@2|Bacteria,COG0768@2|Bacteria,1NRPB@1224|Proteobacteria,1RNG3@1236|Gammaproteobacteria,1XEBS@135618|Methylococcales	135618|Methylococcales	M	Transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	Transgly
k59_529195_1	177437.HRM2_15160	3.09e-21	97.8	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,2MMPS@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	actB	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_118343_1	1166948.JPZL01000002_gene1600	3.87e-58	192.0	COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,1XHFY@135619|Oceanospirillales	135619|Oceanospirillales	S	Deacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
k59_999022_1	1385517.N800_13905	6.18e-201	586.0	COG1164@1|root,COG1164@2|Bacteria,1MWYN@1224|Proteobacteria,1RS2Q@1236|Gammaproteobacteria,1X3UN@135614|Xanthomonadales	135614|Xanthomonadales	E	Angiotensin-converting enzyme	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
k59_999022_2	1121104.AQXH01000001_gene2079	1.41e-35	134.0	COG3104@1|root,COG3104@2|Bacteria,4NE8R@976|Bacteroidetes,1IP39@117747|Sphingobacteriia	976|Bacteroidetes	E	COG3104 Dipeptide tripeptide permease	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
k59_60337_1	1121887.AUDK01000015_gene869	1.89e-27	110.0	28K60@1|root,2Z9UH@2|Bacteria,4NHE6@976|Bacteroidetes,1IEXU@117743|Flavobacteriia,2NYKK@237|Flavobacterium	976|Bacteroidetes	S	Methane oxygenase PmoA	-	-	-	-	-	-	-	-	-	-	-	-	PmoA
k59_999030_1	768671.ThimaDRAFT_3176	3.37e-32	125.0	COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,1T1YN@1236|Gammaproteobacteria,1X2UA@135613|Chromatiales	135613|Chromatiales	T	Bacterial periplasmic substrate-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg,SBP_bac_3
k59_470498_1	314278.NB231_09978	2.1e-88	273.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WVVT@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1821463_1	471853.Bcav_2050	7.38e-124	357.0	COG0036@1|root,COG0036@2|Bacteria,2GJZ9@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_235888_1	1401065.HMPREF2130_07375	9.07e-34	134.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,3T1EQ@506|Alcaligenaceae	28216|Betaproteobacteria	C	Catalyzes the transfer of electrons from NADH to ubiquinone	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1247_1	335543.Sfum_1801	2.61e-20	91.7	COG0247@1|root,COG0247@2|Bacteria,1R8YC@1224|Proteobacteria,42NJW@68525|delta/epsilon subdivisions,2WIX1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_1247_2	335543.Sfum_1175	3.72e-18	76.3	COG1908@1|root,COG1908@2|Bacteria,1NM99@1224|Proteobacteria,42X5B@68525|delta/epsilon subdivisions,2WTHK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
k59_999036_2	323261.Noc_1573	1.02e-35	129.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1WYRM@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_1116337_1	1349820.M707_01765	5.17e-31	121.0	COG0451@1|root,COG0451@2|Bacteria,2GP01@201174|Actinobacteria,1WA44@1268|Micrococcaceae	201174|Actinobacteria	GM	NAD dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_294415_2	323259.Mhun_2529	7.7e-21	86.7	COG2050@1|root,arCOG00777@2157|Archaea,2Y26I@28890|Euryarchaeota	28890|Euryarchaeota	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_822852_1	713586.KB900536_gene2898	3.73e-29	114.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales	135613|Chromatiales	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
k59_822852_2	768671.ThimaDRAFT_0369	7.42e-79	240.0	COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,1S302@1236|Gammaproteobacteria,1WX78@135613|Chromatiales	135613|Chromatiales	C	Protein of unknown function (DUF3501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
k59_705435_1	991905.SL003B_3568	8.8e-101	299.0	COG2113@1|root,COG2113@2|Bacteria,1MVIG@1224|Proteobacteria,2TRV8@28211|Alphaproteobacteria,4BPXS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K02002	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
k59_118372_1	1150621.SMUL_0789	1.05e-05	47.4	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1R5RS@1224|Proteobacteria,42M3K@68525|delta/epsilon subdivisions,2YN6E@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	PFAM biotin lipoyl attachment domain-containing protein	pycB	-	6.4.1.1	ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_470510_1	748671.LCRIS_00023	9.82e-05	43.9	2BV1G@1|root,32QE7@2|Bacteria,1U8KF@1239|Firmicutes,4IIIE@91061|Bacilli,3FB2X@33958|Lactobacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_235903_1	869210.Marky_1024	3.7e-73	229.0	COG1023@1|root,COG1023@2|Bacteria,1WIJ4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	NAD binding domain of 6-phosphogluconate dehydrogenase	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
k59_411806_1	314287.GB2207_03564	1.08e-54	181.0	COG0824@1|root,COG0824@2|Bacteria,1R6A6@1224|Proteobacteria	1224|Proteobacteria	S	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_353883_1	1123487.KB892836_gene3182	4.66e-83	270.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,2KUCG@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC
k59_1409761_1	756272.Plabr_3038	1.69e-17	84.0	COG0651@1|root,COG0651@2|Bacteria,2IXRM@203682|Planctomycetes	203682|Planctomycetes	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_1468588_1	398579.Spea_3282	1.57e-52	176.0	COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,1RR3K@1236|Gammaproteobacteria,2Q9B0@267890|Shewanellaceae	1236|Gammaproteobacteria	P	PFAM Na H antiporter MnhB subunit-related protein	-	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB
k59_1468588_2	402881.Plav_2970	6.33e-12	63.9	COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,2U7UT@28211|Alphaproteobacteria,1JQ4B@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Domain of unknown function (DUF4040)	-	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040
k59_60377_3	667015.Bacsa_2475	4.34e-15	78.2	COG1652@1|root,COG1652@2|Bacteria	2|Bacteria	S	positive regulation of growth rate	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	LysM,SBP_bac_3
k59_530066_1	1123514.KB905899_gene842	1.73e-57	197.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_530066_2	2340.JV46_22530	3.11e-51	174.0	COG0845@1|root,COG0845@2|Bacteria,1PDUT@1224|Proteobacteria,1RQKD@1236|Gammaproteobacteria,1JBNA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_3,HlyD_D23,OEP
k59_1645588_1	575586.HMPREF0016_01854	2.23e-71	233.0	COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,1RR1C@1236|Gammaproteobacteria,3NIWT@468|Moraxellaceae	1236|Gammaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1762734_1	367299.JOEE01000006_gene811	7.42e-105	315.0	COG2271@1|root,COG2271@2|Bacteria,2I2F7@201174|Actinobacteria,4FFEJ@85021|Intrasporangiaceae	201174|Actinobacteria	G	MFS transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1410568_1	1206735.BAGG01000257_gene6293	0.000133	51.6	COG2304@1|root,COG2304@2|Bacteria,2HR55@201174|Actinobacteria,4FZAD@85025|Nocardiaceae	201174|Actinobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	VWA_CoxE
k59_823494_1	1286093.C266_15911	1.25e-52	182.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2WGFS@28216|Betaproteobacteria,1K2YV@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1527872_2	1150399.AQYK01000002_gene2701	2.61e-13	74.7	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FN3A@85023|Microbacteriaceae	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	bfmM	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_942096_2	1265313.HRUBRA_01492	8.58e-169	478.0	COG1442@1|root,COG1442@2|Bacteria,1R5NA@1224|Proteobacteria,1SJX1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_61496_2	1500894.JQNN01000001_gene1999	1.11e-14	73.2	COG4948@1|root,COG4948@2|Bacteria,1NAKW@1224|Proteobacteria,2VIQ3@28216|Betaproteobacteria,4737U@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Mandelate racemase muconate lactonizing enzyme	gudD	-	4.2.1.40	ko:K01706	ko00053,ko01100,map00053,map01100	-	R02752,R08056	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_764774_1	1209072.ALBT01000007_gene2749	2.05e-28	115.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1FH35@10|Cellvibrio	1236|Gammaproteobacteria	H	MoeA N-terminal region (domain I and II)	moeA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0042802,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	iEcHS_1320.EcHS_A0885	MoCF_biosynth,MoeA_C,MoeA_N
k59_1410584_1	1047013.AQSP01000135_gene1613	1.53e-34	132.0	COG0823@1|root,COG0823@2|Bacteria,2NNZC@2323|unclassified Bacteria	2|Bacteria	U	TolB amino-terminal domain	tolB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019534,GO:0019904,GO:0022857,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901998	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_883387_1	472759.Nhal_2432	1.46e-113	333.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1WW3F@135613|Chromatiales	135613|Chromatiales	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
k59_883387_2	95619.PM1_0217445	3.44e-65	205.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0030091,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_177817_1	1304865.JAGF01000001_gene3743	4.93e-37	137.0	COG0324@1|root,COG0324@2|Bacteria,2GKFT@201174|Actinobacteria,4F0Y4@85016|Cellulomonadaceae	201174|Actinobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
k59_1351890_1	765912.Thimo_0697	5.34e-83	257.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1WXDA@135613|Chromatiales	135613|Chromatiales	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
k59_2334_1	2340.JV46_06670	3.56e-34	128.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1J4NG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	GO:0000027,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0022613,GO:0022618,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032794,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0042273,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_2334_2	94624.Bpet4183	1.38e-56	178.0	COG3293@1|root,COG3293@2|Bacteria,1N0VW@1224|Proteobacteria	1224|Proteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2,DUF4096
k59_177818_1	583355.Caka_2045	3.07e-50	189.0	COG0771@1|root,COG2911@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	murD	-	3.4.21.10,6.3.2.13,6.3.2.9	ko:K01317,ko:K01925,ko:K01928,ko:K01932	ko00300,ko00471,ko00550,ko01100,map00300,map00471,map00550,map01100	-	R02783,R02788	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01002,ko01011,ko04131	-	-	-	DUF1727,Mur_ligase_C,Mur_ligase_M
k59_706217_1	1121378.KB899696_gene2620	4.07e-20	93.2	COG5012@1|root,COG5012@2|Bacteria,1WI7R@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	PFAM MerR family regulatory protein	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR,MerR_1
k59_706217_2	448385.sce4900	1.38e-21	92.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,42MY6@68525|delta/epsilon subdivisions,2WMDC@28221|Deltaproteobacteria,2YU5V@29|Myxococcales	28221|Deltaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_530104_1	266264.Rmet_2389	1.35e-25	99.8	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria,1K8MK@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
k59_530104_3	205922.Pfl01_1579	7.98e-07	51.2	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,1RP3R@1236|Gammaproteobacteria,1YPM2@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	iECDH1ME8569_1439.ECDH1ME8569_2134,iSFV_1184.SFV_2275,iSFxv_1172.SFxv_2517,iUTI89_1310.UTI89_C2477,ic_1306.c2736	Cytochrom_C_asm
k59_177827_1	1158292.JPOE01000002_gene3226	6.42e-127	399.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,1KISW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1527903_2	1206739.BAGJ01000158_gene6330	4.02e-59	188.0	COG0262@1|root,COG0262@2|Bacteria,2IM1S@201174|Actinobacteria,4G19Q@85025|Nocardiaceae	201174|Actinobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	GO:0000166,GO:0003674,GO:0003824,GO:0004146,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0070401,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2763c	DHFR_1
k59_1234582_1	1454004.AW11_03086	3.26e-79	258.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2VIFW@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Pfam Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1175857_1	1307437.J139_14821	1.44e-18	83.6	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,1RN90@1236|Gammaproteobacteria,2Q1N6@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02464,ko:K02654	ko03070,map03070	M00331	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
k59_1175857_2	553217.ENHAE0001_1612	1.07e-28	110.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,1S3NR@1236|Gammaproteobacteria,3NIFP@468|Moraxellaceae	1236|Gammaproteobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_0104	CoaE
k59_1527908_1	13735.ENSPSIP00000020651	2.28e-24	98.2	COG1028@1|root,KOG0725@2759|Eukaryota,38H5G@33154|Opisthokonta,3BK2E@33208|Metazoa,3D0KA@33213|Bilateria,48BIW@7711|Chordata,493XD@7742|Vertebrata,4C8H2@8459|Testudines	33208|Metazoa	Q	3-hydroxybutyrate dehydrogenase, type 2	BDH2	GO:0000166,GO:0002262,GO:0002376,GO:0002520,GO:0003674,GO:0003824,GO:0003858,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006518,GO:0006629,GO:0006631,GO:0006635,GO:0006725,GO:0006778,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009062,GO:0009237,GO:0009888,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016627,GO:0016628,GO:0017144,GO:0019184,GO:0019290,GO:0019395,GO:0019538,GO:0019748,GO:0019752,GO:0020027,GO:0021700,GO:0030097,GO:0030099,GO:0030154,GO:0030218,GO:0030258,GO:0030855,GO:0032501,GO:0032502,GO:0032787,GO:0033013,GO:0034101,GO:0034440,GO:0034641,GO:0034645,GO:0036094,GO:0042168,GO:0042440,GO:0042541,GO:0042592,GO:0043043,GO:0043170,GO:0043249,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046395,GO:0046483,GO:0046950,GO:0046951,GO:0048037,GO:0048468,GO:0048469,GO:0048513,GO:0048534,GO:0048731,GO:0048821,GO:0048856,GO:0048869,GO:0048872,GO:0048878,GO:0050662,GO:0050801,GO:0051186,GO:0051188,GO:0051287,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055114,GO:0060429,GO:0061515,GO:0065007,GO:0065008,GO:0071695,GO:0071704,GO:0072329,GO:0097159,GO:0098771,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901568,GO:1901570,GO:1901575,GO:1901576,GO:1902224	1.1.1.30	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	M00088	R01361	RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
k59_883438_1	446466.Cfla_2076	1.75e-117	343.0	COG2010@1|root,COG2010@2|Bacteria,2GKUB@201174|Actinobacteria,4F0W8@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM cytochrome c class I	qcrC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03889	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrome_CBB3
k59_883438_2	1123065.ATWL01000001_gene133	1.98e-105	317.0	COG0723@1|root,COG0723@2|Bacteria,2GIX6@201174|Actinobacteria	201174|Actinobacteria	C	c reductase	qcrA	-	-	ko:K03890	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Rieske
k59_1586587_1	1379698.RBG1_1C00001G0297	7.34e-09	57.0	COG4881@1|root,COG4881@2|Bacteria	2|Bacteria	-	-	cbcU	-	-	-	-	-	-	-	-	-	-	-	NrfD
k59_1586587_2	1348635.BBJY01000002_gene3426	1.97e-08	55.1	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,1S90Z@1236|Gammaproteobacteria,1XXSJ@135623|Vibrionales	135623|Vibrionales	C	COG2863 Cytochrome c553	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_1762787_1	344747.PM8797T_10474	1.09e-40	145.0	COG0523@1|root,COG0523@2|Bacteria,2IXBH@203682|Planctomycetes	203682|Planctomycetes	S	PFAM cobalamin synthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
k59_471390_2	436229.JOEH01000003_gene1819	2.78e-32	128.0	COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria,2NGG5@228398|Streptacidiphilus	201174|Actinobacteria	H	MoeA N-terminal region (domain I and II)	moeA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0071944,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1,2.7.7.9	ko:K00963,ko:K03750	ko00040,ko00052,ko00500,ko00520,ko00790,ko01100,ko01130,map00040,map00052,map00500,map00520,map00790,map01100,map01130	M00129,M00361,M00362,M00549	R00289,R09735	RC00002,RC03462	ko00000,ko00001,ko00002,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_706246_1	367299.JOEE01000007_gene140	2.98e-50	174.0	COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria,4FEZD@85021|Intrasporangiaceae	201174|Actinobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iNJ661.Rv3436c	GATase_6,SIS
k59_706246_2	1120950.KB892784_gene189	3.22e-49	159.0	COG0736@1|root,COG0736@2|Bacteria,2IQF6@201174|Actinobacteria,4DRCQ@85009|Propionibacteriales	201174|Actinobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
k59_942173_1	1388763.O165_016110	2.19e-77	243.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,1YXE0@136845|Pseudomonas putida group	1236|Gammaproteobacteria	M	Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A)	lpxL	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006082,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008951,GO:0009058,GO:0009245,GO:0009247,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0036103,GO:0036104,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046467,GO:0046493,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.241,2.3.1.242	ko:K02517,ko:K12974	ko00540,ko01100,map00540,map01100	M00060	R05146,R10906	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iEC042_1314.EC042_2597,iSF_1195.SF1061,iS_1188.S1138,iYL1228.KPN_01068	Lip_A_acyltrans
k59_355015_2	1193181.BN10_1130011	9.57e-28	114.0	COG0515@1|root,COG0515@2|Bacteria,2GJ24@201174|Actinobacteria,4FFSZ@85021|Intrasporangiaceae	201174|Actinobacteria	KLT	serine threonine protein kinase	pknG	-	2.7.11.1	ko:K14949	ko05152,map05152	-	-	-	ko00000,ko00001,ko01000,ko01001	-	-	-	Pkinase,PknG_TPR,PknG_rubred
k59_883454_1	40373.F991_03079	1e-47	168.0	COG1404@1|root,COG1404@2|Bacteria,1RC5K@1224|Proteobacteria,1S3I9@1236|Gammaproteobacteria,3NIVH@468|Moraxellaceae	1236|Gammaproteobacteria	M	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_1058679_1	314345.SPV1_05994	6.76e-149	429.0	COG3185@1|root,COG3185@2|Bacteria,1R5AJ@1224|Proteobacteria	1224|Proteobacteria	E	4-Hydroxyphenylpyruvate dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1351940_1	1123399.AQVE01000020_gene1702	2.17e-97	304.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,45ZSE@72273|Thiotrichales	72273|Thiotrichales	C	dihydrolipoamide dehydrogenase	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
k59_896705_2	1163617.SCD_n01357	3.54e-92	281.0	COG5660@1|root,32WII@2|Bacteria,1R3ME@1224|Proteobacteria	1224|Proteobacteria	S	TRAP transporter T-component	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
k59_1420805_1	498211.CJA_1490	2.66e-27	109.0	COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,1RN28@1236|Gammaproteobacteria,1FH51@10|Cellvibrio	1236|Gammaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs	dusA	GO:0002943,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	-	ko:K05539	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_1420805_2	765912.Thimo_2344	1.08e-34	122.0	COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,1S64W@1236|Gammaproteobacteria,1WYAU@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM Thioredoxin	-	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
k59_187720_1	305700.B447_03413	1.94e-32	118.0	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,2VRCS@28216|Betaproteobacteria,2KWV5@206389|Rhodocyclales	206389|Rhodocyclales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
k59_187720_2	573065.Astex_2903	1.31e-05	46.6	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,2TRC9@28211|Alphaproteobacteria,2KFIN@204458|Caulobacterales	204458|Caulobacterales	S	TIGRFAM MazG family protein	-	-	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
k59_74963_1	234267.Acid_4507	6.46e-89	275.0	COG0366@1|root,COG0366@2|Bacteria,3Y2P1@57723|Acidobacteria	57723|Acidobacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
k59_1713149_1	1246.JMEA01000003_gene1062	7.96e-14	72.4	COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,4HFRA@91061|Bacilli,4AXUV@81850|Leuconostocaceae	91061|Bacilli	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08940	DMRL_synthase
k59_1713149_2	588932.JHOF01000018_gene771	1.5e-05	47.4	COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,2UBQA@28211|Alphaproteobacteria,2KGQ3@204458|Caulobacterales	204458|Caulobacterales	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
k59_1713152_1	935557.ATYB01000014_gene4274	1.54e-120	362.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,4B81G@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1420812_1	1123392.AQWL01000006_gene608	2.24e-214	602.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2VHPW@28216|Betaproteobacteria,1KRYZ@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_187729_1	396588.Tgr7_0300	4.05e-59	200.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1WWYZ@135613|Chromatiales	135613|Chromatiales	E	PFAM Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_597948_1	1380350.JIAP01000012_gene471	5.14e-73	232.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria,43HIC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_539584_1	2340.JV46_26670	1.57e-40	140.0	2DNYF@1|root,32ZSU@2|Bacteria,1N8ZB@1224|Proteobacteria,1S5ZH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM HupH hydrogenase expression protein	-	-	-	ko:K03618	-	-	-	-	ko00000	-	-	-	HupH_C
k59_1361130_1	644282.Deba_0688	5.99e-95	288.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	nifS-1	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_1836097_1	95619.PM1_0219330	3.82e-21	94.0	COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	ykoW	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9
k59_1836097_2	2340.JV46_18640	1.75e-42	151.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1J4ZF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009314,GO:0009628,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_657367_1	886293.Sinac_2843	3e-09	66.2	COG1680@1|root,COG2173@1|root,COG1680@2|Bacteria,COG2173@2|Bacteria,2IWSU@203682|Planctomycetes	203682|Planctomycetes	MV	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,Peptidase_M15
k59_1595520_2	1385520.N802_16950	8.44e-18	83.2	COG0596@1|root,COG0596@2|Bacteria,2GNFU@201174|Actinobacteria,4FHK7@85021|Intrasporangiaceae	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_480766_1	102129.Lepto7375DRAFT_3736	1.17e-19	93.6	COG2905@1|root,COG5001@1|root,COG2905@2|Bacteria,COG5001@2|Bacteria,1G0BS@1117|Cyanobacteria,1H9V4@1150|Oscillatoriales	1117|Cyanobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF,PAS_4,PAS_9
k59_1125030_2	452652.KSE_08620	9.11e-15	75.9	COG4325@1|root,COG4325@2|Bacteria,2GWFP@201174|Actinobacteria,2M3E6@2063|Kitasatospora	201174|Actinobacteria	S	Predicted membrane protein (DUF2254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
k59_833219_1	1198232.CYCME_2289	8.76e-69	226.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,45ZTE@72273|Thiotrichales	72273|Thiotrichales	M	Catalyzes cross-linking of the peptidoglycan cell wall at the division septum	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
k59_833219_2	1122603.ATVI01000006_gene112	7.36e-11	63.5	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,1X488@135614|Xanthomonadales	135614|Xanthomonadales	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_716023_1	1332071.L581_3718	3.13e-145	432.0	COG0043@1|root,COG0043@2|Bacteria,1PZMY@1224|Proteobacteria,1S199@1236|Gammaproteobacteria,404PN@613|Serratia	1236|Gammaproteobacteria	H	Catalyzes the reversible decarboxylation of aromatic carboxylic acids	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_716023_2	909663.KI867150_gene35	8.15e-71	221.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,42QXP@68525|delta/epsilon subdivisions,2WP9I@28221|Deltaproteobacteria,2MRKK@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
k59_1307903_1	991905.SL003B_4305	2.11e-43	157.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,4BPK3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_1595534_1	177437.HRM2_16310	2.27e-74	235.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,2MICK@213118|Desulfobacterales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1071426_1	682795.AciX8_4783	3.92e-83	271.0	COG3533@1|root,COG3533@2|Bacteria,3Y7GP@57723|Acidobacteria,2JMSH@204432|Acidobacteriia	204432|Acidobacteriia	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
k59_539613_1	1500890.JQNL01000001_gene3236	1.91e-89	281.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1X3W8@135614|Xanthomonadales	135614|Xanthomonadales	IQ	Activates fatty acids by binding to coenzyme A	rpfB	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_1420838_1	1205753.A989_15492	3.93e-62	206.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1X4IP@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA	rlmD	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_252957_1	1415778.JQMM01000001_gene1869	6.91e-58	187.0	COG3145@1|root,COG3145@2|Bacteria,1RGXU@1224|Proteobacteria,1S6DD@1236|Gammaproteobacteria,1J6SS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	COG3145 Alkylated DNA repair protein	alkB	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2
k59_716036_2	1122933.JNIY01000003_gene606	8.07e-42	141.0	COG1666@1|root,COG1666@2|Bacteria,2IFIU@201174|Actinobacteria,4F14K@85016|Cellulomonadaceae	201174|Actinobacteria	S	Belongs to the UPF0234 family	trpF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
k59_1071433_1	522373.Smlt3187	2.65e-13	74.3	2E7DT@1|root,331WV@2|Bacteria,1N62R@1224|Proteobacteria,1SB2G@1236|Gammaproteobacteria,1XD16@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
k59_1071433_2	1122194.AUHU01000009_gene3260	1.59e-05	47.4	COG1131@1|root,COG1131@2|Bacteria,1R3XF@1224|Proteobacteria,1S0MM@1236|Gammaproteobacteria,466CM@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	ATPases associated with a variety of cellular activities	nodI	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1655648_1	1123393.KB891326_gene126	8.95e-78	254.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,2VHS4@28216|Betaproteobacteria,1KSM8@119069|Hydrogenophilales	119069|Hydrogenophilales	O	HypF finger	-	-	-	-	-	-	-	-	-	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_1771657_1	675635.Psed_4791	1.58e-92	283.0	COG0611@1|root,COG0611@2|Bacteria,2GP6E@201174|Actinobacteria,4DY1U@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	GO:0008150,GO:0040007	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2977c	AIRS,AIRS_C
k59_1771657_2	1283283.ATXA01000002_gene2519	3.6e-14	66.6	COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria,4ET4W@85013|Frankiales	201174|Actinobacteria	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
k59_129076_1	545276.KB898725_gene852	3.72e-125	392.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1WXIK@135613|Chromatiales	135613|Chromatiales	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_252958_1	1713.JOFV01000003_gene1436	2.14e-63	211.0	COG0454@1|root,COG0456@2|Bacteria,2I8J8@201174|Actinobacteria,4F1YB@85016|Cellulomonadaceae	201174|Actinobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_772616_1	1489678.RDMS_11055	3.07e-08	58.9	COG0839@1|root,COG0839@2|Bacteria,1WKIC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Belongs to the complex I subunit 6 family	nuoJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_1595541_1	1265505.ATUG01000002_gene1580	1.99e-78	269.0	COG0449@1|root,COG0449@2|Bacteria	2|Bacteria	M	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	-	-	2.6.1.16,5.3.1.8,5.3.1.9	ko:K00820,ko:K15916	ko00010,ko00030,ko00051,ko00250,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko04931,map00010,map00030,map00051,map00250,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map04931	M00001,M00004,M00114	R00768,R01819,R02739,R02740,R03321	RC00010,RC00163,RC00376,RC00563,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,bact-PGI_C
k59_129078_1	1207063.P24_08986	2.26e-39	136.0	COG3476@1|root,COG3476@2|Bacteria,1MZC1@1224|Proteobacteria,2UBYB@28211|Alphaproteobacteria,2JTMR@204441|Rhodospirillales	204441|Rhodospirillales	T	TspO/MBR family	-	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
k59_833241_1	446466.Cfla_1606	1.24e-109	346.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4F1PG@85016|Cellulomonadaceae	201174|Actinobacteria	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_657403_1	713587.THITH_10370	2.64e-181	513.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_1246961_1	743718.Isova_0826	1.55e-29	121.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GJD0@201174|Actinobacteria,4F3NY@85017|Promicromonosporaceae	201174|Actinobacteria	L	UvrD/REP helicase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,PDDEXK_1,UvrD-helicase,UvrD_C
k59_129082_1	1123277.KB893183_gene33	2.95e-147	425.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07495	-	-	-	-	ko00000	-	-	-	DDE_5,DDE_Tnp_1
k59_252980_1	1049564.TevJSym_bo00160	5.81e-91	278.0	COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,1RYUT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Heme d1 biosynthesis protein NirF	nirF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K19345	-	-	-	-	ko00000	-	-	-	Cytochrom_D1
k59_75054_1	42256.RradSPS_2999	1.27e-05	49.3	COG0071@1|root,COG0071@2|Bacteria,2GVDR@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_75054_2	765913.ThidrDRAFT_0707	9.36e-30	114.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1WX4Z@135613|Chromatiales	135613|Chromatiales	S	AI-2E family transporter	-	-	-	ko:K03548	-	-	-	-	ko00000,ko02000	2.A.86.1	-	-	AI-2E_transport
k59_19382_1	1454010.JEOE01000007_gene2008	2.28e-124	365.0	COG2514@1|root,COG2514@2|Bacteria,2GN1X@201174|Actinobacteria,4F1X8@85016|Cellulomonadaceae	201174|Actinobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
k59_480809_1	765913.ThidrDRAFT_0429	1.29e-52	178.0	28N2T@1|root,2ZB8M@2|Bacteria,1R8TQ@1224|Proteobacteria,1S05G@1236|Gammaproteobacteria,1WXJ7@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_480812_1	556268.OFAG_02111	1.47e-112	332.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2VH5D@28216|Betaproteobacteria,472X9@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_657418_1	314607.KB13_497	5.15e-31	115.0	COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,2VN5I@28216|Betaproteobacteria,1KQ11@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4_21
k59_657418_2	270374.MELB17_15896	9.75e-11	63.2	COG1842@1|root,COG4656@1|root,COG1842@2|Bacteria,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,4655V@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfC	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0055114	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB
k59_19395_1	446469.Sked_22000	7.45e-96	292.0	COG1612@1|root,COG1612@2|Bacteria,2GJQX@201174|Actinobacteria	201174|Actinobacteria	O	cytochrome oxidase assembly	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
k59_1655671_1	1049564.TevJSym_an00640	2.7e-62	201.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,1J4SK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0050896,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
k59_1771678_2	1249627.D779_3564	1.76e-20	83.2	COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,1WZ6K@135613|Chromatiales	135613|Chromatiales	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
k59_1713216_1	883067.HMPREF9237_01458	1.6e-72	240.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2GJHB@201174|Actinobacteria,4D3EG@85005|Actinomycetales	201174|Actinobacteria	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
k59_368576_1	675812.VHA_000002	4.64e-54	184.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,1RMMB@1236|Gammaproteobacteria,1XTBR@135623|Vibrionales	135623|Vibrionales	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
k59_1537159_1	1283300.ATXB01000001_gene2284	5.06e-09	60.5	COG3209@1|root,COG3292@1|root,COG3209@2|Bacteria,COG3292@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	Cu_amine_oxidN1,Tail_P2_I
k59_75078_1	478741.JAFS01000002_gene391	3.99e-78	246.0	COG2204@1|root,COG2204@2|Bacteria,46SFE@74201|Verrucomicrobia,37GCZ@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_480821_1	526225.Gobs_1330	5.41e-41	148.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4EVS8@85013|Frankiales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
k59_304676_1	429009.Adeg_1010	4.91e-05	47.4	COG1496@1|root,COG1496@2|Bacteria,1TS34@1239|Firmicutes,248TD@186801|Clostridia,42FXU@68295|Thermoanaerobacterales	186801|Clostridia	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
k59_304676_2	1283300.ATXB01000001_gene407	9.4e-110	326.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,1XEJR@135618|Methylococcales	135618|Methylococcales	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_1308951_1	1109445.AGSX01000043_gene419	3.03e-62	207.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1Z0PU@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	M	3-Deoxy-D-manno-octulosonic-acid transferase	waaA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	iECNA114_1301.ECNA114_3778,iUMNK88_1353.UMNK88_4417	Glycos_transf_1,Glycos_transf_N
k59_1248011_1	84531.JMTZ01000022_gene4194	1.63e-83	261.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1X4R7@135614|Xanthomonadales	135614|Xanthomonadales	E	Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
k59_658174_1	676032.FN3523_0758	9.78e-43	164.0	COG0769@1|root,COG0769@2|Bacteria,1R52S@1224|Proteobacteria,1RVEK@1236|Gammaproteobacteria,460EQ@72273|Thiotrichales	72273|Thiotrichales	M	Mur ligase middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_833970_1	335543.Sfum_0967	5.49e-81	249.0	COG1215@1|root,COG1215@2|Bacteria,1R4ZM@1224|Proteobacteria,42T5P@68525|delta/epsilon subdivisions,2WPSG@28221|Deltaproteobacteria,2MS1Z@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_76043_1	617140.AJZE01000078_gene1847	6.67e-79	255.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGA@1236|Gammaproteobacteria,1XXNF@135623|Vibrionales	135623|Vibrionales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_20550_1	376686.Fjoh_4624	7.96e-48	180.0	COG1251@1|root,COG1251@2|Bacteria,4NE44@976|Bacteroidetes,1HZ81@117743|Flavobacteriia,2NT9G@237|Flavobacterium	976|Bacteroidetes	C	nitrite reductase NAD(P)H , large subunit	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
k59_1125684_1	926549.KI421517_gene3515	5.21e-59	198.0	COG0189@1|root,COG0189@2|Bacteria,4NF2R@976|Bacteroidetes,47P1C@768503|Cytophagia	976|Bacteroidetes	HJ	RimK-like ATPgrasp N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Dala_Dala_lig_C,RLAN,RimK
k59_76054_1	1380354.JIAN01000005_gene1474	7.32e-105	313.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase	aspC	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_540426_1	349124.Hhal_1747	5.41e-82	256.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1WVXW@135613|Chromatiales	135613|Chromatiales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
k59_897861_1	1123065.ATWL01000008_gene2413	1.98e-20	93.6	COG1040@1|root,COG1040@2|Bacteria,2I9PA@201174|Actinobacteria	201174|Actinobacteria	S	phosphoribosyltransferase	pyrE_1	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
k59_1656406_2	933115.GPDM_08200	5.17e-24	102.0	COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,4HBHX@91061|Bacilli,26H1R@186818|Planococcaceae	91061|Bacilli	E	Pyridoxal-phosphate dependent enzyme	eutB	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1421632_1	95619.PM1_0215085	4.88e-73	230.0	COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,1RNE6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	protein conserved in bacteria	prpF	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016853,GO:0016860,GO:0016863,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0046459,GO:0071704,GO:0072329,GO:1901575	-	ko:K09788	ko00640,map00640	-	R11264	RC03405	ko00000,ko00001,ko01000	-	-	-	PrpF
k59_1483112_1	1096546.WYO_1156	6.12e-83	257.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,2TTZ4@28211|Alphaproteobacteria,1JRMV@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
k59_1013779_1	666685.R2APBS1_3360	1.44e-69	218.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1X4E7@135614|Xanthomonadales	135614|Xanthomonadales	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
k59_1368792_1	743718.Isova_0669	5.88e-116	336.0	COG0094@1|root,COG0094@2|Bacteria,2GJW7@201174|Actinobacteria,4F3GQ@85017|Promicromonosporaceae	201174|Actinobacteria	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_1368792_2	1380354.JIAN01000005_gene1441	5.51e-26	97.8	COG0198@1|root,COG0198@2|Bacteria,2IKP2@201174|Actinobacteria,4F1DR@85016|Cellulomonadaceae	201174|Actinobacteria	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
k59_907231_1	349521.HCH_06423	5e-93	294.0	COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,1RMNH@1236|Gammaproteobacteria,1XHAB@135619|Oceanospirillales	135619|Oceanospirillales	K	accessory protein	-	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
k59_1428403_1	1203605.HMPREF1531_01705	9.01e-96	308.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1149@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1149@2|Bacteria,2I995@201174|Actinobacteria,4DVUV@85009|Propionibacteriales	201174|Actinobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1318409_1	1340493.JNIF01000004_gene1116	3.27e-20	85.9	2E7HP@1|root,33206@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1475)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1475
k59_907237_1	1120983.KB894574_gene1071	2.4e-71	218.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,2U77Q@28211|Alphaproteobacteria,1JP4E@119043|Rhodobiaceae	28211|Alphaproteobacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.1,3.5.4.3,3.5.4.33	ko:K01485,ko:K01487,ko:K11991	ko00230,ko00240,ko00330,ko01100,map00230,map00240,map00330,map01100	-	R00974,R01411,R01676,R02922,R10223	RC00074,RC00204,RC00477,RC00514,RC00809	ko00000,ko00001,ko01000,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
k59_1256820_1	880072.Desac_0917	1.91e-77	248.0	COG1148@1|root,COG1148@2|Bacteria,1QUMN@1224|Proteobacteria,43BMA@68525|delta/epsilon subdivisions,2X6ZG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	hdrA	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
k59_1602903_1	879212.DespoDRAFT_01989	4.16e-64	217.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NHP@68525|delta/epsilon subdivisions,2X6U1@28221|Deltaproteobacteria,2MHMI@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM ribonuclease II	-	-	3.1.13.1	ko:K01147,ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_1846577_2	398512.JQKC01000005_gene5470	9.98e-74	230.0	COG0860@1|root,COG0860@2|Bacteria,1TQ50@1239|Firmicutes,249IF@186801|Clostridia,3WIH3@541000|Ruminococcaceae	186801|Clostridia	MT	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,SH3_3,SPOR
k59_85384_1	566466.NOR53_3413	1.3e-40	152.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
k59_312262_1	1454004.AW11_02552	1.31e-62	200.0	COG1192@1|root,COG1192@2|Bacteria,1MVEZ@1224|Proteobacteria,2VK7W@28216|Betaproteobacteria	28216|Betaproteobacteria	D	Cobyrinic acid ac-diamide synthase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_778882_2	58344.JOEL01000001_gene389	2.52e-06	50.1	COG0664@1|root,COG0664@2|Bacteria,2GQ2Y@201174|Actinobacteria	201174|Actinobacteria	K	Crp-like helix-turn-helix domain	-	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_1013799_1	1122134.KB893651_gene2275	1.47e-23	104.0	COG3249@1|root,COG3249@2|Bacteria,1N0PD@1224|Proteobacteria,1S9C4@1236|Gammaproteobacteria,1XKGD@135619|Oceanospirillales	135619|Oceanospirillales	S	protein conserved in bacteria	-	-	-	ko:K09938	-	-	-	-	ko00000	-	-	-	DUF2066
k59_31318_1	1131553.JIBI01000051_gene966	1.41e-111	333.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,2WBWD@28216|Betaproteobacteria,373ZW@32003|Nitrosomonadales	28216|Betaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrB	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
k59_1780180_1	765913.ThidrDRAFT_4084	1.03e-87	275.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,1RNQI@1236|Gammaproteobacteria,1WW64@135613|Chromatiales	135613|Chromatiales	M	Belongs to the mannose-6-phosphate isomerase type 2 family	-	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_724167_1	526225.Gobs_1672	7.64e-07	50.1	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4ERQZ@85013|Frankiales	201174|Actinobacteria	G	pyruvate phosphate dikinase, PEP	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1492500_1	1291050.JAGE01000002_gene3468	7.46e-86	276.0	COG1236@1|root,COG1236@2|Bacteria,1TQBH@1239|Firmicutes,248QR@186801|Clostridia,3WHA0@541000|Ruminococcaceae	186801|Clostridia	J	Metallo-beta-lactamase domain protein	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
k59_1194312_1	1049564.TevJSym_ap00450	0.000228	48.9	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1J4HS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_1014566_1	321332.CYB_0748	2.61e-44	152.0	COG0637@1|root,COG0637@2|Bacteria,1G2T2@1117|Cyanobacteria,1GZ2D@1129|Synechococcus	1117|Cyanobacteria	S	HAD-superfamily hydrolase subfamily IA, variant 3	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_1014566_2	323261.Noc_0881	9.75e-15	73.6	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNXA@1236|Gammaproteobacteria,1WWTQ@135613|Chromatiales	135613|Chromatiales	E	PFAM aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_1603776_1	644282.Deba_0734	4.57e-131	384.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,42M15@68525|delta/epsilon subdivisions,2WIQN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_547679_1	1545915.JROG01000007_gene3100	1.25e-12	69.7	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2TRU4@28211|Alphaproteobacteria,2K02W@204457|Sphingomonadales	204457|Sphingomonadales	O	peptidase M13	-	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
k59_489183_1	1121033.AUCF01000046_gene538	5.98e-60	202.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TS80@28211|Alphaproteobacteria,2JR07@204441|Rhodospirillales	204441|Rhodospirillales	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_1132790_2	1121106.JQKB01000027_gene1872	7.42e-41	149.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,2JPVD@204441|Rhodospirillales	204441|Rhodospirillales	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	-	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8
k59_1369728_1	243233.MCA2543	4.89e-115	365.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1XE1A@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
k59_1257934_1	754477.Q7C_2215	1.91e-55	184.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,45ZV4@72273|Thiotrichales	72273|Thiotrichales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
k59_1257934_2	1049564.TevJSym_ag00070	1.16e-27	107.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1J7JW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Cytochrome C1 family	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
k59_1319835_1	1211114.ALIP01000011_gene1583	1.11e-29	118.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1X4P8@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_1319835_2	1177181.T9A_02095	2.5e-22	95.5	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1XHU3@135619|Oceanospirillales	135619|Oceanospirillales	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_1083846_1	768671.ThimaDRAFT_1873	1.47e-93	281.0	COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,1RQKK@1236|Gammaproteobacteria,1WWDF@135613|Chromatiales	135613|Chromatiales	S	ATPase (AAA superfamily)	-	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
k59_265210_2	1035308.AQYY01000001_gene3360	3.78e-47	162.0	COG1108@1|root,COG1108@2|Bacteria,1TR79@1239|Firmicutes,24875@186801|Clostridia,261UN@186807|Peptococcaceae	186801|Clostridia	P	ABC-type Mn2 Zn2 transport	adcB	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
k59_606411_2	1499967.BAYZ01000009_gene5287	2.03e-23	94.0	COG0636@1|root,COG0636@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110,ko:K02124	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157,M00159	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1,3.A.2.2,3.A.2.3	-	-	ATP-synt_C
k59_665789_1	595460.RRSWK_05970	2.13e-97	298.0	COG1502@1|root,COG1502@2|Bacteria,2IYFI@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
k59_1847995_2	384765.SIAM614_02581	3.97e-10	61.6	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1257939_1	640081.Dsui_2182	2.55e-64	211.0	COG0477@1|root,COG2814@2|Bacteria,1QUTR@1224|Proteobacteria,2VHHN@28216|Betaproteobacteria,2KZXW@206389|Rhodocyclales	206389|Rhodocyclales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1429397_1	521674.Plim_1538	2.24e-59	200.0	COG0263@1|root,COG0263@2|Bacteria,2IXTU@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
k59_1429397_2	998088.B565_3287	3.75e-09	58.5	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1Y3E1@135624|Aeromonadales	135624|Aeromonadales	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1492539_1	935839.JAGJ01000003_gene1521	3.64e-14	72.4	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2GIWJ@201174|Actinobacteria,4F3A1@85017|Promicromonosporaceae	201174|Actinobacteria	H	3,4-dihydroxy-2-butanone 4-phosphate synthase	ribA	-	3.5.4.25,4.1.99.12	ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2,Lum_binding
k59_1194346_2	316067.Geob_1416	0.000627	45.8	COG1835@1|root,COG1835@2|Bacteria,1REU1@1224|Proteobacteria,431CG@68525|delta/epsilon subdivisions,2WWN0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_265219_1	1385518.N798_17465	1.37e-40	148.0	COG0626@1|root,COG0626@2|Bacteria,2GMD8@201174|Actinobacteria,4FG2D@85021|Intrasporangiaceae	201174|Actinobacteria	E	cystathionine gamma-synthase	metB	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1848000_2	1121405.dsmv_3080	5e-14	69.7	COG5403@1|root,COG5403@2|Bacteria,1PY2R@1224|Proteobacteria,42Y17@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	PFAM Bacterial protein of	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
k59_137552_1	1121920.AUAU01000008_gene1564	3.7e-23	102.0	COG0476@1|root,COG0476@2|Bacteria,3Y2HZ@57723|Acidobacteria	57723|Acidobacteria	H	MoeZ MoeB domain	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
k59_665794_1	1003200.AXXA_14648	1.94e-33	131.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VH4J@28216|Betaproteobacteria,3T233@506|Alcaligenaceae	28216|Betaproteobacteria	S	ATPase components of ABC transporters with duplicated ATPase domains	uup	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_1664295_1	1500306.JQLA01000032_gene3730	8.44e-97	291.0	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,2TUZX@28211|Alphaproteobacteria,4BAR3@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
k59_380374_1	1267005.KB911258_gene415	4.28e-19	84.0	28I3D@1|root,2Z876@2|Bacteria,1P0DR@1224|Proteobacteria,2TTG2@28211|Alphaproteobacteria,3N757@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	PilZ domain	MA20_31715	-	-	-	-	-	-	-	-	-	-	-	PilZ
k59_380374_2	1410620.SHLA_45c000280	8.33e-11	64.3	COG3672@1|root,COG3672@2|Bacteria	2|Bacteria	O	Periplasmic Protein	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,Peptidase_C93,Transglut_core
k59_1545661_1	765420.OSCT_0473	7.41e-24	101.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2G5QP@200795|Chloroflexi,3770F@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_1545661_2	211586.SO_0745	1.72e-12	67.4	2E9KN@1|root,333TE@2|Bacteria,1NCTP@1224|Proteobacteria,1SFMQ@1236|Gammaproteobacteria,2QCVA@267890|Shewanellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_265226_1	582744.Msip34_0660	3.45e-136	407.0	COG0260@1|root,COG0260@2|Bacteria,1MXP6@1224|Proteobacteria,2VJ0K@28216|Betaproteobacteria,2KKKC@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Belongs to the peptidase M17 family	-	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17
k59_1545662_1	589865.DaAHT2_2533	3.29e-06	48.5	COG1075@1|root,COG1075@2|Bacteria,1N2W0@1224|Proteobacteria	1224|Proteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4,PGAP1
k59_1545662_2	396588.Tgr7_2239	1.18e-44	151.0	COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,1S20Q@1236|Gammaproteobacteria,1WY8G@135613|Chromatiales	135613|Chromatiales	L	pfam nudix	-	-	3.6.1.67	ko:K08310	ko00790,map00790	M00126	R04638	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
k59_606425_1	926556.Echvi_0366	4.42e-48	166.0	COG4874@1|root,COG4874@2|Bacteria,4NFG3@976|Bacteroidetes,47KEY@768503|Cytophagia	976|Bacteroidetes	S	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
k59_1492558_1	933262.AXAM01000010_gene1405	1.75e-72	229.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2WJ59@28221|Deltaproteobacteria,2MHP1@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_967610_2	795666.MW7_3014	3.38e-05	46.2	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2VHXG@28216|Betaproteobacteria,1K2IB@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_380388_1	1168034.FH5T_18985	5.56e-95	298.0	COG5009@1|root,COG5009@2|Bacteria,4NECJ@976|Bacteroidetes,2FNBG@200643|Bacteroidia	976|Bacteroidetes	M	transglycosylase	ponA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
k59_1319867_1	314262.MED193_19114	2.48e-31	124.0	COG0419@1|root,COG0419@2|Bacteria,1MXMI@1224|Proteobacteria,2TU9I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	ATPase involved in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23,AAA_27
k59_1319867_2	1267005.KB911256_gene1990	2.52e-19	83.2	COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2U5DW@28211|Alphaproteobacteria,3N8U2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_1083869_1	1122604.JONR01000007_gene2924	4.11e-94	295.0	COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,1X57M@135614|Xanthomonadales	135614|Xanthomonadales	E	Sodium alanine symporter	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_779750_2	765420.OSCT_3186	3.39e-78	253.0	COG4995@1|root,COG4995@2|Bacteria,2G8YF@200795|Chloroflexi,377C0@32061|Chloroflexia	32061|Chloroflexia	P	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,SIR2_2
k59_86830_1	526226.Gbro_2784	1.42e-119	348.0	COG2326@1|root,COG2326@2|Bacteria,2GKRN@201174|Actinobacteria,4GBHJ@85026|Gordoniaceae	201174|Actinobacteria	S	Polyphosphate kinase 2 (PPK2)	ppk2	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005525,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006183,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030808,GO:0031323,GO:0031326,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046777,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051704,GO:0055086,GO:0062012,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0080090,GO:0090407,GO:0097159,GO:0097367,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
k59_1721759_1	497964.CfE428DRAFT_4579	6.41e-104	318.0	COG0018@1|root,COG0018@2|Bacteria,46SH6@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Arginyl tRNA synthetase N terminal dom	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_841620_1	367299.JOEE01000004_gene1259	4.56e-05	45.1	COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,2GKB8@201174|Actinobacteria,4FFXJ@85021|Intrasporangiaceae	201174|Actinobacteria	P	TrkA-N domain	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
k59_841620_2	367299.JOEE01000004_gene1260	3.77e-117	342.0	COG1607@1|root,COG1607@2|Bacteria,2GK6X@201174|Actinobacteria,4FG67@85021|Intrasporangiaceae	201174|Actinobacteria	I	Thioesterase superfamily	-	-	3.1.2.23	ko:K01075,ko:K10806	ko00130,ko00362,ko01040,ko01100,ko01110,ko01120,map00130,map00362,map01040,map01100,map01110,map01120	-	R01301	RC00004,RC00174	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT
k59_1319877_1	926569.ANT_10860	8.7e-91	298.0	COG0086@1|root,COG0086@2|Bacteria,2G632@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1664323_1	28444.JODQ01000013_gene2933	1.62e-72	224.0	COG4430@1|root,COG4430@2|Bacteria,2II0D@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
k59_1319886_1	1043493.BBLU01000006_gene2171	6.08e-19	86.3	COG1073@1|root,COG1073@2|Bacteria,2IHUE@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_5
k59_86849_1	338963.Pcar_1719	4e-89	275.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,43DRR@68525|delta/epsilon subdivisions,2X70U@28221|Deltaproteobacteria,43U12@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metY-2	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1429437_1	765910.MARPU_07770	1.1e-70	231.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1RSFG@1236|Gammaproteobacteria,1WW9R@135613|Chromatiales	135613|Chromatiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_1492587_1	305900.GV64_08955	1.02e-39	143.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,1XHVU@135619|Oceanospirillales	135619|Oceanospirillales	P	) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_86853_1	240015.ACP_2235	5.96e-85	272.0	COG3957@1|root,COG3957@2|Bacteria,3Y3XU@57723|Acidobacteria,2JKSB@204432|Acidobacteriia	204432|Acidobacteriia	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
k59_547748_1	1304865.JAGF01000001_gene3550	2.18e-184	522.0	COG0133@1|root,COG0133@2|Bacteria,2GM7Z@201174|Actinobacteria,4F0I5@85016|Cellulomonadaceae	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PALP
k59_1083893_1	471853.Bcav_2900	6.56e-118	349.0	COG3173@1|root,COG3173@2|Bacteria,2I8R6@201174|Actinobacteria	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	mphA	-	-	-	-	-	-	-	-	-	-	-	APH
k59_1848054_1	1038867.AXAY01000002_gene3455	3.33e-39	136.0	COG1416@1|root,COG1416@2|Bacteria,1MZM7@1224|Proteobacteria,2UCT2@28211|Alphaproteobacteria,3JXSD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	DsrE/DsrF-like family	-	-	-	ko:K09004	-	-	-	-	ko00000	-	-	-	DrsE
k59_99088_1	1049564.TevJSym_ad00550	1.52e-117	345.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1J5C7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_49kDa
k59_99088_2	768671.ThimaDRAFT_1750	1.85e-85	255.0	COG0852@1|root,COG0852@2|Bacteria,1RB4M@1224|Proteobacteria,1S3KE@1236|Gammaproteobacteria,1WY1J@135613|Chromatiales	135613|Chromatiales	C	NADH ubiquinone oxidoreductase	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_613493_1	177437.HRM2_10730	2.11e-05	45.8	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MI0N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_613493_2	177437.HRM2_10740	2.02e-26	101.0	COG1426@1|root,COG1917@1|root,COG1426@2|Bacteria,COG1917@2|Bacteria,1QWMR@1224|Proteobacteria,43BSQ@68525|delta/epsilon subdivisions,2X73G@28221|Deltaproteobacteria,2MPJK@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_31
k59_1552342_1	1089551.KE386572_gene1826	3.75e-33	132.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2TTMN@28211|Alphaproteobacteria,4BRUU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_8
k59_785672_2	631362.Thi970DRAFT_04709	1.09e-77	242.0	COG0826@1|root,COG0826@2|Bacteria,1MWFW@1224|Proteobacteria,1RMWM@1236|Gammaproteobacteria,1WVVX@135613|Chromatiales	135613|Chromatiales	O	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_U32
k59_1728883_1	1049564.TevJSym_ac01740	3.29e-94	305.0	28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria,1S1M3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
k59_1376405_1	460265.Mnod_1068	4.31e-73	226.0	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2TT1U@28211|Alphaproteobacteria,1JSJM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	GO:0003674,GO:0003824,GO:0004733,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
k59_1860556_1	768671.ThimaDRAFT_3757	4.16e-68	224.0	COG0421@1|root,COG0421@2|Bacteria,1QZ2Z@1224|Proteobacteria	1224|Proteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_785683_1	864069.MicloDRAFT_00027590	6.36e-21	99.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16,TPR_8,TolB_N
k59_1139100_1	1283287.KB822584_gene1336	5.08e-107	323.0	COG1171@1|root,COG1171@2|Bacteria,2GJAG@201174|Actinobacteria,4DN8T@85009|Propionibacteriales	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
k59_1332289_1	1380390.JIAT01000010_gene3603	1.04e-28	118.0	COG0354@1|root,COG0354@2|Bacteria,2GKP0@201174|Actinobacteria,4CQCX@84995|Rubrobacteria	84995|Rubrobacteria	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
k59_1786348_1	367299.JOEE01000011_gene3149	1.18e-48	159.0	2EID2@1|root,33C4E@2|Bacteria,2IH8P@201174|Actinobacteria,4FGUT@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF4245)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4245
k59_1786348_2	367299.JOEE01000011_gene3151	8.93e-32	112.0	COG1722@1|root,COG1722@2|Bacteria,2GR0U@201174|Actinobacteria,4FHFV@85021|Intrasporangiaceae	201174|Actinobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
k59_1786348_3	1385518.N798_06230	5.52e-43	153.0	COG1570@1|root,COG1570@2|Bacteria,2GJAS@201174|Actinobacteria,4FESU@85021|Intrasporangiaceae	201174|Actinobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_392622_2	1500893.JQNB01000001_gene773	1.2e-28	107.0	COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,1S61I@1236|Gammaproteobacteria,1X6FE@135614|Xanthomonadales	135614|Xanthomonadales	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
k59_392622_3	768066.HELO_3775	3.14e-11	60.8	COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,1SCC7@1236|Gammaproteobacteria,1XM7C@135619|Oceanospirillales	135619|Oceanospirillales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_392622_4	1158146.KB907121_gene1231	2.61e-08	56.2	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,1SD9K@1236|Gammaproteobacteria,1WZ88@135613|Chromatiales	135613|Chromatiales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	-	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_785687_1	290512.Paes_0629	1.4e-213	597.0	COG3344@1|root,COG3344@2|Bacteria	2|Bacteria	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_275324_2	136273.GY22_03525	2.36e-28	117.0	COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria,1W7PK@1268|Micrococcaceae	201174|Actinobacteria	M	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2158c	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1786352_1	439235.Dalk_2524	3.94e-53	171.0	COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,42R9D@68525|delta/epsilon subdivisions,2WN5Q@28221|Deltaproteobacteria,2MJN0@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00124,ko:K07307	ko00630,ko00680,ko00920,ko01100,ko01120,ko01200,map00630,map00680,map00920,map01100,map01120,map01200	-	R00519,R09501	RC02555,RC02796	ko00000,ko00001,ko02000	5.A.3.3	-	-	Fer4_11,Fer4_4,Fer4_7
k59_1786352_2	555779.Dthio_PD1395	1.67e-16	80.1	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42M9D@68525|delta/epsilon subdivisions,2WJ43@28221|Deltaproteobacteria,2M8UY@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1728901_1	450380.JPSY01000001_gene843	1.96e-126	377.0	COG2865@1|root,COG2865@2|Bacteria,2I3IG@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
k59_1728901_2	234267.Acid_2544	2.09e-52	181.0	COG2267@1|root,COG2267@2|Bacteria,3Y973@57723|Acidobacteria	57723|Acidobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_731369_1	203122.Sde_1930	1.85e-71	237.0	COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria,464X2@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cusB	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	CusF_Ec,HlyD_D23,HlyD_D4
k59_731369_2	305900.GV64_09500	8.43e-43	163.0	COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,1RPGN@1236|Gammaproteobacteria,1XHHM@135619|Oceanospirillales	135619|Oceanospirillales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1139113_1	933262.AXAM01000106_gene2631	1.2e-100	302.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,42R11@68525|delta/epsilon subdivisions,2WMWN@28221|Deltaproteobacteria,2MMZB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_731372_1	1216932.CM240_1446	6.99e-09	62.4	COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes,247KB@186801|Clostridia,36E7M@31979|Clostridiaceae	186801|Clostridia	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
k59_1500667_1	754476.Q7A_2839	2.87e-77	247.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,4601B@72273|Thiotrichales	72273|Thiotrichales	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1610539_2	765912.Thimo_1809	1.43e-37	134.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1WXNB@135613|Chromatiales	135613|Chromatiales	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_785695_1	1123392.AQWL01000006_gene709	2.27e-39	142.0	COG2010@1|root,COG3439@1|root,COG2010@2|Bacteria,COG3439@2|Bacteria,1R6Z0@1224|Proteobacteria,2VRTH@28216|Betaproteobacteria,1KSIM@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,DUF302
k59_785695_2	713586.KB900536_gene2263	4.95e-35	126.0	COG3439@1|root,COG3439@2|Bacteria,1N3NF@1224|Proteobacteria,1ST0K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_99184_1	717774.Marme_3869	4.29e-28	114.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,1RS6U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1552391_1	1089544.KB912942_gene1878	3.92e-33	132.0	COG3408@1|root,COG3408@2|Bacteria,2GIUI@201174|Actinobacteria,4DXAD@85010|Pseudonocardiales	201174|Actinobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
k59_1201495_1	467661.RKLH11_3924	7.6e-166	468.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_32,rve,rve_3
k59_1376444_1	1254432.SCE1572_03160	1.97e-97	299.0	COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,42PTC@68525|delta/epsilon subdivisions,2WM3S@28221|Deltaproteobacteria,2YTUU@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
k59_1376444_2	1245475.ANAE01000151_gene4703	2.5e-20	96.7	COG1957@1|root,COG1957@2|Bacteria,2GP6N@201174|Actinobacteria,4EH7B@85012|Streptosporangiales	201174|Actinobacteria	F	Inosine-uridine preferring nucleoside hydrolase	rihA	-	-	ko:K01250,ko:K12700	-	-	-	-	ko00000,ko01000	-	-	-	IU_nuc_hydro
k59_1266270_1	349521.HCH_00108	2.5e-43	157.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1XH7K@135619|Oceanospirillales	135619|Oceanospirillales	C	NADH-quinone oxidoreductase subunit F	-	-	1.12.1.2	ko:K18005	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S
k59_1436594_1	96561.Dole_0706	6.87e-106	315.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2MHTQ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_785700_1	247490.KSU1_C0392	3.35e-101	320.0	COG0466@1|root,COG0466@2|Bacteria,2IYNA@203682|Planctomycetes	203682|Planctomycetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_496286_1	882.DVU_0611	3.36e-92	280.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NTG@68525|delta/epsilon subdivisions,2WKHW@28221|Deltaproteobacteria,2MG5F@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	PFAM ABC transporter related	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_1332353_1	1306174.JODP01000001_gene5104	2.83e-188	551.0	COG0507@1|root,COG0507@2|Bacteria,2GIX1@201174|Actinobacteria	201174|Actinobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	recD	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,UvrD_C_2
k59_921064_1	870187.Thini_1271	2.83e-47	160.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria,4608T@72273|Thiotrichales	72273|Thiotrichales	E	TIGRFAM Serine O-acetyltransferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
k59_1376454_1	670307.HYPDE_23783	2.47e-74	231.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2TUHH@28211|Alphaproteobacteria,3N6PE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
k59_99202_1	292564.Cyagr_2229	9.18e-156	449.0	COG0499@1|root,COG0499@2|Bacteria,1G1MN@1117|Cyanobacteria,22S2X@167375|Cyanobium	1117|Cyanobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_99202_2	1116472.MGMO_124c00080	2.08e-216	604.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,1XEHS@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_921068_1	1123274.KB899413_gene777	1.3e-103	314.0	COG0493@1|root,COG0493@2|Bacteria,2J5FP@203691|Spirochaetes	203691|Spirochaetes	C	glutamate synthase (NADPH), homotetrameric	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2,Pyr_redox_3
k59_1333822_1	543632.JOJL01000050_gene7393	4.78e-30	114.0	2AY0M@1|root,31Q26@2|Bacteria,2IMBI@201174|Actinobacteria,4DGA5@85008|Micromonosporales	201174|Actinobacteria	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N,SHOCT
k59_204037_1	886293.Sinac_7397	6.56e-22	95.1	COG1861@1|root,COG1861@2|Bacteria,2J3F7@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_1021288_1	1411123.JQNH01000001_gene2097	2.24e-21	98.2	COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria	1224|Proteobacteria	P	ABC-type Fe3 transport system, periplasmic component	-	-	-	ko:K02012,ko:K11081	ko02010,map02010	M00190,M00302	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10,3.A.1.11.5	-	-	SBP_bac_6
k59_922569_1	2340.JV46_11310	2.07e-22	95.1	COG1073@1|root,COG1073@2|Bacteria,1R76C@1224|Proteobacteria,1RR34@1236|Gammaproteobacteria,1J69T@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
k59_145463_1	713587.THITH_06735	6.9e-97	300.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXFK@135613|Chromatiales	135613|Chromatiales	GM	nucleoside-diphosphate sugar epimerase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
k59_1093145_1	446471.Xcel_1993	2.81e-27	116.0	2AR9G@1|root,31GJC@2|Bacteria,2I0KT@201174|Actinobacteria,4F4KM@85017|Promicromonosporaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4192)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4192
k59_732290_1	760117.JN27_06470	1.52e-10	66.6	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,2VJCC@28216|Betaproteobacteria,4743M@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_394144_2	479433.Caci_1145	5.79e-08	54.3	COG1610@1|root,COG1610@2|Bacteria,2GQVP@201174|Actinobacteria	201174|Actinobacteria	S	YqeY-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
k59_981651_1	395965.Msil_2051	2.71e-65	209.0	COG1063@1|root,COG1063@2|Bacteria,1MVZC@1224|Proteobacteria,2TRM6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Dehydrogenase	bchC	-	1.1.1.396	ko:K11337	ko00860,ko01110,map00860,map01110	-	R09055	RC01377	ko00000,ko00001,ko01000	-	-	-	ADH_N
k59_1729821_1	765912.Thimo_1241	8.19e-87	268.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales	135613|Chromatiales	P	PFAM TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_1021296_1	572477.Alvin_1248	1.69e-09	57.0	2CARE@1|root,2Z8Q5@2|Bacteria,1R7S8@1224|Proteobacteria,1RRAH@1236|Gammaproteobacteria,1WW2H@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM CRISPR-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Cas6
k59_1021296_2	765912.Thimo_0545	5.55e-56	176.0	COG2920@1|root,COG2920@2|Bacteria,1RISY@1224|Proteobacteria,1S8HB@1236|Gammaproteobacteria,1WYQ6@135613|Chromatiales	135613|Chromatiales	P	Part of a sulfur-relay system	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_981659_1	631362.Thi970DRAFT_04547	1.88e-42	153.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,1WVWN@135613|Chromatiales	135613|Chromatiales	M	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N
k59_981659_2	95619.PM1_0200205	1.23e-105	317.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0050570,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	iECO111_1330.ECO111_0056	PdxA
k59_1862162_1	621372.ACIH01000278_gene847	4.43e-44	158.0	COG3464@1|root,COG3464@2|Bacteria,1UKR8@1239|Firmicutes,4HT0F@91061|Bacilli,26WGG@186822|Paenibacillaceae	91061|Bacilli	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_673777_1	765912.Thimo_1932	1.61e-63	206.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1WWA8@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_1437475_1	1049564.TevJSym_ac01020	3.86e-97	300.0	COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,1RPDG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_145481_1	439235.Dalk_2427	8.25e-07	50.4	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	adiA	-	2.7.7.65,4.1.1.19	ko:K01584,ko:K20955	ko00330,ko01100,ko05111,map00330,map01100,map05111	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,GGDEF,HATPase_c,HisKA,NB-ARC,OKR_DC_1,OKR_DC_1_C,OKR_DC_1_N,Response_reg,TPR_12,dCache_1
k59_145481_2	999411.HMPREF1092_00155	4.6e-58	197.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,36ES8@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	iHN637.CLJU_RS15830	Ala_racemase_C,Ala_racemase_N
k59_276826_1	497964.CfE428DRAFT_2523	1.34e-117	366.0	COG0209@1|root,COG0209@2|Bacteria,46SG4@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
k59_1611432_1	1123253.AUBD01000005_gene67	1.69e-77	245.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1X3HB@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_1553269_1	1121937.AUHJ01000050_gene1243	1.72e-96	293.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,1RMHK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG3385 FOG Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_497215_2	288000.BBta_1180	8.12e-35	126.0	COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,2U7C6@28211|Alphaproteobacteria,3JSG9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides	chaC	-	-	ko:K07232	-	-	-	-	ko00000	-	-	-	ChaC
k59_394177_1	1121403.AUCV01000001_gene874	3.32e-33	122.0	2AVTU@1|root,31MME@2|Bacteria,1NQ7V@1224|Proteobacteria,42XCN@68525|delta/epsilon subdivisions,2WTFJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1729835_1	1165841.SULAR_03817	9.87e-117	365.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2YTAQ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_849566_2	1120999.JONM01000007_gene1811	1.29e-45	154.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,2VRIQ@28216|Betaproteobacteria,2KU2I@206351|Neisseriales	206351|Neisseriales	E	GDSL-like Lipase/Acylhydrolase family	tesA	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
k59_1377353_1	314278.NB231_11579	1.81e-80	242.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,1WVVY@135613|Chromatiales	135613|Chromatiales	E	imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
k59_1437488_1	935839.JAGJ01000006_gene3300	7.49e-172	518.0	COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria,4F38B@85017|Promicromonosporaceae	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_849568_1	1095767.CAHD01000231_gene2889	3.91e-39	144.0	COG0609@1|root,COG0609@2|Bacteria,2GK8Z@201174|Actinobacteria,4F0X3@85016|Cellulomonadaceae	201174|Actinobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
k59_849568_2	471853.Bcav_2582	6.85e-87	266.0	COG0614@1|root,COG0614@2|Bacteria,2GKZJ@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Fe3 -hydroxamate transport system, periplasmic component	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
k59_555810_1	187272.Mlg_2632	1.7e-104	327.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales	135613|Chromatiales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_1377358_2	1303692.SFUL_850	3.53e-34	127.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
k59_213225_1	519989.ECTPHS_01749	7.51e-94	278.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1WX3P@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
k59_408215_1	28444.JODQ01000017_gene6567	4.85e-95	288.0	COG2255@1|root,COG2255@2|Bacteria,2GJZF@201174|Actinobacteria,4EH70@85012|Streptosporangiales	201174|Actinobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_936295_1	765912.Thimo_2416	9.18e-50	181.0	COG0419@1|root,COG4717@1|root,COG0419@2|Bacteria,COG4717@2|Bacteria,1MVAW@1224|Proteobacteria,1RZFW@1236|Gammaproteobacteria,1WX3B@135613|Chromatiales	135613|Chromatiales	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_27
k59_1738909_1	675635.Psed_4235	6.33e-06	56.6	COG0515@1|root,COG0515@2|Bacteria,2IAZC@201174|Actinobacteria,4DXAZ@85010|Pseudonocardiales	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_1738909_2	446469.Sked_15450	8.03e-110	328.0	COG1090@1|root,COG1090@2|Bacteria,2GJS0@201174|Actinobacteria	201174|Actinobacteria	S	epimerase	-	GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0030312,GO:0031073,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0046906,GO:0048037,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
k59_1562359_1	317025.Tcr_2140	1.37e-85	264.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1S2WF@1236|Gammaproteobacteria,46277@72273|Thiotrichales	72273|Thiotrichales	C	Iron-containing alcohol dehydrogenase	-	-	1.1.3.48	ko:K19714	-	-	R11394	RC03427	ko00000,ko01000,ko01005	-	-	-	Fe-ADH
k59_1562359_2	1216362.B437_00165	4.6e-12	66.2	COG1212@1|root,COG1212@2|Bacteria,378DT@32066|Fusobacteria	32066|Fusobacteria	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
k59_1681287_1	1078020.KEK_00685	1.27e-19	93.2	COG2207@1|root,COG2207@2|Bacteria,2IBP1@201174|Actinobacteria,233Z0@1762|Mycobacteriaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding_2,HTH_18
k59_1348093_1	187272.Mlg_1393	1.14e-149	436.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1WX2I@135613|Chromatiales	135613|Chromatiales	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
k59_114730_1	1249480.B649_09140	2.26e-99	305.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2YM7I@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	iIT341.HP0354	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_154878_1	1173264.KI913949_gene2513	1.89e-43	159.0	COG0025@1|root,COG0025@2|Bacteria,1G1WP@1117|Cyanobacteria,1H96B@1150|Oscillatoriales	1117|Cyanobacteria	P	TIGRFAM Na H antiporter, bacterial form	-	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042592,GO:0044464,GO:0046873,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098719,GO:0098739,GO:0098771,GO:0099516,GO:0099587,GO:1902600	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
k59_564810_1	1089453.GOSPT_052_00290	1.92e-20	93.6	COG1307@1|root,COG1307@2|Bacteria,2GIUV@201174|Actinobacteria,4GAKX@85026|Gordoniaceae	201174|Actinobacteria	S	Uncharacterised protein, DegV family COG1307	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DegV
k59_1446294_1	1032480.MLP_31930	1.31e-108	344.0	COG1190@1|root,COG2898@1|root,COG1190@2|Bacteria,COG2898@2|Bacteria,2GKE0@201174|Actinobacteria,4DQ4F@85009|Propionibacteriales	201174|Actinobacteria	J	Uncharacterised conserved protein (DUF2156)	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DUF2156,tRNA-synt_2,tRNA-synt_2_TM,tRNA_anti-codon
k59_1795093_1	1266914.ATUK01000013_gene1893	2.2e-83	259.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1WXIX@135613|Chromatiales	135613|Chromatiales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_995581_1	1120950.KB892759_gene6292	1.05e-18	79.3	COG2835@1|root,COG2835@2|Bacteria,2HUT7@201174|Actinobacteria,4DSPV@85009|Propionibacteriales	201174|Actinobacteria	S	Trm112p-like protein	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
k59_995581_2	1121933.AUHH01000001_gene2113	2.45e-56	189.0	COG1737@1|root,COG1737@2|Bacteria,2GMG0@201174|Actinobacteria,4DMZS@85009|Propionibacteriales	201174|Actinobacteria	K	Bacterial phospho-glucose isomerase C-terminal SIS domain	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	bact-PGI_C
k59_56291_1	1286106.MPL1_06632	1.53e-93	297.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,46054@72273|Thiotrichales	72273|Thiotrichales	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_1738931_1	1121015.N789_00760	3.51e-29	122.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1S6X1@1236|Gammaproteobacteria,1X450@135614|Xanthomonadales	135614|Xanthomonadales	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
k59_408266_1	1336245.JAGO01000015_gene2092	3.29e-44	155.0	COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,1RS1U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	acetyltransferase	yghO	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	-
k59_447609_1	1095769.CAHF01000013_gene3259	1.91e-41	154.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,4726K@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Domain of unknown function (DUF3488)	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
k59_1511768_1	933262.AXAM01000009_gene1486	1.29e-66	209.0	COG1028@1|root,COG1028@2|Bacteria,1R7KW@1224|Proteobacteria,42NF5@68525|delta/epsilon subdivisions,2WM4D@28221|Deltaproteobacteria,2MIF5@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_623440_1	1283287.KB822579_gene2177	1.03e-61	202.0	COG1808@1|root,COG1808@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
k59_1795112_1	394221.Mmar10_0334	4.44e-47	174.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43XNB@69657|Hyphomonadaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2,TPR_16,TPR_8,Trans_reg_C
k59_936356_1	1249627.D779_0440	5.1e-69	228.0	COG1018@1|root,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,1T2FP@1236|Gammaproteobacteria,1WWXW@135613|Chromatiales	135613|Chromatiales	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2
k59_1103053_1	1121296.JONJ01000011_gene44	1.85e-36	135.0	COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,21Z1Z@1506553|Lachnoclostridium	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
k59_1446323_2	1123507.ATVQ01000001_gene1402	1.01e-24	99.4	COG2860@1|root,COG2860@2|Bacteria,2GMI4@201174|Actinobacteria,1W8YW@1268|Micrococcaceae	201174|Actinobacteria	S	UPF0126 domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	UPF0126
k59_1147913_1	1122599.AUGR01000038_gene3252	5.62e-84	271.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1XHEE@135619|Oceanospirillales	135619|Oceanospirillales	P	Chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Voltage_CLC
k59_56328_1	367299.JOEE01000007_gene184	1.16e-54	191.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4FF0B@85021|Intrasporangiaceae	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1620582_1	590998.Celf_2356	3.28e-179	510.0	COG0635@1|root,COG0635@2|Bacteria,2GJXX@201174|Actinobacteria,4F24S@85016|Cellulomonadaceae	201174|Actinobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	iNJ661.Rv2388c	HemN_C,Radical_SAM
k59_506310_1	1248760.ANFZ01000018_gene606	4.81e-24	99.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,2U70Y@28211|Alphaproteobacteria,2K3X3@204457|Sphingomonadales	204457|Sphingomonadales	L	Methyltransferase	-	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
k59_1030182_2	205918.Psyr_0838	5.78e-31	114.0	COG2146@1|root,COG2146@2|Bacteria,1N72F@1224|Proteobacteria,1SD0G@1236|Gammaproteobacteria,1Z822@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_1211141_1	875328.JDM601_1387	3.68e-12	63.5	COG1225@1|root,COG1225@2|Bacteria,2IHZ6@201174|Actinobacteria,235NM@1762|Mycobacteriaceae	201174|Actinobacteria	O	Peroxiredoxin	bcp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_936401_1	314285.KT71_10322	6.22e-42	142.0	COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,1S8WT@1236|Gammaproteobacteria,1JA2P@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Stringent starvation protein B	sspB	GO:0000502,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0009376,GO:0009893,GO:0009894,GO:0009896,GO:0010604,GO:0019222,GO:0019899,GO:0031597,GO:0032781,GO:0032991,GO:0042176,GO:0042802,GO:0042803,GO:0043085,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043462,GO:0044093,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045732,GO:0046983,GO:0048518,GO:0050789,GO:0050790,GO:0051117,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051336,GO:0051345,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:1901363,GO:1902494,GO:1904949,GO:1905368,GO:1905369,GO:1990904	-	ko:K03600	-	-	-	-	ko00000,ko03021	-	-	-	SspB
k59_1348196_1	686340.Metal_1191	4.59e-46	163.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1XE18@135618|Methylococcales	135618|Methylococcales	O	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_564889_2	748247.AZKH_0540	3.32e-46	155.0	COG5588@1|root,COG5588@2|Bacteria,1MWK3@1224|Proteobacteria,2VMAI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1326
k59_1277632_1	522306.CAP2UW1_3226	4.43e-87	270.0	COG4942@1|root,COG4942@2|Bacteria,1MXRZ@1224|Proteobacteria,2VN9G@28216|Betaproteobacteria	28216|Betaproteobacteria	D	Protein of unknown function (DUF3375)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3375
k59_408354_1	471853.Bcav_2545	8.45e-54	187.0	COG2844@1|root,COG2844@2|Bacteria,2GMKT@201174|Actinobacteria	201174|Actinobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_330729_1	479432.Sros_6027	1.33e-28	120.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4EH5P@85012|Streptosporangiales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,GerE,NB-ARC,Trans_reg_C
k59_1446364_1	584708.Apau_0233	2.83e-06	48.5	COG3383@1|root,COG3383@2|Bacteria,3TAJC@508458|Synergistetes	2|Bacteria	C	Molydopterin dinucleotide binding domain	-	-	1.17.1.10,1.17.1.9	ko:K00123,ko:K05299	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1446364_2	338963.Pcar_1843	4.9e-35	135.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,43VZE@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.10,1.17.1.9	ko:K00123,ko:K05299	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1562448_1	443143.GM18_3518	1.65e-99	314.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,42MFX@68525|delta/epsilon subdivisions,2WJ91@28221|Deltaproteobacteria,43T6C@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_506350_1	1397528.Q671_16430	5.21e-72	227.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,1XHH6@135619|Oceanospirillales	135619|Oceanospirillales	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroF-1	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
k59_56374_1	357808.RoseRS_1075	6.06e-21	96.7	COG0577@1|root,COG0577@2|Bacteria,2G68F@200795|Chloroflexi,376ZY@32061|Chloroflexia	32061|Chloroflexia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1681375_1	550540.Fbal_0478	2.31e-62	210.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,1RNH4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	ybaL	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
k59_683234_1	420324.KI912006_gene8659	5.44e-115	354.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria,1JTBI@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM biotin lipoyl attachment domain-containing protein	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
k59_1562453_1	635013.TherJR_0997	3.46e-23	103.0	COG0395@1|root,COG5001@1|root,COG5002@1|root,COG0395@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,26021@186807|Peptococcaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_8,PAS_9
k59_154971_1	717785.HYPMC_2075	1.26e-105	316.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2TQS1@28211|Alphaproteobacteria,3N6I4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phospho-acceptor) domain	ntrB	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
k59_683236_1	396588.Tgr7_1157	4.73e-172	512.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales	135613|Chromatiales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2
k59_1446376_1	335543.Sfum_3369	1.94e-72	243.0	COG4581@1|root,COG4581@2|Bacteria,1QUPR@1224|Proteobacteria,42NSH@68525|delta/epsilon subdivisions,2WKD7@28221|Deltaproteobacteria,2MQUA@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DSHCT	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,DSHCT,DUF3516,Helicase_C
k59_995720_1	1122180.Lokhon_02822	2.3e-24	100.0	COG0494@1|root,COG0494@2|Bacteria,1MZ5D@1224|Proteobacteria,2UBX9@28211|Alphaproteobacteria,2P91S@245186|Loktanella	28211|Alphaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_741899_1	519989.ECTPHS_07267	2.59e-107	330.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1WW27@135613|Chromatiales	135613|Chromatiales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_936466_1	717785.HYPMC_4756	7.74e-133	382.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2TSU4@28211|Alphaproteobacteria,3N7R0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_858408_1	573413.Spirs_0347	7.58e-105	308.0	COG0410@1|root,COG0410@2|Bacteria,2J5VQ@203691|Spirochaetes	203691|Spirochaetes	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_1147969_1	675635.Psed_2213	2.02e-08	57.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4E1A0@85010|Pseudonocardiales	201174|Actinobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB2	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1147969_2	984262.SGRA_1178	1.47e-13	72.8	COG0484@1|root,COG0484@2|Bacteria,4NF41@976|Bacteroidetes,1IQ7V@117747|Sphingobacteriia	976|Bacteroidetes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_1621554_1	204669.Acid345_4500	9.13e-33	128.0	COG1228@1|root,COG1228@2|Bacteria,3Y69U@57723|Acidobacteria,2JMB0@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_859290_1	96561.Dole_0021	2.02e-18	83.6	COG0637@1|root,COG0637@2|Bacteria,1QW0J@1224|Proteobacteria,43BQD@68525|delta/epsilon subdivisions,2X71F@28221|Deltaproteobacteria,2MPIT@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_1278662_1	631362.Thi970DRAFT_00599	1.03e-95	295.0	COG4467@1|root,COG4467@2|Bacteria,1PPMF@1224|Proteobacteria,1S1PB@1236|Gammaproteobacteria,1WY6Q@135613|Chromatiales	135613|Chromatiales	S	COG3436 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
k59_155973_1	1121930.AQXG01000014_gene370	1.65e-55	187.0	COG2355@1|root,COG2355@2|Bacteria,4NEBG@976|Bacteroidetes,1IQAA@117747|Sphingobacteriia	976|Bacteroidetes	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273,ko:K01274	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_C26,Peptidase_M19
k59_331764_1	1265505.ATUG01000002_gene2050	3.33e-16	81.3	COG3063@1|root,COG3063@2|Bacteria,1RK88@1224|Proteobacteria,42SIP@68525|delta/epsilon subdivisions,2WPT7@28221|Deltaproteobacteria,2MK0U@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Tetratricopeptide repeat	tgl	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8
k59_214277_1	1322246.BN4_20338	2.15e-23	97.8	COG0517@1|root,COG0517@2|Bacteria,1MYKI@1224|Proteobacteria,42SME@68525|delta/epsilon subdivisions,2WPWE@28221|Deltaproteobacteria,2MB6V@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_1512849_2	1354722.JQLS01000008_gene1659	2.63e-16	78.2	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,46P8D@74030|Roseovarius	28211|Alphaproteobacteria	E	COG0411 ABC-type branched-chain amino acid transport systems, ATPase component	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_794638_2	1247726.MIM_c25100	7.05e-36	131.0	COG0500@1|root,COG2226@2|Bacteria,1RFPW@1224|Proteobacteria,2VRVY@28216|Betaproteobacteria,3T6FR@506|Alcaligenaceae	28216|Betaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_1512851_1	1304865.JAGF01000001_gene2616	6.5e-106	307.0	COG0262@1|root,COG0262@2|Bacteria,2GKX0@201174|Actinobacteria	201174|Actinobacteria	H	bifunctional deaminase-reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_1104216_1	1380394.JADL01000001_gene3072	4.87e-88	269.0	COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2TR20@28211|Alphaproteobacteria,2JPF7@204441|Rhodospirillales	204441|Rhodospirillales	H	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
k59_290268_1	382464.ABSI01000006_gene815	1.64e-69	239.0	COG0771@1|root,COG2911@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,46UDY@74201|Verrucomicrobia,2IWGN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	Q	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1682336_1	1157708.KB907454_gene2919	3.35e-80	241.0	COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,2VIJ0@28216|Betaproteobacteria,4AAK0@80864|Comamonadaceae	28216|Betaproteobacteria	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
k59_1387614_1	1415778.JQMM01000001_gene866	1.86e-07	54.3	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,1J5FI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Peptidoglycan polymerase that is essential for cell division	ftsW	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_1387614_2	864563.HMPREF9166_1039	4.33e-11	66.2	COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,4H30K@909932|Negativicutes	909932|Negativicutes	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	AlaDh_PNT_C,Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_872392_1	1906.SFRA_23340	1.82e-22	99.8	COG2234@1|root,COG4935@1|root,COG2234@2|Bacteria,COG4935@2|Bacteria,2GIT0@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase, M28	-	-	3.4.11.24	ko:K19702	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	P_proprotein,Peptidase_M28
k59_1399275_1	765913.ThidrDRAFT_0539	5.59e-11	63.2	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1WWIC@135613|Chromatiales	135613|Chromatiales	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
k59_1399275_2	452637.Oter_2961	7.12e-18	79.0	COG1925@1|root,COG1925@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	ptsH	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005981,GO:0006109,GO:0006793,GO:0006796,GO:0006810,GO:0008047,GO:0008150,GO:0008152,GO:0008643,GO:0008965,GO:0008982,GO:0009401,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010604,GO:0010675,GO:0010676,GO:0010906,GO:0010907,GO:0015144,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0019197,GO:0019222,GO:0022804,GO:0022857,GO:0030234,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032881,GO:0032991,GO:0034219,GO:0043085,GO:0043467,GO:0043470,GO:0043471,GO:0044093,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045819,GO:0045913,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051179,GO:0051234,GO:0055085,GO:0060255,GO:0062012,GO:0062013,GO:0065007,GO:0065009,GO:0070873,GO:0070875,GO:0071702,GO:0080090,GO:0098772	-	ko:K02784,ko:K11189	ko02060,map02060	-	-	-	ko00000,ko00001,ko02000	4.A.2.1,8.A.8.1.1	-	e_coli_core.b2415,iAF1260.b2415,iB21_1397.B21_02276,iBWG_1329.BWG_2177,iE2348C_1286.E2348C_2601,iEC042_1314.EC042_2624,iEC55989_1330.EC55989_2705,iECABU_c1320.ECABU_c27360,iECBD_1354.ECBD_1266,iECB_1328.ECB_02315,iECDH10B_1368.ECDH10B_2580,iECDH1ME8569_1439.ECDH1ME8569_2349,iECDH1ME8569_1439.EcDH1_1246,iECD_1391.ECD_02315,iECED1_1282.ECED1_2859,iECH74115_1262.ECH74115_3646,iECIAI1_1343.ECIAI1_2473,iECIAI39_1322.ECIAI39_2561,iECNA114_1301.ECNA114_2492,iECO103_1326.ECO103_2934,iECO111_1330.ECO111_3145,iECO26_1355.ECO26_3468,iECOK1_1307.ECOK1_2732,iECP_1309.ECP_2439,iECS88_1305.ECS88_2605,iECSE_1348.ECSE_2706,iECSF_1327.ECSF_2279,iECSP_1301.ECSP_3363,iECUMN_1333.ECUMN_2737,iECW_1372.ECW_m2644,iECs_1301.ECs3287,iEKO11_1354.EKO11_1313,iETEC_1333.ETEC_2528,iEcDH1_1363.EcDH1_1246,iEcE24377_1341.EcE24377A_2702,iEcHS_1320.EcHS_A2550,iEcSMS35_1347.EcSMS35_2570,iEcolC_1368.EcolC_1263,iG2583_1286.G2583_2947,iJO1366.b2415,iJR904.b2415,iLF82_1304.LF82_1769,iNRG857_1313.NRG857_12110,iPC815.YPO2993,iSBO_1134.SBO_2439,iSDY_1059.SDY_2612,iSFV_1184.SFV_2467,iSF_1195.SF2470,iSFxv_1172.SFxv_2719,iSSON_1240.SSON_2504,iS_1188.S2616,iSbBS512_1146.SbBS512_E2765,iUMN146_1321.UM146_04545,iUMNK88_1353.UMNK88_3017,iUTI89_1310.UTI89_C2749,iWFL_1372.ECW_m2644,iY75_1357.Y75_RS12655,iZ_1308.Z3681,ic_1306.c2950	PTS-HPr
k59_459204_1	1158756.AQXQ01000009_gene1049	5.45e-60	209.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWJ6@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1805835_1	269800.Tfu_0971	5.76e-71	241.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,2GN30@201174|Actinobacteria	201174|Actinobacteria	V	DNA restriction-modification system	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
k59_754845_1	1283300.ATXB01000002_gene3167	1.05e-104	322.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1XDMF@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_1459618_1	909943.HIMB100_00016930	5.15e-30	113.0	COG1028@1|root,COG1028@2|Bacteria,1MXTP@1224|Proteobacteria,2TQST@28211|Alphaproteobacteria,4BPAQ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.175	ko:K22185	ko00040,map00040	-	R01429	RC00066	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
k59_1224457_1	765911.Thivi_0952	8.43e-30	120.0	COG3278@1|root,COG3278@2|Bacteria,1P8T0@1224|Proteobacteria,1T4ST@1236|Gammaproteobacteria,1WW05@135613|Chromatiales	135613|Chromatiales	O	Belongs to the heme-copper respiratory oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_225923_1	870187.Thini_2000	1.86e-70	218.0	COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,1S302@1236|Gammaproteobacteria,462CF@72273|Thiotrichales	72273|Thiotrichales	C	Protein of unknown function (DUF3501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
k59_225923_2	1049564.TevJSym_bd00260	7.21e-100	302.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1J7KN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cysteine-rich domain	glpC	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944	1.1.5.3	ko:K00113,ko:K11473	ko00564,ko00630,ko01100,ko01110,ko01120,ko01130,map00564,map00630,map01100,map01110,map01120,map01130	-	R00475,R00848	RC00029,RC00042	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
k59_1459623_1	96561.Dole_0916	1.5e-64	209.0	COG0577@1|root,COG0577@2|Bacteria,1R6DP@1224|Proteobacteria,42PWX@68525|delta/epsilon subdivisions,2WJSB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1459633_1	999541.bgla_1g02650	1.8e-86	284.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,1K37E@119060|Burkholderiaceae	28216|Betaproteobacteria	C	oxidoreductase	porG	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
k59_1459633_2	566466.NOR53_2334	1.04e-126	377.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1J7HN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_872446_1	765911.Thivi_1267	1.2e-79	246.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1WXDA@135613|Chromatiales	135613|Chromatiales	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
k59_1224481_1	1121937.AUHJ01000010_gene1683	4.16e-16	78.2	COG3126@1|root,COG3126@2|Bacteria,1N8AF@1224|Proteobacteria,1SCM7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	ybaY	-	-	ko:K09914	-	-	-	-	ko00000	-	-	-	YscW
k59_695366_1	1231391.AMZF01000003_gene3152	6.4e-19	84.0	COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,2VIX0@28216|Betaproteobacteria,3T23I@506|Alcaligenaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF455)	-	-	-	-	-	-	-	-	-	-	-	-	DUF455
k59_1399328_1	765911.Thivi_4102	8.48e-103	303.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1WW30@135613|Chromatiales	135613|Chromatiales	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
k59_1694752_1	1286631.X805_13670	5.67e-21	93.2	COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,2VMHY@28216|Betaproteobacteria,1KM3P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	periplasmic binding protein LacI transcriptional regulator	scrR	-	-	ko:K02529,ko:K03484	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
k59_635576_1	880072.Desac_1143	5.39e-81	265.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MQB6@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_343495_1	1386969.AWTB01000020_gene950	2.76e-126	366.0	COG2801@1|root,COG2801@2|Bacteria,2GKDY@201174|Actinobacteria,4GC82@85026|Gordoniaceae	201174|Actinobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_872470_1	1162668.LFE_0098	1.88e-101	310.0	COG2801@1|root,COG2801@2|Bacteria,3J1E8@40117|Nitrospirae	2|Bacteria	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve
k59_459273_1	243233.MCA2079	2.65e-73	232.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1XECU@135618|Methylococcales	135618|Methylococcales	E	PFAM Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1226568_1	1123257.AUFV01000004_gene789	3.71e-75	237.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RV50@1236|Gammaproteobacteria,1X5AH@135614|Xanthomonadales	135614|Xanthomonadales	I	Thiolase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
k59_874738_1	382464.ABSI01000021_gene411	4.36e-84	266.0	COG3604@1|root,COG3604@2|Bacteria,46YU4@74201|Verrucomicrobia,2IVAR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KT	Bacterial regulatory protein, Fis family	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_8,Sigma54_activat
k59_637166_1	1132855.KB913035_gene1500	1.08e-29	120.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria	28216|Betaproteobacteria	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
k59_1160749_2	1267005.KB911258_gene635	4.67e-62	194.0	COG0785@1|root,COG0785@2|Bacteria,1RCP7@1224|Proteobacteria,2TSAI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Cytochrome c biogenesis protein	soxV	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
k59_169844_1	768671.ThimaDRAFT_3349	4.04e-122	359.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1WW0I@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_1226583_2	344747.PM8797T_17709	8.39e-29	117.0	COG1757@1|root,COG1757@2|Bacteria,2IX89@203682|Planctomycetes	203682|Planctomycetes	C	COG1757 Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
k59_1047565_1	765910.MARPU_08555	4.93e-64	209.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,1WVZV@135613|Chromatiales	135613|Chromatiales	P	PFAM Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1047565_2	1038862.KB893867_gene5110	2.12e-15	75.5	COG0560@1|root,COG0560@2|Bacteria,1MW38@1224|Proteobacteria,2TVAB@28211|Alphaproteobacteria,3JUMP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
k59_1636143_2	1269813.ATUL01000009_gene1683	2.09e-15	71.2	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	DUF836,Thioredoxin
k59_1401459_2	877424.ATWC01000029_gene1670	1.07e-06	57.4	COG1216@1|root,COG1216@2|Bacteria,1VBEV@1239|Firmicutes,24TJA@186801|Clostridia,27M96@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_227846_1	96561.Dole_0565	1.97e-106	319.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42MFT@68525|delta/epsilon subdivisions,2WIXC@28221|Deltaproteobacteria,2MHRV@213118|Desulfobacterales	28221|Deltaproteobacteria	P	TIGRFAM ammonium transporter	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_1160770_1	367299.JOEE01000001_gene1790	6.37e-14	68.9	COG0586@1|root,COG0586@2|Bacteria,2IA3P@201174|Actinobacteria,4FGJV@85021|Intrasporangiaceae	201174|Actinobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_1160770_2	1120959.ATXF01000006_gene1866	4.05e-42	149.0	COG2021@1|root,COG2021@2|Bacteria,2IMKC@201174|Actinobacteria,4FQP1@85023|Microbacteriaceae	201174|Actinobacteria	E	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Hydrolase_4
k59_578180_1	335543.Sfum_2794	1.29e-86	268.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,2MQ4Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	ferredoxin oxidoreductase alpha subunit	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_578180_2	161156.JQKW01000007_gene676	5.8e-33	122.0	COG1013@1|root,COG1013@2|Bacteria,2GHBX@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_1807525_2	1125973.JNLC01000013_gene3988	2.18e-17	85.1	COG0697@1|root,COG0697@2|Bacteria,1MXVF@1224|Proteobacteria,2TU7N@28211|Alphaproteobacteria,3K4DE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_169876_2	1049564.TevJSym_aa00130	1.51e-52	167.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,1S973@1236|Gammaproteobacteria,1J6C1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
k59_1226618_1	2340.JV46_28000	6.83e-73	229.0	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,1J545@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex	ccoP	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
k59_874800_1	529709.PYCH_03550	1e-36	137.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTX2@28890|Euryarchaeota,242XP@183968|Thermococci	183968|Thermococci	O	AIR synthase related protein, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
k59_1401488_2	765911.Thivi_0663	3.03e-77	233.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S9S6@1236|Gammaproteobacteria,1WY94@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_1752975_1	593907.Celgi_0844	1.5e-43	145.0	COG0203@1|root,COG0203@2|Bacteria,2IHV2@201174|Actinobacteria,4F1Z2@85016|Cellulomonadaceae	201174|Actinobacteria	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
k59_1752975_2	1283283.ATXA01000007_gene3948	1.58e-39	140.0	COG0202@1|root,COG0202@2|Bacteria,2GJJ5@201174|Actinobacteria,4ES1P@85013|Frankiales	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_1578127_1	1215092.PA6_027_01250	4.76e-22	94.4	COG4795@1|root,COG4795@2|Bacteria,1RJAE@1224|Proteobacteria,1S5ZZ@1236|Gammaproteobacteria,1YG2B@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	U	Type II secretion system (T2SS), protein J	gspJ	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSJ
k59_227875_1	396588.Tgr7_2074	9.11e-144	429.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1WWAD@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_461029_1	1131553.JIBI01000032_gene2309	1.63e-28	119.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2VK3I@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Chloride channel	clcA_1	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
k59_1160812_1	278957.ABEA03000201_gene4320	2.41e-45	169.0	COG2804@1|root,COG2804@2|Bacteria,46UIY@74201|Verrucomicrobia,3K7E3@414999|Opitutae	414999|Opitutae	NU	Secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_578224_1	288705.RSal33209_2986	1.41e-49	167.0	COG1825@1|root,COG1825@2|Bacteria,2GJPJ@201174|Actinobacteria,1W8Y3@1268|Micrococcaceae	201174|Actinobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_518578_1	933262.AXAM01000029_gene2746	6.95e-90	278.0	COG4656@1|root,COG4656@2|Bacteria,1QMZ4@1224|Proteobacteria,42NJ5@68525|delta/epsilon subdivisions,2WKCG@28221|Deltaproteobacteria,2MIQX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,RnfC_N
k59_1636210_1	1033730.CAHG01000016_gene342	1.67e-85	267.0	COG0733@1|root,COG0733@2|Bacteria,2GIU3@201174|Actinobacteria,4DPED@85009|Propionibacteriales	201174|Actinobacteria	S	Sodium:neurotransmitter symporter family	metP	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_1461468_1	1049564.TevJSym_ac00140	1.78e-30	121.0	COG1999@1|root,COG4531@1|root,COG1999@2|Bacteria,COG4531@2|Bacteria,1RHJ8@1224|Proteobacteria,1SYEA@1236|Gammaproteobacteria,1J6I1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC,ZnuA
k59_1461468_2	1255043.TVNIR_3015	1.61e-29	112.0	COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,1SCJD@1236|Gammaproteobacteria,1WYZ4@135613|Chromatiales	135613|Chromatiales	S	Copper chaperone PCu(A)C	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	PCuAC
k59_461042_1	631362.Thi970DRAFT_03923	6.9e-50	173.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1WX73@135613|Chromatiales	135613|Chromatiales	M	PFAM Three-deoxy-D-manno-octulosonic-acid transferase	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N,Kdo
k59_461042_2	1255043.TVNIR_2697	4.97e-84	264.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1WWQB@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
k59_1753012_1	452637.Oter_1382	2.43e-104	317.0	COG2160@1|root,COG2160@2|Bacteria,46UVN@74201|Verrucomicrobia,3K78V@414999|Opitutae	414999|Opitutae	G	Catalyzes the conversion of L-arabinose to L-ribulose	araA	-	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	-	Arabinose_Iso_C,Arabinose_Isome
k59_461045_2	530564.Psta_4032	8.43e-45	160.0	COG1912@1|root,COG1912@2|Bacteria,2IZNZ@203682|Planctomycetes	203682|Planctomycetes	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
k59_1047655_1	1267005.KB911265_gene3584	1.74e-82	256.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,2TR6W@28211|Alphaproteobacteria,3N68X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_1578174_1	644282.Deba_0864	6.88e-89	275.0	COG1215@1|root,COG1215@2|Bacteria,1MWH9@1224|Proteobacteria,42PX0@68525|delta/epsilon subdivisions,2WJUG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	-
k59_578250_1	669262.COK_2329	1.7e-19	91.3	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1Y7W7@135625|Pasteurellales	135625|Pasteurellales	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_1578182_1	639283.Snov_1120	1.63e-91	285.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2TR9U@28211|Alphaproteobacteria,3EZ32@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_1047666_1	768671.ThimaDRAFT_3963	8.38e-73	227.0	COG0084@1|root,COG0084@2|Bacteria,1MW5C@1224|Proteobacteria,1RP5T@1236|Gammaproteobacteria,1WWHE@135613|Chromatiales	135613|Chromatiales	L	hydrolase, TatD family	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
k59_1636246_1	543632.JOJL01000004_gene4389	1.85e-56	182.0	COG2318@1|root,COG2318@2|Bacteria,2HUJD@201174|Actinobacteria,4DEMM@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
k59_1636246_2	6500.XP_005089019.1	1.46e-08	55.8	COG1720@1|root,KOG2942@2759|Eukaryota,38FMK@33154|Opisthokonta,3BAF0@33208|Metazoa,3D2P4@33213|Bilateria	33208|Metazoa	V	tRNA (adenine-N6-)-methyltransferase activity	C9orf156	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016426,GO:0016430,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	-	-	-	-	-	-	-	-	-	-	UPF0066
k59_578261_1	82508.K1VDR3	4.77e-22	97.1	COG1250@1|root,KOG2304@2759|Eukaryota	2759|Eukaryota	I	3-hydroxyacyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N,zf-C3HC4_3
k59_1226707_1	258052.JNYV01000003_gene5066	4.93e-38	140.0	COG4992@1|root,COG4992@2|Bacteria,2GKE9@201174|Actinobacteria,2M0MD@2063|Kitasatospora	201174|Actinobacteria	E	Aminotransferase class-III	-	-	2.6.1.13,2.6.1.82	ko:K00819,ko:K09251	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667,R01155	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_1578196_1	717785.HYPMC_0533	2.94e-56	188.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,2TR6W@28211|Alphaproteobacteria,3N68X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_1697013_1	1469245.JFBG01000020_gene1082	2.33e-113	337.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1WXB6@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_1636260_2	1267005.KB911263_gene1335	9.39e-35	127.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2TSMS@28211|Alphaproteobacteria,3N6K3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
k59_1401575_1	859657.RPSI07_2244	5.28e-05	48.5	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,2VI8B@28216|Betaproteobacteria,1K4UW@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
k59_1401575_2	1492922.GY26_18045	2.83e-26	104.0	COG1489@1|root,COG1489@2|Bacteria,1MUC3@1224|Proteobacteria,1RQ95@1236|Gammaproteobacteria,1J5WH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the SfsA family	sfsA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005975,GO:0006355,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0044238,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K06206	-	-	-	-	ko00000	-	-	-	SfsA
k59_345389_1	1380370.JIBA01000015_gene172	8.71e-128	372.0	COG0050@1|root,COG0050@2|Bacteria,2GK4T@201174|Actinobacteria,4FFNY@85021|Intrasporangiaceae	201174|Actinobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0019899,GO:0030312,GO:0035375,GO:0036293,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_1807628_2	396588.Tgr7_0954	2.9e-21	93.2	COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,1RS4G@1236|Gammaproteobacteria,1WXQH@135613|Chromatiales	135613|Chromatiales	Q	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_461095_1	991905.SL003B_0564	5.87e-155	452.0	COG4263@1|root,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,2TTB5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide	nosZ	-	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	COX2,Cupredoxin_1
k59_169999_1	1335760.ASTG01000016_gene119	1.55e-65	216.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,2K6JI@204457|Sphingomonadales	204457|Sphingomonadales	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2,TPR_8,Trans_reg_C
k59_637304_1	493475.GARC_2471	1.52e-36	129.0	COG3339@1|root,COG3339@2|Bacteria,1RAN7@1224|Proteobacteria,1S291@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Conserved Protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
k59_1697059_1	367299.JOEE01000003_gene3045	1.57e-92	277.0	COG3483@1|root,COG3483@2|Bacteria,2GNB1@201174|Actinobacteria,4FE93@85021|Intrasporangiaceae	201174|Actinobacteria	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
k59_757021_1	83406.HDN1F_14160	4.26e-43	154.0	COG2866@1|root,COG2866@2|Bacteria,1N6CX@1224|Proteobacteria,1RZAW@1236|Gammaproteobacteria,1J9GJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Protein of unknown function (DUF2817)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2817
k59_708653_2	1049564.TevJSym_au00330	1.15e-29	119.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,1S4M3@1236|Gammaproteobacteria,1J5J7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	hbpA	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
k59_1001675_1	1172188.KB911823_gene408	1.77e-59	201.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,2GK62@201174|Actinobacteria,4FFVK@85021|Intrasporangiaceae	201174|Actinobacteria	KOT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3,Response_reg
k59_649958_1	1205753.A989_14627	1e-07	54.3	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,1RZ95@1236|Gammaproteobacteria,1X3T7@135614|Xanthomonadales	135614|Xanthomonadales	P	transport protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_649958_2	478741.JAFS01000002_gene392	1.19e-22	98.6	COG5000@1|root,COG5000@2|Bacteria,46S9Q@74201|Verrucomicrobia,37FXN@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	T	PAS domain	ntrB	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
k59_358638_2	1049564.TevJSym_ah00740	3.72e-155	444.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1J4WF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_591359_2	485913.Krac_2911	1.43e-29	120.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,2G7G9@200795|Chloroflexi	200795|Chloroflexi	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,TrkA_C,Voltage_CLC
k59_121623_1	1380370.JIBA01000012_gene3657	2.68e-142	422.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria,4FFSY@85021|Intrasporangiaceae	201174|Actinobacteria	G	Fibronectin type III-like domain	bgl2	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_1530273_1	96561.Dole_0005	1.97e-71	233.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,42NA6@68525|delta/epsilon subdivisions,2WIMU@28221|Deltaproteobacteria,2MJ6H@213118|Desulfobacterales	28221|Deltaproteobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_1298018_1	446471.Xcel_3426	4.44e-45	166.0	COG1652@1|root,COG3629@1|root,COG1652@2|Bacteria,COG3629@2|Bacteria,2I8YV@201174|Actinobacteria,4F544@85017|Promicromonosporaceae	201174|Actinobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,LysM
k59_1826137_1	1288298.rosmuc_01637	1.92e-10	61.2	2DG8R@1|root,2ZUYV@2|Bacteria,1RG4Q@1224|Proteobacteria,2U6V3@28211|Alphaproteobacteria,46PSZ@74030|Roseovarius	28211|Alphaproteobacteria	H	Sulfotransferase family	-	-	2.8.2.2	ko:K01015	ko00140,map00140	-	R00629,R03405,R08977,R08978	RC00007,RC00231,RC00341	ko00000,ko00001,ko01000	-	-	-	Sulfotransfer_1
k59_1826137_2	570952.ATVH01000015_gene1185	1.54e-23	99.4	COG3660@1|root,COG3660@2|Bacteria,1R70U@1224|Proteobacteria,2TQWV@28211|Alphaproteobacteria,2JTHZ@204441|Rhodospirillales	204441|Rhodospirillales	M	Mitochondrial fission ELM1	-	-	-	ko:K07276	-	-	-	-	ko00000	-	-	-	Mito_fiss_Elm1
k59_886960_1	580332.Slit_1752	8.65e-07	49.7	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,2VKKI@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_886960_2	292415.Tbd_1536	8.37e-88	267.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2VJ5G@28216|Betaproteobacteria,1KRK3@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
k59_886960_3	983545.Glaag_4462	6.32e-11	63.2	COG0398@1|root,COG0398@2|Bacteria,1RDYV@1224|Proteobacteria,1SA20@1236|Gammaproteobacteria,469IB@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_825759_1	1304883.KI912532_gene1045	1.93e-87	273.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI5E@28216|Betaproteobacteria,2KUQW@206389|Rhodocyclales	206389|Rhodocyclales	P	nitrite transporter	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
k59_591369_2	927658.AJUM01000034_gene466	3.86e-42	143.0	COG1376@1|root,COG1376@2|Bacteria,4P35B@976|Bacteroidetes	976|Bacteroidetes	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_766808_1	595460.RRSWK_04778	1.56e-40	154.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12,TPR_8
k59_414905_1	1463845.JOIG01000009_gene2843	7.3e-47	165.0	COG0122@1|root,COG0122@2|Bacteria,2GP69@201174|Actinobacteria	201174|Actinobacteria	L	3-methyladenine DNA glycosylase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_5596_1	1499967.BAYZ01000030_gene1158	9.47e-47	162.0	COG0436@1|root,COG0436@2|Bacteria,2NP1C@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase	aspB	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_5596_2	1089551.KE386572_gene4234	1.2e-10	61.2	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,2U5E5@28211|Alphaproteobacteria,4BQ5A@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
k59_1237108_1	377629.TERTU_0384	2.19e-69	226.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,2PNPK@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	M	Mechanosensitive ion channel	VP2168	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel
k59_1119087_1	526222.Desal_3018	1.53e-167	483.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2WJ5B@28221|Deltaproteobacteria,2M7XR@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	PFAM Glutamyl glutaminyl-tRNA synthetase, class Ic, catalytic	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C
k59_766813_1	580332.Slit_1833	1.25e-62	202.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2VINX@28216|Betaproteobacteria,44WDD@713636|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM Alcohol dehydrogenase GroES domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_825773_2	1255043.TVNIR_3124	2.19e-84	258.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,1S2ET@1236|Gammaproteobacteria,1WWDD@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_1001705_1	713586.KB900536_gene1394	5.18e-62	198.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1WWVP@135613|Chromatiales	135613|Chromatiales	C	PFAM Cytochrome C1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
k59_649989_2	290399.Arth_4056	4.87e-49	167.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	degT	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
k59_239549_1	1340493.JNIF01000003_gene2325	5.47e-47	165.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	macB_1	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_825783_1	324602.Caur_0494	1.24e-09	60.8	COG0395@1|root,COG3833@1|root,COG0395@2|Bacteria,COG3833@2|Bacteria,2G8IJ@200795|Chloroflexi,3772H@32061|Chloroflexia	32061|Chloroflexia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K15772	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
k59_825783_2	511051.CSE_03860	4.76e-32	120.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	malF	-	-	ko:K02025,ko:K15770,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1,SBP_bac_8
k59_180321_1	1267005.KB911255_gene2980	5.89e-169	493.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2TQKJ@28211|Alphaproteobacteria,3N6GH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_5630_2	1227266.HMPREF1551_00348	7.1e-05	47.0	COG1219@1|root,COG1219@2|Bacteria,4NE1B@976|Bacteroidetes,1HXIP@117743|Flavobacteriia,1EQDH@1016|Capnocytophaga	976|Bacteroidetes	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_591393_1	247639.MGP2080_05090	1.02e-06	48.9	COG2930@1|root,COG2930@2|Bacteria,1RCYH@1224|Proteobacteria,1S41U@1236|Gammaproteobacteria,1J6CJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	s cog2930	CT2216	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_591393_2	1469607.KK073768_gene364	2.71e-28	112.0	COG0385@1|root,COG0385@2|Bacteria,1G2W8@1117|Cyanobacteria,1HMMK@1161|Nostocales	1117|Cyanobacteria	S	PFAM Sodium Bile acid symporter family	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
k59_766825_1	648757.Rvan_3500	1.53e-21	93.2	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQXI@28211|Alphaproteobacteria,3N61B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	5-aminolevulinic acid synthase	hemA	-	2.3.1.37	ko:K00643	ko00260,ko00860,ko01100,ko01110,map00260,map00860,map01100,map01110	-	R00830	RC00004,RC02815	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1298068_1	89187.ISM_10221	6.62e-28	106.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,2TRI2@28211|Alphaproteobacteria,46NR3@74030|Roseovarius	28211|Alphaproteobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_1298068_2	501479.ACNW01000103_gene609	5.38e-75	233.0	COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,2TS9D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG0524 Sugar kinases, ribokinase family	pfkB	-	2.7.1.20,2.7.1.4	ko:K00847,ko:K00856	ko00051,ko00230,ko00500,ko00520,ko01100,map00051,map00230,map00500,map00520,map01100	-	R00185,R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_945855_1	765912.Thimo_3047	1.44e-149	437.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1WXVV@135613|Chromatiales	135613|Chromatiales	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_358700_1	1260251.SPISAL_01225	3.01e-95	301.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1WX60@135613|Chromatiales	135613|Chromatiales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_825792_1	314278.NB231_04410	2.39e-14	77.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,1RPX5@1236|Gammaproteobacteria,1WX96@135613|Chromatiales	135613|Chromatiales	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1471847_1	717785.HYPMC_3864	1.34e-33	120.0	COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,2U960@28211|Alphaproteobacteria,3N8NC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory protein, arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
k59_650005_1	1479238.JQMZ01000001_gene2369	9.09e-75	237.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2TQU7@28211|Alphaproteobacteria,43X8G@69657|Hyphomonadaceae	28211|Alphaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_532618_1	1297742.A176_02164	1.54e-98	308.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,42MUY@68525|delta/epsilon subdivisions,2X6WF@28221|Deltaproteobacteria,2YWNJ@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase family M3	dcp	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_766835_1	391624.OIHEL45_08485	1.15e-13	71.6	COG0642@1|root,COG3452@1|root,COG0642@2|Bacteria,COG3452@2|Bacteria,1NXDJ@1224|Proteobacteria,2TWIH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	CHASE	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,PAS_7
k59_1354408_1	765911.Thivi_0738	2.85e-41	158.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1WXIK@135613|Chromatiales	135613|Chromatiales	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_121676_1	744980.TRICHSKD4_1117	7.56e-20	80.9	28X21@1|root,2ZJ0N@2|Bacteria,1P9K6@1224|Proteobacteria,2UVXP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1298086_1	335543.Sfum_0378	2.74e-37	137.0	COG0683@1|root,COG0683@2|Bacteria,1MX94@1224|Proteobacteria,42PYP@68525|delta/epsilon subdivisions,2WMA1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_1001726_1	768671.ThimaDRAFT_1427	2.77e-32	115.0	COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,1S3XF@1236|Gammaproteobacteria,1WY24@135613|Chromatiales	135613|Chromatiales	O	redox protein, regulator of disulfide bond formation	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
k59_298927_1	335543.Sfum_2807	1.71e-47	172.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N5C@68525|delta/epsilon subdivisions,2WM18@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
k59_767625_1	1033802.SSPSH_002508	7.47e-41	143.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355	Ubie_methyltran
k59_767625_2	497321.C664_13909	4.54e-52	168.0	COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,2VR9K@28216|Betaproteobacteria,2KWB0@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
k59_1473210_1	1288826.MSNKSG1_09868	1.67e-42	156.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,4668G@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_1473210_2	1265502.KB905946_gene1129	3.86e-42	147.0	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,2VRCS@28216|Betaproteobacteria,4AE1P@80864|Comamonadaceae	28216|Betaproteobacteria	S	Peptidase M15	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
k59_1473210_3	1260251.SPISAL_00725	6.27e-31	116.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,1WX0V@135613|Chromatiales	135613|Chromatiales	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_66562_1	1232437.KL662010_gene1646	2.3e-43	147.0	COG1553@1|root,COG1553@2|Bacteria,1NBVC@1224|Proteobacteria,42WGH@68525|delta/epsilon subdivisions,2WRSA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
k59_1589780_1	335543.Sfum_0828	1.77e-37	142.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WKB1@28221|Deltaproteobacteria,2MR2G@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_241280_1	765912.Thimo_0531	3.32e-136	417.0	COG1530@1|root,COG3266@1|root,COG1530@2|Bacteria,COG3266@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1WXN6@135613|Chromatiales	135613|Chromatiales	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_1649162_1	471853.Bcav_1922	1.61e-197	568.0	COG0187@1|root,COG0187@2|Bacteria,2GM1E@201174|Actinobacteria	201174|Actinobacteria	L	DNA topoisomerase (ATP-hydrolyzing)	gyrB2	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_1299489_2	1713.JOFV01000002_gene707	5.69e-33	125.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
k59_947267_1	1123279.ATUS01000002_gene101	1.89e-34	129.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,1J5AA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
k59_181336_1	196162.Noca_4469	1.21e-151	451.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria,4DSYG@85009|Propionibacteriales	201174|Actinobacteria	CP	Proton-conducting membrane transporter	-	-	-	ko:K12137	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
k59_592356_1	158500.BV97_05337	3.51e-89	277.0	COG1760@1|root,COG1760@2|Bacteria,1MUZN@1224|Proteobacteria,2TR3D@28211|Alphaproteobacteria,2K0NS@204457|Sphingomonadales	204457|Sphingomonadales	E	PFAM Serine dehydratase alpha chain	sdaA	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha,SDH_beta
k59_1589789_1	1121015.N789_08275	6.29e-67	227.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X34J@135614|Xanthomonadales	135614|Xanthomonadales	V	Efflux pump membrane transporter	mexF	-	-	ko:K19585	-	M00767	-	-	ko00000,ko00002,ko02000	2.A.6.2.47	-	-	ACR_tran
k59_1062410_1	1177181.T9A_01775	2.12e-40	144.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1XHN2@135619|Oceanospirillales	135619|Oceanospirillales	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_1062410_2	1122207.MUS1_06010	7.34e-07	47.8	COG2991@1|root,COG2991@2|Bacteria,1NI0R@1224|Proteobacteria,1SGJF@1236|Gammaproteobacteria,1XM95@135619|Oceanospirillales	135619|Oceanospirillales	S	protein conserved in bacteria	-	-	-	ko:K05952	-	-	-	-	ko00000	-	-	-	NqrM
k59_1119900_1	1713.JOFV01000001_gene2068	2.79e-86	277.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87,Zot
k59_826816_1	472759.Nhal_0269	2.88e-56	186.0	COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,1WWX2@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue	prmB	-	2.1.1.298	ko:K07320	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03009	-	-	-	MTS
k59_1355325_1	326297.Sama_1213	3.42e-07	51.6	COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria,1RZUI@1236|Gammaproteobacteria,2Q90S@267890|Shewanellaceae	1236|Gammaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
k59_360062_1	1134912.AJTV01000023_gene2878	8.03e-58	197.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria,36Y6U@31993|Methylocystaceae	28211|Alphaproteobacteria	MU	Outer membrane efflux protein	oprN	-	-	ko:K18300,ko:K19593	-	M00641,M00769	-	-	ko00000,ko00002,ko01504,ko02000	1.B.17,2.A.6.2.34	-	-	OEP
k59_1589793_1	644282.Deba_0792	4.69e-13	75.5	COG3829@1|root,COG5001@1|root,COG3829@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS_9,dCache_2
k59_651074_1	395493.BegalDRAFT_1564	1.13e-165	494.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,460EP@72273|Thiotrichales	72273|Thiotrichales	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_709698_1	1134474.O59_000509	1.09e-12	68.9	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1FGNR@10|Cellvibrio	1236|Gammaproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_298951_1	95619.PM1_0222995	4.51e-56	197.0	COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	P-type atpase	ccoI	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_826822_1	688270.Celal_3862	5.14e-83	266.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,4NF98@976|Bacteroidetes,1I0RT@117743|Flavobacteriia	976|Bacteroidetes	C	NADH flavin oxidoreductases, Old Yellow Enzyme family	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
k59_1649180_1	1122165.AUHS01000006_gene636	1.27e-12	67.8	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1JCZT@118969|Legionellales	118969|Legionellales	H	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_1649180_2	1123393.KB891316_gene1686	7.53e-52	181.0	COG0617@1|root,COG1371@1|root,COG0617@2|Bacteria,COG1371@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,1KRHG@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Archease,HD,PolyA_pol,PolyA_pol_RNAbd
k59_715139_1	1048829.XP_002789010.1	2.01e-19	78.6	2DZEY@1|root,2S6ZB@2759|Eukaryota,3A8VS@33154|Opisthokonta,3P6ME@4751|Fungi,3QYNF@4890|Ascomycota	4751|Fungi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_251228_1	396588.Tgr7_0573	3.14e-121	357.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria,1WX3F@135613|Chromatiales	135613|Chromatiales	E	Belongs to the peptidase M20A family. ArgE subfamily	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1834938_1	1000565.METUNv1_03870	1.08e-39	143.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2VJN0@28216|Betaproteobacteria,2KV6F@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
k59_1834938_2	1255043.TVNIR_2207	1.93e-11	64.3	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,1WVWN@135613|Chromatiales	135613|Chromatiales	M	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N
k59_367342_1	768671.ThimaDRAFT_0077	1.52e-56	194.0	COG0526@1|root,COG0526@2|Bacteria,1MWDE@1224|Proteobacteria,1S0NV@1236|Gammaproteobacteria,1WXDD@135613|Chromatiales	135613|Chromatiales	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
k59_367342_2	395494.Galf_0346	7.63e-16	74.7	COG0664@1|root,COG0664@2|Bacteria,1NBRS@1224|Proteobacteria,2WCFJ@28216|Betaproteobacteria,44VZA@713636|Nitrosomonadales	28216|Betaproteobacteria	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_832304_1	1283283.ATXA01000004_gene4289	4.79e-142	421.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sulfatase	atsB	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF1269,Sulfatase
k59_479940_1	159087.Daro_2602	2.1e-48	164.0	COG3221@1|root,COG3221@2|Bacteria,1QJET@1224|Proteobacteria,2VIVQ@28216|Betaproteobacteria,2KUCY@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
k59_895597_1	1267005.KB911257_gene1011	3.21e-103	306.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TUB8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_1834942_1	713587.THITH_15155	1.41e-64	217.0	COG3547@1|root,COG3547@2|Bacteria,1NN5F@1224|Proteobacteria	1224|Proteobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_17603_1	439235.Dalk_2211	3.41e-53	182.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,42NMY@68525|delta/epsilon subdivisions,2WJ8S@28221|Deltaproteobacteria,2MHS5@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the MurCDEF family	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_17604_1	765911.Thivi_4080	3.38e-137	396.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,1WWRX@135613|Chromatiales	135613|Chromatiales	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_128168_1	472759.Nhal_3354	3.9e-38	141.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1WXMI@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3,HlyD_D23
k59_832947_1	396588.Tgr7_1108	9.42e-27	101.0	COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria,1S73Y@1236|Gammaproteobacteria,1X24K@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_832947_2	543728.Vapar_5778	9.38e-82	249.0	COG0500@1|root,COG2226@2|Bacteria,1PG85@1224|Proteobacteria,2WC4M@28216|Betaproteobacteria,4AIUN@80864|Comamonadaceae	28216|Betaproteobacteria	H	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_1835754_1	765912.Thimo_2905	7.64e-84	253.0	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,1RMQ2@1236|Gammaproteobacteria,1WXB5@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
k59_421743_1	765420.OSCT_2139	2.6e-39	136.0	COG1136@1|root,COG1136@2|Bacteria,2G7XA@200795|Chloroflexi	200795|Chloroflexi	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_421743_2	765420.OSCT_2137	3.16e-20	89.0	COG4591@1|root,COG4591@2|Bacteria,2G85M@200795|Chloroflexi	200795|Chloroflexi	M	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_597722_1	395493.BegalDRAFT_3330	2.42e-34	123.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,1S4E6@1236|Gammaproteobacteria,460MP@72273|Thiotrichales	72273|Thiotrichales	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
k59_597722_2	999541.bgla_1g17730	1.03e-17	83.2	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2VHFD@28216|Betaproteobacteria,1JZSF@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_1071016_1	452637.Oter_0509	9.78e-22	99.8	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_896442_1	471853.Bcav_0973	5.09e-19	91.3	COG3583@1|root,COG3583@2|Bacteria,2I2GH@201174|Actinobacteria	201174|Actinobacteria	M	G5 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF348,G5,SLT
k59_18824_1	446469.Sked_36030	4.12e-55	181.0	COG0407@1|root,COG0407@2|Bacteria,2GMY6@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_1835784_1	1347392.CCEZ01000012_gene2519	1.51e-29	112.0	COG1762@1|root,COG1762@2|Bacteria,1VA2N@1239|Firmicutes,24N94@186801|Clostridia,36IDA@31979|Clostridiaceae	186801|Clostridia	G	phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	2.7.1.202	ko:K02768,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
k59_1360889_2	1353529.M899_1860	5.26e-28	112.0	2AMSR@1|root,31CP7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1246575_1	953739.SVEN_2926	2.86e-13	75.1	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_368179_1	96561.Dole_2294	7.43e-97	296.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,42N3G@68525|delta/epsilon subdivisions,2WIS9@28221|Deltaproteobacteria,2MI5A@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_597743_1	700598.Niako_0548	2.04e-72	221.0	COG2080@1|root,COG2080@2|Bacteria,4NMVV@976|Bacteroidetes,1IXEY@117747|Sphingobacteriia	976|Bacteroidetes	C	COGs COG2080 Aerobic-type carbon monoxide dehydrogenase small subunit CoxS CutS homologs	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_896453_1	1047013.AQSP01000114_gene705	3.77e-83	257.0	COG3385@1|root,COG3385@2|Bacteria,2NQNF@2323|unclassified Bacteria	2|Bacteria	L	Domain of unknown function (DUF4372)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_1420594_1	455436.DS989811_gene1831	1.69e-99	294.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,1RNH2@1236|Gammaproteobacteria,465ZA@72275|Alteromonadaceae	1236|Gammaproteobacteria	IQ	KR domain	phbB	-	1.1.1.100,1.1.1.36	ko:K00023,ko:K00059	ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212	M00083,M00373,M00572	R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00103,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1124841_1	768671.ThimaDRAFT_0705	2.96e-97	302.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_18841_1	714083.JH370377_gene671	1.64e-51	174.0	COG2984@1|root,COG2984@2|Bacteria,2GKNV@201174|Actinobacteria,4FNB4@85023|Microbacteriaceae	201174|Actinobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_1655379_1	42565.FP66_12035	3.1e-50	171.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,1RNZZ@1236|Gammaproteobacteria,1XIE0@135619|Oceanospirillales	135619|Oceanospirillales	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_1655379_2	765910.MARPU_07890	6.34e-05	44.7	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,1RMHS@1236|Gammaproteobacteria,1WY1C@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
k59_772406_1	1304865.JAGF01000001_gene692	4.45e-46	166.0	28PF4@1|root,2ZC6F@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1246579_1	547163.BN979_02605	3.01e-07	53.5	COG1176@1|root,COG1176@2|Bacteria,2GJ5G@201174|Actinobacteria,233PW@1762|Mycobacteriaceae	201174|Actinobacteria	P	ABC-type spermidine putrescine transport system, permease component I	potH	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
k59_1246579_2	1303692.SFUL_5599	1.06e-12	70.1	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	potA	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
k59_1071062_1	580332.Slit_1711	1.13e-99	315.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,44WAX@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.8.5.6	ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1595300_1	1249627.D779_0434	1.2e-32	121.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,1WXYW@135613|Chromatiales	135613|Chromatiales	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
k59_187526_1	398578.Daci_0917	1.06e-82	253.0	COG2071@1|root,COG2071@2|Bacteria,1MV8E@1224|Proteobacteria,2VMMI@28216|Betaproteobacteria,4AAN2@80864|Comamonadaceae	28216|Betaproteobacteria	S	Peptidase C26	-	-	4.1.3.27	ko:K01658,ko:K07010	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Peptidase_C26
k59_955435_1	1397278.AYMV01000057_gene2494	1.24e-05	55.1	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4FKBF@85023|Microbacteriaceae	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_252513_1	626887.J057_13601	4.17e-116	367.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464X3@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1071071_1	935839.JAGJ01000006_gene3428	1.27e-105	332.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,4F41Q@85017|Promicromonosporaceae	201174|Actinobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	fprE	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
k59_1307601_2	722419.PH505_fb00010	1.08e-97	306.0	COG3547@1|root,COG3547@2|Bacteria,1QYJU@1224|Proteobacteria,1RN0A@1236|Gammaproteobacteria,2Q3VH@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1481671_1	517722.AEUE01000026_gene2878	1.72e-12	70.5	COG3391@1|root,COG5184@1|root,COG3391@2|Bacteria,COG5184@2|Bacteria,1QWRQ@1224|Proteobacteria,2UEF5@28211|Alphaproteobacteria	1224|Proteobacteria	DZ	Protein of unknown function (DUF1573)	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Abhydrolase_3,Cadherin-like,Cadherin_3,TIG,VCBS
k59_368209_1	196164.23493383	2.8e-15	73.9	29WRJ@1|root,30ICM@2|Bacteria,2H09C@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1246610_1	1121878.AUGL01000021_gene2815	2.24e-108	330.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_1071075_1	930171.Asphe3_33260	3.61e-126	381.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,1W8AY@1268|Micrococcaceae	201174|Actinobacteria	S	Oxidoreductase molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
k59_1071075_2	935839.JAGJ01000004_gene2050	7.75e-80	244.0	29QBK@1|root,30BAT@2|Bacteria,2IH7J@201174|Actinobacteria,4F432@85017|Promicromonosporaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_896494_1	760568.Desku_1943	1.11e-18	85.1	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,260JY@186807|Peptococcaceae	186801|Clostridia	CI	Acetyl-CoA carboxylase, biotin carboxyl carrier protein	pycB	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_252554_1	316274.Haur_1467	8.98e-52	185.0	COG0577@1|root,COG0577@2|Bacteria,2G6IW@200795|Chloroflexi,374ZQ@32061|Chloroflexia	32061|Chloroflexia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1360931_1	1385515.N791_00815	1.3e-90	293.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1X51M@135614|Xanthomonadales	135614|Xanthomonadales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_480594_1	204669.Acid345_2010	2.45e-07	57.8	COG3026@1|root,COG3026@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	DUF4412,FtsX,LolA_like,MucB_RseB,MucB_RseB_C,zf-HC2
k59_1771464_1	1273538.G159_04930	3.05e-27	114.0	COG2909@1|root,COG2909@2|Bacteria,1UIMV@1239|Firmicutes,4HD7H@91061|Bacilli,26IIE@186818|Planococcaceae	91061|Bacilli	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
k59_74757_1	595460.RRSWK_05984	2.35e-132	390.0	COG3344@1|root,COG3344@2|Bacteria,2J0GH@203682|Planctomycetes	203682|Planctomycetes	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_896514_1	1049564.TevJSym_av00360	6.71e-68	227.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1J4UY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	general secretion pathway protein D	xcsD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_252567_1	335543.Sfum_2577	1.12e-76	241.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,42N2A@68525|delta/epsilon subdivisions,2WIP6@28221|Deltaproteobacteria,2MR42@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_1307646_1	1453501.JELR01000001_gene2006	5.96e-52	173.0	COG1075@1|root,COG1075@2|Bacteria,1N2W0@1224|Proteobacteria,1S2JW@1236|Gammaproteobacteria,46749@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,DUF676,Hydrolase_4
k59_1185693_1	886293.Sinac_4765	9.25e-37	147.0	COG3210@1|root,COG4733@1|root,COG3210@2|Bacteria,COG4733@2|Bacteria,2J50K@203682|Planctomycetes	203682|Planctomycetes	U	Pkd domain containing protein	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	-
k59_1246648_1	426114.THI_0137	2.61e-15	82.0	28IUD@1|root,2Z8T4@2|Bacteria,1QZHS@1224|Proteobacteria,2VK06@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Carboxysome shell peptide mid-region	-	-	-	-	-	-	-	-	-	-	-	-	CsoS2_M
k59_1655440_1	1198452.Jab_2c11020	5.75e-11	61.6	COG2846@1|root,COG2846@2|Bacteria,1QX13@1224|Proteobacteria,2WH3K@28216|Betaproteobacteria,477Y9@75682|Oxalobacteraceae	28216|Betaproteobacteria	D	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
k59_1655440_2	1028801.RG1141_CH34880	5.51e-08	54.7	COG0425@1|root,COG0425@2|Bacteria,1RB3E@1224|Proteobacteria,2U64X@28211|Alphaproteobacteria,4BEJC@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Uncharacterized conserved protein (DUF2249)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2249
k59_1595351_1	1196083.SALWKB12_1242	1.33e-49	171.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2VI0C@28216|Betaproteobacteria,2KQ16@206351|Neisseriales	206351|Neisseriales	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
k59_74773_1	1232410.KI421421_gene3487	2.19e-09	57.4	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2WV5U@28221|Deltaproteobacteria,43UX5@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
k59_74773_2	368407.Memar_1256	9.13e-30	108.0	COG0724@1|root,arCOG06896@2157|Archaea	2157|Archaea	S	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_252599_1	187272.Mlg_0438	1.98e-08	54.7	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1WX6G@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_304452_1	1121920.AUAU01000017_gene1198	2.12e-62	200.0	arCOG11509@1|root,31KIR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1771486_1	2340.JV46_24290	4.07e-112	332.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1J9VF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Hydrogenase formation hypA family	hypD	GO:0003674,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0036211,GO:0042165,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070025,GO:0071704,GO:1901564	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
k59_1771486_2	396588.Tgr7_1274	4.46e-116	340.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RN9Y@1236|Gammaproteobacteria,1WWGI@135613|Chromatiales	135613|Chromatiales	KO	TIGRFAM Hydrogenase accessory protein HypB	-	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
k59_1595355_1	999550.KI421507_gene1978	1.17e-185	525.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_29,HTH_32
k59_252619_1	765912.Thimo_2866	1.22e-85	281.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1536939_1	765913.ThidrDRAFT_1888	2.04e-63	211.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1WW15@135613|Chromatiales	135613|Chromatiales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_1713033_1	1380354.JIAN01000011_gene3187	7.79e-118	350.0	COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria,4F0U5@85016|Cellulomonadaceae	201174|Actinobacteria	J	PFAM RNA binding S1 domain protein	rpsA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_74793_1	290398.Csal_0874	4.7e-27	108.0	COG0847@1|root,COG0847@2|Bacteria,1P0GY@1224|Proteobacteria,1S6UR@1236|Gammaproteobacteria,1XJU3@135619|Oceanospirillales	135619|Oceanospirillales	L	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_252624_1	1047013.AQSP01000110_gene67	6.18e-92	280.0	COG0598@1|root,COG0598@2|Bacteria,2NPAW@2323|unclassified Bacteria	2|Bacteria	P	CorA-like Mg2+ transporter protein	corA	GO:0000041,GO:0000287,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015087,GO:0015095,GO:0015318,GO:0015693,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0050897,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070838,GO:0071840,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_1124905_1	1454010.JEOE01000017_gene1286	6.1e-163	476.0	COG0480@1|root,COG0480@2|Bacteria,2GKB3@201174|Actinobacteria,4F0RW@85016|Cellulomonadaceae	201174|Actinobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_252625_1	998674.ATTE01000001_gene486	2.08e-98	318.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,45ZSY@72273|Thiotrichales	72273|Thiotrichales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_1771498_1	1234364.AMSF01000053_gene1299	2.22e-50	173.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1X4GI@135614|Xanthomonadales	135614|Xanthomonadales	M	transferase	waaA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N
k59_842878_2	999550.KI421507_gene3213	3.41e-62	205.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2TRMY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_1604943_2	1380370.JIBA01000015_gene305	1.24e-70	221.0	29VND@1|root,30H5P@2|Bacteria,2ICBQ@201174|Actinobacteria,4FHGV@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1370853_2	1219080.VEZ01S_21_00350	6.94e-35	125.0	COG3043@1|root,COG3043@2|Bacteria,1RH0X@1224|Proteobacteria,1T0CQ@1236|Gammaproteobacteria,1XWYR@135623|Vibrionales	135623|Vibrionales	C	Electron transfer subunit of the periplasmic nitrate reductase complex NapAB	napB	-	-	ko:K02568	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798	RC02812	ko00000,ko00001,ko00002	-	-	-	NapB
k59_1781349_1	882378.RBRH_02178	1.88e-100	302.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VHZU@28216|Betaproteobacteria,1K0EZ@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_1085321_1	335543.Sfum_0851	1.48e-92	283.0	COG0618@1|root,COG0618@2|Bacteria,1N0JS@1224|Proteobacteria,42P1S@68525|delta/epsilon subdivisions,2WJV0@28221|Deltaproteobacteria,2MQTH@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Phosphoesterase RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
k59_1722948_1	1150864.MILUP08_43936	2.09e-48	165.0	2CAQZ@1|root,32RRU@2|Bacteria,2ICWM@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1722948_2	1150864.MILUP08_43935	3.88e-41	139.0	2ESDJ@1|root,33JY9@2|Bacteria,2IIMF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_725402_1	264462.Bd0142	1.08e-15	77.8	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,42NJT@68525|delta/epsilon subdivisions,2MUQI@213481|Bdellovibrionales,2WM7E@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	PFAM NAD-dependent epimerase dehydratase	dfrA	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	3Beta_HSD,Epimerase
k59_1494027_1	367299.JOEE01000007_gene162	4.51e-83	265.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,4FF11@85021|Intrasporangiaceae	201174|Actinobacteria	C	Catalyzes the formation of trans-2- enoyl-CoA from 2,4-dienoyl-CoA	fadH	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
k59_88642_1	768671.ThimaDRAFT_1450	4.09e-40	143.0	COG2854@1|root,COG2854@2|Bacteria,1NUHS@1224|Proteobacteria,1SN8R@1236|Gammaproteobacteria,1X0Q3@135613|Chromatiales	135613|Chromatiales	Q	MlaC protein	-	-	-	-	-	-	-	-	-	-	-	-	MlaC
k59_1430731_1	395493.BegalDRAFT_1784	1.54e-196	559.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,4601I@72273|Thiotrichales	72273|Thiotrichales	C	TIGRFAM cytochrome c oxidase accessory protein FixG	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
k59_1195688_2	1458357.BG58_03180	7.11e-43	144.0	2CI53@1|root,32S7C@2|Bacteria,1RE39@1224|Proteobacteria,2VV96@28216|Betaproteobacteria,1K8S1@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1849929_1	1454010.JEOE01000010_gene2785	1.05e-106	326.0	COG2844@1|root,COG2844@2|Bacteria,2GMKT@201174|Actinobacteria,4F0YZ@85016|Cellulomonadaceae	201174|Actinobacteria	O	metal-dependent phosphohydrolase HD sub domain	glnD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_969471_1	478801.Ksed_16880	4.68e-15	80.9	COG5340@1|root,COG5340@2|Bacteria,2GS2C@201174|Actinobacteria,1ZX6P@145357|Dermacoccaceae	201174|Actinobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
k59_490423_2	686340.Metal_3696	7.38e-35	122.0	2ED2F@1|root,336ZC@2|Bacteria,1N758@1224|Proteobacteria,1SE5R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
k59_490423_3	1240350.AMZE01000044_gene184	1.16e-36	132.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,1RNHI@1236|Gammaproteobacteria,1YWPK@136845|Pseudomonas putida group	1236|Gammaproteobacteria	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564	-	-	-	-	-	-	-	-	-	-	APH
k59_33722_1	649743.HMPREF0972_00096	0.000131	48.5	COG0454@1|root,COG0456@2|Bacteria,2IMS5@201174|Actinobacteria,4D862@85005|Actinomycetales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0044424,GO:0044464,GO:0048583,GO:0050789,GO:0065007,GO:0080134,GO:1902882	2.3.1.57	ko:K22441	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
k59_549006_1	909663.KI867150_gene1127	0.000232	42.7	COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,42SHG@68525|delta/epsilon subdivisions,2WP1D@28221|Deltaproteobacteria,2MQGS@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
k59_549006_2	1123288.SOV_1c07060	3.73e-77	234.0	COG2391@1|root,COG2391@2|Bacteria,1VJEX@1239|Firmicutes,4H6AR@909932|Negativicutes	909932|Negativicutes	S	Sulphur transport	-	-	-	-	-	-	-	-	-	-	-	-	Sulf_transp
k59_549006_3	882.DVU_1534	3.84e-05	44.3	COG2391@1|root,COG2391@2|Bacteria,1RDQK@1224|Proteobacteria,42RU6@68525|delta/epsilon subdivisions,2WNJT@28221|Deltaproteobacteria,2MBSU@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_88662_1	768671.ThimaDRAFT_2378	2.04e-20	86.7	COG3439@1|root,COG3439@2|Bacteria,1REDZ@1224|Proteobacteria,1RPW4@1236|Gammaproteobacteria,1WWHH@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_842903_1	396588.Tgr7_0356	2.04e-87	270.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWMG@135613|Chromatiales	135613|Chromatiales	L	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_969478_1	570967.JMLV01000001_gene2799	7.72e-91	277.0	2DG8R@1|root,2ZUYV@2|Bacteria,1R8VA@1224|Proteobacteria,2VGKJ@28211|Alphaproteobacteria,2JZ9B@204441|Rhodospirillales	204441|Rhodospirillales	H	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
k59_969478_2	1380391.JIAS01000011_gene5105	3.41e-17	79.7	COG1442@1|root,COG1442@2|Bacteria,1R5NA@1224|Proteobacteria,2U2U3@28211|Alphaproteobacteria,2JS2F@204441|Rhodospirillales	204441|Rhodospirillales	M	glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_197896_2	1195246.AGRI_05487	1.03e-146	447.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464AK@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_383239_1	685727.REQ_33830	2.67e-32	118.0	2D19V@1|root,32TA6@2|Bacteria,2IRPX@201174|Actinobacteria,4G2GB@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_383239_2	1156844.KB891831_gene4703	2.38e-16	82.4	28MY8@1|root,2ZB54@2|Bacteria,2GMYY@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_667557_1	1117943.SFHH103_03462	1.77e-128	384.0	COG3385@1|root,COG3385@2|Bacteria,1R821@1224|Proteobacteria,2VG9M@28211|Alphaproteobacteria,4BIX9@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_89694_1	1117318.PRUB_13801	3.79e-36	130.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,2Q154@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	F	COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase)	rimK	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
k59_1494872_1	1049564.TevJSym_ac00330	3.38e-80	248.0	2CGG3@1|root,33XQ6@2|Bacteria,1NWYE@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_491031_1	545276.KB898728_gene24	2.13e-94	286.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,1RMK2@1236|Gammaproteobacteria,1WX2M@135613|Chromatiales	135613|Chromatiales	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_491031_2	1205753.A989_05713	1.18e-07	52.4	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1X3KH@135614|Xanthomonadales	135614|Xanthomonadales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_549606_1	1123073.KB899241_gene3025	7.43e-20	81.3	COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,1SHHF@1236|Gammaproteobacteria,1X821@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	VL23_05015	-	-	-	-	-	-	-	-	-	-	-	zf-CHCC
k59_549606_2	225937.HP15_435	7.66e-68	232.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,464DC@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_197906_2	768671.ThimaDRAFT_1747	7.86e-21	94.4	COG0651@1|root,COG0651@2|Bacteria,1RBAF@1224|Proteobacteria,1S3IZ@1236|Gammaproteobacteria,1X24Y@135613|Chromatiales	135613|Chromatiales	CP	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_1260448_1	768671.ThimaDRAFT_2753	9.88e-66	207.0	COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,1RZQU@1236|Gammaproteobacteria,1WXG1@135613|Chromatiales	135613|Chromatiales	S	Belongs to the MtfA family	-	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90
k59_1260448_2	768671.ThimaDRAFT_2862	3.01e-08	54.3	COG3577@1|root,COG3577@2|Bacteria,1RAQK@1224|Proteobacteria,1S2GF@1236|Gammaproteobacteria,1WY1Z@135613|Chromatiales	135613|Chromatiales	S	gag-polyprotein putative aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,gag-asp_proteas
k59_843520_1	111781.Lepto7376_0734	7.62e-14	74.7	COG3271@1|root,COG3271@2|Bacteria,1G37M@1117|Cyanobacteria,1H999@1150|Oscillatoriales	1117|Cyanobacteria	S	Phytochelatin synthase	-	-	-	-	-	-	-	-	-	-	-	-	Phytochelatin
k59_1723593_1	1267005.KB911261_gene2205	9.68e-18	79.7	2991I@1|root,2ZW53@2|Bacteria,1P4XN@1224|Proteobacteria,2UZ03@28211|Alphaproteobacteria,3N94R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1134561_1	870187.Thini_0101	3.82e-157	454.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,45ZX7@72273|Thiotrichales	72273|Thiotrichales	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_1134561_2	204773.HEAR1381	2.61e-59	188.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,2VR60@28216|Betaproteobacteria,47412@75682|Oxalobacteraceae	28216|Betaproteobacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33,3.8.1.5	ko:K01563,ko:K11991	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670,R10223	RC00477,RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000,ko03016	-	-	-	Abhydrolase_1,MafB19-deam,TfoX_C
k59_1723597_1	349124.Hhal_1439	9.73e-125	372.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1WWJ8@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_383270_1	1122604.JONR01000016_gene4382	1.25e-24	103.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1X2YR@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_383270_2	713586.KB900536_gene2893	3.81e-50	161.0	COG0720@1|root,COG0720@2|Bacteria,1PNDM@1224|Proteobacteria,1S7ZW@1236|Gammaproteobacteria,1WZ30@135613|Chromatiales	135613|Chromatiales	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
k59_608303_1	648885.KB316283_gene3668	8.61e-29	114.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2TRAA@28211|Alphaproteobacteria,1JR33@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	integrase domain protein SAM domain protein	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_383274_1	519989.ECTPHS_01924	1.1e-91	293.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1134569_2	882378.RBRH_02108	1.21e-59	198.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VI5U@28216|Betaproteobacteria,1JZWP@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
k59_1016215_1	1304885.AUEY01000003_gene492	3.76e-133	390.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,42MB8@68525|delta/epsilon subdivisions,2WIW7@28221|Deltaproteobacteria,2MID8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM cytochrome bd ubiquinol oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_1322779_1	1163409.UUA_02186	6.39e-73	238.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1X4EX@135614|Xanthomonadales	135614|Xanthomonadales	J	elongation factor G	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_608308_1	1121405.dsmv_1427	2.25e-75	234.0	COG2836@1|root,COG2836@2|Bacteria,1PJER@1224|Proteobacteria,43EBU@68525|delta/epsilon subdivisions,2X2D4@28221|Deltaproteobacteria,2MMFS@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
k59_89740_1	96561.Dole_2495	5.93e-98	298.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,42M48@68525|delta/epsilon subdivisions,2WISV@28221|Deltaproteobacteria,2MIBH@213118|Desulfobacterales	28221|Deltaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_911561_1	1249627.D779_0508	8.09e-145	417.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RMKD@1236|Gammaproteobacteria,1WXNH@135613|Chromatiales	135613|Chromatiales	P	PFAM Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_1431367_1	933262.AXAM01000029_gene2745	5.45e-103	307.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,42QE5@68525|delta/epsilon subdivisions,2WM8R@28221|Deltaproteobacteria,2MHVT@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
k59_491054_1	1123401.JHYQ01000037_gene1648	8.39e-67	216.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RYHN@1236|Gammaproteobacteria,460J6@72273|Thiotrichales	72273|Thiotrichales	P	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS_2
k59_491054_2	1121033.AUCF01000010_gene4454	7.55e-86	262.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria,2JQTF@204441|Rhodospirillales	204441|Rhodospirillales	Q	ATPases associated with a variety of cellular activities	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_1547390_1	1121035.AUCH01000002_gene1566	1.71e-06	46.6	COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,2VUM7@28216|Betaproteobacteria,2KWK7@206389|Rhodocyclales	206389|Rhodocyclales	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
k59_1547390_2	913325.N799_10530	2.21e-25	97.4	COG0271@1|root,COG0271@2|Bacteria,1QCDM@1224|Proteobacteria,1RTFD@1236|Gammaproteobacteria,1X7ES@135614|Xanthomonadales	135614|Xanthomonadales	T	Belongs to the BolA IbaG family	-	-	-	ko:K05527	-	-	-	-	ko00000,ko03000	-	-	-	BolA
k59_1547390_3	348824.LPU83_3788	6.96e-41	150.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2TVQD@28211|Alphaproteobacteria,4B95A@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	peptidyl-prolyl isomerase	ppiC	-	5.2.1.8	ko:K01802,ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3
k59_549635_1	1120960.ATXG01000009_gene142	2e-93	284.0	COG0686@1|root,COG0686@2|Bacteria,2GKMN@201174|Actinobacteria,4FQYJ@85023|Microbacteriaceae	201174|Actinobacteria	E	Alanine dehydrogenase/PNT, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_1322789_1	857087.Metme_0874	2.34e-27	117.0	COG3291@1|root,COG3291@2|Bacteria,1RGWM@1224|Proteobacteria,1THXR@1236|Gammaproteobacteria,1XFZT@135618|Methylococcales	135618|Methylococcales	S	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD
k59_608315_1	1049564.TevJSym_bk00230	6.57e-121	363.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Alpha amylase catalytic	ams	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_1781931_1	1299327.I546_3965	1.83e-114	354.0	COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria,2337J@1762|Mycobacteriaceae	201174|Actinobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_1781931_2	1126627.BAWE01000005_gene6286	6.7e-14	71.6	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,2TU2E@28211|Alphaproteobacteria,3JRH2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	aldehyde-lyase activity	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
k59_1851043_1	1100721.ALKO01000033_gene245	1.35e-11	69.7	COG2114@1|root,COG2199@1|root,COG2114@2|Bacteria,COG3706@2|Bacteria,1R0WG@1224|Proteobacteria,2WI7R@28216|Betaproteobacteria,4AK4P@80864|Comamonadaceae	28216|Betaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_268585_1	1384056.N787_06735	3.75e-97	288.0	COG2820@1|root,COG2820@2|Bacteria,1QVR4@1224|Proteobacteria,1T2HJ@1236|Gammaproteobacteria,1X3C6@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile	-	-	3.2.2.4	ko:K01241	ko00230,map00230	-	R00182	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
k59_1431377_1	926569.ANT_29200	2.02e-58	201.0	COG4412@1|root,COG4412@2|Bacteria,2G622@200795|Chloroflexi	200795|Chloroflexi	S	Immune inhibitor A peptidase M6	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6
k59_1666231_1	768671.ThimaDRAFT_0997	8.8e-183	525.0	COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,1WXBQ@135613|Chromatiales	135613|Chromatiales	O	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_911590_2	710111.FraQA3DRAFT_1161	2.33e-157	450.0	COG0596@1|root,COG0596@2|Bacteria,2GK79@201174|Actinobacteria,4ETSU@85013|Frankiales	201174|Actinobacteria	S	Epoxide hydrolase	-	-	3.3.2.9	ko:K01253	ko00980,ko04976,ko05204,map00980,map04976,map05204	-	R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443	RC01447,RC01728,RC01764,RC02528	ko00000,ko00001,ko01000,ko01002	-	-	-	EHN
k59_1371485_1	247639.MGP2080_04995	1.19e-68	219.0	COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,1S0GN@1236|Gammaproteobacteria,1J71W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_726077_1	768671.ThimaDRAFT_4484	5.33e-96	288.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1Q7PK@1224|Proteobacteria,1RSF0@1236|Gammaproteobacteria,1WWA3@135613|Chromatiales	135613|Chromatiales	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_29,HTH_33
k59_1260512_1	545264.KB898746_gene896	3.46e-92	290.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,1WWBM@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
k59_549656_1	512565.AMIS_34610	5.64e-96	284.0	COG0110@1|root,COG0110@2|Bacteria,2GNUB@201174|Actinobacteria,4DI4Q@85008|Micromonosporales	201174|Actinobacteria	S	Maltose acetyltransferase	maa	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2,Mac
k59_1431390_1	225849.swp_0931	3.18e-145	425.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,1RQK5@1236|Gammaproteobacteria,2QAED@267890|Shewanellaceae	1236|Gammaproteobacteria	C	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_1086258_1	398525.KB900701_gene3304	3.88e-36	135.0	COG0598@1|root,COG0598@2|Bacteria,1MWMP@1224|Proteobacteria,2TQQD@28211|Alphaproteobacteria,3JTS3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	CorA-like Mg2+ transporter protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_35032_1	338963.Pcar_1641	6.46e-54	177.0	COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2WIN0@28221|Deltaproteobacteria,43SEB@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
k59_1864440_2	1229172.JQFA01000002_gene2577	1.19e-21	94.0	COG3367@1|root,COG3367@2|Bacteria,1GBZ5@1117|Cyanobacteria	1117|Cyanobacteria	S	COGs COG3367 conserved	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_146939_1	1267005.KB911257_gene1029	1.98e-13	70.9	COG0507@1|root,COG0507@2|Bacteria,1QCFP@1224|Proteobacteria,2V700@28211|Alphaproteobacteria,3N8NH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Helicase	-	-	-	-	-	-	-	-	-	-	-	-	Herpes_Helicase,PIF1
k59_146939_2	1038859.AXAU01000016_gene6868	1.41e-23	91.7	2DR1J@1|root,339SA@2|Bacteria,1NI5R@1224|Proteobacteria,2UM1E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Peptidase propeptide and YPEB domain	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_2
k59_733794_1	1265505.ATUG01000002_gene1832	5.89e-114	336.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42NHU@68525|delta/epsilon subdivisions,2WIZ1@28221|Deltaproteobacteria,2MIQ6@213118|Desulfobacterales	28221|Deltaproteobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.99.32	ko:K16173	ko00362,ko01120,map00362,map01120	-	R05579	RC00052	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1503244_1	1385515.N791_03625	3.18e-139	404.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1X4F6@135614|Xanthomonadales	135614|Xanthomonadales	NU	twitching motility protein	pilU	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_787618_1	1123392.AQWL01000004_gene2564	8.55e-15	73.2	COG1230@1|root,COG1230@2|Bacteria,1QUZ5@1224|Proteobacteria,2WGMK@28216|Betaproteobacteria,1KRTJ@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
k59_205527_1	631362.Thi970DRAFT_02000	1.79e-86	266.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RZFF@1236|Gammaproteobacteria,1WZJI@135613|Chromatiales	135613|Chromatiales	C	cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG
k59_924865_1	1410674.JNKU01000008_gene1277	4.62e-23	95.5	COG0406@1|root,COG0406@2|Bacteria,1TQWQ@1239|Firmicutes,4HF2N@91061|Bacilli,3F524@33958|Lactobacillaceae	91061|Bacilli	G	Phosphoglycerate mutase family	gpmB	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_278501_1	1123360.thalar_00143	1.65e-38	137.0	COG0454@1|root,COG0456@2|Bacteria,1QVPG@1224|Proteobacteria,2TWJF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3
k59_205531_1	479431.Namu_4791	5.92e-57	178.0	COG1695@1|root,COG1695@2|Bacteria,2IQSE@201174|Actinobacteria,4EW7Q@85013|Frankiales	201174|Actinobacteria	K	PFAM transcriptional regulator PadR family protein	ywzG	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_733821_1	1283283.ATXA01000004_gene4417	2.31e-67	216.0	COG2873@1|root,COG2873@2|Bacteria,2I2EB@201174|Actinobacteria,4ES02@85013|Frankiales	201174|Actinobacteria	E	PFAM Cys Met metabolism	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1022515_1	522306.CAP2UW1_2844	1.01e-112	342.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHSM@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family	rosB	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
k59_1864492_1	391615.ABSJ01000042_gene2272	9.6e-119	351.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1J8WH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	iYL1228.KPN_02462	AdoHcyase,AdoHcyase_NAD
k59_146967_1	314345.SPV1_05607	2.45e-124	377.0	COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria	1224|Proteobacteria	M	Glycosyl transferase group 1	mfpsA	GO:0003674,GO:0003824,GO:0005975,GO:0005984,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0034637,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0071704,GO:1901576	2.4.1.14,2.4.1.246	ko:K00696,ko:K13058	ko00500,ko01100,map00500,map01100	-	R00766,R08947	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth
k59_1503264_1	331678.Cphamn1_0816	3.44e-208	590.0	COG1236@1|root,COG1236@2|Bacteria,1FER3@1090|Chlorobi	1090|Chlorobi	J	PFAM beta-lactamase domain protein	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
k59_102946_1	880072.Desac_2873	2.61e-51	174.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,42NBY@68525|delta/epsilon subdivisions,2WJV2@28221|Deltaproteobacteria,2MQVT@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
k59_102946_2	335543.Sfum_0109	2.92e-15	75.1	COG2454@1|root,COG2454@2|Bacteria,1N6TV@1224|Proteobacteria,42VER@68525|delta/epsilon subdivisions,2WRI3@28221|Deltaproteobacteria,2MS7Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF434)	-	-	-	-	-	-	-	-	-	-	-	-	DUF434
k59_1612901_1	743718.Isova_2505	3.4e-76	244.0	COG1207@1|root,COG1207@2|Bacteria,2GJS1@201174|Actinobacteria,4F440@85017|Promicromonosporaceae	201174|Actinobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030260,GO:0035635,GO:0040007,GO:0043167,GO:0043169,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
k59_1731214_1	243231.GSU3245	5.29e-55	192.0	COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,42Q4K@68525|delta/epsilon subdivisions,2WKQ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA polymerase type-B family	polB	-	2.7.7.7	ko:K02336	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
k59_45556_1	690850.Desaf_1866	1.41e-57	199.0	COG1148@1|root,COG1148@2|Bacteria,1QUMN@1224|Proteobacteria,43BMA@68525|delta/epsilon subdivisions,2X6ZG@28221|Deltaproteobacteria,2M898@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
k59_1022520_1	335543.Sfum_4014	6.57e-126	370.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,42M6R@68525|delta/epsilon subdivisions,2WJDQ@28221|Deltaproteobacteria,2MR11@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	TIGRFAM hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	iAF987.Gmet_0117	HypD
k59_615832_1	977880.RALTA_A2390	7.25e-75	235.0	COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,2VJAD@28216|Betaproteobacteria,1K19M@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
k59_675269_1	1416759.AYMR01000027_gene1405	5.11e-144	413.0	COG0596@1|root,COG0596@2|Bacteria,2GNBX@201174|Actinobacteria,4FMA9@85023|Microbacteriaceae	201174|Actinobacteria	S	Belongs to the peptidase S33 family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
k59_850945_1	1217718.ALOU01000043_gene4034	1.12e-90	280.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2VIFW@28216|Betaproteobacteria,1KI03@119060|Burkholderiaceae	28216|Betaproteobacteria	P	C-terminal region of aryl-sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,Sulfatase_C
k59_1022530_1	367299.JOEE01000001_gene2111	2.53e-30	114.0	COG2068@1|root,COG2068@2|Bacteria,2GK5R@201174|Actinobacteria,4FH6R@85021|Intrasporangiaceae	201174|Actinobacteria	S	MobA-like NTP transferase domain	nboR	-	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120	-	R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
k59_1022530_2	710696.Intca_0590	9.63e-37	127.0	COG2149@1|root,COG2149@2|Bacteria,2GQU9@201174|Actinobacteria,4FHFI@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF202)	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
k59_924942_1	207954.MED92_17645	6.56e-31	112.0	COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,1SDIM@1236|Gammaproteobacteria,1XKKN@135619|Oceanospirillales	135619|Oceanospirillales	J	RNA-binding protein containing KH domain, possibly ribosomal protein	yhbY	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
k59_924942_2	1150469.RSPPHO_01636	9.67e-22	93.6	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,2JQKY@204441|Rhodospirillales	204441|Rhodospirillales	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
k59_1336212_1	713586.KB900536_gene1022	7.18e-145	421.0	COG5557@1|root,COG5557@2|Bacteria,1MXP7@1224|Proteobacteria,1RS7Z@1236|Gammaproteobacteria,1WX2A@135613|Chromatiales	135613|Chromatiales	C	PFAM Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_1336212_2	1121033.AUCF01000010_gene4539	3.62e-14	71.2	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,2U4JG@28211|Alphaproteobacteria,2JVHK@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	-	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,GATase_3
k59_787659_1	768671.ThimaDRAFT_3408	1.58e-97	304.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1WWM9@135613|Chromatiales	135613|Chromatiales	O	Cytochrome c-type biogenesis protein	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_615842_1	1267005.KB911257_gene638	3.08e-58	186.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2TSS5@28211|Alphaproteobacteria,3N6Q6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_615842_2	644076.SCH4B_0654	2.42e-16	72.8	COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,2UJJF@28211|Alphaproteobacteria,4NCVJ@97050|Ruegeria	28211|Alphaproteobacteria	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	yacG	-	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
k59_615843_1	313612.L8106_19913	6.01e-49	171.0	COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,1G16R@1117|Cyanobacteria,1H85V@1150|Oscillatoriales	1117|Cyanobacteria	C	belongs to the CobB CobQ family	pta	-	2.3.1.8	ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,DRTGG,PTA_PTB
k59_615843_2	1476876.JOJO01000001_gene8059	2.12e-20	91.7	COG0282@1|root,COG0282@2|Bacteria,2GJAW@201174|Actinobacteria	201174|Actinobacteria	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0409	Acetate_kinase
k59_1864544_1	1049564.TevJSym_ao00720	5.59e-95	296.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1J4EU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604	PBP_dimer,Transpeptidase
k59_733861_1	485915.Dret_0551	4.69e-80	251.0	COG3464@1|root,COG3464@2|Bacteria,1R4DH@1224|Proteobacteria,43AQ4@68525|delta/epsilon subdivisions,2X63W@28221|Deltaproteobacteria,2MGXP@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM transposase IS204 IS1001 IS1096 IS1165 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,zf-ISL3
k59_1378847_1	1049564.TevJSym_am00190	5.5e-22	93.2	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,1J5GD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	iSBO_1134.SBO_0282,ic_1306.c0493	F420_oxidored,P5CR_dimer
k59_1378847_2	1121013.P873_13245	2.88e-25	103.0	COG2805@1|root,COG5008@1|root,COG2805@2|Bacteria,COG5008@2|Bacteria,1MU3J@1224|Proteobacteria,1T393@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	Type II/IV secretion system protein	-	-	-	ko:K12203	-	-	-	-	ko00000,ko02044	3.A.7.10.1,3.A.7.9.1	-	-	T2SSE
k59_1141086_1	472759.Nhal_1652	9.22e-25	107.0	COG1538@1|root,COG1538@2|Bacteria,1NEZC@1224|Proteobacteria,1S1F9@1236|Gammaproteobacteria,1X1BJ@135613|Chromatiales	135613|Chromatiales	MU	PFAM Outer membrane efflux protein	-	-	-	ko:K15725	-	-	-	-	ko00000,ko02000	1.B.17.2.2	-	-	OEP
k59_1336228_1	1049564.TevJSym_ak00710	1.55e-67	220.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1J6MY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_1438902_1	631362.Thi970DRAFT_04697	3.73e-90	296.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales	135613|Chromatiales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1554744_1	1123070.KB899251_gene718	5.66e-33	125.0	COG0202@1|root,COG0202@2|Bacteria,46S52@74201|Verrucomicrobia,2ITN6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_984996_1	1078020.KEK_13178	1.04e-23	104.0	COG1053@1|root,COG1053@2|Bacteria,2GIXG@201174|Actinobacteria,233J3@1762|Mycobacteriaceae	201174|Actinobacteria	C	Succinate dehydrogenase fumarate reductase flavoprotein subunit	-	-	1.3.99.4	ko:K05898	ko00984,ko01100,ko01120,map00984,map01100,map01120	-	R09884	RC00991	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2
k59_675858_2	1122212.AULO01000010_gene271	2.51e-05	47.8	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,1S612@1236|Gammaproteobacteria,1XJPQ@135619|Oceanospirillales	135619|Oceanospirillales	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
k59_147560_1	1386089.N865_07540	0.0	1081.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4FIMQ@85021|Intrasporangiaceae	201174|Actinobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_557761_1	713586.KB900536_gene2596	1.52e-93	287.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1WWJH@135613|Chromatiales	135613|Chromatiales	E	peptidase M24B, X-Pro dipeptidase aminopeptidase	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_1095194_1	1255043.TVNIR_0680	4.01e-105	313.0	COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,1RMIY@1236|Gammaproteobacteria,1WWR3@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
k59_1674435_1	1207075.PputUW4_02305	6.98e-65	210.0	28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1329
k59_1731803_1	717785.HYPMC_2063	1.53e-104	317.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2TQU9@28211|Alphaproteobacteria,3N689@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_1439497_1	396588.Tgr7_1255	2.8e-130	376.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1WW2U@135613|Chromatiales	135613|Chromatiales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_279164_1	933262.AXAM01000022_gene3242	3.35e-94	285.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,42N69@68525|delta/epsilon subdivisions,2WIUJ@28221|Deltaproteobacteria,2MJ4T@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
k59_851563_1	1283300.ATXB01000001_gene1977	2.66e-100	312.0	COG1132@1|root,COG1132@2|Bacteria,1MVJD@1224|Proteobacteria,1RNRM@1236|Gammaproteobacteria,1XGEK@135618|Methylococcales	135618|Methylococcales	V	ABC transporter transmembrane region	-	-	-	ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1	-	-	ABC_membrane,ABC_tran
k59_734494_1	471856.Jden_2425	4.02e-23	93.2	COG0461@1|root,COG0461@2|Bacteria,2GKUQ@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
k59_734494_2	1304865.JAGF01000001_gene986	1.41e-98	295.0	COG0300@1|root,COG0300@2|Bacteria,2GKJE@201174|Actinobacteria,4F115@85016|Cellulomonadaceae	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
k59_1095205_1	631362.Thi970DRAFT_03912	1.92e-60	200.0	COG0438@1|root,COG0438@2|Bacteria,1QF9A@1224|Proteobacteria,1RMDT@1236|Gammaproteobacteria,1WW1R@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_323428_1	1122604.JONR01000069_gene4619	1.21e-23	97.4	2BAAU@1|root,323R2@2|Bacteria,1MYZ6@1224|Proteobacteria,1S7ER@1236|Gammaproteobacteria,1X9MC@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_323428_2	1415780.JPOG01000001_gene2196	9.92e-46	156.0	COG3714@1|root,COG3714@2|Bacteria,1QE44@1224|Proteobacteria,1TAFY@1236|Gammaproteobacteria,1X8EB@135614|Xanthomonadales	135614|Xanthomonadales	S	YhhN family	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
k59_499220_1	1265313.HRUBRA_01469	5.25e-75	236.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1S4FT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Bacterial lipid A biosynthesis acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Lip_A_acyltrans
k59_499220_2	1265313.HRUBRA_01470	1.4e-98	291.0	COG3000@1|root,COG3000@2|Bacteria,1RA8D@1224|Proteobacteria,1T0EN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_1095210_1	880072.Desac_1395	3.87e-88	269.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,2MQ9B@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_1613506_1	1380354.JIAN01000005_gene2756	3.37e-85	283.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria,4F266@85016|Cellulomonadaceae	201174|Actinobacteria	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
k59_103970_1	411684.HPDFL43_20697	0.000161	45.8	COG0398@1|root,COG0398@2|Bacteria,1MVF3@1224|Proteobacteria,2U6DE@28211|Alphaproteobacteria,43JTK@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	SNARE associated Golgi protein	merA_1	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_925938_1	1122947.FR7_4081	3.77e-57	191.0	COG3875@1|root,COG3875@2|Bacteria,1TUCQ@1239|Firmicutes,4H66I@909932|Negativicutes	909932|Negativicutes	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
k59_1503903_1	360094.PXO_06103	3.88e-83	260.0	COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,1RQQA@1236|Gammaproteobacteria,1X5JB@135614|Xanthomonadales	1236|Gammaproteobacteria	L	Helix-turn-helix domain of transposase family ISL3	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_734509_1	1125863.JAFN01000001_gene1617	1.49e-56	195.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WK23@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
k59_557791_1	519989.ECTPHS_12913	1.19e-95	287.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1WWPW@135613|Chromatiales	135613|Chromatiales	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_1095223_1	630626.EBL_c30040	1.92e-07	51.2	COG3926@1|root,COG3926@2|Bacteria,1MVXW@1224|Proteobacteria,1RRB6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	secretion activating protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_108,PG_binding_3
k59_1095223_2	665942.HMPREF1022_01523	1.28e-36	130.0	2E16H@1|root,32WMB@2|Bacteria,1N6EU@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1503908_1	1415779.JOMH01000001_gene120	8.03e-62	200.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1X4A7@135614|Xanthomonadales	135614|Xanthomonadales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
k59_1555315_1	323261.Noc_2184	1.97e-38	135.0	COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,1SYJC@1236|Gammaproteobacteria,1WW83@135613|Chromatiales	135613|Chromatiales	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1204399_1	1297742.A176_05021	2.21e-05	52.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,42MBA@68525|delta/epsilon subdivisions,2WKX9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_1023028_1	2340.JV46_23290	4.01e-60	190.0	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,1S40Q@1236|Gammaproteobacteria,1J5QA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_1613517_1	696747.NIES39_D06770	9.38e-07	55.8	COG2931@1|root,COG2931@2|Bacteria,1G02E@1117|Cyanobacteria,1H9TQ@1150|Oscillatoriales	1117|Cyanobacteria	Q	Hemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HemolysinCabind,SBBP
k59_925954_2	653045.Strvi_5629	1.21e-40	139.0	COG3877@1|root,COG3877@2|Bacteria,2IJTS@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
k59_557793_1	396588.Tgr7_1994	3.5e-62	217.0	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,1RNP1@1236|Gammaproteobacteria,1WWFF@135613|Chromatiales	135613|Chromatiales	V	ABC-type transport system, involved in lipoprotein release, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_397536_1	589865.DaAHT2_1873	1.39e-51	172.0	COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,42NE6@68525|delta/epsilon subdivisions,2WJ92@28221|Deltaproteobacteria,2MJ1B@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_2
k59_1210325_1	314278.NB231_14478	1.26e-83	249.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,1S45S@1236|Gammaproteobacteria,1WYJA@135613|Chromatiales	135613|Chromatiales	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
k59_1210325_2	1255043.TVNIR_3060	8.92e-41	144.0	COG1352@1|root,COG1352@2|Bacteria,1RDBE@1224|Proteobacteria,1SJIV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NT	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR
k59_935214_1	107636.JQNK01000009_gene2546	2.05e-05	51.6	COG3637@1|root,COG3637@2|Bacteria,1R4WV@1224|Proteobacteria,2U0V2@28211|Alphaproteobacteria,36ZXH@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Outer membrane protein beta-barrel domain	ropB	-	-	ko:K16079	-	-	-	-	ko00000,ko02000	1.B.4.2.1	-	-	OMP_b-brl
k59_1385840_1	908340.HMPREF9406_1292	1.81e-16	84.0	COG2199@1|root,COG3706@2|Bacteria,1VADD@1239|Firmicutes,25E7Q@186801|Clostridia,36UW7@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	2.7.7.65	ko:K21022	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	GAF,GAF_2,GAF_3,GGDEF,PAS_9
k59_446763_1	471853.Bcav_1076	9.49e-57	180.0	COG0782@1|root,COG0782@2|Bacteria,2GNZV@201174|Actinobacteria	201174|Actinobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0071944	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_113552_1	497321.C664_06253	2.36e-98	295.0	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VX1Q@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_1738047_1	794903.OPIT5_02585	1.47e-70	233.0	COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,46U8H@74201|Verrucomicrobia,3K8WM@414999|Opitutae	414999|Opitutae	C	Glucose sorbosone dehydrogenase	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,GSDH
k59_1738047_2	1089553.Tph_c22610	1.89e-47	163.0	COG0731@1|root,COG0731@2|Bacteria,1TSYW@1239|Firmicutes,24CEP@186801|Clostridia,42ID6@68295|Thermoanaerobacterales	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
k59_563972_1	1267005.KB911257_gene1077	1.25e-118	380.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,3N63N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Alpha-2-Macroglobulin	MA20_30110	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,PAN_1,Thiol-ester_cl
k59_1510985_1	1415778.JQMM01000001_gene2119	2.18e-79	250.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1J640@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Virulence factor BrkB	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
k59_113564_1	177437.HRM2_11030	3.48e-64	218.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,42MKN@68525|delta/epsilon subdivisions,2WJV6@28221|Deltaproteobacteria,2MHUC@213118|Desulfobacterales	28221|Deltaproteobacteria	U	type II and III secretion system protein	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_1445567_1	384765.SIAM614_02581	4.72e-139	411.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1620380_1	519989.ECTPHS_01174	4.3e-86	278.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
k59_330458_1	75379.Tint_0129	3.73e-136	409.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJJW@28216|Betaproteobacteria,1KKYF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	von Willebrand factor (vWF) type A domain	cbbO	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
k59_623240_1	525897.Dbac_2941	6.84e-49	173.0	COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,42M2C@68525|delta/epsilon subdivisions,2WIVE@28221|Deltaproteobacteria,2M8MU@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
k59_1277401_1	1158756.AQXQ01000010_gene2231	4.37e-77	240.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,1RNRI@1236|Gammaproteobacteria,1WYA5@135613|Chromatiales	135613|Chromatiales	I	Squalene phytoene synthase	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
k59_1277401_2	216142.LT40_01250	0.000164	45.1	COG1028@1|root,COG1028@2|Bacteria,1MXVZ@1224|Proteobacteria,1RRUK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)	yxbG	-	1.1.1.304,1.1.1.76	ko:K18009	ko00650,map00650	-	R03707,R09078,R10505	RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
k59_1147735_1	749414.SBI_06807	2.56e-10	66.2	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria	201174|Actinobacteria	F	Drug exporters of the RND superfamily	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
k59_447421_1	765912.Thimo_0056	1.06e-23	97.1	COG3165@1|root,COG3165@2|Bacteria,1R1CM@1224|Proteobacteria,1S1SM@1236|Gammaproteobacteria,1WWJP@135613|Chromatiales	135613|Chromatiales	S	Sterol-binding domain protein	-	-	-	ko:K03690	-	-	-	-	ko00000	-	-	-	SCP2
k59_447421_2	1384056.N787_02890	1.91e-15	77.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1X3E2@135614|Xanthomonadales	135614|Xanthomonadales	S	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
k59_114482_1	1249627.D779_3927	5.16e-63	216.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWJ6@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1029952_2	237368.SCABRO_03845	9.39e-20	84.3	2EH29@1|root,33AU8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_793626_2	68170.KL590500_gene3692	1.96e-65	207.0	28P5T@1|root,2ZC0N@2|Bacteria,2GP34@201174|Actinobacteria,4E17R@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_793626_3	1245475.ANAE01000087_gene1154	2.45e-14	71.2	2CIG4@1|root,33C84@2|Bacteria,2HUTU@201174|Actinobacteria,4EKX9@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1876099_1	1056512.D515_03771	3.15e-44	160.0	COG0564@1|root,COG0564@2|Bacteria,1MVJ5@1224|Proteobacteria,1RN61@1236|Gammaproteobacteria,1XSMM@135623|Vibrionales	135623|Vibrionales	J	COG0564 Pseudouridylate synthases, 23S RNA-specific	-	-	5.4.99.28,5.4.99.29	ko:K06177	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
k59_1511597_1	1247963.JPHU01000002_gene2492	5.58e-47	163.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,2TST5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0530 Ca2 Na antiporter	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_682986_1	251229.Chro_4812	3.1e-97	315.0	COG2372@1|root,COG2372@2|Bacteria	2|Bacteria	C	response to copper ion	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082,SASA,SLH
k59_288918_1	85643.Tmz1t_2792	1.97e-09	62.8	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,2KUIC@206389|Rhodocyclales	206389|Rhodocyclales	S	Peptidase M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_16,TPR_19
k59_1210964_1	1386089.N865_07520	4.44e-92	286.0	28HJF@1|root,2Z7UK@2|Bacteria,2ICK7@201174|Actinobacteria,4FIJ9@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1681168_1	479431.Namu_2316	8.69e-15	80.5	COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria,4EU6S@85013|Frankiales	201174|Actinobacteria	V	PFAM Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
k59_741645_1	1049564.TevJSym_bk00210	6.91e-78	245.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1J4SA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	iYL1228.KPN_02462	AdoHcyase,AdoHcyase_NAD
k59_564670_1	765913.ThidrDRAFT_1438	5.68e-94	279.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,1S23B@1236|Gammaproteobacteria,1WW1Q@135613|Chromatiales	135613|Chromatiales	S	Belongs to the WrbA family	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
k59_288932_1	1463920.JOGB01000060_gene4788	1.19e-52	180.0	COG2072@1|root,COG2072@2|Bacteria,2GMDH@201174|Actinobacteria	201174|Actinobacteria	P	flavoprotein involved in K transport	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
k59_288932_2	367299.JOEE01000001_gene1646	1.24e-40	137.0	COG3467@1|root,COG3467@2|Bacteria,2IP5U@201174|Actinobacteria,4FGWT@85021|Intrasporangiaceae	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Pyridox_ox_2
k59_56146_1	1249627.D779_1342	8.1e-50	164.0	COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,1S4KI@1236|Gammaproteobacteria,1WXNV@135613|Chromatiales	135613|Chromatiales	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_1029989_1	1470593.BW43_04775	7.26e-57	190.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
k59_1386446_1	356851.JOAN01000014_gene1981	8.54e-91	278.0	2CAQZ@1|root,32RRU@2|Bacteria,2ICWM@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1347936_1	935848.JAEN01000021_gene146	4.47e-125	361.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,2PW77@265|Paracoccus	28211|Alphaproteobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_623292_1	1077144.AGFF01000032_gene2943	1.29e-55	188.0	COG0133@1|root,COG0133@2|Bacteria,2GM7Z@201174|Actinobacteria	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PALP
k59_1029995_1	583355.Caka_0487	1.63e-18	87.8	COG0811@1|root,COG0811@2|Bacteria,46SY0@74201|Verrucomicrobia,3K8FG@414999|Opitutae	74201|Verrucomicrobia	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_408082_1	1183438.GKIL_4186	8.03e-13	69.3	COG0845@1|root,COG0845@2|Bacteria,1G49W@1117|Cyanobacteria	1117|Cyanobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
k59_408082_2	1304885.AUEY01000004_gene958	1.62e-44	162.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1562281_1	1479623.JHEL01000012_gene1914	1.58e-37	143.0	COG0489@1|root,COG3944@1|root,COG0489@2|Bacteria,COG3944@2|Bacteria,2GJ1Y@201174|Actinobacteria,4FM6M@85023|Microbacteriaceae	201174|Actinobacteria	D	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,CbiA,ParA,Wzz
k59_288951_1	930166.CD58_04155	1.93e-140	407.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the CarA family	carA	GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1950,iUTI89_1310.UTI89_C0036,ic_1306.c0040	CPSase_sm_chain,GATase
k59_1446198_1	1265503.KB905166_gene652	7.73e-89	288.0	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S0KQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_114577_1	1049564.TevJSym_an00760	1.89e-10	57.8	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,1J68E@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the glutaredoxin family. Monothiol subfamily	grxD	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
k59_114577_2	1121405.dsmv_2273	4.52e-12	67.4	COG2823@1|root,COG2823@2|Bacteria,1Q1QW@1224|Proteobacteria,42U7A@68525|delta/epsilon subdivisions,2X5PY@28221|Deltaproteobacteria,2MKM2@213118|Desulfobacterales	28221|Deltaproteobacteria	S	BON domain	-	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
k59_506157_1	187272.Mlg_1973	6.13e-49	170.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1WW1H@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_56176_1	472759.Nhal_2480	5.57e-133	391.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,1WXJN@135613|Chromatiales	135613|Chromatiales	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1347972_1	1231190.NA8A_18597	1.34e-57	201.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2TTJZ@28211|Alphaproteobacteria,43JFR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1211004_1	911045.PSE_p0368	6.81e-90	273.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2TTP8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	bcpA	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
k59_1277472_1	196164.23492931	3.99e-47	171.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,22KCS@1653|Corynebacteriaceae	201174|Actinobacteria	U	COG0659 Sulfate permease and related transporters (MFS superfamily)	-	GO:0000103,GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006790,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008152,GO:0008272,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0017076,GO:0019001,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0097159,GO:0098656,GO:0098660,GO:0098661,GO:1901265,GO:1901363,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_447488_2	998088.B565_0561	2.21e-44	153.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,1Y3F2@135624|Aeromonadales	135624|Aeromonadales	J	Specifically methylates the ribose of guanosine 2251 in 23S rRNA	rlmB	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
k59_1347980_1	1304865.JAGF01000001_gene436	7.25e-68	212.0	COG1716@1|root,COG1716@2|Bacteria,2GK5I@201174|Actinobacteria,4F1PK@85016|Cellulomonadaceae	201174|Actinobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
k59_564727_2	876044.IMCC3088_1504	2.26e-82	250.0	COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,1S3QT@1236|Gammaproteobacteria,1JANE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
k59_288969_1	1032480.MLP_32070	1.41e-65	216.0	COG0631@1|root,COG0631@2|Bacteria,2GKDM@201174|Actinobacteria,4DN5I@85009|Propionibacteriales	201174|Actinobacteria	T	Serine/threonine phosphatases, family 2C, catalytic domain	prpB10	-	-	-	-	-	-	-	-	-	-	-	DZR,PP2C_2
k59_1386483_1	472759.Nhal_1296	4.57e-55	192.0	COG0369@1|root,COG0369@2|Bacteria,1QUAH@1224|Proteobacteria,1T1RJ@1236|Gammaproteobacteria,1WX4K@135613|Chromatiales	135613|Chromatiales	C	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component	-	-	1.8.1.2	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_1,Flavodoxin_1,NAD_binding_1
k59_330568_1	1349767.GJA_3585	2.48e-10	61.6	COG4254@1|root,COG4254@2|Bacteria,1NBPR@1224|Proteobacteria,2VWWI@28216|Betaproteobacteria,475RE@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
k59_408131_1	1121017.AUFG01000006_gene1142	2.64e-09	57.0	COG0562@1|root,COG0562@2|Bacteria,2GK2Z@201174|Actinobacteria,4FG01@85021|Intrasporangiaceae	201174|Actinobacteria	M	UDP-galactopyranose mutase	glf	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008767,GO:0009273,GO:0009987,GO:0016020,GO:0016853,GO:0016866,GO:0030312,GO:0042546,GO:0044085,GO:0044464,GO:0071554,GO:0071766,GO:0071840,GO:0071944	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3809c	GLF,NAD_binding_8
k59_408131_2	1312954.KI914873_gene856	2.71e-225	647.0	COG1216@1|root,COG1216@2|Bacteria,2GM9N@201174|Actinobacteria,1W870@1268|Micrococcaceae	201174|Actinobacteria	S	Glycosyltransferase like family 2	glfT	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0008610,GO:0008653,GO:0008921,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009273,GO:0009987,GO:0010383,GO:0016020,GO:0016043,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0022607,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0035250,GO:0035496,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045229,GO:0046483,GO:0052573,GO:0055086,GO:0070589,GO:0070592,GO:0071554,GO:0071555,GO:0071704,GO:0071766,GO:0071769,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901576,GO:1903509	2.4.1.288	ko:K16650	-	-	-	-	ko00000,ko01000,ko01003	-	GT2	iNJ661.Rv3808c	Glyco_tranf_2_3
k59_408138_1	1283300.ATXB01000001_gene1805	1.19e-58	198.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,1S0H0@1236|Gammaproteobacteria,1XEM1@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c oxidase, subunit I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_1030056_2	1403819.BATR01000033_gene1104	2.54e-13	68.9	COG0686@1|root,COG0686@2|Bacteria,46S7U@74201|Verrucomicrobia,2ITXS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Alanine dehydrogenase/PNT, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_506195_1	465541.ATCJ01000005_gene4494	1.22e-14	79.0	COG0438@1|root,COG0438@2|Bacteria,2GJBP@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Stealth_CR1,Stealth_CR2,Stealth_CR3,Stealth_CR4
k59_213179_1	2340.JV46_10310	2.21e-74	229.0	COG3439@1|root,COG3439@2|Bacteria,1REDZ@1224|Proteobacteria,1RPW4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_741721_1	292459.STH727	6.6e-05	50.4	COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4,PAS_9
k59_1562330_2	492774.JQMB01000004_gene2095	2.01e-41	145.0	COG1670@1|root,COG1670@2|Bacteria,1RH19@1224|Proteobacteria,2TW1R@28211|Alphaproteobacteria,4BEYB@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	-	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234	-	ko:K03825	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
k59_1030066_1	1174504.AJTN02000221_gene1198	4.36e-06	48.5	COG2071@1|root,COG2071@2|Bacteria,1V1KC@1239|Firmicutes,4HI59@91061|Bacilli,1ZFXS@1386|Bacillus	91061|Bacilli	S	Peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
k59_1030066_2	926569.ANT_04560	6.33e-59	191.0	COG0796@1|root,COG0796@2|Bacteria,2G8GN@200795|Chloroflexi	200795|Chloroflexi	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
k59_1277507_1	1304874.JAFY01000002_gene684	4.66e-54	184.0	COG0031@1|root,COG0031@2|Bacteria,3TA7I@508458|Synergistetes	508458|Synergistetes	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	-	-	2.3.1.263	ko:K21400	-	-	-	-	ko00000,ko01000	-	-	-	PALP
k59_683073_1	765911.Thivi_3759	3.99e-94	292.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,1WWAQ@135613|Chromatiales	135613|Chromatiales	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_408157_1	1380354.JIAN01000005_gene2712	9.72e-117	358.0	COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria	201174|Actinobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_1562331_1	446466.Cfla_3403	3.71e-158	456.0	COG4214@1|root,COG4214@2|Bacteria,2GJAH@201174|Actinobacteria,4F0VZ@85016|Cellulomonadaceae	201174|Actinobacteria	G	Belongs to the binding-protein-dependent transport system permease family	araH	-	-	ko:K10547	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	BPD_transp_2
k59_1562332_1	335543.Sfum_0679	1.55e-77	256.0	COG0617@1|root,COG0618@1|root,COG3620@1|root,COG0617@2|Bacteria,COG0618@2|Bacteria,COG3620@2|Bacteria,1MU2X@1224|Proteobacteria,42MJJ@68525|delta/epsilon subdivisions,2WJBN@28221|Deltaproteobacteria,2MQAY@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	tRNA nucleotidyltransferase poly(A) polymerase	ccaA	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd
k59_1348034_2	454957.IA64_12770	0.000134	47.0	COG3121@1|root,COG3121@2|Bacteria,1R4RJ@1224|Proteobacteria,1T8H2@1236|Gammaproteobacteria,1XAPQ@135614|Xanthomonadales	135614|Xanthomonadales	M	Pilus assembly protein	papD1	-	-	ko:K07346	-	-	-	-	ko00000,ko02035,ko02044,ko03110	-	-	-	PapD_N
k59_995508_1	391615.ABSJ01000054_gene1379	4.49e-89	286.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,1J5BG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_1211048_1	1500304.JQKY01000018_gene768	3.92e-34	134.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,1PH75@1224|Proteobacteria,2VD9Z@28211|Alphaproteobacteria,4BDMD@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_447540_1	1312959.KI914621_gene2424	1.45e-08	55.1	COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria,1W80Z@1268|Micrococcaceae	201174|Actinobacteria	J	Ribosomal protein S1	rpsA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_447540_2	1380354.JIAN01000011_gene3189	8.42e-94	281.0	COG0500@1|root,COG2226@2|Bacteria,2GJSF@201174|Actinobacteria,4F0RG@85016|Cellulomonadaceae	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_1277517_1	1286106.MPL1_09522	1.67e-25	104.0	COG0745@1|root,COG0745@2|Bacteria,1RA00@1224|Proteobacteria,1S23N@1236|Gammaproteobacteria,460J1@72273|Thiotrichales	72273|Thiotrichales	K	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_213202_1	713587.THITH_07390	4.27e-62	214.0	COG0457@1|root,COG0457@2|Bacteria,1QZTW@1224|Proteobacteria,1T54Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
k59_1755132_1	292415.Tbd_2032	5.98e-31	120.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2VHCK@28216|Betaproteobacteria,1KRX4@119069|Hydrogenophilales	119069|Hydrogenophilales	K	HrcA protein C terminal domain	-	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_759480_2	3075.A0A087ST35	7.84e-24	103.0	2BWJ3@1|root,2RXAI@2759|Eukaryota,37VJX@33090|Viridiplantae,34I0V@3041|Chlorophyta	3041|Chlorophyta	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
k59_520279_1	519989.ECTPHS_06517	1.64e-95	288.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1WWT0@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_463275_1	639283.Snov_0081	1.52e-138	432.0	COG0591@1|root,COG0642@1|root,COG0784@1|root,COG0591@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,3EYE9@335928|Xanthobacteraceae	28211|Alphaproteobacteria	T	histidine kinase A domain protein	MA20_19630	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
k59_1755143_1	1123073.KB899242_gene1635	5.75e-64	205.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria,1X36W@135614|Xanthomonadales	135614|Xanthomonadales	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
k59_1699585_1	768671.ThimaDRAFT_1828	6.44e-118	350.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1WWIC@135613|Chromatiales	135613|Chromatiales	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
k59_172516_1	1265505.ATUG01000002_gene1004	8.67e-92	288.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2WIZF@28221|Deltaproteobacteria,2MIKW@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1463521_1	543632.JOJL01000042_gene4523	6.17e-97	292.0	COG0111@1|root,COG0111@2|Bacteria,2GP09@201174|Actinobacteria,4D8JX@85008|Micromonosporales	201174|Actinobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh_C
k59_463299_1	1336245.JAGO01000012_gene1928	3.1e-94	305.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1XHB4@135619|Oceanospirillales	135619|Oceanospirillales	E	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_877748_1	340.xcc-b100_2265	7.6e-41	139.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,1S8Z7@1236|Gammaproteobacteria,1X72N@135614|Xanthomonadales	135614|Xanthomonadales	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
k59_877748_2	395493.BegalDRAFT_1677	1.01e-56	195.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,45ZV1@72273|Thiotrichales	72273|Thiotrichales	O	ATP-dependent Clp protease ATP-binding subunit ClpA	-	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_520302_1	397278.JOJN01000013_gene2572	6.14e-36	133.0	COG2064@1|root,COG2064@2|Bacteria,2HZTC@201174|Actinobacteria,4DRIG@85009|Propionibacteriales	201174|Actinobacteria	NU	type II secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
k59_877767_1	665959.HMPREF1013_04648	7.33e-49	166.0	COG2801@1|root,COG2801@2|Bacteria,1TU21@1239|Firmicutes,4HDK4@91061|Bacilli,1ZB1J@1386|Bacillus	91061|Bacilli	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_1755186_1	1121441.AUCX01000009_gene2519	7.29e-05	43.5	2D7FD@1|root,32TNY@2|Bacteria,1NAHU@1224|Proteobacteria,42VAC@68525|delta/epsilon subdivisions,2WR6Q@28221|Deltaproteobacteria,2MCEJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM DnaJ homologue, subfamily C, member 28	-	-	-	-	-	-	-	-	-	-	-	-	DUF1992
k59_1755186_2	933262.AXAM01000081_gene2256	2.63e-55	178.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,42SJ8@68525|delta/epsilon subdivisions,2WP5B@28221|Deltaproteobacteria,2MJHE@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
k59_1755186_3	880072.Desac_0752	1.78e-15	77.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,42P77@68525|delta/epsilon subdivisions,2WK7E@28221|Deltaproteobacteria,2MQYK@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_1163364_1	667632.KB890170_gene3757	9.97e-25	108.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,1K0BI@119060|Burkholderiaceae	28216|Betaproteobacteria	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_2,Thioredoxin_7
k59_1755201_1	640081.Dsui_2985	9.91e-30	111.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,2VIRB@28216|Betaproteobacteria,2KUZB@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_1755201_2	187272.Mlg_0808	1.71e-49	162.0	2AFCJ@1|root,315C6@2|Bacteria,1RH66@1224|Proteobacteria,1S9MI@1236|Gammaproteobacteria,1WYGK@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF1841)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1841
k59_641099_2	1451261.AS96_04145	9.02e-09	57.0	COG0628@1|root,COG0628@2|Bacteria,2GK0H@201174|Actinobacteria,4FKUH@85023|Microbacteriaceae	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1165746_1	1036674.A28LD_0978	2.05e-32	127.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1S3EU@1236|Gammaproteobacteria,2QGY6@267893|Idiomarinaceae	1236|Gammaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_808851_2	1267533.KB906733_gene3191	2.08e-05	48.9	COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria	2|Bacteria	K	chromosome segregation	-	-	2.1.1.72	ko:K07319	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase,ParBc
k59_701383_1	439235.Dalk_4696	2.94e-40	146.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42M5U@68525|delta/epsilon subdivisions,2WJ06@28221|Deltaproteobacteria,2MHZ7@213118|Desulfobacterales	28221|Deltaproteobacteria	H	TIGRFAM molybdenum cofactor synthesis domain	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_1405890_2	1249627.D779_2339	3.1e-48	164.0	COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,1S95P@1236|Gammaproteobacteria,1WY25@135613|Chromatiales	135613|Chromatiales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
k59_1811743_1	1220582.RRU01S_10_00130	4.21e-41	146.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,4B8X7@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Part of the ABC transporter complex potABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K11076	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	ABC_tran,TOBE_2
k59_1811743_2	670307.HYPDE_31518	1.9e-14	72.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2TSUZ@28211|Alphaproteobacteria,3N685@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	potF	-	-	ko:K11073	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	SBP_bac_6,SBP_bac_8
k59_879966_1	335543.Sfum_1996	7.16e-95	294.0	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,1MXK5@1224|Proteobacteria,42R55@68525|delta/epsilon subdivisions,2WN4E@28221|Deltaproteobacteria,2MQCK@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
k59_1231328_1	1304885.AUEY01000011_gene1759	2.58e-86	267.0	COG0174@1|root,COG0174@2|Bacteria,1R9JP@1224|Proteobacteria,42P33@68525|delta/epsilon subdivisions,2WKP3@28221|Deltaproteobacteria,2MN2Q@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Glutamine synthetase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Gln-synt_C,Gln-synt_N
k59_349610_2	1122604.JONR01000029_gene3345	3.25e-15	74.7	COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,1RQ8M@1236|Gammaproteobacteria,1X3U1@135614|Xanthomonadales	135614|Xanthomonadales	N	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
k59_808861_1	1121091.AUMP01000001_gene576	2.55e-74	237.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli	91061|Bacilli	C	acyl-CoA transferases carnitine dehydratase	bbsF_2	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_1701573_1	477228.YO5_19827	4.58e-42	150.0	COG3156@1|root,COG3156@2|Bacteria,1RBNV@1224|Proteobacteria,1S5US@1236|Gammaproteobacteria,1YZPH@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	U	COG3156 Type II secretory pathway, component PulK	xcpX	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
k59_174548_1	572477.Alvin_2719	1.14e-44	163.0	COG0457@1|root,COG0457@2|Bacteria,1QY6N@1224|Proteobacteria,1T4SY@1236|Gammaproteobacteria,1WX4E@135613|Chromatiales	135613|Chromatiales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	SEC-C
k59_1701580_1	1121382.JQKG01000005_gene3331	1.35e-16	86.3	COG1404@1|root,COG3325@1|root,COG3469@1|root,COG1404@2|Bacteria,COG3325@2|Bacteria,COG3469@2|Bacteria	2|Bacteria	G	chitinase activity	celN	GO:0001871,GO:0003674,GO:0005488,GO:0030246,GO:0030247,GO:0030248	3.2.1.14,3.2.1.78	ko:K01183,ko:K01218	ko00051,ko00520,ko01100,ko02024,map00051,map00520,map01100,map02024	-	R01206,R01332,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18,GH26	-	CBM_2,CBM_5_12_2,Cellulase,DUF5011,Esterase_phd,F5_F8_type_C,Glyco_hydro_18,RicinB_lectin_2,fn3
k59_465611_1	765911.Thivi_1173	3.91e-08	51.2	2EMND@1|root,33FAR@2|Bacteria,1NKUJ@1224|Proteobacteria,1SJFW@1236|Gammaproteobacteria,1WZT5@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_521962_1	377629.TERTU_0897	6.45e-117	345.0	COG0524@1|root,COG0524@2|Bacteria,1QNWF@1224|Proteobacteria,1RRZR@1236|Gammaproteobacteria,2PNXE@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
k59_521962_2	1227261.HMPREF0043_02041	1.14e-12	67.8	COG0800@1|root,COG0800@2|Bacteria,2GNC0@201174|Actinobacteria,4D61G@85005|Actinomycetales	201174|Actinobacteria	G	2-dehydro-3-deoxyphosphogluconate aldolase 4-hydroxy-2-oxoglutarate aldolase	eda	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
k59_761595_1	1122130.AUHN01000004_gene1085	1.75e-66	219.0	COG1080@1|root,COG1080@2|Bacteria,2GIZZ@201174|Actinobacteria	201174|Actinobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_1465117_1	1469245.JFBG01000076_gene140	1.74e-127	374.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,1RQ65@1236|Gammaproteobacteria,1WWT1@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM FeS assembly protein SufB	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_880006_1	556268.OFAG_01291	4.99e-45	157.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2VH2S@28216|Betaproteobacteria,473UY@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
k59_880006_2	1348657.M622_05550	3.62e-98	305.0	COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria,2WHHS@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
k59_232390_1	1415779.JOMH01000001_gene2709	1.63e-07	59.7	COG2207@1|root,COG2207@2|Bacteria,1R4HH@1224|Proteobacteria,1RZA9@1236|Gammaproteobacteria,1X5T2@135614|Xanthomonadales	135614|Xanthomonadales	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_582203_1	34506.g3249	8.46e-50	178.0	COG0275@1|root,KOG2782@2759|Eukaryota,38UFJ@33154|Opisthokonta,3BEK8@33208|Metazoa,3CUSP@33213|Bilateria	33208|Metazoa	M	rRNA (cytosine-N4-)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_5
k59_582207_1	367299.JOEE01000011_gene3214	1.73e-116	342.0	COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria,4FEXA@85021|Intrasporangiaceae	201174|Actinobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	GO:0008150,GO:0040007	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_1053874_1	1249627.D779_0933	1.29e-44	158.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1WX0A@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_1053874_2	261292.Nit79A3_3448	1.22e-15	82.4	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,371MP@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
k59_174604_1	519989.ECTPHS_07326	1.27e-109	338.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWI3@135613|Chromatiales	135613|Chromatiales	L	PFAM UvrD REP helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1405943_1	768066.HELO_2645	8.15e-35	136.0	28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria,1RRNS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1811808_1	67281.JNZZ01000024_gene4782	7.67e-25	105.0	COG2508@1|root,COG2508@2|Bacteria,2GNDH@201174|Actinobacteria,417V0@629295|Streptomyces griseus group	201174|Actinobacteria	QT	Purine catabolism regulatory protein-like family	-	-	-	ko:K09684	-	-	-	-	ko00000,ko03000	-	-	-	HTH_30,PucR
k59_174615_1	1123371.ATXH01000008_gene210	9.93e-87	268.0	COG2864@1|root,COG2864@2|Bacteria	2|Bacteria	C	formate dehydrogenase	fdhC	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
k59_582223_1	338963.Pcar_1391	8.02e-49	161.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,42RIQ@68525|delta/epsilon subdivisions,2WNC7@28221|Deltaproteobacteria,43SKU@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
k59_349688_1	452637.Oter_4043	2.36e-51	183.0	COG0058@1|root,COG0058@2|Bacteria,46S5T@74201|Verrucomicrobia,3K731@414999|Opitutae	414999|Opitutae	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_465693_1	290400.Jann_3107	4.55e-32	118.0	COG1136@1|root,COG1136@2|Bacteria,1RA1K@1224|Proteobacteria,2U7CA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG1136 ABC-type antimicrobial peptide transport system ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1053920_1	744980.TRICHSKD4_3292	3.8e-82	249.0	COG0580@1|root,COG0580@2|Bacteria,1PPTN@1224|Proteobacteria,2TW8M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the MIP aquaporin (TC 1.A.8) family	aqpZ	-	-	-	-	-	-	-	-	-	-	-	MIP
k59_641201_3	686340.Metal_0653	9.71e-16	75.9	COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,1RX1E@1236|Gammaproteobacteria,1XG15@135618|Methylococcales	135618|Methylococcales	IQ	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_232454_1	631362.Thi970DRAFT_01780	8.97e-103	313.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1WWIH@135613|Chromatiales	135613|Chromatiales	CP	PFAM NADH Ubiquinone plastoquinone	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
k59_761667_1	266940.Krad_2954	1.03e-10	62.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_761667_2	367299.JOEE01000005_gene3567	2.55e-93	289.0	COG4177@1|root,COG4177@2|Bacteria,2GJB3@201174|Actinobacteria,4FFQT@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_701504_1	550540.Fbal_1171	3.34e-73	238.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_1757002_1	1500894.JQNN01000001_gene2617	8.82e-76	248.0	COG0303@1|root,COG0746@1|root,COG0303@2|Bacteria,COG0746@2|Bacteria,1MVD5@1224|Proteobacteria,2VH78@28216|Betaproteobacteria,473QZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	moeA2	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_1757002_2	857087.Metme_2388	7.41e-08	53.1	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,1S72P@1236|Gammaproteobacteria,1XF57@135618|Methylococcales	135618|Methylococcales	H	molybdopterin-guanine dinucleotide biosynthesis	mobB	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
k59_349730_1	543632.JOJL01000119_gene274	4.49e-30	114.0	COG2801@1|root,COG2801@2|Bacteria,2I8NF@201174|Actinobacteria	201174|Actinobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,Mu-transpos_C,rve
k59_349730_2	543632.JOJL01000119_gene275	8.55e-42	144.0	COG3267@1|root,COG3267@2|Bacteria,2IA4V@201174|Actinobacteria	201174|Actinobacteria	U	Type II secretory pathway component ExeA	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
k59_1165924_1	768671.ThimaDRAFT_3762	3.64e-76	244.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,1WW0E@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_880108_1	1461693.ATO10_05467	1.23e-08	63.2	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2TVI7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	protein involved in outer membrane biogenesis	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
k59_641234_1	414684.RC1_1466	1.79e-83	263.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TTPD@28211|Alphaproteobacteria,2JQ42@204441|Rhodospirillales	204441|Rhodospirillales	E	Glutamine synthetase, catalytic domain	puuA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_1406009_1	768671.ThimaDRAFT_2361	3.53e-127	374.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales	135613|Chromatiales	P	PFAM TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_1701714_1	550540.Fbal_0680	1e-46	158.0	COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,1RR95@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1	fpr	GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004324,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0016043,GO:0016052,GO:0016226,GO:0016491,GO:0016730,GO:0016731,GO:0019318,GO:0019320,GO:0022607,GO:0031163,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0055114,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1901575,GO:1901700	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	iECIAI39_1322.ECIAI39_3072,iEcSMS35_1347.EcSMS35_4364,iYL1228.KPN_04002	FAD_binding_6,NAD_binding_1
k59_1701714_2	1123368.AUIS01000009_gene2449	3.87e-63	204.0	COG4398@1|root,COG4398@2|Bacteria,1MUX9@1224|Proteobacteria,1RPGR@1236|Gammaproteobacteria,2NCP1@225057|Acidithiobacillales	225057|Acidithiobacillales	S	FIST N domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
k59_808984_1	1255043.TVNIR_1349	7.12e-39	133.0	COG2920@1|root,COG2920@2|Bacteria,1N6BU@1224|Proteobacteria,1S6FJ@1236|Gammaproteobacteria,1WYPC@135613|Chromatiales	135613|Chromatiales	P	part of a sulfur-relay system	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_761730_1	768671.ThimaDRAFT_1032	3.36e-73	244.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_701565_1	1267005.KB911261_gene2355	1.66e-71	235.0	COG2885@1|root,COG2885@2|Bacteria,1PQ3A@1224|Proteobacteria,2TRBD@28211|Alphaproteobacteria,3N6W1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	OmpA family	MA20_43500	-	-	-	-	-	-	-	-	-	-	-	OmpA
k59_465790_1	1123236.KB899377_gene364	2.84e-131	397.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,464Q5@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1811923_1	1163409.UUA_10871	5.29e-72	235.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,1X53W@135614|Xanthomonadales	135614|Xanthomonadales	S	L,D-transpeptidase catalytic domain	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_1054024_1	1112216.JH594426_gene3799	5.62e-72	236.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2K2UN@204457|Sphingomonadales	204457|Sphingomonadales	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_704697_1	1122138.AQUZ01000016_gene283	6.64e-17	75.5	COG5646@1|root,COG5646@2|Bacteria	2|Bacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
k59_704697_2	795797.C497_11208	0.000613	44.7	COG1917@1|root,arCOG02999@2157|Archaea,2XXKM@28890|Euryarchaeota,23W05@183963|Halobacteria	183963|Halobacteria	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_998255_1	1205910.B005_1982	8.73e-12	66.2	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,4EFSA@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma-70 region 2	sigM	GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_998255_2	479432.Sros_4268	1.89e-08	55.8	COG0520@1|root,COG0520@2|Bacteria,2H9MG@201174|Actinobacteria,4EHWB@85012|Streptosporangiales	201174|Actinobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_880999_1	1254432.SCE1572_37790	1.4e-38	147.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,42ZB2@68525|delta/epsilon subdivisions,2WUMC@28221|Deltaproteobacteria,2YUFT@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_998256_1	67332.FM21_11475	3.67e-06	53.1	COG4608@1|root,COG4608@2|Bacteria,2H40I@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_1174328_2	637389.Acaty_c2079	4.37e-22	95.5	COG0775@1|root,COG0775@2|Bacteria,1PETT@1224|Proteobacteria,1T8JA@1236|Gammaproteobacteria,2ND03@225057|Acidithiobacillales	225057|Acidithiobacillales	F	Phosphorylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PNP_UDP_1
k59_348_1	463191.SSEG_02497	6.12e-09	65.9	COG0179@1|root,COG0179@2|Bacteria,2GM9G@201174|Actinobacteria	201174|Actinobacteria	Q	fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
k59_59109_2	933262.AXAM01000077_gene1698	3.87e-38	130.0	2APA5@1|root,31EC7@2|Bacteria,1RHMQ@1224|Proteobacteria,42UND@68525|delta/epsilon subdivisions,2WQK4@28221|Deltaproteobacteria,2MM23@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_763403_1	864073.HFRIS_007014	3.73e-72	243.0	COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,472XU@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_9
k59_1585240_1	471853.Bcav_2432	9.13e-22	90.5	COG1388@1|root,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_1585240_2	1095767.CAHD01000221_gene982	1.01e-26	105.0	COG1974@1|root,COG1974@2|Bacteria,2GMBN@201174|Actinobacteria,4F0QQ@85016|Cellulomonadaceae	201174|Actinobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0042221,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_469855_2	644968.DFW101_2485	6.47e-30	113.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,42RIQ@68525|delta/epsilon subdivisions,2WNC7@28221|Deltaproteobacteria,2MBBN@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	YbhB YbcL family protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
k59_352633_1	1284679.HMPREF1626_08775	1.89e-46	162.0	COG1234@1|root,COG1234@2|Bacteria,2GMEX@201174|Actinobacteria,4D341@85005|Actinomycetales	201174|Actinobacteria	S	Beta-lactamase superfamily domain	yhfI	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_939702_2	1234364.AMSF01000025_gene3680	2.59e-05	55.1	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,1X57Y@135614|Xanthomonadales	135614|Xanthomonadales	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Patatin,cNMP_binding
k59_117660_1	863365.XHC_0876	1.16e-80	252.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1X4QV@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_1526529_1	317025.Tcr_1315	1.78e-46	163.0	COG3203@1|root,COG3203@2|Bacteria,1R5I5@1224|Proteobacteria,1RM86@1236|Gammaproteobacteria,45ZTD@72273|Thiotrichales	72273|Thiotrichales	M	phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
k59_1056978_2	573413.Spirs_3836	7.39e-13	68.6	arCOG07533@1|root,2ZF5I@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
k59_469856_1	1121468.AUBR01000045_gene1788	1.27e-44	159.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,248PJ@186801|Clostridia,42HQH@68295|Thermoanaerobacterales	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_881031_1	710696.Intca_2167	7.29e-122	361.0	COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,4FFFF@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_939712_1	1026882.MAMP_03108	4.21e-26	105.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,46048@72273|Thiotrichales	72273|Thiotrichales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_939712_2	396588.Tgr7_0775	2.92e-76	238.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1WXJ6@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_1291932_1	107635.AZUO01000001_gene1849	2.5e-15	75.5	COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,2TTEI@28211|Alphaproteobacteria,36XQA@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
k59_1291932_2	876269.ARWA01000001_gene2346	7.96e-09	53.9	2EFTF@1|root,32ZP1@2|Bacteria,1NCWK@1224|Proteobacteria,2UGND@28211|Alphaproteobacteria,3NBMT@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2842)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2842
k59_369_1	1123065.ATWL01000003_gene630	3.5e-172	502.0	COG0046@1|root,COG0046@2|Bacteria,2GKG6@201174|Actinobacteria	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_1233079_1	648885.KB316282_gene1071	6.88e-36	134.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,2TS2U@28211|Alphaproteobacteria,1JSBS@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_763414_1	1410668.JNKC01000004_gene89	1.91e-78	262.0	COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,249UZ@186801|Clostridia,36VWR@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 2 family	lacZ	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_1056991_1	367299.JOEE01000012_gene3247	2e-45	160.0	COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria,4FGN4@85021|Intrasporangiaceae	201174|Actinobacteria	E	GMC oxidoreductase	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_1056991_2	367299.JOEE01000012_gene3257	1.33e-92	280.0	COG4175@1|root,COG4175@2|Bacteria,2GJC0@201174|Actinobacteria,4FGC2@85021|Intrasporangiaceae	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.32	ko:K02000	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	-	ABC_tran,CBS
k59_1233082_1	744979.R2A130_0099	6.71e-20	90.5	COG3713@1|root,COG3713@2|Bacteria,1N0BC@1224|Proteobacteria,2U7QE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	MltA-interacting MipA family protein	-	-	-	-	-	-	-	-	-	-	-	-	MipA
k59_1585255_1	935839.JAGJ01000011_gene414	1.71e-40	148.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
k59_1350479_1	713586.KB900536_gene3056	3.72e-83	259.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1WW6G@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1467902_2	545276.KB898731_gene2226	7.31e-25	99.4	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,1S40D@1236|Gammaproteobacteria,1X0W2@135613|Chromatiales	135613|Chromatiales	S	PFAM cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
k59_528587_1	717231.Flexsi_1535	1.13e-16	84.7	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_1526541_1	765912.Thimo_1085	5.05e-156	454.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1WWGK@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
k59_1761392_1	1121405.dsmv_1647	6.13e-52	185.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,42MD4@68525|delta/epsilon subdivisions,2WJ7Z@28221|Deltaproteobacteria,2MIAK@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM ATP-dependent helicase HrpA	hrpA	-	3.6.4.13	ko:K03578,ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_117683_2	1122604.JONR01000009_gene2385	1.21e-22	95.1	COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,1X3QH@135614|Xanthomonadales	135614|Xanthomonadales	L	Belongs to the DnaA family. HdA subfamily	hda	-	-	ko:K10763	-	-	-	-	ko00000,ko03032	-	-	-	Bac_DnaA,IstB_IS21
k59_1820328_1	584708.Apau_0398	3.1e-12	72.0	COG1807@1|root,COG1807@2|Bacteria,3TAR6@508458|Synergistetes	508458|Synergistetes	M	PFAM glycosyl transferase family 39	-	-	2.4.2.43	ko:K07264	ko01503,map01503	M00721	R09773,R09774,R09781	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	-	-	PMT_2
k59_59175_1	391615.ABSJ01000023_gene349	2.71e-29	115.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,1J5AS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_176391_1	1123401.JHYQ01000015_gene1363	1.01e-111	340.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,46009@72273|Thiotrichales	72273|Thiotrichales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_1174370_1	572477.Alvin_3279	1.1e-82	255.0	COG1737@1|root,COG1737@2|Bacteria,1R6H8@1224|Proteobacteria,1RYJ6@1236|Gammaproteobacteria,1WXTQ@135613|Chromatiales	135613|Chromatiales	K	Protein of unknown function (DUF3150)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3150
k59_1057016_1	1220535.IMCC14465_10610	3.9e-69	235.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,4BPPZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1233103_1	630626.EBL_c25560	1.06e-10	62.8	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,1RM7W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Required for the activity of the bacterial periplasmic transport system of putrescine	potF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0019808,GO:0019810,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0051179,GO:0051234,GO:0070405,GO:0071702,GO:0071705	-	ko:K11073	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	iB21_1397.B21_00865,iECBD_1354.ECBD_2740,iECB_1328.ECB_00859,iECD_1391.ECD_00859,iEcHS_1320.EcHS_A0957,iEcolC_1368.EcolC_2742,iPC815.YPO1331	SBP_bac_8
k59_1233103_2	504832.OCAR_6504	1.36e-69	224.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2TSUZ@28211|Alphaproteobacteria,3JUJ4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Required for the activity of the bacterial periplasmic transport system of putrescine	potF	-	-	ko:K11073	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	SBP_bac_6,SBP_bac_8
k59_822202_1	105559.Nwat_2073	1.21e-32	122.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1WZ4R@135613|Chromatiales	135613|Chromatiales	BQ	PFAM histone deacetylase superfamily	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
k59_822202_2	1318628.MARLIPOL_17428	1.49e-82	256.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,4641N@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_59217_1	95619.PM1_0202530	5.21e-22	90.9	COG3917@1|root,COG3917@2|Bacteria,1MWB9@1224|Proteobacteria,1S4K8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	2-hydroxychromene-2-carboxylate isomerase	-	-	5.99.1.4	ko:K14584	ko00626,ko01100,ko01120,ko01220,map00626,map01100,map01120,map01220	M00534	R05137	RC03084	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	DSBA
k59_822203_1	506534.Rhein_0999	5.84e-35	130.0	COG2978@1|root,COG2978@2|Bacteria,1MUJ1@1224|Proteobacteria,1RMAI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	transporter	abgT	-	-	ko:K12942	-	-	-	-	ko00000	-	-	-	ABG_transport
k59_1644068_1	1288494.EBAPG3_2240	5.75e-31	125.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,371ME@32003|Nitrosomonadales	28216|Betaproteobacteria	CJ	CoA binding domain	yfiQ	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_352741_2	525903.Taci_1142	1.1e-13	69.7	COG0727@1|root,COG0727@2|Bacteria,3TBB7@508458|Synergistetes	508458|Synergistetes	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_59227_1	1249627.D779_3859	2.33e-44	155.0	COG0500@1|root,COG2226@2|Bacteria,1QYM4@1224|Proteobacteria,1RYUE@1236|Gammaproteobacteria,1X04Z@135613|Chromatiales	135613|Chromatiales	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_1409198_1	1121451.DESAM_20813	1.24e-30	116.0	COG2203@1|root,COG2203@2|Bacteria,1RHTM@1224|Proteobacteria,42SY3@68525|delta/epsilon subdivisions,2WP4G@28221|Deltaproteobacteria,2MADU@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM GAF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2
k59_352747_1	1110502.TMO_3325	1.73e-48	176.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2JPV8@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1042 Acyl-CoA synthetase (NDP forming)	yfiQ	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_998341_2	1123517.JOMR01000001_gene615	1.3e-05	48.5	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,45ZXR@72273|Thiotrichales	72273|Thiotrichales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_1233126_1	519989.ECTPHS_01879	6.03e-88	273.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1WW6B@135613|Chromatiales	135613|Chromatiales	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_528616_1	1049564.TevJSym_au00160	1.08e-258	728.0	COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,1J4XK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB	hscA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051604,GO:0051716,GO:0070417,GO:0071704,GO:0097159,GO:0097367,GO:0097428,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1990230,GO:1990234	-	ko:K04044	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
k59_528616_2	1049564.TevJSym_au00170	1.62e-25	97.4	COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,1S5XW@1236|Gammaproteobacteria,1J6AQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	ferredoxin, 2Fe-2S	fdx	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
k59_704774_1	929703.KE386491_gene540	5.42e-09	60.8	COG1529@1|root,COG1529@2|Bacteria,4NFFU@976|Bacteroidetes,47N2K@768503|Cytophagia	976|Bacteroidetes	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_704774_2	272630.MexAM1_META1p4978	4.87e-65	202.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U6Z6@28211|Alphaproteobacteria,1JS9I@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	2Fe-2S -binding domain protein	MA20_34360	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_1526569_1	382464.ABSI01000013_gene1559	4.59e-44	164.0	COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria,46WZH@74201|Verrucomicrobia,2IVZE@203494|Verrucomicrobiae	2|Bacteria	K	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C
k59_1820403_1	305900.GV64_19995	3.13e-32	126.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1XI0R@135619|Oceanospirillales	135619|Oceanospirillales	I	Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA	ivd	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_462_1	880072.Desac_1741	2.34e-103	323.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2WJ3E@28221|Deltaproteobacteria,2MQ60@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	TIGRFAM leucyl-tRNA synthetase	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_2300	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1057063_1	1415779.JOMH01000001_gene2490	5.14e-07	51.2	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1S9P2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1
k59_1820421_1	386415.NT01CX_1206	5.19e-65	216.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,36QTE@31979|Clostridiaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_998360_1	580332.Slit_1608	1.23e-175	509.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VHW2@28216|Betaproteobacteria,44W82@713636|Nitrosomonadales	28216|Betaproteobacteria	C	NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding	hoxF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.12.1.2	ko:K18005	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_822248_1	933262.AXAM01000022_gene3241	1.59e-62	215.0	COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,42NGA@68525|delta/epsilon subdivisions,2WJK3@28221|Deltaproteobacteria,2MJ23@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	TIGRFAM Polyketide-type polyunsaturated fatty acid synthase, PfaA	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,FabA,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
k59_411249_1	471853.Bcav_0029	7.25e-28	112.0	COG0772@1|root,COG0772@2|Bacteria,2GJTI@201174|Actinobacteria	201174|Actinobacteria	D	Belongs to the SEDS family	rodA	GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_411249_2	1121924.ATWH01000025_gene1346	4.69e-20	93.2	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4FKJ0@85023|Microbacteriaceae	201174|Actinobacteria	T	Protein phosphatase 2C	pstP	GO:0000287,GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010563,GO:0010605,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0030145,GO:0030312,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0033673,GO:0036211,GO:0042325,GO:0042326,GO:0042578,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043392,GO:0043412,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0045859,GO:0045936,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051098,GO:0051100,GO:0051101,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
k59_528649_1	404589.Anae109_1955	2.88e-60	201.0	COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,42R3H@68525|delta/epsilon subdivisions,2WMNY@28221|Deltaproteobacteria,2YUZU@29|Myxococcales	28221|Deltaproteobacteria	D	NUBPL iron-transfer P-loop NTPase	-	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,HTH_25,ParA
k59_704808_1	401526.TcarDRAFT_1832	5.87e-85	265.0	COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,4H293@909932|Negativicutes	909932|Negativicutes	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	abfD	-	4.2.1.120,5.3.3.3	ko:K14534	ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R03031,R10782	RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
k59_497_1	1006004.GBAG_3352	1.6e-38	145.0	COG1538@1|root,COG1538@2|Bacteria,1MYX2@1224|Proteobacteria,1RNX1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	MU	type I secretion outer membrane protein, TolC	aggA	-	-	ko:K12543	-	M00330	-	-	ko00000,ko00002,ko02000,ko02044	1.B.17,3.A.1.109.4	-	-	OEP,OmpA
k59_235232_1	1370121.AUWS01000044_gene1327	1.34e-29	115.0	COG2453@1|root,COG2453@2|Bacteria,2I1Z5@201174|Actinobacteria,2379A@1762|Mycobacteriaceae	201174|Actinobacteria	T	Cyclin-dependent kinase inhibitor 3 (CDKN3)	-	-	-	-	-	-	-	-	-	-	-	-	CDKN3,Y_phosphatase3
k59_353886_2	1501391.LG35_03990	7.68e-14	74.3	COG0716@1|root,COG4925@1|root,COG0716@2|Bacteria,COG4925@2|Bacteria,4NQA7@976|Bacteroidetes,2FSHV@200643|Bacteroidia	976|Bacteroidetes	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1703350_1	1249627.D779_3800	3.21e-39	139.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,1RNDY@1236|Gammaproteobacteria,1WW3H@135613|Chromatiales	135613|Chromatiales	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
k59_1703350_2	1123377.AUIV01000005_gene1695	6.65e-156	459.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1X2YR@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_537423_2	1112204.GPOL_c49660	3.02e-05	50.4	COG0500@1|root,COG0500@2|Bacteria,2I3NZ@201174|Actinobacteria,4GBNQ@85026|Gordoniaceae	201174|Actinobacteria	Q	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
k59_1593372_1	994479.GL877881_gene6425	4.36e-17	86.7	COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,2H477@201174|Actinobacteria,4DZDB@85010|Pseudonocardiales	201174|Actinobacteria	Q	polyketide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
k59_770757_2	439235.Dalk_2237	4.01e-40	145.0	COG0477@1|root,COG2814@2|Bacteria,1R518@1224|Proteobacteria,43B4F@68525|delta/epsilon subdivisions,2WIQ4@28221|Deltaproteobacteria,2MIEM@213118|Desulfobacterales	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1005713_1	1267535.KB906767_gene3674	2.6e-143	412.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	MA20_02630	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_71948_1	1395571.TMS3_0115105	1.48e-27	114.0	COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,1RP39@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_1359029_1	338963.Pcar_0188	3.79e-28	119.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,42MB2@68525|delta/epsilon subdivisions,2WJAF@28221|Deltaproteobacteria,43U8C@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	POTRA domain TamA domain 1	-	-	-	ko:K07277,ko:K07278	-	-	-	-	ko00000,ko02000,ko03029	1.B.33,1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,POTRA_TamA_1
k59_478601_1	323261.Noc_1573	8.67e-30	111.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1WYRM@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_1478745_1	713586.KB900536_gene1640	2.06e-76	248.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1WVXZ@135613|Chromatiales	135613|Chromatiales	MU	type I secretion outer membrane protein, TolC	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
k59_1833006_1	1134912.AJTV01000023_gene2878	1.99e-18	86.3	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria,36Y6U@31993|Methylocystaceae	28211|Alphaproteobacteria	MU	Outer membrane efflux protein	oprN	-	-	ko:K18300,ko:K19593	-	M00641,M00769	-	-	ko00000,ko00002,ko01504,ko02000	1.B.17,2.A.6.2.34	-	-	OEP
k59_1833006_2	1218075.BAYA01000029_gene5777	4.47e-08	54.3	COG4943@1|root,COG4943@2|Bacteria,1MVTH@1224|Proteobacteria,2VNSA@28216|Betaproteobacteria,1K46Y@119060|Burkholderiaceae	28216|Betaproteobacteria	T	CSS motif domain associated with EAL	-	-	-	-	-	-	-	-	-	-	-	-	CSS-motif,EAL
k59_1005719_1	1249627.D779_0035	6.39e-39	146.0	COG0642@1|root,COG2204@1|root,COG2204@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1WW92@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_1005719_2	1347369.CCAD010000090_gene1907	2.56e-29	116.0	COG1914@1|root,COG1914@2|Bacteria,1V04N@1239|Firmicutes,4HBF6@91061|Bacilli,1ZF5E@1386|Bacillus	91061|Bacilli	P	Natural resistance-associated macrophage protein	mntH_2	-	-	-	-	-	-	-	-	-	-	-	Nramp
k59_478602_2	1265502.KB905944_gene699	6.24e-37	129.0	COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,2VQBI@28216|Betaproteobacteria,4AEP7@80864|Comamonadaceae	28216|Betaproteobacteria	S	NnrU protein	nnrU	-	-	-	-	-	-	-	-	-	-	-	NnrU
k59_1833009_1	933262.AXAM01000010_gene1376	1.82e-71	226.0	COG1619@1|root,COG1619@2|Bacteria,1MWIY@1224|Proteobacteria,42Q52@68525|delta/epsilon subdivisions,2WJ3S@28221|Deltaproteobacteria,2MICC@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM peptidase U61 LD-carboxypeptidase A	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
k59_248638_1	396588.Tgr7_0097	6.7e-107	326.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWES@135613|Chromatiales	135613|Chromatiales	L	DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation	deaD	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
k59_302498_1	292459.STH1095	1.33e-36	141.0	COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia	186801|Clostridia	P	Potassium uptake protein	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_655093_1	1254432.SCE1572_14910	1.55e-50	181.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2YUAS@29|Myxococcales	28221|Deltaproteobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	ctpF	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_14970_1	316067.Geob_3515	1.77e-55	188.0	COG0683@1|root,COG0683@2|Bacteria,1MX94@1224|Proteobacteria	1224|Proteobacteria	E	Extracellular liganD-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	DctP,Peripla_BP_6
k59_302507_1	262316.MAP_2768c	2.58e-37	138.0	COG0582@1|root,COG0582@2|Bacteria,2GISN@201174|Actinobacteria,2371D@1762|Mycobacteriaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	intA	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
k59_1068235_1	1304865.JAGF01000001_gene440	5.35e-98	299.0	28JK9@1|root,2ZB7T@2|Bacteria,2I80S@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1068235_2	1304865.JAGF01000001_gene441	1.28e-124	363.0	COG0834@1|root,COG0834@2|Bacteria,2GJH8@201174|Actinobacteria,4F255@85016|Cellulomonadaceae	201174|Actinobacteria	ET	Bacterial periplasmic substrate-binding proteins	glnH	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_1304899_1	1123393.KB891316_gene1845	3.29e-84	254.0	COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,2VPFB@28216|Betaproteobacteria,1KRZA@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Nitrate reductase gamma subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_gam
k59_1478777_1	1454004.AW11_03121	3.09e-61	204.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria	28216|Betaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_419785_1	446471.Xcel_0998	1.4e-51	166.0	COG0295@1|root,COG0295@2|Bacteria,2IHP7@201174|Actinobacteria,4F4SD@85017|Promicromonosporaceae	201174|Actinobacteria	F	Cytidine and deoxycytidylate deaminase zinc-binding region	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1,dCMP_cyt_deam_2
k59_419785_2	267747.PPA1731	1.32e-32	124.0	COG1079@1|root,COG1079@2|Bacteria,2GKMB@201174|Actinobacteria,4DN21@85009|Propionibacteriales	201174|Actinobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_655104_1	765913.ThidrDRAFT_0340	9.26e-82	251.0	COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,1RPHX@1236|Gammaproteobacteria,1WXIR@135613|Chromatiales	135613|Chromatiales	S	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation	-	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
k59_655104_2	396588.Tgr7_2061	2.22e-05	45.4	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria,1WW81@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM Serine O-acetyltransferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
k59_1005742_2	1121405.dsmv_0212	3.48e-35	129.0	COG1090@1|root,COG1090@2|Bacteria,1MUB4@1224|Proteobacteria,42QUU@68525|delta/epsilon subdivisions,2WKRY@28221|Deltaproteobacteria,2MJ1I@213118|Desulfobacterales	28221|Deltaproteobacteria	S	epimerase dehydratase	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
k59_1478789_1	207954.MED92_15835	1.46e-90	276.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1XIQQ@135619|Oceanospirillales	135619|Oceanospirillales	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_126779_1	1121104.AQXH01000006_gene2320	3.85e-39	145.0	COG2913@1|root,COG2913@2|Bacteria,4NPBV@976|Bacteroidetes,1J0YS@117747|Sphingobacteriia	976|Bacteroidetes	J	Pfam:SusD	-	-	-	ko:K21572	-	-	-	-	ko00000,ko02000	8.A.46.1,8.A.46.3	-	-	SusD-like_3,SusD_RagB
k59_1123140_1	398511.BpOF4_13365	1.11e-38	142.0	COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,4HAMF@91061|Bacilli,1ZB7J@1386|Bacillus	91061|Bacilli	J	Methylates ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
k59_952712_1	314287.GB2207_10471	3.4e-15	74.7	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,1J52U@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	COG1077 Actin-like ATPase involved in cell morphogenesis	mreB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_952712_2	1240350.AMZE01000051_gene849	3.8e-25	97.8	COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,1S8VY@1236|Gammaproteobacteria,1YYV8@136845|Pseudomonas putida group	1236|Gammaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
k59_952712_3	232346.JHQL01000003_gene254	8.7e-47	164.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1XHA4@135619|Oceanospirillales	135619|Oceanospirillales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_302517_1	471223.GWCH70_0992	1.04e-10	65.1	COG2340@1|root,COG2340@2|Bacteria,1UYZ4@1239|Firmicutes,4HBTC@91061|Bacilli,1WERA@129337|Geobacillus	91061|Bacilli	S	CAP-associated N-terminal	ylbC	-	-	-	-	-	-	-	-	-	-	-	CAP,CAP_assoc_N
k59_302517_2	880073.Calab_3424	7.65e-82	254.0	COG3698@1|root,COG3698@2|Bacteria,2NR44@2323|unclassified Bacteria	2|Bacteria	S	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA
k59_1123144_1	933262.AXAM01000060_gene2884	1.75e-69	224.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42QBN@68525|delta/epsilon subdivisions,2WK9R@28221|Deltaproteobacteria,2MJF9@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	Na_sulph_symp,Response_reg
k59_16476_2	748449.Halha_0064	4.35e-13	68.9	COG4123@1|root,COG4123@2|Bacteria,1TQ25@1239|Firmicutes,249UH@186801|Clostridia,3WAQY@53433|Halanaerobiales	186801|Clostridia	S	PFAM methyltransferase small	yfiC	-	2.1.1.223	ko:K15460	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MTS,Methyltransf_31
k59_1535674_1	204669.Acid345_4540	8.95e-28	110.0	COG0462@1|root,COG0462@2|Bacteria,3Y3KV@57723|Acidobacteria,2JHTF@204432|Acidobacteriia	204432|Acidobacteriia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_1305950_1	880072.Desac_1953	6.88e-67	220.0	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,42N9J@68525|delta/epsilon subdivisions,2WK7H@28221|Deltaproteobacteria,2MRNI@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Membrane protein involved in aromatic hydrocarbon degradation	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_366537_1	439235.Dalk_2069	4.41e-56	190.0	COG2233@1|root,COG2233@2|Bacteria,1MUN9@1224|Proteobacteria,42M4U@68525|delta/epsilon subdivisions,2WJAG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	PFAM Xanthine uracil vitamin C permease	-	-	-	ko:K03458,ko:K16345	-	-	-	-	ko00000,ko02000	2.A.40,2.A.40.4.2	-	-	Xan_ur_permease
k59_1006343_1	590998.Celf_2477	4.49e-88	268.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4F1TH@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM ATPase associated with various cellular activities AAA_3	moxR2	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1069275_1	1298867.AUES01000059_gene4745	4.26e-50	175.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2TU9Q@28211|Alphaproteobacteria,3JW1M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_953778_1	492774.JQMB01000019_gene4965	9.74e-75	247.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,4B7RZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Cation transport ATPase	actP	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
k59_714523_1	472759.Nhal_3142	6.26e-75	251.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales	135613|Chromatiales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_16492_1	743721.Psesu_1834	1.29e-91	288.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1X2Y0@135614|Xanthomonadales	135614|Xanthomonadales	CP	NADH ubiquinone oxidoreductase subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_1069283_1	83406.HDN1F_05790	2.75e-45	158.0	COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,1RNI1@1236|Gammaproteobacteria,1J5SQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Specifically methylates the adenine in position 2030 of 23S rRNA	rlmJ	-	2.1.1.266	ko:K07115	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RsmJ
k59_479370_1	1288494.EBAPG3_19910	1.86e-07	53.5	28PU4@1|root,33ET9@2|Bacteria,1NIW5@1224|Proteobacteria,2WFI7@28216|Betaproteobacteria,374PX@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_479370_2	1191523.MROS_1186	1.32e-10	62.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114	-	ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT,Cytochrom_c3_2
k59_1359734_1	1122212.AULO01000010_gene267	1.05e-48	170.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1XHK9@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
k59_953790_1	522373.Smlt0975	2.19e-28	115.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1X46J@135614|Xanthomonadales	135614|Xanthomonadales	FP	Belongs to the GppA Ppx family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_1244857_1	1121405.dsmv_0791	2.2e-08	55.1	COG1651@1|root,COG1651@2|Bacteria,1RKYF@1224|Proteobacteria,42T64@68525|delta/epsilon subdivisions,2WP82@28221|Deltaproteobacteria,2MNDC@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
k59_1244857_2	246197.MXAN_3206	4.61e-21	95.5	COG1651@1|root,COG1651@2|Bacteria,1RKYF@1224|Proteobacteria,42T64@68525|delta/epsilon subdivisions,2WP82@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Protein-disulfide isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
k59_1006348_1	909613.UO65_4221	1.18e-05	46.6	COG0460@1|root,COG0460@2|Bacteria,2GIX9@201174|Actinobacteria,4E08Y@85010|Pseudonocardiales	201174|Actinobacteria	E	homoserine dehydrogenase	hom	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.1.1.3,2.7.2.4	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1294	ACT,Homoserine_dh,NAD_binding_3
k59_1006348_2	471853.Bcav_1280	3.7e-193	551.0	COG0019@1|root,COG0019@2|Bacteria,2GKAI@201174|Actinobacteria	201174|Actinobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_1123768_1	1124780.ANNU01000013_gene3785	4.31e-19	91.7	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47NWV@768503|Cytophagia	976|Bacteroidetes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_16518_1	485915.Dret_2125	9.8e-90	280.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,42PV9@68525|delta/epsilon subdivisions,2WJ1M@28221|Deltaproteobacteria,2MG4I@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls-2	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
k59_1069297_1	1123255.JHYS01000003_gene2767	3.3e-60	209.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2VJCZ@28216|Betaproteobacteria,4AAY1@80864|Comamonadaceae	28216|Betaproteobacteria	O	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	ppiD	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
k59_1535694_1	105420.BBPO01000001_gene80	3.57e-21	95.1	COG2897@1|root,COG2897@2|Bacteria,2GMDR@201174|Actinobacteria,2NG8T@228398|Streptacidiphilus	201174|Actinobacteria	P	Rhodanese Homology Domain	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_1184333_1	1313172.YM304_33560	1.01e-93	286.0	COG1260@1|root,COG1260@2|Bacteria,2GKHB@201174|Actinobacteria,4CNE8@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Myo-inositol-1-phosphate synthase	ino1	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
k59_127579_1	292415.Tbd_0985	2.81e-50	172.0	COG4360@1|root,COG4360@2|Bacteria,1RB5I@1224|Proteobacteria,2W0KI@28216|Betaproteobacteria	28216|Betaproteobacteria	F	ATP adenylyltransferase (5',5''-P-1,P-4-tetraphosphate phosphorylase II)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_538198_1	1463821.JOGR01000004_gene2341	1.26e-12	71.2	COG3119@1|root,COG3119@2|Bacteria,2H59R@201174|Actinobacteria,4EZJN@85014|Glycomycetales	201174|Actinobacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_538198_2	1064537.AGSO01000009_gene2247	3.28e-12	67.0	COG3387@1|root,COG3387@2|Bacteria,2ICV9@201174|Actinobacteria,4FBE5@85020|Dermabacteraceae	201174|Actinobacteria	G	Glycoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1711868_1	76114.ebA1167	9.55e-83	271.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2VI9F@28216|Betaproteobacteria,2KUMU@206389|Rhodocyclales	206389|Rhodocyclales	H	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_73071_1	519989.ECTPHS_02526	3.38e-93	279.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1WX43@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
k59_1535700_1	553385.JEMF01000021_gene3109	8.54e-21	85.1	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1XJH4@135619|Oceanospirillales	135619|Oceanospirillales	K	at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA)	glnK-2	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
k59_1535700_2	765911.Thivi_3470	2.63e-42	151.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1WWT4@135613|Chromatiales	135613|Chromatiales	U	Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_831695_1	358220.C380_01315	1.7e-56	199.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2VP2B@28216|Betaproteobacteria,4ABCX@80864|Comamonadaceae	28216|Betaproteobacteria	V	TIGRFAM type I secretion system ATPase	-	-	-	ko:K12541	ko02010,map02010	M00330	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.3,3.A.1.109.4	-	-	ABC_membrane,ABC_tran,Peptidase_C39
k59_479386_1	1249627.D779_0883	6.11e-64	209.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1WX2U@135613|Chromatiales	135613|Chromatiales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_596619_1	314345.SPV1_08456	1.95e-128	386.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria	1224|Proteobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	-	-	-	-	-	-	-	-	-	-	-	-	XFP,XFP_N
k59_1419316_1	1123322.KB904676_gene3065	1.61e-60	199.0	COG0619@1|root,COG0619@2|Bacteria,2GKQ7@201174|Actinobacteria	201174|Actinobacteria	P	Cobalt ABC transporter	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
k59_538202_1	1089553.Tph_c11760	8.43e-77	244.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,42IGZ@68295|Thermoanaerobacterales	186801|Clostridia	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_1305997_1	1267535.KB906767_gene2927	1.72e-28	114.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1305997_2	448385.sce4158	4.7e-80	258.0	COG3385@1|root,COG3385@2|Bacteria,1MXYG@1224|Proteobacteria,430KD@68525|delta/epsilon subdivisions,2WVSS@28221|Deltaproteobacteria,2YZ09@29|Myxococcales	28221|Deltaproteobacteria	L	High confidence in function and specificity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4338,Dimer_Tnp_Tn5,Tnp_DNA_bind
k59_1069321_1	247639.MGP2080_08776	5.94e-57	185.0	COG1999@1|root,COG1999@2|Bacteria,1REUE@1224|Proteobacteria,1SBGQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
k59_1834189_1	765912.Thimo_1195	7.8e-84	261.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1WWJH@135613|Chromatiales	135613|Chromatiales	E	peptidase M24B, X-Pro dipeptidase aminopeptidase	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_1834189_2	314278.NB231_13206	2.69e-36	136.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1WW09@135613|Chromatiales	135613|Chromatiales	CH	Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	-	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_831702_1	640511.BC1002_2090	1.61e-84	264.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2VI3U@28216|Betaproteobacteria,1K2CP@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_894832_1	1174684.EBMC1_11405	5.2e-11	68.6	COG0708@1|root,COG3210@1|root,COG3468@1|root,COG4625@1|root,COG0708@2|Bacteria,COG3210@2|Bacteria,COG3468@2|Bacteria,COG4625@2|Bacteria,1QUXB@1224|Proteobacteria,2TX5F@28211|Alphaproteobacteria,2KEGN@204457|Sphingomonadales	204457|Sphingomonadales	MU	Putative Ig domain	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,He_PIG,TIG
k59_303289_1	1110697.NCAST_20_00610	2.49e-48	171.0	COG1215@1|root,COG1215@2|Bacteria,2GJTE@201174|Actinobacteria,4FV9B@85025|Nocardiaceae	201174|Actinobacteria	M	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
k59_831704_1	1117958.PE143B_0115590	4.34e-116	363.0	COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,1T1GD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	(ABC) transporter	-	-	-	ko:K13926	-	-	-	-	ko00000	-	-	-	ABC2_membrane_3,ABC_tran
k59_16568_1	948106.AWZT01000007_gene3601	4.3e-107	319.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2VH91@28216|Betaproteobacteria,1K14U@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_1184353_1	1206733.BAGC01000044_gene850	7.22e-08	52.4	COG1308@1|root,COG1308@2|Bacteria,2GVBU@201174|Actinobacteria	201174|Actinobacteria	K	Domain of unknown function (DUF4342)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
k59_831708_1	314285.KT71_06474	2.46e-23	102.0	COG1566@1|root,COG1566@2|Bacteria,1R50C@1224|Proteobacteria,1S9AT@1236|Gammaproteobacteria,1J9QW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Protein of unknown function (DUF3667)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3667
k59_771440_1	1000565.METUNv1_02549	1.36e-64	204.0	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,2VJCP@28216|Betaproteobacteria,2KW05@206389|Rhodocyclales	206389|Rhodocyclales	S	SNARE associated Golgi protein	dedA	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
k59_420574_1	1469245.JFBG01000080_gene290	9.91e-70	221.0	COG1163@1|root,COG1163@2|Bacteria,1RFPD@1224|Proteobacteria	1224|Proteobacteria	S	TGS domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,TGS
k59_1314751_2	768671.ThimaDRAFT_0881	3.68e-23	98.2	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1WW9V@135613|Chromatiales	135613|Chromatiales	J	TIGRFAM ribonuclease, Rne Rng family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_662292_1	991905.SL003B_1626	1.82e-37	132.0	COG0596@1|root,COG0596@2|Bacteria,1MW2P@1224|Proteobacteria,2TSS3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Alpha beta hydrolase	MA20_32265	-	1.11.1.10	ko:K00433	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
k59_903606_1	234831.PSM_A0099	9.87e-05	42.0	2DQEA@1|root,3369X@2|Bacteria,1NDK6@1224|Proteobacteria,1SE34@1236|Gammaproteobacteria,2Q3K0@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	Prokaryotic lipoprotein-attachment site	-	-	-	-	-	-	-	-	-	-	-	-	LPAM_2
k59_903606_2	768671.ThimaDRAFT_1287	2.89e-205	578.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1WVUW@135613|Chromatiales	135613|Chromatiales	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_1011472_1	383372.Rcas_2265	8.02e-13	69.7	COG0475@1|root,COG0475@2|Bacteria,2G6B0@200795|Chloroflexi,375SB@32061|Chloroflexia	32061|Chloroflexia	P	PFAM sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1011472_2	748280.NH8B_3656	1.71e-16	79.7	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,2KQ3F@206351|Neisseriales	206351|Neisseriales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_25534_1	1322246.BN4_10122	9.94e-67	214.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2WJ5Y@28221|Deltaproteobacteria,2M9IV@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_1011475_1	1528106.JRJE01000002_gene1999	8.32e-56	188.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2TQVF@28211|Alphaproteobacteria,2JQG6@204441|Rhodospirillales	204441|Rhodospirillales	L	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_1660599_1	305900.GV64_21200	0.000365	43.1	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,1RN6S@1236|Gammaproteobacteria,1XJ5D@135619|Oceanospirillales	135619|Oceanospirillales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1314776_1	1266908.AQPB01000050_gene1849	1.03e-24	102.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1WX3U@135613|Chromatiales	135613|Chromatiales	C	PFAM Alcohol dehydrogenase	-	-	-	ko:K19745	ko00640,ko01100,map00640,map01100	-	R00919	RC00095	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_962621_1	1122247.C731_0800	6e-19	84.3	COG4948@1|root,COG4948@2|Bacteria,2GJJR@201174|Actinobacteria,232UR@1762|Mycobacteriaceae	201174|Actinobacteria	H	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	GO:0008150,GO:0040007	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0553	MR_MLE_C
k59_1842973_1	1123033.ARNF01000088_gene1336	1.03e-27	107.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,1RMX5@1236|Gammaproteobacteria,3NKCS@468|Moraxellaceae	1236|Gammaproteobacteria	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	cobB	GO:0002252,GO:0002376,GO:0003674,GO:0003824,GO:0006464,GO:0006476,GO:0006807,GO:0006935,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018205,GO:0019213,GO:0019538,GO:0033558,GO:0034979,GO:0034983,GO:0035601,GO:0036048,GO:0036049,GO:0036055,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0071704,GO:0098542,GO:0098732,GO:0140096,GO:1901564	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k59_1842973_2	314345.SPV1_08281	5.78e-31	122.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria	1224|Proteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_903635_1	1458462.JNLK01000001_gene715	7.88e-09	62.0	COG1879@1|root,COG1879@2|Bacteria,1TRCS@1239|Firmicutes,24CWQ@186801|Clostridia,27T8S@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
k59_662310_1	1121106.JQKB01000015_gene5846	9.75e-104	323.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,2JPB3@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_1842985_1	1298593.TOL_0598	6.95e-55	182.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1XIZA@135619|Oceanospirillales	135619|Oceanospirillales	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_1079181_1	439235.Dalk_5090	2.33e-66	226.0	COG1018@1|root,COG1148@1|root,COG1018@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
k59_903646_1	1036674.A28LD_0319	1.42e-69	226.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,2QG67@267893|Idiomarinaceae	1236|Gammaproteobacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	budB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_720942_1	297246.lpp2333	1.82e-12	67.8	COG0711@1|root,COG0711@2|Bacteria,1R6C0@1224|Proteobacteria,1S4NA@1236|Gammaproteobacteria,1JCKA@118969|Legionellales	118969|Legionellales	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,OSCP
k59_720942_2	1283284.AZUK01000002_gene2799	4.67e-37	126.0	COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,1SA80@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_375406_1	1121937.AUHJ01000005_gene2209	3.5e-15	75.1	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,464GC@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	-	4.4.1.11	ko:K01761,ko:K10764	ko00270,ko00450,ko00920,ko01100,map00270,map00450,map00920,map01100	-	R00654,R01288,R04770	RC00020,RC00196,RC00348,RC01209,RC01210,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_375406_2	765912.Thimo_2643	9.53e-36	134.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1WWAI@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,Pribosyltran
k59_192684_1	571166.KI421509_gene3114	9.62e-44	152.0	COG0726@1|root,COG0726@2|Bacteria,1R5QW@1224|Proteobacteria,2TTV0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
k59_81840_1	268407.PWYN_27460	1.9e-19	87.0	COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,4HBMW@91061|Bacilli,26RSM@186822|Paenibacillaceae	91061|Bacilli	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_544289_1	243233.MCA3078	5.38e-06	50.1	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1T1HN@1236|Gammaproteobacteria,1XDWI@135618|Methylococcales	135618|Methylococcales	V	pfam abc	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_544289_2	243233.MCA3077	4.05e-99	296.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1XDJA@135618|Methylococcales	135618|Methylococcales	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_544290_1	66373.JOFQ01000007_gene3208	1.11e-56	188.0	COG0332@1|root,COG0332@2|Bacteria,2GJP8@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_426848_1	648757.Rvan_0462	3.91e-65	214.0	COG1752@1|root,COG1752@2|Bacteria,1R7RX@1224|Proteobacteria	1224|Proteobacteria	S	Esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_1843015_1	1121405.dsmv_0070	1.19e-116	348.0	COG1304@1|root,COG1304@2|Bacteria,1P72V@1224|Proteobacteria,42NSD@68525|delta/epsilon subdivisions,2WJRW@28221|Deltaproteobacteria,2MHNN@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Conserved region in glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
k59_1600446_1	439235.Dalk_0585	1.81e-50	181.0	COG0577@1|root,COG1340@1|root,COG2234@1|root,COG0577@2|Bacteria,COG1340@2|Bacteria,COG2234@2|Bacteria,1MVYE@1224|Proteobacteria,42PKN@68525|delta/epsilon subdivisions,2WIWP@28221|Deltaproteobacteria,2MIQI@213118|Desulfobacterales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,PA,Peptidase_M28
k59_1488217_1	313589.JNB_08889	1.34e-91	300.0	COG0110@1|root,COG1020@1|root,COG0110@2|Bacteria,COG1020@2|Bacteria,2I8TI@201174|Actinobacteria,4FE80@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Hexapep,PP-binding
k59_1190771_1	930169.B5T_00463	3.44e-20	85.1	COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,1S3PQ@1236|Gammaproteobacteria,1XIY0@135619|Oceanospirillales	135619|Oceanospirillales	L	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
k59_1843019_1	1035308.AQYY01000002_gene947	1.63e-52	176.0	COG0404@1|root,COG0404@2|Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine	-	-	1.5.99.5,2.1.2.10	ko:K00605,ko:K06980,ko:K22086	ko00260,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200	M00532	R00609,R01221,R02300,R04125	RC00022,RC00069,RC00183,RC00190,RC00557,RC02834	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	GCV_T,GCV_T_C
k59_1843019_2	1035308.AQYY01000002_gene946	1.88e-33	119.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1794
k59_1488221_1	1210046.B277_13869	8.3e-125	369.0	COG0174@1|root,COG0174@2|Bacteria,2GMN1@201174|Actinobacteria,4FEXR@85021|Intrasporangiaceae	201174|Actinobacteria	E	glutamine synthetase	glnA	GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_309536_1	96561.Dole_2840	1.26e-62	200.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,42NPG@68525|delta/epsilon subdivisions,2WJVP@28221|Deltaproteobacteria,2MI18@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
k59_259448_1	367299.JOEE01000005_gene3516	7.12e-99	319.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,2GN09@201174|Actinobacteria,4FFMF@85021|Intrasporangiaceae	201174|Actinobacteria	E	glutamate synthase	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1542147_1	399739.Pmen_0619	3.96e-08	60.8	COG0784@1|root,COG2199@1|root,COG2200@1|root,COG0784@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1YD18@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	ko:K21025	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg
k59_1718062_1	1194165.CAJF01000013_gene1263	8.9e-48	162.0	COG1309@1|root,COG1309@2|Bacteria,2IR68@201174|Actinobacteria,4FSCQ@85023|Microbacteriaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_375452_1	1380355.JNIJ01000017_gene4710	2.01e-99	297.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,2VEXI@28211|Alphaproteobacteria,3JRDI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_720970_1	1380370.JIBA01000013_gene1242	1.01e-20	90.9	COG5485@1|root,COG5485@2|Bacteria,2INMM@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
k59_81884_1	1049564.TevJSym_aj00430	4e-34	126.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1J4HG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_1843041_1	926550.CLDAP_24540	9.71e-34	122.0	COG2186@1|root,COG2186@2|Bacteria,2G8XU@200795|Chloroflexi	200795|Chloroflexi	K	FCD domain	-	-	-	-	-	-	-	-	-	-	-	-	FCD
k59_1843041_2	1128421.JAGA01000003_gene2821	1.04e-09	59.3	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2NPPN@2323|unclassified Bacteria	2|Bacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_259469_1	1255043.TVNIR_1504	5.01e-23	93.2	COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria,1SAW8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	dksA traR	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
k59_259469_2	463191.SSEG_08047	4.9e-06	48.1	COG3217@1|root,COG3217@2|Bacteria,2GPWY@201174|Actinobacteria	201174|Actinobacteria	S	MOSC domain protein beta barrel domain protein	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
k59_426876_1	1121406.JAEX01000005_gene2868	3.04e-69	224.0	COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,42NI3@68525|delta/epsilon subdivisions,2WJ6P@28221|Deltaproteobacteria,2M856@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_602781_1	292564.Cyagr_1269	1.89e-62	206.0	COG3177@1|root,COG3177@2|Bacteria	2|Bacteria	D	Filamentation induced by cAMP protein fic	XK27_00240	-	-	-	-	-	-	-	-	-	-	-	Fic,HTH_DeoR
k59_192729_1	754476.Q7A_2836	3.57e-121	357.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,4602K@72273|Thiotrichales	72273|Thiotrichales	D	TIGRFAM Cell shape determining protein MreB Mrl	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_1843064_1	1121405.dsmv_3355	1.21e-66	212.0	COG0642@1|root,COG2205@2|Bacteria,1RK25@1224|Proteobacteria,42T3D@68525|delta/epsilon subdivisions,2WMAT@28221|Deltaproteobacteria,2MI6G@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_662359_1	396588.Tgr7_0326	3.87e-13	65.1	COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,1S9B2@1236|Gammaproteobacteria,1WYI8@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
k59_662359_2	693977.Deipr_1894	2.18e-17	82.0	COG0801@1|root,COG0801@2|Bacteria,1WJU9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	TIGRFAM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
k59_662359_3	472759.Nhal_0029	9.79e-102	310.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,1RYCJ@1236|Gammaproteobacteria,1WWJG@135613|Chromatiales	135613|Chromatiales	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
k59_1488259_1	1499967.BAYZ01000003_gene5838	6.52e-88	275.0	COG4783@1|root,COG4783@2|Bacteria,2NP4F@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_16,TPR_19,TPR_2,TPR_8
k59_1843066_1	672.VV93_v1c05190	1.19e-11	69.7	COG1226@1|root,COG1226@2|Bacteria,1RBAK@1224|Proteobacteria,1S5SS@1236|Gammaproteobacteria,1XSZ1@135623|Vibrionales	135623|Vibrionales	P	COG1226 Kef-type K transport systems	VV0578	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,Ion_trans_2
k59_838075_1	598467.BrE312_3198	5.17e-53	179.0	COG1609@1|root,COG1609@2|Bacteria,1MXUS@1224|Proteobacteria,1RQFT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator	malI	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K02529,ko:K16136	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
k59_25660_1	1122194.AUHU01000008_gene3354	4.58e-16	84.3	COG3291@1|root,COG3291@2|Bacteria,1QWZ9@1224|Proteobacteria,1S0H3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Cellulase N-terminal ig-like domain	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CelD_N,Glyco_hydro_9
k59_602797_1	1249627.D779_2097	5.49e-75	234.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1WW0A@135613|Chromatiales	135613|Chromatiales	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1253363_1	757424.Hsero_3707	1.14e-107	318.0	COG0463@1|root,COG0463@2|Bacteria,1QTWH@1224|Proteobacteria,2VKU3@28216|Betaproteobacteria,472TW@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1253363_2	1163408.UU9_11570	2.19e-46	154.0	COG0824@1|root,COG0824@2|Bacteria,1RH6W@1224|Proteobacteria,1S6BU@1236|Gammaproteobacteria,1X6UW@135614|Xanthomonadales	135614|Xanthomonadales	S	Thioesterase superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
k59_1660680_1	1117315.AHCA01000021_gene4284	6.68e-19	86.7	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,2Q1CH@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_309579_1	485916.Dtox_4069	1.18e-27	108.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k59_962742_1	68170.KL590489_gene10275	0.00046	48.5	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	bprV	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Inhibitor_I9,Peptidase_S8
k59_962742_2	68886.XP_009691605.1	1.58e-05	47.0	COG4870@1|root,KOG1543@2759|Eukaryota,3YA1N@5794|Apicomplexa,3KC66@422676|Aconoidasida,3Z45K@5863|Piroplasmida	422676|Aconoidasida	O	Belongs to the peptidase C1 family	-	GO:0000323,GO:0003674,GO:0003824,GO:0004175,GO:0004197,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005773,GO:0005783,GO:0005794,GO:0006508,GO:0006807,GO:0007568,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0009893,GO:0009894,GO:0009896,GO:0010033,GO:0010604,GO:0012505,GO:0016787,GO:0019222,GO:0019538,GO:0019899,GO:0019902,GO:0030162,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0031404,GO:0032268,GO:0032270,GO:0032502,GO:0042176,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043621,GO:0044238,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045732,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051087,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1903050,GO:1903052,GO:1903362,GO:1903364	-	-	-	-	-	-	-	-	-	-	Inhibitor_I29,Peptidase_C1
k59_375506_1	1280952.HJA_13220	7.64e-212	601.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases	MA20_01050	-	1.17.1.10	ko:K15022	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00377	R00134	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3
k59_1129385_1	1358423.N180_19030	2.22e-38	142.0	COG3250@1|root,COG3250@2|Bacteria,4NHRV@976|Bacteroidetes,1IUSH@117747|Sphingobacteriia	976|Bacteroidetes	G	Glycosyl hydrolases family 2, TIM barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C
k59_1080337_2	523791.Kkor_1210	7.73e-26	106.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1XHS8@135619|Oceanospirillales	135619|Oceanospirillales	DM	COG3264 Small-conductance mechanosensitive channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM,MscS_porin
k59_260801_1	395493.BegalDRAFT_3436	1.54e-78	248.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_1254441_1	1035308.AQYY01000001_gene3150	8.15e-46	162.0	COG3288@1|root,COG3288@2|Bacteria,1UI27@1239|Firmicutes,25ETS@186801|Clostridia,267HW@186807|Peptococcaceae	186801|Clostridia	C	Alanine dehydrogenase/PNT, C-terminal domain	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_1254441_2	1454010.JEOE01000015_gene1140	1.93e-23	100.0	COG1282@1|root,COG1282@2|Bacteria,2GNKB@201174|Actinobacteria,4F0EA@85016|Cellulomonadaceae	201174|Actinobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_545070_1	1120963.KB894500_gene100	2.91e-58	197.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	oligopeptide transporter	-	-	-	-	-	-	-	-	-	-	-	-	OPT
k59_608958_1	933262.AXAM01000023_gene657	9.87e-68	220.0	COG0836@1|root,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,42MDP@68525|delta/epsilon subdivisions,2WJEN@28221|Deltaproteobacteria,2MIA7@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase	manAC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_269625_2	990285.RGCCGE502_03292	6.43e-12	68.6	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2TSGV@28211|Alphaproteobacteria,4B8MH@82115|Rhizobiaceae	28211|Alphaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0052116,GO:0052126,GO:0052127,GO:0052143,GO:0052192,GO:0052195,GO:0052216,GO:0052243	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
k59_971766_1	768671.ThimaDRAFT_2108	2.96e-71	227.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1RRXM@1236|Gammaproteobacteria,1WYGD@135613|Chromatiales	135613|Chromatiales	K	PFAM Bacterial regulatory helix-turn-helix proteins, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_1135145_1	2340.JV46_17000	1.24e-99	311.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1J4RW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA helicase	uvrD	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0042802,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1016775_2	1163617.SCD_n01160	4.64e-235	668.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Extracellular solute-binding protein	oppA	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
k59_1323936_1	1049564.TevJSym_ca00050	6.25e-151	458.0	COG1033@1|root,COG2834@1|root,COG1033@2|Bacteria,COG2834@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1J96Q@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	MMPL family	VP1286	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_1323936_2	1123393.KB891316_gene1127	2.74e-64	202.0	COG1416@1|root,COG1416@2|Bacteria,1RHW0@1224|Proteobacteria,2VWXN@28216|Betaproteobacteria,1KSFB@119069|Hydrogenophilales	119069|Hydrogenophilales	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
k59_726707_1	717785.HYPMC_0348	8.55e-93	280.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,2TTP3@28211|Alphaproteobacteria,3N71F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
k59_140009_1	1201293.AKXQ01000012_gene3980	2.75e-26	110.0	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
k59_1666908_1	1386089.N865_03880	2.06e-08	54.7	COG0101@1|root,COG0101@2|Bacteria,2GJ6C@201174|Actinobacteria,4FES4@85021|Intrasporangiaceae	201174|Actinobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_1666908_2	1370120.AUWR01000002_gene3591	3.21e-38	133.0	COG3801@1|root,COG3801@2|Bacteria,2IQGZ@201174|Actinobacteria,23FB3@1762|Mycobacteriaceae	201174|Actinobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
k59_844213_1	1156935.QWE_15032	8.84e-05	51.2	COG0471@1|root,COG0569@1|root,COG0471@2|Bacteria,COG0569@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria,4B7TF@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Di- and tricarboxylate transporters	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_1197023_1	396588.Tgr7_2226	3.65e-100	295.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1WW37@135613|Chromatiales	135613|Chromatiales	O	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
k59_1197023_2	519989.ECTPHS_02204	1.83e-12	70.1	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,1WW2G@135613|Chromatiales	135613|Chromatiales	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri,YfiO
k59_315920_1	1038866.KB902824_gene1250	1.73e-29	111.0	2CM31@1|root,32SD0@2|Bacteria,1N2TZ@1224|Proteobacteria,2UH7X@28211|Alphaproteobacteria,3K1PA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_315920_2	187272.Mlg_1406	2.56e-21	88.6	COG2227@1|root,COG2227@2|Bacteria,1QVH1@1224|Proteobacteria,1T2QF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
k59_1852246_1	933262.AXAM01000022_gene3227	4e-48	169.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42N2H@68525|delta/epsilon subdivisions,2WMIR@28221|Deltaproteobacteria,2MIIF@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase N terminal	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_608984_1	1499967.BAYZ01000152_gene1432	4.68e-70	219.0	COG1131@1|root,COG1131@2|Bacteria,2NPDQ@2323|unclassified Bacteria	2|Bacteria	V	ATPases associated with a variety of cellular activities	natA2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1323980_1	1122622.ATWJ01000013_gene104	5.54e-109	326.0	COG1819@1|root,COG1819@2|Bacteria,2HEXA@201174|Actinobacteria,4FFXB@85021|Intrasporangiaceae	201174|Actinobacteria	CG	UDP-glucoronosyl and UDP-glucosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	UDPGT
k59_971819_1	439235.Dalk_3317	2.1e-44	155.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJUN@28221|Deltaproteobacteria,2MIK6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1547995_1	1122137.AQXF01000004_gene1819	4.51e-37	137.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2TVZH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Mg2 and Co2 transporter CorB	corB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_1547995_2	1134912.AJTV01000033_gene2255	2.32e-08	56.6	COG0337@1|root,COG0703@1|root,COG0337@2|Bacteria,COG0703@2|Bacteria,1MUBK@1224|Proteobacteria,2TRDA@28211|Alphaproteobacteria,36XUV@31993|Methylocystaceae	28211|Alphaproteobacteria	E	3-dehydroquinate synthase	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
k59_1087102_1	1385935.N836_04960	6.46e-86	261.0	COG1738@1|root,COG1738@2|Bacteria,1G49U@1117|Cyanobacteria,1HEMD@1150|Oscillatoriales	1117|Cyanobacteria	U	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
k59_781896_1	1517416.IDAT_09495	2.19e-33	126.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,1RMMT@1236|Gammaproteobacteria,2QFBF@267893|Idiomarinaceae	1236|Gammaproteobacteria	M	Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate	mpl	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0042802,GO:0044424,GO:0044464	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	iSDY_1059.SDY_4251	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_781896_2	765912.Thimo_0062	1.23e-19	88.2	2952G@1|root,2ZSF9@2|Bacteria,1NFKJ@1224|Proteobacteria,1S5Q0@1236|Gammaproteobacteria,1WY9R@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1261306_1	314230.DSM3645_18396	5.91e-07	50.4	COG0297@1|root,COG0297@2|Bacteria,2IX7T@203682|Planctomycetes	203682|Planctomycetes	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_1261306_2	765914.ThisiDRAFT_1725	1.63e-61	201.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1WW77@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
k59_844243_1	439235.Dalk_0047	1.87e-39	145.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria,2MI8B@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_1548007_2	1007105.PT7_1390	9.13e-61	199.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2VHBR@28216|Betaproteobacteria,3T38Z@506|Alcaligenaceae	28216|Betaproteobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_198627_1	888050.HMPREF9004_1842	8.54e-109	325.0	COG1275@1|root,COG1275@2|Bacteria,2IA9G@201174|Actinobacteria	201174|Actinobacteria	P	C4-dicarboxylate transporter malic acid transport protein	-	-	-	ko:K03304	-	-	-	-	ko00000,ko02000	2.A.16.1	-	-	SLAC1
k59_971861_1	448385.sce5755	4.64e-07	48.5	COG1977@1|root,COG1977@2|Bacteria,1N15U@1224|Proteobacteria,42XSH@68525|delta/epsilon subdivisions,2WTDG@28221|Deltaproteobacteria,2Z1PX@29|Myxococcales	28221|Deltaproteobacteria	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
k59_971861_2	1469245.JFBG01000010_gene600	1.52e-125	378.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.17.1.9	ko:K00122	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_1372100_1	1122951.ATUE01000008_gene233	2.58e-40	150.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,3NIRS@468|Moraxellaceae	1236|Gammaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iEC042_1314.EC042_2346,iECUMN_1333.ECUMN_2446	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_1372100_2	1387312.BAUS01000002_gene290	9.73e-20	85.9	COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,2VN5I@28216|Betaproteobacteria,2KMT4@206350|Nitrosomonadales	206350|Nitrosomonadales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4_21
k59_609014_1	1267005.KB911259_gene3695	2.22e-73	233.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2TR70@28211|Alphaproteobacteria,3N6TI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_1852321_1	1040983.AXAE01000025_gene4655	1.48e-23	100.0	COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,2U9U2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_1548723_1	631362.Thi970DRAFT_04707	2.24e-81	250.0	COG1242@1|root,COG1242@2|Bacteria,1MUYF@1224|Proteobacteria,1RP94@1236|Gammaproteobacteria,1WWKB@135613|Chromatiales	135613|Chromatiales	S	PFAM Radical SAM	-	-	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
k59_37172_1	631362.Thi970DRAFT_04587	4.28e-58	187.0	COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,1S2B6@1236|Gammaproteobacteria,1X0E4@135613|Chromatiales	135613|Chromatiales	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_669000_1	330214.NIDE3251	2.46e-55	198.0	COG3696@1|root,COG3696@2|Bacteria	2|Bacteria	P	silver ion transport	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
k59_92454_1	572477.Alvin_1597	3.4e-61	199.0	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,1RQ50@1236|Gammaproteobacteria,1WWA9@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD dependent oxidoreductase	-	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
k59_385919_1	690850.Desaf_3634	5.92e-29	118.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,42MDX@68525|delta/epsilon subdivisions,2WJ56@28221|Deltaproteobacteria,2M86F@213115|Desulfovibrionales	28221|Deltaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
k59_385919_2	1117647.M5M_19315	3.75e-25	105.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,1J4RJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_37178_1	34506.g6059	4.09e-151	473.0	COG0481@1|root,COG0571@1|root,COG1159@1|root,KOG0462@2759|Eukaryota,KOG1423@2759|Eukaryota,KOG1817@2759|Eukaryota,38H35@33154|Opisthokonta,3BWUB@33208|Metazoa,3DDYP@33213|Bilateria,40QZN@6231|Nematoda,1M7YV@119089|Chromadorea,4172X@6236|Rhabditida	33208|Metazoa	J	GTP-binding protein LepA C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_914251_1	398580.Dshi_2295	4.3e-68	222.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_609792_1	1380347.JNII01000007_gene308	2.16e-81	261.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria,4ERPW@85013|Frankiales	201174|Actinobacteria	KOT	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
k59_1667705_1	1123256.KB907925_gene1511	6.39e-12	65.5	COG3784@1|root,COG3784@2|Bacteria,1MYIH@1224|Proteobacteria,1S8D2@1236|Gammaproteobacteria,1X61X@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1318
k59_1667705_2	1123256.KB907925_gene1512	3.94e-25	105.0	COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,1S3FX@1236|Gammaproteobacteria,1X466@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_92471_1	1122603.ATVI01000012_gene1154	3.63e-49	172.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,1X4F8@135614|Xanthomonadales	135614|Xanthomonadales	L	glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
k59_385930_1	1173020.Cha6605_6113	3.35e-41	147.0	COG0837@1|root,COG0837@2|Bacteria,1G1TJ@1117|Cyanobacteria	1117|Cyanobacteria	G	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
k59_1853740_1	357808.RoseRS_1668	6.31e-20	96.3	COG2518@1|root,COG4797@1|root,COG2518@2|Bacteria,COG4797@2|Bacteria	2|Bacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008757,GO:0016278,GO:0016740,GO:0016741,GO:0032259	2.1.1.163,2.1.1.201,2.1.1.77	ko:K00573,ko:K03183,ko:K07003	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF3560,MethyTransf_Reg,Methyltransf_12,Methyltransf_25,Methyltransf_31
k59_92477_1	1032480.MLP_37180	2.66e-62	209.0	COG2339@1|root,COG2339@2|Bacteria,2GKR5@201174|Actinobacteria,4DQ3Y@85009|Propionibacteriales	201174|Actinobacteria	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
k59_973280_1	58123.JOFJ01000043_gene79	8.11e-60	196.0	COG2801@1|root,COG2801@2|Bacteria,2GKDY@201174|Actinobacteria,4EJH2@85012|Streptosporangiales	201174|Actinobacteria	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_1372834_1	926550.CLDAP_27010	3.17e-37	140.0	COG1850@1|root,COG1850@2|Bacteria,2G8AG@200795|Chloroflexi	200795|Chloroflexi	G	Ribulose bisphosphate carboxylase large chain, catalytic domain	-	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large
k59_140802_1	96561.Dole_2335	4.01e-53	181.0	COG0745@1|root,COG0745@2|Bacteria,1NE8H@1224|Proteobacteria,42NEH@68525|delta/epsilon subdivisions,2WK1M@28221|Deltaproteobacteria,2MHU4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2,Response_reg
k59_1783208_1	153948.NAL212_3117	5.8e-159	483.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2VJSI@28216|Betaproteobacteria,372PZ@32003|Nitrosomonadales	28216|Betaproteobacteria	L	RNA polymerase recycling family C-terminal	-	-	-	ko:K03580	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	DUF3883,Helicase_C,RapA_C,ResIII,SNF2_N
k59_1783208_2	1266914.ATUK01000011_gene2415	3.25e-63	199.0	COG1416@1|root,COG1416@2|Bacteria,1MZ46@1224|Proteobacteria,1SNE5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DsrE/DsrF-like family	-	-	-	ko:K09004	-	-	-	-	ko00000	-	-	-	DrsE
k59_92507_1	243233.MCA0662	2.64e-84	262.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1XDS3@135618|Methylococcales	135618|Methylococcales	S	AI-2E family transporter	-	-	-	ko:K03548	-	-	-	-	ko00000,ko02000	2.A.86.1	-	-	AI-2E_transport
k59_92507_2	435908.IDSA_11305	3.99e-11	60.8	COG0607@1|root,COG0607@2|Bacteria,1MZFN@1224|Proteobacteria,1S9M6@1236|Gammaproteobacteria,2QG8P@267893|Idiomarinaceae	1236|Gammaproteobacteria	P	Sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1548760_1	1123502.AQXD01000001_gene782	1.35e-19	93.2	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1XCFD@135614|Xanthomonadales	135614|Xanthomonadales	M	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
k59_1088038_1	319003.Bra1253DRAFT_04526	2.39e-35	136.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2TRKK@28211|Alphaproteobacteria,3JSMB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Mechanosensitive ion channel	MA20_40450	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_973311_1	886377.Murru_0789	3.46e-16	78.2	COG5061@1|root,COG5061@2|Bacteria,4NJWC@976|Bacteroidetes,1HXKF@117743|Flavobacteriia	976|Bacteroidetes	OU	Protein of unknown function (DUF3307)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3307
k59_1725159_1	366649.XFF4834R_chr06400	2.44e-55	192.0	COG1770@1|root,COG1770@2|Bacteria,1MUED@1224|Proteobacteria,1RMSV@1236|Gammaproteobacteria,1X31I@135614|Xanthomonadales	135614|Xanthomonadales	E	peptidase	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_199385_1	472759.Nhal_2211	9.87e-24	101.0	COG1184@1|root,COG1184@2|Bacteria,1R0HY@1224|Proteobacteria,1T4I6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Initiation factor 2 subunit family	-	-	-	ko:K03680	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	IF-2B
k59_316757_1	765910.MARPU_15720	1.43e-56	191.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1WXE8@135613|Chromatiales	135613|Chromatiales	S	PFAM Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_845030_1	335543.Sfum_1583	1.75e-30	115.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,42SBD@68525|delta/epsilon subdivisions,2WP9P@28221|Deltaproteobacteria,2MQIR@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	PFAM ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
k59_1088066_1	1139219.I569_02040	3.92e-10	62.4	COG0627@1|root,COG0627@2|Bacteria,1TPA9@1239|Firmicutes,4HD64@91061|Bacilli,4B0RH@81852|Enterococcaceae	91061|Bacilli	S	Putative esterase	estA	-	-	ko:K03930	-	-	-	-	ko00000,ko01000	-	CE1	-	Esterase
k59_1197852_1	765912.Thimo_2557	2.51e-73	234.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1WVVC@135613|Chromatiales	135613|Chromatiales	F	TIGRFAM dihydroorotase, multifunctional complex type	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_1432890_1	765912.Thimo_3262	1.19e-87	266.0	COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria,1WVWS@135613|Chromatiales	135613|Chromatiales	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	apaH	-	3.6.1.41	ko:K01525	ko00230,map00230	-	R00125	RC00002	ko00000,ko00001,ko01000	-	-	-	Metallophos
k59_1432890_2	1283300.ATXB01000001_gene211	5.28e-25	99.8	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,1S5VH@1236|Gammaproteobacteria,1XF82@135618|Methylococcales	135618|Methylococcales	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	-	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
k59_492597_1	269799.Gmet_0951	1.73e-92	298.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,43UIT@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1325560_1	177437.HRM2_07810	6.77e-23	93.2	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_551171_1	196490.AUEZ01000002_gene4326	8.04e-124	370.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,3JUVV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Flavin containing amine oxidoreductase	MA20_01895	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_140845_1	765911.Thivi_0295	1.29e-68	222.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria,1WWCF@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3329,HATPase_c,HisKA,PAS,PAS_8
k59_1262220_1	590998.Celf_1587	1.3e-99	295.0	COG1974@1|root,COG1974@2|Bacteria,2GMBN@201174|Actinobacteria,4F0QQ@85016|Cellulomonadaceae	201174|Actinobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0042221,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_845043_2	1469613.JT55_02565	0.000713	45.1	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2TTE8@28211|Alphaproteobacteria,3FCGJ@34008|Rhodovulum	28211|Alphaproteobacteria	D	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_1017540_1	743720.Psefu_3624	5.17e-90	277.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1YWSQ@136845|Pseudomonas putida group	1236|Gammaproteobacteria	M	lytic murein transglycosylase B	mltB	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
k59_1667765_1	717785.HYPMC_0313	5.46e-77	236.0	COG1309@1|root,COG1309@2|Bacteria,1MUUY@1224|Proteobacteria,2TUIH@28211|Alphaproteobacteria,3N95K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	WHG domain	MA20_04045	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
k59_1725188_1	936548.HMPREF1136_0652	2.16e-06	48.9	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4D3IX@85005|Actinomycetales	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_1725188_2	446466.Cfla_2063	1.06e-71	230.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2IBV1@201174|Actinobacteria	201174|Actinobacteria	M	lytic transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	LysM,SLT
k59_1606939_4	882.DVU_1121	1.56e-14	75.1	2A46W@1|root,30SS3@2|Bacteria,1PC54@1224|Proteobacteria,4324M@68525|delta/epsilon subdivisions,2WXP6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	tRNA_anti-like	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_anti-like
k59_782647_1	396588.Tgr7_2153	2.72e-10	60.1	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1WWU2@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1787721_1	1123261.AXDW01000005_gene2606	5.92e-41	140.0	COG0454@1|root,COG0456@2|Bacteria,1QUS0@1224|Proteobacteria,1T4J2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1787721_2	1056816.JAFQ01000004_gene1224	3.74e-23	96.7	COG1280@1|root,COG1280@2|Bacteria,2GMDP@201174|Actinobacteria,4FVQB@85025|Nocardiaceae	201174|Actinobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
k59_1378025_1	313589.JNB_00225	2.78e-24	103.0	COG3591@1|root,COG4249@1|root,COG3591@2|Bacteria,COG4249@2|Bacteria,2IN77@201174|Actinobacteria,4FI7M@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the peptidase S1B family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
k59_923650_1	765914.ThisiDRAFT_2315	4.08e-174	527.0	COG0187@1|root,COG1372@1|root,COG0187@2|Bacteria,COG1372@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1WVZ4@135613|Chromatiales	135613|Chromatiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_1502551_1	1049564.TevJSym_au00470	5.25e-17	77.8	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1J54F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Catabolite gene activator and regulatory subunit of cAMP-dependent protein	anr	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_1502551_2	765912.Thimo_1320	2.41e-05	48.9	2BTT6@1|root,32P0R@2|Bacteria,1RKJP@1224|Proteobacteria,1S6ZB@1236|Gammaproteobacteria,1WYHA@135613|Chromatiales	135613|Chromatiales	S	Sulphur globule protein	-	-	-	-	-	-	-	-	-	-	-	-	SGP
k59_1021906_1	570967.JMLV01000018_gene483	3.56e-99	309.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2TRND@28211|Alphaproteobacteria,2JPUS@204441|Rhodospirillales	204441|Rhodospirillales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1203084_2	880072.Desac_2321	3.4e-33	125.0	COG0664@1|root,COG2259@1|root,COG2897@1|root,COG0664@2|Bacteria,COG2259@2|Bacteria,COG2897@2|Bacteria,1PDIN@1224|Proteobacteria,437BC@68525|delta/epsilon subdivisions,2X2G8@28221|Deltaproteobacteria,2MRZR@213462|Syntrophobacterales	28221|Deltaproteobacteria	PT	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,cNMP_binding
k59_982742_1	411477.PARMER_03655	4.13e-86	283.0	COG3250@1|root,COG3250@2|Bacteria,4NIBS@976|Bacteroidetes,2FPZ2@200643|Bacteroidia,22ZBT@171551|Porphyromonadaceae	976|Bacteroidetes	G	alpha-L-rhamnosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
k59_277724_1	1449063.JMLS01000027_gene79	3.46e-07	50.1	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	uidB	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
k59_615119_1	398580.Dshi_2820	0.000388	47.8	COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	response regulator containing a CheY-like receiver domain and a GGDEF domain	pleD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,Response_reg
k59_615119_2	1122622.ATWJ01000011_gene2340	2.14e-48	156.0	COG5207@1|root,COG5207@2|Bacteria	2|Bacteria	O	Pfam Zn-finger in ubiquitin-hydrolases and other protein	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N,zf-UBP
k59_1203091_1	43989.cce_4307	5.33e-69	229.0	COG2373@1|root,COG2373@2|Bacteria,1GQ3G@1117|Cyanobacteria	1117|Cyanobacteria	P	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase
k59_44720_1	933262.AXAM01000048_gene2591	7.65e-55	193.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2WITS@28221|Deltaproteobacteria,2MIFX@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,PurS
k59_322082_1	446466.Cfla_1403	3.77e-102	322.0	COG0525@1|root,COG0525@2|Bacteria,2GK8H@201174|Actinobacteria,4F0W1@85016|Cellulomonadaceae	201174|Actinobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_1787741_1	1499967.BAYZ01000083_gene1026	2.23e-37	135.0	COG3599@1|root,COG3599@2|Bacteria	2|Bacteria	D	regulation of cell shape	-	-	-	ko:K04074,ko:K07484	-	-	-	-	ko00000,ko03036	-	-	-	DDE_Tnp_IS66,DivIVA,zf-IS66
k59_1334974_1	1380387.JADM01000002_gene1873	2.47e-35	127.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,1XH39@135619|Oceanospirillales	135619|Oceanospirillales	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
k59_1334974_2	713586.KB900536_gene1456	1.04e-41	145.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,1RPZ3@1236|Gammaproteobacteria,1WZFI@135613|Chromatiales	135613|Chromatiales	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
k59_982773_1	1349820.M707_14340	1.42e-37	146.0	COG0728@1|root,COG0728@2|Bacteria,2GKN0@201174|Actinobacteria,1W83Z@1268|Micrococcaceae	201174|Actinobacteria	S	Integral membrane protein MviN	mviN	GO:0003674,GO:0005215,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_733057_1	935839.JAGJ01000007_gene3135	2.18e-76	236.0	COG0289@1|root,COG0289@2|Bacteria,2GM2T@201174|Actinobacteria,4F3QX@85017|Promicromonosporaceae	201174|Actinobacteria	E	Dihydrodipicolinate reductase, C-terminus	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
k59_1553980_1	768671.ThimaDRAFT_4705	7.99e-63	210.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria,1WWCP@135613|Chromatiales	135613|Chromatiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_1612163_1	396588.Tgr7_0774	1.7e-99	300.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1WVUV@135613|Chromatiales	135613|Chromatiales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_733059_1	589865.DaAHT2_0580	4.39e-57	194.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,42P0N@68525|delta/epsilon subdivisions,2WKQ0@28221|Deltaproteobacteria,2MJJ2@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
k59_204830_1	1453501.JELR01000001_gene2483	1.14e-80	245.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria,4648J@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_787078_1	471853.Bcav_2253	9.42e-113	337.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria	201174|Actinobacteria	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_787078_2	1304865.JAGF01000001_gene3583	6.13e-22	87.0	2EGVE@1|root,33AMN@2|Bacteria,2GQWM@201174|Actinobacteria,4F1HN@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_497968_1	314278.NB231_16013	1.61e-28	115.0	2BFY8@1|root,329TX@2|Bacteria,1R582@1224|Proteobacteria,1RY97@1236|Gammaproteobacteria,1WXMV@135613|Chromatiales	135613|Chromatiales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
k59_1673137_1	697282.Mettu_3004	1.09e-76	242.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1XE02@135618|Methylococcales	135618|Methylococcales	M	TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_204832_1	326297.Sama_0497	5.13e-35	130.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,2QA7Z@267890|Shewanellaceae	1236|Gammaproteobacteria	J	PFAM beta-lactamase domain protein	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL
k59_204832_2	223926.28806209	7.3e-13	67.8	COG2863@1|root,COG2863@2|Bacteria,1R8K9@1224|Proteobacteria,1S1Q4@1236|Gammaproteobacteria,1XX4A@135623|Vibrionales	135623|Vibrionales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K17230	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001	-	-	-	Cytochrome_CBB3
k59_1502591_1	768066.HELO_4438	9.96e-44	152.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,1RQQT@1236|Gammaproteobacteria,1XH3U@135619|Oceanospirillales	135619|Oceanospirillales	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
k59_1502591_2	1163409.UUA_00070	4.79e-38	140.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,1RYCJ@1236|Gammaproteobacteria,1X3YI@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
k59_146270_1	1049564.TevJSym_ah00950	1.42e-67	224.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1J54K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdZ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_1673138_1	335543.Sfum_2118	3.29e-100	308.0	COG0539@1|root,COG1093@1|root,COG0539@2|Bacteria,COG1093@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2MR1P@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_1021942_1	1095767.CAHD01000005_gene2438	3.4e-83	263.0	COG0477@1|root,COG0477@2|Bacteria,2I2Q2@201174|Actinobacteria,4F0N0@85016|Cellulomonadaceae	201174|Actinobacteria	EGP	TIGRFAM drug resistance transporter, Bcr CflA subfamily	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_1203120_2	1123401.JHYQ01000017_gene2512	3.68e-43	149.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,46069@72273|Thiotrichales	72273|Thiotrichales	E	Belongs to the TrpC family	trpC	-	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PRAI
k59_733075_1	880072.Desac_2371	5.15e-18	80.9	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NTG@68525|delta/epsilon subdivisions,2WKHW@28221|Deltaproteobacteria,2MQ9V@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_733075_2	880072.Desac_2370	3.38e-32	123.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MG3@68525|delta/epsilon subdivisions,2WKC7@28221|Deltaproteobacteria,2MQ7Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	COGs COG0767 ABC-type transport system involved in resistance to organic solvents permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_982806_1	443143.GM18_2915	1.42e-129	396.0	COG0553@1|root,COG0553@2|Bacteria,1MX26@1224|Proteobacteria,42P4C@68525|delta/epsilon subdivisions,2WKB5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KL	PFAM helicase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,ResIII
k59_1378088_1	1167006.UWK_03514	4.03e-75	241.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,42NA6@68525|delta/epsilon subdivisions,2WIMU@28221|Deltaproteobacteria,2MJ6H@213118|Desulfobacterales	28221|Deltaproteobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_1730549_1	323097.Nham_0084	2.75e-154	446.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,3JQXC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Ammonium Transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_733084_1	545264.KB898754_gene1799	4.12e-05	45.1	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,1RQJ7@1236|Gammaproteobacteria,1WXHF@135613|Chromatiales	135613|Chromatiales	Q	PFAM isochorismatase hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_733084_2	472759.Nhal_2223	1.84e-86	268.0	COG0591@1|root,COG0591@2|Bacteria,1N8H2@1224|Proteobacteria,1RR54@1236|Gammaproteobacteria,1X0GD@135613|Chromatiales	135613|Chromatiales	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_982819_1	522306.CAP2UW1_0296	2.45e-40	145.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,1KQNW@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
k59_982819_2	248742.XP_005648993.1	1.93e-05	47.8	COG0365@1|root,KOG1175@2759|Eukaryota,37PDE@33090|Viridiplantae	33090|Viridiplantae	I	Acetyl-coenzyme A synthetase	ACS	GO:0003674,GO:0003824,GO:0003987,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005829,GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009507,GO:0009514,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0071704	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iRC1080.CRv4_Au5_s7_g14502_t1	ACAS_N,AMP-binding,AMP-binding_C
k59_1335026_1	1123279.ATUS01000001_gene1340	1.4e-72	231.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RZVB@1236|Gammaproteobacteria,1J8DI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1960 Acyl-CoA dehydrogenases	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1140513_1	631362.Thi970DRAFT_02067	9.92e-127	394.0	COG0504@1|root,COG2244@1|root,COG0504@2|Bacteria,COG2244@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1WWJ8@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_395318_1	497964.CfE428DRAFT_5596	3.55e-93	303.0	COG0085@1|root,COG0085@2|Bacteria,46S8Q@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1673165_1	240016.ABIZ01000001_gene4856	2.44e-58	199.0	COG1199@1|root,COG1199@2|Bacteria,46SCS@74201|Verrucomicrobia,2ITJT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	HELICc2	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
k59_982841_1	1123070.KB899255_gene1340	3.93e-81	257.0	COG1502@1|root,COG1502@2|Bacteria,46SV9@74201|Verrucomicrobia,2IV54@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2,PLDc_N
k59_1863344_1	292415.Tbd_2201	3.67e-117	348.0	COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,2VKGG@28216|Betaproteobacteria,1KSI6@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_923771_1	709797.CSIRO_3139	2.24e-27	105.0	COG3686@1|root,COG3686@2|Bacteria,1RAEH@1224|Proteobacteria,2U5JJ@28211|Alphaproteobacteria,3JY5A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MAPEG family	MA20_30600	-	-	-	-	-	-	-	-	-	-	-	MAPEG
k59_615179_1	591158.SSMG_02012	2.97e-48	174.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,2GM65@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016853,GO:0016866,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0047727,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	5.4.99.13,5.4.99.2	ko:K01848,ko:K11942	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_923772_1	500153.JOEK01000014_gene5768	2.99e-53	179.0	COG1496@1|root,COG1496@2|Bacteria,2GN1M@201174|Actinobacteria	201174|Actinobacteria	Q	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
k59_923772_2	446471.Xcel_1287	3.39e-38	142.0	COG0206@1|root,COG0206@2|Bacteria,2GJWC@201174|Actinobacteria,4F3UR@85017|Promicromonosporaceae	201174|Actinobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_1863350_1	29581.BW37_02419	4.24e-55	194.0	COG3325@1|root,COG3979@1|root,COG3325@2|Bacteria,COG3979@2|Bacteria,1MWAR@1224|Proteobacteria,2VPQW@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Glyco_18	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	CBM_5_12,Glyco_hydro_18
k59_1502622_1	2340.JV46_14280	2.41e-106	322.0	COG1156@1|root,COG1156@2|Bacteria,1QUQE@1224|Proteobacteria,1T210@1236|Gammaproteobacteria,1JC0C@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_ab
k59_1335066_1	713586.KB900536_gene2290	2.42e-149	427.0	COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria,1WZWK@135613|Chromatiales	135613|Chromatiales	G	pfkB family carbohydrate kinase	-	-	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_1335066_2	489825.LYNGBM3L_16050	2.11e-11	66.2	COG0500@1|root,COG2226@2|Bacteria,1G5DI@1117|Cyanobacteria,1HER0@1150|Oscillatoriales	1117|Cyanobacteria	H	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31,Ubie_methyltran
k59_1730579_1	1279017.AQYJ01000029_gene3354	9.84e-43	156.0	COG3203@1|root,COG3203@2|Bacteria	2|Bacteria	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	ko:K09476	ko01501,ko02020,map01501,map02020	M00746	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.1.1.1	-	-	Porin_4
k59_787117_2	686340.Metal_0230	1.54e-28	106.0	COG1993@1|root,COG1993@2|Bacteria,1N8TP@1224|Proteobacteria,1SDYH@1236|Gammaproteobacteria,1XFJY@135618|Methylococcales	135618|Methylococcales	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
k59_395339_1	685778.AORL01000022_gene1456	2.93e-20	92.4	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2TSRZ@28211|Alphaproteobacteria,2K052@204457|Sphingomonadales	204457|Sphingomonadales	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_1730585_1	1123400.KB904791_gene60	2.95e-54	176.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,45ZWN@72273|Thiotrichales	72273|Thiotrichales	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1021983_1	1121405.dsmv_3267	2.84e-90	281.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MISJ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	ribonuclease Rne Rng family	cafA	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_1203168_2	1304284.L21TH_2298	5.84e-13	70.5	COG1762@1|root,COG1762@2|Bacteria,1VA2N@1239|Firmicutes,25BW3@186801|Clostridia	186801|Clostridia	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	2.7.1.202	ko:K02768	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
k59_1554051_1	649638.Trad_1713	9.77e-08	54.7	COG1070@1|root,COG1070@2|Bacteria,1WJ9Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.5	ko:K00848	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R03014	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
k59_1554051_2	1492737.FEM08_13090	2.5e-40	136.0	COG3254@1|root,COG3254@2|Bacteria,4NSEM@976|Bacteroidetes,1I4MI@117743|Flavobacteriia,2NWX6@237|Flavobacterium	976|Bacteroidetes	G	Involved in the anomeric conversion of L-rhamnose	-	-	5.1.3.32	ko:K03534	-	-	R10819	RC00563	ko00000,ko01000	-	-	-	rhaM
k59_146322_1	631362.Thi970DRAFT_01389	1.48e-212	593.0	COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,1RSIM@1236|Gammaproteobacteria,1WW7Y@135613|Chromatiales	135613|Chromatiales	C	reductase, dissimilatory-type alpha subunit	-	-	1.8.99.5	ko:K11180	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_923813_1	933262.AXAM01000022_gene3229	1.74e-63	209.0	COG1333@1|root,COG1333@2|Bacteria,1N6XE@1224|Proteobacteria,42NBB@68525|delta/epsilon subdivisions,2WIMD@28221|Deltaproteobacteria,2MIEB@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM ResB family protein	-	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
k59_44825_1	583355.Caka_2608	3.19e-75	233.0	COG2326@1|root,COG2326@2|Bacteria,46SAH@74201|Verrucomicrobia,3K801@414999|Opitutae	414999|Opitutae	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
k59_1093992_1	593907.Celgi_2613	2.72e-93	290.0	COG1328@1|root,COG1328@2|Bacteria,2GMGA@201174|Actinobacteria	201174|Actinobacteria	F	Ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
k59_1093993_1	367336.OM2255_06085	2.63e-44	161.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0471 Di- and tricarboxylate transporters	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_1203180_2	117187.FVEG_02992T0	9.11e-40	149.0	COG0476@1|root,COG2131@1|root,KOG2337@2759|Eukaryota,KOG3127@2759|Eukaryota,38CKP@33154|Opisthokonta,3NW0M@4751|Fungi,3QPY1@4890|Ascomycota,213M2@147550|Sordariomycetes,3TH9W@5125|Hypocreales,1FQU0@110618|Nectriaceae	4751|Fungi	H	to APG12 activating enzyme ApgG	ATG7	GO:0000045,GO:0000407,GO:0000422,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0006464,GO:0006497,GO:0006501,GO:0006807,GO:0006914,GO:0006950,GO:0006995,GO:0006996,GO:0007005,GO:0007033,GO:0007154,GO:0008104,GO:0008150,GO:0008152,GO:0008641,GO:0009056,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016236,GO:0016237,GO:0016740,GO:0016874,GO:0016877,GO:0018410,GO:0019538,GO:0019778,GO:0019779,GO:0022411,GO:0022607,GO:0031667,GO:0031668,GO:0031669,GO:0032258,GO:0032446,GO:0033036,GO:0033365,GO:0033554,GO:0034613,GO:0034645,GO:0034727,GO:0036211,GO:0042157,GO:0042158,GO:0042594,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043562,GO:0043687,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044804,GO:0044805,GO:0050896,GO:0051179,GO:0051641,GO:0051716,GO:0061726,GO:0061919,GO:0070647,GO:0070727,GO:0070925,GO:0071496,GO:0071704,GO:0071840,GO:0072665,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1905037	3.5.4.12	ko:K01493,ko:K08337	ko00240,ko01100,ko04136,ko04138,ko04140,ko04216,map00240,map01100,map04136,map04138,map04140,map04216	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044,ko03029,ko04121,ko04131	-	-	-	ATG7_N,ThiF
k59_556585_1	526225.Gobs_3761	2.21e-121	360.0	COG3177@1|root,COG3177@2|Bacteria,2GN3K@201174|Actinobacteria,4EUS7@85013|Frankiales	201174|Actinobacteria	S	filamentation induced by cAMP protein Fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N
k59_557235_1	545264.KB898752_gene2362	2.85e-33	118.0	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1WYHD@135613|Chromatiales	135613|Chromatiales	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
k59_1503303_1	404589.Anae109_1281	2.08e-51	184.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,2YWE3@29|Myxococcales	28221|Deltaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL-1	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
k59_1864577_1	1249627.D779_0951	1.16e-48	167.0	COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,1S6X3@1236|Gammaproteobacteria,1WWFD@135613|Chromatiales	135613|Chromatiales	K	PFAM Cyclic nucleotide-binding	-	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_283686_1	888052.HMPREF9006_0810	4.65e-39	143.0	COG2865@1|root,COG2865@2|Bacteria,2IFGR@201174|Actinobacteria,4D4K6@85005|Actinomycetales	201174|Actinobacteria	K	Putative DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AlbA_2
k59_1144246_1	1448860.BBJO01000026_gene147	6.6e-06	50.8	COG1797@1|root,arCOG00106@2157|Archaea,2XTIE@28890|Euryarchaeota,23T33@183963|Halobacteria	183963|Halobacteria	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,CbiA,GATase_3
k59_1144246_2	713587.THITH_12045	8.5e-15	69.7	COG0316@1|root,COG0316@2|Bacteria,1RKPC@1224|Proteobacteria,1SB76@1236|Gammaproteobacteria,1WYKT@135613|Chromatiales	135613|Chromatiales	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
k59_1558328_2	1509405.GV67_24775	1.45e-75	237.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2TTN2@28211|Alphaproteobacteria,4B77X@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	urtC	-	-	ko:K11961	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
k59_209196_1	1453500.AT05_10045	4.48e-155	453.0	COG4147@1|root,COG4147@2|Bacteria,4NHPT@976|Bacteroidetes,1HXQN@117743|Flavobacteriia	976|Bacteroidetes	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	actP	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_51001_1	83406.HDN1F_19250	9.84e-08	54.7	COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,1RZ41@1236|Gammaproteobacteria,1J6SD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2199 FOG GGDEF domain	pleD	-	2.7.7.65	ko:K13590	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF
k59_51001_2	1049564.TevJSym_ag00460	9.83e-124	357.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria,1J6IW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	HAD-hyrolase-like	gph	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0031404,GO:0033554,GO:0034641,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	iSBO_1134.SBO_3372,iSbBS512_1146.SbBS512_E3762,iYL1228.KPN_03756	HAD_2
k59_326410_1	367299.JOEE01000005_gene3524	2.49e-214	617.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4FEBK@85021|Intrasporangiaceae	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1207351_1	590998.Celf_3209	4.95e-82	253.0	COG0451@1|root,COG0451@2|Bacteria,2GMHH@201174|Actinobacteria	201174|Actinobacteria	M	3-beta hydroxysteroid dehydrogenase isomerase	-	GO:0000166,GO:0003674,GO:0003824,GO:0003854,GO:0004769,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0016020,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0016853,GO:0016860,GO:0016863,GO:0030283,GO:0033764,GO:0036094,GO:0043167,GO:0043168,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901360,GO:1901363	1.1.1.145,1.1.1.412,5.3.3.1	ko:K16045,ko:K22320	ko00984,ko01120,map00984,map01120	-	R09920	RC00146	ko00000,ko00001,ko01000	-	-	-	3Beta_HSD,Epimerase
k59_1870430_1	1121028.ARQE01000001_gene3597	2.96e-13	76.3	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria,2PJBD@255475|Aurantimonadaceae	28211|Alphaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_790584_1	1210046.B277_00160	3.66e-65	215.0	COG4166@1|root,COG4166@2|Bacteria,2GIUH@201174|Actinobacteria,4FE56@85021|Intrasporangiaceae	201174|Actinobacteria	E	Peptide ABC transporter substrate-binding protein	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
k59_209203_1	1035308.AQYY01000001_gene3035	2.65e-53	180.0	COG2378@1|root,COG2378@2|Bacteria	2|Bacteria	K	regulation of single-species biofilm formation	pafC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
k59_402421_1	380358.XALC_1761	1e-72	251.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1X46R@135614|Xanthomonadales	135614|Xanthomonadales	E	glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH,GDH_N
k59_283705_1	177437.HRM2_27590	1.86e-146	426.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,42M48@68525|delta/epsilon subdivisions,2WISV@28221|Deltaproteobacteria,2MIBH@213118|Desulfobacterales	28221|Deltaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_679029_1	1454004.AW11_01126	1.93e-100	304.0	COG0056@1|root,COG0056@2|Bacteria,1MVHM@1224|Proteobacteria,2VPGJ@28216|Betaproteobacteria,1KR74@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	ATP synthase alpha/beta chain, C terminal domain	atpA2	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_1442554_1	1298593.TOL_3103	6.17e-84	260.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1XIUA@135619|Oceanospirillales	135619|Oceanospirillales	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
k59_1677522_2	909663.KI867150_gene2533	3.01e-40	142.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2WJW8@28221|Deltaproteobacteria,2MQBF@213462|Syntrophobacterales	28221|Deltaproteobacteria	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
k59_108911_1	1158146.KB907125_gene2409	3.81e-14	67.4	COG3668@1|root,COG3668@2|Bacteria	2|Bacteria	D	Plasmid stabilization system	Z012_02510	-	-	ko:K19092	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
k59_990007_1	1122599.AUGR01000027_gene1289	2.62e-43	144.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,1XK2F@135619|Oceanospirillales	135619|Oceanospirillales	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
k59_990007_2	572477.Alvin_0915	2.81e-28	111.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1WWZ0@135613|Chromatiales	135613|Chromatiales	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_1870446_1	316067.Geob_3631	1.1e-75	255.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1207367_1	768671.ThimaDRAFT_3635	2.28e-62	195.0	2C3ZQ@1|root,32SCF@2|Bacteria,1N27R@1224|Proteobacteria,1S4HC@1236|Gammaproteobacteria,1X16N@135613|Chromatiales	135613|Chromatiales	S	MEKHLA domain	-	-	-	-	-	-	-	-	-	-	-	-	MEKHLA
k59_990017_1	1316936.K678_08559	1.3e-36	141.0	COG1165@1|root,COG1165@2|Bacteria,1MVMZ@1224|Proteobacteria,2UNMH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_M_2,TPP_enzyme_N
k59_1025520_1	471853.Bcav_2149	1.74e-74	238.0	COG0204@1|root,COG0204@2|Bacteria,2GP8A@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_679044_1	1122933.JNIY01000010_gene1305	1.44e-96	301.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4F1TN@85016|Cellulomonadaceae	201174|Actinobacteria	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_51043_2	381666.H16_A1394	4.32e-81	249.0	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,2VPQ0@28216|Betaproteobacteria,1K6KX@119060|Burkholderiaceae	28216|Betaproteobacteria	E	ornithine cyclodeaminase	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
k59_560784_1	768671.ThimaDRAFT_0815	3.18e-66	220.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,1WXVP@135613|Chromatiales	135613|Chromatiales	P	PFAM von Willebrand factor type A	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_2
k59_1382599_1	243233.MCA1539	1.32e-69	229.0	COG2304@1|root,COG2304@2|Bacteria,1PBVT@1224|Proteobacteria,1RSKK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	von willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_679050_1	1095767.CAHD01000100_gene1498	2.95e-11	68.2	COG4339@1|root,COG4339@2|Bacteria,2GMYQ@201174|Actinobacteria,4F0MK@85016|Cellulomonadaceae	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_402467_1	471853.Bcav_3234	4.1e-71	231.0	COG0265@1|root,COG3115@1|root,COG0265@2|Bacteria,COG3115@2|Bacteria,2GJ96@201174|Actinobacteria	201174|Actinobacteria	O	Peptidase s1 and s6 chymotrypsin hap	degP	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
k59_1507573_1	1249627.D779_1891	4.9e-78	254.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1WXD9@135613|Chromatiales	135613|Chromatiales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_283752_2	1254432.SCE1572_47340	6.97e-56	187.0	COG0520@1|root,COG0520@2|Bacteria,1MXH1@1224|Proteobacteria,43203@68525|delta/epsilon subdivisions,2WWMI@28221|Deltaproteobacteria,2YTY1@29|Myxococcales	28221|Deltaproteobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	cefD	-	5.1.1.17	ko:K04127	ko00311,ko01100,ko01130,map00311,map01100,map01130	M00673	R04147	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
k59_1734799_2	471853.Bcav_2174	5.95e-149	426.0	COG1660@1|root,COG1660@2|Bacteria,2GMWB@201174|Actinobacteria	201174|Actinobacteria	S	Displays ATPase and GTPase activities	yvcJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
k59_1734801_1	1095767.CAHD01000231_gene2896	1.25e-130	378.0	COG2141@1|root,COG2141@2|Bacteria,2GM94@201174|Actinobacteria,4F1T9@85016|Cellulomonadaceae	201174|Actinobacteria	C	TIGRFAM F420-dependent oxidoreductase, G6PDH family	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_51074_1	710696.Intca_0704	3.14e-30	119.0	COG0282@1|root,COG0282@2|Bacteria,2GJAW@201174|Actinobacteria,4FEVN@85021|Intrasporangiaceae	201174|Actinobacteria	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0409	Acetate_kinase
k59_51074_2	1385518.N798_12530	1.51e-16	78.2	COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,2GJ5U@201174|Actinobacteria,4FFM6@85021|Intrasporangiaceae	201174|Actinobacteria	C	belongs to the CobB CobQ family	pta	-	2.3.1.8	ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,DRTGG,PTA_PTB
k59_283765_1	555779.Dthio_PD1536	5.71e-34	131.0	COG4974@1|root,COG4974@2|Bacteria,1NCBK@1224|Proteobacteria,42VT5@68525|delta/epsilon subdivisions,2WSFT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM integrase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1791586_2	593907.Celgi_0291	1.4e-41	144.0	COG1194@1|root,COG1194@2|Bacteria,2GJD9@201174|Actinobacteria,4F0K1@85016|Cellulomonadaceae	201174|Actinobacteria	L	FES	mutY	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_737716_1	1121948.AUAC01000002_gene1052	4.6e-49	176.0	COG2176@1|root,COG2176@2|Bacteria,1QUVW@1224|Proteobacteria,2TSZS@28211|Alphaproteobacteria,43ZJG@69657|Hyphomonadaceae	28211|Alphaproteobacteria	L	VRR_NUC	polC	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T,VRR_NUC
k59_679073_2	572477.Alvin_1048	2.22e-99	302.0	COG1449@1|root,COG1449@2|Bacteria,1R3Z3@1224|Proteobacteria,1RNRC@1236|Gammaproteobacteria,1WVY7@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_51079_1	1116472.MGMO_43c00040	8.8e-33	120.0	COG0637@1|root,COG0637@2|Bacteria,1QTT8@1224|Proteobacteria,1T1GC@1236|Gammaproteobacteria,1XE2I@135618|Methylococcales	135618|Methylococcales	S	PFAM Haloacid dehalogenase-like hydrolase	-	-	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_403684_1	1380354.JIAN01000007_gene358	1.98e-95	287.0	COG1277@1|root,COG1277@2|Bacteria,2GP6D@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter (Permease)	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
k59_1099566_1	367299.JOEE01000001_gene2132	2.14e-108	318.0	COG1028@1|root,COG1028@2|Bacteria,2GNUM@201174|Actinobacteria,4FF7H@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	HSD17B	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_403686_1	697282.Mettu_3886	4.7e-56	210.0	COG1749@1|root,COG2319@1|root,COG2372@1|root,COG1749@2|Bacteria,COG2319@2|Bacteria,COG2372@2|Bacteria,1MWJA@1224|Proteobacteria,1S1AJ@1236|Gammaproteobacteria,1XF66@135618|Methylococcales	135618|Methylococcales	N	WD40 repeat, subgroup	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082,WD40
k59_444416_1	1000565.METUNv1_03515	9.24e-87	264.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,2VH8U@28216|Betaproteobacteria,2KUZK@206389|Rhodocyclales	206389|Rhodocyclales	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
k59_110170_1	1085623.GNIT_2818	8.93e-18	81.3	COG0801@1|root,COG0801@2|Bacteria,1RHNN@1224|Proteobacteria,1S62M@1236|Gammaproteobacteria,46782@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase	folK2	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
k59_110170_2	713586.KB900536_gene2466	1.2e-96	290.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RMJU@1236|Gammaproteobacteria,1WXHM@135613|Chromatiales	135613|Chromatiales	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
k59_991295_1	94624.Bpet4350	3.14e-77	242.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VI9Q@28216|Betaproteobacteria,3T51C@506|Alcaligenaceae	28216|Betaproteobacteria	E	Serine-pyruvate aminotransferase archaeal aspartate aminotransferase	sgaA	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_403693_1	765912.Thimo_1361	5.91e-101	300.0	COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1RNDT@1236|Gammaproteobacteria,1WW02@135613|Chromatiales	135613|Chromatiales	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10,RmlD_sub_bind
k59_1383586_1	1454010.JEOE01000001_gene886	1.51e-44	158.0	2D1T0@1|root,32TBA@2|Bacteria,2I8E5@201174|Actinobacteria,4F1CG@85016|Cellulomonadaceae	201174|Actinobacteria	S	Copper transport outer membrane protein, MctB	mctB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0008150,GO:0009279,GO:0015267,GO:0015288,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0044425,GO:0044462,GO:0044464,GO:0046930,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098796	-	-	-	-	-	-	-	-	-	-	MctB
k59_1343549_1	870187.Thini_0666	9.01e-96	286.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,1RS0S@1236|Gammaproteobacteria,460HP@72273|Thiotrichales	72273|Thiotrichales	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine	-	-	2.4.2.44	ko:K19696	ko00270,ko01100,map00270,map01100	-	R09668	RC00063	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3,PNP_UDP_1
k59_151708_1	522306.CAP2UW1_3861	3.53e-70	237.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,2VJGQ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the UPF0753 family	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k59_1443446_1	379731.PST_0561	1.91e-142	442.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1Z0JD@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	E	COG0067 Glutamate synthase domain 1	gltB	GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iBWG_1329.BWG_2914,iECDH10B_1368.ECDH10B_3387,iECDH1ME8569_1439.EcDH1_0495,iEcDH1_1363.EcDH1_0495,iPC815.YPO3557	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1735736_1	306281.AJLK01000081_gene1682	4e-97	319.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria	1117|Cyanobacteria	Q	Amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
k59_1559400_1	670307.HYPDE_41543	2.6e-48	166.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TVFA@28211|Alphaproteobacteria,3N6UY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Transporter associated domain	tlyC	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
k59_620311_1	243231.GSU1615	5.18e-103	313.0	COG0526@1|root,COG0526@2|Bacteria,1MWDE@1224|Proteobacteria,42RCT@68525|delta/epsilon subdivisions,2WKJ9@28221|Deltaproteobacteria,43UJX@69541|Desulfuromonadales	28221|Deltaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
k59_679986_1	1034769.KB910518_gene3243	9.23e-56	191.0	COG1903@1|root,COG1903@2|Bacteria,1TQ3M@1239|Firmicutes,4HBDG@91061|Bacilli,26R5X@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A	cbiD	-	2.1.1.195	ko:K02188	ko00860,ko01100,map00860,map01100	-	R07773	RC00003,RC02051	ko00000,ko00001,ko01000	-	-	-	CbiD
k59_327396_1	1304865.JAGF01000001_gene1314	1.19e-45	155.0	COG5340@1|root,COG5340@2|Bacteria,2ICBY@201174|Actinobacteria	201174|Actinobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4,DUF559
k59_284759_1	671143.DAMO_1933	3.38e-83	275.0	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1871780_1	626887.J057_11556	2.11e-23	99.4	COG2928@1|root,COG2928@2|Bacteria,1NF4R@1224|Proteobacteria,1SFUD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Conserved Protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
k59_1508437_1	1396858.Q666_03210	1.37e-100	321.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RR1B@1236|Gammaproteobacteria,46421@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	ATP-dependent helicase HrpB	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_1026320_1	998674.ATTE01000001_gene158	2.29e-106	316.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,4600A@72273|Thiotrichales	72273|Thiotrichales	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_620323_1	1123400.KB904747_gene510	1.51e-16	79.3	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,45ZQK@72273|Thiotrichales	72273|Thiotrichales	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_620323_2	864073.HFRIS_001839	6.79e-64	200.0	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,2VR5W@28216|Betaproteobacteria,47446@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
k59_620323_3	713586.KB900536_gene2073	8.6e-90	272.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1T02D@1236|Gammaproteobacteria,1WW5T@135613|Chromatiales	135613|Chromatiales	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_1343597_1	519989.ECTPHS_05440	1.92e-87	269.0	COG2143@1|root,COG2143@2|Bacteria,1R72D@1224|Proteobacteria,1RSDK@1236|Gammaproteobacteria,1WVUU@135613|Chromatiales	135613|Chromatiales	O	Thioredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
k59_1343597_2	1205680.CAKO01000040_gene480	1e-34	129.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TQYV@28211|Alphaproteobacteria,2JPU4@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1617658_1	1168059.KB899087_gene2010	1.17e-39	139.0	COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2TRMG@28211|Alphaproteobacteria,3EYPB@335928|Xanthobacteraceae	28211|Alphaproteobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
k59_1099608_1	1713.JOFV01000009_gene339	1.46e-90	273.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4F0QS@85016|Cellulomonadaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	tcrX	GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0098771	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1099608_2	471853.Bcav_0020	4.17e-84	261.0	COG0705@1|root,COG0705@2|Bacteria,2GJYG@201174|Actinobacteria	201174|Actinobacteria	NU	Rhomboid family	gluP	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid,zf-B_box
k59_1026329_1	1121933.AUHH01000025_gene3088	1.23e-37	145.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4DNJG@85009|Propionibacteriales	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_327422_1	1347342.BN863_19530	3.14e-18	89.4	COG2885@1|root,COG2885@2|Bacteria,4NIY2@976|Bacteroidetes,1I02B@117743|Flavobacteriia	976|Bacteroidetes	M	flagellar motor protein MotB	-	-	-	-	-	-	-	-	-	-	-	-	DUF937,OmpA
k59_210161_1	903818.KI912268_gene1544	1.21e-07	54.7	COG1180@1|root,COG1180@2|Bacteria	2|Bacteria	C	glycyl-radical enzyme activating activity	nrdG	-	1.97.1.4,4.3.99.3	ko:K04069,ko:K10026	ko00790,ko01100,map00790,map01100	-	R04710,R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_12,Radical_SAM
k59_210161_2	1049564.TevJSym_be00050	1.35e-33	124.0	COG1242@1|root,COG1242@2|Bacteria,1MUYF@1224|Proteobacteria,1RP94@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	radical SAM protein	yhcC	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051539,GO:0051540	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
k59_1443496_1	1279017.AQYJ01000027_gene1618	3.37e-77	250.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,1RRN4@1236|Gammaproteobacteria,4674P@72275|Alteromonadaceae	1236|Gammaproteobacteria	EU	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
k59_1343622_1	933262.AXAM01000093_gene1586	1.08e-84	258.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,42N0M@68525|delta/epsilon subdivisions,2WJ7D@28221|Deltaproteobacteria,2MHZH@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM tyrosine recombinase XerD	xerD	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1386260_1	717785.HYPMC_4705	7.43e-51	164.0	COG0346@1|root,COG0346@2|Bacteria,1RIN8@1224|Proteobacteria,2U9WM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_1386260_2	582899.Hden_3390	3.3e-51	170.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,2TV4B@28211|Alphaproteobacteria,3N6S6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
k59_407788_1	768671.ThimaDRAFT_4609	3.57e-92	287.0	COG0674@1|root,COG0674@2|Bacteria,1QVAZ@1224|Proteobacteria,1S0VA@1236|Gammaproteobacteria,1WVZZ@135613|Chromatiales	135613|Chromatiales	C	pyruvate-flavodoxin oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_212925_1	648757.Rvan_1017	4.18e-11	70.9	COG1835@1|root,COG2755@1|root,COG1835@2|Bacteria,COG2755@2|Bacteria,1MV2W@1224|Proteobacteria,2TRT8@28211|Alphaproteobacteria,3N824@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	PFAM acyltransferase 3	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_1102666_1	545276.KB898725_gene723	1.45e-60	210.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_935866_1	1501230.ET33_33845	6.83e-07	49.7	COG1925@1|root,COG1925@2|Bacteria,1VN6R@1239|Firmicutes,4HS24@91061|Bacilli,26ZBT@186822|Paenibacillaceae	91061|Bacilli	G	PTS HPr component phosphorylation site	-	-	-	-	-	-	-	-	-	-	-	-	PTS-HPr
k59_935866_2	1249634.D781_3667	9.53e-154	440.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,400VR@613|Serratia	1236|Gammaproteobacteria	G	Catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate	fbaA	GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	iZ_1308.Z4263	F_bP_aldolase
k59_114273_1	765911.Thivi_3351	2.26e-87	287.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1WWGW@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM ATP-dependent helicase HrpA	-	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_407808_1	251229.Chro_3562	9.93e-109	332.0	COG0033@1|root,COG0033@2|Bacteria,1G0ZB@1117|Cyanobacteria,3VHQS@52604|Pleurocapsales	1117|Cyanobacteria	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_741462_2	32057.KB217478_gene967	2.56e-25	107.0	COG0463@1|root,COG0463@2|Bacteria,1GQ4G@1117|Cyanobacteria,1HN6Q@1161|Nostocales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_11
k59_55908_1	1454004.AW11_00918	9.72e-52	178.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria	28216|Betaproteobacteria	L	RNA-directed DNA polymerase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_1029787_1	439235.Dalk_3448	1.37e-87	271.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NMZ@68525|delta/epsilon subdivisions,2WIZ0@28221|Deltaproteobacteria,2MINS@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
k59_995127_1	1049564.TevJSym_an00350	7.66e-162	458.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1J4E7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2476,iB21_1397.B21_02330,iBWG_1329.BWG_2240,iE2348C_1286.E2348C_2713,iEC042_1314.EC042_2677,iEC55989_1330.EC55989_2759,iECABU_c1320.ECABU_c27880,iECBD_1354.ECBD_1213,iECB_1328.ECB_02368,iECDH10B_1368.ECDH10B_2642,iECDH1ME8569_1439.ECDH1ME8569_2402,iECDH1ME8569_1439.EcDH1_1193,iECD_1391.ECD_02368,iECED1_1282.ECED1_2911,iECH74115_1262.ECH74115_3698,iECIAI1_1343.ECIAI1_2527,iECNA114_1301.ECNA114_2561,iECO103_1326.ECO103_2988,iECO111_1330.ECO111_3199,iECO26_1355.ECO26_3522,iECOK1_1307.ECOK1_2784,iECP_1309.ECP_2490,iECS88_1305.ECS88_2658,iECSE_1348.ECSE_2760,iECSF_1327.ECSF_2329,iECSP_1301.ECSP_3415,iECUMN_1333.ECUMN_2789,iECW_1372.ECW_m2698,iECs_1301.ECs3338,iEKO11_1354.EKO11_1259,iETEC_1333.ETEC_2581,iEcDH1_1363.EcDH1_1193,iEcE24377_1341.EcE24377A_2757,iEcHS_1320.EcHS_A2607,iEcSMS35_1347.EcSMS35_2623,iEcolC_1368.EcolC_1200,iG2583_1286.G2583_2999,iJN746.PP_1240,iJO1366.b2476,iJR904.b2476,iLF82_1304.LF82_1775,iNRG857_1313.NRG857_12360,iSFV_1184.SFV_2521,iSF_1195.SF2519,iSFxv_1172.SFxv_2773,iS_1188.S2669,iSbBS512_1146.SbBS512_E2848,iUMNK88_1353.UMNK88_3071,iWFL_1372.ECW_m2698,iY75_1357.Y75_RS12925,iYL1228.KPN_02810,iZ_1308.Z3735	SAICAR_synt
k59_564500_1	158189.SpiBuddy_2443	7.7e-92	279.0	COG1172@1|root,COG1172@2|Bacteria,2J781@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_505950_1	221288.JH992901_gene2726	3.34e-35	133.0	COG1132@1|root,COG1132@2|Bacteria,1G0EY@1117|Cyanobacteria,1JI4S@1189|Stigonemataceae	1117|Cyanobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_505950_2	929562.Emtol_0733	1.04e-05	48.1	COG1858@1|root,COG1858@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	CCP_MauG,UnbV_ASPIC,VCBS
k59_288738_1	670307.HYPDE_35848	1.81e-78	239.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2TR06@28211|Alphaproteobacteria,3N6I5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_564507_1	1121440.AUMA01000011_gene2433	6.42e-79	248.0	COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,42NI3@68525|delta/epsilon subdivisions,2WJ6P@28221|Deltaproteobacteria,2M856@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_1562098_1	1163617.SCD_n02931	3.74e-110	329.0	COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,2VS6Y@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative metallopeptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2201,DUF2201_N
k59_55930_1	525373.HMPREF0766_12781	1.75e-81	258.0	COG0488@1|root,COG0488@2|Bacteria,4NES5@976|Bacteroidetes,1IQQ4@117747|Sphingobacteriia	976|Bacteroidetes	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
k59_937758_1	439235.Dalk_0676	6.59e-100	304.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria,2MIIZ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_1104023_1	471853.Bcav_3426	1.15e-61	201.0	COG0226@1|root,COG0226@2|Bacteria,2GJXD@201174|Actinobacteria	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_1104023_2	471853.Bcav_3425	1.13e-05	47.8	COG0573@1|root,COG0573@2|Bacteria,2GJDA@201174|Actinobacteria	201174|Actinobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_997022_1	1283300.ATXB01000001_gene2076	9.66e-43	151.0	COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,1XEX3@135618|Methylococcales	135618|Methylococcales	K	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,DUF3335
k59_997022_2	1120983.KB894570_gene1801	1.29e-16	79.7	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2TQSS@28211|Alphaproteobacteria,1JMZ9@119043|Rhodobiaceae	28211|Alphaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADH5_C,Proton_antipo_M,Proton_antipo_N
k59_290033_1	316274.Haur_4066	3.56e-16	77.8	COG0356@1|root,COG0356@2|Bacteria,2G6NF@200795|Chloroflexi,376W7@32061|Chloroflexia	32061|Chloroflexia	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_290033_2	1322246.BN4_12556	1.47e-08	53.9	COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,42VAI@68525|delta/epsilon subdivisions,2WRI4@28221|Deltaproteobacteria,2MCKI@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_1682183_1	391937.NA2_13657	4.35e-60	204.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2TSSI@28211|Alphaproteobacteria,43GSS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	AMP-binding enzyme	fadD3	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_331617_1	160492.XF_0190	4.71e-53	177.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,1X36H@135614|Xanthomonadales	135614|Xanthomonadales	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
k59_742753_1	335543.Sfum_1550	4.44e-103	330.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2MR5Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_448516_1	96561.Dole_0706	1.39e-92	281.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2MHTQ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_155839_3	1002339.HMPREF9373_2551	1.63e-21	95.1	COG0639@1|root,COG0639@2|Bacteria,1QE1Y@1224|Proteobacteria,1RRG9@1236|Gammaproteobacteria,3NKWT@468|Moraxellaceae	1236|Gammaproteobacteria	T	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33,Metallophos,PNKP-ligase_C,PNKP_ligase
k59_1349495_1	338963.Pcar_2280	2.26e-36	134.0	COG0589@1|root,COG0589@2|Bacteria,1RI4X@1224|Proteobacteria,42YHF@68525|delta/epsilon subdivisions,2WUMG@28221|Deltaproteobacteria,43UMK@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_624355_1	1537715.JQFJ01000002_gene1003	3.96e-13	68.2	COG1054@1|root,COG1054@2|Bacteria,1MUFV@1224|Proteobacteria,2TUB5@28211|Alphaproteobacteria,2K0HK@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the UPF0176 family	-	-	-	ko:K07146	-	-	-	-	ko00000	-	-	-	Rhodanese
k59_624355_2	1000565.METUNv1_00292	3.94e-31	116.0	COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,2WG5G@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the glutathione peroxidase family	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
k59_1148727_1	207559.Dde_2090	7.06e-58	201.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42MYN@68525|delta/epsilon subdivisions,2WIND@28221|Deltaproteobacteria,2M7TC@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_409678_1	1286093.C266_01979	6.2e-87	285.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,1JZZZ@119060|Burkholderiaceae	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_155843_1	935866.JAER01000038_gene4169	2.19e-111	351.0	COG5013@1|root,COG5013@2|Bacteria,2GKZU@201174|Actinobacteria,4DNS8@85009|Propionibacteriales	201174|Actinobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	narG	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding
k59_997045_1	1123073.KB899244_gene261	1.29e-136	427.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X5CT@135614|Xanthomonadales	135614|Xanthomonadales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_409681_2	305900.GV64_09110	3.29e-34	130.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria,1XK3U@135619|Oceanospirillales	135619|Oceanospirillales	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
k59_290075_1	1121403.AUCV01000026_gene2376	4.56e-70	227.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BWI@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
k59_1682204_1	745310.G432_00470	1.08e-100	305.0	COG2271@1|root,COG2271@2|Bacteria,1QVY6@1224|Proteobacteria,2TWTV@28211|Alphaproteobacteria,2KEFC@204457|Sphingomonadales	204457|Sphingomonadales	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_859180_1	1121405.dsmv_3317	4.66e-51	177.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2MI74@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	Sigma-54 interaction domain	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	HTH_8,PAS_4,PAS_9,Sigma54_activat
k59_290080_1	261292.Nit79A3_2953	2.53e-105	315.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,2VMP0@28216|Betaproteobacteria,373NG@32003|Nitrosomonadales	28216|Betaproteobacteria	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_214161_1	933262.AXAM01000036_gene2181	2.64e-122	382.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2WIVR@28221|Deltaproteobacteria,2MI3P@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1563262_2	1121396.KB892990_gene4486	3.39e-36	128.0	2E0F6@1|root,32W1G@2|Bacteria,1N6I3@1224|Proteobacteria,42V01@68525|delta/epsilon subdivisions,2WQWS@28221|Deltaproteobacteria,2MMAB@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_742788_1	765911.Thivi_3794	2.32e-102	314.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales	135613|Chromatiales	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_1739938_1	1123252.ATZF01000007_gene161	1.3e-10	59.3	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
k59_1031135_1	1229172.JQFA01000002_gene2087	3.97e-06	53.1	COG0616@1|root,COG0616@2|Bacteria,1G1AY@1117|Cyanobacteria,1H7U5@1150|Oscillatoriales	1117|Cyanobacteria	OU	signal peptide peptidase	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_1278556_1	631362.Thi970DRAFT_01755	7.53e-101	322.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWAU@135613|Chromatiales	135613|Chromatiales	U	Hydrophobe Amphiphile Efflux-1 (HAE1)	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_624395_1	1232410.KI421412_gene218	6.57e-60	207.0	COG0457@1|root,COG0457@2|Bacteria,1R1JQ@1224|Proteobacteria,4377S@68525|delta/epsilon subdivisions,2WTFW@28221|Deltaproteobacteria,43U9G@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
k59_1447210_1	1163617.SCD_n01412	1.14e-53	189.0	COG2199@1|root,COG2200@1|root,COG2203@1|root,COG3290@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG2203@2|Bacteria,COG3290@2|Bacteria,1RGKE@1224|Proteobacteria	1224|Proteobacteria	T	GAF domain	-	-	3.1.4.52	ko:K20962	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000	-	-	-	EAL,GAF,GAF_2,GGDEF,HWE_HK,PAS,PAS_3,PAS_4,PAS_8
k59_565794_1	713586.KB900536_gene2702	2.28e-96	308.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,1WWF7@135613|Chromatiales	135613|Chromatiales	H	TonB-dependent Receptor Plug	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
k59_742801_1	1306174.JODP01000006_gene3431	4.87e-14	72.0	COG0029@1|root,COG0029@2|Bacteria,2I2IJ@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16,2.4.2.19	ko:K00278,ko:K00767	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481,R03348	RC00006,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_742801_2	743718.Isova_2645	5.18e-41	145.0	COG0157@1|root,COG0157@2|Bacteria,2I2IP@201174|Actinobacteria,4F491@85017|Promicromonosporaceae	201174|Actinobacteria	H	Quinolinate phosphoribosyl transferase, C-terminal domain	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
k59_997122_2	519989.ECTPHS_01334	6e-28	110.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1WX4I@135613|Chromatiales	135613|Chromatiales	D	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1682254_1	520999.PROVALCAL_02876	3.05e-18	80.5	COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,1S3QM@1236|Gammaproteobacteria,3Z8PN@586|Providencia	1236|Gammaproteobacteria	S	Belongs to the UPF0178 family	yaiI	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
k59_1682254_2	1145276.T479_19620	1.78e-16	80.1	COG3573@1|root,COG3573@2|Bacteria,1UY39@1239|Firmicutes,4HBS3@91061|Bacilli,3IWM1@400634|Lysinibacillus	91061|Bacilli	S	Proposed role in polysaccahride synthesis	-	-	-	ko:K07077	-	-	-	-	ko00000	-	-	-	FAD_binding_2
k59_448573_1	1267005.KB911255_gene2763	2.05e-82	248.0	COG1376@1|root,COG1376@2|Bacteria,1NHM3@1224|Proteobacteria,2UHVV@28211|Alphaproteobacteria,3N8IS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_742817_1	335543.Sfum_1375	2.42e-84	261.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2WJT6@28221|Deltaproteobacteria,2MQ97@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_997126_1	762984.HMPREF9445_01760	9.95e-28	117.0	COG3250@1|root,COG3250@2|Bacteria,4NGZH@976|Bacteroidetes,2FNGV@200643|Bacteroidia,4AP9W@815|Bacteroidaceae	976|Bacteroidetes	G	Glycosyl hydrolase family 2, sugar binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106,Glyco_hydro_2_N
k59_937891_1	1163617.SCD_n02608	1.34e-134	394.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2VIZB@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	ko:K11102	-	-	-	-	ko00000,ko02000	2.A.23.1.1,2.A.23.1.2	-	-	SDF
k59_116223_1	105559.Nwat_0841	2.35e-63	207.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,1S22U@1236|Gammaproteobacteria,1X0RX@135613|Chromatiales	135613|Chromatiales	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_155914_1	589865.DaAHT2_0345	1.39e-12	73.9	COG1219@1|root,COG1219@2|Bacteria,1MWIZ@1224|Proteobacteria,42N1Z@68525|delta/epsilon subdivisions,2WJUS@28221|Deltaproteobacteria,2MHMD@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the ClpX chaperone family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
k59_1795989_1	748658.KB907313_gene2202	1.12e-54	184.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,1RM84@1236|Gammaproteobacteria,1WWYX@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM lysine 2,3-aminomutase YodO family protein	-	-	5.4.3.2	ko:K01843,ko:K19810	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000,ko03012	-	-	-	Fer4_12,Fer4_14,Radical_SAM
k59_116232_1	1452718.JBOY01000111_gene366	4.55e-56	189.0	COG3550@1|root,COG3550@2|Bacteria,1MVAB@1224|Proteobacteria,1RR5N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein related to capsule biosynthesis enzymes	-	-	2.7.11.1	ko:K07154	-	-	-	-	ko00000,ko01000,ko01001,ko02048	-	-	-	Couple_hipA,HipA_C
k59_290168_1	323097.Nham_0835	3.85e-47	157.0	COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2963 Transposase and inactivated derivatives	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_409800_2	580332.Slit_0816	7.31e-12	65.5	COG3090@1|root,COG3090@2|Bacteria,1PJMD@1224|Proteobacteria,2VYB1@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_1278614_2	1333998.M2A_0972	6.43e-57	187.0	COG0491@1|root,COG0491@2|Bacteria,1PKW8@1224|Proteobacteria,2TUW8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_742845_1	335543.Sfum_0458	2.59e-92	286.0	COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,42P03@68525|delta/epsilon subdivisions,2WIPY@28221|Deltaproteobacteria,2MR53@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	PFAM Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k59_1621522_1	1265505.ATUG01000001_gene3371	2.16e-09	62.4	COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,42U86@68525|delta/epsilon subdivisions,2WPKR@28221|Deltaproteobacteria,2MPQH@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Cytidylyltransferase family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
k59_57542_1	93220.LV28_00670	6.66e-28	108.0	COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,2VKF1@28216|Betaproteobacteria,1K3P4@119060|Burkholderiaceae	28216|Betaproteobacteria	P	phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_1515863_1	446470.Snas_2497	2.33e-07	51.2	COG0623@1|root,COG0623@2|Bacteria,2GJ65@201174|Actinobacteria,4EY3U@85014|Glycomycetales	201174|Actinobacteria	I	Enoyl-(Acyl carrier protein) reductase	inhA	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005504,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030312,GO:0030497,GO:0031406,GO:0032787,GO:0033293,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208,ko:K11611	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1515863_2	1240349.ANGC01000091_gene189	3.39e-48	162.0	COG1028@1|root,COG1028@2|Bacteria,2GK6C@201174|Actinobacteria,4FX54@85025|Nocardiaceae	201174|Actinobacteria	IQ	NAD dependent epimerase/dehydratase family	fabG1	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0018454,GO:0019752,GO:0030497,GO:0032787,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046459,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0070402,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059,ko:K11610	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_862143_1	1317118.ATO8_18175	1.27e-88	275.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1624095_1	981223.AIED01000009_gene3292	3.93e-08	55.8	COG0439@1|root,COG1984@1|root,COG2049@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,3NJ9U@468|Moraxellaceae	1236|Gammaproteobacteria	EI	Allophanate hydrolase subunit 2	uca	-	6.3.4.6	ko:K01941	ko00220,ko00791,ko01100,map00220,map00791,map01100	-	R00774	RC00378	ko00000,ko00001,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D
k59_1624095_2	740709.A10D4_06371	1.12e-08	58.9	COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,1RP3W@1236|Gammaproteobacteria,2QF4W@267893|Idiomarinaceae	1236|Gammaproteobacteria	C	decarboxylase	oadB	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
k59_334623_1	425104.Ssed_2865	1.38e-87	291.0	COG0642@1|root,COG0834@1|root,COG5002@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,2QACP@267890|Shewanellaceae	1236|Gammaproteobacteria	T	histidine kinase A domain protein	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	CHASE,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3,dCache_1
k59_1390125_1	1121440.AUMA01000010_gene317	1.99e-62	212.0	COG3850@1|root,COG4191@1|root,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WJKV@28221|Deltaproteobacteria,2M7VM@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K02482,ko:K10819	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9
k59_1107339_1	1035308.AQYY01000001_gene3134	7.4e-52	172.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,260YT@186807|Peptococcaceae	186801|Clostridia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_1282988_2	446468.Ndas_1545	2.72e-21	92.0	COG0748@1|root,COG0748@2|Bacteria,2IIRT@201174|Actinobacteria,4EQI1@85012|Streptosporangiales	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
k59_1282988_3	710686.Mycsm_02146	3.56e-07	50.4	COG1610@1|root,COG1610@2|Bacteria,2GQVP@201174|Actinobacteria,23B5A@1762|Mycobacteriaceae	201174|Actinobacteria	S	YqeY-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
k59_1451388_1	319224.Sputcn32_0673	4.16e-45	150.0	COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,1S2DE@1236|Gammaproteobacteria,2QB2K@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Uncharacterized protein family, UPF0114	yqhA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	UPF0114
k59_1035425_1	446471.Xcel_2006	4.65e-67	215.0	COG0547@1|root,COG0547@2|Bacteria,2GM4G@201174|Actinobacteria,4F3ZI@85017|Promicromonosporaceae	201174|Actinobacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
k59_159514_1	1095767.CAHD01000045_gene1386	1.59e-71	236.0	COG0247@1|root,COG0247@2|Bacteria,2GJ7M@201174|Actinobacteria	201174|Actinobacteria	C	Fe-S oxidoreductase	fadF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_746498_2	46429.BV95_00763	2.96e-05	51.2	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,2K06P@204457|Sphingomonadales	204457|Sphingomonadales	L	helicase	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
k59_797578_1	1232410.KI421425_gene1549	3.33e-83	273.0	COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,43CT2@68525|delta/epsilon subdivisions,2X80K@28221|Deltaproteobacteria,43TUA@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
k59_1799249_1	768671.ThimaDRAFT_1663	1.27e-28	110.0	COG5652@1|root,COG5652@2|Bacteria,1NGE7@1224|Proteobacteria,1SG7A@1236|Gammaproteobacteria,1WZI6@135613|Chromatiales	135613|Chromatiales	S	PFAM VanZ	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_797581_1	429009.Adeg_1572	1.73e-20	89.7	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,42EWY@68295|Thermoanaerobacterales	186801|Clostridia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_687776_2	313596.RB2501_10090	2.63e-88	276.0	COG2382@1|root,COG2382@2|Bacteria,4NGBK@976|Bacteroidetes,1I15X@117743|Flavobacteriia	976|Bacteroidetes	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_1391212_1	396588.Tgr7_1176	0.0	1190.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon
k59_1451418_1	1396141.BATP01000039_gene1381	8.06e-64	222.0	COG4630@1|root,COG4631@1|root,COG4630@2|Bacteria,COG4631@2|Bacteria,46Z71@74201|Verrucomicrobia,2IWQ8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	F	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_569688_1	1134474.O59_003420	2.78e-44	162.0	COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,1RNET@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Receptor	oprC	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1283026_2	743718.Isova_1821	4.05e-93	283.0	COG0547@1|root,COG0547@2|Bacteria,2GM4G@201174|Actinobacteria,4F3ZI@85017|Promicromonosporaceae	201174|Actinobacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
k59_569689_1	1121013.P873_12090	9.2e-80	254.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1X8AF@135614|Xanthomonadales	135614|Xanthomonadales	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1744191_2	159087.Daro_1764	1.93e-32	126.0	COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2VJ3Y@28216|Betaproteobacteria,2KV3H@206389|Rhodocyclales	206389|Rhodocyclales	C	Iron-sulfur cluster binding protein	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
k59_1391249_1	1227488.C477_05746	1.01e-36	143.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTXN@28890|Euryarchaeota,23SIS@183963|Halobacteria	183963|Halobacteria	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	lpdA1	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1283057_1	458817.Shal_3582	3.26e-70	219.0	COG1392@1|root,COG1392@2|Bacteria,1MXY9@1224|Proteobacteria,1RQHT@1236|Gammaproteobacteria,2QAEE@267890|Shewanellaceae	1236|Gammaproteobacteria	P	Protein of unknown function DUF47	VY92_08315	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_335845_1	1121875.KB907549_gene1885	2.03e-12	73.9	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes	976|Bacteroidetes	K	COGs COG5616 integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,Guanylate_cyc,HTH_18,TPR_8
k59_569713_1	768671.ThimaDRAFT_2883	4.88e-39	143.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,1WW19@135613|Chromatiales	135613|Chromatiales	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_569713_2	765913.ThidrDRAFT_0967	5.11e-41	143.0	COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,1S3T3@1236|Gammaproteobacteria,1WVZ9@135613|Chromatiales	135613|Chromatiales	S	subfamily IA, variant 1	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_1744196_1	1121468.AUBR01000051_gene2001	5.48e-14	76.6	COG1625@1|root,COG1625@2|Bacteria,1TSFU@1239|Firmicutes,247JK@186801|Clostridia,42EX0@68295|Thermoanaerobacterales	186801|Clostridia	C	Protein of unknown function (DUF512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF512,PDZ
k59_1744196_2	36874.HQ34_07345	6.51e-44	157.0	COG1160@1|root,COG1160@2|Bacteria,4NE2J@976|Bacteroidetes,2FN63@200643|Bacteroidia,22VY2@171551|Porphyromonadaceae	976|Bacteroidetes	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_863417_2	768671.ThimaDRAFT_2650	2.32e-46	161.0	COG4395@1|root,COG4395@2|Bacteria,1NSUG@1224|Proteobacteria,1S5PI@1236|Gammaproteobacteria,1WYB8@135613|Chromatiales	135613|Chromatiales	S	Tim44	-	-	-	-	-	-	-	-	-	-	-	-	Tim44
k59_1391259_1	469610.HMPREF0189_00019	1.4e-92	288.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2VHIA@28216|Betaproteobacteria,1KK1B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_1283073_1	1120950.KB892741_gene2626	3.06e-33	125.0	COG0413@1|root,COG0413@2|Bacteria,2GJP6@201174|Actinobacteria,4DNPX@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0034641,GO:0040007,GO:0042364,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_217811_1	1123236.KB899376_gene1249	4.11e-75	242.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,464A9@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	mltD	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_1216166_1	1000565.METUNv1_03021	1.26e-08	61.2	COG4591@1|root,COG4591@2|Bacteria,1Q2BY@1224|Proteobacteria,2VHS2@28216|Betaproteobacteria,2KVZT@206389|Rhodocyclales	206389|Rhodocyclales	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_746566_1	1047013.AQSP01000098_gene2559	3.15e-87	274.0	COG0481@1|root,COG0481@2|Bacteria,2NNXG@2323|unclassified Bacteria	2|Bacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_1391266_1	35841.BT1A1_2025	5.94e-22	99.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,4HA13@91061|Bacilli,1ZCMB@1386|Bacillus	91061|Bacilli	E	Aminotransferase	aspB	GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297	2.6.1.1,2.6.1.14	ko:K00812,ko:K22457	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R01346,R02433,R02619,R05052	RC00006,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_217821_1	270374.MELB17_11555	4.34e-85	271.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,463XQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_687843_1	926569.ANT_06670	2.82e-13	72.4	COG0747@1|root,COG0747@2|Bacteria,2G5NA@200795|Chloroflexi	200795|Chloroflexi	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1283097_1	880072.Desac_1918	5.17e-95	292.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2MRAR@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1283098_1	1049564.TevJSym_au00500	1.11e-59	191.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1J4QY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the KdsA family	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
k59_1283098_2	1444770.AF72_03900	1.59e-36	134.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1X2YM@135614|Xanthomonadales	135614|Xanthomonadales	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_452569_1	702113.PP1Y_AT25241	5.05e-20	92.8	COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,2U5RA@28211|Alphaproteobacteria,2JZWN@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
k59_1391288_1	880072.Desac_2372	3.31e-37	137.0	COG1463@1|root,COG1463@2|Bacteria,1Q6ZU@1224|Proteobacteria,42RZ3@68525|delta/epsilon subdivisions,2WNF0@28221|Deltaproteobacteria,2MRII@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	MlaD protein	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_1517335_1	367299.JOEE01000003_gene2877	9.25e-107	320.0	COG0179@1|root,COG0179@2|Bacteria,2GNGC@201174|Actinobacteria,4FF35@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Fumarylacetoacetase	fahA	-	3.7.1.2	ko:K01555	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FAA_hydrolase,FAA_hydrolase_N
k59_1517335_2	367299.JOEE01000003_gene2876	4.9e-05	44.7	COG0124@1|root,COG0124@2|Bacteria,2GJXW@201174|Actinobacteria,4FGGK@85021|Intrasporangiaceae	201174|Actinobacteria	J	histidyl-tRNA synthetase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1451502_2	643562.Daes_0067	1.35e-51	181.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,43AD6@68525|delta/epsilon subdivisions,2WJCC@28221|Deltaproteobacteria,2M8PA@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	transporter antisigma-factor antagonist STAS	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_746586_1	316067.Geob_1017	5.24e-170	487.0	COG4881@1|root,COG4881@2|Bacteria,1QXMX@1224|Proteobacteria,43C41@68525|delta/epsilon subdivisions,2WKYD@28221|Deltaproteobacteria,43TBN@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Polysulphide reductase, NrfD	cbcU	-	-	-	-	-	-	-	-	-	-	-	NrfD
k59_746586_2	443144.GM21_1067	6.17e-14	69.7	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42QZ2@68525|delta/epsilon subdivisions,2WMS4@28221|Deltaproteobacteria,43T2N@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	cbcT	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11,Fer4_2,Fer4_3,Fer4_7
k59_687862_1	1121405.dsmv_2868	2.38e-11	64.7	COG1028@1|root,COG1028@2|Bacteria,1QY8G@1224|Proteobacteria,42Z3G@68525|delta/epsilon subdivisions,2WUI5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1567075_1	1380354.JIAN01000006_gene441	2.35e-122	355.0	COG0214@1|root,COG0214@2|Bacteria,2GK1T@201174|Actinobacteria,4F0ND@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
k59_1686486_1	292415.Tbd_1534	1.51e-50	177.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria,1KRDI@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_1517347_1	553178.CAPGI0001_0670	9.91e-50	170.0	COG0148@1|root,COG0148@2|Bacteria,4NF5M@976|Bacteroidetes,1HWRR@117743|Flavobacteriia,1ER06@1016|Capnocytophaga	976|Bacteroidetes	H	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_452578_1	768671.ThimaDRAFT_0575	5.67e-311	857.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPN9@1236|Gammaproteobacteria,1WWMD@135613|Chromatiales	135613|Chromatiales	S	of ABC transporters with duplicated ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
k59_1686488_1	1996.JOFO01000015_gene983	4.25e-42	144.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4EGXW@85012|Streptosporangiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1686488_2	981369.JQMJ01000003_gene7909	1.64e-14	73.6	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria,2NHDN@228398|Streptacidiphilus	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_1152252_2	2340.JV46_27850	3.72e-57	182.0	COG0517@1|root,COG0517@2|Bacteria,1NJC6@1224|Proteobacteria,1SV2H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_1152252_3	96561.Dole_0965	3.54e-26	97.8	COG3360@1|root,COG3360@2|Bacteria,1Q2I5@1224|Proteobacteria,42VRR@68525|delta/epsilon subdivisions,2WRD2@28221|Deltaproteobacteria,2MM0N@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
k59_1035551_1	323261.Noc_1367	4.55e-95	299.0	COG1743@1|root,COG1743@2|Bacteria,1P7I6@1224|Proteobacteria,1RY2K@1236|Gammaproteobacteria,1WXME@135613|Chromatiales	135613|Chromatiales	L	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31,N6_N4_Mtase
k59_797654_1	1043205.AFYF01000045_gene2916	6.34e-80	261.0	COG1835@1|root,COG1835@2|Bacteria,2GKI5@201174|Actinobacteria,4FEY7@85021|Intrasporangiaceae	201174|Actinobacteria	I	Lipopolysaccharide modification acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_569772_1	713586.KB900536_gene143	4.64e-82	270.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales	135613|Chromatiales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2
k59_159637_1	1108045.GORHZ_126_00330	2.38e-68	224.0	COG1457@1|root,COG1457@2|Bacteria,2GKZN@201174|Actinobacteria,4GDQE@85026|Gordoniaceae	201174|Actinobacteria	U	Permease for cytosine/purines, uracil, thiamine, allantoin	-	-	-	-	-	-	-	-	-	-	-	-	Transp_cyt_pur
k59_1686504_1	387631.Asulf_01671	3.71e-19	91.7	arCOG02367@1|root,arCOG06940@1|root,arCOG02367@2157|Archaea,arCOG06940@2157|Archaea,2Y7WC@28890|Euryarchaeota	28890|Euryarchaeota	T	Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_1517370_1	504728.K649_03810	1.15e-51	177.0	COG0123@1|root,COG0123@2|Bacteria,1WIFA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	BQ	including yeast histone deacetylase and acetoin utilization protein	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
k59_511326_1	1121935.AQXX01000119_gene4763	6.17e-22	91.3	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,1RPJQ@1236|Gammaproteobacteria,1XIEI@135619|Oceanospirillales	135619|Oceanospirillales	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_511326_2	396588.Tgr7_0218	1.83e-50	162.0	COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,1S8R4@1236|Gammaproteobacteria,1WYHH@135613|Chromatiales	135613|Chromatiales	E	phosphoribosyl-ATP pyrophosphohydrolase	hisE	-	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
k59_1517372_1	864051.BurJ1DRAFT_0319	1.28e-101	306.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2VHDZ@28216|Betaproteobacteria,1KJX9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1744266_1	296591.Bpro_4334	4.34e-106	317.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria,4ABVU@80864|Comamonadaceae	28216|Betaproteobacteria	L	Integrase, catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_1451534_1	1054860.KB913030_gene3546	3.96e-32	120.0	COG0666@1|root,COG0666@2|Bacteria,2I9A2@201174|Actinobacteria	201174|Actinobacteria	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
k59_1686514_1	338966.Ppro_0784	1.13e-14	78.2	COG0475@1|root,COG0490@1|root,COG1226@1|root,COG0475@2|Bacteria,COG0490@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WK23@28221|Deltaproteobacteria,43T1F@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	ko:K03455,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
k59_217873_1	1957.JODX01000001_gene5194	0.000895	45.8	COG0406@1|root,COG0406@2|Bacteria,2GNRS@201174|Actinobacteria	201174|Actinobacteria	G	Phosphoglycerate mutase	-	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
k59_1152278_1	1193181.BN10_1130005	1.24e-65	216.0	COG0488@1|root,COG0488@2|Bacteria,2GK9S@201174|Actinobacteria,4FFDZ@85021|Intrasporangiaceae	201174|Actinobacteria	S	ABC transporter, ATP-binding protein	yjjK	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_1744277_1	292415.Tbd_1455	9.59e-57	184.0	COG3931@1|root,COG3931@2|Bacteria,1PWF0@1224|Proteobacteria,2VZYZ@28216|Betaproteobacteria,1KSK2@119069|Hydrogenophilales	119069|Hydrogenophilales	E	N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FGase
k59_1452802_1	1117647.M5M_04610	1.41e-94	285.0	COG0811@1|root,COG0811@2|Bacteria,1NXZ9@1224|Proteobacteria,1S154@1236|Gammaproteobacteria,1J4YC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	COG0811 Biopolymer transport proteins	-	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
k59_1285065_1	1382356.JQMP01000003_gene1985	1.89e-49	167.0	COG0363@1|root,COG0363@2|Bacteria,2G6S0@200795|Chloroflexi,27YBD@189775|Thermomicrobia	189775|Thermomicrobia	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	-	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
k59_864860_1	768671.ThimaDRAFT_3893	4.2e-76	251.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales	135613|Chromatiales	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_692151_1	880073.Calab_0711	7.16e-60	206.0	COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria	2|Bacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1395876_1	399742.Ent638_3887	7.52e-22	88.2	COG0236@1|root,COG0236@2|Bacteria,1N7Q1@1224|Proteobacteria,1SC83@1236|Gammaproteobacteria,3X41S@547|Enterobacter	1236|Gammaproteobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP2	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
k59_1395876_2	157783.LK03_07235	4.87e-21	90.1	COG0204@1|root,COG0204@2|Bacteria,1RDN7@1224|Proteobacteria,1S4Z5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
k59_573668_1	765912.Thimo_0893	2.89e-104	312.0	COG0526@1|root,COG0526@2|Bacteria,1MXG2@1224|Proteobacteria,1S08D@1236|Gammaproteobacteria,1WXCJ@135613|Chromatiales	135613|Chromatiales	CO	TraF-like protein	-	-	-	ko:K12057	-	-	-	-	ko00000,ko02044	3.A.7.11.1	-	-	TraF
k59_164319_2	187272.Mlg_0096	8.72e-45	162.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,1WW1M@135613|Chromatiales	135613|Chromatiales	S	ErfK YbiS YcfS YnhG family protein	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_1691163_1	1219065.VPR01S_05_00650	9.73e-55	186.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria,1XVID@135623|Vibrionales	135623|Vibrionales	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_1630203_1	471853.Bcav_3068	5.5e-159	452.0	COG0533@1|root,COG0533@2|Bacteria,2GJ98@201174|Actinobacteria	201174|Actinobacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
k59_751306_1	1123354.AUDR01000015_gene398	4.13e-25	107.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEV@28216|Betaproteobacteria,1KRD9@119069|Hydrogenophilales	28216|Betaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_164323_1	1121403.AUCV01000007_gene1220	5.51e-56	188.0	COG0515@1|root,COG0515@2|Bacteria,1MVPF@1224|Proteobacteria,42PCV@68525|delta/epsilon subdivisions,2WJHA@28221|Deltaproteobacteria,2MJB1@213118|Desulfobacterales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_456385_1	1121948.AUAC01000005_gene2012	9.19e-11	68.6	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,2TWZ1@28211|Alphaproteobacteria,44159@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Trans_reg_C
k59_164329_1	675813.VIB_002911	5.78e-43	154.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,1RSAV@1236|Gammaproteobacteria,1XZ6X@135623|Vibrionales	135623|Vibrionales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_692174_1	2340.JV46_14330	1.39e-45	166.0	COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_573690_1	1244869.H261_10079	9.98e-24	105.0	COG2114@1|root,COG3087@1|root,COG2114@2|Bacteria,COG3087@2|Bacteria,1R86S@1224|Proteobacteria,2U57P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4071,Guanylate_cyc
k59_514982_1	1121403.AUCV01000017_gene4453	2.45e-98	302.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2WJT7@28221|Deltaproteobacteria,2MI5B@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_632786_1	1521187.JPIM01000072_gene2385	2.34e-07	52.4	COG0119@1|root,COG0119@2|Bacteria,2G5V9@200795|Chloroflexi,374VT@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_632786_2	267608.RSc0948	1.64e-32	126.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VJ15@28216|Betaproteobacteria,1K4KC@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_868582_1	762376.AXYL_05548	3.07e-110	325.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2VI5Z@28216|Betaproteobacteria,3T1ZZ@506|Alcaligenaceae	28216|Betaproteobacteria	Q	2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-17-dioic acid hydratase (catechol pathway)	-	-	-	ko:K18336	ko00051,ko01120,map00051,map01120	-	R10691	RC00326,RC03236	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
k59_692183_2	1238190.AMQY01000014_gene789	4.89e-13	68.9	COG1120@1|root,COG1120@2|Bacteria,1MWPV@1224|Proteobacteria,1T1UT@1236|Gammaproteobacteria,1XINE@135619|Oceanospirillales	135619|Oceanospirillales	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_1456260_1	1304865.JAGF01000001_gene3183	7.87e-236	680.0	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,4F0NB@85016|Cellulomonadaceae	201174|Actinobacteria	EF	Carbamoyl-phosphate synthetase large chain domain protein	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_1572073_1	367299.JOEE01000001_gene1695	7.82e-94	296.0	COG0619@1|root,COG1122@1|root,COG0619@2|Bacteria,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,4FESH@85021|Intrasporangiaceae	201174|Actinobacteria	P	ABC transporter, ATP-binding protein	ykoD	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,CbiQ
k59_1289213_1	1149133.ppKF707_1010	1.52e-64	214.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,1RMGS@1236|Gammaproteobacteria,1YF9E@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	IQ	AMP-binding enzyme	-	-	6.2.1.44	ko:K20034	ko00920,map00920	-	R10820	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_692192_1	1121035.AUCH01000014_gene2374	2.48e-99	302.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2VI55@28216|Betaproteobacteria,2KV17@206389|Rhodocyclales	206389|Rhodocyclales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_573705_1	493475.GARC_4066	3.81e-119	360.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,465EX@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_800877_2	1454010.JEOE01000014_gene1391	2.76e-49	160.0	COG3255@1|root,COG3255@2|Bacteria,2IQBF@201174|Actinobacteria,4F1B2@85016|Cellulomonadaceae	201174|Actinobacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
k59_222531_1	2340.JV46_13060	1.66e-79	248.0	COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,1RQ0T@1236|Gammaproteobacteria,1J5E5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	ldh	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_222534_1	1157637.KB892112_gene5187	1.46e-43	145.0	COG0239@1|root,COG0239@2|Bacteria,2IKWG@201174|Actinobacteria	201174|Actinobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB1	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
k59_222534_2	994479.GL877880_gene3821	6.97e-22	87.8	COG1993@1|root,COG1993@2|Bacteria,2IM7J@201174|Actinobacteria,4E77D@85010|Pseudonocardiales	201174|Actinobacteria	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
k59_164373_1	93220.LV28_15080	1.02e-43	157.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2VI4V@28216|Betaproteobacteria,1K1JQ@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
k59_1114485_1	1384056.N787_09605	3.6e-58	202.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1RQK9@1236|Gammaproteobacteria,1X4NF@135614|Xanthomonadales	135614|Xanthomonadales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.6	ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1289248_1	382464.ABSI01000016_gene642	2.96e-86	256.0	COG0377@1|root,COG0377@2|Bacteria,46SMM@74201|Verrucomicrobia,2ITJ6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_692212_1	1249627.D779_4189	1.22e-138	433.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1141@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1141@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1WX9H@135613|Chromatiales	135613|Chromatiales	C	pyruvate flavodoxin ferredoxin oxidoreductase	-	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1040944_1	1198232.CYCME_0381	4.62e-09	57.0	COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,1RS0K@1236|Gammaproteobacteria,461AS@72273|Thiotrichales	72273|Thiotrichales	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
k59_1803170_1	765911.Thivi_3362	1.09e-109	324.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,1WX6S@135613|Chromatiales	135613|Chromatiales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
k59_1572117_1	387092.NIS_0653	1.88e-75	244.0	COG0074@1|root,COG0372@1|root,COG0074@2|Bacteria,COG0372@2|Bacteria,1MUGA@1224|Proteobacteria,42NI0@68525|delta/epsilon subdivisions,2YNKI@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	ATP citrate synthase	-	-	2.3.3.8	ko:K15230	ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200	M00173	R00352	RC00004,RC00067	ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt,Ligase_CoA
k59_456448_1	314278.NB231_08132	3.81e-87	286.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1289302_1	903818.KI912269_gene112	3.3e-50	182.0	COG0366@1|root,COG3408@1|root,COG0366@2|Bacteria,COG3408@2|Bacteria,3Y2ZW@57723|Acidobacteria	57723|Acidobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_340472_1	1297742.A176_00719	3.41e-61	205.0	COG1914@1|root,COG1914@2|Bacteria	2|Bacteria	P	metal ion transmembrane transporter activity	mntH	-	-	-	-	-	-	-	-	-	-	-	Nramp
k59_868662_1	1484479.DI14_14795	1.66e-34	133.0	COG3711@1|root,COG3711@2|Bacteria,1TQJJ@1239|Firmicutes,4HBB3@91061|Bacilli,3WFD8@539002|Bacillales incertae sedis	91061|Bacilli	K	CAT RNA binding domain	glcT	-	-	ko:K03480,ko:K03488	-	-	-	-	ko00000,ko03000	-	-	-	CAT_RBD,PRD
k59_1803196_2	740709.A10D4_00815	9.5e-40	137.0	COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,1S6AJ@1236|Gammaproteobacteria,2QFZJ@267893|Idiomarinaceae	1236|Gammaproteobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
k59_1803196_3	395493.BegalDRAFT_1166	7.57e-73	222.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,1S3WD@1236|Gammaproteobacteria,460J0@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
k59_1803196_4	396588.Tgr7_1561	2.28e-16	77.8	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1WW6K@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_800928_1	666685.R2APBS1_1303	9.31e-15	73.6	COG0500@1|root,COG2226@2|Bacteria,1QYDD@1224|Proteobacteria,1T4PJ@1236|Gammaproteobacteria,1XA92@135614|Xanthomonadales	135614|Xanthomonadales	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1220998_1	428125.CLOLEP_01526	2.75e-85	270.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,3WH0N@541000|Ruminococcaceae	186801|Clostridia	P	Belongs to the P(II) protein family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,P-II
k59_868701_1	352165.HMPREF7215_2335	4.89e-14	71.2	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3
k59_1041048_1	998088.B565_0325	3.59e-78	239.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria,1Y5GR@135624|Aeromonadales	135624|Aeromonadales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
k59_222643_2	1157632.AQWQ01000015_gene3396	3.58e-06	50.4	COG0366@1|root,COG0366@2|Bacteria,2GIV1@201174|Actinobacteria	201174|Actinobacteria	G	trehalose synthase	malL	-	2.4.1.4,3.2.1.1,3.2.1.20,5.4.99.16	ko:K01187,ko:K05341,ko:K05343	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R01557,R01823,R02108,R02112,R06087,R06088,R11262	RC00028,RC00049,RC00077,RC01816	ko00000,ko00001,ko01000	-	GH13,GH31	-	Alpha-amylase,DUF3459
k59_164478_1	1223543.GP2_036_00050	3.61e-45	159.0	COG2304@1|root,COG2304@2|Bacteria,2GKDC@201174|Actinobacteria,4GBPP@85026|Gordoniaceae	201174|Actinobacteria	S	von Willebrand factor type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	ADP_ribosyl_GH,VWA
k59_164478_2	1238182.C882_4167	6.44e-05	45.4	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,HTH_31
k59_164479_1	526222.Desal_2896	1.81e-112	332.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,42PCA@68525|delta/epsilon subdivisions,2WM39@28221|Deltaproteobacteria,2MGBC@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_800949_1	765912.Thimo_3043	8.78e-94	289.0	COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,1RPDV@1236|Gammaproteobacteria,1WXSP@135613|Chromatiales	135613|Chromatiales	G	alpha beta alpha domain I	-	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_751476_1	1454004.AW11_00850	3.23e-24	107.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg
k59_515074_1	553385.JEMF01000016_gene462	5.76e-20	85.5	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,1XJPI@135619|Oceanospirillales	135619|Oceanospirillales	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
k59_515074_2	1121940.AUDZ01000007_gene2313	1.49e-26	108.0	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,1XJFS@135619|Oceanospirillales	135619|Oceanospirillales	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
k59_1748568_1	1454010.JEOE01000003_gene341	1.22e-21	98.2	COG2141@1|root,COG2141@2|Bacteria,2GJN5@201174|Actinobacteria	201174|Actinobacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_751487_1	1121028.ARQE01000006_gene4427	2.28e-37	136.0	COG0436@1|root,COG0436@2|Bacteria,1MX6F@1224|Proteobacteria,2TTAA@28211|Alphaproteobacteria,2PJCG@255475|Aurantimonadaceae	28211|Alphaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	aspB1	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_1157515_2	1123322.KB904678_gene3183	8.06e-21	87.8	2AAWD@1|root,3109H@2|Bacteria,2IG0D@201174|Actinobacteria	201174|Actinobacteria	S	Alkylmercury lyase	-	-	-	-	-	-	-	-	-	-	-	-	MerB
k59_870350_1	1123368.AUIS01000020_gene1085	6.64e-10	62.0	COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,1S416@1236|Gammaproteobacteria,2NBVF@225057|Acidithiobacillales	225057|Acidithiobacillales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1749798_1	367299.JOEE01000005_gene3441	9.7e-84	254.0	COG0494@1|root,COG0494@2|Bacteria,2GNW6@201174|Actinobacteria,4FH1U@85021|Intrasporangiaceae	201174|Actinobacteria	L	ADP-ribose pyrophosphatase	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_224154_1	1304865.JAGF01000001_gene3857	4.75e-160	478.0	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4F11C@85016|Cellulomonadaceae	201174|Actinobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_516026_1	452637.Oter_3164	3.85e-41	153.0	COG1033@1|root,COG1033@2|Bacteria	2|Bacteria	S	growth of symbiont in host cell	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_516026_2	1278309.KB907099_gene2563	1.82e-10	68.2	COG4447@1|root,COG4447@2|Bacteria,1R84R@1224|Proteobacteria,1SZVU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
k59_1573868_1	351016.RAZWK3B_19196	1.33e-79	248.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TTAW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_870360_1	1232410.KI421421_gene3608	7e-80	251.0	COG0526@1|root,COG0526@2|Bacteria,1MWDE@1224|Proteobacteria,42RCT@68525|delta/epsilon subdivisions,2WKJ9@28221|Deltaproteobacteria,43UJX@69541|Desulfuromonadales	28221|Deltaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
k59_224174_1	1042375.AFPL01000032_gene1025	3.2e-20	95.1	COG1474@1|root,COG1474@2|Bacteria	2|Bacteria	LO	Belongs to the peptidase S16 family	-	-	3.6.1.3	ko:K07132	-	-	-	-	ko00000,ko01000	-	-	-	AAA_16,AAA_22,GerE,TniB,Trypsin_2,WD40
k59_1692853_1	313628.LNTAR_18248	1.96e-32	130.0	COG0569@1|root,COG0569@2|Bacteria	2|Bacteria	P	domain protein	trkA	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0015075,GO:0015672,GO:0016020,GO:0022857,GO:0030001,GO:0034220,GO:0051179,GO:0051234,GO:0055085,GO:0098655	-	ko:K03499,ko:K05571	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4,2.A.63.1,2.A.63.2	-	iE2348C_1286.E2348C_3552	TrkA_C,TrkA_N
k59_634129_1	519989.ECTPHS_10531	6.5e-119	354.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1WVZB@135613|Chromatiales	135613|Chromatiales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_1692856_1	711393.AYRX01000077_gene574	1.87e-23	100.0	COG1156@1|root,COG1156@2|Bacteria,2GKPJ@201174|Actinobacteria	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1692856_2	1304865.JAGF01000001_gene100	5.55e-35	130.0	COG1394@1|root,COG1394@2|Bacteria	2|Bacteria	C	ATPase activity, coupled to transmembrane movement of substances	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
k59_753063_1	1235457.C404_22415	2.09e-85	266.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2VJ29@28216|Betaproteobacteria,1K10P@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	algC	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_802133_1	1122962.AULH01000004_gene2340	0.000226	42.4	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria,36XAE@31993|Methylocystaceae	28211|Alphaproteobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_802133_2	935840.JAEQ01000005_gene1290	5.4e-60	206.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,43H9E@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1573901_1	1121957.ATVL01000014_gene1521	4.2e-62	218.0	COG0784@1|root,COG3604@1|root,COG0784@2|Bacteria,COG3604@2|Bacteria,4PMAT@976|Bacteroidetes,47Y62@768503|Cytophagia	976|Bacteroidetes	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,GAF_3,HTH_8,PAS_9,Response_reg,Sigma54_activat
k59_634136_1	304371.MCP_0978	3.16e-29	109.0	COG2146@1|root,arCOG02852@2157|Archaea,2Y74T@28890|Euryarchaeota,2NBB7@224756|Methanomicrobia	224756|Methanomicrobia	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_634136_2	1282360.ABAC460_12155	3.7e-15	72.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,2TU3T@28211|Alphaproteobacteria,2KGDY@204458|Caulobacterales	204458|Caulobacterales	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
k59_753070_2	180281.CPCC7001_1845	8.04e-46	154.0	COG0426@1|root,COG0426@2|Bacteria,1GPET@1117|Cyanobacteria,22SW2@167375|Cyanobium	1117|Cyanobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1160992_1	1307761.L21SP2_2409	2.05e-31	119.0	2EDDS@1|root,32W4M@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_345521_1	1049564.TevJSym_bd00010	1.47e-16	75.1	COG3439@1|root,COG3439@2|Bacteria,1RA8I@1224|Proteobacteria,1S34D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_345521_2	765912.Thimo_3369	1.21e-25	102.0	COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,1S6X3@1236|Gammaproteobacteria,1WWFD@135613|Chromatiales	135613|Chromatiales	K	PFAM Cyclic nucleotide-binding	-	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_228091_1	96561.Dole_1575	4.93e-49	176.0	COG0699@1|root,COG4649@1|root,COG0699@2|Bacteria,COG4649@2|Bacteria,1R3WJ@1224|Proteobacteria,42N0G@68525|delta/epsilon subdivisions,2WKFJ@28221|Deltaproteobacteria,2MJ5I@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_1753163_1	395494.Galf_1381	7.73e-73	242.0	COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,44WDS@713636|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM CoA-binding domain protein	yfiQ	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1697178_1	643648.Slip_2216	2.98e-23	94.7	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,42JTV@68298|Syntrophomonadaceae	186801|Clostridia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS20110	ADK,ADK_lid
k59_1697178_2	1380390.JIAT01000011_gene2608	2.22e-68	220.0	COG0201@1|root,COG0201@2|Bacteria,2GJ26@201174|Actinobacteria,4CPTT@84995|Rubrobacteria	84995|Rubrobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_1047860_1	1288826.MSNKSG1_01613	6.76e-26	101.0	COG0702@1|root,COG0702@2|Bacteria,1R8B9@1224|Proteobacteria,1S2S7@1236|Gammaproteobacteria,46A87@72275|Alteromonadaceae	1236|Gammaproteobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
k59_1753167_1	1049564.TevJSym_bd00330	3.08e-23	99.4	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,1T20U@1236|Gammaproteobacteria,1JAKX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Nickel-dependent hydrogenase	hoxH	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
k59_1753167_2	207954.MED92_07386	2.16e-33	125.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,1RW0G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Coenzyme F420-reducing hydrogenase, gamma subunit	hoxY	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
k59_1697185_2	743718.Isova_2350	8.64e-17	83.2	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4F3T1@85017|Promicromonosporaceae	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_518729_1	1408439.JHXW01000005_gene1098	1.95e-79	244.0	COG1209@1|root,COG1209@2|Bacteria,3790C@32066|Fusobacteria	32066|Fusobacteria	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_805499_1	640512.BC1003_0532	1.43e-34	121.0	COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,2VTXZ@28216|Betaproteobacteria,1K8PZ@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Regulatory protein ArsR	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20
k59_805499_2	317655.Sala_2338	5.66e-47	156.0	COG0346@1|root,COG0346@2|Bacteria,1RHIV@1224|Proteobacteria,2TR4K@28211|Alphaproteobacteria,2K47U@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_757156_1	1298880.AUEV01000018_gene328	5.19e-63	211.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0008150,GO:0040007	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
k59_1161020_1	2340.JV46_13050	8.06e-65	207.0	COG1014@1|root,COG1144@1|root,COG1014@2|Bacteria,COG1144@2|Bacteria,1N12F@1224|Proteobacteria,1S7UK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
k59_1047890_1	1121440.AUMA01000009_gene684	3.16e-12	65.5	COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,42PN7@68525|delta/epsilon subdivisions,2WIRP@28221|Deltaproteobacteria,2M8YK@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1047890_2	335543.Sfum_0314	7.21e-44	153.0	COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,42PN2@68525|delta/epsilon subdivisions,2WM53@28221|Deltaproteobacteria,2MRX0@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_1461664_1	1236959.BAMT01000001_gene1598	3.39e-08	62.0	COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2VPMU@28216|Betaproteobacteria,2KKDY@206350|Nitrosomonadales	1224|Proteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_637430_1	1219065.VPR01S_02_00420	5.53e-50	161.0	COG0347@1|root,COG0347@2|Bacteria,1RI28@1224|Proteobacteria,1S62Z@1236|Gammaproteobacteria,1XXA8@135623|Vibrionales	135623|Vibrionales	K	Belongs to the P(II) protein family	VV0993	-	-	-	-	-	-	-	-	-	-	-	-
k59_345555_1	1026882.MAMP_02902	3.43e-17	80.9	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,45ZZU@72273|Thiotrichales	72273|Thiotrichales	S	Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_170158_1	269796.Rru_A0943	1.4e-45	162.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2TUHH@28211|Alphaproteobacteria,2JPDC@204441|Rhodospirillales	204441|Rhodospirillales	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
k59_875144_2	316275.VSAL_I0750	1.27e-31	124.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1XTXA@135623|Vibrionales	135623|Vibrionales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_1697226_1	443152.MDG893_20124	4.4e-22	92.4	COG1187@1|root,COG1187@2|Bacteria,1MU6M@1224|Proteobacteria,1RQA9@1236|Gammaproteobacteria,46734@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rsuA	-	5.4.99.19	ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_1697226_2	519989.ECTPHS_06712	2.12e-13	69.7	COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria,1WXST@135613|Chromatiales	135613|Chromatiales	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	cpdA	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos
k59_805527_1	1122929.KB908217_gene197	1.26e-11	70.9	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2TRU2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
k59_697437_1	2340.JV46_20400	2.99e-39	144.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1J5MF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NADH ubiquinone oxidoreductase subunit	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_697437_2	1469245.JFBG01000086_gene1617	2.54e-79	257.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1WWQ6@135613|Chromatiales	135613|Chromatiales	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_1807800_1	1219045.BV98_000175	0.00012	50.1	COG4888@1|root,COG4888@2|Bacteria	2|Bacteria	G	ASPIC UnbV domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,UnbV_ASPIC,VCBS
k59_1753214_1	185453.XP_006831788.1	4.9e-09	63.5	28KV9@1|root,2QTBN@2759|Eukaryota,38DU3@33154|Opisthokonta,3BBCZ@33208|Metazoa,3CTUR@33213|Bilateria,485U4@7711|Chordata,49320@7742|Vertebrata,3J4VU@40674|Mammalia,354Y0@311790|Afrotheria	33208|Metazoa	S	Transmembrane protein 62	TMEM62	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_461250_1	999541.bgla_1g29240	2.76e-36	134.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VJJ1@28216|Betaproteobacteria,1K079@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_461250_2	1469245.JFBG01000086_gene1622	1.5e-51	181.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM NADH-quinone oxidoreductase, chain G	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1401810_1	367299.JOEE01000002_gene2391	1.56e-85	263.0	COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,4FF0X@85021|Intrasporangiaceae	201174|Actinobacteria	C	Pyruvate dehydrogenase E1	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_1401810_2	367299.JOEE01000002_gene2390	2.95e-86	261.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4FF51@85021|Intrasporangiaceae	201174|Actinobacteria	C	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_637464_1	515635.Dtur_0673	1.07e-47	171.0	COG1132@1|root,COG1132@2|Bacteria	2|Bacteria	V	(ABC) transporter	MdlB	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1226977_1	1173027.Mic7113_2390	1.03e-74	244.0	COG1505@1|root,COG1505@2|Bacteria,1G1B7@1117|Cyanobacteria,1H87F@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_578498_1	561231.Pecwa_4007	1.12e-89	283.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1MPVX@122277|Pectobacterium	1236|Gammaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1578469_2	981369.JQMJ01000004_gene3096	1.61e-68	232.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,2NH1Z@228398|Streptacidiphilus	201174|Actinobacteria	L	UvrD-like helicase C-terminal domain	pcrA	GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1807845_1	264732.Moth_1909	1.26e-64	223.0	COG3383@1|root,COG3383@2|Bacteria,1TT6D@1239|Firmicutes,24YN9@186801|Clostridia,42FDP@68295|Thermoanaerobacterales	186801|Clostridia	C	Formate dehydrogenase alpha subunit	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_875218_1	1209989.TepiRe1_1288	7.32e-29	114.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,247NJ@186801|Clostridia,42EMN@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k59_875218_2	416591.Tlet_0307	5.76e-18	79.7	COG1862@1|root,COG1862@2|Bacteria,2GDAR@200918|Thermotogae	200918|Thermotogae	U	TIGRFAM preprotein translocase, YajC subunit	-	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
k59_805581_1	367299.JOEE01000005_gene3481	1.41e-114	339.0	COG0192@1|root,COG0192@2|Bacteria,2GJ4U@201174|Actinobacteria,4FF9B@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_518801_1	1122599.AUGR01000019_gene3062	5.78e-68	228.0	COG3292@1|root,COG3292@2|Bacteria,1QMJ4@1224|Proteobacteria,1S1W2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
k59_1161102_1	1223544.GSI01S_15_00720	1.94e-86	262.0	COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria,4GCW2@85026|Gordoniaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_757238_1	716928.AJQT01000047_gene2151	1.23e-65	210.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TUAN@28211|Alphaproteobacteria,4B76N@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ABC transporter permease	MA20_03545	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_637490_1	493475.GARC_2937	1.75e-96	292.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,4647T@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	GO:0001522,GO:0003674,GO:0003824,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016769,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	iPC815.YPO2896,iYL1228.KPN_02862	Aminotran_5
k59_1047992_1	266779.Meso_1761	3.96e-74	234.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2TSKF@28211|Alphaproteobacteria,43HEP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
k59_461293_1	641491.DND132_0753	3.07e-41	153.0	COG0531@1|root,COG0531@2|Bacteria,1QXK2@1224|Proteobacteria,42MZD@68525|delta/epsilon subdivisions,2WRDK@28221|Deltaproteobacteria,2M9EC@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_1401867_1	765912.Thimo_2212	8.43e-142	418.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1WXXQ@135613|Chromatiales	135613|Chromatiales	G	Alpha amylase catalytic	-	-	2.4.1.7	ko:K00690	ko00500,map00500	-	R00803	RC00028	ko00000,ko00001,ko01000	-	GH13	-	-
k59_1048002_1	1255043.TVNIR_1207	2.42e-80	240.0	COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,1RN4S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	alkyl hydroperoxide reductase	ahpC	GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009321,GO:0009605,GO:0009636,GO:0009970,GO:0009987,GO:0009991,GO:0010033,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0032843,GO:0032991,GO:0033194,GO:0033195,GO:0033212,GO:0033214,GO:0033554,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071496,GO:0097237,GO:0098754,GO:0098771,GO:0098869,GO:1901700,GO:1902494,GO:1990204,GO:1990748	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
k59_875245_1	670307.HYPDE_29413	2.93e-90	269.0	2CDCV@1|root,308Y1@2|Bacteria,1N74F@1224|Proteobacteria,2TUJ4@28211|Alphaproteobacteria,3N7QI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1636528_1	652103.Rpdx1_1257	2.72e-43	152.0	COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,2TU8X@28211|Alphaproteobacteria,3JXBR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator, Crp Fnr family	-	-	-	ko:K01420,ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_1636528_2	1000565.METUNv1_03872	5.93e-20	81.6	2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,2VVS2@28216|Betaproteobacteria,2KX8R@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
k59_228228_1	631362.Thi970DRAFT_03101	1.97e-76	238.0	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,1RQ3P@1236|Gammaproteobacteria,1WWD7@135613|Chromatiales	135613|Chromatiales	GK	pfam rok	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	ROK
k59_805605_1	667632.KB890179_gene121	4.9e-59	192.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,2VMRG@28216|Betaproteobacteria,1K27N@119060|Burkholderiaceae	28216|Betaproteobacteria	G	fructose-bisphosphate aldolase	fbaB	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
k59_805605_2	1336235.JAEG01000004_gene3752	2.15e-59	192.0	296ZZ@1|root,2ZU8H@2|Bacteria,1RED2@1224|Proteobacteria,2U6CK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_805605_3	749222.Nitsa_0963	1.78e-37	138.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,42P56@68525|delta/epsilon subdivisions,2YNV5@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_1807885_1	67257.JODR01000010_gene3275	7.71e-151	458.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,2GJ11@201174|Actinobacteria	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
k59_1162750_2	1304275.C41B8_10328	6.01e-40	141.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RM9H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG0767 ABC-type transport system involved in resistance to organic solvents, permease component	mlaE	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_1050444_1	519989.ECTPHS_08563	3.41e-73	228.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,1WX6T@135613|Chromatiales	135613|Chromatiales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
k59_1050444_2	314278.NB231_01359	9.2e-113	362.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon
k59_639009_1	246194.CHY_2340	8.17e-17	85.9	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,42ETH@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_1699173_1	1033802.SSPSH_003276	5e-20	96.7	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Type II secretory pathway component ExeA	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
k59_1404057_1	2340.JV46_11800	2.17e-49	164.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,1RMHS@1236|Gammaproteobacteria,1J5PA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2500,iBWG_1329.BWG_2264,iECDH10B_1368.ECDH10B_2666,iECDH1ME8569_1439.ECDH1ME8569_2426,iEcDH1_1363.EcDH1_1169,iJO1366.b2500,iJR904.b2500,iY75_1357.Y75_RS13050	Formyl_trans_N
k59_1754796_1	1343740.M271_33065	6e-67	218.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria	201174|Actinobacteria	Q	pyridine nucleotide-disulphide oxidoreductase	fprD	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
k59_462809_2	1206741.BAFX01000141_gene2623	4.43e-15	80.9	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,2GK62@201174|Actinobacteria,4FU58@85025|Nocardiaceae	201174|Actinobacteria	KOT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3,Response_reg
k59_1580643_1	1284679.HMPREF1626_10910	8.03e-77	247.0	COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4D4P3@85005|Actinomycetales	201174|Actinobacteria	M	RIP metalloprotease RseP	rip1	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
k59_1463198_1	95619.PM1_0229015	1.28e-112	339.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_759104_1	1348663.KCH_75610	6.18e-99	300.0	COG2072@1|root,COG2072@2|Bacteria,2GMDH@201174|Actinobacteria,2M25K@2063|Kitasatospora	201174|Actinobacteria	P	Flavin-binding monooxygenase-like	-	-	-	-	-	-	-	-	-	-	-	-	FMO-like,K_oxygenase,adh_short
k59_462829_2	1429851.X548_11575	2.8e-54	179.0	COG1131@1|root,COG1131@2|Bacteria,1R3XF@1224|Proteobacteria,1S0MM@1236|Gammaproteobacteria,1X3B4@135614|Xanthomonadales	135614|Xanthomonadales	V	abc transporter atp-binding protein	nodI	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1754814_1	483219.LILAB_20845	1.48e-48	174.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2WJ76@28221|Deltaproteobacteria,2YUHH@29|Myxococcales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_1580658_1	224911.27356169	3.36e-48	169.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,3JR5T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the GMC oxidoreductase family	MA20_19170	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_1463209_1	1307759.JOMJ01000004_gene2449	5.88e-44	150.0	2DENB@1|root,2ZNJM@2|Bacteria	2|Bacteria	S	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_1463210_1	1121372.AULK01000005_gene1573	2.18e-39	139.0	COG1985@1|root,COG1985@2|Bacteria,2GN2P@201174|Actinobacteria,4FNXN@85023|Microbacteriaceae	201174|Actinobacteria	H	RibD C-terminal domain	ribD	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_1699209_1	1051985.l11_06240	4.19e-23	102.0	COG2120@1|root,COG2120@2|Bacteria,1RBZY@1224|Proteobacteria,2W302@28216|Betaproteobacteria	28216|Betaproteobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
k59_1162818_1	1123253.AUBD01000009_gene2221	1.46e-91	278.0	COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,1RNYV@1236|Gammaproteobacteria,1X4ZT@135614|Xanthomonadales	135614|Xanthomonadales	Q	2-keto-4-pentenoate hydratase	uptA	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
k59_1162818_2	1380394.JADL01000012_gene1024	4.68e-28	110.0	COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,2TRFI@28211|Alphaproteobacteria,2JPCP@204441|Rhodospirillales	204441|Rhodospirillales	Q	homogentisate 1,2-dioxygenase	-	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
k59_639050_1	926561.KB900620_gene3204	7.61e-99	311.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,3WAE9@53433|Halanaerobiales	186801|Clostridia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_580196_1	452652.KSE_56400	1.47e-19	92.0	COG1239@1|root,COG1240@1|root,COG1239@2|Bacteria,COG1240@2|Bacteria,2GN3S@201174|Actinobacteria,2M0FC@2063|Kitasatospora	201174|Actinobacteria	H	Magnesium chelatase, subunit ChlI	chlI	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Mg_chelatase,VWA_2
k59_759140_1	977880.RALTA_A1536	9.24e-33	130.0	COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2VNDM@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Spermine/spermidine synthase domain	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
k59_462863_1	530564.Psta_0285	1.72e-30	118.0	COG3591@1|root,COG3591@2|Bacteria	2|Bacteria	E	Belongs to the peptidase S1B family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Trypsin_2
k59_230027_1	349521.HCH_03018	2.29e-49	177.0	COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,1RPGN@1236|Gammaproteobacteria,1XHHM@135619|Oceanospirillales	135619|Oceanospirillales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_230027_2	493475.GARC_2946	3.91e-51	175.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria,464X2@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cusB	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	CusF_Ec,HlyD_D23,HlyD_D4
k59_1582448_2	762983.HMPREF9444_00234	3.74e-08	56.6	COG3160@1|root,COG3160@2|Bacteria,1RHBB@1224|Proteobacteria,1S420@1236|Gammaproteobacteria,1Y4NE@135624|Aeromonadales	135624|Aeromonadales	K	Belongs to the Rsd AlgQ family	-	-	-	ko:K07740	-	-	-	-	ko00000	-	-	-	Rsd_AlgQ
k59_808754_1	247490.KSU1_B0100	4.73e-70	223.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_349440_1	247634.GPB2148_793	2.64e-71	223.0	COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,1RQBF@1236|Gammaproteobacteria,1J62W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the peptidase S11 family	pbpG	GO:0003674,GO:0003824,GO:0004175,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K07262	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
k59_349440_2	261292.Nit79A3_0695	4.73e-08	50.4	2E588@1|root,3300P@2|Bacteria,1N79I@1224|Proteobacteria,2W3RS@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function (DUF5062)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5062
k59_1165601_1	1283283.ATXA01000011_gene4683	6.07e-155	452.0	COG0616@1|root,COG0616@2|Bacteria,2HQDG@201174|Actinobacteria,4ES97@85013|Frankiales	201174|Actinobacteria	OU	PFAM peptidase S49	sppA	-	-	ko:K04773,ko:K04774	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_808769_1	519989.ECTPHS_06547	3.14e-62	201.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales	135613|Chromatiales	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
k59_808769_2	767817.Desgi_4139	1.53e-15	75.9	COG0132@1|root,COG0132@2|Bacteria,1UYA3@1239|Firmicutes,24F15@186801|Clostridia,26262@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	-	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
k59_701272_1	670292.JH26_00425	2.1e-120	350.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,1JTSW@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_1464993_1	933262.AXAM01000050_gene3477	4.3e-36	126.0	COG0727@1|root,COG0727@2|Bacteria,1N3F5@1224|Proteobacteria,42T7I@68525|delta/epsilon subdivisions,2WPNZ@28221|Deltaproteobacteria,2MK3Z@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_1231207_1	472759.Nhal_3463	2.55e-131	379.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1WX13@135613|Chromatiales	135613|Chromatiales	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
k59_1639710_1	1131269.AQVV01000027_gene90	1.98e-55	186.0	COG0579@1|root,COG0579@2|Bacteria	2|Bacteria	S	malate dehydrogenase (menaquinone) activity	lhgO	-	1.1.99.2	ko:K00109,ko:K15736	ko00650,map00650	-	R03534	RC00031	ko00000,ko00001,ko01000	-	-	-	DAO
k59_701276_1	66269.NL54_07725	3e-36	134.0	COG0500@1|root,COG2226@2|Bacteria,1QUBQ@1224|Proteobacteria,1T1S9@1236|Gammaproteobacteria,3W28P@53335|Pantoea	1236|Gammaproteobacteria	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_2
k59_761443_1	270374.MELB17_19314	9.69e-64	205.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,465NF@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105	Glycos_transf_4,MraY_sig1
k59_761443_2	572477.Alvin_0129	4.5e-40	147.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1WWTC@135613|Chromatiales	135613|Chromatiales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1165617_1	1122137.AQXF01000005_gene1288	1.53e-64	214.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,2TSPJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
k59_879850_1	1288494.EBAPG3_2300	1.45e-18	84.0	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,2VH3K@28216|Betaproteobacteria,3733V@32003|Nitrosomonadales	28216|Betaproteobacteria	O	AIR synthase related protein, N-terminal domain	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
k59_761451_1	555778.Hneap_0500	4.14e-144	424.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1WX77@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
k59_641022_1	1396858.Q666_13635	6.53e-34	132.0	COG0438@1|root,COG0438@2|Bacteria,1RKCN@1224|Proteobacteria,1S39F@1236|Gammaproteobacteria,46CMJ@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_641022_2	981336.F944_02971	2.74e-44	159.0	COG3660@1|root,COG3660@2|Bacteria,1N2B1@1224|Proteobacteria,1S9UI@1236|Gammaproteobacteria,3NMPQ@468|Moraxellaceae	1236|Gammaproteobacteria	M	Mitochondrial fission ELM1	-	-	-	-	-	-	-	-	-	-	-	-	Mito_fiss_Elm1
k59_582084_1	296591.Bpro_2164	2.84e-113	338.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VIYF@28216|Betaproteobacteria,4AAS7@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM carboxyl transferase	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1756814_1	713586.KB900536_gene466	0.000475	42.7	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria	1224|Proteobacteria	P	sulfurtransferase	rhdA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_1756814_2	572477.Alvin_1530	3.03e-22	96.3	COG0394@1|root,COG0640@1|root,COG0394@2|Bacteria,COG0640@2|Bacteria,1MWYQ@1224|Proteobacteria,1S2YD@1236|Gammaproteobacteria,1WY4X@135613|Chromatiales	135613|Chromatiales	T	low molecular weight	-	-	1.20.4.1	ko:K03741,ko:K03892	-	-	-	-	ko00000,ko01000,ko03000	-	-	-	HTH_5,LMWPc
k59_1053686_1	1535422.ND16A_2157	2.9e-29	121.0	COG3591@1|root,COG3591@2|Bacteria,1R8XR@1224|Proteobacteria,1RZT2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the peptidase S1B family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1582510_1	391008.Smal_0501	1.64e-27	107.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,1RMK7@1236|Gammaproteobacteria,1X4RW@135614|Xanthomonadales	135614|Xanthomonadales	C	Electron transfer flavoprotein	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
k59_1582510_2	1265313.HRUBRA_01443	7.6e-28	113.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,1RPGT@1236|Gammaproteobacteria,1J7GA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Acetyl-coenzyme A synthetase N-terminus	acsA	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_701332_1	1304865.JAGF01000001_gene1607	8.41e-149	445.0	COG1080@1|root,COG1080@2|Bacteria,2GIZZ@201174|Actinobacteria	201174|Actinobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.1.202,2.7.3.9	ko:K02768,ko:K08483,ko:K11183	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PPDK_N,PTS-HPr,PTS_EIIA_1
k59_1053714_1	744985.HIMB59_00009930	7.05e-94	299.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2TVZI@28211|Alphaproteobacteria,4BPQG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Formate dehydrogenase, alpha subunit	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1639749_1	1120950.KB892816_gene7175	4.25e-10	66.2	COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_232299_1	1279017.AQYJ01000027_gene1917	7.36e-67	213.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,1RPMP@1236|Gammaproteobacteria,466UT@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1	mip	-	5.2.1.8	ko:K03772,ko:K03773	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
k59_1165709_1	68223.JNZY01000042_gene5966	6.51e-12	66.6	COG1595@1|root,COG1595@2|Bacteria,2IJEM@201174|Actinobacteria	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_465542_1	713586.KB900536_gene1027	3.51e-58	192.0	COG3439@1|root,COG3439@2|Bacteria,1MXYT@1224|Proteobacteria,1SAK5@1236|Gammaproteobacteria,1X0WH@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_701354_1	204669.Acid345_4083	2.67e-23	105.0	COG1195@1|root,COG3593@1|root,COG1195@2|Bacteria,COG3593@2|Bacteria,3Y7ZQ@57723|Acidobacteria	57723|Acidobacteria	L	Protein of unknown function (DUF2813)	-	-	-	ko:K07459	-	-	-	-	ko00000	-	-	-	DUF2813
k59_1231296_1	391937.NA2_01090	4.55e-96	303.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,43HUP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the GcvT family	dmgdh2	-	1.5.8.4	ko:K00315	ko00260,ko01100,map00260,map01100	-	R01565	RC00181	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
k59_1231300_1	471853.Bcav_0657	3.33e-72	241.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2GJU7@201174|Actinobacteria	201174|Actinobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
k59_808844_1	945713.IALB_0163	4.37e-107	332.0	COG0525@1|root,COG0525@2|Bacteria	2|Bacteria	J	valine-tRNA ligase activity	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iLJ478.TM1817	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_1756874_1	1095769.CAHF01000010_gene1325	7.14e-85	266.0	COG0438@1|root,COG0438@2|Bacteria,1MVIM@1224|Proteobacteria,2VJT7@28216|Betaproteobacteria,473D4@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Glycosyl transferases group 1	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
k59_232323_1	1184609.KILIM_033_00100	3.41e-30	119.0	COG3879@1|root,COG3879@2|Bacteria,2GJ3C@201174|Actinobacteria,4F7V0@85018|Dermatophilaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF881)	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF881
k59_174521_1	1286106.MPL1_02488	1.75e-54	184.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria,461QK@72273|Thiotrichales	72273|Thiotrichales	K	PFAM Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
k59_641099_1	1206737.BAGF01000150_gene6090	4.92e-25	99.4	29VYI@1|root,30HGP@2|Bacteria,2H6WY@201174|Actinobacteria,4G3BU@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1813554_1	96561.Dole_1204	9.35e-82	259.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WUG9@28221|Deltaproteobacteria,2MMW2@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_233829_1	795666.MW7_2482	1.14e-19	92.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2VH64@28216|Betaproteobacteria,1K0NI@119060|Burkholderiaceae	28216|Betaproteobacteria	H	receptor	btuB	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	Plug,TonB_dep_Rec
k59_233829_2	743721.Psesu_0598	1.35e-23	94.4	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,1S40D@1236|Gammaproteobacteria,1X50D@135614|Xanthomonadales	135614|Xanthomonadales	S	adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
k59_351152_1	452637.Oter_2678	3.96e-78	255.0	COG0542@1|root,COG0542@2|Bacteria,46SD6@74201|Verrucomicrobia,3K7MH@414999|Opitutae	414999|Opitutae	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
k59_233832_1	96561.Dole_2782	3.09e-30	116.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2WJAZ@28221|Deltaproteobacteria,2MHTR@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_1167683_1	1345695.CLSA_c16810	0.000723	45.1	COG0500@1|root,COG2226@2|Bacteria,1VAEA@1239|Firmicutes,24G83@186801|Clostridia,36I0B@31979|Clostridiaceae	186801|Clostridia	Q	PFAM ubiE COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31,Ubie_methyltran
k59_809985_1	1192034.CAP_6959	1.07e-37	143.0	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,42P4E@68525|delta/epsilon subdivisions,2WN09@28221|Deltaproteobacteria,2YUZJ@29|Myxococcales	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
k59_642510_2	1165841.SULAR_02478	7.24e-15	74.3	COG5276@1|root,COG5276@2|Bacteria,1NTT8@1224|Proteobacteria,42ZD4@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
k59_1055815_1	1304865.JAGF01000001_gene2040	7.63e-153	439.0	COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria,4F204@85016|Cellulomonadaceae	201174|Actinobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_642511_1	348824.LPU83_3737	2.75e-161	487.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,4B8TD@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	efflux pump	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1232809_1	76114.ebA4159	2.33e-08	57.0	COG3090@1|root,COG3090@2|Bacteria,1R3YK@1224|Proteobacteria,2VQMP@28216|Betaproteobacteria,2KVXN@206389|Rhodocyclales	206389|Rhodocyclales	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	ko:K11689	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
k59_1232809_2	156889.Mmc1_2139	2.59e-49	167.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TS46@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	dctP	-	-	ko:K11688	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
k59_1758251_1	631362.Thi970DRAFT_00375	4.65e-101	305.0	COG0786@1|root,COG0786@2|Bacteria,1MVBC@1224|Proteobacteria,1RP0S@1236|Gammaproteobacteria,1WXWV@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the sodium-dependent transport of glutamate	-	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
k59_233868_1	1384054.N790_04740	6.55e-103	311.0	COG3844@1|root,COG3844@2|Bacteria,1MUKN@1224|Proteobacteria,1RPY3@1236|Gammaproteobacteria,1X3FQ@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016822,GO:0016823,GO:0019439,GO:0019441,GO:0019752,GO:0030429,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
k59_583243_2	1144305.PMI02_00868	2.51e-08	57.4	COG2267@1|root,COG2267@2|Bacteria,1QWF2@1224|Proteobacteria,2TWXU@28211|Alphaproteobacteria,2KB51@204457|Sphingomonadales	204457|Sphingomonadales	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_642552_1	1122599.AUGR01000001_gene376	5.12e-87	269.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1XHP0@135619|Oceanospirillales	135619|Oceanospirillales	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
k59_233894_1	522306.CAP2UW1_2438	9.53e-102	318.0	COG4196@1|root,COG4196@2|Bacteria,1R6II@1224|Proteobacteria,2WHVK@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Putative amidoligase enzyme (DUF2126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2126
k59_642553_1	590998.Celf_0990	7.25e-47	177.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,2GKCX@201174|Actinobacteria	201174|Actinobacteria	K	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12
k59_1640832_1	95619.PM1_0204750	1.8e-82	263.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_1055910_1	1111728.ATYS01000001_gene2320	2.93e-19	82.4	COG0818@1|root,COG0818@2|Bacteria,1MZ3Q@1224|Proteobacteria,1S92I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Recycling of diacylglycerol produced during the turnover of membrane phospholipid	dgkA	GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006654,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046473,GO:0046474,GO:0046486,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.1.107	ko:K00901	ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_prokar
k59_351225_1	96561.Dole_2310	7.38e-99	300.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,42M94@68525|delta/epsilon subdivisions,2WINB@28221|Deltaproteobacteria,2MHWE@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_467597_1	1150469.RSPPHO_02821	8.41e-43	154.0	COG0679@1|root,COG0679@2|Bacteria,1N1X9@1224|Proteobacteria,2TV2I@28211|Alphaproteobacteria,2JRYA@204441|Rhodospirillales	204441|Rhodospirillales	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
k59_467597_2	765912.Thimo_1897	1.29e-55	181.0	28QMK@1|root,2ZD39@2|Bacteria,1RAWM@1224|Proteobacteria,1S2FU@1236|Gammaproteobacteria,1WY0Y@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_467597_3	631362.Thi970DRAFT_00491	4.62e-32	118.0	COG3128@1|root,COG3128@2|Bacteria,1MUI7@1224|Proteobacteria,1RQ0M@1236|Gammaproteobacteria,1WX61@135613|Chromatiales	135613|Chromatiales	S	PKHD-type hydroxylase	-	-	-	ko:K07336	-	-	-	-	ko00000,ko01000	-	-	-	2OG-FeII_Oxy_3
k59_1055962_1	1035308.AQYY01000001_gene1812	5.33e-85	268.0	COG4325@1|root,COG4325@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
k59_702919_1	1128421.JAGA01000003_gene3593	2.47e-06	55.1	COG1129@1|root,COG4585@1|root,COG1129@2|Bacteria,COG4585@2|Bacteria,2NPR8@2323|unclassified Bacteria	2|Bacteria	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	2.1.1.80,3.1.1.61,3.6.3.17	ko:K02056,ko:K13924	ko02020,ko02030,map02020,map02030	M00221,M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02000,ko02022,ko02035	3.A.1.2	-	-	ABC_tran,HATPase_c,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,SBP_bac_3
k59_1466312_2	224324.aq_402	4.83e-38	133.0	COG0509@1|root,COG0509@2|Bacteria	2|Bacteria	E	glycine decarboxylation via glycine cleavage system	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
k59_1583768_1	83406.HDN1F_08500	2.43e-121	355.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,1RNQ4@1236|Gammaproteobacteria,1J4MG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily	adhC	GO:0003674,GO:0003824,GO:0004022,GO:0004024,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009636,GO:0009987,GO:0010033,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017001,GO:0017144,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046292,GO:0046294,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0051903,GO:0055114,GO:0070887,GO:0071704,GO:0097237,GO:0098754,GO:0110095,GO:0110096,GO:1901575,GO:1901700,GO:1901701,GO:1990748	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	iEC042_1314.EC042_0393,iEC55989_1330.EC55989_0365,iECH74115_1262.ECH74115_0431,iECIAI1_1343.ECIAI1_0357,iECIAI39_1322.ECIAI39_0322,iECO103_1326.ECO103_0338,iECO111_1330.ECO111_0392,iECO26_1355.ECO26_0392,iECSE_1348.ECSE_0381,iECSP_1301.ECSP_0420,iECUMN_1333.ECUMN_0399,iECW_1372.ECW_m0434,iECs_1301.ECs0411,iEKO11_1354.EKO11_3486,iETEC_1333.ETEC_0412,iEcE24377_1341.EcE24377A_0381,iEcHS_1320.EcHS_A0421,iEcolC_1368.EcolC_3269,iG2583_1286.G2583_0469,iSSON_1240.SSON_0335,iSbBS512_1146.SbBS512_E0271,iUMNK88_1353.UMNK88_407,iWFL_1372.ECW_m0434,iZ_1308.Z0456	ADH_N,ADH_zinc_N
k59_1055979_1	290340.AAur_0768	1.62e-27	109.0	2BDAC@1|root,326YU@2|Bacteria,2HCIT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1167857_2	1121372.AULK01000002_gene733	7.03e-47	154.0	COG2764@1|root,COG2764@2|Bacteria,2IN3F@201174|Actinobacteria,4FPUQ@85023|Microbacteriaceae	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt,Glyoxalase
k59_1813743_1	590998.Celf_1121	1.52e-09	60.5	COG0580@1|root,COG0580@2|Bacteria,2GKK3@201174|Actinobacteria,4F0YW@85016|Cellulomonadaceae	201174|Actinobacteria	G	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
k59_1813743_2	1123242.JH636435_gene2208	2.62e-08	62.4	COG4299@1|root,COG4299@2|Bacteria,2J1X5@203682|Planctomycetes	203682|Planctomycetes	S	COGs COG4299 conserved	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1167860_2	545276.KB898725_gene762	1.34e-58	194.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WXBN@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD linked oxidase domain protein	-	-	1.1.5.12	ko:K03777	ko00620,ko01120,map00620,map01120	-	R00704,R11591	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1758339_1	446469.Sked_27470	7.08e-63	216.0	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria	201174|Actinobacteria	T	UPF0182 protein	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_233986_1	471853.Bcav_1744	5.66e-125	374.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria	201174|Actinobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_702965_1	471853.Bcav_3270	1.1e-113	330.0	COG0569@1|root,COG0569@2|Bacteria,2IA09@201174|Actinobacteria	201174|Actinobacteria	P	domain protein	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_1171649_2	715451.ambt_00065	6.71e-39	144.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,465DD@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1171662_1	929712.KI912613_gene4449	1.34e-08	57.4	COG0604@1|root,COG0604@2|Bacteria,2GRJM@201174|Actinobacteria	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
k59_1643501_1	305700.B447_17918	1.58e-82	272.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,2KUXH@206389|Rhodocyclales	206389|Rhodocyclales	EF	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_586044_2	765912.Thimo_1159	3.82e-78	243.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria,1WXIF@135613|Chromatiales	135613|Chromatiales	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_586064_1	1122931.AUAE01000006_gene3146	9.94e-15	79.7	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P2A4@976|Bacteroidetes,2FXBE@200643|Bacteroidia	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
k59_1171706_4	472759.Nhal_0963	3.84e-17	79.3	COG3378@1|root,COG3378@2|Bacteria,1QVIS@1224|Proteobacteria,1S02S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Psort location Cytoplasmic, score	-	-	-	ko:K06919	-	-	-	-	ko00000	-	-	-	Prim-Pol,Toprim_3,Toprim_4
k59_526660_1	930171.Asphe3_35030	2.33e-38	137.0	COG3836@1|root,COG3836@2|Bacteria,2HGEA@201174|Actinobacteria,1W82F@1268|Micrococcaceae	201174|Actinobacteria	G	Belongs to the HpcH HpaI aldolase family	hpaI	-	4.1.2.52,4.1.2.53	ko:K02510,ko:K12660	ko00051,ko00350,ko01120,map00051,map00350,map01120	-	R01645,R01647,R02261	RC00307,RC00435,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
k59_526660_2	1179773.BN6_34240	2.51e-09	56.6	COG3384@1|root,COG3384@2|Bacteria,2GT9G@201174|Actinobacteria,4E9EI@85010|Pseudonocardiales	201174|Actinobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	1.13.11.15	ko:K00455	ko00350,ko01120,ko01220,map00350,map01120,map01220	M00533	R03303	RC00643	ko00000,ko00001,ko00002,ko01000	-	-	-	LigB
k59_526669_1	1056820.KB900674_gene2544	2.61e-44	150.0	COG0071@1|root,COG0071@2|Bacteria,1RH2X@1224|Proteobacteria,1S6WS@1236|Gammaproteobacteria,2PNHV@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	O	Hsp20/alpha crystallin family	ibpA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896	-	ko:K04080	-	-	-	-	ko00000,ko03110	-	-	-	HSP20
k59_526669_2	765910.MARPU_02510	8.9e-87	270.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1WX0Q@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
k59_1643555_1	590998.Celf_2505	6.58e-86	262.0	COG1091@1|root,COG1091@2|Bacteria,2GNY8@201174|Actinobacteria,4F24G@85016|Cellulomonadaceae	201174|Actinobacteria	M	Male sterility protein	rmlD	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
k59_1643567_1	1255043.TVNIR_3124	1.01e-36	133.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,1S2ET@1236|Gammaproteobacteria,1WWDD@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_1817318_1	96561.Dole_1517	4.27e-12	62.8	COG0375@1|root,COG0375@2|Bacteria,1PTY5@1224|Proteobacteria,42U07@68525|delta/epsilon subdivisions,2WPIB@28221|Deltaproteobacteria,2MKDV@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
k59_1817318_2	96561.Dole_0298	2.45e-88	266.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,42MMJ@68525|delta/epsilon subdivisions,2WK7X@28221|Deltaproteobacteria,2MIJ1@213118|Desulfobacterales	28221|Deltaproteobacteria	KO	TIGRFAM hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
k59_586145_1	743718.Isova_0749	2.66e-140	410.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,2GK3B@201174|Actinobacteria,4F45D@85017|Promicromonosporaceae	201174|Actinobacteria	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	cobA	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,TP_methylase
k59_526716_1	1500306.JQLA01000052_gene3084	8.06e-09	58.5	COG2199@1|root,COG2199@2|Bacteria,1NV1F@1224|Proteobacteria,2TWWY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_526716_2	349124.Hhal_1922	3.03e-44	154.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,1RMDF@1236|Gammaproteobacteria,1WWFW@135613|Chromatiales	135613|Chromatiales	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
k59_586163_1	485915.Dret_1796	3.28e-64	213.0	COG0569@1|root,COG0589@1|root,COG0569@2|Bacteria,COG0589@2|Bacteria,1QZ59@1224|Proteobacteria,43CFV@68525|delta/epsilon subdivisions,2WR2F@28221|Deltaproteobacteria,2M9AU@213115|Desulfovibrionales	28221|Deltaproteobacteria	PT	TrkA-N domain	-	-	-	ko:K03499,ko:K09944	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N,Usp
k59_1171795_1	1499686.BN1079_03205	7.97e-106	311.0	2CH0A@1|root,2ZANK@2|Bacteria,1R6U4@1224|Proteobacteria,1RQ3J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1817373_1	1288826.MSNKSG1_14512	1.82e-15	75.9	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,467HG@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iSF_1195.SF3815,iSFxv_1172.SFxv_4157,iS_1188.S3953	OSCP
k59_1817373_2	1132855.KB913035_gene228	3.07e-12	63.9	COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,2VRMS@28216|Betaproteobacteria,2KMJT@206350|Nitrosomonadales	206350|Nitrosomonadales	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
k59_526777_1	1123393.KB891326_gene24	3.28e-35	134.0	28K74@1|root,2Z9VA@2|Bacteria,1R8MQ@1224|Proteobacteria,2W7WR@28216|Betaproteobacteria,1KSWK@119069|Hydrogenophilales	119069|Hydrogenophilales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_526777_2	1123401.JHYQ01000003_gene2122	8.31e-45	159.0	COG0028@1|root,COG0028@2|Bacteria,1MWVW@1224|Proteobacteria,1SN0M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1817386_1	390235.PputW619_4324	2.67e-105	317.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1YWK1@136845|Pseudomonas putida group	1236|Gammaproteobacteria	J	histidyl-tRNA synthetase	hisS	GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358	HGTP_anticodon,tRNA-synt_His
k59_526795_2	290512.Paes_2160	4.68e-18	84.7	28I8B@1|root,2Z8B5@2|Bacteria,1FDFC@1090|Chlorobi	1090|Chlorobi	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_cB
k59_1643671_1	340177.Cag_0614	7.6e-20	94.0	COG1357@1|root,COG2931@1|root,COG3210@1|root,COG4625@1|root,COG1357@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria	2|Bacteria	T	pathogenesis	rhgB	-	4.2.2.23	ko:K07004,ko:K18195	-	-	-	-	ko00000,ko01000	-	PL4	-	CBM-like,RhgB_N,fn3_3
k59_586298_1	1244869.H261_05844	2.07e-19	85.9	COG1143@1|root,COG1145@1|root,COG1143@2|Bacteria,COG1145@2|Bacteria,1QWGE@1224|Proteobacteria	1224|Proteobacteria	C	4Fe-4S binding domain	-	-	-	ko:K02573	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4,Fer4_7
k59_880592_1	1193181.BN10_130070	5.68e-85	259.0	COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria,4FE5G@85021|Intrasporangiaceae	201174|Actinobacteria	E	ABC transporter	glnQ	-	3.6.3.21	ko:K02028,ko:K17076	ko02010,map02010	M00236,M00589	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.20	-	-	ABC_tran
k59_1761164_1	1121413.JMKT01000008_gene1587	6.27e-25	100.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,2M8CK@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	qrcC	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
k59_1761164_2	882.DVU_0692	9.38e-22	94.0	COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42N47@68525|delta/epsilon subdivisions,2WIKZ@28221|Deltaproteobacteria,2M8JX@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Polysulphide reductase, NrfD	qrcD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_1526345_1	1286093.C266_15866	2.62e-120	354.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,1K1ZW@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_821885_1	717785.HYPMC_0100	1.54e-56	192.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR78@28211|Alphaproteobacteria,3N6XV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	PFAM acyl-CoA dehydrogenase	mcd	-	1.3.8.12	ko:K14448	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09293	RC02483	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1350231_1	1379698.RBG1_1C00001G0297	1.35e-23	99.0	COG4881@1|root,COG4881@2|Bacteria	2|Bacteria	-	-	cbcU	-	-	-	-	-	-	-	-	-	-	-	NrfD
k59_1350231_2	1379698.RBG1_1C00001G0296	5.57e-62	196.0	COG0437@1|root,COG0437@2|Bacteria,2NR78@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S binding domain	ttrB	-	-	ko:K08358	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10150	RC03109	ko00000,ko00001,ko02000	5.A.3.10	-	-	Fer4_11,Fer4_3,Fer4_7
k59_117419_1	290399.Arth_3205	2.41e-58	194.0	COG0438@1|root,COG0438@2|Bacteria,2GJI0@201174|Actinobacteria,1WC02@1268|Micrococcaceae	201174|Actinobacteria	H	Glycosyl transferases group 1	wcnD	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_939302_1	1144275.COCOR_04924	3.91e-14	76.3	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	1.8.1.9	ko:K00384,ko:K04739,ko:K07001,ko:K10914	ko00450,ko02020,ko02024,ko02025,ko02026,ko04910,ko05111,map00450,map02020,map02024,map02025,map02026,map04910,map05111	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03000	-	-	-	cNMP_binding
k59_58721_2	489825.LYNGBM3L_21180	1.81e-57	191.0	COG0438@1|root,COG0438@2|Bacteria,1GCX5@1117|Cyanobacteria	1117|Cyanobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_352257_1	713586.KB900536_gene968	1.39e-47	165.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,1WWXY@135613|Chromatiales	135613|Chromatiales	S	Permease YjgP YjgQ	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_352257_2	1429851.X548_01215	2.7e-16	75.1	COG1714@1|root,COG1714@2|Bacteria,1N7R6@1224|Proteobacteria,1SCCT@1236|Gammaproteobacteria,1X706@135614|Xanthomonadales	135614|Xanthomonadales	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
k59_1526353_1	1386089.N865_10240	3.08e-64	199.0	COG0335@1|root,COG0335@2|Bacteria,2IHRT@201174|Actinobacteria,4FGSF@85021|Intrasporangiaceae	201174|Actinobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
k59_939323_2	1249627.D779_2944	3.39e-25	99.0	COG0636@1|root,COG0636@2|Bacteria,1N5D3@1224|Proteobacteria,1SBV1@1236|Gammaproteobacteria,1WZ48@135613|Chromatiales	135613|Chromatiales	U	Belongs to the V-ATPase proteolipid subunit family	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
k59_939323_3	768671.ThimaDRAFT_4701	1.37e-25	107.0	COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria,1WX8D@135613|Chromatiales	135613|Chromatiales	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_1643777_1	1384054.N790_13605	3.31e-09	57.8	COG1015@1|root,COG1015@2|Bacteria,1MVN8@1224|Proteobacteria,1RQ6W@1236|Gammaproteobacteria,1X4FW@135614|Xanthomonadales	135614|Xanthomonadales	G	Phosphotransfer between the C1 and C5 carbon atoms of pentose	deoB	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
k59_1643777_2	1122137.AQXF01000005_gene1198	1.82e-16	81.3	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,2TS24@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis	deoA	-	2.4.2.4	ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
k59_939326_1	367299.JOEE01000002_gene2365	2.08e-46	153.0	COG0717@1|root,COG0717@2|Bacteria,2GKQQ@201174|Actinobacteria,4FF90@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the dCTP deaminase family	dcd	GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
k59_939326_2	1184609.KILIM_057_00070	7.83e-07	52.0	COG2267@1|root,COG2267@2|Bacteria,2I3AW@201174|Actinobacteria,4F7VP@85018|Dermatophilaceae	201174|Actinobacteria	I	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4,Peptidase_S9
k59_1819901_1	493475.GARC_2471	1.13e-37	135.0	COG3339@1|root,COG3339@2|Bacteria,1RAN7@1224|Proteobacteria,1S291@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Conserved Protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
k59_1819901_2	1123253.AUBD01000001_gene1904	4.84e-43	149.0	COG0491@1|root,COG0491@2|Bacteria,1R4FA@1224|Proteobacteria,1S1QD@1236|Gammaproteobacteria,1X36I@135614|Xanthomonadales	135614|Xanthomonadales	S	metallo-beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_58741_1	710696.Intca_1139	1.39e-60	204.0	COG4584@1|root,COG4584@2|Bacteria,2GM4J@201174|Actinobacteria,4FFND@85021|Intrasporangiaceae	201174|Actinobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_58741_2	710696.Intca_1138	1.76e-107	317.0	COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria	201174|Actinobacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_587086_1	396588.Tgr7_2124	2.72e-93	305.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1WWH2@135613|Chromatiales	135613|Chromatiales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_293557_1	335543.Sfum_3327	2.51e-29	123.0	COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,42NVY@68525|delta/epsilon subdivisions,2WKWM@28221|Deltaproteobacteria,2MS2I@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
k59_1115436_1	335543.Sfum_0364	4.32e-78	249.0	COG1061@1|root,COG1061@2|Bacteria,1QWMJ@1224|Proteobacteria,42NXF@68525|delta/epsilon subdivisions,2WJWA@28221|Deltaproteobacteria,2MRP4@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Type III restriction enzyme, res subunit	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,ResIII
k59_1291572_1	1496688.ER33_12255	1.16e-28	112.0	COG3806@1|root,COG3806@2|Bacteria,1G0B3@1117|Cyanobacteria,22SCW@167375|Cyanobium	1117|Cyanobacteria	T	ChrR Cupin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
k59_60_1	1040983.AXAE01000023_gene23	6.39e-46	162.0	COG0459@1|root,COG0459@2|Bacteria,1PMNK@1224|Proteobacteria,2TTPT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_60_2	366602.Caul_0473	1.02e-47	163.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2TSJN@28211|Alphaproteobacteria,2KF1K@204458|Caulobacterales	204458|Caulobacterales	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k59_352284_1	314345.SPV1_08346	2.48e-56	191.0	COG3202@1|root,COG3202@2|Bacteria,1RCHN@1224|Proteobacteria	1224|Proteobacteria	P	Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism	tlc4	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015931,GO:0016020,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	TLC
k59_410977_1	34506.g2356	1.99e-31	125.0	COG0294@1|root,COG1109@1|root,KOG1220@2759|Eukaryota,KOG2544@2759|Eukaryota,38WEB@33154|Opisthokonta,3C72M@33208|Metazoa,3DRE6@33213|Bilateria,40P6G@6231|Nematoda,1M6NG@119089|Chromadorea,4152Z@6236|Rhabditida	33208|Metazoa	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II	-	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
k59_704507_1	247490.KSU1_D0232	5.43e-12	65.5	COG1694@1|root,COG3956@2|Bacteria,2IZXZ@203682|Planctomycetes	203682|Planctomycetes	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	ko:K02499	-	-	-	-	ko00000,ko03036	-	-	-	MazG
k59_704507_2	880072.Desac_0716	9.85e-08	54.7	COG4191@1|root,COG4191@2|Bacteria,1RI33@1224|Proteobacteria,42SUG@68525|delta/epsilon subdivisions,2WP3A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	bamV	-	2.7.13.3	ko:K10125	ko02020,map02020	M00504	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,dCache_1
k59_1056741_1	1396141.BATP01000020_gene17	3.52e-114	337.0	COG4313@1|root,COG4313@2|Bacteria,46UHV@74201|Verrucomicrobia,2IVEU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
k59_58758_1	207559.Dde_1917	1.13e-06	48.9	28MBT@1|root,2ZAQ7@2|Bacteria,1NXN9@1224|Proteobacteria,42NZE@68525|delta/epsilon subdivisions,2WM60@28221|Deltaproteobacteria,2M9NB@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1291588_1	583355.Caka_2045	2.25e-08	61.6	COG0771@1|root,COG2911@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	murD	-	3.4.21.10,6.3.2.13,6.3.2.9	ko:K01317,ko:K01925,ko:K01928,ko:K01932	ko00300,ko00471,ko00550,ko01100,map00300,map00471,map00550,map01100	-	R02783,R02788	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01002,ko01011,ko04131	-	-	-	DUF1727,Mur_ligase_C,Mur_ligase_M
k59_1643795_1	1123267.JONN01000001_gene1238	3.74e-92	300.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,MRJP
k59_1702502_1	1380370.JIBA01000014_gene1858	6.2e-120	347.0	COG1177@1|root,COG1177@2|Bacteria,2GJ6Q@201174|Actinobacteria,4FEZB@85021|Intrasporangiaceae	201174|Actinobacteria	E	COG1177 ABC-type spermidine putrescine transport system, permease component II	-	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
k59_821932_1	439235.Dalk_0092	2.27e-57	204.0	COG1413@1|root,COG2199@1|root,COG3899@1|root,COG1413@2|Bacteria,COG2199@2|Bacteria,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	cpeY	-	2.7.11.1,2.7.7.65	ko:K05385,ko:K12132,ko:K13590	ko00196,ko01100,ko04112,map00196,map01100,map04112	-	-	-	ko00000,ko00001,ko00194,ko01000,ko01001	-	-	-	AAA_16,EAL,GGDEF,Trans_reg_C
k59_1526375_2	517418.Ctha_2557	9.91e-12	68.9	COG1009@1|root,COG1009@2|Bacteria,1FDAG@1090|Chlorobi	1090|Chlorobi	C	PFAM NADH-Ubiquinone oxidoreductase (complex I), chain 5 L domain protein	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_469695_2	498211.CJA_2802	1.95e-11	67.8	COG3117@1|root,COG3117@2|Bacteria,1NGCC@1224|Proteobacteria,1SGDP@1236|Gammaproteobacteria,1FHMZ@10|Cellvibrio	1236|Gammaproteobacteria	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA	lptC	-	-	ko:K11719	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC
k59_469695_3	1027273.GZ77_20140	3.84e-12	65.9	COG1934@1|root,COG1934@2|Bacteria,1N776@1224|Proteobacteria,1RPM7@1236|Gammaproteobacteria,1XMAP@135619|Oceanospirillales	135619|Oceanospirillales	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
k59_528405_1	768671.ThimaDRAFT_0226	2.49e-47	165.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,1WVZV@135613|Chromatiales	135613|Chromatiales	P	PFAM Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_1643807_1	1121405.dsmv_0179	5.04e-42	145.0	COG1573@1|root,COG1573@2|Bacteria,1PIX8@1224|Proteobacteria,42P41@68525|delta/epsilon subdivisions,2WM40@28221|Deltaproteobacteria,2MN8M@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM Uracil-DNA glycosylase superfamily	-	-	-	ko:K10800	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_998065_1	883.DvMF_2079	2.99e-43	158.0	COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria,2M7RB@213115|Desulfovibrionales	28221|Deltaproteobacteria	GM	NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
k59_410995_1	593907.Celgi_2274	8.6e-37	136.0	COG4632@1|root,COG4632@2|Bacteria,2HXYQ@201174|Actinobacteria,4F1U7@85016|Cellulomonadaceae	201174|Actinobacteria	G	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA
k59_410995_2	1211815.CBYP010000044_gene349	5.54e-98	292.0	COG2356@1|root,COG2356@2|Bacteria,2GJ38@201174|Actinobacteria,4ESGG@85013|Frankiales	201174|Actinobacteria	L	Protein of unknown function (DUF1524)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1524,Excalibur
k59_469697_1	391615.ABSJ01000038_gene400	1.22e-54	178.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1J51Q@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	exodeoxyribonuclease III	crc	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_469697_2	1197719.A464_3810	7.04e-47	157.0	COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria,3ZJVS@590|Salmonella	1236|Gammaproteobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	GO:0000287,GO:0003674,GO:0003824,GO:0004588,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_2819,iECIAI39_1322.ECIAI39_4161,iEcSMS35_1347.EcSMS35_3977,iUTI89_1310.UTI89_C4186	Pribosyltran
k59_469702_1	765911.Thivi_1779	1.91e-116	352.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1RSFG@1236|Gammaproteobacteria,1WW9R@135613|Chromatiales	135613|Chromatiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_411001_1	880072.Desac_2441	1.83e-41	147.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,42MY6@68525|delta/epsilon subdivisions,2WMDC@28221|Deltaproteobacteria,2MREJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Alcohol dehydrogenase	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_881609_1	765910.MARPU_14265	3.77e-91	286.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,1WX75@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_998619_1	570967.JMLV01000001_gene2554	2.01e-27	103.0	COG0394@1|root,COG0394@2|Bacteria,1RANV@1224|Proteobacteria,2U5EE@28211|Alphaproteobacteria,2JS65@204441|Rhodospirillales	204441|Rhodospirillales	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
k59_998619_2	196490.AUEZ01000058_gene1075	3.06e-68	211.0	COG5328@1|root,COG5328@2|Bacteria,1RA93@1224|Proteobacteria,2U741@28211|Alphaproteobacteria,3JTW9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0262 family	MA20_21090	-	-	-	-	-	-	-	-	-	-	-	UPF0262
k59_411436_1	590998.Celf_1077	2.71e-113	332.0	COG1349@1|root,COG1349@2|Bacteria,2GKWM@201174|Actinobacteria,4F32F@85016|Cellulomonadaceae	201174|Actinobacteria	K	DeoR C terminal sensor domain	fruR	-	-	ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
k59_822486_1	713587.THITH_16595	5.4e-45	155.0	COG0398@1|root,COG0607@1|root,COG0398@2|Bacteria,COG0607@2|Bacteria,1MVF3@1224|Proteobacteria,1RSK1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	SNARE associated Golgi protein	ydjX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Rhodanese,SNARE_assoc
k59_822486_2	1049564.TevJSym_ae00650	3.3e-77	237.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,1RQJQ@1236|Gammaproteobacteria,1J5P9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_1292480_1	335543.Sfum_0461	6.15e-155	453.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,43BUE@68525|delta/epsilon subdivisions,2X75I@28221|Deltaproteobacteria,2MQ9C@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Conserved carboxylase domain	oadA	-	2.1.3.1,4.1.1.3,6.4.1.1	ko:K01571,ko:K01960,ko:K03416	ko00020,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00640,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344,R00353,R00930	RC00040,RC00097,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_705037_1	393921.HQ45_04245	2.01e-33	127.0	COG1752@1|root,COG1752@2|Bacteria,4NISG@976|Bacteroidetes	976|Bacteroidetes	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_353234_1	472759.Nhal_3534	4.48e-101	313.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1WXKA@135613|Chromatiales	135613|Chromatiales	G	PFAM Alpha amylase, catalytic	-	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_353244_1	1304275.C41B8_05118	3.83e-12	67.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1T07D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Heat shock protein HtpX	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_940333_1	1313172.YM304_24430	2.4e-102	300.0	COG0778@1|root,COG0778@2|Bacteria,2HI8Q@201174|Actinobacteria	201174|Actinobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_1820863_1	439235.Dalk_4743	4.5e-77	251.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,2MIS9@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_59732_1	1163617.SCD_n02015	2.08e-08	54.7	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2VHPW@28216|Betaproteobacteria	28216|Betaproteobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_59732_2	323261.Noc_2631	1.38e-55	183.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,1WX40@135613|Chromatiales	135613|Chromatiales	EH	PFAM Aminotransferase, class IV	-	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
k59_998638_1	644107.SL1157_3075	1.38e-35	128.0	COG2391@1|root,COG2391@2|Bacteria,1RIWE@1224|Proteobacteria,2U4F1@28211|Alphaproteobacteria,4ND6X@97050|Ruegeria	28211|Alphaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_763727_1	395493.BegalDRAFT_2525	3.24e-35	139.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,463KB@72273|Thiotrichales	72273|Thiotrichales	M	PFAM Transglycosylase SLT domain	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
k59_705047_1	754477.Q7C_1240	5.51e-54	183.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,4604E@72273|Thiotrichales	72273|Thiotrichales	JKL	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_176679_1	335543.Sfum_2525	3.33e-51	176.0	COG0568@1|root,COG0568@2|Bacteria,1MXGX@1224|Proteobacteria,42PIS@68525|delta/epsilon subdivisions,2WKSS@28221|Deltaproteobacteria,2MQYD@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_998641_1	314287.GB2207_02717	1.85e-16	75.1	COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,1SD1K@1236|Gammaproteobacteria,1J702@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TerB
k59_998641_2	713586.KB900536_gene2316	7.46e-30	114.0	COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,1S739@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
k59_1115980_1	935839.JAGJ01000032_gene40	1.06e-38	137.0	COG0716@1|root,COG0716@2|Bacteria,2IQZD@201174|Actinobacteria,4F4Y3@85017|Promicromonosporaceae	201174|Actinobacteria	C	FMN binding	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_1,Flavodoxin_5
k59_705958_1	471853.Bcav_2246	1.9e-145	417.0	COG1938@1|root,COG1938@2|Bacteria,2GK10@201174|Actinobacteria	201174|Actinobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
k59_354601_1	272630.MexAM1_META1p2412	6.53e-08	64.7	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,1JS5X@119045|Methylobacteriaceae	28211|Alphaproteobacteria	QU	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
k59_1175579_2	1517681.HW45_02700	1.04e-42	164.0	COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,1QZAD@1224|Proteobacteria,1RYP3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_999544_1	1304865.JAGF01000001_gene2997	3.1e-54	191.0	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4F0ZE@85016|Cellulomonadaceae	201174|Actinobacteria	C	TIGRFAM 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1410314_1	335283.Neut_1550	7.14e-62	204.0	COG0438@1|root,COG0438@2|Bacteria,1RBQV@1224|Proteobacteria,2W3QE@28216|Betaproteobacteria,371TA@32003|Nitrosomonadales	28216|Betaproteobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_118930_1	933262.AXAM01000013_gene1282	1.9e-77	248.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,2MI0J@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Penicillin-binding Protein dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
k59_647258_1	452637.Oter_1945	2.76e-27	101.0	COG2963@1|root,COG2963@2|Bacteria,46W7R@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_647258_2	671143.DAMO_2019	1.53e-72	232.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_1586336_1	565045.NOR51B_1841	4.4e-58	194.0	COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria	1224|Proteobacteria	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C
k59_1293919_1	96561.Dole_1777	9.15e-48	169.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MPSH@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_883049_1	765914.ThisiDRAFT_1640	3.03e-70	222.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,1WX40@135613|Chromatiales	135613|Chromatiales	EH	PFAM Aminotransferase, class IV	-	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
k59_1469092_1	1713.JOFV01000015_gene1777	5.21e-89	271.0	COG3429@1|root,COG3429@2|Bacteria,2GJ1H@201174|Actinobacteria,4F10N@85016|Cellulomonadaceae	201174|Actinobacteria	G	Glucose-6-phosphate dehydrogenase subunit	opcA	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
k59_1469092_2	446471.Xcel_1555	2.82e-48	167.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,4F3PN@85017|Promicromonosporaceae	201174|Actinobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_1983_2	1125863.JAFN01000001_gene3571	2.13e-27	106.0	COG1595@1|root,COG1595@2|Bacteria,1RHKM@1224|Proteobacteria,43AXT@68525|delta/epsilon subdivisions,2X6BZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1703880_2	195250.CM001776_gene1099	3.36e-65	213.0	COG1171@1|root,COG1171@2|Bacteria,1G22X@1117|Cyanobacteria,1GZ4N@1129|Synechococcus	1117|Cyanobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_764576_1	998088.B565_3042	8.8e-50	169.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1Y3S5@135624|Aeromonadales	135624|Aeromonadales	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
k59_764576_2	1236959.BAMT01000001_gene1623	0.000916	41.6	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2VHDG@28216|Betaproteobacteria,2KM0C@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
k59_1351666_1	1335757.SPICUR_04315	3.59e-36	134.0	COG1985@1|root,COG1985@2|Bacteria,1RDMT@1224|Proteobacteria,1S4SQ@1236|Gammaproteobacteria,1X05Z@135613|Chromatiales	135613|Chromatiales	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_177591_1	471853.Bcav_2416	4.06e-90	283.0	COG0768@1|root,COG0768@2|Bacteria,2GKHH@201174|Actinobacteria	201174|Actinobacteria	M	penicillin-binding protein	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
k59_1293936_1	765914.ThisiDRAFT_2757	2.04e-127	384.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_823325_1	395493.BegalDRAFT_1618	8.89e-92	286.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,4608E@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_1351671_1	391615.ABSJ01000041_gene49	1.84e-60	191.0	COG0346@1|root,COG0346@2|Bacteria,1RHIV@1224|Proteobacteria,1S6V6@1236|Gammaproteobacteria,1JARQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	cadI	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_61162_1	1499686.BN1079_01824	8.11e-65	201.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
k59_61162_2	1123400.KB904774_gene3265	4.61e-18	83.2	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,45ZMT@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_705992_1	208439.AJAP_05655	5.21e-40	150.0	COG1020@1|root,COG1020@2|Bacteria,2GPHZ@201174|Actinobacteria,4E19T@85010|Pseudonocardiales	201174|Actinobacteria	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
k59_354649_1	765911.Thivi_3790	1.65e-78	249.0	28MU5@1|root,2ZB23@2|Bacteria,1R58G@1224|Proteobacteria,1RP0E@1236|Gammaproteobacteria,1WVUZ@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1116866_1	643562.Daes_1653	8.9e-100	319.0	COG1474@1|root,COG1474@2|Bacteria,1R5I2@1224|Proteobacteria,42YAY@68525|delta/epsilon subdivisions,2WU0B@28221|Deltaproteobacteria,2M8RI@213115|Desulfovibrionales	28221|Deltaproteobacteria	LO	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_294996_2	765912.Thimo_3126	1.35e-61	200.0	COG0842@1|root,COG0842@2|Bacteria,1QTBE@1224|Proteobacteria,1RNG9@1236|Gammaproteobacteria,1WXPD@135613|Chromatiales	135613|Chromatiales	U	Transport permease protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
k59_236577_1	1239415.CM001837_gene1570	2.09e-07	58.9	COG0457@1|root,COG0457@2|Bacteria,4PMN3@976|Bacteroidetes,1IJVP@117743|Flavobacteriia	976|Bacteroidetes	M	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_61188_1	985053.VMUT_0627	5.47e-10	64.7	COG0541@1|root,arCOG01228@2157|Archaea,2XPWI@28889|Crenarchaeota	28889|Crenarchaeota	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_61188_2	403833.Pmob_1002	1.11e-16	79.3	COG0781@1|root,COG0781@2|Bacteria,2GDBQ@200918|Thermotogae	200918|Thermotogae	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
k59_1058402_1	1283300.ATXB01000001_gene817	5.95e-52	177.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,1XEM7@135618|Methylococcales	135618|Methylococcales	E	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
k59_1058402_2	1042377.AFPJ01000037_gene2840	1.68e-19	85.9	COG0438@1|root,COG0438@2|Bacteria,1NA28@1224|Proteobacteria,1RQBV@1236|Gammaproteobacteria,4668K@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0438 Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3524,Glyco_trans_1_4,Glycos_transf_1
k59_1351687_1	1163409.UUA_16298	2.26e-76	250.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1X4Z1@135614|Xanthomonadales	135614|Xanthomonadales	G	phosphomannomutase	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_999571_1	312309.VF_2126	1.01e-18	85.1	COG4446@1|root,COG4446@2|Bacteria,1N7IZ@1224|Proteobacteria,1SCZH@1236|Gammaproteobacteria,1XXE2@135623|Vibrionales	135623|Vibrionales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1499
k59_999571_2	349521.HCH_01901	3.11e-09	57.0	COG0235@1|root,COG0235@2|Bacteria,1N2XS@1224|Proteobacteria,1S573@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	PFAM Class II aldolase adducin, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k59_764604_1	1095767.CAHD01000237_gene2871	9.62e-69	231.0	COG4907@1|root,COG4907@2|Bacteria,2GNW7@201174|Actinobacteria	201174|Actinobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
k59_1762548_1	765911.Thivi_3696	1.78e-24	104.0	COG3259@1|root,COG3259@2|Bacteria,1RFVW@1224|Proteobacteria,1T354@1236|Gammaproteobacteria,1X2UT@135613|Chromatiales	135613|Chromatiales	C	Nickel-dependent hydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
k59_999573_2	590998.Celf_3363	2e-31	117.0	COG5343@1|root,COG5343@2|Bacteria,2IM7X@201174|Actinobacteria,4F2HP@85016|Cellulomonadaceae	201174|Actinobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
k59_177630_2	1500893.JQNB01000001_gene2778	1.68e-52	179.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RMKV@1236|Gammaproteobacteria,1X49X@135614|Xanthomonadales	135614|Xanthomonadales	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_1175636_1	56780.SYN_01723	4.31e-116	360.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria,2MQAI@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	TIGRFAM phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_1469141_1	926569.ANT_14280	6.37e-28	111.0	COG0508@1|root,COG0508@2|Bacteria,2G619@200795|Chloroflexi	200795|Chloroflexi	C	Catalytic domain of components of various dehydrogenase complexes	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1469141_2	926569.ANT_14270	5.21e-39	138.0	COG0022@1|root,COG0022@2|Bacteria,2G60F@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Transketolase central region	-	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K11381,ko:K21417	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_529887_1	326427.Cagg_0210	1.08e-17	84.7	COG0805@1|root,COG0805@2|Bacteria,2G6SP@200795|Chloroflexi,375NQ@32061|Chloroflexia	32061|Chloroflexia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_999577_1	1123065.ATWL01000002_gene1391	4.48e-102	301.0	COG1309@1|root,COG1309@2|Bacteria,2GMBW@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	icaR	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_412417_1	1196835.A458_14025	9.79e-17	85.1	COG1805@1|root,COG1805@2|Bacteria,1QTUU@1224|Proteobacteria,1RMGH@1236|Gammaproteobacteria,1Z06H@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrB	GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008144,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019842,GO:0030001,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0048037,GO:0050136,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902444,GO:1902494	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
k59_295030_1	933262.AXAM01000017_gene3145	3.14e-62	213.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2
k59_295030_2	1304885.AUEY01000026_gene3544	2.96e-38	127.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42T3M@68525|delta/epsilon subdivisions,2WPVI@28221|Deltaproteobacteria,2MKVM@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
k59_177645_1	765910.MARPU_11570	2.76e-93	280.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1WWPK@135613|Chromatiales	135613|Chromatiales	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1294020_1	396595.TK90_2128	3.83e-52	171.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,1WY6R@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_1116898_1	864069.MicloDRAFT_00065490	9.47e-57	194.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,1JS4C@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM extracellular solute-binding protein family 5	MA20_18500	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
k59_883148_1	1267005.KB911263_gene1372	4.16e-72	229.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2TSZN@28211|Alphaproteobacteria,3N61J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntAA	GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050662,GO:0051179,GO:0051186,GO:0051234,GO:0051287,GO:0055085,GO:0055086,GO:0055114,GO:0070403,GO:0070404,GO:0071704,GO:0072524,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902600	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_1645429_1	1217718.ALOU01000066_gene1927	2.49e-54	182.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2VIBZ@28216|Betaproteobacteria,1K0ZM@119060|Burkholderiaceae	28216|Betaproteobacteria	GM	Nad-dependent epimerase dehydratase	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
k59_941850_1	335543.Sfum_1971	3.89e-106	317.0	COG1150@1|root,COG1150@2|Bacteria,1QWNB@1224|Proteobacteria,43BTA@68525|delta/epsilon subdivisions,2X741@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
k59_412423_1	313628.LNTAR_00080	9.39e-07	58.5	COG0658@1|root,COG0658@2|Bacteria	2|Bacteria	S	establishment of competence for transformation	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_941854_1	926560.KE387023_gene3658	5.51e-51	169.0	COG0500@1|root,COG2226@2|Bacteria,1WMEJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_706037_1	1528106.JRJE01000009_gene1830	1.78e-55	193.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TTBG@28211|Alphaproteobacteria,2JPA6@204441|Rhodospirillales	204441|Rhodospirillales	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
k59_706037_2	1121921.KB898707_gene1225	1.1e-54	184.0	COG3977@1|root,COG3977@2|Bacteria,1MVRW@1224|Proteobacteria,1RNK1@1236|Gammaproteobacteria,2PN20@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	E	Aminotransferase class I and II	avtA	-	2.6.1.66	ko:K00835	ko00290,ko01100,ko01110,ko01130,map00290,map01100,map01110,map01130	-	R01215	RC00008,RC00036	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_376052_1	1386089.N865_12270	3.89e-12	68.2	COG0699@1|root,COG0699@2|Bacteria,2GJX9@201174|Actinobacteria,4FFE4@85021|Intrasporangiaceae	201174|Actinobacteria	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_376052_2	1123322.KB904656_gene732	1.96e-07	54.7	COG0699@1|root,COG0699@2|Bacteria,2GM68@201174|Actinobacteria	201174|Actinobacteria	K	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
k59_904295_1	1415779.JOMH01000001_gene883	5.37e-42	150.0	COG2962@1|root,COG2962@2|Bacteria,1MX5G@1224|Proteobacteria,1RMAC@1236|Gammaproteobacteria,1X3PF@135614|Xanthomonadales	135614|Xanthomonadales	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1488735_1	479431.Namu_3506	9.83e-26	103.0	COG0306@1|root,COG0306@2|Bacteria,2GJHK@201174|Actinobacteria,4ERKR@85013|Frankiales	201174|Actinobacteria	P	phosphate transporter	pitB	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	iNJ661.Rv2281	PHO4
k59_1488735_2	479431.Namu_3507	1.88e-71	222.0	COG1392@1|root,COG1392@2|Bacteria,2IIE4@201174|Actinobacteria	201174|Actinobacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_1253899_1	2340.JV46_18340	2.16e-76	234.0	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,1S3R2@1236|Gammaproteobacteria,1J6FA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015232,GO:0015886,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019897,GO:0019898,GO:0022857,GO:0031224,GO:0031234,GO:0032991,GO:0042623,GO:0043190,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:1901678,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	iAPECO1_1312.APECO1_4358,iECED1_1282.ECED1_2666,iECS88_1305.ECS88_2348,iECUMN_1333.ECUMN_2536,iLF82_1304.LF82_0273,iNRG857_1313.NRG857_11170,iUMN146_1321.UM146_05800,iUTI89_1310.UTI89_C2479	ABC_tran
k59_1315462_1	926560.KE387023_gene1698	4.58e-82	260.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1WM1W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	KOT	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Response_reg
k59_486042_1	1123401.JHYQ01000007_gene542	9.6e-175	517.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,461JN@72273|Thiotrichales	72273|Thiotrichales	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_427265_1	398578.Daci_3550	3.39e-11	68.6	COG4782@1|root,COG4782@2|Bacteria,1MVAD@1224|Proteobacteria,2VV6E@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Alpha/beta hydrolase of unknown function (DUF900)	-	-	-	-	-	-	-	-	-	-	-	-	DUF900
k59_1843657_1	1174528.JH992898_gene1340	2.07e-43	160.0	COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,1G2D3@1117|Cyanobacteria,1JKE4@1189|Stigonemataceae	1117|Cyanobacteria	CJ	CoA binding domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_963300_1	572477.Alvin_2729	7.27e-99	294.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,1WY2P@135613|Chromatiales	135613|Chromatiales	J	catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
k59_1776985_1	1429851.X548_18965	2.58e-13	74.7	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1X3M3@135614|Xanthomonadales	135614|Xanthomonadales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_544712_1	1122138.AQUZ01000002_gene2105	5.37e-14	70.5	COG0526@1|root,COG0526@2|Bacteria,2GP7J@201174|Actinobacteria,4DRHT@85009|Propionibacteriales	201174|Actinobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
k59_544712_2	471853.Bcav_3253	2.3e-71	224.0	COG0785@1|root,COG0785@2|Bacteria,2GJW3@201174|Actinobacteria	201174|Actinobacteria	O	Cytochrome c biogenesis protein	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
k59_1366637_1	1122138.AQUZ01000060_gene3877	1.59e-33	124.0	COG3428@1|root,COG3428@2|Bacteria,2GK6Y@201174|Actinobacteria,4DRJ7@85009|Propionibacteriales	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
k59_1366637_2	591159.ACEZ01000099_gene5697	1.09e-09	60.8	COG0477@1|root,COG1846@1|root,COG0477@2|Bacteria,COG1846@2|Bacteria,2GJ09@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_904321_1	519989.ECTPHS_02801	7.87e-74	236.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWMG@135613|Chromatiales	135613|Chromatiales	L	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_427276_1	382464.ABSI01000010_gene3668	1.83e-90	281.0	COG0843@1|root,COG0843@2|Bacteria,46S4Q@74201|Verrucomicrobia,2ITKY@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	-	-	-	-	-	-	-	-	-	-	COX1
k59_662742_2	290399.Arth_1589	6.48e-154	439.0	COG0024@1|root,COG0024@2|Bacteria,2GKIZ@201174|Actinobacteria,1W8P5@1268|Micrococcaceae	201174|Actinobacteria	J	Methionine aminopeptidase	map	GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564,GO:1901605	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_1079821_1	713586.KB900536_gene468	1.82e-73	233.0	COG1253@1|root,COG1253@2|Bacteria,1N0IQ@1224|Proteobacteria,1RY1D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function DUF21	-	-	-	-	-	-	-	-	-	-	-	-	DUF21
k59_260150_1	105559.Nwat_1590	2.42e-71	226.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1WWRK@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
k59_309967_1	768671.ThimaDRAFT_3380	9.08e-52	172.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,1WXSE@135613|Chromatiales	135613|Chromatiales	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	-	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
k59_544724_1	1502851.FG93_03405	5.53e-33	123.0	COG0715@1|root,COG0715@2|Bacteria,1R4AB@1224|Proteobacteria,2U2A0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport systems periplasmic	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
k59_544724_2	1502851.FG93_03406	4.87e-21	92.0	COG0600@1|root,COG0600@2|Bacteria,1R546@1224|Proteobacteria,2TTRM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_1315500_1	1304865.JAGF01000001_gene1621	1.23e-99	310.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4F0UZ@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
k59_1426230_1	1123392.AQWL01000002_gene1898	2.92e-98	294.0	COG1893@1|root,COG1893@2|Bacteria,1R60C@1224|Proteobacteria,2WBPG@28216|Betaproteobacteria,1KSB5@119069|Hydrogenophilales	119069|Hydrogenophilales	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1426230_2	1415780.JPOG01000001_gene2551	1.13e-13	69.3	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,1RQ3P@1236|Gammaproteobacteria,1X5PT@135614|Xanthomonadales	135614|Xanthomonadales	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
k59_721390_1	765911.Thivi_3166	5.79e-36	131.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria,1WY8Z@135613|Chromatiales	135613|Chromatiales	S	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
k59_1718512_1	379731.PST_2949	1.21e-95	294.0	COG2509@1|root,COG2509@2|Bacteria,1MV6P@1224|Proteobacteria,1RPTW@1236|Gammaproteobacteria,1YZSV@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	FAD-dependent	IV02_08645	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	Amino_oxidase
k59_1661105_1	1121904.ARBP01000002_gene7034	4.44e-13	75.9	COG0642@1|root,COG2203@1|root,COG4251@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,4NDXU@976|Bacteroidetes,47JK3@768503|Cytophagia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg
k59_1079838_1	98439.AJLL01000036_gene2733	1.46e-56	198.0	COG0458@1|root,COG0458@2|Bacteria,1G00J@1117|Cyanobacteria,1JJ92@1189|Stigonemataceae	1117|Cyanobacteria	EF	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_1718513_1	1165096.ARWF01000001_gene765	3.76e-31	114.0	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,2VT0P@28216|Betaproteobacteria,2KMWX@206350|Nitrosomonadales	206350|Nitrosomonadales	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
k59_1191252_1	1448857.JFAP01000001_gene1073	3.2e-10	68.9	COG3437@1|root,COG4252@1|root,COG3437@2|Bacteria,COG4252@2|Bacteria,1MUB8@1224|Proteobacteria,42MFV@68525|delta/epsilon subdivisions,2YM95@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	KT	CHASE2	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,HD
k59_544741_1	999547.KI421500_gene3551	4.09e-75	234.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria,2823D@191028|Leisingera	28211|Alphaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_838533_1	296591.Bpro_4271	6.85e-51	177.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,2VMJ9@28216|Betaproteobacteria,4AJBV@80864|Comamonadaceae	28216|Betaproteobacteria	O	Uncharacterized protein family (UPF0051)	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_838533_2	631362.Thi970DRAFT_03989	9.38e-08	52.4	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,1S619@1236|Gammaproteobacteria,1X278@135613|Chromatiales	135613|Chromatiales	S	FeS assembly SUF system protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
k59_309990_1	582899.Hden_2582	1.68e-122	362.0	COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria,3N6F3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	glutamate--cysteine ligase	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GCS2
k59_662775_1	933262.AXAM01000046_gene129	3.08e-67	215.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,2MHVQ@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_82559_1	94122.Shewana3_1424	6.26e-47	169.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,2QADF@267890|Shewanellaceae	1236|Gammaproteobacteria	I	PFAM phospholipase D Transphosphatidylase	clsC	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:0090483,GO:1901576	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_1661122_1	314231.FP2506_16194	7.69e-60	211.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,HemolysinCabind
k59_544751_1	65093.PCC7418_1356	2.74e-20	84.3	COG3411@1|root,COG3411@2|Bacteria,1G5V6@1117|Cyanobacteria	1117|Cyanobacteria	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_544751_2	2340.JV46_04630	6.76e-41	142.0	COG0758@1|root,COG0758@2|Bacteria,1MZGB@1224|Proteobacteria,1S95S@1236|Gammaproteobacteria,1JB42@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	LU	Putative molybdenum carrier	-	-	-	-	-	-	-	-	-	-	-	-	MoCo_carrier
k59_1542621_1	1463936.JOJI01000024_gene1269	5.21e-70	228.0	COG0475@1|root,COG0475@2|Bacteria,2GJ69@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sodium hydrogen exchanger	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
k59_1542621_2	710696.Intca_0410	3.36e-18	79.0	2DRYE@1|root,33DPC@2|Bacteria,2IS24@201174|Actinobacteria,4FHPE@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_486091_1	1206731.BAGB01000064_gene7363	4.13e-66	209.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4FY7P@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_260201_1	497321.C664_18844	3.19e-61	209.0	COG4774@1|root,COG4774@2|Bacteria,1MV0X@1224|Proteobacteria,2VIQR@28216|Betaproteobacteria,2KVX3@206389|Rhodocyclales	206389|Rhodocyclales	P	receptor	-	-	-	ko:K16090	-	-	-	-	ko00000,ko02000	1.B.14.1.11	-	-	Plug,TonB_dep_Rec
k59_603238_1	977880.RALTA_B1562	2.13e-65	206.0	COG5553@1|root,COG5553@2|Bacteria,1R5RR@1224|Proteobacteria,2VQ9W@28216|Betaproteobacteria,1K60U@119060|Burkholderiaceae	28216|Betaproteobacteria	C	cysteine dioxygenase type I	-	-	-	-	-	-	-	-	-	-	-	-	CDO_I
k59_260211_1	631362.Thi970DRAFT_03332	9.07e-109	336.0	COG0480@1|root,COG0480@2|Bacteria,1PMU3@1224|Proteobacteria,1S00P@1236|Gammaproteobacteria,1WXBY@135613|Chromatiales	135613|Chromatiales	J	small GTP-binding protein	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1079876_1	1125973.JNLC01000012_gene717	5.62e-128	377.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2TR47@28211|Alphaproteobacteria,3JTX8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Glucose / Sorbosone dehydrogenase	yliI	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0055114,GO:0070968,GO:0097159,GO:1901363	1.1.5.2	ko:K00117,ko:K21430	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	GSDH
k59_904396_1	1283300.ATXB01000001_gene319	4.92e-80	255.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1XEDM@135618|Methylococcales	135618|Methylococcales	C	Aconitase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aconitase,Aconitase_C
k59_963377_1	1304865.JAGF01000001_gene2953	8.21e-140	412.0	COG0328@1|root,COG0406@1|root,COG0328@2|Bacteria,COG0406@2|Bacteria,2GJ9R@201174|Actinobacteria,4F0GQ@85016|Cellulomonadaceae	201174|Actinobacteria	G	Phosphoglycerate mutase family	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	3.1.26.4,3.1.3.73	ko:K02226,ko:K22316	ko00860,ko01100,ko03030,map00860,map01100,map03030	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	His_Phos_1,RVT_3
k59_1191275_1	367299.JOEE01000004_gene941	2.47e-98	291.0	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,4FF9X@85021|Intrasporangiaceae	201174|Actinobacteria	G	Inositol monophosphatase family	hisN	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15,3.1.3.25	ko:K01092,ko:K05602	ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00131	R01185,R01186,R01187,R03013	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_193173_1	1395571.TMS3_0111920	1.17e-101	321.0	COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,1RN6T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	The M ring may be actively involved in energy transduction	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
k59_376162_1	349102.Rsph17025_1035	2.89e-21	101.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,1FAYB@1060|Rhodobacter	28211|Alphaproteobacteria	S	Putative peptidoglycan binding domain	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_427332_1	62977.ACIAD0409	1.14e-18	86.3	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,3NJI2@468|Moraxellaceae	1236|Gammaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_427332_2	754477.Q7C_1967	1.14e-14	74.3	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,4604M@72273|Thiotrichales	72273|Thiotrichales	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_662793_2	2340.JV46_15450	5.11e-12	65.9	COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S dicluster domain	dsrK	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8
k59_1315565_1	590998.Celf_1664	7.24e-133	390.0	COG4992@1|root,COG4992@2|Bacteria,2GKE9@201174|Actinobacteria,4F0TN@85016|Cellulomonadaceae	201174|Actinobacteria	E	TIGRFAM acetylornithine and succinylornithine aminotransferase	argD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0008150,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_82584_1	926550.CLDAP_15280	5.6e-34	135.0	COG0793@1|root,COG3468@1|root,COG0793@2|Bacteria,COG3468@2|Bacteria,2G7PQ@200795|Chloroflexi	200795|Chloroflexi	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
k59_1777049_1	287.DR97_1075	5.1e-55	176.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,1S5YQ@1236|Gammaproteobacteria,1YFTU@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	J	RF-1 domain	yaeJ	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
k59_1129778_1	686340.Metal_1865	2.76e-52	173.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1XEJ1@135618|Methylococcales	135618|Methylococcales	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_544766_1	754476.Q7A_1669	1.57e-45	150.0	COG0346@1|root,COG0346@2|Bacteria,1RIR2@1224|Proteobacteria,1S7P4@1236|Gammaproteobacteria,462R7@72273|Thiotrichales	72273|Thiotrichales	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_544766_2	582744.Msip34_0434	1.73e-73	223.0	COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,2VR62@28216|Betaproteobacteria,2KMKZ@206350|Nitrosomonadales	206350|Nitrosomonadales	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
k59_1129779_1	1123256.KB907940_gene194	1.02e-11	65.9	COG3391@1|root,COG3391@2|Bacteria,1P03Z@1224|Proteobacteria	1224|Proteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1129779_2	1250232.JQNJ01000001_gene1542	4.49e-06	49.7	COG0810@1|root,COG0810@2|Bacteria,4NWD2@976|Bacteroidetes,1I57H@117743|Flavobacteriia	976|Bacteroidetes	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_311009_1	1123487.KB892846_gene388	1.26e-11	68.9	COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2VJE8@28216|Betaproteobacteria,2KXU6@206389|Rhodocyclales	206389|Rhodocyclales	S	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1192211_1	472759.Nhal_3820	3.81e-52	186.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
k59_1543511_1	1151126.AQYI01000006_gene2791	4.21e-12	66.6	COG0524@1|root,COG0524@2|Bacteria,2GYHF@201174|Actinobacteria,4FP0W@85023|Microbacteriaceae	201174|Actinobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_1543511_2	1284679.HMPREF1626_04225	8.85e-19	85.1	COG4733@1|root,COG4733@2|Bacteria,2I3TX@201174|Actinobacteria	201174|Actinobacteria	G	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
k59_1316839_1	590998.Celf_0091	6.36e-14	67.0	2E63U@1|root,330SV@2|Bacteria,2GSXM@201174|Actinobacteria,4F2VH@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_663724_1	304371.MCP_1287	3.35e-71	233.0	arCOG02350@1|root,arCOG06516@1|root,arCOG02350@2157|Archaea,arCOG06516@2157|Archaea,2Y7T4@28890|Euryarchaeota,2NATC@224756|Methanomicrobia	2157|Archaea	T	Contains one ATP-binding region, ATPase-like domain (IPR003594)	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_1081155_1	935839.JAGJ01000003_gene1579	1.32e-78	237.0	COG1755@1|root,COG1755@2|Bacteria,2IG52@201174|Actinobacteria,4F4FE@85017|Promicromonosporaceae	201174|Actinobacteria	S	Phospholipid methyltransferase	srsB	-	-	ko:K16168	-	-	-	-	ko00000,ko01008	-	-	-	ICMT
k59_1081155_2	1380354.JIAN01000007_gene365	1.87e-48	168.0	COG3424@1|root,COG3424@2|Bacteria,2GV0U@201174|Actinobacteria,4F0T0@85016|Cellulomonadaceae	201174|Actinobacteria	Q	FAE1/Type III polyketide synthase-like protein	-	-	-	ko:K16167	-	-	-	-	ko00000,ko01008	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
k59_261806_1	349521.HCH_04816	3.62e-76	236.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1XIQJ@135619|Oceanospirillales	135619|Oceanospirillales	BQ	deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_487054_1	471853.Bcav_0610	3.58e-56	183.0	COG1073@1|root,COG1073@2|Bacteria,2I4CP@201174|Actinobacteria	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_722241_1	1121405.dsmv_2727	1.02e-96	305.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MHRD@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_27904_1	1049564.TevJSym_bk00210	3.37e-100	302.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1J4SA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	iYL1228.KPN_02462	AdoHcyase,AdoHcyase_NAD
k59_487058_1	644548.SCNU_09664	2.83e-77	241.0	COG2896@1|root,COG2896@2|Bacteria,2GN0V@201174|Actinobacteria,4GCMG@85026|Gordoniaceae	201174|Actinobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
k59_1601770_1	1163617.SCD_n02730	1.25e-89	268.0	COG3132@1|root,COG3132@2|Bacteria,1RA13@1224|Proteobacteria,2VQGS@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the UPF0502 family	yceH	-	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480
k59_1316855_1	1167006.UWK_00034	3.52e-45	158.0	COG3221@1|root,COG3221@2|Bacteria,1QVNP@1224|Proteobacteria,42S28@68525|delta/epsilon subdivisions,2WP33@28221|Deltaproteobacteria,2MN7E@213118|Desulfobacterales	28221|Deltaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Phosphonate-bd
k59_1719523_1	1167006.UWK_00605	5.87e-107	326.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,42MTV@68525|delta/epsilon subdivisions,2WKVP@28221|Deltaproteobacteria,2MMZI@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF853)	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
k59_388686_1	1031711.RSPO_c01172	4.07e-21	95.5	COG0834@1|root,COG0834@2|Bacteria,1MVT6@1224|Proteobacteria,2VK4N@28216|Betaproteobacteria,1K032@119060|Burkholderiaceae	28216|Betaproteobacteria	ET	Amino acid ABC transporter substrate-binding protein	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_1089698_2	1349820.M707_21430	7.81e-170	486.0	COG1672@1|root,COG1672@2|Bacteria,2GWBV@201174|Actinobacteria,1W83I@1268|Micrococcaceae	201174|Actinobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
k59_1669206_1	1238182.C882_1140	2.32e-46	169.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,2TUKS@28211|Alphaproteobacteria,2JPAC@204441|Rhodospirillales	204441|Rhodospirillales	KL	HELICc2	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Helicase_C_2
k59_1784512_1	395493.BegalDRAFT_3088	3.81e-77	243.0	COG3156@1|root,COG3156@2|Bacteria,1RAQM@1224|Proteobacteria,1S2N8@1236|Gammaproteobacteria,460PF@72273|Thiotrichales	72273|Thiotrichales	U	Type II secretion system (T2SS), protein K	-	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
k59_494036_1	591158.SSMG_03694	1.77e-67	230.0	COG0110@1|root,COG1020@1|root,COG0110@2|Bacteria,COG1020@2|Bacteria,2I8TI@201174|Actinobacteria	201174|Actinobacteria	Q	non-ribosomal peptide synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Hexapep,Hexapep_2,PP-binding
k59_1328283_1	323850.Shew_0563	7.79e-08	58.2	COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,2QA31@267890|Shewanellaceae	1236|Gammaproteobacteria	M	cell wall hydrolase autolysin	amiB	GO:0000003,GO:0000910,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0008745,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019954,GO:0022402,GO:0022414,GO:0030288,GO:0030313,GO:0031975,GO:0032505,GO:0042597,GO:0043093,GO:0044464,GO:0051301,GO:0061783	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	iG2583_1286.G2583_4996	AMIN,Amidase_3,LysM
k59_388705_1	219305.MCAG_03096	3.35e-19	93.2	COG0501@1|root,COG0501@2|Bacteria,2GZ0N@201174|Actinobacteria,4DJKN@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_1726704_1	1123261.AXDW01000009_gene94	4.44e-59	207.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1X4MI@135614|Xanthomonadales	135614|Xanthomonadales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_1856589_1	765914.ThisiDRAFT_1039	5.48e-95	297.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1WWD1@135613|Chromatiales	135613|Chromatiales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_729017_1	1121013.P873_04720	3.14e-29	118.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,1X452@135614|Xanthomonadales	135614|Xanthomonadales	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1784521_1	1267005.KB911256_gene1803	1.64e-98	300.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2TRMX@28211|Alphaproteobacteria,3N80X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Peptidase M16 inactive domain	MA20_05660	-	-	ko:K07263,ko:K07623	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1434375_1	717785.HYPMC_3257	7.08e-54	181.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,3N8ZI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1434375_2	1236541.BALL01000001_gene39	2.17e-30	113.0	COG0789@1|root,COG0789@2|Bacteria,1RGX6@1224|Proteobacteria,1S8ZG@1236|Gammaproteobacteria,2QC71@267890|Shewanellaceae	1236|Gammaproteobacteria	K	PFAM regulatory protein, MerR	cueR	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001130,GO:0001131,GO:0001199,GO:0001204,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071241,GO:0071248,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K19591	-	M00769	-	-	ko00000,ko00002,ko01504,ko03000	-	-	-	MerR,MerR-DNA-bind,MerR_1
k59_273382_1	5786.XP_003290617.1	6.36e-16	79.3	COG0642@1|root,KOG0519@2759|Eukaryota,3XEKE@554915|Amoebozoa	554915|Amoebozoa	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,HATPase_c,HisKA,Pkinase,Response_reg
k59_273382_2	1185653.A1A1_09231	7.56e-17	82.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HBZ0@91061|Bacilli,26D74@186818|Planococcaceae	91061|Bacilli	T	Histidine kinase	resE	-	2.7.13.3	ko:K07651	ko02020,map02020	M00458	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
k59_1785187_2	1049564.TevJSym_ac00750	2.25e-158	454.0	COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,1RM9B@1236|Gammaproteobacteria,1J56V@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	N	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliG	GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
k59_671289_1	1121405.dsmv_0657	3.89e-70	228.0	COG3894@1|root,COG3894@2|Bacteria,1MX9D@1224|Proteobacteria,42PW1@68525|delta/epsilon subdivisions,2WJZD@28221|Deltaproteobacteria,2MHZX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445
k59_390141_1	1121918.ARWE01000001_gene746	2.22e-110	345.0	COG0457@1|root,COG0457@2|Bacteria,1R1JQ@1224|Proteobacteria,4377S@68525|delta/epsilon subdivisions,2WTFW@28221|Deltaproteobacteria,43U9G@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
k59_918481_1	203122.Sde_3310	3.78e-52	176.0	COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria,466B8@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	DNA polymerase III, delta subunit	holA	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delt_C,DNA_pol3_delta
k59_553468_1	479431.Namu_0309	5.24e-125	381.0	COG1080@1|root,COG1925@1|root,COG2190@1|root,COG1080@2|Bacteria,COG1925@2|Bacteria,COG2190@2|Bacteria,2GIZZ@201174|Actinobacteria,4ERGZ@85013|Frankiales	201174|Actinobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.1.202,2.7.3.9	ko:K02768,ko:K08483,ko:K11183	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PPDK_N,PTS-HPr,PTS_EIIA_1
k59_1200099_1	626887.J057_20385	3.4e-142	410.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,464DG@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475	TGT
k59_1550967_1	472759.Nhal_0506	4.1e-147	425.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,1WWG7@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_1019465_1	1384056.N787_03670	1.41e-39	145.0	COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,1RN5P@1236|Gammaproteobacteria,1X3R9@135614|Xanthomonadales	135614|Xanthomonadales	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	AAA_23,SMC_N
k59_96732_1	1160137.KB907307_gene3924	1.03e-24	99.0	COG1309@1|root,COG1309@2|Bacteria,2GQRD@201174|Actinobacteria,4FXP0@85025|Nocardiaceae	201174|Actinobacteria	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
k59_1329812_1	670307.HYPDE_28608	1.14e-80	258.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,3N84S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	acyl-CoA dehydrogenase	mmgC	-	1.3.8.1,1.3.8.7	ko:K00248,ko:K00249,ko:K20035	ko00071,ko00280,ko00410,ko00640,ko00650,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map00920,map01100,map01110,map01120,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754,R11130	RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246,RC03363	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_40149_1	1449347.JQLN01000005_gene3751	1.24e-15	81.6	COG0739@1|root,COG0739@2|Bacteria,2GKXN@201174|Actinobacteria,2M292@2063|Kitasatospora	201174|Actinobacteria	M	heme binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_729843_1	47716.JOFH01000032_gene7197	8.04e-47	164.0	COG1013@1|root,COG1013@2|Bacteria,2GMI5@201174|Actinobacteria	201174|Actinobacteria	C	Ferredoxin oxidoreductase	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_1090503_1	1517681.HW45_26610	1.66e-95	295.0	COG2985@1|root,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,1RQ47@1236|Gammaproteobacteria,1XWS1@135623|Vibrionales	135623|Vibrionales	U	Predicted Permease Membrane Region	-	-	-	-	-	-	-	-	-	-	-	-	Asp-Al_Ex
k59_96743_1	358681.BBR47_46770	1.15e-21	94.0	COG0332@1|root,COG0332@2|Bacteria,1UYNP@1239|Firmicutes,4HECC@91061|Bacilli,26SG1@186822|Paenibacillaceae	91061|Bacilli	I	differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_96743_2	56110.Oscil6304_5376	5.71e-29	112.0	COG0491@1|root,COG0491@2|Bacteria,1G9C5@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Metallo-beta-lactamase superfamily	-	-	3.1.1.81	ko:K13075	ko02024,map02024	-	R08970	RC00713	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
k59_1670076_1	910314.HMPREF9220_1142	1.9e-82	262.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,4H1XW@909932|Negativicutes	909932|Negativicutes	H	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_96744_1	765912.Thimo_0189	7.9e-134	392.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1WW3A@135613|Chromatiales	135613|Chromatiales	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
k59_1329836_2	1286632.P278_03710	3.37e-29	107.0	COG2044@1|root,COG2044@2|Bacteria,4P2I4@976|Bacteroidetes,1I8SH@117743|Flavobacteriia	976|Bacteroidetes	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
k59_977615_1	1178482.BJB45_00290	1.2e-38	137.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,1XJHS@135619|Oceanospirillales	135619|Oceanospirillales	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_612190_1	580332.Slit_1176	5.06e-31	125.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2VI2R@28216|Betaproteobacteria	28216|Betaproteobacteria	S	alpha-2-macroglobulin domain protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,MG1,Thiol-ester_cl
k59_201646_1	744980.TRICHSKD4_2960	6.63e-109	325.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2826 Transposase and inactivated derivatives, IS30 family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_1375071_1	768671.ThimaDRAFT_3386	5.89e-68	222.0	COG0265@1|root,COG3016@1|root,COG0265@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,1RPWZ@1236|Gammaproteobacteria,1WX9T@135613|Chromatiales	135613|Chromatiales	O	smart pdz dhr glgf	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg,PDZ_2
k59_1375071_2	396588.Tgr7_2778	3.15e-129	407.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales	135613|Chromatiales	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_1727553_1	1121405.dsmv_3060	6.16e-24	91.7	2CGS2@1|root,32S4H@2|Bacteria,1N2GM@1224|Proteobacteria,42TM5@68525|delta/epsilon subdivisions,2WQTK@28221|Deltaproteobacteria,2MKF0@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1727553_2	1045855.DSC_01505	1.74e-15	79.3	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1X31Q@135614|Xanthomonadales	135614|Xanthomonadales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_1264576_1	998674.ATTE01000001_gene394	1.09e-07	52.8	COG0477@1|root,COG2814@2|Bacteria,1QUY6@1224|Proteobacteria,1S2RA@1236|Gammaproteobacteria,463KE@72273|Thiotrichales	72273|Thiotrichales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1264576_2	1262449.CP6013_1359	2.36e-48	169.0	COG1906@1|root,COG1906@2|Bacteria,1UHZ1@1239|Firmicutes,248VI@186801|Clostridia,36UMH@31979|Clostridiaceae	186801|Clostridia	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1090513_1	156889.Mmc1_0519	1.32e-133	405.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TS80@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1090514_1	180281.CPCC7001_1333	4.34e-26	111.0	COG0763@1|root,COG0763@2|Bacteria,1G0V6@1117|Cyanobacteria,22RWS@167375|Cyanobium	1117|Cyanobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
k59_1499026_1	1255043.TVNIR_2416	6.32e-48	177.0	COG0784@1|root,COG2198@1|root,COG2202@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg
k59_553506_1	1038862.KB893806_gene2742	6.44e-11	65.5	COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TUA9@28211|Alphaproteobacteria,3JRPT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase,PBP
k59_553506_2	1177928.TH2_00695	1.57e-05	50.8	COG1846@1|root,COG1846@2|Bacteria,1N78T@1224|Proteobacteria,2UFV6@28211|Alphaproteobacteria,2JTWQ@204441|Rhodospirillales	204441|Rhodospirillales	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	ko:K06075	-	-	-	-	ko00000,ko03000	-	-	-	HTH_27,MarR,MarR_2
k59_1435221_1	717785.HYPMC_4757	2.87e-84	257.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,2TSR7@28211|Alphaproteobacteria,3N9CV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
k59_1727570_2	768066.HELO_4443	3.83e-07	50.8	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,1S25H@1236|Gammaproteobacteria,1XK0R@135619|Oceanospirillales	135619|Oceanospirillales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
k59_847347_1	1489678.RDMS_10290	4.71e-53	182.0	COG2070@1|root,COG2070@2|Bacteria,1WMCT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Nitronate monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
k59_1375094_1	472759.Nhal_2360	1.34e-51	174.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1WX0P@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_918569_1	979556.MTES_0772	5.58e-58	182.0	COG3304@1|root,COG3304@2|Bacteria,2IKS5@201174|Actinobacteria,4FP5V@85023|Microbacteriaceae	201174|Actinobacteria	S	Inner membrane component domain	yccF	-	-	-	-	-	-	-	-	-	-	-	YccF
k59_1609157_2	713586.KB900536_gene61	7.67e-121	352.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,1WXGF@135613|Chromatiales	135613|Chromatiales	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_40200_1	536227.CcarbDRAFT_4346	1.77e-07	58.9	COG4974@1|root,COG4974@2|Bacteria,1TY7M@1239|Firmicutes,24BN9@186801|Clostridia,36G10@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
k59_1329893_1	880072.Desac_0737	2.61e-44	146.0	COG1146@1|root,COG1146@2|Bacteria,1RC9N@1224|Proteobacteria	1224|Proteobacteria	C	reductase, beta subunit	aprB	-	1.8.99.2	ko:K00395	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	APS-reductase_C,Fer4,Fer4_9
k59_1329893_2	289376.THEYE_A1832	3.45e-33	127.0	COG1053@1|root,COG1053@2|Bacteria,3J0YZ@40117|Nitrospirae	40117|Nitrospirae	C	FAD binding domain	-	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
k59_1137998_1	589865.DaAHT2_1278	1.51e-46	157.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,42QT1@68525|delta/epsilon subdivisions,2WNK6@28221|Deltaproteobacteria,2MJM4@213118|Desulfobacterales	28221|Deltaproteobacteria	H	TIGRFAM riboflavin synthase, alpha subunit	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
k59_143130_1	408672.NBCG_04420	1.04e-107	318.0	COG2515@1|root,COG2515@2|Bacteria,2GIV5@201174|Actinobacteria,4DPG5@85009|Propionibacteriales	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	acdS	-	3.5.99.7,4.4.1.15	ko:K01505,ko:K05396	ko00270,map00270	-	R00997,R01874	RC00382,RC00419	ko00000,ko00001,ko01000	-	-	-	PALP
k59_1264608_1	1121930.AQXG01000011_gene1720	1.59e-92	288.0	COG2132@1|root,COG2132@2|Bacteria,4NE3N@976|Bacteroidetes	976|Bacteroidetes	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_671364_1	1392540.P256_00789	4.06e-27	118.0	COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,3NM5B@468|Moraxellaceae	1236|Gammaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_319180_2	472759.Nhal_2780	3.5e-30	116.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,1RWHU@1236|Gammaproteobacteria,1WYF3@135613|Chromatiales	135613|Chromatiales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161,ko:K00162,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_1200156_1	1049564.TevJSym_bo00190	1.78e-142	432.0	COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,1RQ9A@1236|Gammaproteobacteria,1J616@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	ko:K02569	-	-	-	-	ko00000	-	-	-	Cytochrom_NNT,EB_dh
k59_1858170_1	913325.N799_04540	4.77e-41	155.0	COG4191@1|root,COG4191@2|Bacteria,1QU2S@1224|Proteobacteria,1T1NI@1236|Gammaproteobacteria,1XD4X@135614|Xanthomonadales	135614|Xanthomonadales	T	two-component system sensor protein	phoQ	-	2.7.13.3	ko:K07637	ko01503,ko02020,map01503,map02020	M00444,M00709,M00721,M00723,M00724,M00744	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HATPase_c
k59_1858170_2	1123393.KB891327_gene427	2.26e-36	127.0	2CIC4@1|root,3328Z@2|Bacteria,1N7FS@1224|Proteobacteria,2VX81@28216|Betaproteobacteria,1KTBC@119069|Hydrogenophilales	119069|Hydrogenophilales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1329921_1	1042375.AFPL01000043_gene1403	8.19e-31	115.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,464QZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666	ATP-synt_A
k59_1329921_3	1269813.ATUL01000004_gene2259	2.32e-11	62.8	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1WWNZ@135613|Chromatiales	135613|Chromatiales	K	Belongs to the ParB family	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_612237_1	1049564.TevJSym_aa00790	1.72e-90	277.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1J4PX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iEC55989_1330.EC55989_0819,iECO111_1330.ECO111_0837,iECO26_1355.ECO26_0902,iSDY_1059.SDY_0830	Aminotran_1_2
k59_1670142_2	1167006.UWK_03191	2.19e-16	73.2	2EIMJ@1|root,33CCU@2|Bacteria,1NMXZ@1224|Proteobacteria,433IY@68525|delta/epsilon subdivisions,2WY9B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1375126_1	1232683.ADIMK_1376	7.81e-95	293.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria,4658Y@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Acetyl-CoA dehydrogenase C-terminal like	-	-	-	ko:K20035	ko00920,map00920	-	R11130	RC03363	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_96872_1	1056512.D515_03559	1.3e-75	230.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,1S45S@1236|Gammaproteobacteria,1XUPT@135623|Vibrionales	135623|Vibrionales	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	bfr	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
k59_1609198_1	864702.OsccyDRAFT_1105	1.61e-19	90.1	COG3408@1|root,COG3408@2|Bacteria,1G2UV@1117|Cyanobacteria,1H7G6@1150|Oscillatoriales	1117|Cyanobacteria	G	PFAM Plant neutral invertase	invA	-	3.2.1.26	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R00802,R02410,R03635,R03921,R06088	RC00028,RC00077	ko00000,ko00001,ko01000	-	GH32	-	Glyco_hydro_100
k59_273497_1	1045855.DSC_04670	0.000304	43.5	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1X2Y5@135614|Xanthomonadales	135614|Xanthomonadales	LU	DNA processing protein DprA	smf	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_273497_2	1049564.TevJSym_ag01080	9.34e-46	154.0	COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1J6PQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF494)	smg	-	-	ko:K03747	-	-	-	-	ko00000	-	-	-	DUF494
k59_40250_2	765911.Thivi_3114	1.27e-183	520.0	COG1148@1|root,COG1148@2|Bacteria,1Q0ZF@1224|Proteobacteria,1RYIC@1236|Gammaproteobacteria,1WY81@135613|Chromatiales	135613|Chromatiales	C	FAD dependent oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388,ko:K16885	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored
k59_401912_1	706587.Desti_5051	4.06e-58	189.0	COG0667@1|root,COG0667@2|Bacteria,1QJYC@1224|Proteobacteria,42QD6@68525|delta/epsilon subdivisions,2WJ6W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_401912_2	767817.Desgi_4311	4.58e-07	51.6	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,260I5@186807|Peptococcaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_150331_1	1200792.AKYF01000026_gene139	9.38e-17	79.3	COG0436@1|root,COG0436@2|Bacteria,1TQPD@1239|Firmicutes,4HE7P@91061|Bacilli,272I9@186822|Paenibacillaceae	91061|Bacilli	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_150331_2	1423321.AS29_06835	3.8e-08	59.3	COG0624@1|root,COG0624@2|Bacteria,1TQS9@1239|Firmicutes,4HDHW@91061|Bacilli,1ZBDC@1386|Bacillus	91061|Bacilli	E	Acetylornithine deacetylase	yodQ	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1207001_1	243233.MCA0106	1.05e-65	209.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,1XE1X@135618|Methylococcales	135618|Methylococcales	EH	PFAM Aminotransferase, class IV	-	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
k59_1734393_1	1123393.KB891316_gene1736	3.67e-148	451.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,1KSFJ@119069|Hydrogenophilales	119069|Hydrogenophilales	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_560370_1	199310.c2708	3.31e-42	148.0	COG0231@1|root,COG0231@2|Bacteria,1NWY9@1224|Proteobacteria,1RQ0N@1236|Gammaproteobacteria,3XNJG@561|Escherichia	1236|Gammaproteobacteria	J	translation elongation factor activity	yeiP	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
k59_560370_2	1104325.M7W_2651	5.4e-06	52.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,4HA9K@91061|Bacilli,4AZZ2@81852|Enterococcaceae	91061|Bacilli	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	-	-	-	-	-	-	-	-	-	Dus
k59_501776_1	1033802.SSPSH_000272	4.52e-71	228.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_678660_1	1504319.GM45_0380	3.28e-69	231.0	COG2609@1|root,COG2609@2|Bacteria,2GJRE@201174|Actinobacteria,3UW8H@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0004739,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016624,GO:0016903,GO:0030312,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046872,GO:0055114,GO:0071944,GO:1902494,GO:1990204	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_1507152_1	479432.Sros_9301	2.56e-11	65.5	COG3346@1|root,COG3346@2|Bacteria,2GR90@201174|Actinobacteria,4EHHN@85012|Streptosporangiales	201174|Actinobacteria	S	SURF1 family	-	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	SURF1
k59_1507152_2	468556.AQYG01000047_gene1563	4.12e-15	74.3	COG0215@1|root,COG0215@2|Bacteria,2GJZR@201174|Actinobacteria,4GAGS@85026|Gordoniaceae	201174|Actinobacteria	J	Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins	mshC	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iNJ661.Rv2130c	tRNA-synt_1e
k59_326057_1	1286631.X805_34140	0.000476	42.7	COG2358@1|root,COG2358@2|Bacteria,1PNJV@1224|Proteobacteria,2VI8H@28216|Betaproteobacteria,1KKCI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
k59_326057_2	999141.GME_01574	7.23e-61	202.0	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,1T05M@1236|Gammaproteobacteria,1XNUY@135619|Oceanospirillales	135619|Oceanospirillales	P	CorA-like Mg2+ transporter protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_1143933_1	1385935.N836_33495	5.29e-08	60.5	COG1566@1|root,COG1566@2|Bacteria,1G2SH@1117|Cyanobacteria	1117|Cyanobacteria	V	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
k59_619016_3	1385517.N800_09070	9.51e-61	192.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,1S60Z@1236|Gammaproteobacteria,1X61I@135614|Xanthomonadales	135614|Xanthomonadales	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,MafB19-deam,dCMP_cyt_deam_1
k59_619016_4	1283300.ATXB01000001_gene66	1.36e-61	205.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1XF9A@135618|Methylococcales	135618|Methylococcales	M	Transglycosylase SLT domain	-	-	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
k59_501796_1	1265505.ATUG01000002_gene1554	2.79e-70	227.0	COG1145@1|root,COG1145@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.3.5.4,1.3.7.1	ko:K00244,ko:K20449	ko00020,ko00190,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164,R03164	RC00045,RC02422	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Fer4,Fer4_7,FrhB_FdhB_C,NADH_4Fe-4S
k59_737307_1	1479237.JMLY01000001_gene1046	4.32e-29	122.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,468GY@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	esterase of the alpha-beta hydrolase superfamily	plpD	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k59_790306_1	95619.PM1_0204790	1.11e-29	114.0	COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,1RNTF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	With MotB forms the ion channels that couple flagellar rotation to proton sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
k59_790306_2	863365.XHC_0537	1.84e-25	103.0	COG1360@1|root,COG1360@2|Bacteria,1MW1Y@1224|Proteobacteria,1RPQ9@1236|Gammaproteobacteria,1X3U0@135614|Xanthomonadales	135614|Xanthomonadales	N	Flagellar motor protein	motB2	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
k59_1616214_1	318996.AXAZ01000033_gene6446	1.48e-98	300.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,3JWIG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_1557989_1	713587.THITH_12375	2.79e-38	133.0	COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,1SAQE@1236|Gammaproteobacteria,1WZIV@135613|Chromatiales	135613|Chromatiales	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
k59_1557989_2	1198232.CYCME_0186	4.19e-47	159.0	COG3663@1|root,COG3663@2|Bacteria,1RAVZ@1224|Proteobacteria,1S2GN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells	mug	-	3.2.2.28	ko:K03649	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_1557989_3	640081.Dsui_0395	9.34e-07	49.3	COG3133@1|root,COG3133@2|Bacteria,1RA1D@1224|Proteobacteria,2VVGJ@28216|Betaproteobacteria,2KZV1@206389|Rhodocyclales	206389|Rhodocyclales	M	Outer membrane lipoprotein	-	-	-	ko:K06077	-	-	-	-	ko00000	-	-	-	-
k59_1143954_1	414684.RC1_2508	2.67e-61	195.0	COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,2U5B6@28211|Alphaproteobacteria,2JRTT@204441|Rhodospirillales	204441|Rhodospirillales	O	maleylacetoacetate isomerase	maiA	-	5.2.1.4	ko:K01801	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R03868	RC00867	ko00000,ko00001,ko01000	-	-	-	GST_C_2,GST_C_3,GST_N,GST_N_3
k59_1143954_2	314264.ROS217_04290	6.68e-17	77.8	COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,2TRTM@28211|Alphaproteobacteria,46P2J@74030|Roseovarius	28211|Alphaproteobacteria	Q	COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)	nagK	-	3.7.1.20	ko:K16165	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R01085	RC00326,RC00446	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
k59_283325_1	1386089.N865_04985	1.81e-95	297.0	COG3158@1|root,COG3158@2|Bacteria,2GMPQ@201174|Actinobacteria,4FIXR@85021|Intrasporangiaceae	201174|Actinobacteria	P	K+ potassium transporter	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_501811_2	243233.MCA3072	1.39e-114	337.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,1XE1F@135618|Methylococcales	135618|Methylococcales	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_501811_3	243233.MCA2148	9.58e-29	115.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1XENK@135618|Methylococcales	135618|Methylococcales	M	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1382211_1	1049564.TevJSym_ac00480	3.87e-133	391.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1J4I6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	JKL	DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlE	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_443193_1	580340.Tlie_0804	1.62e-39	145.0	COG1236@1|root,COG1236@2|Bacteria,3TA98@508458|Synergistetes	508458|Synergistetes	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
k59_930358_1	903818.KI912268_gene1460	2.69e-13	66.6	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	2.7.13.3	ko:K02282,ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035,ko02044	-	-	-	AAA_31,CheW,GGDEF,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_1442233_1	690850.Desaf_1369	4.34e-15	75.9	COG1413@1|root,COG1413@2|Bacteria,1R6G4@1224|Proteobacteria,42T2X@68525|delta/epsilon subdivisions,2WPNC@28221|Deltaproteobacteria,2MANX@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_EZ
k59_1442233_2	1232437.KL662036_gene2708	3.27e-40	136.0	COG0748@1|root,COG0748@2|Bacteria,1N2JV@1224|Proteobacteria,42TYW@68525|delta/epsilon subdivisions,2WQEM@28221|Deltaproteobacteria,2MK6D@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
k59_1791286_1	1121396.KB893100_gene4316	1.18e-92	301.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_1558030_1	396588.Tgr7_3242	2.42e-35	135.0	COG4398@1|root,COG4398@2|Bacteria,1MUX9@1224|Proteobacteria,1RPGR@1236|Gammaproteobacteria,1WWYY@135613|Chromatiales	135613|Chromatiales	S	FIST N domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
k59_443206_1	1304865.JAGF01000001_gene2094	1.52e-70	241.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GM2E@201174|Actinobacteria,4F10D@85016|Cellulomonadaceae	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD2	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1677226_1	1123072.AUDH01000002_gene2534	9.11e-18	80.1	28NIR@1|root,2ZBK2@2|Bacteria,1RAAF@1224|Proteobacteria,2U5XR@28211|Alphaproteobacteria,2JU8G@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1442239_1	1415778.JQMM01000001_gene902	7.81e-39	141.0	COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,1T1NH@1236|Gammaproteobacteria,1J5ZF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Acetyl-coenzyme A transporter 1	ampG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015835,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1901264,GO:1902600	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
k59_1442239_2	1384054.N790_07735	1.76e-18	81.6	2DP15@1|root,3303T@2|Bacteria,1N7NN@1224|Proteobacteria,1S90P@1236|Gammaproteobacteria,1X82G@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4426)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4426
k59_560453_1	1049564.TevJSym_ak00560	3.85e-65	220.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,1J5MJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Ferrous iron transport protein B	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_1734473_1	1167006.UWK_00622	1.04e-30	112.0	COG2204@1|root,COG2204@2|Bacteria,1RHQV@1224|Proteobacteria,42T2A@68525|delta/epsilon subdivisions,2WPA0@28221|Deltaproteobacteria,2MKC4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_1734473_2	880072.Desac_0096	1.7e-14	75.1	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_8,PAS_9,Response_reg,SBP_bac_3
k59_678732_1	1384056.N787_02780	4.95e-47	170.0	COG0591@1|root,COG0642@1|root,COG0745@1|root,COG0591@2|Bacteria,COG0745@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,1X43U@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
k59_1025267_1	309799.DICTH_0721	3.69e-85	277.0	COG2804@1|root,COG2804@2|Bacteria	2|Bacteria	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	ctsE	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
k59_790350_1	926550.CLDAP_41170	6.65e-09	61.6	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	3.1.1.24,3.1.1.85	ko:K01055,ko:K02170	ko00362,ko00780,ko01100,ko01120,ko01220,map00362,map00780,map01100,map01120,map01220	M00568,M00572	R02991,R09725	RC00460,RC00461,RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
k59_1143994_1	483219.LILAB_13360	2.08e-72	232.0	COG0277@1|root,COG0277@2|Bacteria,1MV1Q@1224|Proteobacteria,42MN7@68525|delta/epsilon subdivisions,2WIVK@28221|Deltaproteobacteria,2YYIN@29|Myxococcales	28221|Deltaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
k59_561162_1	1268239.PALB_620	1.71e-65	220.0	COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria,2PZP9@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cusB	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	CusF_Ec,HlyD_D23,HlyD_D4
k59_1507919_1	243233.MCA1000	7.48e-46	157.0	2CAM1@1|root,301FE@2|Bacteria,1RJ36@1224|Proteobacteria,1S7TX@1236|Gammaproteobacteria,1XFDM@135618|Methylococcales	135618|Methylococcales	S	Ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase
k59_1507919_2	1121033.AUCF01000003_gene3500	3.56e-85	260.0	COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,2TVNY@28211|Alphaproteobacteria,2JS9Y@204441|Rhodospirillales	204441|Rhodospirillales	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
k59_1507919_3	1049564.TevJSym_ap00360	7.51e-78	245.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1J4EQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iUTI89_1310.UTI89_C0772,iZ_1308.Z0993	Aminotran_3
k59_1273562_1	272134.KB731324_gene3385	1.78e-60	199.0	COG0438@1|root,COG0438@2|Bacteria,1G27U@1117|Cyanobacteria,1H99H@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_284182_1	2340.JV46_03520	2.04e-119	351.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,1RMUQ@1236|Gammaproteobacteria,1J4P4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iSbBS512_1146.SbBS512_E3351	PGK
k59_1617056_1	1215092.PA6_018_01320	8.43e-10	55.8	COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,1SD8H@1236|Gammaproteobacteria,1YGNB@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0019954,GO:0022402,GO:0022414,GO:0030428,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044464,GO:0051301	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
k59_1617056_2	1240350.AMZE01000013_gene3535	3.23e-71	226.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1YVZJ@136845|Pseudomonas putida group	1236|Gammaproteobacteria	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_1442967_1	479433.Caci_6448	6.2e-67	211.0	2F0VE@1|root,33TX8@2|Bacteria,2INWW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
k59_1383041_1	338966.Ppro_0588	7.64e-13	71.6	COG1009@1|root,COG1009@2|Bacteria,1QV11@1224|Proteobacteria,43CGR@68525|delta/epsilon subdivisions,2X7RW@28221|Deltaproteobacteria	1224|Proteobacteria	C	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K12137	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
k59_1144640_1	247633.GP2143_16566	1.06e-49	171.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1J4GR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	SAM-dependent methyltransferases	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
k59_209626_1	452637.Oter_1552	3.63e-109	345.0	COG3696@1|root,COG3696@2|Bacteria,46SJ1@74201|Verrucomicrobia,3K7EV@414999|Opitutae	414999|Opitutae	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_1677928_1	671143.DAMO_1933	2.55e-81	272.0	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1677931_1	1123257.AUFV01000011_gene3052	1.58e-39	137.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1X3HI@135614|Xanthomonadales	135614|Xanthomonadales	V	N-acetylmuramoyl-L-alanine amidase	ampD	-	3.5.1.28	ko:K01447	-	-	R04112	RC00064,RC00141	ko00000,ko01000	-	-	-	Amidase_2
k59_1677931_2	754477.Q7C_1748	3.03e-38	138.0	COG3103@1|root,COG4991@2|Bacteria,1MX7M@1224|Proteobacteria,1RS74@1236|Gammaproteobacteria,463VV@72273|Thiotrichales	72273|Thiotrichales	T	SH3 domain	-	-	-	ko:K07184	-	-	-	-	ko00000	-	-	-	SH3_3
k59_209645_1	396588.Tgr7_2764	3.7e-103	312.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1WWJH@135613|Chromatiales	135613|Chromatiales	E	peptidase M24B, X-Pro dipeptidase aminopeptidase	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_1507962_1	1267005.KB911257_gene1120	7.13e-70	220.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2TR10@28211|Alphaproteobacteria,3N6HD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Electron transfer flavoprotein, alpha subunit	etfA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
k59_1507962_2	582899.Hden_3413	1.42e-48	161.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2TR4J@28211|Alphaproteobacteria,3N61X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Electron transfer flavoprotein	etfB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_738098_1	555779.Dthio_PD2105	1.12e-128	375.0	COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,43B03@68525|delta/epsilon subdivisions,2X6E6@28221|Deltaproteobacteria,2MH1Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Transposase zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_443978_1	399739.Pmen_0912	3.48e-37	135.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1YDF2@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_1144666_1	435590.BVU_1392	5.15e-15	71.6	COG1610@1|root,COG1610@2|Bacteria,4NQFI@976|Bacteroidetes,2FN46@200643|Bacteroidia,4AQKV@815|Bacteroidaceae	976|Bacteroidetes	S	YqeY-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
k59_990653_1	713587.THITH_00605	9.81e-80	250.0	COG1232@1|root,COG1232@2|Bacteria,1R0KQ@1224|Proteobacteria,1S093@1236|Gammaproteobacteria,1X2HP@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_51521_1	84531.JMTZ01000068_gene1764	1.04e-149	454.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,1RSHX@1236|Gammaproteobacteria,1X3T3@135614|Xanthomonadales	135614|Xanthomonadales	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_790937_1	396588.Tgr7_3044	3.6e-91	273.0	COG0515@1|root,COG0515@2|Bacteria,1NUIB@1224|Proteobacteria	1224|Proteobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_1507969_1	713586.KB900536_gene192	3.96e-96	297.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1WX0K@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5
k59_502612_1	911045.PSE_5009	1.37e-63	199.0	COG2209@1|root,COG2209@2|Bacteria,1R33S@1224|Proteobacteria,2TR3T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrE	-	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
k59_502612_2	1120963.KB894494_gene3372	2.44e-07	52.4	COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,1RPG5@1236|Gammaproteobacteria,2Q0FA@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway	nqrF	GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0048037,GO:0050136,GO:0050660,GO:0050662,GO:0051179,GO:0051234,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071949,GO:0097159,GO:0098796,GO:1901265,GO:1901363,GO:1902494	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
k59_1342890_1	335543.Sfum_2445	1.02e-68	228.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,42M6A@68525|delta/epsilon subdivisions,2WJIT@28221|Deltaproteobacteria,2MQBG@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_1688534_2	484019.THA_1190	4.08e-05	47.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,2GCE3@200918|Thermotogae	200918|Thermotogae	NT	Signal transducing histidine kinase, homodimeric	-	GO:0003674,GO:0005488,GO:0005515,GO:0019904	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
k59_1218282_1	95619.PM1_0221790	1.24e-92	283.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
k59_1111217_1	1121940.AUDZ01000013_gene619	2.19e-54	178.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1XHC3@135619|Oceanospirillales	135619|Oceanospirillales	D	Chromosome partitioning	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_1746204_1	1267005.KB911255_gene2567	3.9e-83	263.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2TUH6@28211|Alphaproteobacteria,3N727@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	STAS domain	MA20_05210	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1520030_1	765913.ThidrDRAFT_0704	3.57e-80	251.0	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,1RQZJ@1236|Gammaproteobacteria,1WX5R@135613|Chromatiales	135613|Chromatiales	I	aromatic hydrocarbon degradation	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_1218290_1	1343740.M271_42445	1.96e-39	136.0	COG2140@1|root,COG2140@2|Bacteria,2IH3Z@201174|Actinobacteria	201174|Actinobacteria	G	Glucose-6-phosphate isomerase (GPI)	-	-	5.3.1.9	ko:K06859	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	GPI
k59_1218290_2	930946.AEOP01000031_gene688	1.92e-15	77.8	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,4H9PH@91061|Bacilli,4AWJG@81850|Leuconostocaceae	91061|Bacilli	EH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_1111219_1	1158150.KB906241_gene1107	1.93e-10	60.5	COG2891@1|root,COG2891@2|Bacteria,1RER7@1224|Proteobacteria,1S8VI@1236|Gammaproteobacteria,1WYH2@135613|Chromatiales	135613|Chromatiales	M	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins	-	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
k59_1037651_1	1415778.JQMM01000001_gene1138	7.55e-24	97.8	COG0811@1|root,COG0811@2|Bacteria,1NXZ9@1224|Proteobacteria,1S154@1236|Gammaproteobacteria,1J4YC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	COG0811 Biopolymer transport proteins	-	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
k59_1037651_3	1121937.AUHJ01000017_gene3009	5.94e-63	213.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVS@1236|Gammaproteobacteria,46674@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA
k59_219895_1	1005048.CFU_0227	1.04e-45	160.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2VIE4@28216|Betaproteobacteria,474WY@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	Transposase DDE domain	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1037656_2	1297742.A176_05859	1.59e-23	98.2	COG5628@1|root,COG5628@2|Bacteria,1PEIJ@1224|Proteobacteria,432V3@68525|delta/epsilon subdivisions,2WXD7@28221|Deltaproteobacteria,2Z02A@29|Myxococcales	28221|Deltaproteobacteria	S	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1801041_2	187272.Mlg_1812	6.54e-50	167.0	COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,1WX0F@135613|Chromatiales	135613|Chromatiales	S	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxH	-	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Metallophos,Metallophos_2
k59_1111226_1	1123368.AUIS01000010_gene2376	9.08e-73	231.0	COG0524@1|root,COG0524@2|Bacteria,1MWX4@1224|Proteobacteria,1RQW6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Phosphorylates 6-deoxy-6-sulfo-D-fructose (SF) to 6- deoxy-6-sulfo-D-fructose 1-phosphate (SFP)	yihV	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006066,GO:0006082,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0034308,GO:0042180,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0061594,GO:0061720,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1901615,GO:1902776,GO:1902777	2.7.1.184,2.7.1.3	ko:K00846,ko:K18478	ko00051,ko01100,ko01120,map00051,map01100,map01120	-	R00866,R03819,R10970	RC00002,RC00017,RC00608	ko00000,ko00001,ko01000,ko04147	-	-	-	PfkB,Rieske
k59_1037660_1	96561.Dole_0105	1.05e-66	209.0	COG0727@1|root,COG0727@2|Bacteria,1REPM@1224|Proteobacteria,42RPZ@68525|delta/epsilon subdivisions,2WNSE@28221|Deltaproteobacteria,2MIBR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
k59_1801043_1	63737.Npun_R6315	1.59e-57	186.0	COG1896@1|root,COG1896@2|Bacteria,1G50J@1117|Cyanobacteria,1HK1Z@1161|Nostocales	1117|Cyanobacteria	S	HD domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
k59_630609_1	1049564.TevJSym_ba00030	2.36e-33	131.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1J4NP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA polymerase III, alpha subunit	dnaE	GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_689822_1	243233.MCA0538	1.52e-101	310.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,1RNKP@1236|Gammaproteobacteria,1XE2Z@135618|Methylococcales	135618|Methylococcales	O	Peptidase, M48	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
k59_1627471_1	768671.ThimaDRAFT_3213	7.58e-60	208.0	COG0642@1|root,COG2204@1|root,COG2204@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1WW92@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_1111238_1	886293.Sinac_7422	2.83e-76	242.0	COG3344@1|root,COG3344@2|Bacteria,2IZGP@203682|Planctomycetes	203682|Planctomycetes	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1
k59_337998_1	177437.HRM2_39230	2.12e-18	82.8	COG1102@1|root,COG1102@2|Bacteria,1R4GX@1224|Proteobacteria,42QKV@68525|delta/epsilon subdivisions,2X6GW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
k59_337998_2	1121396.KB892913_gene163	4.03e-82	260.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2MHKE@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_689827_1	743721.Psesu_1456	3.02e-61	213.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1X46R@135614|Xanthomonadales	135614|Xanthomonadales	E	glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH,GDH_N
k59_338000_1	631362.Thi970DRAFT_01186	4.43e-41	145.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,1WX6R@135613|Chromatiales	135613|Chromatiales	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_338000_2	572477.Alvin_0360	1.71e-33	128.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1WW4U@135613|Chromatiales	135613|Chromatiales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_571622_1	713586.KB900536_gene215	2.92e-18	78.6	COG4517@1|root,COG4517@2|Bacteria,1MZJX@1224|Proteobacteria,1S95D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	IV02_29925	-	-	-	-	-	-	-	-	-	-	-	DUF1820
k59_1569385_1	870187.Thini_0745	1.51e-23	105.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,462CG@72273|Thiotrichales	72273|Thiotrichales	M	Mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM
k59_1154106_1	387093.SUN_1685	6.2e-19	85.1	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2YMAU@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_161726_1	1121372.AULK01000005_gene1573	2.59e-50	169.0	COG1985@1|root,COG1985@2|Bacteria,2GN2P@201174|Actinobacteria,4FNXN@85023|Microbacteriaceae	201174|Actinobacteria	H	RibD C-terminal domain	ribD	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_1393426_1	643562.Daes_1652	3.24e-53	170.0	COG0464@1|root,COG0464@2|Bacteria,1RIMZ@1224|Proteobacteria,43D8F@68525|delta/epsilon subdivisions,2X8F3@28221|Deltaproteobacteria,2MCN5@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_1393426_2	246195.DNO_0181	6.59e-99	317.0	COG1474@1|root,COG1474@2|Bacteria,1R5I2@1224|Proteobacteria,1RXXF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	LO	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1111282_1	1121020.JIAG01000013_gene1316	9.33e-40	142.0	COG3386@1|root,COG3386@2|Bacteria,2GIW1@201174|Actinobacteria,1WATS@1268|Micrococcaceae	201174|Actinobacteria	G	SMP-30/Gluconolaconase/LRE-like region	gnl	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
k59_865817_1	1121396.KB892913_gene162	4.43e-25	109.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MR8@68525|delta/epsilon subdivisions,2WIUA@28221|Deltaproteobacteria,2MPS8@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_1569412_1	1442599.JAAN01000026_gene1282	2.19e-109	332.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1X4IU@135614|Xanthomonadales	135614|Xanthomonadales	S	Protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD	pmbA	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_1746270_1	1458275.AZ34_07940	3.76e-20	90.9	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,4AC0C@80864|Comamonadaceae	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_1746270_2	1265502.KB905935_gene3039	2.52e-31	115.0	COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,2VRZI@28216|Betaproteobacteria,4AE7E@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the skp family	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
k59_865828_1	1168034.FH5T_09180	2.71e-52	174.0	COG1082@1|root,COG1082@2|Bacteria,4NJ3Z@976|Bacteroidetes,2FX90@200643|Bacteroidia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
k59_1393442_1	765912.Thimo_2641	1.06e-65	210.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,1RQQT@1236|Gammaproteobacteria,1WW5C@135613|Chromatiales	135613|Chromatiales	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
k59_865831_1	1122622.ATWJ01000001_gene2549	1.83e-93	294.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria,4FF74@85021|Intrasporangiaceae	201174|Actinobacteria	O	Thioredoxin reductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1520131_1	1125863.JAFN01000001_gene3206	6.06e-121	362.0	COG2159@1|root,COG2159@2|Bacteria,1QZ3W@1224|Proteobacteria,42PKB@68525|delta/epsilon subdivisions,2WM59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_689880_1	1217718.ALOU01000019_gene2587	9.39e-10	59.3	COG0577@1|root,COG0577@2|Bacteria,1P0WE@1224|Proteobacteria,2VMKX@28216|Betaproteobacteria,1K3BC@119060|Burkholderiaceae	28216|Betaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_689880_2	999541.bgla_1g21280	3.04e-25	103.0	COG0577@1|root,COG0577@2|Bacteria,1P0WE@1224|Proteobacteria,2VMKX@28216|Betaproteobacteria,1K3BC@119060|Burkholderiaceae	28216|Betaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1569432_1	756272.Plabr_4330	2.22e-103	317.0	COG1032@1|root,COG1032@2|Bacteria,2J1W3@203682|Planctomycetes	203682|Planctomycetes	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
k59_748777_1	1095767.CAHD01000120_gene2524	2.38e-99	305.0	COG2890@1|root,COG2890@2|Bacteria,2GJPP@201174|Actinobacteria,4F0R9@85016|Cellulomonadaceae	201174|Actinobacteria	J	Ribosomal protein L11 methyltransferase (PrmA)	rsmC	-	-	-	-	-	-	-	-	-	-	-	MTS
k59_454491_1	1232437.KL661976_gene4974	6.91e-66	210.0	COG0484@1|root,COG0484@2|Bacteria,1R1BK@1224|Proteobacteria,43D8A@68525|delta/epsilon subdivisions,2X8EW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Class III cytochrome C family	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII
k59_1111330_1	351348.Maqu_0357	4.8e-35	136.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,4652V@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K01081,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
k59_1111330_2	85643.Tmz1t_1349	5.91e-20	85.5	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHCD@28216|Betaproteobacteria,2KW9G@206389|Rhodocyclales	206389|Rhodocyclales	O	Belongs to the GST superfamily	-	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C
k59_219993_1	583355.Caka_2045	7.82e-09	65.5	COG0771@1|root,COG2911@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	murD	-	3.4.21.10,6.3.2.13,6.3.2.9	ko:K01317,ko:K01925,ko:K01928,ko:K01932	ko00300,ko00471,ko00550,ko01100,map00300,map00471,map00550,map01100	-	R02783,R02788	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01002,ko01011,ko04131	-	-	-	DUF1727,Mur_ligase_C,Mur_ligase_M
k59_219997_1	977880.RALTA_A1536	1.39e-59	205.0	COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2VNDM@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Spermine/spermidine synthase domain	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
k59_748795_1	1121937.AUHJ01000009_gene1553	3.52e-158	459.0	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,1RNS0@1236|Gammaproteobacteria,46ADA@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Cytochrome D1 heme domain	nirS	-	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_513273_1	1003195.SCAT_4647	6.16e-36	129.0	COG0745@1|root,COG0745@2|Bacteria,2GJ2N@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	-	-	-	ko:K02483,ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_513273_2	1386089.N865_04985	3.17e-121	365.0	COG3158@1|root,COG3158@2|Bacteria,2GMPQ@201174|Actinobacteria,4FIXR@85021|Intrasporangiaceae	201174|Actinobacteria	P	K+ potassium transporter	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_1453767_1	765911.Thivi_3087	2.19e-51	173.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1RQ2D@1236|Gammaproteobacteria,1X2F2@135613|Chromatiales	135613|Chromatiales	I	PFAM NAD binding domain of 6-phosphogluconate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_338099_1	933262.AXAM01000013_gene1294	2.95e-51	167.0	COG0746@1|root,COG0746@2|Bacteria,1RKCH@1224|Proteobacteria,42T8X@68525|delta/epsilon subdivisions,2WP3Q@28221|Deltaproteobacteria,2MK7Z@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
k59_1746324_1	1197906.CAJQ02000023_gene2217	4.05e-22	87.8	2EIP1@1|root,33CEE@2|Bacteria,1NE7R@1224|Proteobacteria,2UG1R@28211|Alphaproteobacteria,3K11G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LapA_dom
k59_161807_1	1211115.ALIQ01000002_gene4358	3.25e-53	173.0	COG3707@1|root,COG3707@2|Bacteria,1MXDV@1224|Proteobacteria,2U220@28211|Alphaproteobacteria,3NB3Y@45404|Beijerinckiaceae	28211|Alphaproteobacteria	T	ANTAR	nasT	-	-	ko:K07183	-	-	-	-	ko00000,ko02022	-	-	-	ANTAR,Response_reg
k59_1627583_1	1049564.TevJSym_ah00200	1.63e-111	333.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,1J4TM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	ATPase related to the helicase subunit of the Holliday junction resolvase	rarA	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_1218448_2	471853.Bcav_1169	1.49e-29	118.0	COG1215@1|root,COG1216@1|root,COG1215@2|Bacteria,COG1216@2|Bacteria,2GMQQ@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
k59_1286233_1	706587.Desti_2517	2.8e-16	76.6	COG0664@1|root,COG0664@2|Bacteria,1MZZD@1224|Proteobacteria,42QUX@68525|delta/epsilon subdivisions,2WMWV@28221|Deltaproteobacteria,2MRAE@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	helix_turn_helix, cAMP Regulatory protein	fnr-1	-	-	ko:K01420,ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_689930_1	396588.Tgr7_0570	8.45e-34	125.0	COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria,1WXST@135613|Chromatiales	135613|Chromatiales	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	cpdA	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos
k59_689930_2	459495.SPLC1_S171240	1.27e-06	52.8	COG3735@1|root,COG3735@2|Bacteria,1G6DE@1117|Cyanobacteria	1117|Cyanobacteria	S	TraB family	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
k59_1111388_1	756272.Plabr_1775	2.01e-74	233.0	COG1363@1|root,COG1363@2|Bacteria,2IX7X@203682|Planctomycetes	203682|Planctomycetes	G	Peptidase, m42	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
k59_1111390_1	595494.Tola_0919	4.21e-32	127.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1Y3EB@135624|Aeromonadales	135624|Aeromonadales	S	Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
k59_1746341_2	765952.PUV_26920	3.33e-26	105.0	COG0566@1|root,COG0566@2|Bacteria,2JFQK@204428|Chlamydiae	204428|Chlamydiae	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	spoU_1	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
k59_1111391_1	767817.Desgi_2707	9.53e-41	152.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,260YA@186807|Peptococcaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	ADC,Oxidored_FMN,Pyr_redox_2
k59_1154202_1	1223542.GM1_002_00160	6.39e-13	64.7	2E3M2@1|root,32YJA@2|Bacteria,2GQQW@201174|Actinobacteria,4GEXV@85026|Gordoniaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3107)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3107
k59_1629352_1	96561.Dole_0550	5.96e-83	261.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2MHPV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1039812_1	1266925.JHVX01000011_gene1529	1.69e-24	99.4	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VI5T@28216|Betaproteobacteria,3728G@32003|Nitrosomonadales	28216|Betaproteobacteria	Q	Permease MlaE	ttg2B	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_1039812_2	243233.MCA1967	3.2e-35	125.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,1RQ0Y@1236|Gammaproteobacteria,1XEZ9@135618|Methylococcales	135618|Methylococcales	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_163500_2	396588.Tgr7_2921	1.59e-33	124.0	COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	integral membrane protein	yggT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
k59_1288096_1	596152.DesU5LDRAFT_1367	9.34e-06	48.1	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,42RYH@68525|delta/epsilon subdivisions,2WNT0@28221|Deltaproteobacteria,2MBQC@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1288096_2	928724.SacglDRAFT_01793	0.00018	44.7	COG0697@1|root,COG0697@2|Bacteria,2GNSA@201174|Actinobacteria,4E396@85010|Pseudonocardiales	201174|Actinobacteria	EG	DMT(Drug metabolite transporter) superfamily permease	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1747766_1	1469245.JFBG01000014_gene2027	2.34e-117	350.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RMQB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Tripartite tricarboxylate transporter TctA	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_691453_1	1453501.JELR01000001_gene3135	3.41e-42	147.0	COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,1S2TG@1236|Gammaproteobacteria,466KS@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Beta-lactamase superfamily domain	yycJ	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_347887_1	1449353.JQMQ01000004_gene6183	1.24e-41	156.0	COG0068@1|root,COG0068@2|Bacteria,2GJYF@201174|Actinobacteria,2NGRC@228398|Streptacidiphilus	201174|Actinobacteria	O	HypF finger	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_347887_2	1123242.JH636436_gene18	0.000349	46.6	COG0735@1|root,COG0735@2|Bacteria,2IZJY@203682|Planctomycetes	203682|Planctomycetes	P	Belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_347887_3	1122138.AQUZ01000005_gene2559	1.96e-78	243.0	COG0310@1|root,COG0310@2|Bacteria,2GK2U@201174|Actinobacteria,4DNYF@85009|Propionibacteriales	201174|Actinobacteria	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
k59_699712_1	367299.JOEE01000008_gene591	2e-87	272.0	COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria,4FIIR@85021|Intrasporangiaceae	201174|Actinobacteria	S	Amidohydrolase family	ytcJ	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1051340_1	595593.JREV01000036_gene3551	3.1e-10	66.6	COG2334@1|root,COG2334@2|Bacteria,2I8IC@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_1404547_1	105559.Nwat_1874	2.47e-58	201.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1WW51@135613|Chromatiales	135613|Chromatiales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_699730_1	1089552.KI911559_gene598	5.18e-63	216.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2JPV8@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1042 Acyl-CoA synthetase (NDP forming)	yfiQ	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_230593_1	1123013.AUIC01000002_gene1231	1.07e-07	59.3	COG2852@1|root,COG2852@2|Bacteria,2GNZQ@201174|Actinobacteria,4FPGI@85023|Microbacteriaceae	201174|Actinobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
k59_1051366_1	765911.Thivi_3556	1.48e-91	271.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1S5Y0@1236|Gammaproteobacteria,1WXYX@135613|Chromatiales	135613|Chromatiales	Q	TRAP-type mannitol chloroaromatic compound transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_1051366_2	522306.CAP2UW1_0062	5.5e-12	67.4	COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,2WGS2@28216|Betaproteobacteria,1KR4T@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_230607_1	1178537.BA1_16601	1.05e-14	80.5	COG1508@1|root,COG1508@2|Bacteria,1TQ0H@1239|Firmicutes,4HA8T@91061|Bacilli,1ZBKU@1386|Bacillus	91061|Bacilli	K	COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_1755358_1	349741.Amuc_1222	7.9e-64	214.0	COG1297@1|root,COG1297@2|Bacteria,46TNW@74201|Verrucomicrobia,2IV9P@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
k59_1463718_2	313606.M23134_02374	3.51e-40	142.0	COG4948@1|root,COG4948@2|Bacteria,4NG8N@976|Bacteroidetes,47K7T@768503|Cytophagia	976|Bacteroidetes	M	mandelate racemase muconate lactonizing	-	-	4.2.1.113,5.1.1.20,5.1.1.3	ko:K01776,ko:K02549,ko:K19802	ko00130,ko00471,ko01100,ko01110,map00130,map00471,map01100,map01110	M00116	R00260,R04031,R10938	RC00302,RC01053,RC03309	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	MR_MLE_C,MR_MLE_N
k59_1463725_1	1304865.JAGF01000001_gene2656	7.46e-54	183.0	29B69@1|root,2ZY4N@2|Bacteria,2GKQW@201174|Actinobacteria,4F1XW@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF4350
k59_463608_1	471853.Bcav_2820	2.17e-06	48.9	COG2135@1|root,COG2135@2|Bacteria,2GKY8@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
k59_463608_2	471853.Bcav_2813	1.58e-91	281.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase	dapC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.6.1.1,2.6.1.17	ko:K00812,ko:K14261,ko:K14267	ko00220,ko00250,ko00270,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01130,map01210,map01230	M00016	R00355,R00694,R00734,R00896,R02433,R02619,R04475,R05052	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iNJ661.Rv0858c	Aminotran_1_2
k59_1638390_1	1245469.S58_43820	1.21e-29	111.0	COG0279@1|root,COG0279@2|Bacteria,1NVIE@1224|Proteobacteria,2U8QT@28211|Alphaproteobacteria,3JY4C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	lpcA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
k59_1638390_2	381666.PHG075	5.3e-113	335.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,2VHKM@28216|Betaproteobacteria,1K3JF@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the HypD family	-	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
k59_520462_1	582899.Hden_2345	2.1e-61	212.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,3N69V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
k59_878029_1	926692.AZYG01000085_gene856	1.4e-56	190.0	COG2801@1|root,COG2801@2|Bacteria,1TU21@1239|Firmicutes,249HN@186801|Clostridia,3WA8E@53433|Halanaerobiales	186801|Clostridia	L	Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_878029_2	316273.XCV2263	7.12e-12	63.5	COG2963@1|root,COG2963@2|Bacteria,1N28U@1224|Proteobacteria,1S9BK@1236|Gammaproteobacteria,1XAPX@135614|Xanthomonadales	135614|Xanthomonadales	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1163654_1	1713.JOFV01000008_gene3161	4.86e-107	324.0	COG3288@1|root,COG3288@2|Bacteria,2I2FZ@201174|Actinobacteria,4F0ZY@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM alanine dehydrogenase PNT domain protein	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
k59_230637_1	5059.CADAFLAP00010713	7.98e-08	54.7	KOG0788@1|root,KOG0788@2759|Eukaryota,38CW7@33154|Opisthokonta,3NUFX@4751|Fungi,3QJVK@4890|Ascomycota,20CD1@147545|Eurotiomycetes,3S47Q@5042|Eurotiales	4751|Fungi	T	S-adenosylmethionine decarboxylase	SPE2	GO:0003674,GO:0003824,GO:0004014,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006576,GO:0006595,GO:0006596,GO:0006597,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008215,GO:0008216,GO:0008295,GO:0009058,GO:0009108,GO:0009110,GO:0009308,GO:0009309,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0017144,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0042401,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097164,GO:1901564,GO:1901566,GO:1901576	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	SAM_decarbox
k59_878051_1	1122201.AUAZ01000006_gene3874	7.95e-99	301.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,4644I@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_759794_1	1095743.HMPREF1054_1895	2.97e-33	123.0	COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,1S4C3@1236|Gammaproteobacteria,1Y8H3@135625|Pasteurellales	135625|Pasteurellales	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_1051441_1	1260251.SPISAL_06375	2.65e-17	88.2	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1WWQM@135613|Chromatiales	135613|Chromatiales	P	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1463753_1	768671.ThimaDRAFT_3720	3.54e-74	234.0	COG2270@1|root,COG2270@2|Bacteria,1QX9I@1224|Proteobacteria,1T4WF@1236|Gammaproteobacteria,1X2TX@135613|Chromatiales	135613|Chromatiales	S	PFAM nucleoside H symporter	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
k59_580771_1	765911.Thivi_3439	2.31e-89	273.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1WW4A@135613|Chromatiales	135613|Chromatiales	I	Belongs to the thiolase family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1404617_1	545276.KB898726_gene1044	1.42e-63	209.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1WW0V@135613|Chromatiales	135613|Chromatiales	M	lipoprotein releasing system, transmembrane protein, LolC E family	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_463664_1	1123393.KB891328_gene703	9.44e-10	58.5	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2VIIQ@28216|Betaproteobacteria,1KSPD@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Dehydrogenase E1 component	-	-	-	-	-	-	-	-	-	-	-	-	E1_dh
k59_463664_2	1205680.CAKO01000007_gene4474	8.4e-59	203.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1699926_1	698964.CDPW8_0062	3.51e-205	581.0	COG1249@1|root,COG1249@2|Bacteria,2GJJK@201174|Actinobacteria,22M1A@1653|Corynebacteriaceae	201174|Actinobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	merA	-	1.16.1.1	ko:K00520	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1163715_1	1121403.AUCV01000021_gene3564	9.57e-26	109.0	COG0664@1|root,COG1352@1|root,COG0664@2|Bacteria,COG1352@2|Bacteria,1R5Z0@1224|Proteobacteria,42Q0Q@68525|delta/epsilon subdivisions,2WKKJ@28221|Deltaproteobacteria,2MI6B@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Putative methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_20,cNMP_binding
k59_348019_1	1121405.dsmv_0141	4.45e-104	313.0	COG0247@1|root,COG0247@2|Bacteria,1R467@1224|Proteobacteria,42NIQ@68525|delta/epsilon subdivisions,2WIUU@28221|Deltaproteobacteria,2MQ10@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	hmcF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17
k59_520501_1	530564.Psta_4193	2.81e-105	329.0	COG0433@1|root,COG0433@2|Bacteria,2IY71@203682|Planctomycetes	203682|Planctomycetes	L	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87,PDDEXK_1
k59_1051500_1	876044.IMCC3088_894	9.45e-157	463.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_1581261_1	522306.CAP2UW1_2799	1.82e-93	299.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.9	ko:K01539	ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978	-	-	-	ko00000,ko00001,ko01000,ko04147	3.A.3.1	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_463688_1	367299.JOEE01000008_gene610	1.9e-119	350.0	COG2378@1|root,COG2378@2|Bacteria,2GM46@201174|Actinobacteria,4FFEG@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	pafB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K13572,ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
k59_348028_1	1230476.C207_02402	1.62e-26	98.6	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,3K050@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Ribonuclease B OB domain	cspA1	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_1699944_1	400682.PAC_15706126	1.89e-93	289.0	COG0129@1|root,KOG2448@2759|Eukaryota,38F28@33154|Opisthokonta,3BY2D@33208|Metazoa	33208|Metazoa	E	Dehydratase family	-	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_174772_1	1265313.HRUBRA_01185	4.07e-108	323.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1J4EX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	iG2583_1286.G2583_3081	SHMT
k59_761798_1	857087.Metme_2689	1.75e-25	101.0	COG0209@1|root,COG0209@2|Bacteria,1P4EH@1224|Proteobacteria,1RP1A@1236|Gammaproteobacteria,1XE5D@135618|Methylococcales	135618|Methylococcales	F	COG0209 Ribonucleotide reductase, alpha subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_761798_2	1385515.N791_13170	4.3e-312	867.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1X2Z8@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_701633_1	1184609.KILIM_003_01260	1.28e-84	264.0	COG4320@1|root,COG4320@2|Bacteria,2GKEK@201174|Actinobacteria	201174|Actinobacteria	K	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
k59_349845_1	247634.GPB2148_3730	1.29e-64	209.0	COG0258@1|root,COG0258@2|Bacteria,1RAAR@1224|Proteobacteria,1RN1S@1236|Gammaproteobacteria,1J5ZC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	COG0258 5'-3' exonuclease (including N-terminal domain of PolI)	exo	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
k59_809045_2	561230.PC1_2402	1.9e-29	115.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,1MR2E@122277|Pectobacterium	1236|Gammaproteobacteria	H	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_1757116_1	794903.OPIT5_07180	8.58e-58	182.0	COG0745@1|root,COG0745@2|Bacteria,46VXW@74201|Verrucomicrobia	74201|Verrucomicrobia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_641344_1	1032480.MLP_32030	1.93e-42	156.0	COG5278@1|root,COG5278@2|Bacteria,2GJ1Q@201174|Actinobacteria,4DQKD@85009|Propionibacteriales	201174|Actinobacteria	T	phosphoserine phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_465895_1	398767.Glov_1392	1.36e-61	212.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43U04@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1054140_1	109760.SPPG_05689T0	9.09e-05	52.0	COG0553@1|root,KOG0388@2759|Eukaryota,3AIZX@33154|Opisthokonta,3NVFX@4751|Fungi	4751|Fungi	L	DNA helicase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair	INO80	GO:0000228,GO:0000722,GO:0000723,GO:0000785,GO:0000790,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006312,GO:0006323,GO:0006325,GO:0006333,GO:0006338,GO:0006342,GO:0006348,GO:0006351,GO:0006355,GO:0006357,GO:0006366,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010646,GO:0010647,GO:0016043,GO:0016070,GO:0016458,GO:0016462,GO:0016584,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031011,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031497,GO:0031974,GO:0031981,GO:0032101,GO:0032103,GO:0032104,GO:0032106,GO:0032107,GO:0032109,GO:0032200,GO:0032392,GO:0032508,GO:0032774,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0034728,GO:0040029,GO:0042592,GO:0042623,GO:0042766,GO:0043044,GO:0043138,GO:0043140,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043486,GO:0043618,GO:0043620,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0045814,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045944,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051276,GO:0051716,GO:0051983,GO:0060249,GO:0060255,GO:0060303,GO:0065007,GO:0065008,GO:0070013,GO:0070035,GO:0070603,GO:0071103,GO:0071704,GO:0071824,GO:0071840,GO:0080040,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097346,GO:0097659,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1904949,GO:2000112,GO:2000113,GO:2001141	2.1.1.313,3.6.4.12	ko:K11665,ko:K19307	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	DBINO,Helicase_C,SNF2_N
k59_880257_1	1232410.KI421425_gene1552	9.21e-86	283.0	COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
k59_174801_1	1123070.KB899265_gene1827	3.12e-11	62.8	COG0229@1|root,COG0229@2|Bacteria,46TM8@74201|Verrucomicrobia,2IUM0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	SelR domain	-	-	-	-	-	-	-	-	-	-	-	-	SelR
k59_1757135_1	1128421.JAGA01000002_gene1975	3.41e-28	116.0	COG1132@1|root,COG1132@2|Bacteria,2NQH2@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1757135_2	1268068.PG5_28370	1.35e-09	58.9	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	JD73_00825	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1406109_1	765910.MARPU_07295	1e-32	123.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,1RR44@1236|Gammaproteobacteria,1WVVH@135613|Chromatiales	135613|Chromatiales	S	Methyltransferase	-	-	2.1.1.44	ko:K18911	ko00340,map00340	-	R01169	RC00003,RC02308	ko00000,ko00001,ko01000	-	-	-	Methyltransf_33
k59_349896_1	471853.Bcav_1987	2.33e-34	124.0	COG1051@1|root,COG1051@2|Bacteria,2I2K3@201174|Actinobacteria	201174|Actinobacteria	F	Belongs to the NUDIX hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_349896_2	446471.Xcel_1664	2.4e-90	271.0	COG0311@1|root,COG0311@2|Bacteria,2GNYG@201174|Actinobacteria,4F376@85017|Promicromonosporaceae	201174|Actinobacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
k59_809087_1	435908.IDSA_02230	4.28e-50	164.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria,2QG3U@267893|Idiomarinaceae	1236|Gammaproteobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046983,GO:0070037,GO:0070038,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
k59_809087_2	713586.KB900536_gene1093	5.01e-10	58.5	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,1WY2J@135613|Chromatiales	135613|Chromatiales	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_701693_2	1279019.ARQK01000042_gene2023	3.02e-37	137.0	COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,1S04A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	glycosyl transferase group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
k59_1582808_1	590998.Celf_1403	1.25e-34	122.0	COG0698@1|root,COG0698@2|Bacteria,2GKJG@201174|Actinobacteria,4F170@85016|Cellulomonadaceae	201174|Actinobacteria	G	isomerase, RpiB LacA LacB family	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
k59_1582808_2	935839.JAGJ01000027_gene2815	4.71e-23	97.4	COG4552@1|root,COG4552@2|Bacteria,2GNXZ@201174|Actinobacteria,4F4QA@85017|Promicromonosporaceae	201174|Actinobacteria	S	N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
k59_349906_1	187272.Mlg_2451	1.92e-37	144.0	COG3221@1|root,COG5001@1|root,COG3221@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVV9@135613|Chromatiales	135613|Chromatiales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_9,Phosphonate-bd,Response_reg
k59_232658_1	472759.Nhal_3526	3.57e-114	344.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1WW1X@135613|Chromatiales	135613|Chromatiales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
k59_1231631_1	710696.Intca_2697	1.69e-65	212.0	COG1175@1|root,COG1175@2|Bacteria,2GKYS@201174|Actinobacteria,4FEB9@85021|Intrasporangiaceae	201174|Actinobacteria	G	ABC transporter (Permease)	-	-	-	ko:K10233	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
k59_1812070_1	1206733.BAGC01000048_gene2372	8.01e-77	263.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4G0D1@85025|Nocardiaceae	201174|Actinobacteria	S	ABC1 family	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
k59_174859_1	675635.Psed_4712	1.89e-85	263.0	COG0743@1|root,COG0743@2|Bacteria,2GIRV@201174|Actinobacteria,4DY4I@85010|Pseudonocardiales	201174|Actinobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2870c	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_880327_1	272123.Anacy_5365	8.76e-23	102.0	COG1404@1|root,COG1404@2|Bacteria,1GCJB@1117|Cyanobacteria	1117|Cyanobacteria	O	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_701709_1	316274.Haur_3400	0.000491	47.8	COG0406@1|root,COG0406@2|Bacteria,2G73Q@200795|Chloroflexi,37737@32061|Chloroflexia	32061|Chloroflexia	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_1406146_1	396588.Tgr7_2003	2.65e-45	155.0	COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,1S9FW@1236|Gammaproteobacteria,1WXHE@135613|Chromatiales	135613|Chromatiales	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
k59_1812084_1	644107.SL1157_0788	8.5e-42	154.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2TRWK@28211|Alphaproteobacteria,4NB3E@97050|Ruegeria	28211|Alphaproteobacteria	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_1166182_1	768671.ThimaDRAFT_0815	4.39e-71	233.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,1WXVP@135613|Chromatiales	135613|Chromatiales	P	PFAM von Willebrand factor type A	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_2
k59_1701892_1	987059.RBXJA2T_09542	5.62e-44	150.0	COG2227@1|root,COG2227@2|Bacteria,1N2VZ@1224|Proteobacteria,2VQ4X@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Magnesium-protoporphyrin IX methyltransferase C-terminus	-	-	2.1.1.11	ko:K03428	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R04237	RC00003,RC00460	ko00000,ko00001,ko01000	-	-	-	MTS,Mg-por_mtran_C
k59_1701892_2	1112214.AHIS01000046_gene2247	1.82e-50	174.0	COG0477@1|root,COG2814@2|Bacteria,1MW95@1224|Proteobacteria,2TS8H@28211|Alphaproteobacteria,2K2JK@204457|Sphingomonadales	204457|Sphingomonadales	EGP	PUCC protein	-	-	-	ko:K08226	-	-	-	-	ko00000,ko02000	2.A.1.41	-	-	PUCC
k59_349932_1	1193181.BN10_880002	2.11e-109	329.0	COG1282@1|root,COG1282@2|Bacteria,2GNKB@201174|Actinobacteria,4FECY@85021|Intrasporangiaceae	201174|Actinobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_1757193_1	344747.PM8797T_11514	1.14e-26	115.0	COG0834@1|root,COG1301@1|root,COG0834@2|Bacteria,COG1301@2|Bacteria	2|Bacteria	C	dicarboxylic acid transport	-	-	-	ko:K02030,ko:K11102	-	M00236	-	-	ko00000,ko00002,ko02000	2.A.23.1.1,2.A.23.1.2,3.A.1.3	-	-	HATPase_c,HisKA_3,PAS_3,PAS_4,PAS_9,SBP_bac_3,SDF
k59_1701895_1	446466.Cfla_2908	5.22e-107	322.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4F0I7@85016|Cellulomonadaceae	201174|Actinobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0008150,GO:0040007	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
k59_465997_1	868595.Desca_0352	1.36e-07	54.7	COG0068@1|root,COG0068@2|Bacteria,1TQM7@1239|Firmicutes,2494A@186801|Clostridia,260CF@186807|Peptococcaceae	186801|Clostridia	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_465997_2	1049564.TevJSym_al00340	1.59e-96	290.0	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,1RQBE@1236|Gammaproteobacteria,1JA5R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	AIR synthase related protein, N-terminal domain	hypE	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0018193,GO:0018198,GO:0018249,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046892,GO:0051604,GO:0071704,GO:1901564	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
k59_1406154_1	1267005.KB911257_gene986	2.04e-78	258.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria,3N6KE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_1757199_1	1317124.DW2_08422	3.57e-18	86.7	2D1VK@1|root,32TBH@2|Bacteria,1N3ZJ@1224|Proteobacteria,2UDBM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1231668_1	553178.CAPGI0001_1058	4.79e-33	134.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,4NDVA@976|Bacteroidetes,1HXMT@117743|Flavobacteriia,1EQXN@1016|Capnocytophaga	976|Bacteroidetes	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1295051_1	574966.KB898651_gene2140	6.74e-38	144.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_62275_1	367299.JOEE01000001_gene1877	2.53e-129	374.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4FED3@85021|Intrasporangiaceae	201174|Actinobacteria	E	L-threonine 3-dehydrogenase	tdh	-	1.1.1.103,1.1.1.380	ko:K00060,ko:K08322	ko00040,ko00260,ko01100,map00040,map00260,map01100	-	R01465,R10848	RC00085,RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_355744_1	1049564.TevJSym_ad00030	6.18e-50	171.0	COG1216@1|root,COG1216@2|Bacteria,1R6SJ@1224|Proteobacteria,1RQQW@1236|Gammaproteobacteria,1J82R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_62276_1	765911.Thivi_2221	1.03e-103	315.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1WWNX@135613|Chromatiales	135613|Chromatiales	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_1059254_1	1232437.KL662020_gene705	2.26e-69	224.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_471899_1	345341.KUTG_00857	1.78e-21	95.1	COG3547@1|root,COG3547@2|Bacteria,2ID3X@201174|Actinobacteria	201174|Actinobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1176405_1	926550.CLDAP_13750	2.04e-41	155.0	COG1404@1|root,COG1404@2|Bacteria,2G7GP@200795|Chloroflexi	200795|Chloroflexi	M	LPXTG-motif cell wall anchor domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
k59_1295076_2	870187.Thini_2380	5.84e-11	67.0	COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,1RSQ1@1236|Gammaproteobacteria,460MY@72273|Thiotrichales	72273|Thiotrichales	S	Zn-dependent protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_471905_1	933262.AXAM01000024_gene741	3.18e-71	224.0	COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,42M16@68525|delta/epsilon subdivisions,2WM0V@28221|Deltaproteobacteria,2MKMA@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Amino acid kinase family	cpkA	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_355769_1	163908.KB235896_gene3743	1.31e-11	61.2	COG0724@1|root,COG0724@2|Bacteria,1G7Q7@1117|Cyanobacteria,1HP3U@1161|Nostocales	1117|Cyanobacteria	S	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_1411204_1	1265502.KB905936_gene2654	1.48e-06	47.4	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,2VSDV@28216|Betaproteobacteria,4AECQ@80864|Comamonadaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
k59_238331_1	1388763.O165_018940	1.32e-49	167.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,1RN90@1236|Gammaproteobacteria,1YVT4@136845|Pseudomonas putida group	1236|Gammaproteobacteria	M	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02464,ko:K02654	ko03070,map03070	M00331	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
k59_944177_1	768671.ThimaDRAFT_4355	1.01e-47	172.0	COG5421@1|root,COG5421@2|Bacteria,1R6MI@1224|Proteobacteria,1SKFJ@1236|Gammaproteobacteria,1X099@135613|Chromatiales	135613|Chromatiales	L	COG0841 Cation multidrug efflux pump	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1060149_1	1446473.JHWH01000003_gene3266	1.22e-37	135.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2U2G6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	transposase IS116 IS110 IS902 family protein	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1764069_2	977880.RALTA_A0161	3.6e-08	55.5	COG2223@1|root,COG2223@2|Bacteria,1QU4X@1224|Proteobacteria,2WH87@28216|Betaproteobacteria,1KIIC@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Acetyl-coenzyme A transporter 1	ampG	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	Acatn,MFS_1
k59_1296409_1	396588.Tgr7_3089	1.54e-68	233.0	COG0439@1|root,COG1984@1|root,COG2049@1|root,COG4770@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,COG4770@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,1WX8J@135613|Chromatiales	135613|Chromatiales	EI	Allophanate hydrolase subunit 1	-	-	6.3.4.6	ko:K01941	ko00220,ko00791,ko01100,map00220,map00791,map01100	-	R00774	RC00378	ko00000,ko00001,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D
k59_296764_1	1122933.JNIY01000003_gene460	2.03e-86	273.0	COG1251@1|root,COG1251@2|Bacteria,2GJ3U@201174|Actinobacteria,4F0F5@85016|Cellulomonadaceae	201174|Actinobacteria	C	BFD-like [2Fe-2S] binding domain	nasC	-	-	ko:K00360	ko00910,ko01120,map00910,map01120	M00531	R00798	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Pyr_redox_2
k59_531568_1	1121918.ARWE01000001_gene2227	8.38e-40	143.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,42NWB@68525|delta/epsilon subdivisions,2WKKE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	von Willebrand factor, type A	batA	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA
k59_531568_2	768671.ThimaDRAFT_4340	4.35e-35	135.0	COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1WWHI@135613|Chromatiales	135613|Chromatiales	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	TPR_1,TPR_16,VWA_2
k59_238343_1	1121405.dsmv_1603	1.56e-51	164.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,42TPU@68525|delta/epsilon subdivisions,2WQ1M@28221|Deltaproteobacteria,2MKJV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_238343_2	1265507.KB899638_gene967	0.000257	42.7	COG0492@1|root,COG3634@1|root,COG0492@2|Bacteria,COG3634@2|Bacteria,1MV15@1224|Proteobacteria,1SNTW@1236|Gammaproteobacteria,1Y6IK@135624|Aeromonadales	135624|Aeromonadales	O	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Thioredoxin_3
k59_238346_1	177437.HRM2_15530	1.18e-62	209.0	COG0668@1|root,COG3064@1|root,COG0668@2|Bacteria,COG3064@2|Bacteria,1N596@1224|Proteobacteria,42Z9C@68525|delta/epsilon subdivisions,2WUFQ@28221|Deltaproteobacteria,2MN3G@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel
k59_765947_1	935839.JAGJ01000004_gene1936	1.87e-109	325.0	COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,4F464@85017|Promicromonosporaceae	201174|Actinobacteria	C	Dehydrogenase E1 component	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_1118230_1	929558.SMGD1_0009	3.04e-51	179.0	28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,42NVF@68525|delta/epsilon subdivisions,2YR6H@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	G	Fatty acid cis trans isomerase	-	-	-	-	-	-	-	-	-	-	-	-	CTI
k59_707703_1	1380394.JADL01000001_gene2059	5.83e-82	265.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,2JQPG@204441|Rhodospirillales	204441|Rhodospirillales	O	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_1,TPR_16,TPR_2,TPR_8
k59_1177289_1	1144275.COCOR_00321	1.68e-08	55.8	COG3833@1|root,COG3833@2|Bacteria,1QA3Z@1224|Proteobacteria,42R4X@68525|delta/epsilon subdivisions,2WN1E@28221|Deltaproteobacteria,2YU8W@29|Myxococcales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10110,ko:K15772	ko02010,map02010	M00194,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22	-	-	BPD_transp_1
k59_1177289_2	290397.Adeh_4135	3.11e-58	196.0	COG1175@1|root,COG1175@2|Bacteria,1MXKR@1224|Proteobacteria,42UM4@68525|delta/epsilon subdivisions,2WQPJ@28221|Deltaproteobacteria,2YUAR@29|Myxococcales	28221|Deltaproteobacteria	P	Sugar ABC transporter permease	malF	-	-	ko:K10109,ko:K15770,ko:K15771	ko02010,map02010	M00194,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22	-	-	BPD_transp_1,SBP_bac_8
k59_1824580_1	1300345.LF41_2765	7.27e-137	428.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1X3ME@135614|Xanthomonadales	135614|Xanthomonadales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_179265_1	211165.AJLN01000134_gene5782	1.96e-66	216.0	COG0076@1|root,COG0076@2|Bacteria,1GD62@1117|Cyanobacteria,1JME6@1189|Stigonemataceae	1117|Cyanobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
k59_885471_1	118166.JH976537_gene1439	1.09e-16	87.0	COG0845@1|root,COG0845@2|Bacteria,1FZZ9@1117|Cyanobacteria,1H77A@1150|Oscillatoriales	1117|Cyanobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
k59_1296453_1	1298867.AUES01000001_gene1709	2.91e-78	249.0	COG0074@1|root,COG0074@2|Bacteria,1MWWN@1224|Proteobacteria,2TTYT@28211|Alphaproteobacteria,3JXIV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CoA-ligase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding,Ligase_CoA
k59_1705622_1	1304878.AUGD01000006_gene6636	1.19e-27	115.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_179266_1	880072.Desac_2717	3.72e-22	98.6	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,42M4X@68525|delta/epsilon subdivisions,2WJJY@28221|Deltaproteobacteria,2MQC0@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
k59_4268_1	1123400.KB904747_gene622	9.1e-84	265.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,4629A@72273|Thiotrichales	72273|Thiotrichales	P	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
k59_1529308_1	439235.Dalk_2050	3.69e-95	286.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WJYV@28221|Deltaproteobacteria,2MJ0G@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_472808_1	1379270.AUXF01000002_gene1329	1.75e-15	82.8	COG1404@1|root,COG1404@2|Bacteria,1ZUQ8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_944238_1	765910.MARPU_08080	4.49e-56	187.0	COG0596@1|root,COG0596@2|Bacteria,1RGAP@1224|Proteobacteria,1S1M7@1236|Gammaproteobacteria,1WXIZ@135613|Chromatiales	135613|Chromatiales	S	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_357119_1	566466.NOR53_3321	1.6e-43	160.0	COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,1RPD2@1236|Gammaproteobacteria,1J4T5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_16,TPR_19,TPR_20,TPR_8
k59_1118250_2	1265502.KB905935_gene3120	1.22e-26	110.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2VING@28216|Betaproteobacteria,4AAXB@80864|Comamonadaceae	28216|Betaproteobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
k59_707730_1	1267005.KB911265_gene3587	1.08e-58	191.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2TSXA@28211|Alphaproteobacteria,3N6TC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	OU	signal peptide peptidase SppA, 36K type	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_238379_1	1049564.TevJSym_bp00150	3.84e-92	277.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1J4QF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.6,2.1.3.9	ko:K00611,ko:K09065,ko:K13252	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_296807_1	768671.ThimaDRAFT_4734	1.77e-89	278.0	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,1WW9T@135613|Chromatiales	135613|Chromatiales	P	PFAM Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_179273_1	794903.OPIT5_04570	3.59e-38	145.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	irp	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_4292_1	1121405.dsmv_1445	7.49e-118	353.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2MI6Q@213118|Desulfobacterales	28221|Deltaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_885502_1	446466.Cfla_1061	4.02e-129	377.0	COG0216@1|root,COG0216@2|Bacteria,2GJWG@201174|Actinobacteria,4F11I@85016|Cellulomonadaceae	201174|Actinobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	GO:0008150,GO:0040007	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_765979_1	446462.Amir_1413	1.18e-06	50.8	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4E13K@85010|Pseudonocardiales	201174|Actinobacteria	L	DEAD DEAH box helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
k59_765979_2	290399.Arth_1459	2.51e-15	70.5	2EFU9@1|root,339KE@2|Bacteria,2GQJW@201174|Actinobacteria,1WA02@1268|Micrococcaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3046)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3046
k59_1412125_1	335543.Sfum_1941	3.74e-82	253.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria,2MR9Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_531598_2	130478.Q9B0D2_9CAUD	1.2e-40	171.0	4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses  no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae	10699|Siphoviridae	S	peptidoglycan catabolic process	-	GO:0008150,GO:0016032,GO:0019058,GO:0019068,GO:0044403,GO:0044419,GO:0051704,GO:0098003	-	-	-	-	-	-	-	-	-	-	-
k59_357139_1	314285.KT71_07244	1.84e-41	148.0	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,1RMP3@1236|Gammaproteobacteria,1J85J@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0031647,GO:0036506,GO:0042026,GO:0042802,GO:0043167,GO:0043169,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0065007,GO:0065008	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
k59_357139_2	519989.ECTPHS_09268	6.08e-43	152.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1WX4J@135613|Chromatiales	135613|Chromatiales	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_472826_1	1304865.JAGF01000001_gene2637	3.23e-34	135.0	COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria,4F0RD@85016|Cellulomonadaceae	201174|Actinobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_1177316_1	391615.ABSJ01000045_gene2017	7.73e-49	162.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,1RPK3@1236|Gammaproteobacteria,1J5S9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006515,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019538,GO:0030163,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0052689,GO:0071704,GO:0140098,GO:0140101,GO:1901564,GO:1901565,GO:1901575	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
k59_885507_2	1049564.TevJSym_aj00510	8.45e-57	191.0	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,1J6D6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Citrate transporter	nhaD	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_4304_1	1454004.AW11_00566	1.34e-83	254.0	COG1392@1|root,COG1392@2|Bacteria,1MXY9@1224|Proteobacteria	1224|Proteobacteria	P	Phosphate transport regulator (Distant homolog of PhoU)	UF78_21250	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_1236056_1	105425.BBPL01000064_gene5313	7.39e-75	240.0	COG0702@1|root,COG0702@2|Bacteria,2GIZA@201174|Actinobacteria,2NGHW@228398|Streptacidiphilus	201174|Actinobacteria	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
k59_1296496_1	1316927.ATKI01000045_gene3167	8.92e-113	332.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1YMJP@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0030145,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2436,iBWG_1329.BWG_2198,iECDH10B_1368.ECDH10B_2601,iECDH1ME8569_1439.ECDH1ME8569_2370,iETEC_1333.ETEC_2549,iEcDH1_1363.EcDH1_1225,iEcHS_1320.EcHS_A2573,iEcolC_1368.EcolC_1243,iJO1366.b2436,iJR904.b2436,iY75_1357.Y75_RS12760	Coprogen_oxidas
k59_1824636_1	880073.Calab_3608	1.36e-71	232.0	COG0471@1|root,COG0471@2|Bacteria,2NPNA@2323|unclassified Bacteria	2|Bacteria	P	Sodium:sulfate symporter transmembrane region	sdcS	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0034220,GO:0044425,GO:0051179,GO:0051234,GO:0055085,GO:0098656	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
k59_120688_1	471853.Bcav_0565	6.75e-117	353.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GJW4@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase S9 prolyl oligopeptidase active site domain protein	-	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S9
k59_824759_1	2340.JV46_24010	4.12e-149	447.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RMPV@1236|Gammaproteobacteria,1J4WG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_885519_1	1260251.SPISAL_06825	1.77e-176	506.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1WW6B@135613|Chromatiales	135613|Chromatiales	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_885519_2	396588.Tgr7_0769	1.4e-103	315.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1WWB9@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_590383_1	1267005.KB911255_gene2707	2.66e-12	71.2	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,1PJRR@1224|Proteobacteria,2U625@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	DUF4189,PG_binding_1,Pkinase,WD40
k59_590383_2	582899.Hden_0064	3.22e-10	58.9	COG3921@1|root,COG3921@2|Bacteria,1N3WR@1224|Proteobacteria,2U1ZC@28211|Alphaproteobacteria,3N8P2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Extensin family	-	-	-	-	-	-	-	-	-	-	-	-	Extensin-like_C
k59_1060237_1	991905.SL003B_2065	1.1e-133	403.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,4BPJT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1236073_1	497964.CfE428DRAFT_3356	4.16e-56	188.0	COG0700@1|root,COG2715@1|root,COG0700@2|Bacteria,COG2715@2|Bacteria,46TMH@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Nucleoside recognition	-	-	-	-	-	-	-	-	-	-	-	-	Gate
k59_1824650_1	631362.Thi970DRAFT_00980	7.22e-35	128.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,1WWXZ@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
k59_1118278_1	1121933.AUHH01000015_gene439	1.3e-05	45.4	COG0139@1|root,COG0139@2|Bacteria,2IKKU@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	GO:0008150,GO:0040007	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1606	PRA-CH
k59_1118278_2	1035308.AQYY01000001_gene3294	1e-184	521.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_1647156_1	479433.Caci_6561	4.1e-09	62.4	COG4221@1|root,COG4221@2|Bacteria,2ID7Y@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_238417_1	631362.Thi970DRAFT_02073	3.17e-42	150.0	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,1WWFE@135613|Chromatiales	135613|Chromatiales	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
k59_885527_1	1286106.MPL1_11683	6.62e-57	202.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,45ZVU@72273|Thiotrichales	72273|Thiotrichales	M	PFAM AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA
k59_1529350_1	743718.Isova_2567	2.2e-57	197.0	COG0438@1|root,COG0438@2|Bacteria,2I005@201174|Actinobacteria	201174|Actinobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_472862_1	381666.H16_A1621	4.57e-37	140.0	COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2VNDM@28216|Betaproteobacteria,1KBX2@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Spermine/spermidine synthase domain	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
k59_769883_2	870187.Thini_0666	1.7e-33	122.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,1RS0S@1236|Gammaproteobacteria,460HP@72273|Thiotrichales	72273|Thiotrichales	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine	-	-	2.4.2.44	ko:K19696	ko00270,ko01100,map00270,map01100	-	R09668	RC00063	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3,PNP_UDP_1
k59_1358042_1	105559.Nwat_0935	5.84e-43	157.0	COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1WXKG@135613|Chromatiales	135613|Chromatiales	DM	mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM,MscS_porin
k59_1358042_2	1232683.ADIMK_1166	8.32e-21	93.2	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,464FF@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Belongs to the peptidase S16 family	ycbZ	-	-	ko:K04770	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C
k59_246569_1	106370.Francci3_3987	1.31e-134	402.0	COG1073@1|root,COG1926@1|root,COG1073@2|Bacteria,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,4ES6H@85013|Frankiales	201174|Actinobacteria	S	Phosphoribosyl transferase domain	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
k59_951163_1	1123054.KB907715_gene47	1.67e-26	100.0	COG0607@1|root,COG0607@2|Bacteria,1MZ87@1224|Proteobacteria,1S98V@1236|Gammaproteobacteria,1X1QU@135613|Chromatiales	135613|Chromatiales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1652109_1	396588.Tgr7_1832	2.46e-78	249.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WW5M@135613|Chromatiales	135613|Chromatiales	EH	Anthranilate synthase component I	-	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_829768_1	446471.Xcel_2463	3.13e-76	238.0	COG0083@1|root,COG0083@2|Bacteria,2GKIW@201174|Actinobacteria,4F427@85017|Promicromonosporaceae	201174|Actinobacteria	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_1652110_1	395493.BegalDRAFT_1677	1.64e-81	263.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,45ZV1@72273|Thiotrichales	72273|Thiotrichales	O	ATP-dependent Clp protease ATP-binding subunit ClpA	-	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1710102_1	1192759.AKIB01000037_gene3262	2.8e-39	144.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2JZZ6@204457|Sphingomonadales	204457|Sphingomonadales	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1710102_2	1041139.KB902703_gene2331	1.89e-49	164.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TS16@28211|Alphaproteobacteria,4BB8M@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	IstB-like ATP binding protein	MA20_10895	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_1242237_1	745310.G432_03260	3.33e-65	215.0	COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,2TQVA@28211|Alphaproteobacteria,2K1FH@204457|Sphingomonadales	204457|Sphingomonadales	U	alanine symporter	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_1066779_1	269800.Tfu_3106	6.23e-16	76.3	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,4EFSA@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma-70 region 2	sigM	GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1066779_2	1191523.MROS_0324	7.98e-08	51.6	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	hup_1	-	-	ko:K03530,ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_1477245_1	376733.IT41_12385	1.21e-61	195.0	COG5618@1|root,COG5618@2|Bacteria,1RC24@1224|Proteobacteria,2U7AA@28211|Alphaproteobacteria,2PX5F@265|Paracoccus	28211|Alphaproteobacteria	S	Predicted periplasmic lipoprotein (DUF2291)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2291
k59_1477245_2	1041146.ATZB01000005_gene6056	1.04e-19	88.2	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria,4BC4A@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ATPases associated with a variety of cellular activities	-	-	-	ko:K17204	ko02010,map02010	M00590	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.11,3.A.1.2.16	-	-	ABC_tran
k59_1066783_1	866776.HMPREF9321_0369	4.21e-18	78.6	COG1869@1|root,COG1869@2|Bacteria,1VA2V@1239|Firmicutes,4H5HR@909932|Negativicutes	909932|Negativicutes	G	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose	rbsD	-	5.4.99.62	ko:K06726	ko02010,map02010	-	R08247	RC02247	ko00000,ko00001,ko01000	-	-	-	RbsD_FucU
k59_1066783_2	593907.Celgi_1262	0.000315	46.6	COG0524@1|root,COG0524@2|Bacteria,2GQ7J@201174|Actinobacteria,4F2FV@85016|Cellulomonadaceae	201174|Actinobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.187	ko:K19978	ko00525,ko01130,map00525,map01130	-	R11184	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_1242244_1	95619.PM1_0201860	3.34e-40	143.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Signal transduction histidine kinase, nitrogen specific	glnL	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
k59_1242244_2	572477.Alvin_2997	8.47e-86	268.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WW4B@135613|Chromatiales	135613|Chromatiales	T	response regulator	glnG	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_125544_1	471853.Bcav_2734	2.25e-98	292.0	COG0689@1|root,COG0689@2|Bacteria,2GJFI@201174|Actinobacteria	201174|Actinobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
k59_418740_1	1123253.AUBD01000008_gene470	6.05e-65	210.0	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,1RPJA@1236|Gammaproteobacteria,1X57R@135614|Xanthomonadales	135614|Xanthomonadales	S	Predicted integral membrane protein (DUF2189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2189
k59_594910_1	1304865.JAGF01000001_gene2387	1.53e-34	135.0	COG0642@1|root,COG2205@2|Bacteria,2GJKC@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
k59_301527_2	76114.ebA2245	7.41e-131	389.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,2KVQ1@206389|Rhodocyclales	206389|Rhodocyclales	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
k59_829781_1	1454004.AW11_02692	1.6e-126	375.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria,1KQBC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_829781_2	420662.Mpe_A2502	1.36e-36	131.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2VIM1@28216|Betaproteobacteria,1KKR0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Regulator	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_892206_1	1249627.D779_3802	2.4e-33	128.0	COG2214@1|root,COG2981@1|root,COG2214@2|Bacteria,COG2981@2|Bacteria,1MVFT@1224|Proteobacteria,1RMQT@1236|Gammaproteobacteria,1WWYG@135613|Chromatiales	135613|Chromatiales	E	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway	cysZ	-	-	ko:K06203	-	-	-	-	ko00000	-	-	-	DnaJ,EI24
k59_12925_1	190486.XAC3385	8.32e-143	414.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1X3US@135614|Xanthomonadales	135614|Xanthomonadales	NU	Pilus assembly protein	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_477609_1	744980.TRICHSKD4_5548	4.87e-14	72.4	COG0494@1|root,COG0494@2|Bacteria,1MZ5D@1224|Proteobacteria,2UBX9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_477609_2	192952.MM_2952	1.71e-13	70.1	COG2326@1|root,arCOG03575@2157|Archaea,2XV3H@28890|Euryarchaeota,2N9AK@224756|Methanomicrobia	224756|Methanomicrobia	F	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_712604_2	1535422.ND16A_2633	3.43e-49	164.0	2CAXM@1|root,32RSB@2|Bacteria,1N10K@1224|Proteobacteria,1SBHX@1236|Gammaproteobacteria,2Q88F@267889|Colwelliaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
k59_653897_1	391625.PPSIR1_09380	7.39e-82	269.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,2YUJ6@29|Myxococcales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1768536_1	298654.FraEuI1c_0531	3.5e-64	208.0	COG1744@1|root,COG1744@2|Bacteria	2|Bacteria	ET	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp,TAT_signal
k59_70526_1	1121445.ATUZ01000011_gene903	3.57e-08	53.1	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	btrV	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
k59_70526_2	1408254.T458_02450	2.45e-12	66.6	COG1595@1|root,COG1595@2|Bacteria,1V5UR@1239|Firmicutes,4IQ33@91061|Bacilli,2767N@186822|Paenibacillaceae	91061|Bacilli	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_653898_2	686340.Metal_1485	3.89e-55	179.0	COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria,1XEB3@135618|Methylococcales	135618|Methylococcales	E	subfamily IB	-	-	-	-	-	-	-	-	-	-	-	-	HAD
k59_1477281_2	1120950.KB892739_gene3920	5.14e-128	387.0	COG0308@1|root,COG0308@2|Bacteria,2IAPJ@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Peptidase_M1,Peptidase_M6
k59_1066815_2	1125973.JNLC01000001_gene162	5.94e-60	200.0	COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2TT0V@28211|Alphaproteobacteria,3K2TG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Putative serine dehydratase domain	-	-	4.3.1.18	ko:K01753	ko00260,map00260	-	R00221	RC02600	ko00000,ko00001,ko01000	-	-	-	Ala_racemase_N,D-ser_dehydrat
k59_1303422_1	580332.Slit_1728	4.17e-09	57.0	COG0446@1|root,COG0446@2|Bacteria,1QTP3@1224|Proteobacteria,2W9DC@28216|Betaproteobacteria,44WBG@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_829798_1	1123065.ATWL01000008_gene2528	1.46e-10	61.6	COG0366@1|root,COG0366@2|Bacteria,2GJKR@201174|Actinobacteria	201174|Actinobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_829798_2	1120946.AUBF01000004_gene1506	1.76e-12	69.7	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,4D325@85005|Actinomycetales	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.196,3.2.1.68	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02111,R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_1182333_1	1380354.JIAN01000005_gene2188	2.02e-82	246.0	2DK0G@1|root,30823@2|Bacteria,2IJ7K@201174|Actinobacteria	201174|Actinobacteria	S	Rifampin ADP-ribosyl transferase	arr	-	-	ko:K19062	-	-	-	-	ko00000,ko01504	-	-	-	Arr-ms
k59_1182333_2	468556.AQYG01000043_gene286	2.39e-14	71.2	COG0384@1|root,COG0384@2|Bacteria,2GM1W@201174|Actinobacteria,4GA83@85026|Gordoniaceae	201174|Actinobacteria	S	Phenazine biosynthesis-like protein	phzF	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
k59_712619_1	1121013.P873_00940	5.62e-47	166.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1X44W@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the hydrolytic cleavage of a carbon-halogen bond in N-ethylammeline	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_1243236_1	471853.Bcav_2169	3.33e-12	64.7	COG0149@1|root,COG0149@2|Bacteria,2GJXZ@201174|Actinobacteria	201174|Actinobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
k59_1243236_2	1713.JOFV01000015_gene1772	1.11e-86	266.0	COG0126@1|root,COG0126@2|Bacteria,2GJC6@201174|Actinobacteria,4F0MD@85016|Cellulomonadaceae	201174|Actinobacteria	G	Belongs to the phosphoglycerate kinase family	pgk	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_1005446_1	706587.Desti_4441	2.58e-39	140.0	COG0730@1|root,COG0730@2|Bacteria,1NJ47@1224|Proteobacteria,42P2D@68525|delta/epsilon subdivisions,2WMG7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_364903_1	572477.Alvin_0063	1.76e-114	339.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1WW4A@135613|Chromatiales	135613|Chromatiales	I	Belongs to the thiolase family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1243238_1	1124780.ANNU01000013_gene3775	1.05e-54	189.0	COG0668@1|root,COG0668@2|Bacteria,4NHU7@976|Bacteroidetes,47JMR@768503|Cytophagia	976|Bacteroidetes	M	Mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
k59_1418107_1	497321.C664_01980	3.45e-110	357.0	COG4447@1|root,COG4447@2|Bacteria,1NRDC@1224|Proteobacteria,2VM3D@28216|Betaproteobacteria	28216|Betaproteobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
k59_14270_1	463191.SSEG_02541	1.99e-33	125.0	COG0135@1|root,COG0135@2|Bacteria,2IHPP@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
k59_14270_2	795955.AFRW01000116_gene1112	4.64e-45	159.0	COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria,1W89R@1268|Micrococcaceae	201174|Actinobacteria	E	Belongs to the TrpC family	trpC	GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
k59_952154_1	102232.GLO73106DRAFT_00027860	2.22e-08	58.2	COG0845@1|root,COG0845@2|Bacteria,1G2V6@1117|Cyanobacteria	1117|Cyanobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	Biotin_lipoyl_2,HlyD_D23
k59_952154_2	2340.JV46_09140	4.52e-63	214.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J4V8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_952155_1	1121422.AUMW01000006_gene782	6.63e-10	64.7	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia	186801|Clostridia	G	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_364916_1	357808.RoseRS_2711	1.26e-57	196.0	COG0569@1|root,COG2985@1|root,COG0569@2|Bacteria,COG2985@2|Bacteria,2G64U@200795|Chloroflexi,374ZG@32061|Chloroflexia	32061|Chloroflexia	P	YidE YbjL duplication domain protein	-	-	-	ko:K07085	-	-	-	-	ko00000	2.A.81	-	-	Asp-Al_Ex,TrkA_C
k59_1122825_1	2340.JV46_06280	3.35e-24	103.0	COG4942@1|root,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,1RR11@1236|Gammaproteobacteria,1J5VT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	COG0739 Membrane proteins related to metalloendopeptidases	nlpD	GO:0000920,GO:0001896,GO:0005575,GO:0005623,GO:0008150,GO:0008219,GO:0009279,GO:0009987,GO:0012501,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0043085,GO:0044093,GO:0044462,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071944	-	ko:K06194,ko:K12943	-	-	-	-	ko00000	1.A.34.1.2	-	-	LysM,Peptidase_M23
k59_1652926_1	1255043.TVNIR_1950	7.94e-57	188.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1WXDH@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_1652926_2	713587.THITH_10345	1.8e-47	156.0	COG1143@1|root,COG1143@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00338,ko:K02573	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
k59_126374_1	523791.Kkor_0140	3.44e-149	434.0	COG3634@1|root,COG3634@2|Bacteria,1MUKD@1224|Proteobacteria,1RNC7@1236|Gammaproteobacteria,1XI31@135619|Oceanospirillales	135619|Oceanospirillales	O	alkyl hydroperoxide reductase	ahpF	-	-	ko:K03387	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Thioredoxin_3
k59_1005468_1	471853.Bcav_2388	1.93e-28	110.0	COG1404@1|root,COG1404@2|Bacteria,2GMN0@201174|Actinobacteria	201174|Actinobacteria	O	SseB protein N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	SseB
k59_1005468_2	1304865.JAGF01000001_gene3682	2.2e-16	80.1	2E7YB@1|root,332CR@2|Bacteria,2IRTP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Spore_YtfJ
k59_830548_2	1123228.AUIH01000001_gene1225	1.59e-109	325.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1XHU9@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
k59_14320_1	419610.Mext_3922	1.86e-62	214.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,1JRCF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_14320_2	717785.HYPMC_4192	4.43e-10	60.1	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,2U18A@28211|Alphaproteobacteria,3N7I5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
k59_248032_1	1220589.CD32_09970	2.13e-09	58.9	COG1030@1|root,COG1030@2|Bacteria,1V6UR@1239|Firmicutes,4HJIN@91061|Bacilli,3IY9J@400634|Lysinibacillus	91061|Bacilli	-	-	M1-693	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
k59_1478310_1	471853.Bcav_2503	1.12e-73	233.0	COG0575@1|root,COG0575@2|Bacteria,2I7ZA@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
k59_1478310_2	471853.Bcav_2502	1.43e-183	520.0	COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria	201174|Actinobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_1652940_1	765912.Thimo_2538	2.49e-53	179.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1WXB7@135613|Chromatiales	135613|Chromatiales	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_185101_1	1121405.dsmv_1967	1.43e-123	372.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MMTC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.12.1.3,1.6.5.3	ko:K00124,ko:K00335,ko:K05587,ko:K18331	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_14336_1	519989.ECTPHS_00690	8.29e-195	555.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1WXCW@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
k59_595584_1	935839.JAGJ01000008_gene1668	7.28e-94	288.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4F3C9@85017|Promicromonosporaceae	201174|Actinobacteria	P	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_1067801_1	1049564.TevJSym_ap00660	1.11e-136	400.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1J55X@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	iSBO_1134.SBO_3206	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1832552_1	1035308.AQYY01000001_gene3085	8.29e-97	289.0	COG0040@1|root,COG0040@2|Bacteria,1TSVZ@1239|Firmicutes,249AR@186801|Clostridia,26120@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
k59_14343_1	1049564.TevJSym_ak00520	1.24e-145	418.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1J69M@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_14343_2	631362.Thi970DRAFT_01578	4.55e-90	291.0	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,1S08E@1236|Gammaproteobacteria,1WXTS@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_595592_1	935866.JAER01000036_gene3431	6.94e-60	202.0	COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria,4DN64@85009|Propionibacteriales	201174|Actinobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_952226_1	1286106.MPL1_07827	1.78e-05	47.0	COG1399@1|root,COG1399@2|Bacteria,1PGKW@1224|Proteobacteria,1RRK3@1236|Gammaproteobacteria,461EX@72273|Thiotrichales	72273|Thiotrichales	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
k59_952226_2	83406.HDN1F_33270	1e-24	94.0	COG0333@1|root,COG0333@2|Bacteria,1N6RF@1224|Proteobacteria,1SC9G@1236|Gammaproteobacteria,1J6TX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
k59_952226_3	227377.CBU_0492	1.73e-06	50.1	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1JDI0@118969|Legionellales	118969|Legionellales	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_1714813_1	519989.ECTPHS_01379	1.07e-78	246.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1WWFQ@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
k59_899098_1	1120941.AUBL01000057_gene952	1.36e-109	333.0	COG0173@1|root,COG0173@2|Bacteria,2GJHU@201174|Actinobacteria,4D45N@85005|Actinomycetales	201174|Actinobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_1838464_1	1158756.AQXQ01000007_gene265	7.56e-74	230.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,1S2U7@1236|Gammaproteobacteria,1WWN0@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_1657335_1	1122951.ATUE01000012_gene518	5.87e-85	280.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,3NIMH@468|Moraxellaceae	1236|Gammaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1838466_2	1283283.ATXA01000032_gene3364	5.55e-19	84.7	COG5361@1|root,COG5361@2|Bacteria,2GKTA@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_718497_1	1249627.D779_1392	1.95e-20	89.7	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1WVWH@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_959165_1	1249627.D779_0840	5.13e-74	243.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWI3@135613|Chromatiales	135613|Chromatiales	L	PFAM UvrD REP helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_718499_1	247156.NFA_9440	2.63e-26	103.0	COG2405@1|root,COG2405@2|Bacteria,2IPXZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1539642_1	1123367.C666_05030	1.71e-73	231.0	COG0348@1|root,COG0348@2|Bacteria,1MWR5@1224|Proteobacteria,2VJGG@28216|Betaproteobacteria,2KUBY@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S binding domain	-	-	-	ko:K02574	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_5
k59_1773973_1	1211844.CBLM010000078_gene2633	5.03e-32	122.0	COG0685@1|root,COG0685@2|Bacteria,1TQFE@1239|Firmicutes,3VPJQ@526524|Erysipelotrichia	526524|Erysipelotrichia	E	Methylenetetrahydrofolate reductase	metF	-	-	-	-	-	-	-	-	-	-	-	MTHFR
k59_900185_1	713586.KB900536_gene3030	2.52e-17	78.2	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1WY2F@135613|Chromatiales	135613|Chromatiales	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_424455_1	768671.ThimaDRAFT_2288	1.2e-106	331.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1127161_1	1123501.KB902284_gene2190	7.61e-36	139.0	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
k59_1075832_1	457570.Nther_0671	3.34e-53	185.0	COG1032@1|root,COG1032@2|Bacteria,1UYAF@1239|Firmicutes,24D1D@186801|Clostridia	186801|Clostridia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_1839533_1	335543.Sfum_1184	3.83e-37	139.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1PFB9@1224|Proteobacteria,437WC@68525|delta/epsilon subdivisions,2X35Z@28221|Deltaproteobacteria,2MS2F@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_542033_1	1049564.TevJSym_ad00260	1.89e-41	150.0	COG1008@1|root,COG1008@2|Bacteria,1R8V8@1224|Proteobacteria,1RZVG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	overlaps another CDS with the same product name	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1715563_1	525368.HMPREF0591_5248	9.36e-09	63.2	28NJJ@1|root,2ZBKQ@2|Bacteria,2IBUV@201174|Actinobacteria,23AI4@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Prim-Pol
k59_718509_1	593907.Celgi_0903	1.26e-59	199.0	COG3346@1|root,COG3346@2|Bacteria,2GMGB@201174|Actinobacteria,4F180@85016|Cellulomonadaceae	201174|Actinobacteria	S	SURF1 family	-	-	-	-	-	-	-	-	-	-	-	-	SURF1
k59_900197_1	1442599.JAAN01000010_gene315	9.52e-29	115.0	COG2911@1|root,COG2911@2|Bacteria,1N4HK@1224|Proteobacteria,1SAHK@1236|Gammaproteobacteria,1X3U3@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_306980_1	616991.JPOO01000001_gene3807	3.19e-70	232.0	COG0457@1|root,COG0457@2|Bacteria,4NH87@976|Bacteroidetes,1HZMD@117743|Flavobacteriia,23FU8@178469|Arenibacter	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
k59_256298_1	998088.B565_3587	9.14e-75	249.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,1RNRZ@1236|Gammaproteobacteria,1Y3NS@135624|Aeromonadales	135624|Aeromonadales	K	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair	rapA	-	-	ko:K03580	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Helicase_C,RapA_C,SNF2_N
k59_371927_1	1042209.HK44_021255	6.35e-17	82.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,1RPVI@1236|Gammaproteobacteria,1YS2G@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	glcB	GO:0000287,GO:0003674,GO:0003824,GO:0004474,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009436,GO:0009987,GO:0016054,GO:0016740,GO:0016746,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046395,GO:0046487,GO:0046872,GO:0046912,GO:0071704,GO:0072329,GO:1901575	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	iECSF_1327.ECSF_2799,iECW_1372.ECW_m3242,iEKO11_1354.EKO11_0745,iWFL_1372.ECW_m3242	Malate_synthase
k59_371927_2	396588.Tgr7_2033	8.71e-82	263.0	COG4664@1|root,COG4665@1|root,COG4664@2|Bacteria,COG4665@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1WWHM@135613|Chromatiales	135613|Chromatiales	Q	TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
k59_256302_1	240016.ABIZ01000001_gene4120	4.67e-110	340.0	COG0465@1|root,COG0465@2|Bacteria,46SB7@74201|Verrucomicrobia,2ITNZ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
k59_1839556_1	396588.Tgr7_0578	1.91e-175	506.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1WW0Q@135613|Chromatiales	135613|Chromatiales	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_1539661_1	1265503.KB905166_gene674	2.68e-28	117.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,2Q7IA@267889|Colwelliaceae	1236|Gammaproteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_959206_1	177439.DP1202	1.32e-130	388.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,2MHX9@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_959206_2	322710.Avin_46270	1.94e-39	135.0	COG1371@1|root,COG1371@2|Bacteria,1RJU0@1224|Proteobacteria,1S8F6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
k59_900219_1	1049564.TevJSym_bh00130	4.42e-47	162.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1J5XC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_900219_2	765912.Thimo_1116	1.33e-15	74.7	29WEY@1|root,30I0T@2|Bacteria,1RGK1@1224|Proteobacteria,1S5PH@1236|Gammaproteobacteria,1WY8Q@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4381)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4381
k59_78379_1	1089545.KB913037_gene847	6.92e-118	349.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,4E4W8@85010|Pseudonocardiales	201174|Actinobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_483274_1	1385515.N791_12280	5.35e-67	221.0	COG1757@1|root,COG1757@2|Bacteria,1MVDF@1224|Proteobacteria,1RS40@1236|Gammaproteobacteria,1X56I@135614|Xanthomonadales	135614|Xanthomonadales	C	Na+/H+ antiporter family	-	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
k59_1127190_1	367299.JOEE01000005_gene3623	1.37e-113	337.0	COG0448@1|root,COG0448@2|Bacteria,2I2EF@201174|Actinobacteria,4FEM7@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_256326_1	497321.C664_01600	6.29e-41	149.0	28I8W@1|root,2Z8BP@2|Bacteria,1N0SC@1224|Proteobacteria,2VK0J@28216|Betaproteobacteria,2KVDQ@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF2863)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2863
k59_483278_2	1075090.GOAMR_14_00490	1.94e-18	84.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4GDMM@85026|Gordoniaceae	201174|Actinobacteria	E	Zinc-binding dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_22769_1	1131269.AQVV01000030_gene281	4.13e-21	94.4	COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria	2|Bacteria	T	Gaf domain	-	-	4.6.1.1	ko:K01768,ko:K04769	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03000	-	-	-	AAA_35,GAF,GAF_2,Guanylate_cyc,PAS,PAS_4,PAS_8,PAS_9
k59_1485455_1	1453501.JELR01000002_gene1329	2.24e-23	104.0	COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,46DC5@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
k59_371970_1	979556.MTES_3633	8.14e-11	61.2	2EGIC@1|root,33AAH@2|Bacteria,2GRS5@201174|Actinobacteria,4FQ63@85023|Microbacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3099)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3099
k59_371970_2	367299.JOEE01000005_gene3617	2.38e-55	178.0	COG1028@1|root,COG1028@2|Bacteria,2GK6C@201174|Actinobacteria,4FF2A@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1311410_1	227377.CBU_1446	2.49e-21	91.7	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,1S2ET@1236|Gammaproteobacteria,1JDGH@118969|Legionellales	118969|Legionellales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_959243_1	1121405.dsmv_3071	1.18e-73	227.0	COG0834@1|root,COG0834@2|Bacteria,1MWDK@1224|Proteobacteria,42NVT@68525|delta/epsilon subdivisions,2WIRY@28221|Deltaproteobacteria,2MI8X@213118|Desulfobacterales	28221|Deltaproteobacteria	ET	SMART ABC-type transporter, periplasmic subunit family 3, ionotropic glutamate receptor	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_900250_1	485915.Dret_1021	1.12e-38	139.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,42NCJ@68525|delta/epsilon subdivisions,2WMIS@28221|Deltaproteobacteria,2MG31@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_542084_1	367299.JOEE01000008_gene415	2.57e-99	313.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4FE5A@85021|Intrasporangiaceae	201174|Actinobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_1839607_1	717785.HYPMC_2915	1.52e-39	133.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2UC5G@28211|Alphaproteobacteria,3N7A9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_22791_1	1120963.KB894496_gene2642	3.95e-20	90.1	COG2111@1|root,COG2111@2|Bacteria,1QVK4@1224|Proteobacteria,1T54T@1236|Gammaproteobacteria,2Q4I9@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	P	Domain related to MnhB subunit of Na+/H+ antiporter	-	-	-	-	-	-	-	-	-	-	-	-	MnhB
k59_22791_3	1123368.AUIS01000004_gene136	2.93e-32	125.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RYB4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter MnhD subunit	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M,Proton_antipo_N
k59_256356_1	1047013.AQSP01000135_gene1591	1.18e-18	86.7	COG0728@1|root,COG0728@2|Bacteria,2NNX8@2323|unclassified Bacteria	2|Bacteria	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_78428_1	1096546.WYO_0254	3.87e-54	179.0	COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2TTNG@28211|Alphaproteobacteria,1JSF8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	MA20_43565	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1250454_1	637905.SVI_1174	1.94e-37	143.0	COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1T213@1236|Gammaproteobacteria,2Q9WZ@267890|Shewanellaceae	1236|Gammaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	2.7.13.3	ko:K07637	ko01503,ko02020,map01503,map02020	M00444,M00709,M00721,M00723,M00724,M00744	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HATPase_c
k59_900281_1	518766.Rmar_2182	2.04e-08	58.2	COG0558@1|root,COG0558@2|Bacteria,4P65Y@976|Bacteroidetes,1FJHZ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_307054_1	95619.PM1_0203105	4.03e-45	155.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
k59_307054_2	977880.RALTA_A2904	6.15e-59	192.0	COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2VRBQ@28216|Betaproteobacteria,1K3TE@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain	msrQ	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
k59_660004_2	309807.SRU_2249	1.18e-15	78.6	COG1595@1|root,COG1595@2|Bacteria,4NRYN@976|Bacteroidetes	976|Bacteroidetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1485494_1	1123393.KB891317_gene2367	1.6e-116	354.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJI0@28216|Betaproteobacteria,1KSRU@119069|Hydrogenophilales	119069|Hydrogenophilales	P	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_1423403_1	1206777.B195_14565	3.24e-19	92.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1Z59F@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	T	sensor histidine kinase	chpA	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_900294_1	1120985.AUMI01000011_gene520	1.16e-21	95.9	COG1525@1|root,COG1525@2|Bacteria,1VASF@1239|Firmicutes	1239|Firmicutes	L	nuclease	nucI	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	SNase
k59_774675_2	1123065.ATWL01000001_gene444	2.19e-38	139.0	COG0454@1|root,COG0456@2|Bacteria,2II5Y@201174|Actinobacteria	201174|Actinobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1075972_1	335543.Sfum_3077	1.13e-56	183.0	COG0558@1|root,COG0558@2|Bacteria,1N9TT@1224|Proteobacteria,42V2Q@68525|delta/epsilon subdivisions,2WRYY@28221|Deltaproteobacteria,2MSEQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf,GtrA
k59_1250476_1	266835.14024062	5.25e-12	67.8	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TR3X@28211|Alphaproteobacteria,43HZ5@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	of ABC transporters with duplicated ATPase	uup	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD
k59_78464_1	1260251.SPISAL_05575	1.69e-162	495.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1WWGW@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM ATP-dependent helicase HrpA	-	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_256394_1	1380393.JHVP01000005_gene3553	1.99e-80	266.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2I5GH@201174|Actinobacteria,4EX4D@85013|Frankiales	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc
k59_256394_2	1172179.AUKV01000009_gene4379	5.87e-06	48.1	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria	201174|Actinobacteria	OT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,cNMP_binding
k59_1127253_1	1163408.UU9_02838	4.58e-24	95.9	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,1S40D@1236|Gammaproteobacteria,1X50D@135614|Xanthomonadales	135614|Xanthomonadales	S	adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
k59_1127253_2	305700.B447_15856	1.1e-16	82.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2VH64@28216|Betaproteobacteria,2KVFE@206389|Rhodocyclales	206389|Rhodocyclales	H	COG4206 Outer membrane cobalamin receptor protein	-	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	Plug,TonB_dep_Rec
k59_1539738_1	1123253.AUBD01000004_gene1033	9.67e-17	79.7	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1X3YG@135614|Xanthomonadales	135614|Xanthomonadales	T	Fis family transcriptional regulator	fleQ	-	-	ko:K10941	ko02020,ko02025,ko05111,map02020,map02025,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	FleQ,HTH_8,Sigma54_activat
k59_1539738_2	519989.ECTPHS_04733	3.81e-11	68.6	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1T1IJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	ko:K06714,ko:K10943	ko02020,ko05111,map02020,map05111	M00515	-	-	ko00000,ko00001,ko00002,ko02022,ko03000	-	-	-	HTH_8,PAS_8,Sigma54_activat
k59_1715679_1	1381123.AYOD01000035_gene3382	4.3e-49	161.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,43I9I@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	Belongs to the GST superfamily	yfcG	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_C_2,GST_N,GST_N_3
k59_1715679_2	402881.Plav_2312	4.58e-40	136.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria,1JNVJ@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_1598093_1	441769.ABFU01000056_gene872	1.04e-23	102.0	COG3459@1|root,COG3459@2|Bacteria,1TR4V@1239|Firmicutes,4HDDH@91061|Bacilli,1ZDHD@1386|Bacillus	91061|Bacilli	G	Cellobiose phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1598093_2	935845.JADQ01000012_gene2738	3.09e-13	69.3	COG3459@1|root,COG3459@2|Bacteria,1UYFP@1239|Firmicutes,4HTB7@91061|Bacilli,26T3B@186822|Paenibacillaceae	91061|Bacilli	G	Cellobiose phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36
k59_542137_1	1279009.ADICEAN_03034	5.47e-85	276.0	COG1009@1|root,COG1009@2|Bacteria,4NEBM@976|Bacteroidetes,47M8Q@768503|Cytophagia	976|Bacteroidetes	CP	NADH ubiquinone oxidoreductase subunit 5 (Chain L) multisubunit Na H antiporter, MnhA subunit	mrpA	-	1.6.5.3	ko:K00341,ko:K05565	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	DUF4040,Proton_antipo_M,Proton_antipo_N
k59_1658252_1	384765.SIAM614_22462	2.44e-92	280.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria	1224|Proteobacteria	L	Transposase	ISPlu13C	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_483345_1	768671.ThimaDRAFT_4618	6.92e-84	260.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,1WW8H@135613|Chromatiales	135613|Chromatiales	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_959319_1	882.DVU_0967	4.92e-05	44.7	COG0765@1|root,COG0765@2|Bacteria,1MX3E@1224|Proteobacteria,42N9B@68525|delta/epsilon subdivisions,2WIYW@28221|Deltaproteobacteria,2M9VH@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	-	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1,SBP_bac_3
k59_959319_2	1117958.PE143B_0111620	3.21e-71	223.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,1RMX1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	(ABC) transporter	yqiZ	-	3.6.3.21	ko:K02028,ko:K02029	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran,BPD_transp_1
k59_1840565_1	582744.Msip34_2161	2.46e-19	92.4	COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,2VKWX@28216|Betaproteobacteria,2KKSH@206350|Nitrosomonadales	206350|Nitrosomonadales	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_1082830_1	396588.Tgr7_0001	7.29e-152	438.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1WW6C@135613|Chromatiales	135613|Chromatiales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_379144_1	443598.AUFA01000007_gene4579	2.73e-32	122.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2TRQA@28211|Alphaproteobacteria,3JT8T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_1428530_1	658086.HMPREF0994_01131	4.07e-07	57.0	COG0500@1|root,COG2226@2|Bacteria,1TR6N@1239|Firmicutes,2494W@186801|Clostridia	186801|Clostridia	Q	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_605555_1	102125.Xen7305DRAFT_00036230	6.33e-13	73.9	COG2931@1|root,COG2931@2|Bacteria,1G2GC@1117|Cyanobacteria,3VKZ9@52604|Pleurocapsales	1117|Cyanobacteria	Q	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,FG-GAP
k59_723427_1	1095772.CAHH01000030_gene1728	5.13e-18	84.0	COG1200@1|root,COG1200@2|Bacteria,2GKA3@201174|Actinobacteria	201174|Actinobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge,tRNA_anti-codon
k59_723427_2	873449.STRCR_0713	8.29e-12	67.8	COG1131@1|root,COG1131@2|Bacteria,1TP4J@1239|Firmicutes,4HBGH@91061|Bacilli	91061|Bacilli	V	abc transporter atp-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_966353_1	1304865.JAGF01000001_gene1065	5.91e-233	662.0	COG0480@1|root,COG0480@2|Bacteria,2GKRU@201174|Actinobacteria,4F323@85016|Cellulomonadaceae	201174|Actinobacteria	J	elongation factor Tu domain 2 protein	fusA2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1256908_1	84531.JMTZ01000073_gene2118	9.46e-43	158.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1X3CZ@135614|Xanthomonadales	135614|Xanthomonadales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_1256908_2	314278.NB231_15763	7.26e-21	89.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,1WYG6@135613|Chromatiales	135613|Chromatiales	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
k59_1846770_1	62928.azo1877	1.55e-106	317.0	COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,2VJAD@28216|Betaproteobacteria,2KV8P@206389|Rhodocyclales	206389|Rhodocyclales	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rmlB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
k59_263953_1	1322246.BN4_10161	6.23e-65	209.0	COG0492@1|root,COG0492@2|Bacteria,1R82E@1224|Proteobacteria,42PSM@68525|delta/epsilon subdivisions,2WJYX@28221|Deltaproteobacteria,2M8GU@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
k59_488378_1	640081.Dsui_3157	2.47e-87	282.0	28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,2VMEK@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Pfam Fatty acid	cti	-	-	-	-	-	-	-	-	-	-	-	CTI
k59_1846782_1	382464.ABSI01000013_gene1850	1.41e-71	231.0	COG3039@1|root,COG3039@2|Bacteria,46WXW@74201|Verrucomicrobia,2IWQD@203494|Verrucomicrobiae	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1131986_1	1120945.ATUW01000008_gene973	4.78e-50	177.0	COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,4D4GH@85005|Actinomycetales	201174|Actinobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
k59_1663472_1	187272.Mlg_2486	1.02e-06	49.7	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,1RNH2@1236|Gammaproteobacteria,1WWM8@135613|Chromatiales	135613|Chromatiales	IQ	TIGRFAM acetoacetyl-CoA reductase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
k59_1663472_2	395493.BegalDRAFT_2988	2.51e-69	220.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed	yqeF	GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034308,GO:0034309,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046165,GO:0046395,GO:0055114,GO:0071270,GO:0071271,GO:0071704,GO:0072329,GO:1901575,GO:1901576,GO:1901615,GO:1901617	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iSSON_1240.SSON_3004	Thiolase_C,Thiolase_N
k59_546932_1	1226994.AMZB01000082_gene284	3.71e-06	48.1	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1YDCF@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
k59_546932_2	631362.Thi970DRAFT_02140	1.08e-58	189.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,1RNXE@1236|Gammaproteobacteria,1WW3N@135613|Chromatiales	135613|Chromatiales	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
k59_840777_1	987059.RBXJA2T_08385	1.01e-65	222.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,1KIZX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_429617_1	1249627.D779_2440	6.2e-07	53.5	COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,1WVWC@135613|Chromatiales	135613|Chromatiales	K	TIGRFAM RNA polymerase sigma factor RpoS	rpoS	-	-	ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_429617_2	747.DR93_464	8.12e-23	97.8	COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,1RR11@1236|Gammaproteobacteria,1Y752@135625|Pasteurellales	135625|Pasteurellales	M	Outer membrane antigenic lipoprotein B	nlpD	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	LysM,Peptidase_M23
k59_665028_1	523791.Kkor_0209	1.86e-44	164.0	COG0471@1|root,COG0490@1|root,COG0569@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,COG0569@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1XHSW@135619|Oceanospirillales	135619|Oceanospirillales	P	COG0471 Di- and tricarboxylate transporters	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_30065_1	1122963.AUHB01000010_gene1589	1.42e-11	65.9	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,36XPJ@31993|Methylocystaceae	28211|Alphaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_30065_2	1131553.JIBI01000002_gene1864	7.14e-10	59.3	2EB0T@1|root,3351P@2|Bacteria,1NCHM@1224|Proteobacteria,2WBFI@28216|Betaproteobacteria,373DI@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1193522_1	1144888.CM001467_gene1526	1.44e-53	179.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_488391_1	1322246.BN4_20127	1.16e-50	179.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MU2@68525|delta/epsilon subdivisions,2WMYH@28221|Deltaproteobacteria,2MGXV@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1663474_1	338963.Pcar_1232	1.99e-34	141.0	COG1480@1|root,COG1480@2|Bacteria,1NCY5@1224|Proteobacteria,42MI9@68525|delta/epsilon subdivisions,2WJI1@28221|Deltaproteobacteria,43SCT@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	7TM-HD extracellular	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
k59_1131994_1	1385518.N798_17095	1.07e-108	326.0	COG1819@1|root,COG1819@2|Bacteria,2HEXA@201174|Actinobacteria,4FFXB@85021|Intrasporangiaceae	201174|Actinobacteria	CG	UDP-glucoronosyl and UDP-glucosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	UDPGT
k59_379186_1	521719.ATXQ01000003_gene2045	6.41e-24	97.4	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,1RMPD@1236|Gammaproteobacteria,1YF1G@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c45060,iECO26_1355.ECO26_5099,ic_1306.c4947	ThiG
k59_379186_2	1049564.TevJSym_bv00120	8.7e-17	73.9	COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,1SGCU@1236|Gammaproteobacteria,1JBJK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	ThiS family	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
k59_379186_3	1279019.ARQK01000051_gene1407	2.99e-17	82.4	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales	135613|Chromatiales	I	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_30070_1	439235.Dalk_2268	8.15e-58	192.0	COG4191@1|root,COG4191@2|Bacteria,1R682@1224|Proteobacteria,42P91@68525|delta/epsilon subdivisions,2WKQI@28221|Deltaproteobacteria,2MJEK@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9
k59_966392_1	2340.JV46_22090	1.66e-113	337.0	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,1RMGK@1236|Gammaproteobacteria,1J7VM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1428564_1	472759.Nhal_0064	5.8e-67	211.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1WX89@135613|Chromatiales	135613|Chromatiales	C	PFAM cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_1603065_1	1394178.AWOO02000057_gene697	1.45e-32	125.0	COG0584@1|root,COG0584@2|Bacteria,2I8GW@201174|Actinobacteria	201174|Actinobacteria	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_1603065_2	768706.Desor_1833	5.12e-13	74.7	COG1835@1|root,COG1835@2|Bacteria,1V7CG@1239|Firmicutes,24WKR@186801|Clostridia,263B9@186807|Peptococcaceae	186801|Clostridia	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_195404_1	1385519.N801_15730	2.61e-16	72.8	2B3F2@1|root,31W3Z@2|Bacteria,2GWMI@201174|Actinobacteria,4FI3E@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_195404_2	1385519.N801_15735	1.12e-32	121.0	COG1189@1|root,COG1189@2|Bacteria,2GJVT@201174|Actinobacteria,4FGMT@85021|Intrasporangiaceae	201174|Actinobacteria	J	FtsJ-like methyltransferase	tlyA	GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
k59_1193533_1	1499967.BAYZ01000055_gene4849	1.34e-17	79.7	COG2331@1|root,COG2331@2|Bacteria,2NQ36@2323|unclassified Bacteria	2|Bacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
k59_1256961_1	1121933.AUHH01000008_gene1133	7.3e-33	126.0	COG2072@1|root,COG2072@2|Bacteria,2GM3S@201174|Actinobacteria,4DQ11@85009|Propionibacteriales	201174|Actinobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
k59_488411_1	1206732.BAGD01000054_gene1955	7.83e-35	124.0	2EC8S@1|root,33677@2|Bacteria,2GUT2@201174|Actinobacteria,4G3D7@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1779467_1	582899.Hden_2012	5.67e-17	85.9	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2TRKK@28211|Alphaproteobacteria,3N7EE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Mechanosensitive ion channel	kefA	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	DUF3772,MS_channel
k59_1014393_1	1123368.AUIS01000010_gene2370	2.81e-30	114.0	COG4798@1|root,COG4798@2|Bacteria,1QUNP@1224|Proteobacteria,1S3N0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_379991_1	1121405.dsmv_1990	7.54e-36	140.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,42PT5@68525|delta/epsilon subdivisions,2WIPN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NADH-quinone oxidoreductase, chain G	nuoG-2	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_313021_1	945543.VIBR0546_00120	3.07e-51	182.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1XT5Z@135623|Vibrionales	135623|Vibrionales	M	protease	prc	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	BAGE,DUF3340,PDZ,Peptidase_S41
k59_1257630_1	1165841.SULAR_03382	5.36e-25	100.0	COG1266@1|root,COG1266@2|Bacteria,1ND7U@1224|Proteobacteria	1224|Proteobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_1779998_1	471853.Bcav_2427	6.38e-131	382.0	COG2047@1|root,COG2047@2|Bacteria,2GK8I@201174|Actinobacteria	201174|Actinobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
k59_1319486_1	1247963.JPHU01000009_gene2341	1.11e-05	52.8	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,2TRK1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
k59_665569_1	1112217.PPL19_05190	2.63e-52	182.0	COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,1RPEK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Terminase	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_1
k59_30986_1	1037409.BJ6T_21740	1.01e-89	273.0	COG1409@1|root,COG1409@2|Bacteria,1R6R1@1224|Proteobacteria,2U1NR@28211|Alphaproteobacteria,3JSDG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_1429154_1	367299.JOEE01000001_gene2008	1.67e-15	72.4	COG0454@1|root,COG0456@2|Bacteria,2IHG4@201174|Actinobacteria,4FGF4@85021|Intrasporangiaceae	201174|Actinobacteria	K	N-acetyltransferase GCN5	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1429154_2	367299.JOEE01000001_gene2009	1.49e-107	313.0	COG0569@1|root,COG0569@2|Bacteria,2IA09@201174|Actinobacteria,4FECF@85021|Intrasporangiaceae	201174|Actinobacteria	P	Potassium	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_606185_1	583355.Caka_2045	4.1e-107	348.0	COG0771@1|root,COG2911@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	murD	-	3.4.21.10,6.3.2.13,6.3.2.9	ko:K01317,ko:K01925,ko:K01928,ko:K01932	ko00300,ko00471,ko00550,ko01100,map00300,map00471,map00550,map01100	-	R02783,R02788	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01002,ko01011,ko04131	-	-	-	DUF1727,Mur_ligase_C,Mur_ligase_M
k59_430182_1	440512.C211_05725	7.51e-51	184.0	28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,1RN0X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	isomerase	cti	-	-	-	-	-	-	-	-	-	-	-	CTI
k59_967261_1	1144325.PMI22_01183	8.01e-45	161.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1S3FP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_86488_1	768671.ThimaDRAFT_3148	4.04e-90	296.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1WXPZ@135613|Chromatiales	135613|Chromatiales	L	DEAD DEAH box	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
k59_380021_1	32049.SYNPCC7002_A0141	3.49e-61	210.0	COG0542@1|root,COG0542@2|Bacteria,1G0ZH@1117|Cyanobacteria,1GYXV@1129|Synechococcus	1117|Cyanobacteria	O	Belongs to the ClpA ClpB family	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
k59_1014412_1	1123065.ATWL01000002_gene1395	2.04e-98	290.0	COG0193@1|root,COG0193@2|Bacteria,2GKCV@201174|Actinobacteria	201174|Actinobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
k59_908317_1	367299.JOEE01000004_gene1419	1.82e-16	84.0	COG1752@1|root,COG1752@2|Bacteria,2IAR4@201174|Actinobacteria,4FIT1@85021|Intrasporangiaceae	201174|Actinobacteria	S	Esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1664072_1	592029.DDD_1503	5.15e-45	169.0	COG0574@1|root,COG0574@2|Bacteria,4NH4R@976|Bacteroidetes,1HWKY@117743|Flavobacteriia,3HK25@363408|Nonlabens	976|Bacteroidetes	G	Pyruvate phosphate dikinase	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_1429168_1	1304865.JAGF01000001_gene2476	7.23e-133	404.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,2GJ0A@201174|Actinobacteria,4F0FS@85016|Cellulomonadaceae	201174|Actinobacteria	E	TIGRFAM glutamate synthase, NADH NADPH, small subunit	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,NAD_binding_1,Pyr_redox_2
k59_547511_1	670307.HYPDE_36393	2.59e-71	235.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,3N69N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Methylmalonyl-CoA mutase	mutB	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
k59_489004_1	446466.Cfla_3381	3.05e-101	303.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4F0YJ@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM Transketolase central region	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_264885_1	1267005.KB911256_gene1832	2.6e-130	380.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TRAH@28211|Alphaproteobacteria,3N6GF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_1603622_1	1198232.CYCME_0916	9.49e-23	102.0	COG3144@1|root,COG3144@2|Bacteria,1N7XT@1224|Proteobacteria,1SCA6@1236|Gammaproteobacteria,461BA@72273|Thiotrichales	72273|Thiotrichales	N	Flagellar hook-length control protein	-	-	-	ko:K02414	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_hook
k59_1603622_2	2340.JV46_20560	5.66e-21	91.3	COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,1J51N@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane	lapB	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008653,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1903509	-	ko:K19804	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_19,TPR_7,TPR_8
k59_1664077_1	1265505.ATUG01000001_gene3624	4.79e-39	146.0	COG0642@1|root,COG2205@2|Bacteria,1QUJ7@1224|Proteobacteria,43BJF@68525|delta/epsilon subdivisions,2WU4G@28221|Deltaproteobacteria,2MMQM@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_1014424_1	1121939.L861_07930	5.68e-50	178.0	COG1234@1|root,COG1234@2|Bacteria,1PPRD@1224|Proteobacteria,1RRV8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Beta-lactamase superfamily domain	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	CLP1_P,Lactamase_B,Lactamase_B_2
k59_1257673_1	1382304.JNIL01000001_gene1752	1.93e-73	234.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,4HA2Y@91061|Bacilli,27912@186823|Alicyclobacillaceae	91061|Bacilli	E	Catalyzes the interconversion of ornithine to glutamate semialdehyde	rocD	GO:0003674,GO:0003824,GO:0004587,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	iYO844.BSU40340	Aminotran_3
k59_779562_1	153721.MYP_4245	7.39e-50	179.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,47KIX@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolase family 3 C-terminal domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_1721528_1	713586.KB900536_gene179	1.32e-140	413.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1WWWR@135613|Chromatiales	135613|Chromatiales	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_1721528_2	519989.ECTPHS_08343	8.16e-37	131.0	COG3086@1|root,COG3086@2|Bacteria,1N6QS@1224|Proteobacteria,1SCTM@1236|Gammaproteobacteria,1WYRU@135613|Chromatiales	135613|Chromatiales	T	PFAM Positive regulator of sigma(E), RseC MucC	-	-	-	ko:K03803	-	-	-	-	ko00000,ko03021	-	-	-	RseC_MucC
k59_1721528_3	105559.Nwat_0670	6.12e-11	63.9	COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,1RNF3@1236|Gammaproteobacteria,1WWVY@135613|Chromatiales	135613|Chromatiales	T	PFAM MucB RseB	-	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	MucB_RseB,MucB_RseB_C
k59_1369558_1	765912.Thimo_0009	9.74e-65	214.0	COG3436@1|root,COG3436@2|Bacteria,1MYAC@1224|Proteobacteria,1T2KH@1236|Gammaproteobacteria,1X2VE@135613|Chromatiales	135613|Chromatiales	L	IS66 C-terminal element	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C
k59_1603637_1	113395.AXAI01000001_gene3301	4.65e-56	189.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,2TS37@28211|Alphaproteobacteria,3JTXY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
k59_1014432_1	1187851.A33M_4208	1.52e-99	304.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,3FCY5@34008|Rhodovulum	28211|Alphaproteobacteria	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2
k59_1083619_2	1123368.AUIS01000007_gene2819	0.000267	45.8	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,2NCEM@225057|Acidithiobacillales	1236|Gammaproteobacteria	BQ	Histone deacetylase domain	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
k59_547535_1	522373.Smlt1688	3.98e-13	67.4	2EFX9@1|root,339PI@2|Bacteria,1NI0D@1224|Proteobacteria,1SGKH@1236|Gammaproteobacteria,1X8GR@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_547535_2	314285.KT71_17006	5.57e-29	112.0	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,1J545@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex	ccoP	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	iJN746.PP_4253	Cytochrome_CBB3,FixP_N
k59_1603642_1	298655.KI912266_gene2218	2.6e-105	322.0	COG4992@1|root,COG4992@2|Bacteria,2GUAV@201174|Actinobacteria,4ETTW@85013|Frankiales	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	patA	-	2.6.1.82	ko:K09251	ko00330,ko01100,map00330,map01100	-	R01155	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_1607099_1	1163408.UU9_14435	8.69e-35	130.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,1RP0M@1236|Gammaproteobacteria,1X6N1@135614|Xanthomonadales	135614|Xanthomonadales	G	D-galactarate dehydratase / Altronate hydrolase, C terminus	garD	-	4.2.1.42,4.2.1.7	ko:K01685,ko:K01708	ko00040,ko00053,ko01100,map00040,map00053,map01100	M00631	R01540,R05608	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
k59_1607099_2	1096930.L284_21980	2.23e-55	186.0	COG1904@1|root,COG1904@2|Bacteria,1MVRI@1224|Proteobacteria,2TS93@28211|Alphaproteobacteria,2JZWP@204457|Sphingomonadales	204457|Sphingomonadales	G	glucuronate isomerase	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
k59_914705_1	768671.ThimaDRAFT_0349	3.1e-98	304.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1WW89@135613|Chromatiales	135613|Chromatiales	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
k59_434514_2	367299.JOEE01000008_gene457	8.55e-47	158.0	COG2326@1|root,COG2326@2|Bacteria,2GKRN@201174|Actinobacteria,4FFBT@85021|Intrasporangiaceae	201174|Actinobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_1607587_1	565045.NOR51B_705	1.02e-37	139.0	COG1196@1|root,COG1196@2|Bacteria,1R4BS@1224|Proteobacteria,1S13B@1236|Gammaproteobacteria,1J7UD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	von Willebrand factor (VWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_915698_1	446466.Cfla_2312	2.63e-119	352.0	COG0240@1|root,COG0240@2|Bacteria,2GJSD@201174|Actinobacteria,4F1Q8@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM NAD-dependent glycerol-3-phosphate dehydrogenase domain protein	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_1088970_1	177437.HRM2_17430	1.37e-125	372.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,42M9E@68525|delta/epsilon subdivisions,2WJ3F@28221|Deltaproteobacteria,2MI7I@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_271757_2	485913.Krac_1837	3.07e-15	77.4	COG0454@1|root,COG0456@2|Bacteria,2G8UQ@200795|Chloroflexi	200795|Chloroflexi	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1373536_2	1043493.BBLU01000017_gene1432	3.98e-47	157.0	COG2764@1|root,COG2764@2|Bacteria	2|Bacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt,AHSA1,Glyoxalase
k59_1263071_1	172088.AUGA01000021_gene5169	3.52e-111	329.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria,3JSM0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_1783894_1	929558.SMGD1_0695	5.58e-19	95.1	COG2202@1|root,COG2203@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2YTKD@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	Four helix bundle sensory module for signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,HATPase_c,PAS_9
k59_93924_1	28072.Nos7524_3474	8.08e-80	248.0	COG2519@1|root,COG2519@2|Bacteria,1GQ0A@1117|Cyanobacteria,1HSUX@1161|Nostocales	1117|Cyanobacteria	J	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_1088974_1	1452535.JARD01000007_gene1847	1.99e-112	343.0	COG0515@1|root,COG0515@2|Bacteria,2GIW5@201174|Actinobacteria,4FKGW@85023|Microbacteriaceae	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_1136574_1	1429916.X566_06230	2.38e-84	252.0	COG1247@1|root,COG1247@2|Bacteria,1RDNE@1224|Proteobacteria,2U9BP@28211|Alphaproteobacteria,3JVC4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_4
k59_1326967_1	565045.NOR51B_123	7.29e-06	47.0	COG0818@1|root,COG0818@2|Bacteria,1MZ3Q@1224|Proteobacteria,1S92I@1236|Gammaproteobacteria,1J6NZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Recycling of diacylglycerol produced during the turnover of membrane phospholipid	dgkA	-	2.7.1.107	ko:K00901	ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_prokar
k59_1326967_2	1122603.ATVI01000005_gene3075	9.93e-29	112.0	COG0583@1|root,COG0583@2|Bacteria,1MXRP@1224|Proteobacteria,1RQP1@1236|Gammaproteobacteria,1XCVC@135614|Xanthomonadales	135614|Xanthomonadales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1668496_1	670307.HYPDE_41543	2.12e-55	186.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TVFA@28211|Alphaproteobacteria,3N6UY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Transporter associated domain	tlyC	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
k59_1668496_2	1211115.ALIQ01000207_gene4753	1.46e-10	61.6	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2TQRC@28211|Alphaproteobacteria,3N9YI@45404|Beijerinckiaceae	28211|Alphaproteobacteria	M	Carbon-nitrogen hydrolase	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_93931_2	356851.JOAN01000014_gene1992	6.37e-68	232.0	2EXNC@1|root,33QY3@2|Bacteria,2ITB7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_387428_1	697282.Mettu_3445	1.08e-133	392.0	COG3185@1|root,COG3185@2|Bacteria,1R5AJ@1224|Proteobacteria,1RY8F@1236|Gammaproteobacteria,1XG36@135618|Methylococcales	135618|Methylococcales	E	4-Hydroxyphenylpyruvate dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_387428_2	596152.DesU5LDRAFT_3085	9.21e-10	55.8	COG0296@1|root,COG0296@2|Bacteria,1N8WX@1224|Proteobacteria,42VNQ@68525|delta/epsilon subdivisions,2WQ7J@28221|Deltaproteobacteria,2MC6I@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Glycoside hydrolase, family 13	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,CBM_48
k59_1497549_1	1217718.ALOU01000130_gene3911	1.44e-76	233.0	COG0242@1|root,COG0242@2|Bacteria,1R9XK@1224|Proteobacteria,2VQ0U@28216|Betaproteobacteria,1K4G3@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def2	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_1497549_2	1198452.Jab_2c11820	5.69e-09	56.6	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2VI2G@28216|Betaproteobacteria,472BY@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_93940_2	443144.GM21_0444	1.13e-54	177.0	COG0848@1|root,COG0848@2|Bacteria,1RENY@1224|Proteobacteria,42X3K@68525|delta/epsilon subdivisions,2WT0T@28221|Deltaproteobacteria,43V5B@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Biopolymer transport protein ExbD/TolR	aglS	-	-	-	-	-	-	-	-	-	-	-	ExbD
k59_93940_3	1232410.KI421425_gene1543	1.96e-31	122.0	COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,42XJ0@68525|delta/epsilon subdivisions,2WT3A@28221|Deltaproteobacteria,43SUP@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
k59_783282_1	247634.GPB2148_498	4.74e-39	150.0	COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,1S52W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C
k59_141563_1	1232437.KL662026_gene985	3.02e-41	140.0	COG0589@1|root,COG0589@2|Bacteria,1N5SY@1224|Proteobacteria,42UUI@68525|delta/epsilon subdivisions,2WQFX@28221|Deltaproteobacteria,2MM5G@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_669801_1	1123023.JIAI01000005_gene818	2.15e-84	266.0	COG0033@1|root,COG0033@2|Bacteria,2H1PI@201174|Actinobacteria,4E857@85010|Pseudonocardiales	201174|Actinobacteria	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_38431_1	985665.HPL003_06625	4.11e-51	173.0	COG2040@1|root,COG2040@2|Bacteria,1UHQ5@1239|Firmicutes,4HAS6@91061|Bacilli,26TIZ@186822|Paenibacillaceae	91061|Bacilli	E	Homocysteine S-methyltransferase	mmuM	-	2.1.1.10	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	-	R00650	RC00003,RC00035	ko00000,ko00001,ko01000	-	-	-	S-methyl_trans
k59_610599_1	96561.Dole_0504	1.58e-59	188.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,42SD2@68525|delta/epsilon subdivisions,2WP7H@28221|Deltaproteobacteria,2MKBM@213118|Desulfobacterales	28221|Deltaproteobacteria	GT	PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	ptsN	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
k59_1783917_1	1122134.KB893650_gene1005	1.41e-21	98.6	COG3768@1|root,COG3768@2|Bacteria,1MU8S@1224|Proteobacteria,1RND9@1236|Gammaproteobacteria,1XKHP@135619|Oceanospirillales	135619|Oceanospirillales	S	Domain of unknown function (DUF697)	-	-	-	ko:K08990	-	-	-	-	ko00000	-	-	-	DUF697
k59_1783917_2	543728.Vapar_2102	6.48e-22	92.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VHYN@28216|Betaproteobacteria,4AAKJ@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_610613_1	1123073.KB899242_gene1206	1.42e-84	266.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1X3PI@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1549511_1	479435.Kfla_5976	7.26e-65	209.0	COG0631@1|root,COG4307@1|root,COG0631@2|Bacteria,COG4307@2|Bacteria,2GKDM@201174|Actinobacteria,4DN5I@85009|Propionibacteriales	201174|Actinobacteria	T	Serine/threonine phosphatases, family 2C, catalytic domain	prpB10	-	-	-	-	-	-	-	-	-	-	-	DZR,PP2C_2
k59_1549511_2	935839.JAGJ01000026_gene3640	1.57e-08	54.7	COG2304@1|root,COG2304@2|Bacteria,2GMWM@201174|Actinobacteria,4F5AS@85017|Promicromonosporaceae	201174|Actinobacteria	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2,VWA_3
k59_1783925_1	1121481.AUAS01000012_gene269	1.71e-09	58.9	COG0716@1|root,COG0716@2|Bacteria,4NHTB@976|Bacteroidetes,47PXR@768503|Cytophagia	976|Bacteroidetes	C	Dialkylrecorsinol condensing enzyme DarA	darA	-	-	-	-	-	-	-	-	-	-	-	-
k59_1783925_2	471854.Dfer_5797	3.13e-48	164.0	COG0332@1|root,COG0332@2|Bacteria,4NE5Q@976|Bacteroidetes,47KWN@768503|Cytophagia	976|Bacteroidetes	I	PFAM 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III	darB	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III_C,Thiolase_N,ketoacyl-synt
k59_93987_1	1049564.TevJSym_bq00070	8.08e-73	239.0	COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1J4YP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB
k59_1855358_1	933262.AXAM01000052_gene2006	4.53e-82	246.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria,2MHKK@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_271842_1	335543.Sfum_2794	1.01e-81	253.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,2MQ4Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	ferredoxin oxidoreductase alpha subunit	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_38482_1	1176165.CAJD01000011_gene588	4.02e-17	83.2	COG2962@1|root,COG2962@2|Bacteria,2GKCP@201174|Actinobacteria,4F8XK@85019|Brevibacteriaceae	201174|Actinobacteria	S	EamA-like transporter family	rarD	-	-	ko:K05786	-	-	-	-	ko00000,ko02000	2.A.7.7	-	-	EamA
k59_38482_2	991905.SL003B_4177	2.47e-12	67.0	COG2223@1|root,COG2223@2|Bacteria,1QVKP@1224|Proteobacteria,2TRVV@28211|Alphaproteobacteria,4BR8Y@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_915805_1	1123253.AUBD01000008_gene560	8.48e-57	202.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1X4J8@135614|Xanthomonadales	135614|Xanthomonadales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1263138_1	1379281.AVAG01000016_gene969	2.84e-35	126.0	COG1014@1|root,COG1014@2|Bacteria,1N12F@1224|Proteobacteria,42NN1@68525|delta/epsilon subdivisions,2WQFN@28221|Deltaproteobacteria,2M92T@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,POR
k59_1263138_2	335543.Sfum_2793	9.28e-48	154.0	COG1144@1|root,COG1144@2|Bacteria,1N99V@1224|Proteobacteria,42V8C@68525|delta/epsilon subdivisions,2WRCP@28221|Deltaproteobacteria,2MS61@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
k59_845813_1	1461580.CCAS010000051_gene3609	6.23e-09	62.8	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,4HBFZ@91061|Bacilli,1ZBP3@1386|Bacillus	91061|Bacilli	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1783941_1	1415756.JQMY01000001_gene2964	2.62e-15	78.2	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria,2PDJX@252301|Oceanicola	28211|Alphaproteobacteria	L	UvrD-like helicase C-terminal domain	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1783941_2	1122135.KB893146_gene1583	1.33e-22	95.9	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,2TTP3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
k59_1198655_1	316056.RPC_1671	1.25e-79	251.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria,3JS92@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Amidase	MA20_16525	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_271851_1	469610.HMPREF0189_01345	5.9e-74	234.0	COG0492@1|root,COG0492@2|Bacteria,1MW14@1224|Proteobacteria,2VGZS@28216|Betaproteobacteria,1KJ6X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Ferredoxin--NADP reductase	trxB2	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
k59_141613_1	1120970.AUBZ01000008_gene2461	1.95e-46	152.0	COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,1S62I@1236|Gammaproteobacteria,467E8@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Belongs to the UPF0145 family	ybjQ	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
k59_1607658_1	76636.JOEC01000002_gene2769	1.1e-25	106.0	COG1877@1|root,COG1877@2|Bacteria,2GMKW@201174|Actinobacteria,4FNV7@85023|Microbacteriaceae	201174|Actinobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
k59_387543_1	1187851.A33M_4207	9.25e-12	64.3	COG0543@1|root,COG0543@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	gltA	-	1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14	ko:K00266,ko:K00528,ko:K02823	ko00240,ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248,R10159	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,Fer4_20,NAD_binding_1,Pyr_redox_2
k59_1018228_1	519989.ECTPHS_03769	1.52e-62	196.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1WVVN@135613|Chromatiales	135613|Chromatiales	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_1018228_2	1196322.A370_00134	3.43e-07	52.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,36ERC@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
k59_1373614_2	1206732.BAGD01000068_gene2664	1.39e-65	222.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4FU7Y@85025|Nocardiaceae	201174|Actinobacteria	P	PFAM E1-E2 ATPase-associated domain protein, Haloacid dehalogenase domain protein hydrolase, cation transporting ATPase domain protein	ctpF	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.8	ko:K01537,ko:K12953	-	-	-	-	ko00000,ko01000	3.A.3,3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_387557_1	247634.GPB2148_2793	3.24e-29	115.0	COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,1RXV1@1236|Gammaproteobacteria,1J9T6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	COG0534 Na -driven multidrug efflux pump	-	-	-	-	-	-	-	-	-	-	-	-	MatE
k59_387557_2	566466.NOR53_117	3.58e-06	48.5	COG1309@1|root,COG1309@2|Bacteria,1R7F8@1224|Proteobacteria,1RP07@1236|Gammaproteobacteria,1J95M@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1549548_1	1047013.AQSP01000099_gene1500	1.01e-74	236.0	COG0151@1|root,COG0151@2|Bacteria,2NP0B@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the GARS family	purD	-	6.3.2.6,6.3.4.13,6.3.5.3	ko:K01945,ko:K01952,ko:K13713	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04463,R04591	RC00010,RC00064,RC00090,RC00162,RC00166,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS05245,iYO844.BSU06530	GARS_A,GARS_C,GARS_N
k59_200185_1	316279.Syncc9902_1943	2.63e-08	54.7	COG3001@1|root,COG3001@2|Bacteria,1G040@1117|Cyanobacteria,1GZY8@1129|Synechococcus	1117|Cyanobacteria	G	COG3001 Fructosamine-3-kinase	-	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237	-	-	-	-	-	-	-	-	-	-	Fructosamin_kin
k59_200185_2	1562701.BBOF01000061_gene1657	1.36e-41	141.0	COG2940@1|root,COG2940@2|Bacteria,1MWFB@1224|Proteobacteria,2VR5U@28216|Betaproteobacteria,1K2B1@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Nuclear protein SET	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
k59_387566_1	391615.ABSJ01000042_gene2213	6.19e-62	206.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,1J4I7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
k59_387566_2	1082705.JIBP01000020_gene1653	1.36e-12	68.6	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0050570,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	iECO111_1330.ECO111_0056	PdxA
k59_1327130_1	1121405.dsmv_0564	1.37e-85	283.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MXBU@1224|Proteobacteria,42M59@68525|delta/epsilon subdivisions,2WIUK@28221|Deltaproteobacteria,2MICN@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Pyruvate phosphate dikinase, PEP	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_783343_1	1158165.KB898874_gene1801	2.86e-70	229.0	COG0277@1|root,COG0277@2|Bacteria,1MV1Q@1224|Proteobacteria,1RSC3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	FAD binding domain	-	-	1.3.1.72	ko:K09828	ko00100,ko01100,ko01110,map00100,map01100,map01110	M00101	R01457,R03689,R05703,R07488,R07493,R07498,R07499,R07507,R11096	RC00522,RC01887,RC02419	ko00000,ko00001,ko00002,ko01000	-	-	-	ALO,Acetyltransf_1,FAD_binding_4,Methyltransf_11
k59_669883_1	1049564.TevJSym_an00600	3.91e-57	188.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1J543@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_1668588_1	177437.HRM2_26100	8.8e-09	63.2	COG0515@1|root,COG0664@1|root,COG0515@2|Bacteria,COG0664@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2MHTH@213118|Desulfobacterales	28221|Deltaproteobacteria	KLT	PFAM Protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE2,Pkinase,cNMP_binding
k59_141646_1	1449347.JQLN01000005_gene4005	1.14e-70	238.0	COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,2M0FQ@2063|Kitasatospora	201174|Actinobacteria	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	nuoG	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_387598_1	1382359.JIAL01000001_gene1834	1.59e-33	127.0	COG2234@1|root,COG2234@2|Bacteria,3Y406@57723|Acidobacteria,2JIRZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
k59_317651_1	446466.Cfla_1534	1.5e-134	406.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,4F0ZC@85016|Cellulomonadaceae	201174|Actinobacteria	D	Ftsk_gamma	ftsK	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1607691_1	1049564.TevJSym_ar00210	3.64e-46	159.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,1RPBT@1236|Gammaproteobacteria,1J4X2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Nucleoside H+ symporter	hcaT	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
k59_1607691_2	270374.MELB17_14041	1.25e-35	130.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,46517@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iE2348C_1286.E2348C_2469,iEC55989_1330.EC55989_2573,iECO103_1326.ECO103_2794,iECO111_1330.ECO111_3077,iECO26_1355.ECO26_3317,iECSE_1348.ECSE_2638,iECW_1372.ECW_m2518,iEKO11_1354.EKO11_1436,iSSON_1240.SSON_2387,iUMNK88_1353.UMNK88_2882,iWFL_1372.ECW_m2518	Chorismate_synt
k59_141649_1	1304865.JAGF01000001_gene2107	4.02e-157	472.0	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,4F0TJ@85016|Cellulomonadaceae	201174|Actinobacteria	S	Uncharacterised protein family (UPF0182)	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_783355_1	765911.Thivi_2664	4.15e-97	298.0	COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria,1SHHY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
k59_1497646_1	1110697.NCAST_18_01400	6.72e-31	125.0	COG0532@1|root,COG5473@1|root,COG0532@2|Bacteria,COG5473@2|Bacteria,2GN5K@201174|Actinobacteria,4FWY1@85025|Nocardiaceae	201174|Actinobacteria	J	Zn-ribbon protein possibly nucleic acid-binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_915914_1	1121445.ATUZ01000013_gene1049	1.01e-49	167.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,42R4H@68525|delta/epsilon subdivisions,2WNAD@28221|Deltaproteobacteria,2MB44@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
k59_610686_1	292415.Tbd_0868	3.33e-49	180.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJI0@28216|Betaproteobacteria	28216|Betaproteobacteria	P	von Willebrand factor (vWF) type A domain	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA_2
k59_493416_1	1304865.JAGF01000001_gene3093	2.12e-138	411.0	COG0296@1|root,COG0296@2|Bacteria,2GMIS@201174|Actinobacteria,4F2CG@85016|Cellulomonadaceae	201174|Actinobacteria	G	SMART alpha amylase catalytic sub domain	treZ	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0033942,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0071704,GO:1901575,GO:1901576	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
k59_669893_1	1121952.ATXT01000013_gene2262	1.3e-50	163.0	2AYVP@1|root,31R17@2|Bacteria,2HT6Y@201174|Actinobacteria,4FS5A@85023|Microbacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_669893_2	1121952.ATXT01000013_gene2261	7.16e-116	337.0	COG2442@1|root,COG2442@2|Bacteria,2IQVM@201174|Actinobacteria,4FRFM@85023|Microbacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
k59_974982_3	1249627.D779_1266	3.04e-23	91.7	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria,1WYKM@135613|Chromatiales	135613|Chromatiales	S	RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_734433_2	1380354.JIAN01000005_gene1271	2.02e-33	129.0	COG0392@1|root,COG0392@2|Bacteria,2GMAV@201174|Actinobacteria,4F0KN@85016|Cellulomonadaceae	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
k59_1269431_1	439496.RBY4I_1862	1.15e-101	311.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TXAW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_499170_2	717231.Flexsi_0321	3.09e-43	145.0	COG2905@1|root,COG2905@2|Bacteria,2GGGX@200930|Deferribacteres	200930|Deferribacteres	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_1674369_2	1267534.KB906760_gene1554	6.48e-22	89.4	2DD3Z@1|root,2ZGDH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1439432_1	590998.Celf_3803	4.47e-50	176.0	COG1192@1|root,COG1192@2|Bacteria,2GMU7@201174|Actinobacteria,4F322@85016|Cellulomonadaceae	201174|Actinobacteria	D	Anion-transporting ATPase	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_1503814_1	290398.Csal_1440	6.17e-11	63.5	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1XK08@135619|Oceanospirillales	135619|Oceanospirillales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_1503814_2	402881.Plav_0175	7.87e-40	147.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,1JN93@119043|Rhodobiaceae	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_279099_1	999611.KI421504_gene291	7.36e-103	306.0	COG4175@1|root,COG4175@2|Bacteria,1MU86@1224|Proteobacteria,2TS8Y@28211|Alphaproteobacteria,2824Y@191028|Leisingera	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.32	ko:K02000	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	-	ABC_tran
k59_397419_1	880073.Calab_3175	7.39e-73	229.0	COG1064@1|root,COG1064@2|Bacteria,2NP06@2323|unclassified Bacteria	2|Bacteria	S	Alcohol dehydrogenase GroES-like domain	adhA	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1337157_1	1150398.JIBJ01000005_gene3208	2.13e-25	105.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,1W85G@1268|Micrococcaceae	201174|Actinobacteria	M	Exporter of polyketide	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
k59_1337157_2	196162.Noca_2559	1.14e-52	176.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4DPD1@85009|Propionibacteriales	201174|Actinobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_1141532_1	1158292.JPOE01000002_gene3438	1.33e-42	150.0	COG3005@1|root,COG3005@2|Bacteria,1MV9J@1224|Proteobacteria,2WFG5@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c3	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
k59_1439452_1	933262.AXAM01000016_gene158	2.07e-75	233.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,42P8R@68525|delta/epsilon subdivisions,2WKIR@28221|Deltaproteobacteria,2MIUI@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_4,tRNA_m1G_MT
k59_1337181_1	1089455.MOPEL_073_00890	2.22e-138	400.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4F65V@85018|Dermatophilaceae	201174|Actinobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	degT	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
k59_616365_1	557598.LHK_01411	1.86e-20	94.7	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2VI2G@28216|Betaproteobacteria,2KPT8@206351|Neisseriales	206351|Neisseriales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	DUF294,GlnD_UR_UTase,HD,NTP_transf_2
k59_46133_2	395493.BegalDRAFT_2930	1.34e-73	227.0	COG0235@1|root,COG0235@2|Bacteria,1QAVF@1224|Proteobacteria,1RW3I@1236|Gammaproteobacteria,4628Z@72273|Thiotrichales	72273|Thiotrichales	G	PFAM Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
k59_1379402_1	1123400.KB904747_gene554	1.2e-67	212.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,1RRP3@1236|Gammaproteobacteria,460FG@72273|Thiotrichales	72273|Thiotrichales	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_1095162_1	335543.Sfum_0821	2.62e-46	170.0	COG1148@1|root,COG2204@1|root,COG1148@2|Bacteria,COG2204@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FAD_oxidored,Fer4,Fer4_7,NAD_binding_8,Pyr_redox_2,Response_reg
k59_675851_1	631362.Thi970DRAFT_01391	2.25e-75	233.0	COG0457@1|root,COG0457@2|Bacteria,1R85G@1224|Proteobacteria,1S0MD@1236|Gammaproteobacteria,1WXM8@135613|Chromatiales	135613|Chromatiales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_279126_1	864051.BurJ1DRAFT_0396	4.01e-32	117.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2VR6I@28216|Betaproteobacteria,1KKYA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
k59_279126_2	880074.BARVI_06575	3.05e-20	84.7	COG1970@1|root,COG1970@2|Bacteria,4NQ49@976|Bacteroidetes,2FT2E@200643|Bacteroidia,22Y4Y@171551|Porphyromonadaceae	976|Bacteroidetes	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
k59_1337186_1	105559.Nwat_2902	2.89e-243	684.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1WXKA@135613|Chromatiales	135613|Chromatiales	G	PFAM Alpha amylase, catalytic	-	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_925880_1	1265313.HRUBRA_00929	5.24e-51	176.0	COG1196@1|root,COG1196@2|Bacteria,1R4BS@1224|Proteobacteria,1S13B@1236|Gammaproteobacteria,1J7UD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	von Willebrand factor (VWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_734469_1	1122927.KB895414_gene5126	6.89e-60	196.0	COG0604@1|root,COG0604@2|Bacteria,1TQ0M@1239|Firmicutes,4HA8M@91061|Bacilli,26QXS@186822|Paenibacillaceae	91061|Bacilli	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
k59_557755_1	426114.THI_0005	6.69e-20	89.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,1KJAE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Formate dehydrogenase, alpha subunit	fdhA1	-	1.17.1.9,1.17.99.7	ko:K00123,ko:K22015	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_557755_2	535289.Dtpsy_2798	1.74e-63	211.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VIMM@28216|Betaproteobacteria,4AB8V@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit	fdwB	-	1.17.1.9	ko:K00122	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_1788847_2	742767.HMPREF9456_01214	3.13e-13	71.6	COG1595@1|root,COG1595@2|Bacteria,4NSVA@976|Bacteroidetes,2FMT6@200643|Bacteroidia,22Y4K@171551|Porphyromonadaceae	976|Bacteroidetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1022993_1	1449058.JQKT01000009_gene122	4.28e-61	199.0	arCOG12964@1|root,2Z7HP@2|Bacteria	2|Bacteria	S	Tocopherol cyclase	-	-	5.5.1.24	ko:K09834	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00112	R07502,R07503,R10623,R10624	RC01911	ko00000,ko00001,ko00002,ko01000	-	-	-	Tocopherol_cycl
k59_1789361_1	1121406.JAEX01000024_gene2497	1.24e-162	459.0	28HJ7@1|root,2Z7UE@2|Bacteria,1R7W6@1224|Proteobacteria,42NK3@68525|delta/epsilon subdivisions,2WJD5@28221|Deltaproteobacteria,2M911@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_788609_2	1121447.JONL01000013_gene3685	1.11e-27	108.0	COG5619@1|root,COG5619@2|Bacteria,1RIE1@1224|Proteobacteria,430QN@68525|delta/epsilon subdivisions,2WVMT@28221|Deltaproteobacteria,2MF44@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Uncharacterized conserved protein (DUF2290)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2290
k59_616971_2	1123514.KB905899_gene1969	3.63e-09	55.5	COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,1SCC7@1236|Gammaproteobacteria,461D2@72273|Thiotrichales	72273|Thiotrichales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_616971_3	1366050.N234_02370	2.87e-13	66.2	COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,2VR31@28216|Betaproteobacteria,1K3IP@119060|Burkholderiaceae	28216|Betaproteobacteria	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
k59_323992_1	87626.PTD2_12179	7.57e-22	95.1	COG1843@1|root,COG1843@2|Bacteria,1MXCG@1224|Proteobacteria,1RPZI@1236|Gammaproteobacteria,2PZS9@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	N	Required for flagellar hook formation. May act as a scaffolding protein	flgD	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FLgD_tudor,FlgD,FlgD_ig
k59_323992_2	349521.HCH_04479	6.25e-26	107.0	COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,1RMWX@1236|Gammaproteobacteria,1XJGP@135619|Oceanospirillales	135619|Oceanospirillales	N	Flagellar hook protein flgE	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
k59_47049_1	177437.HRM2_33040	9.88e-29	120.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NHP@68525|delta/epsilon subdivisions,2X6U1@28221|Deltaproteobacteria,2MHMI@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM ribonuclease II	-	-	3.1.13.1	ko:K01147,ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_1675021_1	1232410.KI421417_gene2727	1.43e-07	56.6	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,42N9J@68525|delta/epsilon subdivisions,2X2B8@28221|Deltaproteobacteria,43U8G@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	-	-	-	-	-	-	-	-	-	Toluene_X
k59_206754_1	1118235.CAJH01000051_gene3051	8.77e-52	172.0	COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,1RU35@1236|Gammaproteobacteria,1X3JV@135614|Xanthomonadales	135614|Xanthomonadales	KT	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	tcsR	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_676471_1	549.BW31_02959	8.1e-115	356.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,3VZV3@53335|Pantoea	1236|Gammaproteobacteria	G	4-alpha-glucanotransferase	malQ	GO:0000023,GO:0000025,GO:0003674,GO:0003824,GO:0004133,GO:0004134,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005984,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0055114,GO:0071704,GO:1901575	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	iECIAI1_1343.ECIAI1_3560,iECO111_1330.ECO111_4225,iECO26_1355.ECO26_4504,iEcE24377_1341.EcE24377A_3892,iUMNK88_1353.UMNK88_4184,iYL1228.KPN_03786	Glyco_hydro_77
k59_1380036_2	1454010.JEOE01000013_gene2288	1.29e-101	303.0	COG0560@1|root,COG0560@2|Bacteria,2GJW9@201174|Actinobacteria,4F0I8@85016|Cellulomonadaceae	201174|Actinobacteria	E	haloacid dehalogenase-like hydrolase	serB1	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HAD
k59_398465_1	367299.JOEE01000005_gene3637	1.22e-112	338.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,4FFET@85021|Intrasporangiaceae	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_1789385_1	1454004.AW11_00158	1.7e-27	112.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2VIBZ@28216|Betaproteobacteria,1KQP5@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	NAD(P)H-binding	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
k59_1023531_1	471853.Bcav_3270	7.57e-47	156.0	COG0569@1|root,COG0569@2|Bacteria,2IA09@201174|Actinobacteria	201174|Actinobacteria	P	domain protein	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_47092_1	472759.Nhal_3142	1.08e-78	264.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales	135613|Chromatiales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1732410_1	864051.BurJ1DRAFT_0531	1.82e-52	176.0	COG2010@1|root,COG2010@2|Bacteria,1REKI@1224|Proteobacteria	1224|Proteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_280020_2	1200792.AKYF01000005_gene3321	3.84e-75	227.0	COG0197@1|root,COG0197@2|Bacteria,1V1AY@1239|Firmicutes,4HFPN@91061|Bacilli,26WYM@186822|Paenibacillaceae	91061|Bacilli	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
k59_926901_1	519989.ECTPHS_05430	3.21e-98	300.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WWEY@135613|Chromatiales	135613|Chromatiales	C	FAD linked oxidase	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_926901_2	768671.ThimaDRAFT_1041	5.22e-94	288.0	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,1RN4G@1236|Gammaproteobacteria,1WX7V@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD linked oxidase domain protein	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1338238_1	523791.Kkor_2493	1.44e-103	328.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XI69@135619|Oceanospirillales	135619|Oceanospirillales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1732413_1	1266914.ATUK01000016_gene446	4.83e-84	266.0	COG4191@1|root,COG4191@2|Bacteria,1QVHZ@1224|Proteobacteria,1S2DC@1236|Gammaproteobacteria,1WZY5@135613|Chromatiales	135613|Chromatiales	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_1732413_2	713586.KB900536_gene936	9.36e-50	172.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1S1NC@1236|Gammaproteobacteria,1X06R@135613|Chromatiales	135613|Chromatiales	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1440120_1	1487923.DP73_19355	4.74e-07	57.4	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,261BU@186807|Peptococcaceae	186801|Clostridia	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1440120_2	1121918.ARWE01000001_gene1120	7.77e-47	158.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42PYJ@68525|delta/epsilon subdivisions,2WKHY@28221|Deltaproteobacteria,43SDA@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1732422_1	977880.RALTA_A1453	9.76e-70	238.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria,1K0RI@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_1095937_1	1037409.BJ6T_45600	8.78e-15	79.7	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2TS02@28211|Alphaproteobacteria,3JT9N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldo/keto reductase family	MA20_36140	-	1.1.1.91	ko:K05882	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
k59_105010_1	762982.HMPREF9442_02797	1.05e-28	121.0	COG3291@1|root,COG3507@1|root,COG3291@2|Bacteria,COG3507@2|Bacteria,4NYTZ@976|Bacteroidetes,2G11V@200643|Bacteroidia	976|Bacteroidetes	G	Ricin-type beta-trefoil lectin domain-like	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,RicinB_lectin_2
k59_1270263_1	1121875.KB907547_gene2995	1.06e-13	74.7	COG2067@1|root,COG2067@2|Bacteria,4NX18@976|Bacteroidetes,1I5D9@117743|Flavobacteriia	976|Bacteroidetes	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1789410_1	870187.Thini_1993	3.44e-89	274.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria,45ZZ1@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
k59_499844_1	267747.PPA2228	6.59e-35	120.0	COG0238@1|root,COG0238@2|Bacteria,2IQ92@201174|Actinobacteria,4DRVS@85009|Propionibacteriales	201174|Actinobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
k59_499844_2	1035308.AQYY01000002_gene438	1.88e-34	120.0	COG0359@1|root,COG0359@2|Bacteria,1V6QG@1239|Firmicutes,24MT6@186801|Clostridia	186801|Clostridia	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
k59_986098_1	590998.Celf_1857	1.77e-152	455.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4F0M6@85016|Cellulomonadaceae	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_499851_1	1397527.Q670_05380	4.64e-196	556.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1XHAH@135619|Oceanospirillales	135619|Oceanospirillales	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,Pribosyltran
k59_1142128_2	697282.Mettu_0389	3.37e-35	126.0	COG2236@1|root,COG2236@2|Bacteria,1RKB0@1224|Proteobacteria,1S7J1@1236|Gammaproteobacteria,1XFMX@135618|Methylococcales	135618|Methylococcales	F	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
k59_1023571_1	316056.RPC_4507	5.7e-88	259.0	COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,2UDW5@28211|Alphaproteobacteria,3K4D3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_1338308_1	1279017.AQYJ01000026_gene57	1.98e-68	232.0	COG1360@1|root,COG2885@1|root,COG1360@2|Bacteria,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,1T4AK@1236|Gammaproteobacteria,46ACU@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,OmpA
k59_398581_1	1304872.JAGC01000009_gene977	9.13e-68	220.0	COG0659@1|root,COG0659@2|Bacteria,1MX1U@1224|Proteobacteria,42QCR@68525|delta/epsilon subdivisions,2WIP7@28221|Deltaproteobacteria,2MGK3@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Molybdate transporter of MFS superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_MOT1
k59_986115_1	519989.ECTPHS_12074	6.6e-128	373.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1WWR6@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator, LysR	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_986115_2	870187.Thini_1183	8.44e-310	845.0	COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,1RRMX@1236|Gammaproteobacteria,4604Y@72273|Thiotrichales	72273|Thiotrichales	G	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site	cbbL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
k59_1095982_1	644282.Deba_1447	1.64e-19	89.0	COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,42PJC@68525|delta/epsilon subdivisions,2WJB9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_504155_1	933262.AXAM01000034_gene1559	7.22e-48	170.0	COG0664@1|root,COG0664@2|Bacteria,1R8R8@1224|Proteobacteria,42PH6@68525|delta/epsilon subdivisions,2WKQJ@28221|Deltaproteobacteria,2MJ5X@213118|Desulfobacterales	28221|Deltaproteobacteria	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_152778_2	1123393.KB891316_gene2122	7.64e-65	206.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2VJAS@28216|Betaproteobacteria,1KT21@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
k59_1560443_1	1121013.P873_05875	1.35e-100	315.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,1X39Z@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_53406_1	765912.Thimo_1923	1.48e-09	55.1	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria,1WYKM@135613|Chromatiales	135613|Chromatiales	S	RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_1100745_1	335543.Sfum_3619	7.45e-104	308.0	COG0519@1|root,COG0519@2|Bacteria,1NR5X@1224|Proteobacteria,42YTH@68525|delta/epsilon subdivisions,2WUIJ@28221|Deltaproteobacteria,2MR8H@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	GMP synthase C terminal domain	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GMP_synt_C,NAD_synthase
k59_1793289_1	471853.Bcav_2543	1.17e-74	241.0	COG0541@1|root,COG0541@2|Bacteria,2GK4R@201174|Actinobacteria	201174|Actinobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_1793289_2	446471.Xcel_1166	2.12e-21	93.2	COG1228@1|root,COG1228@2|Bacteria,2GKRZ@201174|Actinobacteria,4F3ZV@85017|Promicromonosporaceae	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_562723_1	1454004.AW11_03199	1.26e-54	176.0	COG5156@1|root,COG5156@2|Bacteria,1N53Q@1224|Proteobacteria,2W66Z@28216|Betaproteobacteria	28216|Betaproteobacteria	DO	anaphase-promoting complex-dependent catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1560464_1	324925.Ppha_1956	1.12e-51	177.0	COG0535@1|root,COG1433@1|root,COG0535@2|Bacteria,COG1433@2|Bacteria,1FDRX@1090|Chlorobi	1090|Chlorobi	C	TIGRFAM nitrogenase cofactor biosynthesis protein NifB	-	-	-	ko:K02585	-	-	-	-	ko00000	-	-	-	Fer4_14,Nitro_FeMo-Co,Radical_SAM
k59_1509611_2	768671.ThimaDRAFT_3812	1.52e-54	176.0	COG1376@1|root,COG1376@2|Bacteria,1RHBG@1224|Proteobacteria,1S6DY@1236|Gammaproteobacteria,1X25T@135613|Chromatiales	135613|Chromatiales	S	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_211194_1	1463855.JOHV01000032_gene884	8.84e-08	55.1	COG0711@1|root,COG0711@2|Bacteria,2GNBF@201174|Actinobacteria	201174|Actinobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_211194_2	2074.JNYD01000013_gene6849	1.19e-48	161.0	COG0669@1|root,COG0669@2|Bacteria,2GN1S@201174|Actinobacteria,4E33S@85010|Pseudonocardiales	201174|Actinobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016043,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0022607,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034214,GO:0034641,GO:0034654,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0055086,GO:0065003,GO:0070566,GO:0071704,GO:0071840,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_211194_3	1051006.HMPREF1162_0930	1.21e-25	103.0	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4DQZ1@85009|Propionibacteriales	201174|Actinobacteria	L	Conserved hypothetical protein 95	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
k59_739683_1	717231.Flexsi_0440	7.24e-73	232.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1345162_1	1149133.ppKF707_4811	1.95e-65	213.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,1YDGB@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	P	Chromate transporter	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_445570_2	1120797.KB908275_gene2539	7.19e-30	115.0	COG0725@1|root,COG0725@2|Bacteria,2GMPF@201174|Actinobacteria,234BP@1762|Mycobacteriaceae	201174|Actinobacteria	P	ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
k59_1275329_2	1249627.D779_0094	4.75e-82	270.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RMPV@1236|Gammaproteobacteria,1WW6H@135613|Chromatiales	135613|Chromatiales	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_933645_2	768671.ThimaDRAFT_2919	1.96e-21	95.1	2CARE@1|root,2Z8Q5@2|Bacteria,1R7S8@1224|Proteobacteria,1RRAH@1236|Gammaproteobacteria,1WW2H@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM CRISPR-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Cas6
k59_1345173_1	375286.mma_2596	9.26e-67	209.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2VUIT@28216|Betaproteobacteria,476WJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
k59_1560474_1	1121405.dsmv_0483	3.27e-128	379.0	COG1418@1|root,COG1418@2|Bacteria,1P7YA@1224|Proteobacteria,42KZ8@68525|delta/epsilon subdivisions,2WJG1@28221|Deltaproteobacteria,2MHS7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
k59_1873411_1	545264.KB898746_gene818	1.62e-94	299.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1WWWW@135613|Chromatiales	135613|Chromatiales	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
k59_933653_1	233412.HD_0922	1.51e-07	53.9	COG1705@1|root,COG3772@1|root,COG1705@2|Bacteria,COG3772@2|Bacteria,1MV52@1224|Proteobacteria,1RNVH@1236|Gammaproteobacteria,1Y6T8@135625|Pasteurellales	135625|Pasteurellales	NU	Integrating conjugative element protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_933653_2	877418.ATWV01000003_gene640	2.01e-09	61.2	COG1256@1|root,COG1256@2|Bacteria,2J5TQ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-associated protein, FlgK	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,Flg_bbr_C
k59_1444448_1	1123392.AQWL01000008_gene1234	5.12e-51	163.0	2CE1N@1|root,32RYY@2|Bacteria,1N23N@1224|Proteobacteria,2VU21@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1444448_2	1117108.PAALTS15_18193	4.26e-43	144.0	COG3628@1|root,COG3628@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K06903	-	-	-	-	ko00000	-	-	-	GPW_gp25
k59_1444448_3	926560.KE387023_gene1990	4.95e-51	183.0	COG3299@1|root,COG3299@2|Bacteria	2|Bacteria	S	Baseplate J-like protein	yqbT1	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
k59_992911_1	1267005.KB911257_gene987	3.49e-100	299.0	COG3176@1|root,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,2TUVA@28211|Alphaproteobacteria,3N6YK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Acetyltransferase (GNAT) domain	olsB	-	2.3.2.30	ko:K22310	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_5
k59_211214_1	933262.AXAM01000017_gene3105	4.97e-57	194.0	COG4191@1|root,COG4191@2|Bacteria,1R9AK@1224|Proteobacteria,42Q2G@68525|delta/epsilon subdivisions,2WM8Y@28221|Deltaproteobacteria,2MI84@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_405363_1	367299.JOEE01000004_gene1411	1.05e-28	111.0	COG1090@1|root,COG1090@2|Bacteria,2GJS0@201174|Actinobacteria,4FEWU@85021|Intrasporangiaceae	201174|Actinobacteria	S	epimerase	-	GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0030312,GO:0031073,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0046906,GO:0048037,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
k59_405363_2	1380356.JNIK01000021_gene4508	9.17e-74	239.0	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4ERCG@85013|Frankiales	201174|Actinobacteria	C	TIGRFAM 2-oxoglutarate dehydrogenase, E2 component	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_286323_1	247490.KSU1_C1703	1.5e-37	137.0	COG4424@1|root,COG4424@2|Bacteria	2|Bacteria	S	carbohydrate metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1,Sulfotransfer_3
k59_1793316_1	1122135.KB893134_gene3556	2.11e-80	246.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TTC8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	mtkB	-	6.2.1.5,6.2.1.9	ko:K01902,ko:K08692	ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00346,M00374,M00620	R00405,R01256,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_328541_1	1218076.BAYB01000008_gene1507	2.27e-49	182.0	COG2197@1|root,COG3899@1|root,COG2197@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VKH1@28216|Betaproteobacteria,1JZT2@119060|Burkholderiaceae	28216|Betaproteobacteria	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Guanylate_cyc,Pkinase,SAM_1
k59_1027436_1	697282.Mettu_3691	2.12e-52	193.0	COG0642@1|root,COG4191@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RR5W@1236|Gammaproteobacteria,1XE73@135618|Methylococcales	135618|Methylococcales	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_9
k59_1560496_2	85643.Tmz1t_0227	2.84e-43	148.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2VIT4@28216|Betaproteobacteria,2KUNU@206389|Rhodocyclales	206389|Rhodocyclales	K	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1560498_1	715226.ABI_41880	1.02e-91	281.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2TQMA@28211|Alphaproteobacteria,2KHKQ@204458|Caulobacterales	204458|Caulobacterales	C	Cytochrome bd terminal oxidase subunit I	-	-	-	-	-	-	-	-	-	-	-	-	Cyt_bd_oxida_I
k59_1027442_1	367299.JOEE01000002_gene2403	6.56e-66	213.0	COG1271@1|root,COG1271@2|Bacteria,2GJE4@201174|Actinobacteria,4FFIS@85021|Intrasporangiaceae	201174|Actinobacteria	C	cytochrome bd ubiquinol oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_1100804_2	757424.Hsero_2055	1.2e-08	57.4	COG2882@1|root,COG2882@2|Bacteria,1N4IX@1224|Proteobacteria,2VUIK@28216|Betaproteobacteria,47909@75682|Oxalobacteraceae	28216|Betaproteobacteria	N	flagellar	fliJ	-	-	ko:K02413	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliJ
k59_1345222_1	393595.ABO_0430	2.93e-61	193.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,1XJHS@135619|Oceanospirillales	135619|Oceanospirillales	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_1736873_1	221109.22778821	4.24e-58	188.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,4HAB1@91061|Bacilli,23K0N@182709|Oceanobacillus	91061|Bacilli	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	iSB619.SA_RS06920	ABC_tran
k59_1618728_1	96561.Dole_0775	6.43e-71	231.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2WIJS@28221|Deltaproteobacteria,2MHY5@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
k59_1209258_1	1121017.AUFG01000024_gene2095	2.63e-80	255.0	COG1140@1|root,COG1140@2|Bacteria,2GJ8P@201174|Actinobacteria,4FFT8@85021|Intrasporangiaceae	201174|Actinobacteria	C	the beta subunit is an iron sulfur cluster containing electron transfer subunit	narH	-	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Fer4_11,Nitr_red_bet_C
k59_328561_1	243233.MCA0540	2.07e-10	63.2	COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1S5KU@1236|Gammaproteobacteria,1XDYF@135618|Methylococcales	135618|Methylococcales	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_328561_2	123899.JPQP01000004_gene524	1.54e-21	94.4	COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1MV72@1224|Proteobacteria,2VI9K@28216|Betaproteobacteria,3T1JD@506|Alcaligenaceae	28216|Betaproteobacteria	C	Catalyzes the formation of 3,6-dideoxy-D-glycero-D-glycero-4-hexulose	ascD	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
k59_1384741_2	768671.ThimaDRAFT_2776	4.69e-85	259.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1WXI2@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_739739_1	926569.ANT_17960	3.72e-93	285.0	COG0719@1|root,COG0719@2|Bacteria,2G5S8@200795|Chloroflexi	200795|Chloroflexi	O	TIGRFAM FeS assembly protein SufD	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_562787_1	550540.Fbal_1923	9.7e-50	165.0	2C7KN@1|root,30RKS@2|Bacteria,1N486@1224|Proteobacteria,1T684@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_405414_1	765913.ThidrDRAFT_4135	5.38e-74	234.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RSN1@1236|Gammaproteobacteria,1WVUQ@135613|Chromatiales	135613|Chromatiales	I	PFAM Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	DDE_Tnp_ISL3,FA_desaturase
k59_1146578_2	983545.Glaag_3084	4.98e-35	131.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,466CJ@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iSFV_1184.SFV_0382	AIRS,AIRS_C
k59_54329_1	635013.TherJR_0853	4.87e-56	188.0	COG1294@1|root,COG1294@2|Bacteria,1TRYV@1239|Firmicutes,24CPA@186801|Clostridia,261EQ@186807|Peptococcaceae	186801|Clostridia	C	oxidase, subunit II	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
k59_934386_1	713586.KB900536_gene1715	4.01e-40	136.0	COG0776@1|root,COG0776@2|Bacteria,1RFWH@1224|Proteobacteria,1S5GE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Belongs to the bacterial histone-like protein family	VL23_14575	-	-	-	-	-	-	-	-	-	-	-	Bac_DNA_binding
k59_211774_1	933262.AXAM01000055_gene1253	3.7e-76	236.0	COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,42Q4U@68525|delta/epsilon subdivisions,2WJ08@28221|Deltaproteobacteria,2MI4K@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_681649_1	472759.Nhal_2360	1.72e-108	322.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1WX0P@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_1346012_1	1126627.BAWE01000005_gene6111	7.28e-16	83.2	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_621954_1	247490.KSU1_C0781	9.88e-27	108.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_621954_2	1429046.RR21198_2524	5.52e-53	180.0	COG3319@1|root,COG3319@2|Bacteria,2GJ5V@201174|Actinobacteria	201174|Actinobacteria	Q	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	DUF900
k59_1444992_1	314278.NB231_08127	5.8e-161	494.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_446132_1	1713.JOFV01000003_gene1551	4.13e-14	77.4	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4F273@85016|Cellulomonadaceae	201174|Actinobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
k59_329116_1	1265505.ATUG01000001_gene3367	3.97e-85	258.0	COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,42MNY@68525|delta/epsilon subdivisions,2WJ6C@28221|Deltaproteobacteria,2MI5J@213118|Desulfobacterales	28221|Deltaproteobacteria	F	CobB/CobQ-like glutamine amidotransferase domain	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
k59_1561058_1	261292.Nit79A3_2905	2.89e-82	260.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,2VJIQ@28216|Betaproteobacteria,372GH@32003|Nitrosomonadales	28216|Betaproteobacteria	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
k59_792661_1	1123261.AXDW01000007_gene2270	9.2e-124	367.0	COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1X2YI@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_211788_1	1123368.AUIS01000003_gene1787	2.34e-44	163.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,2NCC6@225057|Acidithiobacillales	1236|Gammaproteobacteria	P	Cation transport ATPase (P-type)	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_54383_1	710696.Intca_3501	1.58e-34	119.0	COG2026@1|root,COG2026@2|Bacteria,2GRQR@201174|Actinobacteria,4FJ7R@85021|Intrasporangiaceae	201174|Actinobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
k59_54383_2	710696.Intca_3502	1.95e-39	133.0	COG2161@1|root,COG2161@2|Bacteria,2GRC8@201174|Actinobacteria,4FJ8S@85021|Intrasporangiaceae	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
k59_1385309_1	1304883.KI912532_gene953	3.23e-132	399.0	COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,2VIV2@28216|Betaproteobacteria,2KVXE@206389|Rhodocyclales	206389|Rhodocyclales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_934438_1	1239962.C943_00877	2.3e-74	241.0	COG2192@1|root,COG2192@2|Bacteria,4NEV9@976|Bacteroidetes,47JR5@768503|Cytophagia	976|Bacteroidetes	O	PFAM Carbamoyltransferase	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
k59_993689_1	649831.L083_2981	6.28e-25	103.0	COG3146@1|root,COG3146@2|Bacteria,2IK34@201174|Actinobacteria	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	Acetyltransf_6,FemAB_like
k59_993689_2	487521.OCU_30760	8.01e-26	112.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,233YJ@1762|Mycobacteriaceae	201174|Actinobacteria	Q	Peptide synthetase	-	-	-	ko:K16228,ko:K16229	-	-	-	-	ko00000	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_12,NAD_binding_4,PP-binding,Thioesterase
k59_993691_1	1366050.N234_16655	4.21e-16	79.0	COG0110@1|root,COG0110@2|Bacteria,1MZ7U@1224|Proteobacteria,2VVVZ@28216|Betaproteobacteria,1K3EF@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	ko:K13006,ko:K19429	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2
k59_1627755_1	526227.Mesil_2630	1.9e-14	71.2	COG0607@1|root,COG0607@2|Bacteria,1WMYS@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1218645_1	1231190.NA8A_22556	1.12e-65	217.0	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2TT9X@28211|Alphaproteobacteria,43PMR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_161998_1	1121405.dsmv_1661	1.32e-158	458.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,42M5M@68525|delta/epsilon subdivisions,2WM27@28221|Deltaproteobacteria,2MJRK@213118|Desulfobacterales	28221|Deltaproteobacteria	C	cytochrome c oxidase	ccoN	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_1453990_1	1454004.AW11_03945	2.36e-87	265.0	COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,2VKSE@28216|Betaproteobacteria,1KQW1@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_1453990_2	1298593.TOL_2643	3.14e-06	48.9	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1XH4B@135619|Oceanospirillales	135619|Oceanospirillales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_1746499_1	768670.Calni_0468	2.38e-07	56.6	2E05E@1|root,305MD@2|Bacteria,2GGJD@200930|Deferribacteres	200930|Deferribacteres	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1746505_1	1169152.AXVD01000038_gene1735	3.85e-15	80.5	COG0739@1|root,COG0741@1|root,COG0739@2|Bacteria,COG0741@2|Bacteria,2I54D@201174|Actinobacteria,4G9ME@85025|Nocardiaceae	201174|Actinobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23,SLT,SLT_2,Transglycosylas
k59_1154363_2	292415.Tbd_1047	2.11e-63	207.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VIPR@28216|Betaproteobacteria,1KRKX@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_1746507_1	1121930.AQXG01000004_gene2915	4.43e-05	45.1	COG0711@1|root,COG0711@2|Bacteria,4NP9T@976|Bacteroidetes,1IYX4@117747|Sphingobacteriia	976|Bacteroidetes	C	ATP synthase B/B' CF(0)	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
k59_1746507_2	857087.Metme_0841	6.17e-42	139.0	COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,1SA80@1236|Gammaproteobacteria,1XFH6@135618|Methylococcales	135618|Methylococcales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_1570780_2	931627.MycrhDRAFT_2955	2.41e-31	122.0	COG0365@1|root,COG0365@2|Bacteria,2GNE8@201174|Actinobacteria,237PW@1762|Mycobacteriaceae	201174|Actinobacteria	I	synthetase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_572725_1	219305.MCAG_02259	4.52e-24	101.0	COG1609@1|root,COG1609@2|Bacteria,2GJV7@201174|Actinobacteria,4DASY@85008|Micromonosporales	201174|Actinobacteria	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
k59_750052_1	1150600.ADIARSV_3461	1.1e-07	58.9	COG1538@1|root,COG1538@2|Bacteria,4NE4S@976|Bacteroidetes,1IR82@117747|Sphingobacteriia	976|Bacteroidetes	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_514152_1	644968.DFW101_2477	4.03e-13	73.9	COG0438@1|root,COG0438@2|Bacteria,1N7PP@1224|Proteobacteria,435P7@68525|delta/epsilon subdivisions,2X02U@28221|Deltaproteobacteria,2MA39@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
k59_1112790_1	626887.J057_23535	1.65e-50	172.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,465ZM@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006520,GO:0006553,GO:0006563,GO:0006564,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0034641,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046394,GO:0046451,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901615,GO:1901617	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iEcE24377_1341.EcE24377A_1004,iPC815.YPO1389,iYL1228.KPN_00935	Aminotran_5
k59_1039267_1	391037.Sare_4352	2.04e-42	150.0	COG1793@1|root,COG1793@2|Bacteria,2IKE5@201174|Actinobacteria,4DAVP@85008|Micromonosporales	201174|Actinobacteria	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
k59_1039267_2	1077972.ARGLB_027_01180	3.83e-15	73.9	COG1273@1|root,COG1273@2|Bacteria,2GJMU@201174|Actinobacteria,1W8QJ@1268|Micrococcaceae	201174|Actinobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050790,GO:0050896,GO:0051340,GO:0051351,GO:0051716,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
k59_691079_1	656024.FsymDg_0184	1.09e-42	154.0	COG0705@1|root,COG0705@2|Bacteria,2GJYG@201174|Actinobacteria,4ESUX@85013|Frankiales	201174|Actinobacteria	NU	PFAM Rhomboid family	yggP	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid,zf-B_box
k59_1747426_1	66373.JOFQ01000037_gene2320	1.04e-31	127.0	COG0477@1|root,COG0477@2|Bacteria,2GJ7J@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_1155203_1	716544.wcw_1074	1.3e-13	75.5	COG1519@1|root,COG1519@2|Bacteria,2JFFN@204428|Chlamydiae	204428|Chlamydiae	M	Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of three 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide- 1,4'-bisphosphate precursor of lipid A. Thus generates the genus- specific LPS epitope of Chlamydia, composed of the trisaccharide alpha-Kdo-(2- 8)-alpha-Kdo-(2- 4)-alpha-Kdo	waaA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
k59_1628945_1	768671.ThimaDRAFT_4053	1.26e-117	338.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria,1WWRN@135613|Chromatiales	135613|Chromatiales	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
k59_1628946_1	223184.AS25_13395	1.09e-171	488.0	COG5421@1|root,COG5421@2|Bacteria,2GK2A@201174|Actinobacteria,1W9MV@1268|Micrococcaceae	201174|Actinobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1112817_1	1267005.KB911257_gene768	9.42e-96	306.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07239	-	-	-	-	ko00000	2.A.6.1	-	-	ACR_tran
k59_1219745_1	933262.AXAM01000086_gene2639	2.75e-80	249.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,42PIH@68525|delta/epsilon subdivisions,2WJH2@28221|Deltaproteobacteria,2MIKZ@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
k59_750086_1	1056820.KB900629_gene1818	4.53e-41	148.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,2PNX3@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_1521690_1	289376.THEYE_A0388	8.11e-23	104.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,3J0XX@40117|Nitrospirae	40117|Nitrospirae	I	CoA enzyme activase uncharacterised domain (DUF2229)	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
k59_339326_1	1265505.ATUG01000002_gene2373	2.94e-27	105.0	COG1309@1|root,COG1309@2|Bacteria,1R7JI@1224|Proteobacteria,43AJM@68525|delta/epsilon subdivisions,2X5ZU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
k59_221282_1	1499686.BN1079_02296	1.17e-121	346.0	COG0454@1|root,COG0456@2|Bacteria,1NII2@1224|Proteobacteria,1SJB0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1628970_1	765912.Thimo_2417	3.9e-52	179.0	COG0420@1|root,COG0420@2|Bacteria,1MXMJ@1224|Proteobacteria,1S1DQ@1236|Gammaproteobacteria,1WXH5@135613|Chromatiales	135613|Chromatiales	L	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_163110_1	1249627.D779_3949	5.9e-15	70.5	COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,1S343@1236|Gammaproteobacteria,1WXZR@135613|Chromatiales	135613|Chromatiales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_163110_2	1249627.D779_3948	2.04e-36	133.0	COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,1RRRE@1236|Gammaproteobacteria,1WVUP@135613|Chromatiales	135613|Chromatiales	M	Lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_1521713_1	936136.ARRT01000006_gene4621	7.36e-63	216.0	COG0457@1|root,COG0607@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0607@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,HEAT_2,Rhodanese,TPR_16,TPR_19,TPR_8,TolB_N
k59_1628978_1	1211115.ALIQ01000247_gene25	1.81e-131	382.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2TRZZ@28211|Alphaproteobacteria,3NAMD@45404|Beijerinckiaceae	28211|Alphaproteobacteria	H	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
k59_1628978_2	1502851.FG93_04385	7.45e-08	52.8	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_1747463_1	509191.AEDB02000035_gene2213	1.07e-92	298.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia,3WGW0@541000|Ruminococcaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1287598_1	396588.Tgr7_0696	6.48e-86	271.0	COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1WWFZ@135613|Chromatiales	135613|Chromatiales	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase
k59_800078_1	945713.IALB_2287	1.8e-15	77.8	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	sigH	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1521723_1	1122604.JONR01000050_gene3127	5.32e-84	255.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,1X31A@135614|Xanthomonadales	135614|Xanthomonadales	S	abc transporter atp-binding protein	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
k59_163124_1	374847.Kcr_0804	4.5e-42	160.0	arCOG03462@1|root,arCOG03462@2157|Archaea	2157|Archaea	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_631827_1	1122218.KB893653_gene497	5.49e-82	262.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2TQVI@28211|Alphaproteobacteria,1JQUP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1747470_1	1392502.JNIO01000002_gene432	4.55e-57	196.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,4H1XW@909932|Negativicutes	909932|Negativicutes	H	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_1287607_1	686340.Metal_1376	9.63e-09	63.9	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1XDTR@135618|Methylococcales	135618|Methylococcales	G	alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1039355_1	1249627.D779_0025	4.38e-97	311.0	COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,1WXH7@135613|Chromatiales	135613|Chromatiales	I	SMART Phospholipid glycerol acyltransferase	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase,MFS_1
k59_691133_1	526225.Gobs_0311	1.88e-07	54.7	COG0601@1|root,COG0601@2|Bacteria,2GK0Z@201174|Actinobacteria,4ETSF@85013|Frankiales	201174|Actinobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_691133_2	1499967.BAYZ01000043_gene2289	1.94e-171	499.0	COG0747@1|root,COG0747@2|Bacteria	2|Bacteria	E	dipeptide transport	appA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5,SLH
k59_1570864_1	235985.BBPN01000009_gene3769	2.59e-122	371.0	COG1236@1|root,COG1236@2|Bacteria,2HEXB@201174|Actinobacteria,2NK0D@228398|Streptacidiphilus	201174|Actinobacteria	J	Zn-dependent metallo-hydrolase RNA specificity domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL
k59_1570864_2	1218084.BBJK01000101_gene6335	3.74e-07	53.1	COG0524@1|root,COG0524@2|Bacteria,1MV5B@1224|Proteobacteria,2VR36@28216|Betaproteobacteria,1K6KS@119060|Burkholderiaceae	28216|Betaproteobacteria	G	pfkB family carbohydrate kinase	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_1521753_1	1123371.ATXH01000001_gene1229	2.81e-63	199.0	COG0440@1|root,COG0440@2|Bacteria,2GH4Y@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	ACT domain	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5,ALS_ss_C
k59_867377_1	1101190.ARWB01000001_gene1275	5.27e-73	234.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,36XSE@31993|Methylocystaceae	28211|Alphaproteobacteria	H	Aminotransferase class-III	-	-	2.6.1.18	ko:K00822	ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100	-	R00907,R04187	RC00008,RC00062,RC00160	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_691149_1	112098.XP_008603689.1	2.32e-50	177.0	COG0498@1|root,KOG2616@2759|Eukaryota	2759|Eukaryota	E	2-oxobutyrate metabolic process	THR4	GO:0003674,GO:0003824,GO:0004795,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006082,GO:0006520,GO:0006566,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016311,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
k59_1455127_1	314278.NB231_00105	7.26e-181	535.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales	135613|Chromatiales	D	DNA segregation ATPase FtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1455127_2	472759.Nhal_3421	4.77e-78	244.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria,1WXVZ@135613|Chromatiales	135613|Chromatiales	C	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_1690046_1	1163617.SCD_n01585	3.59e-96	297.0	COG1032@1|root,COG1032@2|Bacteria,1MUMS@1224|Proteobacteria,2VZ32@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_750155_1	446471.Xcel_0236	1.51e-89	278.0	COG5297@1|root,COG5297@2|Bacteria,2GK39@201174|Actinobacteria,4F424@85017|Promicromonosporaceae	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase family 6	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_2,Glyco_hydro_6
k59_1690054_1	330214.NIDE3374	1.41e-54	184.0	28I4Y@1|root,2Z88D@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_867390_1	485913.Krac_7969	7.1e-80	251.0	COG4992@1|root,COG4992@2|Bacteria	2|Bacteria	E	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	patA	-	2.6.1.11,2.6.1.17,2.6.1.82	ko:K00821,ko:K05830,ko:K09251	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00031,M00763,M00845	R01155,R02283,R04475,R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1455147_1	1424334.W822_12990	8.98e-06	50.8	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,2VHI3@28216|Betaproteobacteria,3T2K8@506|Alcaligenaceae	28216|Betaproteobacteria	I	Fatty acid	fadL	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_1570915_1	43759.JNWK01000051_gene8141	2.21e-43	154.0	COG0451@1|root,COG0451@2|Bacteria,2GNH5@201174|Actinobacteria	201174|Actinobacteria	GM	NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_1287679_1	1469245.JFBG01000019_gene1134	1.38e-151	431.0	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,1SBBX@1236|Gammaproteobacteria,1X060@135613|Chromatiales	135613|Chromatiales	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_800127_1	367299.JOEE01000004_gene1247	6.32e-105	327.0	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4FEB5@85021|Intrasporangiaceae	201174|Actinobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_1629057_1	935261.JAGL01000007_gene2537	1.64e-06	48.9	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2TRNY@28211|Alphaproteobacteria,43GSX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
k59_1629057_2	1120956.JHZK01000006_gene691	1.01e-63	197.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2U72U@28211|Alphaproteobacteria,1JP5G@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Pfam:DUF59	MA20_30700	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
k59_572835_1	1389489.O159_09430	2.12e-15	70.5	COG3360@1|root,COG3360@2|Bacteria,2HSRK@201174|Actinobacteria,4FQ19@85023|Microbacteriaceae	201174|Actinobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
k59_867423_1	391625.PPSIR1_03323	1.57e-109	327.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,43AEV@68525|delta/epsilon subdivisions,2X5YA@28221|Deltaproteobacteria,2YUMQ@29|Myxococcales	28221|Deltaproteobacteria	S	Nitronate monooxygenase	-	-	1.13.12.16,1.3.1.9	ko:K00459,ko:K02371	ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212	M00083	R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076,RC02541,RC02759	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO
k59_867423_2	379066.GAU_1377	2.43e-43	148.0	COG2050@1|root,COG2050@2|Bacteria,1ZV1I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Domain of unknown function (DUF4442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4442
k59_1155315_1	1231392.OCGS_1494	1.22e-20	96.7	COG2208@1|root,COG3437@1|root,COG2208@2|Bacteria,COG3437@2|Bacteria,1N4K5@1224|Proteobacteria,2TS77@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	response regulator	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HATPase_c_2,Response_reg,SpoIIE
k59_1287719_1	1173026.Glo7428_0932	2.57e-91	290.0	COG1216@1|root,COG5309@1|root,COG1216@2|Bacteria,COG5309@2|Bacteria,1G2MT@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glycos_transf_2
k59_1570950_1	471853.Bcav_0657	6.75e-129	394.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2GJU7@201174|Actinobacteria	201174|Actinobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
k59_572852_1	460265.Mnod_3315	2.06e-45	153.0	COG2220@1|root,COG2220@2|Bacteria,1MUY6@1224|Proteobacteria,2TV26@28211|Alphaproteobacteria,1JT6P@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
k59_1394891_1	446466.Cfla_0105	6.02e-80	261.0	COG0620@1|root,COG0620@2|Bacteria,2GIXA@201174|Actinobacteria,4F11H@85016|Cellulomonadaceae	201174|Actinobacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	metE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0040007,GO:0042084,GO:0042085,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050667,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_1,Meth_synt_2
k59_691228_1	864051.BurJ1DRAFT_2939	1.7e-101	318.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2VHUG@28216|Betaproteobacteria,1KNFB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	TIGRFAM TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1155332_1	395493.BegalDRAFT_2894	1.43e-67	210.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,460IU@72273|Thiotrichales	72273|Thiotrichales	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_221423_1	713587.THITH_02530	2.02e-57	183.0	COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,1S3PQ@1236|Gammaproteobacteria,1WXC4@135613|Chromatiales	135613|Chromatiales	L	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
k59_1570983_1	396588.Tgr7_2401	9.13e-14	74.3	2E02Y@1|root,32VRV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
k59_1747572_1	1267005.KB911258_gene400	1.85e-102	321.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2TRUM@28211|Alphaproteobacteria,3N6DK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	aminopeptidase N	pepN	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
k59_455623_1	1121434.AULY01000006_gene929	8.99e-68	228.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,43C4Y@68525|delta/epsilon subdivisions,2X7FA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_163263_1	706587.Desti_2042	2.52e-81	256.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_1629144_1	1298867.AUES01000037_gene748	9.32e-32	128.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria,2TY6Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	QU	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1039549_1	349102.Rsph17025_1218	2.99e-10	60.5	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2TRSZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA ligase	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
k59_521529_2	1317118.ATO8_00210	2.58e-20	89.0	COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,2TU8X@28211|Alphaproteobacteria,4KJZJ@93682|Roseivivax	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K01420,ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_581821_1	1333998.M2A_1804	2.85e-64	205.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,2TSR7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
k59_174112_1	519989.ECTPHS_06872	3.27e-86	266.0	COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,1RPY4@1236|Gammaproteobacteria,1WVV1@135613|Chromatiales	135613|Chromatiales	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
k59_1582250_1	745411.B3C1_04635	7.67e-38	144.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1J98P@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Domain of unknown function (DUF1974)	fadE	GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	iSbBS512_1146.SbBS512_E0217	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_1582250_2	999141.GME_02535	1.96e-154	441.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,1RMAX@1236|Gammaproteobacteria,1XIPA@135619|Oceanospirillales	135619|Oceanospirillales	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
k59_808569_2	1211579.PP4_07370	4.96e-37	135.0	COG0596@1|root,COG0596@2|Bacteria,1QIT9@1224|Proteobacteria,1RNP9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_640776_1	265072.Mfla_1409	1.28e-08	54.7	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2VHAZ@28216|Betaproteobacteria,2KM99@206350|Nitrosomonadales	206350|Nitrosomonadales	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
k59_640776_2	1439940.BAY1663_00266	2.21e-42	155.0	COG0466@1|root,COG1219@1|root,COG0466@2|Bacteria,COG1219@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004176,GO:0004252,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017171,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051603,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_761146_1	1249627.D779_1318	1.93e-63	215.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWMG@135613|Chromatiales	135613|Chromatiales	L	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_521557_1	580332.Slit_2777	6.78e-156	456.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,2VMUK@28216|Betaproteobacteria	28216|Betaproteobacteria	O	serine protease	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
k59_1053268_1	485916.Dtox_1820	9.76e-38	137.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,2644N@186807|Peptococcaceae	186801|Clostridia	L	Group II intron, maturase-specific domain	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_808583_1	666681.M301_0701	3.7e-23	97.4	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2VIP7@28216|Betaproteobacteria,2KMEX@206350|Nitrosomonadales	206350|Nitrosomonadales	C	Catalyzes the reversible hydration of fumarate to (S)- malate	-	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
k59_808583_2	765914.ThisiDRAFT_1141	3.49e-41	148.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1WX4J@135613|Chromatiales	135613|Chromatiales	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_761166_1	1265313.HRUBRA_01473	3.3e-86	272.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria,1J8WI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	AMP-binding enzyme	JD73_00810	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C_2,PP-binding
k59_1701205_2	1123065.ATWL01000015_gene2545	1.04e-98	296.0	COG0030@1|root,COG0030@2|Bacteria,2GKBT@201174|Actinobacteria	201174|Actinobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_1165312_2	1191523.MROS_0858	2.35e-95	296.0	COG0508@1|root,COG0508@2|Bacteria	2|Bacteria	C	S-acyltransferase activity	aceF	GO:0003674,GO:0003824,GO:0004742,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016407,GO:0016417,GO:0016418,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030523,GO:0031405,GO:0031406,GO:0032787,GO:0032991,GO:0033293,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1902494,GO:1990204	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iETEC_1333.ETEC_0111,iSSON_1240.SSON_0123,iYL1228.KPN_00119	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1701214_1	999141.GME_12469	8.88e-31	110.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,1S8U6@1236|Gammaproteobacteria,1XKH9@135619|Oceanospirillales	135619|Oceanospirillales	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
k59_1701214_2	28377.ENSACAP00000003735	5.89e-07	52.0	COG1185@1|root,KOG1067@2759|Eukaryota,39IKE@33154|Opisthokonta,3BAT8@33208|Metazoa,3CZG5@33213|Bilateria,482AY@7711|Chordata,4965I@7742|Vertebrata	33208|Metazoa	J	polyribonucleotide nucleotidyltransferase 1	PNPT1	GO:0000175,GO:0000177,GO:0000178,GO:0000957,GO:0000958,GO:0000959,GO:0000960,GO:0000962,GO:0000963,GO:0000964,GO:0000965,GO:0000966,GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005783,GO:0005789,GO:0005829,GO:0005840,GO:0005844,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006401,GO:0006402,GO:0006403,GO:0006725,GO:0006807,GO:0006810,GO:0006839,GO:0006950,GO:0006979,GO:0006996,GO:0007005,GO:0007049,GO:0007050,GO:0007346,GO:0008150,GO:0008152,GO:0008187,GO:0008266,GO:0008408,GO:0009056,GO:0009057,GO:0009653,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010033,GO:0010467,GO:0010468,GO:0010604,GO:0010605,GO:0010608,GO:0010629,GO:0012505,GO:0015931,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019219,GO:0019222,GO:0019439,GO:0022402,GO:0022607,GO:0031123,GO:0031124,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0031984,GO:0032502,GO:0032989,GO:0032990,GO:0032991,GO:0033036,GO:0033554,GO:0034046,GO:0034097,GO:0034599,GO:0034641,GO:0034655,GO:0035198,GO:0035456,GO:0035458,GO:0035927,GO:0035928,GO:0040008,GO:0042175,GO:0042221,GO:0042788,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043457,GO:0043467,GO:0043487,GO:0043488,GO:0043631,GO:0043632,GO:0043633,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0044528,GO:0045025,GO:0045786,GO:0045926,GO:0045930,GO:0045935,GO:0046483,GO:0046700,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048856,GO:0048869,GO:0050657,GO:0050658,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051029,GO:0051171,GO:0051173,GO:0051179,GO:0051234,GO:0051236,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051716,GO:0051726,GO:0055085,GO:0060255,GO:0061013,GO:0061014,GO:0061980,GO:0065003,GO:0065007,GO:0065008,GO:0070013,GO:0070206,GO:0070207,GO:0070584,GO:0070717,GO:0070887,GO:0071042,GO:0071047,GO:0071310,GO:0071345,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071850,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0090305,GO:0090342,GO:0090501,GO:0090503,GO:0090615,GO:0090616,GO:0097159,GO:0097222,GO:0098798,GO:0098827,GO:0140053,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1903311,GO:1903313,GO:1905354,GO:1990542,GO:1990904,GO:2000625,GO:2000627,GO:2000628,GO:2000630,GO:2000772	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_1756577_1	270374.MELB17_22010	1.04e-85	264.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RNPX@1236|Gammaproteobacteria,465ZH@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015399,GO:0015405,GO:0015417,GO:0015595,GO:0015606,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0015848,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0097159,GO:0097367,GO:0098533,GO:0098655,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902047,GO:1902494,GO:1902495,GO:1903711,GO:1904949,GO:1990351	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	iB21_1397.B21_01132,iECBD_1354.ECBD_2473,iECB_1328.ECB_01124,iECD_1391.ECD_01124,iECO111_1330.ECO111_1474,iECO26_1355.ECO26_1643,iEcHS_1320.EcHS_A1246,iEcolC_1368.EcolC_2477,iSBO_1134.SBO_1915,iSSON_1240.SSON_1144,iSbBS512_1146.SbBS512_E1304,iUMNK88_1353.UMNK88_1456	ABC_tran,TOBE_2
k59_581865_2	227377.CBU_1924	1.58e-32	127.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1JCX2@118969|Legionellales	118969|Legionellales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_640814_1	426716.JOAJ01000001_gene250	4.97e-53	182.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4FU7H@85025|Nocardiaceae	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1701219_1	397288.C806_04190	7.3e-13	70.5	COG0352@1|root,COG0352@2|Bacteria,1V3ZR@1239|Firmicutes,24DG3@186801|Clostridia,27MKX@186928|unclassified Lachnospiraceae	186801|Clostridia	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
k59_1165328_1	1304865.JAGF01000001_gene2899	1.26e-108	333.0	COG0366@1|root,COG0366@2|Bacteria,2GKK1@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	aml	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_20
k59_701059_1	1122212.AULO01000014_gene1219	1.84e-117	346.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1XH9U@135619|Oceanospirillales	135619|Oceanospirillales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_1756585_1	794903.OPIT5_08685	1.61e-86	263.0	COG0247@1|root,COG0247@2|Bacteria,46UD9@74201|Verrucomicrobia,3K7SD@414999|Opitutae	414999|Opitutae	C	Cysteine-rich domain	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
k59_349240_1	768671.ThimaDRAFT_1924	6.81e-61	199.0	COG0443@1|root,COG0443@2|Bacteria,1P7BK@1224|Proteobacteria,1RRN2@1236|Gammaproteobacteria,1X0BW@135613|Chromatiales	135613|Chromatiales	O	PRTRC system protein D	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1701230_1	367299.JOEE01000002_gene2282	3.73e-118	352.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FEX6@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	AMP-binding protein	fadD5	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_1756587_1	68223.JNZY01000010_gene1938	2.77e-40	141.0	COG4989@1|root,COG4989@2|Bacteria,2GM3C@201174|Actinobacteria	201174|Actinobacteria	S	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1464833_1	518766.Rmar_1178	4.68e-65	219.0	COG3591@1|root,COG3591@2|Bacteria,4NEAK@976|Bacteroidetes,1FJT8@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Peptidase S46	dpp7	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008239,GO:0009056,GO:0009279,GO:0009986,GO:0009987,GO:0016020,GO:0016049,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030154,GO:0030312,GO:0030313,GO:0031975,GO:0032502,GO:0033218,GO:0034641,GO:0040007,GO:0042277,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044462,GO:0044464,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048869,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
k59_231995_1	1317124.DW2_03019	1.69e-94	285.0	COG0725@1|root,COG0725@2|Bacteria,1NACV@1224|Proteobacteria,2U20P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
k59_581885_1	370438.PTH_1175	2.07e-97	299.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,25E48@186801|Clostridia,26111@186807|Peptococcaceae	186801|Clostridia	I	TIGRFAM acetyl-CoA carboxylase, biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_879596_2	911045.PSE_3128	2.5e-70	228.0	COG4263@1|root,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,2TTB5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide	nosZ	-	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	COX2,Cupredoxin_1
k59_1405654_1	1267005.KB911261_gene2221	1.44e-92	283.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2TQMT@28211|Alphaproteobacteria,3N6EX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_1231020_1	1042375.AFPL01000004_gene630	2.06e-48	162.0	COG2716@1|root,COG2716@2|Bacteria,1MZJ6@1224|Proteobacteria,1S39E@1236|Gammaproteobacteria,46837@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	COG2716 Glycine cleavage system regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT,ACT_4,ACT_6
k59_1464849_1	1049564.TevJSym_aq00110	1.18e-46	166.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1J4DP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378	DALR_1,tRNA_synt_2f
k59_465222_1	1026882.MAMP_01338	3.46e-162	483.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,45ZVX@72273|Thiotrichales	72273|Thiotrichales	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_701092_1	1298864.AUEQ01000001_gene4432	7.14e-81	257.0	COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria,235H5@1762|Mycobacteriaceae	201174|Actinobacteria	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_521629_1	1049564.TevJSym_au00220	1.3e-125	384.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1J4FT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_521629_2	653733.Selin_1522	1.66e-85	262.0	COG0019@1|root,COG0019@2|Bacteria	2|Bacteria	E	diaminopimelate decarboxylase activity	nspC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019842,GO:0030170,GO:0034641,GO:0036094,GO:0042401,GO:0042710,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044010,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044764,GO:0045312,GO:0046204,GO:0046983,GO:0048037,GO:0050662,GO:0051704,GO:0070279,GO:0071704,GO:0097159,GO:0097164,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.1.1.96	ko:K13747	ko00330,ko01100,map00330,map01100	-	R09081,R09082	RC00299	ko00000,ko00001,ko01000	-	-	-	Orn_DAP_Arg_deC
k59_879618_1	296591.Bpro_4805	3.19e-38	142.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2VJ2W@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_1231039_1	1249627.D779_1277	9.91e-52	181.0	COG2204@1|root,COG2204@2|Bacteria,1P98K@1224|Proteobacteria,1RTKE@1236|Gammaproteobacteria,1WWBD@135613|Chromatiales	135613|Chromatiales	T	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_4,PAS_8
k59_1405675_1	1049564.TevJSym_ad00290	6.05e-79	264.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,1J980@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2309)	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k59_1756629_1	1231185.BAMP01000008_gene2146	4.23e-98	296.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,43HJY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Belongs to the thiolase family	phbA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_465258_2	998674.ATTE01000001_gene1726	6.52e-58	184.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins	iscR	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
k59_232046_2	1283300.ATXB01000002_gene3020	2.84e-47	171.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1XEH5@135618|Methylococcales	135618|Methylococcales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_1231055_1	1121472.AQWN01000006_gene1838	8.04e-90	291.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,260ZH@186807|Peptococcaceae	186801|Clostridia	C	binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_9,NAD_binding_8,Pyr_redox_2
k59_761281_1	595593.JREV01000060_gene2546	5.05e-92	288.0	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria,1WAGD@1268|Micrococcaceae	201174|Actinobacteria	G	Alpha-amylase domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_701127_1	446469.Sked_04430	2.82e-45	156.0	COG0576@1|root,COG0576@2|Bacteria,2GP4F@201174|Actinobacteria	201174|Actinobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_701127_2	471853.Bcav_3709	6.22e-130	388.0	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria	201174|Actinobacteria	O	Heat shock 70 kDa protein	dnaK	GO:0000302,GO:0000303,GO:0000305,GO:0001968,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016310,GO:0019222,GO:0019538,GO:0019899,GO:0030112,GO:0030162,GO:0030312,GO:0030313,GO:0031323,GO:0031325,GO:0031975,GO:0031982,GO:0032268,GO:0032270,GO:0033554,GO:0034599,GO:0034614,GO:0035375,GO:0036211,GO:0040007,GO:0042221,GO:0042603,GO:0043170,GO:0043226,GO:0043227,GO:0043230,GO:0043388,GO:0043412,GO:0044044,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046677,GO:0046688,GO:0046777,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051098,GO:0051099,GO:0051101,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070613,GO:0070887,GO:0071450,GO:0071451,GO:0071704,GO:0071944,GO:0080090,GO:0097691,GO:1901564,GO:1901700,GO:1901701,GO:1903317,GO:1903319,GO:1903561,GO:2000677,GO:2000679	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_1701306_2	187272.Mlg_0924	9.15e-55	181.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1WWHV@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_1582359_1	768671.ThimaDRAFT_4037	2.47e-17	80.5	COG3385@1|root,COG3385@2|Bacteria,1RA6A@1224|Proteobacteria,1SDJ1@1236|Gammaproteobacteria,1X0RY@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_808667_2	1123073.KB899241_gene2058	9.5e-20	82.4	2EGSV@1|root,33AIZ@2|Bacteria,1NGPG@1224|Proteobacteria,1SGM3@1236|Gammaproteobacteria,1X8YC@135614|Xanthomonadales	135614|Xanthomonadales	S	Cysteine-rich CPXCG	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_CPXG
k59_349330_1	889378.Spiaf_1745	1.09e-33	125.0	COG1018@1|root,COG1018@2|Bacteria	2|Bacteria	C	nitric oxide dioxygenase activity	fpr	GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004324,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0016043,GO:0016052,GO:0016226,GO:0016491,GO:0016730,GO:0016731,GO:0019318,GO:0019320,GO:0022607,GO:0031163,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0055114,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1901575,GO:1901700	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	iECIAI39_1322.ECIAI39_3072,iEcSMS35_1347.EcSMS35_4364,iYL1228.KPN_04002	FAD_binding_6,NAD_binding_1
k59_1167344_1	1192124.LIG30_2499	3.83e-27	111.0	COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,2VJUC@28216|Betaproteobacteria,1K38E@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
k59_1055468_1	1043205.AFYF01000026_gene337	7.7e-165	469.0	COG0673@1|root,COG0673@2|Bacteria,2GJCY@201174|Actinobacteria,4FG4S@85021|Intrasporangiaceae	201174|Actinobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_1055468_2	446469.Sked_08620	2.91e-37	135.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	degT	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
k59_1466051_1	398767.Glov_2454	1.04e-34	124.0	COG4752@1|root,COG4752@2|Bacteria,1RJ2G@1224|Proteobacteria,42SXX@68525|delta/epsilon subdivisions,2WP1I@28221|Deltaproteobacteria,43TJQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	SAM-dependent RNA methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltrn_RNA_4
k59_1466051_2	545276.KB898725_gene637	5.68e-19	84.3	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,1RMWC@1236|Gammaproteobacteria,1WWK4@135613|Chromatiales	135613|Chromatiales	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
k59_1466057_1	1123401.JHYQ01000030_gene3064	3.03e-60	209.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,45ZPF@72273|Thiotrichales	72273|Thiotrichales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1232578_2	314278.NB231_13341	2.52e-32	125.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1X29W@135613|Chromatiales	135613|Chromatiales	NT	chemotaxis	-	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	MCPsignal,PilJ
k59_233624_1	177439.DP2923	5.05e-60	192.0	COG1207@1|root,COG1207@2|Bacteria,1RD3B@1224|Proteobacteria,42ZXX@68525|delta/epsilon subdivisions,2WV9N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
k59_467177_1	765913.ThidrDRAFT_2212	1.18e-28	113.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria,1WX3F@135613|Chromatiales	135613|Chromatiales	E	Belongs to the peptidase M20A family. ArgE subfamily	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_467177_2	62977.ACIAD0039	3.84e-23	98.2	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,3NIZC@468|Moraxellaceae	1236|Gammaproteobacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_2830,iLF82_1304.LF82_0116,iNRG857_1313.NRG857_13920,iYL1228.KPN_03226	AA_kinase,Acetyltransf_1
k59_1167409_1	316058.RPB_1623	1.53e-69	221.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,3JQZ0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	tdcB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006520,GO:0006563,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016841,GO:0016853,GO:0016854,GO:0016855,GO:0017144,GO:0018249,GO:0019538,GO:0019752,GO:0019842,GO:0030170,GO:0030378,GO:0030848,GO:0036094,GO:0036211,GO:0036361,GO:0042219,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046416,GO:0046437,GO:0046872,GO:0047661,GO:0048037,GO:0050662,GO:0070178,GO:0070179,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1232583_1	670307.HYPDE_30148	5.09e-151	447.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2TR86@28211|Alphaproteobacteria,3N6HP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Helicase	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_583074_1	1117647.M5M_03335	3.74e-06	53.5	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1J56R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Belongs to the peptidase S26 family	lepB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_1406839_1	1444711.CCJF01000005_gene1514	3.37e-19	92.0	COG3011@1|root,COG3011@2|Bacteria,2JGT8@204428|Chlamydiae	204428|Chlamydiae	S	Lipase maturation factor	-	-	-	-	-	-	-	-	-	-	-	-	LMF1
k59_467193_1	1122130.AUHN01000008_gene1412	1.07e-140	408.0	COG0297@1|root,COG0297@2|Bacteria,2I2EE@201174|Actinobacteria	201174|Actinobacteria	G	PFAM Glycosyl transferase, group 1	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576	2.4.1.342	ko:K16148	ko00500,ko01100,map00500,map01100	-	R02421,R11530	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
k59_642323_1	926569.ANT_12940	1.95e-65	213.0	COG0793@1|root,COG0793@2|Bacteria,2G6HR@200795|Chloroflexi	200795|Chloroflexi	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_702649_1	1429046.RR21198_5247	1.16e-99	308.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,4G5UB@85025|Nocardiaceae	201174|Actinobacteria	M	Exporter of polyketide	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_1055557_1	269796.Rru_A2660	3.49e-11	63.2	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2TQVF@28211|Alphaproteobacteria,2JQG6@204441|Rhodospirillales	204441|Rhodospirillales	L	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_1055557_2	640511.BC1002_5670	2.89e-33	128.0	COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria,1MU3V@1224|Proteobacteria,2VH3U@28216|Betaproteobacteria,1K1TG@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1232607_1	765910.MARPU_07530	3.13e-10	60.5	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1X2RK@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HAMP,HATPase_c,HisKA,Hpt,MASE1,PAS_3,PAS_9,Response_reg
k59_1232607_2	1219065.VPR01S_01_01070	1.02e-94	285.0	COG3221@1|root,COG3221@2|Bacteria,1R4SK@1224|Proteobacteria,1RR7M@1236|Gammaproteobacteria,1XUEH@135623|Vibrionales	135623|Vibrionales	P	ABC-type phosphate phosphonate transport system, periplasmic component	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
k59_1758072_1	1049564.TevJSym_ad00500	3.58e-209	598.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,1J4RJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CP	Proton-conducting membrane transporter	phaD	-	1.6.5.3	ko:K00342,ko:K05561,ko:K05568	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M
k59_1758072_2	768671.ThimaDRAFT_1746	3.23e-77	249.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,1WX59@135613|Chromatiales	135613|Chromatiales	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_1640669_1	1121895.Q765_06785	1.84e-11	70.5	COG1572@1|root,COG1572@2|Bacteria,4NDY7@976|Bacteroidetes,1HYJD@117743|Flavobacteriia,2NS7F@237|Flavobacterium	976|Bacteroidetes	S	Peptidase C25	porU	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C25
k59_762936_1	517722.AEUE01000001_gene2850	8.55e-49	176.0	COG1629@1|root,COG4771@2|Bacteria,1QYDM@1224|Proteobacteria,2TXPM@28211|Alphaproteobacteria,2K1U8@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_175854_1	1232410.KI421413_gene659	4.95e-37	128.0	2DN2Z@1|root,32V89@2|Bacteria,1N3VG@1224|Proteobacteria,42TI7@68525|delta/epsilon subdivisions,2WQNX@28221|Deltaproteobacteria,43SPU@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-ribbon_3
k59_1055597_1	768671.ThimaDRAFT_0247	2.05e-53	177.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1WXIX@135613|Chromatiales	135613|Chromatiales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1055597_2	768671.ThimaDRAFT_0248	2.39e-25	102.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1WWFA@135613|Chromatiales	135613|Chromatiales	E	PFAM Prephenate dehydratase	-	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
k59_702682_1	748658.KB907313_gene2379	4.61e-70	224.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,1WX3R@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
k59_943534_1	90814.KL370891_gene275	1.64e-09	58.5	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,45ZN3@72273|Thiotrichales	72273|Thiotrichales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_943534_2	522306.CAP2UW1_0606	3.96e-11	67.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2VHQP@28216|Betaproteobacteria,1KQUB@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	HlyD_D23
k59_1059730_1	864069.MicloDRAFT_00049370	7.27e-15	73.2	COG2235@1|root,COG2235@2|Bacteria,1NCGV@1224|Proteobacteria,2TU0Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Arginine	arcA	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
k59_589850_1	1380354.JIAN01000005_gene1271	1.68e-126	402.0	COG0392@1|root,COG0392@2|Bacteria,2GMAV@201174|Actinobacteria,4F0KN@85016|Cellulomonadaceae	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
k59_1763685_2	1499967.BAYZ01000167_gene6742	1.54e-39	145.0	COG0747@1|root,COG0747@2|Bacteria	2|Bacteria	E	dipeptide transport	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_824335_2	768671.ThimaDRAFT_2344	3.87e-72	237.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1WW1J@135613|Chromatiales	135613|Chromatiales	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	-	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_1235574_1	663932.KB902575_gene2340	1.51e-46	170.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,2JQC9@204441|Rhodospirillales	204441|Rhodospirillales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_472349_1	502025.Hoch_5783	1.61e-68	220.0	COG2170@1|root,COG2170@2|Bacteria,1MY35@1224|Proteobacteria,42PBG@68525|delta/epsilon subdivisions,2WK4S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Glutamate-cysteine ligase	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
k59_472349_2	1517416.IDAT_09080	7.47e-26	107.0	COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,1RNXP@1236|Gammaproteobacteria,2QF7V@267893|Idiomarinaceae	1236|Gammaproteobacteria	HJ	RimK-like ATPgrasp N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Dala_Dala_lig_C,RLAN,RimK
k59_356431_1	1134474.O59_003420	9.99e-58	200.0	COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,1RNET@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Receptor	oprC	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1000488_1	379066.GAU_2391	1.94e-139	409.0	COG1008@1|root,COG1008@2|Bacteria,1ZUBB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1705189_1	1249627.D779_4097	8.7e-42	154.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales	135613|Chromatiales	D	DNA segregation ATPase FtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1705189_2	1049564.TevJSym_ah00170	5.34e-78	244.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria,1J4WY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_296337_1	345341.KUTG_06687	1.72e-84	273.0	COG0541@1|root,COG1228@1|root,COG0541@2|Bacteria,COG1228@2|Bacteria,2GK4R@201174|Actinobacteria,4DXH6@85010|Pseudonocardiales	201174|Actinobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_1295773_1	204773.HEAR2685	8.02e-44	159.0	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VHA3@28216|Betaproteobacteria,476F3@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_943556_1	765913.ThidrDRAFT_3339	2.48e-53	171.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,1WY23@135613|Chromatiales	135613|Chromatiales	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
k59_943556_2	765912.Thimo_1325	2.27e-15	73.9	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria,1WXHT@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
k59_296341_1	446469.Sked_16240	3.76e-64	217.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria	201174|Actinobacteria	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	ctpE	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	-	ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.23	-	-	E1-E2_ATPase,Hydrolase
k59_1528882_1	471853.Bcav_1597	4.73e-117	353.0	COG0611@1|root,COG0611@2|Bacteria,2GP6E@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	GO:0008150,GO:0040007	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2977c	AIRS,AIRS_C
k59_120236_1	643562.Daes_1238	1.11e-223	634.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,42MGF@68525|delta/epsilon subdivisions,2WJMB@28221|Deltaproteobacteria,2M9H9@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM Carboxylyase-related protein	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_1176883_2	1123393.KB891328_gene696	1.78e-94	282.0	COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,2VHEK@28216|Betaproteobacteria,1KT8R@119069|Hydrogenophilales	119069|Hydrogenophilales	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_766526_3	1407650.BAUB01000003_gene753	9.96e-58	186.0	COG1741@1|root,COG1741@2|Bacteria,1G0UH@1117|Cyanobacteria,1GYC7@1129|Synechococcus	1117|Cyanobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
k59_1354028_1	768671.ThimaDRAFT_0602	1.08e-102	330.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW08@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_532247_1	1519464.HY22_10905	1.93e-50	168.0	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_532247_2	1323663.AROI01000002_gene1088	0.000516	41.6	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_1001414_1	1304865.JAGF01000001_gene2651	7.5e-61	198.0	COG1300@1|root,COG1300@2|Bacteria,2GJTG@201174|Actinobacteria,4F0H8@85016|Cellulomonadaceae	201174|Actinobacteria	S	Stage II sporulation protein M	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIM
k59_1001414_2	1713.JOFV01000002_gene551	4.08e-60	196.0	COG1714@1|root,COG1714@2|Bacteria,2H4MP@201174|Actinobacteria,4F14C@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM RDD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	RDD
k59_5149_1	1147.D082_28360	3.34e-64	207.0	COG0179@1|root,COG0179@2|Bacteria,1G06Y@1117|Cyanobacteria,1H5AP@1142|Synechocystis	1117|Cyanobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	hpcE	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
k59_1177910_1	1121957.ATVL01000012_gene785	1.51e-17	80.1	COG0796@1|root,COG0796@2|Bacteria,4NG1C@976|Bacteroidetes,47MMI@768503|Cytophagia	976|Bacteroidetes	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
k59_1177910_2	1168034.FH5T_21925	1.75e-18	82.4	COG2825@1|root,COG2825@2|Bacteria,4NSCM@976|Bacteroidetes,2FU10@200643|Bacteroidia	976|Bacteroidetes	M	Outer membrane protein (OmpH-like)	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
k59_1764693_1	314265.R2601_12448	0.000101	50.1	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2TR03@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_297532_2	981384.AEYW01000028_gene4248	1.19e-50	176.0	2F138@1|root,33U4R@2|Bacteria,1NUMP@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1529949_1	1163617.SCD_n02608	1.82e-45	159.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2VIZB@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	ko:K11102	-	-	-	-	ko00000,ko02000	2.A.23.1.1,2.A.23.1.2	-	-	SDF
k59_1529949_2	765912.Thimo_1969	1.35e-23	94.7	2AU8I@1|root,31JVR@2|Bacteria,1RJF3@1224|Proteobacteria,1S7F1@1236|Gammaproteobacteria,1WYJ3@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1529949_3	765913.ThidrDRAFT_4078	1.42e-09	58.5	COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,1WWKI@135613|Chromatiales	135613|Chromatiales	G	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane	lapB	-	-	ko:K19804	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_7
k59_945303_1	2340.JV46_02880	1.36e-119	351.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,1J8CF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iE2348C_1286.E2348C_2469,iEC55989_1330.EC55989_2573,iECO103_1326.ECO103_2794,iECO111_1330.ECO111_3077,iECO26_1355.ECO26_3317,iECSE_1348.ECSE_2638,iECW_1372.ECW_m2518,iEKO11_1354.EKO11_1436,iSSON_1240.SSON_2387,iUMNK88_1353.UMNK88_2882,iWFL_1372.ECW_m2518	Chorismate_synt
k59_179952_1	1045009.AFXQ01000039_gene2975	1.77e-16	82.4	2E4AX@1|root,32Z6K@2|Bacteria,2HT79@201174|Actinobacteria,1W9JM@1268|Micrococcaceae	201174|Actinobacteria	S	Domain of unknown function (DUF2017)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2017
k59_179952_2	1171373.PACID_23910	0.000282	41.2	COG2127@1|root,COG2127@2|Bacteria,2IQ3Z@201174|Actinobacteria	201174|Actinobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
k59_414565_2	443143.GM18_2215	3.66e-60	196.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,42MB0@68525|delta/epsilon subdivisions,2WJ42@28221|Deltaproteobacteria,43TP6@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_1415	Phe_tRNA-synt_N,tRNA-synt_2d
k59_1412814_2	1385515.N791_09490	1.97e-21	87.4	COG2212@1|root,COG2212@2|Bacteria,1N8WJ@1224|Proteobacteria,1S8ZM@1236|Gammaproteobacteria,1X7NA@135614|Xanthomonadales	135614|Xanthomonadales	P	Multisubunit Na H antiporter, MnhF subunit	phaF	-	-	ko:K05563	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	MrpF_PhaF
k59_1412814_3	52598.EE36_14397	2.74e-15	72.4	COG1863@1|root,COG1863@2|Bacteria,1RH9F@1224|Proteobacteria,2VGED@28211|Alphaproteobacteria,3ZX9I@60136|Sulfitobacter	28211|Alphaproteobacteria	P	Na+/H+ ion antiporter subunit	-	-	-	ko:K05562	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	MNHE
k59_886506_2	247633.GP2143_16561	2.45e-51	166.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,1J6D5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	GO:0001505,GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0017144,GO:0019464,GO:0019752,GO:0031405,GO:0031406,GO:0033293,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901681	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	iE2348C_1286.E2348C_3156,iPC815.YPO0906	GCV_H
k59_708393_1	1173263.Syn7502_01644	9.56e-05	53.1	COG0419@1|root,COG0419@2|Bacteria,1G26D@1117|Cyanobacteria,1GZJJ@1129|Synechococcus	1117|Cyanobacteria	L	ATPase involved in DNA repair	sbcC	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_15,AAA_23,Rad50_zn_hook,SbcCD_C
k59_1706338_1	1267005.KB911257_gene1091	5.15e-111	327.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TSV6@28211|Alphaproteobacteria,3N6B6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
k59_886521_1	472759.Nhal_3534	6.44e-100	308.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1WXKA@135613|Chromatiales	135613|Chromatiales	G	PFAM Alpha amylase, catalytic	-	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_1825663_1	314278.NB231_07482	6.9e-114	346.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1WW7H@135613|Chromatiales	135613|Chromatiales	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1236777_1	590998.Celf_2846	7.52e-180	517.0	COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4F0F9@85016|Cellulomonadaceae	201174|Actinobacteria	I	PFAM Carbamoyl-phosphate synthase L chain	bccA	-	6.3.4.14,6.4.1.2,6.4.1.3	ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04385	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_1354075_1	1049564.TevJSym_aa01650	8.86e-90	277.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1J4KT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_1118832_1	429009.Adeg_1885	9.69e-41	154.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,42FJG@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
k59_473490_1	1123065.ATWL01000003_gene830	8.47e-178	504.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_64710_1	391735.Veis_1947	3.85e-32	119.0	28M46@1|root,2ZAI5@2|Bacteria,1R68K@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_64710_2	323261.Noc_1367	1.62e-109	338.0	COG1743@1|root,COG1743@2|Bacteria,1P7I6@1224|Proteobacteria,1RY2K@1236|Gammaproteobacteria,1WXME@135613|Chromatiales	135613|Chromatiales	L	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31,N6_N4_Mtase
k59_649677_2	1121447.JONL01000001_gene1002	5.49e-33	119.0	COG1853@1|root,COG1853@2|Bacteria,1RBSR@1224|Proteobacteria,42R0G@68525|delta/epsilon subdivisions,2WMYE@28221|Deltaproteobacteria,2MAM7@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM flavin reductase domain protein FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
k59_591100_2	768671.ThimaDRAFT_4410	1.67e-196	574.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,1WW7D@135613|Chromatiales	135613|Chromatiales	C	Molybdopterin oxidoreductase Fe4S4 domain	napA	-	-	ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_239134_1	219305.MCAG_02534	7.74e-128	368.0	COG0842@1|root,COG0842@2|Bacteria,2GIVW@201174|Actinobacteria,4DAHH@85008|Micromonosporales	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_1297613_1	1049564.TevJSym_an00490	1.08e-136	392.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,1J4DJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_766588_1	1049564.TevJSym_ar00030	1.45e-42	148.0	COG1977@1|root,COG3536@1|root,COG1977@2|Bacteria,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,1S8TB@1236|Gammaproteobacteria,1J6I8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	protein conserved in bacteria	-	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF971
k59_1825703_1	448385.sce6597	1.73e-21	93.2	2E5WH@1|root,330KI@2|Bacteria,1QAVR@1224|Proteobacteria,435BU@68525|delta/epsilon subdivisions,2WZPC@28221|Deltaproteobacteria,2Z2GK@29|Myxococcales	28221|Deltaproteobacteria	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
k59_1236797_1	1232410.KI421425_gene1550	7.56e-35	135.0	COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,42Z0Q@68525|delta/epsilon subdivisions,2WU0G@28221|Deltaproteobacteria,43T6R@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1588585_1	1297742.A176_06441	2.4e-44	159.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,4345U@68525|delta/epsilon subdivisions,2X20T@28221|Deltaproteobacteria,2YVEZ@29|Myxococcales	28221|Deltaproteobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS
k59_1236799_1	1123228.AUIH01000019_gene3690	0.000113	43.1	COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1XHBT@135619|Oceanospirillales	135619|Oceanospirillales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_1236799_2	2340.JV46_06490	4.45e-19	86.3	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1J4F3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_239149_1	857087.Metme_3422	8.6e-13	68.6	COG0600@1|root,COG0600@2|Bacteria,1MU6Q@1224|Proteobacteria,1RPP1@1236|Gammaproteobacteria,1XE8H@135618|Methylococcales	135618|Methylococcales	P	PFAM Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K15577	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	BPD_transp_1
k59_239149_2	1120970.AUBZ01000019_gene3563	9.55e-81	253.0	COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RPUP@1236|Gammaproteobacteria,465AR@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components	nrtC	-	-	ko:K15576	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	NMT1_2
k59_1001474_1	765911.Thivi_4457	2.42e-22	100.0	COG4902@1|root,COG4902@2|Bacteria,1RHUF@1224|Proteobacteria,1S5D0@1236|Gammaproteobacteria,1WYC7@135613|Chromatiales	135613|Chromatiales	S	protein domain (DUF2202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2202
k59_1588588_1	546273.VEIDISOL_01891	7.36e-16	82.4	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,4H20Y@909932|Negativicutes	909932|Negativicutes	D	Belongs to the SEDS family	spoVE	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_532318_1	96561.Dole_0073	1.35e-17	80.9	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,42M2W@68525|delta/epsilon subdivisions,2WJBV@28221|Deltaproteobacteria,2MJ9I@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,CoA_binding,Ligase_CoA
k59_886567_1	1249627.D779_4097	1.09e-134	407.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales	135613|Chromatiales	D	DNA segregation ATPase FtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1061000_1	367299.JOEE01000011_gene3144	5.1e-93	285.0	COG2723@1|root,COG2723@2|Bacteria,2GJAF@201174|Actinobacteria,4FE4U@85021|Intrasporangiaceae	201174|Actinobacteria	G	Beta-glucosidase	bglA	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
k59_1061000_2	367299.JOEE01000011_gene3143	8.29e-55	182.0	COG0579@1|root,COG0579@2|Bacteria,2GKFB@201174|Actinobacteria,4FFHP@85021|Intrasporangiaceae	201174|Actinobacteria	S	Catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate	-	-	-	ko:K15736	-	-	-	-	ko00000,ko01000	-	-	-	DAO
k59_1530021_1	502025.Hoch_5389	5.11e-43	157.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,42PV9@68525|delta/epsilon subdivisions,2WKF2@28221|Deltaproteobacteria,2YWP2@29|Myxococcales	28221|Deltaproteobacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	clsA	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
k59_64761_1	765911.Thivi_2766	2.98e-75	251.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1001480_1	1279019.ARQK01000052_gene1444	2.14e-44	147.0	28PZA@1|root,2ZCIS@2|Bacteria,1RCMD@1224|Proteobacteria,1SEW0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_955869_2	1304865.JAGF01000001_gene1067	3.99e-41	144.0	COG2375@1|root,COG2375@2|Bacteria,2GK5X@201174|Actinobacteria,4F2KY@85016|Cellulomonadaceae	201174|Actinobacteria	P	Siderophore-interacting protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_9,SIP
k59_716098_1	593907.Celgi_1595	1e-105	322.0	COG0173@1|root,COG0173@2|Bacteria,2GJHU@201174|Actinobacteria,4F0IP@85016|Cellulomonadaceae	201174|Actinobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_1185965_1	1121439.dsat_2181	1.32e-29	113.0	COG2048@1|root,COG2048@2|Bacteria,1RC7G@1224|Proteobacteria,43B85@68525|delta/epsilon subdivisions,2WMVG@28221|Deltaproteobacteria,2MBMN@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_1185965_2	439235.Dalk_5066	7.49e-19	86.3	COG0247@1|root,COG1150@1|root,COG2181@1|root,COG0247@2|Bacteria,COG1150@2|Bacteria,COG2181@2|Bacteria,1R44N@1224|Proteobacteria,42NTE@68525|delta/epsilon subdivisions,2WJN8@28221|Deltaproteobacteria,2MJEV@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Nitrate reductase gamma subunit	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_17,Fer4_8,Nitrate_red_gam
k59_253086_1	471853.Bcav_1848	2.77e-100	309.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2GK2C@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_833305_1	1366050.N234_34985	4.51e-10	57.4	2E6EG@1|root,3311Y@2|Bacteria,1NE8A@1224|Proteobacteria,2VWIK@28216|Betaproteobacteria,1KEW3@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_YMGG
k59_833305_3	765911.Thivi_3663	6.28e-74	229.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1WXCM@135613|Chromatiales	135613|Chromatiales	S	PFAM Polyphosphate kinase 2	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
k59_129147_1	765911.Thivi_2590	8.96e-38	131.0	COG1047@1|root,COG1047@2|Bacteria,1RH9C@1224|Proteobacteria,1S63R@1236|Gammaproteobacteria,1X2G4@135613|Chromatiales	135613|Chromatiales	O	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
k59_1007612_1	1121918.ARWE01000001_gene653	4.3e-45	148.0	COG1917@1|root,COG1917@2|Bacteria,1N2JS@1224|Proteobacteria,42TR3@68525|delta/epsilon subdivisions,2WQ4M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_1007612_2	396588.Tgr7_0377	2.13e-34	123.0	COG2143@1|root,COG2143@2|Bacteria,1N6H1@1224|Proteobacteria,1SQSZ@1236|Gammaproteobacteria,1X16R@135613|Chromatiales	135613|Chromatiales	O	Protein of unknown function, DUF255	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_75132_2	983917.RGE_07200	6.64e-21	86.3	COG2010@1|root,COG2010@2|Bacteria,1RDSI@1224|Proteobacteria,2VQ50@28216|Betaproteobacteria,1KKR7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome c	norC	-	-	ko:K02305	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002	3.D.4.10	-	-	Cytochrom_C
k59_480861_1	2340.JV46_10310	5.83e-57	184.0	COG3439@1|root,COG3439@2|Bacteria,1REDZ@1224|Proteobacteria,1RPW4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_955885_1	471853.Bcav_2458	1.44e-71	232.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria	201174|Actinobacteria	M	Capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
k59_1595615_1	1485545.JQLW01000007_gene711	6.01e-186	527.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria	1224|Proteobacteria	C	Nitric oxide reductase	-	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
k59_1185977_1	251221.35214645	3.98e-52	177.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
k59_896888_1	1191523.MROS_0712	1.59e-73	248.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria	2|Bacteria	E	L-glutamate biosynthetic process	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1420934_1	765912.Thimo_0054	2.72e-47	174.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1WVZW@135613|Chromatiales	135613|Chromatiales	NU	Type II and III secretion system protein	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_955892_1	1049564.TevJSym_ag01030	1.29e-49	171.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1J5DY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
k59_1836253_1	1197906.CAJQ02000029_gene3918	6.51e-29	114.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,2TR6W@28211|Alphaproteobacteria,3JTQ0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_1836253_2	991905.SL003B_4183	1e-12	64.7	COG4530@1|root,COG4530@2|Bacteria,1N85Z@1224|Proteobacteria,2UF7V@28211|Alphaproteobacteria,4BR3U@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (FYDLN_acid)	MA20_24185	-	-	-	-	-	-	-	-	-	-	-	FYDLN_acid
k59_1771732_1	1125973.JNLC01000010_gene1797	8.49e-42	149.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2TT6H@28211|Alphaproteobacteria,3JSB3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_833313_1	519989.ECTPHS_06082	8.32e-55	172.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,1WYJ2@135613|Chromatiales	135613|Chromatiales	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
k59_833313_2	323261.Noc_2921	1.9e-211	598.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1WWXH@135613|Chromatiales	135613|Chromatiales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_716111_1	765912.Thimo_1958	2.22e-50	166.0	COG1179@1|root,COG1179@2|Bacteria,1MWXR@1224|Proteobacteria,1RMT3@1236|Gammaproteobacteria,1WXXZ@135613|Chromatiales	135613|Chromatiales	H	PFAM UBA THIF-type NAD FAD binding	-	-	-	ko:K22132	-	-	-	-	ko00000,ko03016	-	-	-	ThiF
k59_716111_2	768671.ThimaDRAFT_0322	3.16e-26	107.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria,1WX2T@135613|Chromatiales	135613|Chromatiales	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	-	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_1071576_1	340177.Cag_0616	6.92e-08	61.2	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Big_3_2,CHU_C,Flg_new,LRR_5
k59_1247091_1	1713.JOFV01000010_gene1221	2.13e-90	270.0	COG0087@1|root,COG0087@2|Bacteria,2GJXT@201174|Actinobacteria,4F22C@85016|Cellulomonadaceae	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_896910_1	1045009.AFXQ01000007_gene2958	6.97e-146	418.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria,1W8IR@1268|Micrococcaceae	201174|Actinobacteria	P	Belongs to the bacterial solute-binding protein 9 family	mntC	-	-	ko:K09818,ko:K11601	ko02010,ko02020,map02010,map02020	M00243,M00316	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.1	-	-	ZnuA
k59_19532_2	768710.DesyoDRAFT_2175	1.57e-15	76.6	COG1030@1|root,COG1030@2|Bacteria,1TR54@1239|Firmicutes,247N5@186801|Clostridia,262N7@186807|Peptococcaceae	186801|Clostridia	O	Membrane-bound serine protease (ClpP class)	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
k59_657496_1	323261.Noc_2639	1.22e-35	131.0	COG3568@1|root,COG3568@2|Bacteria,1RBWV@1224|Proteobacteria,1S296@1236|Gammaproteobacteria,1X2D7@135613|Chromatiales	135613|Chromatiales	L	Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_657496_2	765912.Thimo_0446	2.92e-13	67.0	29QAQ@1|root,30B9W@2|Bacteria,1RGQ5@1224|Proteobacteria,1S5E4@1236|Gammaproteobacteria,1WY7X@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_598075_1	572477.Alvin_1131	1.57e-108	325.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1WWW0@135613|Chromatiales	135613|Chromatiales	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
k59_187875_1	686340.Metal_3671	1.15e-46	162.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1XE0U@135618|Methylococcales	135618|Methylococcales	E	Belongs to the peptidase M24B family	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_187875_2	290398.Csal_0536	1.84e-09	58.5	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,1XI0W@135619|Oceanospirillales	135619|Oceanospirillales	E	Aminotransferase class I and II	-	-	2.6.1.84,2.6.1.88	ko:K12252,ko:K14287	ko00330,ko01100,map00330,map01100	-	R08197,R08618	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1482168_1	1304865.JAGF01000001_gene1449	1.89e-45	166.0	COG0247@1|root,COG0247@2|Bacteria,2GJ7M@201174|Actinobacteria	201174|Actinobacteria	C	Fe-S oxidoreductase	fadF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_1071621_1	305700.B447_05228	2.69e-117	342.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2VI8V@28216|Betaproteobacteria,2KUV5@206389|Rhodocyclales	206389|Rhodocyclales	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_539742_2	1249627.D779_0807	1.35e-47	155.0	COG0432@1|root,COG0432@2|Bacteria,1RIKJ@1224|Proteobacteria,1S8QM@1236|Gammaproteobacteria,1WYII@135613|Chromatiales	135613|Chromatiales	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
k59_19562_1	367299.JOEE01000003_gene2770	1.16e-59	188.0	COG0740@1|root,COG0740@2|Bacteria,2GK5C@201174|Actinobacteria,4FEPP@85021|Intrasporangiaceae	201174|Actinobacteria	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP1	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
k59_19562_2	1172188.KB911834_gene4153	3.53e-05	45.8	COG2807@1|root,COG2807@2|Bacteria,2I2KJ@201174|Actinobacteria,4FEPG@85021|Intrasporangiaceae	201174|Actinobacteria	P	membrane	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_1836302_1	1121921.KB898708_gene1521	1.25e-87	278.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,2PMV1@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	G	Alpha amylase, C-terminal all-beta domain	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:1901576	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	iAPECO1_1312.APECO1_3025,iECNA114_1301.ECNA114_3542,iECOK1_1307.ECOK1_3857,iECS88_1305.ECS88_3830,iECSF_1327.ECSF_3253,iLF82_1304.LF82_0837,iNRG857_1313.NRG857_17030,iUTI89_1310.UTI89_C3941	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_1482177_1	1163409.UUA_10576	2.02e-11	63.2	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1X38I@135614|Xanthomonadales	135614|Xanthomonadales	V	Transport permease protein	yadH	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_1482177_2	251229.Chro_4000	1.05e-48	163.0	COG2135@1|root,COG2135@2|Bacteria,1G1SA@1117|Cyanobacteria,3VK4S@52604|Pleurocapsales	1117|Cyanobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
k59_253196_1	713586.KB900536_gene433	4.96e-35	125.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1WVXA@135613|Chromatiales	135613|Chromatiales	K	Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins	-	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
k59_657512_1	236097.ADG881_3302	7.26e-67	211.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,1RMWC@1236|Gammaproteobacteria,1XHIU@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
k59_1361280_1	1267005.KB911256_gene1870	2.48e-76	252.0	COG2352@1|root,COG2352@2|Bacteria	2|Bacteria	C	phosphoenolpyruvate carboxylase activity	-	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_368711_1	983917.RGE_36520	2.36e-76	242.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2VJNS@28216|Betaproteobacteria,1KJXY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904	2.7.7.7	ko:K02346,ko:K03502	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k59_955950_1	1122194.AUHU01000005_gene876	2.54e-73	231.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,46D47@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	ybhF	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_716145_1	351348.Maqu_0490	3.11e-124	367.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,4644I@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_1771776_1	446469.Sked_31600	7.54e-59	201.0	COG3387@1|root,COG3387@2|Bacteria,2ICV9@201174|Actinobacteria	201174|Actinobacteria	G	Glycoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_716148_1	396588.Tgr7_3246	2.2e-36	138.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1WX2G@135613|Chromatiales	135613|Chromatiales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
k59_1482194_1	880072.Desac_1249	3.83e-82	253.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42M19@68525|delta/epsilon subdivisions,2WK9A@28221|Deltaproteobacteria,2MRDT@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_896955_1	765910.MARPU_05545	6.99e-06	47.8	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1WW51@135613|Chromatiales	135613|Chromatiales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_253216_1	471853.Bcav_3179	2.5e-93	289.0	COG0477@1|root,COG2814@2|Bacteria,2H8PB@201174|Actinobacteria	201174|Actinobacteria	EGP	Pfam Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1008321_2	110319.CF8_3498	1.04e-74	238.0	COG2124@1|root,COG2124@2|Bacteria,2GK4Z@201174|Actinobacteria,4DN2H@85009|Propionibacteriales	201174|Actinobacteria	Q	Cytochrome P450	cyp135A1	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0016125,GO:0016491,GO:0030312,GO:0044238,GO:0044464,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901615	-	-	-	-	-	-	-	-	-	-	p450
k59_305556_1	1127696.HMPREF9134_00959	8.09e-47	164.0	COG1013@1|root,COG1013@2|Bacteria,4NIE0@976|Bacteroidetes,2FME7@200643|Bacteroidia,22VVU@171551|Porphyromonadaceae	976|Bacteroidetes	C	ferredoxin oxidoreductase subunit beta	oorB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_598869_1	1442599.JAAN01000010_gene291	1.23e-52	185.0	COG3540@1|root,COG3540@2|Bacteria,1MWAF@1224|Proteobacteria,1RNY4@1236|Gammaproteobacteria,1X50C@135614|Xanthomonadales	135614|Xanthomonadales	P	PhoD-like phosphatase, N-terminal domain	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD,PhoD_N
k59_76317_1	1121937.AUHJ01000003_gene3099	3.03e-05	43.5	COG3436@1|root,COG3436@2|Bacteria,1RHJ1@1224|Proteobacteria,1S5UN@1236|Gammaproteobacteria,467TX@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k59_76317_2	1122201.AUAZ01000006_gene4034	2.74e-20	86.3	COG2963@1|root,COG2963@2|Bacteria,1N7SX@1224|Proteobacteria,1SGP7@1236|Gammaproteobacteria,469AI@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1248311_1	1459636.NTE_01390	4.11e-30	118.0	COG0639@1|root,arCOG01143@2157|Archaea	2157|Archaea	T	COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases	-	-	3.1.3.16	ko:K01090,ko:K06269	ko03015,ko04022,ko04024,ko04113,ko04114,ko04218,ko04261,ko04270,ko04390,ko04510,ko04611,ko04720,ko04728,ko04750,ko04810,ko04910,ko04921,ko04931,ko05031,ko05034,ko05168,ko05205,map03015,map04022,map04024,map04113,map04114,map04218,map04261,map04270,map04390,map04510,map04611,map04720,map04728,map04750,map04810,map04910,map04921,map04931,map05031,map05034,map05168,map05205	-	-	-	ko00000,ko00001,ko01000,ko01009,ko03019,ko03021,ko03041	-	-	-	Metallophos
k59_1714114_1	471853.Bcav_3068	7.2e-158	450.0	COG0533@1|root,COG0533@2|Bacteria,2GJ98@201174|Actinobacteria	201174|Actinobacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
k59_1421800_1	478741.JAFS01000002_gene564	2.35e-91	282.0	COG0104@1|root,COG0104@2|Bacteria,46TDF@74201|Verrucomicrobia,37GDA@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_773410_1	367299.JOEE01000002_gene2608	1.24e-108	327.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4FET4@85021|Intrasporangiaceae	201174|Actinobacteria	T	Serine threonine protein phosphatase	pstP	GO:0000287,GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010563,GO:0010605,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0030145,GO:0030312,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0033673,GO:0036211,GO:0042325,GO:0042326,GO:0042578,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043392,GO:0043412,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0045859,GO:0045936,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051098,GO:0051100,GO:0051101,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
k59_898104_1	396588.Tgr7_2190	4.65e-61	189.0	COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,1S5ZA@1236|Gammaproteobacteria,1WYFA@135613|Chromatiales	135613|Chromatiales	P	part of a sulfur-relay system	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_898104_2	1244869.H261_12614	4.6e-13	67.8	COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,2VE5A@28211|Alphaproteobacteria,2JV2E@204441|Rhodospirillales	204441|Rhodospirillales	C	Nitrate reductase gamma subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_gam
k59_716997_1	870187.Thini_0653	4.3e-52	170.0	COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,4604J@72273|Thiotrichales	72273|Thiotrichales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
k59_1483375_1	1713.JOFV01000008_gene3275	1.31e-199	578.0	COG2609@1|root,COG2609@2|Bacteria,2GJRE@201174|Actinobacteria,4F0W9@85016|Cellulomonadaceae	201174|Actinobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0004739,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016624,GO:0016903,GO:0030312,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046872,GO:0055114,GO:0071944,GO:1902494,GO:1990204	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_1248332_1	1049564.TevJSym_be00270	6.11e-61	209.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1J57P@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the peptidase S41A family	prc	GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	BAGE,DUF3340,PDZ,Peptidase_S41
k59_1309269_1	590998.Celf_1176	3.87e-30	114.0	COG1451@1|root,COG1451@2|Bacteria,2GMP6@201174|Actinobacteria,4F1PC@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
k59_1772611_1	228410.NE1158	5.54e-69	214.0	COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,2VQ39@28216|Betaproteobacteria,372JP@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Nudix hydrolase	nudC_1	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N_2
k59_369868_1	382464.ABSI01000011_gene3151	5.3e-26	112.0	COG1757@1|root,COG1757@2|Bacteria,46UU8@74201|Verrucomicrobia,2IVTE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Na+/H+ antiporter family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
k59_834182_2	471853.Bcav_0887	1.91e-21	92.0	COG1834@1|root,COG1834@2|Bacteria,2GNTN@201174|Actinobacteria	201174|Actinobacteria	E	amidinotransferase	-	GO:0003674,GO:0003824,GO:0016403,GO:0016787,GO:0016810,GO:0016813	-	-	-	-	-	-	-	-	-	-	Amidinotransf
k59_130080_1	870187.Thini_0160	6.41e-12	63.9	2E4VX@1|root,32ZQ3@2|Bacteria,1N8IC@1224|Proteobacteria,1SC7W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3144)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3144
k59_130080_2	1244869.H261_09252	3.63e-09	58.5	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,1MXK5@1224|Proteobacteria,2U13I@28211|Alphaproteobacteria,2JQVM@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
k59_773424_1	590998.Celf_2330	2.3e-91	275.0	COG0020@1|root,COG0020@2|Bacteria,2GIXF@201174|Actinobacteria,4F101@85016|Cellulomonadaceae	201174|Actinobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.86,2.5.1.88	ko:K00806,ko:K14215,ko:K21273	ko00900,ko01110,map00900,map01110	-	R06447,R09244,R09731	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_773424_2	471853.Bcav_1771	1.31e-35	127.0	COG0586@1|root,COG0586@2|Bacteria,2GSDF@201174|Actinobacteria	201174|Actinobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_1596589_1	1283300.ATXB01000001_gene601	1.79e-07	50.8	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,1RMW0@1236|Gammaproteobacteria,1XEQN@135618|Methylococcales	135618|Methylococcales	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
k59_1317080_2	95619.PM1_0205585	4.76e-46	150.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,1S5VB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
k59_905915_1	933262.AXAM01000063_gene620	8.23e-128	372.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MIA8@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1490209_1	349124.Hhal_0487	3.18e-111	331.0	COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,1RQ8M@1236|Gammaproteobacteria,1WWMX@135613|Chromatiales	135613|Chromatiales	N	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	-	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
k59_377666_2	1049564.TevJSym_ag00220	6.93e-52	176.0	COG4651@1|root,COG4651@2|Bacteria,1QUQS@1224|Proteobacteria,1T21E@1236|Gammaproteobacteria,1J57I@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Kef-type K transport	kefC_1	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1543654_1	331869.BAL199_12636	1.05e-100	304.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1662277_1	935839.JAGJ01000007_gene3075	4.28e-98	318.0	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4F3XT@85017|Promicromonosporaceae	201174|Actinobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_1317101_1	322710.Avin_41510	9.1e-63	202.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_1304	GHMP_kinases_C,GHMP_kinases_N
k59_262106_1	1150469.RSPPHO_01578	3.24e-20	91.3	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TR2Z@28211|Alphaproteobacteria,2JQ2N@204441|Rhodospirillales	204441|Rhodospirillales	C	FAD linked oxidases, C-terminal domain	-	-	1.1.2.4	ko:K00102	ko00620,map00620	-	R00197	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_262106_2	1136417.AZWE01000014_gene1668	7.04e-12	68.2	COG2807@1|root,COG2807@2|Bacteria,2I37C@201174|Actinobacteria	201174|Actinobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1427394_1	933262.AXAM01000008_gene1932	1.07e-71	231.0	COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,42MU7@68525|delta/epsilon subdivisions,2WJFQ@28221|Deltaproteobacteria,2MIIC@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
k59_777990_2	335543.Sfum_0949	4.47e-13	73.2	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42PPF@68525|delta/epsilon subdivisions,2WM3K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_487239_1	298655.KI912266_gene3829	8.74e-66	231.0	COG1132@1|root,COG1132@2|Bacteria,2GJYK@201174|Actinobacteria,4EU6N@85013|Frankiales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_tran
k59_663897_1	335543.Sfum_2413	9.63e-34	135.0	COG3523@1|root,COG3523@2|Bacteria,1NRHK@1224|Proteobacteria,42Z87@68525|delta/epsilon subdivisions,2WTYM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1012965_1	572477.Alvin_2087	7.02e-62	202.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1WVUW@135613|Chromatiales	135613|Chromatiales	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_311219_1	1121921.KB898707_gene1208	1.08e-17	84.7	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,2PN1W@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	speA	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008792,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0034641,GO:0042401,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_3590,iE2348C_1286.E2348C_3191,iEC55989_1330.EC55989_3231,iECABU_c1320.ECABU_c32250,iECED1_1282.ECED1_3401,iECIAI1_1343.ECIAI1_3071,iECIAI39_1322.ECIAI39_3358,iECO103_1326.ECO103_3518,iECO26_1355.ECO26_4037,iECOK1_1307.ECOK1_3327,iECP_1309.ECP_2933,iECS88_1305.ECS88_3221,iECSE_1348.ECSE_3207,iECSF_1327.ECSF_2737,iECSP_1301.ECSP_3909,iECUMN_1333.ECUMN_3290,iECW_1372.ECW_m3198,iECs_1301.ECs3814,iEKO11_1354.EKO11_0788,iEcE24377_1341.EcE24377A_3281,iEcHS_1320.EcHS_A3096,iEcolC_1368.EcolC_0773,iG2583_1286.G2583_3597,iLF82_1304.LF82_2157,iNRG857_1313.NRG857_14440,iPC815.YPO0929,iSBO_1134.SBO_3051,iSDY_1059.SDY_3134,iSSON_1240.SSON_3092,iSbBS512_1146.SbBS512_E3371,iWFL_1372.ECW_m3198,iZ_1308.Z4283	Orn_Arg_deC_N
k59_311219_2	859657.RPSI07_1196	1.56e-91	280.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2VHAX@28216|Betaproteobacteria,1K2GD@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Sulfurtransferase	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_311219_3	686340.Metal_2960	2.86e-07	51.2	COG0625@1|root,COG0625@2|Bacteria,1RDQ5@1224|Proteobacteria,1S883@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Glutathione S-Transferase	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_3,GST_N_3
k59_136321_1	1232683.ADIMK_2758	7.36e-49	169.0	COG2211@1|root,COG2211@2|Bacteria,1QTSE@1224|Proteobacteria,1T1FN@1236|Gammaproteobacteria,464T3@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	COG0477 Permeases of the major facilitator superfamily	ampG	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	Acatn,MFS_1
k59_1846171_1	765910.MARPU_00500	7.78e-71	227.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1WXUS@135613|Chromatiales	135613|Chromatiales	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_1256392_1	663610.JQKO01000009_gene393	9.51e-63	203.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2TS2D@28211|Alphaproteobacteria,3NAWG@45404|Beijerinckiaceae	28211|Alphaproteobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
k59_136325_1	999141.GME_04092	8.14e-38	140.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1XHZZ@135619|Oceanospirillales	135619|Oceanospirillales	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_136325_2	1123257.AUFV01000002_gene2419	4.95e-95	287.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1X3NH@135614|Xanthomonadales	135614|Xanthomonadales	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_429164_1	1078020.KEK_20068	7.43e-51	176.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,233MW@1762|Mycobacteriaceae	201174|Actinobacteria	P	Part of the ABC transporter complex FbpABC involved in Fe(3 ) ions import. Responsible for energy coupling to the transport system	fbpC	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
k59_1368506_1	435908.IDSA_10095	4.25e-125	370.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_263257_1	765911.Thivi_1845	1.52e-49	177.0	COG1239@1|root,COG1240@1|root,COG1239@2|Bacteria,COG1240@2|Bacteria,1MYHV@1224|Proteobacteria,1RS9F@1236|Gammaproteobacteria,1WXBD@135613|Chromatiales	135613|Chromatiales	H	introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX	bchD	-	6.6.1.1	ko:K03404	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	VWA_2
k59_1013557_1	570268.ANBB01000046_gene1329	1.51e-16	78.2	COG0595@1|root,COG0595@2|Bacteria,2GIW7@201174|Actinobacteria,4EFRR@85012|Streptosporangiales	201174|Actinobacteria	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
k59_1013557_2	944560.HMPREF9058_2694	2.3e-126	369.0	COG0329@1|root,COG0329@2|Bacteria,2GJ34@201174|Actinobacteria,4D4I9@85005|Actinomycetales	201174|Actinobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_1131519_1	1552758.NC00_11170	4.89e-37	137.0	COG3677@1|root,COG3677@2|Bacteria,1NUTK@1224|Proteobacteria,1S11R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_487957_1	1045855.DSC_09670	4.27e-87	271.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,1RN8U@1236|Gammaproteobacteria,1X3DC@135614|Xanthomonadales	135614|Xanthomonadales	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumB	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
k59_378597_1	1211115.ALIQ01000170_gene4043	1.37e-66	220.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,2TRMQ@28211|Alphaproteobacteria,3NAAB@45404|Beijerinckiaceae	28211|Alphaproteobacteria	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
k59_1193104_1	1049564.TevJSym_av00030	3.91e-42	144.0	COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,1S20Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	dihydroneopterin triphosphate	nudB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008828,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017144,GO:0018130,GO:0019177,GO:0019438,GO:0019752,GO:0034641,GO:0042364,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0046872,GO:0047429,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.6.1.67	ko:K08310	ko00790,map00790	M00126	R04638	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iSFV_1184.SFV_1867,iSF_1195.SF1875,iSFxv_1172.SFxv_2099,iS_1188.S1941,iY75_1357.Y75_RS09795,iYL1228.KPN_02379	NUDIX
k59_1193104_2	1121445.ATUZ01000014_gene1588	5.72e-11	62.8	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria,2M7Y4@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_1778984_1	857571.EA1_06093	1.76e-44	149.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,3NK4T@468|Moraxellaceae	1236|Gammaproteobacteria	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	GO:0002790,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0034613,GO:0042886,GO:0043952,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051082,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0072321	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
k59_1778984_2	1049564.TevJSym_at00220	3.55e-19	85.9	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1J4W3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Glycerol-3-phosphate dehydrogenase	gpsA	GO:0003674,GO:0003824,GO:0004367,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006072,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	iJN746.PP_4169,iSFV_1184.SFV_3923	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_1082307_1	1095769.CAHF01000022_gene339	5.26e-11	69.3	COG4966@1|root,COG4966@2|Bacteria,1RC4Q@1224|Proteobacteria,2VS7N@28216|Betaproteobacteria,476YR@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	Type IV Pilus-assembly protein W	pilW	-	-	ko:K02672	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl,PilW
k59_605129_1	876269.ARWA01000001_gene3707	8.61e-103	308.0	COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2TSQ3@28211|Alphaproteobacteria,3NBEV@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
k59_778618_2	935839.JAGJ01000001_gene1221	7.5e-57	179.0	COG1366@1|root,COG1366@2|Bacteria,2IJQC@201174|Actinobacteria,4F4J3@85017|Promicromonosporaceae	201174|Actinobacteria	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS,STAS_2
k59_429175_1	1304865.JAGF01000001_gene949	1.63e-278	785.0	COG1960@1|root,COG1960@2|Bacteria,2GJ4X@201174|Actinobacteria,4F1TV@85016|Cellulomonadaceae	201174|Actinobacteria	I	Acyl-CoA oxidase	acx	-	1.3.3.6	ko:K00232	ko00071,ko00592,ko01040,ko01100,ko01110,ko01212,ko03320,ko04024,ko04146,map00071,map00592,map01040,map01100,map01110,map01212,map03320,map04024,map04146	M00087,M00113	R01175,R01279,R03777,R03857,R03990,R04751,R04754,R07888,R07892,R07896,R07934,R07950	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	ACOX,Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_429175_2	446469.Sked_34880	1.24e-50	169.0	COG1309@1|root,COG1309@2|Bacteria,2GN0W@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1491089_1	2340.JV46_20190	4.81e-109	331.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1J4E5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_778622_1	1150621.SMUL_0550	4.91e-31	117.0	COG2009@1|root,2ZBTX@2|Bacteria,1RB22@1224|Proteobacteria,42NAY@68525|delta/epsilon subdivisions,2YMAV@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	fumarate reductase	frdC	-	-	ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_136358_1	1123073.KB899242_gene939	1.52e-49	165.0	COG1462@1|root,COG1462@2|Bacteria,1Q8KJ@1224|Proteobacteria,1RU2Q@1236|Gammaproteobacteria,1X6HV@135614|Xanthomonadales	135614|Xanthomonadales	M	Peptidoglycan-synthase activator LpoB	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
k59_1318069_1	1168065.DOK_18855	1.08e-25	107.0	COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,1RQWI@1236|Gammaproteobacteria,1J5R8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_1318069_2	1304883.KI912532_gene1666	3.23e-10	59.3	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2VJPI@28216|Betaproteobacteria,2KUCS@206389|Rhodocyclales	206389|Rhodocyclales	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_906894_2	1121405.dsmv_2796	1.01e-31	118.0	COG1309@1|root,COG1309@2|Bacteria,1R7QV@1224|Proteobacteria,43AFI@68525|delta/epsilon subdivisions,2WINE@28221|Deltaproteobacteria,2MJ31@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1663042_2	595460.RRSWK_01775	8.68e-37	134.0	COG1052@1|root,COG1052@2|Bacteria,2IWTC@203682|Planctomycetes	203682|Planctomycetes	CH	PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_1256444_1	927677.ALVU02000006_gene420	3.08e-113	338.0	COG5433@1|root,COG5433@2|Bacteria,1G2IT@1117|Cyanobacteria	1117|Cyanobacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_378621_1	1227457.C451_03584	9.36e-65	215.0	COG3436@1|root,arCOG04792@2157|Archaea,2XTVF@28890|Euryarchaeota,23U2Z@183963|Halobacteria	183963|Halobacteria	L	COG3436 Transposase and inactivated derivatives	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,SlyX,zf-IS66
k59_664614_1	67356.KL575627_gene3502	0.000254	48.5	COG0739@1|root,COG0739@2|Bacteria,2GNPA@201174|Actinobacteria	201174|Actinobacteria	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I36,Peptidase_M23
k59_906897_1	644107.SL1157_A0191	3.74e-171	492.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1N3PN@1224|Proteobacteria,2U2TJ@28211|Alphaproteobacteria,4NBKA@97050|Ruegeria	28211|Alphaproteobacteria	C	Cytochrome D1 heme domain	nirS	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_906897_2	1123355.JHYO01000029_gene3738	0.000354	43.1	COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,2TURW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c-type protein	-	-	-	ko:K02569	-	-	-	-	ko00000	-	-	-	Cytochrom_NNT
k59_263308_1	1218075.BAYA01000001_gene2	8.02e-30	115.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2VJ2N@28216|Betaproteobacteria,1K319@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Polyhydroxyalkanoate synthesis repressor PhaR	phaR	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
k59_1846244_1	1123065.ATWL01000007_gene3286	1.99e-29	120.0	COG0515@1|root,COG0515@2|Bacteria,2GIW5@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_85056_1	1125863.JAFN01000001_gene2316	1.34e-92	282.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42NH6@68525|delta/epsilon subdivisions,2WJCV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	dapL	GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_906909_1	1121405.dsmv_0272	1.18e-44	160.0	COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,43BJ5@68525|delta/epsilon subdivisions,2X713@28221|Deltaproteobacteria,2MJER@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01990,ko:K13926	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3,ABC_tran
k59_906909_2	1121405.dsmv_0271	2.52e-62	200.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,42NC1@68525|delta/epsilon subdivisions,2WMKG@28221|Deltaproteobacteria,2MPK8@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1544434_1	396588.Tgr7_1477	3.77e-23	102.0	COG0845@1|root,COG0845@2|Bacteria,1PDUT@1224|Proteobacteria,1RQKD@1236|Gammaproteobacteria,1WX86@135613|Chromatiales	135613|Chromatiales	M	HlyD family secretion protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3,OEP
k59_778642_1	1480694.DC28_08930	1.2e-48	167.0	COG1475@1|root,COG1475@2|Bacteria,2J5S6@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_1491120_1	1429851.X548_05525	6.29e-24	103.0	COG0845@1|root,COG0845@2|Bacteria,1R3U4@1224|Proteobacteria,1T2P1@1236|Gammaproteobacteria,1XCVY@135614|Xanthomonadales	135614|Xanthomonadales	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_378646_1	1173020.Cha6605_1901	2.28e-19	89.4	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_1602648_1	568703.LGG_01378	2.74e-17	84.7	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli,3F3V9@33958|Lactobacillaceae	91061|Bacilli	D	recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_311993_1	1049564.TevJSym_bk00260	9.59e-68	225.0	COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1QVHU@1224|Proteobacteria,1T5JJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Sucrose-6F-phosphate phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	S6PP
k59_311993_2	768671.ThimaDRAFT_2891	5.4e-50	168.0	COG0561@1|root,COG0561@2|Bacteria,1QDJR@1224|Proteobacteria,1RSEI@1236|Gammaproteobacteria,1WX4S@135613|Chromatiales	135613|Chromatiales	S	HAD-superfamily hydrolase, subfamily IIB	-	-	-	-	-	-	-	-	-	-	-	-	S6PP,YcgL
k59_263337_1	926550.CLDAP_02220	3.54e-28	119.0	COG2335@1|root,COG2335@2|Bacteria	2|Bacteria	M	COG2335, Secreted and surface protein containing fasciclin-like repeats	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
k59_311995_1	1054213.HMPREF9946_02737	7.48e-46	157.0	COG1407@1|root,COG1407@2|Bacteria,1RC5G@1224|Proteobacteria,2TU2T@28211|Alphaproteobacteria,2JS1N@204441|Rhodospirillales	204441|Rhodospirillales	S	Calcineurin-like phosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
k59_723058_1	472759.Nhal_1615	4.3e-25	104.0	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,1RP1B@1236|Gammaproteobacteria,1WZVK@135613|Chromatiales	135613|Chromatiales	C	Prokaryotic cytochrome b561	-	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
k59_1779036_1	1238186.AOCN01000016_gene236	7.77e-93	276.0	COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria,4FM54@85023|Microbacteriaceae	201174|Actinobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
k59_546576_2	580332.Slit_1144	8.67e-73	227.0	COG0500@1|root,COG0500@2|Bacteria,1RAE4@1224|Proteobacteria,2W039@28216|Betaproteobacteria,44WCJ@713636|Nitrosomonadales	28216|Betaproteobacteria	Q	Thiopurine S-methyltransferase (TPMT)	-	-	2.1.1.67	ko:K00569	ko00983,map00983	-	R08236,R08239,R08246	RC00003,RC00980,RC02277	ko00000,ko00001,ko01000	-	-	-	TPMT
k59_1131579_1	251229.Chro_0250	3.44e-26	113.0	COG1352@1|root,COG1352@2|Bacteria,1G210@1117|Cyanobacteria,3VNG0@52604|Pleurocapsales	1117|Cyanobacteria	NT	COGs COG1352 Methylase of chemotaxis methyl-accepting protein	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheR,CheR_N
k59_605187_1	867903.ThesuDRAFT_01803	2.38e-24	110.0	COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,1UIY4@1239|Firmicutes,25EZX@186801|Clostridia	186801|Clostridia	T	TIGRFAM diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
k59_1193168_1	1304865.JAGF01000001_gene687	1.31e-90	289.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria,4F0E3@85016|Cellulomonadaceae	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_664660_1	1121396.KB893111_gene1926	4.76e-29	112.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,42NFH@68525|delta/epsilon subdivisions,2WITT@28221|Deltaproteobacteria,2MHQE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_1544459_1	40571.JOEA01000001_gene5303	1.38e-57	201.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4E13K@85010|Pseudonocardiales	201174|Actinobacteria	L	DEAD DEAH box helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
k59_546591_1	1173020.Cha6605_5356	2.62e-124	373.0	COG3666@1|root,COG3666@2|Bacteria,1GEUC@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1491165_1	323261.Noc_1458	1.89e-77	243.0	COG0823@1|root,COG0823@2|Bacteria,1QW3I@1224|Proteobacteria,1SYTE@1236|Gammaproteobacteria,1X0JZ@135613|Chromatiales	135613|Chromatiales	U	beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40
k59_664673_1	95619.PM1_0216590	4.36e-51	179.0	COG0025@1|root,COG1226@1|root,COG0025@2|Bacteria,COG1226@2|Bacteria,1QTUE@1224|Proteobacteria,1T1HJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	nhaP	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger,TrkA_N
k59_1544471_1	1515746.HR45_11560	1.14e-74	242.0	COG4805@1|root,COG4805@2|Bacteria,1PIM6@1224|Proteobacteria,1RRW7@1236|Gammaproteobacteria,2QDQS@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_1720505_1	469371.Tbis_1403	3.2e-42	155.0	COG0770@1|root,COG0770@2|Bacteria,2GK0Y@201174|Actinobacteria,4DZ1W@85010|Pseudonocardiales	201174|Actinobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	GO:0008150,GO:0040007	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_965901_1	765912.Thimo_2222	3.7e-55	176.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,1RPW7@1236|Gammaproteobacteria,1WX8C@135613|Chromatiales	135613|Chromatiales	J	Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
k59_965901_2	765913.ThidrDRAFT_0418	1.18e-46	160.0	COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,1WW5X@135613|Chromatiales	135613|Chromatiales	J	Elongation factor P--(R)-beta-lysine ligase	-	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
k59_1368612_1	1121033.AUCF01000004_gene4827	3.73e-96	287.0	COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,2TRRJ@28211|Alphaproteobacteria,2JQ7X@204441|Rhodospirillales	204441|Rhodospirillales	E	COG1177 ABC-type spermidine putrescine transport system, permease component II	potI	-	-	ko:K11074	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	BPD_transp_1
k59_1434406_1	1043493.BBLU01000012_gene342	2.47e-93	285.0	COG0647@1|root,COG0647@2|Bacteria,2GK7V@201174|Actinobacteria	201174|Actinobacteria	G	hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
k59_1434406_2	1095767.CAHD01000216_gene2695	2.23e-56	187.0	COG0457@1|root,COG0457@2|Bacteria,2GKX5@201174|Actinobacteria,4F19B@85016|Cellulomonadaceae	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
k59_272611_1	981369.JQMJ01000003_gene7894	9.19e-78	235.0	COG0634@1|root,COG0634@2|Bacteria,2GMDZ@201174|Actinobacteria,2NEBJ@228398|Streptacidiphilus	201174|Actinobacteria	F	Phosphoribosyl transferase domain	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_976182_1	1032480.MLP_47700	2.09e-102	318.0	COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria,4DNIH@85009|Propionibacteriales	201174|Actinobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_1856678_1	1410616.JHXE01000017_gene1664	1.09e-25	108.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,3NGRH@46205|Pseudobutyrivibrio	186801|Clostridia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_976185_1	446466.Cfla_1660	1.92e-53	180.0	COG4825@1|root,COG4825@2|Bacteria,2GPAA@201174|Actinobacteria,4F0E1@85016|Cellulomonadaceae	201174|Actinobacteria	S	Thiamine pyrophosphokinase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TPPK_C
k59_976185_2	1095767.CAHD01000216_gene2690	2.95e-74	241.0	COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria,4F13H@85016|Cellulomonadaceae	201174|Actinobacteria	L	May be involved in recombinational repair of damaged DNA	recN	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
k59_1608333_1	1713.JOFV01000005_gene2128	5.47e-63	203.0	COG0600@1|root,COG0600@2|Bacteria,2GIWG@201174|Actinobacteria,4F27F@85016|Cellulomonadaceae	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	ssuC3	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_1608333_2	1304865.JAGF01000001_gene2025	1.41e-110	334.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,2GK3B@201174|Actinobacteria,4F0HX@85016|Cellulomonadaceae	201174|Actinobacteria	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	cobA	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,TP_methylase
k59_1856687_1	1232437.KL662047_gene5200	9e-51	181.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,2MIPG@213118|Desulfobacterales	28221|Deltaproteobacteria	G	phosphorylase	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_1199354_1	395493.BegalDRAFT_0847	8.63e-46	157.0	COG1999@1|root,COG1999@2|Bacteria,1RHSV@1224|Proteobacteria,1S6HW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
k59_1199354_2	472759.Nhal_0269	4e-75	234.0	COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,1WWX2@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue	prmB	-	2.1.1.298	ko:K07320	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03009	-	-	-	MTS
k59_1434417_1	1121385.AQXW01000004_gene2408	6.47e-145	421.0	COG2801@1|root,COG3415@1|root,COG2801@2|Bacteria,COG3415@2|Bacteria,2GJ3V@201174|Actinobacteria,1ZWA9@145357|Dermacoccaceae	201174|Actinobacteria	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_29,HTH_32,rve
k59_1856708_1	1234364.AMSF01000001_gene2377	2.01e-68	223.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1X3C1@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1856708_2	1049564.TevJSym_aj00280	6.8e-50	167.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1J4D5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Cell wall formation	murB	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
k59_1263843_1	471853.Bcav_2550	4e-145	447.0	COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria	201174|Actinobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_95340_1	136993.KB900626_gene2482	4.52e-06	54.3	COG0845@1|root,COG0845@2|Bacteria,1MX8W@1224|Proteobacteria,2TRPM@28211|Alphaproteobacteria,36YWH@31993|Methylocystaceae	28211|Alphaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
k59_1018836_1	1193181.BN10_1080003	6.95e-70	211.0	2CNY9@1|root,31GEE@2|Bacteria,2IKKZ@201174|Actinobacteria,4FH2D@85021|Intrasporangiaceae	201174|Actinobacteria	K	Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters	rbpA	-	-	-	-	-	-	-	-	-	-	-	RbpA
k59_1018836_2	561175.KB894096_gene861	1.64e-23	90.9	COG1314@1|root,COG1314@2|Bacteria,2GR31@201174|Actinobacteria,4EKQ0@85012|Streptosporangiales	201174|Actinobacteria	U	Preprotein translocase SecG subunit	secG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
k59_1856711_1	631362.Thi970DRAFT_04788	7.73e-25	108.0	COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,1RQFF@1236|Gammaproteobacteria,1WWF3@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
k59_1263844_1	1249627.D779_3943	3.12e-88	274.0	COG3316@1|root,COG3316@2|Bacteria,1QE29@1224|Proteobacteria,1T5ZZ@1236|Gammaproteobacteria,1X2WN@135613|Chromatiales	135613|Chromatiales	L	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
k59_670557_1	713586.KB900536_gene1847	2.48e-17	86.3	COG3303@1|root,COG3303@2|Bacteria,1QXF8@1224|Proteobacteria,1T3AB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII
k59_1374316_1	1173028.ANKO01000099_gene1534	2.56e-10	68.2	COG2202@1|root,COG4251@1|root,COG5278@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,COG5278@2|Bacteria,1G0A1@1117|Cyanobacteria,1H7JR@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
k59_976222_2	1454004.AW11_03212	5.34e-84	264.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2VIFW@28216|Betaproteobacteria,1KR2K@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	P	C-terminal region of aryl-sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,Sulfatase_C
k59_39306_1	880072.Desac_2136	3.15e-22	92.8	COG1576@1|root,COG1576@2|Bacteria,1N7WB@1224|Proteobacteria,42V41@68525|delta/epsilon subdivisions,2X6IT@28221|Deltaproteobacteria,2MSH7@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
k59_39306_2	909663.KI867150_gene1035	8.14e-29	104.0	COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,42V85@68525|delta/epsilon subdivisions,2WR93@28221|Deltaproteobacteria,2MS8K@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	NifU-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Nfu_N,NifU
k59_1856727_1	234267.Acid_2016	7.22e-104	316.0	COG3344@1|root,COG3344@2|Bacteria,3Y46K@57723|Acidobacteria	57723|Acidobacteria	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1,RVT_N
k59_1726794_1	1123393.KB891316_gene1080	1.57e-13	70.1	COG1018@1|root,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,2VPWB@28216|Betaproteobacteria,1KSZT@119069|Hydrogenophilales	119069|Hydrogenophilales	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2
k59_1726794_2	580332.Slit_1495	1.01e-23	95.5	COG2920@1|root,COG2920@2|Bacteria,1NAQC@1224|Proteobacteria,2VWA3@28216|Betaproteobacteria	28216|Betaproteobacteria	P	DsrC like protein	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_976241_2	1385515.N791_04760	4.22e-38	142.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1X34U@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_494131_1	1288826.MSNKSG1_04721	2.74e-17	82.4	COG1105@1|root,COG1105@2|Bacteria,1MVNW@1224|Proteobacteria,1RP6K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	belongs to the carbohydrate kinase PfkB family	fruK	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0008662,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019318,GO:0019320,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575	2.7.1.11,2.7.1.56	ko:K00882,ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R02071,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2168,iAPECO1_1312.APECO1_4386,iB21_1397.B21_02056,iEC042_1314.EC042_2401,iEC55989_1330.EC55989_2421,iECABU_c1320.ECABU_c24990,iECBD_1354.ECBD_1490,iECB_1328.ECB_02097,iECDH10B_1368.ECDH10B_2325,iECDH1ME8569_1439.ECDH1ME8569_2104,iECD_1391.ECD_02097,iECED1_1282.ECED1_2616,iECH74115_1262.ECH74115_3304,iECIAI1_1343.ECIAI1_2248,iECIAI39_1322.ECIAI39_2308,iECNA114_1301.ECNA114_2259,iECO103_1326.ECO103_2643,iECO111_1330.ECO111_2886,iECO26_1355.ECO26_3080,iECOK1_1307.ECOK1_2400,iECP_1309.ECP_2208,iECS88_1305.ECS88_2316,iECSE_1348.ECSE_2436,iECSF_1327.ECSF_2049,iECSP_1301.ECSP_3046,iECUMN_1333.ECUMN_2504,iECW_1372.ECW_m2369,iECs_1301.ECs3060,iEKO11_1354.EKO11_1586,iETEC_1333.ETEC_2303,iEcDH1_1363.EcDH1_1490,iEcHS_1320.EcHS_A2305,iEcSMS35_1347.EcSMS35_2315,iEcolC_1368.EcolC_1480,iG2583_1286.G2583_2711,iJO1366.b2168,iJR904.b2168,iLF82_1304.LF82_0744,iNRG857_1313.NRG857_11005,iPC815.YPO1299,iSBO_1134.SBO_2156,iSDY_1059.SDY_2316,iSFV_1184.SFV_2243,iSF_1195.SF2253,iSFxv_1172.SFxv_2486,iS_1188.S2382,iUMN146_1321.UM146_05955,iUMNK88_1353.UMNK88_2713,iUTI89_1310.UTI89_C2443,iWFL_1372.ECW_m2369,iY75_1357.Y75_RS11345,iZ_1308.Z3426,ic_1306.c2703	PfkB
k59_435348_1	395965.Msil_2986	1.26e-98	303.0	COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria,3NC7S@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_9,Pyr_redox_2,Pyr_redox_3
k59_39322_1	765913.ThidrDRAFT_2658	3.22e-56	187.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,1WXK9@135613|Chromatiales	135613|Chromatiales	C	Belongs to the heme-copper respiratory oxidase family	-	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_39322_2	765910.MARPU_02785	3.71e-42	147.0	COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,1WVWC@135613|Chromatiales	135613|Chromatiales	K	TIGRFAM RNA polymerase sigma factor RpoS	rpoS	-	-	ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1089817_1	1255043.TVNIR_3845	6.62e-27	109.0	COG3031@1|root,COG3031@2|Bacteria,1RD3I@1224|Proteobacteria,1RQKA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	General secretion pathway protein C	gspC	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K02452	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	PDZ_2,T2SSC
k59_552773_1	1100720.ALKN01000035_gene995	1.21e-91	286.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2VIY8@28216|Betaproteobacteria,4AHFM@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_95401_1	1122604.JONR01000011_gene3684	6.25e-107	323.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RQE4@1236|Gammaproteobacteria,1X59Z@135614|Xanthomonadales	135614|Xanthomonadales	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_95401_2	404589.Anae109_0596	8.38e-21	89.7	COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,42MJI@68525|delta/epsilon subdivisions,2WJQP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	6-phosphogluconate dehydrogenase (decarboxylating)	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2620	6PGD,NAD_binding_2
k59_318402_1	765911.Thivi_3155	6.84e-69	227.0	COG1165@1|root,COG1165@2|Bacteria,1MVMZ@1224|Proteobacteria,1RNRS@1236|Gammaproteobacteria,1WW3X@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	-	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N
k59_388905_1	1163409.UUA_17350	5.52e-59	196.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1X3A8@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	atoB	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1608385_2	590998.Celf_2052	2.19e-07	51.6	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria	201174|Actinobacteria	P	Heavy metal translocating P-type atpase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_318411_1	269799.Gmet_3333	3.49e-20	91.3	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,42SV9@68525|delta/epsilon subdivisions,2WPXX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Phosphoribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
k59_917221_1	28444.JODQ01000002_gene4082	2.94e-63	212.0	COG0747@1|root,COG0747@2|Bacteria,2GNKN@201174|Actinobacteria,4EGG4@85012|Streptosporangiales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_95426_1	252305.OB2597_06110	4.81e-35	130.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,2TST5@28211|Alphaproteobacteria,2PDJ8@252301|Oceanicola	28211|Alphaproteobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_95426_2	1147.D082_16760	1.86e-07	55.1	COG3556@1|root,COG3556@2|Bacteria,1G6VI@1117|Cyanobacteria,1H62G@1142|Synechocystis	1117|Cyanobacteria	S	Predicted membrane protein (DUF2214)	-	-	-	ko:K08983	-	-	-	-	ko00000	-	-	-	DUF2214
k59_95426_3	1230343.CANP01000015_gene1281	7.88e-11	62.4	COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,1RMKJ@1236|Gammaproteobacteria,1JCNC@118969|Legionellales	118969|Legionellales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1498346_1	4577.GRMZM2G088847_P02	4.93e-16	75.5	KOG1759@1|root,KOG1759@2759|Eukaryota,37UTD@33090|Viridiplantae,3GIJ1@35493|Streptophyta,3M05M@4447|Liliopsida,3II2C@38820|Poales	35493|Streptophyta	V	Macrophage migration inhibitory factor (MIF)	-	-	5.3.2.1	ko:K07253	ko00350,ko00360,map00350,map00360	-	R01378,R03342	RC00507	ko00000,ko00001,ko01000,ko04147	-	-	-	MIF
k59_1498346_2	1249627.D779_0385	4.18e-171	493.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1WXRW@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_1199416_1	305700.B447_20091	4.49e-06	48.5	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	DUF3318,Peptidase_M48
k59_1199416_2	1211112.ALJC01000107_gene2781	2.29e-105	317.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_435379_1	713586.KB900536_gene657	2.03e-23	99.8	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1WWT9@135613|Chromatiales	135613|Chromatiales	O	Belongs to the ClpA ClpB family	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_95432_1	933262.AXAM01000015_gene116	2.88e-25	107.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2WJPF@28221|Deltaproteobacteria,2MIBD@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_95432_2	644282.Deba_1415	6.89e-14	67.8	COG0268@1|root,COG0268@2|Bacteria,1NITA@1224|Proteobacteria,42V4U@68525|delta/epsilon subdivisions,2WR9I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
k59_976307_1	1184267.A11Q_1762	7.03e-43	160.0	COG4913@1|root,COG4913@2|Bacteria,1N16Z@1224|Proteobacteria,42MTB@68525|delta/epsilon subdivisions,2WKZ0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SbcCD_C
k59_494148_2	1089550.ATTH01000001_gene802	9.96e-39	147.0	COG4974@1|root,COG4974@2|Bacteria,4PJBF@976|Bacteroidetes,1FKA1@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
k59_918684_2	592010.GCWU000182_000703	4.94e-08	58.5	COG0110@1|root,COG0110@2|Bacteria,1TQEX@1239|Firmicutes,4HGH2@91061|Bacilli,27E2Q@186827|Aerococcaceae	91061|Bacilli	S	Bacterial transferase hexapeptide repeat protein	thgA3	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2,Mac
k59_1435295_1	1510531.JQJJ01000008_gene3920	2.83e-113	342.0	COG2943@1|root,COG2943@2|Bacteria,1MVXZ@1224|Proteobacteria,2TQU8@28211|Alphaproteobacteria,3K2N6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase family group 2	-	-	-	ko:K03669	-	-	-	-	ko00000,ko01000,ko01003,ko02000	4.D.3.1.1	GT2	-	Glyco_trans_2_3,Glycos_transf_2
k59_1551084_1	1120956.JHZK01000001_gene3371	1.77e-136	395.0	COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2TQVW@28211|Alphaproteobacteria,1JPPC@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP,TAT_signal
k59_1858274_1	1121405.dsmv_0128	5.62e-12	74.7	COG2982@1|root,COG2982@2|Bacteria,1MUAN@1224|Proteobacteria,42P9Q@68525|delta/epsilon subdivisions,2WKH7@28221|Deltaproteobacteria,2MPSZ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM AsmA family protein	-	-	-	ko:K07290	-	-	-	-	ko00000	9.B.121	-	-	AsmA
k59_1375158_1	697282.Mettu_3861	6.81e-161	464.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1XEMS@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_390380_1	1713.JOFV01000010_gene1177	8.45e-32	127.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2GJHB@201174|Actinobacteria,4F1V9@85016|Cellulomonadaceae	201174|Actinobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
k59_40288_1	1265505.ATUG01000002_gene2708	1.99e-85	259.0	COG0407@1|root,COG0407@2|Bacteria,1Q2RU@1224|Proteobacteria,42Q1G@68525|delta/epsilon subdivisions,2WJQU@28221|Deltaproteobacteria,2MIA3@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_729962_1	1304865.JAGF01000001_gene2691	1.18e-194	555.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4F0VR@85016|Cellulomonadaceae	201174|Actinobacteria	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1727667_1	160492.XF_0603	3.57e-11	65.5	COG0031@1|root,COG0517@1|root,COG0031@2|Bacteria,COG0517@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1X4GC@135614|Xanthomonadales	135614|Xanthomonadales	E	Cystathionine beta-synthase	cysB	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
k59_1727667_2	666685.R2APBS1_0575	3.15e-181	514.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1X4AH@135614|Xanthomonadales	135614|Xanthomonadales	E	cystathionine	-	-	4.4.1.1	ko:K01758	ko00260,ko00270,ko00450,ko01100,ko01130,ko01230,map00260,map00270,map00450,map01100,map01130,map01230	M00338	R00782,R01001,R02408,R04770,R04930,R09366	RC00056,RC00069,RC00348,RC00382,RC00710,RC01209,RC01210,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
k59_977839_1	935845.JADQ01000013_gene3358	9.84e-58	187.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,26Q92@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_1551102_1	1120949.KB903303_gene6796	2.07e-17	87.4	COG0656@1|root,COG0656@2|Bacteria	2|Bacteria	S	aldo-keto reductase (NADP) activity	ytbE	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,DUF4157
k59_1019570_1	743718.Isova_0073	6.44e-48	177.0	COG1403@1|root,COG1403@2|Bacteria,2HAHI@201174|Actinobacteria,4F3G4@85017|Promicromonosporaceae	201174|Actinobacteria	V	Domain of unknown function (DUF222)	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_729973_1	765910.MARPU_08135	3.94e-08	56.2	COG1357@1|root,COG1357@2|Bacteria,1N7U9@1224|Proteobacteria,1RYAA@1236|Gammaproteobacteria,1WXSC@135613|Chromatiales	135613|Chromatiales	S	PFAM Pentapeptide	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
k59_612310_1	1121004.ATVC01000003_gene445	2.04e-29	116.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2VICZ@28216|Betaproteobacteria,2KQ5P@206351|Neisseriales	206351|Neisseriales	M	Lipid A biosynthesis (KDO)2-(Lauroyl)-lipid IVA acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_1785335_1	1394178.AWOO02000093_gene8064	1.71e-12	73.6	COG1404@1|root,COG1404@2|Bacteria,2GNIX@201174|Actinobacteria,4EIJI@85012|Streptosporangiales	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_273548_1	583355.Caka_2711	2.35e-90	296.0	COG0086@1|root,COG0086@2|Bacteria,46S79@74201|Verrucomicrobia,3K7EI@414999|Opitutae	414999|Opitutae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1330072_1	261292.Nit79A3_0624	2.85e-77	244.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2W99D@28216|Betaproteobacteria,3745M@32003|Nitrosomonadales	28216|Betaproteobacteria	C	TIGRFAM Acetyl-CoA carboxylase, biotin carboxylase	-	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_1551111_1	1117647.M5M_02520	2.93e-15	77.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1J4I4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	chorismate mutase	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
k59_1551111_2	1415780.JPOG01000001_gene1175	2.43e-18	84.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,1X4WZ@135614|Xanthomonadales	135614|Xanthomonadales	EH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_1019575_1	196367.JNFG01000009_gene6338	3.36e-22	100.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VNNI@28216|Betaproteobacteria,1K3QF@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_96989_1	1123401.JHYQ01000007_gene542	1.11e-175	516.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,461JN@72273|Thiotrichales	72273|Thiotrichales	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1785345_1	1123368.AUIS01000008_gene2228	4.35e-84	263.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,2NCCU@225057|Acidithiobacillales	225057|Acidithiobacillales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_1019579_2	314345.SPV1_13177	3.6e-42	149.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria	1224|Proteobacteria	M	mechanosensitive ion channel	ynaI	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
k59_1733836_1	187272.Mlg_0280	9.08e-36	139.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1WWY6@135613|Chromatiales	135613|Chromatiales	U	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
k59_1733836_2	1042876.PPS_0775	2.13e-32	121.0	COG3017@1|root,COG3017@2|Bacteria,1N02T@1224|Proteobacteria,1S91E@1236|Gammaproteobacteria,1YV5A@136845|Pseudomonas putida group	1236|Gammaproteobacteria	M	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein	lolB	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0010876,GO:0016020,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0034613,GO:0042157,GO:0042277,GO:0043170,GO:0044238,GO:0044462,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0051668,GO:0070727,GO:0071704,GO:0071723,GO:0071944,GO:0072657,GO:1901564	-	ko:K02494	-	-	-	-	ko00000	-	-	-	LolB
k59_1143418_1	768066.HELO_3903	8.58e-39	146.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1XH3Z@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
k59_1506471_1	1108045.GORHZ_025_00400	1.45e-31	122.0	arCOG10607@1|root,30Y0T@2|Bacteria,2I8NG@201174|Actinobacteria,4GH3Z@85026|Gordoniaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1506471_2	590998.Celf_0637	1.91e-30	116.0	2CA7I@1|root,30E5G@2|Bacteria,2IJ78@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_107498_1	471853.Bcav_1901	5.68e-116	353.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria	201174|Actinobacteria	I	AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_618473_1	1038866.KB902773_gene863	4.53e-40	151.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_1558181_1	575540.Isop_1966	3.41e-12	68.6	COG0561@1|root,COG0561@2|Bacteria,2J0VT@203682|Planctomycetes	203682|Planctomycetes	S	TIGRFAM Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
k59_1558181_2	281090.Lxx18550	9.15e-73	231.0	COG1349@1|root,COG1349@2|Bacteria,2H5X4@201174|Actinobacteria,4FMRK@85023|Microbacteriaceae	201174|Actinobacteria	K	DeoR C terminal sensor domain	-	-	-	ko:K02081,ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
k59_1677363_1	1268622.AVS7_01344	6.96e-27	112.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2VMP7@28216|Betaproteobacteria	28216|Betaproteobacteria	E	amino acid	steT	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_1272990_1	870187.Thini_1261	2.3e-66	223.0	2DBRU@1|root,2ZANA@2|Bacteria,1NIAW@1224|Proteobacteria,1SGWV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_402218_1	1123274.KB899414_gene3605	8.02e-41	146.0	COG2199@1|root,COG4251@1|root,COG3706@2|Bacteria,COG4251@2|Bacteria,2JAW9@203691|Spirochaetes	203691|Spirochaetes	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_50851_1	396588.Tgr7_2713	2.36e-92	283.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1WX43@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
k59_50851_2	105559.Nwat_0242	2.59e-208	587.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,1WWG7@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_50851_3	1121288.AULL01000013_gene1558	6.88e-13	67.8	COG2885@1|root,COG3808@1|root,COG2885@2|Bacteria,COG3808@2|Bacteria,4NF2I@976|Bacteroidetes,1HWN8@117743|Flavobacteriia,3ZPSD@59732|Chryseobacterium	976|Bacteroidetes	CM	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase,OmpA
k59_402221_1	1121904.ARBP01000009_gene4312	1.37e-80	260.0	COG0243@1|root,COG0243@2|Bacteria,4PIKB@976|Bacteroidetes,47NQZ@768503|Cytophagia	976|Bacteroidetes	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_50853_1	525903.Taci_1750	2.65e-80	254.0	COG0369@1|root,COG1151@2|Bacteria,3TA79@508458|Synergistetes	508458|Synergistetes	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
k59_930586_1	999611.KI421504_gene2999	3.53e-49	171.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TR32@28211|Alphaproteobacteria,280C8@191028|Leisingera	28211|Alphaproteobacteria	IQ	Beta-ketoacyl synthase, C-terminal domain	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1870239_1	1469245.JFBG01000027_gene1498	0.000747	40.8	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1S8RQ@1236|Gammaproteobacteria,1WZ4Z@135613|Chromatiales	135613|Chromatiales	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
k59_1442415_1	1307761.L21SP2_0297	8.16e-15	69.7	COG0824@1|root,COG0824@2|Bacteria	2|Bacteria	IQ	Thioesterase	ysmA	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
k59_150588_1	688245.CtCNB1_2357	5.03e-47	171.0	COG2199@1|root,COG2200@1|root,COG5002@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WHDZ@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_4,PAS_9
k59_1207236_1	365044.Pnap_3840	9.78e-150	429.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2VP9R@28216|Betaproteobacteria,4AI23@80864|Comamonadaceae	28216|Betaproteobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_1273000_2	314278.NB231_01374	1.63e-62	207.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1WWJ8@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_678895_1	765912.Thimo_3397	2.55e-81	256.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1WX8S@135613|Chromatiales	135613|Chromatiales	P	PFAM phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_50860_1	1193181.BN10_820029	4.4e-76	229.0	COG1522@1|root,COG1522@2|Bacteria,2H7NM@201174|Actinobacteria,4FGJD@85021|Intrasporangiaceae	201174|Actinobacteria	K	AsnC family transcriptional regulator	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
k59_50860_2	313589.JNB_06479	1.07e-15	75.9	COG1061@1|root,COG1061@2|Bacteria,2GIU5@201174|Actinobacteria,4FEPT@85021|Intrasporangiaceae	201174|Actinobacteria	L	Type III restriction enzyme, res subunit	sdrA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ResIII
k59_930599_1	269796.Rru_A3237	2.61e-08	58.9	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria,2JQZE@204441|Rhodospirillales	204441|Rhodospirillales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_854452_1	411467.BACCAP_04243	1.05e-17	88.6	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,267YU@186813|unclassified Clostridiales	186801|Clostridia	M	Psort location CytoplasmicMembrane, score	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_50861_1	234621.RER_39540	2.6e-23	102.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4FUCE@85025|Nocardiaceae	201174|Actinobacteria	I	acyl-CoA dehydrogenase	fadE9	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_790479_1	479431.Namu_3507	8.81e-96	284.0	COG1392@1|root,COG1392@2|Bacteria,2IIE4@201174|Actinobacteria	201174|Actinobacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_1734636_2	519989.ECTPHS_01684	4e-111	326.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,1WW0D@135613|Chromatiales	135613|Chromatiales	S	PFAM ABC transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
k59_1207241_1	525368.HMPREF0591_0027	1.03e-81	247.0	COG2267@1|root,COG2267@2|Bacteria,2HP8N@201174|Actinobacteria,235XB@1762|Mycobacteriaceae	2|Bacteria	I	Alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
k59_678899_1	340177.Cag_0861	6.07e-33	130.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1FD6X@1090|Chlorobi	1090|Chlorobi	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_1382441_1	631362.Thi970DRAFT_03037	3.82e-23	102.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1WXQJ@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_1342023_1	1031711.RSPO_c02362	5.24e-63	201.0	COG3676@1|root,COG3676@2|Bacteria,1QTF7@1224|Proteobacteria,2VQDW@28216|Betaproteobacteria	28216|Betaproteobacteria	L	ISXO2-like transposase domain	-	-	-	ko:K07488	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1595
k59_737543_1	234267.Acid_0183	1.08e-73	242.0	COG0243@1|root,COG0243@2|Bacteria,3Y2HB@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_50869_1	1123251.ATWM01000015_gene1423	4.43e-10	63.2	COG1716@1|root,COG1716@2|Bacteria,2GK5I@201174|Actinobacteria,4FG8G@85021|Intrasporangiaceae	201174|Actinobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
k59_50869_2	313589.JNB_12983	3.66e-78	246.0	COG2304@1|root,COG2304@2|Bacteria,2GMWM@201174|Actinobacteria,4FF26@85021|Intrasporangiaceae	201174|Actinobacteria	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2,VWA_3
k59_502035_1	1283300.ATXB01000001_gene760	1.09e-57	182.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,1S4VI@1236|Gammaproteobacteria,1XF76@135618|Methylococcales	135618|Methylococcales	O	PFAM Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_502035_2	686340.Metal_2027	5.43e-14	69.7	COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,1SAHT@1236|Gammaproteobacteria,1XGEW@135618|Methylococcales	135618|Methylococcales	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_737547_1	472759.Nhal_2628	1.6e-22	100.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1WXK8@135613|Chromatiales	135613|Chromatiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1558220_1	367299.JOEE01000004_gene1041	4.72e-123	374.0	COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria,4FFHK@85021|Intrasporangiaceae	201174|Actinobacteria	G	phosphorylase	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_209099_1	582899.Hden_3377	9.08e-85	269.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2UCUD@28211|Alphaproteobacteria,3N7UH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	YkuD
k59_502040_1	666509.RCA23_c13130	5.22e-142	410.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,2TTG7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	InterPro IPR001584 COGs COG2801	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve
k59_1382459_1	314278.NB231_08635	9.79e-116	346.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1WX3A@135613|Chromatiales	135613|Chromatiales	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_502041_1	1265313.HRUBRA_01484	2.82e-26	106.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1J4YI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Predicted permease YjgP/YjgQ family	lptF	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_502041_2	1265313.HRUBRA_01483	1.96e-34	131.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,1J4SM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Permease	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_560650_1	471853.Bcav_0007	8.48e-124	379.0	COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0008094,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034335,GO:0042623,GO:0061505,GO:0140097	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1207265_1	479431.Namu_4487	1.35e-13	76.3	COG3385@1|root,COG5659@1|root,COG3385@2|Bacteria,COG5659@2|Bacteria,2GIU9@201174|Actinobacteria,4ETY1@85013|Frankiales	201174|Actinobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_989846_1	313589.JNB_10674	1.14e-44	157.0	COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,4FF5X@85021|Intrasporangiaceae	201174|Actinobacteria	C	CoA-transferase family III	Amacr	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
k59_402288_1	1123367.C666_07305	3.37e-50	172.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VK9J@28216|Betaproteobacteria,2KUE1@206389|Rhodocyclales	206389|Rhodocyclales	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_1677413_1	105559.Nwat_2229	2.65e-07	51.2	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1RNU8@1236|Gammaproteobacteria,1WX5I@135613|Chromatiales	135613|Chromatiales	J	Belongs to the SUA5 family	-	-	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
k59_1677413_2	105559.Nwat_1995	9.52e-85	256.0	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,1S4N8@1236|Gammaproteobacteria,1WWRR@135613|Chromatiales	135613|Chromatiales	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
k59_108772_1	382464.ABSI01000017_gene68	3.34e-47	179.0	COG1404@1|root,COG3533@1|root,COG3940@1|root,COG4733@1|root,COG1404@2|Bacteria,COG3533@2|Bacteria,COG3940@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.2.1.51,3.2.1.78	ko:K01206,ko:K01218,ko:K09955	ko00051,ko00511,ko02024,map00051,map00511,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000,ko04147	-	GH26,GH29	-	Alginate_lyase,Laminin_G_3,PPC,Peptidase_M8,Peptidase_S8,RicinB_lectin_2,SLH,fn3
k59_502045_1	765912.Thimo_1365	5.35e-266	734.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1WWBG@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_989856_1	1042377.AFPJ01000032_gene2689	1.66e-93	289.0	COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,1RNTZ@1236|Gammaproteobacteria,464CU@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	iECABU_c1320.ECABU_c18930,iECED1_1282.ECED1_1841,ic_1306.c2032	AnmK
k59_930654_1	1197906.CAJQ02000029_gene3943	1.67e-11	65.1	COG1073@1|root,COG1073@2|Bacteria,1MX88@1224|Proteobacteria,2TSRE@28211|Alphaproteobacteria,3JSR8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Serine aminopeptidase, S33	MA20_24420	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,Hydrolase_4
k59_1207275_1	768671.ThimaDRAFT_0249	1.34e-103	310.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,1WWZH@135613|Chromatiales	135613|Chromatiales	EH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_1207275_2	1121939.L861_18145	3.36e-14	71.6	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1XIJ6@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_1442462_1	1163617.SCD_n01153	5.52e-40	144.0	COG2391@1|root,COG2391@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_1734679_1	760117.JN27_18505	1.96e-67	224.0	COG4249@1|root,COG4249@2|Bacteria,1MYPK@1224|Proteobacteria	1224|Proteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
k59_1791480_1	743299.Acife_2361	2.64e-43	152.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,2NE61@225057|Acidithiobacillales	1236|Gammaproteobacteria	L	PFAM Transposase, IS116 IS110 IS902	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1791480_3	93220.LV28_05985	1.02e-32	114.0	COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2VTZ8@28216|Betaproteobacteria,1K8WW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	similarity to SP P24580	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1098602_1	485918.Cpin_0998	3.76e-35	133.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,4NESR@976|Bacteroidetes,1IQI9@117747|Sphingobacteriia	976|Bacteroidetes	L	DNA ligase	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
k59_402303_1	441620.Mpop_3619	4.03e-35	122.0	COG3631@1|root,COG3631@2|Bacteria,1RISB@1224|Proteobacteria,2UAAK@28211|Alphaproteobacteria,1JXU2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
k59_1558257_1	1121406.JAEX01000021_gene1451	5.74e-67	214.0	COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,42MZU@68525|delta/epsilon subdivisions,2WKKU@28221|Deltaproteobacteria,2M7X4@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Nitrate reductase gamma subunit	dsrM	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
k59_1207285_1	765911.Thivi_3466	3.54e-85	266.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1WWMF@135613|Chromatiales	135613|Chromatiales	O	PFAM Magnesium chelatase, ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_502061_1	1279038.KB907352_gene2266	1.55e-41	145.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2TRZZ@28211|Alphaproteobacteria,2JPI2@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
k59_502061_2	1205680.CAKO01000040_gene812	6.34e-06	45.4	COG0762@1|root,COG0762@2|Bacteria,1N73Q@1224|Proteobacteria,2UFZR@28211|Alphaproteobacteria,2JU21@204441|Rhodospirillales	204441|Rhodospirillales	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
k59_1558258_1	1121106.JQKB01000014_gene5655	3.83e-13	68.9	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2TQQ1@28211|Alphaproteobacteria,2JPU0@204441|Rhodospirillales	204441|Rhodospirillales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
k59_1558258_2	1163617.SCD_n02012	2.81e-62	205.0	COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,2VNGV@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1342099_2	1500893.JQNB01000001_gene2206	2.33e-19	88.6	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1X4VI@135614|Xanthomonadales	135614|Xanthomonadales	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_1734695_1	1552123.EP57_05880	1.92e-34	131.0	COG1690@1|root,COG1690@2|Bacteria,1TPJ2@1239|Firmicutes,4HARQ@91061|Bacilli,26K8Y@186820|Listeriaceae	91061|Bacilli	S	tRNA-splicing ligase RtcB	-	-	-	-	-	-	-	-	-	-	-	-	RtcB
k59_1734695_2	525898.Sdel_1765	3.08e-08	53.9	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,42QX8@68525|delta/epsilon subdivisions,2YP1G@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_449396_2	927658.AJUM01000022_gene1067	7.03e-05	44.3	COG2836@1|root,COG2836@2|Bacteria,4NIC3@976|Bacteroidetes,2FZDZ@200643|Bacteroidia,3XK14@558415|Marinilabiliaceae	976|Bacteroidetes	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD_2
k59_1279471_1	1121405.dsmv_3565	2.04e-114	332.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,42M5X@68525|delta/epsilon subdivisions,2WJGN@28221|Deltaproteobacteria,2MIGC@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_291390_1	1117943.SFHH103_03319	2.49e-10	66.6	COG1752@1|root,COG1752@2|Bacteria,1Q810@1224|Proteobacteria,2VE6N@28211|Alphaproteobacteria,4BD9Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_214963_1	670307.HYPDE_35228	6.81e-85	264.0	COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria,3N676@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	response regulator	pleD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,Response_reg
k59_156691_1	911045.PSE_1475	1.15e-58	198.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2TSTH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_1448081_1	1232437.KL662058_gene3954	1.2e-13	77.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WKB1@28221|Deltaproteobacteria,2MIJB@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_625306_1	1121405.dsmv_1728	5.15e-95	285.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,42MAM@68525|delta/epsilon subdivisions,2WK4Y@28221|Deltaproteobacteria,2MJCE@213118|Desulfobacterales	28221|Deltaproteobacteria	D	PFAM ABC transporter	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_1212868_1	1005999.GLGR_3322	6.61e-23	92.8	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,1S40Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length	greB	GO:0006139,GO:0006351,GO:0006352,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010604,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031437,GO:0031439,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903311,GO:1903313,GO:1903506,GO:2000112,GO:2001141	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_1212868_2	313598.MED152_05785	9.43e-27	108.0	COG1960@1|root,COG1960@2|Bacteria,4NEHA@976|Bacteroidetes,1HWV4@117743|Flavobacteriia,3VVGG@52959|Polaribacter	976|Bacteroidetes	C	Acyl-CoA dehydrogenase, C-terminal domain	acdA	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1683082_2	497321.C664_06253	6.59e-79	243.0	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VX1Q@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_291439_1	187272.Mlg_1865	2.78e-107	337.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales	135613|Chromatiales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2
k59_1448090_1	411684.HPDFL43_06560	3.14e-50	162.0	COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,2U9FX@28211|Alphaproteobacteria,43K11@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
k59_1448090_2	1122214.AQWH01000014_gene3667	0.000349	42.7	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2U592@28211|Alphaproteobacteria,2PJKX@255475|Aurantimonadaceae	28211|Alphaproteobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_1279508_2	390989.JOEG01000009_gene988	1.48e-14	72.0	2C4MW@1|root,32RKK@2|Bacteria,2IQ6A@201174|Actinobacteria,4DE2H@85008|Micromonosporales	201174|Actinobacteria	S	Lsr2	lsr2	GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009405,GO:0009605,GO:0009628,GO:0009636,GO:0009889,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010039,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031668,GO:0033554,GO:0034641,GO:0040007,GO:0042221,GO:0042262,GO:0042493,GO:0042542,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051704,GO:0051716,GO:0060255,GO:0065007,GO:0070482,GO:0070887,GO:0071453,GO:0071496,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	Lsr2
k59_1032113_1	37919.EP51_25960	5.46e-07	52.8	COG2207@1|root,COG2207@2|Bacteria,2IBP1@201174|Actinobacteria,4FVP2@85025|Nocardiaceae	201174|Actinobacteria	K	AraC family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding_2,HTH_18
k59_1032113_2	263358.VAB18032_10565	4.04e-09	62.8	COG2355@1|root,COG2355@2|Bacteria,2GN82@201174|Actinobacteria,4DFCE@85008|Micromonosporales	201174|Actinobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_1149524_1	2340.JV46_14270	2.48e-21	92.0	COG1394@1|root,COG1394@2|Bacteria,1RJ1P@1224|Proteobacteria,1S75D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	ATP synthase subunit D	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
k59_1149524_2	2340.JV46_14280	3.08e-107	323.0	COG1156@1|root,COG1156@2|Bacteria,1QUQE@1224|Proteobacteria,1T210@1236|Gammaproteobacteria,1JC0C@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_ab
k59_1388333_2	1449357.JQLK01000001_gene2200	8.02e-98	305.0	COG0281@1|root,COG0281@2|Bacteria,1WIZY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	PFAM Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
k59_566697_1	67267.JNXT01000016_gene3543	9.5e-40	142.0	COG0189@1|root,COG0189@2|Bacteria,2HI2Z@201174|Actinobacteria	201174|Actinobacteria	HJ	ligase activity	dcsG	-	-	-	-	-	-	-	-	-	-	-	-
k59_1105082_1	1026882.MAMP_01308	2.21e-61	201.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,460DV@72273|Thiotrichales	72273|Thiotrichales	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,Response_reg
k59_1740883_1	626887.J057_05251	1.29e-26	110.0	COG4849@1|root,COG4849@2|Bacteria,1N4EJ@1224|Proteobacteria,1S4E0@1236|Gammaproteobacteria,46B55@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
k59_1740883_2	208439.AJAP_33285	1.35e-13	70.9	COG4861@1|root,COG4861@2|Bacteria,2INUD@201174|Actinobacteria	201174|Actinobacteria	S	Transcriptional regulator, AbiEi antitoxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_2
k59_449449_1	335543.Sfum_3195	1.92e-61	207.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42MYN@68525|delta/epsilon subdivisions,2WIND@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_743659_1	517418.Ctha_0919	2.29e-11	64.7	COG0581@1|root,COG0581@2|Bacteria,1FE3G@1090|Chlorobi	1090|Chlorobi	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstA	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_743659_2	517418.Ctha_0918	1.16e-40	142.0	COG0573@1|root,COG0573@2|Bacteria,1FE1M@1090|Chlorobi	1090|Chlorobi	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstC	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_1032138_2	471853.Bcav_3072	2.08e-68	211.0	COG0802@1|root,COG0802@2|Bacteria,2IKV2@201174|Actinobacteria	201174|Actinobacteria	K	ATPase or kinase	tsaE	GO:0008150,GO:0040007	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
k59_1279531_1	439235.Dalk_3802	6.85e-112	329.0	COG0559@1|root,COG0559@2|Bacteria,1N54M@1224|Proteobacteria,42PNV@68525|delta/epsilon subdivisions,2WJVJ@28221|Deltaproteobacteria,2MK8B@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1279531_2	292459.STH704	2.47e-14	73.2	COG1022@1|root,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,25E9H@186801|Clostridia	186801|Clostridia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_684984_1	768671.ThimaDRAFT_3378	9.76e-45	161.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1WVV0@135613|Chromatiales	135613|Chromatiales	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_684984_2	94624.Bpet3266	1.38e-40	142.0	2C852@1|root,32YB2@2|Bacteria,1RH28@1224|Proteobacteria,2VSQ3@28216|Betaproteobacteria,3T6ZC@506|Alcaligenaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
k59_1149541_1	1232410.KI421412_gene116	4.07e-49	167.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,42NZP@68525|delta/epsilon subdivisions,2WKZA@28221|Deltaproteobacteria,43S59@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	6.1.1.17	ko:K01885,ko:K01894	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_216111_1	156889.Mmc1_3011	3.84e-29	117.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria	1224|Proteobacteria	T	COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_216111_2	1191523.MROS_2662	0.000449	41.6	COG0167@1|root,COG0167@2|Bacteria	2|Bacteria	F	dihydroorotate dehydrogenase activity	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_1150617_1	1121022.ABENE_13040	1.34e-53	188.0	COG5659@1|root,COG5659@2|Bacteria,1MWAV@1224|Proteobacteria,2U2Q3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_861367_1	1205753.A989_15492	1.14e-53	185.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1X4IP@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA	rlmD	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_1214175_1	384765.SIAM614_04765	0.000575	48.5	COG0668@1|root,COG0668@2|Bacteria,1MY0I@1224|Proteobacteria,2TSIN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	mechanosensitive ion channel	-	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
k59_293262_1	911239.CF149_18336	8.29e-38	134.0	COG0835@1|root,COG0835@2|Bacteria,1RCIR@1224|Proteobacteria,1S61F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NT	chemotaxis signal transduction protein	pilI	-	-	ko:K02659	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	CheW
k59_509422_1	1267005.KB911255_gene2866	1.31e-136	397.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TT2C@28211|Alphaproteobacteria,3N64E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	FP	Ppx/GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_1684405_1	1123508.JH636441_gene3524	4.8e-34	124.0	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_28,HTH_32
k59_1684405_2	864069.MicloDRAFT_00002930	6.25e-47	158.0	COG3335@1|root,COG3335@2|Bacteria,1MXYQ@1224|Proteobacteria,2TSX4@28211|Alphaproteobacteria,1JYEX@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_567919_2	543728.Vapar_4545	6.76e-18	80.5	2F7FM@1|root,33ZWD@2|Bacteria,1NYCD@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_333896_1	631362.Thi970DRAFT_04426	8.66e-29	109.0	2E5RU@1|root,330GE@2|Bacteria,1N9AB@1224|Proteobacteria,1SENF@1236|Gammaproteobacteria,1WZFN@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_293267_1	329726.AM1_2070	1.71e-36	136.0	COG0616@1|root,COG0616@2|Bacteria,1G6XQ@1117|Cyanobacteria	1117|Cyanobacteria	OU	Peptidase family S49	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_1033510_1	367299.JOEE01000003_gene2871	0.00036	42.0	COG3508@1|root,COG3508@2|Bacteria,2GKZV@201174|Actinobacteria,4FET6@85021|Intrasporangiaceae	201174|Actinobacteria	Q	homogentisate 12-dioxygenase	hmgA	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
k59_1033510_2	367299.JOEE01000003_gene2870	6.85e-54	169.0	COG2127@1|root,COG2127@2|Bacteria,2IQ3Z@201174|Actinobacteria,4FH04@85021|Intrasporangiaceae	201174|Actinobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
k59_1623486_1	177437.HRM2_20800	9.04e-58	194.0	COG3385@1|root,COG3385@2|Bacteria,1R8CS@1224|Proteobacteria,42P9F@68525|delta/epsilon subdivisions,2WKTA@28221|Deltaproteobacteria,2MJAY@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_2
k59_1565289_1	1121028.ARQE01000009_gene4090	1.47e-28	111.0	COG0784@1|root,COG0784@2|Bacteria,1MX3Y@1224|Proteobacteria,2TT2R@28211|Alphaproteobacteria,2PIYB@255475|Aurantimonadaceae	28211|Alphaproteobacteria	T	cheY-homologous receiver domain	phyR	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Sigma70_r4_2
k59_1565289_2	583355.Caka_2206	7.42e-11	63.2	COG3431@1|root,COG3431@2|Bacteria,46T5K@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM BLUF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BLUF
k59_1150637_2	1187851.A33M_2077	1.83e-26	102.0	COG1247@1|root,COG1247@2|Bacteria,1QU6B@1224|Proteobacteria,2TW1F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,FR47
k59_1797784_1	2340.JV46_26900	2.02e-40	151.0	COG0834@1|root,COG0834@2|Bacteria,1N315@1224|Proteobacteria,1T21D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
k59_567934_1	1304865.JAGF01000001_gene1917	8.68e-78	259.0	COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria,4F0ID@85016|Cellulomonadaceae	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1106639_1	395493.BegalDRAFT_2126	9.54e-74	230.0	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,1RNDX@1236|Gammaproteobacteria,460CM@72273|Thiotrichales	72273|Thiotrichales	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_1623496_1	399795.CtesDRAFT_PD2235	5.79e-38	136.0	COG2353@1|root,COG2353@2|Bacteria,1N3P9@1224|Proteobacteria,2VSMB@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
k59_744835_2	1408304.JAHA01000019_gene2472	6.4e-12	68.9	COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,4BW1P@830|Butyrivibrio	186801|Clostridia	LU	DNA recombination-mediator protein A	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_1033531_1	604354.TSIB_1171	8.31e-13	69.7	COG4902@1|root,arCOG03957@2157|Archaea,2XX05@28890|Euryarchaeota,243Z0@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein domain (DUF2202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2202
k59_1033531_2	1122194.AUHU01000003_gene2050	2.32e-18	85.9	COG3122@1|root,COG3122@2|Bacteria,1N15V@1224|Proteobacteria,1S5V0@1236|Gammaproteobacteria,467D6@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	yaiL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K09912	-	-	-	-	ko00000	-	-	iECW_1372.ECW_m0432,iWFL_1372.ECW_m0432	DUF2058
k59_1033531_3	506534.Rhein_2509	7.5e-09	55.5	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,1RR4R@1236|Gammaproteobacteria,1WWMM@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM channel protein, hemolysin III family	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
k59_1797809_1	1033737.CAEV01000112_gene3436	1.36e-38	135.0	COG0778@1|root,COG0778@2|Bacteria,1V4DP@1239|Firmicutes,24HBZ@186801|Clostridia,36I36@31979|Clostridiaceae	186801|Clostridia	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_1449470_1	1333856.L686_13775	6.58e-71	238.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RWZA@1236|Gammaproteobacteria,1Z031@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	L	DEAD DEAH box helicase	lhr2	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_744860_1	1122603.ATVI01000006_gene503	7.19e-61	199.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1X3US@135614|Xanthomonadales	135614|Xanthomonadales	NU	Pilus assembly protein	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_509486_1	105559.Nwat_1098	1.03e-135	410.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales	135613|Chromatiales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1515211_1	1122602.ATXP01000012_gene1750	8.15e-22	97.8	COG3206@1|root,COG3206@2|Bacteria,2GPMH@201174|Actinobacteria	201174|Actinobacteria	M	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
k59_567975_1	935839.JAGJ01000003_gene1483	5.11e-111	348.0	COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,4F3RU@85017|Promicromonosporaceae	201174|Actinobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_567975_2	888056.HMPREF9062_1686	3.73e-38	134.0	COG0816@1|root,COG0816@2|Bacteria,2IQB0@201174|Actinobacteria,4D5SA@85005|Actinomycetales	201174|Actinobacteria	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	ruvX	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
k59_1214253_1	1234364.AMSF01000029_gene3400	1.02e-26	108.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1X2ZB@135614|Xanthomonadales	135614|Xanthomonadales	M	synthase	cfaA	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_1214253_2	1454004.AW11_02649	6.17e-07	52.4	COG1028@1|root,COG1028@2|Bacteria,1RDI1@1224|Proteobacteria,2VN3W@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase (SDR)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1623538_1	1232437.KL662054_gene5483	1.21e-51	172.0	COG3391@1|root,COG3391@2|Bacteria,1P6I0@1224|Proteobacteria,42Q47@68525|delta/epsilon subdivisions,2WJYF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Quinohemoprotein amine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1214257_1	396588.Tgr7_2233	1.87e-22	90.1	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,1S93F@1236|Gammaproteobacteria,1WYUJ@135613|Chromatiales	135613|Chromatiales	S	Tol-Pal system-associated acyl-CoA thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
k59_1214257_2	314285.KT71_07609	5.49e-115	339.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1J4F2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_157979_1	1380355.JNIJ01000041_gene5230	3.41e-230	660.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,3JUJP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
k59_1281069_1	338966.Ppro_0458	1.27e-08	57.0	COG2801@1|root,COG2801@2|Bacteria,1MUSB@1224|Proteobacteria,43AFH@68525|delta/epsilon subdivisions,2X5V7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1281069_2	338966.Ppro_1321	1.68e-80	248.0	COG3267@1|root,COG3267@2|Bacteria,1Q4DA@1224|Proteobacteria,42YYB@68525|delta/epsilon subdivisions,2WU9J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
k59_626787_2	471853.Bcav_2356	7.77e-65	208.0	COG0061@1|root,COG0061@2|Bacteria,2GKM2@201174|Actinobacteria	201174|Actinobacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006797,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_293358_1	994479.GL877879_gene4555	3.17e-67	218.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4DXAH@85010|Pseudonocardiales	201174|Actinobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL1	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_157981_1	1090318.ATTI01000001_gene1613	2.49e-34	130.0	COG2175@1|root,COG2175@2|Bacteria,1MWQ6@1224|Proteobacteria,2TQX1@28211|Alphaproteobacteria,2K7RQ@204457|Sphingomonadales	204457|Sphingomonadales	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_744906_1	1267533.KB906735_gene5037	5.27e-54	195.0	COG0339@1|root,COG0339@2|Bacteria,3Y2RS@57723|Acidobacteria,2JIV7@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase family M3	-	-	3.4.24.15	ko:K01392	ko04614,ko05143,map04614,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M3
k59_1033614_1	1267005.KB911262_gene3308	3.56e-56	190.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,3N6MU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_1565399_1	439235.Dalk_5017	5.71e-54	192.0	COG3852@1|root,COG5000@1|root,COG3852@2|Bacteria,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria,42Y7R@68525|delta/epsilon subdivisions,2WUPP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
k59_744914_2	472759.Nhal_3603	3.48e-77	239.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,1RQPK@1236|Gammaproteobacteria,1WX63@135613|Chromatiales	135613|Chromatiales	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
k59_1214303_1	103733.JNYO01000031_gene1513	1.14e-119	379.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2GN09@201174|Actinobacteria,4DX9H@85010|Pseudonocardiales	201174|Actinobacteria	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1281096_1	292415.Tbd_1072	1.79e-127	385.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2VS7B@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2
k59_158005_1	596324.TREVI0001_0368	2.71e-28	112.0	COG0846@1|root,COG0846@2|Bacteria,2J6BW@203691|Spirochaetes	203691|Spirochaetes	K	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k59_509554_1	983545.Glaag_1579	5.1e-21	90.9	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,46CUH@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K18244	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_638237_1	2340.JV46_05710	2.27e-28	112.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1J4QV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	stress-induced protein	yicC	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
k59_638237_2	614083.AWQR01000055_gene1978	4.16e-11	64.3	COG0515@1|root,COG2114@1|root,COG0515@2|Bacteria,COG2114@2|Bacteria,1PJRR@1224|Proteobacteria,2VHAU@28216|Betaproteobacteria,4AB4Y@80864|Comamonadaceae	28216|Betaproteobacteria	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	Pkinase
k59_229103_1	1255043.TVNIR_0568	4.77e-84	259.0	28I2K@1|root,2ZAEK@2|Bacteria,1R9HK@1224|Proteobacteria,1SJV2@1236|Gammaproteobacteria,1X001@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_638259_1	1121403.AUCV01000002_gene604	4.13e-110	324.0	COG1638@1|root,COG1638@2|Bacteria,1NJX4@1224|Proteobacteria,42QE0@68525|delta/epsilon subdivisions,2WP8A@28221|Deltaproteobacteria,2MNDU@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_346459_1	402881.Plav_2522	1.82e-59	192.0	COG0492@1|root,COG0492@2|Bacteria,1MW14@1224|Proteobacteria,2TSKU@28211|Alphaproteobacteria,1JPUP@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	L-lysine 6-monooxygenase (NADPH-requiring)	MA20_08170	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
k59_346459_2	1333998.M2A_1278	1.55e-17	78.2	COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,2U97J@28211|Alphaproteobacteria,4BQTR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	fdx	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
k59_806341_1	78245.Xaut_1383	2.68e-50	176.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria,3EYHN@335928|Xanthobacteraceae	28211|Alphaproteobacteria	H	Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_1754048_1	1217718.ALOU01000016_gene3160	8.25e-25	106.0	COG0786@1|root,COG0786@2|Bacteria,1MVBC@1224|Proteobacteria,2VJ2C@28216|Betaproteobacteria,1JZQ0@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes the sodium-dependent transport of glutamate	gltS	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
k59_462065_1	1123065.ATWL01000002_gene1758	3.8e-97	302.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria	201174|Actinobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2155c	AlaDh_PNT_C,Mur_ligase_C,Mur_ligase_M
k59_876304_1	380394.Lferr_1795	8.95e-28	110.0	COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,1S0KH@1236|Gammaproteobacteria,2NCCA@225057|Acidithiobacillales	225057|Acidithiobacillales	O	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_758206_1	1157490.EL26_17490	1.63e-31	125.0	COG0667@1|root,COG0667@2|Bacteria,1V53W@1239|Firmicutes,4HTG5@91061|Bacilli	91061|Bacilli	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1754062_1	1306406.ASHX01000002_gene5245	8.1e-95	290.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria	201174|Actinobacteria	M	Capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
k59_1161978_2	502025.Hoch_0839	2.01e-106	318.0	COG4653@1|root,COG4653@2|Bacteria,1Q2PX@1224|Proteobacteria,438B9@68525|delta/epsilon subdivisions,2X3KG@28221|Deltaproteobacteria,2YWF5@29|Myxococcales	28221|Deltaproteobacteria	S	Phage capsid family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_capsid
k59_1698315_1	335543.Sfum_3291	4.04e-78	249.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MQ86@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1579651_1	926566.Terro_2393	5.42e-54	185.0	COG2204@1|root,COG2204@2|Bacteria,3Y33M@57723|Acidobacteria,2JHW9@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1579651_2	234267.Acid_4169	4.46e-34	131.0	COG5000@1|root,COG5000@2|Bacteria,3Y2TD@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_1579653_1	1713.JOFV01000002_gene489	2.91e-104	315.0	COG0055@1|root,COG0055@2|Bacteria,2GIY6@201174|Actinobacteria,4F0TY@85016|Cellulomonadaceae	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_229158_1	1123400.KB904780_gene1794	9.03e-11	62.4	COG2995@1|root,COG2995@2|Bacteria,1NA1F@1224|Proteobacteria,1SERF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Paraquat-inducible protein A	-	-	-	-	-	-	-	-	-	-	-	-	PqiA
k59_229158_2	768671.ThimaDRAFT_3179	1.2e-51	166.0	2DCQX@1|root,2ZF0J@2|Bacteria,1PB0M@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1228067_1	1121438.JNJA01000003_gene3168	4.26e-53	187.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2M9WR@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.6	ko:K01535,ko:K12955	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.24,3.A.3.3	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_1161986_1	103733.JNYO01000036_gene2873	1.01e-13	74.3	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,4E536@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.362	ko:K15944	ko01057,ko01130,map01057,map01130	M00781	R06677,R06682,R09329	RC00234	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
k59_1579660_1	1121405.dsmv_0535	1.04e-76	257.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIWK@28221|Deltaproteobacteria,2MI9Z@213118|Desulfobacterales	28221|Deltaproteobacteria	CP	Domain of unknown function (DUF4040)	mrpA	-	-	ko:K05559,ko:K05565	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
k59_229174_1	1121413.JMKT01000014_gene2486	1.9e-08	60.1	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42M5C@68525|delta/epsilon subdivisions,2WJ54@28221|Deltaproteobacteria,2M8IF@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Lytic transglycosylase catalytic	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_1161996_1	1123401.JHYQ01000013_gene673	2.42e-43	150.0	COG4902@1|root,COG4902@2|Bacteria,1RHUF@1224|Proteobacteria,1S5D0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein domain (DUF2202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2202
k59_1754097_1	987059.RBXJA2T_06920	5.84e-32	114.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2VSMS@28216|Betaproteobacteria,1KM2P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	FG	Scavenger mRNA decapping enzyme C-term binding	hitA	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	DcpS_C,HIT
k59_1754097_2	742821.HMPREF9464_01752	1.31e-16	74.3	COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,2VVT6@28216|Betaproteobacteria,4PRCD@995019|Sutterellaceae	28216|Betaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_1637340_2	1121013.P873_02170	3.43e-12	72.8	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1X43X@135614|Xanthomonadales	135614|Xanthomonadales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
k59_579421_1	1142394.PSMK_03390	3.72e-67	228.0	COG0567@1|root,COG0567@2|Bacteria,2IWRF@203682|Planctomycetes	203682|Planctomycetes	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1049313_1	1453501.JELR01000002_gene970	1.27e-56	192.0	COG4974@1|root,COG4974@2|Bacteria,1NY1A@1224|Proteobacteria,1RN33@1236|Gammaproteobacteria,463XP@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG3436 Transposase and inactivated derivatives	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_1808828_1	717785.HYPMC_4549	2.1e-87	278.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2TRJS@28211|Alphaproteobacteria,3N67J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_1579717_1	1038859.AXAU01000030_gene6762	1.07e-105	318.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,3JVHX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_698429_1	590998.Celf_1787	1.36e-74	243.0	COG1994@1|root,COG1994@2|Bacteria,2GJBZ@201174|Actinobacteria,4F151@85016|Cellulomonadaceae	201174|Actinobacteria	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50,Peptidase_M50B
k59_638360_1	105559.Nwat_2821	9.85e-15	79.0	COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,1RPD2@1236|Gammaproteobacteria,1WXID@135613|Chromatiales	135613|Chromatiales	S	doubled CXXCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Paired_CXXCH_1,TPR_19,TPR_8
k59_1579728_1	1279009.ADICEAN_00034	4.29e-57	185.0	2C8PG@1|root,32RMK@2|Bacteria,4P5DF@976|Bacteroidetes,47VYD@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1162036_1	196627.cg0418	2.63e-79	247.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,22M5Y@1653|Corynebacteriaceae	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	epsN	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
k59_1162036_2	106370.Francci3_3473	2.42e-12	68.2	COG1086@1|root,COG1086@2|Bacteria,2GIXM@201174|Actinobacteria,4ERU6@85013|Frankiales	201174|Actinobacteria	GM	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
k59_758296_1	1144305.PMI02_04518	5.97e-08	57.8	COG3515@1|root,COG3515@2|Bacteria,1NRMK@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_638362_1	243233.MCA3026	9.19e-45	154.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1XEJ6@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF1732)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
k59_346562_1	102125.Xen7305DRAFT_00047640	9.77e-72	230.0	COG0583@1|root,COG0583@2|Bacteria,1G1DX@1117|Cyanobacteria,3VJ98@52604|Pleurocapsales	1117|Cyanobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_462149_1	493475.GARC_1987	9.43e-43	152.0	COG1136@1|root,COG1136@2|Bacteria,1QT8W@1224|Proteobacteria,1S43H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_462149_2	118173.KB235914_gene2486	9.7e-31	119.0	COG0577@1|root,COG0577@2|Bacteria,1G20M@1117|Cyanobacteria,1H7PU@1150|Oscillatoriales	1117|Cyanobacteria	V	DevC protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_171358_1	765910.MARPU_04845	5.82e-57	196.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1WX0K@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5
k59_1579758_2	870187.Thini_1880	8.64e-28	110.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RQJD@1236|Gammaproteobacteria,45ZP5@72273|Thiotrichales	72273|Thiotrichales	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_698452_1	1155714.KB891993_gene5603	4.71e-26	112.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria	201174|Actinobacteria	P	Sulfate transporter	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1162066_1	1454004.AW11_01219	4.66e-32	128.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,2VNED@28216|Betaproteobacteria,1KQ0H@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	L	DNA polymerase III	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
k59_806469_1	305700.B447_16859	3.38e-52	170.0	COG2209@1|root,COG2209@2|Bacteria,1R33S@1224|Proteobacteria,2WIF5@28216|Betaproteobacteria,2KZQY@206389|Rhodocyclales	206389|Rhodocyclales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrE	-	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
k59_806469_2	754477.Q7C_1708	2.68e-94	281.0	COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,4602B@72273|Thiotrichales	72273|Thiotrichales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrD	-	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
k59_806469_3	1245471.PCA10_21290	1.43e-79	248.0	COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,1RR85@1236|Gammaproteobacteria,1YCZ0@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrC	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
k59_806469_4	28115.HR11_00810	6.51e-07	50.4	COG4658@1|root,COG4658@2|Bacteria,4NFGW@976|Bacteroidetes,2FMD0@200643|Bacteroidia,22W1H@171551|Porphyromonadaceae	976|Bacteroidetes	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrB	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
k59_1462635_1	1046724.KB889827_gene2658	1.7e-87	269.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,464DI@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Displays ATPase and GTPase activities	rapZ	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
k59_1462635_2	2340.JV46_25920	1.31e-19	87.0	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,1S02U@1236|Gammaproteobacteria,1J7PM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
k59_579500_1	314278.NB231_07942	4e-151	442.0	COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales	135613|Chromatiales	P	Belongs to the sulfate adenylyltransferase family	cysC	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
k59_1462652_1	637905.SVI_3141	1.15e-33	129.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria,2Q9VE@267890|Shewanellaceae	1236|Gammaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1228211_1	765912.Thimo_1624	2.78e-33	123.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria,1WX1R@135613|Chromatiales	135613|Chromatiales	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_698495_2	1049564.TevJSym_as00320	4.83e-06	48.5	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria,1J5TZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	COG0501 Zn-dependent protease with chaperone function	Z012_09445	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_1462658_1	1279019.ARQK01000043_gene2143	8.71e-13	70.9	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,LysM
k59_1579826_1	42565.FP66_06770	1.24e-51	178.0	COG2334@1|root,COG2334@2|Bacteria,1QV5C@1224|Proteobacteria,1T293@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Ecdysteroid kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_1579826_2	1042375.AFPL01000046_gene1970	6.83e-44	151.0	COG0189@1|root,COG0189@2|Bacteria,1PJQE@1224|Proteobacteria,1RZ2S@1236|Gammaproteobacteria,46AC2@72275|Alteromonadaceae	1236|Gammaproteobacteria	HJ	Prokaryotic glutathione synthetase, ATP-grasp domain	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
k59_1810902_2	1198232.CYCME_1694	2.14e-47	161.0	COG2928@1|root,COG2928@2|Bacteria,1R79M@1224|Proteobacteria,1S6CC@1236|Gammaproteobacteria,46131@72273|Thiotrichales	72273|Thiotrichales	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
k59_1810902_3	1286106.MPL1_07443	2.73e-80	243.0	COG3040@1|root,COG3040@2|Bacteria,1RIKA@1224|Proteobacteria,1T0AA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Outer Membrane Lipoprotein	blc4	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
k59_464504_1	713587.THITH_16310	3.71e-96	310.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales	135613|Chromatiales	E	Vitamin B12 dependent methionine synthase activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_760592_4	768066.HELO_3398	4.94e-23	97.8	COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,1XHF7@135619|Oceanospirillales	135619|Oceanospirillales	J	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue	prmB	-	2.1.1.298	ko:K07320	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03009	-	-	-	MTS
k59_1639128_1	1313172.YM304_08310	5.46e-66	211.0	COG0092@1|root,COG0092@2|Bacteria,2GKF1@201174|Actinobacteria,4CMU9@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_878921_1	518766.Rmar_2736	6.36e-83	249.0	COG0225@1|root,COG0225@2|Bacteria,4NMAJ@976|Bacteroidetes,1FJ77@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_1810911_1	1283300.ATXB01000001_gene1158	1.64e-57	202.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1XE0B@135618|Methylococcales	135618|Methylococcales	H	Vitamin B12 dependent methionine synthase, activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_1756081_1	243233.MCA2886	1.91e-76	230.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,1XEZG@135618|Methylococcales	135618|Methylococcales	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0006139,GO:0006165,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:1901360	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
k59_1756081_2	1036674.A28LD_1748	3.11e-08	54.3	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,2QFRC@267893|Idiomarinaceae	1236|Gammaproteobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_1639130_1	1049564.TevJSym_ad01480	3.47e-81	247.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,1RNKT@1236|Gammaproteobacteria,1J5U3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO1391,iSDY_1059.SDY_2348	Cytidylate_kin
k59_1230406_1	1234364.AMSF01000059_gene950	1.82e-53	173.0	COG1522@1|root,COG1522@2|Bacteria,1RJK0@1224|Proteobacteria,1S6HD@1236|Gammaproteobacteria,1X6QR@135614|Xanthomonadales	135614|Xanthomonadales	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
k59_1405202_1	686340.Metal_2027	1.58e-79	242.0	COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,1SAHT@1236|Gammaproteobacteria,1XGEW@135618|Methylococcales	135618|Methylococcales	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_760617_1	502025.Hoch_1418	9.87e-40	150.0	COG0515@1|root,COG1672@1|root,COG2319@1|root,COG0515@2|Bacteria,COG1672@2|Bacteria,COG2319@2|Bacteria,1MWJA@1224|Proteobacteria,42P8D@68525|delta/epsilon subdivisions,2WMH1@28221|Deltaproteobacteria,2Z33N@29|Myxococcales	28221|Deltaproteobacteria	T	SMART serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,CHAT,Pkinase,WD40
k59_878942_1	1463926.JOCA01000006_gene3775	0.000172	51.2	COG1075@1|root,COG1672@1|root,COG1075@2|Bacteria,COG1672@2|Bacteria,2I3YT@201174|Actinobacteria	201174|Actinobacteria	E	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
k59_231436_1	383372.Rcas_2044	2.95e-104	309.0	COG2376@1|root,COG2376@2|Bacteria,2G80E@200795|Chloroflexi,376JR@32061|Chloroflexia	32061|Chloroflexia	G	TIGRFAM dihydroxyacetone kinase, DhaK subunit	-	-	2.7.1.121	ko:K05878	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak1
k59_348727_1	765911.Thivi_2495	6.48e-44	153.0	COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,1RZQ2@1236|Gammaproteobacteria,1WXSM@135613|Chromatiales	135613|Chromatiales	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_1756109_1	445970.ALIPUT_02134	3.59e-22	94.7	COG0320@1|root,COG0320@2|Bacteria,4NEB5@976|Bacteroidetes,2FNBV@200643|Bacteroidia,22U09@171550|Rikenellaceae	976|Bacteroidetes	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_1756109_2	637911.AM305_03890	1.3e-12	68.9	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1Y73F@135625|Pasteurellales	135625|Pasteurellales	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_296965_1	323261.Noc_0361	8.16e-32	115.0	COG1310@1|root,COG1310@2|Bacteria,1RJSM@1224|Proteobacteria,1S86M@1236|Gammaproteobacteria,1X21I@135613|Chromatiales	135613|Chromatiales	S	SMART Mov34 MPN PAD-1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
k59_296965_2	426114.THI_0968	2.49e-16	77.8	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2VI1U@28216|Betaproteobacteria,1KJSX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	ThiF family	thiF	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
k59_1177408_1	1123367.C666_01840	5.75e-70	219.0	COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,2VN3A@28216|Betaproteobacteria,2KVAG@206389|Rhodocyclales	206389|Rhodocyclales	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	nnr	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_1118363_1	926560.KE387023_gene1701	2.16e-11	70.5	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria	2|Bacteria	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,DUF3365,GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_1824797_1	1141519.H6VUA1_9CAUD	3.64e-07	49.7	4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses  no RNA stage,4QPDE@28883|Caudovirales,4QNBQ@10744|Podoviridae	10744|Podoviridae	S	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_472955_1	1415779.JOMH01000001_gene1879	1.15e-05	48.1	COG0705@1|root,COG0705@2|Bacteria,1N8NS@1224|Proteobacteria,1SD4M@1236|Gammaproteobacteria,1X8MS@135614|Xanthomonadales	135614|Xanthomonadales	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
k59_472955_2	391625.PPSIR1_24049	3.45e-36	132.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,4346P@68525|delta/epsilon subdivisions,2X204@28221|Deltaproteobacteria,2YUUQ@29|Myxococcales	28221|Deltaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_1529446_2	875328.JDM601_1266	1.01e-59	207.0	COG1196@1|root,COG1196@2|Bacteria,2GK6F@201174|Actinobacteria	201174|Actinobacteria	D	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	SbcCD_C
k59_296978_1	1121405.dsmv_0420	2.31e-81	268.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,42MVK@68525|delta/epsilon subdivisions,2WKEN@28221|Deltaproteobacteria,2MIWJ@213118|Desulfobacterales	28221|Deltaproteobacteria	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_4497_1	1247024.JRLH01000016_gene1680	0.000476	43.1	2EMPC@1|root,33FBT@2|Bacteria,1QNQV@1224|Proteobacteria,1SI44@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1824814_1	265072.Mfla_0104	1.19e-67	236.0	2E3AM@1|root,32YA4@2|Bacteria,1NE7S@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1296720_1	1114970.PSF113_2423	5.58e-43	152.0	COG1052@1|root,COG1052@2|Bacteria,1MWID@1224|Proteobacteria,1SZRG@1236|Gammaproteobacteria,1YMYK@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_1588042_1	1318628.MARLIPOL_13019	8.66e-21	89.0	COG1595@1|root,COG1595@2|Bacteria,1R9ZN@1224|Proteobacteria,1S27W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigV	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1412277_1	1049564.TevJSym_aw00120	7.75e-117	355.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1J5XD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	dsrL	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,Fer4_9,NADH_4Fe-4S,Pyr_redox_2
k59_1705793_1	332101.JIBU02000005_gene356	0.000182	49.7	COG0535@1|root,COG0535@2|Bacteria,1TPZ4@1239|Firmicutes,249UR@186801|Clostridia,36QAS@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF3641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
k59_649116_1	1116375.VEJY3_22926	3.93e-16	75.1	2A022@1|root,30N4C@2|Bacteria,1PU9F@1224|Proteobacteria,1SCMU@1236|Gammaproteobacteria,1XYCX@135623|Vibrionales	135623|Vibrionales	S	Domain of unknown function (DUF1840)	VPA1132	-	-	-	-	-	-	-	-	-	-	-	DUF1840
k59_885707_1	953739.SVEN_2876	2.54e-24	109.0	COG3291@1|root,COG3291@2|Bacteria,2GJR2@201174|Actinobacteria	201174|Actinobacteria	S	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9
k59_1060379_1	795666.MW7_2754	1.15e-64	226.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,1K0D0@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
k59_63878_1	761193.Runsl_4079	5e-15	79.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,47K19@768503|Cytophagia	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_63878_2	1123255.JHYS01000017_gene1405	0.000527	50.4	COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,2VJAC@28216|Betaproteobacteria,4AAHF@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
k59_357380_1	1047013.AQSP01000144_gene928	7.54e-20	91.7	COG3533@1|root,COG3533@2|Bacteria,2NNW0@2323|unclassified Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	F5_F8_type_C,Glyco_hydro_127
k59_1588051_1	1122622.ATWJ01000012_gene1044	2.52e-28	110.0	COG2120@1|root,COG2120@2|Bacteria,2H2NY@201174|Actinobacteria,4FF2U@85021|Intrasporangiaceae	201174|Actinobacteria	S	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics	mca	GO:0003674,GO:0005488,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010126,GO:0010127,GO:0016137,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051186,GO:0071704,GO:0098754,GO:1901135,GO:1901657	3.5.1.115	ko:K18455	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
k59_1001726_2	1442599.JAAN01000035_gene723	9.71e-30	112.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1RMIZ@1236|Gammaproteobacteria,1X3QC@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulator	clp	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0017076,GO:0019001,GO:0019219,GO:0019222,GO:0030551,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032561,GO:0035438,GO:0036094,GO:0043167,GO:0043168,GO:0046983,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	Crp,HTH_Crp_2,cNMP_binding
k59_1298090_1	199310.c2268	7.66e-58	196.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,3XPGP@561|Escherichia	1236|Gammaproteobacteria	F	Belongs to the pyruvate kinase family	pykA	GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	e_coli_core.b1854,iAF1260.b1854,iB21_1397.B21_01813,iBWG_1329.BWG_1668,iEC042_1314.EC042_2021,iECBD_1354.ECBD_1784,iECB_1328.ECB_01825,iECDH10B_1368.ECDH10B_1995,iECDH1ME8569_1439.ECDH1ME8569_1801,iECD_1391.ECD_01825,iECO103_1326.ECO103_2044,iECO111_1330.ECO111_2362,iECO26_1355.ECO26_2692,iECUMN_1333.ECUMN_2152,iETEC_1333.ETEC_1887,iEcDH1_1363.EcDH1_1786,iEcE24377_1341.EcE24377A_2084,iEcHS_1320.EcHS_A1947,iEcSMS35_1347.EcSMS35_1332,iEcolC_1368.EcolC_1778,iG2583_1286.G2583_2306,iJO1366.b1854,iJR904.b1854,iSBO_1134.SBO_1162,iSSON_1240.SSON_1294,iSbBS512_1146.SbBS512_E2130,iUMNK88_1353.UMNK88_2326,iY75_1357.Y75_RS09740	PK,PK_C
k59_1237155_1	1441629.PCH70_05080	4.19e-85	280.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1Z6I8@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_1765059_1	472759.Nhal_0092	4.89e-115	360.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWNH@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_825800_1	1117943.SFHH103_02493	5.75e-30	122.0	COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQX3@28211|Alphaproteobacteria,4BNVY@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Multi-sensor signal transduction multi-kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_8,PAS_9,Pkinase
k59_825800_2	1033991.RLEG12_03340	5.21e-41	145.0	COG4566@1|root,COG4566@2|Bacteria,1QP7B@1224|Proteobacteria,2TUA4@28211|Alphaproteobacteria,4BBZI@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_65239_1	1502724.FF80_03428	3.18e-58	182.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2U749@28211|Alphaproteobacteria,3N6TQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
k59_65239_2	1150469.RSPPHO_01246	2.15e-32	121.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2TSI0@28211|Alphaproteobacteria,2JQSR@204441|Rhodospirillales	204441|Rhodospirillales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_945884_1	926550.CLDAP_12940	1.37e-19	86.7	COG0329@1|root,COG0329@2|Bacteria,2G6U3@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_945884_2	997296.PB1_11079	0.000742	43.5	COG0679@1|root,COG0679@2|Bacteria,1UEYG@1239|Firmicutes,4HD45@91061|Bacilli,1ZD15@1386|Bacillus	91061|Bacilli	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
k59_1588908_1	1049564.TevJSym_ac00740	4.02e-68	214.0	COG1317@1|root,COG1317@2|Bacteria,1NBN3@1224|Proteobacteria,1SWWK@1236|Gammaproteobacteria,1J6X3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	N	Flagellar biosynthesis type III secretory pathway protein	-	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
k59_1588908_2	1049564.TevJSym_ac00730	2.08e-60	199.0	COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,1RM9W@1236|Gammaproteobacteria,1J55H@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	COG1157 Flagellar biosynthesis type III secretory pathway ATPase	fliI	GO:0003674,GO:0005488,GO:0005515,GO:0042802	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1471873_1	1095769.CAHF01000014_gene2876	8.72e-56	196.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,472GD@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_358730_1	1449058.JQKT01000007_gene1472	1.16e-120	353.0	COG0341@1|root,COG0341@2|Bacteria,2GJRS@201174|Actinobacteria,4FMNG@85023|Microbacteriaceae	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_297919_1	987059.RBXJA2T_05423	2.33e-92	279.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,1KJVK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Phosphate transporter family	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_297919_2	864051.BurJ1DRAFT_3099	5.41e-07	49.7	COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,2VKF1@28216|Betaproteobacteria,1KK30@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_887056_1	1408813.AYMG01000039_gene2308	1.08e-54	193.0	COG0841@1|root,COG0841@2|Bacteria,4NGVM@976|Bacteroidetes,1IQ7W@117747|Sphingobacteriia	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1471880_1	765914.ThisiDRAFT_0197	5e-54	181.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1WX0P@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_1001739_1	670307.HYPDE_30343	1.05e-32	122.0	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,2TRC9@28211|Alphaproteobacteria,3N6PB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	MazG nucleotide pyrophosphohydrolase domain	mazG	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
k59_1001739_2	585423.KR49_00705	6.77e-05	46.6	COG4308@1|root,COG4308@2|Bacteria,1GDIJ@1117|Cyanobacteria,1H08T@1129|Synechococcus	1117|Cyanobacteria	K	Uncharacterized conserved protein (DUF2358)	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
k59_591428_1	1116472.MGMO_126c00230	2.11e-33	130.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,1RMB0@1236|Gammaproteobacteria,1XEPM@135618|Methylococcales	135618|Methylococcales	H	PFAM Mur ligase	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_1061367_1	743720.Psefu_4091	1.39e-71	236.0	COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,1RN9V@1236|Gammaproteobacteria,1YWNZ@136845|Pseudomonas putida group	1236|Gammaproteobacteria	C	UPF0313 protein	ygiQ	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
k59_1706694_1	1215092.PA6_020_00800	3.52e-99	298.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1YDF2@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_1471887_1	374847.Kcr_0325	1.83e-33	131.0	arCOG03462@1|root,arCOG03462@2157|Archaea	2157|Archaea	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_180376_1	1429046.RR21198_2053	8.4e-84	254.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4FV76@85025|Nocardiaceae	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_532642_1	670307.HYPDE_36813	2.92e-73	234.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,2TQJY@28211|Alphaproteobacteria,3N6FJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	MOFRL family	MA20_18630	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
k59_887087_2	590998.Celf_2455	1.01e-81	254.0	COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4F0RS@85016|Cellulomonadaceae	201174|Actinobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_887092_1	202956.BBNL01000031_gene181	2.55e-109	325.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,3NJ8E@468|Moraxellaceae	1236|Gammaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_0516	DHBP_synthase,GTP_cyclohydro2
k59_65286_1	268739.Nmlp_1437	6.38e-08	57.4	COG3316@1|root,arCOG02134@2157|Archaea,2XUVA@28890|Euryarchaeota	28890|Euryarchaeota	L	Transposase	-	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
k59_5712_2	765912.Thimo_2434	6.62e-71	234.0	COG1018@1|root,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,1T2FP@1236|Gammaproteobacteria,1WWXW@135613|Chromatiales	135613|Chromatiales	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2
k59_239655_1	1380354.JIAN01000006_gene1078	5.79e-23	95.5	COG0204@1|root,COG0204@2|Bacteria,2GKVA@201174|Actinobacteria,4F16D@85016|Cellulomonadaceae	201174|Actinobacteria	I	Phosphate acyltransferases	plsC2	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_239655_2	1304865.JAGF01000001_gene2814	2.88e-25	103.0	COG0240@1|root,COG0240@2|Bacteria,2GJSD@201174|Actinobacteria,4F1Q8@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM NAD-dependent glycerol-3-phosphate dehydrogenase domain protein	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_766881_1	279714.FuraDRAFT_3683	1.3e-127	372.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,2VHWH@28216|Betaproteobacteria,2KQ3R@206351|Neisseriales	206351|Neisseriales	H	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
k59_708766_1	1096756.ATKN01000010_gene483	1.76e-23	106.0	2DQWK@1|root,3393J@2|Bacteria,2IEMK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1354466_1	511145.b3463	1.25e-05	47.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,3XP97@561|Escherichia	1236|Gammaproteobacteria	D	Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring	ftsE	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0019897,GO:0019898,GO:0030554,GO:0031234,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_1354466_2	395493.BegalDRAFT_1376	5.17e-34	129.0	COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,460I1@72273|Thiotrichales	72273|Thiotrichales	D	Part of the ABC transporter FtsEX involved in cellular division	-	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
k59_825842_1	1122599.AUGR01000017_gene2985	2.36e-75	241.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1XHQX@135619|Oceanospirillales	135619|Oceanospirillales	M	N-acetylmuramoyl-L-alanine amidase	amiB	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,LysM
k59_297968_1	408672.NBCG_04015	3.37e-64	209.0	COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria,4DP1E@85009|Propionibacteriales	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
k59_1530387_1	395493.BegalDRAFT_1523	5.82e-15	75.9	2952G@1|root,2ZSF9@2|Bacteria,1NFKJ@1224|Proteobacteria,1S5Q0@1236|Gammaproteobacteria,4636E@72273|Thiotrichales	72273|Thiotrichales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1119163_1	1304865.JAGF01000001_gene2784	2.37e-85	268.0	COG0119@1|root,COG0119@2|Bacteria,2GKYT@201174|Actinobacteria,4F102@85016|Cellulomonadaceae	201174|Actinobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA2	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_358811_1	1267005.KB911258_gene633	7.95e-165	481.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria,3N6H6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_945977_1	998088.B565_0130	2.27e-90	278.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria,1Y586@135624|Aeromonadales	135624|Aeromonadales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.113	ko:K12256	ko00330,ko01100,map00330,map01100	-	R08714	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_708778_1	2340.JV46_19080	6.41e-178	523.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,1J8A6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_415009_1	1366046.HIMB11_02415	3.63e-93	283.0	COG0683@1|root,COG0683@2|Bacteria,1PF5W@1224|Proteobacteria,2V88D@28211|Alphaproteobacteria,3ZIK4@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1298196_1	710696.Intca_1201	3.03e-141	403.0	COG0479@1|root,COG0479@2|Bacteria,2GJPS@201174|Actinobacteria,4FEDH@85021|Intrasporangiaceae	201174|Actinobacteria	C	succinate dehydrogenase	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
k59_1298196_2	590998.Celf_2877	4.9e-69	215.0	COG1514@1|root,COG1514@2|Bacteria,2GRF0@201174|Actinobacteria,4F1AH@85016|Cellulomonadaceae	201174|Actinobacteria	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
k59_1298196_3	1043493.BBLU01000008_gene451	1.72e-53	179.0	COG0180@1|root,COG0180@2|Bacteria,2GJ9A@201174|Actinobacteria	201174|Actinobacteria	J	Tryptophanyl-tRNA synthetase	trpS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_1588970_1	1042876.PPS_2937	2.74e-77	248.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1YYF6@136845|Pseudomonas putida group	1236|Gammaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	yngI	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_1588970_2	572477.Alvin_3109	6.32e-24	95.5	COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,1S78U@1236|Gammaproteobacteria,1WVZ8@135613|Chromatiales	135613|Chromatiales	S	PFAM NnrU protein	-	-	-	-	-	-	-	-	-	-	-	-	NnrU
k59_239708_2	477184.KYC_19439	1.23e-70	215.0	2DB76@1|root,2Z7JZ@2|Bacteria,1R41X@1224|Proteobacteria,2VMX8@28216|Betaproteobacteria	28216|Betaproteobacteria	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
k59_1178381_1	1496688.ER33_14805	1.18e-68	224.0	COG5361@1|root,COG5361@2|Bacteria,1G1YW@1117|Cyanobacteria,22TKK@167375|Cyanobium	1117|Cyanobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_180426_2	1042876.PPS_2937	2.49e-31	122.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1YYF6@136845|Pseudomonas putida group	1236|Gammaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	yngI	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_127042_1	1385517.N800_06325	3.65e-27	113.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1RMA2@1236|Gammaproteobacteria,1X3KI@135614|Xanthomonadales	135614|Xanthomonadales	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
k59_596116_1	153948.NAL212_1293	1.87e-67	214.0	COG3677@1|root,COG3677@2|Bacteria,1R3ZS@1224|Proteobacteria,2WFCR@28216|Betaproteobacteria	1224|Proteobacteria	L	Transposase zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_1653529_2	1713.JOFV01000004_gene3442	7.46e-70	225.0	COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4F1WF@85016|Cellulomonadaceae	201174|Actinobacteria	M	Peptidase family M50	rip1	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
k59_1479126_2	1108045.GORHZ_150_00010	1.2e-21	92.4	arCOG07533@1|root,2ZF5I@2|Bacteria,2IMPX@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
k59_1833387_2	292415.Tbd_0567	2.29e-36	127.0	COG2010@1|root,COG2010@2|Bacteria,1N91W@1224|Proteobacteria,2WC80@28216|Betaproteobacteria,1KT7X@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Cytochrome c	-	-	-	ko:K17223	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	-
k59_1833387_3	388399.SSE37_10687	1.59e-16	84.0	COG3258@1|root,COG3474@1|root,COG3258@2|Bacteria,COG3474@2|Bacteria,1MZGS@1224|Proteobacteria,2UCUT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	cytochrome	soxD	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
k59_72342_1	713586.KB900536_gene2509	1.36e-80	254.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1WWMQ@135613|Chromatiales	135613|Chromatiales	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1359274_1	86416.Clopa_0515	4.32e-12	69.3	COG3381@1|root,COG3381@2|Bacteria,1VDIH@1239|Firmicutes,25DPM@186801|Clostridia,36W4M@31979|Clostridiaceae	186801|Clostridia	S	Nitrate reductase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
k59_1418753_1	313596.RB2501_07255	6.91e-24	99.8	COG3000@1|root,COG3000@2|Bacteria,4NEYE@976|Bacteroidetes,1HWTG@117743|Flavobacteriia	976|Bacteroidetes	I	Sterol desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_1418753_2	479433.Caci_7615	6.22e-22	96.3	COG0122@1|root,COG0122@2|Bacteria,2GP69@201174|Actinobacteria	201174|Actinobacteria	L	3-methyladenine DNA glycosylase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1305238_1	765911.Thivi_0249	6.07e-81	254.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1RQ0H@1236|Gammaproteobacteria,1WWQC@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
k59_72347_1	243233.MCA0768	3.45e-57	189.0	COG0167@1|root,COG0167@2|Bacteria,1MXER@1224|Proteobacteria,1RRTA@1236|Gammaproteobacteria,1XDK5@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_770984_1	56780.SYN_00004	1.27e-29	115.0	COG2979@1|root,COG2979@2|Bacteria,1R95E@1224|Proteobacteria,42WF3@68525|delta/epsilon subdivisions,2WS14@28221|Deltaproteobacteria,2MQY7@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF533)	-	-	-	-	-	-	-	-	-	-	-	-	DUF533
k59_1593635_1	768671.ThimaDRAFT_3697	3.54e-48	168.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,1RMCR@1236|Gammaproteobacteria,1WXCQ@135613|Chromatiales	135613|Chromatiales	P	PFAM NnrS family protein	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
k59_1123334_1	935863.AWZR01000001_gene1626	1.89e-07	57.4	COG3595@1|root,COG3595@2|Bacteria,1N10U@1224|Proteobacteria,1S8T2@1236|Gammaproteobacteria,1X5XN@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_72356_2	1116472.MGMO_30c00090	2.01e-27	102.0	COG0271@1|root,COG0271@2|Bacteria,1QCDN@1224|Proteobacteria,1THS7@1236|Gammaproteobacteria,1XFIA@135618|Methylococcales	135618|Methylococcales	T	Belongs to the BolA IbaG family	-	-	-	ko:K05527	-	-	-	-	ko00000,ko03000	-	-	-	BolA
k59_249141_1	1123065.ATWL01000011_gene71	4.71e-65	223.0	COG4581@1|root,COG4581@2|Bacteria,2GJSV@201174|Actinobacteria	201174|Actinobacteria	L	dead DEAH box helicase	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,DUF3516,Helicase_C
k59_420049_1	395495.Lcho_1773	8.24e-25	110.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2VIXC@28216|Betaproteobacteria,1KJ2I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Subtilase family	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_3_2,Big_3_3,Peptidase_S8
k59_185767_1	1379281.AVAG01000029_gene37	6.86e-104	321.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2WJ2N@28221|Deltaproteobacteria,2M7R9@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_1418770_1	1163398.AJJP01000105_gene1441	1.92e-07	58.5	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	Membrane	yhdP	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_953082_1	1043493.BBLU01000005_gene1928	2.02e-43	153.0	COG0596@1|root,COG0596@2|Bacteria,2GNFU@201174|Actinobacteria	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
k59_72360_1	1448139.AI20_07340	1.35e-23	99.8	COG1024@1|root,COG1024@2|Bacteria,1PJ4R@1224|Proteobacteria,1S2FJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	phaB	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_72360_2	765912.Thimo_1870	7.07e-91	278.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,1WWUF@135613|Chromatiales	135613|Chromatiales	S	PFAM Patatin	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_420051_1	1042375.AFPL01000035_gene2825	3.43e-150	441.0	COG1132@1|root,COG1132@2|Bacteria,1N1Z8@1224|Proteobacteria,1RPVC@1236|Gammaproteobacteria,4664T@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	ABC transporter transmembrane region	ygaD	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1769800_1	713586.KB900536_gene1579	2.77e-147	425.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1WWWF@135613|Chromatiales	135613|Chromatiales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_1769800_2	1234364.AMSF01000046_gene1983	7.98e-14	72.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1X37F@135614|Xanthomonadales	135614|Xanthomonadales	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	gltP	-	-	ko:K03309	-	-	-	-	ko00000	2.A.23	-	-	SDF
k59_185775_1	765911.Thivi_0061	8.84e-90	282.0	COG0589@1|root,COG0730@1|root,COG0589@2|Bacteria,COG0730@2|Bacteria,1NBKV@1224|Proteobacteria,1SHMY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Universal stress protein family	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE,Usp
k59_1068616_1	665942.HMPREF1022_03103	7.17e-07	54.3	COG0457@1|root,COG0457@2|Bacteria,1R438@1224|Proteobacteria,42PQ9@68525|delta/epsilon subdivisions,2WJ0C@28221|Deltaproteobacteria,2M83F@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	SMART Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_10,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
k59_537736_2	1385515.N791_09860	6.56e-43	145.0	COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,1S9CQ@1236|Gammaproteobacteria,1X79E@135614|Xanthomonadales	135614|Xanthomonadales	S	Copper amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF411
k59_537736_3	1163408.UU9_01304	2.82e-08	61.2	COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,1RMWB@1236|Gammaproteobacteria,1X4W4@135614|Xanthomonadales	135614|Xanthomonadales	P	Iron permease	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,FTR1
k59_478892_1	335283.Neut_0779	4.61e-51	175.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,37215@32003|Nitrosomonadales	28216|Betaproteobacteria	I	fatty acid desaturase	ole1	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	DDE_Tnp_ISL3,FA_desaturase
k59_537740_1	1267005.KB911259_gene3689	5.37e-65	213.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,3N63V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	ko:K21470,ko:K21572	-	-	-	-	ko00000,ko01002,ko01011,ko02000	8.A.46.1,8.A.46.3	-	-	PG_binding_1,YkuD
k59_365877_1	743720.Psefu_3624	7.22e-74	233.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1YWSQ@136845|Pseudomonas putida group	1236|Gammaproteobacteria	M	lytic murein transglycosylase B	mltB	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
k59_1711380_1	265729.GS18_0214580	3.67e-44	160.0	COG1169@1|root,COG1169@2|Bacteria,1TSRT@1239|Firmicutes,4H9K8@91061|Bacilli,1ZB3V@1386|Bacillus	91061|Bacilli	HQ	Isochorismate synthase	menF	GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	5.4.4.2	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU30830	Chorismate_bind
k59_1769807_2	710696.Intca_3377	1.99e-206	575.0	COG2141@1|root,COG2141@2|Bacteria,2GNR5@201174|Actinobacteria,4FET2@85021|Intrasporangiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1244184_1	1120956.JHZK01000006_gene659	4.09e-59	206.0	COG1429@1|root,COG1429@2|Bacteria,1MU5W@1224|Proteobacteria,2TQVD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases	bchH	-	6.6.1.1	ko:K03403	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	CobN-Mg_chel,DUF3479
k59_72391_1	765869.BDW_08065	8.64e-37	140.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2MTSI@213481|Bdellovibrionales,2WKBU@28221|Deltaproteobacteria	213481|Bdellovibrionales	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1833471_1	526222.Desal_3023	1.7e-31	113.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,42U7E@68525|delta/epsilon subdivisions,2WPZP@28221|Deltaproteobacteria,2MCH7@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
k59_714075_1	1401065.HMPREF2130_04910	4.99e-30	123.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,3T227@506|Alcaligenaceae	28216|Betaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_249227_1	1121405.dsmv_1960	4.54e-73	229.0	COG4866@1|root,COG4866@2|Bacteria,1RIUZ@1224|Proteobacteria,42P4H@68525|delta/epsilon subdivisions,2WPMI@28221|Deltaproteobacteria,2MM47@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Uncharacterised conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
k59_1535283_1	481448.Minf_1320	1.58e-08	55.1	COG0374@1|root,COG0374@2|Bacteria,46UEU@74201|Verrucomicrobia,37GFV@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	Nickel-dependent hydrogenase	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_1535283_2	1126627.BAWE01000006_gene6680	3.57e-57	187.0	COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,2TSH2@28211|Alphaproteobacteria,3JU3R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	b-type cytochrome subunit	hupC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
k59_249231_1	768671.ThimaDRAFT_1908	4.96e-60	194.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1S0BJ@1236|Gammaproteobacteria,1X2F4@135613|Chromatiales	135613|Chromatiales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_302801_1	263358.VAB18032_16970	1.08e-18	86.3	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria,4DCY5@85008|Micromonosporales	201174|Actinobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
k59_302801_2	1043493.BBLU01000002_gene1760	4.44e-32	120.0	arCOG07533@1|root,2ZF5I@2|Bacteria,2IMPX@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
k59_1068662_1	690850.Desaf_1699	3.05e-41	154.0	COG0493@1|root,COG2878@1|root,COG0493@2|Bacteria,COG2878@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2WIVF@28221|Deltaproteobacteria,2M9TK@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Fe-S cluster domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fer4,Fer4_20,Fer4_7,Pyr_redox_2
k59_953140_1	378806.STAUR_4195	1.31e-102	318.0	2DGYZ@1|root,2ZXTY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_249243_1	1175306.GWL_27460	3.35e-79	246.0	COG1052@1|root,COG1052@2|Bacteria,1RAWT@1224|Proteobacteria,2VRZN@28216|Betaproteobacteria,478YR@75682|Oxalobacteraceae	28216|Betaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_15612_1	225937.HP15_1714	7.1e-69	233.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,464XN@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_1244218_1	479434.Sthe_1093	1.15e-28	116.0	COG0366@1|root,COG0366@2|Bacteria,2G89J@200795|Chloroflexi,27XYW@189775|Thermomicrobia	189775|Thermomicrobia	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_303536_1	273068.TTE1498	4.36e-66	208.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,42EWH@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Ribulose-phosphate 3-epimerase	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_186587_1	1123257.AUFV01000008_gene562	7.78e-28	108.0	COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,1S3T3@1236|Gammaproteobacteria,1X6EE@135614|Xanthomonadales	135614|Xanthomonadales	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_186587_2	743721.Psesu_1710	0.000123	44.7	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,1X407@135614|Xanthomonadales	135614|Xanthomonadales	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_250694_2	1255043.TVNIR_0142	2.24e-26	102.0	2B9UG@1|root,3237D@2|Bacteria,1RIGI@1224|Proteobacteria,1S831@1236|Gammaproteobacteria,1WYI0@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_656207_1	84531.JMTZ01000111_gene1614	1.32e-36	140.0	COG3291@1|root,COG3291@2|Bacteria,1R7JK@1224|Proteobacteria,1S0UR@1236|Gammaproteobacteria,1X476@135614|Xanthomonadales	135614|Xanthomonadales	S	Metalloprotease, specifically cleaves on the N-terminal side of aspartyl, glutamyl and cysteic acid residues	-	-	-	-	-	-	-	-	-	-	-	-	Reprolysin_5
k59_1306384_1	1267005.KB911262_gene3339	1.27e-115	346.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,3N6I0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_1480332_1	1278078.G419_05677	2.37e-50	184.0	COG1330@1|root,COG1330@2|Bacteria,2GNVB@201174|Actinobacteria,4FVAG@85025|Nocardiaceae	201174|Actinobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity	recC	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
k59_250704_1	446471.Xcel_3370	3.51e-70	230.0	COG1167@1|root,COG1167@2|Bacteria,2GITW@201174|Actinobacteria,4F3CU@85017|Promicromonosporaceae	201174|Actinobacteria	EK	Aminotransferase class I and II	avtA	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
k59_186595_1	246200.SPO2716	3.23e-42	159.0	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_303541_1	472759.Nhal_0572	4.28e-124	365.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1WWAV@135613|Chromatiales	135613|Chromatiales	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_303541_2	743720.Psefu_3624	1.01e-83	260.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1YWSQ@136845|Pseudomonas putida group	1236|Gammaproteobacteria	M	lytic murein transglycosylase B	mltB	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
k59_771668_1	661478.OP10G_0632	7.46e-71	223.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
k59_1306398_1	572477.Alvin_0062	3.74e-32	121.0	28KIX@1|root,2Z9Y0@2|Bacteria,1R427@1224|Proteobacteria,1RRGI@1236|Gammaproteobacteria,1WX2J@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM Poly(R)-hydroxyalkanoic acid synthase, class III, PhaE subunit	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009058,GO:0016234,GO:0042618,GO:0042619,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0070088,GO:0071704,GO:1901440,GO:1901441,GO:1901576	-	-	-	-	-	-	-	-	-	-	PHA_synth_III_E
k59_1306398_2	572477.Alvin_0063	7.98e-19	85.1	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1WW4A@135613|Chromatiales	135613|Chromatiales	I	Belongs to the thiolase family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_17117_1	765913.ThidrDRAFT_2848	1.09e-135	395.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,1RMX0@1236|Gammaproteobacteria,1WW96@135613|Chromatiales	135613|Chromatiales	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	-	ko:K02474	ko00520,map00520	-	R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_1245300_2	1049564.TevJSym_ao00400	8.81e-149	430.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1J4PI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the GARS family	purD	GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01945,ko:K13713	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729	GARS_A,GARS_C,GARS_N
k59_656226_1	631362.Thi970DRAFT_03572	8.05e-05	46.6	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,1WW2G@135613|Chromatiales	135613|Chromatiales	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri,YfiO
k59_656226_2	572477.Alvin_0956	4.55e-46	154.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,1WYG6@135613|Chromatiales	135613|Chromatiales	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
k59_1424319_2	945543.VIBR0546_03730	1.45e-23	100.0	COG0069@1|root,COG3369@1|root,COG0069@2|Bacteria,COG3369@2|Bacteria,1MU7B@1224|Proteobacteria,1RP1C@1236|Gammaproteobacteria,1XSHA@135623|Vibrionales	135623|Vibrionales	E	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase,zf-CDGSH
k59_1189333_1	866776.HMPREF9321_0314	6.86e-14	75.1	COG0134@1|root,COG0135@1|root,COG0134@2|Bacteria,COG0135@2|Bacteria,1TR94@1239|Firmicutes,4H3U4@909932|Negativicutes	909932|Negativicutes	E	Belongs to the TrpC family	trpC	-	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PRAI
k59_1189333_2	314230.DSM3645_10972	5.34e-07	51.6	COG0134@1|root,COG0134@2|Bacteria,2IX3M@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
k59_960596_1	765912.Thimo_2223	5.69e-70	224.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,1RM84@1236|Gammaproteobacteria,1WWYX@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM lysine 2,3-aminomutase YodO family protein	-	-	5.4.3.2	ko:K01843,ko:K19810	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000,ko03012	-	-	-	Fer4_12,Fer4_14,Radical_SAM
k59_132611_1	1267535.KB906767_gene1214	4.35e-69	224.0	COG2433@1|root,COG2433@2|Bacteria,3Y7F1@57723|Acidobacteria	57723|Acidobacteria	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
k59_1251554_3	1045009.AFXQ01000002_gene1663	1.4e-70	220.0	COG4760@1|root,COG4760@2|Bacteria,2GNCK@201174|Actinobacteria,1W8ZB@1268|Micrococcaceae	201174|Actinobacteria	S	Bax inhibitor 1 like	-	-	-	-	-	-	-	-	-	-	-	-	BaxI_1
k59_1599012_1	472759.Nhal_1755	3.34e-79	250.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RPI1@1236|Gammaproteobacteria,1WWK2@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1716612_1	265072.Mfla_1518	1.2e-89	270.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2VHDG@28216|Betaproteobacteria,2KM0C@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
k59_1540687_1	626887.J057_08796	4.96e-27	110.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,465M4@72275|Alteromonadaceae	1236|Gammaproteobacteria	NT	COG0840 Methyl-accepting chemotaxis protein	pilJ	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	MCPsignal,PilJ
k59_660939_1	870967.VIS19158_08518	2.21e-29	127.0	COG2982@1|root,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,1RNPC@1236|Gammaproteobacteria,1XSPR@135623|Vibrionales	135623|Vibrionales	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
k59_1841013_1	1249627.D779_0228	6.87e-82	261.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_308074_1	351016.RAZWK3B_08551	2.71e-111	323.0	COG2801@1|root,COG2801@2|Bacteria,1MVQ9@1224|Proteobacteria,2TTHG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_901649_1	882082.SaccyDRAFT_3741	1.54e-177	518.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4DZ3D@85010|Pseudonocardiales	201174|Actinobacteria	L	Excinuclease ATPase subunit	uvrA2	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_601280_1	545695.TREAZ_0067	7.03e-80	266.0	COG3568@1|root,COG3568@2|Bacteria,2J6UY@203691|Spirochaetes	203691|Spirochaetes	S	GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
k59_601280_2	572480.Arnit_1248	2.13e-10	65.5	COG2995@1|root,COG2995@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_601280_3	765911.Thivi_0027	1.71e-64	212.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,1RM9Z@1236|Gammaproteobacteria,1WX87@135613|Chromatiales	135613|Chromatiales	S	PFAM Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_601280_4	1279038.KB907355_gene2110	8.42e-110	341.0	COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,2TSTX@28211|Alphaproteobacteria,2JRHX@204441|Rhodospirillales	204441|Rhodospirillales	Q	Paraquat-inducible protein B	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_1841018_1	1463881.KL591008_gene2102	1.44e-25	109.0	COG2124@1|root,COG2124@2|Bacteria,2HZR8@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome p450	cyp144A4	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K21200	-	-	-	-	ko00000,ko00199	-	-	-	p450
k59_1312820_1	1009370.ALO_04983	3.5e-12	69.3	COG0834@1|root,COG0834@2|Bacteria,1TQUG@1239|Firmicutes,4H1US@909932|Negativicutes	909932|Negativicutes	ET	Belongs to the bacterial solute-binding protein 3 family	glnH	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_1599030_1	266264.Rmet_3598	4.42e-75	242.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2VMQV@28216|Betaproteobacteria,1K01B@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Flavin-binding monooxygenase-like	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	FMO-like,K_oxygenase,Pyr_redox_3
k59_836642_1	1041159.AZUW01000007_gene5279	5.32e-50	176.0	COG1757@1|root,COG1757@2|Bacteria,1MVDF@1224|Proteobacteria,2TU82@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Na H antiporter	-	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
k59_660945_1	1268635.Loa_01510	3.72e-43	158.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1JCH1@118969|Legionellales	118969|Legionellales	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	yfcX	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_660945_2	76114.c1A212	2.59e-76	241.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VMHS@28216|Betaproteobacteria,2KUQ2@206389|Rhodocyclales	206389|Rhodocyclales	I	Belongs to the thiolase family	fadA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1659201_1	713586.KB900536_gene1556	4.23e-124	369.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,1WX9B@135613|Chromatiales	135613|Chromatiales	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	-	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Acetyltransf_1
k59_601284_1	761193.Runsl_0693	5.7e-56	192.0	COG2989@1|root,COG2989@2|Bacteria,4NH3J@976|Bacteroidetes,47MU1@768503|Cytophagia	976|Bacteroidetes	T	L,D-transpeptidase catalytic domain	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_1775888_1	1198232.CYCME_2355	4.31e-14	73.9	COG3746@1|root,COG3746@2|Bacteria,1Q6EB@1224|Proteobacteria,1TA7N@1236|Gammaproteobacteria,4620B@72273|Thiotrichales	72273|Thiotrichales	P	Phosphate-selective porin O and P	-	-	-	ko:K07221	-	-	-	-	ko00000,ko02000	1.B.5.1	-	-	Porin_O_P
k59_1775888_3	396588.Tgr7_1283	2.08e-34	123.0	COG5622@1|root,COG5622@2|Bacteria,1N6XP@1224|Proteobacteria,1SCD9@1236|Gammaproteobacteria,1WYG0@135613|Chromatiales	135613|Chromatiales	N	Host attachment protein	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach
k59_543737_1	1208321.D104_01400	8.4e-09	59.3	COG2974@1|root,COG2974@2|Bacteria,1MXPR@1224|Proteobacteria,1RMNN@1236|Gammaproteobacteria,1XK25@135619|Oceanospirillales	135619|Oceanospirillales	L	May be involved in recombination	rdgC	-	-	ko:K03554	-	-	-	-	ko00000,ko03400	-	-	-	RdgC
k59_543737_2	558884.JRGM01000138_gene840	2.56e-28	107.0	COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,1S9D9@1236|Gammaproteobacteria,1Y5RH@135624|Aeromonadales	135624|Aeromonadales	FG	HIT domain	-	-	-	-	-	-	-	-	-	-	-	-	HIT
k59_902750_1	56780.SYN_02257	4.75e-98	304.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,43AEI@68525|delta/epsilon subdivisions,2X5UC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Alpha amylase	-	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_961734_1	365528.KB891208_gene3105	2.28e-69	229.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria,4ERWZ@85013|Frankiales	201174|Actinobacteria	EQ	Hydantoinase/oxoprolinase N-terminal region	hyuA	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_374517_1	1049564.TevJSym_ad00120	9.22e-106	330.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1J4MP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_2160,iPC815.YPO2428	B3_4,B5,FDX-ACB,tRNA_bind
k59_80947_1	398720.MED217_12344	6.94e-56	194.0	COG3534@1|root,COG3534@2|Bacteria,4NECK@976|Bacteroidetes,1HZE1@117743|Flavobacteriia,2XI60@283735|Leeuwenhoekiella	2|Bacteria	G	Alpha-L-arabinofuranosidase C-terminus	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
k59_602114_1	411464.DESPIG_03023	1.11e-23	104.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,42MX3@68525|delta/epsilon subdivisions,2WKI4@28221|Deltaproteobacteria,2MA90@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Transglycosylase SLT domain	-	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
k59_1717432_1	347834.RHE_CH01159	6.65e-19	92.0	COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,4B72Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS,PAS_4,PAS_9
k59_720325_1	367299.JOEE01000009_gene279	4.04e-61	197.0	COG2365@1|root,COG2365@2|Bacteria,2GK28@201174|Actinobacteria,4FG0J@85021|Intrasporangiaceae	201174|Actinobacteria	T	protein tyrosine phosphatase	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	Y_phosphatase3
k59_1010968_4	246197.MXAN_1868	1.97e-158	478.0	COG5518@1|root,COG5518@2|Bacteria,1MYGZ@1224|Proteobacteria,43C68@68525|delta/epsilon subdivisions,2X4IR@28221|Deltaproteobacteria,2YZ3J@29|Myxococcales	28221|Deltaproteobacteria	S	Phage portal protein, PBSX family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_portal
k59_1010968_5	502025.Hoch_0835	2.3e-60	204.0	2EREN@1|root,33J06@2|Bacteria,1Q57T@1224|Proteobacteria,43A4Y@68525|delta/epsilon subdivisions,2X9T2@28221|Deltaproteobacteria,2YY32@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1487476_1	977880.RALTA_B1495	2.4e-202	591.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,1K6SR@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdhA1	-	1.17.1.9,1.17.99.7	ko:K00123,ko:K22015	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1659978_1	1123518.ARWI01000001_gene86	5.02e-33	121.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,1S3QR@1236|Gammaproteobacteria,460RC@72273|Thiotrichales	72273|Thiotrichales	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
k59_133407_1	177437.HRM2_02740	7.26e-12	65.5	COG0370@1|root,COG0370@2|Bacteria,1QWMI@1224|Proteobacteria,43BSF@68525|delta/epsilon subdivisions,2X739@28221|Deltaproteobacteria,2MI8F@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_308908_1	1828.JOKB01000053_gene5251	1.12e-52	176.0	COG3022@1|root,COG3022@2|Bacteria,2GJPM@201174|Actinobacteria,4FV98@85025|Nocardiaceae	201174|Actinobacteria	S	Belongs to the UPF0246 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:1901700	-	ko:K09861	-	-	-	-	ko00000	-	-	-	H2O2_YaaD
k59_1659979_1	28229.ND2E_2535	8.14e-36	133.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,1RMX0@1236|Gammaproteobacteria,2Q7WJ@267889|Colwelliaceae	1236|Gammaproteobacteria	M	PFAM UDP-glucose GDP-mannose dehydrogenase, UDP-glucose GDP-mannose dehydrogenase	wecC	-	5.1.3.14	ko:K01791,ko:K02474	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420,R06894	RC00290,RC00291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_1487488_1	1122622.ATWJ01000007_gene1661	4.68e-06	54.7	COG1674@1|root,COG1674@2|Bacteria,2GJBR@201174|Actinobacteria,4FF4U@85021|Intrasporangiaceae	201174|Actinobacteria	D	FtsK/SpoIIIE family	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FHA,FtsK_SpoIIIE,Yop-YscD_cpl
k59_24785_1	1304865.JAGF01000001_gene3053	1.81e-212	628.0	COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,2GKN1@201174|Actinobacteria,4F0EH@85016|Cellulomonadaceae	201174|Actinobacteria	CJ	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1659986_1	1123514.KB905899_gene834	1.35e-56	191.0	COG3746@1|root,COG3746@2|Bacteria,1R8Q0@1224|Proteobacteria,1S1UE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
k59_1541487_1	314278.NB231_08320	6.02e-79	241.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1WVZP@135613|Chromatiales	135613|Chromatiales	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_1717458_2	768671.ThimaDRAFT_3898	2.41e-90	265.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,1S25G@1236|Gammaproteobacteria,1WXZP@135613|Chromatiales	135613|Chromatiales	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
k59_484990_1	556269.ACDQ01000016_gene511	8.19e-27	101.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,2VR2R@28216|Betaproteobacteria,474C5@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
k59_720354_2	930169.B5T_03190	6.59e-18	87.8	COG4932@1|root,COG4932@2|Bacteria,1QVU9@1224|Proteobacteria	1224|Proteobacteria	M	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD,REJ
k59_258545_1	1123393.KB891327_gene309	1.34e-74	232.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2W93N@28216|Betaproteobacteria,1KTHC@119069|Hydrogenophilales	1224|Proteobacteria	Q	ubiE/COQ5 methyltransferase family	ubiE_1	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_837433_1	590998.Celf_0573	3.17e-76	245.0	COG0029@1|root,COG0029@2|Bacteria,2I2IJ@201174|Actinobacteria,4F13T@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16,2.4.2.19	ko:K00278,ko:K00767	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481,R03348	RC00006,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1842147_1	1291050.JAGE01000001_gene2855	7.92e-25	108.0	COG1053@1|root,COG1053@2|Bacteria,1TRE8@1239|Firmicutes,247TH@186801|Clostridia	186801|Clostridia	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1425119_1	765911.Thivi_0057	2.24e-155	449.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales	135613|Chromatiales	P	PFAM TrkA-N domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_426242_1	1454004.AW11_00033	5.92e-83	259.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2VHBA@28216|Betaproteobacteria	1224|Proteobacteria	S	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_133433_1	986075.CathTA2_2026	4.1e-67	217.0	COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,4H9RU@91061|Bacilli	91061|Bacilli	G	Phosphotransfer between the C1 and C5 carbon atoms of pentose	deoB	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
k59_902818_1	644107.SL1157_A0191	2.35e-135	399.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1N3PN@1224|Proteobacteria,2U2TJ@28211|Alphaproteobacteria,4NBKA@97050|Ruegeria	28211|Alphaproteobacteria	C	Cytochrome D1 heme domain	nirS	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_81009_1	1198232.CYCME_1289	3.52e-70	232.0	COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,1RMWB@1236|Gammaproteobacteria,461WR@72273|Thiotrichales	72273|Thiotrichales	P	Iron permease FTR1 family	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	Cytochrome_CBB3,FTR1
k59_192117_1	1312954.KI914858_gene964	4.99e-56	185.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria	201174|Actinobacteria	OT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3,Response_reg
k59_1313983_1	886293.Sinac_7397	2.84e-61	203.0	COG1861@1|root,COG1861@2|Bacteria,2J3F7@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_374587_1	743718.Isova_0598	3.32e-83	283.0	COG3391@1|root,COG4733@1|root,COG3391@2|Bacteria,COG4733@2|Bacteria,2GMKC@201174|Actinobacteria,4F390@85017|Promicromonosporaceae	201174|Actinobacteria	S	fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
k59_1599866_1	765911.Thivi_2108	1.55e-91	293.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,1X2P6@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
k59_1128823_1	290340.AAur_3614	1.13e-37	129.0	COG3628@1|root,COG3628@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K06903	-	-	-	-	ko00000	-	-	-	GPW_gp25
k59_1128823_2	1001240.GY21_14080	5.55e-56	176.0	2E7P5@1|root,3324R@2|Bacteria,2ITER@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1128823_3	1349820.M707_12980	8.52e-54	184.0	COG3501@1|root,COG3501@2|Bacteria,2HGNZ@201174|Actinobacteria,1WAA4@1268|Micrococcaceae	201174|Actinobacteria	S	Rhs element vgr protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_base_V
k59_192124_2	994479.GL877878_gene26	1.47e-36	132.0	COG1162@1|root,COG1162@2|Bacteria,2GJ37@201174|Actinobacteria,4E0H1@85010|Pseudonocardiales	201174|Actinobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
k59_258576_1	713586.KB900536_gene2056	7.27e-79	249.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WW4B@135613|Chromatiales	135613|Chromatiales	T	response regulator	glnG	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_837453_1	880072.Desac_1777	1.4e-64	218.0	COG4191@1|root,COG4191@2|Bacteria,1R9SH@1224|Proteobacteria,42QAE@68525|delta/epsilon subdivisions,2WM61@28221|Deltaproteobacteria,2MR9Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	COGs COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,dCache_1
k59_1717487_1	105559.Nwat_0786	9.91e-109	324.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,1S059@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_485014_1	1225184.ALXE01000010_gene4372	1.08e-17	77.0	2D7FD@1|root,32TNY@2|Bacteria,1NAHU@1224|Proteobacteria,1S9DD@1236|Gammaproteobacteria,3W114@53335|Pantoea	1236|Gammaproteobacteria	S	Domain of unknown function (DUF1992)	yhdN	-	-	-	-	-	-	-	-	-	-	-	DUF1992
k59_485014_2	465817.ETA_26080	5.04e-41	142.0	COG4229@1|root,COG4229@2|Bacteria,1R3V9@1224|Proteobacteria,1RP5Y@1236|Gammaproteobacteria,3X5SP@551|Erwinia	1236|Gammaproteobacteria	C	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)	mtnC	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0019509,GO:0019752,GO:0042578,GO:0043094,GO:0043102,GO:0043436,GO:0043874,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.77	ko:K09880	ko00270,ko01100,map00270,map01100	M00034	R07395	RC02779	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2,Hydrolase
k59_426257_1	335543.Sfum_3765	1.27e-98	306.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MQ9H@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	fgrM	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_902846_1	661478.OP10G_1995	1.53e-14	78.6	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_776106_2	1121918.ARWE01000001_gene3561	1.78e-152	436.0	COG0388@1|root,COG0388@2|Bacteria,1MWQG@1224|Proteobacteria,42RTY@68525|delta/epsilon subdivisions,2WNFS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.5.1	ko:K01501	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120	-	R00540,R01887,R03093,R03542,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC02811	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
k59_156297_1	1121459.AQXE01000003_gene1114	6.1e-05	47.8	COG1309@1|root,COG1309@2|Bacteria,1QD1Z@1224|Proteobacteria,436TV@68525|delta/epsilon subdivisions,2X1HG@28221|Deltaproteobacteria,2MF2Q@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1740380_1	457424.BFAG_00936	7.5e-18	86.7	COG5000@1|root,COG5000@2|Bacteria,4NEWF@976|Bacteroidetes,2FN85@200643|Bacteroidia,4ANWX@815|Bacteroidaceae	976|Bacteroidetes	T	COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_8
k59_1740380_2	1298865.H978DRAFT_0695	5.58e-08	55.1	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,4642R@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	yfhA	GO:0000156,GO:0000160,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001130,GO:0001150,GO:0001151,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0023052,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0035556,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_410301_1	1121405.dsmv_2651	1.06e-89	281.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales	68525|delta/epsilon subdivisions	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_938451_1	1049564.TevJSym_ap00690	3.62e-90	271.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,1J4TW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	GO:0000027,GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008650,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
k59_859616_2	545264.KB898747_gene419	6.45e-15	73.2	COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,1SCJD@1236|Gammaproteobacteria,1WYZ4@135613|Chromatiales	135613|Chromatiales	S	Copper chaperone PCu(A)C	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	PCuAC
k59_58116_1	367299.JOEE01000001_gene1484	5.58e-65	219.0	COG0308@1|root,COG0308@2|Bacteria,2ID1N@201174|Actinobacteria,4FIRF@85021|Intrasporangiaceae	201174|Actinobacteria	E	aminopeptidase N	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_507679_1	360911.EAT1b_2895	6.25e-27	105.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,4HBFV@91061|Bacilli,3WED3@539002|Bacillales incertae sedis	91061|Bacilli	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
k59_214602_1	292415.Tbd_0772	2.32e-73	238.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2VH2W@28216|Betaproteobacteria,1KREI@119069|Hydrogenophilales	119069|Hydrogenophilales	T	Elongation factor G C-terminus	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_684557_1	935839.JAGJ01000008_gene1703	5.8e-16	80.1	COG4987@1|root,COG4987@2|Bacteria,2H79B@201174|Actinobacteria,4F41C@85017|Promicromonosporaceae	201174|Actinobacteria	V	TIGRFAM ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC	cydC	-	-	ko:K06148,ko:K16012	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.129	-	-	ABC_membrane,ABC_tran
k59_684557_2	1123024.AUII01000046_gene3931	1.72e-16	82.0	COG3850@1|root,COG3850@2|Bacteria,2GIWI@201174|Actinobacteria,4E0TS@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HATPase_c_2,HisKA_3
k59_156317_1	523791.Kkor_0376	4.48e-74	237.0	COG0654@1|root,COG0654@2|Bacteria,1R7UC@1224|Proteobacteria,1S1B9@1236|Gammaproteobacteria,1XQV5@135619|Oceanospirillales	135619|Oceanospirillales	CH	FAD binding domain	-	-	1.14.13.9	ko:K00486	ko00380,ko01100,map00380,map01100	M00038	R01960	RC00046	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_1513211_1	765911.Thivi_4484	7.66e-28	113.0	COG1449@1|root,COG1449@2|Bacteria,1Q9WP@1224|Proteobacteria,1S0Y4@1236|Gammaproteobacteria,1WX3Z@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_1279040_2	391038.Bphy_0588	1.01e-26	114.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VH55@28216|Betaproteobacteria,1K1YA@119060|Burkholderiaceae	28216|Betaproteobacteria	E	amino acid	livK2	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_1740398_1	999550.KI421507_gene1978	3.32e-198	556.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_29,HTH_32
k59_794901_1	933262.AXAM01000023_gene657	6.73e-73	234.0	COG0836@1|root,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,42MDP@68525|delta/epsilon subdivisions,2WJEN@28221|Deltaproteobacteria,2MIA7@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase	manAC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_938477_1	526225.Gobs_3422	4.06e-181	516.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4ERPD@85013|Frankiales	201174|Actinobacteria	U	PFAM Type II secretion system protein E	flpF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
k59_1104586_1	765912.Thimo_3266	5.65e-80	252.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,1WVWN@135613|Chromatiales	135613|Chromatiales	M	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N
k59_214614_2	269796.Rru_A0068	2.89e-27	111.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,2TV6U@28211|Alphaproteobacteria,2JQ9F@204441|Rhodospirillales	204441|Rhodospirillales	I	Lysophospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
k59_938481_1	1121448.DGI_1884	3.66e-83	256.0	COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,42MJ3@68525|delta/epsilon subdivisions,2WKD5@28221|Deltaproteobacteria,2MG30@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_507706_1	323261.Noc_0949	8.24e-36	138.0	2C6CZ@1|root,32R7W@2|Bacteria,1RH5F@1224|Proteobacteria,1S87G@1236|Gammaproteobacteria,1X27D@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF2868)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2868
k59_214616_1	1068980.ARVW01000001_gene4850	4.48e-09	60.5	COG0583@1|root,COG0583@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_214616_2	1276756.AUEX01000021_gene3304	2.98e-08	55.1	COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2VJF4@28216|Betaproteobacteria,4AD0Z@80864|Comamonadaceae	28216|Betaproteobacteria	G	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site	cbbL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
k59_58169_1	2340.JV46_13820	4.58e-64	202.0	COG0607@1|root,COG0607@2|Bacteria,1REGB@1224|Proteobacteria,1S580@1236|Gammaproteobacteria,1JA45@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1149172_1	187272.Mlg_0373	1.48e-184	522.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1WW0I@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_449004_1	396588.Tgr7_2713	1.12e-57	191.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1WX43@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
k59_58179_1	1496688.ER33_14805	2.73e-108	327.0	COG5361@1|root,COG5361@2|Bacteria,1G1YW@1117|Cyanobacteria,22TKK@167375|Cyanobium	1117|Cyanobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1740417_1	1454004.AW11_02804	1.17e-57	186.0	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2VH65@28216|Betaproteobacteria,1KPZS@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
k59_214622_1	765913.ThidrDRAFT_1746	2.63e-33	117.0	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,1WZA0@135613|Chromatiales	135613|Chromatiales	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
k59_1563723_2	396588.Tgr7_2065	7.7e-50	169.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1WX0P@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_1350204_2	1283300.ATXB01000002_gene2873	4.18e-32	116.0	COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,1S3XB@1236|Gammaproteobacteria,1XGDH@135618|Methylococcales	135618|Methylococcales	F	Nudix N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N_2
k59_1104600_1	1249627.D779_2918	1.65e-57	188.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1WXJR@135613|Chromatiales	135613|Chromatiales	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_997766_1	305700.B447_07137	2.49e-102	313.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2VJEQ@28216|Betaproteobacteria,2KUQ3@206389|Rhodocyclales	206389|Rhodocyclales	G	BT1 family	-	-	-	-	-	-	-	-	-	-	-	-	BT1
k59_290829_1	1048339.KB913029_gene1988	2.25e-31	125.0	arCOG02771@1|root,2Z8A4@2|Bacteria,2GNG0@201174|Actinobacteria,4EUX7@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_743284_1	1304885.AUEY01000006_gene712	1.03e-09	65.1	COG3419@1|root,COG4964@1|root,COG3419@2|Bacteria,COG4964@2|Bacteria,1NUAV@1224|Proteobacteria,42NJ7@68525|delta/epsilon subdivisions,2WKJV@28221|Deltaproteobacteria,2MHMF@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Tfp pilus assembly protein tip-associated adhesin	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC,PA14
k59_1149196_1	398767.Glov_0622	1.86e-14	72.4	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,42QWG@68525|delta/epsilon subdivisions,2WMS0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_1149196_2	525903.Taci_0092	1.19e-74	231.0	COG1117@1|root,COG1117@2|Bacteria,3TA2P@508458|Synergistetes	508458|Synergistetes	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_567396_1	439235.Dalk_5241	3.49e-49	159.0	COG3436@1|root,COG3436@2|Bacteria,1MZFT@1224|Proteobacteria,42URZ@68525|delta/epsilon subdivisions,2WQ58@28221|Deltaproteobacteria,2MKGK@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k59_450166_1	1255043.TVNIR_0849	3.61e-79	248.0	COG5557@1|root,COG5557@2|Bacteria,1MXP7@1224|Proteobacteria,1RS7Z@1236|Gammaproteobacteria,1WX2A@135613|Chromatiales	135613|Chromatiales	C	PFAM Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_292632_1	1306174.JODP01000016_gene7187	1.28e-35	125.0	COG0184@1|root,COG0184@2|Bacteria,2IQA0@201174|Actinobacteria	201174|Actinobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
k59_1280371_1	1122194.AUHU01000003_gene2111	1.76e-09	65.5	COG0457@1|root,COG0457@2|Bacteria,1MVCA@1224|Proteobacteria,1RQQS@1236|Gammaproteobacteria,46833@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_7,TPR_8
k59_1032932_1	471853.Bcav_2057	5.11e-58	191.0	COG2378@1|root,COG2378@2|Bacteria,2GM46@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	pafB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K13572,ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
k59_1106003_1	768671.ThimaDRAFT_2431	7.51e-133	392.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria,1WXHA@135613|Chromatiales	135613|Chromatiales	S	Peptidogalycan biosysnthesis/recognition	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
k59_567416_1	765911.Thivi_3579	4.64e-91	280.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1WVY5@135613|Chromatiales	135613|Chromatiales	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_860810_1	768671.ThimaDRAFT_2072	8.65e-87	278.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RX01@1236|Gammaproteobacteria,1X08Y@135613|Chromatiales	135613|Chromatiales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_292665_1	1440774.Y900_025280	1.71e-92	293.0	COG3957@1|root,COG3957@2|Bacteria,2GN27@201174|Actinobacteria,23506@1762|Mycobacteriaceae	201174|Actinobacteria	G	Phosphoketolase	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
k59_567417_1	590998.Celf_2311	2.73e-119	363.0	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria	201174|Actinobacteria	G	alpha amylase, catalytic	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_567418_1	653733.Selin_0554	8.08e-10	64.7	COG0621@1|root,COG0621@2|Bacteria	2|Bacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_1514605_1	644076.SCH4B_1204	1.12e-21	95.9	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2TRJJ@28211|Alphaproteobacteria,4NBDV@97050|Ruegeria	28211|Alphaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	frcC	-	-	ko:K10553	ko02010,map02010	M00218	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.7	-	-	BPD_transp_2
k59_1797337_1	880072.Desac_0832	6.79e-44	147.0	COG4656@1|root,COG4656@2|Bacteria,1MWAX@1224|Proteobacteria,42NJM@68525|delta/epsilon subdivisions,2WJJB@28221|Deltaproteobacteria,2MRCN@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Methylene-tetrahydrofolate reductase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR_C
k59_1797337_2	880072.Desac_0831	1.68e-73	228.0	COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,42NTS@68525|delta/epsilon subdivisions,2WK04@28221|Deltaproteobacteria,2MRE6@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Methylenetetrahydrofolate reductase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,MTHFR
k59_292686_1	316056.RPC_3225	3.69e-42	142.0	COG1433@1|root,COG1433@2|Bacteria,1N7S0@1224|Proteobacteria,2UBM5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM Dinitrogenase iron-molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
k59_292686_2	1249627.D779_2909	4.64e-31	117.0	COG1242@1|root,COG1242@2|Bacteria,1MUYF@1224|Proteobacteria,1RP94@1236|Gammaproteobacteria,1WWKB@135613|Chromatiales	135613|Chromatiales	S	PFAM Radical SAM	-	-	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
k59_1389021_1	1122951.ATUE01000007_gene769	5.12e-66	210.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,3NJHP@468|Moraxellaceae	1236|Gammaproteobacteria	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009898,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0019843,GO:0019897,GO:0019898,GO:0022613,GO:0031234,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0036211,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044877,GO:0046777,GO:0070181,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1901564	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
k59_744372_1	580332.Slit_1670	2.2e-47	162.0	COG3439@1|root,COG3439@2|Bacteria,1MXYT@1224|Proteobacteria,2W0RY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1797347_1	1121878.AUGL01000011_gene862	1.84e-50	172.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RR6K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	heptosyltransferase	opsX	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K12982	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_215691_1	631454.N177_0500	3.32e-61	199.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2V8Q4@28211|Alphaproteobacteria,1JQCU@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_795833_1	187272.Mlg_2442	4.25e-112	346.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales	135613|Chromatiales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1741728_1	765910.MARPU_00845	1.32e-08	53.9	COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,1S21E@1236|Gammaproteobacteria,1WXCN@135613|Chromatiales	135613|Chromatiales	H	May be involved in the biosynthesis of molybdopterin	-	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
k59_1741728_2	62928.azo1562	5.46e-43	154.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VIFK@28216|Betaproteobacteria,2KVAD@206389|Rhodocyclales	206389|Rhodocyclales	H	Molybdenum cofactor synthesis	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_685671_1	446469.Sked_27640	2.64e-76	260.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GM2E@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD2	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_450224_1	1121923.GPUN_1571	6.14e-17	85.9	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,464D7@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019904,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_292719_1	1071679.BG57_05725	7.7e-32	130.0	COG0586@1|root,COG0671@1|root,COG0586@2|Bacteria,COG0671@2|Bacteria,1R0F3@1224|Proteobacteria,2VTF9@28216|Betaproteobacteria,1K0XB@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Phosphoesterase PA-phosphatase related	yabI_1	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	LssY_C,PAP2,SNARE_assoc
k59_626194_1	756272.Plabr_3573	2.38e-24	100.0	COG3247@1|root,COG3247@2|Bacteria,2J0J3@203682|Planctomycetes	203682|Planctomycetes	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
k59_450228_1	335543.Sfum_2466	4.84e-95	300.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MR9S@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	CoA binding domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_1514650_2	1196029.ALIM01000023_gene729	9.54e-06	52.0	COG1670@1|root,COG1670@2|Bacteria,1V49W@1239|Firmicutes,4HHAP@91061|Bacilli,1ZGG6@1386|Bacillus	91061|Bacilli	J	Alanine acetyltransferase	yjcK	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
k59_1280467_1	479431.Namu_4226	9.14e-05	50.8	COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,2HF5G@201174|Actinobacteria,4ETGB@85013|Frankiales	201174|Actinobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
k59_860869_1	203122.Sde_0018	3.43e-74	238.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,464GU@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG0569 K transport systems, NAD-binding component	trkA	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0015075,GO:0015672,GO:0016020,GO:0022857,GO:0030001,GO:0034220,GO:0051179,GO:0051234,GO:0055085,GO:0098655	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	iE2348C_1286.E2348C_3552	TrkA_C,TrkA_N
k59_685692_1	521674.Plim_2294	5.36e-40	150.0	COG0841@1|root,COG0841@2|Bacteria,2IXQG@203682|Planctomycetes	203682|Planctomycetes	V	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_685692_2	743720.Psefu_2344	0.000103	44.3	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RMI7@1236|Gammaproteobacteria,1YX4M@136845|Pseudomonas putida group	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	mexE	-	-	ko:K18298	-	M00641	-	-	ko00000,ko00002,ko01504,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1389069_1	670307.HYPDE_32673	1.51e-135	403.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2TQVI@28211|Alphaproteobacteria,3N6DV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1623036_1	876044.IMCC3088_2538	4.42e-23	100.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RYI9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1461199_1	379066.GAU_2380	8.24e-103	317.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1ZSZ7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	CE	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3
k59_1226311_1	319003.Bra1253DRAFT_07063	5.25e-34	130.0	COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,2TRUQ@28211|Alphaproteobacteria,3JS93@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_1047279_1	1123257.AUFV01000009_gene2232	5.06e-17	79.3	COG1999@1|root,COG1999@2|Bacteria,1N6R6@1224|Proteobacteria,1SC88@1236|Gammaproteobacteria,1X800@135614|Xanthomonadales	135614|Xanthomonadales	S	signal sequence binding	-	-	-	-	-	-	-	-	-	-	-	-	SCO1-SenC
k59_1047279_2	1289387.AUKW01000005_gene2009	2.91e-18	89.4	COG3346@1|root,COG3346@2|Bacteria,2GR90@201174|Actinobacteria	201174|Actinobacteria	S	SURF1-like protein	-	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	SURF1
k59_1047279_3	1116472.MGMO_6c00040	2.6e-05	45.4	2EGIJ@1|root,33AAQ@2|Bacteria,1NH9B@1224|Proteobacteria,1SGKJ@1236|Gammaproteobacteria,1XFSX@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2909)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2909
k59_1047279_4	1121352.JHZP01000001_gene420	1.32e-14	71.2	COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,2VRM9@28216|Betaproteobacteria,2KQWS@206351|Neisseriales	206351|Neisseriales	F	Psort location Cytoplasmic, score 9.97	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_227618_2	247633.GP2143_07544	2.24e-41	144.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,1RRFJ@1236|Gammaproteobacteria,1J5R7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	iECO111_1330.ECO111_2936,iYL1228.KPN_02080	CcmB
k59_1752746_1	713586.KB900536_gene70	6.69e-56	187.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,1WWEG@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_227619_1	1121396.KB892900_gene2146	4.81e-89	273.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42NH6@68525|delta/epsilon subdivisions,2WJCV@28221|Deltaproteobacteria,2MHTU@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	dapL	GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1047310_1	1122134.KB893651_gene1906	6.88e-27	103.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,1S3WS@1236|Gammaproteobacteria,1XJRY@135619|Oceanospirillales	135619|Oceanospirillales	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
k59_1047310_2	187272.Mlg_0587	3.26e-25	105.0	COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1WW1X@135613|Chromatiales	135613|Chromatiales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
k59_1160590_1	396588.Tgr7_0817	1.42e-101	319.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales	135613|Chromatiales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_756637_1	545276.KB898735_gene1299	3.53e-78	239.0	COG2813@1|root,COG2813@2|Bacteria,1NEMR@1224|Proteobacteria,1RMXE@1236|Gammaproteobacteria,1WW4H@135613|Chromatiales	135613|Chromatiales	J	PFAM methyltransferase small	-	-	-	-	-	-	-	-	-	-	-	-	MTS,MTS_N
k59_1635891_1	857087.Metme_2051	1.05e-66	230.0	COG0785@1|root,COG3209@1|root,COG0785@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	mauF	-	2.7.11.1	ko:K03466,ko:K06196,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001,ko02000,ko03036	3.A.12,5.A.1.2	-	-	AAA_16,Trans_reg_C
k59_874519_1	1049564.TevJSym_bh00100	8.84e-37	135.0	COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1J59K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	TPR_1,TPR_16,TPR_2,VWA_2
k59_874519_2	765913.ThidrDRAFT_0481	6.99e-89	272.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,1WVYS@135613|Chromatiales	135613|Chromatiales	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
k59_1047327_1	247634.GPB2148_752	9.64e-49	171.0	COG0526@1|root,COG0526@2|Bacteria,1MWU8@1224|Proteobacteria,1SFUW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Protein of unknown function, DUF255	-	-	5.3.4.1	ko:K01829	-	-	-	-	ko00000,ko01000	-	-	-	Thioredoxin_7
k59_578001_1	765913.ThidrDRAFT_0705	3.61e-15	73.9	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1WX6I@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_578001_2	765911.Thivi_2154	3.98e-31	114.0	2D186@1|root,32TA3@2|Bacteria,1N5ZE@1224|Proteobacteria,1S92Y@1236|Gammaproteobacteria,1WYYH@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_756653_1	1198232.CYCME_0659	6.67e-06	48.5	COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,1RP5U@1236|Gammaproteobacteria,46010@72273|Thiotrichales	72273|Thiotrichales	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_756653_2	1123401.JHYQ01000009_gene2276	1.55e-29	114.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,462CR@72273|Thiotrichales	72273|Thiotrichales	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_169653_2	1123368.AUIS01000019_gene1219	1.06e-149	454.0	COG3290@1|root,COG5001@1|root,COG3290@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2NDJD@225057|Acidithiobacillales	225057|Acidithiobacillales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CZB,EAL,GGDEF,PAS,PAS_4
k59_518426_1	118005.AWNK01000003_gene2209	2.65e-35	138.0	COG0513@1|root,COG0513@2|Bacteria	2|Bacteria	L	helicase activity	rhlB	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0019904,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0090304,GO:0097718,GO:0140098,GO:1901360,GO:1901361,GO:1901575	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_227648_1	1232683.ADIMK_3344	2.31e-92	280.0	COG2114@1|root,COG2114@2|Bacteria,1QWNC@1224|Proteobacteria,1S3UK@1236|Gammaproteobacteria,468QZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1,4.6.1.2	ko:K01768,ko:K01769	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
k59_1401262_1	396588.Tgr7_1166	1.36e-87	273.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1WW2V@135613|Chromatiales	135613|Chromatiales	M	zinc metalloprotease	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_1401262_2	1122139.KB907865_gene1428	6.06e-74	234.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,1XIA5@135619|Oceanospirillales	135619|Oceanospirillales	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_518430_1	631362.Thi970DRAFT_03602	7.23e-134	390.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1WW6R@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_637028_1	1298865.H978DRAFT_2087	4.03e-39	149.0	COG2304@1|root,COG3419@1|root,COG2304@2|Bacteria,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,46578@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	Tfp pilus assembly protein tip-associated adhesin	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC,VWA_2
k59_1226392_1	404589.Anae109_0587	3.88e-16	78.2	COG3439@1|root,COG3439@2|Bacteria,1MXYT@1224|Proteobacteria,42VE6@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1696700_1	511062.GU3_08325	2.5e-25	105.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,1Y3MQ@135624|Aeromonadales	135624|Aeromonadales	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
k59_460844_1	1384054.N790_14535	8.72e-30	115.0	COG0258@1|root,COG0258@2|Bacteria,1RAAR@1224|Proteobacteria,1RN1S@1236|Gammaproteobacteria,1X448@135614|Xanthomonadales	135614|Xanthomonadales	L	Exodeoxyribonuclease IX	exo	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
k59_1160642_1	1000565.METUNv1_03496	1.33e-25	104.0	COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2VHIK@28216|Betaproteobacteria,2KW06@206389|Rhodocyclales	206389|Rhodocyclales	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
k59_1160642_2	1121106.JQKB01000015_gene5846	2.9e-251	711.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,2JPB3@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_578057_2	768671.ThimaDRAFT_3684	9.65e-40	140.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,1RPJM@1236|Gammaproteobacteria,1WYYP@135613|Chromatiales	135613|Chromatiales	L	DNA replication protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_1577951_1	388401.RB2150_11636	5.81e-14	69.7	COG5646@1|root,COG5646@2|Bacteria	2|Bacteria	S	Domain of unknown function (DU1801)	XK27_02315	-	-	-	-	-	-	-	-	-	-	-	DUF1801
k59_169737_1	118005.AWNK01000003_gene2219	2.95e-35	134.0	COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria	2|Bacteria	I	CoA-substrate-specific enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
k59_1160672_1	1286093.C266_05449	2.41e-45	164.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,2VJWM@28216|Betaproteobacteria,1K0ZD@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Na Pi-cotransporter II-related protein	nptA	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
k59_169753_1	880073.Calab_0711	4.62e-66	223.0	COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria	2|Bacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1696773_1	399739.Pmen_3607	4.88e-39	134.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria,1YG3C@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
k59_518482_1	1492922.GY26_06000	7.11e-40	150.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1J57P@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the peptidase S41A family	prc	GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	BAGE,DUF3340,PDZ,Peptidase_S41
k59_578095_1	1353531.AZNX01000005_gene3352	4.01e-44	165.0	COG0419@1|root,COG0419@2|Bacteria,1PV4Z@1224|Proteobacteria,2VD68@28211|Alphaproteobacteria,4BJ1W@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	ATPase involved in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_227746_1	1163407.UU7_09060	6.24e-89	280.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria,1X3QV@135614|Xanthomonadales	135614|Xanthomonadales	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.5.8.1,1.5.8.2	ko:K00317	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R01588,R02511	RC00185,RC00556,RC00557,RC00732	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
k59_345188_2	471853.Bcav_2282	1.09e-39	137.0	COG0219@1|root,COG0219@2|Bacteria,2IHN9@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	spoU	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
k59_460920_1	1051501.AYTL01000030_gene3158	0.000393	40.4	2BTFW@1|root,32NN5@2|Bacteria,1UB53@1239|Firmicutes,4IMHN@91061|Bacilli,1ZK6C@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1461353_1	1049564.TevJSym_au00070	3.28e-35	130.0	COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,1S133@1236|Gammaproteobacteria,1JAAK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
k59_460926_1	926550.CLDAP_37540	3.47e-25	103.0	COG1176@1|root,COG1176@2|Bacteria,2G6E0@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
k59_345206_1	644282.Deba_0864	8.9e-66	215.0	COG1215@1|root,COG1215@2|Bacteria,1MWH9@1224|Proteobacteria,42PX0@68525|delta/epsilon subdivisions,2WJUG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	-
k59_1807454_1	765913.ThidrDRAFT_2000	3.74e-91	280.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,1RQ65@1236|Gammaproteobacteria,1WWT1@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM FeS assembly protein SufB	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_169791_1	1232683.ADIMK_3168	2.92e-67	222.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,4647F@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Molecular chaperone. Has ATPase activity	htpG	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006974,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
k59_1461362_1	402777.KB235903_gene660	3.46e-84	268.0	COG2192@1|root,COG2192@2|Bacteria,1G1FV@1117|Cyanobacteria,1H9E9@1150|Oscillatoriales	1117|Cyanobacteria	O	carbamoyl transferase, NodU family	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
k59_1578020_2	1123487.KB892835_gene3290	2.27e-09	60.1	COG1309@1|root,COG1309@2|Bacteria,1MVQV@1224|Proteobacteria,2VK6A@28216|Betaproteobacteria,2KW36@206389|Rhodocyclales	206389|Rhodocyclales	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
k59_1752897_1	880072.Desac_1854	5.47e-105	314.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria	2|Bacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	-	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_1047519_1	1336235.JAEG01000001_gene1984	7.19e-35	121.0	2CDZD@1|root,32RYT@2|Bacteria,1N0AT@1224|Proteobacteria,2UBTM@28211|Alphaproteobacteria,4BFBE@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Virulence factor	-	-	-	-	-	-	-	-	-	-	-	-	Virulence_fact
k59_1047519_2	28258.KP05_13815	2.24e-15	77.8	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,1RMXS@1236|Gammaproteobacteria,1XIHQ@135619|Oceanospirillales	135619|Oceanospirillales	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
k59_1807470_1	391165.GbCGDNIH1_0795	8.84e-30	120.0	COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2TT9U@28211|Alphaproteobacteria,2JSE3@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_874723_1	1049564.TevJSym_ad00310	1.41e-81	255.0	2E6HP@1|root,3314Y@2|Bacteria,1QGPJ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1226556_1	768671.ThimaDRAFT_0670	7.6e-97	296.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,1RPYD@1236|Gammaproteobacteria,1WXKJ@135613|Chromatiales	135613|Chromatiales	S	Bacterial protein of unknown function (DUF853)	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
k59_169822_1	6211.A0A068Y3R8	2.31e-05	48.1	2DZJG@1|root,2S72Z@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_518520_1	247634.GPB2148_2650	6.43e-84	261.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	Glyco_hydro_17,MFS_2
k59_874732_1	1283300.ATXB01000001_gene1158	4.89e-197	588.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1XE0B@135618|Methylococcales	135618|Methylococcales	H	Vitamin B12 dependent methionine synthase, activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_1580139_1	1095767.CAHD01000014_gene930	1.94e-75	235.0	COG0839@1|root,COG0839@2|Bacteria,2GKRS@201174|Actinobacteria,4F0SA@85016|Cellulomonadaceae	201174|Actinobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_346896_1	1123073.KB899241_gene2537	4.79e-72	230.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,1X3GG@135614|Xanthomonadales	135614|Xanthomonadales	S	hydrolase of the alpha beta-hydrolase fold	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
k59_346896_2	582402.Hbal_2820	1.48e-20	99.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2TRD7@28211|Alphaproteobacteria,43X0T@69657|Hyphomonadaceae	28211|Alphaproteobacteria	H	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_1049890_1	367299.JOEE01000004_gene949	6.83e-70	215.0	COG2259@1|root,COG2259@2|Bacteria,2HD6Y@201174|Actinobacteria,4FGKG@85021|Intrasporangiaceae	201174|Actinobacteria	S	DoxX family	doxX	-	-	-	-	-	-	-	-	-	-	-	DoxX
k59_1049890_2	313589.JNB_07239	1.42e-15	74.3	COG2135@1|root,COG2135@2|Bacteria,2GKY8@201174|Actinobacteria,4FF9J@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
k59_876807_1	767434.Fraau_1806	7.4e-34	127.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1X46A@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
k59_1754443_1	272123.Anacy_4176	3.75e-27	115.0	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG2203@1|root,COG2905@1|root,COG3437@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2905@2|Bacteria,COG3437@2|Bacteria,1G09B@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k59_638660_1	196162.Noca_3273	7.31e-40	151.0	COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,4DN2T@85009|Propionibacteriales	201174|Actinobacteria	D	Required for chromosome condensation and partitioning	smc	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_1809216_1	1449049.JONW01000001_gene3349	1.77e-46	169.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2KFQR@204458|Caulobacterales	204458|Caulobacterales	EQ	Hydantoinase/oxoprolinase N-terminal region	-	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_806724_1	2074.JNYD01000003_gene3966	6.12e-89	275.0	COG1139@1|root,COG1139@2|Bacteria,2GJDR@201174|Actinobacteria,4DZA8@85010|Pseudonocardiales	201174|Actinobacteria	C	(4Fe-4S) cluster-containing protein	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
k59_1580172_1	1397528.Q671_06110	1.64e-34	125.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1RQ2D@1236|Gammaproteobacteria,1XI03@135619|Oceanospirillales	135619|Oceanospirillales	I	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_1580172_2	991905.SL003B_2822	1.22e-25	99.4	COG3439@1|root,COG3439@2|Bacteria,1RHPD@1224|Proteobacteria,2U95F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_806726_1	1304885.AUEY01000011_gene1743	2.27e-56	197.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria,2MI4X@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM formate C-acetyltransferase glycine radical	-	-	4.3.99.4	ko:K20038	-	-	-	-	ko00000,ko01000	-	-	-	Gly_radical,PFL-like
k59_1580174_1	98439.AJLL01000016_gene1690	6.84e-54	179.0	COG3383@1|root,COG3383@2|Bacteria,1G3GD@1117|Cyanobacteria	1117|Cyanobacteria	C	NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G)	hoxU	-	1.6.5.3	ko:K05588	ko00190,ko01100,map00190,map01100	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_10,Fer4_6,Fer4_9,NADH-G_4Fe-4S_3
k59_298312_1	519989.ECTPHS_13492	2.46e-108	315.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1WWXG@135613|Chromatiales	135613|Chromatiales	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
k59_709054_1	1121405.dsmv_3387	2.52e-41	142.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,42RGU@68525|delta/epsilon subdivisions,2WPHH@28221|Deltaproteobacteria,2MJYY@213118|Desulfobacterales	28221|Deltaproteobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
k59_709054_2	338963.Pcar_2003	9.35e-08	53.9	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,42RVM@68525|delta/epsilon subdivisions,2WQIY@28221|Deltaproteobacteria,43SIT@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ribosomal L25p family	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_591773_1	1048339.KB913029_gene2732	3.88e-47	157.0	COG0244@1|root,COG0244@2|Bacteria,2GM0V@201174|Actinobacteria,4ESM1@85013|Frankiales	201174|Actinobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_533015_1	795359.TOPB45_1242	5.33e-22	96.3	COG0589@1|root,COG0589@2|Bacteria,2GHQN@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	PFAM UspA	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1589252_1	593907.Celgi_3068	3.75e-73	229.0	COG1305@1|root,COG1305@2|Bacteria,2HDEK@201174|Actinobacteria	201174|Actinobacteria	E	PFAM transglutaminase domain protein	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_946424_1	882082.SaccyDRAFT_2042	6.72e-50	178.0	COG1960@1|root,COG1960@2|Bacteria,2HEKC@201174|Actinobacteria,4DZQY@85010|Pseudonocardiales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_359224_1	700598.Niako_1260	8.13e-15	74.3	COG0493@1|root,COG0493@2|Bacteria,4NM18@976|Bacteroidetes,1INYM@117747|Sphingobacteriia	976|Bacteroidetes	C	COGs COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Pyr_redox_2
k59_359224_2	697282.Mettu_3282	1.8e-90	278.0	COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,1RQHX@1236|Gammaproteobacteria,1XEVC@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4478)	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DUF3412,DUF4478,Lysine_decarbox
k59_1826751_1	1121035.AUCH01000004_gene282	3.71e-23	97.8	2AQI0@1|root,31FQP@2|Bacteria,1RI31@1224|Proteobacteria,2VUDX@28216|Betaproteobacteria,2KYD2@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1826751_2	631362.Thi970DRAFT_00019	2.01e-41	140.0	2E0WU@1|root,32WDV@2|Bacteria,1N1G5@1224|Proteobacteria,1S9KI@1236|Gammaproteobacteria,1X104@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_65761_1	631454.N177_1867	9.56e-25	109.0	COG3920@1|root,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2U6IX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HWE_HK,PAS_3,PAS_4
k59_240229_2	446471.Xcel_3368	4.96e-35	128.0	COG0492@1|root,COG0492@2|Bacteria,2GKD2@201174|Actinobacteria,4F3YH@85017|Promicromonosporaceae	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_591788_1	521719.ATXQ01000002_gene2599	2.05e-96	293.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1YDWZ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabB	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iAF1260.b2323,iAPECO1_1312.APECO1_4241,iB21_1397.B21_02208,iBWG_1329.BWG_2097,iE2348C_1286.E2348C_2463,iEC042_1314.EC042_2564,iEC55989_1330.EC55989_2567,iECABU_c1320.ECABU_c26560,iECBD_1354.ECBD_1336,iECB_1328.ECB_02248,iECDH10B_1368.ECDH10B_2485,iECDH1ME8569_1439.ECDH1ME8569_2261,iECD_1391.ECD_02248,iECED1_1282.ECED1_2787,iECIAI1_1343.ECIAI1_2400,iECIAI39_1322.ECIAI39_2472,iECNA114_1301.ECNA114_2414,iECO103_1326.ECO103_2787,iECO111_1330.ECO111_3071,iECO26_1355.ECO26_3311,iECOK1_1307.ECOK1_2605,iECP_1309.ECP_2362,iECS88_1305.ECS88_2471,iECSE_1348.ECSE_2632,iECSF_1327.ECSF_2200,iECUMN_1333.ECUMN_2663,iECW_1372.ECW_m2512,iEKO11_1354.EKO11_1442,iETEC_1333.ETEC_2459,iEcDH1_1363.EcDH1_1333,iEcHS_1320.EcHS_A2474,iEcSMS35_1347.EcSMS35_2480,iEcolC_1368.EcolC_1329,iJN746.PP_4175,iJO1366.b2323,iJR904.b2323,iLF82_1304.LF82_0605,iNRG857_1313.NRG857_11765,iSBO_1134.SBO_2360,iUMN146_1321.UM146_05195,iUTI89_1310.UTI89_C2608,iWFL_1372.ECW_m2512,iY75_1357.Y75_RS12180,ic_1306.c2869	Ketoacyl-synt_C,ketoacyl-synt
k59_1061783_1	243233.MCA0719	1.22e-34	122.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,1XF5B@135618|Methylococcales	135618|Methylococcales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
k59_592448_2	177437.HRM2_31410	1.44e-16	73.2	COG3242@1|root,COG3242@2|Bacteria,1N7I0@1224|Proteobacteria,4368U@68525|delta/epsilon subdivisions,2X0TC@28221|Deltaproteobacteria,2MKUY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2065)	-	-	-	ko:K09937	-	-	-	-	ko00000	-	-	-	DUF2065
k59_592448_3	1121430.JMLG01000017_gene284	1.44e-07	53.5	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia,260V0@186807|Peptococcaceae	186801|Clostridia	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
k59_66714_1	2340.JV46_25670	7.65e-51	174.0	COG0665@1|root,COG0665@2|Bacteria,1N1TN@1224|Proteobacteria,1RPIZ@1236|Gammaproteobacteria,1J5RW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	COG0665 Glycine D-amino acid oxidases (deaminating)	thiO	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
k59_416049_1	1395571.TMS3_0123410	4.33e-49	169.0	COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	dna polymerase III delta subunit	holA	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delt_C,DNA_pol3_delta
k59_474965_1	56780.SYN_00994	1.75e-106	326.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,42MTY@68525|delta/epsilon subdivisions,2WKII@28221|Deltaproteobacteria,2MQ9N@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	TIGRFAM Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_1434	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_709783_2	1453501.JELR01000002_gene766	2.75e-71	222.0	COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,1T1GE@1236|Gammaproteobacteria,4670C@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Integral membrane protein TerC family	ygdQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	TerC
k59_1062511_1	768671.ThimaDRAFT_2417	7.85e-92	281.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RS8H@1236|Gammaproteobacteria,1WWVZ@135613|Chromatiales	135613|Chromatiales	C	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_947423_2	1121405.dsmv_2159	3.08e-27	103.0	COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,42V24@68525|delta/epsilon subdivisions,2WR87@28221|Deltaproteobacteria,2MKWE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
k59_416052_1	933262.AXAM01000060_gene2883	1.22e-94	294.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MIZ@68525|delta/epsilon subdivisions,2WIUX@28221|Deltaproteobacteria,2MHR5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	CHASE5,HAMP,HATPase_c,HisKA,dCache_1,dCache_2
k59_1707680_1	765912.Thimo_1476	6.46e-35	137.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMFB@1236|Gammaproteobacteria,1X2JU@135613|Chromatiales	135613|Chromatiales	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
k59_1002621_1	1384056.N787_03270	1.64e-98	322.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1X465@135614|Xanthomonadales	135614|Xanthomonadales	E	Glutamate synthase	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_888518_1	1454010.JEOE01000008_gene1851	4.5e-289	809.0	COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria	201174|Actinobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_1062516_1	292415.Tbd_2613	1.79e-37	135.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE,Usp
k59_1062516_2	765911.Thivi_0060	3.13e-23	92.8	2EGXE@1|root,329EB@2|Bacteria,1NIPX@1224|Proteobacteria,1SHV3@1236|Gammaproteobacteria,1X1VS@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_709797_1	1121405.dsmv_3691	2.76e-113	335.0	COG3547@1|root,COG3547@2|Bacteria,1NP2U@1224|Proteobacteria,43A5Q@68525|delta/epsilon subdivisions,2X2AM@28221|Deltaproteobacteria,2MPDW@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1299664_1	713586.KB900536_gene2624	1.09e-45	157.0	COG0204@1|root,COG0204@2|Bacteria,1N2DG@1224|Proteobacteria,1S7SZ@1236|Gammaproteobacteria,1WY3Q@135613|Chromatiales	135613|Chromatiales	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_1649284_1	1172188.KB911821_gene1448	4.88e-78	246.0	COG1181@1|root,COG1181@2|Bacteria,2GITC@201174|Actinobacteria,4FEUY@85021|Intrasporangiaceae	201174|Actinobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_1299666_1	1120947.ATUX01000006_gene459	1.54e-82	260.0	COG1559@1|root,COG1559@2|Bacteria,2GKGQ@201174|Actinobacteria,4D32F@85005|Actinomycetales	201174|Actinobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_651184_1	177437.HRM2_12840	1.82e-43	150.0	COG0620@1|root,COG0620@2|Bacteria,1QB3M@1224|Proteobacteria,42NP4@68525|delta/epsilon subdivisions,2WK9Z@28221|Deltaproteobacteria,2MJ74@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_651184_2	335543.Sfum_3172	4.2e-28	105.0	COG3829@1|root,COG3829@2|Bacteria,1QVJM@1224|Proteobacteria,43CC9@68525|delta/epsilon subdivisions,2X7N5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	PAS sensor protein	-	-	-	-	-	-	-	-	-	-	-	-	PAS_4
k59_888541_1	1049564.TevJSym_aa01890	3.13e-101	307.0	COG0699@1|root,COG0699@2|Bacteria,1MV59@1224|Proteobacteria,1RYGW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_1589903_2	1279017.AQYJ01000019_gene1485	6.76e-40	144.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,46552@72275|Alteromonadaceae	1236|Gammaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabB	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_66758_1	1454010.JEOE01000009_gene3153	3.48e-124	359.0	COG0745@1|root,COG0745@2|Bacteria,2GJGU@201174|Actinobacteria,4F0QH@85016|Cellulomonadaceae	201174|Actinobacteria	K	Transcriptional regulatory protein, C terminal	glnR	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
k59_66765_1	713586.KB900536_gene37	5.17e-56	197.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria	1224|Proteobacteria	L	double-strand break repair protein AddB	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
k59_651193_1	765910.MARPU_14390	5.14e-61	204.0	COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,1WXBQ@135613|Chromatiales	135613|Chromatiales	O	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_709810_1	1049564.TevJSym_bw00090	1.41e-78	253.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1J5D0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	KL	HELICc2	yoaA	GO:0003674,GO:0003824,GO:0004386,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070035,GO:0071704,GO:0090304,GO:1901360	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
k59_241554_1	314278.NB231_12696	3.92e-52	169.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1WWUP@135613|Chromatiales	135613|Chromatiales	V	PFAM N-acetylmuramoyl-L-alanine amidase family 2	-	-	3.5.1.28	ko:K03806	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	Amidase_2
k59_122754_1	2074.JNYD01000002_gene5631	6.14e-26	99.4	2C3KP@1|root,2Z802@2|Bacteria,2IFTZ@201174|Actinobacteria,4E3VK@85010|Pseudonocardiales	201174|Actinobacteria	S	phage tail protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_122754_2	1415166.NONO_c16320	1.34e-22	94.0	COG0262@1|root,COG0262@2|Bacteria,2IEXJ@201174|Actinobacteria,4FX7U@85025|Nocardiaceae	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_1299701_1	795359.TOPB45_1189	8.36e-27	107.0	2CA4A@1|root,32RQK@2|Bacteria,2GH7R@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Domain of unknown function (DUF4416)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4416
k59_1414443_1	1454010.JEOE01000008_gene1866	1.23e-81	255.0	COG1474@1|root,COG1474@2|Bacteria,2HM4W@201174|Actinobacteria	201174|Actinobacteria	LO	P-loop Domain of unknown function (DUF2791)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2791
k59_1414443_2	446471.Xcel_2916	6.94e-172	494.0	COG1373@1|root,COG1373@2|Bacteria,2GK4E@201174|Actinobacteria,4F4MP@85017|Promicromonosporaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
k59_1179377_1	396588.Tgr7_3087	1.41e-67	211.0	COG3665@1|root,COG3665@2|Bacteria,1N2KR@1224|Proteobacteria,1RN5H@1236|Gammaproteobacteria,1WY7K@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM Urea carboxylase-associated protein 2	-	-	-	ko:K09967	-	-	-	-	ko00000	-	-	-	DUF1989
k59_1179377_2	396588.Tgr7_3088	1.21e-70	218.0	COG3665@1|root,COG3665@2|Bacteria,1N9DM@1224|Proteobacteria,1RR1E@1236|Gammaproteobacteria,1WW97@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM Urea carboxylase-associated protein 1	-	-	-	ko:K09967	-	-	-	-	ko00000	-	-	-	DUF1989
k59_709822_1	999141.GME_02535	1.79e-53	177.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,1RMAX@1236|Gammaproteobacteria,1XIPA@135619|Oceanospirillales	135619|Oceanospirillales	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
k59_826974_1	1304275.C41B8_18341	1.05e-76	238.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006015,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042301,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046391,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b1207,iAPECO1_1312.APECO1_323,iB21_1397.B21_01192,iBWG_1329.BWG_1032,iE2348C_1286.E2348C_1330,iEC042_1314.EC042_1264,iEC55989_1330.EC55989_1303,iECABU_c1320.ECABU_c14780,iECBD_1354.ECBD_2414,iECB_1328.ECB_01182,iECDH10B_1368.ECDH10B_1260,iECDH1ME8569_1439.ECDH1ME8569_1146,iECD_1391.ECD_01182,iECED1_1282.ECED1_1355,iECH74115_1262.ECH74115_1688,iECIAI1_1343.ECIAI1_1228,iECIAI39_1322.ECIAI39_1543,iECNA114_1301.ECNA114_1372,iECO103_1326.ECO103_1309,iECO111_1330.ECO111_1536,iECO26_1355.ECO26_1720,iECOK1_1307.ECOK1_1360,iECP_1309.ECP_1255,iECS88_1305.ECS88_1275,iECSE_1348.ECSE_1257,iECSF_1327.ECSF_1183,iECSP_1301.ECSP_1597,iECUMN_1333.ECUMN_1504,iECW_1372.ECW_m1293,iECs_1301.ECs1712,iEKO11_1354.EKO11_2647,iETEC_1333.ETEC_1311,iEcDH1_1363.EcDH1_2440,iEcE24377_1341.EcE24377A_1355,iEcHS_1320.EcHS_A1312,iEcSMS35_1347.EcSMS35_1935,iEcolC_1368.EcolC_2419,iG2583_1286.G2583_1478,iJO1366.b1207,iJR904.b1207,iLF82_1304.LF82_1744,iNRG857_1313.NRG857_06180,iSBO_1134.SBO_1860,iSDY_1059.SDY_1256,iSSON_1240.SSON_1971,iUMN146_1321.UM146_11025,iUMNK88_1353.UMNK88_1523,iUTI89_1310.UTI89_C1401,iWFL_1372.ECW_m1293,iY75_1357.Y75_RS06300,ic_1306.c1665	Pribosyl_synth,Pribosyltran_N
k59_826974_2	675814.VIC_004797	2.12e-08	56.2	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria,1XUCF@135623|Vibrionales	135623|Vibrionales	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:1901576	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_299086_1	1267005.KB911255_gene2910	4.47e-59	190.0	COG5461@1|root,COG5461@2|Bacteria,1MWWE@1224|Proteobacteria,2TU2Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	TIGRFAM pilus (Caulobacter type) biogenesis lipoprotein CpaD	cpaD	-	-	ko:K02281	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Pilus_CpaD
k59_1002658_1	512565.AMIS_66140	1.27e-35	135.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4D8ZV@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1414454_1	367299.JOEE01000007_gene174	1.38e-45	157.0	COG2919@1|root,COG2919@2|Bacteria,2GQH7@201174|Actinobacteria,4FHRY@85021|Intrasporangiaceae	201174|Actinobacteria	D	Septation ring formation regulator EzrA	divIC	-	-	ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
k59_1299726_1	555778.Hneap_1775	8.76e-15	71.2	COG1558@1|root,COG1558@2|Bacteria,1RHI3@1224|Proteobacteria,1S653@1236|Gammaproteobacteria,1WYP3@135613|Chromatiales	135613|Chromatiales	N	Belongs to the flagella basal body rod proteins family	-	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
k59_1299726_2	1298593.TOL_2594	2.3e-39	135.0	COG1815@1|root,COG1815@2|Bacteria,1MZ8P@1224|Proteobacteria,1S9DS@1236|Gammaproteobacteria,1XK50@135619|Oceanospirillales	135619|Oceanospirillales	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	flgB	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
k59_122773_1	879212.DespoDRAFT_02587	4.72e-101	303.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ4Z@28221|Deltaproteobacteria,2MHXJ@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	PFAM type II secretion system protein E	pilT1	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_1120032_1	1280954.HPO_14526	1.66e-12	70.9	COG4961@1|root,COG4961@2|Bacteria,1N744@1224|Proteobacteria,2UGR2@28211|Alphaproteobacteria,43XVW@69657|Hyphomonadaceae	28211|Alphaproteobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
k59_7713_1	1385521.N803_01655	3.35e-92	293.0	COG1251@1|root,COG1251@2|Bacteria,2GJ3U@201174|Actinobacteria,4FF81@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	nirB	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
k59_66815_1	526225.Gobs_2302	1.05e-34	134.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4ERW2@85013|Frankiales	201174|Actinobacteria	G	SMART alpha amylase, catalytic sub domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_66815_2	1123251.ATWM01000005_gene1550	3.46e-12	65.1	COG0366@1|root,COG0366@2|Bacteria,2GJKR@201174|Actinobacteria,4FEN2@85021|Intrasporangiaceae	201174|Actinobacteria	G	Glycogen debranching enzyme, glucanotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Malt_amylase_C
k59_360287_1	349521.HCH_00764	2.11e-51	171.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,1XI57@135619|Oceanospirillales	135619|Oceanospirillales	M	mechanosensitive ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel,TM_helix
k59_1414460_1	1286631.X805_41410	3.18e-50	178.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,1KIXB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1299735_2	177439.DP1202	7.83e-66	218.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,2MHX9@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_360294_1	177437.HRM2_02370	1.26e-60	210.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MIEI@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_827010_1	765911.Thivi_3343	1.15e-69	222.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,1RMGC@1236|Gammaproteobacteria,1WWQU@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
k59_360302_1	765912.Thimo_0382	3.32e-108	328.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1WWDG@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1707752_1	1249627.D779_2799	2.31e-73	233.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1WWUV@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_7747_1	572477.Alvin_0325	4.71e-179	520.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1WVYF@135613|Chromatiales	135613|Chromatiales	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1299764_1	572477.Alvin_1505	1.61e-111	333.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1WW90@135613|Chromatiales	135613|Chromatiales	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_651255_1	335543.Sfum_1178	1.1e-55	188.0	COG1148@1|root,COG1148@2|Bacteria,1PH3R@1224|Proteobacteria,42PTD@68525|delta/epsilon subdivisions,2WIZ5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Pyr_redox_2
k59_1531464_1	933262.AXAM01000053_gene2714	7.06e-85	263.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,42M5K@68525|delta/epsilon subdivisions,2WJTS@28221|Deltaproteobacteria,2MHZ2@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2261	ATP-grasp_2,Ligase_CoA
k59_827024_2	196367.JNFG01000019_gene4435	4.67e-52	177.0	COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2VI1D@28216|Betaproteobacteria,1K0D5@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	rsmB_2	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0031974,GO:0031981,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0070013,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N
k59_1002685_2	411459.RUMOBE_00186	5.66e-45	157.0	COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,2482Z@186801|Clostridia,3XZ6D@572511|Blautia	186801|Clostridia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_651259_1	367299.JOEE01000002_gene2432	1.2e-94	283.0	COG0671@1|root,COG0671@2|Bacteria,2I9FB@201174|Actinobacteria,4FEH1@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
k59_1062612_2	1279019.ARQK01000056_gene265	2.21e-15	76.3	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,1WX2W@135613|Chromatiales	135613|Chromatiales	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
k59_658014_1	1123065.ATWL01000001_gene216	3.47e-39	140.0	COG1560@1|root,COG1560@2|Bacteria,2GM7B@201174|Actinobacteria	201174|Actinobacteria	M	Lipid A biosynthesis	htrB	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.3.1.265	ko:K22311	-	-	-	-	ko00000,ko01000	-	-	-	Lip_A_acyltrans
k59_1308758_1	1151122.AQYD01000007_gene665	1.13e-73	268.0	COG2911@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG4625@1|root,COG4932@1|root,COG5373@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,COG4625@2|Bacteria,COG4932@2|Bacteria,COG5373@2|Bacteria	2|Bacteria	KLT	membrane	-	-	-	ko:K02451,ko:K03832,ko:K13735,ko:K20276,ko:K21449	ko02024,ko05100,map02024,map05100	M00331	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	1.B.40.2,2.C.1.1,9.B.42	-	-	PATR,T2SSB
k59_188386_1	497964.CfE428DRAFT_5595	3.5e-71	241.0	COG0086@1|root,COG0086@2|Bacteria,46S79@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1008045_1	439235.Dalk_1443	2.92e-64	214.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WK44@28221|Deltaproteobacteria,2MPUA@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	MFS_1,OEP
k59_1072453_1	1006004.GBAG_2084	1.23e-17	90.9	COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RR5W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	AAA_16,GAF,HATPase_c,HisKA,MASE1,PAS_3,PAS_4,PAS_9,Pkinase
k59_1072454_1	335543.Sfum_1173	1.87e-96	310.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_6,Pyr_redox_2
k59_598540_2	1137269.AZWL01000001_gene5381	3.81e-13	70.9	COG0366@1|root,COG0366@2|Bacteria,2GKK1@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	amy	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_20
k59_369369_1	1265502.KB905930_gene1427	2.88e-112	340.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,4ABI0@80864|Comamonadaceae	28216|Betaproteobacteria	O	Heat shock 70 kDa protein	dnaK	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_1308770_1	13035.Dacsa_2625	8.44e-10	66.2	COG3210@1|root,COG3595@1|root,COG4070@1|root,COG3210@2|Bacteria,COG3595@2|Bacteria,COG4070@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	ko:K15125,ko:K20276	ko02024,ko05133,map02024,map05133	-	-	-	ko00000,ko00001,ko00536	-	-	-	CHU_C,DUF4097,FG-GAP_2,Glug,Haemagg_act,Laminin_G_3,PA14,SprB
k59_20347_1	1125712.HMPREF1316_0579	2.98e-69	221.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4CUUN@84998|Coriobacteriia	84998|Coriobacteriia	P	ABC transporter, ATP-binding protein	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_369374_2	1049564.TevJSym_ah00220	5.75e-36	124.0	COG1993@1|root,COG1993@2|Bacteria,1N8TP@1224|Proteobacteria,1SDYH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
k59_1008051_1	391615.ABSJ01000039_gene1801	1.5e-55	181.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,1J4MF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
k59_956641_1	768671.ThimaDRAFT_2578	1.46e-46	163.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1WX2U@135613|Chromatiales	135613|Chromatiales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_1596185_1	1177181.T9A_00657	1.79e-54	180.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,1XIR9@135619|Oceanospirillales	135619|Oceanospirillales	P	Sulfurtransferase	glpE	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_1247822_2	2340.JV46_04430	8.01e-110	323.0	COG1277@1|root,COG1277@2|Bacteria,1MWUZ@1224|Proteobacteria,1RQFG@1236|Gammaproteobacteria,1JBG1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	ABC-2 family transporter protein	nosY	-	-	ko:K19341	ko02010,map02010	M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.132.2	-	-	ABC2_membrane_2
k59_305236_1	1123020.AUIE01000030_gene2649	3.19e-55	192.0	COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1YCZA@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	TPR_1,TPR_2,VWA_2
k59_1125562_2	494419.ALPM01000122_gene1309	4.49e-82	259.0	COG1621@1|root,COG1621@2|Bacteria,2H3S0@201174|Actinobacteria	201174|Actinobacteria	G	Glycosyl hydrolase family 32	-	-	3.2.1.26	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R00802,R02410,R03635,R03921,R06088	RC00028,RC00077	ko00000,ko00001,ko01000	-	GH32	-	Glyco_hydro_32N
k59_1072490_1	685727.REQ_21230	5.32e-14	70.9	COG4447@1|root,COG4447@2|Bacteria,2GN53@201174|Actinobacteria,4G06I@85025|Nocardiaceae	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
k59_1361830_2	1492922.GY26_04450	2.23e-26	110.0	COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,1RMH4@1236|Gammaproteobacteria,1J60F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	COG0642 Signal transduction histidine kinase	regB	-	2.7.13.3	ko:K15011	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_75876_1	472759.Nhal_0236	4.9e-104	313.0	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,1RNMF@1236|Gammaproteobacteria,1WVZX@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
k59_422689_2	596154.Alide2_2578	5.56e-06	52.8	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VJ1B@28216|Betaproteobacteria,4AAFT@80864|Comamonadaceae	28216|Betaproteobacteria	M	RND efflux system, outer membrane lipoprotein, NodT	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_20371_1	266940.Krad_3173	6.62e-109	319.0	COG0106@1|root,COG0106@2|Bacteria,2GJ4V@201174|Actinobacteria	201174|Actinobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16,5.3.1.24	ko:K01814,ko:K01817	ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230	M00023,M00026	R03509,R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_833848_1	1049564.TevJSym_bk00240	4.53e-120	353.0	COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,1RRWT@1236|Gammaproteobacteria,1JAVX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_957705_1	314345.SPV1_11191	9.62e-47	163.0	2BH5I@1|root,32B6M@2|Bacteria,1RKHK@1224|Proteobacteria	1224|Proteobacteria	S	PFAM NERD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	NERD
k59_834570_1	351348.Maqu_0609	1.75e-115	345.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW8A@1224|Proteobacteria,1RRNV@1236|Gammaproteobacteria,46D6X@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_29,HTH_32,HTH_33
k59_1309867_1	1122185.N792_03020	2.96e-12	64.3	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,1S36X@1236|Gammaproteobacteria,1X3XG@135614|Xanthomonadales	135614|Xanthomonadales	S	FeS assembly SUF system protein SufT	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
k59_1309867_2	1207063.P24_03775	2.24e-50	165.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,2U8SC@28211|Alphaproteobacteria,2JSHE@204441|Rhodospirillales	204441|Rhodospirillales	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
k59_1309867_3	1198232.CYCME_1546	5.77e-28	110.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,45ZNF@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
k59_482215_1	796620.VIBC2010_11571	5.35e-10	58.2	COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,1S3PA@1236|Gammaproteobacteria,1XXD8@135623|Vibrionales	135623|Vibrionales	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
k59_482215_2	314278.NB231_08157	5e-94	277.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,1RMW0@1236|Gammaproteobacteria,1WWG3@135613|Chromatiales	135613|Chromatiales	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
k59_76931_1	203122.Sde_2353	3.03e-122	369.0	COG3383@1|root,COG3383@2|Bacteria,1QX06@1224|Proteobacteria	1224|Proteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1483983_1	768671.ThimaDRAFT_1735	1.88e-88	284.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1WVXM@135613|Chromatiales	135613|Chromatiales	P	heavy metal translocating P-type ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_1773006_1	396588.Tgr7_2900	5.41e-36	135.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_189175_2	425104.Ssed_3607	1.52e-46	152.0	2B6UZ@1|root,31ZUH@2|Bacteria,1QDF2@1224|Proteobacteria,1T9DM@1236|Gammaproteobacteria,2QC2Z@267890|Shewanellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1126264_2	1089552.KI911559_gene640	4.13e-173	499.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2TQJA@28211|Alphaproteobacteria,2JP96@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_658850_1	1150399.AQYK01000002_gene3678	1.22e-05	49.3	COG3187@1|root,COG3187@2|Bacteria,2GZGE@201174|Actinobacteria,4FQDT@85023|Microbacteriaceae	201174|Actinobacteria	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
k59_1422243_1	1132441.KI519454_gene1434	9.67e-74	233.0	COG1741@1|root,COG1741@2|Bacteria,2GM9P@201174|Actinobacteria,1W7QV@1268|Micrococcaceae	201174|Actinobacteria	S	Pirin	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
k59_1126268_1	768671.ThimaDRAFT_4169	3.15e-114	347.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,1WXFC@135613|Chromatiales	135613|Chromatiales	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_76949_2	1242864.D187_004215	7.55e-09	60.1	COG1716@1|root,COG2114@1|root,COG2203@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,COG2203@2|Bacteria,1RAHZ@1224|Proteobacteria,42UGY@68525|delta/epsilon subdivisions,2WQPI@28221|Deltaproteobacteria,2YUG9@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA,GAF,GAF_2,Guanylate_cyc
k59_773772_1	713586.KB900536_gene1501	7.77e-33	128.0	COG0500@1|root,COG1047@1|root,COG1047@2|Bacteria,COG2226@2|Bacteria,1PCH2@1224|Proteobacteria,1S09M@1236|Gammaproteobacteria,1X09N@135613|Chromatiales	135613|Chromatiales	OQ	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_773772_2	153948.NAL212_1251	5.83e-37	126.0	COG2119@1|root,COG2119@2|Bacteria,1NDE6@1224|Proteobacteria	1224|Proteobacteria	S	family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
k59_1657051_1	1121405.dsmv_1994	6.07e-53	169.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,42U92@68525|delta/epsilon subdivisions,2WQCK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_1657051_2	335543.Sfum_1942	2.77e-30	119.0	COG0377@1|root,COG0649@1|root,COG0852@1|root,COG0377@2|Bacteria,COG0649@2|Bacteria,COG0852@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria,2MR1T@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoBCD	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00333,ko:K13378,ko:K13380	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa,Oxidored_q6
k59_370481_1	1116375.VEJY3_13845	3.51e-39	149.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1XSQP@135623|Vibrionales	135623|Vibrionales	NU	COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	mshE	-	-	ko:K12276	ko05111,map05111	-	-	-	ko00000,ko00001,ko02044	-	-	-	T2SSE,T2SSE_N
k59_1073944_1	1236542.BALM01000001_gene214	1.3e-50	175.0	COG3104@1|root,COG3104@2|Bacteria,1P6K2@1224|Proteobacteria,1RZ5I@1236|Gammaproteobacteria,2Q8GE@267890|Shewanellaceae	1236|Gammaproteobacteria	E	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1538663_1	292415.Tbd_1116	6.38e-56	186.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VK4X@28216|Betaproteobacteria,1KT30@119069|Hydrogenophilales	119069|Hydrogenophilales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1422253_2	314278.NB231_05631	1.2e-20	85.1	COG3116@1|root,COG3116@2|Bacteria,1NI3C@1224|Proteobacteria,1SGSB@1236|Gammaproteobacteria,1WZ00@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsL	-	-	ko:K03586	-	-	-	-	ko00000,ko03036	-	-	-	FtsL
k59_1422253_3	983545.Glaag_0837	2.03e-17	82.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,464CX@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_189195_1	323261.Noc_0218	4.9e-135	401.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1WXKA@135613|Chromatiales	135613|Chromatiales	G	PFAM Alpha amylase, catalytic	-	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_599325_1	367299.JOEE01000004_gene1022	3.69e-90	289.0	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4FFTS@85021|Intrasporangiaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 65, C-terminal domain	-	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
k59_423472_1	936455.KI421499_gene3801	9.38e-84	272.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2USBQ@28211|Alphaproteobacteria,3JRFR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	ABC transporter	-	-	-	ko:K06147,ko:K11004	ko02010,ko03070,ko05133,map02010,map03070,map05133	M00325,M00575	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.106,3.A.1.109,3.A.1.109.1,3.A.1.109.2,3.A.1.21	-	-	ABC_membrane,ABC_tran,Peptidase_C39
k59_1838141_1	1255043.TVNIR_2410	3.61e-143	412.0	COG0438@1|root,COG0438@2|Bacteria,1RB3J@1224|Proteobacteria,1RW61@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0438 Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
k59_370494_1	1454010.JEOE01000032_gene2878	2.45e-66	211.0	COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4F107@85016|Cellulomonadaceae	201174|Actinobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
k59_482242_1	1288494.EBAPG3_400	1.03e-119	366.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,372JJ@32003|Nitrosomonadales	28216|Betaproteobacteria	MU	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
k59_482242_2	1452718.JBOY01000024_gene350	5.01e-31	122.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_1484024_1	349521.HCH_06117	3.52e-104	324.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1XIJU@135619|Oceanospirillales	135619|Oceanospirillales	V	(ABC) transporter	-	-	-	ko:K11004,ko:K13409	ko02010,ko03070,ko04626,ko05133,map02010,map03070,map04626,map05133	M00325,M00339,M00575	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.1,3.A.1.109.2,3.A.1.110	-	-	ABC_membrane,ABC_tran,Peptidase_C39
k59_1597038_1	1123059.KB823012_gene2113	1.52e-52	177.0	COG2021@1|root,COG2021@2|Bacteria,1PPZX@1224|Proteobacteria,2VC2N@28211|Alphaproteobacteria,43XX9@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	alpha/beta hydrolase fold	-	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_1838157_1	1307436.PBF_08358	1.21e-14	74.7	COG3279@1|root,COG3279@2|Bacteria,1V5A0@1239|Firmicutes,4HIBS@91061|Bacilli,1ZEPQ@1386|Bacillus	91061|Bacilli	T	COG3279 Response regulator of the LytR AlgR family	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
k59_1187309_1	1396141.BATP01000066_gene1894	5.18e-42	142.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_Tnp_IS630
k59_306011_1	96561.Dole_2296	1.19e-92	280.0	COG3264@1|root,COG3264@2|Bacteria,1QUBW@1224|Proteobacteria,43BRN@68525|delta/epsilon subdivisions,2X72H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel,TM_helix
k59_1362707_1	1123393.KB891316_gene1118	1.22e-59	204.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,2W1SC@28216|Betaproteobacteria,1KSI9@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Protein of unknown function, DUF255	-	-	-	-	-	-	-	-	-	-	-	-	Thioredox_DsbH
k59_76986_2	251221.35211734	2.12e-15	80.5	COG0364@1|root,COG0364@2|Bacteria,1G3RG@1117|Cyanobacteria	1117|Cyanobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_1008739_1	1049564.TevJSym_ba00100	1.65e-76	249.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1J4CD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_599336_2	1051632.TPY_2868	2.26e-30	119.0	COG1484@1|root,COG1484@2|Bacteria,1TPPI@1239|Firmicutes,24DKZ@186801|Clostridia	186801|Clostridia	L	IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_834621_1	543913.D521_1871	3.22e-36	136.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2VJPX@28216|Betaproteobacteria,1KPVE@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_834621_2	335543.Sfum_3531	9.15e-14	71.6	COG1150@1|root,COG2452@1|root,COG1150@2|Bacteria,COG2452@2|Bacteria,1QZ4H@1224|Proteobacteria,43CFH@68525|delta/epsilon subdivisions,2X7QJ@28221|Deltaproteobacteria,2MSKT@213462|Syntrophobacterales	2|Bacteria	C	TIGRFAM DNA binding domain, excisionase family	dld	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K16887,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_7,Fer4_8,HTH_17,MerR_1
k59_1309936_1	1265505.ATUG01000002_gene1022	3.08e-49	172.0	COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,1R7WZ@1224|Proteobacteria,42Q3R@68525|delta/epsilon subdivisions,2WM5A@28221|Deltaproteobacteria,2MIDF@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,SSF,SpoIIE
k59_255021_1	1234664.AMRO01000079_gene560	4.21e-16	77.0	COG0075@1|root,COG1213@1|root,COG0075@2|Bacteria,COG1213@2|Bacteria,1TPS0@1239|Firmicutes,4IETS@91061|Bacilli,1WHEJ@129337|Geobacillus	91061|Bacilli	EM	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily	phnW	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5,NTP_transf_3
k59_1074006_2	314287.GB2207_04114	0.000113	44.7	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1S6CV@1236|Gammaproteobacteria,1J9W5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_658892_1	1348657.M622_03670	7.89e-44	145.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2VSPE@28216|Betaproteobacteria,2KWM4@206389|Rhodocyclales	206389|Rhodocyclales	P	protein affecting Mg2 Co2 transport	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
k59_1249009_1	935839.JAGJ01000005_gene2599	8.76e-38	138.0	2DN6F@1|root,32VT2@2|Bacteria,2I0K5@201174|Actinobacteria,4F49U@85017|Promicromonosporaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1309940_1	768671.ThimaDRAFT_2471	1.36e-158	454.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,1RYPY@1236|Gammaproteobacteria,1X08U@135613|Chromatiales	135613|Chromatiales	S	Transposase zinc-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_1422286_1	857087.Metme_1887	1.53e-30	117.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1XGD1@135618|Methylococcales	135618|Methylococcales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_380500_1	740709.A10D4_07345	8.65e-109	318.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,1RMK9@1236|Gammaproteobacteria,2QFCE@267893|Idiomarinaceae	1236|Gammaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_1603910_1	1121405.dsmv_2113	1.59e-100	298.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,42N4U@68525|delta/epsilon subdivisions,2WJR7@28221|Deltaproteobacteria,2MHSN@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
k59_1258093_1	177437.HRM2_05930	3.06e-52	167.0	COG0426@1|root,COG0426@2|Bacteria,1N47N@1224|Proteobacteria,42UNB@68525|delta/epsilon subdivisions,2WQA6@28221|Deltaproteobacteria,2MQ13@213118|Desulfobacterales	28221|Deltaproteobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5
k59_1258093_2	439235.Dalk_3841	6.09e-29	104.0	COG1141@1|root,COG1141@2|Bacteria,1NEIN@1224|Proteobacteria,42V6F@68525|delta/epsilon subdivisions,2WR6R@28221|Deltaproteobacteria,2MKY6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S single cluster domain	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
k59_967733_1	395494.Galf_2867	1.77e-50	177.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,44VMC@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	pap	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_1429501_1	439235.Dalk_5256	2.71e-135	395.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria,2MNIW@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_430494_1	617140.AJZE01000078_gene1847	3.35e-98	306.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGA@1236|Gammaproteobacteria,1XXNF@135623|Vibrionales	135623|Vibrionales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1319989_2	288000.BBta_4639	7.91e-16	74.7	COG2197@1|root,COG2197@2|Bacteria,1R2TM@1224|Proteobacteria,2TU4S@28211|Alphaproteobacteria,3JQUU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	helix_turn_helix, Lux Regulon	MA20_20785	-	-	ko:K07684,ko:K07693	ko02020,map02020	M00471,M00479	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_1545763_1	313606.M23134_06826	6.2e-24	100.0	COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,47MV2@768503|Cytophagia	976|Bacteroidetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_724315_1	1249627.D779_3210	1.64e-181	530.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WW1G@135613|Chromatiales	135613|Chromatiales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_489326_1	579138.Zymop_1434	1.4e-11	68.2	COG3921@1|root,COG3921@2|Bacteria,1N3WR@1224|Proteobacteria,2U1ZC@28211|Alphaproteobacteria,2KD40@204457|Sphingomonadales	204457|Sphingomonadales	S	PFAM Extensin family protein	-	-	-	-	-	-	-	-	-	-	-	-	Extensin-like_C
k59_31603_1	300852.55771902	2.22e-73	237.0	COG0281@1|root,COG0281@2|Bacteria,1WIZY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	PFAM Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
k59_265411_1	1415778.JQMM01000001_gene958	2.99e-168	490.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,1J5DB@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_1429511_1	471853.Bcav_4214	2.36e-232	648.0	COG1167@1|root,COG1167@2|Bacteria,2GITW@201174|Actinobacteria	201174|Actinobacteria	EK	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs	avtA	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
k59_908803_1	335543.Sfum_2865	1.39e-24	107.0	COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,42NG6@68525|delta/epsilon subdivisions,2WIRU@28221|Deltaproteobacteria,2MQH9@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
k59_1429514_1	590998.Celf_3453	7.65e-47	166.0	COG5650@1|root,COG5650@2|Bacteria,2GN1J@201174|Actinobacteria,4F2B9@85016|Cellulomonadaceae	201174|Actinobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
k59_1780353_1	1249627.D779_3727	3.05e-97	295.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1WVUW@135613|Chromatiales	135613|Chromatiales	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_606545_1	380703.AHA_4139	2.66e-133	390.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria,1Y586@135624|Aeromonadales	135624|Aeromonadales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.113	ko:K12256	ko00330,ko01100,map00330,map01100	-	R08714	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_1084008_1	926569.ANT_12300	7.58e-56	178.0	COG3293@1|root,COG3293@2|Bacteria,2G9EK@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
k59_908815_1	396588.Tgr7_2035	6.79e-36	132.0	COG3395@1|root,COG3395@2|Bacteria,1QKU1@1224|Proteobacteria,1TIZB@1236|Gammaproteobacteria,1WXF7@135613|Chromatiales	135613|Chromatiales	S	Type III effector Hrp-dependent	-	-	-	-	-	-	-	-	-	-	-	-	DUF1357_C,DUF1537
k59_1429525_1	768671.ThimaDRAFT_2143	1.01e-58	193.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1WWA8@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_1603944_1	471853.Bcav_2908	6.19e-92	274.0	COG2095@1|root,COG2095@2|Bacteria,2GMCM@201174|Actinobacteria	201174|Actinobacteria	U	UPF0056 membrane protein	marC	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
k59_1780367_1	652103.Rpdx1_3857	2.47e-42	158.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,3JQNW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	actP	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
k59_1084016_1	472759.Nhal_0357	3.2e-116	343.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1WXUS@135613|Chromatiales	1236|Gammaproteobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_1132967_2	65093.PCC7418_2890	1.87e-16	79.0	COG4803@1|root,COG4803@2|Bacteria,1G531@1117|Cyanobacteria	1117|Cyanobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
k59_1492718_1	314345.SPV1_08456	2.11e-106	328.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria	1224|Proteobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	-	-	-	-	-	-	-	-	-	-	-	-	XFP,XFP_N
k59_1429531_1	244582.JQAK01000001_gene1813	1.56e-12	65.9	COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,2UBYU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	cytochrome b561	-	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB,YceI
k59_489357_1	521393.JH806634_gene2238	1.06e-23	97.1	COG1595@1|root,COG1595@2|Bacteria,2GJ02@201174|Actinobacteria,4D431@85005|Actinomycetales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigH	GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_665933_1	568768.CM001975_gene3210	3.29e-94	298.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPES@1236|Gammaproteobacteria,2JCXH@204037|Dickeya	1236|Gammaproteobacteria	S	PFAM ABC transporter related	yheS	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_1194509_1	1121912.AUHD01000035_gene1852	1.15e-07	49.7	2B9ZZ@1|root,323DM@2|Bacteria,4NTEB@976|Bacteroidetes,1I2YU@117743|Flavobacteriia	976|Bacteroidetes	S	COG NOG15344 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_430548_1	367299.JOEE01000004_gene976	9.83e-93	285.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4FEVS@85021|Intrasporangiaceae	201174|Actinobacteria	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1429540_1	670307.HYPDE_40913	9.96e-60	191.0	COG1051@1|root,COG1051@2|Bacteria,1QU0T@1224|Proteobacteria,2TW25@28211|Alphaproteobacteria,3N9IS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
k59_841753_1	446471.Xcel_1674	7.05e-17	79.0	COG1793@1|root,COG1793@2|Bacteria,2I2EA@201174|Actinobacteria,4F3U6@85017|Promicromonosporaceae	201174|Actinobacteria	L	ATP dependent DNA ligase domain	ligC	-	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
k59_841753_2	1449069.JMLO01000010_gene428	3.12e-102	308.0	COG0686@1|root,COG0686@2|Bacteria,2GJ6G@201174|Actinobacteria,4FURB@85025|Nocardiaceae	201174|Actinobacteria	E	Belongs to the AlaDH PNT family	ald	GO:0000286,GO:0001666,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009628,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030312,GO:0036293,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050896,GO:0055114,GO:0070482,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_1492742_2	1123399.AQVE01000010_gene3273	4.31e-09	60.5	COG0699@1|root,COG0699@2|Bacteria,1MV59@1224|Proteobacteria,1RYGW@1236|Gammaproteobacteria,46275@72273|Thiotrichales	72273|Thiotrichales	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_606579_2	1095767.CAHD01000245_gene2502	7.2e-33	129.0	2C0QS@1|root,32R7D@2|Bacteria,2I5R9@201174|Actinobacteria,4F1Y4@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_380579_1	1121895.Q765_19790	3.11e-161	457.0	COG3507@1|root,COG3507@2|Bacteria,4NFU3@976|Bacteroidetes,1HYQR@117743|Flavobacteriia,2NUNJ@237|Flavobacterium	976|Bacteroidetes	G	Glycosyl hydrolases family 43	-	-	3.2.1.99	ko:K06113	-	-	-	-	ko00000,ko01000	-	GH43	-	Glyco_hydro_43,RicinB_lectin_2
k59_1848216_1	1123258.AQXZ01000017_gene4378	6.62e-24	99.4	COG1606@1|root,COG1606@2|Bacteria,2GPA1@201174|Actinobacteria	201174|Actinobacteria	S	PFAM ExsB family protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase,QueC
k59_1848216_2	1123258.AQXZ01000017_gene4379	3.09e-13	69.7	COG1691@1|root,COG1691@2|Bacteria,2IAKU@201174|Actinobacteria	201174|Actinobacteria	C	(AIR) carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
k59_1780391_1	987059.RBXJA2T_09642	2.24e-20	91.7	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2VHJ8@28216|Betaproteobacteria,1KJT2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA	rlmD	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_1194529_1	1306174.JODP01000013_gene7858	2.69e-29	112.0	COG0324@1|root,COG0324@2|Bacteria,2GKFT@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
k59_313463_1	96561.Dole_1367	9.06e-58	201.0	COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2MHTH@213118|Desulfobacterales	28221|Deltaproteobacteria	KLT	PFAM Protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE2,Pkinase
k59_1258192_1	1049564.TevJSym_be00060	4.96e-35	125.0	COG0535@1|root,COG0535@2|Bacteria,1QUQ6@1224|Proteobacteria,1T20T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
k59_1258192_2	1255043.TVNIR_1720	8.19e-25	101.0	COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,1RZQ2@1236|Gammaproteobacteria,1WXSM@135613|Chromatiales	135613|Chromatiales	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_265507_1	1267005.KB911264_gene3155	4.37e-35	132.0	28HDQ@1|root,2Z7Q9@2|Bacteria,1R41M@1224|Proteobacteria,2TTYR@28211|Alphaproteobacteria,3N7WW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_665964_1	1249627.D779_2144	7.11e-121	353.0	COG2221@1|root,COG2221@2|Bacteria,1MVZQ@1224|Proteobacteria,1RQXZ@1236|Gammaproteobacteria,1WWM7@135613|Chromatiales	135613|Chromatiales	C	reductase, dissimilatory-type beta subunit	dsrB	-	1.8.99.5	ko:K11181	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_665964_2	2340.JV46_15520	6.52e-60	196.0	COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,1RSIM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	TIGRFAM sulfite reductase, dissimilatory-type alpha subunit	-	-	1.8.99.5	ko:K11180	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_265515_1	426114.THI_2408	1.93e-11	65.1	COG0457@1|root,COG0457@2|Bacteria,1QV5B@1224|Proteobacteria,2WGRP@28216|Betaproteobacteria,1KKRX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2,TPR_16
k59_265515_2	1328313.DS2_06236	2.57e-07	52.8	2E445@1|root,32Z0E@2|Bacteria,1N7FY@1224|Proteobacteria,1SDJE@1236|Gammaproteobacteria,468QW@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_909776_1	551275.KB899545_gene2979	6.32e-100	309.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TUIC@28211|Alphaproteobacteria,43X3B@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	ABC transporter	cmpD_1	-	-	ko:K02049,ko:K15578	ko00910,ko02010,map00910,map02010	M00188,M00438	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.16.1,3.A.1.17	-	-	ABC_tran
k59_909782_1	998674.ATTE01000001_gene1743	1.39e-17	82.4	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,45ZX2@72273|Thiotrichales	72273|Thiotrichales	P	PFAM sodium calcium exchanger	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_909782_2	765912.Thimo_2756	1.17e-41	145.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1WWFJ@135613|Chromatiales	135613|Chromatiales	M	Arabinose 5-phosphate isomerase	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
k59_1133578_1	1123368.AUIS01000007_gene2805	4e-80	254.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,2NCNV@225057|Acidithiobacillales	225057|Acidithiobacillales	F	5'-nucleotidase, C-terminal domain	-	-	-	ko:K17224	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	5_nucleotid_C
k59_968781_1	713586.KB900536_gene2343	6.65e-122	355.0	COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,1RMKF@1236|Gammaproteobacteria,1WWD5@135613|Chromatiales	135613|Chromatiales	E	Belongs to the peptidase S33 family	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
k59_1133582_1	1121926.AXWO01000003_gene901	1.42e-74	244.0	COG3408@1|root,COG3408@2|Bacteria,2GIUI@201174|Actinobacteria	201174|Actinobacteria	G	Amylo-alpha-1,6-glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
k59_431209_1	1032480.MLP_32030	1.63e-34	133.0	COG5278@1|root,COG5278@2|Bacteria,2GJ1Q@201174|Actinobacteria,4DQKD@85009|Propionibacteriales	201174|Actinobacteria	T	phosphoserine phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_909794_2	159087.Daro_1559	2.38e-25	105.0	COG2206@1|root,COG2206@2|Bacteria,1QWUX@1224|Proteobacteria,2VZ70@28216|Betaproteobacteria	28216|Betaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5,PAS_4
k59_1665158_1	1151061.CAJY01000028_gene1024	4.98e-39	139.0	COG1938@1|root,COG1938@2|Bacteria,2GK10@201174|Actinobacteria	201174|Actinobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
k59_968802_1	96561.Dole_2313	1.77e-67	221.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2MI74@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	Sigma-54 interaction domain	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	HTH_8,PAS_4,PAS_9,Sigma54_activat
k59_909811_1	439235.Dalk_0052	1.52e-67	228.0	COG0531@1|root,COG3064@1|root,COG0531@2|Bacteria,COG3064@2|Bacteria,1R4IZ@1224|Proteobacteria,42MTQ@68525|delta/epsilon subdivisions,2WK39@28221|Deltaproteobacteria,2MIIG@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,SLC12
k59_548601_1	1089455.MOPEL_080_00430	2.65e-66	227.0	COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria,2GIZP@201174|Actinobacteria,4F7M0@85018|Dermatophilaceae	201174|Actinobacteria	I	Acetyl-CoA carboxylase, central region	-	-	-	-	-	-	-	-	-	-	-	-	ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
k59_1084882_1	1279017.AQYJ01000025_gene529	8.77e-124	383.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,46425@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Efflux pump	acrB	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_381533_1	446466.Cfla_1075	4.72e-58	186.0	COG1637@1|root,COG1637@2|Bacteria,2GIYB@201174|Actinobacteria,4F0F4@85016|Cellulomonadaceae	201174|Actinobacteria	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	-	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
k59_381533_2	1032480.MLP_30120	2.72e-08	57.0	2E6YX@1|root,331I5@2|Bacteria,2IFIG@201174|Actinobacteria,4DRJC@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF2550)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2550
k59_1781018_1	1123267.JONN01000001_gene1238	1.58e-49	179.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,MRJP
k59_909830_1	765914.ThisiDRAFT_2072	1.08e-10	67.0	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1WVVA@135613|Chromatiales	135613|Chromatiales	NU	FimV C-terminal	-	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	TPR_19
k59_1015354_1	1415775.U729_724	4.99e-39	144.0	COG0044@1|root,COG0044@2|Bacteria,1TP8C@1239|Firmicutes,249W6@186801|Clostridia,36EQM@31979|Clostridiaceae	186801|Clostridia	F	PFAM amidohydrolase	hydA	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1,Urease_alpha
k59_1015354_2	1121918.ARWE01000001_gene381	5.7e-31	119.0	COG0167@1|root,COG1146@1|root,COG0167@2|Bacteria,COG1146@2|Bacteria,1MXER@1224|Proteobacteria,42YD3@68525|delta/epsilon subdivisions,2WTVV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Dihydroorotate dehydrogenase	yeiA	-	1.3.1.1	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4_21
k59_143396_1	1304865.JAGF01000001_gene2742	3.69e-82	264.0	COG3281@1|root,COG3281@2|Bacteria,2GKAP@201174|Actinobacteria,4F0MB@85016|Cellulomonadaceae	201174|Actinobacteria	G	protein, probably involved in trehalose biosynthesis	mak	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576	2.7.1.175	ko:K16146	ko00500,ko01100,map00500,map01100	-	R09945	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
k59_143396_2	1304865.JAGF01000001_gene2743	9.78e-116	352.0	COG0366@1|root,COG0366@2|Bacteria,2GIV1@201174|Actinobacteria,4F0PT@85016|Cellulomonadaceae	201174|Actinobacteria	G	SMART alpha amylase catalytic sub domain	treS	GO:0000023,GO:0000271,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016160,GO:0016161,GO:0016787,GO:0016798,GO:0016853,GO:0016866,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046872,GO:0047471,GO:0055114,GO:0071704,GO:0071944,GO:1901576	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	iNJ661.Rv0126	Alpha-amylase,Malt_amylase_C
k59_612480_2	1123257.AUFV01000001_gene1857	3.35e-40	149.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1X3C0@135614|Xanthomonadales	135614|Xanthomonadales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_5,UVR,UvrC_HhH_N
k59_1264914_1	644282.Deba_3000	2.16e-20	89.7	COG1418@1|root,COG1418@2|Bacteria,1R60M@1224|Proteobacteria,42NFJ@68525|delta/epsilon subdivisions,2WIJT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM metal-dependent phosphohydrolase HD sub	-	-	-	-	-	-	-	-	-	-	-	-	HD
k59_1264914_2	1121405.dsmv_1736	1.16e-43	151.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,42MHR@68525|delta/epsilon subdivisions,2WIY8@28221|Deltaproteobacteria,2MMXX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_847643_1	439235.Dalk_3488	2.42e-63	206.0	COG0500@1|root,COG1047@1|root,COG1047@2|Bacteria,COG2226@2|Bacteria,1PCH2@1224|Proteobacteria,42M58@68525|delta/epsilon subdivisions,2WK5Z@28221|Deltaproteobacteria,2MIYH@213118|Desulfobacterales	28221|Deltaproteobacteria	OQ	PFAM Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_391549_1	454957.IA64_03690	3.74e-20	94.0	COG1639@1|root,COG2204@1|root,COG1639@2|Bacteria,COG2204@2|Bacteria,1R6YN@1224|Proteobacteria,1S0UQ@1236|Gammaproteobacteria,1X438@135614|Xanthomonadales	135614|Xanthomonadales	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
k59_202440_1	1283300.ATXB01000001_gene1605	5.52e-139	404.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1XDU5@135618|Methylococcales	135618|Methylococcales	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	-	-	6.2.1.9	ko:K14067	ko00630,ko00680,ko01120,ko01200,map00630,map00680,map01120,map01200	M00346	R01256	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_1091360_1	998088.B565_1887	2.26e-88	279.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1Y52F@135624|Aeromonadales	135624|Aeromonadales	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_979034_1	1042375.AFPL01000004_gene646	4.68e-20	92.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,464IT@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Belongs to the PEP-utilizing enzyme family	ptsP	GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008965,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0016775,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:1901564,GO:1901698	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_143891_1	177439.DP1202	4.71e-81	258.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,2MHX9@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_1859505_1	999611.KI421504_gene494	1.02e-103	313.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,282GA@191028|Leisingera	28211|Alphaproteobacteria	L	Integrase core domain	istA	-	-	-	-	-	-	-	-	-	-	-	rve
k59_554276_1	649764.HMPREF0762_00540	7.38e-44	161.0	COG0707@1|root,COG0707@2|Bacteria,2GJEM@201174|Actinobacteria,4CUWJ@84998|Coriobacteriia	84998|Coriobacteriia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_612942_1	1101195.Meth11DRAFT_0690	5.07e-24	99.8	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,2VM32@28216|Betaproteobacteria,2KMXT@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
k59_612942_2	1209072.ALBT01000032_gene2055	4.01e-06	50.1	COG0811@1|root,COG0811@2|Bacteria,1RA2U@1224|Proteobacteria,1RPZ5@1236|Gammaproteobacteria,1FI7W@10|Cellvibrio	1236|Gammaproteobacteria	U	MotA/TolQ/ExbB proton channel family	exbB1	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_979041_1	1454004.AW11_01126	2.18e-116	346.0	COG0056@1|root,COG0056@2|Bacteria,1MVHM@1224|Proteobacteria,2VPGJ@28216|Betaproteobacteria,1KR74@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	ATP synthase alpha/beta chain, C terminal domain	atpA2	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_143896_1	1219065.VPR01S_01_03230	1.38e-71	220.0	28PFD@1|root,2ZC6I@2|Bacteria,1R8PT@1224|Proteobacteria,1S2BA@1236|Gammaproteobacteria,1XWFU@135623|Vibrionales	135623|Vibrionales	-	-	VP2004	-	-	-	-	-	-	-	-	-	-	-	-
k59_1138627_1	555779.Dthio_PD2849	3.92e-74	229.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria	1224|Proteobacteria	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_98132_1	1504981.KO116_4563	3.24e-59	197.0	COG0584@1|root,COG0584@2|Bacteria,1MVWZ@1224|Proteobacteria,1RRBP@1236|Gammaproteobacteria,1XI5G@135619|Oceanospirillales	135619|Oceanospirillales	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_436916_1	1123253.AUBD01000016_gene1969	1.42e-81	255.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,1X3WE@135614|Xanthomonadales	135614|Xanthomonadales	C	Belongs to the heme-copper respiratory oxidase family	-	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_1670881_1	335543.Sfum_1438	2.98e-38	143.0	COG0342@1|root,COG0537@1|root,COG1061@1|root,COG3886@1|root,COG0342@2|Bacteria,COG0537@2|Bacteria,COG1061@2|Bacteria,COG3886@2|Bacteria,1MV9F@1224|Proteobacteria,42NS1@68525|delta/epsilon subdivisions,2WQXY@28221|Deltaproteobacteria,2MS5Z@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HIT,Helicase_C,PLDc_2,ResIII
k59_319910_1	471853.Bcav_1010	2.44e-81	259.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1859537_1	1485544.JQKP01000011_gene716	2.71e-16	80.5	COG0845@1|root,COG0845@2|Bacteria,1QN99@1224|Proteobacteria,2VQR3@28216|Betaproteobacteria,44V5R@713636|Nitrosomonadales	28216|Betaproteobacteria	M	TIGRFAM efflux transporter, RND family, MFP subunit	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_1859537_2	396588.Tgr7_3246	5.79e-18	83.2	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1WX2G@135613|Chromatiales	135613|Chromatiales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
k59_98155_1	1049564.TevJSym_bo00170	1.08e-33	120.0	COG2010@1|root,COG2010@2|Bacteria,1N73U@1224|Proteobacteria,1SFGZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c	nirC	-	-	ko:K19344	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3
k59_98155_2	94624.Bpet4058	8.41e-07	51.2	COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,2VH1W@28216|Betaproteobacteria,3T6VP@506|Alcaligenaceae	28216|Betaproteobacteria	S	Cytochrome D1 heme domain	nirF	-	-	ko:K19345	-	-	-	-	ko00000	-	-	-	Cytochrom_D1
k59_785220_1	1454004.AW11_03580	1.61e-52	180.0	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VHA3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Phospholipase, patatin family	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_1020082_1	768671.ThimaDRAFT_2144	4.11e-172	512.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_979090_1	545264.KB898749_gene84	8.95e-39	134.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria,1WYHM@135613|Chromatiales	135613|Chromatiales	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
k59_1265539_1	395965.Msil_2109	8.29e-27	104.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,2U75W@28211|Alphaproteobacteria,3NB0E@45404|Beijerinckiaceae	28211|Alphaproteobacteria	K	ATP cone domain	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
k59_143935_1	236097.ADG881_1754	1.25e-93	279.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,1S22U@1236|Gammaproteobacteria,1XN5N@135619|Oceanospirillales	135619|Oceanospirillales	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1499985_2	765913.ThidrDRAFT_3552	1.9e-37	129.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,1S68X@1236|Gammaproteobacteria,1WXZT@135613|Chromatiales	135613|Chromatiales	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
k59_1551804_1	637911.AM305_10606	2.59e-29	116.0	COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,1RNZF@1236|Gammaproteobacteria,1Y6QC@135625|Pasteurellales	135625|Pasteurellales	S	Na -dependent transporter	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
k59_1138661_1	1265505.ATUG01000002_gene2272	1.92e-55	183.0	COG1234@1|root,COG1234@2|Bacteria,1PE64@1224|Proteobacteria,42RZR@68525|delta/epsilon subdivisions,2WMCC@28221|Deltaproteobacteria,2MIZZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_1265554_1	525897.Dbac_1083	1.93e-38	140.0	COG5361@1|root,COG5361@2|Bacteria,1NZZJ@1224|Proteobacteria,42WCT@68525|delta/epsilon subdivisions,2WRX3@28221|Deltaproteobacteria,2MEBR@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_319935_1	1480694.DC28_01020	1.3e-102	316.0	COG1217@1|root,COG1217@2|Bacteria,2J9HZ@203691|Spirochaetes	203691|Spirochaetes	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_1670910_1	78245.Xaut_3904	1.1e-26	103.0	2C07J@1|root,32SWS@2|Bacteria,1N0NW@1224|Proteobacteria,2UEKI@28211|Alphaproteobacteria,3EZVE@335928|Xanthobacteraceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1670910_2	935840.JAEQ01000005_gene1219	7.38e-24	95.9	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,43HMP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	ABC-type branched-chain amino acid transport systems ATPase component	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_41300_2	948565.AFFP02000030_gene1192	9.47e-20	80.9	COG1841@1|root,COG1841@2|Bacteria,1N6ZE@1224|Proteobacteria,1SC8N@1236|Gammaproteobacteria,1Y992@135625|Pasteurellales	135625|Pasteurellales	J	Ribosomal protein L30	rpmD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
k59_41300_3	1198232.CYCME_0762	5.98e-62	194.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,1RNEV@1236|Gammaproteobacteria,460ID@72273|Thiotrichales	72273|Thiotrichales	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_554331_2	1384054.N790_00810	8.82e-19	88.2	COG0845@1|root,COG0845@2|Bacteria,1MX0G@1224|Proteobacteria,1RN0S@1236|Gammaproteobacteria,1X433@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_1500001_1	1232410.KI421425_gene1546	2.5e-68	213.0	COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,42TN7@68525|delta/epsilon subdivisions,2WQK7@28221|Deltaproteobacteria,43TGA@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_1500001_2	1232410.KI421425_gene1545	3.71e-07	50.1	COG0848@1|root,COG0848@2|Bacteria,1N8FU@1224|Proteobacteria,42WU3@68525|delta/epsilon subdivisions,2WSMD@28221|Deltaproteobacteria,43UYT@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
k59_672226_1	1161401.ASJA01000017_gene1301	8.29e-57	183.0	COG1309@1|root,COG1309@2|Bacteria,1RE97@1224|Proteobacteria,2U8N9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	MA20_14935	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_143957_1	572477.Alvin_0720	1.46e-91	285.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1WXVV@135613|Chromatiales	135613|Chromatiales	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_1138672_1	450380.JPSY01000003_gene2791	7.9e-10	65.5	COG1835@1|root,COG1835@2|Bacteria,2GN56@201174|Actinobacteria,4FM9P@85023|Microbacteriaceae	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3,Phospholip_A2_3
k59_1331358_1	1172188.KB911823_gene364	3.95e-32	126.0	COG2244@1|root,COG2244@2|Bacteria,2GJV2@201174|Actinobacteria,4FFXP@85021|Intrasporangiaceae	201174|Actinobacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt
k59_391680_1	590998.Celf_0158	6.05e-131	393.0	COG3299@1|root,COG3299@2|Bacteria,2GM5C@201174|Actinobacteria	201174|Actinobacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
k59_319955_1	882.DVU_2302	1.2e-25	107.0	COG0490@1|root,COG1226@1|root,COG4651@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WK23@28221|Deltaproteobacteria,2M809@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
k59_1331372_1	879212.DespoDRAFT_00640	6.72e-11	60.1	2E0F6@1|root,32W1G@2|Bacteria,1N6I3@1224|Proteobacteria,42V01@68525|delta/epsilon subdivisions,2WQWS@28221|Deltaproteobacteria,2MMAB@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_730792_1	1463821.JOGR01000001_gene1432	1.95e-30	118.0	COG1190@1|root,COG1190@2|Bacteria,2GKE0@201174|Actinobacteria,4EXUX@85014|Glycomycetales	201174|Actinobacteria	J	tRNA synthetases class II (D, K and N)	lysS	GO:0008150,GO:0040007	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_730792_2	73044.JNXP01000019_gene1022	3.6e-73	224.0	COG1246@1|root,COG1246@2|Bacteria,2GJBT@201174|Actinobacteria	201174|Actinobacteria	E	N-acetylglutamate synthase	argA	GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
k59_41338_1	933262.AXAM01000006_gene1868	6.74e-35	136.0	COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,42P23@68525|delta/epsilon subdivisions,2WK75@28221|Deltaproteobacteria,2MIZ4@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K13895	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1,OppC_N
k59_98253_1	570967.JMLV01000001_gene2799	8.25e-99	295.0	2DG8R@1|root,2ZUYV@2|Bacteria,1R8VA@1224|Proteobacteria,2VGKJ@28211|Alphaproteobacteria,2JZ9B@204441|Rhodospirillales	204441|Rhodospirillales	H	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
k59_1375903_1	1496688.ER33_03740	1.95e-08	60.5	COG0568@1|root,COG0568@2|Bacteria,1GBV9@1117|Cyanobacteria,22S9S@167375|Cyanobium	1117|Cyanobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_98261_1	1005048.CFU_2454	3.31e-81	250.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHMW@28216|Betaproteobacteria,473V0@75682|Oxalobacteraceae	28216|Betaproteobacteria	KLT	Protein tyrosine kinase	spkD	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_1091464_2	1040983.AXAE01000013_gene5788	0.000263	47.8	COG0463@1|root,COG0463@2|Bacteria,1QY6H@1224|Proteobacteria,2TXI8@28211|Alphaproteobacteria,43J5J@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Glycosyltransferase like family 2	exoU	-	-	ko:K16564	-	-	-	-	ko00000,ko01000,ko01003	-	GT2	-	Glycos_transf_2
k59_1859660_1	1121451.DESAM_21460	8.07e-105	316.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,42MRE@68525|delta/epsilon subdivisions,2WIP0@28221|Deltaproteobacteria,2M81I@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_1728419_2	1121403.AUCV01000065_gene4168	1.37e-42	147.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB-2	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_920075_1	1123393.KB891316_gene1533	6.16e-153	440.0	COG0446@1|root,COG0446@2|Bacteria,1PVXQ@1224|Proteobacteria,2WBJS@28216|Betaproteobacteria,1KS2X@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1331406_1	338969.Rfer_0832	6.41e-87	273.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,4ABI0@80864|Comamonadaceae	28216|Betaproteobacteria	O	Heat shock 70 kDa protein	-	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_274560_1	768671.ThimaDRAFT_3369	4.82e-62	210.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1WWG0@135613|Chromatiales	135613|Chromatiales	L	Helicase	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
k59_41367_1	1304275.C41B8_17291	1.62e-66	222.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	P-type atpase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
k59_391724_1	1121106.JQKB01000067_gene1799	1.39e-33	129.0	COG3547@1|root,COG3547@2|Bacteria,1Q4TE@1224|Proteobacteria,2TT7C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_730815_1	2340.JV46_20780	4.08e-25	102.0	COG1073@1|root,COG1073@2|Bacteria,1N1WH@1224|Proteobacteria,1S9JK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	DUF3530
k59_1331409_1	367299.JOEE01000008_gene427	1.52e-97	301.0	COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria,4FEE6@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_1020140_1	697282.Mettu_1826	4.04e-50	168.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,1RQPK@1236|Gammaproteobacteria,1XEER@135618|Methylococcales	135618|Methylococcales	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
k59_1020140_2	396588.Tgr7_2074	7.96e-78	253.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1WWAD@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_274567_1	1304880.JAGB01000005_gene2444	3.45e-59	201.0	COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,248A9@186801|Clostridia	186801|Clostridia	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_1785954_2	1499967.BAYZ01000076_gene756	2.81e-55	180.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
k59_1436070_1	435830.HMPREF0045_00539	0.000827	45.4	2ETNE@1|root,33M65@2|Bacteria,2HK4Z@201174|Actinobacteria,4D4P6@85005|Actinomycetales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1020146_1	1502851.FG93_03911	6.08e-73	235.0	COG0318@1|root,COG0318@2|Bacteria,1QVGC@1224|Proteobacteria,2TWFC@28211|Alphaproteobacteria,3K70M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding
k59_144015_1	1249627.D779_3291	2.06e-117	344.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,1RVJU@1236|Gammaproteobacteria,1WXJS@135613|Chromatiales	135613|Chromatiales	I	Poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009058,GO:0016234,GO:0042618,GO:0042619,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0070088,GO:0071704,GO:1901440,GO:1901441,GO:1901576	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_785288_1	1122194.AUHU01000012_gene372	2.9e-31	125.0	COG3291@1|root,COG3401@1|root,COG3291@2|Bacteria,COG3401@2|Bacteria,1R75J@1224|Proteobacteria,1S0RA@1236|Gammaproteobacteria,4666B@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	FG-GAP repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6
k59_1091482_2	1169154.KB897783_gene4595	9.71e-39	152.0	COG5650@1|root,COG5650@2|Bacteria,2GN1J@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
k59_319991_1	1121434.AULY01000006_gene749	7.35e-94	291.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2M833@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	-	-	1.12.1.3,1.6.5.2,1.6.5.3	ko:K00124,ko:K00335,ko:K00355,ko:K18331	ko00130,ko00190,ko00630,ko00680,ko01100,ko01110,ko01120,ko01200,ko05200,ko05225,ko05418,map00130,map00190,map00630,map00680,map01100,map01110,map01120,map01200,map05200,map05225,map05418	M00144	R00519,R02964,R03643,R03816,R11945	RC00061,RC00819,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_1375933_1	743718.Isova_1748	2.76e-217	619.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,4F3Z4@85017|Promicromonosporaceae	201174|Actinobacteria	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_99409_2	1049564.TevJSym_bh00110	1.95e-113	337.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,1J577@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
k59_1729055_2	1167006.UWK_02894	2.45e-36	130.0	COG1014@1|root,COG1014@2|Bacteria,1N53C@1224|Proteobacteria,42S8J@68525|delta/epsilon subdivisions,2WQ37@28221|Deltaproteobacteria,2MPU7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
k59_672973_1	497964.CfE428DRAFT_2287	9.83e-58	193.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,46SH2@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Acetyltransferase (GNAT) domain	-	-	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Acetyltransf_1
k59_144693_1	420324.KI912026_gene4980	1.1e-08	53.5	29114@1|root,2ZNNR@2|Bacteria,1P7Z9@1224|Proteobacteria,2UNFR@28211|Alphaproteobacteria,1JVFI@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LPAM_2
k59_1616093_1	367299.JOEE01000005_gene3623	1.09e-62	203.0	COG0448@1|root,COG0448@2|Bacteria,2I2EF@201174|Actinobacteria,4FEM7@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_1616093_2	367299.JOEE01000005_gene3622	4.15e-48	160.0	COG2141@1|root,COG2141@2|Bacteria,2GPA5@201174|Actinobacteria,4FF7S@85021|Intrasporangiaceae	201174|Actinobacteria	C	tetrahydromethanopterin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1791153_2	435832.HMPREF0604_00370	7.98e-26	105.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2VIIY@28216|Betaproteobacteria,2KPN1@206351|Neisseriales	206351|Neisseriales	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_737202_1	367299.JOEE01000003_gene2802	5.42e-119	365.0	COG3280@1|root,COG3280@2|Bacteria,2GJTB@201174|Actinobacteria,4FFMG@85021|Intrasporangiaceae	201174|Actinobacteria	G	Maltooligosyl trehalose synthase	treY	GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
k59_1557865_1	1121405.dsmv_0619	6.55e-100	290.0	COG1146@1|root,COG1146@2|Bacteria,1RC9N@1224|Proteobacteria,42QXF@68525|delta/epsilon subdivisions,2WMRJ@28221|Deltaproteobacteria,2MJFT@213118|Desulfobacterales	28221|Deltaproteobacteria	C	reductase, beta subunit	aprB	-	1.8.99.2	ko:K00395	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	APS-reductase_C,Fer4,Fer4_9
k59_1025133_2	1165841.SULAR_10489	9.1e-17	83.2	COG0438@1|root,COG0438@2|Bacteria,1N9EV@1224|Proteobacteria,42PK2@68525|delta/epsilon subdivisions	1224|Proteobacteria	M	PFAM Glycosyl transferase, group 1	rfbU	-	2.4.1.349	ko:K12994,ko:K13001	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
k59_1557866_2	614083.AWQR01000053_gene3395	1.15e-43	161.0	COG5322@1|root,COG5322@2|Bacteria,1R60X@1224|Proteobacteria	1224|Proteobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	Semialdhyde_dh
k59_1869839_1	1049564.TevJSym_bo00190	1.45e-76	254.0	COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,1RQ9A@1236|Gammaproteobacteria,1J616@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	ko:K02569	-	-	-	-	ko00000	-	-	-	Cytochrom_NNT,EB_dh
k59_1616109_1	1306174.JODP01000006_gene3412	2.12e-31	124.0	COG2027@1|root,COG2027@2|Bacteria,2GJPH@201174|Actinobacteria	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	dacB	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
k59_1616109_2	1194972.MVAC_08729	5.3e-13	69.7	COG0668@1|root,COG0668@2|Bacteria,2GJ51@201174|Actinobacteria,235XY@1762|Mycobacteriaceae	201174|Actinobacteria	M	Mechanosensitive ion	mscS	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_1025136_1	1120971.AUCA01000045_gene1219	5.47e-36	132.0	COG3677@1|root,COG3677@2|Bacteria,1W3WV@1239|Firmicutes,4I1PN@91061|Bacilli	91061|Bacilli	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1507074_1	933262.AXAM01000007_gene2029	7.99e-115	338.0	COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,42P7D@68525|delta/epsilon subdivisions,2WJ6S@28221|Deltaproteobacteria,2MIXK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,SHOCT,zinc_ribbon_2
k59_1869846_1	1121396.KB893077_gene738	1.03e-102	319.0	COG0438@1|root,COG0438@2|Bacteria,1R3Q9@1224|Proteobacteria,42MQ2@68525|delta/epsilon subdivisions,2WM1F@28221|Deltaproteobacteria,2MQ1W@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyl transferases group 1	-	-	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
k59_1143858_1	1260251.SPISAL_06220	5.29e-140	417.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdZ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_1507076_1	909663.KI867150_gene1856	3.62e-45	159.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,42MZR@68525|delta/epsilon subdivisions,2WK6B@28221|Deltaproteobacteria,2MQRI@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	tRNA methyl transferase	trmU	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_1791168_1	1333998.M2A_1287	2.82e-28	115.0	COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,2U1JN@28211|Alphaproteobacteria,4BS2P@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	MlaD protein	MA20_08125	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_1791168_2	1323663.AROI01000006_gene2974	1.62e-93	283.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RQVA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	(ABC) transporter	mkl	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_1791168_3	1331060.RLDS_15230	2.98e-17	81.6	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria,2K10W@204457|Sphingomonadales	204457|Sphingomonadales	Q	ABC-type transport system involved in resistance to organic solvents, permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_1442102_1	1121929.KB898670_gene3008	4.77e-05	49.7	COG0715@1|root,COG0715@2|Bacteria,1TPAD@1239|Firmicutes,4HBR9@91061|Bacilli,4704V@74385|Gracilibacillus	91061|Bacilli	P	NMT1/THI5 like	M1-596	-	-	-	-	-	-	-	-	-	-	-	NMT1
k59_1791171_1	585531.HMPREF0063_10173	1.61e-59	200.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4DU79@85009|Propionibacteriales	201174|Actinobacteria	I	Malonate decarboxylase gamma subunit (MdcE)	-	-	2.1.3.1	ko:K17489	ko00640,map00640	-	R00353	RC00040	ko00000,ko00001,ko01000	-	-	-	Carboxyl_trans
k59_51079_2	105559.Nwat_0721	7.96e-29	111.0	COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,1RP5A@1236|Gammaproteobacteria,1WY1K@135613|Chromatiales	135613|Chromatiales	P	TIGRFAM 3'(2'),5'-bisphosphate nucleotidase	-	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
k59_108977_1	367299.JOEE01000001_gene1692	3.57e-157	451.0	COG1228@1|root,COG1228@2|Bacteria,2GJH4@201174|Actinobacteria,4FEDI@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Catalyzes the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
k59_108977_2	367299.JOEE01000001_gene1691	8.25e-51	174.0	COG0402@1|root,COG0402@2|Bacteria,2GZ2Q@201174|Actinobacteria,4FG5E@85021|Intrasporangiaceae	201174|Actinobacteria	F	N-formimino-L-glutamate deiminase	hutF	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_990079_1	1038858.AXBA01000040_gene3071	8.37e-85	260.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2TQQP@28211|Alphaproteobacteria,3EYBE@335928|Xanthobacteraceae	28211|Alphaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
k59_1791590_1	1035308.AQYY01000001_gene1460	6.99e-102	327.0	28HY3@1|root,2Z83I@2|Bacteria	2|Bacteria	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
k59_1098764_1	1288079.AUKN01000010_gene2238	4.38e-27	116.0	COG0582@1|root,COG0582@2|Bacteria,2GMMI@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
k59_51083_1	1121405.dsmv_3295	1.12e-104	312.0	COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,42MH1@68525|delta/epsilon subdivisions,2WJD7@28221|Deltaproteobacteria,2MI33@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Na transporting methylmalonyl-CoA oxaloacetate decarboxylase beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
k59_1442612_1	713586.KB900536_gene1089	2.86e-129	374.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1WW30@135613|Chromatiales	135613|Chromatiales	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
k59_1442612_2	1538295.JY96_07630	2.32e-07	52.8	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2VHJ9@28216|Betaproteobacteria,1KIWK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_209274_1	1150864.MILUP08_43933	1.17e-68	235.0	2EX5R@1|root,33QGS@2|Bacteria,2ISYT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1870539_1	1112209.AHVZ01000007_gene2315	5.2e-25	94.7	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,3NPIV@468|Moraxellaceae	1236|Gammaproteobacteria	K	'Cold-shock' DNA-binding domain	cspA	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_1098774_1	471853.Bcav_1941	3.19e-42	145.0	COG0569@1|root,COG0569@2|Bacteria,2GKB9@201174|Actinobacteria	201174|Actinobacteria	P	PFAM TrkA-N domain protein	ceoC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_1098774_2	935839.JAGJ01000003_gene1384	1.29e-31	121.0	2AVV0@1|root,31MNQ@2|Bacteria,2GJKP@201174|Actinobacteria,4F4AR@85017|Promicromonosporaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3159
k59_990102_1	1123261.AXDW01000010_gene441	1.55e-23	100.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1X3R5@135614|Xanthomonadales	135614|Xanthomonadales	JKL	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C,RhlB
k59_854654_1	349521.HCH_05300	1.67e-58	196.0	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,1XHYN@135619|Oceanospirillales	135619|Oceanospirillales	D	Reduces the stability of FtsZ polymers in the presence of ATP	zapE	-	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
k59_1558424_1	1304885.AUEY01000001_gene3190	5.79e-43	150.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M97@68525|delta/epsilon subdivisions,2WJB4@28221|Deltaproteobacteria,2MJB7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	hmcB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4,Fer4_7
k59_1382656_1	525897.Dbac_3444	1.69e-54	192.0	COG0574@1|root,COG0745@1|root,COG0784@1|root,COG0574@2|Bacteria,COG0745@2|Bacteria,COG0784@2|Bacteria,1N38V@1224|Proteobacteria,42MWC@68525|delta/epsilon subdivisions,2WKAZ@28221|Deltaproteobacteria,2M7TZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2,PPDK_N
k59_209278_1	42256.RradSPS_0576	3.35e-46	160.0	COG2181@1|root,COG2181@2|Bacteria,2GJVI@201174|Actinobacteria,4CT0W@84995|Rubrobacteria	84995|Rubrobacteria	C	nitrate reductase, gamma subunit	-	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
k59_990112_1	1116472.MGMO_153c00050	7.47e-42	157.0	COG0841@1|root,COG0841@2|Bacteria,1QXYC@1224|Proteobacteria,1T3KA@1236|Gammaproteobacteria,1XH1H@135618|Methylococcales	135618|Methylococcales	V	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	MMPL
k59_1442631_1	379731.PST_0001	3.27e-61	202.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1Z1T4@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_790643_1	1304883.KI912532_gene32	4.94e-93	283.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2VH9Q@28216|Betaproteobacteria,2KUWH@206389|Rhodocyclales	206389|Rhodocyclales	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_560844_1	1163617.SCD_n01497	5.48e-71	219.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VIKC@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	sdhB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0022900,GO:0022904,GO:0044237,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_17,Fer4_8
k59_560844_2	1123073.KB899244_gene428	0.000271	41.6	COG2938@1|root,COG2938@2|Bacteria	2|Bacteria	C	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH	sdhE	GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006105,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016043,GO:0016999,GO:0017013,GO:0017144,GO:0018065,GO:0018293,GO:0019538,GO:0019752,GO:0022607,GO:0034552,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0043648,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0045333,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072350,GO:1901564	1.3.5.1,1.3.5.4	ko:K00240,ko:K09159	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000,ko02048	-	-	-	Sdh5
k59_1870560_2	1167006.UWK_02818	2.55e-28	107.0	COG1810@1|root,COG1810@2|Bacteria,1RG9Q@1224|Proteobacteria,42S52@68525|delta/epsilon subdivisions,2WNTC@28221|Deltaproteobacteria,2MK0C@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	DUF166
k59_1870560_3	933262.AXAM01000027_gene2088	2.61e-43	143.0	COG1810@1|root,COG1810@2|Bacteria,1RG9Q@1224|Proteobacteria,42S52@68525|delta/epsilon subdivisions,2WNTC@28221|Deltaproteobacteria,2MK0C@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	DUF166
k59_1507622_1	1266914.ATUK01000010_gene1610	6.83e-83	250.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,1WW34@135613|Chromatiales	135613|Chromatiales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_1734846_1	290399.Arth_0897	2.56e-41	138.0	COG0662@1|root,COG0662@2|Bacteria,2IKT6@201174|Actinobacteria	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_1734846_2	1463825.JNXC01000008_gene1191	5.23e-27	103.0	COG0346@1|root,COG0346@2|Bacteria,2IFKS@201174|Actinobacteria,4E5EV@85010|Pseudonocardiales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
k59_1442639_1	1713.JOFV01000004_gene3295	3.24e-108	325.0	COG0165@1|root,COG0165@2|Bacteria,2GJ2A@201174|Actinobacteria,4F1Z3@85016|Cellulomonadaceae	201174|Actinobacteria	E	Argininosuccinate lyase C-terminal	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_209295_1	1198232.CYCME_1046	3.07e-132	405.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,45ZXM@72273|Thiotrichales	72273|Thiotrichales	C	2-oxoglutarate dehydrogenase, E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1677615_2	765912.Thimo_1471	5.25e-41	138.0	COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,1S91G@1236|Gammaproteobacteria,1WZ1N@135613|Chromatiales	135613|Chromatiales	T	Belongs to the BolA IbaG family	-	-	-	ko:K05527	-	-	-	-	ko00000,ko03000	-	-	-	BolA
k59_1677615_3	319224.Sputcn32_3333	1.31e-36	135.0	COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,2Q8Y2@267890|Shewanellaceae	1236|Gammaproteobacteria	E	TIGRFAM amino acid carrier protein	dagA	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_854678_1	998674.ATTE01000001_gene4393	9.19e-50	166.0	COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,1S2TG@1236|Gammaproteobacteria,460KN@72273|Thiotrichales	72273|Thiotrichales	S	of the beta-lactamase superfamily I	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_854678_2	1049564.TevJSym_ax00180	3.43e-58	194.0	COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,1RZVF@1236|Gammaproteobacteria,1JBWE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	NlpB/DapX lipoprotein	bamC	-	-	ko:K07287	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	Lipoprotein_18
k59_619472_1	1249627.D779_2374	3.72e-99	303.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1WWIC@135613|Chromatiales	135613|Chromatiales	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
k59_1025590_1	1001240.GY21_03905	1.29e-47	162.0	COG0650@1|root,COG0650@2|Bacteria,2GJFM@201174|Actinobacteria,4FPM3@85023|Microbacteriaceae	201174|Actinobacteria	C	NADH dehydrogenase	hycD	-	-	ko:K12138	-	-	-	-	ko00000,ko01000	-	-	-	NADHdh
k59_1025590_2	243159.AFE_2151	8.25e-10	63.5	COG4237@1|root,COG4237@2|Bacteria,1NAT8@1224|Proteobacteria,1RRYF@1236|Gammaproteobacteria,2NCN2@225057|Acidithiobacillales	225057|Acidithiobacillales	C	hydrogenase 4 membrane	-	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
k59_1507637_1	471853.Bcav_3282	4.83e-24	99.8	COG1194@1|root,COG1194@2|Bacteria,2GJD9@201174|Actinobacteria	201174|Actinobacteria	L	adenine glycosylase	mutY	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_1791629_1	398580.Dshi_1220	1.61e-49	169.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2TT5Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	MA20_43200	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
k59_1791629_2	1469245.JFBG01000014_gene2026	1.1e-47	158.0	2C1YH@1|root,32R9E@2|Bacteria,1RF0Z@1224|Proteobacteria	1224|Proteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
k59_1616728_1	981384.AEYW01000001_gene1602	4.16e-150	441.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_679130_1	102125.Xen7305DRAFT_00009510	5.97e-115	354.0	COG5361@1|root,COG5361@2|Bacteria,1G6ZF@1117|Cyanobacteria,3VKJ9@52604|Pleurocapsales	1117|Cyanobacteria	S	Neurotransmitter-gated ion-channel ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Neur_chan_LBD
k59_326536_1	65497.JODV01000013_gene2302	4.45e-07	52.0	COG2135@1|root,COG2135@2|Bacteria,2GKY8@201174|Actinobacteria,4E13E@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the SOS response-associated peptidase family	yedK	-	-	-	-	-	-	-	-	-	-	-	SRAP
k59_326536_2	768671.ThimaDRAFT_2481	6.57e-40	139.0	COG0433@1|root,COG0433@2|Bacteria,1R98T@1224|Proteobacteria,1RYTG@1236|Gammaproteobacteria,1WZ6J@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4400)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4400
k59_1558469_1	288000.BBta_3803	6.54e-11	68.6	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,2TR6W@28211|Alphaproteobacteria,3K2KP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_443634_1	1201290.M902_2225	0.000397	43.1	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,42M0Z@68525|delta/epsilon subdivisions,2MTZP@213481|Bdellovibrionales,2WK36@28221|Deltaproteobacteria	213481|Bdellovibrionales	P	PFAM Bile acid sodium symporter	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
k59_443634_2	1260251.SPISAL_00485	5.54e-42	143.0	COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,1S2YD@1236|Gammaproteobacteria,1WY4X@135613|Chromatiales	135613|Chromatiales	T	low molecular weight	-	-	1.20.4.1	ko:K03741,ko:K03892	-	-	-	-	ko00000,ko01000,ko03000	-	-	-	HTH_5,LMWPc
k59_1144361_1	1167006.UWK_01093	8.26e-49	164.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,42NGT@68525|delta/epsilon subdivisions,2WK3E@28221|Deltaproteobacteria,2MI23@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1875	Ham1p_like
k59_150859_2	177437.HRM2_45240	1.06e-31	115.0	COG0640@1|root,COG0640@2|Bacteria,1MZT1@1224|Proteobacteria,42V3T@68525|delta/epsilon subdivisions,2WS3M@28221|Deltaproteobacteria,2MNP9@213118|Desulfobacterales	28221|Deltaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892,ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
k59_1558470_1	1116369.KB890024_gene1219	8.88e-107	341.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2TRQ2@28211|Alphaproteobacteria,43KPP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_990176_1	1123354.AUDR01000015_gene351	1.33e-45	151.0	COG1371@1|root,COG1371@2|Bacteria	2|Bacteria	J	PFAM Archease protein family (DUF101 UPF0211)	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Archease
k59_990176_2	506534.Rhein_2740	0.000113	45.4	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,1RMW7@1236|Gammaproteobacteria,1WYD3@135613|Chromatiales	135613|Chromatiales	K	PFAM Response regulator receiver domain	-	-	-	ko:K07662	ko01503,ko02020,map01503,map02020	M00447,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1677629_1	1122134.KB893650_gene584	1.18e-152	452.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1XP2X@135619|Oceanospirillales	135619|Oceanospirillales	S	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
k59_1677629_2	1254432.SCE1572_14460	1.06e-20	90.5	COG1720@1|root,COG2026@1|root,COG1720@2|Bacteria,COG2026@2|Bacteria,1MUF0@1224|Proteobacteria,42T7R@68525|delta/epsilon subdivisions,2WNQ2@28221|Deltaproteobacteria,2Z1S5@29|Myxococcales	28221|Deltaproteobacteria	DJ	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
k59_1442671_1	377629.TERTU_0366	1.26e-64	202.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,1S5VH@1236|Gammaproteobacteria,2PP0G@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	H	Dihydrofolate reductase	folA	GO:0000166,GO:0003674,GO:0003824,GO:0004146,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0008150,GO:0008152,GO:0016491,GO:0016645,GO:0016646,GO:0019842,GO:0031406,GO:0033218,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050661,GO:0050662,GO:0050896,GO:0051870,GO:0051871,GO:0055114,GO:0070401,GO:0070402,GO:0072341,GO:0097159,GO:1901265,GO:1901363	1.5.1.3	ko:K00287,ko:K18590	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	br01600,ko00000,ko00001,ko00002,ko01000,ko01504	-	-	iECBD_1354.ECBD_3567,iECDH1ME8569_1439.ECDH1ME8569_0047,iECNA114_1301.ECNA114_0036,iEcDH1_1363.EcDH1_3551,iEcSMS35_1347.EcSMS35_0050,iG2583_1286.G2583_0050,iJN746.PP_5132,iNRG857_1313.NRG857_00250,iUMN146_1321.UM146_23020	DHFR_1
k59_1098825_1	59374.Fisuc_1007	1.85e-27	116.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	ymxG	-	-	ko:K07263,ko:K07623	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1870630_1	91464.S7335_5130	5.13e-52	183.0	COG0364@1|root,COG0364@2|Bacteria,1G0K9@1117|Cyanobacteria,1GYST@1129|Synechococcus	1117|Cyanobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_990196_1	886293.Sinac_4145	1.24e-14	77.8	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_8,WD40
k59_1342409_1	491205.JARQ01000001_gene1002	5.93e-49	173.0	COG1574@1|root,COG1574@2|Bacteria,4NFMV@976|Bacteroidetes,1HZ70@117743|Flavobacteriia,3ZRDB@59732|Chryseobacterium	976|Bacteroidetes	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_333727_1	314265.R2601_02348	4.71e-43	154.0	COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,2TTZ2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	HP	ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components	fhuC	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_1213996_1	1379270.AUXF01000006_gene192	7.22e-64	214.0	COG1530@1|root,COG1530@2|Bacteria,1ZSZS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Ribonuclease E/G family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
k59_1742072_1	1187851.A33M_3193	5.98e-64	207.0	COG1063@1|root,COG1063@2|Bacteria,1QTU5@1224|Proteobacteria,2TW9Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	yphC	-	1.1.1.368	ko:K07538	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05581	RC00850	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
k59_1150495_1	56780.SYN_02160	2.77e-106	320.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,2MQ57@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_157756_1	472759.Nhal_0533	4.6e-49	168.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1WW0V@135613|Chromatiales	135613|Chromatiales	M	lipoprotein releasing system, transmembrane protein, LolC E family	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_157756_2	519989.ECTPHS_10671	1.94e-94	284.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1WVXB@135613|Chromatiales	135613|Chromatiales	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
k59_333732_1	1123392.AQWL01000005_gene3056	1.99e-06	49.7	COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2VJ3B@28216|Betaproteobacteria,1KRYE@119069|Hydrogenophilales	119069|Hydrogenophilales	P	TOBE domain	-	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
k59_333732_2	1049564.TevJSym_aq00510	6.67e-26	100.0	2CIC4@1|root,3328Z@2|Bacteria,1N7FS@1224|Proteobacteria,1SEFI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_333732_3	105559.Nwat_0762	7.64e-14	68.6	COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,1S3XT@1236|Gammaproteobacteria,1X0S8@135613|Chromatiales	135613|Chromatiales	M	PFAM Lytic transglycosylase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_744675_1	1341157.RF007C_03155	8.01e-50	165.0	COG2148@1|root,COG2148@2|Bacteria,1TP7V@1239|Firmicutes,25AZD@186801|Clostridia,3WQ0Y@541000|Ruminococcaceae	186801|Clostridia	M	Bacterial sugar transferase	pglB	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
k59_744675_2	485918.Cpin_2370	1.99e-06	52.8	COG3594@1|root,COG3594@2|Bacteria,4PAXA@976|Bacteroidetes,1IUGA@117747|Sphingobacteriia	976|Bacteroidetes	G	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_333733_1	338969.Rfer_0480	1.36e-05	46.6	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2VHUQ@28216|Betaproteobacteria,4AAAA@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM FAD linked oxidase domain protein	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_333733_2	305700.B447_17701	5.46e-67	218.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,2KUI1@206389|Rhodocyclales	206389|Rhodocyclales	C	Glycolate oxidase subunit GlcD	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_333735_1	690850.Desaf_3306	2.83e-23	99.0	COG3293@1|root,COG3293@2|Bacteria,1R5NV@1224|Proteobacteria,430FR@68525|delta/epsilon subdivisions,2WVKI@28221|Deltaproteobacteria,2MFEK@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2,DUF4096
k59_1684256_1	765912.Thimo_1117	4.17e-125	366.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1WXI2@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_1797655_1	1189612.A33Q_0084	4.26e-14	77.4	COG4974@1|root,COG4974@2|Bacteria,4NGE1@976|Bacteroidetes,47KKB@768503|Cytophagia	976|Bacteroidetes	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_1106484_1	1122925.KB895383_gene3389	4.59e-16	77.4	COG1643@1|root,COG1643@2|Bacteria,1TPET@1239|Firmicutes,4HE8W@91061|Bacilli,26U7B@186822|Paenibacillaceae	91061|Bacilli	L	ATP-dependent helicase	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_1106484_2	565045.NOR51B_1193	1.65e-61	202.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1J5IY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system, permease component	VP1997	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_333755_1	269799.Gmet_1168	8.45e-34	132.0	COG1624@1|root,COG1624@2|Bacteria,1PEQT@1224|Proteobacteria,42P5A@68525|delta/epsilon subdivisions,2WKPP@28221|Deltaproteobacteria,43UIQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	-	-	-	-	-	-	-	-	-	-	DisA_N,YbbR
k59_744699_1	1304865.JAGF01000001_gene1856	2.48e-65	218.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4F0X8@85016|Cellulomonadaceae	201174|Actinobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_333757_1	1121413.JMKT01000005_gene999	8.24e-77	239.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42SM4@68525|delta/epsilon subdivisions,2WPVD@28221|Deltaproteobacteria,2MGHY@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1389368_1	1032480.MLP_10710	2.18e-43	154.0	COG1840@1|root,COG1840@2|Bacteria,2HZ71@201174|Actinobacteria,4DQ1H@85009|Propionibacteriales	201174|Actinobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
k59_216022_1	696281.Desru_0556	9.11e-54	181.0	COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,2611T@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gluD	GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0055114,GO:0071704,GO:1901564	1.4.1.2,1.4.1.3,1.4.1.4	ko:K00260,ko:K00261,ko:K00262	ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_1565157_1	1453501.JELR01000001_gene3242	1.5e-22	102.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVS@1236|Gammaproteobacteria,46674@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA
k59_626561_1	717231.Flexsi_2316	2.1e-34	133.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
k59_1389378_1	1232410.KI421418_gene2310	5.02e-92	280.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42MNA@68525|delta/epsilon subdivisions,2WK7Z@28221|Deltaproteobacteria,43S2J@69541|Desulfuromonadales	28221|Deltaproteobacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_567822_1	573370.DMR_17650	9.4e-06	50.4	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,42MGU@68525|delta/epsilon subdivisions,2WIVG@28221|Deltaproteobacteria,2M899@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_567822_2	1384056.N787_00920	1.82e-62	214.0	COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1X3P0@135614|Xanthomonadales	135614|Xanthomonadales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_1033408_1	1038860.AXAP01000020_gene5661	9.25e-92	285.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2TRN0@28211|Alphaproteobacteria,3JSTM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_509334_1	118163.Ple7327_0643	5.22e-70	224.0	COG2843@1|root,COG2843@2|Bacteria,1G20Q@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
k59_1280884_1	1260251.SPISAL_00380	1.33e-56	193.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1WXGA@135613|Chromatiales	135613|Chromatiales	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1389394_1	1448389.BAVQ01000015_gene4121	8.85e-55	182.0	COG4447@1|root,COG4447@2|Bacteria,2GN53@201174|Actinobacteria	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
k59_333803_1	765912.Thimo_0557	1.42e-06	48.9	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,1WWRX@135613|Chromatiales	135613|Chromatiales	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_333803_3	572477.Alvin_1841	6.61e-12	62.8	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,1S61A@1236|Gammaproteobacteria,1WYDV@135613|Chromatiales	135613|Chromatiales	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
k59_744738_1	1035308.AQYY01000001_gene3081	2.24e-62	193.0	COG0292@1|root,COG0292@2|Bacteria,1V6DB@1239|Firmicutes,24JBJ@186801|Clostridia,2627I@186807|Peptococcaceae	186801|Clostridia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
k59_509352_1	876269.ARWA01000001_gene2557	4.93e-11	62.0	2ED3M@1|root,3370H@2|Bacteria,1NB6I@1224|Proteobacteria,2UE8V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_509352_2	520999.PROVALCAL_03796	5.23e-18	80.5	COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,1RQ9A@1236|Gammaproteobacteria,3Z860@586|Providencia	1236|Gammaproteobacteria	C	Cytochrome c-type protein	napC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0044464,GO:0045333,GO:0055114,GO:0071944	-	ko:K02569	-	-	-	-	ko00000	-	-	iEcolC_1368.EcolC_1448	Cytochrom_NNT
k59_1033433_1	933262.AXAM01000018_gene1009	2.49e-85	273.0	COG0501@1|root,COG3063@1|root,COG0501@2|Bacteria,COG3063@2|Bacteria,1R5A7@1224|Proteobacteria,42MP6@68525|delta/epsilon subdivisions,2WK92@28221|Deltaproteobacteria,2MIHI@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_11,TPR_17
k59_1389404_1	1121935.AQXX01000134_gene3578	2.07e-136	405.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1XHB9@135619|Oceanospirillales	135619|Oceanospirillales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_1150573_1	1123392.AQWL01000004_gene2648	2.19e-67	218.0	28HU5@1|root,2Z80X@2|Bacteria,1R55N@1224|Proteobacteria,2VI32@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TIGRFAM TIGR03790 family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_216064_1	1027273.GZ77_16765	6.56e-57	187.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1XIB9@135619|Oceanospirillales	135619|Oceanospirillales	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_216064_2	631362.Thi970DRAFT_02133	1.42e-22	89.7	COG3116@1|root,COG3116@2|Bacteria,1NI3C@1224|Proteobacteria,1SGSB@1236|Gammaproteobacteria,1WZ00@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsL	-	-	ko:K03586	-	-	-	-	ko00000,ko03036	-	-	-	FtsL
k59_1565206_1	1254432.SCE1572_03070	1.39e-77	258.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2YUEA@29|Myxococcales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1033438_1	935839.JAGJ01000001_gene1074	1.63e-173	514.0	COG0514@1|root,COG1205@1|root,COG0514@2|Bacteria,COG1205@2|Bacteria,2GJJ6@201174|Actinobacteria,4F3SR@85017|Promicromonosporaceae	201174|Actinobacteria	L	Domain of unknown function (DUF1998)	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
k59_509372_1	335283.Neut_1567	6.37e-93	283.0	COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,2VJ5V@28216|Betaproteobacteria,372AU@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_861312_1	749927.AMED_0551	1.87e-14	79.7	COG0367@1|root,COG0367@2|Bacteria,2GJIM@201174|Actinobacteria,4E1WP@85010|Pseudonocardiales	201174|Actinobacteria	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_1623423_1	870187.Thini_4167	4.08e-95	290.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,46068@72273|Thiotrichales	72273|Thiotrichales	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_216079_1	446471.Xcel_3320	2.36e-47	164.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,4F3Y1@85017|Promicromonosporaceae	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1106559_1	298386.PBPRB1849	2.32e-84	262.0	COG3367@1|root,COG3367@2|Bacteria,1MVEX@1224|Proteobacteria,1RNVG@1236|Gammaproteobacteria,1XT33@135623|Vibrionales	135623|Vibrionales	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
k59_1515125_1	1134474.O59_003720	1.99e-35	131.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1FGWY@10|Cellvibrio	1236|Gammaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
k59_1565226_1	1121451.DESAM_22654	1.83e-21	97.8	COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,42QJ2@68525|delta/epsilon subdivisions,2WM78@28221|Deltaproteobacteria,2M8CT@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	VWA-like domain (DUF2201)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2201,DUF2201_N
k59_1150593_2	338963.Pcar_1381	1.98e-53	178.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,42MM6@68525|delta/epsilon subdivisions,2WJ53@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve
k59_1623431_1	243365.CV_4184	3.7e-31	112.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2VU1C@28216|Betaproteobacteria,2KRGC@206351|Neisseriales	206351|Neisseriales	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_1623431_2	713586.KB900536_gene1167	6.23e-67	210.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,1RMGR@1236|Gammaproteobacteria,1WWAW@135613|Chromatiales	135613|Chromatiales	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_567887_1	648757.Rvan_0082	6.95e-08	54.7	COG1216@1|root,COG1216@2|Bacteria,1N6DH@1224|Proteobacteria,2TWBP@28211|Alphaproteobacteria,3N8ET@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1214137_1	985054.JQEZ01000001_gene2722	5.61e-14	72.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2TRSV@28211|Alphaproteobacteria,4NBPA@97050|Ruegeria	28211|Alphaproteobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
k59_1214137_2	1333998.M2A_2143	2.12e-43	146.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,2U58D@28211|Alphaproteobacteria,4BQ8N@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
k59_293227_1	720554.Clocl_0722	4.32e-27	116.0	COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia,3WHJ3@541000|Ruminococcaceae	186801|Clostridia	E	ABC-type oligopeptide transport system periplasmic component	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
k59_333853_1	1268635.Loa_02597	6.63e-54	182.0	COG4467@1|root,COG4467@2|Bacteria,1QW8C@1224|Proteobacteria,1S2JX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_626643_3	1245471.PCA10_48010	1.18e-20	83.2	2EGSV@1|root,33AIZ@2|Bacteria,1NGPG@1224|Proteobacteria,1SGM3@1236|Gammaproteobacteria,1YGYC@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Cysteine-rich CPXCG	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_CPXG
k59_626643_4	1131553.JIBI01000003_gene1690	3.86e-05	47.4	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2VHBB@28216|Betaproteobacteria,372JD@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	hemN2	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_216097_1	1218084.BBJK01000149_gene7525	3.41e-72	229.0	COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,2WB1W@28216|Betaproteobacteria,1K4YH@119060|Burkholderiaceae	28216|Betaproteobacteria	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C
k59_450674_1	631454.N177_0494	4.37e-219	622.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TR1V@28211|Alphaproteobacteria,1JPWJ@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	nuoEF	-	1.17.1.9	ko:K00122	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_509397_1	452637.Oter_1389	2.72e-77	254.0	COG0515@1|root,COG0515@2|Bacteria,46VB0@74201|Verrucomicrobia,3K8AK@414999|Opitutae	414999|Opitutae	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_567902_1	471853.Bcav_4182	1.19e-119	371.0	COG0744@1|root,COG2815@1|root,COG0744@2|Bacteria,COG2815@2|Bacteria,2GK21@201174|Actinobacteria	201174|Actinobacteria	M	penicillin-binding protein	pbp5	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
k59_1214154_1	768671.ThimaDRAFT_0247	7.49e-132	384.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1WXIX@135613|Chromatiales	135613|Chromatiales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1515134_1	471853.Bcav_1207	7.13e-86	292.0	COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_1515134_2	1380354.JIAN01000006_gene1128	9.91e-72	245.0	COG3147@1|root,COG3147@2|Bacteria,2HC8A@201174|Actinobacteria,4F179@85016|Cellulomonadaceae	201174|Actinobacteria	S	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1515134_3	1095767.CAHD01000165_gene3018	4.57e-53	171.0	COG3824@1|root,COG3824@2|Bacteria,2IS6W@201174|Actinobacteria,4F2J2@85016|Cellulomonadaceae	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
k59_1515134_4	1123065.ATWL01000014_gene3490	1.98e-49	160.0	2C7XW@1|root,32RR4@2|Bacteria,2IQ5R@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3499)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3499
k59_567907_1	545264.KB898747_gene424	8.51e-27	107.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1WW43@135613|Chromatiales	135613|Chromatiales	J	TIGRFAM Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_1151691_1	1442599.JAAN01000014_gene3564	9.92e-18	84.0	COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,1X3QH@135614|Xanthomonadales	135614|Xanthomonadales	L	Belongs to the DnaA family. HdA subfamily	hda	-	-	ko:K10763	-	-	-	-	ko00000,ko03032	-	-	-	Bac_DnaA,IstB_IS21
k59_1151691_2	1249627.D779_2184	1.77e-12	66.2	COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,1SAHT@1236|Gammaproteobacteria,1WY27@135613|Chromatiales	135613|Chromatiales	I	PFAM CDP-alcohol phosphatidyltransferase	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_627973_1	637389.Acaty_c0783	4.43e-98	300.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,2NBT2@225057|Acidithiobacillales	225057|Acidithiobacillales	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
k59_1215518_1	1049564.TevJSym_ak01000	5.99e-89	274.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1J4KM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	aminopeptidase	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_1215518_2	396588.Tgr7_2763	5.57e-46	162.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1WW09@135613|Chromatiales	135613|Chromatiales	CH	Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	-	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_1390652_2	765914.ThisiDRAFT_2542	1.94e-08	58.9	COG3087@1|root,COG3087@2|Bacteria,1MYFG@1224|Proteobacteria,1SD3J@1236|Gammaproteobacteria,1WYSZ@135613|Chromatiales	135613|Chromatiales	D	PFAM Sporulation	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
k59_1215523_1	1227488.C477_01530	7.22e-36	132.0	COG0596@1|root,arCOG01648@2157|Archaea,2XW5K@28890|Euryarchaeota,23TTR@183963|Halobacteria	183963|Halobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
k59_1390653_1	1121468.AUBR01000039_gene1941	1.19e-100	307.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia	186801|Clostridia	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_1685798_1	1530186.JQEY01000010_gene2803	1.96e-100	301.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2TQP8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_1566448_1	314256.OG2516_18440	8.47e-15	80.1	COG2931@1|root,COG3210@1|root,COG4070@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria,2V8V8@28211|Alphaproteobacteria,2PFGF@252301|Oceanicola	28211|Alphaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1516524_1	1121479.AUBS01000005_gene2645	9.11e-06	46.6	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_343176_1	429009.Adeg_1937	1.14e-87	268.0	COG0798@1|root,COG0798@2|Bacteria,1TRMD@1239|Firmicutes,24958@186801|Clostridia,42FSU@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM Bile acid sodium symporter	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
k59_1044691_1	485918.Cpin_4837	4.86e-92	298.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,4NEK3@976|Bacteroidetes,1INMR@117747|Sphingobacteriia	976|Bacteroidetes	C	FAD linked oxidases, C-terminal domain	-	-	-	ko:K18930	-	-	-	-	ko00000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8
k59_1575475_1	96561.Dole_0135	8.82e-43	157.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,43BJ8@68525|delta/epsilon subdivisions,2X708@28221|Deltaproteobacteria,2MJ7A@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Transglycosylase	-	-	2.4.1.129,3.4.16.4	ko:K05366,ko:K21464	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
k59_695052_1	371731.Rsw2DRAFT_3294	8.87e-61	197.0	COG0518@1|root,COG0518@2|Bacteria,1MYXC@1224|Proteobacteria,2UBE9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	GMP synthase (glutamine-hydrolyzing) activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_695052_2	582899.Hden_0686	7.65e-09	58.2	COG0095@1|root,COG0095@2|Bacteria,1N1T8@1224|Proteobacteria,2U1PC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_1224148_2	1121020.JIAG01000002_gene821	9.04e-52	171.0	COG0785@1|root,COG0785@2|Bacteria,2IMP9@201174|Actinobacteria,1WBAV@1268|Micrococcaceae	201174|Actinobacteria	O	Cytochrome C biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1805602_1	1267005.KB911257_gene1065	9.06e-93	282.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2TT0J@28211|Alphaproteobacteria,3N6CY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_1224153_1	292564.Cyagr_1734	1.92e-45	157.0	COG1064@1|root,COG1064@2|Bacteria,1G0B9@1117|Cyanobacteria	1117|Cyanobacteria	C	alcohol dehydrogenase	-	-	-	ko:K12957	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_517026_1	1304885.AUEY01000003_gene544	3.43e-16	75.1	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,42VQ6@68525|delta/epsilon subdivisions,2WRTU@28221|Deltaproteobacteria,2MKPU@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
k59_517026_2	1121405.dsmv_2735	2.11e-97	294.0	COG0618@1|root,COG0618@2|Bacteria,1RAUQ@1224|Proteobacteria,42RKG@68525|delta/epsilon subdivisions,2WN0X@28221|Deltaproteobacteria,2MJ6U@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM phosphoesterase RecJ domain protein	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_225630_1	590998.Celf_0462	6.81e-82	263.0	COG1070@1|root,COG1070@2|Bacteria,2HDA8@201174|Actinobacteria	201174|Actinobacteria	G	PFAM carbohydrate kinase	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
k59_1399021_1	1120792.JAFV01000001_gene3899	1.72e-25	101.0	COG1802@1|root,COG1802@2|Bacteria,1RBIC@1224|Proteobacteria,2U60T@28211|Alphaproteobacteria,36YBZ@31993|Methylocystaceae	28211|Alphaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_1399021_2	1122929.KB908231_gene3608	2e-07	52.4	COG1638@1|root,COG1638@2|Bacteria,1MWAW@1224|Proteobacteria,2TV91@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	MA20_30160	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1694445_2	768671.ThimaDRAFT_2530	3.77e-129	377.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1WWT0@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_635333_1	471853.Bcav_2889	1.14e-121	364.0	COG3480@1|root,COG3480@2|Bacteria,2GJDD@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the peptidase S16 family	ylbL	-	-	ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	Lon_C,PDZ_2
k59_1224177_1	1336208.JADY01000005_gene1775	1.88e-112	336.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,2JPG4@204441|Rhodospirillales	204441|Rhodospirillales	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_1224177_2	34506.g1592	2.03e-26	106.0	COG0045@1|root,COG0074@1|root,KOG1255@2759|Eukaryota,KOG2799@2759|Eukaryota,38DG1@33154|Opisthokonta,3BA6W@33208|Metazoa,3CRD6@33213|Bilateria,40FSA@6231|Nematoda,1KYNA@119089|Chromadorea	33208|Metazoa	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits	-	-	6.2.1.4,6.2.1.5	ko:K01899	ko00020,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011	R00432,R00727	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_695089_1	1463841.JOIR01000015_gene6528	2.37e-10	61.2	COG1075@1|root,COG1075@2|Bacteria,2I090@201174|Actinobacteria	201174|Actinobacteria	S	Lecithin:cholesterol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	LCAT
k59_695089_2	526224.Bmur_1555	1.81e-19	85.9	COG0057@1|root,COG0057@2|Bacteria,2J5AD@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_1694454_1	765913.ThidrDRAFT_4026	3.89e-82	258.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RYB4@1236|Gammaproteobacteria,1WVUT@135613|Chromatiales	135613|Chromatiales	CP	PFAM NADH Ubiquinone plastoquinone	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_1224190_1	105425.BBPL01000012_gene1866	3.14e-71	226.0	COG3012@1|root,COG3012@2|Bacteria,2GJ7F@201174|Actinobacteria,2NG36@228398|Streptacidiphilus	201174|Actinobacteria	S	SEC-C motif	-	-	-	-	-	-	-	-	-	-	-	-	SEC-C
k59_1459395_1	497964.CfE428DRAFT_6231	1.23e-38	147.0	COG0745@1|root,COG5000@1|root,COG0745@2|Bacteria,COG5000@2|Bacteria,46S9G@74201|Verrucomicrobia	74201|Verrucomicrobia	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
k59_576290_1	105559.Nwat_0434	2.75e-56	196.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales	135613|Chromatiales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_4,PAS_9
k59_517061_1	765911.Thivi_1096	3.88e-62	212.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1WWWW@135613|Chromatiales	135613|Chromatiales	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
k59_1633704_1	2340.JV46_14340	5.67e-06	50.4	2C9YT@1|root,31Z2V@2|Bacteria,1RHIU@1224|Proteobacteria,1S6G3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_754610_1	1267005.KB911259_gene3901	3.55e-52	180.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2TRWB@28211|Alphaproteobacteria,3N6F1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_1158832_1	111781.Lepto7376_0812	9.2e-05	48.5	COG1729@1|root,COG1729@2|Bacteria,1GHEZ@1117|Cyanobacteria,1HHYN@1150|Oscillatoriales	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
k59_635369_1	558173.CDOO_01350	0.000272	49.7	COG0287@1|root,COG0287@2|Bacteria,2GKB4@201174|Actinobacteria,22JN7@1653|Corynebacteriaceae	201174|Actinobacteria	E	prephenate dehydrogenase	tyrA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.3.1.12	ko:K00210,ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
k59_1696304_1	2340.JV46_09860	5.34e-83	267.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,1J5MJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Ferrous iron transport protein B	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_1635530_1	572477.Alvin_1630	2.1e-33	132.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RZWQ@1236|Gammaproteobacteria,1WW2K@135613|Chromatiales	135613|Chromatiales	M	PFAM Transglycosylase SLT domain	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_227324_2	1238182.C882_3218	4.38e-20	91.3	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2TS99@28211|Alphaproteobacteria,2JPBD@204441|Rhodospirillales	204441|Rhodospirillales	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
k59_696647_1	396588.Tgr7_0332	1.52e-67	216.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXE7@135613|Chromatiales	135613|Chromatiales	GM	NAD-dependent epimerase dehydratase	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
k59_1635533_1	177437.HRM2_02630	3.19e-73	244.0	COG1026@1|root,COG1026@2|Bacteria,1MVDJ@1224|Proteobacteria,42MRG@68525|delta/epsilon subdivisions,2WJ5Q@28221|Deltaproteobacteria,2MINB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Peptidase M16C associated	PREP	-	-	ko:K06972	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M16C_assoc,Peptidase_M16,Peptidase_M16_C
k59_1577517_1	545276.KB898731_gene2295	4.2e-142	417.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1WWDG@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1752487_2	1123519.PSJM300_14515	2.07e-30	118.0	2DKZI@1|root,310D6@2|Bacteria,1QV1U@1224|Proteobacteria,1T269@1236|Gammaproteobacteria,1Z4F8@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	E3 Ubiquitin ligase	-	-	-	-	-	-	-	-	-	-	-	-	GIDE
k59_1160296_1	768671.ThimaDRAFT_3333	2.3e-77	244.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,1WWKR@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases	cca	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
k59_227345_1	857087.Metme_1289	1.93e-77	242.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1XDR2@135618|Methylococcales	135618|Methylococcales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
k59_1752499_1	555779.Dthio_PD1186	1.58e-34	121.0	2DP9Z@1|root,3316S@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1460970_1	1121405.dsmv_2856	1.48e-14	80.1	COG3039@1|root,COG3039@2|Bacteria,1PKUP@1224|Proteobacteria,43ECD@68525|delta/epsilon subdivisions,2X0BQ@28221|Deltaproteobacteria,2MP4F@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1400918_1	768671.ThimaDRAFT_0880	1.52e-64	205.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,1WY2J@135613|Chromatiales	135613|Chromatiales	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_804836_1	754476.Q7A_688	1.62e-55	182.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,45ZU9@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
k59_344790_1	313603.FB2170_02200	1.89e-38	144.0	COG0624@1|root,COG0624@2|Bacteria,4NI66@976|Bacteroidetes,1HZ8W@117743|Flavobacteriia,2PH19@252356|Maribacter	976|Bacteroidetes	E	Peptidase dimerisation domain	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1400930_1	1249627.D779_3786	2.3e-80	242.0	COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,1S2DE@1236|Gammaproteobacteria,1WY01@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM TIGR00645 family protein	-	-	-	-	-	-	-	-	-	-	-	-	UPF0114
k59_1160317_1	314231.FP2506_14129	9.93e-56	191.0	COG0477@1|root,COG2814@2|Bacteria,1N2NP@1224|Proteobacteria,2TXTK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_696694_1	583355.Caka_1740	2.78e-08	60.1	2CAZH@1|root,2Z7RU@2|Bacteria,46V42@74201|Verrucomicrobia,3K7Z0@414999|Opitutae	414999|Opitutae	C	TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	-
k59_344812_1	582899.Hden_3318	6.81e-78	239.0	COG2917@1|root,COG2917@2|Bacteria	2|Bacteria	D	probably involved in intracellular septation	ispZ	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
k59_756368_1	177439.DP1199	1.54e-37	135.0	COG1014@1|root,COG1144@1|root,COG1014@2|Bacteria,COG1144@2|Bacteria,1N12F@1224|Proteobacteria,42NN1@68525|delta/epsilon subdivisions,2WQFN@28221|Deltaproteobacteria,2MKTB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,POR
k59_756368_2	2340.JV46_13040	9.67e-27	107.0	COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J85H@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N,Transketolase_C
k59_1460998_1	1120950.KB892740_gene2559	5.09e-47	154.0	COG0359@1|root,COG0359@2|Bacteria,2IKX7@201174|Actinobacteria,4DQKG@85009|Propionibacteriales	201174|Actinobacteria	J	binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
k59_1460998_2	1463825.JNXC01000001_gene5678	0.000132	41.2	COG0238@1|root,COG0238@2|Bacteria,2IQ92@201174|Actinobacteria,4E5E1@85010|Pseudonocardiales	201174|Actinobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
k59_1047032_1	469610.HMPREF0189_00397	1.39e-52	171.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2VHT5@28216|Betaproteobacteria,1KK0R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_1752535_2	525897.Dbac_1814	2.56e-25	108.0	COG2304@1|root,COG2885@1|root,COG2304@2|Bacteria,COG2885@2|Bacteria,1R8DG@1224|Proteobacteria,42NGC@68525|delta/epsilon subdivisions,2WMAP@28221|Deltaproteobacteria,2MGWU@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA,Phenol_MetA_deg,TSP_3,VWA
k59_518251_1	1266925.JHVX01000004_gene1153	6.5e-12	66.2	COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,2VUF4@28216|Betaproteobacteria,37383@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Biopolymer transport protein ExbD TolR	exbD2	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_696722_1	314345.SPV1_13844	3.33e-88	278.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria	1224|Proteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_169417_1	879243.Poras_0200	7.71e-42	154.0	COG1109@1|root,COG1109@2|Bacteria,4NG3H@976|Bacteroidetes,2FM6E@200643|Bacteroidia,22W7N@171551|Porphyromonadaceae	976|Bacteroidetes	G	Phosphoglucosamine mutase	glmM	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_344848_1	446466.Cfla_0251	4.31e-97	289.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4F0VG@85016|Cellulomonadaceae	201174|Actinobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_577796_1	768671.ThimaDRAFT_0910	1.04e-126	367.0	COG0348@1|root,COG0348@2|Bacteria,1MWR5@1224|Proteobacteria,1SJST@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
k59_1577607_1	1268240.ATFI01000004_gene4447	1.79e-68	233.0	COG3250@1|root,COG3507@1|root,COG3250@2|Bacteria,COG3507@2|Bacteria,4NGZD@976|Bacteroidetes,2G08E@200643|Bacteroidia,4ANAP@815|Bacteroidaceae	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Glyco_hydro_43
k59_1696437_1	593907.Celgi_1131	8.55e-18	87.4	COG5164@1|root,COG5164@2|Bacteria,2I2IU@201174|Actinobacteria,4F1NB@85016|Cellulomonadaceae	201174|Actinobacteria	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	GPDPase_memb
k59_1047097_1	441620.Mpop_2368	2.12e-76	269.0	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,1JS5X@119045|Methylobacteriaceae	28211|Alphaproteobacteria	QU	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
k59_1160426_1	232721.Ajs_2200	3.06e-108	324.0	COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,2VKAK@28216|Betaproteobacteria,4AJKJ@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3
k59_227451_1	391615.ABSJ01000026_gene114	1.48e-63	204.0	COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,1S50X@1236|Gammaproteobacteria,1J761@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
k59_227451_2	159087.Daro_0437	9.73e-28	109.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,2VM6F@28216|Betaproteobacteria,2KUQG@206389|Rhodocyclales	206389|Rhodocyclales	T	Serine/threonine phosphatases, family 2C, catalytic domain	pppL	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
k59_169467_1	13689.BV96_01895	1.44e-28	112.0	COG0565@1|root,COG2827@1|root,COG0565@2|Bacteria,COG2827@2|Bacteria,1N47Y@1224|Proteobacteria,2TS8J@28211|Alphaproteobacteria,2JZUG@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GIY-YIG,SpoU_methylase
k59_169467_2	1449342.JQMR01000001_gene2377	3.38e-26	108.0	COG3039@1|root,COG3039@2|Bacteria,1TRBK@1239|Firmicutes,4HDJU@91061|Bacilli	91061|Bacilli	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_636859_1	1249627.D779_1932	2.64e-27	103.0	COG1051@1|root,COG1051@2|Bacteria,1MWNH@1224|Proteobacteria,1S56W@1236|Gammaproteobacteria,1WYDD@135613|Chromatiales	135613|Chromatiales	F	pfam nudix	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
k59_1047118_2	1169161.KB897716_gene5844	8.27e-47	159.0	COG0785@1|root,COG0785@2|Bacteria,2IMP9@201174|Actinobacteria	201174|Actinobacteria	O	Cytochrome C biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1577668_1	314345.SPV1_06999	2.77e-45	160.0	COG2367@1|root,COG2367@2|Bacteria,1R4Y9@1224|Proteobacteria	1224|Proteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase2
k59_1577668_2	713586.KB900536_gene534	2.97e-30	122.0	COG0574@1|root,COG0574@2|Bacteria,1P35R@1224|Proteobacteria,1SWBY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
k59_1461088_1	933262.AXAM01000010_gene1389	9.97e-129	377.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,42KZA@68525|delta/epsilon subdivisions,2WJ1V@28221|Deltaproteobacteria,2MI99@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_3810_1	1123229.AUBC01000005_gene802	2.45e-44	157.0	COG1748@1|root,COG1748@2|Bacteria,1MY1G@1224|Proteobacteria,2TU0J@28211|Alphaproteobacteria,3JX70@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Saccharopine dehydrogenase C-terminal domain	lys1	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_3810_2	28532.XP_010555258.1	5.15e-10	60.8	COG3200@1|root,2QPP7@2759|Eukaryota,37JFZ@33090|Viridiplantae,3GDPA@35493|Streptophyta,3HR1X@3699|Brassicales	35493|Streptophyta	E	Phospho-2-dehydro-3-deoxyheptonate aldolase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
k59_1824129_1	1108045.GORHZ_126_00330	4.04e-67	220.0	COG1457@1|root,COG1457@2|Bacteria,2GKZN@201174|Actinobacteria,4GDQE@85026|Gordoniaceae	201174|Actinobacteria	U	Permease for cytosine/purines, uracil, thiamine, allantoin	-	-	-	-	-	-	-	-	-	-	-	-	Transp_cyt_pur
k59_1824138_1	2340.JV46_27860	7.65e-18	83.2	COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,1RMAV@1236|Gammaproteobacteria,1JBHG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Involved in arsenical resistance. Thought to form the channel of an arsenite pump	-	-	-	-	-	-	-	-	-	-	-	-	ArsB,CitMHS
k59_1824138_2	2340.JV46_27850	9.74e-41	140.0	COG0517@1|root,COG0517@2|Bacteria,1NJC6@1224|Proteobacteria,1SV2H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_413638_1	1380347.JNII01000009_gene1990	1.58e-32	118.0	2AY0M@1|root,31Q26@2|Bacteria,2IMBI@201174|Actinobacteria,4EW7U@85013|Frankiales	201174|Actinobacteria	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N,SHOCT
k59_885028_2	1304865.JAGF01000001_gene3688	8.59e-62	203.0	COG0079@1|root,COG0079@2|Bacteria,2GJ9W@201174|Actinobacteria,4F0SI@85016|Cellulomonadaceae	201174|Actinobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_356641_1	419610.Mext_0957	1.52e-10	69.3	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,2TR3Z@28211|Alphaproteobacteria,1JS6M@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Belongs to the PEP-utilizing enzyme family	ptsP	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_531287_1	926561.KB900618_gene312	5.73e-25	108.0	COG1033@1|root,COG1033@2|Bacteria	2|Bacteria	S	growth of symbiont in host cell	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	LolA_like,MMPL
k59_1000593_1	477228.YO5_12362	8.78e-19	84.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1YZPX@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	U	MotA TolQ ExbB proton channel family	exbB	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_1000593_2	1441930.Z042_21860	6.45e-25	107.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,40248@613|Serratia	1236|Gammaproteobacteria	S	Competence protein ComEC	ycaI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_1646807_1	2340.JV46_20200	3.34e-118	348.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_472495_1	290398.Csal_1235	4.75e-05	48.9	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1XINT@135619|Oceanospirillales	135619|Oceanospirillales	O	COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_472495_2	105559.Nwat_0645	4.25e-115	335.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,1WWC1@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM FeS assembly ATPase SufC	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
k59_356652_1	754476.Q7A_981	1.2e-49	167.0	COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria,460BF@72273|Thiotrichales	72273|Thiotrichales	G	PFAM pfkB family carbohydrate kinase	-	-	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_1000598_1	1122933.JNIY01000004_gene2525	8.38e-51	171.0	COG1253@1|root,COG1253@2|Bacteria,2GJ8X@201174|Actinobacteria,4F11U@85016|Cellulomonadaceae	201174|Actinobacteria	S	Domain of unknown function DUF21	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
k59_63176_1	1123401.JHYQ01000020_gene923	9.53e-54	185.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,4608P@72273|Thiotrichales	72273|Thiotrichales	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
k59_1411789_1	1049564.TevJSym_aw00120	6.61e-108	330.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1J5XD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	dsrL	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,Fer4_9,NADH_4Fe-4S,Pyr_redox_2
k59_707449_1	1437882.AZRU01000025_gene5837	3.98e-12	70.9	COG3249@1|root,COG3249@2|Bacteria,1N0PD@1224|Proteobacteria,1S9C4@1236|Gammaproteobacteria,1YEIB@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2066)	VV2512	-	-	ko:K09938	-	-	-	-	ko00000	-	-	-	DUF2066
k59_1177034_1	1380367.JIBC01000002_gene2567	2.82e-33	119.0	COG4311@1|root,COG4311@2|Bacteria,1MZC3@1224|Proteobacteria,2UC8C@28211|Alphaproteobacteria,3ZXKI@60136|Sulfitobacter	28211|Alphaproteobacteria	E	Sarcosine oxidase subunit delta	soxD	-	1.5.3.1	ko:K00304	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxD
k59_1177034_2	1266998.ATUJ01000001_gene2574	2.61e-52	177.0	COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,2TRM7@28211|Alphaproteobacteria,2PU4G@265|Paracoccus	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	soxB3	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
k59_1235757_1	1267005.KB911255_gene2584	4.26e-60	189.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,2TR3M@28211|Alphaproteobacteria,3N6JY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	HNH endonuclease	MA20_20605	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
k59_64439_1	557598.LHK_00732	1.87e-14	73.9	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2VI9P@28216|Betaproteobacteria,2KPEC@206351|Neisseriales	206351|Neisseriales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_64439_2	95619.PM1_0201005	1.51e-26	102.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Riboflavin synthase	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
k59_1177780_1	330214.NIDE3284	2.94e-46	176.0	COG3829@1|root,COG4191@1|root,COG5000@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,3J117@40117|Nitrospirae	40117|Nitrospirae	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HAMP,HATPase_c,HisKA,PAS_4
k59_1825409_2	1230476.C207_05541	9.08e-53	176.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2TR6G@28211|Alphaproteobacteria,3JRRD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_357957_1	572477.Alvin_1201	7.81e-128	381.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales	135613|Chromatiales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_1001320_1	471853.Bcav_2356	1.82e-87	266.0	COG0061@1|root,COG0061@2|Bacteria,2GKM2@201174|Actinobacteria	201174|Actinobacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006797,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_1001320_2	548479.HMPREF0573_11890	1.11e-08	55.5	COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria,4D32N@85005|Actinomycetales	201174|Actinobacteria	L	May be involved in recombinational repair of damaged DNA	recN	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
k59_1647666_1	7668.SPU_003061-tr	3.1e-104	343.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria	33208|Metazoa	E	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,SCAN,gag-asp_proteas,rve,zf-CCHC,zf-H2C2
k59_473343_2	1038860.AXAP01000027_gene1889	1.36e-48	172.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,3JSZE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1001324_1	648757.Rvan_0375	2.25e-59	204.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR3C@28211|Alphaproteobacteria,3N6KF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	pyruvate phosphate dikinase	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1353919_1	1232437.KL661986_gene3654	1.22e-60	196.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1706196_1	1249627.D779_4009	6.43e-85	263.0	COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,1RQ6N@1236|Gammaproteobacteria,1WWGR@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1706196_2	631362.Thi970DRAFT_02655	5.98e-43	155.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1RSFG@1236|Gammaproteobacteria,1WW9R@135613|Chromatiales	135613|Chromatiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_1297358_1	1095767.CAHD01000045_gene1386	7.4e-73	239.0	COG0247@1|root,COG0247@2|Bacteria,2GJ7M@201174|Actinobacteria	201174|Actinobacteria	C	Fe-S oxidoreductase	fadF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_649506_1	1232437.KL661988_gene190	7.66e-93	284.0	COG3303@1|root,COG3303@2|Bacteria,1QX6Q@1224|Proteobacteria,42MHA@68525|delta/epsilon subdivisions,2WMF3@28221|Deltaproteobacteria,2MK9F@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1
k59_1236613_1	1469245.JFBG01000013_gene1921	8.68e-31	117.0	COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,1RYZ2@1236|Gammaproteobacteria,1WW9H@135613|Chromatiales	135613|Chromatiales	C	PFAM Nitrate reductase gamma subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_gam
k59_766444_1	1121406.JAEX01000003_gene1641	5.92e-14	76.6	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,42TVJ@68525|delta/epsilon subdivisions,2WQ0X@28221|Deltaproteobacteria,2MGHN@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	UbiA prenyltransferase family	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_1177805_1	1134912.AJTV01000028_gene2045	7.08e-22	95.1	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,2U85S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_5039_1	713586.KB900536_gene655	5.22e-154	441.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1WVYY@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM isocitrate dehydrogenase, NADP-dependent	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,Iso_dh
k59_1236627_1	84588.SYNW0394	4.48e-38	145.0	COG0517@1|root,COG1082@1|root,COG2089@1|root,COG0517@2|Bacteria,COG1082@2|Bacteria,COG2089@2|Bacteria,1G4IG@1117|Cyanobacteria,1GZZR@1129|Synechococcus	1117|Cyanobacteria	M	acid synthetase	-	-	2.5.1.101,2.5.1.56	ko:K01654,ko:K18430	ko00520,ko01100,map00520,map01100	-	R01804,R04435,R10304	RC00159	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2,CBS,NeuB,SAF
k59_708299_1	219305.MCAG_00046	6.97e-41	149.0	COG3104@1|root,COG3104@2|Bacteria,2GKB1@201174|Actinobacteria,4D8IX@85008|Micromonosporales	201174|Actinobacteria	E	POT family	dtpT	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
k59_708299_2	1469245.JFBG01000027_gene1455	7.25e-51	169.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1WVX9@135613|Chromatiales	135613|Chromatiales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_357996_1	551789.ATVJ01000001_gene1453	9.67e-11	63.5	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,2TTUK@28211|Alphaproteobacteria,43WC9@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	COG0076 Glutamate decarboxylase and related PLP-dependent proteins	MA20_08345	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
k59_1060809_1	338963.Pcar_2866	1.01e-103	314.0	COG3303@1|root,COG3303@2|Bacteria,1MVJT@1224|Proteobacteria,42MPU@68525|delta/epsilon subdivisions,2WIJ1@28221|Deltaproteobacteria,43UNQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	nrfA	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C552
k59_649518_1	1269813.ATUL01000013_gene205	1.1e-95	302.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,1WWBM@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
k59_649518_2	1283300.ATXB01000001_gene830	2.04e-99	298.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1RQ2D@1236|Gammaproteobacteria,1XEAH@135618|Methylococcales	135618|Methylococcales	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
k59_708300_1	1541065.JRFE01000015_gene327	1.56e-26	108.0	COG0667@1|root,COG0667@2|Bacteria,1G3RI@1117|Cyanobacteria,3VMR2@52604|Pleurocapsales	1117|Cyanobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_708300_2	344747.PM8797T_22208	2.42e-23	97.4	COG0320@1|root,COG0320@2|Bacteria,2IXVE@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_886341_1	1384056.N787_10265	1.42e-75	246.0	COG0457@1|root,COG0457@2|Bacteria,1N06S@1224|Proteobacteria,1S516@1236|Gammaproteobacteria,1XCBP@135614|Xanthomonadales	135614|Xanthomonadales	S	MTH538 TIR-like domain (DUF1863)	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF1863,WD40
k59_473363_1	1240349.ANGC01000017_gene4781	1.42e-119	378.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,2GIYE@201174|Actinobacteria,4FVXQ@85025|Nocardiaceae	201174|Actinobacteria	EQ	Hydantoinase/oxoprolinase N-terminal region	oplA	-	3.5.2.14,3.5.2.9	ko:K01469,ko:K01473	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00251,R03187	RC00553,RC00632	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0266c	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_532169_1	335543.Sfum_3990	1.22e-23	95.1	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,Phage_int_SAM_1,Phage_int_SAM_3,Phage_integrase,zf-IS66
k59_179868_1	1000565.METUNv1_03805	1.51e-21	97.4	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,2KUFQ@206389|Rhodocyclales	206389|Rhodocyclales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
k59_825342_1	945713.IALB_0517	1.1e-117	349.0	COG0415@1|root,COG0415@2|Bacteria	2|Bacteria	L	Belongs to the DNA photolyase family	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_239010_2	156889.Mmc1_0042	9.11e-80	245.0	COG1876@1|root,COG1876@2|Bacteria,1RB64@1224|Proteobacteria	1224|Proteobacteria	M	peptidase M15B and M15C DD-carboxypeptidase VanY	-	-	-	-	-	-	-	-	-	-	-	-	VanY
k59_179876_2	631362.Thi970DRAFT_03296	1.67e-114	336.0	COG3267@1|root,COG3267@2|Bacteria,1REWJ@1224|Proteobacteria,1S518@1236|Gammaproteobacteria,1X0QD@135613|Chromatiales	1236|Gammaproteobacteria	U	Type II secretory pathway, component ExeA	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
k59_1412719_1	1408473.JHXO01000002_gene3944	6.55e-127	372.0	COG3507@1|root,COG3507@2|Bacteria,4NHV4@976|Bacteroidetes,2FSJ1@200643|Bacteroidia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
k59_1471319_1	1095767.CAHD01000213_gene631	7.38e-132	390.0	COG0392@1|root,COG0392@2|Bacteria,2GMAV@201174|Actinobacteria,4F0KN@85016|Cellulomonadaceae	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
k59_1001366_2	1343739.PAP_08585	7.61e-12	69.3	COG4902@1|root,arCOG03957@2157|Archaea,2XX05@28890|Euryarchaeota,243QP@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein domain (DUF2202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2202
k59_5077_1	2340.JV46_26220	2.65e-201	567.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1J4U5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iJN746.PP_0436	S4,tRNA-synt_1b
k59_414499_1	405948.SACE_4499	1.91e-65	209.0	COG0294@1|root,COG0294@2|Bacteria,2GJDQ@201174|Actinobacteria,4DYEE@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
k59_239026_1	593907.Celgi_2827	3.75e-62	206.0	COG4129@1|root,COG4129@2|Bacteria,2GIR7@201174|Actinobacteria,4F0JJ@85016|Cellulomonadaceae	201174|Actinobacteria	S	Fusaric acid resistance protein-like	-	-	-	-	-	-	-	-	-	-	-	-	FUSC_2
k59_1412740_1	404589.Anae109_0153	3.91e-35	125.0	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,42SST@68525|delta/epsilon subdivisions,2WPWN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM PTS system fructose subfamily IIA component	-	-	2.7.1.191	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1	-	-	EIIA-man
k59_1588475_1	1487953.JMKF01000078_gene4089	7.05e-40	137.0	COG0432@1|root,COG0432@2|Bacteria,1G5WN@1117|Cyanobacteria,1HB6T@1150|Oscillatoriales	1117|Cyanobacteria	S	Secondary thiamine-phosphate synthase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
k59_1297456_1	743718.Isova_2520	7.96e-17	79.3	COG0084@1|root,COG0084@2|Bacteria,2GMJJ@201174|Actinobacteria,4F3HI@85017|Promicromonosporaceae	201174|Actinobacteria	L	TatD related DNase	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
k59_1297456_2	1121914.AUDW01000030_gene1249	5.29e-06	55.1	COG3266@1|root,COG3583@1|root,COG3266@2|Bacteria,COG3583@2|Bacteria,1TVFD@1239|Firmicutes,4I2CN@91061|Bacilli,3WFIX@539002|Bacillales incertae sedis	91061|Bacilli	S	G5	-	-	-	-	-	-	-	-	-	-	-	-	G5
k59_1706259_1	857087.Metme_0981	1.7e-62	199.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1XEVR@135618|Methylococcales	135618|Methylococcales	L	Endonuclease/Exonuclease/phosphatase family	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_1706259_2	1286093.C266_15819	3.12e-25	100.0	COG0461@1|root,COG0461@2|Bacteria,1MVP7@1224|Proteobacteria,2VSR8@28216|Betaproteobacteria,1K1C7@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
k59_1529901_1	419610.Mext_3287	9.71e-44	156.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,2TSI5@28211|Alphaproteobacteria,1JTGT@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_250900_1	883.DvMF_0783	3.26e-79	250.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,42MU3@68525|delta/epsilon subdivisions,2WKTF@28221|Deltaproteobacteria,2M8YY@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
k59_1419740_1	765912.Thimo_2681	1.65e-132	393.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RR14@1236|Gammaproteobacteria,1WX2Y@135613|Chromatiales	135613|Chromatiales	I	synthetase	-	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_954335_1	344747.PM8797T_17599	1.71e-14	72.8	2CAZH@1|root,2Z7RU@2|Bacteria,2IZW6@203682|Planctomycetes	203682|Planctomycetes	C	TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	-
k59_954335_2	96561.Dole_1556	7.38e-69	224.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2WIJ5@28221|Deltaproteobacteria,2MHSR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	frdA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_17274_1	1120966.AUBU01000005_gene3796	4.06e-133	396.0	COG2936@1|root,COG2936@2|Bacteria,4NFFB@976|Bacteroidetes,47JKV@768503|Cytophagia	976|Bacteroidetes	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_1419742_2	1249627.D779_1787	5.64e-238	679.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales	135613|Chromatiales	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HTH_12,OB_RNB,RNB,S1
k59_1069888_1	375286.mma_0600	7.9e-60	204.0	COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,2VH20@28216|Betaproteobacteria,472DT@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	D-Ala-D-Ala carboxypeptidase 3 (S13) family	dacB	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
k59_1306526_1	1120949.KB903302_gene6502	2.32e-48	179.0	COG0457@1|root,COG0846@1|root,COG1672@1|root,COG0457@2|Bacteria,COG0846@2|Bacteria,COG1672@2|Bacteria,2H0S2@201174|Actinobacteria	2|Bacteria	K	SIR2-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE,SIR2_2
k59_1184776_1	384765.SIAM614_22787	7.76e-79	253.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TR1V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Dehydrogenase	-	-	1.12.1.2,1.6.5.3	ko:K00335,ko:K18005	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_1712223_1	1286106.MPL1_05679	2.11e-62	214.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,45ZWT@72273|Thiotrichales	72273|Thiotrichales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1712223_2	767434.Fraau_1170	1.12e-78	249.0	COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,1RS3S@1236|Gammaproteobacteria,1X3N9@135614|Xanthomonadales	135614|Xanthomonadales	HL	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX,NUDIX_4,TMP-TENI
k59_1712223_3	762983.HMPREF9444_00672	1.7e-12	64.3	COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,1SC7M@1236|Gammaproteobacteria,1Y4W5@135624|Aeromonadales	135624|Aeromonadales	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	yacG	-	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
k59_479797_1	671143.DAMO_3166	4.36e-50	176.0	COG0845@1|root,COG0845@2|Bacteria,2NPBH@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	macA_1	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_D23
k59_538618_1	590998.Celf_1150	1.92e-106	321.0	COG0153@1|root,COG0153@2|Bacteria,2GJXI@201174|Actinobacteria,4F1TD@85016|Cellulomonadaceae	201174|Actinobacteria	G	Belongs to the GHMP kinase family. GalK subfamily	galK	-	2.7.1.6,2.7.7.12	ko:K00849,ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955,R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
k59_832139_1	580332.Slit_0824	7.97e-174	493.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VNWB@28216|Betaproteobacteria	28216|Betaproteobacteria	E	PFAM aminotransferase class V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_186708_1	1288298.rosmuc_04063	8.54e-32	120.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,46P06@74030|Roseovarius	28211|Alphaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_186708_2	1446473.JHWH01000023_gene2917	7.08e-78	243.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,2PVYC@265|Paracoccus	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_479801_1	1484158.PSNIH1_12060	1.39e-09	58.5	COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,3VYMB@53335|Pantoea	1236|Gammaproteobacteria	S	High frequency lysogenization protein HflD homolog	hflD	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009898,GO:0016020,GO:0019897,GO:0019898,GO:0031234,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944,GO:0098552,GO:0098562	-	ko:K07153	-	-	-	-	ko00000	-	-	-	DUF489
k59_479801_2	396588.Tgr7_1844	2.39e-197	575.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WW6D@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_420974_1	882083.SacmaDRAFT_2736	2.42e-65	223.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4E0QS@85010|Pseudonocardiales	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	ctpF	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.8	ko:K01537,ko:K12953	-	-	-	-	ko00000,ko01000	3.A.3,3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_128027_1	590998.Celf_2424	4.05e-131	387.0	COG0536@1|root,COG0536@2|Bacteria,2GISB@201174|Actinobacteria,4F0KH@85016|Cellulomonadaceae	201174|Actinobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
k59_1245475_1	1220583.GOACH_04_02440	8.26e-40	142.0	COG2365@1|root,COG2365@2|Bacteria,2GK28@201174|Actinobacteria,4GAD2@85026|Gordoniaceae	201174|Actinobacteria	T	Tyrosine phosphatase family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	Y_phosphatase3
k59_538631_1	2340.JV46_16620	1.22e-40	151.0	COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,1SBMS@1236|Gammaproteobacteria,1JBHM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
k59_954388_1	497964.CfE428DRAFT_5239	1.49e-81	263.0	COG1523@1|root,COG1523@2|Bacteria,46S5N@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_1770686_1	391615.ABSJ01000024_gene268	3.01e-38	136.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,1SASJ@1236|Gammaproteobacteria,1JBWJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Smr domain	-	-	-	-	-	-	-	-	-	-	-	-	Smr
k59_1770686_2	472759.Nhal_2432	5.05e-125	362.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1WW3F@135613|Chromatiales	135613|Chromatiales	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
k59_1770686_3	454957.IA64_11300	2.85e-53	174.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1X3XJ@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_1006712_1	1123258.AQXZ01000018_gene927	1.31e-07	54.7	COG0464@1|root,COG0464@2|Bacteria,2GJWA@201174|Actinobacteria,4FYJF@85025|Nocardiaceae	201174|Actinobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_1006712_2	1123258.AQXZ01000018_gene928	5.51e-86	254.0	COG4451@1|root,COG4451@2|Bacteria,2IIFC@201174|Actinobacteria,4G0FJ@85025|Nocardiaceae	201174|Actinobacteria	C	Ribulose bisphosphate carboxylase, small chain	cbxSC	-	4.1.1.39	ko:K01602	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_small
k59_1006712_3	935866.JAER01000029_gene1452	1.25e-36	135.0	COG1850@1|root,COG1850@2|Bacteria,2HFXU@201174|Actinobacteria,4DSGZ@85009|Propionibacteriales	201174|Actinobacteria	G	Ribulose bisphosphate carboxylase large chain, catalytic domain	cbbL	-	4.1.1.39,5.3.2.5	ko:K01601,ko:K08965	ko00270,ko00630,ko00710,ko01100,ko01120,ko01200,map00270,map00630,map00710,map01100,map01120,map01200	M00034,M00165,M00166,M00532	R00024,R03140,R07393	RC00172,RC00859,RC02421	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
k59_367171_1	446471.Xcel_3314	1.81e-75	253.0	COG1403@1|root,COG1403@2|Bacteria,2HAHI@201174|Actinobacteria,4F3G4@85017|Promicromonosporaceae	201174|Actinobacteria	V	Domain of unknown function (DUF222)	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_367171_2	590998.Celf_0701	1.03e-86	284.0	COG3459@1|root,COG3459@2|Bacteria	2|Bacteria	G	carbohydrate binding	cbpA	-	2.4.1.333	ko:K21298	-	-	-	-	ko00000,ko01000	-	GH94	-	Glyco_hydro_36,Glyco_transf_36
k59_250988_1	1129794.C427_0215	3.21e-133	392.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,465QH@72275|Alteromonadaceae	1236|Gammaproteobacteria	CP	COG0651 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_1654587_1	713586.KB900536_gene1841	4.07e-98	320.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales	135613|Chromatiales	E	glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1184809_1	713586.KB900536_gene1177	6.88e-78	259.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1594510_1	1206732.BAGD01000097_gene4221	2.07e-24	105.0	COG1765@1|root,COG1765@2|Bacteria,2IIK7@201174|Actinobacteria,4G0F3@85025|Nocardiaceae	201174|Actinobacteria	O	OsmC-like protein	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	OsmC
k59_1594510_2	1122933.JNIY01000004_gene2328	4.83e-57	193.0	COG1540@1|root,COG1540@2|Bacteria,2H5Y7@201174|Actinobacteria,4F16J@85016|Cellulomonadaceae	201174|Actinobacteria	S	5-oxoprolinase (ATP-hydrolyzing) activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1594510_3	266940.Krad_4439	2.06e-104	307.0	COG0207@1|root,COG0207@2|Bacteria,2GKY0@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	GO:0003674,GO:0003824,GO:0004799,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009125,GO:0009129,GO:0009130,GO:0009131,GO:0009157,GO:0009159,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009178,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0032259,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042083,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046073,GO:0046078,GO:0046079,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
k59_1360142_1	622637.KE124774_gene2948	9.75e-99	290.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2TRRS@28211|Alphaproteobacteria,36XGX@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Aconitase C-terminal domain	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_1712247_1	1126627.BAWE01000005_gene6111	6.76e-42	164.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_420989_1	926554.KI912617_gene4801	2.14e-08	60.8	COG0465@1|root,COG0465@2|Bacteria,1WIXJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1419782_1	216596.pRL120357	1.18e-236	654.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria,4B9KD@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_29,HTH_32
k59_1712248_1	935866.JAER01000029_gene1454	6.79e-117	343.0	COG0464@1|root,COG0464@2|Bacteria,2GJWA@201174|Actinobacteria,4DT1G@85009|Propionibacteriales	201174|Actinobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_1360143_1	335543.Sfum_0150	1.71e-17	82.4	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1MWPE@1224|Proteobacteria,42P2T@68525|delta/epsilon subdivisions,2WJ9B@28221|Deltaproteobacteria,2MRDR@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	rsmB	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
k59_1360143_2	1121456.ATVA01000014_gene467	6.34e-84	261.0	COG1852@1|root,COG1852@2|Bacteria,1RAI2@1224|Proteobacteria,42QUD@68525|delta/epsilon subdivisions,2WMQ5@28221|Deltaproteobacteria,2M8MW@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function DUF116	-	-	-	ko:K09729	-	-	-	-	ko00000	-	-	-	DUF116
k59_1594522_2	493475.GARC_2375	4.78e-14	68.2	COG2841@1|root,COG2841@2|Bacteria,1N760@1224|Proteobacteria,1SCCY@1236|Gammaproteobacteria,4698E@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF465)	-	-	-	ko:K09794	-	-	-	-	ko00000	-	-	-	DUF465
k59_771802_1	1049564.TevJSym_aq00080	6.12e-15	68.6	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	tusA	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
k59_771802_2	1116472.MGMO_122c00210	1.56e-99	300.0	COG0301@1|root,COG0301@2|Bacteria,1N1R1@1224|Proteobacteria,1T212@1236|Gammaproteobacteria,1XEUN@135618|Methylococcales	135618|Methylococcales	H	Thiamine biosynthesis protein (ThiI)	-	-	-	-	-	-	-	-	-	-	-	-	ThiI
k59_128057_1	1305737.JAFX01000001_gene1250	3.73e-82	261.0	COG0405@1|root,COG0405@2|Bacteria,4NG3X@976|Bacteroidetes,47MKS@768503|Cytophagia	976|Bacteroidetes	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_303695_1	935839.JAGJ01000006_gene3427	6.75e-87	271.0	COG0138@1|root,COG0138@2|Bacteria,2GJWU@201174|Actinobacteria,4F4A6@85017|Promicromonosporaceae	201174|Actinobacteria	F	AICARFT/IMPCHase bienzyme	purH	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_1594523_1	1122185.N792_05765	1.01e-47	173.0	COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,1RQUG@1236|Gammaproteobacteria,1X59Q@135614|Xanthomonadales	135614|Xanthomonadales	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
k59_17397_1	768671.ThimaDRAFT_0558	6.41e-64	196.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,1S675@1236|Gammaproteobacteria,1WYPN@135613|Chromatiales	135613|Chromatiales	C	Iron--sulfur cluster insertion protein erpA	erpA	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
k59_17397_2	1163617.SCD_n02520	1.65e-28	110.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2VJD7@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_1712261_1	1122994.AUFR01000031_gene590	4.45e-08	55.1	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1149@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1149@2|Bacteria,2I995@201174|Actinobacteria,4DVUV@85009|Propionibacteriales	201174|Actinobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_715044_1	880072.Desac_0598	1.25e-52	179.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,42MG2@68525|delta/epsilon subdivisions,2WJ01@28221|Deltaproteobacteria,2MRC7@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Cell cycle protein	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_303697_1	1453501.JELR01000002_gene1336	1.65e-66	229.0	COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,1RNKG@1236|Gammaproteobacteria,46408@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	COG0823 Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	PD40
k59_1360155_1	1265502.KB905932_gene1929	2.16e-38	145.0	COG0491@1|root,COG0491@2|Bacteria,1MUXF@1224|Proteobacteria,2VKJX@28216|Betaproteobacteria,4AAKM@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1834816_1	1121403.AUCV01000019_gene3263	4.33e-85	266.0	COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,42NUG@68525|delta/epsilon subdivisions,2WJM4@28221|Deltaproteobacteria,2MMK6@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Urease alpha-subunit, N-terminal domain	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
k59_1306607_1	471853.Bcav_4215	1.1e-79	246.0	COG1181@1|root,COG1181@2|Bacteria,2GRWM@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_128072_1	2340.JV46_08640	5.29e-45	158.0	COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1J5XQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	transport system, permease component	ypjD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
k59_1834824_1	1097668.BYI23_A011210	1.54e-58	202.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,1K23B@119060|Burkholderiaceae	28216|Betaproteobacteria	M	penicillin-binding protein 1A	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_1245534_1	765911.Thivi_1391	2.89e-111	333.0	COG0531@1|root,COG0531@2|Bacteria,1MUA2@1224|Proteobacteria,1RNND@1236|Gammaproteobacteria,1WZVZ@135613|Chromatiales	135613|Chromatiales	E	Amino acid permease	-	-	-	ko:K03758	-	-	-	-	ko00000,ko02000	2.A.3.2	-	-	AA_permease_2
k59_1306611_1	999541.bgla_2g04530	4.19e-11	69.7	COG0583@1|root,COG0583@2|Bacteria,1R7YP@1224|Proteobacteria,2WEB8@28216|Betaproteobacteria,1K4QD@119060|Burkholderiaceae	28216|Betaproteobacteria	K	LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_17416_1	1370120.AUWR01000011_gene1092	8.32e-07	51.6	COG0604@1|root,COG0604@2|Bacteria,2GMHR@201174|Actinobacteria,235GY@1762|Mycobacteriaceae	201174|Actinobacteria	C	NADPH quinone	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1184845_1	1122603.ATVI01000001_gene1931	5.73e-107	324.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1X3IF@135614|Xanthomonadales	135614|Xanthomonadales	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	ctaC	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
k59_1770726_1	395493.BegalDRAFT_0739	8.61e-26	111.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,4604X@72273|Thiotrichales	72273|Thiotrichales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
k59_1069997_2	936589.HMPREF1521_1437	6.1e-91	275.0	COG2877@1|root,COG2877@2|Bacteria,1TR2G@1239|Firmicutes,4H20D@909932|Negativicutes	909932|Negativicutes	M	Belongs to the KdsA family	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
k59_73722_1	272560.BPSL0821	1.11e-96	290.0	COG0627@1|root,COG0627@2|Bacteria,1MUID@1224|Proteobacteria,2VJB2@28216|Betaproteobacteria,1K0PQ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Serine hydrolase involved in the detoxification of formaldehyde	fghA	-	3.1.2.12	ko:K01070	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R00527	RC00167,RC00320	ko00000,ko00001,ko01000	-	CE1	-	Esterase
k59_1480608_1	1496688.ER33_04445	1.23e-17	81.6	COG1171@1|root,COG1171@2|Bacteria,1G22X@1117|Cyanobacteria,22SGF@167375|Cyanobium	1117|Cyanobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.ilvA	PALP,Thr_dehydrat_C
k59_896682_2	1298863.AUEP01000008_gene1112	9.12e-168	479.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,4DTNE@85009|Propionibacteriales	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	oppC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_1836051_1	1249627.D779_4134	3.84e-42	153.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales	135613|Chromatiales	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_1836051_2	572477.Alvin_0804	4.5e-30	118.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1WW8D@135613|Chromatiales	135613|Chromatiales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1185831_1	316057.RPD_1532	1.6e-51	181.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,3JUZI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	MA20_01045	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N,Transketolase_C
k59_74940_2	1101190.ARWB01000001_gene2532	8.87e-09	61.6	COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,36XXN@31993|Methylocystaceae	28211|Alphaproteobacteria	C	CoA binding domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1481921_1	1249627.D779_0034	1.49e-68	217.0	COG3437@1|root,COG3437@2|Bacteria,1QUN9@1224|Proteobacteria,1S0ZZ@1236|Gammaproteobacteria,1WX12@135613|Chromatiales	135613|Chromatiales	KT	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	PAS,PAS_9,Response_reg
k59_1481921_2	1049564.TevJSym_bb00310	3.01e-57	179.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	bigR	-	-	ko:K03892,ko:K07721,ko:K22042,ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
k59_1481921_3	1198232.CYCME_2433	1.8e-18	77.8	2DDNE@1|root,2ZINX@2|Bacteria,1PAK4@1224|Proteobacteria,1STKN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1481921_4	177416.FTT_0054	2.27e-23	100.0	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,460G7@72273|Thiotrichales	72273|Thiotrichales	D	AFG1-like ATPase	zapE	-	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
k59_19225_1	396588.Tgr7_1157	3.45e-90	292.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales	135613|Chromatiales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2
k59_1481922_1	1109445.AGSX01000043_gene391	2.02e-54	181.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,1RSHS@1236|Gammaproteobacteria,1Z11B@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_0821,iECIAI1_1343.ECIAI1_0813,iECO103_1326.ECO103_0813,iECO111_1330.ECO111_0839,iECO26_1355.ECO26_0904,iECSE_1348.ECSE_0831,iECW_1372.ECW_m0833,iEKO11_1354.EKO11_3108,iEcE24377_1341.EcE24377A_0841,iSFV_1184.SFV_0761,iSSON_1240.SSON_0757,iWFL_1372.ECW_m0833,ic_1306.c0858	AAA_26
k59_1836063_1	1122604.JONR01000045_gene2500	4.09e-120	357.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,1SZK5@1236|Gammaproteobacteria,1XCD9@135614|Xanthomonadales	135614|Xanthomonadales	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N
k59_906060_2	270374.MELB17_08029	6.53e-32	124.0	COG3437@1|root,COG4191@1|root,COG3437@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RR5W@1236|Gammaproteobacteria,465JT@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Histidine kinase	fixL	-	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_9,Phosphonate-bd,Response_reg
k59_839775_1	765911.Thivi_4465	1.63e-108	324.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1WWQH@135613|Chromatiales	135613|Chromatiales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	ko:K13283	-	-	-	-	ko00000,ko02000	2.A.4.7.1	-	-	Cation_efflux,ZT_dimer
k59_839775_2	1121403.AUCV01000043_gene91	1.1e-09	59.7	28MPZ@1|root,2ZAYZ@2|Bacteria,1R6T8@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_84251_1	998674.ATTE01000001_gene3560	1.34e-61	200.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria,460HA@72273|Thiotrichales	72273|Thiotrichales	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
k59_311324_1	471853.Bcav_2349	1.99e-184	527.0	COG0504@1|root,COG0504@2|Bacteria,2GJ13@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1699	CTP_synth_N,GATase
k59_311324_2	743718.Isova_1361	9.87e-46	154.0	COG0494@1|root,COG0494@2|Bacteria,2GNW6@201174|Actinobacteria,4F4C2@85017|Promicromonosporaceae	201174|Actinobacteria	L	NUDIX domain	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_1602046_1	557598.LHK_02324	3.55e-87	275.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2VHXG@28216|Betaproteobacteria,2KPGU@206351|Neisseriales	206351|Neisseriales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_135737_1	1034769.KB910518_gene1640	2.57e-61	203.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4H9NW@91061|Bacilli,26TK1@186822|Paenibacillaceae	91061|Bacilli	L	DNA polymerase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_839780_1	768710.DesyoDRAFT_4314	9.58e-79	260.0	COG0427@1|root,COG0427@2|Bacteria	2|Bacteria	C	acetyl-CoA hydrolase activity	-	-	-	ko:K18122	ko00650,ko01100,ko01200,map00650,map01100,map01200	-	R05336	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
k59_1662393_1	105559.Nwat_0472	1.35e-21	96.7	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1WXUC@135613|Chromatiales	135613|Chromatiales	S	ABC-type transport system involved in multi-copper enzyme maturation, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_1845449_1	1435356.Y013_03350	5.37e-38	137.0	COG0829@1|root,COG0829@2|Bacteria	2|Bacteria	O	nickel cation binding	ureD	-	-	ko:K03190	-	-	-	-	ko00000	-	-	-	UreD
k59_1013057_2	745310.G432_14365	4.39e-09	64.7	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,2K061@204457|Sphingomonadales	204457|Sphingomonadales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
k59_1490376_1	118163.Ple7327_3980	1.03e-74	236.0	COG0535@1|root,COG1433@1|root,COG0535@2|Bacteria,COG1433@2|Bacteria,1G0CJ@1117|Cyanobacteria,3VHSD@52604|Pleurocapsales	1117|Cyanobacteria	C	Nitrogenase cofactor biosynthesis protein NifB	-	-	-	ko:K02585	-	-	-	-	ko00000	-	-	-	Nitro_FeMo-Co,Radical_SAM
k59_1543781_1	1049564.TevJSym_af00530	8.2e-51	179.0	28K74@1|root,2Z9VA@2|Bacteria,1R8MQ@1224|Proteobacteria,1SKKZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1490378_1	1298880.AUEV01000004_gene1915	2.57e-40	150.0	COG0277@1|root,COG0277@2|Bacteria,2GIS6@201174|Actinobacteria	201174|Actinobacteria	C	FAD linked	agpS	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_428597_1	2340.JV46_17130	2.03e-46	161.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1J4Z6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_722479_1	1236959.BAMT01000009_gene3392	7.86e-60	198.0	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2VIAA@28216|Betaproteobacteria,2KNM2@206350|Nitrosomonadales	206350|Nitrosomonadales	M	TIGRFAM type I secretion membrane fusion protein, HlyD family	-	-	-	ko:K02022	-	-	-	-	ko00000	-	-	-	HlyD,HlyD_3
k59_664015_1	331678.Cphamn1_1230	1.32e-168	482.0	COG0226@1|root,COG0226@2|Bacteria	2|Bacteria	P	phosphate ion binding	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_1192536_2	768671.ThimaDRAFT_1031	9.55e-79	248.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,1WWMP@135613|Chromatiales	135613|Chromatiales	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_839800_1	710696.Intca_3342	5.66e-33	131.0	2EZYF@1|root,33T2N@2|Bacteria,2H3P5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_487363_1	2340.JV46_15990	5.39e-39	133.0	COG0316@1|root,COG0316@2|Bacteria,1RFIX@1224|Proteobacteria,1S3SB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the HesB IscA family	-	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
k59_1082537_1	861299.J421_4065	2.67e-72	235.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	choD	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016614,GO:0016899,GO:0016995,GO:0044419,GO:0051704,GO:0055114	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,GMC_oxred_C,GMC_oxred_N
k59_312154_1	318167.Sfri_3969	4.61e-23	90.9	COG2388@1|root,COG2388@2|Bacteria,1PN9M@1224|Proteobacteria,1SDBK@1236|Gammaproteobacteria,2QCU1@267890|Shewanellaceae	1236|Gammaproteobacteria	S	GCN5-related N-acetyl-transferase	-	-	-	ko:K06975	-	-	-	-	ko00000	-	-	-	Acetyltransf_CG
k59_312154_2	686340.Metal_2785	2.29e-42	143.0	COG0662@1|root,COG0662@2|Bacteria,1N00P@1224|Proteobacteria,1S759@1236|Gammaproteobacteria,1XFIZ@135618|Methylococcales	135618|Methylococcales	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_312154_3	670307.HYPDE_33213	8.14e-50	176.0	COG3011@1|root,COG3011@2|Bacteria,1N0MB@1224|Proteobacteria	1224|Proteobacteria	S	Lipase maturation factor	-	-	-	-	-	-	-	-	-	-	-	-	DUF393,LMF1
k59_29719_1	472759.Nhal_1480	7.01e-93	279.0	COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,1RP78@1236|Gammaproteobacteria,1X09I@135613|Chromatiales	135613|Chromatiales	E	Amino acid kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_312162_1	335543.Sfum_1610	2.01e-30	120.0	COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,1MV5G@1224|Proteobacteria,42MPT@68525|delta/epsilon subdivisions,2WJG9@28221|Deltaproteobacteria,2MR96@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Uncharacterized protein conserved in bacteria (DUF2344)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
k59_1428334_1	293826.Amet_3232	2.1e-05	50.8	COG4585@1|root,COG4585@2|Bacteria,1TQI3@1239|Firmicutes,249R9@186801|Clostridia,36FHU@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K11623	ko02020,map02020	M00484	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3
k59_546719_1	224914.BMEI0786	2.18e-48	164.0	COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2U787@28211|Alphaproteobacteria,1J2IX@118882|Brucellaceae	28211|Alphaproteobacteria	M	Glycine zipper	yiaD	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,Gly-zipper_YMGG,OmpA
k59_29729_1	756067.MicvaDRAFT_2036	1.47e-06	50.4	COG0438@1|root,COG0463@1|root,COG3914@1|root,COG0438@2|Bacteria,COG0463@2|Bacteria,COG3914@2|Bacteria,1FZUY@1117|Cyanobacteria,1H8CK@1150|Oscillatoriales	1117|Cyanobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_41,Glycos_transf_1,Glycos_transf_2,Methyltransf_21,Methyltransf_23
k59_1544599_1	765912.Thimo_0086	6.75e-12	63.5	COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,1S6VJ@1236|Gammaproteobacteria,1WYAC@135613|Chromatiales	135613|Chromatiales	NU	pilus assembly protein PilP	-	-	-	ko:K02665	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilP
k59_1544599_2	765910.MARPU_16480	6.72e-21	95.9	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1WWYN@135613|Chromatiales	135613|Chromatiales	U	type IV pilus secretin PilQ	-	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_605340_2	313603.FB2170_11081	2.09e-06	47.8	arCOG08935@1|root,32Z08@2|Bacteria,4NU81@976|Bacteroidetes,1I9CR@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_488171_1	1123242.JH636435_gene2089	3.92e-70	224.0	COG2827@1|root,COG4294@1|root,COG2827@2|Bacteria,COG4294@2|Bacteria,2IY4V@203682|Planctomycetes	203682|Planctomycetes	L	UV-endonuclease UvdE	uvsE	-	-	-	-	-	-	-	-	-	-	-	GIY-YIG,UvdE
k59_1663242_1	1123373.ATXI01000001_gene538	1.39e-24	103.0	COG1030@1|root,COG1030@2|Bacteria,2GH7J@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD
k59_1663242_2	933262.AXAM01000055_gene1250	1.1e-30	115.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,42QXV@68525|delta/epsilon subdivisions,2WMXB@28221|Deltaproteobacteria,2MKAZ@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_664804_1	1205680.CAKO01000028_gene4658	4.11e-109	321.0	COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2TR0I@28211|Alphaproteobacteria,2JQCA@204441|Rhodospirillales	204441|Rhodospirillales	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
k59_546727_1	397278.JOJN01000018_gene3508	6.53e-42	151.0	COG5002@1|root,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4DP74@85009|Propionibacteriales	201174|Actinobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_1013741_1	595536.ADVE02000003_gene4077	1.04e-128	378.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1720657_1	67352.JODS01000007_gene4562	2.72e-12	68.2	COG0488@1|root,COG0488@2|Bacteria,2GJ5M@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	yjjK	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_263621_1	1385519.N801_08365	1.39e-92	275.0	COG0110@1|root,COG0110@2|Bacteria,2GNUB@201174|Actinobacteria,4FG8D@85021|Intrasporangiaceae	201174|Actinobacteria	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
k59_263621_2	1150864.MILUP08_44759	3.64e-05	45.8	COG1396@1|root,COG1396@2|Bacteria,2GJS3@201174|Actinobacteria,4DAT2@85008|Micromonosporales	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
k59_1193318_1	1211815.CBYP010000045_gene787	2.4e-29	114.0	COG0463@1|root,COG0463@2|Bacteria,2I3C0@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1193318_2	697282.Mettu_1784	2.23e-20	91.7	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RMCS@1236|Gammaproteobacteria,1XDT2@135618|Methylococcales	1236|Gammaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	wxcK	-	2.6.1.104,2.6.1.59	ko:K02805,ko:K18653	-	-	R10698	RC00006,RC00781	ko00000,ko01000,ko01007	-	-	-	DegT_DnrJ_EryC1
k59_1082580_1	866774.HMPREF9248_1182	1.78e-66	218.0	COG1190@1|root,COG1190@2|Bacteria,2GKE0@201174|Actinobacteria,4CUAX@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
k59_1013755_1	1137799.GZ78_12400	5.24e-05	48.5	COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,1RNJY@1236|Gammaproteobacteria,1XH3M@135619|Oceanospirillales	135619|Oceanospirillales	H	enzyme of heme biosynthesis	hemX	-	2.1.1.107	ko:K02496	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000	-	-	-	HemX
k59_1318359_1	717785.HYPMC_4678	4.62e-57	181.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2TRRS@28211|Alphaproteobacteria,3N6BI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_29778_1	190650.CC_1000	6.22e-37	133.0	28NZ4@1|root,2ZBW3@2|Bacteria,1RAK8@1224|Proteobacteria,2U6Q5@28211|Alphaproteobacteria,2KIDQ@204458|Caulobacterales	204458|Caulobacterales	S	SapC	-	-	-	-	-	-	-	-	-	-	-	-	SapC
k59_29778_2	225849.swp_1630	1.8e-40	150.0	COG0665@1|root,COG0665@2|Bacteria,1MU40@1224|Proteobacteria,1RMJY@1236|Gammaproteobacteria,2QAJQ@267890|Shewanellaceae	1236|Gammaproteobacteria	E	PFAM tryptophan halogenase	prnA	-	1.14.19.9	ko:K14266	ko00404,ko01130,map00404,map01130	M00789,M00790	R09570	RC00949	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_halogenase
k59_664827_1	1380391.JIAS01000012_gene4100	8.87e-144	416.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TSX8@28211|Alphaproteobacteria,2JQNE@204441|Rhodospirillales	204441|Rhodospirillales	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
k59_1491365_1	243233.MCA0114	3.16e-114	344.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,1T20U@1236|Gammaproteobacteria,1XDSA@135618|Methylococcales	135618|Methylococcales	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	-	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
k59_1013757_1	1380370.JIBA01000001_gene2218	5.4e-26	102.0	COG0463@1|root,COG0463@2|Bacteria,2GM44@201174|Actinobacteria,4FEXS@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1013757_2	367299.JOEE01000003_gene3003	4.02e-45	149.0	COG2456@1|root,COG2456@2|Bacteria,2GQTD@201174|Actinobacteria,4FH2H@85021|Intrasporangiaceae	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2304)	-	-	-	ko:K09153	-	-	-	-	ko00000	-	-	-	DUF2304
k59_1013757_3	714083.JH370377_gene1833	8.08e-12	64.3	COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria,4FMUZ@85023|Microbacteriaceae	201174|Actinobacteria	GM	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,Wzt_C
k59_1318367_1	236097.ADG881_1145	1.01e-58	190.0	COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,1RR85@1236|Gammaproteobacteria,1XH23@135619|Oceanospirillales	135619|Oceanospirillales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrC	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
k59_1318367_2	1189620.AJXL01000030_gene2807	1.35e-05	46.2	COG1347@1|root,COG1347@2|Bacteria,4NGD9@976|Bacteroidetes,1HXGP@117743|Flavobacteriia,2NUW6@237|Flavobacterium	976|Bacteroidetes	C	Rnf-Nqr subunit, membrane protein	nqrD	-	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
k59_136592_1	497964.CfE428DRAFT_2099	5.58e-60	204.0	COG0488@1|root,COG0488@2|Bacteria,46UUC@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM ABC transporter related	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_605375_1	743299.Acife_2667	5.12e-66	214.0	COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,1RQQA@1236|Gammaproteobacteria,2NDAY@225057|Acidithiobacillales	225057|Acidithiobacillales	L	PFAM Transposase, IS204 IS1001 IS1096 IS1165	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_1082618_1	740709.A10D4_04815	4.08e-79	256.0	COG1506@1|root,COG1506@2|Bacteria,1MWFI@1224|Proteobacteria,1RPJD@1236|Gammaproteobacteria,2QGKY@267893|Idiomarinaceae	1236|Gammaproteobacteria	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,Peptidase_S9
k59_1131790_1	644076.SCH4B_3030	2.47e-78	235.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2TSAM@28211|Alphaproteobacteria,4N9W9@97050|Ruegeria	28211|Alphaproteobacteria	C	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_664840_2	335543.Sfum_3896	1.83e-68	219.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,42M56@68525|delta/epsilon subdivisions,2WJ8W@28221|Deltaproteobacteria,2MQZM@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM isocitrate dehydrogenase, NADP-dependent	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_723264_1	1267005.KB911256_gene1650	4.15e-82	258.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,3N6DU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	FAD linked oxidases, C-terminal domain	MA20_42035	GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004458,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006089,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016053,GO:0016491,GO:0016614,GO:0016898,GO:0019249,GO:0019516,GO:0019752,GO:0022900,GO:0022904,GO:0030447,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046394,GO:0048037,GO:0050660,GO:0050662,GO:0051990,GO:0055114,GO:0071704,GO:0071949,GO:0072330,GO:0097159,GO:0099615,GO:1901265,GO:1901363,GO:1901576,GO:1901615,GO:1901617	1.1.2.4	ko:K00102	ko00620,map00620	-	R00197	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_546767_1	349124.Hhal_2235	7e-12	65.5	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,1WWBW@135613|Chromatiales	135613|Chromatiales	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_546767_2	1249627.D779_1505	2e-46	157.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,1WX6S@135613|Chromatiales	135613|Chromatiales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
k59_723266_1	395495.Lcho_1823	9.54e-30	122.0	COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1KJEE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF,HAMP,PAS_4,PAS_9,Response_reg
k59_1428390_1	1122139.KB907873_gene2725	6.49e-39	144.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1XI9U@135619|Oceanospirillales	135619|Oceanospirillales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceF	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1428390_2	1005048.CFU_3556	1.65e-26	107.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,473DP@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
k59_1318389_1	512565.AMIS_44900	2.15e-110	345.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,4D8NI@85008|Micromonosporales	201174|Actinobacteria	P	Sulfatase	atsB	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF1269,Sulfatase
k59_1720702_1	1111728.ATYS01000004_gene1578	9.52e-37	135.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009898,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0019843,GO:0019897,GO:0019898,GO:0022613,GO:0031234,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0036211,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044877,GO:0046777,GO:0070181,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1901564	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
k59_1720702_2	1116375.VEJY3_13255	2.6e-08	55.8	COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,1XU1R@135623|Vibrionales	135623|Vibrionales	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
k59_488216_1	748247.AZKH_4540	5.55e-10	65.5	COG2199@1|root,COG3706@2|Bacteria,1MV4X@1224|Proteobacteria,2VMRS@28216|Betaproteobacteria,2KWIV@206389|Rhodocyclales	206389|Rhodocyclales	T	diguanylate cyclase	-	-	2.7.7.65	ko:K21020	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF
k59_29811_1	1394176.AWUO01000003_gene859	4.99e-43	160.0	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4CYT7@85004|Bifidobacteriales	201174|Actinobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_1082637_1	1452718.JBOY01000001_gene567	5.79e-57	186.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_312233_1	1121405.dsmv_1017	9.97e-21	89.4	COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,42MHJ@68525|delta/epsilon subdivisions,2WM6S@28221|Deltaproteobacteria,2MJJ3@213118|Desulfobacterales	28221|Deltaproteobacteria	S	NGG1p interacting factor 3	-	-	3.5.4.16	ko:K22391	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	NIF3
k59_312233_2	1121405.dsmv_1016	1.75e-17	83.2	COG1579@1|root,COG1579@2|Bacteria,1R7GT@1224|Proteobacteria,42P3S@68525|delta/epsilon subdivisions,2WKVG@28221|Deltaproteobacteria,2MJ11@213118|Desulfobacterales	28221|Deltaproteobacteria	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
k59_391215_2	1121904.ARBP01000004_gene880	1.37e-16	78.2	COG1932@1|root,COG1932@2|Bacteria,4NE06@976|Bacteroidetes	976|Bacteroidetes	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_554073_1	998674.ATTE01000001_gene545	4.36e-62	199.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RMJU@1236|Gammaproteobacteria,463MH@72273|Thiotrichales	72273|Thiotrichales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_730465_1	749414.SBI_08487	1.42e-41	151.0	COG0545@1|root,COG0545@2|Bacteria,2GJK2@201174|Actinobacteria	201174|Actinobacteria	O	Peptidyl-prolyl cis-trans isomerase	fkbB	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
k59_730465_2	743718.Isova_1832	9.34e-17	74.3	COG0425@1|root,COG0425@2|Bacteria,2GSF4@201174|Actinobacteria,4F518@85017|Promicromonosporaceae	201174|Actinobacteria	O	Sulfurtransferase TusA	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
k59_1859138_1	555079.Toce_1487	3.27e-139	407.0	COG0031@1|root,COG0031@2|Bacteria,1UE9I@1239|Firmicutes,25J4U@186801|Clostridia,42FJP@68295|Thermoanaerobacterales	186801|Clostridia	E	beta subunit	-	-	2.3.1.263	ko:K21400	-	-	-	-	ko00000,ko01000	-	-	-	PALP
k59_391217_1	435830.HMPREF0045_00835	2.28e-109	322.0	COG1088@1|root,COG1088@2|Bacteria,2GNDU@201174|Actinobacteria,4D38F@85005|Actinomycetales	201174|Actinobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
k59_97787_1	401526.TcarDRAFT_1680	3.91e-56	187.0	COG1055@1|root,COG1055@2|Bacteria,1TRZC@1239|Firmicutes,4H2X6@909932|Negativicutes	909932|Negativicutes	P	Dicarboxylate carrier	-	-	-	-	-	-	-	-	-	-	-	-	MatC_N
k59_1091147_1	78245.Xaut_0284	4.06e-55	194.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria,3EYP2@335928|Xanthobacteraceae	28211|Alphaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
k59_847886_1	713586.KB900536_gene1647	4.26e-114	341.0	COG0438@1|root,COG0438@2|Bacteria,1MUTA@1224|Proteobacteria,1RS31@1236|Gammaproteobacteria,1WXR2@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_1091152_1	338969.Rfer_3852	4.74e-34	128.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,2VJ89@28216|Betaproteobacteria,4AFB1@80864|Comamonadaceae	28216|Betaproteobacteria	S	tRNA-splicing ligase RtcB	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_1670673_1	338969.Rfer_4053	3.08e-54	183.0	COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2VM19@28216|Betaproteobacteria,4ABT0@80864|Comamonadaceae	28216|Betaproteobacteria	E	FAD dependent oxidoreductase	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
k59_1375645_1	335543.Sfum_2525	9.03e-100	303.0	COG0568@1|root,COG0568@2|Bacteria,1MXGX@1224|Proteobacteria,42PIS@68525|delta/epsilon subdivisions,2WKSS@28221|Deltaproteobacteria,2MQYD@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_143695_1	391735.Veis_0892	6.23e-103	308.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2VK3Y@28216|Betaproteobacteria,4AGID@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM D-galactarate dehydratase Altronate hydrolase domain protein	-	-	4.4.1.24	ko:K16846	ko00270,map00270	-	R07633	RC01785	ko00000,ko00001,ko01000	-	-	-	GD_AH_C
k59_554095_1	1193181.BN10_420006	2.16e-131	380.0	COG0798@1|root,COG0798@2|Bacteria,2GJ4H@201174|Actinobacteria,4FECN@85021|Intrasporangiaceae	201174|Actinobacteria	P	COG0798 Arsenite efflux pump ACR3 and related	arsB	-	1.20.4.1	ko:K03325,ko:K03741	-	-	-	-	ko00000,ko01000,ko02000	2.A.59	-	-	SBF
k59_391255_1	757424.Hsero_2532	5.39e-10	61.6	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2VHGK@28216|Betaproteobacteria,473T5@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
k59_391255_2	765911.Thivi_4327	1.36e-90	278.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1WW77@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	-	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_1435781_1	159087.Daro_1778	8.23e-93	281.0	COG2009@1|root,2ZBTX@2|Bacteria,1RB22@1224|Proteobacteria,2VURZ@28216|Betaproteobacteria,2KYHM@206389|Rhodocyclales	206389|Rhodocyclales	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_1670687_1	1278078.G419_16403	2.02e-115	349.0	COG2015@1|root,COG2015@2|Bacteria,2GK38@201174|Actinobacteria,4FWW2@85025|Nocardiaceae	201174|Actinobacteria	Q	COG2015 Alkyl sulfatase and related hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_1728165_1	765910.MARPU_02765	3.39e-143	409.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1WW3W@135613|Chromatiales	135613|Chromatiales	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_1200699_1	930169.B5T_01411	6.75e-16	76.6	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,1XHWW@135619|Oceanospirillales	135619|Oceanospirillales	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_1200699_2	1122613.ATUP01000001_gene2020	3.13e-41	146.0	COG0627@1|root,COG0627@2|Bacteria,1QIRQ@1224|Proteobacteria,2TUU5@28211|Alphaproteobacteria,43Z22@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_1138483_2	1121468.AUBR01000012_gene2604	6.19e-20	83.2	2F79F@1|root,33ZQP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_202271_1	292459.STH2084	1.78e-70	235.0	COG3666@1|root,COG3666@2|Bacteria,1TQQ9@1239|Firmicutes,24AG9@186801|Clostridia	186801|Clostridia	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1728168_1	1386089.N865_04280	4.07e-06	47.0	COG3832@1|root,COG3832@2|Bacteria,2IHTJ@201174|Actinobacteria,4FH2E@85021|Intrasporangiaceae	201174|Actinobacteria	K	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
k59_1728168_2	367299.JOEE01000002_gene2295	1.47e-68	210.0	COG0346@1|root,COG0346@2|Bacteria,2IGUF@201174|Actinobacteria,4FGBK@85021|Intrasporangiaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_274178_1	626887.J057_14445	1.95e-71	236.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,465HK@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	COG4796 Type II secretory pathway, component HofQ	pilQ	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	-	ko:K02507,ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_1670690_2	91464.S7335_2407	4.22e-39	140.0	COG1309@1|root,COG1309@2|Bacteria,1G61G@1117|Cyanobacteria	1117|Cyanobacteria	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
k59_391269_1	1123355.JHYO01000008_gene2679	3.28e-117	352.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,36ZEK@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_97842_1	266940.Krad_1405	2.07e-11	64.3	COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria	201174|Actinobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
k59_97842_2	1380354.JIAN01000007_gene182	1.21e-93	282.0	COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria,4F0FP@85016|Cellulomonadaceae	201174|Actinobacteria	U	PFAM Peptidase S24 S26A S26B, conserved region	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_1091186_1	1194165.CAJF01000006_gene2449	4.03e-42	156.0	COG1070@1|root,COG1070@2|Bacteria,2HDA8@201174|Actinobacteria	201174|Actinobacteria	G	PFAM carbohydrate kinase	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
k59_1728177_1	765911.Thivi_0620	1.06e-118	343.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1WX43@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
k59_1785749_1	1380386.JIAW01000003_gene778	3.35e-98	297.0	COG1215@1|root,COG1215@2|Bacteria,2GJTE@201174|Actinobacteria,236WX@1762|Mycobacteriaceae	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
k59_554120_2	864051.BurJ1DRAFT_0531	3.55e-16	76.6	COG2010@1|root,COG2010@2|Bacteria,1REKI@1224|Proteobacteria	1224|Proteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_1375678_1	998674.ATTE01000001_gene2697	1.82e-65	211.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,463N3@72273|Thiotrichales	72273|Thiotrichales	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_202289_1	768671.ThimaDRAFT_0815	2.64e-80	260.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,1WXVP@135613|Chromatiales	135613|Chromatiales	P	PFAM von Willebrand factor type A	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_2
k59_612798_1	358823.DF19_15040	1.1e-25	108.0	COG0746@1|root,COG0746@2|Bacteria,2GJVE@201174|Actinobacteria	201174|Actinobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
k59_1019946_1	290318.Cvib_0572	6.38e-24	93.6	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	ko:K11312	-	-	-	-	ko00000	-	-	-	Cupin_2
k59_1019946_2	1073999.BN137_791	2.58e-05	46.6	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,1S22I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	GO:0003674,GO:0003824,GO:0004416,GO:0005488,GO:0006081,GO:0006082,GO:0006089,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009266,GO:0009408,GO:0009438,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0046872,GO:0046914,GO:0050896,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c02250	HAGH_C,Lactamase_B
k59_1435810_1	1203554.HMPREF1476_02224	0.000559	42.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2VI1K@28216|Betaproteobacteria,4PQEP@995019|Sutterellaceae	28216|Betaproteobacteria	FP	Ppx/GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_1435810_2	1349767.GJA_1583	2.2e-56	180.0	COG2062@1|root,COG2062@2|Bacteria,1RIVH@1224|Proteobacteria,2VSSQ@28216|Betaproteobacteria,4741H@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	phosphohistidine phosphatase	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
k59_391313_1	935863.AWZR01000001_gene1661	3.25e-52	186.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,1RSEQ@1236|Gammaproteobacteria,1X3DR@135614|Xanthomonadales	135614|Xanthomonadales	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
k59_1785755_1	1121396.KB893084_gene404	7.57e-41	141.0	COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,42QV6@68525|delta/epsilon subdivisions,2WMN1@28221|Deltaproteobacteria,2MK1Y@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_1785755_2	1121396.KB893084_gene405	7.36e-42	147.0	COG4177@1|root,COG4177@2|Bacteria,1MU52@1224|Proteobacteria,42RI3@68525|delta/epsilon subdivisions,2WNVC@28221|Deltaproteobacteria,2MJX3@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_41019_1	35754.JNYJ01000023_gene8280	3.14e-120	359.0	COG0025@1|root,COG0025@2|Bacteria,2I37Q@201174|Actinobacteria,4DACE@85008|Micromonosporales	201174|Actinobacteria	P	Sodium/hydrogen exchanger family	nhaP	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_41019_2	369723.Strop_2286	3.19e-46	153.0	COG0662@1|root,COG0662@2|Bacteria,2II1B@201174|Actinobacteria,4DDJ1@85008|Micromonosporales	201174|Actinobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_202299_1	1713.JOFV01000023_gene1344	6.5e-79	252.0	COG3307@1|root,COG3307@2|Bacteria,2I8W0@201174|Actinobacteria	201174|Actinobacteria	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
k59_1859260_1	1280954.HPO_13567	1.86e-54	185.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2TQXC@28211|Alphaproteobacteria,43WG5@69657|Hyphomonadaceae	28211|Alphaproteobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205,1.7.1.7	ko:K00088,ko:K00364	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R01134,R08240	RC00143,RC00457,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
k59_1265327_1	1501230.ET33_16820	1.3e-41	151.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,4HAEV@91061|Bacilli,26R06@186822|Paenibacillaceae	91061|Bacilli	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_919672_1	1122135.KB893137_gene1274	7.54e-73	228.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TTN3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	oppB	-	-	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
k59_919672_2	1124991.MU9_2307	3.69e-18	87.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,1RN57@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	ABC transporter substrate-binding protein	oppA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:1900750	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	iECABU_c1320.ECABU_c15240,iECNA114_1301.ECNA114_1414,iECSF_1327.ECSF_1224,iNRG857_1313.NRG857_06385	SBP_bac_5
k59_391331_1	661367.LLO_3128	3.03e-45	153.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,1JDNK@118969|Legionellales	118969|Legionellales	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
k59_554779_1	90813.JQMT01000001_gene323	8.96e-88	276.0	COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RP1C@1236|Gammaproteobacteria,4606M@72273|Thiotrichales	72273|Thiotrichales	E	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
k59_1091981_1	1194165.CAJF01000005_gene2291	2.63e-49	174.0	COG0265@1|root,COG0265@2|Bacteria,2IB8S@201174|Actinobacteria	201174|Actinobacteria	O	Trypsin-like peptidase domain	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_979971_1	717785.HYPMC_2989	6.14e-108	330.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2TT32@28211|Alphaproteobacteria,3N6B3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_1332191_1	1454010.JEOE01000011_gene2410	8.77e-46	162.0	COG4552@1|root,COG4552@2|Bacteria,2GNXZ@201174|Actinobacteria,4F11F@85016|Cellulomonadaceae	201174|Actinobacteria	S	Sterol carrier protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
k59_320379_1	1121405.dsmv_1862	1.91e-93	296.0	COG0438@1|root,COG0438@2|Bacteria,1QZ01@1224|Proteobacteria,43ATU@68525|delta/epsilon subdivisions,2X681@28221|Deltaproteobacteria,2MMVV@213118|Desulfobacterales	28221|Deltaproteobacteria	M	glycosyl transferase group 1	-	-	2.4.1.13	ko:K00695	ko00500,ko01100,map00500,map01100	-	R00806	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glycos_transf_1,Sucrose_synth
k59_99039_1	717785.HYPMC_3872	1.06e-76	236.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TSM8@28211|Alphaproteobacteria,3N86Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_144451_1	1049564.TevJSym_aa00900	3.21e-72	223.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria,1J66E@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle	rsmD	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
k59_1860469_1	494416.AYXN01000043_gene1589	5.01e-22	99.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,3NJ3R@468|Moraxellaceae	1236|Gammaproteobacteria	OU	signal peptide peptidase SppA	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_1139060_1	868864.Dester_0088	2.27e-10	64.7	COG2074@1|root,COG2074@2|Bacteria,2G4F4@200783|Aquificae	200783|Aquificae	G	ATP cone domain	-	-	-	ko:K05715	-	-	R02664	RC00002,RC00017	ko00000,ko01000	-	-	-	ATP-cone
k59_1139060_2	1243664.CAVL020000037_gene954	1.04e-69	228.0	COG3635@1|root,COG3635@2|Bacteria,1TQ5S@1239|Firmicutes,4HCYI@91061|Bacilli	91061|Bacilli	G	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	Metalloenzyme,PhosphMutase
k59_320381_1	713586.KB900536_gene819	4.3e-109	329.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WW29@135613|Chromatiales	135613|Chromatiales	S	PFAM Uncharacterised protein family UPF0027	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_144454_1	670307.HYPDE_28158	3.16e-88	283.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,3N7P7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	copper-translocating P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_1332202_1	1121943.KB900007_gene1942	1.38e-91	278.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1XH9U@135619|Oceanospirillales	135619|Oceanospirillales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_203012_1	351348.Maqu_1920	8.23e-24	94.4	COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,1SD1K@1236|Gammaproteobacteria,468DI@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TerB
k59_203012_2	396588.Tgr7_2924	1.84e-32	115.0	COG0776@1|root,COG0776@2|Bacteria,1RFWH@1224|Proteobacteria,1S5GE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Belongs to the bacterial histone-like protein family	VL23_14575	-	-	-	-	-	-	-	-	-	-	-	Bac_DNA_binding
k59_99052_1	765912.Thimo_2231	6.77e-123	361.0	COG0845@1|root,COG0845@2|Bacteria,1MWZ9@1224|Proteobacteria,1RM91@1236|Gammaproteobacteria,1WX23@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
k59_1332208_1	1123368.AUIS01000032_gene1387	1.85e-69	221.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,2NCPY@225057|Acidithiobacillales	225057|Acidithiobacillales	T	HD domain	-	-	-	ko:K13815	ko02020,ko02024,map02020,map02024	M00517	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HD,Response_reg
k59_1092003_2	706587.Desti_0692	1.81e-41	148.0	COG0674@1|root,COG0674@2|Bacteria,1R4K0@1224|Proteobacteria,42NQJ@68525|delta/epsilon subdivisions,2WJ0K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_1139067_1	555778.Hneap_2214	2.41e-47	167.0	COG3547@1|root,COG3547@2|Bacteria,1QYJU@1224|Proteobacteria,1RN0A@1236|Gammaproteobacteria,1WZMA@135613|Chromatiales	135613|Chromatiales	L	transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_99058_1	1137269.AZWL01000006_gene6634	2.5e-18	91.3	COG0489@1|root,COG0489@2|Bacteria,2I2TA@201174|Actinobacteria	201174|Actinobacteria	D	protein tyrosine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
k59_731311_1	1095767.CAHD01000088_gene1933	2.3e-150	454.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2GKI9@201174|Actinobacteria,4F0N4@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8
k59_496209_1	1278309.KB907100_gene2322	1.09e-203	577.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1XHXR@135619|Oceanospirillales	135619|Oceanospirillales	Q	TRAP-type mannitol chloroaromatic compound transport system, large permease component	gtrB	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_496209_2	216142.LT40_20180	5.78e-05	46.2	COG3637@1|root,COG3637@2|Bacteria,1RJJS@1224|Proteobacteria,1SET5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	ko:K12976	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	PagL
k59_392547_1	1301098.PKB_1484	8.05e-77	253.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CP	NADH ubiquinone oxidoreductase subunit 5 (Chain L) Multisubunit Na H antiporter, MnhA subunit	phaA	-	1.6.5.3	ko:K00341,ko:K05559	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,3.D.1	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
k59_1671414_1	1121937.AUHJ01000036_gene2809	7.45e-133	388.0	COG2801@1|root,COG2801@2|Bacteria,1R6TH@1224|Proteobacteria,1RRWS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,Mu-transpos_C,rve
k59_920920_1	1408424.JHYI01000011_gene1329	1.11e-61	204.0	COG3616@1|root,COG3616@2|Bacteria,1TSES@1239|Firmicutes,4HA93@91061|Bacilli,1ZQJR@1386|Bacillus	91061|Bacilli	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
k59_1500600_1	1163617.SCD_n02368	1.93e-76	245.0	COG0028@1|root,COG0028@2|Bacteria,1MWVW@1224|Proteobacteria,2VQU4@28216|Betaproteobacteria	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_275257_1	396588.Tgr7_0799	1.67e-114	343.0	COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,1WXAG@135613|Chromatiales	135613|Chromatiales	E	PFAM sodium alanine symporter	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_1860519_2	96561.Dole_0004	5.94e-41	142.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,42R1W@68525|delta/epsilon subdivisions,2WMQ4@28221|Deltaproteobacteria,2MJPN@213118|Desulfobacterales	28221|Deltaproteobacteria	G	PFAM Inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_1139079_1	1267005.KB911259_gene3854	2.51e-26	102.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	CP_0328	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_1139079_2	582899.Hden_2390	1.02e-15	72.0	2968C@1|root,2ZTID@2|Bacteria,1P7TY@1224|Proteobacteria,2UWB4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1266202_1	396588.Tgr7_1003	5.41e-125	390.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales	135613|Chromatiales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_987534_1	207559.Dde_2935	7.25e-62	204.0	COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42N47@68525|delta/epsilon subdivisions,2WIKZ@28221|Deltaproteobacteria,2M8JX@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Polysulphide reductase, NrfD	qrcD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_1096987_1	1385519.N801_12645	1.84e-78	245.0	COG3547@1|root,COG3547@2|Bacteria,2HASG@201174|Actinobacteria	201174|Actinobacteria	L	transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_48715_1	211165.AJLN01000153_gene672	1.82e-58	188.0	COG0702@1|root,COG0702@2|Bacteria,1G3PB@1117|Cyanobacteria	1117|Cyanobacteria	GM	PFAM NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
k59_400014_1	768671.ThimaDRAFT_2882	9.39e-89	267.0	COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,1S3T3@1236|Gammaproteobacteria,1WVZ9@135613|Chromatiales	135613|Chromatiales	S	subfamily IA, variant 1	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_928414_1	1499502.EV12_2836	3.37e-85	281.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1G2E2@1117|Cyanobacteria,1MMDC@1212|Prochloraceae	1117|Cyanobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	nifJ	GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iJN678.nifJ	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_500733_1	446466.Cfla_1602	2.47e-53	177.0	COG3599@1|root,COG3599@2|Bacteria,2GMSC@201174|Actinobacteria,4F0ZU@85016|Cellulomonadaceae	201174|Actinobacteria	D	DivIVA protein	wag31	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0022603,GO:0022604,GO:0030312,GO:0031647,GO:0040007,GO:0042546,GO:0044085,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050821,GO:0051128,GO:0060187,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944	-	-	-	-	-	-	-	-	-	-	DivIVA
k59_500733_2	1115803.HMPREF1129_1710	1.53e-53	179.0	COG0597@1|root,COG0597@2|Bacteria,2GKRX@201174|Actinobacteria,4D5GF@85005|Actinomycetales	201174|Actinobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
k59_500733_3	590998.Celf_1626	1.56e-162	462.0	COG0564@1|root,COG0564@2|Bacteria,2GIY1@201174|Actinobacteria,4F1PZ@85016|Cellulomonadaceae	201174|Actinobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_500733_4	1274524.BSONL12_04264	1.31e-11	66.2	COG2153@1|root,COG2153@2|Bacteria,1VA2J@1239|Firmicutes,4HKF5@91061|Bacilli,1ZH1Q@1386|Bacillus	91061|Bacilli	S	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	yjcF	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
k59_500733_5	1123507.ATVQ01000002_gene148	5.04e-19	85.9	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,1W7G6@1268|Micrococcaceae	201174|Actinobacteria	L	DNA polymerase	dnaE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_928417_1	1219045.BV98_000436	3.3e-28	114.0	COG0702@1|root,COG0702@2|Bacteria,1RCCP@1224|Proteobacteria,2TU1D@28211|Alphaproteobacteria,2K0TF@204457|Sphingomonadales	204457|Sphingomonadales	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
k59_442041_1	1280692.AUJL01000009_gene2963	1.8e-49	173.0	COG1921@1|root,COG1921@2|Bacteria,1TQT8@1239|Firmicutes,2498U@186801|Clostridia,36DPP@31979|Clostridiaceae	186801|Clostridia	J	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
k59_1676013_1	765912.Thimo_2230	2.12e-65	224.0	COG0841@1|root,COG4223@1|root,COG0841@2|Bacteria,COG4223@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW08@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_677459_1	765914.ThisiDRAFT_1937	1.42e-56	199.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1WX9H@135613|Chromatiales	135613|Chromatiales	C	pyruvate flavodoxin ferredoxin oxidoreductase	-	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_559312_1	187272.Mlg_0956	6.98e-56	197.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WXNN@135613|Chromatiales	135613|Chromatiales	F	PFAM glycosyl transferase family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_928429_1	1160137.KB907307_gene1208	1.05e-55	192.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4FYNR@85025|Nocardiaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_559313_1	1380354.JIAN01000005_gene2705	2.44e-118	371.0	COG1190@1|root,COG2898@1|root,COG1190@2|Bacteria,COG2898@2|Bacteria,2GKE0@201174|Actinobacteria,4F1Q9@85016|Cellulomonadaceae	201174|Actinobacteria	J	Uncharacterised conserved protein (DUF2156)	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DUF2156,tRNA-synt_2,tRNA-synt_2_TM,tRNA_anti-codon
k59_1024347_1	269799.Gmet_1141	3.4e-27	115.0	COG3299@1|root,COG3299@2|Bacteria,1P3E0@1224|Proteobacteria,437D2@68525|delta/epsilon subdivisions,2XA15@28221|Deltaproteobacteria,43VQR@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	homolog of phage Mu protein gp47	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_987568_1	187272.Mlg_0945	5.38e-66	211.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,1WX2E@135613|Chromatiales	135613|Chromatiales	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K00795,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_1340994_1	367299.JOEE01000002_gene2435	6.83e-109	318.0	COG0561@1|root,COG0561@2|Bacteria,2GP42@201174|Actinobacteria,4FF6B@85021|Intrasporangiaceae	201174|Actinobacteria	S	HAD family hydrolase	yidA	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
k59_1557494_1	1049564.TevJSym_ak00220	9.56e-42	143.0	COG1573@1|root,COG1573@2|Bacteria	2|Bacteria	L	deaminated base DNA N-glycosylase activity	ung	-	3.2.2.27	ko:K03648,ko:K21929	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4130,UDG
k59_107731_1	1049564.TevJSym_aa02120	9.57e-16	76.3	2E15V@1|root,32WKS@2|Bacteria,1N30I@1224|Proteobacteria,1SQXV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_107731_2	1049564.TevJSym_aa02130	5.14e-112	333.0	2B5QC@1|root,31YJX@2|Bacteria,1RIBA@1224|Proteobacteria,1SPMT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
k59_282654_1	1005048.CFU_1916	4.05e-84	263.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2VIGA@28216|Betaproteobacteria,472I2@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_1869256_1	1249627.D779_3935	1.18e-91	282.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1WXB2@135613|Chromatiales	135613|Chromatiales	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
k59_1869256_2	395494.Galf_2808	6.17e-50	167.0	COG0524@1|root,COG0524@2|Bacteria,1PDQE@1224|Proteobacteria,2VHMF@28216|Betaproteobacteria,44V4U@713636|Nitrosomonadales	28216|Betaproteobacteria	G	pfkB family carbohydrate kinase	adoK	-	2.7.1.15,2.7.1.20	ko:K00852,ko:K00856	ko00030,ko00230,ko01100,map00030,map00230,map01100	-	R00185,R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_1381691_1	1033802.SSPSH_002419	1.67e-59	199.0	COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane	lapB	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008653,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1903509	-	ko:K19804	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_19,TPR_7,TPR_8
k59_1676716_1	1230476.C207_03886	1.47e-05	51.2	COG1670@1|root,COG1670@2|Bacteria,1RD77@1224|Proteobacteria,2U851@28211|Alphaproteobacteria,3JVPR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
k59_988820_1	1469607.KK073769_gene5007	1.09e-48	165.0	COG1902@1|root,COG1902@2|Bacteria,1G2EB@1117|Cyanobacteria,1HQD7@1161|Nostocales	1117|Cyanobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN
k59_736840_2	269799.Gmet_1399	9.55e-29	104.0	COG4968@1|root,COG4968@2|Bacteria,1QXNR@1224|Proteobacteria,43C4N@68525|delta/epsilon subdivisions,2WRDZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Pfam:N_methyl_2	pilA-N	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl,Pilin_PilA
k59_325618_1	572477.Alvin_0501	1.59e-08	55.1	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales	135613|Chromatiales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_325618_2	765911.Thivi_3166	4.01e-54	175.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria,1WY8Z@135613|Chromatiales	135613|Chromatiales	S	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
k59_789956_1	1123401.JHYQ01000026_gene3257	2.64e-92	287.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,4602R@72273|Thiotrichales	72273|Thiotrichales	C	NADH-quinone oxidoreductase, chain M	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_678193_1	367299.JOEE01000003_gene2935	4.31e-179	525.0	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4FFSV@85021|Intrasporangiaceae	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_501390_1	521719.ATXQ01000008_gene945	9.7e-06	46.6	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1YDVE@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Bacterial regulatory protein, Fis family	pilR	-	-	ko:K02481,ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_501390_2	159087.Daro_1181	5.4e-08	56.6	COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,2VPAI@28216|Betaproteobacteria,2KVP3@206389|Rhodocyclales	206389|Rhodocyclales	T	Two-component sensor kinase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	2CSK_N,HATPase_c,HisKA
k59_1869285_1	272123.Anacy_4176	3.63e-08	61.6	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG2203@1|root,COG2905@1|root,COG3437@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2905@2|Bacteria,COG3437@2|Bacteria,1G09B@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k59_1024882_1	631454.N177_3894	1.05e-59	200.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2TRQ2@28211|Alphaproteobacteria,1JP3A@119043|Rhodobiaceae	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	nuoN2	-	1.6.5.3	ko:K00343,ko:K05568	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M
k59_282689_1	366602.Caul_5452	1.6e-54	188.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,2TVA2@28211|Alphaproteobacteria,2KFTU@204458|Caulobacterales	204458|Caulobacterales	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_208413_1	675817.VDA_001036	8.61e-16	75.9	COG1566@1|root,COG1566@2|Bacteria,1MWG0@1224|Proteobacteria,1RRE3@1236|Gammaproteobacteria,1Y2PS@135623|Vibrionales	135623|Vibrionales	V	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_618611_1	765910.MARPU_10625	3.1e-45	166.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales	135613|Chromatiales	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HTH_12,OB_RNB,RNB,S1
k59_1441756_1	1301098.PKB_4381	3.51e-100	305.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1S01K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_49998_1	546273.VEIDISOL_01581	2.33e-66	214.0	COG0505@1|root,COG0505@2|Bacteria,1TQ8N@1239|Firmicutes,4H28V@909932|Negativicutes	909932|Negativicutes	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_149916_1	2340.JV46_02820	5.35e-83	256.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1J4PA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006520,GO:0006553,GO:0006563,GO:0006564,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0034641,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046394,GO:0046451,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901615,GO:1901617	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iEcE24377_1341.EcE24377A_1004,iPC815.YPO1389,iYL1228.KPN_00935	Aminotran_5
k59_501404_1	555778.Hneap_0527	7.75e-49	170.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,1RMSZ@1236|Gammaproteobacteria,1X2PU@135613|Chromatiales	135613|Chromatiales	EGP	Drug resistance transporter Bcr CflA subfamily	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_1557533_1	1121405.dsmv_2832	3.99e-70	231.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,42MPH@68525|delta/epsilon subdivisions,2WJHW@28221|Deltaproteobacteria,2MHPG@213118|Desulfobacterales	28221|Deltaproteobacteria	M	N-acetylmuramoyl-L-alanine amidase	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,TPR_6
k59_1506700_1	1249627.D779_0510	1.13e-44	146.0	COG2920@1|root,COG2920@2|Bacteria,1RITK@1224|Proteobacteria,1S609@1236|Gammaproteobacteria,1WYM9@135613|Chromatiales	135613|Chromatiales	P	Part of a sulfur-relay system	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_618619_1	935839.JAGJ01000004_gene1863	2.96e-103	314.0	COG0477@1|root,COG2814@2|Bacteria,2GKMQ@201174|Actinobacteria,4F3VP@85017|Promicromonosporaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_107804_1	1193181.BN10_470006	6.21e-08	52.4	2EHXC@1|root,33BNY@2|Bacteria,2GSC6@201174|Actinobacteria,4FHR5@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF4229)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4229
k59_107804_2	367299.JOEE01000001_gene2032	1.2e-42	148.0	COG1575@1|root,COG1575@2|Bacteria,2GJBS@201174|Actinobacteria,4FF0S@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	GO:0003674,GO:0003824,GO:0004659,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_501411_1	555778.Hneap_2309	1.17e-52	185.0	COG1716@1|root,COG4962@1|root,COG1716@2|Bacteria,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,1RP9G@1236|Gammaproteobacteria,1WXRJ@135613|Chromatiales	135613|Chromatiales	U	type II secretion system protein E	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	FHA,T2SSE
k59_1615790_1	1007105.PT7_1951	8.11e-90	270.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2VNEK@28216|Betaproteobacteria,3T4DJ@506|Alcaligenaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_1272357_1	159087.Daro_1825	4.49e-15	74.7	COG3638@1|root,COG3638@2|Bacteria,1MXYA@1224|Proteobacteria,2VM4F@28216|Betaproteobacteria,2KZ2G@206389|Rhodocyclales	206389|Rhodocyclales	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system	phnC	-	3.6.3.28	ko:K02041	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	ABC_tran
k59_1272357_2	216142.LT40_06470	1.35e-20	89.7	COG3639@1|root,COG3639@2|Bacteria,1N3HU@1224|Proteobacteria	1224|Proteobacteria	P	COG3639 ABC-type phosphate phosphonate transport system permease component	phnE	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
k59_1869328_1	290317.Cpha266_1039	2.34e-14	72.4	COG0573@1|root,COG0573@2|Bacteria,1FE1M@1090|Chlorobi	1090|Chlorobi	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstC	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_1869328_2	517417.Cpar_0920	9.08e-14	77.4	COG0581@1|root,COG0581@2|Bacteria,1FE3G@1090|Chlorobi	1090|Chlorobi	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstA	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_1441770_1	1117647.M5M_09400	2e-135	403.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1J4JE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0739 Membrane proteins related to metalloendopeptidases	yebA	-	-	-	-	-	-	-	-	-	-	-	OapA,OapA_N,Peptidase_M23
k59_401326_2	13689.BV96_03955	7.24e-50	169.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TS1R@28211|Alphaproteobacteria,2JZW6@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_736887_1	56780.SYN_03218	2.83e-105	314.0	COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,42M93@68525|delta/epsilon subdivisions,2WK5I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Transposase, IS204 IS1001 IS1096 IS1165	-	-	-	ko:K07485	-	-	-	-	ko00000	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_208445_2	177437.HRM2_44270	2.32e-52	181.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4277
k59_929762_1	1035308.AQYY01000001_gene2182	9.99e-103	322.0	COG0308@1|root,COG0308@2|Bacteria,1TR43@1239|Firmicutes	1239|Firmicutes	E	Aminopeptidase	pepN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
k59_1206637_2	107636.JQNK01000009_gene3560	1.01e-55	177.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,36ZYD@31993|Methylocystaceae	28211|Alphaproteobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_1869352_1	485915.Dret_1248	7.12e-74	236.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,42MXS@68525|delta/epsilon subdivisions,2WKEK@28221|Deltaproteobacteria,2M8WD@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Seven times multi-haem cytochrome CxxCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Multi-haem_cyto
k59_1676772_1	367299.JOEE01000007_gene23	2.2e-104	308.0	COG0708@1|root,COG0708@2|Bacteria,2GKIS@201174|Actinobacteria,4FEP7@85021|Intrasporangiaceae	201174|Actinobacteria	L	exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_1206641_1	350054.Mflv_0407	1.31e-23	99.8	COG0300@1|root,COG0300@2|Bacteria,2I2R6@201174|Actinobacteria,2358U@1762|Mycobacteriaceae	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1097915_1	1227261.HMPREF0043_01149	7.34e-32	125.0	COG0370@1|root,COG0370@2|Bacteria,2GTV2@201174|Actinobacteria,4D44Z@85005|Actinomycetales	201174|Actinobacteria	P	Ferrous iron transport protein B	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoA,FeoB_C,FeoB_N,Gate
k59_988926_1	572477.Alvin_1236	4.83e-07	48.5	COG2076@1|root,COG2076@2|Bacteria,1MZ6P@1224|Proteobacteria,1S8TD@1236|Gammaproteobacteria,1WYQ8@135613|Chromatiales	135613|Chromatiales	U	PFAM small multidrug resistance protein	-	-	-	ko:K11741	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
k59_988926_3	1037409.BJ6T_21760	4.9e-35	129.0	2C2X7@1|root,31WBU@2|Bacteria,1P2EC@1224|Proteobacteria,2UV16@28211|Alphaproteobacteria,3JWR5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF4239)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4239
k59_282764_1	933262.AXAM01000036_gene2185	4.25e-49	170.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria,2MI8B@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_282764_2	933262.AXAM01000036_gene2186	8.99e-20	85.9	COG1381@1|root,COG1381@2|Bacteria,1RIBW@1224|Proteobacteria,42PUE@68525|delta/epsilon subdivisions,2WK4W@28221|Deltaproteobacteria,2MJFE@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
k59_149962_1	1049564.TevJSym_ac01210	5.38e-65	204.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1J6KR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030554,GO:0032991,GO:0036094,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071840,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_1506747_1	1502770.JQMG01000001_gene2341	8.27e-17	79.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,2VQ2F@28216|Betaproteobacteria,2KMBA@206350|Nitrosomonadales	206350|Nitrosomonadales	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
k59_1506747_2	1049564.TevJSym_ad01470	5e-74	227.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1J541@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	iEC042_1314.EC042_0998,iECNA114_1301.ECNA114_0940,iECSF_1327.ECSF_0829,iPC815.YPO1390	EPSP_synthase
k59_501447_1	479434.Sthe_1091	4.67e-166	483.0	COG0296@1|root,COG0296@2|Bacteria,2G5IR@200795|Chloroflexi,27XZS@189775|Thermomicrobia	189775|Thermomicrobia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_401376_1	1121403.AUCV01000062_gene3683	6.66e-37	126.0	2CHW3@1|root,32S6N@2|Bacteria,1N0I3@1224|Proteobacteria,42VYX@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Pathogenicity locus	mcrB	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	Cdd1
k59_442794_1	1453501.JELR01000002_gene680	1.58e-19	94.7	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,4668G@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	ycbB	GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0006508,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008236,GO:0008238,GO:0009273,GO:0009987,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0016807,GO:0017171,GO:0019538,GO:0033554,GO:0042546,GO:0043164,GO:0043170,GO:0044036,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0050896,GO:0051716,GO:0070004,GO:0070008,GO:0070011,GO:0071554,GO:0071704,GO:0071840,GO:0071972,GO:0140096,GO:1901564	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_1341149_1	40571.JOEA01000005_gene4095	5.19e-15	73.6	COG0572@1|root,COG0572@2|Bacteria,2GMCP@201174|Actinobacteria,4E35R@85010|Pseudonocardiales	201174|Actinobacteria	F	uridine kinase	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
k59_929812_1	479434.Sthe_3373	6.52e-37	142.0	COG0654@1|root,COG0654@2|Bacteria,2G66I@200795|Chloroflexi	200795|Chloroflexi	C	PFAM monooxygenase FAD-binding	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_1097940_1	1124983.PFLCHA0_c58510	4.7e-42	149.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,1RVNC@1236|Gammaproteobacteria,1YPV8@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_567264_1	768671.ThimaDRAFT_1025	4.35e-144	415.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1WWYB@135613|Chromatiales	135613|Chromatiales	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_567264_2	1122951.ATUE01000008_gene62	4.24e-39	142.0	COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria,3NT6F@468|Moraxellaceae	1236|Gammaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0042802,GO:0043093,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
k59_1564638_2	397291.C804_06552	3.05e-10	65.5	2DMKC@1|root,32S64@2|Bacteria,1V4QQ@1239|Firmicutes,24J3F@186801|Clostridia,27R84@186928|unclassified Lachnospiraceae	186801|Clostridia	S	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_3
k59_1514415_1	1499683.CCFF01000014_gene4032	6.12e-59	190.0	COG1272@1|root,COG1272@2|Bacteria,1TSFK@1239|Firmicutes,24CPT@186801|Clostridia,36ICC@31979|Clostridiaceae	186801|Clostridia	S	hemolysin III	hlyIII	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
k59_333183_1	1380354.JIAN01000005_gene1371	5.77e-104	316.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2GM09@201174|Actinobacteria,4F12B@85016|Cellulomonadaceae	201174|Actinobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_1448696_1	485915.Dret_2319	4.87e-05	50.8	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MAH4@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_1683698_1	582899.Hden_1820	5.3e-93	291.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2TS6C@28211|Alphaproteobacteria,3N677@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_685519_1	742159.HMPREF0004_2459	9.14e-79	251.0	COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2VJGS@28216|Betaproteobacteria,3T2DB@506|Alcaligenaceae	28216|Betaproteobacteria	U	the major facilitator superfamily	emrB	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
k59_1683699_1	857087.Metme_1457	1.64e-26	116.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_4,Response_reg
k59_1797214_1	56780.SYN_01947	3.95e-56	189.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,2MQ88@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657,ko:K13503	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_215551_1	335543.Sfum_1977	1.39e-83	273.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MQTI@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
k59_292462_1	1049564.TevJSym_aa01430	6.14e-46	157.0	2C7AT@1|root,338A4@2|Bacteria,1NF74@1224|Proteobacteria,1SRBB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_795714_2	1122134.KB893650_gene781	3.03e-58	197.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1XHWC@135619|Oceanospirillales	135619|Oceanospirillales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_292476_1	2340.JV46_26960	6.71e-121	373.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1J4E5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Cation transporter/ATPase, N-terminus	ctpF	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_450064_1	670307.HYPDE_41473	1.28e-82	269.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria,3N6KE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_1105867_1	864051.BurJ1DRAFT_3953	1.77e-70	228.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VIYF@28216|Betaproteobacteria,1KK87@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Carboxyl transferase domain	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1683725_1	467661.RKLH11_5	1.08e-109	328.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria,3ZG7V@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	lpd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1388907_1	1304275.C41B8_11233	1.41e-24	106.0	COG1249@1|root,COG1249@2|Bacteria,1MVVE@1224|Proteobacteria,1RMJT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation	sthA	GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019725,GO:0022857,GO:0022890,GO:0034220,GO:0036094,GO:0042592,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0065007,GO:0065008,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363,GO:1902600	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	iECED1_1282.ECED1_4669,iECs_1301.ECs4891,iZ_1308.Z5521	Pyr_redox_2,Pyr_redox_dim
k59_1150093_1	1442599.JAAN01000014_gene3425	1.39e-126	375.0	COG0286@1|root,COG0286@2|Bacteria,1MXPV@1224|Proteobacteria,1RXYG@1236|Gammaproteobacteria,1XC8P@135614|Xanthomonadales	135614|Xanthomonadales	V	N-6 DNA Methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
k59_567323_1	1172188.KB911820_gene2710	9.1e-119	361.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria,4FFSY@85021|Intrasporangiaceae	201174|Actinobacteria	G	Fibronectin type III-like domain	bgl2	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_1388914_1	1304865.JAGF01000001_gene318	8.02e-91	283.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4F1U8@85016|Cellulomonadaceae	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1564695_1	1123065.ATWL01000001_gene142	7.93e-128	374.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfp	-	2.7.1.90	ko:K00895	ko00010,ko00030,ko00051,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map01100,map01110,map01120,map01130	-	R00764,R02073	RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_1105914_1	999547.KI421500_gene3582	4.18e-127	369.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,2TT31@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	lysine 2,3-aminomutase	-	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_14,LAM_C,Radical_SAM
k59_744277_1	561175.KB894093_gene3155	1.16e-38	140.0	COG0026@1|root,COG0026@2|Bacteria,2GJCU@201174|Actinobacteria,4EGH2@85012|Streptosporangiales	201174|Actinobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
k59_744277_2	1304865.JAGF01000001_gene2567	4.86e-48	158.0	COG0041@1|root,COG0041@2|Bacteria,2IFFD@201174|Actinobacteria,4F154@85016|Cellulomonadaceae	201174|Actinobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	GO:0008150,GO:0040007	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3275c	AIRC
k59_1564699_1	643648.Slip_1786	5.51e-27	111.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,42JJQ@68298|Syntrophomonadaceae	186801|Clostridia	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	ACPS,Carb_kinase,YjeF_N
k59_292549_1	2340.JV46_13150	3.36e-177	511.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,1J4RJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_1150116_1	471853.Bcav_1744	8.9e-125	373.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria	201174|Actinobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_157370_1	768671.ThimaDRAFT_1036	6.42e-33	121.0	COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,1RNPD@1236|Gammaproteobacteria,1WWH6@135613|Chromatiales	135613|Chromatiales	D	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity	zapD	-	-	ko:K18778	-	-	-	-	ko00000,ko03036	-	-	-	ZapD
k59_157370_2	572477.Alvin_0150	1.61e-25	95.9	COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,1SC7M@1236|Gammaproteobacteria,1WZTU@135613|Chromatiales	135613|Chromatiales	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	yacG	-	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
k59_157370_3	572477.Alvin_0145	2.56e-32	120.0	COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,1RS3S@1236|Gammaproteobacteria,1WW2I@135613|Chromatiales	135613|Chromatiales	HL	Thiamine monophosphate synthase	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX,NUDIX_4,TMP-TENI
k59_626064_1	1123393.KB891316_gene1941	4.9e-15	74.3	COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,2VKSW@28216|Betaproteobacteria,1KSQ3@119069|Hydrogenophilales	119069|Hydrogenophilales	M	TonB C terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
k59_626064_2	1288494.EBAPG3_27980	3.04e-16	76.6	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2VJQA@28216|Betaproteobacteria,372DD@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	algH	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_215608_1	1380354.JIAN01000006_gene1112	3.19e-26	107.0	COG5164@1|root,COG5164@2|Bacteria,2I2IU@201174|Actinobacteria,4F1NB@85016|Cellulomonadaceae	201174|Actinobacteria	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	GPDPase_memb
k59_215608_2	979556.MTES_0531	2.65e-17	84.0	2CT9V@1|root,32SSX@2|Bacteria,2GKR6@201174|Actinobacteria,4FPBM@85023|Microbacteriaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4129)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
k59_1683775_1	1217718.ALOU01000009_gene1055	2.93e-37	135.0	COG0697@1|root,COG0697@2|Bacteria,1MXJ6@1224|Proteobacteria,2VIA7@28216|Betaproteobacteria,1K5U4@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1797273_2	105559.Nwat_2902	1.44e-86	273.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1WXKA@135613|Chromatiales	135613|Chromatiales	G	PFAM Alpha amylase, catalytic	-	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_215611_2	745014.OMB55_00000760	2.28e-09	62.4	2EDVS@1|root,337QX@2|Bacteria,1NEZW@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_685587_1	401053.AciPR4_0660	3.4e-55	194.0	COG1201@1|root,COG1201@2|Bacteria,3Y3XA@57723|Acidobacteria,2JHMF@204432|Acidobacteriia	204432|Acidobacteriia	L	DEAD DEAH box	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
k59_450126_2	1122179.KB890416_gene2624	2.57e-14	72.8	COG2265@1|root,COG2265@2|Bacteria,4NFP1@976|Bacteroidetes,1IQPD@117747|Sphingobacteriia	976|Bacteroidetes	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_1514532_2	1049564.TevJSym_ag01020	3.13e-23	98.6	29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,1SBT1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4390)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4390
k59_795773_1	1267535.KB906767_gene733	1.62e-71	234.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,3Y3TK@57723|Acidobacteria	57723|Acidobacteria	KOT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3,Response_reg
k59_1564724_1	545276.KB898728_gene58	2.73e-110	329.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1WW7C@135613|Chromatiales	135613|Chromatiales	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
k59_1622930_1	765912.Thimo_0188	6.95e-45	156.0	COG1043@1|root,COG1043@2|Bacteria,1QKYH@1224|Proteobacteria,1S0N9@1236|Gammaproteobacteria,1WXE9@135613|Chromatiales	135613|Chromatiales	I	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
k59_1280349_1	572477.Alvin_3001	1.24e-73	235.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1WX2U@135613|Chromatiales	135613|Chromatiales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_1213594_1	243233.MCA1981	7.34e-54	184.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,1XDNN@135618|Methylococcales	135618|Methylococcales	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
k59_567394_1	1217705.F900_00139	4.67e-21	100.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,1RMSZ@1236|Gammaproteobacteria,3NJ83@468|Moraxellaceae	1236|Gammaproteobacteria	EGP	Sugar (and other) transporter	ydgK	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_292625_1	1179773.BN6_41840	7.37e-100	301.0	COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria,4DXE3@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_685616_1	1380391.JIAS01000014_gene2361	4.25e-08	56.6	COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,2U9N6@28211|Alphaproteobacteria,2JSQS@204441|Rhodospirillales	204441|Rhodospirillales	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_685616_2	243233.MCA1632	1.33e-52	185.0	COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1XE6E@135618|Methylococcales	135618|Methylococcales	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_686903_1	1267005.KB911260_gene3576	3.96e-38	132.0	COG5349@1|root,COG5349@2|Bacteria,1MZDD@1224|Proteobacteria,2UCM4@28211|Alphaproteobacteria,3N74I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
k59_686903_2	1267005.KB911260_gene3577	8.08e-72	237.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2TRC1@28211|Alphaproteobacteria,3N6K7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	RNB,S1
k59_1516075_1	105559.Nwat_1275	1.2e-70	221.0	COG0483@1|root,COG0483@2|Bacteria,1NFR1@1224|Proteobacteria,1S31N@1236|Gammaproteobacteria,1WXP2@135613|Chromatiales	135613|Chromatiales	G	PFAM Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_1516075_2	326297.Sama_2379	5.4e-10	61.2	COG1639@1|root,COG2203@1|root,COG1639@2|Bacteria,COG2203@2|Bacteria,1NJC4@1224|Proteobacteria,1RQ9J@1236|Gammaproteobacteria,2QB1K@267890|Shewanellaceae	1236|Gammaproteobacteria	T	Signal transduction protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_3,HDOD,Pkinase
k59_451587_2	880072.Desac_0705	1.14e-55	177.0	COG0745@1|root,COG0745@2|Bacteria,1MZI2@1224|Proteobacteria,42TWU@68525|delta/epsilon subdivisions,2WQ3Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_451587_3	1378168.N510_00766	0.000186	43.1	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria	2|Bacteria	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HDOD,HisKA,Response_reg,dCache_1
k59_1624262_1	990285.RGCCGE502_14495	3e-23	101.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,4B9S1@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	MA20_39335	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_510314_1	1312954.KI914868_gene136	2.31e-18	79.7	COG1846@1|root,COG1846@2|Bacteria,2GMV1@201174|Actinobacteria,1W962@1268|Micrococcaceae	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
k59_510314_2	334390.LAF_1450	5e-26	102.0	COG2085@1|root,COG2085@2|Bacteria,1V35D@1239|Firmicutes,4HFSW@91061|Bacilli,3F5EP@33958|Lactobacillaceae	91061|Bacilli	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
k59_451591_2	1244869.H261_15657	2.52e-09	58.2	COG1669@1|root,COG1669@2|Bacteria,1MZSR@1224|Proteobacteria,2UCA9@28211|Alphaproteobacteria,2JTDJ@204441|Rhodospirillales	204441|Rhodospirillales	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
k59_158693_1	1122130.AUHN01000006_gene2131	2.62e-26	108.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2GMFD@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_158693_3	446466.Cfla_1640	8.19e-118	347.0	COG0604@1|root,COG0604@2|Bacteria,2GKHW@201174|Actinobacteria,4F0V7@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	qorA	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1624268_1	446466.Cfla_1371	8.86e-49	176.0	COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,4F12Z@85016|Cellulomonadaceae	201174|Actinobacteria	E	PFAM Peptidase M1 membrane alanine aminopeptidase	pepN	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
k59_686916_1	367299.JOEE01000008_gene586	4.75e-88	264.0	COG2185@1|root,COG2185@2|Bacteria,2HF50@201174|Actinobacteria,4FFS0@85021|Intrasporangiaceae	201174|Actinobacteria	I	Lysine 5,6-aminomutase subunit beta	kamE	-	5.4.3.3	ko:K18011	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	B12-binding,OAM_dimer
k59_686916_2	367299.JOEE01000008_gene585	1.2e-30	110.0	COG1607@1|root,COG1607@2|Bacteria,2IKM2@201174|Actinobacteria,4FGJW@85021|Intrasporangiaceae	201174|Actinobacteria	I	3-aminobutyryl-CoA ammonia lyase	-	-	4.3.1.14	ko:K18014	ko00310,map00310	-	R03030	RC00833	ko00000,ko00001,ko01000	-	-	-	4HBT
k59_745628_1	765912.Thimo_1577	4.93e-80	244.0	COG1132@1|root,COG1132@2|Bacteria,1MX5V@1224|Proteobacteria,1RY02@1236|Gammaproteobacteria,1WXG2@135613|Chromatiales	135613|Chromatiales	V	(ABC) transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1798482_1	398767.Glov_0875	1.63e-65	213.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2WIYU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Ion transport 2 domain protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
k59_1151370_1	1049564.TevJSym_bb00130	7.77e-59	203.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1J4BX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	penicillin-binding protein	mrcA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_1685369_1	1123400.KB904770_gene2728	1.77e-06	57.0	COG3317@1|root,COG3317@2|Bacteria	2|Bacteria	M	Gram-negative-bacterium-type cell outer membrane assembly	-	-	-	ko:K07287	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	Lipoprotein_18,SASA
k59_1743171_1	1049564.TevJSym_ae00550	9.08e-72	242.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1J50T@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	czcA	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
k59_1034447_1	471853.Bcav_3490	5.55e-33	118.0	2ERJ1@1|root,33J4I@2|Bacteria	2|Bacteria	S	TIGRFAM lycopene cyclase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1034447_2	1713.JOFV01000006_gene2576	8.75e-20	84.0	COG0382@1|root,3334T@2|Bacteria,2GU6R@201174|Actinobacteria,4F1I5@85016|Cellulomonadaceae	201174|Actinobacteria	H	lycopene cyclase domain	crtYf	-	-	-	-	-	-	-	-	-	-	-	-
k59_1566094_1	177437.HRM2_28140	8.66e-120	348.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,42MNQ@68525|delta/epsilon subdivisions,2WJJW@28221|Deltaproteobacteria,2MI7B@213118|Desulfobacterales	28221|Deltaproteobacteria	J	PFAM glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_2942	tRNA-synt_2e
k59_1034452_2	1033802.SSPSH_000638	3.17e-22	96.7	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	FP	Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the stringent response , an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_1151378_1	1049564.TevJSym_ao00360	1.86e-71	226.0	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,1RQ1Q@1236|Gammaproteobacteria,1J50Q@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	related to Ser Thr protein kinases	-	GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
k59_1151378_2	1049564.TevJSym_ao00280	1.93e-20	90.5	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1224|Proteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_686938_1	67373.JOBF01000002_gene1208	1.09e-58	193.0	COG0309@1|root,COG0309@2|Bacteria,2GJ7N@201174|Actinobacteria	201174|Actinobacteria	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
k59_1809582_1	626887.J057_21115	7.29e-81	249.0	COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,1RP78@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the carbamate kinase family	arcC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	iE2348C_1286.E2348C_0454,iECED1_1282.ECED1_0540,iECUMN_1333.ECUMN_0561,iEcE24377_1341.EcE24377A_0559,iG2583_1286.G2583_0641,iJN746.PP_0999	AA_kinase
k59_699133_1	768671.ThimaDRAFT_1056	4.53e-07	52.8	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,1WW5P@135613|Chromatiales	135613|Chromatiales	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
k59_699133_2	360107.CHAB381_0225	8.03e-22	94.0	COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,42PPZ@68525|delta/epsilon subdivisions,2YNHC@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Bacterial protein of unknown function (DUF839)	-	-	-	ko:K07093	-	-	-	-	ko00000	-	-	-	DUF839
k59_1580626_2	713586.KB900536_gene1705	1.32e-99	297.0	COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,1RQ7W@1236|Gammaproteobacteria,1X286@135613|Chromatiales	135613|Chromatiales	C	Oxidoreductase FAD-binding domain	-	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind
k59_1463183_1	666685.R2APBS1_0632	6.54e-59	196.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RXCB@1236|Gammaproteobacteria,1X4WJ@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the AB hydrolase superfamily. MetX family	metXS	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_1463183_2	1234364.AMSF01000095_gene2616	6.51e-07	50.4	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1X4AH@135614|Xanthomonadales	135614|Xanthomonadales	E	cystathionine	metB	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1162748_1	933262.AXAM01000015_gene101	1.69e-100	307.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42MZJ@68525|delta/epsilon subdivisions,2WJK1@28221|Deltaproteobacteria,2MIBC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_1228916_1	272630.MexAM1_META1p1137	7.97e-63	196.0	COG2010@1|root,COG2010@2|Bacteria,1RH1S@1224|Proteobacteria,2U0TD@28211|Alphaproteobacteria,1JUA5@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_1162750_1	1245471.PCA10_10350	7.83e-10	58.9	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1YCTG@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	Q	ATPases associated with a variety of cellular activities	mlaF	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0008144,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_521242_1	485915.Dret_0928	1.33e-22	90.1	COG3436@1|root,COG3436@2|Bacteria,1MYCD@1224|Proteobacteria,42TEE@68525|delta/epsilon subdivisions,2WPUG@28221|Deltaproteobacteria,2MCDC@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM IS66 Orf2 family protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k59_521242_2	879212.DespoDRAFT_03172	1.16e-65	218.0	COG4974@1|root,COG4974@2|Bacteria,1NY1A@1224|Proteobacteria,42NX3@68525|delta/epsilon subdivisions,2WME4@28221|Deltaproteobacteria,2MPJH@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_1464531_1	1267005.KB911257_gene905	9.64e-93	282.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2TSF7@28211|Alphaproteobacteria,3N66A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360,GO:1901564	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_760813_2	987059.RBXJA2T_08995	1.2e-24	98.2	COG0242@1|root,COG0242@2|Bacteria,1R9XK@1224|Proteobacteria,2VQ0U@28216|Betaproteobacteria,1KKMP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def2	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_1052813_1	767434.Fraau_1068	1.63e-21	92.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,1X34P@135614|Xanthomonadales	135614|Xanthomonadales	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
k59_1052813_2	870187.Thini_0628	1.09e-32	121.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria,460MV@72273|Thiotrichales	72273|Thiotrichales	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
k59_1230625_1	1144275.COCOR_03295	1.81e-06	48.5	COG0464@1|root,COG0464@2|Bacteria,1NF48@1224|Proteobacteria,43BJ4@68525|delta/epsilon subdivisions,2WMCV@28221|Deltaproteobacteria,2YXIN@29|Myxococcales	28221|Deltaproteobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_581590_1	620914.JH621266_gene1941	5.93e-48	172.0	COG1770@1|root,COG1770@2|Bacteria,4NF0W@976|Bacteroidetes,1HYYK@117743|Flavobacteriia,2YHA1@290174|Aquimarina	976|Bacteroidetes	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_464794_1	519989.ECTPHS_01614	3.16e-36	138.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1WVXZ@135613|Chromatiales	135613|Chromatiales	MU	type I secretion outer membrane protein, TolC	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
k59_1052832_1	710696.Intca_3593	1.19e-22	90.5	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,4FGP8@85021|Intrasporangiaceae	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
k59_1052832_2	1341646.CBMO010000033_gene5288	4.81e-33	125.0	COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,237CI@1762|Mycobacteriaceae	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_173823_1	367299.JOEE01000005_gene3587	1.41e-89	283.0	COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria,4FF5M@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the transketolase family	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_464808_1	313596.RB2501_09110	3e-26	110.0	COG2382@1|root,COG2382@2|Bacteria,4NFVV@976|Bacteroidetes,1HYKF@117743|Flavobacteriia	976|Bacteroidetes	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	AMPK1_CBM,CBM_48,Esterase
k59_1464566_1	667014.Thein_0359	2.92e-27	112.0	COG0209@1|root,COG1372@1|root,COG1594@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,COG1594@2|Bacteria,2GH8M@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Ribonucleotide reductase, all-alpha domain	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
k59_700771_1	1304865.JAGF01000001_gene1607	4.32e-99	311.0	COG1080@1|root,COG1080@2|Bacteria,2GIZZ@201174|Actinobacteria	201174|Actinobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.1.202,2.7.3.9	ko:K02768,ko:K08483,ko:K11183	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PPDK_N,PTS-HPr,PTS_EIIA_1
k59_173853_1	1304876.AZVC01000001_gene1449	1.39e-38	135.0	2BEH9@1|root,3288K@2|Bacteria,2HE0Q@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_521294_1	1163617.SCD_n02434	1.75e-137	438.0	COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria	28216|Betaproteobacteria	G	4-alpha-glucanotransferase	treY	-	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Alpha-amylase,Glyco_hydro_77
k59_348944_1	517418.Ctha_2272	5.23e-169	499.0	COG0793@1|root,COG0793@2|Bacteria,1FDSF@1090|Chlorobi	1090|Chlorobi	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF3340,PDZ,Peptidase_S41
k59_879217_1	519989.ECTPHS_08558	4.79e-119	375.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon
k59_879217_2	317025.Tcr_1937	4.93e-22	107.0	COG0715@1|root,COG0834@1|root,COG2199@1|root,COG0715@2|Bacteria,COG0834@2|Bacteria,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,1RZ41@1236|Gammaproteobacteria,462HX@72273|Thiotrichales	72273|Thiotrichales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,NMT1,SBP_bac_3
k59_1811152_1	105559.Nwat_0283	5.36e-61	202.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1WXEF@135613|Chromatiales	135613|Chromatiales	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_173861_1	1033802.SSPSH_000282	2.46e-101	320.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_640565_1	335543.Sfum_1385	4.33e-51	166.0	2DUTK@1|root,32UXS@2|Bacteria,1N1IZ@1224|Proteobacteria,42TJU@68525|delta/epsilon subdivisions,2WQQ7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1164972_1	1122931.AUAE01000013_gene2059	6.36e-07	57.0	COG0642@1|root,COG2205@2|Bacteria,4NK69@976|Bacteroidetes,2FN6H@200643|Bacteroidia	976|Bacteroidetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HisKA,PAS_4
k59_1756332_2	472759.Nhal_3094	9.14e-79	248.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,1RMKB@1236|Gammaproteobacteria,1WWEE@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
k59_1811166_1	768066.HELO_3871	2.91e-42	154.0	COG2925@1|root,COG2925@2|Bacteria,1MV0U@1224|Proteobacteria,1RM85@1236|Gammaproteobacteria,1XHYI@135619|Oceanospirillales	135619|Oceanospirillales	L	Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates	sbcB	-	3.1.11.1	ko:K01141	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_X-T_C,RNase_T
k59_1052928_1	1123393.KB891316_gene1650	0.000217	42.7	COG2920@1|root,COG2920@2|Bacteria,1NDX4@1224|Proteobacteria,2WC86@28216|Betaproteobacteria,1KT86@119069|Hydrogenophilales	119069|Hydrogenophilales	P	DsrC like protein	-	-	-	-	-	-	-	-	-	-	-	-	DsrC
k59_1052928_2	522306.CAP2UW1_2282	3.26e-17	81.6	COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,2VIZ8@28216|Betaproteobacteria	28216|Betaproteobacteria	S	beta-lactamase	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
k59_700804_1	414684.RC1_2405	4.77e-75	232.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,2TRPN@28211|Alphaproteobacteria,2JQN4@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_760911_1	765913.ThidrDRAFT_1881	9.63e-29	114.0	COG2304@1|root,COG2304@2|Bacteria,1N2UU@1224|Proteobacteria,1RXGJ@1236|Gammaproteobacteria,1WX7E@135613|Chromatiales	135613|Chromatiales	S	von Willebrand factor, type A	-	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	VWA_2
k59_760911_2	768671.ThimaDRAFT_1459	2.34e-67	211.0	2CFV2@1|root,32UMX@2|Bacteria,1N3YD@1224|Proteobacteria,1SABG@1236|Gammaproteobacteria,1WZ2C@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_760911_3	768671.ThimaDRAFT_1460	2.8e-30	114.0	COG1842@1|root,COG1842@2|Bacteria,1QGS4@1224|Proteobacteria,1TE7H@1236|Gammaproteobacteria,1WZ7S@135613|Chromatiales	135613|Chromatiales	KT	PFAM PspA IM30	-	-	-	-	-	-	-	-	-	-	-	-	PspA_IM30
k59_1464622_1	883078.HMPREF9695_02679	7.25e-51	173.0	COG2271@1|root,COG2271@2|Bacteria,1NJTU@1224|Proteobacteria,2TUBJ@28211|Alphaproteobacteria,3JU19@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	MA20_01130	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1230718_1	1304865.JAGF01000001_gene390	2.49e-08	57.0	COG1112@1|root,COG1112@2|Bacteria,2GKJW@201174|Actinobacteria,4F0UY@85016|Cellulomonadaceae	201174|Actinobacteria	L	Superfamily I DNA and RNA helicases and helicase subunits	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DUF4011
k59_348988_1	765914.ThisiDRAFT_2159	3.32e-183	523.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales	135613|Chromatiales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_640601_1	1304872.JAGC01000003_gene3687	3.02e-08	56.6	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,42NBU@68525|delta/epsilon subdivisions,2WJX9@28221|Deltaproteobacteria,2MA96@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Glycosyl transferase, family 20	otsAB	-	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,S6PP,Trehalose_PPase
k59_464913_2	935866.JAER01000003_gene1297	6.12e-27	104.0	COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria,4DRE5@85009|Propionibacteriales	201174|Actinobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
k59_231743_1	1042375.AFPL01000043_gene1393	1.61e-11	64.3	COG0594@1|root,COG0594@2|Bacteria,1MZQE@1224|Proteobacteria,1S90M@1236|Gammaproteobacteria,468AM@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031974,GO:0031981,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
k59_231743_2	421052.F945_00048	2.56e-30	109.0	COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,1SCG6@1236|Gammaproteobacteria,3NNHN@468|Moraxellaceae	1236|Gammaproteobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
k59_1464641_1	748247.AZKH_2043	6.11e-35	128.0	COG3907@1|root,COG3907@2|Bacteria,1QV68@1224|Proteobacteria,2VV12@28216|Betaproteobacteria,2KWXC@206389|Rhodocyclales	206389|Rhodocyclales	S	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
k59_464926_1	228410.NE2396	9.43e-65	210.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,2WBWD@28216|Betaproteobacteria,373ZW@32003|Nitrosomonadales	28216|Betaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrB	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
k59_231751_1	1247963.JPHU01000013_gene643	1.32e-82	251.0	COG1024@1|root,COG1024@2|Bacteria,1NDT7@1224|Proteobacteria,2U2R9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_1811218_1	472759.Nhal_0339	2.26e-148	427.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1WWFJ@135613|Chromatiales	135613|Chromatiales	M	Arabinose 5-phosphate isomerase	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
k59_1464648_2	1245471.PCA10_03470	6.74e-29	117.0	COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1YEZ2@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Signal transducing histidine kinase, homodimeric domain	chpA	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_349029_1	95619.PM1_0210650	1.27e-39	145.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RMKV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Amino Acid	puuP	-	-	-	-	-	-	-	-	-	-	-	AA_permease,AA_permease_2
k59_521399_1	269796.Rru_A2041	2.91e-64	211.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,2JPGU@204441|Rhodospirillales	204441|Rhodospirillales	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.96	ko:K16871	ko00250,ko00650,ko01100,ko01120,map00250,map00650,map01100,map01120	M00027	R10178	RC00008,RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_3
k59_1405483_1	1449976.KALB_483	2.16e-81	258.0	COG1820@1|root,COG1820@2|Bacteria,2GK1E@201174|Actinobacteria,4E0PH@85010|Pseudonocardiales	201174|Actinobacteria	G	Amidohydrolase family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_464960_1	1430440.MGMSRv2_3789	3.68e-48	167.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria,2JSFC@204441|Rhodospirillales	204441|Rhodospirillales	L	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_521412_1	983917.RGE_35830	5.81e-46	160.0	COG1773@1|root,COG1773@2|Bacteria,1MV2U@1224|Proteobacteria,2VKNQ@28216|Betaproteobacteria,1KKHX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	HupH hydrogenase expression protein, C-terminal conserved region	hoxQ	-	-	ko:K03618	-	-	-	-	ko00000	-	-	-	HupH_C
k59_231790_1	1328313.DS2_01983	2.17e-50	168.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,464N4@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
k59_231790_2	105559.Nwat_1496	1.45e-11	63.5	COG2022@1|root,COG2104@1|root,COG2022@2|Bacteria,COG2104@2|Bacteria,1N0N5@1224|Proteobacteria,1RMPD@1236|Gammaproteobacteria,1WW65@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
k59_640666_1	768671.ThimaDRAFT_0961	3.43e-100	315.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales	135613|Chromatiales	E	Vitamin B12 dependent methionine synthase activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_1811265_1	667632.KB890194_gene3494	4.51e-71	226.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2VI9P@28216|Betaproteobacteria,1JZMJ@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_173985_2	765911.Thivi_1736	1.86e-44	149.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1WVXJ@135613|Chromatiales	135613|Chromatiales	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
k59_464971_1	1304275.C41B8_01275	8.04e-101	320.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_879370_1	1121013.P873_12860	4.34e-44	161.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1X4XY@135614|Xanthomonadales	135614|Xanthomonadales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_1756438_1	933262.AXAM01000022_gene3222	1.51e-46	169.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,42P8Y@68525|delta/epsilon subdivisions,2WJYW@28221|Deltaproteobacteria,2MIZ7@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Von Willebrand factor type A	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA
k59_581736_1	2340.JV46_14290	1.64e-153	450.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_1639432_1	748449.Halha_0053	2.9e-52	176.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,3WAF8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Pyruvate flavodoxin ferredoxin oxidoreductase	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_1701075_2	62928.azo2207	1.44e-51	175.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHGM@28216|Betaproteobacteria,2KVQ7@206389|Rhodocyclales	206389|Rhodocyclales	P	Belongs to the ABC transporter superfamily	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
k59_1701078_3	28229.ND2E_3692	1.41e-10	63.2	2CAM1@1|root,301FE@2|Bacteria,1RJ36@1224|Proteobacteria,1S7TX@1236|Gammaproteobacteria,2Q86Q@267889|Colwelliaceae	1236|Gammaproteobacteria	S	Ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase
k59_349093_1	935839.JAGJ01000003_gene1479	1.16e-96	296.0	COG2256@1|root,COG2256@2|Bacteria,2GKDP@201174|Actinobacteria,4F38M@85017|Promicromonosporaceae	201174|Actinobacteria	L	MgsA AAA+ ATPase C terminal	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_1582179_1	187272.Mlg_2578	1.82e-91	282.0	COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,1RPGZ@1236|Gammaproteobacteria,1WWD2@135613|Chromatiales	135613|Chromatiales	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
k59_1811289_1	1502851.FG93_05148	1.44e-77	248.0	COG0747@1|root,COG0747@2|Bacteria,1MWBH@1224|Proteobacteria	1224|Proteobacteria	E	ABC-type dipeptide transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
k59_879393_1	177437.HRM2_16030	1.06e-39	146.0	COG2770@1|root,COG2770@2|Bacteria,1REI3@1224|Proteobacteria,42T9M@68525|delta/epsilon subdivisions,2WPWU@28221|Deltaproteobacteria,2MKDT@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,dCache_1
k59_1120699_1	1121405.dsmv_0296	1.67e-51	175.0	COG0739@1|root,COG0739@2|Bacteria,1NESH@1224|Proteobacteria,42MGB@68525|delta/epsilon subdivisions,2WJ7F@28221|Deltaproteobacteria,2MI1U@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1120699_2	439235.Dalk_1368	1.32e-34	128.0	COG1900@1|root,COG1900@2|Bacteria,1P1MT@1224|Proteobacteria,42M1I@68525|delta/epsilon subdivisions,2WIQ2@28221|Deltaproteobacteria,2MJ1R@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Homocysteine biosynthesis enzyme, sulfur-incorporation	-	-	-	-	-	-	-	-	-	-	-	-	HcyBio
k59_768418_1	177437.HRM2_00660	1.62e-102	327.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,42P6X@68525|delta/epsilon subdivisions,2WK8U@28221|Deltaproteobacteria,2MN0V@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
k59_1766875_1	1415780.JPOG01000001_gene1153	2.8e-09	60.5	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1X436@135614|Xanthomonadales	135614|Xanthomonadales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2
k59_67945_1	743718.Isova_2567	1.91e-55	190.0	COG0438@1|root,COG0438@2|Bacteria,2I005@201174|Actinobacteria	201174|Actinobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_9260_1	589873.EP13_07435	3.17e-43	150.0	COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,1S6CS@1236|Gammaproteobacteria,466UR@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Prokaryotic cytochrome b561	cybP	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_9260_2	1033802.SSPSH_003469	1.14e-41	145.0	COG2859@1|root,COG2859@2|Bacteria,1QU0K@1224|Proteobacteria,1RR22@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09797	-	-	-	-	ko00000	-	-	-	SIMPL
k59_1415355_1	880072.Desac_2886	6.95e-09	55.1	COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,42VAI@68525|delta/epsilon subdivisions,2WRI4@28221|Deltaproteobacteria,2MQNG@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_1415355_2	880072.Desac_2885	1.34e-96	285.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NR9@68525|delta/epsilon subdivisions,2WKX1@28221|Deltaproteobacteria,2MQSN@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1239677_1	523791.Kkor_0228	2.55e-65	222.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1XIUV@135619|Oceanospirillales	135619|Oceanospirillales	NT	chemotaxis protein	-	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	MCPsignal,PilJ
k59_416916_1	1122951.ATUE01000006_gene1498	1.94e-130	395.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,3NIPR@468|Moraxellaceae	1236|Gammaproteobacteria	I	Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate	fadB	GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8	ko:K01782,ko:K01825	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	iLF82_1304.LF82_0614,iNRG857_1313.NRG857_19200	3HCDH,3HCDH_N,ECH_1
k59_416916_2	382245.ASA_4250	0.000118	43.5	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1Y5BR@135624|Aeromonadales	135624|Aeromonadales	I	Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate	fadB	-	1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8	ko:K01825	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_243099_1	903503.MEPCIT_321	3.32e-07	51.2	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_243099_2	1395571.TMS3_0110060	0.000491	45.1	COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	cytochrome C assembly protein	ypjD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
k59_1180209_1	396588.Tgr7_0931	7.3e-72	233.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,1RPKA@1236|Gammaproteobacteria,1WXPP@135613|Chromatiales	135613|Chromatiales	G	pfam mofrl	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
k59_1708438_1	219305.MCAG_02708	3.56e-23	103.0	COG0582@1|root,COG0582@2|Bacteria,2IHIW@201174|Actinobacteria,4DA65@85008|Micromonosporales	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
k59_1532256_1	1348114.OM33_20050	1.78e-32	119.0	COG2930@1|root,COG2930@2|Bacteria,1RCYH@1224|Proteobacteria,1S41U@1236|Gammaproteobacteria,2Q48C@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Las17-binding protein actin regulator	CT2216	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_1532256_2	1122603.ATVI01000008_gene2317	2.19e-107	341.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X41A@135614|Xanthomonadales	135614|Xanthomonadales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_243113_1	760192.Halhy_6389	8.57e-42	149.0	COG1131@1|root,COG1131@2|Bacteria,4NEH0@976|Bacteroidetes,1IQ87@117747|Sphingobacteriia	976|Bacteroidetes	V	COG1131 ABC-type multidrug transport system ATPase component	gldA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1474607_1	1095767.CAHD01000214_gene649	3.18e-130	385.0	COG0147@1|root,COG0147@2|Bacteria,2GKJT@201174|Actinobacteria,4F0MA@85016|Cellulomonadaceae	201174|Actinobacteria	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_1120709_1	395493.BegalDRAFT_3318	2.15e-203	588.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,4608B@72273|Thiotrichales	72273|Thiotrichales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_768427_2	439235.Dalk_1208	2.64e-43	157.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria,2MIMQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3394)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_1063451_1	1211813.CAPH01000003_gene1349	5.42e-07	51.2	COG0110@1|root,COG0110@2|Bacteria,4NNWE@976|Bacteroidetes	976|Bacteroidetes	S	Acetyltransferase (Isoleucine patch superfamily)	maa	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2,Mac
k59_1063451_2	1122978.AUFP01000011_gene550	3.49e-15	77.4	COG0399@1|root,COG0399@2|Bacteria,4NEBI@976|Bacteroidetes,2FPAJ@200643|Bacteroidia	976|Bacteroidetes	E	Belongs to the DegT DnrJ EryC1 family	eryC	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
k59_1063451_3	1032480.MLP_25810	1.62e-09	60.5	COG1216@1|root,COG1887@1|root,COG1216@2|Bacteria,COG1887@2|Bacteria,2GM0T@201174|Actinobacteria,4DMYW@85009|Propionibacteriales	201174|Actinobacteria	M	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase	-	-	2.7.8.12	ko:K09809	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2,Glyphos_transf
k59_1300884_1	493475.GARC_1986	5.57e-61	200.0	COG0577@1|root,COG0577@2|Bacteria,1PVW8@1224|Proteobacteria,1SZYK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
k59_534658_1	1316936.K678_05101	2.62e-75	248.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2TRMJ@28211|Alphaproteobacteria,2JPN7@204441|Rhodospirillales	204441|Rhodospirillales	L	ATP-dependent helicase	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_1590706_1	998674.ATTE01000001_gene811	4.43e-88	273.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,45ZTS@72273|Thiotrichales	72273|Thiotrichales	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_534660_1	1713.JOFV01000002_gene663	1.73e-53	181.0	COG2267@1|root,COG2267@2|Bacteria,2GQC1@201174|Actinobacteria,4F25Z@85016|Cellulomonadaceae	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
k59_361464_1	768671.ThimaDRAFT_2599	1.55e-86	263.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1WWUT@135613|Chromatiales	135613|Chromatiales	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1474638_1	762376.AXYL_02922	1.08e-57	186.0	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,2VT65@28216|Betaproteobacteria,3T7BK@506|Alcaligenaceae	28216|Betaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_534669_1	1123020.AUIE01000028_gene2544	2.81e-58	187.0	COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,1S4SZ@1236|Gammaproteobacteria,1YFYU@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Lipocalin-like domain	blc	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
k59_768449_1	765912.Thimo_0297	3.97e-127	391.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1WVW8@135613|Chromatiales	135613|Chromatiales	EF	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_299875_1	870187.Thini_0232	1.37e-73	228.0	COG0727@1|root,COG0727@2|Bacteria,1N1JR@1224|Proteobacteria,1SUCZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
k59_889829_1	637389.Acaty_c1093	1.15e-132	393.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,2NC4N@225057|Acidithiobacillales	225057|Acidithiobacillales	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	-	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
k59_1708476_1	1123401.JHYQ01000006_gene62	1.65e-96	287.0	COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,1RRMA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	transglutaminase-like	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_361492_1	349521.HCH_05426	3.56e-53	182.0	COG4773@1|root,COG4773@2|Bacteria,1QWRF@1224|Proteobacteria,1RN9A@1236|Gammaproteobacteria,1XHTP@135619|Oceanospirillales	135619|Oceanospirillales	P	Receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1300931_1	1163617.SCD_n01858	9.42e-20	83.2	COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria,2VTC8@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_1300931_2	326297.Sama_0932	1.32e-22	93.2	COG4968@1|root,COG4968@2|Bacteria,1N6QE@1224|Proteobacteria,1SCBS@1236|Gammaproteobacteria,2QC3C@267890|Shewanellaceae	1236|Gammaproteobacteria	NU	Type IV minor pilin ComP, DNA uptake sequence receptor	pilE	-	-	ko:K02655	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	ComP_DUS,N_methyl
k59_1590736_1	1121035.AUCH01000016_gene2121	1.6e-29	114.0	COG1522@1|root,COG1522@2|Bacteria,1NVYY@1224|Proteobacteria,2VHP8@28216|Betaproteobacteria,2KUR4@206389|Rhodocyclales	206389|Rhodocyclales	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1590736_2	1255043.TVNIR_1645	8.56e-35	124.0	COG1522@1|root,COG1522@2|Bacteria,1NVYY@1224|Proteobacteria,1S620@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	COG1522 Transcriptional regulators	nirL	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
k59_68019_1	765912.Thimo_0912	1.29e-82	253.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,1RXYF@1236|Gammaproteobacteria,1WX0Z@135613|Chromatiales	135613|Chromatiales	L	PFAM integrase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve
k59_710703_1	76114.p2A163	7.89e-154	442.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW8A@1224|Proteobacteria,2VRJ7@28216|Betaproteobacteria,2KZUS@206389|Rhodocyclales	206389|Rhodocyclales	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_33
k59_1120748_1	525897.Dbac_1840	3.48e-84	265.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,42TI5@68525|delta/epsilon subdivisions,2WQR8@28221|Deltaproteobacteria,2MG9C@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_949662_1	398578.Daci_1979	0.000227	50.8	2DMSB@1|root,32TC4@2|Bacteria,1R9F1@1224|Proteobacteria,2W1R7@28216|Betaproteobacteria,4AG96@80864|Comamonadaceae	28216|Betaproteobacteria	S	SdrD B-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SdrD_B
k59_1591373_1	880072.Desac_2111	3.3e-88	285.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,43D31@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	nuoG2	-	1.12.7.2,1.17.1.10,1.17.1.9,1.6.5.3	ko:K00123,ko:K00336,ko:K05299,ko:K06441	ko00190,ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00190,map00630,map00680,map00720,map01100,map01120,map01200	M00144,M00377	R00019,R00134,R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_10,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1240655_1	1121396.KB893055_gene2594	1.23e-11	65.1	COG0107@1|root,COG0118@1|root,COG0107@2|Bacteria,COG0118@2|Bacteria,1MUS0@1224|Proteobacteria,42M44@68525|delta/epsilon subdivisions,2WJFW@28221|Deltaproteobacteria,2MIFH@213118|Desulfobacterales	28221|Deltaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K01663,ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase,His_biosynth
k59_1240655_2	391615.ABSJ01000034_gene1079	1.54e-86	260.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,1RN3M@1236|Gammaproteobacteria,1J5HX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16,5.3.1.24	ko:K01814,ko:K01817	ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230	M00023,M00026	R03509,R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_68987_1	1123400.KB904749_gene720	1.69e-93	295.0	COG1100@1|root,COG1100@2|Bacteria,1QXSV@1224|Proteobacteria,1S5FA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	50S ribosome-binding GTPase	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	DUF697,MMR_HSR1
k59_535314_1	1267005.KB911257_gene1094	1.11e-162	484.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,3N67P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1416122_1	471853.Bcav_2063	1.42e-141	430.0	COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria	201174|Actinobacteria	L	DEAD DEAH box helicase	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
k59_1121292_1	1304885.AUEY01000036_gene2247	2.63e-123	370.0	COG0591@1|root,COG0591@2|Bacteria,1PNHU@1224|Proteobacteria,43AQ2@68525|delta/epsilon subdivisions,2X63U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_1356991_1	933262.AXAM01000048_gene2601	0.000208	46.6	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,42MN4@68525|delta/epsilon subdivisions,2WJJ5@28221|Deltaproteobacteria,2MHRG@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Belongs to the GPAT DAPAT family	plsB	-	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_1240663_1	1385521.N803_02570	9.83e-89	269.0	COG0601@1|root,COG0601@2|Bacteria,2GJ2C@201174|Actinobacteria,4FEQC@85021|Intrasporangiaceae	201174|Actinobacteria	U	ABC transporter (Permease)	dppB	-	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
k59_476498_1	1122599.AUGR01000005_gene1835	5.28e-34	127.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1RN7K@1236|Gammaproteobacteria,1XR9V@135619|Oceanospirillales	135619|Oceanospirillales	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_68990_2	580332.Slit_0981	6e-05	47.0	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2VH5F@28216|Betaproteobacteria,44VRA@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase,HTH_6,SIS
k59_1240664_1	614083.AWQR01000053_gene3395	4.87e-132	398.0	COG5322@1|root,COG5322@2|Bacteria,1R60X@1224|Proteobacteria	1224|Proteobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	Semialdhyde_dh
k59_1064685_1	570268.ANBB01000012_gene5472	4.03e-18	83.2	COG1670@1|root,COG1670@2|Bacteria,2IKXU@201174|Actinobacteria	201174|Actinobacteria	J	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_1301869_1	517417.Cpar_1034	5.3e-29	105.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	rbpA	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_1301869_2	933262.AXAM01000019_gene1127	8.25e-34	116.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WR92@28221|Deltaproteobacteria,2MKYU@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM Cold-shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_244450_1	870187.Thini_4465	2.78e-124	364.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,460BA@72273|Thiotrichales	72273|Thiotrichales	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_1532928_1	472759.Nhal_3576	5.26e-17	77.8	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,1S4N8@1236|Gammaproteobacteria,1WWRR@135613|Chromatiales	135613|Chromatiales	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
k59_1532928_2	1279017.AQYJ01000026_gene364	7.55e-90	272.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1RNU8@1236|Gammaproteobacteria,465FZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Belongs to the SUA5 family	yciO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
k59_300499_1	765914.ThisiDRAFT_1406	0.000371	48.9	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,EAL,GAF_2,GGDEF,PAS_9
k59_1301878_1	1033802.SSPSH_003092	2.37e-89	266.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_1357006_1	323261.Noc_1721	7.35e-70	219.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1WWC4@135613|Chromatiales	135613|Chromatiales	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_1650951_2	1120950.KB892790_gene2051	1.3e-49	175.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,2GYM5@201174|Actinobacteria,4DSZ1@85009|Propionibacteriales	201174|Actinobacteria	C	Nickel-dependent hydrogenase	hycE	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
k59_362483_1	292415.Tbd_2047	7.09e-62	196.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ3Z@28216|Betaproteobacteria,1KSPA@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Pro_isomerase
k59_244471_1	331869.BAL199_15543	1.72e-61	202.0	COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2TVMG@28211|Alphaproteobacteria,4BQFR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	NADH pyrophosphatase-like rudimentary NUDIX domain	nudC	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
k59_1064710_1	926560.KE387026_gene4175	4.19e-71	222.0	COG0842@1|root,COG0842@2|Bacteria,1WM4H@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
k59_417618_1	1283300.ATXB01000001_gene2233	1.61e-117	360.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1XDP7@135618|Methylococcales	135618|Methylococcales	F	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_1532943_2	42256.RradSPS_0982	4.27e-24	95.9	COG1006@1|root,COG1006@2|Bacteria,2GSHQ@201174|Actinobacteria	201174|Actinobacteria	P	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
k59_1475693_1	871968.DESME_12040	2.16e-72	243.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,25ZY7@186807|Peptococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_949707_1	3712.Bo2g011460.1	4.09e-41	150.0	COG0481@1|root,KOG0462@2759|Eukaryota,37K2D@33090|Viridiplantae,3GBUJ@35493|Streptophyta,3HX75@3699|Brassicales	35493|Streptophyta	J	Elongation factor	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009507,GO:0009536,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0031647,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050821,GO:0050896,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_949707_2	861454.HMPREF9099_01158	7.98e-14	70.5	COG0632@1|root,COG0632@2|Bacteria,1V3KF@1239|Firmicutes,24JKV@186801|Clostridia,27MRB@186928|unclassified Lachnospiraceae	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
k59_1650959_1	1408473.JHXO01000014_gene4053	2.91e-68	233.0	COG3250@1|root,COG3250@2|Bacteria,4NGZD@976|Bacteroidetes,2G08E@200643|Bacteroidia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Glyco_hydro_43
k59_769024_1	1499967.BAYZ01000020_gene5232	6.33e-77	243.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K17241	ko02010,map02010	M00600	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.39	-	-	SBP_bac_1,SBP_bac_8
k59_593940_1	1122603.ATVI01000001_gene1914	6e-42	146.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,1RMGB@1236|Gammaproteobacteria,1X4AQ@135614|Xanthomonadales	135614|Xanthomonadales	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
k59_244491_1	1184607.AUCHE_09_00450	8.18e-101	305.0	COG1085@1|root,COG1085@2|Bacteria,2IA73@201174|Actinobacteria,4F63M@85018|Dermatophilaceae	201174|Actinobacteria	C	Domain of unknown function (DUF4921)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4921
k59_828618_1	1348663.KCH_75600	8.74e-85	257.0	COG1309@1|root,COG1309@2|Bacteria,2IN5P@201174|Actinobacteria,2M4JQ@2063|Kitasatospora	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1416168_1	911239.CF149_18821	9.35e-33	123.0	COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,1S5WA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Thiol disulfide interchange protein	dsbA	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K03673	ko01503,map01503	M00728	-	-	ko00000,ko00001,ko00002,ko03110	-	-	-	DSBA,Thioredoxin_4
k59_949728_1	765912.Thimo_2520	1.78e-60	200.0	COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,1RQW0@1236|Gammaproteobacteria,1X1HR@135613|Chromatiales	135613|Chromatiales	M	ABC-type transport system, involved in lipoprotein release, permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1591421_1	631362.Thi970DRAFT_02291	4.02e-85	273.0	COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,1WWRD@135613|Chromatiales	135613|Chromatiales	M	HAD-superfamily hydrolase, subfamily IIB	-	-	2.4.1.14	ko:K00696	ko00500,ko01100,map00500,map01100	-	R00766	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth
k59_1416169_2	765912.Thimo_3521	1.86e-64	215.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,1WW1M@135613|Chromatiales	135613|Chromatiales	S	ErfK YbiS YcfS YnhG family protein	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_10764_1	96561.Dole_1855	2.03e-36	132.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2WMQ8@28221|Deltaproteobacteria,2MJAD@213118|Desulfobacterales	28221|Deltaproteobacteria	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
k59_1010940_1	998674.ATTE01000001_gene2156	3.85e-17	86.7	COG1028@1|root,COG3693@1|root,COG1028@2|Bacteria,COG3693@2|Bacteria,1MWC8@1224|Proteobacteria,1S1X8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	Belongs to the glycosyl hydrolase 8 (cellulase D) family	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_602024_1	243159.AFE_2678	1.53e-43	157.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,2NCD0@225057|Acidithiobacillales	225057|Acidithiobacillales	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_902646_1	998088.B565_2709	2.52e-18	84.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,1Y3UK@135624|Aeromonadales	135624|Aeromonadales	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_902646_2	1452718.JBOY01000011_gene3274	3.14e-35	127.0	COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,1S6WD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein	dsbB	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
k59_133312_1	251229.Chro_4812	1.41e-55	197.0	COG2372@1|root,COG2372@2|Bacteria	2|Bacteria	C	response to copper ion	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082,SASA,SLH
k59_1487379_1	1454010.JEOE01000001_gene703	6.12e-109	343.0	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,4F0NB@85016|Cellulomonadaceae	201174|Actinobacteria	EF	Carbamoyl-phosphate synthetase large chain domain protein	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_1313802_1	768671.ThimaDRAFT_1857	5.17e-26	107.0	COG2304@1|root,COG2304@2|Bacteria,1QU8I@1224|Proteobacteria,1T1VP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1313802_2	768671.ThimaDRAFT_1763	9.98e-55	174.0	COG3492@1|root,COG3492@2|Bacteria,1MZ3I@1224|Proteobacteria,1S8SI@1236|Gammaproteobacteria,1WYYF@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1244)	-	-	-	ko:K09948	-	-	-	-	ko00000	-	-	-	DUF1244
k59_1425008_1	387631.Asulf_01075	6.48e-13	70.1	COG0680@1|root,arCOG04429@2157|Archaea,2Y6E1@28890|Euryarchaeota,247E7@183980|Archaeoglobi	183980|Archaeoglobi	O	hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
k59_1425008_2	909663.KI867150_gene1871	1.12e-12	67.8	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,42N63@68525|delta/epsilon subdivisions,2WJPA@28221|Deltaproteobacteria,2MQRM@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM nickel-dependent hydrogenase, large subunit	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_258412_1	768671.ThimaDRAFT_4570	1.41e-22	89.7	COG1720@1|root,COG1720@2|Bacteria,1MUF0@1224|Proteobacteria,1S81I@1236|Gammaproteobacteria,1WYKH@135613|Chromatiales	135613|Chromatiales	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
k59_543672_1	754477.Q7C_1190	5.86e-26	110.0	COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,1RP5U@1236|Gammaproteobacteria,46010@72273|Thiotrichales	72273|Thiotrichales	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_1841995_1	754477.Q7C_1790	1.54e-137	420.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,45ZWK@72273|Thiotrichales	72273|Thiotrichales	M	TIGRFAM penicillin-binding protein, 1A	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_1841995_2	1158182.KB905023_gene1404	1.81e-07	52.4	COG1418@1|root,COG1418@2|Bacteria,1MZUS@1224|Proteobacteria,1S5FK@1236|Gammaproteobacteria,1WYFS@135613|Chromatiales	135613|Chromatiales	S	mRNA catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_543675_1	765911.Thivi_0052	8.7e-102	313.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1WW0Z@135613|Chromatiales	135613|Chromatiales	CI	TIGRFAM Oxaloacetate decarboxylase, alpha subunit	-	-	6.4.1.1	ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_1775829_2	1249627.D779_3272	5.44e-15	74.3	2C8T8@1|root,32RMU@2|Bacteria,1N089@1224|Proteobacteria,1SAT4@1236|Gammaproteobacteria,1WYU4@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1775829_3	765911.Thivi_2614	7.03e-121	355.0	COG0727@1|root,COG0727@2|Bacteria,1R3YG@1224|Proteobacteria,1RQT5@1236|Gammaproteobacteria,1X0G7@135613|Chromatiales	135613|Chromatiales	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_1659883_1	1411123.JQNH01000001_gene3276	1.41e-22	101.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2UP6H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3
k59_1190041_1	1122604.JONR01000011_gene3728	4.03e-48	175.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1X46R@135614|Xanthomonadales	135614|Xanthomonadales	E	glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH,GDH_N
k59_1599737_1	593907.Celgi_2472	3.96e-75	237.0	COG2890@1|root,COG2890@2|Bacteria,2GMH1@201174|Actinobacteria,4F0XJ@85016|Cellulomonadaceae	201174|Actinobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_25,Methyltransf_31
k59_1313823_1	864702.OsccyDRAFT_0407	5.33e-15	80.1	COG0763@1|root,COG0763@2|Bacteria,1G21F@1117|Cyanobacteria,1H8C1@1150|Oscillatoriales	1117|Cyanobacteria	M	Lipid A disaccharide synthetase	-	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	-
k59_258428_1	1499967.BAYZ01000118_gene3302	2.96e-83	255.0	COG0697@1|root,COG0697@2|Bacteria,2NRS8@2323|unclassified Bacteria	2|Bacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_133331_1	1121434.AULY01000006_gene583	1.09e-33	130.0	COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,42NGP@68525|delta/epsilon subdivisions,2WIZN@28221|Deltaproteobacteria,2M84P@213115|Desulfovibrionales	28221|Deltaproteobacteria	N	Flagellar hook protein FlgE	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
k59_80884_1	697282.Mettu_1844	3.66e-07	52.0	COG4590@1|root,COG4590@2|Bacteria,1QTTD@1224|Proteobacteria,1T1GK@1236|Gammaproteobacteria,1XEGE@135618|Methylococcales	135618|Methylococcales	P	PFAM Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_80884_3	1121374.KB891576_gene479	8.81e-167	474.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,1RQDH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	phosphate	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_80884_4	1366050.N234_13975	9.18e-29	114.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2VIBV@28216|Betaproteobacteria,1K20K@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3329,HATPase_c,HisKA,PAS,PAS_8
k59_1365478_1	335543.Sfum_1741	7.49e-21	95.1	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,42NKH@68525|delta/epsilon subdivisions,2WJTY@28221|Deltaproteobacteria,2MRGC@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Belongs to the helicase family. UvrD subfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1190051_1	1042377.AFPJ01000028_gene2227	5.16e-47	167.0	COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,1T1KJ@1236|Gammaproteobacteria,46621@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	COG1505 Serine proteases of the peptidase family S9A	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_602060_1	861299.J421_1512	2.31e-40	148.0	COG2270@1|root,COG2270@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	cmr	-	2.7.4.9	ko:K00943,ko:K08217,ko:K18833	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	br01600,ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.2,2.A.1.21.22	-	-	MFS_1,MFS_3
k59_258443_1	1089550.ATTH01000001_gene491	1.8e-121	374.0	COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,4NFGR@976|Bacteroidetes,1FIND@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	homoserine dehydrogenase	-	-	1.1.1.3,2.7.2.4	ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7,Homoserine_dh,NAD_binding_3
k59_602062_1	571166.KI421509_gene2496	1.26e-55	182.0	COG1737@1|root,COG1737@2|Bacteria,1N3YS@1224|Proteobacteria,2TTJD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
k59_1365485_1	393595.ABO_1160	1.2e-40	151.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1XJI1@135619|Oceanospirillales	135619|Oceanospirillales	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
k59_192036_1	1298593.TOL_1294	1.43e-38	137.0	COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,1RNAD@1236|Gammaproteobacteria,1XH66@135619|Oceanospirillales	135619|Oceanospirillales	EH	Sulfate adenylyltransferase subunit 2	cysD	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
k59_192036_2	1219049.SP5_001_01320	2.64e-62	209.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2TQNJ@28211|Alphaproteobacteria,2K22T@204457|Sphingomonadales	204457|Sphingomonadales	P	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysC	-	2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU,GTP_EFTU_D2
k59_80898_1	29495.EA26_17385	2.54e-05	47.0	COG4589@1|root,COG4589@2|Bacteria,1R34Q@1224|Proteobacteria,1T63B@1236|Gammaproteobacteria,1XSRD@135623|Vibrionales	135623|Vibrionales	S	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
k59_80898_2	1283300.ATXB01000001_gene249	2.75e-58	189.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,1XEM4@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_1842037_1	765912.Thimo_1749	8.2e-31	118.0	28KIA@1|root,2ZA3I@2|Bacteria,1MXIF@1224|Proteobacteria,1RMA6@1236|Gammaproteobacteria,1WX53@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1842037_2	292415.Tbd_0749	7.18e-34	127.0	COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,2VS6Y@28216|Betaproteobacteria,1KSGS@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Putative metallopeptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2201,DUF2201_N
k59_192041_1	631362.Thi970DRAFT_04554	2.99e-76	236.0	COG3005@1|root,COG3005@2|Bacteria,1QZ6I@1224|Proteobacteria,1RXZD@1236|Gammaproteobacteria,1X0FD@135613|Chromatiales	135613|Chromatiales	C	PFAM Class III cytochrome C family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_80904_1	713586.KB900536_gene593	2.54e-25	105.0	COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins	zipA	GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0022402,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032506,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047	-	ko:K03528	-	-	-	-	ko00000,ko03036	-	-	-	ZipA_C
k59_80904_2	1042209.HK44_023015	2.9e-07	51.6	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1YNGT@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_776037_1	1123008.KB905697_gene3186	0.000912	47.0	COG0598@1|root,COG0598@2|Bacteria,4NG3C@976|Bacteroidetes,2FPIV@200643|Bacteroidia,22XS7@171551|Porphyromonadaceae	976|Bacteroidetes	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_776037_2	235985.BBPN01000008_gene3953	2.35e-19	82.8	COG1846@1|root,COG1846@2|Bacteria,2IMGG@201174|Actinobacteria,2NMS7@228398|Streptacidiphilus	201174|Actinobacteria	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
k59_1487423_1	670307.HYPDE_24253	5.76e-38	132.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2UCYK@28211|Alphaproteobacteria,3N72F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1487423_2	187303.BN69_0109	1.13e-59	188.0	COG1853@1|root,COG1853@2|Bacteria,1NB1B@1224|Proteobacteria,2U5NM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	flavin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
k59_308861_1	367299.JOEE01000006_gene895	1.22e-131	386.0	COG4284@1|root,COG4284@2|Bacteria,2I2G3@201174|Actinobacteria,4FEYE@85021|Intrasporangiaceae	201174|Actinobacteria	G	UTP--glucose-1-phosphate uridylyltransferase	ugpA	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPGP
k59_192043_1	1454010.JEOE01000048_gene1482	8.92e-65	214.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria,4F25C@85016|Cellulomonadaceae	201174|Actinobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	thiP	-	-	ko:K02011,ko:K02063	ko02010,map02010	M00190,M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10,3.A.1.19	-	-	BPD_transp_1
k59_192043_2	1304865.JAGF01000001_gene1464	1.9e-26	106.0	COG4143@1|root,COG4143@2|Bacteria,2GMWD@201174|Actinobacteria,4F20D@85016|Cellulomonadaceae	201174|Actinobacteria	P	TIGRFAM ABC transporter, periplasmic binding protein, thiB subfamily	tbpA	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6
k59_1425049_1	593907.Celgi_1930	1e-102	303.0	COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria,4F327@85016|Cellulomonadaceae	201174|Actinobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_1078264_1	1123504.JQKD01000002_gene3997	1.47e-102	319.0	COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2VJ0J@28216|Betaproteobacteria,4AD4F@80864|Comamonadaceae	28216|Betaproteobacteria	E	Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
k59_1365500_1	631362.Thi970DRAFT_03279	2.27e-41	155.0	COG0457@1|root,COG0457@2|Bacteria,1MXK4@1224|Proteobacteria,1RNFM@1236|Gammaproteobacteria,1WXT3@135613|Chromatiales	135613|Chromatiales	S	Oxygen tolerance	-	-	-	-	-	-	-	-	-	-	-	-	BatD
k59_1252444_1	1089455.MOPEL_022_00280	4.2e-76	248.0	COG1770@1|root,COG1770@2|Bacteria,2GNA9@201174|Actinobacteria,4F6IM@85018|Dermatophilaceae	201174|Actinobacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_80913_1	765911.Thivi_2155	4.72e-152	434.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1WX6I@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_308872_1	525897.Dbac_0034	1.7e-15	78.2	COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,42NNZ@68525|delta/epsilon subdivisions,2WJ7C@28221|Deltaproteobacteria,2M8N2@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Peptidase dimerisation domain	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_308872_2	1114970.PSF113_0178	5.29e-07	55.1	COG0784@1|root,COG1639@1|root,COG0784@2|Bacteria,COG1639@2|Bacteria,1QR40@1224|Proteobacteria,1RTXG@1236|Gammaproteobacteria,1YMFK@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD,Response_reg
k59_1717414_1	95619.PM1_0216345	5.15e-65	207.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,1RQJT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_308874_1	471853.Bcav_1010	1.92e-78	255.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_192059_1	396588.Tgr7_2039	2.1e-09	58.5	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1WVW1@135613|Chromatiales	135613|Chromatiales	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7,Fer4_8
k59_1252454_1	1131553.JIBI01000005_gene2192	2.4e-50	173.0	COG0589@1|root,COG0589@2|Bacteria,1PE08@1224|Proteobacteria,2VNHV@28216|Betaproteobacteria,373RK@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1717420_1	367299.JOEE01000002_gene2531	1.19e-67	211.0	COG0412@1|root,COG0412@2|Bacteria,2GJMH@201174|Actinobacteria,4FGJ9@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_1717420_2	1193181.BN10_540012	1.99e-38	129.0	COG1694@1|root,COG1694@2|Bacteria,2ISAF@201174|Actinobacteria,4FJCG@85021|Intrasporangiaceae	201174|Actinobacteria	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	MazG
k59_1313900_1	1292035.H476_0911	1.63e-14	74.7	COG0760@1|root,COG0760@2|Bacteria,1V5Q2@1239|Firmicutes,248JQ@186801|Clostridia,25SC0@186804|Peptostreptococcaceae	186801|Clostridia	O	peptidyl-prolyl isomerase	prsA2	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3
k59_192065_1	1304865.JAGF01000001_gene1840	5.01e-52	184.0	COG1165@1|root,COG1165@2|Bacteria,2GMEB@201174|Actinobacteria,4F12X@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
k59_1776595_1	251229.Chro_4750	9.6e-39	144.0	COG0232@1|root,COG0232@2|Bacteria,1G32E@1117|Cyanobacteria,3VIG3@52604|Pleurocapsales	1117|Cyanobacteria	F	TIGRFAM deoxyguanosinetriphosphate triphosphohydrolase	-	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	iJN678.dgt	HD,HD_assoc
k59_1425811_1	1043493.BBLU01000018_gene1535	2.12e-57	193.0	COG4320@1|root,COG4320@2|Bacteria,2GKEK@201174|Actinobacteria	201174|Actinobacteria	K	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
k59_838095_1	1249627.D779_2153	1.05e-15	77.8	COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,1RRYZ@1236|Gammaproteobacteria,1WVZM@135613|Chromatiales	135613|Chromatiales	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_7
k59_1079292_1	1502851.FG93_06077	5.07e-51	174.0	COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,2U874@28211|Alphaproteobacteria,3JRK1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2
k59_1253385_1	639030.JHVA01000001_gene3472	1.26e-85	276.0	COG3408@1|root,COG3408@2|Bacteria,3Y47W@57723|Acidobacteria,2JKGP@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
k59_1600510_2	1167006.UWK_01711	6.07e-12	64.7	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,42MRR@68525|delta/epsilon subdivisions,2WIQ7@28221|Deltaproteobacteria,2MIGW@213118|Desulfobacterales	28221|Deltaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_602818_1	670307.HYPDE_31213	9.51e-111	323.0	COG5424@1|root,COG5424@2|Bacteria,1MW7G@1224|Proteobacteria,2TSQT@28211|Alphaproteobacteria,3N6JP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	pqqC	-	1.3.3.11	ko:K06136,ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	TENA_THI-4
k59_962760_1	1280954.HPO_16705	2.59e-46	151.0	COG2963@1|root,COG2963@2|Bacteria,1N8Y3@1224|Proteobacteria,2UY60@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase, IS3 IS911 family protein	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_962760_2	1163408.UU9_16021	1.8e-06	50.1	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1XCRK@135614|Xanthomonadales	135614|Xanthomonadales	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
k59_375526_1	765914.ThisiDRAFT_1160	1.12e-52	175.0	COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,1RNAA@1236|Gammaproteobacteria,1WWKH@135613|Chromatiales	135613|Chromatiales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_602819_1	1267005.KB911256_gene2028	9.36e-82	255.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2TW3U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_776632_1	1304865.JAGF01000001_gene2497	1.09e-78	246.0	COG1609@1|root,COG1609@2|Bacteria,2GJV7@201174|Actinobacteria,4F0RV@85016|Cellulomonadaceae	201174|Actinobacteria	K	PFAM periplasmic binding protein LacI transcriptional regulator	celR	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
k59_549662_1	269798.CHU_1289	4.2e-104	306.0	COG0207@1|root,COG0207@2|Bacteria,4NEC2@976|Bacteroidetes,47KE8@768503|Cytophagia	976|Bacteroidetes	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
k59_432286_1	1121015.N789_04295	5.76e-80	251.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0C@1236|Gammaproteobacteria,1X3N0@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.18	ko:K00822	ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100	-	R00907,R04187	RC00008,RC00062,RC00160	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_383356_1	933262.AXAM01000004_gene2390	3.63e-19	87.4	COG2202@1|root,COG4585@1|root,COG2202@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,42SJA@68525|delta/epsilon subdivisions,2WPP4@28221|Deltaproteobacteria,2MK2H@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA_3,PAS,PAS_4,PAS_8,PAS_9,Response_reg
k59_383356_2	1174528.JH992898_gene2794	6.89e-25	98.2	COG0745@1|root,COG0745@2|Bacteria,1GQUJ@1117|Cyanobacteria,1JM4Q@1189|Stigonemataceae	1117|Cyanobacteria	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_1723649_1	118173.KB235914_gene2652	5.92e-18	82.4	COG3900@1|root,COG3900@2|Bacteria,1G5FF@1117|Cyanobacteria,1HG0N@1150|Oscillatoriales	1117|Cyanobacteria	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
k59_1260538_1	1049564.TevJSym_ac00090	1.29e-77	245.0	COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,1RQ8F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Nitrous oxidase accessory protein	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
k59_432293_1	335659.S23_26900	1.73e-105	314.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2TSWA@28211|Alphaproteobacteria,3JRCS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glucose dehydrogenase C-terminus	MA20_31690	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_315250_1	159087.Daro_0523	1.32e-123	360.0	COG0753@1|root,COG0753@2|Bacteria,1MUXZ@1224|Proteobacteria,2VGZA@28216|Betaproteobacteria,2KV0A@206389|Rhodocyclales	206389|Rhodocyclales	C	Catalase	-	-	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase,Catalase-rel
k59_315250_2	159087.Daro_2248	3.18e-05	45.4	COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,2VQ6X@28216|Betaproteobacteria,2KW4E@206389|Rhodocyclales	206389|Rhodocyclales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
k59_1260542_1	765911.Thivi_4354	7.13e-105	336.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1WX8F@135613|Chromatiales	135613|Chromatiales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_1547431_1	1121405.dsmv_3405	2.31e-96	294.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria,2MIR1@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_726104_1	996637.SGM_3956	6.42e-34	125.0	COG0638@1|root,COG0638@2|Bacteria,2GJ60@201174|Actinobacteria	201174|Actinobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcB	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019774,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
k59_726104_2	1304865.JAGF01000001_gene3566	1.36e-18	78.2	2E9C2@1|root,333JS@2|Bacteria,2I1D6@201174|Actinobacteria,4F1MQ@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation	pup	-	-	ko:K13570	-	-	-	-	ko00000,ko04121	-	-	-	Pup
k59_726104_3	471853.Bcav_2240	1.05e-53	183.0	COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria	201174|Actinobacteria	S	proteasome accessory factor PafA2	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
k59_89842_1	572477.Alvin_1501	3.3e-66	225.0	COG0204@1|root,COG0236@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0236@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria,1WWF0@135613|Chromatiales	135613|Chromatiales	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Acyltransferase,PP-binding
k59_1605626_1	933262.AXAM01000028_gene3314	3.76e-56	181.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2WKMA@28221|Deltaproteobacteria,2MIAI@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_35093_2	765914.ThisiDRAFT_2037	2.97e-11	67.4	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WWRT@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,Response_reg
k59_970696_1	1049564.TevJSym_ad00260	1.37e-61	204.0	COG1008@1|root,COG1008@2|Bacteria,1R8V8@1224|Proteobacteria,1RZVG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	overlaps another CDS with the same product name	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1322885_2	710111.FraQA3DRAFT_1587	1.57e-52	171.0	2DT7J@1|root,33J1T@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1371526_2	511062.GU3_15280	2.15e-34	128.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1Y526@135624|Aeromonadales	135624|Aeromonadales	P	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_1723671_1	1125971.ASJB01000015_gene5587	8.9e-30	116.0	COG1051@1|root,COG1051@2|Bacteria,2I2YK@201174|Actinobacteria,4E65Q@85010|Pseudonocardiales	201174|Actinobacteria	F	belongs to the nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_1324677_1	1499967.BAYZ01000027_gene1783	1.19e-30	125.0	COG0768@1|root,COG0768@2|Bacteria,2NNWR@2323|unclassified Bacteria	2|Bacteria	M	Penicillin-binding Protein dimerisation domain	ftsI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.4.16.4	ko:K03587,ko:K08384,ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
k59_913477_1	323850.Shew_1851	1.55e-23	101.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,2QA8V@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_1197406_1	635013.TherJR_2186	1.61e-83	257.0	COG3621@1|root,COG3621@2|Bacteria,1UYFU@1239|Firmicutes,25DW4@186801|Clostridia	186801|Clostridia	S	PFAM Patatin	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_1548346_1	1415779.JOMH01000001_gene3278	7.83e-22	95.5	COG1999@1|root,COG1999@2|Bacteria,1N6R6@1224|Proteobacteria,1SC88@1236|Gammaproteobacteria,1X800@135614|Xanthomonadales	135614|Xanthomonadales	S	signal sequence binding	-	-	-	-	-	-	-	-	-	-	-	-	SCO1-SenC
k59_1548346_2	396588.Tgr7_3005	1.26e-07	52.4	COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,1S8S0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	SURF1-like protein	surf1	-	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
k59_1852984_1	887898.HMPREF0551_0330	2.47e-81	266.0	COG0749@1|root,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,1K0FY@119060|Burkholderiaceae	28216|Betaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_972521_1	96561.Dole_1461	2.63e-110	336.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MINQ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
k59_1782853_1	335543.Sfum_1732	7.68e-59	188.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,42QWD@68525|delta/epsilon subdivisions,2WNNG@28221|Deltaproteobacteria,2MRM5@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_913500_1	272568.GDI3087	5.11e-109	330.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TR6K@28211|Alphaproteobacteria,2JQ8V@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_385215_1	1123373.ATXI01000011_gene1121	4.26e-49	177.0	COG1200@1|root,COG1200@2|Bacteria,2GHAE@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_1197416_1	1123261.AXDW01000002_gene1524	9.33e-09	56.6	COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,1RMVD@1236|Gammaproteobacteria,1X39H@135614|Xanthomonadales	135614|Xanthomonadales	G	Inositol monophosphatase family	-	-	3.1.3.15	ko:K05602	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_1087553_1	1392487.JIAD01000001_gene780	7.19e-11	62.8	COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia,25VBI@186806|Eubacteriaceae	186801|Clostridia	G	Phosphotransfer between the C1 and C5 carbon atoms of pentose	deoB	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
k59_1087553_2	1122919.KB905563_gene2523	3.86e-91	271.0	COG1225@1|root,COG1225@2|Bacteria,1V058@1239|Firmicutes,4HE2H@91061|Bacilli,26T9E@186822|Paenibacillaceae	91061|Bacilli	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
k59_782224_1	1288494.EBAPG3_26320	2.94e-81	267.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,37225@32003|Nitrosomonadales	28216|Betaproteobacteria	IQ	AMP-dependent synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Acyltransferase,PP-binding
k59_36637_1	335543.Sfum_1328	2.61e-84	261.0	COG1453@1|root,COG1453@2|Bacteria,1RAU3@1224|Proteobacteria,43A0M@68525|delta/epsilon subdivisions,2X9UN@28221|Deltaproteobacteria,2MS7U@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PFAM aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red
k59_972552_1	460265.Mnod_0373	5.3e-28	114.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,1JUJU@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1606531_1	446469.Sked_08760	1.25e-62	201.0	COG1215@1|root,COG1215@2|Bacteria,2I2IY@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
k59_1724729_1	1386089.N865_12105	1.72e-157	452.0	COG0366@1|root,COG0366@2|Bacteria,2GJKR@201174|Actinobacteria,4FEN2@85021|Intrasporangiaceae	201174|Actinobacteria	G	Glycogen debranching enzyme, glucanotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Malt_amylase_C
k59_492134_1	593907.Celgi_1023	3.51e-29	112.0	COG2326@1|root,COG2326@2|Bacteria,2GKRN@201174|Actinobacteria,4F1TB@85016|Cellulomonadaceae	201174|Actinobacteria	S	Polyphosphate kinase 2 (PPK2)	ppk2	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005525,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006183,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030808,GO:0031323,GO:0031326,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046777,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051704,GO:0055086,GO:0062012,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0080090,GO:0090407,GO:0097159,GO:0097367,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
k59_1853020_1	686578.AFFX01000001_gene1609	1.08e-22	98.6	COG4796@1|root,COG4796@2|Bacteria,1RCNA@1224|Proteobacteria,1SE5I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Type II secretory pathway, component	-	-	-	-	-	-	-	-	-	-	-	-	Secretin,Secretin_N
k59_385234_1	404380.Gbem_0830	8.86e-13	67.8	COG1145@1|root,COG1145@2|Bacteria,1QW1N@1224|Proteobacteria,43CPX@68525|delta/epsilon subdivisions,2X7X5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
k59_385234_2	1120954.ATXE01000003_gene514	1.52e-12	70.9	COG1266@1|root,COG1266@2|Bacteria,2GMJ1@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_1372461_1	1335757.SPICUR_05000	8.75e-78	237.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1WX9S@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_1496200_1	472759.Nhal_2070	2.34e-122	380.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1WWJI@135613|Chromatiales	135613|Chromatiales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_1324743_2	887898.HMPREF0551_1888	2.19e-43	147.0	COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,2VRAK@28216|Betaproteobacteria,1K75Y@119060|Burkholderiaceae	28216|Betaproteobacteria	J	binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
k59_1324743_3	90814.KL370891_gene252	2.87e-08	52.0	COG1841@1|root,COG1841@2|Bacteria,1N6ZE@1224|Proteobacteria,1SC8N@1236|Gammaproteobacteria,4617P@72273|Thiotrichales	72273|Thiotrichales	J	Ribosomal protein L30	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
k59_1324743_4	1033802.SSPSH_003087	3.3e-33	119.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,1RNEV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_782234_2	1177154.Y5S_01808	1.32e-18	82.8	COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,1S9Z9@1236|Gammaproteobacteria,1XKPZ@135619|Oceanospirillales	135619|Oceanospirillales	C	cytochrome c5	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_668651_1	1211112.ALJC01000066_gene2468	3.92e-29	109.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO0053,iSDY_1059.SDY_4064	CTP_transf_like
k59_668651_2	75379.Tint_0743	2.32e-40	134.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,2VTZ1@28216|Betaproteobacteria,1KMCZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	4Fe-4S binding domain	fdx1	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
k59_198992_1	1502850.FG91_02442	5.96e-15	72.0	COG1670@1|root,COG1670@2|Bacteria,1PPMV@1224|Proteobacteria,2UC28@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_198992_2	472759.Nhal_3915	9.24e-26	96.7	COG1598@1|root,COG1598@2|Bacteria,1P4UT@1224|Proteobacteria	1224|Proteobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_198992_3	1123368.AUIS01000028_gene1313	1.55e-98	300.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	macB	-	-	ko:K02004,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	FtsX,MacB_PCD
k59_91775_1	935839.JAGJ01000003_gene1496	2.19e-61	192.0	COG0781@1|root,COG0781@2|Bacteria,2IM3D@201174|Actinobacteria,4F4IV@85017|Promicromonosporaceae	201174|Actinobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	GO:0008150,GO:0040007	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
k59_91775_2	471853.Bcav_2031	1.87e-40	137.0	COG0231@1|root,COG0231@2|Bacteria,2GJMS@201174|Actinobacteria	201174|Actinobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
k59_1324751_1	1123279.ATUS01000001_gene2623	6.63e-16	73.6	2EIP6@1|root,33CEJ@2|Bacteria,1NJA2@1224|Proteobacteria,1SHW0@1236|Gammaproteobacteria,1J771@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_550726_1	754476.Q7A_567	1.99e-43	145.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1S8RQ@1236|Gammaproteobacteria,460WA@72273|Thiotrichales	72273|Thiotrichales	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
k59_972581_1	933262.AXAM01000002_gene525	6.81e-74	248.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,42KZ7@68525|delta/epsilon subdivisions,2WJP6@28221|Deltaproteobacteria,2MIWZ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487	GATase_6,SIS
k59_198996_1	1123269.NX02_12365	1.73e-15	78.6	COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2TS6U@28211|Alphaproteobacteria,2K17G@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F
k59_36678_1	1454004.AW11_00034	1.11e-52	183.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2VHBA@28216|Betaproteobacteria	1224|Proteobacteria	S	CBS domain containing protein	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_36678_2	1454004.AW11_00033	1.29e-37	137.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2VHBA@28216|Betaproteobacteria	1224|Proteobacteria	S	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1135565_1	402777.KB235904_gene3063	4.94e-69	228.0	COG0153@1|root,COG1210@1|root,COG0153@2|Bacteria,COG1210@2|Bacteria,1G28Z@1117|Cyanobacteria,1H97B@1150|Oscillatoriales	1117|Cyanobacteria	M	UDP-glucose pyrophosphorylase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_36683_2	105559.Nwat_0309	6.46e-40	138.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1WX3P@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
k59_316367_1	1453501.JELR01000002_gene1254	5.64e-93	276.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,4643Y@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
k59_316367_2	34506.g2513	4.15e-17	80.1	COG1219@1|root,KOG0745@2759|Eukaryota,39XQQ@33154|Opisthokonta,3BMR9@33208|Metazoa,3DFBN@33213|Bilateria	33208|Metazoa	O	ATP-dependent protease ATPase subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
k59_1372488_1	446466.Cfla_1550	5.65e-12	64.3	COG0834@1|root,COG0834@2|Bacteria,2GJH8@201174|Actinobacteria,4F1V2@85016|Cellulomonadaceae	201174|Actinobacteria	ET	Bacterial periplasmic substrate-binding proteins	gluB	-	-	ko:K10005	ko02010,map02010	M00233	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.9	-	-	SBP_bac_3
k59_1372488_2	1095772.CAHH01000059_gene1376	9.05e-48	159.0	COG0765@1|root,COG0765@2|Bacteria,2GNUR@201174|Actinobacteria	201174|Actinobacteria	E	amino acid ABC transporter	gluC	-	-	ko:K10006,ko:K10040	ko02010,map02010	M00228,M00233	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.9	-	-	BPD_transp_1
k59_1724771_1	1380356.JNIK01000018_gene735	1.43e-15	80.5	COG0373@1|root,COG0373@2|Bacteria,2GJRA@201174|Actinobacteria,4ERHS@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	GO:0008150,GO:0040007	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_140446_1	886293.Sinac_7479	2.83e-10	68.6	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXDF@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,WD40
k59_91828_1	1265313.HRUBRA_01492	2.92e-126	366.0	COG1442@1|root,COG1442@2|Bacteria,1R5NA@1224|Proteobacteria,1SJX1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1606572_1	396588.Tgr7_1269	8.64e-122	356.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,1RNTJ@1236|Gammaproteobacteria,1WXHH@135613|Chromatiales	135613|Chromatiales	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
k59_1432515_1	177437.HRM2_10540	3.88e-38	136.0	COG1102@1|root,COG1102@2|Bacteria,1R9XZ@1224|Proteobacteria,42R78@68525|delta/epsilon subdivisions,2WN7X@28221|Deltaproteobacteria,2MJR4@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
k59_844656_1	999611.KI421504_gene495	1.11e-08	56.2	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,281XJ@191028|Leisingera	28211|Alphaproteobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_1782907_1	1265505.ATUG01000003_gene578	1.26e-35	132.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,42MM6@68525|delta/epsilon subdivisions,2WJ53@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve
k59_433378_1	395965.Msil_3700	1.52e-65	209.0	COG3931@1|root,COG3931@2|Bacteria,1QI71@1224|Proteobacteria,2TVK6@28211|Alphaproteobacteria,3NAA0@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FGase
k59_1606576_1	870187.Thini_0771	1.99e-86	263.0	COG1179@1|root,COG1179@2|Bacteria,1MWXR@1224|Proteobacteria,1RMT3@1236|Gammaproteobacteria,462SE@72273|Thiotrichales	72273|Thiotrichales	H	ThiF family	-	-	-	ko:K22132	-	-	-	-	ko00000,ko03016	-	-	-	ThiF
k59_556245_1	1335757.SPICUR_08660	1.93e-47	170.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1WW2F@135613|Chromatiales	135613|Chromatiales	P	Chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
k59_614882_1	438753.AZC_3082	9.39e-98	300.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2TRP9@28211|Alphaproteobacteria,3EYZC@335928|Xanthobacteraceae	28211|Alphaproteobacteria	P	TrkA-C domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_1611897_1	391615.ABSJ01000046_gene2115	8.89e-50	167.0	COG5660@1|root,2Z7TM@2|Bacteria,1PMCV@1224|Proteobacteria,1S21F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TRAP transporter T-component	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
k59_732761_1	1528106.JRJE01000008_gene1490	6.22e-61	199.0	COG0673@1|root,COG0673@2|Bacteria,1MW74@1224|Proteobacteria,2TSFH@28211|Alphaproteobacteria,2JRTU@204441|Rhodospirillales	204441|Rhodospirillales	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_394845_1	1000565.METUNv1_03921	8.13e-05	50.1	COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VQ79@28216|Betaproteobacteria	28216|Betaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_277479_1	1151116.Q7S_14400	2.8e-09	65.9	COG2199@1|root,COG3829@1|root,COG3706@2|Bacteria,COG3829@2|Bacteria,1R7HC@1224|Proteobacteria,1RMA9@1236|Gammaproteobacteria,3FGF3@34037|Rahnella	1236|Gammaproteobacteria	T	Diguanylate cyclase	cph2_1	-	2.7.7.65	ko:K11444	ko02020,ko02025,map02020,map02025	M00509	-	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,PAS,PAS_3,PAS_4,Response_reg
k59_923310_1	1232410.KI421425_gene1546	7.62e-81	244.0	COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,42TN7@68525|delta/epsilon subdivisions,2WQK7@28221|Deltaproteobacteria,43TGA@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_923310_2	1232410.KI421425_gene1543	5.71e-51	173.0	COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,42XJ0@68525|delta/epsilon subdivisions,2WT3A@28221|Deltaproteobacteria,43SUP@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
k59_1730285_1	1304865.JAGF01000001_gene2968	3.03e-141	406.0	COG3285@1|root,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase LigD polymerase domain	ligD	GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
k59_1140272_1	1187848.AJYQ01000008_gene535	6.85e-78	243.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,1RQ31@1236|Gammaproteobacteria,1XV2J@135623|Vibrionales	135623|Vibrionales	E	COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_1140272_2	1187848.AJYQ01000008_gene535	2.7e-08	55.1	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,1RQ31@1236|Gammaproteobacteria,1XV2J@135623|Vibrionales	135623|Vibrionales	E	COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_497710_1	504472.Slin_4614	5.07e-42	157.0	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47MUE@768503|Cytophagia	976|Bacteroidetes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1093691_1	246197.MXAN_3143	7.73e-71	244.0	COG4630@1|root,COG4631@1|root,COG4630@2|Bacteria,COG4631@2|Bacteria,1NQSR@1224|Proteobacteria,43C3C@68525|delta/epsilon subdivisions,2X7DZ@28221|Deltaproteobacteria,2YWS9@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	xdhB	-	1.17.1.4	ko:K13482	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
k59_1672874_1	396588.Tgr7_3004	1.75e-38	136.0	COG1999@1|root,COG1999@2|Bacteria	2|Bacteria	M	signal sequence binding	VVA1110	-	-	-	-	-	-	-	-	-	-	-	-
k59_1672874_2	396588.Tgr7_3005	0.000193	43.5	COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,1S8S0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	SURF1-like protein	surf1	-	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
k59_277490_1	987059.RBXJA2T_12022	1.96e-66	213.0	COG1075@1|root,COG1075@2|Bacteria,1NJNA@1224|Proteobacteria,2VPNT@28216|Betaproteobacteria,1KNTZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,PGAP1
k59_1437937_1	1122179.KB890424_gene3612	5.13e-39	145.0	COG1819@1|root,COG1819@2|Bacteria,4NS6U@976|Bacteroidetes	976|Bacteroidetes	CG	UDP-glucoronosyl and UDP-glucosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	UDPGT
k59_1377821_1	396588.Tgr7_1069	7.16e-77	239.0	COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,1RN94@1236|Gammaproteobacteria,1WXKU@135613|Chromatiales	135613|Chromatiales	S	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
k59_1437939_1	765912.Thimo_2446	3.18e-68	228.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales	135613|Chromatiales	D	DNA segregation ATPase FtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_101419_1	367299.JOEE01000003_gene2824	7.56e-194	548.0	COG1140@1|root,COG1140@2|Bacteria,2GJ8P@201174|Actinobacteria,4FFT8@85021|Intrasporangiaceae	201174|Actinobacteria	C	the beta subunit is an iron sulfur cluster containing electron transfer subunit	narH	-	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Fer4_11,Nitr_red_bet_C
k59_101419_2	1043205.AFYF01000021_gene829	1.51e-19	86.7	COG5013@1|root,COG5013@2|Bacteria,2GKZU@201174|Actinobacteria,4FF95@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narZ	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding
k59_1502367_1	1286106.MPL1_08743	1.02e-128	398.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMA7@1236|Gammaproteobacteria,4601R@72273|Thiotrichales	72273|Thiotrichales	E	TIGRFAM aminopeptidase N, Escherichia coli type	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
k59_556269_2	525244.HMPREF0023_0616	2.9e-98	317.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,3NJ1H@468|Moraxellaceae	1236|Gammaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_850019_1	700508.D174_07375	9.93e-28	109.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,236DQ@1762|Mycobacteriaceae	201174|Actinobacteria	E	alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1021723_1	1509405.GV67_05220	4.31e-10	60.8	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2TS2T@28211|Alphaproteobacteria,4B9B2@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_1021723_2	314231.FP2506_16994	4.04e-54	172.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,2U756@28211|Alphaproteobacteria,2PJNP@255475|Aurantimonadaceae	28211|Alphaproteobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0065003,GO:0070925,GO:0071826,GO:0071840	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
k59_1334605_1	1313172.YM304_21380	2.15e-60	208.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4CMR0@84992|Acidimicrobiia	84992|Acidimicrobiia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A
k59_1862914_1	1286106.MPL1_09130	3.11e-81	250.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,45ZXK@72273|Thiotrichales	72273|Thiotrichales	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_1021727_1	65393.PCC7424_1640	1.52e-62	210.0	COG0659@1|root,COG2066@1|root,COG0659@2|Bacteria,COG2066@2|Bacteria,1G1IK@1117|Cyanobacteria,3KH5H@43988|Cyanothece	1117|Cyanobacteria	E	Belongs to the glutaminase family	glsA	-	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Glutaminase,STAS,cNMP_binding
k59_1672888_1	590998.Celf_3720	7.45e-24	103.0	COG0685@1|root,COG0685@2|Bacteria,2GJTN@201174|Actinobacteria,4F0YM@85016|Cellulomonadaceae	201174|Actinobacteria	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
k59_923354_1	105559.Nwat_0935	3.36e-16	84.0	COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1WXKG@135613|Chromatiales	135613|Chromatiales	DM	mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM,MscS_porin
k59_44480_1	1231190.NA8A_18497	8.93e-95	299.0	COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria,43H44@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_982441_1	935839.JAGJ01000020_gene79	2.74e-81	253.0	COG0566@1|root,COG0566@2|Bacteria,2GJMR@201174|Actinobacteria,4F430@85017|Promicromonosporaceae	201174|Actinobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	rlmB	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
k59_1862940_1	379731.PST_2949	9.88e-94	290.0	COG2509@1|root,COG2509@2|Bacteria,1MV6P@1224|Proteobacteria,1RPTW@1236|Gammaproteobacteria,1YZSV@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	FAD-dependent	IV02_08645	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	Amino_oxidase
k59_321892_1	247490.KSU1_C0781	7.51e-112	342.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_1730335_1	296591.Bpro_5331	7.22e-63	206.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2W02U@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_1267979_1	644282.Deba_0741	8.47e-14	68.9	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,42NNS@68525|delta/epsilon subdivisions,2WMS3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_1267979_2	936550.HMPREF1492_0794	5.64e-19	84.7	COG0528@1|root,COG0528@2|Bacteria,2GKWQ@201174|Actinobacteria,4CUD7@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_1611960_1	1123229.AUBC01000015_gene4659	3.65e-10	66.6	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K64C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Putative Ig domain	-	-	-	-	-	-	-	-	-	-	-	-	HCBP_related,He_PIG,HemolysinCabind
k59_674287_1	1249627.D779_4162	5.41e-112	337.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1WX2I@135613|Chromatiales	135613|Chromatiales	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
k59_204599_1	1336233.JAEH01000031_gene225	2.42e-21	90.1	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,2Q8X8@267890|Shewanellaceae	1236|Gammaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363,GO:1901576	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_204599_2	1283300.ATXB01000001_gene1274	9.86e-35	132.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1XDT5@135618|Methylococcales	135618|Methylococcales	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_1862960_1	861299.J421_1721	1.18e-14	79.3	COG0577@1|root,COG0577@2|Bacteria	861299.J421_1721|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_44521_1	1266909.AUAG01000028_gene1645	7.76e-113	358.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon
k59_674298_1	570967.JMLV01000009_gene1014	3.58e-82	259.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2JQ4Z@204441|Rhodospirillales	204441|Rhodospirillales	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K13896	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	ABC_tran,oligo_HPY
k59_1787594_1	113395.AXAI01000013_gene6862	2.44e-24	109.0	COG2114@1|root,COG3899@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,COG3903@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
k59_1093753_1	29875.EHK22805	1.55e-29	124.0	KOG3378@1|root,KOG3378@2759|Eukaryota,39SRH@33154|Opisthokonta,3NWBB@4751|Fungi,3QPQU@4890|Ascomycota,216V3@147550|Sordariomycetes,3TH42@5125|Hypocreales,3TZYC@5129|Hypocreaceae	4751|Fungi	C	Globin	-	-	1.14.12.17	ko:K05916	ko05132,map05132	-	-	-	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Globin,NAD_binding_1
k59_101515_1	765912.Thimo_0108	6.01e-148	426.0	COG3608@1|root,COG3608@2|Bacteria,1R784@1224|Proteobacteria,1RRY6@1236|Gammaproteobacteria,1WWYR@135613|Chromatiales	135613|Chromatiales	S	PFAM Succinylglutamate desuccinylase Aspartoacylase	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
k59_1672948_1	1121405.dsmv_1660	8.55e-59	190.0	COG2010@1|root,COG2993@1|root,COG2010@2|Bacteria,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,42NZG@68525|delta/epsilon subdivisions,2WNX9@28221|Deltaproteobacteria,2MKZC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	cytochrome C oxidase mono-heme subunit FixO	-	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixO
k59_1672948_2	1121405.dsmv_1661	1.06e-73	234.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,42M5M@68525|delta/epsilon subdivisions,2WM27@28221|Deltaproteobacteria,2MJRK@213118|Desulfobacterales	28221|Deltaproteobacteria	C	cytochrome c oxidase	ccoN	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_850090_2	519989.ECTPHS_13962	2.46e-35	125.0	2CIH3@1|root,32KXU@2|Bacteria,1RJBB@1224|Proteobacteria,1S7QK@1236|Gammaproteobacteria,1X0SX@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1502437_1	1380347.JNII01000005_gene3257	2.23e-51	169.0	COG1414@1|root,COG1414@2|Bacteria,2GNHA@201174|Actinobacteria,4ESUU@85013|Frankiales	201174|Actinobacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	ko:K02624	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
k59_1502437_2	1146883.BLASA_2972	1.51e-32	125.0	COG0402@1|root,COG0402@2|Bacteria,2GNUN@201174|Actinobacteria,4ESKE@85013|Frankiales	201174|Actinobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_101531_1	243231.GSU2969	1.3e-52	177.0	COG2199@1|root,COG3706@2|Bacteria,1RAKG@1224|Proteobacteria,42QYD@68525|delta/epsilon subdivisions,2WN6A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_9
k59_1864351_1	768671.ThimaDRAFT_3697	2.61e-54	183.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,1RMCR@1236|Gammaproteobacteria,1WXCQ@135613|Chromatiales	135613|Chromatiales	P	PFAM NnrS family protein	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
k59_1554626_1	1286170.RORB6_14390	1.82e-54	191.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	general secretion pathway protein	gspF	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
k59_498562_1	1121405.dsmv_1458	4.14e-129	383.0	COG4799@1|root,COG4799@2|Bacteria,1Q9BU@1224|Proteobacteria,42P34@68525|delta/epsilon subdivisions,2WK9S@28221|Deltaproteobacteria,2MI0B@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Carboxyl transferase domain	gcdA	-	4.1.1.70	ko:K01615	ko00362,ko00650,ko01120,map00362,map00650,map01120	-	R03028	RC00832	ko00000,ko00001,ko01000,ko02000	3.B.1.1.3	-	-	Carboxyl_trans
k59_675169_1	765912.Thimo_2397	9.43e-39	146.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1WX60@135613|Chromatiales	135613|Chromatiales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_1378744_2	471853.Bcav_1858	1.04e-184	518.0	COG0320@1|root,COG0320@2|Bacteria,2GKD4@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_850872_2	1249627.D779_4058	2.98e-28	105.0	2BRPS@1|root,32KPD@2|Bacteria,1PAWY@1224|Proteobacteria,1STPX@1236|Gammaproteobacteria,1X1Q8@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1673748_1	1168034.FH5T_09955	3.62e-105	337.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,4NFKH@976|Bacteroidetes,2FNH9@200643|Bacteroidia	976|Bacteroidetes	E	Glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_557138_1	2340.JV46_23670	1.93e-50	174.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1J4GC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	iECSE_1348.ECSE_3895,iJN746.PP_5056	Metalloenzyme,Phosphodiest,iPGM_N
k59_1141020_1	1267005.KB911255_gene2421	5.68e-76	231.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,2TS9Y@28211|Alphaproteobacteria,3N68B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_1378763_1	617140.AJZE01000072_gene811	2.91e-91	285.0	COG2985@1|root,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,1RQ47@1236|Gammaproteobacteria,1XWS1@135623|Vibrionales	135623|Vibrionales	U	Predicted Permease Membrane Region	-	-	-	-	-	-	-	-	-	-	-	-	Asp-Al_Ex
k59_146922_2	1094980.Mpsy_0084	5.61e-65	218.0	COG0531@1|root,arCOG00009@2157|Archaea	2157|Archaea	E	amino acid	-	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1902475,GO:1903825,GO:1905039	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_787608_1	1121106.JQKB01000011_gene368	6.35e-31	113.0	COG1380@1|root,COG1380@2|Bacteria,1N753@1224|Proteobacteria,2UFFT@28211|Alphaproteobacteria,2JU18@204441|Rhodospirillales	204441|Rhodospirillales	S	effector of murein hydrolase LrgA	-	-	-	ko:K06518	-	-	-	-	ko00000,ko02000	1.E.14.2	-	-	LrgA
k59_1731164_2	215803.DB30_2882	1.28e-89	275.0	COG0667@1|root,COG0667@2|Bacteria,1PDY4@1224|Proteobacteria,437WI@68525|delta/epsilon subdivisions,2X366@28221|Deltaproteobacteria,2YUGI@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1731164_3	289376.THEYE_A0081	1.39e-32	126.0	COG0296@1|root,COG0296@2|Bacteria,3J0WY@40117|Nitrospirae	40117|Nitrospirae	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_102873_1	1123501.KB902278_gene713	3.01e-28	112.0	COG0829@1|root,COG0829@2|Bacteria,1RABD@1224|Proteobacteria,2U57R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureD	-	-	ko:K03190	-	-	-	-	ko00000	-	-	-	UreD
k59_924842_1	693986.MOC_4824	7.04e-57	190.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,2TSPP@28211|Alphaproteobacteria,1JS0Z@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
k59_45516_2	666681.M301_1132	4.35e-81	246.0	COG0778@1|root,COG0778@2|Bacteria,1RBZQ@1224|Proteobacteria,2VS22@28216|Betaproteobacteria,2KM8J@206350|Nitrosomonadales	206350|Nitrosomonadales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_1612859_1	367299.JOEE01000004_gene1213	1.9e-89	276.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4FESA@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_924851_1	1379698.RBG1_1C00001G0797	9.83e-57	197.0	COG4191@1|root,COG4191@2|Bacteria,2NS4C@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg
k59_787617_1	1382306.JNIM01000001_gene3087	4.1e-46	159.0	COG1071@1|root,COG1071@2|Bacteria,2G5PA@200795|Chloroflexi	200795|Chloroflexi	C	Dehydrogenase E1 component	-	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
k59_680359_1	1297569.MESS2_p100001	6.16e-60	206.0	COG1181@1|root,COG1181@2|Bacteria,1R4RC@1224|Proteobacteria,2U0HF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
k59_680359_2	1210884.HG799464_gene11229	3.08e-08	60.1	COG0500@1|root,COG2226@2|Bacteria,2IYB6@203682|Planctomycetes	203682|Planctomycetes	Q	Methylase involved in ubiquinone menaquinone	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_1344131_1	1167006.UWK_01424	1.14e-72	233.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2WJJ8@28221|Deltaproteobacteria,2MI9P@213118|Desulfobacterales	28221|Deltaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
k59_1559811_1	1049564.TevJSym_ar00090	7.44e-91	277.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1J5D5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1559811_2	1249627.D779_2217	5.69e-59	190.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,1WXGF@135613|Chromatiales	135613|Chromatiales	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_52481_1	1172188.KB911822_gene1152	1.33e-23	97.1	COG4221@1|root,COG4221@2|Bacteria,2GP05@201174|Actinobacteria,4FFK5@85021|Intrasporangiaceae	201174|Actinobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_52481_2	1172188.KB911822_gene1153	4.25e-125	362.0	COG0395@1|root,COG0395@2|Bacteria,2GN84@201174|Actinobacteria,4FGC8@85021|Intrasporangiaceae	201174|Actinobacteria	P	Mannitol ABC transporter permease	-	-	-	ko:K10229	ko02010,map02010	M00200	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.5	-	-	BPD_transp_1
k59_1274507_1	1267535.KB906767_gene1214	5.01e-43	155.0	COG2433@1|root,COG2433@2|Bacteria,3Y7F1@57723|Acidobacteria	57723|Acidobacteria	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
k59_562056_1	105559.Nwat_2763	3.77e-87	270.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,1RNKP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	PFAM peptidase	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
k59_152122_1	1070319.CAGGBEG34_20025	1.17e-123	366.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VI6I@28216|Betaproteobacteria,1K0WZ@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817	2.3.1.179	ko:K00646,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1678804_1	1122603.ATVI01000009_gene2592	6.82e-32	127.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1X3A5@135614|Xanthomonadales	135614|Xanthomonadales	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
k59_738985_1	340177.Cag_1587	3.83e-33	125.0	COG2046@1|root,COG2046@2|Bacteria,1FF05@1090|Chlorobi	1090|Chlorobi	F	sulfate assimilation	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
k59_285261_1	118173.KB235910_gene4661	4.26e-26	99.8	COG2963@1|root,COG2963@2|Bacteria,1GA7D@1117|Cyanobacteria,1HGED@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_285261_2	765912.Thimo_0912	8.79e-28	109.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,1RXYF@1236|Gammaproteobacteria,1WX0Z@135613|Chromatiales	135613|Chromatiales	L	PFAM integrase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve
k59_404331_1	1089552.KI911559_gene2017	1.02e-35	123.0	COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,2JT7W@204441|Rhodospirillales	204441|Rhodospirillales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_327817_1	323098.Nwi_1973	5.87e-95	283.0	COG0265@1|root,COG0265@2|Bacteria,1R40X@1224|Proteobacteria,2UEZS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
k59_211383_1	765912.Thimo_0167	1.9e-106	328.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,1X257@135613|Chromatiales	135613|Chromatiales	P	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
k59_445743_1	246200.SPO3036	3.34e-73	239.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria,4ND2Q@97050|Ruegeria	28211|Alphaproteobacteria	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_1618873_1	590998.Celf_2125	2.56e-168	483.0	COG0349@1|root,COG0349@2|Bacteria,2GKNM@201174|Actinobacteria,4F0HA@85016|Cellulomonadaceae	201174|Actinobacteria	L	3'-5' exonuclease	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
k59_1384882_1	446466.Cfla_2290	5.56e-53	172.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,4F2GA@85016|Cellulomonadaceae	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1384882_2	446469.Sked_11300	1.28e-67	214.0	COG0266@1|root,COG0266@2|Bacteria,2GJNT@201174|Actinobacteria	201174|Actinobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	GO:0000702,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034039,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_1737021_1	991905.SL003B_3848	1.5e-29	114.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,2VFQ6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	leucine-zipper of insertion element IS481	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve
k59_1737021_2	991905.SL003B_3848	3.31e-55	181.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,2VFQ6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	leucine-zipper of insertion element IS481	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve
k59_286591_1	387093.SUN_0903	1.76e-46	168.0	COG2985@1|root,COG3273@1|root,COG2985@2|Bacteria,COG3273@2|Bacteria,1MUVM@1224|Proteobacteria,42P36@68525|delta/epsilon subdivisions,2YPIH@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	U	YidE YbjL	-	-	-	ko:K07085	-	-	-	-	ko00000	2.A.81	-	-	Asp-Al_Ex,TrkA_C
k59_53730_1	1121035.AUCH01000013_gene3091	6.25e-84	263.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,2VJT0@28216|Betaproteobacteria,2KVAX@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hoxH	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
k59_1679616_1	1298593.TOL_2111	1.63e-76	246.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1XHYU@135619|Oceanospirillales	135619|Oceanospirillales	G	Alpha amylase, catalytic domain	-	-	2.4.1.7	ko:K00690	ko00500,map00500	-	R00803	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_1737026_1	1122134.KB893650_gene31	3.07e-128	374.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,1RX6Z@1236|Gammaproteobacteria,1XRR2@135619|Oceanospirillales	135619|Oceanospirillales	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_405635_1	998674.ATTE01000001_gene584	2.97e-07	50.1	COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,1S263@1236|Gammaproteobacteria,460M2@72273|Thiotrichales	72273|Thiotrichales	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	tpx	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
k59_405635_2	2340.JV46_21420	4.01e-137	401.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1J9E0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI39_1322.ECIAI39_3318	GDC-P
k59_562942_1	1121859.KB890738_gene3493	6.97e-06	53.1	COG3015@1|root,COG3187@1|root,COG3650@1|root,COG3015@2|Bacteria,COG3187@2|Bacteria,COG3650@2|Bacteria,4NN1R@976|Bacteroidetes,47R9J@768503|Cytophagia	976|Bacteroidetes	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META,NlpE
k59_1679627_1	471853.Bcav_2570	4.6e-16	83.6	COG1403@1|root,COG1403@2|Bacteria,2GP2N@201174|Actinobacteria	201174|Actinobacteria	V	HNH endonuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_1679629_1	1163617.SCD_n01728	8.65e-37	135.0	COG0727@1|root,COG0727@2|Bacteria,1R3YG@1224|Proteobacteria,2W1RG@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_681283_1	670307.HYPDE_29508	1.15e-64	211.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2VDGB@28211|Alphaproteobacteria,3N7P3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_1345487_1	240016.ABIZ01000001_gene4298	9.66e-129	372.0	COG1116@1|root,COG1116@2|Bacteria,46UJC@74201|Verrucomicrobia,2ITHC@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_1027716_1	1439940.BAY1663_02861	3.47e-44	164.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_9,Reg_prop,Y_Y_Y
k59_1100997_1	1229485.AMYV01000049_gene3009	3.37e-90	286.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1J4RW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA helicase	uvrD	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0042802,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_328728_1	552811.Dehly_0727	1.29e-52	175.0	COG1941@1|root,COG1941@2|Bacteria,2G6MH@200795|Chloroflexi,34D3J@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
k59_328728_2	1121403.AUCV01000029_gene2713	2.91e-75	238.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,42N63@68525|delta/epsilon subdivisions,2WJPA@28221|Deltaproteobacteria,2MHPB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM nickel-dependent hydrogenase large subunit	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_1444636_1	717785.HYPMC_2890	5.09e-94	276.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2TRFE@28211|Alphaproteobacteria,3N6JA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3,1.6.99.3	ko:K00338,ko:K03941	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6	-	-	Fer4
k59_993189_2	870187.Thini_2252	2.97e-90	280.0	COG0312@1|root,COG0312@2|Bacteria,1QM7I@1224|Proteobacteria,1RSF3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Zn-dependent	tldE2	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
k59_286640_1	1128421.JAGA01000003_gene3022	7.55e-10	65.9	COG1306@1|root,COG1306@2|Bacteria,2NQXI@2323|unclassified Bacteria	2|Bacteria	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
k59_53779_1	1267005.KB911255_gene2501	1.25e-85	261.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TS33@28211|Alphaproteobacteria,3N80V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Cysteine synthase	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1384920_1	356851.JOAN01000014_gene1992	1.05e-57	200.0	2EXNC@1|root,33QY3@2|Bacteria,2ITB7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_445788_1	765910.MARPU_03910	1.19e-63	204.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,1WX3R@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
k59_445788_2	572477.Alvin_0565	1.37e-81	249.0	COG4659@1|root,COG4659@2|Bacteria,1RDEP@1224|Proteobacteria,1RPAD@1236|Gammaproteobacteria,1WVYN@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
k59_792382_1	572477.Alvin_2538	4.65e-12	64.7	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1WVZH@135613|Chromatiales	135613|Chromatiales	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
k59_792382_2	765913.ThidrDRAFT_1703	7.25e-52	167.0	2DX2X@1|root,32V2M@2|Bacteria,1MZZC@1224|Proteobacteria,1S4WN@1236|Gammaproteobacteria,1WYAX@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1027761_1	243274.THEMA_05480	5.96e-05	45.8	COG2730@1|root,COG2730@2|Bacteria,2GDQI@200918|Thermotogae	200918|Thermotogae	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Cellulase
k59_1027761_2	497964.CfE428DRAFT_4347	2.99e-33	119.0	COG2514@1|root,COG2514@2|Bacteria,46SQP@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
k59_1345529_1	983917.RGE_15240	7.26e-97	298.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2VHHD@28216|Betaproteobacteria,1KJ5Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	TRAP dicarboxylate transporter, DctM subunit	-	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	DctM
k59_1618925_1	768671.ThimaDRAFT_2883	1.83e-87	274.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,1WW19@135613|Chromatiales	135613|Chromatiales	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_1027764_1	990285.RGCCGE502_13244	3.38e-23	97.1	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2TT2F@28211|Alphaproteobacteria,4B7ZP@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	NADH flavin oxidoreductases, Old Yellow Enzyme family	nemA	GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0044464,GO:0055114	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
k59_1027764_2	998674.ATTE01000001_gene2448	1.67e-15	78.2	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,1RPJA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2189
k59_405700_1	880072.Desac_1973	1.15e-32	122.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,42N9Q@68525|delta/epsilon subdivisions,2WIK1@28221|Deltaproteobacteria,2MRGN@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_405700_2	880072.Desac_1974	3.94e-29	114.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,42N4P@68525|delta/epsilon subdivisions,2WJ0B@28221|Deltaproteobacteria,2MQ7I@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_1384937_1	1156919.QWC_27931	2.06e-06	50.1	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,3T2KK@506|Alcaligenaceae	28216|Betaproteobacteria	F	dGTPase family. Type 2 subfamily	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_1384937_2	765912.Thimo_0089	5.53e-49	167.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1WWZW@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_1509876_1	1385518.N798_08505	9.41e-112	331.0	COG0505@1|root,COG0505@2|Bacteria,2GKFA@201174|Actinobacteria,4FFSI@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the CarA family	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1383	CPSase_sm_chain,GATase
k59_286680_1	439235.Dalk_2572	2.7e-111	336.0	COG1032@1|root,COG1032@2|Bacteria,1R4XI@1224|Proteobacteria,42NPM@68525|delta/epsilon subdivisions,2WJK2@28221|Deltaproteobacteria,2MI65@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_933984_1	1500301.JQMF01000028_gene2810	2.65e-17	84.7	COG0583@1|root,COG0583@2|Bacteria,1MVJ7@1224|Proteobacteria,2TT9Z@28211|Alphaproteobacteria,4BD9J@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_211446_1	765912.Thimo_3548	2.57e-18	88.2	2CB8R@1|root,2Z90U@2|Bacteria,1R4DV@1224|Proteobacteria,1RPSZ@1236|Gammaproteobacteria,1WZX3@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1737076_1	526226.Gbro_2319	1.39e-18	85.5	COG2256@1|root,COG2256@2|Bacteria,2GKDP@201174|Actinobacteria,4GCCI@85026|Gordoniaceae	201174|Actinobacteria	L	MgsA AAA+ ATPase C terminal	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_153066_1	96561.Dole_2033	9.55e-119	345.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,42MW0@68525|delta/epsilon subdivisions,2WJ90@28221|Deltaproteobacteria,2MHRX@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
k59_153066_2	218284.CCDN010000002_gene2004	0.000114	43.5	COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,4H9YD@91061|Bacilli,1ZBHP@1386|Bacillus	91061|Bacilli	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU11190	Semialdhyde_dh,Semialdhyde_dhC
k59_1146308_1	215803.DB30_6413	7.2e-51	173.0	COG0189@1|root,COG0189@2|Bacteria,1MV29@1224|Proteobacteria,42VTI@68525|delta/epsilon subdivisions,2WW2V@28221|Deltaproteobacteria,2YYXY@29|Myxococcales	28221|Deltaproteobacteria	HJ	COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	GSH-S_ATP
k59_1209467_1	1123054.KB907701_gene1845	1.24e-23	105.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1WW36@135613|Chromatiales	135613|Chromatiales	E	PFAM NAD-glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
k59_405719_1	765911.Thivi_3574	3.33e-121	363.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1WWTY@135613|Chromatiales	135613|Chromatiales	FP	Belongs to the GppA Ppx family	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_211452_1	1121015.N789_05665	1.47e-86	266.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1X3ZA@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
k59_1027797_1	583355.Caka_2562	5.15e-53	183.0	COG0004@1|root,COG0004@2|Bacteria,46SCE@74201|Verrucomicrobia,3K7NK@414999|Opitutae	74201|Verrucomicrobia	P	ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_53834_1	452637.Oter_0670	1.18e-17	82.0	COG1053@1|root,COG1053@2|Bacteria,46S7D@74201|Verrucomicrobia,3K754@414999|Opitutae	414999|Opitutae	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_53834_2	316274.Haur_1734	1.05e-43	153.0	2CAZH@1|root,2Z7RU@2|Bacteria,2G8SJ@200795|Chloroflexi,375P9@32061|Chloroflexia	32061|Chloroflexia	C	TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_1618943_1	697282.Mettu_3282	2.02e-217	609.0	COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,1RQHX@1236|Gammaproteobacteria,1XEVC@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4478)	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DUF3412,DUF4478,Lysine_decarbox
k59_1209468_2	1304872.JAGC01000009_gene1532	6.65e-65	221.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,42PRE@68525|delta/epsilon subdivisions,2WJRD@28221|Deltaproteobacteria,2MAAB@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_792401_1	105559.Nwat_1735	3.83e-27	107.0	COG0265@1|root,COG0265@2|Bacteria,1R9ZV@1224|Proteobacteria,1S2AZ@1236|Gammaproteobacteria,1X064@135613|Chromatiales	135613|Chromatiales	O	peptidase S1 and S6, chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
k59_856731_1	1260251.SPISAL_01215	7.22e-29	114.0	COG3087@1|root,COG3087@2|Bacteria,1MYFG@1224|Proteobacteria,1SD3J@1236|Gammaproteobacteria,1WYSZ@135613|Chromatiales	135613|Chromatiales	D	PFAM Sporulation	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
k59_934015_1	926550.CLDAP_03380	8.23e-45	164.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria,2G825@200795|Chloroflexi	200795|Chloroflexi	CO	Cytochrome C biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_405739_1	247490.KSU1_C0162	5.25e-13	72.0	COG1040@1|root,COG1040@2|Bacteria,2J03E@203682|Planctomycetes	203682|Planctomycetes	S	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
k59_1689617_1	1082933.MEA186_30901	9.26e-40	152.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_1570429_2	1122222.AXWR01000018_gene2614	1.92e-19	84.3	COG0607@1|root,COG0607@2|Bacteria,1WJYP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	COG0607 Rhodanese-related sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_799811_1	551275.KB899544_gene894	1.77e-12	68.6	COG3474@1|root,COG3474@2|Bacteria,1MZGS@1224|Proteobacteria,2UCUT@28211|Alphaproteobacteria,43YHJ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	Cytochrome c	-	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0015979,GO:0016020,GO:0044237,GO:0044464,GO:0071944	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
k59_866948_1	1713.JOFV01000004_gene3316	4.51e-92	277.0	COG0566@1|root,COG0566@2|Bacteria,2GJI6@201174|Actinobacteria,4F0NU@85016|Cellulomonadaceae	201174|Actinobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	tsnR	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
k59_455219_1	452637.Oter_3715	9.29e-44	152.0	COG3132@1|root,COG3132@2|Bacteria,46VIH@74201|Verrucomicrobia,3K85I@414999|Opitutae	414999|Opitutae	S	Belongs to the UPF0502 family	-	-	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480
k59_1521230_1	1120971.AUCA01000078_gene1866	1.3e-18	87.4	COG4974@1|root,COG4974@2|Bacteria,1TQ3R@1239|Firmicutes,4HD6N@91061|Bacilli,278SR@186823|Alicyclobacillaceae	91061|Bacilli	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_220922_1	1121405.dsmv_0433	3.98e-71	231.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42ME4@68525|delta/epsilon subdivisions,2WJA5@28221|Deltaproteobacteria,2MIGA@213118|Desulfobacterales	28221|Deltaproteobacteria	T	CheY-like receiver, AAA-type ATPase, and DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1038861_1	754477.Q7C_863	1.74e-89	273.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,46072@72273|Thiotrichales	72273|Thiotrichales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_799831_1	765913.ThidrDRAFT_3296	6.86e-67	224.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1WWE3@135613|Chromatiales	135613|Chromatiales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1219426_1	519989.ECTPHS_00530	2.74e-106	322.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1WWU2@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_749755_1	981384.AEYW01000025_gene4043	2.66e-36	132.0	COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2TQWN@28211|Alphaproteobacteria,4NACW@97050|Ruegeria	28211|Alphaproteobacteria	S	Cobalamin biosynthesis protein CobW	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
k59_1287185_1	1121405.dsmv_0917	1.6e-77	240.0	COG0697@1|root,COG0697@2|Bacteria,1PIF3@1224|Proteobacteria,42SMV@68525|delta/epsilon subdivisions,2WPAJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_690787_1	1499967.BAYZ01000138_gene184	9.16e-46	155.0	28IMV@1|root,2Z8NA@2|Bacteria	2|Bacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_866978_1	335543.Sfum_3468	6.62e-57	194.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,42MJY@68525|delta/epsilon subdivisions,2WJAQ@28221|Deltaproteobacteria,2MQ6S@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	AlaDh_PNT_C,FAD_binding_3,Mur_ligase_C,Mur_ligase_M,NAD_binding_8
k59_749756_1	933262.AXAM01000001_gene334	5.22e-103	323.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MIJD@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_631521_1	367299.JOEE01000001_gene2062	4.08e-88	268.0	COG0142@1|root,COG0142@2|Bacteria,2GMB4@201174|Actinobacteria,4FE3E@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	hepT	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_631521_2	367299.JOEE01000001_gene2061	1.09e-78	249.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4FF3X@85021|Intrasporangiaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1521262_1	1278307.KB907057_gene2644	4.88e-24	99.8	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,2QJ5B@267894|Psychromonadaceae	1236|Gammaproteobacteria	L	COG3547 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1570479_1	1247726.MIM_c08690	4.65e-13	68.9	COG0687@1|root,COG0687@2|Bacteria,1MWG5@1224|Proteobacteria,2VI27@28216|Betaproteobacteria,3T3BE@506|Alcaligenaceae	28216|Betaproteobacteria	P	COG0687 Spermidine putrescine-binding periplasmic protein	potD	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_6,SBP_bac_8
k59_1570479_2	994573.T472_0203175	3.87e-14	72.8	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,36EAA@31979|Clostridiaceae	186801|Clostridia	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.30,3.6.3.31	ko:K02010,ko:K02052,ko:K11072	ko02010,ko02024,map02010,map02024	M00190,M00193,M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11,3.A.1.11.1	-	-	ABC_tran,TOBE_2
k59_1689668_2	1458357.BG58_26575	6.62e-85	266.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2VHZF@28216|Betaproteobacteria,1K2HK@119060|Burkholderiaceae	28216|Betaproteobacteria	E	serine acetyltransferase	srpH	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
k59_1689668_3	857571.EA1_08662	2.38e-18	84.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,3NJTJ@468|Moraxellaceae	1236|Gammaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009333,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2414,iAPECO1_1312.APECO1_4131,iB21_1397.B21_02275,iBWG_1329.BWG_2176,iE2348C_1286.E2348C_2600,iEC042_1314.EC042_2623,iEC55989_1330.EC55989_2704,iECABU_c1320.ECABU_c27350,iECBD_1354.ECBD_1267,iECB_1328.ECB_02314,iECDH10B_1368.ECDH10B_2579,iECDH1ME8569_1439.ECDH1ME8569_2348,iECD_1391.ECD_02314,iECED1_1282.ECED1_2858,iECH74115_1262.ECH74115_3645,iECIAI1_1343.ECIAI1_2472,iECNA114_1301.ECNA114_2491,iECO103_1326.ECO103_2933,iECO111_1330.ECO111_3144,iECO26_1355.ECO26_3467,iECOK1_1307.ECOK1_2731,iECP_1309.ECP_2438,iECS88_1305.ECS88_2604,iECSE_1348.ECSE_2705,iECSF_1327.ECSF_2278,iECSP_1301.ECSP_3362,iECUMN_1333.ECUMN_2736,iECW_1372.ECW_m2643,iECs_1301.ECs3286,iEKO11_1354.EKO11_1314,iETEC_1333.ETEC_2527,iEcDH1_1363.EcDH1_1247,iEcHS_1320.EcHS_A2549,iEcSMS35_1347.EcSMS35_2569,iEcolC_1368.EcolC_1264,iG2583_1286.G2583_2946,iJO1366.b2414,iJR904.b2414,iLF82_1304.LF82_0418,iNRG857_1313.NRG857_12105,iSSON_1240.SSON_2503,iSbBS512_1146.SbBS512_E2766,iUMN146_1321.UM146_04550,iUMNK88_1353.UMNK88_3016,iUTI89_1310.UTI89_C2747,iWFL_1372.ECW_m2643,iY75_1357.Y75_RS12650,iZ_1308.Z3680	PALP
k59_631536_1	572477.Alvin_2314	4.39e-14	73.2	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,1WW2W@135613|Chromatiales	135613|Chromatiales	P	PFAM sodium hydrogen exchanger	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
k59_513946_1	768671.ThimaDRAFT_0861	3.74e-54	180.0	COG4313@1|root,COG4313@2|Bacteria,1PC95@1224|Proteobacteria,1S8PJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
k59_513946_2	1248916.ANFY01000003_gene936	0.000936	42.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,2K8V1@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_339017_1	349521.HCH_00578	2.15e-18	83.2	COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,1XJA6@135619|Oceanospirillales	135619|Oceanospirillales	O	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host	djlA	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
k59_339017_2	1423790.BN53_00540	8.89e-10	57.4	COG4633@1|root,COG4633@2|Bacteria,1W06G@1239|Firmicutes,4HZAG@91061|Bacilli,3F7FA@33958|Lactobacillaceae	91061|Bacilli	S	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
k59_867002_1	648885.KB316282_gene743	3.12e-117	354.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2UQAG@28211|Alphaproteobacteria,1JRH8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	V	PFAM ABC transporter transmembrane region	atm1	GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006996,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009507,GO:0009526,GO:0009536,GO:0009555,GO:0009657,GO:0009658,GO:0009889,GO:0009941,GO:0009987,GO:0010035,GO:0010038,GO:0010288,GO:0010380,GO:0016020,GO:0016043,GO:0018130,GO:0019222,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0019866,GO:0022622,GO:0030003,GO:0031090,GO:0031323,GO:0031326,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0042221,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046686,GO:0046916,GO:0048229,GO:0048364,GO:0048731,GO:0048856,GO:0048878,GO:0050789,GO:0050790,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051186,GO:0051188,GO:0051189,GO:0051193,GO:0051276,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0071840,GO:0090056,GO:0090407,GO:0098771,GO:0099402,GO:1901360,GO:1901362,GO:1901401,GO:1901463,GO:1901564,GO:1901566,GO:1901576	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1521292_1	926550.CLDAP_00050	3.43e-89	269.0	COG0588@1|root,COG0588@2|Bacteria,2G822@200795|Chloroflexi	200795|Chloroflexi	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmA	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
k59_1801959_1	472759.Nhal_1157	4.6e-179	513.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1WWXH@135613|Chromatiales	135613|Chromatiales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_867020_1	1121405.dsmv_1598	8.56e-37	135.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WJVC@28221|Deltaproteobacteria,2MINJ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
k59_867020_2	1121405.dsmv_1597	5.72e-29	113.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,42M3V@68525|delta/epsilon subdivisions,2WJJ4@28221|Deltaproteobacteria,2MHT5@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_1570512_1	196367.JNFG01000034_gene7553	1.05e-76	233.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,2W5BV@28216|Betaproteobacteria,1K5NQ@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1394469_1	472759.Nhal_0327	1.57e-78	251.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1WWBU@135613|Chromatiales	135613|Chromatiales	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_162807_1	765912.Thimo_3328	3.87e-225	649.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1WWJI@135613|Chromatiales	135613|Chromatiales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_749806_1	1343740.M271_05280	1.08e-60	204.0	COG3299@1|root,COG3299@2|Bacteria,2GM5C@201174|Actinobacteria	201174|Actinobacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
k59_749806_2	1385519.N801_08640	2.89e-71	216.0	COG3628@1|root,COG3628@2|Bacteria,2IFJ6@201174|Actinobacteria,4FI0Z@85021|Intrasporangiaceae	201174|Actinobacteria	S	Gene 25-like lysozyme	-	-	-	ko:K06903	-	-	-	-	ko00000	-	-	-	GPW_gp25
k59_1287247_1	768671.ThimaDRAFT_0838	1.85e-25	97.4	2BRPS@1|root,32KPD@2|Bacteria,1PAWY@1224|Proteobacteria,1STPX@1236|Gammaproteobacteria,1X1Q8@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1454825_1	911239.CF149_21843	8.49e-124	367.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	fleQ	-	-	ko:K10941	ko02020,ko02025,ko05111,map02020,map02025,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	FleQ,HTH_8,Sigma54_activat
k59_455290_2	857087.Metme_2909	3.2e-17	77.8	COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,1S6FG@1236|Gammaproteobacteria,1XF04@135618|Methylococcales	135618|Methylococcales	S	pfam ammecr1	-	-	-	-	-	-	-	-	-	-	-	-	AMMECR1
k59_339072_1	314271.RB2654_09084	1.56e-110	327.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TRRH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	BQ	COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein	aphA	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_1219510_1	926550.CLDAP_25740	6.37e-144	429.0	COG5322@1|root,COG5322@2|Bacteria,2G7SR@200795|Chloroflexi	200795|Chloroflexi	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1114070_1	1278073.MYSTI_01847	6.99e-95	291.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,42Q8I@68525|delta/epsilon subdivisions,2X5IX@28221|Deltaproteobacteria,2YYPK@29|Myxococcales	28221|Deltaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_222248_1	580332.Slit_1678	2.26e-115	349.0	COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria,44V9S@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_21,Fer4_7,Pyr_redox_2,Pyr_redox_3
k59_691958_1	1380393.JHVP01000003_gene1268	2.74e-66	216.0	COG1073@1|root,COG2114@1|root,COG1073@2|Bacteria,COG2114@2|Bacteria,2IASU@201174|Actinobacteria	201174|Actinobacteria	IT	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
k59_691958_2	644076.SCH4B_3579	4.57e-05	49.3	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,2TRS3@28211|Alphaproteobacteria,4NB9B@97050|Ruegeria	28211|Alphaproteobacteria	G	Alpha amylase, catalytic domain	aglA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459,Malt_amylase_C
k59_1220669_1	1267600.JFGT01000004_gene3342	5.04e-25	107.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,3VZ89@53335|Pantoea	1236|Gammaproteobacteria	M	Catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N
k59_1288868_1	572265.HDEF_1180	5.37e-27	102.0	COG3744@1|root,COG3744@2|Bacteria,1N2T0@1224|Proteobacteria,1S7NW@1236|Gammaproteobacteria,283HT@191675|unclassified Enterobacteriaceae	1236|Gammaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
k59_1288868_2	1454010.JEOE01000004_gene94	2.34e-26	98.6	COG4118@1|root,COG4118@2|Bacteria,2GSDT@201174|Actinobacteria	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
k59_1288868_3	446469.Sked_00400	1.51e-13	66.6	COG3744@1|root,COG3744@2|Bacteria,2GS3K@201174|Actinobacteria	201174|Actinobacteria	S	PFAM PilT protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PIN
k59_800703_1	1565314.OA34_10115	1.68e-38	145.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,42NAX@68525|delta/epsilon subdivisions,2YN4X@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_1456029_1	1121403.AUCV01000124_gene2974	4.27e-130	387.0	COG2433@1|root,COG2433@2|Bacteria,1RE5Q@1224|Proteobacteria,42WSA@68525|delta/epsilon subdivisions,2WRPQ@28221|Deltaproteobacteria,2MMJ3@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_340182_1	387631.Asulf_02109	6.63e-42	157.0	COG1148@1|root,COG1908@1|root,arCOG02235@2157|Archaea,arCOG02476@2157|Archaea,2XT3X@28890|Euryarchaeota,245U1@183980|Archaeoglobi	183980|Archaeoglobi	C	Heterodisulfide reductase subunit A and related polyferredoxins	-	-	-	ko:K16886	-	-	-	-	ko00000	-	-	-	Fer4,FlpD,Pyr_redox_2
k59_1522954_1	1121374.KB891587_gene2997	3.25e-18	82.4	COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,1S739@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
k59_1522954_2	396588.Tgr7_0024	2.44e-26	106.0	COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1RNDT@1236|Gammaproteobacteria,1WW02@135613|Chromatiales	135613|Chromatiales	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10,RmlD_sub_bind
k59_1220690_1	1304865.JAGF01000001_gene1857	3.14e-82	263.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4F0IY@85016|Cellulomonadaceae	201174|Actinobacteria	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_691981_1	1464048.JNZS01000033_gene2794	4.2e-84	265.0	COG1075@1|root,COG1075@2|Bacteria,2HXFM@201174|Actinobacteria,4DI5G@85008|Micromonosporales	201174|Actinobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_2
k59_751085_1	189753.AXAS01000102_gene5975	3.89e-112	335.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U1Z0@28211|Alphaproteobacteria,3JW1X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986,ko:K15342	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	Cas_Cas1,GIIM,RVT_1
k59_1220698_1	396588.Tgr7_1568	1.42e-79	263.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWSZ@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1456058_1	338969.Rfer_2419	3.88e-51	173.0	COG1295@1|root,COG1295@2|Bacteria,1NH82@1224|Proteobacteria,2VJW7@28216|Betaproteobacteria,4AAJH@80864|Comamonadaceae	28216|Betaproteobacteria	S	Virulence factor BrkB	-	-	-	-	-	-	-	-	-	-	-	-	Virul_fac_BrkB
k59_456243_1	519989.ECTPHS_10696	2.31e-87	263.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1WX5A@135613|Chromatiales	135613|Chromatiales	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_456243_2	626887.J057_20185	3.24e-28	108.0	COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,1S90K@1236|Gammaproteobacteria,467KB@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	Biopolymer transport protein ExbD/TolR	exbD1	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_1571858_1	497964.CfE428DRAFT_5666	1.01e-72	228.0	COG0040@1|root,COG0040@2|Bacteria,46SHK@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Histidine biosynthesis protein HisG domain	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
k59_1288929_2	234267.Acid_5940	3.67e-20	92.8	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_1748270_1	991905.SL003B_2058	2.97e-94	288.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TSCR@28211|Alphaproteobacteria,4BPWC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	TIGRFAM glutamine synthetase, type I	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_692000_1	690850.Desaf_0477	4.84e-75	241.0	COG2367@1|root,COG2367@2|Bacteria,1R4Y9@1224|Proteobacteria,42YC9@68525|delta/epsilon subdivisions,2WTSH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1156014_1	1463856.JOHY01000009_gene6667	3.91e-18	84.0	COG2013@1|root,COG2013@2|Bacteria,2I9XC@201174|Actinobacteria	201174|Actinobacteria	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
k59_1156014_2	653045.Strvi_2432	3.15e-53	176.0	COG2013@1|root,COG2013@2|Bacteria,2I9XC@201174|Actinobacteria	201174|Actinobacteria	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
k59_1156014_3	590998.Celf_0508	2.64e-13	70.5	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4F0FK@85016|Cellulomonadaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
k59_1040635_2	1161401.ASJA01000002_gene2725	2.14e-07	52.4	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria,43X47@69657|Hyphomonadaceae	28211|Alphaproteobacteria	J	due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1571860_2	768671.ThimaDRAFT_1815	5.41e-94	280.0	COG2259@1|root,COG2259@2|Bacteria,1RBZP@1224|Proteobacteria,1S28E@1236|Gammaproteobacteria,1WYB3@135613|Chromatiales	135613|Chromatiales	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
k59_1571860_3	261292.Nit79A3_3205	2.17e-85	261.0	COG3219@1|root,COG3219@2|Bacteria,1R8C9@1224|Proteobacteria,2VPVN@28216|Betaproteobacteria,372NA@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Putative DNA-binding domain	-	-	-	ko:K09929	-	-	-	-	ko00000	-	-	-	DUF2063
k59_632627_1	497964.CfE428DRAFT_0348	4.16e-36	142.0	COG0612@1|root,COG0612@2|Bacteria,46S9I@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM peptidase M16 domain protein	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_573563_1	2340.JV46_24990	2.05e-75	243.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1J50Y@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0659 Sulfate permease and related transporters (MFS superfamily)	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,STAS_2,Sulfate_transp
k59_1220721_1	743718.Isova_2046	7.01e-87	269.0	COG3464@1|root,COG3464@2|Bacteria,2GJK7@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_222326_1	240016.ABIZ01000001_gene3863	3.88e-51	180.0	COG0188@1|root,COG0188@2|Bacteria,46SBE@74201|Verrucomicrobia,2ITMM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	DNA Topoisomerase IV	-	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_222326_2	1458427.BAWN01000029_gene1694	6.55e-11	62.4	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,4AA3D@80864|Comamonadaceae	28216|Betaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_456266_1	1187851.A33M_1581	6.06e-05	44.3	COG2710@1|root,COG2710@2|Bacteria,1MVP0@1224|Proteobacteria,2TSK1@28211|Alphaproteobacteria,3FDQZ@34008|Rhodovulum	28211|Alphaproteobacteria	C	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex	bchN	-	1.3.7.7	ko:K04038	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06282	RC01008	ko00000,ko00001,ko01000	-	-	-	Oxidored_nitro
k59_456266_2	572477.Alvin_2641	2.09e-98	301.0	COG2710@1|root,COG2710@2|Bacteria,1MWQ4@1224|Proteobacteria,1RQR5@1236|Gammaproteobacteria,1WXMP@135613|Chromatiales	135613|Chromatiales	F	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex	bchB	-	1.3.7.7	ko:K04039	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06282	RC01008	ko00000,ko00001,ko01000	-	-	-	Oxidored_nitro,PCP_red
k59_164168_1	1121405.dsmv_3708	1.07e-22	96.3	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,2MI1E@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
k59_164168_2	96561.Dole_2760	3.91e-29	108.0	COG0664@1|root,COG0664@2|Bacteria,1QHKB@1224|Proteobacteria,42RR8@68525|delta/epsilon subdivisions,2WN8W@28221|Deltaproteobacteria,2MJUH@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_1415606_1	1380391.JIAS01000019_gene1320	2.37e-08	56.2	COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,2UBXV@28211|Alphaproteobacteria,2JSNN@204441|Rhodospirillales	204441|Rhodospirillales	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
k59_1415606_2	580340.Tlie_0775	1.94e-17	81.3	COG1702@1|root,COG1702@2|Bacteria,3T9PX@508458|Synergistetes	508458|Synergistetes	T	PFAM PhoH family protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_593481_1	1035308.AQYY01000001_gene3429	6.98e-94	289.0	COG0029@1|root,COG0029@2|Bacteria,1UHSP@1239|Firmicutes,25E6F@186801|Clostridia,260KQ@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1356541_1	105559.Nwat_2653	2.18e-65	206.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,1RS0S@1236|Gammaproteobacteria,1WWNN@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine	-	-	2.4.2.28,2.4.2.44	ko:K00772,ko:K19696	ko00270,ko01100,map00270,map01100	M00034	R01402,R09668	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
k59_1356541_2	768066.HELO_2708	8.66e-43	146.0	COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,1RNPQ@1236|Gammaproteobacteria,1XJQK@135619|Oceanospirillales	135619|Oceanospirillales	F	Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_1120901_1	1452536.JARE01000063_gene3296	1.4e-23	102.0	COG0647@1|root,COG0647@2|Bacteria,2GK7V@201174|Actinobacteria,4FKYY@85023|Microbacteriaceae	201174|Actinobacteria	G	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
k59_890090_1	1207058.L53_02535	7.56e-05	48.9	29MQ2@1|root,308MT@2|Bacteria,1REUR@1224|Proteobacteria,2UBSM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1829350_1	572477.Alvin_0525	3.75e-90	277.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1WVW0@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1829350_2	243233.MCA1127	2.98e-41	145.0	COG0596@1|root,COG0596@2|Bacteria,1QUBR@1224|Proteobacteria,1RSF9@1236|Gammaproteobacteria,1XF2Y@135618|Methylococcales	135618|Methylococcales	S	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters	bioH	GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.1.85	ko:K02170	ko00780,ko01100,map00780,map01100	M00572	R09725	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
k59_1532483_1	1267533.KB906739_gene2462	1.37e-211	602.0	COG0659@1|root,COG0659@2|Bacteria	2|Bacteria	P	secondary active sulfate transmembrane transporter activity	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_768637_1	322710.Avin_00090	7.81e-17	75.9	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,1S3UD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	D,D-heptose 1,7-bisphosphate phosphatase	gmhB	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iJN746.PP_0059	Hydrolase_like
k59_768637_2	1049564.TevJSym_aq00120	1.44e-50	162.0	2F88A@1|root,340MG@2|Bacteria,1NXS1@1224|Proteobacteria,1SQ1P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Phosphoribosyl-ATP pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG
k59_949010_1	335543.Sfum_1202	1.18e-88	283.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MQB9@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1120909_1	1304275.C41B8_12589	7.21e-115	363.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_361814_1	367299.JOEE01000001_gene1610	6.62e-59	200.0	COG2905@1|root,COG2905@2|Bacteria,2I91C@201174|Actinobacteria,4FEXU@85021|Intrasporangiaceae	201174|Actinobacteria	T	Putative nucleotidyltransferase DUF294	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_1415625_1	375286.mma_1470	3.26e-58	184.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2VIQP@28216|Betaproteobacteria,472YC@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
k59_1415625_2	946483.Cenrod_1698	6.53e-34	126.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2VHD0@28216|Betaproteobacteria,4A9M0@80864|Comamonadaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_1356550_1	1051632.TPY_0530	1.08e-90	286.0	COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia	186801|Clostridia	L	PFAM transposase, mutator	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_243605_1	713586.KB900536_gene1995	3.18e-67	205.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1WY86@135613|Chromatiales	135613|Chromatiales	K	Belongs to the P(II) protein family	-	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
k59_243605_2	857087.Metme_2937	3.85e-107	321.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1XFEP@135618|Methylococcales	135618|Methylococcales	P	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_1829369_1	765911.Thivi_0099	9.5e-52	173.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1WW2E@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
k59_1829369_2	1049564.TevJSym_ac01070	7.81e-10	55.8	COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,1S66E@1236|Gammaproteobacteria,1J696@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0016485,GO:0016540,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0071704,GO:1901564	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_0139,iYL1228.KPN_00139	Asp_decarbox
k59_361818_1	1035308.AQYY01000002_gene632	2.3e-79	264.0	COG2132@1|root,COG2132@2|Bacteria,1TQSU@1239|Firmicutes,24CJP@186801|Clostridia,260KE@186807|Peptococcaceae	186801|Clostridia	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_417174_1	1049564.TevJSym_aa00430	6.17e-36	141.0	COG4191@1|root,COG5001@1|root,COG4191@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1T5JB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_9807_1	870187.Thini_4359	1.25e-105	324.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,460GF@72273|Thiotrichales	72273|Thiotrichales	L	DNA photolyase	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_710928_1	1453501.JELR01000001_gene2364	1.84e-90	293.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,46425@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Efflux pump	acrB	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_710928_2	1380387.JADM01000007_gene543	0.000415	42.7	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RPI1@1236|Gammaproteobacteria,1XHAQ@135619|Oceanospirillales	135619|Oceanospirillales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD,HlyD_D23
k59_1180611_1	472759.Nhal_3534	1.95e-81	260.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1WXKA@135613|Chromatiales	135613|Chromatiales	G	PFAM Alpha amylase, catalytic	-	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_593503_1	552811.Dehly_1699	5.33e-118	349.0	2CDJ3@1|root,2Z7R6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1240053_1	471853.Bcav_1966	6.56e-66	217.0	COG3919@1|root,COG3919@2|Bacteria,2GM4D@201174|Actinobacteria	201174|Actinobacteria	V	ATP-grasp	-	-	6.3.1.12	ko:K17810	-	-	-	-	ko00000,ko01000	-	-	-	CPSase_L_D2
k59_1650452_2	1306174.JODP01000002_gene5612	7.17e-162	479.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria	201174|Actinobacteria	S	unusual protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
k59_1650452_3	675635.Psed_3137	2.25e-66	216.0	COG2141@1|root,COG2141@2|Bacteria,2GPA5@201174|Actinobacteria,4E2HG@85010|Pseudonocardiales	201174|Actinobacteria	C	F420-dependent oxidoreductase, MSMEG_2906 family	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1829388_1	65497.JODV01000002_gene4192	1.03e-69	217.0	COG0745@1|root,COG0745@2|Bacteria,2GMVN@201174|Actinobacteria,4E0AP@85010|Pseudonocardiales	201174|Actinobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_9832_1	477641.MODMU_5542	1.36e-92	299.0	COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,2GISC@201174|Actinobacteria,4ERN6@85013|Frankiales	201174|Actinobacteria	L	SWIM zinc finger	helZ	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
k59_123938_1	926569.ANT_26710	2.84e-118	347.0	COG1980@1|root,COG1980@2|Bacteria,2G63P@200795|Chloroflexi	200795|Chloroflexi	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
k59_534900_1	1416759.AYMR01000006_gene1204	2.89e-21	97.1	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1003573_1	765420.OSCT_0805	5.22e-20	95.5	COG0577@1|root,COG0577@2|Bacteria,2G65B@200795|Chloroflexi,37660@32061|Chloroflexia	32061|Chloroflexia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_243639_1	472759.Nhal_0095	5.9e-79	250.0	COG0297@1|root,COG0297@2|Bacteria,1P7F2@1224|Proteobacteria,1RZVJ@1236|Gammaproteobacteria,1WX4C@135613|Chromatiales	135613|Chromatiales	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	-	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_361851_1	1337093.MBE-LCI_3776	2.02e-61	201.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TTAW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1301264_1	269799.Gmet_3022	1.54e-26	112.0	COG3383@1|root,COG3383@2|Bacteria,1QW12@1224|Proteobacteria,43BQY@68525|delta/epsilon subdivisions,2X5UH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	sfrA	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944	1.17.1.10	ko:K05299	ko00680,ko00720,ko01100,ko01120,ko01200,map00680,map00720,map01100,map01120,map01200	M00377	R00134	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Fer4_10,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1650457_1	1172188.KB911820_gene3151	3.27e-122	360.0	COG0053@1|root,COG0053@2|Bacteria,2GJ8Q@201174|Actinobacteria,4FE8E@85021|Intrasporangiaceae	201174|Actinobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_1650457_2	710111.FraQA3DRAFT_2931	3.71e-97	309.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,4ES1X@85013|Frankiales	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_890139_2	710111.FraQA3DRAFT_5321	6.01e-93	281.0	COG1802@1|root,COG1802@2|Bacteria,2IDZ6@201174|Actinobacteria,4ET86@85013|Frankiales	201174|Actinobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_123944_1	748280.NH8B_0314	1.36e-27	114.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,2KR1R@206351|Neisseriales	206351|Neisseriales	M	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N,SurA_N_3
k59_68376_1	426117.M446_0082	4.11e-15	80.9	COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,2TW9Z@28211|Alphaproteobacteria,1JTWQ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	V	secretion protein HlyD family	yhiI	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_476111_2	471853.Bcav_3313	0.000426	50.1	COG1609@1|root,COG1609@2|Bacteria,2GMUU@201174|Actinobacteria	201174|Actinobacteria	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529,ko:K05499	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
k59_243659_1	272943.RSP_1466	1.15e-07	58.2	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,2TQVX@28211|Alphaproteobacteria,1FBDK@1060|Rhodobacter	28211|Alphaproteobacteria	L	helix-hairpin-helix motif	mutY	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
k59_1415663_1	397278.JOJN01000002_gene367	1.02e-76	242.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4DN6Q@85009|Propionibacteriales	201174|Actinobacteria	BQ	Histone deacetylase domain	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
k59_68381_1	1049564.TevJSym_ak00590	1.11e-164	478.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1J5IS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_1829420_2	768671.ThimaDRAFT_0112	2.05e-72	234.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WWSA@135613|Chromatiales	135613|Chromatiales	U	sulphate transporter	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1415666_1	1454004.AW11_02355	1.68e-107	322.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,2VHKV@28216|Betaproteobacteria,1KQSG@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_418148_1	1353531.AZNX01000010_gene1069	8.06e-86	275.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_891393_1	1005048.CFU_0720	1.48e-23	94.0	COG0783@1|root,COG0783@2|Bacteria,1RAC5@1224|Proteobacteria,2VHJI@28216|Betaproteobacteria,474AV@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Belongs to the Dps family	dps	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
k59_891393_2	713586.KB900536_gene1625	1.44e-21	86.3	COG3205@1|root,COG3205@2|Bacteria,1N85D@1224|Proteobacteria,1SCCN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	VP2647	-	-	-	-	-	-	-	-	-	-	-	DUF2061
k59_363173_1	446469.Sked_11390	7.41e-172	517.0	COG1530@1|root,COG5373@1|root,COG1530@2|Bacteria,COG5373@2|Bacteria,2GMM5@201174|Actinobacteria	201174|Actinobacteria	J	ribonuclease Rne Rng family	rne	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	IF2_N,RNase_E_G,S1
k59_594396_2	44454.NF84_23265	2.96e-92	275.0	COG5340@1|root,COG5340@2|Bacteria,2IDWV@201174|Actinobacteria	201174|Actinobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_1,AbiEi_4
k59_1416727_1	1089548.KI783301_gene1245	5.89e-24	100.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4H9NW@91061|Bacilli,3WF7E@539002|Bacillales incertae sedis	91061|Bacilli	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_1065705_1	335543.Sfum_1198	1.05e-91	283.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,2MQYI@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Carbohydrate phosphorylase	-	-	2.4.1.1,2.4.1.11	ko:K00688,ko:K16153	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R00292,R02111	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT3,GT35	-	DUF3417,Phosphorylase
k59_829180_1	1304875.JAFZ01000002_gene271	7.05e-05	44.3	COG2265@1|root,COG2265@2|Bacteria,3TAEF@508458|Synergistetes	508458|Synergistetes	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_U5-meth_tr
k59_829180_2	395493.BegalDRAFT_3276	2.16e-61	196.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,460S6@72273|Thiotrichales	72273|Thiotrichales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
k59_1709602_1	446469.Sked_14830	8.6e-07	55.8	COG0383@1|root,COG0383@2|Bacteria,2GM02@201174|Actinobacteria	201174|Actinobacteria	G	PFAM Glycoside hydrolase, family 38	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
k59_1357522_1	1049564.TevJSym_aj00120	2.87e-77	248.0	COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,1S6AN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KT	phosphohydrolase	rela3	-	-	-	-	-	-	-	-	-	-	-	HD_4
k59_1004397_1	1137799.GZ78_25185	1.37e-20	89.7	COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,1S3Y1@1236|Gammaproteobacteria,1XJ4Z@135619|Oceanospirillales	135619|Oceanospirillales	S	Bacterial transglutaminase-like cysteine proteinase BTLCP	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C93
k59_1591891_1	593907.Celgi_2023	9.92e-85	260.0	COG0039@1|root,COG0039@2|Bacteria,2GN5S@201174|Actinobacteria,4F1NU@85016|Cellulomonadaceae	201174|Actinobacteria	C	Belongs to the LDH MDH superfamily. LDH family	ldh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
k59_829182_1	367299.JOEE01000001_gene2162	1.54e-224	655.0	COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria,4FFYE@85021|Intrasporangiaceae	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_712002_1	1245471.PCA10_25010	2.15e-10	62.8	COG4796@1|root,COG4796@2|Bacteria,1RCNA@1224|Proteobacteria,1SE5I@1236|Gammaproteobacteria,1YFNX@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	U	Bacterial type II/III secretion system short domain	-	-	-	-	-	-	-	-	-	-	-	-	Secretin,Secretin_N
k59_950406_1	748247.AZKH_1670	1.69e-68	232.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2VKF8@28216|Betaproteobacteria	28216|Betaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_950406_2	349124.Hhal_1916	6.25e-08	55.1	COG0845@1|root,COG0845@2|Bacteria,1PDUT@1224|Proteobacteria,1RQKD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_3,HlyD_D23,OEP
k59_1709604_1	1049564.TevJSym_aj00400	3.02e-42	141.0	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,1J60Z@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the MraZ family	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
k59_1709604_2	1323663.AROI01000006_gene3000	8.32e-93	282.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_363202_1	1267005.KB911263_gene1376	1.41e-117	345.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2TR0T@28211|Alphaproteobacteria,3N6FK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ATPase AAA	moxR	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_653313_1	1123065.ATWL01000013_gene1130	1.67e-22	94.4	COG3012@1|root,COG3012@2|Bacteria,2GJ7F@201174|Actinobacteria	201174|Actinobacteria	S	SEC-C motif	-	-	-	-	-	-	-	-	-	-	-	-	SEC-C
k59_477049_1	1095767.CAHD01000232_gene2922	7.63e-145	427.0	COG3590@1|root,COG3590@2|Bacteria,2GNJY@201174|Actinobacteria,4F0H2@85016|Cellulomonadaceae	201174|Actinobacteria	O	Peptidase family M13	pepO	-	3.4.24.11,3.4.24.71	ko:K01389,ko:K01415,ko:K07386	ko04614,ko04640,ko04974,ko05010,map04614,map04640,map04974,map05010	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
k59_1830767_1	1120999.JONM01000006_gene2458	1.27e-29	116.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,2VIFC@28216|Betaproteobacteria,2KPIX@206351|Neisseriales	206351|Neisseriales	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
k59_1302601_1	1442599.JAAN01000024_gene1877	3.42e-96	297.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RMKV@1236|Gammaproteobacteria,1X49X@135614|Xanthomonadales	135614|Xanthomonadales	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_1709619_1	396588.Tgr7_3255	2.35e-77	251.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1WWSJ@135613|Chromatiales	135613|Chromatiales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_1709619_2	1122197.ATWI01000012_gene504	3.51e-35	130.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,4640E@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	glycyl-tRNA synthetase alpha subunit	glyQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF1260.b3560,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360	tRNA-synt_2e
k59_1591912_1	754476.Q7A_64	1.45e-129	396.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,45ZWK@72273|Thiotrichales	72273|Thiotrichales	M	TIGRFAM penicillin-binding protein, 1A	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_773041_1	247633.GP2143_16216	1.11e-31	119.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1J4QV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	stress-induced protein	yicC	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
k59_773041_2	523791.Kkor_2429	1.89e-52	172.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1XJ5P@135619|Oceanospirillales	135619|Oceanospirillales	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
k59_253815_2	1166018.FAES_4804	7.28e-10	68.6	COG1033@1|root,COG1033@2|Bacteria,4NE0M@976|Bacteroidetes,47JQA@768503|Cytophagia	976|Bacteroidetes	S	COGs COG1033 exporter of the RND superfamily protein	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_253816_1	446466.Cfla_0232	8.14e-31	117.0	COG4430@1|root,COG4430@2|Bacteria,2II0D@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
k59_1596103_1	768671.ThimaDRAFT_1053	1.81e-97	288.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,1RNWH@1236|Gammaproteobacteria,1WW9E@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02483,ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1836899_1	1286106.MPL1_09245	1.74e-126	385.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,45ZWF@72273|Thiotrichales	72273|Thiotrichales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_1713714_1	349124.Hhal_0025	2.3e-63	209.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,1RNUS@1236|Gammaproteobacteria,1WWB4@135613|Chromatiales	135613|Chromatiales	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_1537713_1	335543.Sfum_1585	1.33e-19	88.6	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,42MRJ@68525|delta/epsilon subdivisions,2WITA@28221|Deltaproteobacteria,2MQ55@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
k59_1308693_1	1120956.JHZK01000013_gene2582	6.26e-16	83.2	2CKRE@1|root,32SCW@2|Bacteria,1MWRU@1224|Proteobacteria,2TSRM@28211|Alphaproteobacteria,1JQJV@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2865)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2865
k59_1656183_2	1469245.JFBG01000038_gene1806	1.66e-59	193.0	COG1117@1|root,COG1117@2|Bacteria	2|Bacteria	P	ATPase-coupled phosphate ion transmembrane transporter activity	pstB	-	3.6.3.27,3.6.3.55	ko:K02036,ko:K06857	ko02010,map02010	M00186,M00222	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4,3.A.1.7	-	-	ABC_tran
k59_1596110_1	583355.Caka_0248	5.26e-06	56.6	COG0659@1|root,COG0659@2|Bacteria,46THR@74201|Verrucomicrobia,3K7K8@414999|Opitutae	414999|Opitutae	P	Sulfate transporter antisigma-factor antagonist STAS	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_188334_1	1380370.JIBA01000003_gene2780	1.21e-21	98.2	COG5278@1|root,COG5278@2|Bacteria,2GJ1Q@201174|Actinobacteria,4FG3T@85021|Intrasporangiaceae	201174|Actinobacteria	T	phosphoserine phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_188334_2	1380354.JIAN01000006_gene586	3.65e-05	45.4	COG0464@1|root,COG0464@2|Bacteria,2GJWA@201174|Actinobacteria	201174|Actinobacteria	O	AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_657961_1	1469245.JFBG01000056_gene2481	2.66e-34	122.0	COG2010@1|root,COG2010@2|Bacteria,1N91W@1224|Proteobacteria,1SD5N@1236|Gammaproteobacteria,1WYSI@135613|Chromatiales	135613|Chromatiales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K17223	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_1421396_1	66377.JOBH01000004_gene3709	2.01e-45	152.0	COG1959@1|root,COG1959@2|Bacteria,2INF3@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
k59_1125508_1	105559.Nwat_1981	4.03e-74	234.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,1WX2W@135613|Chromatiales	135613|Chromatiales	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
k59_957433_1	110319.CF8_4142	2.78e-94	284.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	ylbG	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_29,rve,rve_3
k59_1772788_1	232721.Ajs_0146	6.69e-98	301.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2VHQS@28216|Betaproteobacteria,4AGB5@80864|Comamonadaceae	28216|Betaproteobacteria	K	sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K06714	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,PAS_4,Sigma54_activat
k59_1422006_1	76869.PputGB1_0419	1.37e-109	336.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1YWGH@136845|Pseudomonas putida group	1236|Gammaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_423217_1	243233.MCA1224	1.08e-45	152.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,1S93F@1236|Gammaproteobacteria,1XFE7@135618|Methylococcales	135618|Methylococcales	S	Tol-Pal system-associated acyl-CoA thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
k59_423217_2	1049564.TevJSym_be00110	7.4e-71	223.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1J4F2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_1362437_1	634956.Geoth_2310	2.71e-14	74.3	COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,4HBB8@91061|Bacilli,1WG35@129337|Geobacillus	91061|Bacilli	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K11961	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
k59_1362437_2	1401065.HMPREF2130_07905	2.88e-15	78.6	COG0411@1|root,COG0559@1|root,COG4177@1|root,COG0411@2|Bacteria,COG0559@2|Bacteria,COG4177@2|Bacteria,1MY1E@1224|Proteobacteria,2VMZ5@28216|Betaproteobacteria,3T2Q5@506|Alcaligenaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
k59_599092_1	1191460.F959_02370	1.11e-23	99.4	COG3676@1|root,COG3676@2|Bacteria,1QTF7@1224|Proteobacteria,1RS58@1236|Gammaproteobacteria,3NP2B@468|Moraxellaceae	1236|Gammaproteobacteria	L	ISXO2-like transposase domain	-	-	-	ko:K07488	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1595
k59_1772793_1	981384.AEYW01000028_gene4248	7.99e-40	147.0	2F138@1|root,33U4R@2|Bacteria,1NUMP@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1073510_1	1255043.TVNIR_0484	1.18e-81	258.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1WWXH@135613|Chromatiales	135613|Chromatiales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1187044_1	1158150.KB906243_gene1764	3.45e-36	128.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,1WX1Y@135613|Chromatiales	135613|Chromatiales	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
k59_1187044_2	522373.Smlt3715	2.43e-12	67.8	COG1075@1|root,COG1075@2|Bacteria,1N2W0@1224|Proteobacteria,1SAMR@1236|Gammaproteobacteria,1X6RA@135614|Xanthomonadales	135614|Xanthomonadales	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Abhydrolase_8
k59_423220_1	1123401.JHYQ01000003_gene2041	5.97e-89	283.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,4601N@72273|Thiotrichales	72273|Thiotrichales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_130295_1	1288494.EBAPG3_20890	1.23e-68	219.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria,371PD@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_1837832_2	2340.JV46_24050	5.61e-59	195.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Flavocytochrome c sulphide dehydrogenase, flavin-binding	-	-	-	-	-	-	-	-	-	-	-	-	FCSD-flav_bind,Pyr_redox_2
k59_540829_1	570967.JMLV01000004_gene650	5.7e-34	125.0	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,2TSFD@28211|Alphaproteobacteria,2JQTE@204441|Rhodospirillales	204441|Rhodospirillales	E	Putrescine transport system permease	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_540829_2	1469245.JFBG01000030_gene1534	6.97e-143	413.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,1RM7W@1236|Gammaproteobacteria,1WWKM@135613|Chromatiales	135613|Chromatiales	E	Required for the activity of the bacterial periplasmic transport system of putrescine	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
k59_1714339_1	397945.Aave_3695	7.29e-49	170.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,4AAVH@80864|Comamonadaceae	28216|Betaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
k59_1714339_2	1169143.KB911047_gene5487	1.92e-28	110.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2VIR6@28216|Betaproteobacteria,1K1CF@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Cytochrome C1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
k59_1008526_2	1122137.AQXF01000003_gene2335	5.07e-53	180.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2TTMG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
k59_76653_2	545276.KB898727_gene377	7.94e-80	242.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1WWXG@135613|Chromatiales	135613|Chromatiales	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
k59_1248663_1	279714.FuraDRAFT_3207	0.000768	41.6	COG2116@1|root,COG2116@2|Bacteria,1MU0W@1224|Proteobacteria,2VKMF@28216|Betaproteobacteria,2KRVB@206351|Neisseriales	206351|Neisseriales	P	Formate/nitrite transporter	fnt	-	-	ko:K02598,ko:K21993	-	-	-	-	ko00000,ko02000	1.A.16.2,1.A.16.3	-	-	Form_Nir_trans
k59_1248663_2	926567.TheveDRAFT_1719	1.1e-09	60.8	COG2116@1|root,COG2116@2|Bacteria,3TA4X@508458|Synergistetes	508458|Synergistetes	P	PFAM formate nitrite transporter	fnt	-	-	ko:K21993	-	-	-	-	ko00000,ko02000	1.A.16.2	-	-	Form_Nir_trans
k59_1126074_1	768671.ThimaDRAFT_3170	1.65e-67	209.0	2EP9T@1|root,33GWJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_957468_1	243090.RB9427	2.75e-40	150.0	COG2304@1|root,COG2304@2|Bacteria,2J3A9@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
k59_21139_2	1304885.AUEY01000022_gene3380	2.48e-16	79.3	COG2911@1|root,COG2911@2|Bacteria,1PQTA@1224|Proteobacteria,42PYT@68525|delta/epsilon subdivisions,2WIZ6@28221|Deltaproteobacteria,2MJ1Q@213118|Desulfobacterales	28221|Deltaproteobacteria	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
k59_1596830_1	1713.JOFV01000002_gene591	8.88e-66	224.0	COG5617@1|root,COG5617@2|Bacteria,2HKW0@201174|Actinobacteria	201174|Actinobacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_423245_1	1121937.AUHJ01000005_gene2242	2.77e-72	241.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,464UX@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG0474 Cation transport ATPase	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_599114_1	391600.ABRU01000021_gene908	3.04e-52	177.0	COG3555@1|root,COG3555@2|Bacteria,1MW3M@1224|Proteobacteria,2U5YV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Aspartyl/Asparaginyl beta-hydroxylase	-	-	-	ko:K12979	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	Asp_Arg_Hydrox,TPR_8
k59_1596837_1	1260251.SPISAL_03055	7.35e-46	166.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1WVW8@135613|Chromatiales	135613|Chromatiales	EF	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_21147_1	452637.Oter_0894	3.6e-162	496.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,46U9T@74201|Verrucomicrobia,3K7GP@414999|Opitutae	414999|Opitutae	E	glutamate synthase	-	-	1.4.7.1	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	-	R00021,R10086	RC00006,RC00010	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1362475_1	1229172.JQFA01000002_gene5049	2.09e-92	292.0	COG1523@1|root,COG1523@2|Bacteria,1G0PW@1117|Cyanobacteria,1H8QW@1150|Oscillatoriales	1117|Cyanobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_1656848_1	305900.GV64_17700	1.54e-51	177.0	COG0111@1|root,COG0111@2|Bacteria,1N5TD@1224|Proteobacteria,1RMFW@1236|Gammaproteobacteria,1XHAR@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate	pdxB	-	1.1.1.290	ko:K03473	ko00750,ko01100,map00750,map01100	M00124	R04210	RC00084	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C,DUF3410
k59_540837_1	519989.ECTPHS_10276	5.5e-164	474.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1WWEZ@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_540837_2	768671.ThimaDRAFT_3900	4.45e-32	114.0	COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,1SCPF@1236|Gammaproteobacteria,1WZC1@135613|Chromatiales	135613|Chromatiales	C	acylphosphatase	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
k59_540837_3	292415.Tbd_2118	1.05e-41	144.0	COG0526@1|root,COG0526@2|Bacteria,1RKKW@1224|Proteobacteria,2WEVJ@28216|Betaproteobacteria,1KT3T@119069|Hydrogenophilales	119069|Hydrogenophilales	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_540837_4	765910.MARPU_05510	8.39e-213	600.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,1RN8U@1236|Gammaproteobacteria,1WWUB@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the reversible hydration of fumarate to (S)- malate	-	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
k59_1187074_1	504728.K649_12130	1.2e-22	89.4	2BMUI@1|root,32GE2@2|Bacteria,1WKN5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
k59_1187074_2	1121413.JMKT01000011_gene2313	1.39e-24	98.2	COG0758@1|root,COG0758@2|Bacteria,1MZGB@1224|Proteobacteria,42SVE@68525|delta/epsilon subdivisions,2WN0M@28221|Deltaproteobacteria,2MD10@213115|Desulfovibrionales	28221|Deltaproteobacteria	LU	Putative molybdenum carrier	-	-	-	-	-	-	-	-	-	-	-	-	MoCo_carrier
k59_1596843_1	926569.ANT_23120	3.42e-90	273.0	COG3764@1|root,COG3764@2|Bacteria,2G98S@200795|Chloroflexi	200795|Chloroflexi	M	PFAM peptidase C60, sortase A and B	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
k59_188993_2	1279038.KB907337_gene178	6.27e-10	61.2	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2TRKT@28211|Alphaproteobacteria,2JQTN@204441|Rhodospirillales	204441|Rhodospirillales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_957499_1	686340.Metal_1334	1.63e-05	49.3	COG3000@1|root,COG3000@2|Bacteria,1NR7X@1224|Proteobacteria,1RQDX@1236|Gammaproteobacteria,1XECS@135618|Methylococcales	135618|Methylococcales	I	Fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934,FA_hydroxylase
k59_957499_2	765912.Thimo_0539	6.05e-203	596.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWSZ@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1656859_1	765910.MARPU_12575	2.13e-62	204.0	COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1MV72@1224|Proteobacteria,1RPH5@1236|Gammaproteobacteria,1WXHI@135613|Chromatiales	135613|Chromatiales	C	Oxidoreductase FAD-binding domain	-	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
k59_76704_1	156889.Mmc1_1519	6.41e-72	241.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2TRI9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	exporters of the RND superfamily	MA20_16090	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_1656861_1	351746.Pput_1978	1.44e-50	167.0	COG0582@1|root,COG0582@2|Bacteria,1P1R9@1224|Proteobacteria,1RRV0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
k59_1248709_1	1463857.JOFZ01000015_gene905	6.06e-70	221.0	2BW2W@1|root,33QDJ@2|Bacteria,2I8ZU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1248709_2	1449355.JQNR01000005_gene5684	7.47e-08	53.1	2FACT@1|root,342M5@2|Bacteria,2HHWB@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1362491_1	159087.Daro_2608	4.71e-45	154.0	COG0106@1|root,COG0106@2|Bacteria,1RF9S@1224|Proteobacteria,2VS3S@28216|Betaproteobacteria,2KWDH@206389|Rhodocyclales	206389|Rhodocyclales	E	Histidine biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	His_biosynth
k59_1362491_2	748247.AZKH_p0057	4.43e-26	103.0	COG0607@1|root,COG0607@2|Bacteria,1RHNV@1224|Proteobacteria,2VSK8@28216|Betaproteobacteria,2KWKY@206389|Rhodocyclales	206389|Rhodocyclales	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1772841_1	882.DVU_0069	1.08e-22	103.0	COG0419@1|root,COG4717@1|root,COG0419@2|Bacteria,COG4717@2|Bacteria,1MVAW@1224|Proteobacteria,42MYC@68525|delta/epsilon subdivisions,2WJXA@28221|Deltaproteobacteria,2M8XJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_27
k59_1126110_1	713586.KB900536_gene510	7.18e-54	179.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1WW48@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_1837901_1	1121895.Q765_02080	2.91e-68	223.0	COG1073@1|root,COG1073@2|Bacteria,4NGG4@976|Bacteroidetes,1IMUE@117743|Flavobacteriia,2NUXE@237|Flavobacterium	976|Bacteroidetes	S	Dienelactone hydrolase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	DLH,Hydrolase_4
k59_482058_1	1282876.BAOK01000001_gene3440	3.61e-55	187.0	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2TQUH@28211|Alphaproteobacteria,4BPH7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	NAD FAD-binding protein	-	-	-	ko:K06954	-	-	-	-	ko00000	-	-	-	Amino_oxidase,NAD_binding_8
k59_658689_1	344747.PM8797T_10474	3.55e-73	231.0	COG0523@1|root,COG0523@2|Bacteria,2IXBH@203682|Planctomycetes	203682|Planctomycetes	S	PFAM cobalamin synthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
k59_370251_1	84531.JMTZ01000087_gene1416	3.47e-80	260.0	COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,1T2IM@1236|Gammaproteobacteria,1XD6E@135614|Xanthomonadales	135614|Xanthomonadales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_305846_1	156889.Mmc1_0226	1.45e-61	213.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,2TRF9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Na phosphate symporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans
k59_1073635_1	743719.PaelaDRAFT_4484	4.32e-72	233.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,4HAFB@91061|Bacilli,26R27@186822|Paenibacillaceae	91061|Bacilli	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_482069_1	1123258.AQXZ01000016_gene2353	3.91e-77	242.0	COG0208@1|root,COG0208@2|Bacteria,2GJKZ@201174|Actinobacteria,4G72S@85025|Nocardiaceae	201174|Actinobacteria	F	P-aminobenzoate N-oxygenase AurF	-	-	-	-	-	-	-	-	-	-	-	-	AurF
k59_1538504_1	936136.ARRT01000006_gene2477	1.61e-72	234.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,4B86M@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	electron transfer flavoprotein-ubiquinone oxidoreductase	etf	GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070013,GO:0098573,GO:0098798,GO:1902494,GO:1990204	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8,Thi4
k59_834445_1	754476.Q7A_1142	1.07e-28	112.0	COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,1S95P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	yfgM	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0044425,GO:0044459,GO:0044464,GO:0071575,GO:0071944,GO:0098552	-	-	-	-	-	-	-	-	-	-	TPR_21
k59_834445_2	1452718.JBOY01000023_gene278	7.24e-79	248.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	histidyl-tRNA synthetase	hisS	GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358	HGTP_anticodon,tRNA-synt_His
k59_1084742_1	1385935.N836_34445	1.91e-08	60.5	COG1403@1|root,COG3344@1|root,COG1403@2|Bacteria,COG3344@2|Bacteria,1G065@1117|Cyanobacteria,1HADY@1150|Oscillatoriales	1117|Cyanobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,HNH,RVT_1,RVT_N
k59_138246_1	768671.ThimaDRAFT_0227	7.45e-26	110.0	COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,1RPD2@1236|Gammaproteobacteria,1WXID@135613|Chromatiales	135613|Chromatiales	S	doubled CXXCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Paired_CXXCH_1,TPR_19,TPR_8
k59_1320874_1	395493.BegalDRAFT_2410	1.8e-103	321.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,4605A@72273|Thiotrichales	72273|Thiotrichales	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_607176_1	987059.RBXJA2T_08610	5.06e-120	355.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VHST@28216|Betaproteobacteria,1KIYT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.113	ko:K12256	ko00330,ko01100,map00330,map01100	-	R08714	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_842343_1	880072.Desac_0706	3.71e-67	221.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MIZ@68525|delta/epsilon subdivisions,2WIUX@28221|Deltaproteobacteria,2MQZB@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Integral membrane sensor signal transduction histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	CHASE5,HAMP,HATPase_c,HisKA,dCache_1,dCache_2
k59_1320881_1	765911.Thivi_1285	2.26e-109	328.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,1RQGG@1236|Gammaproteobacteria,1WW8R@135613|Chromatiales	135613|Chromatiales	C	Seven times multi-haem cytochrome CxxCH	-	-	1.7.2.6	ko:K10535	ko00910,ko01120,map00910,map01120	M00528,M00804	R10164	RC00383	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrome_C554,Multi-haem_cyto
k59_489953_1	234267.Acid_3490	9.86e-20	94.0	2DBAV@1|root,2Z84I@2|Bacteria,3Y9AH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1849049_1	272630.MexAM1_META1p2949	1.69e-12	72.4	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,1JS3R@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM Peptidoglycan-binding domain 1 protein	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_266487_1	555779.Dthio_PD3239	4.02e-64	216.0	COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit	-	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
k59_1258958_1	435908.IDSA_03405	2.32e-06	49.7	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria,2QG26@267893|Idiomarinaceae	1236|Gammaproteobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050518,GO:0070567,GO:0071704,GO:1901576	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2747,iBWG_1329.BWG_2483,iEC55989_1330.EC55989_3019,iECDH10B_1368.ECDH10B_2915,iECDH1ME8569_1439.ECDH1ME8569_2657,iECIAI1_1343.ECIAI1_2848,iECO103_1326.ECO103_3289,iECO111_1330.ECO111_3471,iECO26_1355.ECO26_3816,iECSE_1348.ECSE_2999,iECW_1372.ECW_m2953,iEKO11_1354.EKO11_1022,iEcDH1_1363.EcDH1_0941,iEcE24377_1341.EcE24377A_3048,iEcHS_1320.EcHS_A2885,iEcolC_1368.EcolC_0965,iJO1366.b2747,iJR904.b2747,iPC815.YPO3361,iSBO_1134.SBO_2773,iSDY_1059.SDY_2946,iSSON_1240.SSON_2895,iSbBS512_1146.SbBS512_E3127,iUMNK88_1353.UMNK88_3422,iWFL_1372.ECW_m2953,iY75_1357.Y75_RS14300	IspD
k59_1258958_2	105559.Nwat_2254	7.16e-22	89.4	COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,1SD8H@1236|Gammaproteobacteria,1WZ9J@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsB	-	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
k59_909657_1	713586.KB900536_gene2324	1.46e-62	199.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1WZW4@135613|Chromatiales	135613|Chromatiales	L	Endonuclease/Exonuclease/phosphatase family	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_909657_2	1205680.CAKO01000040_gene851	1.01e-120	363.0	COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,2TTD2@28211|Alphaproteobacteria,2JYWZ@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Acetyl-coenzyme A transporter 1	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
k59_431126_1	656024.FsymDg_2441	3.82e-71	235.0	COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria,4ERGD@85013|Frankiales	201174|Actinobacteria	G	Belongs to the transketolase family	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_1195155_1	1163617.SCD_n01349	2.72e-54	187.0	COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,2VIE1@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl transferase, family 4	wecA	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
k59_266507_1	1158146.KB907121_gene1069	7.27e-05	42.7	COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria,1SCH1@1236|Gammaproteobacteria,1WYUC@135613|Chromatiales	135613|Chromatiales	S	Membrane fusogenic activity	-	-	-	ko:K09806	-	-	-	-	ko00000	-	-	-	BMFP
k59_266507_2	1415755.JQLV01000001_gene3725	1.68e-60	188.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1XKBF@135619|Oceanospirillales	135619|Oceanospirillales	K	Belongs to the P(II) protein family	-	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
k59_266507_3	566466.NOR53_2913	5.01e-33	124.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1J4I3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Ammonium Transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_1546345_1	1125863.JAFN01000001_gene1761	1.35e-61	212.0	COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	ATPase BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
k59_909683_1	1348657.M622_14455	3.52e-61	204.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2VH5Q@28216|Betaproteobacteria,2KYJ0@206389|Rhodocyclales	206389|Rhodocyclales	EG	dihydroxy-acid dehydratase activity	-	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_1320919_1	316067.Geob_0201	1.99e-05	48.9	COG0427@1|root,COG0454@1|root,COG0427@2|Bacteria,COG0456@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_2142	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
k59_1722462_1	1280941.HY2_11285	8.52e-47	166.0	COG2234@1|root,COG2234@2|Bacteria,1NE83@1224|Proteobacteria,2TSF8@28211|Alphaproteobacteria,43W8R@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Peptidase M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_1258989_1	323261.Noc_2707	8.77e-100	308.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WZYZ@135613|Chromatiales	135613|Chromatiales	C	aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_666524_1	765912.Thimo_1229	4.67e-43	152.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1S2IK@1236|Gammaproteobacteria,1WZ20@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_666524_2	765912.Thimo_1228	5.6e-32	124.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWB8@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_266525_1	1144275.COCOR_05185	9.2e-40	141.0	COG0596@1|root,COG0596@2|Bacteria,1R4N4@1224|Proteobacteria,434SV@68525|delta/epsilon subdivisions,2WZ3Y@28221|Deltaproteobacteria,2Z19T@29|Myxococcales	28221|Deltaproteobacteria	S	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_266525_2	68199.JNZO01000050_gene1578	1.47e-06	52.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1195173_1	439235.Dalk_1317	6.82e-217	610.0	COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,42Q03@68525|delta/epsilon subdivisions,2WMFQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_32824_1	443143.GM18_0341	1.22e-73	242.0	COG2133@1|root,COG2133@2|Bacteria,1NRFC@1224|Proteobacteria,42YAV@68525|delta/epsilon subdivisions,2WTUF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1780949_1	593907.Celgi_2754	3.99e-120	354.0	COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria,4F124@85016|Cellulomonadaceae	201174|Actinobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_1084795_1	1280950.HJO_00925	3.08e-76	238.0	COG2519@1|root,COG2519@2|Bacteria,1QWVH@1224|Proteobacteria,2TYVF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_1084795_2	1280950.HJO_07927	1.12e-10	60.1	COG1733@1|root,COG1733@2|Bacteria,1NEKW@1224|Proteobacteria,2U0MC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HxlR,SCP2
k59_32836_1	1317124.DW2_18014	6.02e-16	82.4	COG2244@1|root,COG2244@2|Bacteria,1N3BW@1224|Proteobacteria,2UE08@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Membrane protein involved in the export of O-antigen and teichoic	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3
k59_1430218_1	1267534.KB906757_gene952	6.27e-41	137.0	2C19F@1|root,32ZRH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_842396_1	375286.mma_2411	1.95e-46	171.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2VHKJ@28216|Betaproteobacteria,474CI@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_266565_2	1158146.KB907132_gene42	1.14e-41	150.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1WXE2@135613|Chromatiales	135613|Chromatiales	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_725004_1	1307759.JOMJ01000004_gene2462	7.74e-49	171.0	COG2010@1|root,COG2010@2|Bacteria,1RIY5@1224|Proteobacteria	1224|Proteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_87904_1	754477.Q7C_1937	8.94e-133	389.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,46093@72273|Thiotrichales	72273|Thiotrichales	LU	TIGRFAM DNA protecting protein DprA	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_87904_2	395493.BegalDRAFT_3319	1.03e-46	156.0	COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,4612G@72273|Thiotrichales	72273|Thiotrichales	S	Belongs to the Smg family	smg	-	-	ko:K03747	-	-	-	-	ko00000	-	-	-	DUF494
k59_1849155_1	933262.AXAM01000036_gene2164	1.29e-69	231.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2MI3D@213118|Desulfobacterales	28221|Deltaproteobacteria	L	UvrD REP helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1849155_2	933262.AXAM01000008_gene1977	0.000922	40.8	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,42MYT@68525|delta/epsilon subdivisions,2WM6R@28221|Deltaproteobacteria,2MI10@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_607249_1	396595.TK90_2178	5.5e-47	156.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1WXDE@135613|Chromatiales	135613|Chromatiales	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_1259043_1	1306174.JODP01000009_gene6294	2.93e-56	181.0	COG2337@1|root,COG2337@2|Bacteria,2GM10@201174|Actinobacteria	201174|Actinobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PemK_toxin
k59_1259047_2	925775.XVE_4460	1.85e-12	71.6	COG3595@1|root,COG3595@2|Bacteria,1P19T@1224|Proteobacteria,1RRSR@1236|Gammaproteobacteria,1X62K@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
k59_968758_1	314278.NB231_08320	5.38e-33	120.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1WVZP@135613|Chromatiales	135613|Chromatiales	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_842425_1	626887.J057_17900	9.19e-41	145.0	COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,4645R@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	COG2269 Truncated, possibly inactive, lysyl-tRNA synthetase (class II)	epmA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016746,GO:0016755,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052868,GO:0071704,GO:0071915,GO:0072580,GO:0072581,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
k59_381473_1	1238190.AMQY01000025_gene72	1.39e-44	160.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1XHBV@135619|Oceanospirillales	135619|Oceanospirillales	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
k59_780421_1	1123073.KB899242_gene997	4.09e-75	240.0	COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,1X361@135614|Xanthomonadales	135614|Xanthomonadales	G	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane	lapB	-	-	ko:K19804	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_7
k59_1084842_1	472759.Nhal_1097	3.97e-102	318.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1WWAD@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_911339_1	1165096.ARWF01000001_gene1887	2.08e-37	133.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2VIHD@28216|Betaproteobacteria,2KM9Y@206350|Nitrosomonadales	206350|Nitrosomonadales	L	TIGRFAM tyrosine recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_911339_2	555778.Hneap_2121	5.36e-44	153.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1WWG5@135613|Chromatiales	135613|Chromatiales	V	pfam abc	-	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
k59_268303_1	1396141.BATP01000001_gene5330	2.63e-100	310.0	28HMZ@1|root,2Z7WD@2|Bacteria,46TFX@74201|Verrucomicrobia,2IVCD@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_843410_1	469371.Tbis_1552	3.32e-74	239.0	COG0804@1|root,COG0804@2|Bacteria,2GM7X@201174|Actinobacteria,4E041@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
k59_1260301_1	632245.CLP_2666	2.2e-44	156.0	COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,249H9@186801|Clostridia,36E42@31979|Clostridiaceae	186801|Clostridia	NU	twitching motility protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_1371347_1	768671.ThimaDRAFT_3447	2.83e-18	84.7	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1WXDC@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM Asparagine synthase family amidotransferase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_1371347_2	1121015.N789_12570	1.38e-18	85.1	COG1108@1|root,COG1108@2|Bacteria,1QJJ7@1224|Proteobacteria,1S3BV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	PFAM ABC-3 protein	-	-	-	ko:K02075	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
k59_383085_2	1121033.AUCF01000029_gene301	2.46e-25	97.4	2EG5Z@1|root,339XV@2|Bacteria,1NN9Y@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1666112_1	1042876.PPS_3815	8.21e-31	121.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1YW0A@136845|Pseudomonas putida group	1236|Gammaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_1666112_2	1249627.D779_0035	2e-27	110.0	COG0642@1|root,COG2204@1|root,COG2204@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1WW92@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_34723_1	557598.LHK_03005	8.51e-37	131.0	COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,2VRMS@28216|Betaproteobacteria,2KR00@206351|Neisseriales	206351|Neisseriales	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
k59_139226_1	1157490.EL26_22810	8.68e-83	256.0	COG2043@1|root,COG2043@2|Bacteria,1TT5P@1239|Firmicutes,4HFED@91061|Bacilli,2796U@186823|Alicyclobacillaceae	91061|Bacilli	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
k59_139226_2	1453501.JELR01000001_gene2956	6.47e-32	124.0	COG1757@1|root,COG1757@2|Bacteria,1MVDF@1224|Proteobacteria,1RS40@1236|Gammaproteobacteria,464WZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Na H antiporter	nhaC	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
k59_970394_1	686340.Metal_2871	4.57e-74	236.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,1XES2@135618|Methylococcales	135618|Methylococcales	S	PFAM alpha beta hydrolase	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1
k59_1547284_1	1249627.D779_3516	5.76e-147	429.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales	135613|Chromatiales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_315103_1	582899.Hden_3248	9.2e-18	75.9	2EIRC@1|root,33CGS@2|Bacteria,1NGFG@1224|Proteobacteria,2UJFR@28211|Alphaproteobacteria,3N7GA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	-	-	-	ko:K02196	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.107	-	-	CcmD
k59_315103_2	639283.Snov_2781	3.67e-36	129.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2TSEW@28211|Alphaproteobacteria,3EZAN@335928|Xanthobacteraceae	28211|Alphaproteobacteria	CO	Redoxin	ccmG	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
k59_1850837_1	367299.JOEE01000012_gene3229	9.38e-89	275.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,4FFTK@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the peptidase M24B family	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_1781831_1	933262.AXAM01000010_gene1372	1.61e-31	117.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,42MMS@68525|delta/epsilon subdivisions,2WMUI@28221|Deltaproteobacteria,2MIBY@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM hydrolase, TatD family	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_14,Radical_SAM,TatD_DNase
k59_34743_1	84531.JMTZ01000020_gene3702	2.1e-98	296.0	COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,1RNBX@1236|Gammaproteobacteria,1X45S@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyl-CoA dehydrogenase	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_667486_1	1713.JOFV01000004_gene3442	2.51e-43	154.0	COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4F1WF@85016|Cellulomonadaceae	201174|Actinobacteria	M	Peptidase family M50	rip1	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
k59_667486_2	1095767.CAHD01000226_gene1002	1.57e-99	297.0	COG0743@1|root,COG0743@2|Bacteria,2GIRV@201174|Actinobacteria,4F0QX@85016|Cellulomonadaceae	201174|Actinobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2870c	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_1547290_1	1120953.AUBH01000007_gene1867	1e-40	139.0	COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,1S3PW@1236|Gammaproteobacteria,466RV@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	lipocalin	blc	GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033554,GO:0044462,GO:0044464,GO:0050896,GO:0051716,GO:0071944	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
k59_1494773_1	1123355.JHYO01000008_gene2681	1.65e-41	155.0	COG2172@1|root,COG2203@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,1PFBR@1224|Proteobacteria,2U1RE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Sigma factor PP2C-like phosphatases	rsbU	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c_2,SpoIIE
k59_1494773_2	1244869.H261_16957	5.8e-26	100.0	COG1366@1|root,COG1366@2|Bacteria,1N6U1@1224|Proteobacteria,2UFPK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
k59_1494773_3	338963.Pcar_0447	2.93e-119	349.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MR1@68525|delta/epsilon subdivisions,2WKC9@28221|Deltaproteobacteria,43S5W@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_1605478_1	686340.Metal_3276	4.23e-20	84.3	2DKVG@1|root,30GRY@2|Bacteria,1RDQT@1224|Proteobacteria,1S80C@1236|Gammaproteobacteria,1XFEZ@135618|Methylococcales	135618|Methylococcales	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
k59_1605478_2	525318.HMPREF0497_2571	2.86e-05	48.5	COG1220@1|root,COG1220@2|Bacteria,1TPKQ@1239|Firmicutes,4HA83@91061|Bacilli,3F3WB@33958|Lactobacillaceae	91061|Bacilli	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_197841_1	335543.Sfum_3299	2.19e-92	286.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,42M3R@68525|delta/epsilon subdivisions,2WJGT@28221|Deltaproteobacteria,2MQCY@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
k59_89580_2	1144305.PMI02_02713	2.52e-22	103.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria,2K0P4@204457|Sphingomonadales	204457|Sphingomonadales	M	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1260352_1	765910.MARPU_15375	3.33e-123	366.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1WWIH@135613|Chromatiales	135613|Chromatiales	CP	PFAM NADH Ubiquinone plastoquinone	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
k59_1666138_1	56780.SYN_00316	5.63e-80	253.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,42M0V@68525|delta/epsilon subdivisions,2WIQ1@28221|Deltaproteobacteria,2MQ5I@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	FAD linked oxidase domain protein	glcD	-	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1605487_1	1121405.dsmv_0675	8.68e-77	242.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2WJBH@28221|Deltaproteobacteria,2MJ0H@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_89594_1	1121479.AUBS01000009_gene1479	8.06e-50	170.0	COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,2TSKH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1201395_1	880072.Desac_2726	6.77e-90	275.0	COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42NUN@68525|delta/epsilon subdivisions,2WJHN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Polysulphide reductase, NrfD	dsrP	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_1552286_1	1049564.TevJSym_be00050	4.78e-112	329.0	COG1242@1|root,COG1242@2|Bacteria,1MUYF@1224|Proteobacteria,1RP94@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	radical SAM protein	yhcC	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051539,GO:0051540	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
k59_496181_1	717773.Thicy_0197	2.09e-23	103.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,460HX@72273|Thiotrichales	72273|Thiotrichales	O	FeS assembly protein SufD	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_392480_1	85643.Tmz1t_0386	2.72e-38	137.0	COG3301@1|root,COG3301@2|Bacteria,1MXQ9@1224|Proteobacteria,2VJBF@28216|Betaproteobacteria,2KUPF@206389|Rhodocyclales	206389|Rhodocyclales	P	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
k59_392480_2	497321.C664_07278	4.59e-100	314.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,2KVC6@206389|Rhodocyclales	206389|Rhodocyclales	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_920854_1	1255043.TVNIR_2107	1.82e-05	52.0	COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,1RMJ1@1236|Gammaproteobacteria,1WX3N@135613|Chromatiales	135613|Chromatiales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_integrase
k59_42026_1	1267005.KB911258_gene40	8.05e-52	173.0	COG0382@1|root,COG0382@2|Bacteria,1MVS1@1224|Proteobacteria,2TVKN@28211|Alphaproteobacteria,3N89Q@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	UbiA prenyltransferase family	bchG	-	2.5.1.133,2.5.1.62	ko:K04040	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06284,R09067,R11514,R11517	RC00020	ko00000,ko00001,ko01000,ko01006	-	-	-	UbiA
k59_42026_2	1150469.RSPPHO_00052	8.78e-35	130.0	COG2211@1|root,COG2211@2|Bacteria,1MWE4@1224|Proteobacteria,2TQY7@28211|Alphaproteobacteria,2JQEP@204441|Rhodospirillales	204441|Rhodospirillales	G	PUCC protein	-	-	-	ko:K08226	-	-	-	-	ko00000,ko02000	2.A.1.41	-	-	PUCC
k59_979966_1	153948.NAL212_3117	1.11e-95	307.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2VJSI@28216|Betaproteobacteria,372PZ@32003|Nitrosomonadales	28216|Betaproteobacteria	L	RNA polymerase recycling family C-terminal	-	-	-	ko:K03580	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	DUF3883,Helicase_C,RapA_C,ResIII,SNF2_N
k59_1267132_3	987059.RBXJA2T_15728	0.000548	44.7	COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,2VJBG@28216|Betaproteobacteria,1KPDV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	qseC	-	2.7.13.3	ko:K07645	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
k59_1729606_1	483215.BACFIN_06067	1.2e-07	57.8	COG0702@1|root,COG0702@2|Bacteria,4PMUE@976|Bacteroidetes,2G0GH@200643|Bacteroidia,4AV7T@815|Bacteroidaceae	976|Bacteroidetes	GM	Pfam:SusD	-	-	-	ko:K21572	-	-	-	-	ko00000,ko02000	8.A.46.1,8.A.46.3	-	-	SusD-like_3,SusD_RagB
k59_100300_1	5286.M7WPL4	1.26e-05	51.2	COG2335@1|root,KOG1437@2759|Eukaryota,39MP0@33154|Opisthokonta,3P0QV@4751|Fungi,3V0PZ@5204|Basidiomycota,2YF6I@29000|Pucciniomycotina	4751|Fungi	MW	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
k59_614237_1	686340.Metal_2693	3.47e-89	271.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,1XE1F@135618|Methylococcales	135618|Methylococcales	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_203829_1	1049564.TevJSym_aj00220	4.82e-34	128.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,1J4NR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0739 Membrane proteins related to metalloendopeptidases	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_100317_1	765910.MARPU_02230	2.42e-67	213.0	COG3128@1|root,COG3128@2|Bacteria,1MUI7@1224|Proteobacteria,1RQ0M@1236|Gammaproteobacteria,1WX61@135613|Chromatiales	135613|Chromatiales	S	PKHD-type hydroxylase	-	-	-	ko:K07336	-	-	-	-	ko00000,ko01000	-	-	-	2OG-FeII_Oxy_3
k59_1553081_1	631362.Thi970DRAFT_02769	2.17e-179	522.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1WW1J@135613|Chromatiales	135613|Chromatiales	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	-	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_1553081_2	95619.PM1_0227090	1.14e-134	394.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	ubiD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	iECO111_1330.ECO111_4669	UbiD
k59_203839_1	1125971.ASJB01000099_gene2283	0.000558	43.9	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria,4DYE1@85010|Pseudonocardiales	201174|Actinobacteria	P	Zn-dependent hydrolase, glyoxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
k59_1377142_2	582744.Msip34_2280	3.32e-49	166.0	2CDCV@1|root,308Y1@2|Bacteria,1N74F@1224|Proteobacteria,2VSMP@28216|Betaproteobacteria,2KMRH@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1377142_3	713586.KB900536_gene654	2.77e-59	188.0	COG1051@1|root,COG1051@2|Bacteria,1N03W@1224|Proteobacteria,1S970@1236|Gammaproteobacteria,1X18A@135613|Chromatiales	135613|Chromatiales	F	Belongs to the Nudix hydrolase family. NudJ subfamily	nudJ	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_849376_1	394503.Ccel_0212	1.19e-53	186.0	COG1274@1|root,COG1274@2|Bacteria,1TQED@1239|Firmicutes,249NP@186801|Clostridia,36F58@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
k59_614255_1	10224.XP_006824200.1	6.66e-15	80.5	2BZ8C@1|root,2S8CX@2759|Eukaryota,3A92Y@33154|Opisthokonta,3BTZA@33208|Metazoa,3DATV@33213|Bilateria	33208|Metazoa	S	Protein rolling stone-like	-	GO:0000768,GO:0005575,GO:0006949,GO:0007520,GO:0008150,GO:0009653,GO:0009987,GO:0014902,GO:0016020,GO:0030154,GO:0032502,GO:0042692,GO:0048646,GO:0048856,GO:0048869,GO:0051146,GO:0061061	-	-	-	-	-	-	-	-	-	-	-
k59_1611245_1	1388763.O165_001955	1.05e-76	239.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1YWXI@136845|Pseudomonas putida group	1236|Gammaproteobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008840,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_2492,iJN746.PP_1237,iYL1228.KPN_02812	DHDPS
k59_276509_1	1165841.SULAR_02878	1.28e-91	285.0	COG3211@1|root,COG3211@2|Bacteria,1NSHF@1224|Proteobacteria	1224|Proteobacteria	S	Phosphatase	-	-	-	ko:K07093	-	-	-	-	ko00000	-	-	-	DUF839
k59_438269_1	56780.SYN_02713	5.02e-89	275.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2MRG9@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1501549_1	326427.Cagg_3310	6.66e-49	169.0	COG1129@1|root,COG1129@2|Bacteria,2G649@200795|Chloroflexi,376BP@32061|Chloroflexia	32061|Chloroflexia	P	ABC transporter	rbsA	-	3.6.3.17	ko:K10562	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.9	-	-	ABC_tran
k59_1501549_2	929712.KI912613_gene3588	8.76e-11	64.7	COG1172@1|root,COG1172@2|Bacteria,2GM6S@201174|Actinobacteria,4CS8A@84995|Rubrobacteria	84995|Rubrobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440,ko:K10560	ko02010,map02010	M00212,M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.9	-	-	BPD_transp_2
k59_1672192_1	1182590.BN5_02130	1.3e-68	222.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1YEFI@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0003674,GO:0003824,GO:0004044,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0034654,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iAF1260.b2312,iB21_1397.B21_02197,iBWG_1329.BWG_2086,iECBD_1354.ECBD_1347,iECB_1328.ECB_02237,iECDH10B_1368.ECDH10B_2474,iECDH1ME8569_1439.ECDH1ME8569_2250,iECD_1391.ECD_02237,iECIAI1_1343.ECIAI1_2389,iECO103_1326.ECO103_2776,iECO111_1330.ECO111_3060,iECO26_1355.ECO26_3300,iECW_1372.ECW_m2501,iEKO11_1354.EKO11_1453,iETEC_1333.ETEC_2448,iEcDH1_1363.EcDH1_1344,iEcE24377_1341.EcE24377A_2606,iEcolC_1368.EcolC_1340,iJO1366.b2312,iJR904.b2312,iSF_1195.SF2388,iSFxv_1172.SFxv_2633,iSSON_1240.SSON_2370,iS_1188.S2523,iSbBS512_1146.SbBS512_E2690,iUMNK88_1353.UMNK88_2863,iWFL_1372.ECW_m2501,iY75_1357.Y75_RS12125	GATase_6,Pribosyltran
k59_1611252_1	243365.CV_2324	3.67e-21	97.8	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VKEQ@28216|Betaproteobacteria,2KPI9@206351|Neisseriales	206351|Neisseriales	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	CHASE,HATPase_c,HisKA,PAS_4
k59_1139740_1	265072.Mfla_2656	1.52e-86	281.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KMDI@206350|Nitrosomonadales	206350|Nitrosomonadales	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K10715	ko02020,ko02024,map02020,map02024	M00517	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Hpt,Response_reg
k59_43402_1	367299.JOEE01000012_gene3231	3.33e-127	376.0	COG0365@1|root,COG0365@2|Bacteria,2GJSQ@201174|Actinobacteria,4FIAW@85021|Intrasporangiaceae	201174|Actinobacteria	I	AMP-binding enzyme C-terminal domain	acsA4	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_732136_1	1269813.ATUL01000017_gene2552	8.45e-205	583.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales	135613|Chromatiales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1377168_1	28072.Nos7524_5048	1.25e-27	117.0	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG2203@1|root,COG2905@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2905@2|Bacteria,1G09B@1117|Cyanobacteria,1HKS3@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_145304_1	396588.Tgr7_3057	4.14e-103	321.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales	135613|Chromatiales	I	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_1729656_1	414684.RC1_4088	4.13e-37	140.0	COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2TUZZ@28211|Alphaproteobacteria,2JTMG@204441|Rhodospirillales	204441|Rhodospirillales	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_1729656_2	1042377.AFPJ01000054_gene1715	6.42e-71	232.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,1RRN4@1236|Gammaproteobacteria,4674P@72275|Alteromonadaceae	1236|Gammaproteobacteria	EU	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
k59_1611266_1	335543.Sfum_1627	2.07e-40	156.0	COG0668@1|root,COG0668@2|Bacteria,1MY0I@1224|Proteobacteria,42PJV@68525|delta/epsilon subdivisions,2WKRG@28221|Deltaproteobacteria,2MS2C@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
k59_1267201_1	1123514.KB905900_gene2089	1.31e-40	153.0	COG0526@1|root,COG0526@2|Bacteria,1RCTX@1224|Proteobacteria,1S4XW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CO	Thioredoxin	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
k59_1021166_1	1150599.MPHLEI_04687	2.95e-48	164.0	COG1946@1|root,COG1946@2|Bacteria,2I7KM@201174|Actinobacteria,237M9@1762|Mycobacteriaceae	201174|Actinobacteria	I	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
k59_1092972_1	1304865.JAGF01000001_gene3141	3.74e-156	472.0	COG1038@1|root,COG1038@2|Bacteria,2H238@201174|Actinobacteria,4F1VZ@85016|Cellulomonadaceae	201174|Actinobacteria	C	Conserved carboxylase domain	pyc	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA
k59_1333605_1	404380.Gbem_1881	2.34e-18	89.4	COG2010@1|root,COG2010@2|Bacteria,1QXNT@1224|Proteobacteria,430N9@68525|delta/epsilon subdivisions,2WVNM@28221|Deltaproteobacteria,43VA1@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_321221_1	265072.Mfla_0139	1.25e-20	92.4	COG3117@1|root,COG3117@2|Bacteria,1R5UK@1224|Proteobacteria,2VU37@28216|Betaproteobacteria,2KMR4@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Lipopolysaccharide-assembly, LptC-related	-	-	-	ko:K11719	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC
k59_321221_2	1122951.ATUE01000008_gene4	2.61e-06	49.7	COG1934@1|root,COG1934@2|Bacteria,1N3J5@1224|Proteobacteria,1SBBI@1236|Gammaproteobacteria,3NJF1@468|Moraxellaceae	1236|Gammaproteobacteria	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
k59_145312_1	1217718.ALOU01000066_gene1948	2.22e-24	101.0	COG3637@1|root,COG3637@2|Bacteria,1N7IC@1224|Proteobacteria,2VVZ0@28216|Betaproteobacteria,1K72N@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	pagL	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008653,GO:0009279,GO:0009311,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0016788,GO:0019637,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0042802,GO:0042803,GO:0043170,GO:0044237,GO:0044238,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044425,GO:0044462,GO:0044464,GO:0046493,GO:0046983,GO:0050528,GO:0052689,GO:0071704,GO:0071944,GO:1901135,GO:1901269,GO:1903509	-	ko:K12976	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	PagL
k59_1787001_1	1479239.JQMU01000001_gene415	4.59e-49	177.0	COG1629@1|root,COG4771@2|Bacteria,1R533@1224|Proteobacteria,2TVP0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_1333611_1	1123236.KB899376_gene965	3.03e-36	131.0	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,464W3@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex	ccoP	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	iJN746.PP_4253	Cytochrome_CBB3,FixP_N
k59_1333611_2	1384056.N787_07055	7.33e-53	181.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1X4FV@135614|Xanthomonadales	135614|Xanthomonadales	C	IG-like fold at C-terminal of FixG, putative oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
k59_673610_1	1429851.X548_04565	2.95e-24	105.0	28JVJ@1|root,2Z9KI@2|Bacteria,1QFFA@1224|Proteobacteria,1TCPH@1236|Gammaproteobacteria,1X9NB@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_438306_1	1395571.TMS3_0121875	2.74e-40	138.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1RNU8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the SUA5 family	yciO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
k59_438306_2	768671.ThimaDRAFT_2027	1.5e-34	127.0	COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,1RNCG@1236|Gammaproteobacteria,1WXKB@135613|Chromatiales	135613|Chromatiales	S	pfam php	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
k59_1021181_2	1317118.ATO8_07846	1.06e-06	51.2	2D1C5@1|root,32TAD@2|Bacteria,1N23F@1224|Proteobacteria,2U94F@28211|Alphaproteobacteria,4KNK4@93682|Roseivivax	28211|Alphaproteobacteria	S	Ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase
k59_555637_1	880072.Desac_1556	4.85e-118	353.0	COG0151@1|root,COG0151@2|Bacteria,1NTMF@1224|Proteobacteria,42YB9@68525|delta/epsilon subdivisions,2WTMZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain	-	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A
k59_1861934_1	880072.Desac_0436	1.95e-90	288.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1QFX3@1224|Proteobacteria,42PIP@68525|delta/epsilon subdivisions,2WKWI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM pyruvate phosphate dikinase, PEP pyruvate-binding	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_438310_1	177437.HRM2_33940	1.94e-55	193.0	COG5421@1|root,COG5421@2|Bacteria,1R25F@1224|Proteobacteria,433HE@68525|delta/epsilon subdivisions,2WYHG@28221|Deltaproteobacteria,2MP7M@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Domain of unknown function (DUF4277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4277
k59_1092999_1	357804.Ping_0802	2.96e-28	104.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria,2QIBM@267894|Psychromonadaceae	1236|Gammaproteobacteria	S	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_321237_1	502025.Hoch_6599	1e-60	199.0	COG0287@1|root,COG1605@1|root,COG0287@2|Bacteria,COG1605@2|Bacteria,1QA4K@1224|Proteobacteria,42V3B@68525|delta/epsilon subdivisions,2WRIN@28221|Deltaproteobacteria,2YW0I@29|Myxococcales	28221|Deltaproteobacteria	E	Prephenate dehydrogenase chorismate mutase	-	-	1.3.1.12	ko:K00210	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,PDH
k59_786354_1	1408473.JHXO01000010_gene3635	2.26e-15	81.3	COG1404@1|root,COG1404@2|Bacteria,4NI53@976|Bacteroidetes,2FV8D@200643|Bacteroidia	976|Bacteroidetes	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,Peptidase_S8
k59_43468_1	582899.Hden_1402	3.8e-14	75.5	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TSUW@28211|Alphaproteobacteria,3N66V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Domain of unknown function (DUF1974)	fadE	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_849433_1	563040.Saut_1279	6.91e-38	145.0	COG1615@1|root,COG1615@2|Bacteria,1MZ5A@1224|Proteobacteria,42M4M@68525|delta/epsilon subdivisions,2YR7N@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_1861938_1	1049564.TevJSym_ad00290	1.28e-88	290.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,1J980@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2309)	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k59_145342_1	2340.JV46_13060	3.61e-79	247.0	COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,1RQ0T@1236|Gammaproteobacteria,1J5E5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	ldh	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_1333650_1	1089455.MOPEL_010_00010	1.64e-193	550.0	COG3385@1|root,COG3385@2|Bacteria,2H68X@201174|Actinobacteria,4F7DH@85018|Dermatophilaceae	201174|Actinobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_1729702_1	1429046.RR21198_6001	3.36e-68	226.0	COG1201@1|root,COG1201@2|Bacteria,2GK56@201174|Actinobacteria,4FY31@85025|Nocardiaceae	201174|Actinobacteria	L	helicase superfamily c-terminal domain	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C
k59_1501632_1	667014.Thein_1253	5.96e-60	206.0	COG3829@1|root,COG3829@2|Bacteria,2GHKK@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	KT	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_9,Sigma54_activat
k59_981467_1	1111069.TCCBUS3UF1_600	2.57e-07	58.5	COG4974@1|root,COG4974@2|Bacteria,1WJFE@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
k59_1437349_1	1116472.MGMO_152c00050	1.44e-90	288.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1XEQR@135618|Methylococcales	135618|Methylococcales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_1093015_1	521719.ATXQ01000001_gene617	9.28e-111	326.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,1YEMW@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Branched-chain amino acid ATP-binding cassette transporter	lptB	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
k59_1093015_2	930166.CD58_04605	1.75e-186	537.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_1093015_3	1268239.PALB_12530	2.6e-40	135.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,2Q2QC@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	J	COG1544 Ribosome-associated protein Y (PSrp-1)	yhbH	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
k59_1333671_1	393595.ABO_1030	1.6e-75	231.0	COG1573@1|root,COG1573@2|Bacteria,1R9XV@1224|Proteobacteria,1S20R@1236|Gammaproteobacteria,1XJH8@135619|Oceanospirillales	135619|Oceanospirillales	L	Uracil-DNA glycosylase	-	-	-	-	-	-	-	-	-	-	-	-	UDG
k59_393977_1	1035308.AQYY01000001_gene3286	4.23e-78	254.0	COG0651@1|root,COG0651@2|Bacteria,1TS67@1239|Firmicutes,24DZG@186801|Clostridia,266YF@186807|Peptococcaceae	186801|Clostridia	C	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_438341_1	335543.Sfum_1179	1.57e-101	310.0	COG1148@1|root,COG1148@2|Bacteria,1PZ04@1224|Proteobacteria,42PT3@68525|delta/epsilon subdivisions,2WMJU@28221|Deltaproteobacteria,2MR5J@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	FAD dependent oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2
k59_922407_1	1485545.JQLW01000007_gene839	1.13e-51	184.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria	1224|Proteobacteria	L	Atp-dependent helicase	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_282499_2	69279.BG36_01060	2.38e-41	148.0	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,2TS5P@28211|Alphaproteobacteria,43J5S@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	VWA domain containing CoxE-like protein	MA20_01305	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
k59_49799_1	1121015.N789_08285	3.05e-93	289.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1X9T5@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_853681_1	497964.CfE428DRAFT_4840	6.47e-39	143.0	COG0606@1|root,COG0606@2|Bacteria,46SAK@74201|Verrucomicrobia	74201|Verrucomicrobia	O	PFAM magnesium chelatase ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_988658_1	177437.HRM2_31590	1.74e-43	158.0	COG0664@1|root,COG0664@2|Bacteria,1R8R8@1224|Proteobacteria,42PH6@68525|delta/epsilon subdivisions,2WKQJ@28221|Deltaproteobacteria,2MJ5X@213118|Desulfobacterales	28221|Deltaproteobacteria	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_929510_1	743718.Isova_1657	1.66e-68	216.0	COG0311@1|root,COG0311@2|Bacteria,2GNYG@201174|Actinobacteria,4F376@85017|Promicromonosporaceae	201174|Actinobacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
k59_736749_1	479431.Namu_4067	1.47e-29	115.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4EV59@85013|Frankiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_559887_2	765912.Thimo_3113	1.37e-46	164.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1WWI1@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_401100_1	439235.Dalk_3112	1.61e-48	167.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,1RGKE@1224|Proteobacteria,42QI9@68525|delta/epsilon subdivisions,2WIV3@28221|Deltaproteobacteria,2MI92@213118|Desulfobacterales	28221|Deltaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD,Lactamase_B_2
k59_49825_1	1279015.KB908454_gene687	1.33e-78	250.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1Y43R@135624|Aeromonadales	135624|Aeromonadales	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
k59_1557425_1	744979.R2A130_1410	4.82e-37	140.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2TRU8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0433 Predicted ATPase	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
k59_559891_2	1117647.M5M_04600	6.88e-110	343.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVS@1236|Gammaproteobacteria,1J55S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA
k59_988683_1	381666.H16_A1282	5.61e-20	89.0	COG1163@1|root,COG1163@2|Bacteria,1RFPD@1224|Proteobacteria,2VZKC@28216|Betaproteobacteria,1KBNU@119060|Burkholderiaceae	28216|Betaproteobacteria	S	TGS domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,TGS
k59_988683_2	324602.Caur_1212	2.65e-27	113.0	COG0474@1|root,COG0474@2|Bacteria,2G5ZS@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_1143484_1	933262.AXAM01000018_gene1019	5.66e-134	399.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2WINJ@28221|Deltaproteobacteria,2MHY9@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_618538_1	342113.DM82_6201	8.53e-27	114.0	COG4409@1|root,COG4409@2|Bacteria,1Q513@1224|Proteobacteria,2WB3C@28216|Betaproteobacteria,1K536@119060|Burkholderiaceae	28216|Betaproteobacteria	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR,BNR_2
k59_49856_1	1504319.GM45_5810	2.5e-40	151.0	COG0768@1|root,COG0768@2|Bacteria,2GJ61@201174|Actinobacteria,3UXBI@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Penicillin-binding Protein dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	FTSW_RODA_SPOVE,PBP_dimer,Transpeptidase
k59_282556_1	1500893.JQNB01000001_gene1603	1.64e-78	245.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1X4E4@135614|Xanthomonadales	135614|Xanthomonadales	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_1790802_1	545694.TREPR_0130	2.28e-37	140.0	COG0265@1|root,COG0265@2|Bacteria,2J6JY@203691|Spirochaetes	203691|Spirochaetes	O	COGs COG0265 Trypsin-like serine protease typically periplasmic contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
k59_1340911_1	1123251.ATWM01000010_gene2987	4.41e-31	110.0	COG4327@1|root,COG4327@2|Bacteria,2IRIC@201174|Actinobacteria,4FJA9@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4212)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4212
k59_1340911_2	1146883.BLASA_0192	7.04e-39	135.0	2E13N@1|root,32WJ1@2|Bacteria,2IRAG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1676653_1	465541.ATCJ01000005_gene6903	3.64e-20	95.5	COG4249@1|root,COG4249@2|Bacteria,2IB3R@201174|Actinobacteria	201174|Actinobacteria	M	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
k59_282560_1	1089455.MOPEL_130_01700	1.63e-88	271.0	COG0192@1|root,COG0192@2|Bacteria,2GJ4U@201174|Actinobacteria,4F691@85018|Dermatophilaceae	201174|Actinobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_1381637_1	768671.ThimaDRAFT_2338	1.07e-112	333.0	COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1MV72@1224|Proteobacteria,1RPH5@1236|Gammaproteobacteria,1WXHI@135613|Chromatiales	135613|Chromatiales	C	Oxidoreductase FAD-binding domain	-	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
k59_149831_1	243233.MCA0045	7.37e-78	240.0	COG1515@1|root,COG1515@2|Bacteria,1MWRN@1224|Proteobacteria,1RRYH@1236|Gammaproteobacteria,1XG9S@135618|Methylococcales	135618|Methylococcales	L	Endonuclease V	-	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
k59_1097771_1	1394178.AWOO02000041_gene8808	2.15e-44	162.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4EMPS@85012|Streptosporangiales	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
k59_1340921_1	41431.PCC8801_3084	1.41e-14	75.9	COG0628@1|root,COG0628@2|Bacteria,1G26W@1117|Cyanobacteria,3KG14@43988|Cyanothece	1117|Cyanobacteria	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1506591_1	471853.Bcav_3818	7.73e-56	196.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,2GIT4@201174|Actinobacteria	201174|Actinobacteria	CP	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit	mrpA/mrpB	-	-	ko:K05565,ko:K14086	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
k59_1869167_1	626887.J057_18835	5.46e-33	131.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,46516@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
k59_1557451_1	680198.SCAB_6911	4.77e-68	216.0	COG0294@1|root,COG0294@2|Bacteria,2GJDQ@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
k59_1272262_1	1265313.HRUBRA_00209	3.26e-21	97.4	COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,1S52W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C
k59_853722_2	999611.KI421504_gene88	1.32e-32	119.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2TQYF@28211|Alphaproteobacteria,27ZH8@191028|Leisingera	28211|Alphaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10,Fer4_17,Fer4_8
k59_442679_1	1380356.JNIK01000013_gene3933	1.49e-41	160.0	COG2197@1|root,COG3899@1|root,COG2197@2|Bacteria,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,GerE,Trans_reg_C
k59_325571_1	2340.JV46_10170	5.55e-21	90.1	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,1J545@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex	ccoP	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	iJN746.PP_4253	Cytochrome_CBB3,FixP_N
k59_325571_2	384676.PSEEN1800	6.67e-14	65.9	COG4736@1|root,COG4736@2|Bacteria	2|Bacteria	O	Cbb3-type cytochrome oxidase	ccoQ	-	-	ko:K00407	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixQ
k59_325571_3	998674.ATTE01000001_gene4154	8.52e-99	291.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,1RPU6@1236|Gammaproteobacteria,460P4@72273|Thiotrichales	72273|Thiotrichales	C	TIGRFAM cytochrome c oxidase, cbb3-type, subunit II	-	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
k59_618561_1	933262.AXAM01000039_gene1156	1.68e-89	275.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,2MHWD@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	type II secretion system	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_501355_1	1122915.AUGY01000012_gene3943	1.14e-79	253.0	COG4584@1|root,COG4584@2|Bacteria,1TR5X@1239|Firmicutes,4HBD9@91061|Bacilli,26U5V@186822|Paenibacillaceae	91061|Bacilli	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1381659_1	443152.MDG893_09696	8.33e-47	157.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,464RA@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008289,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009628,GO:0009651,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0042538,GO:0043167,GO:0043168,GO:0043431,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901611,GO:1901661,GO:1901663	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	iE2348C_1286.E2348C_2376	Methyltransf_23
k59_1381659_2	1316936.K678_09106	4.2e-06	48.9	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,2U79T@28211|Alphaproteobacteria,2JSSB@204441|Rhodospirillales	204441|Rhodospirillales	S	Phosphoglycolate phosphatase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_929602_1	1156919.QWC_24005	2.74e-14	71.2	COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,2VJ6G@28216|Betaproteobacteria,3T3D2@506|Alcaligenaceae	28216|Betaproteobacteria	S	Carboxylesterase	estB	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
k59_929602_2	1469245.JFBG01000087_gene1681	2.69e-35	132.0	COG3332@1|root,COG3332@2|Bacteria,1RDBS@1224|Proteobacteria,1S43Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Transport and Golgi organisation 2	-	-	-	-	-	-	-	-	-	-	-	-	TANGO2
k59_559933_1	1385519.N801_05265	2.79e-56	189.0	COG2021@1|root,COG2021@2|Bacteria,2IMKC@201174|Actinobacteria,4FINJ@85021|Intrasporangiaceae	201174|Actinobacteria	E	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Hydrolase_4
k59_501359_2	748658.KB907312_gene1395	1.77e-39	140.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1WWRK@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
k59_149866_1	522306.CAP2UW1_0062	1.53e-62	205.0	COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,2WGS2@28216|Betaproteobacteria,1KR4T@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_49923_1	340099.Teth39_1044	1.64e-113	347.0	COG5012@1|root,COG5012@2|Bacteria,1UHX7@1239|Firmicutes,25E66@186801|Clostridia,42FDG@68295|Thermoanaerobacterales	186801|Clostridia	S	D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit	oraE	-	5.4.3.5	ko:K17898	ko00472,map00472	-	R02461	RC00719	ko00000,ko00001,ko01000	-	-	-	B12-binding,Lys-AminoMut_A,OAM_dimer
k59_1024860_1	1170318.PALO_11000	2.6e-20	89.7	COG0115@1|root,COG0115@2|Bacteria,2GN5Z@201174|Actinobacteria	201174|Actinobacteria	EH	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	pabC	-	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	-	Aminotran_4
k59_1024860_2	1043493.BBLU01000007_gene129	1.08e-83	270.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,2H7WY@201174|Actinobacteria	201174|Actinobacteria	P	oxidoreductase	cdr	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
k59_49929_1	743718.Isova_2183	6.05e-155	452.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4F3GP@85017|Promicromonosporaceae	201174|Actinobacteria	H	PFAM thiamine pyrophosphate protein TPP binding domain protein	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_559943_1	1433287.X808_12660	2.25e-19	87.8	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1Y7YN@135625|Pasteurellales	135625|Pasteurellales	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_559943_2	1286106.MPL1_09872	1.66e-14	71.2	COG4969@1|root,COG4969@2|Bacteria,1N71K@1224|Proteobacteria,1SCYD@1236|Gammaproteobacteria,461I7@72273|Thiotrichales	72273|Thiotrichales	NU	Domain of unknown function (DUF4845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4845,N_methyl
k59_1441721_1	743718.Isova_2719	1.83e-65	211.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4F3JS@85017|Promicromonosporaceae	201174|Actinobacteria	E	ACT domain	ask	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
k59_1441721_2	471853.Bcav_0560	4.15e-07	51.6	COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3708c	Semialdhyde_dh,Semialdhyde_dhC
k59_501368_1	312284.A20C1_05796	6.44e-05	50.1	COG1172@1|root,COG1172@2|Bacteria,2I5GY@201174|Actinobacteria,3UXSS@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_282637_1	1121405.dsmv_1967	5.32e-86	272.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MMTC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.12.1.3,1.6.5.3	ko:K00124,ko:K00335,ko:K05587,ko:K18331	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_282637_2	1121405.dsmv_1966	1.27e-75	231.0	COG3383@1|root,COG3383@2|Bacteria	2|Bacteria	C	formate dehydrogenase (NAD+) activity	-	-	1.17.1.9,1.6.5.3	ko:K00123,ko:K00336	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_21,NADH-G_4Fe-4S_3
k59_618581_1	472759.Nhal_2768	3.57e-120	354.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,1WWET@135613|Chromatiales	135613|Chromatiales	E	PFAM Aminotransferase class I and II	-	-	2.6.1.17	ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1207296_1	981384.AEYW01000028_gene4248	3.83e-75	241.0	2F138@1|root,33U4R@2|Bacteria,1NUMP@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1507453_1	946483.Cenrod_2496	2.17e-39	144.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2W3RM@28216|Betaproteobacteria,4AJVP@80864|Comamonadaceae	28216|Betaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1507453_2	1123257.AUFV01000014_gene3454	5.47e-47	157.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1X6BF@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1616530_1	1254432.SCE1572_04460	1.62e-103	322.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,42MFA@68525|delta/epsilon subdivisions,2WJ20@28221|Deltaproteobacteria,2YU4B@29|Myxococcales	28221|Deltaproteobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_502080_1	1304284.L21TH_0107	2.54e-82	263.0	COG0366@1|root,COG0366@2|Bacteria,1TR93@1239|Firmicutes,24AB0@186801|Clostridia,36FBK@31979|Clostridiaceae	186801|Clostridia	G	Sucrose phosphorylase	-	-	2.4.1.329,2.4.1.7	ko:K00690,ko:K21350	ko00500,map00500	-	R00803	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
k59_790540_1	402881.Plav_2312	1.05e-12	64.3	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria,1JNVJ@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_790540_2	1123229.AUBC01000033_gene3561	1.05e-62	201.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2TRBW@28211|Alphaproteobacteria,3JRYT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_209153_1	1454004.AW11_02845	4.65e-52	177.0	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,2VPFR@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_209153_2	765912.Thimo_3333	1.69e-18	79.0	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,1WYMA@135613|Chromatiales	135613|Chromatiales	O	Belongs to the glutaredoxin family. Monothiol subfamily	-	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
k59_1025470_2	1232410.KI421421_gene3631	1.77e-45	164.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,42MNS@68525|delta/epsilon subdivisions,2WSQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	MFS_1,TLC
k59_443460_1	367299.JOEE01000002_gene2227	4.79e-109	326.0	COG0415@1|root,COG0415@2|Bacteria,2GJXU@201174|Actinobacteria,4FEJD@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the DNA photolyase family	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_108850_1	765910.MARPU_06360	7.27e-95	307.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales	135613|Chromatiales	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_1616554_1	987059.RBXJA2T_11643	3.72e-97	300.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2VGZ9@28216|Betaproteobacteria,1KK5E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_854547_1	1118235.CAJH01000019_gene1037	1.19e-33	132.0	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,1RMC2@1236|Gammaproteobacteria,1X3M4@135614|Xanthomonadales	135614|Xanthomonadales	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004721,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009987,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0017076,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
k59_1025487_2	396588.Tgr7_2908	2.34e-66	207.0	COG4769@1|root,COG4769@2|Bacteria,1RJIB@1224|Proteobacteria,1SBYC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Heptaprenyl diphosphate synthase component I	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	Hpre_diP_synt_I
k59_1025487_3	1415754.JQMK01000013_gene419	8.82e-10	62.0	COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,1S3A6@1236|Gammaproteobacteria,465SW@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0810 Periplasmic protein TonB, links inner and outer membranes	tonB3	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
k59_737629_1	525146.Ddes_1546	2.71e-15	80.5	COG0247@1|root,COG0277@1|root,COG0479@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG0479@2|Bacteria,1MU6Y@1224|Proteobacteria,42M5I@68525|delta/epsilon subdivisions,2WK8Y@28221|Deltaproteobacteria,2M91E@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	FAD linked oxidase domain protein	-	-	-	ko:K18930	-	-	-	-	ko00000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8
k59_1616561_1	1120977.JHUX01000003_gene655	1.66e-08	66.6	COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,3NII0@468|Moraxellaceae	1236|Gammaproteobacteria	T	Signal transducing histidine kinase, homodimeric domain	chpA	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_50981_1	1123399.AQVE01000001_gene680	1.46e-23	99.0	COG3658@1|root,COG3658@2|Bacteria,1N28F@1224|Proteobacteria,1S2S2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	PFAM Di-haem cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	DHC
k59_679003_2	748280.NH8B_3097	3.81e-31	119.0	2E5SP@1|root,330H2@2|Bacteria,1NDBY@1224|Proteobacteria,2VXDV@28216|Betaproteobacteria	28216|Betaproteobacteria	S	YMGG-like Gly-zipper	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_OmpA,Gly-zipper_YMGG
k59_1507503_1	1304865.JAGF01000001_gene2884	1.06e-16	87.0	COG5602@1|root,COG5602@2|Bacteria	2|Bacteria	B	histone deacetylation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1342167_1	1304865.JAGF01000001_gene2558	8.87e-24	107.0	COG1674@1|root,COG1674@2|Bacteria,2GJBR@201174|Actinobacteria,4F20I@85016|Cellulomonadaceae	201174|Actinobacteria	D	FtsK/SpoIIIE family	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FHA,FtsK_SpoIIIE
k59_854563_1	880072.Desac_0671	1.88e-98	296.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,42N9Q@68525|delta/epsilon subdivisions,2WIK1@28221|Deltaproteobacteria,2MRGN@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_108882_1	573569.F7308_0577	1.12e-18	87.8	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,45ZNN@72273|Thiotrichales	72273|Thiotrichales	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_108882_2	1265503.KB905165_gene1132	3.89e-30	119.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,2Q5ZC@267889|Colwelliaceae	1236|Gammaproteobacteria	C	2-oxoglutarate dehydrogenase N-terminus	sucA	GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_443494_1	482537.XP_008571878.1	6.39e-21	98.2	COG5640@1|root,KOG3627@2759|Eukaryota,39ZFT@33154|Opisthokonta,3BKWW@33208|Metazoa,3D4TJ@33213|Bilateria,48979@7711|Chordata,493X4@7742|Vertebrata,3J5MV@40674|Mammalia,35KDT@314146|Euarchontoglires	33208|Metazoa	E	Trypsin-like serine protease	PRSS44	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	Trypsin
k59_989970_1	1265505.ATUG01000001_gene3952	2.12e-13	70.1	COG1149@1|root,COG1149@2|Bacteria,1MVPB@1224|Proteobacteria,42MJ5@68525|delta/epsilon subdivisions,2WJ9M@28221|Deltaproteobacteria,2MIKP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	CobQ CobB MinD ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
k59_989970_2	56780.SYN_01180	1.37e-59	185.0	COG1433@1|root,COG1433@2|Bacteria,1RDPR@1224|Proteobacteria,42SR6@68525|delta/epsilon subdivisions,2WPP8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Dinitrogenase iron-molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
k59_1101868_1	396588.Tgr7_2014	3.87e-130	379.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1WW43@135613|Chromatiales	135613|Chromatiales	J	TIGRFAM Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_1346516_1	765912.Thimo_1301	2.67e-99	299.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,1WWZH@135613|Chromatiales	135613|Chromatiales	EH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_740645_1	1232410.KI421421_gene3489	8.91e-57	190.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,42MY5@68525|delta/epsilon subdivisions,2WKST@28221|Deltaproteobacteria,43UAH@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Peptidase dimerisation domain	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_740645_2	1121918.ARWE01000001_gene2427	4.79e-44	149.0	COG0454@1|root,COG0456@2|Bacteria,1RF31@1224|Proteobacteria,42RUB@68525|delta/epsilon subdivisions,2WN97@28221|Deltaproteobacteria,43UM1@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1619565_1	575540.Isop_2440	7.32e-50	169.0	28HHC@1|root,2Z7T2@2|Bacteria,2J15Z@203682|Planctomycetes	203682|Planctomycetes	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_24
k59_287794_1	765911.Thivi_4323	3.22e-98	298.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1WWDA@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA	rlmD	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_1737758_1	1121935.AQXX01000144_gene4343	3.76e-16	79.0	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,1RN0G@1236|Gammaproteobacteria,1XP31@135619|Oceanospirillales	135619|Oceanospirillales	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_54948_1	1182590.BN5_00639	7.68e-10	60.5	COG2211@1|root,COG2211@2|Bacteria,1QTSE@1224|Proteobacteria,1SK1A@1236|Gammaproteobacteria,1YKRM@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	G	Acetyl-coenzyme A transporter 1	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
k59_54948_2	396588.Tgr7_0109	3.26e-103	304.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Exodeoxyribonuclease III	crc	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_153746_1	1125863.JAFN01000001_gene2045	4.56e-64	213.0	COG0591@1|root,COG0591@2|Bacteria,1PG9B@1224|Proteobacteria,42N4W@68525|delta/epsilon subdivisions,2WKGC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_792915_1	1713.JOFV01000019_gene1129	1.64e-182	521.0	COG1139@1|root,COG1139@2|Bacteria,2GJDR@201174|Actinobacteria,4F0UF@85016|Cellulomonadaceae	201174|Actinobacteria	C	LUD domain	lutB	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
k59_505151_1	1110697.NCAST_06_00360	2.64e-05	48.1	COG1846@1|root,COG1846@2|Bacteria,2IHTR@201174|Actinobacteria,4G2MM@85025|Nocardiaceae	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR_2
k59_740660_1	698758.AXY_12480	7.17e-34	130.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,4HBHZ@91061|Bacilli	91061|Bacilli	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_1385607_1	1454010.JEOE01000041_gene919	1.05e-66	229.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,2GN0J@201174|Actinobacteria	201174|Actinobacteria	E	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_1,CP_ATPgrasp_2
k59_563701_1	1122933.JNIY01000004_gene2539	1.32e-23	97.1	2BJAR@1|root,32DKN@2|Bacteria,2GR4T@201174|Actinobacteria,4F1BV@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1510710_1	1123065.ATWL01000007_gene3331	3.64e-186	527.0	COG0304@1|root,COG0304@2|Bacteria,2GIY4@201174|Actinobacteria	201174|Actinobacteria	IQ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1346556_1	1713.JOFV01000025_gene1726	3.79e-32	122.0	COG1249@1|root,COG1249@2|Bacteria,2GJJK@201174|Actinobacteria,4F2B5@85016|Cellulomonadaceae	201174|Actinobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	merA	-	1.16.1.1	ko:K00520	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1346556_2	1713.JOFV01000025_gene1727	1.17e-53	169.0	COG0789@1|root,COG0789@2|Bacteria,2IMEG@201174|Actinobacteria,4F2P3@85016|Cellulomonadaceae	201174|Actinobacteria	K	MerR, DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind,MerR_1
k59_1346558_1	123899.JPQP01000004_gene561	2.1e-77	240.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2VHM8@28216|Betaproteobacteria,3T1T0@506|Alcaligenaceae	28216|Betaproteobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
k59_792927_1	1150626.PHAMO_270163	1.31e-18	90.1	COG3203@1|root,COG3203@2|Bacteria,1MWEA@1224|Proteobacteria,2U1TZ@28211|Alphaproteobacteria,2JRUA@204441|Rhodospirillales	204441|Rhodospirillales	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
k59_1737778_1	1121405.dsmv_1320	8.88e-107	334.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MIZ3@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1210100_1	296591.Bpro_0809	6.04e-37	131.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2VHY0@28216|Betaproteobacteria,4AA0X@80864|Comamonadaceae	28216|Betaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_1210100_2	351348.Maqu_3418	1.69e-65	202.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,4679A@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_5014	PRA-CH,PRA-PH
k59_55812_2	383372.Rcas_2210	2.46e-16	74.3	COG3654@1|root,COG3654@2|Bacteria,2GB61@200795|Chloroflexi,377EA@32061|Chloroflexia	32061|Chloroflexia	S	Fic/DOC family	-	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
k59_793457_1	439235.Dalk_0565	3.22e-100	306.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2MHS6@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_935759_1	933262.AXAM01000034_gene1559	9.97e-99	304.0	COG0664@1|root,COG0664@2|Bacteria,1R8R8@1224|Proteobacteria,42PH6@68525|delta/epsilon subdivisions,2WKQJ@28221|Deltaproteobacteria,2MJ5X@213118|Desulfobacterales	28221|Deltaproteobacteria	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_995007_1	356851.JOAN01000014_gene1984	5.8e-101	326.0	2EX5R@1|root,33QGS@2|Bacteria,2ISYT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1738501_1	335543.Sfum_0367	2.11e-108	322.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,2MQ9B@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_741378_1	1033802.SSPSH_002856	3.98e-51	185.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	P-type atpase	ccoI	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_1445949_1	670307.HYPDE_27863	7.6e-37	136.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_55813_1	396588.Tgr7_2123	0.0	939.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1WXIB@135613|Chromatiales	135613|Chromatiales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_114160_1	301.JNHE01000040_gene85	6.02e-18	79.7	2E7KC@1|root,3322E@2|Bacteria,1NBFM@1224|Proteobacteria,1SDU2@1236|Gammaproteobacteria,1YGC6@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Multidrug transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_114160_2	95619.PM1_0202865	3.84e-18	83.2	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Stress-induced protein	yicC	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
k59_1386212_1	263358.VAB18032_19050	2.3e-59	196.0	COG3025@1|root,COG3025@2|Bacteria,2II2C@201174|Actinobacteria,4DCSN@85008|Micromonosporales	201174|Actinobacteria	S	VTC domain	-	-	-	-	-	-	-	-	-	-	-	-	VTC
k59_1386212_2	395494.Galf_1138	3.3e-20	89.4	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2VIHG@28216|Betaproteobacteria,44V68@713636|Nitrosomonadales	28216|Betaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase catalytic region	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_1029712_1	28229.ND2E_0777	3.5e-88	266.0	COG0500@1|root,COG2226@2|Bacteria,1PDVU@1224|Proteobacteria,1RXQY@1236|Gammaproteobacteria,2Q853@267889|Colwelliaceae	1236|Gammaproteobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_55831_1	1267005.KB911260_gene3573	2.9e-32	122.0	COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria,3N676@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	response regulator	pleD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,Response_reg
k59_55831_2	1125973.JNLC01000016_gene2749	2.4e-42	140.0	COG0784@1|root,COG0784@2|Bacteria,1QU3I@1224|Proteobacteria,2TVXW@28211|Alphaproteobacteria,3JY06@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Response regulator receiver domain	divK	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
k59_1347568_1	1049564.TevJSym_ac00130	6.57e-103	318.0	COG4263@1|root,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,1RQSW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide	nosZ	GO:0000041,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0030001,GO:0042597,GO:0044464,GO:0051179,GO:0051234	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	COX2,Cupredoxin_1
k59_1277174_1	1121351.AUAP01000032_gene960	2.39e-08	55.1	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2VIVH@28216|Betaproteobacteria,2KQNC@206351|Neisseriales	206351|Neisseriales	E	creatinase	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
k59_154494_1	1150398.JIBJ01000002_gene1150	2.42e-12	68.2	COG1131@1|root,COG1131@2|Bacteria,2GN8P@201174|Actinobacteria,1WCH5@1268|Micrococcaceae	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_154494_2	1101188.KI912155_gene3608	1.41e-94	285.0	COG1277@1|root,COG1277@2|Bacteria,2GP6D@201174|Actinobacteria,1WB69@1268|Micrococcaceae	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
k59_1029714_1	582402.Hbal_0963	6.44e-98	301.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,43WG3@69657|Hyphomonadaceae	28211|Alphaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1029714_2	1287116.X734_32965	3.54e-12	62.4	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2U9AQ@28211|Alphaproteobacteria,43KDW@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
k59_288656_1	1000565.METUNv1_03611	2.63e-09	62.0	COG2207@1|root,COG2207@2|Bacteria,1Q3UX@1224|Proteobacteria,2VT4I@28216|Betaproteobacteria,2KXSI@206389|Rhodocyclales	206389|Rhodocyclales	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
k59_288656_2	380703.AHA_0503	0.000339	45.4	2DR4R@1|root,33A5Q@2|Bacteria,1NJDG@1224|Proteobacteria,1SH8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_330254_1	991905.SL003B_2352	6.63e-106	327.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2TQZV@28211|Alphaproteobacteria,4BPE0@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_1445968_2	290315.Clim_2386	8.48e-43	145.0	2C8DW@1|root,32RKY@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF3597)	MA20_41375	-	-	-	-	-	-	-	-	-	-	-	DUF3597
k59_1794766_1	525146.Ddes_1543	2.32e-06	50.4	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria,2MGP1@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	sfrB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0055114,GO:0071944	1.17.1.10	ko:K15022	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00377	R00134	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_20,NADH_4Fe-4S,Pyr_redox_2
k59_55837_1	880072.Desac_0433	2.97e-62	197.0	COG0589@1|root,COG0589@2|Bacteria,1N6DC@1224|Proteobacteria,42UXA@68525|delta/epsilon subdivisions,2WQF5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_55837_2	880072.Desac_0432	1.16e-33	123.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like,Usp
k59_1347574_1	187272.Mlg_2438	8.92e-70	219.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1WWA7@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_935802_1	395493.BegalDRAFT_0809	2.22e-59	204.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,45ZS9@72273|Thiotrichales	72273|Thiotrichales	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_1102614_1	765914.ThisiDRAFT_0926	1.14e-46	156.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1WX5A@135613|Chromatiales	135613|Chromatiales	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_330260_1	1304865.JAGF01000001_gene2477	1.02e-76	259.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,COG1145@2|Bacteria,2I995@201174|Actinobacteria	201174|Actinobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1102617_1	1121943.KB899999_gene1339	2.39e-08	63.2	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,1XN8A@135619|Oceanospirillales	135619|Oceanospirillales	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
k59_1738534_1	640081.Dsui_3214	3.17e-80	280.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VI92@28216|Betaproteobacteria,2KUW5@206389|Rhodocyclales	206389|Rhodocyclales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1738534_3	215358.XP_010735763.1	0.000203	43.9	KOG0118@1|root,KOG0118@2759|Eukaryota,38H08@33154|Opisthokonta,3BAHX@33208|Metazoa,3D02D@33213|Bilateria,48997@7711|Chordata,48XB7@7742|Vertebrata,4A5QF@7898|Actinopterygii	33208|Metazoa	A	Heterogeneous nuclear ribonucleoprotein A	HNRNPAB	GO:0000122,GO:0001837,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006355,GO:0006357,GO:0007275,GO:0008150,GO:0009888,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0030154,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0044798,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048731,GO:0048762,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0060485,GO:0065007,GO:0070013,GO:0080090,GO:0090575,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990904,GO:2000112,GO:2000113,GO:2001141	-	ko:K03102,ko:K13044	ko04320,map04320	-	-	-	ko00000,ko00001,ko03019,ko03041	-	-	-	CBFNT,RRM_1
k59_1347610_1	1129794.C427_0387	4.14e-08	53.9	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,465JS@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	HflC and HflK could regulate a protease	hflC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_1347610_2	314278.NB231_15488	2.59e-11	59.7	COG3242@1|root,COG3242@2|Bacteria,1PU4H@1224|Proteobacteria,1RWCT@1236|Gammaproteobacteria,1WZPF@135613|Chromatiales	135613|Chromatiales	S	protein conserved in bacteria	-	-	-	ko:K09937	-	-	-	-	ko00000	-	-	-	DUF2065
k59_1347610_3	1123228.AUIH01000002_gene1603	2.58e-23	97.4	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1XHUK@135619|Oceanospirillales	135619|Oceanospirillales	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
k59_682786_1	1124983.PFLCHA0_c20270	4.99e-42	152.0	COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2208@2|Bacteria,1R3UE@1224|Proteobacteria,1RRJX@1236|Gammaproteobacteria,1YPWW@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	KT	Sigma factor PP2C-like phosphatases	rssB	GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0009893,GO:0010556,GO:0010604,GO:0016989,GO:0019219,GO:0019222,GO:0030162,GO:0031323,GO:0031325,GO:0031326,GO:0031647,GO:0031648,GO:0032268,GO:0032270,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0140110,GO:1903506,GO:2001141	3.1.3.3	ko:K02485,ko:K07315	-	-	-	-	ko00000,ko01000,ko02022,ko03021	-	-	-	Response_reg,SpoIIE
k59_1102640_1	1463821.JOGR01000004_gene2359	5.23e-34	131.0	COG4447@1|root,COG4447@2|Bacteria,2GM8J@201174|Actinobacteria,4EY17@85014|Glycomycetales	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR_6
k59_1277219_1	598467.BrE312_3248	4.88e-14	78.6	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,1T26Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Member of the two-component regulatory system AtoS AtoC. In the presence of acetoacetate, AtoS AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoS is a membrane-associated kinase that phosphorylates and activates AtoC in response to environmental signals	atoS	GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K07710	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS
k59_1386254_1	110319.CF8_4253	6.55e-128	379.0	COG4584@1|root,COG4584@2|Bacteria,2GM4J@201174|Actinobacteria,4DTTK@85009|Propionibacteriales	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_682793_1	593907.Celgi_2106	9.84e-51	172.0	COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria,4F15R@85016|Cellulomonadaceae	201174|Actinobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
k59_1347623_1	1168065.DOK_05245	6.46e-50	172.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,1J946@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_55878_1	1713.JOFV01000010_gene1215	1.21e-90	273.0	COG0092@1|root,COG0092@2|Bacteria,2GKF1@201174|Actinobacteria,4F0DZ@85016|Cellulomonadaceae	201174|Actinobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_288704_1	1463821.JOGR01000020_gene1176	1.94e-25	103.0	COG2860@1|root,COG2860@2|Bacteria,2GMI4@201174|Actinobacteria,4EYNG@85014|Glycomycetales	201174|Actinobacteria	S	UPF0126 domain	-	-	-	-	-	-	-	-	-	-	-	-	UPF0126
k59_1445989_2	573413.Spirs_1825	7.77e-33	124.0	COG2197@1|root,COG2197@2|Bacteria,2J6J1@203691|Spirochaetes	203691|Spirochaetes	K	regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_793508_1	396588.Tgr7_0886	5.35e-37	137.0	COG3380@1|root,COG3380@2|Bacteria,1R5C0@1224|Proteobacteria,1S3X1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers	-	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050664,GO:0051287,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363	-	ko:K06955	-	-	-	-	ko00000	-	-	-	Amino_oxidase,NAD_binding_8
k59_505928_1	1278309.KB907100_gene2320	1.48e-79	247.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1XH97@135619|Oceanospirillales	135619|Oceanospirillales	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1738561_1	714083.JH370377_gene1918	6.34e-10	58.9	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4FNZ3@85023|Microbacteriaceae	201174|Actinobacteria	L	Conserved hypothetical protein 95	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
k59_1738561_2	1146883.BLASA_3812	3.62e-47	155.0	COG0669@1|root,COG0669@2|Bacteria,2GN1S@201174|Actinobacteria,4ESMC@85013|Frankiales	201174|Actinobacteria	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_1794800_1	1128912.GMES_0380	7.21e-46	165.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1T3CM@1236|Gammaproteobacteria,46DAI@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	VRR_NUC	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,VRR_NUC
k59_1568498_1	156889.Mmc1_3409	5.35e-53	189.0	COG0642@1|root,COG0784@1|root,COG0834@1|root,COG2198@1|root,COG2202@1|root,COG0642@2|Bacteria,COG0784@2|Bacteria,COG0834@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,1NC9X@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07678	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3,dCache_1
k59_1626672_1	745014.OMB55_00017510	0.000127	47.4	COG1028@1|root,COG1028@2|Bacteria,1MXVZ@1224|Proteobacteria,1S8QD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_570949_2	1267005.KB911256_gene1872	5.63e-50	169.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,3N66U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	mtkA	-	6.2.1.5,6.2.1.9	ko:K01903,ko:K14067	ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00346,M00374,M00620	R00405,R01256,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_1519090_1	344747.PM8797T_24521	4.94e-30	125.0	2ECB1@1|root,3369C@2|Bacteria,2J4U8@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_570951_1	880072.Desac_0306	3.64e-116	339.0	COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,42MVZ@68525|delta/epsilon subdivisions,2WJ3N@28221|Deltaproteobacteria,2MQTU@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1986	Pan_kinase
k59_570951_2	397288.C806_01869	5.16e-15	75.9	COG1109@1|root,COG1109@2|Bacteria,1TP1X@1239|Firmicutes,2499P@186801|Clostridia,27IQD@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_453782_1	452637.Oter_4539	5.9e-64	206.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
k59_160926_1	768671.ThimaDRAFT_3266	2.11e-87	276.0	COG0664@1|root,COG2066@1|root,COG0664@2|Bacteria,COG2066@2|Bacteria,1MWB5@1224|Proteobacteria,1RMY9@1236|Gammaproteobacteria,1WYNM@135613|Chromatiales	135613|Chromatiales	E	Belongs to the glutaminase family	glsA	-	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Glutaminase
k59_1519127_2	1123504.JQKD01000011_gene2414	1.87e-08	55.8	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2VKXN@28216|Betaproteobacteria,4ABTB@80864|Comamonadaceae	28216|Betaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_1392645_1	1169152.AXVD01000009_gene96	1.42e-44	167.0	COG0068@1|root,COG0068@2|Bacteria,2GJYF@201174|Actinobacteria,4FVKA@85025|Nocardiaceae	201174|Actinobacteria	O	HypF finger	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_1392645_2	2340.JV46_24290	1.96e-122	358.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1J9VF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Hydrogenase formation hypA family	hypD	GO:0003674,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0036211,GO:0042165,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070025,GO:0071704,GO:1901564	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
k59_337219_1	69395.JQLZ01000003_gene325	4.09e-16	75.1	COG0625@1|root,COG0625@2|Bacteria,1MXHH@1224|Proteobacteria,2TVGY@28211|Alphaproteobacteria,2KFYF@204458|Caulobacterales	204458|Caulobacterales	O	Belongs to the GST superfamily	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N
k59_337219_2	493475.GARC_3279	4.17e-06	50.4	COG3239@1|root,COG3239@2|Bacteria,1MXTQ@1224|Proteobacteria,1RRM8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
k59_1036887_1	349521.HCH_00744	5.06e-87	267.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1XH97@135619|Oceanospirillales	135619|Oceanospirillales	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1568538_1	492774.JQMB01000001_gene6237	1.21e-99	298.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2TS09@28211|Alphaproteobacteria,4B9UD@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_747962_2	686340.Metal_2550	2.1e-25	104.0	COG0224@1|root,COG0224@2|Bacteria,1RIE5@1224|Proteobacteria,1S3ZW@1236|Gammaproteobacteria,1XF9U@135618|Methylococcales	135618|Methylococcales	C	ATP synthase	-	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_1285156_1	1267535.KB906767_gene2254	3.54e-36	132.0	COG2945@1|root,COG2945@2|Bacteria,3Y35I@57723|Acidobacteria,2JIVZ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4
k59_337236_1	1517416.IDAT_11080	4.2e-51	171.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,2QFMS@267893|Idiomarinaceae	1236|Gammaproteobacteria	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
k59_453813_1	690850.Desaf_1234	9.06e-109	331.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2M915@213115|Desulfovibrionales	28221|Deltaproteobacteria	NU	PFAM Type II secretion system protein E	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_1036905_1	1049564.TevJSym_bc00390	7.35e-86	269.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,1JARP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Nickel-dependent hydrogenase	hydB	-	1.12.5.1,1.12.99.6	ko:K05922,ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_1036905_3	2340.JV46_26700	2.81e-104	313.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1JBG6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cysteine-rich domain	dgcB	-	-	ko:K21834	-	-	-	-	ko00000	-	-	-	CCG,DUF3483,Fer4_8
k59_219213_1	1380354.JIAN01000006_gene593	7.31e-07	50.8	COG1716@1|root,COG1716@2|Bacteria,2GK5I@201174|Actinobacteria,4F1PK@85016|Cellulomonadaceae	201174|Actinobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
k59_219213_2	1032480.MLP_32200	5.23e-61	200.0	COG2304@1|root,COG2304@2|Bacteria,2GMWM@201174|Actinobacteria,4DNF0@85009|Propionibacteriales	201174|Actinobacteria	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2,VWA_3
k59_1568571_1	1266908.AQPB01000049_gene798	1.39e-05	46.2	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WW5M@135613|Chromatiales	135613|Chromatiales	EH	Anthranilate synthase component I	-	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_1568571_2	472759.Nhal_3120	3.86e-40	142.0	COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,1WXUQ@135613|Chromatiales	135613|Chromatiales	EH	PFAM Aminotransferase, class IV	-	-	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	-	Aminotran_4
k59_747976_1	1035191.HMPREF0185_03461	2.24e-92	308.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2KFWJ@204458|Caulobacterales	204458|Caulobacterales	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_571000_1	439235.Dalk_0310	2.87e-23	102.0	COG2304@1|root,COG2885@1|root,COG2304@2|Bacteria,COG2885@2|Bacteria,1R8DG@1224|Proteobacteria,42NGC@68525|delta/epsilon subdivisions,2WMAP@28221|Deltaproteobacteria,2MPGP@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM von Willebrand factor type A domain	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA,Phenol_MetA_deg,TSP_3,VWA
k59_337249_1	395495.Lcho_3739	3.15e-13	79.7	COG0689@1|root,COG5276@1|root,COG0689@2|Bacteria,COG5276@2|Bacteria,1QVI5@1224|Proteobacteria	1224|Proteobacteria	N	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,He_PIG,LVIVD
k59_1392691_1	864051.BurJ1DRAFT_3327	3.28e-30	118.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria,1KKEG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	NADPH-dependent glutamate synthase beta	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_21,Fer4_7,Pyr_redox_2,Pyr_redox_3
k59_1392691_2	2340.JV46_15450	1.02e-55	188.0	COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S dicluster domain	dsrK	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8
k59_1392692_1	631362.Thi970DRAFT_02304	5.29e-30	112.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,1WW24@135613|Chromatiales	135613|Chromatiales	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
k59_1392692_2	59538.XP_005976884.1	1.37e-27	110.0	COG0466@1|root,KOG2004@2759|Eukaryota,38E0Y@33154|Opisthokonta,3BCE6@33208|Metazoa,3CT0G@33213|Bilateria,484SC@7711|Chordata,492UD@7742|Vertebrata,3J8KK@40674|Mammalia,4J7VF@91561|Cetartiodactyla	33208|Metazoa	O	Lon protease homolog 2	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0006508,GO:0006605,GO:0006625,GO:0006807,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015031,GO:0015833,GO:0016043,GO:0016485,GO:0019538,GO:0031907,GO:0031974,GO:0033036,GO:0033365,GO:0034613,GO:0042579,GO:0042886,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043574,GO:0044238,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051604,GO:0051641,GO:0051649,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072594,GO:0072662,GO:0072663,GO:1901564	3.4.21.53	ko:K01338,ko:K08675	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03029	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_747989_1	1380356.JNIK01000002_gene4843	1.2e-34	134.0	COG0582@1|root,COG0582@2|Bacteria,2GTYQ@201174|Actinobacteria,4EW1T@85013|Frankiales	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
k59_1568593_1	104623.Ser39006_01039	5.8e-21	99.0	COG0508@1|root,COG2267@1|root,COG0508@2|Bacteria,COG2267@2|Bacteria,1MVAI@1224|Proteobacteria,1RY6P@1236|Gammaproteobacteria,402FZ@613|Serratia	1236|Gammaproteobacteria	I	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation	rutD	-	2.3.1.12	ko:K00627,ko:K09023	ko00010,ko00020,ko00240,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00240,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569,R09983	RC00004,RC02742,RC02769,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4
k59_629960_1	1266914.ATUK01000018_gene686	1.05e-45	163.0	COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,1RNUM@1236|Gammaproteobacteria,1WW3E@135613|Chromatiales	135613|Chromatiales	S	Deoxyribodipyrimidine photo-lyase-related protein	-	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP
k59_629960_2	396588.Tgr7_2118	9.07e-85	258.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1WWI6@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_1110476_1	1121937.AUHJ01000001_gene467	7.94e-24	104.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,46526@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Phosphate transport system permease	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_512584_2	1121405.dsmv_3691	1.91e-45	157.0	COG3547@1|root,COG3547@2|Bacteria,1NP2U@1224|Proteobacteria,43A5Q@68525|delta/epsilon subdivisions,2X2AM@28221|Deltaproteobacteria,2MPDW@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1285244_1	697282.Mettu_1558	2.73e-46	157.0	COG0428@1|root,COG0428@2|Bacteria,1R40E@1224|Proteobacteria,1RRYS@1236|Gammaproteobacteria,1XDSY@135618|Methylococcales	135618|Methylococcales	P	ZIP Zinc transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_689196_1	1121272.KB903283_gene5183	1.93e-89	287.0	COG1649@1|root,COG1649@2|Bacteria,2GKNP@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyl hydrolase-like 10	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,GHL10
k59_571037_1	1298864.AUEQ01000013_gene811	5.21e-55	190.0	COG1020@1|root,COG1020@2|Bacteria,2GKU0@201174|Actinobacteria,234ZI@1762|Mycobacteriaceae	201174|Actinobacteria	I	Belongs to the long-chain O-acyltransferase family	-	GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
k59_571037_2	1078020.KEK_17598	2.99e-10	60.5	COG0204@1|root,COG0560@1|root,COG0204@2|Bacteria,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,233PB@1762|Mycobacteriaceae	201174|Actinobacteria	EI	HAD-superfamily subfamily IB hydrolase, TIGR01490	plsC	-	2.3.1.51,3.1.3.3	ko:K00655,ko:K15781	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase,HAD
k59_1800471_1	292415.Tbd_0245	1.31e-118	345.0	COG1132@1|root,COG1132@2|Bacteria,1MX5V@1224|Proteobacteria	1224|Proteobacteria	V	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1036967_1	864069.MicloDRAFT_00070330	6.2e-68	218.0	COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,2UCIY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	High confidence in function and specificity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
k59_798605_1	234621.RER_01620	3.79e-31	122.0	COG0628@1|root,COG0628@2|Bacteria,2GM01@201174|Actinobacteria,4FXD0@85025|Nocardiaceae	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1285284_1	223283.PSPTO_1646	0.000193	44.7	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1Z4XZ@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	NU	COG3170 Tfp pilus assembly protein FimV	fimV	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	LysM
k59_1285284_2	1234364.AMSF01000005_gene774	4.45e-44	152.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,1X2X5@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_161038_2	156889.Mmc1_2110	1.86e-39	143.0	COG1453@1|root,COG1453@2|Bacteria,1RAU3@1224|Proteobacteria	1224|Proteobacteria	S	PFAM aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red
k59_1519284_2	1297863.APJF01000013_gene3970	2.72e-63	203.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MURA@1224|Proteobacteria,2TR1F@28211|Alphaproteobacteria,3JUUY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Rhodanese Homology Domain	MA20_22850	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
k59_1217633_1	570967.JMLV01000002_gene1767	1.59e-86	264.0	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,2TS96@28211|Alphaproteobacteria,2JP84@204441|Rhodospirillales	204441|Rhodospirillales	E	periplasmic protein kinase ArgK and related GTPases of G3E family	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
k59_1519287_1	7668.SPU_016539-tr	1.31e-28	120.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3BPSU@33208|Metazoa,3E41R@33213|Bilateria	33208|Metazoa	IQ	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_748047_1	1051632.TPY_0497	9.84e-11	63.9	COG1484@1|root,COG1484@2|Bacteria,1TPPI@1239|Firmicutes,24DKZ@186801|Clostridia	186801|Clostridia	L	IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_571062_1	1163407.UU7_07451	8.49e-08	58.5	COG3725@1|root,COG3725@2|Bacteria,1MYFA@1224|Proteobacteria,1SE2J@1236|Gammaproteobacteria,1X4YH@135614|Xanthomonadales	135614|Xanthomonadales	V	Membrane protein required for beta-lactamase induction	ampE	-	-	ko:K03807	-	-	-	-	ko00000	-	-	-	CobD_Cbib
k59_1110548_1	1121434.AULY01000009_gene1972	9.74e-24	103.0	COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,1RCHY@1224|Proteobacteria,42R1G@68525|delta/epsilon subdivisions,2WMR7@28221|Deltaproteobacteria,2M83U@213115|Desulfovibrionales	28221|Deltaproteobacteria	KT	SMART protein phosphatase 2C domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE
k59_1153552_1	1049564.TevJSym_ac00090	4.75e-172	492.0	COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,1RQ8F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Nitrous oxidase accessory protein	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
k59_865038_1	768671.ThimaDRAFT_3069	4.71e-72	236.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1WXQN@135613|Chromatiales	135613|Chromatiales	EQ	PFAM Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k59_689251_1	572477.Alvin_2887	6.42e-35	131.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1WXE8@135613|Chromatiales	135613|Chromatiales	S	PFAM Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_798644_1	1042377.AFPJ01000010_gene1436	1.46e-38	137.0	COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,1RRXT@1236|Gammaproteobacteria,464II@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Deoxynucleoside kinase	dgk	-	-	-	-	-	-	-	-	-	-	-	dNK
k59_1745646_1	1121937.AUHJ01000004_gene970	6.44e-108	326.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,1T20X@1236|Gammaproteobacteria,464H1@72275|Alteromonadaceae	1236|Gammaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
k59_337367_2	305700.B447_02536	5.82e-50	167.0	COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,2VJX0@28216|Betaproteobacteria,2KXZK@206389|Rhodocyclales	206389|Rhodocyclales	S	Uncharacterised protein family (UPF0014)	-	-	-	ko:K02069	-	M00211	-	-	ko00000,ko00002,ko02000	9.B.25.1	-	-	UPF0014
k59_1217682_1	2340.JV46_24270	1.09e-147	424.0	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,1RQBE@1236|Gammaproteobacteria,1JA5R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	AIR synthase related protein, N-terminal domain	hypE	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0018193,GO:0018198,GO:0018249,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046892,GO:0051604,GO:0071704,GO:1901564	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
k59_1217682_2	765914.ThisiDRAFT_1813	2.49e-24	94.7	COG2608@1|root,COG2608@2|Bacteria,1N81B@1224|Proteobacteria,1SD0H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Heavy-metal-associated domain	-	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
k59_799612_1	1121937.AUHJ01000011_gene2880	6.95e-111	339.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,1RMA1@1236|Gammaproteobacteria,465WW@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	COG4166 ABC-type oligopeptide transport system, periplasmic component	-	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
k59_866639_1	82654.Pse7367_1858	5.2e-19	91.3	COG2931@1|root,COG2931@2|Bacteria,1G3DW@1117|Cyanobacteria,1HAZM@1150|Oscillatoriales	1117|Cyanobacteria	Q	Domain of unknown function (DUF4347)	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4114,DUF4347,HemolysinCabind
k59_1801686_1	1348114.OM33_21000	1.22e-56	187.0	COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,1RNAA@1236|Gammaproteobacteria,2Q3UZ@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	IQ	Fungal family of unknown function (DUF1776)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_749448_1	765913.ThidrDRAFT_2014	1.48e-156	467.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMA7@1236|Gammaproteobacteria,1WWVT@135613|Chromatiales	135613|Chromatiales	E	PFAM peptidase M1, membrane alanine aminopeptidase	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
k59_1038510_1	765911.Thivi_3452	3.03e-43	154.0	COG3842@1|root,COG3842@2|Bacteria,1RC3N@1224|Proteobacteria,1RXZ2@1236|Gammaproteobacteria,1WWI4@135613|Chromatiales	135613|Chromatiales	E	PFAM ABC transporter	-	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE_2
k59_338695_1	1125973.JNLC01000013_gene3797	1.41e-75	248.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria,3JQMS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	UvrD-like helicase C-terminal domain	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1628251_1	497964.CfE428DRAFT_4695	2.97e-100	326.0	COG1196@1|root,COG1196@2|Bacteria,46TT8@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_749460_1	1095767.CAHD01000234_gene2786	1.36e-41	145.0	COG0671@1|root,COG0671@2|Bacteria,2HXWM@201174|Actinobacteria,4F1CW@85016|Cellulomonadaceae	201174|Actinobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
k59_749460_2	1894.JOER01000038_gene3039	1.74e-15	74.7	COG2110@1|root,COG2110@2|Bacteria,2IFEC@201174|Actinobacteria	201174|Actinobacteria	S	domain protein	lppD	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Macro
k59_459538_1	1120958.AULD01000005_gene1950	4.7e-85	266.0	COG1322@1|root,COG1322@2|Bacteria,2GP4U@201174|Actinobacteria,4FMID@85023|Microbacteriaceae	201174|Actinobacteria	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
k59_1806121_1	1121405.dsmv_3251	4.41e-61	207.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2MHZG@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
k59_1045558_1	1223410.KN050846_gene2603	2.38e-10	60.8	COG3844@1|root,COG3844@2|Bacteria,4NECS@976|Bacteroidetes,1HWY8@117743|Flavobacteriia	976|Bacteroidetes	E	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
k59_1045558_2	1210884.HG799470_gene14485	1.28e-68	220.0	COG1878@1|root,COG1878@2|Bacteria	2|Bacteria	S	arylformamidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
k59_226270_2	1298593.TOL_3046	2.74e-22	100.0	2C2C7@1|root,2Z85G@2|Bacteria,1PD07@1224|Proteobacteria,1RP6G@1236|Gammaproteobacteria,1XIKZ@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_803924_1	857087.Metme_3699	1.86e-24	93.6	COG1551@1|root,COG1551@2|Bacteria,1N6PG@1224|Proteobacteria,1SCB4@1236|Gammaproteobacteria,1XFPU@135618|Methylococcales	135618|Methylococcales	J	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding	csrA	-	-	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03019	-	-	-	CsrA
k59_803924_2	930169.B5T_03096	3.1e-109	328.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1XHQ7@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the aspartokinase family	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
k59_1634389_1	1400524.KL370779_gene1148	2.84e-20	92.8	COG0697@1|root,COG0697@2|Bacteria,1RAJV@1224|Proteobacteria,2U919@28211|Alphaproteobacteria,4BQBR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
k59_1399677_1	713586.KB900536_gene2638	1.58e-62	214.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1WWF6@135613|Chromatiales	135613|Chromatiales	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
k59_1045569_1	1121405.dsmv_1868	3.23e-23	94.7	2E8Z0@1|root,3338K@2|Bacteria,1NA5U@1224|Proteobacteria,42VST@68525|delta/epsilon subdivisions,2WRG6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3783)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3783
k59_168260_1	1101190.ARWB01000001_gene3642	8.76e-27	106.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2TSFJ@28211|Alphaproteobacteria,36X96@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Dihydrodipicolinate reductase, C-terminus	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
k59_168260_2	95619.PM1_0203425	2.22e-34	127.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the CarA family	carA	GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1950,iUTI89_1310.UTI89_C0036,ic_1306.c0040	CPSase_sm_chain,GATase
k59_1045577_1	1510531.JQJJ01000009_gene481	1.37e-70	221.0	COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2U06A@28211|Alphaproteobacteria,3JSMM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	transcriptional regulator, LuxR family	MA20_19670	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1751596_1	1198452.Jab_1c02450	3.52e-07	52.0	COG0300@1|root,COG0300@2|Bacteria,1R735@1224|Proteobacteria,2VH63@28216|Betaproteobacteria,476C9@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1751596_2	1123518.ARWI01000001_gene522	1.89e-102	314.0	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,1RP4P@1236|Gammaproteobacteria,45ZNJ@72273|Thiotrichales	72273|Thiotrichales	S	Flavin containing amine oxidoreductase	-	-	-	ko:K06954	-	-	-	-	ko00000	-	-	-	Amino_oxidase,NAD_binding_8
k59_1159374_1	998674.ATTE01000001_gene4298	1.29e-23	94.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,1RNEV@1236|Gammaproteobacteria,460ID@72273|Thiotrichales	72273|Thiotrichales	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_1159374_2	715451.ambt_19090	1.45e-45	150.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,1S5V2@1236|Gammaproteobacteria,4679B@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
k59_755271_1	1158756.AQXQ01000009_gene1193	9.33e-251	702.0	COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,1RP3E@1236|Gammaproteobacteria,1WWC6@135613|Chromatiales	135613|Chromatiales	M	Belongs to the BCCT transporter (TC 2.A.15) family	-	-	-	ko:K03451	-	-	-	-	ko00000	2.A.15	-	-	BCCT
k59_459579_1	1249627.D779_2341	6.82e-131	388.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1WVW6@135613|Chromatiales	135613|Chromatiales	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_1806162_1	1562701.BBOF01000022_gene709	5.13e-76	233.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ3Z@28216|Betaproteobacteria,1K11Z@119060|Burkholderiaceae	28216|Betaproteobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
k59_1806162_2	218493.SBG_0456	1.33e-58	190.0	COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,3ZKUT@590|Salmonella	1236|Gammaproteobacteria	S	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxH	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iE2348C_1286.E2348C_0457	Metallophos,Metallophos_2
k59_1634434_1	1121403.AUCV01000056_gene3012	5.99e-40	147.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MHU5@213118|Desulfobacterales	28221|Deltaproteobacteria	S	pfam abc-1	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
k59_1751613_1	367299.JOEE01000006_gene674	2.76e-55	183.0	2DJPX@1|root,32UDI@2|Bacteria,2IFS0@201174|Actinobacteria,4FHW4@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_343824_1	552811.Dehly_1699	1.38e-140	404.0	2CDJ3@1|root,2Z7R6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_755290_1	1127673.GLIP_3700	6.55e-12	66.2	COG0596@1|root,COG0596@2|Bacteria,1QUBR@1224|Proteobacteria,1RSF9@1236|Gammaproteobacteria,466FR@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters	bioH	GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016787,GO:0016788,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0052689,GO:0071704,GO:0072330,GO:0090499,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.1.85	ko:K02170	ko00780,ko01100,map00780,map01100	M00572	R09725	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	iBWG_1329.BWG_3103,iECBD_1354.ECBD_0333,iECDH10B_1368.ECDH10B_3587,iECDH1ME8569_1439.ECDH1ME8569_3291,iETEC_1333.ETEC_3662,iEcDH1_1363.EcDH1_0301,iJO1366.b3412,iY75_1357.Y75_RS20155	Abhydrolase_1,Abhydrolase_6
k59_755290_2	1000565.METUNv1_02919	1.04e-35	134.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,2VJP9@28216|Betaproteobacteria,2KUJH@206389|Rhodocyclales	206389|Rhodocyclales	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
k59_1576314_1	380394.Lferr_1363	1.24e-61	204.0	COG3395@1|root,COG3395@2|Bacteria,1QC4M@1224|Proteobacteria,1T7TD@1236|Gammaproteobacteria,2NBVC@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Putative nucleotide-binding of sugar-metabolising enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DUF1357_C,DUF1537
k59_1751620_1	1267005.KB911258_gene621	5.49e-54	189.0	COG0658@1|root,COG0658@2|Bacteria,1MUKF@1224|Proteobacteria,2TRD5@28211|Alphaproteobacteria,3N62J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4131)	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131
k59_1224920_1	1185652.USDA257_c33180	1.64e-18	85.9	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2TRBX@28211|Alphaproteobacteria,4B7KZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	ABC-type transport system, involved in lipoprotein release, permease component	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_1224920_2	1123261.AXDW01000001_gene1445	1.26e-42	147.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1X2X9@135614|Xanthomonadales	135614|Xanthomonadales	V	Part of the ABC transporter complex LolCDE involved in the translocation of	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
k59_755300_1	933262.AXAM01000046_gene142	3.01e-62	197.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,42MAM@68525|delta/epsilon subdivisions,2WK4Y@28221|Deltaproteobacteria,2MJCE@213118|Desulfobacterales	28221|Deltaproteobacteria	D	PFAM ABC transporter	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_755300_2	56780.SYN_01010	9.35e-34	131.0	COG1538@1|root,COG1538@2|Bacteria,1PTZ6@1224|Proteobacteria,42RK2@68525|delta/epsilon subdivisions,2WNMB@28221|Deltaproteobacteria,2MS0Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_872942_1	29581.BW37_04234	6.68e-60	202.0	COG4805@1|root,COG4805@2|Bacteria,1PIM6@1224|Proteobacteria,2WBEN@28216|Betaproteobacteria,475NK@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_1045653_1	754252.PFREUD_07070	4.7e-94	306.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1143@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1143@2|Bacteria,2I995@201174|Actinobacteria,4DVUV@85009|Propionibacteriales	201174|Actinobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_576886_1	1122915.AUGY01000020_gene6469	9.29e-57	190.0	COG4638@1|root,COG4638@2|Bacteria,1UZWG@1239|Firmicutes,4HBGQ@91061|Bacilli,26VC1@186822|Paenibacillaceae	2|Bacteria	P	Rieske [2Fe-2S] domain	ligX	-	-	ko:K15060	ko00627,ko01120,map00627,map01120	-	R09275	RC00392,RC01533	ko00000,ko00001	-	-	-	Rieske
k59_1399779_1	1158165.KB898871_gene2312	7.86e-17	78.2	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,1RNK9@1236|Gammaproteobacteria,1WYHT@135613|Chromatiales	135613|Chromatiales	CH	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
k59_1399779_2	711393.AYRX01000115_gene5615	1.18e-47	160.0	COG1941@1|root,COG1941@2|Bacteria,2GSPN@201174|Actinobacteria	201174|Actinobacteria	C	NADH ubiquinone oxidoreductase, 20	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
k59_1695220_1	580332.Slit_1715	9.34e-177	507.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2VHJ5@28216|Betaproteobacteria,44WIW@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Fumarate reductase flavoprotein C-term	-	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1224966_1	584708.Apau_1731	9.16e-09	57.0	COG1785@1|root,COG1785@2|Bacteria,3T9TD@508458|Synergistetes	508458|Synergistetes	P	Belongs to the alkaline phosphatase family	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
k59_1224966_2	452637.Oter_3535	4.29e-55	183.0	COG1192@1|root,COG1192@2|Bacteria,46SKQ@74201|Verrucomicrobia,3K7TC@414999|Opitutae	414999|Opitutae	D	ATPase MipZ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_695774_2	96561.Dole_1591	5.9e-28	108.0	2BHAV@1|root,32BCF@2|Bacteria,1NDPS@1224|Proteobacteria,42SQW@68525|delta/epsilon subdivisions,2WSCF@28221|Deltaproteobacteria,2MKA5@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1695233_1	446469.Sked_13030	1.73e-57	196.0	COG5337@1|root,COG5337@2|Bacteria,2GN9M@201174|Actinobacteria	201174|Actinobacteria	M	COG5337 Spore coat assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH
k59_695775_1	1249627.D779_1402	8.09e-82	269.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,1WW9S@135613|Chromatiales	135613|Chromatiales	E	Bacterial transglutaminase-like N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
k59_1224975_1	509190.Cseg_1483	1.2e-26	114.0	COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2KFWJ@204458|Caulobacterales	204458|Caulobacterales	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_872996_1	765913.ThidrDRAFT_1430	1.06e-33	120.0	28NV7@1|root,2ZBTD@2|Bacteria,1RAH4@1224|Proteobacteria,1S2YP@1236|Gammaproteobacteria,1WY67@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_872996_2	765913.ThidrDRAFT_1428	5.95e-28	107.0	COG0639@1|root,COG0639@2|Bacteria,1MXN9@1224|Proteobacteria,1RYPF@1236|Gammaproteobacteria,1WXJ5@135613|Chromatiales	135613|Chromatiales	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
k59_226388_1	2340.JV46_13140	3e-62	206.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,1T20X@1236|Gammaproteobacteria,1J4VN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
k59_1045704_1	1095767.CAHD01000210_gene2645	3.7e-79	254.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4F1W0@85016|Cellulomonadaceae	201174|Actinobacteria	L	PFAM DEAD DEAH box helicase domain protein	deaD	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K05592,ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
k59_1399806_1	1267535.KB906767_gene4070	9.89e-60	195.0	COG3570@1|root,COG3570@2|Bacteria	2|Bacteria	V	aminoglycoside hydroxyurea antibiotic resistance kinase	strB	-	2.7.1.72	ko:K04343	-	M00766	R02225	RC00002,RC00078	br01600,ko00000,ko00002,ko01000,ko01504	-	-	-	APH_6_hur
k59_1045705_1	1121405.dsmv_2552	1.17e-75	239.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria,2MHRE@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM glutamine synthetase, type I	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_1225008_1	713586.KB900536_gene582	2.31e-128	380.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,1RMB8@1236|Gammaproteobacteria,1WYRX@135613|Chromatiales	135613|Chromatiales	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
k59_1695277_1	1304865.JAGF01000001_gene1856	7.44e-76	246.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4F0X8@85016|Cellulomonadaceae	201174|Actinobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_804049_1	713587.THITH_07385	3.26e-40	148.0	COG0457@1|root,COG0457@2|Bacteria,1QXGV@1224|Proteobacteria	1224|Proteobacteria	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_1225014_1	765911.Thivi_3924	2.66e-115	345.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1WXM2@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_168411_1	1342302.JASC01000002_gene74	1.33e-71	229.0	COG0577@1|root,COG0577@2|Bacteria,1MVN1@1224|Proteobacteria,2TTEF@28211|Alphaproteobacteria	1224|Proteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	MacB_PCD
k59_755394_1	631454.N177_4163	3.15e-101	312.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,1JNHF@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_804060_1	269799.Gmet_1848	7.3e-80	252.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,42MSB@68525|delta/epsilon subdivisions,2WJI6@28221|Deltaproteobacteria,43TW2@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_1159491_1	1168065.DOK_02901	7.93e-33	120.0	COG1573@1|root,COG1573@2|Bacteria,1R9XV@1224|Proteobacteria,1S20R@1236|Gammaproteobacteria,1J636@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Uracil-DNA glycosylase	-	-	-	-	-	-	-	-	-	-	-	-	UDG
k59_1159491_2	159087.Daro_1778	3.43e-86	263.0	COG2009@1|root,2ZBTX@2|Bacteria,1RB22@1224|Proteobacteria,2VURZ@28216|Betaproteobacteria,2KYHM@206389|Rhodocyclales	206389|Rhodocyclales	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_757091_1	1051632.TPY_0667	1.77e-28	107.0	COG0393@1|root,COG0393@2|Bacteria,1VADM@1239|Firmicutes,24J8R@186801|Clostridia,3WDP0@538999|Clostridiales incertae sedis	186801|Clostridia	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
k59_1226840_1	572477.Alvin_2822	2.6e-22	93.6	COG1360@1|root,COG1360@2|Bacteria,1QUFR@1224|Proteobacteria,1T1XE@1236|Gammaproteobacteria,1WX8G@135613|Chromatiales	135613|Chromatiales	N	PFAM OmpA MotB domain protein	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
k59_1226840_2	765910.MARPU_15290	3.26e-108	320.0	COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,1RNRP@1236|Gammaproteobacteria,1WX44@135613|Chromatiales	135613|Chromatiales	N	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
k59_1226840_3	1280001.BAOA01000064_gene2638	4.29e-18	83.2	COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,1RNAA@1236|Gammaproteobacteria,1XTR2@135623|Vibrionales	135623|Vibrionales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	ybbO	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_805462_1	639283.Snov_2529	2.42e-79	262.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria,3EY0Y@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	FAD linked oxidases, C-terminal domain	MA20_43170	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_1807714_1	765911.Thivi_2455	3.98e-64	216.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,1WXVP@135613|Chromatiales	135613|Chromatiales	P	PFAM von Willebrand factor type A	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_2
k59_1578344_1	1121481.AUAS01000015_gene2187	2.76e-19	93.6	COG1538@1|root,COG1538@2|Bacteria,4NE4S@976|Bacteroidetes,47KIE@768503|Cytophagia	976|Bacteroidetes	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_637375_1	1297570.MESS4_270021	3.32e-15	75.1	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,43HJY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Belongs to the thiolase family	phbA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_637375_2	383381.EH30_06050	2.65e-08	53.5	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2TQWQ@28211|Alphaproteobacteria,2K0W5@204457|Sphingomonadales	204457|Sphingomonadales	S	synthesis repressor PhaR	phaR	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
k59_697368_1	272560.BPSL2271	6.54e-40	139.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,2VIQF@28216|Betaproteobacteria,1JZYF@119060|Burkholderiaceae	28216|Betaproteobacteria	M	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
k59_697368_2	1008459.TASI_1052	2.04e-18	84.3	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,3T25I@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_1160976_1	94122.Shewana3_2015	3.69e-17	85.9	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,2Q9JK@267890|Shewanellaceae	1236|Gammaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	2.7.13.3	ko:K10715,ko:K20974	ko02020,ko02024,ko02025,map02020,map02024,map02025	M00517,M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3365,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg
k59_518706_1	717785.HYPMC_0354	4e-110	333.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2TR3H@28211|Alphaproteobacteria,3N69J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_805472_1	1304865.JAGF01000001_gene1531	7.7e-51	172.0	COG1477@1|root,COG1477@2|Bacteria	2|Bacteria	H	protein flavinylation	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_578400_1	583355.Caka_2045	2.19e-09	63.9	COG0771@1|root,COG2911@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	murD	-	3.4.21.10,6.3.2.13,6.3.2.9	ko:K01317,ko:K01925,ko:K01928,ko:K01932	ko00300,ko00471,ko00550,ko01100,map00300,map00471,map00550,map01100	-	R02783,R02788	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01002,ko01011,ko04131	-	-	-	DUF1727,Mur_ligase_C,Mur_ligase_M
k59_1578358_1	402881.Plav_2467	3.6e-05	46.6	COG4126@1|root,COG4126@2|Bacteria,1RIP0@1224|Proteobacteria	1224|Proteobacteria	E	flavin adenine dinucleotide binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1578358_2	89187.ISM_10496	6.29e-66	211.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2TVNW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
k59_461188_1	693661.Arcve_1733	9.07e-41	146.0	COG0842@1|root,arCOG01467@2157|Archaea,2XU41@28890|Euryarchaeota	28890|Euryarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_578404_1	717785.HYPMC_3322	4.19e-105	310.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	2.7.7.49	ko:K00986,ko:K07497	-	-	-	-	ko00000,ko01000	-	-	-	HTH_32,rve
k59_875079_1	765912.Thimo_0152	1.24e-40	140.0	2E6CU@1|root,3310G@2|Bacteria,1NBK1@1224|Proteobacteria,1S5EP@1236|Gammaproteobacteria,1WYBI@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_345515_1	1121935.AQXX01000109_gene480	1.34e-112	354.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1XHSN@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_1578362_2	446466.Cfla_2346	1.07e-14	75.5	COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria,4F0RD@85016|Cellulomonadaceae	201174|Actinobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_1226873_1	926560.KE387023_gene2235	4.97e-53	177.0	COG0454@1|root,COG0456@2|Bacteria,1WMPD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10,FR47
k59_170111_1	305900.GV64_03630	1.53e-56	188.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1XHSK@135619|Oceanospirillales	135619|Oceanospirillales	J	SAM-dependent	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
k59_1595755_1	1123065.ATWL01000009_gene1011	5.13e-78	243.0	COG0673@1|root,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria	201174|Actinobacteria	C	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_187977_1	1304865.JAGF01000001_gene992	1.28e-126	384.0	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4F134@85016|Cellulomonadaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 65, C-terminal domain	-	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
k59_368834_1	253839.SSNG_03735	2.05e-13	68.9	2ED08@1|root,33H8A@2|Bacteria,2GQB6@201174|Actinobacteria	201174|Actinobacteria	S	Truncated CDS	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_19746_1	710685.MycrhN_2823	9.03e-159	469.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,2344K@1762|Mycobacteriaceae	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K12954,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3,3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_1595767_2	1385515.N791_09370	6.86e-23	99.8	COG4258@1|root,COG4258@2|Bacteria,1MU1E@1224|Proteobacteria,1RMP8@1236|Gammaproteobacteria,1X5EV@135614|Xanthomonadales	135614|Xanthomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	MMPL
k59_368858_1	1042375.AFPL01000044_gene1240	2.07e-57	188.0	COG0438@1|root,COG0438@2|Bacteria,1QF9A@1224|Proteobacteria,1RMDT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	glycosyl transferase group 1	capM2_2	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_1595774_1	1480694.DC28_15440	1.89e-92	286.0	COG3328@1|root,COG3328@2|Bacteria,2J57X@203691|Spirochaetes	203691|Spirochaetes	L	PFAM Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_75359_1	748247.AZKH_0592	2.29e-71	221.0	COG0726@1|root,COG0726@2|Bacteria,1MWR2@1224|Proteobacteria,2VQAV@28216|Betaproteobacteria	28216|Betaproteobacteria	G	polysaccharide deacetylase	icaB	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
k59_75359_2	450851.PHZ_c0613	4.57e-06	49.7	COG0438@1|root,COG0438@2|Bacteria,1QF9A@1224|Proteobacteria,2TVC0@28211|Alphaproteobacteria,2KH90@204458|Caulobacterales	204458|Caulobacterales	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
k59_1071829_1	765913.ThidrDRAFT_3989	1.25e-33	123.0	COG1863@1|root,COG1863@2|Bacteria,1N7MB@1224|Proteobacteria,1SCQX@1236|Gammaproteobacteria,1WYUR@135613|Chromatiales	135613|Chromatiales	P	PFAM cation antiporter	-	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
k59_1713411_1	1121405.dsmv_3813	2.1e-101	306.0	COG2807@1|root,COG2807@2|Bacteria,1QW3Y@1224|Proteobacteria,42MUB@68525|delta/epsilon subdivisions,2WIX2@28221|Deltaproteobacteria,2MJ4V@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Major facilitator superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
k59_188010_1	393595.ABO_0740	1.96e-26	103.0	COG2050@1|root,COG2050@2|Bacteria,1MZRJ@1224|Proteobacteria,1SB8G@1236|Gammaproteobacteria,1XS8K@135619|Oceanospirillales	135619|Oceanospirillales	Q	protein, possibly involved in aromatic compounds catabolism	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_956125_1	754476.Q7A_2535	5.55e-76	235.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,460E7@72273|Thiotrichales	72273|Thiotrichales	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1421096_2	1123256.KB907931_gene2842	1.45e-69	217.0	COG1028@1|root,COG1028@2|Bacteria,1N8G3@1224|Proteobacteria,1RZ80@1236|Gammaproteobacteria,1X66T@135614|Xanthomonadales	135614|Xanthomonadales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1126147_2	631362.Thi970DRAFT_02962	1.15e-13	75.1	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria,1WXTF@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD dependent oxidoreductase	-	-	1.1.3.21,1.1.5.3	ko:K00105,ko:K00111	ko00564,ko01110,map00564,map01110	-	R00846,R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
k59_658720_1	1121937.AUHJ01000004_gene1080	1.73e-55	184.0	COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria,1S5IS@1236|Gammaproteobacteria,46B06@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_658720_2	1123401.JHYQ01000013_gene685	1.9e-08	57.4	COG4733@1|root,COG4733@2|Bacteria,1R55I@1224|Proteobacteria,1S5X2@1236|Gammaproteobacteria,462MH@72273|Thiotrichales	72273|Thiotrichales	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_773669_1	439235.Dalk_4420	3.4e-37	143.0	COG1835@1|root,COG1835@2|Bacteria,1R4CU@1224|Proteobacteria,42USJ@68525|delta/epsilon subdivisions,2WQ3J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_957577_1	96561.Dole_0427	5.51e-103	313.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIB8@213118|Desulfobacterales	28221|Deltaproteobacteria	T	response regulator receiver	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_305874_1	1205680.CAKO01000037_gene1260	1.62e-14	78.6	COG3221@1|root,COG3221@2|Bacteria,1MWFF@1224|Proteobacteria,2TUB4@28211|Alphaproteobacteria,2JQT4@204441|Rhodospirillales	204441|Rhodospirillales	P	ABC-type phosphate phosphonate transport system periplasmic component	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
k59_1248781_1	479433.Caci_5483	2.6e-86	261.0	COG0290@1|root,COG0290@2|Bacteria,2GJGT@201174|Actinobacteria	201174|Actinobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
k59_1248781_2	1504319.GM45_1445	5.3e-19	79.3	COG0291@1|root,COG0291@2|Bacteria,2GQZW@201174|Actinobacteria,3UWZP@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
k59_717341_1	1158150.KB906249_gene2422	6.29e-30	111.0	COG1051@1|root,COG1051@2|Bacteria,1RC3I@1224|Proteobacteria,1S34Y@1236|Gammaproteobacteria,1WY35@135613|Chromatiales	135613|Chromatiales	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_717341_2	314278.NB231_15233	4.48e-58	185.0	COG4577@1|root,COG4577@2|Bacteria,1QG1Y@1224|Proteobacteria,1RXZV@1236|Gammaproteobacteria,1WWCC@135613|Chromatiales	135613|Chromatiales	CQ	BMC	-	-	-	-	-	-	-	-	-	-	-	-	BMC
k59_76788_1	439481.Aboo_0375	2.22e-62	204.0	COG0649@1|root,arCOG01548@2157|Archaea,2XTWF@28890|Euryarchaeota,3F2KD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Belongs to the complex I 49 kDa subunit family	fpoD	-	1.1.98.4,1.5.98.3,1.6.5.3	ko:K00333,ko:K22161,ko:K22172,ko:K22173	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	iAF692.Mbar_A3409	Complex1_49kDa,NiFeSe_Hases
k59_834483_1	446466.Cfla_2125	4.67e-61	199.0	COG3239@1|root,COG3239@2|Bacteria,2GJKF@201174|Actinobacteria,4F10Y@85016|Cellulomonadaceae	201174|Actinobacteria	I	PFAM fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
k59_423339_1	880072.Desac_2578	2.78e-97	299.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2WJ5B@28221|Deltaproteobacteria,2MQTV@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C
k59_189066_1	1137799.GZ78_28330	1.88e-50	174.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,1XI99@135619|Oceanospirillales	135619|Oceanospirillales	L	glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
k59_957597_1	95619.PM1_0201865	1.04e-86	270.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	glnG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1837979_1	264198.Reut_A2099	1.52e-25	107.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2VJ1C@28216|Betaproteobacteria,1K27J@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_21288_1	1121918.ARWE01000001_gene2577	7.48e-07	50.8	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,42N90@68525|delta/epsilon subdivisions,2WJUU@28221|Deltaproteobacteria,43SE9@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_370344_1	1317124.DW2_18928	1.56e-16	77.8	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,2TVA2@28211|Alphaproteobacteria,2XP99@285107|Thioclava	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_370344_2	1317124.DW2_18923	8.4e-156	439.0	COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,2U0PH@28211|Alphaproteobacteria,2XP68@285107|Thioclava	28211|Alphaproteobacteria	L	IstB-like ATP binding N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,IstB_IS21_ATP
k59_540941_1	1303692.SFUL_5561	4.73e-34	137.0	COG3378@1|root,COG3378@2|Bacteria,2H1DT@201174|Actinobacteria	201174|Actinobacteria	T	Phage plasmid primase, P4 family	-	-	-	ko:K06919	-	-	-	-	ko00000	-	-	-	D5_N,DUF3854,Pox_D5,PriCT_1,Prim-Pol
k59_1483865_2	396588.Tgr7_2054	2.03e-67	205.0	COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,1S5XW@1236|Gammaproteobacteria,1X16T@135613|Chromatiales	135613|Chromatiales	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
k59_130442_1	635013.TherJR_1523	2.67e-48	168.0	COG1377@1|root,COG1377@2|Bacteria,1TPRP@1239|Firmicutes,248N7@186801|Clostridia,26168@186807|Peptococcaceae	186801|Clostridia	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401,ko:K13820	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1,Bac_export_2
k59_658757_1	933262.AXAM01000034_gene1559	4.03e-91	287.0	COG0664@1|root,COG0664@2|Bacteria,1R8R8@1224|Proteobacteria,42PH6@68525|delta/epsilon subdivisions,2WKQJ@28221|Deltaproteobacteria,2MJ5X@213118|Desulfobacterales	28221|Deltaproteobacteria	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_658757_2	335543.Sfum_2958	7.84e-164	469.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NMZ@68525|delta/epsilon subdivisions,2WIZ0@28221|Deltaproteobacteria,2MRBW@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
k59_189099_2	1278308.KB907077_gene1643	1.37e-37	136.0	COG2887@1|root,COG2887@2|Bacteria,2IBTP@201174|Actinobacteria,4FR5Q@85023|Microbacteriaceae	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
k59_957634_1	384765.SIAM614_19049	1.54e-106	324.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TR1I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase	ilvI	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_834508_1	519989.ECTPHS_05295	2.31e-166	471.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,1WWHP@135613|Chromatiales	135613|Chromatiales	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_834508_2	713587.THITH_04055	1.02e-28	107.0	COG2932@1|root,COG2932@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K09384	-	-	-	-	ko00000	-	-	-	DUF3427,HIT,HTH_31,Helicase_C,Methyltransf_25,PLDc_2,Peptidase_S24,ResIII
k59_834508_3	631362.Thi970DRAFT_04285	4.36e-65	202.0	COG0607@1|root,COG0607@2|Bacteria,1MZ87@1224|Proteobacteria,1S98V@1236|Gammaproteobacteria,1WY49@135613|Chromatiales	135613|Chromatiales	P	PFAM Rhodanese-like	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_834508_4	870187.Thini_4247	9.13e-99	293.0	COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,1RNXI@1236|Gammaproteobacteria,462II@72273|Thiotrichales	72273|Thiotrichales	T	helix_turn_helix, Lux Regulon	-	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_189106_1	1121396.KB893080_gene892	8.05e-54	178.0	COG1600@1|root,COG1600@2|Bacteria,1RAYI@1224|Proteobacteria,42R4W@68525|delta/epsilon subdivisions,2WK0B@28221|Deltaproteobacteria,2MJVT@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_21316_1	1545915.JROG01000008_gene3395	3.9e-46	162.0	COG1621@1|root,COG1621@2|Bacteria,1PIQ9@1224|Proteobacteria,2UCAU@28211|Alphaproteobacteria,2K0FA@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the glycosyl hydrolase 68 family	sacB	GO:0005575,GO:0005576	2.4.1.10,3.2.1.26	ko:K00692,ko:K01193	ko00052,ko00500,ko01100,ko02020,map00052,map00500,map01100,map02020	-	R00801,R00802,R02410,R03635,R03921,R05140,R06088	RC00028,RC00077	ko00000,ko00001,ko01000,ko01003	-	GH32,GH68	-	Glyco_hydro_68
k59_21316_2	1211815.CBYP010000073_gene3618	1.44e-60	194.0	COG0262@1|root,COG0262@2|Bacteria,2IN33@201174|Actinobacteria	201174|Actinobacteria	H	PFAM bifunctional deaminase-reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_1248851_1	243233.MCA1973	2.76e-23	96.3	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1S8RQ@1236|Gammaproteobacteria,1XFC3@135618|Methylococcales	135618|Methylococcales	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
k59_1248851_2	1049564.TevJSym_ah00220	8.17e-36	124.0	COG1993@1|root,COG1993@2|Bacteria,1N8TP@1224|Proteobacteria,1SDYH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
k59_254879_1	1047013.AQSP01000096_gene2178	8.29e-26	104.0	COG0413@1|root,COG0413@2|Bacteria,2NP1G@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_1126208_2	1121121.KB894289_gene2670	0.000113	44.7	COG0160@1|root,COG0160@2|Bacteria,1TRUG@1239|Firmicutes,4HBUU@91061|Bacilli,26QMY@186822|Paenibacillaceae	91061|Bacilli	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	ectB	-	2.6.1.76	ko:K00836	ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230	M00033	R06977	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_21319_1	1163617.SCD_n00379	1.25e-128	390.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	napA	-	-	ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_540966_2	870187.Thini_2730	6.38e-124	360.0	arCOG03638@1|root,2Z8W3@2|Bacteria,1N2PH@1224|Proteobacteria,1RMI8@1236|Gammaproteobacteria,461N8@72273|Thiotrichales	72273|Thiotrichales	S	Protein of unknown function (DUF1538)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1538
k59_540966_3	1280001.BAOA01000064_gene2634	5.77e-20	82.8	COG0347@1|root,COG0347@2|Bacteria,1RI28@1224|Proteobacteria,1S62Z@1236|Gammaproteobacteria,1XXA8@135623|Vibrionales	135623|Vibrionales	K	Belongs to the P(II) protein family	VV0993	-	-	-	-	-	-	-	-	-	-	-	-
k59_1838028_1	933262.AXAM01000056_gene3173	1e-67	216.0	COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,42MS1@68525|delta/epsilon subdivisions,2WJ97@28221|Deltaproteobacteria,2MJ1G@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_957646_1	1042156.CXIVA_22580	3.44e-42	150.0	COG0685@1|root,COG0685@2|Bacteria,1USZE@1239|Firmicutes,250HQ@186801|Clostridia	186801|Clostridia	C	Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
k59_773723_1	1335757.SPICUR_08315	9.63e-68	230.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_540968_1	1043493.BBLU01000002_gene1773	9.71e-38	147.0	COG1835@1|root,COG1835@2|Bacteria,2GKI5@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	yrhL	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_658788_1	1335757.SPICUR_07145	5.07e-65	212.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1WWQM@135613|Chromatiales	135613|Chromatiales	P	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_658788_2	765912.Thimo_0512	5.34e-47	160.0	COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1WX1P@135613|Chromatiales	135613|Chromatiales	S	Cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
k59_1073826_1	979556.MTES_1348	7.13e-38	141.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria,4FMBH@85023|Microbacteriaceae	201174|Actinobacteria	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_717419_2	398767.Glov_3107	7.25e-07	58.9	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,42R8A@68525|delta/epsilon subdivisions,2WM6Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM secretion protein HlyD family protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
k59_957659_2	1187851.A33M_3805	2.96e-32	124.0	COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,2TRD2@28211|Alphaproteobacteria,3FDJJ@34008|Rhodovulum	28211|Alphaproteobacteria	M	Transglycosylase SLT domain	MA20_01345	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,SLT_2
k59_540971_1	706587.Desti_3177	8.3e-79	255.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2MRHE@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_540971_2	868595.Desca_2053	1.38e-18	85.1	COG3383@1|root,COG3383@2|Bacteria,1UI1F@1239|Firmicutes,25EAG@186801|Clostridia,260KC@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM formate dehydrogenase, alpha subunit	-	-	1.17.1.10,1.17.1.9,1.6.5.3	ko:K00123,ko:K00336,ko:K05299	ko00190,ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00190,map00630,map00680,map00720,map01100,map01120,map01200	M00144,M00377	R00134,R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1714499_1	1116472.MGMO_77c00250	1.57e-21	97.4	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1XEF4@135618|Methylococcales	135618|Methylococcales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_370402_1	318586.Pden_1418	1.75e-16	79.3	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,2TRC9@28211|Alphaproteobacteria,2PUTC@265|Paracoccus	28211|Alphaproteobacteria	S	MazG nucleotide pyrophosphohydrolase domain	mazG	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
k59_370402_2	314230.DSM3645_02423	5.2e-07	51.2	COG1126@1|root,COG1126@2|Bacteria,2IYVK@203682|Planctomycetes	203682|Planctomycetes	E	ABC-type polar amino acid transport system ATPase component	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
k59_717424_2	1116472.MGMO_62c00020	1.01e-40	137.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,1S5XD@1236|Gammaproteobacteria,1XFIW@135618|Methylococcales	135618|Methylococcales	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
k59_717424_3	1123399.AQVE01000009_gene3072	1.02e-48	159.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,460K8@72273|Thiotrichales	72273|Thiotrichales	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
k59_1309826_1	225849.swp_1369	6.14e-27	108.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,2QAMK@267890|Shewanellaceae	1236|Gammaproteobacteria	P	PFAM sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_898680_1	472759.Nhal_0903	5.81e-60	207.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1WXI8@135613|Chromatiales	135613|Chromatiales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_1664713_1	933262.AXAM01000135_gene1054	4.96e-42	159.0	COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,43BJD@68525|delta/epsilon subdivisions,2WIZT@28221|Deltaproteobacteria,2MJCM@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase,MFS_1
k59_380923_1	713586.KB900536_gene217	6.95e-67	217.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1X01C@135613|Chromatiales	135613|Chromatiales	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	1.16.1.1	ko:K00520	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1194811_1	471853.Bcav_4212	1.12e-95	289.0	COG0492@1|root,COG0492@2|Bacteria,2GKD2@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1194811_2	935839.JAGJ01000015_gene2098	9.59e-47	153.0	COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria,4F4RX@85017|Promicromonosporaceae	201174|Actinobacteria	O	Thioredoxin	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_1194811_3	1043493.BBLU01000007_gene110	7.02e-05	44.3	COG1167@1|root,COG1167@2|Bacteria,2GITW@201174|Actinobacteria	201174|Actinobacteria	EK	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs	avtA	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
k59_265954_1	1408224.SAMCCGM7_c0497	2.18e-36	142.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,4BAKQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	CE	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
k59_313737_1	870187.Thini_4232	3.13e-151	441.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,460AR@72273|Thiotrichales	72273|Thiotrichales	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1258565_1	219305.MCAG_00187	2.76e-59	196.0	COG3842@1|root,COG3842@2|Bacteria,2H2JF@201174|Actinobacteria,4DB8Q@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	modC	-	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
k59_380933_2	56780.SYN_03523	1.91e-13	71.6	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42QX3@68525|delta/epsilon subdivisions,2WPC7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_1194819_1	395494.Galf_0515	2.27e-14	67.8	COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,2WAN7@28216|Betaproteobacteria,44W2Y@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Zinc-finger domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-CHCC
k59_1194819_2	1385515.N791_06775	2.97e-15	72.8	COG3642@1|root,COG3642@2|Bacteria	2|Bacteria	T	kinase activity	kdkA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15,2.7.1.166	ko:K02527,ko:K11211	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763,R09767	RC00002,RC00009,RC00077,RC00078,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Kdo
k59_1320439_1	582899.Hden_2309	5.33e-47	171.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,3N6H7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	PD-(D/E)XK nuclease superfamily	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
k59_1722152_1	519989.ECTPHS_06097	2.36e-54	194.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1WVXM@135613|Chromatiales	135613|Chromatiales	P	heavy metal translocating P-type ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_842036_1	762376.AXYL_02006	5.65e-16	84.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,3T2GX@506|Alcaligenaceae	28216|Betaproteobacteria	L	ATP-dependent helicase	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_780114_1	1049564.TevJSym_ad00370	9.67e-51	171.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,1J4Y7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009014,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0032153,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0046872,GO:0046914,GO:0050897,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_2485	M20_dimer,Peptidase_M20
k59_780114_2	713586.KB900536_gene148	9.24e-46	150.0	COG1393@1|root,COG1393@2|Bacteria,1MZ6S@1224|Proteobacteria,1S8TR@1236|Gammaproteobacteria,1WYR9@135613|Chromatiales	135613|Chromatiales	P	Belongs to the ArsC family	-	-	-	-	-	-	-	-	-	-	-	-	ArsC
k59_1848588_2	546262.NEICINOT_04149	2.32e-19	84.7	COG3686@1|root,COG3686@2|Bacteria,1MZP7@1224|Proteobacteria,2WFUG@28216|Betaproteobacteria,2KREW@206351|Neisseriales	206351|Neisseriales	S	Psort location CytoplasmicMembrane, score 9.46	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
k59_32210_1	314287.GB2207_04059	1.87e-32	132.0	COG0457@1|root,COG0457@2|Bacteria,1RC07@1224|Proteobacteria,1S36N@1236|Gammaproteobacteria,1J5XV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
k59_666221_1	857087.Metme_0593	7.3e-37	135.0	COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,1RRWT@1236|Gammaproteobacteria,1XE9X@135618|Methylococcales	135618|Methylococcales	G	PFAM Carbohydrate purine kinase	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_666221_2	631362.Thi970DRAFT_03306	2.59e-33	132.0	COG0438@1|root,COG0438@2|Bacteria,1QZ01@1224|Proteobacteria,1RZJA@1236|Gammaproteobacteria,1X05E@135613|Chromatiales	135613|Chromatiales	M	sucrose synthase	-	-	2.4.1.13	ko:K00695	ko00500,ko01100,map00500,map01100	-	R00806	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glycos_transf_1,Sucrose_synth
k59_137989_1	582515.KR51_00010670	4.99e-65	219.0	COG1505@1|root,COG1505@2|Bacteria,1G1B7@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_1546088_1	1116472.MGMO_64c00090	3.41e-05	47.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,1RN46@1236|Gammaproteobacteria,1XE6C@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,UPF0004
k59_1546088_3	1254432.SCE1572_01305	9.78e-21	84.7	COG0346@1|root,COG0346@2|Bacteria,1N08M@1224|Proteobacteria,434NI@68525|delta/epsilon subdivisions,2WYZV@28221|Deltaproteobacteria,2Z10X@29|Myxococcales	28221|Deltaproteobacteria	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_1780662_1	497964.CfE428DRAFT_0727	3.66e-81	257.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,46UC6@74201|Verrucomicrobia	74201|Verrucomicrobia	C	IMP dehydrogenase GMP reductase	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
k59_1493115_2	1288494.EBAPG3_12760	8.4e-60	191.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2VR8D@28216|Betaproteobacteria,372UU@32003|Nitrosomonadales	28216|Betaproteobacteria	CO	oxidoreductase DsbE	dsbE	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
k59_968227_1	1047013.AQSP01000098_gene2561	2.27e-33	120.0	COG0432@1|root,COG0432@2|Bacteria,2NPR7@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
k59_87410_1	631362.Thi970DRAFT_03785	1.33e-85	272.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1WW27@135613|Chromatiales	135613|Chromatiales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_909255_1	1249627.D779_0299	3.15e-96	301.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1WVYF@135613|Chromatiales	135613|Chromatiales	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1015027_1	1121365.AQXB01000003_gene112	9.92e-40	146.0	COG2865@1|root,COG2865@2|Bacteria,2I3IG@201174|Actinobacteria,22M2T@1653|Corynebacteriaceae	201174|Actinobacteria	K	Putative ATP-dependent DNA helicase recG C-terminal	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
k59_1015027_2	1229781.C272_05959	1.59e-15	72.0	COG0346@1|root,COG0346@2|Bacteria,2IHQQ@201174|Actinobacteria,4FAE7@85019|Brevibacteriaceae	201174|Actinobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_1546105_1	1123393.KB891328_gene702	2.18e-102	304.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2VKQ0@28216|Betaproteobacteria,1KSCI@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Transketolase, pyrimidine binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Transket_pyr,Transketolase_C
k59_909264_1	926566.Terro_2908	1.27e-09	65.1	COG0457@1|root,COG1225@1|root,COG0457@2|Bacteria,COG1225@2|Bacteria,3Y6YV@57723|Acidobacteria,2JKEW@204432|Acidobacteriia	204432|Acidobacteriia	O	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,TPR_11,TPR_2,TPR_8,UnbV_ASPIC,VCBS
k59_968238_1	472759.Nhal_2360	3.02e-17	80.9	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1WX0P@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_968238_3	754477.Q7C_1945	2.03e-49	171.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,46000@72273|Thiotrichales	72273|Thiotrichales	P	TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_1493132_1	240016.ABIZ01000001_gene5249	2.17e-105	335.0	COG0013@1|root,COG0013@2|Bacteria,46SAY@74201|Verrucomicrobia,2ITJJ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_1722182_1	722419.PH505_au00260	3.83e-122	379.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,2PZGC@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_313776_2	153496.JNAB01000044_gene1836	6.16e-07	52.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria,2JPD6@204441|Rhodospirillales	204441|Rhodospirillales	L	This protein is involved in the repair of mismatches in DNA	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_138010_1	177437.HRM2_05840	2.36e-88	267.0	29CPA@1|root,2ZZMJ@2|Bacteria,1QWMK@1224|Proteobacteria,43BCF@68525|delta/epsilon subdivisions,2X6RE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4338
k59_1085340_2	518766.Rmar_2305	2.63e-26	110.0	COG3174@1|root,COG3174@2|Bacteria,4NKP6@976|Bacteroidetes,1FJWC@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
k59_314570_1	1121396.KB893078_gene788	1.45e-26	107.0	2946W@1|root,2ZRMA@2|Bacteria	2|Bacteria	S	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1430743_1	272560.BPSL2485	1.06e-42	152.0	COG1270@1|root,COG1270@2|Bacteria,1MWCK@1224|Proteobacteria,2VH7X@28216|Betaproteobacteria,1K1N4@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
k59_1195698_2	1133850.SHJG_7468	4.21e-71	222.0	COG0500@1|root,COG2226@2|Bacteria,2GK7A@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
k59_1259614_1	1306174.JODP01000002_gene5888	6.41e-18	83.2	COG0330@1|root,COG0330@2|Bacteria,2GJ1U@201174|Actinobacteria	201174|Actinobacteria	O	PFAM Band 7 protein	hflK	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7
k59_1494050_1	1211115.ALIQ01000243_gene3766	2.17e-143	412.0	COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2TQVW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP,TAT_signal
k59_431617_1	314278.NB231_08315	1.17e-77	237.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_1430749_1	523845.AQXV01000050_gene969	5.78e-16	71.2	arCOG05874@1|root,arCOG05874@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_549018_1	446471.Xcel_1713	7.36e-76	235.0	COG0284@1|root,COG0284@2|Bacteria,2GKWK@201174|Actinobacteria,4F39V@85017|Promicromonosporaceae	201174|Actinobacteria	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_549018_2	1306174.JODP01000013_gene7502	1.02e-10	62.4	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria	201174|Actinobacteria	F	carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_490435_1	686340.Metal_1469	1.36e-49	166.0	2AQI0@1|root,31FQP@2|Bacteria,1RI31@1224|Proteobacteria,1S113@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_490435_2	1303518.CCALI_00738	2.78e-10	60.5	2EHSB@1|root,33BI2@2|Bacteria	2|Bacteria	S	SdpI/YhfL protein family	-	-	-	-	-	-	-	-	-	-	-	-	SdpI
k59_33745_1	1384056.N787_02590	8.28e-100	301.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RYRB@1236|Gammaproteobacteria,1XAD0@135614|Xanthomonadales	135614|Xanthomonadales	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_33745_2	1166018.FAES_2975	5.35e-55	186.0	COG1012@1|root,COG1012@2|Bacteria,4NFPJ@976|Bacteroidetes,47JJR@768503|Cytophagia	976|Bacteroidetes	C	Belongs to the aldehyde dehydrogenase family	pcd	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1665617_1	314278.NB231_05811	1.21e-112	336.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales	135613|Chromatiales	S	modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_382244_1	631362.Thi970DRAFT_00706	1.08e-57	201.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
k59_1321757_1	305700.B447_11152	1.36e-06	48.5	COG4117@1|root,COG4117@2|Bacteria,1R5GN@1224|Proteobacteria,2VP9C@28216|Betaproteobacteria,2KXEJ@206389|Rhodocyclales	206389|Rhodocyclales	C	Cytochrome b/b6/petB	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_1321757_2	1450694.BTS2_2257	2.95e-06	53.1	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,4HIQ3@91061|Bacilli,1ZCW1@1386|Bacillus	91061|Bacilli	CO	Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c	resA	GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_1015694_1	765913.ThidrDRAFT_2300	1.75e-22	91.3	COG5569@1|root,COG5569@2|Bacteria,1PU9Z@1224|Proteobacteria,1TB3P@1236|Gammaproteobacteria,1WZN7@135613|Chromatiales	135613|Chromatiales	S	Copper binding periplasmic protein CusF	-	-	-	-	-	-	-	-	-	-	-	-	CusF_Ec
k59_1195717_1	1463926.JOCA01000007_gene4156	7.26e-39	132.0	COG2764@1|root,COG2764@2|Bacteria,2IKY5@201174|Actinobacteria	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt,Glyoxalase
k59_1370901_1	696747.NIES39_A00440	2.14e-09	62.0	COG0457@1|root,COG0457@2|Bacteria,1GGS9@1117|Cyanobacteria	1117|Cyanobacteria	S	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21,TPR_11
k59_1370901_2	941449.dsx2_0370	2.61e-15	75.1	COG0641@1|root,COG0641@2|Bacteria	2|Bacteria	C	radical SAM	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
k59_138729_1	1121405.dsmv_0092	1.62e-25	110.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,42MFX@68525|delta/epsilon subdivisions,2WJ91@28221|Deltaproteobacteria,2MIXG@213118|Desulfobacterales	28221|Deltaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_33766_1	1401067.HMPREF0872_03080	5.23e-07	56.2	COG0860@1|root,COG0860@2|Bacteria,1UYPW@1239|Firmicutes,4H3ET@909932|Negativicutes	909932|Negativicutes	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
k59_1781390_1	1042377.AFPJ01000036_gene1233	1.78e-18	85.5	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_1195719_1	3067.XP_002947934.1	6.15e-53	171.0	COG2947@1|root,KOG3383@2759|Eukaryota,37UU7@33090|Viridiplantae,34HZR@3041|Chlorophyta	3041|Chlorophyta	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
k59_490447_1	765913.ThidrDRAFT_1029	1.25e-113	340.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1WW90@135613|Chromatiales	135613|Chromatiales	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_138731_1	690850.Desaf_0477	9.27e-48	168.0	COG2367@1|root,COG2367@2|Bacteria,1R4Y9@1224|Proteobacteria,42YC9@68525|delta/epsilon subdivisions,2WTSH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_607717_2	765912.Thimo_2542	3.74e-37	133.0	COG2913@1|root,COG2913@2|Bacteria,1N6YW@1224|Proteobacteria,1SCTT@1236|Gammaproteobacteria,1WZIB@135613|Chromatiales	135613|Chromatiales	J	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamE	-	-	ko:K06186	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	SmpA_OmlA
k59_1085380_1	35754.JNYJ01000035_gene3980	3.6e-07	51.6	COG1295@1|root,COG1295@2|Bacteria,2ICUY@201174|Actinobacteria,4DAYG@85008|Micromonosporales	201174|Actinobacteria	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
k59_1085380_2	1192034.CAP_1635	2.27e-35	134.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,42Z4I@68525|delta/epsilon subdivisions,2WUEY@28221|Deltaproteobacteria,2YW9D@29|Myxococcales	28221|Deltaproteobacteria	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
k59_314602_1	1156844.KB891820_gene354	9.61e-61	202.0	COG0624@1|root,COG0624@2|Bacteria,2GM84@201174|Actinobacteria	201174|Actinobacteria	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_382270_1	1476876.JOJO01000011_gene3189	6.61e-46	158.0	COG2378@1|root,COG2378@2|Bacteria,2GKTS@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
k59_1604997_1	446469.Sked_19960	7.09e-99	301.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_33792_1	1049564.TevJSym_bo00200	1.62e-101	309.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1N3PN@1224|Proteobacteria,1RNS0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Nitrite reductase	nirS	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_667004_1	396588.Tgr7_1832	1.86e-64	213.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WW5M@135613|Chromatiales	135613|Chromatiales	EH	Anthranilate synthase component I	-	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_667006_1	550540.Fbal_0107	4.75e-72	237.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_33801_1	768671.ThimaDRAFT_4579	1.35e-97	300.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1WXJT@135613|Chromatiales	135613|Chromatiales	F	Belongs to the 5'-nucleotidase family	-	-	-	ko:K17224	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	5_nucleotid_C
k59_1439139_1	1163409.UUA_08301	2.46e-64	222.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria,1X3GK@135614|Xanthomonadales	135614|Xanthomonadales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_16,TPR_19,TPR_8
k59_1731473_1	697282.Mettu_3066	3.11e-88	267.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1S2WI@1236|Gammaproteobacteria,1XEYK@135618|Methylococcales	135618|Methylococcales	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_147246_1	1122939.ATUD01000001_gene33	2.15e-41	154.0	COG2304@1|root,COG2304@2|Bacteria,2GKDC@201174|Actinobacteria	201174|Actinobacteria	O	Von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	ADP_ribosyl_GH,VWA
k59_1269175_1	394.NGR_c18010	1.03e-14	71.2	2DTA1@1|root,33JDA@2|Bacteria,1NHIN@1224|Proteobacteria,2UKS9@28211|Alphaproteobacteria,4BF9N@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
k59_1269175_2	765698.Mesci_6051	2.11e-32	120.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2TV0E@28211|Alphaproteobacteria,43J6T@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	catabolite gene activator and regulatory subunit of cAMP-dependent protein	fnrL	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	Crp,HTH_Crp_2,cNMP_binding
k59_1554980_2	926559.JoomaDRAFT_2577	7.81e-14	75.5	COG3900@1|root,COG3900@2|Bacteria,4NPSR@976|Bacteroidetes,1I206@117743|Flavobacteriia	976|Bacteroidetes	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
k59_323107_1	1026882.MAMP_01037	1.75e-68	222.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,46029@72273|Thiotrichales	72273|Thiotrichales	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_675550_1	105559.Nwat_1664	1.35e-14	75.9	2C6BU@1|root,32S87@2|Bacteria,1NIFE@1224|Proteobacteria,1SFM9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1554985_1	240015.ACP_2515	4.56e-09	57.0	COG0366@1|root,COG0366@2|Bacteria,3Y3QT@57723|Acidobacteria,2JI2C@204432|Acidobacteriia	204432|Acidobacteriia	G	Alpha-amylase domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_1613202_1	1267005.KB911255_gene2879	1.07e-151	449.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2USBB@28211|Alphaproteobacteria,3N6HJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	penicillin-binding protein	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_1674095_1	1304275.C41B8_12365	6.01e-69	229.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_1503556_1	1121405.dsmv_3000	4.1e-27	108.0	COG0674@1|root,COG0674@2|Bacteria,1R4K0@1224|Proteobacteria,42NQJ@68525|delta/epsilon subdivisions,2WJ0K@28221|Deltaproteobacteria,2MIND@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_1503556_2	1121405.dsmv_2999	1.21e-59	196.0	COG1013@1|root,COG1014@1|root,COG1013@2|Bacteria,COG1014@2|Bacteria,1R7US@1224|Proteobacteria,42PFT@68525|delta/epsilon subdivisions,2WMBJ@28221|Deltaproteobacteria,2MJ1Z@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,TPP_enzyme_C
k59_1269184_1	1232683.ADIMK_3980	1.5e-130	384.0	COG1493@1|root,COG1493@2|Bacteria,1R0JS@1224|Proteobacteria,1T2N5@1236|Gammaproteobacteria,46A1F@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	HPr kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_397003_1	765910.MARPU_00830	0.00039	42.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWJ6@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_397003_2	572477.Alvin_1510	6.88e-46	157.0	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,1RMP3@1236|Gammaproteobacteria,1WWKK@135613|Chromatiales	135613|Chromatiales	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
k59_103471_1	768671.ThimaDRAFT_4015	3.49e-191	545.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1WWGN@135613|Chromatiales	135613|Chromatiales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_498917_1	768671.ThimaDRAFT_2229	6.67e-81	268.0	COG0439@1|root,COG1984@1|root,COG2049@1|root,COG4770@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,COG4770@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,1WX8J@135613|Chromatiales	135613|Chromatiales	EI	Allophanate hydrolase subunit 1	-	-	6.3.4.6	ko:K01941	ko00220,ko00791,ko01100,map00220,map00791,map01100	-	R00774	RC00378	ko00000,ko00001,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D
k59_1674104_1	1304865.JAGF01000001_gene2895	1.4e-126	372.0	COG0423@1|root,COG0423@2|Bacteria,2GIT3@201174|Actinobacteria,4F0Q9@85016|Cellulomonadaceae	201174|Actinobacteria	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
k59_787887_1	2340.JV46_16550	1.18e-106	320.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1J53B@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Aminotransferase	hemL	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iUMNK88_1353.UMNK88_158	Aminotran_3
k59_1555004_1	395493.BegalDRAFT_1138	1.42e-23	105.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,45ZXV@72273|Thiotrichales	72273|Thiotrichales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_675574_1	1380354.JIAN01000005_gene1813	4.5e-76	241.0	COG0354@1|root,COG0354@2|Bacteria,2GKP0@201174|Actinobacteria,4F0XW@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM glycine cleavage T protein (aminomethyl transferase)	ygfZ	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
k59_147280_1	911239.CF149_03579	4.69e-32	119.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,1RSHS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_0821,iECIAI1_1343.ECIAI1_0813,iECO103_1326.ECO103_0813,iECO111_1330.ECO111_0839,iECO26_1355.ECO26_0904,iECSE_1348.ECSE_0831,iECW_1372.ECW_m0833,iEKO11_1354.EKO11_3108,iEcE24377_1341.EcE24377A_0841,iSFV_1184.SFV_0761,iSSON_1240.SSON_0757,iWFL_1372.ECW_m0833,ic_1306.c0858	AAA_26
k59_323141_1	56780.SYN_00688	3.55e-71	223.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,42N0U@68525|delta/epsilon subdivisions,2WJH3@28221|Deltaproteobacteria,2MR1K@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
k59_278844_1	573370.DMR_33550	4.04e-68	223.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,42MGF@68525|delta/epsilon subdivisions,2WJMB@28221|Deltaproteobacteria,2M9H9@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM Carboxylyase-related protein	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_1141326_1	1232437.KL662010_gene1597	3.85e-90	270.0	COG0138@1|root,COG0138@2|Bacteria,1N2UC@1224|Proteobacteria,42NFS@68525|delta/epsilon subdivisions,2X5JJ@28221|Deltaproteobacteria,2MIV7@213118|Desulfobacterales	28221|Deltaproteobacteria	F	MGS-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AICARFT_IMPCHas,MGS
k59_851243_1	572477.Alvin_2150	4.45e-13	67.4	COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria,1WVWS@135613|Chromatiales	135613|Chromatiales	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	apaH	-	3.6.1.41	ko:K01525	ko00230,map00230	-	R00125	RC00002	ko00000,ko00001,ko01000	-	-	-	Metallophos
k59_851243_2	713586.KB900536_gene2631	1.16e-57	182.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1WYSF@135613|Chromatiales	135613|Chromatiales	P	PFAM ApaG domain protein	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
k59_557523_1	1198232.CYCME_0638	1.7e-39	142.0	COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,1S8S0@1236|Gammaproteobacteria,462X5@72273|Thiotrichales	72273|Thiotrichales	S	SURF1 family	-	-	-	-	-	-	-	-	-	-	-	-	SURF1
k59_1269214_1	96561.Dole_1592	6.08e-71	228.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,42NIG@68525|delta/epsilon subdivisions,2WIR1@28221|Deltaproteobacteria,2MHMV@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k59_440249_1	765912.Thimo_3262	9.27e-83	253.0	COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria,1WVWS@135613|Chromatiales	135613|Chromatiales	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	apaH	-	3.6.1.41	ko:K01525	ko00230,map00230	-	R00125	RC00002	ko00000,ko00001,ko01000	-	-	-	Metallophos
k59_440249_2	713586.KB900536_gene2631	1.13e-51	166.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1WYSF@135613|Chromatiales	135613|Chromatiales	P	PFAM ApaG domain protein	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
k59_440249_3	335283.Neut_2476	7.24e-09	56.2	COG0589@1|root,COG0589@2|Bacteria,1RHE6@1224|Proteobacteria,2WBHY@28216|Betaproteobacteria,3735U@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Universal stress protein	-	-	-	ko:K06149	-	-	-	-	ko00000	-	-	-	Usp
k59_1865071_2	1158150.KB906249_gene2429	8.41e-55	174.0	COG1403@1|root,COG1403@2|Bacteria,1RGZQ@1224|Proteobacteria,1S5V4@1236|Gammaproteobacteria,1WYBY@135613|Chromatiales	135613|Chromatiales	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH
k59_103530_1	290397.Adeh_1774	6.28e-87	276.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJZ3@28221|Deltaproteobacteria,2YXF9@29|Myxococcales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1022795_1	795666.MW7_2523	2.69e-41	149.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2VH8Z@28216|Betaproteobacteria,1K27M@119060|Burkholderiaceae	28216|Betaproteobacteria	E	gamma-glutamyltransferase	ggt1	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1022795_2	420662.Mpe_A0013	4.02e-15	68.6	2CIC8@1|root,33JK4@2|Bacteria,1NH5Z@1224|Proteobacteria,2VYDU@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1731532_1	248742.XP_005646493.1	5.58e-11	68.6	COG0637@1|root,KOG2177@1|root,KOG2177@2759|Eukaryota,KOG2914@2759|Eukaryota,37MAK@33090|Viridiplantae,34J68@3041|Chlorophyta	3041|Chlorophyta	O	NHL repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL,Thioredoxin_8
k59_925504_1	1288826.MSNKSG1_03700	1.36e-90	286.0	COG1028@1|root,COG3320@1|root,COG1028@2|Bacteria,COG3320@2|Bacteria,1QSHC@1224|Proteobacteria,1RQP8@1236|Gammaproteobacteria,465Q8@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4,adh_short
k59_1731534_1	135651.CBN17254	7.22e-59	206.0	COG0058@1|root,KOG2099@2759|Eukaryota,38F0I@33154|Opisthokonta,3BD45@33208|Metazoa,3CSQ6@33213|Bilateria,40BPS@6231|Nematoda,1KTUM@119089|Chromadorea,40TAU@6236|Rhabditida	33208|Metazoa	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_557534_1	1123261.AXDW01000001_gene1445	2.4e-88	267.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1X2X9@135614|Xanthomonadales	135614|Xanthomonadales	V	Part of the ABC transporter complex LolCDE involved in the translocation of	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
k59_1613246_1	1288826.MSNKSG1_05161	7.07e-69	224.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,463YH@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	lpdG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iE2348C_1286.E2348C_4372,iJN746.PP_4187	Pyr_redox_2,Pyr_redox_dim
k59_1865085_1	649831.L083_0359	8.96e-37	135.0	2BXAC@1|root,2Z85S@2|Bacteria,2I8IX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1336815_1	232721.Ajs_3918	2.97e-133	389.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VK9J@28216|Betaproteobacteria,4AB5J@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_1094937_1	1163617.SCD_n02577	4.31e-40	145.0	COG0697@1|root,COG0697@2|Bacteria,1MXJ6@1224|Proteobacteria,2VIA7@28216|Betaproteobacteria	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1141343_1	1123321.KB905819_gene5810	3.25e-07	53.1	2D19V@1|root,32TA6@2|Bacteria,2IRPX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_984627_1	443144.GM21_0781	3.39e-131	387.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,42M2M@68525|delta/epsilon subdivisions,2WJ5H@28221|Deltaproteobacteria,43TA3@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
k59_1022804_1	1172188.KB911825_gene3637	1.08e-68	229.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4FG7R@85021|Intrasporangiaceae	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
k59_984629_1	1267535.KB906767_gene5049	2.04e-12	67.0	COG1587@1|root,COG1587@2|Bacteria,3Y4W1@57723|Acidobacteria,2JJFE@204432|Acidobacteriia	204432|Acidobacteriia	H	synthase	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
k59_984629_2	876044.IMCC3088_384	1.74e-33	125.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1J4EA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_4275,iECH74115_1262.ECH74115_5243,iECIAI1_1343.ECIAI1_3991,iECO103_1326.ECO103_4362,iECO111_1330.ECO111_4628,iECO26_1355.ECO26_4784,iECSE_1348.ECSE_4086,iEKO11_1354.EKO11_4554,iPC815.YPO3849	Porphobil_deam,Porphobil_deamC
k59_734236_1	1122212.AULO01000013_gene2038	6.04e-48	166.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,1RPE2@1236|Gammaproteobacteria,1XHX3@135619|Oceanospirillales	135619|Oceanospirillales	I	enoyl-CoA hydratase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
k59_1204101_2	378806.STAUR_2600	4.7e-46	173.0	2A4HQ@1|root,30T49@2|Bacteria,1PCRR@1224|Proteobacteria,438KR@68525|delta/epsilon subdivisions,2X3V4@28221|Deltaproteobacteria,2YX7F@29|Myxococcales	28221|Deltaproteobacteria	S	phage tail protein	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
k59_557547_1	324925.Ppha_1460	6.23e-78	245.0	COG0420@1|root,COG0420@2|Bacteria	2|Bacteria	L	3'-5' exonuclease activity	yhaO	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2
k59_1731550_1	1348657.M622_05550	9.74e-70	229.0	COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria,2WHHS@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
k59_1269238_2	68570.DC74_5412	2.58e-41	142.0	COG0239@1|root,COG0239@2|Bacteria,2IKM1@201174|Actinobacteria	201174|Actinobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
k59_103565_1	1121441.AUCX01000012_gene3331	1.34e-42	148.0	COG0035@1|root,COG0035@2|Bacteria,1MV4N@1224|Proteobacteria,42NNR@68525|delta/epsilon subdivisions,2WK6M@28221|Deltaproteobacteria,2M9CT@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
k59_1336838_1	1082705.JIBP01000012_gene2121	1.59e-29	111.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1S610@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate	tsaC	GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061710,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
k59_1336838_2	1415780.JPOG01000001_gene3357	5.75e-42	147.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1X3RT@135614|Xanthomonadales	135614|Xanthomonadales	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
k59_47267_2	1163617.SCD_n02930	1.15e-20	89.4	COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,2VRJN@28216|Betaproteobacteria	28216|Betaproteobacteria	S	associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
k59_676591_1	398525.KB900701_gene708	1.18e-118	349.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,3JU80@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,rve
k59_47268_1	1282876.BAOK01000001_gene3563	7.14e-67	206.0	28NR0@1|root,2ZBQD@2|Bacteria,1RA2I@1224|Proteobacteria,2U5BA@28211|Alphaproteobacteria,4BQCU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Nucleoside 2-deoxyribosyltransferase YtoQ	ytoQ	-	-	-	-	-	-	-	-	-	-	-	Nuc_deoxyri_tr3
k59_1866654_1	96561.Dole_0921	1.29e-90	272.0	COG1266@1|root,COG1266@2|Bacteria,1MWXT@1224|Proteobacteria,42XZG@68525|delta/epsilon subdivisions,2WSV7@28221|Deltaproteobacteria,2MMZG@213118|Desulfobacterales	28221|Deltaproteobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_206878_1	631362.Thi970DRAFT_03988	5.07e-62	204.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1WWK5@135613|Chromatiales	135613|Chromatiales	O	FeS assembly protein SufD	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_206878_2	940282.CADQ01000012_gene2716	3.31e-16	75.1	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2U72U@28211|Alphaproteobacteria,2JT8V@204441|Rhodospirillales	204441|Rhodospirillales	S	Iron-sulfur cluster assembly protein	sufT	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
k59_1338409_1	644282.Deba_0881	1.73e-76	244.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM carboxyl transferase	pccB	-	2.1.3.1,2.1.3.15,6.4.1.3	ko:K01966,ko:K17489	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R00353,R01859	RC00040,RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_148305_1	1267005.KB911257_gene742	2.96e-156	450.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2TRXC@28211|Alphaproteobacteria,3N6AM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_1675152_1	1317118.ATO8_18175	8.33e-148	428.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1675152_2	1317118.ATO8_18180	2.56e-99	293.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TS16@28211|Alphaproteobacteria,4KNWZ@93682|Roseivivax	28211|Alphaproteobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_324126_1	1089455.MOPEL_073_01370	3.9e-95	290.0	COG5016@1|root,COG5016@2|Bacteria,2IASR@201174|Actinobacteria,4F617@85018|Dermatophilaceae	201174|Actinobacteria	C	Conserved carboxylase domain	oadA	-	2.1.3.1	ko:K03416	ko00640,map00640	-	R00353,R00930	RC00040,RC00097	ko00000,ko00001,ko01000	-	-	-	HMGL-like,PYC_OADA
k59_676601_1	381666.H16_A2758	4.68e-105	319.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2VHJB@28216|Betaproteobacteria,1K0EB@119060|Burkholderiaceae	28216|Betaproteobacteria	G	PFAM D-galactarate dehydratase Altronate hydrolase domain protein	-	-	4.2.1.42,4.2.1.7,4.4.1.24	ko:K01685,ko:K01708,ko:K16846	ko00040,ko00053,ko00270,ko01100,map00040,map00053,map00270,map01100	M00631	R01540,R05608,R07633	RC00543,RC01785	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
k59_1096052_2	243233.MCA3086	3.15e-10	64.7	COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1XEC7@135618|Methylococcales	135618|Methylococcales	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	TPR_1,TPR_2,VWA_2
k59_617111_1	367299.JOEE01000002_gene2593	6.04e-69	215.0	COG0454@1|root,COG0456@2|Bacteria,2GMPX@201174|Actinobacteria,4FHW6@85021|Intrasporangiaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,FR47
k59_1440229_1	1267005.KB911256_gene1873	2.26e-113	332.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TU4H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
k59_617117_1	1380394.JADL01000005_gene5530	4.85e-10	63.9	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2TS8U@28211|Alphaproteobacteria,2JPQ0@204441|Rhodospirillales	204441|Rhodospirillales	I	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
k59_58406_1	425104.Ssed_1391	3.07e-120	354.0	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,1RPAE@1236|Gammaproteobacteria,2QCQW@267890|Shewanellaceae	1236|Gammaproteobacteria	T	PFAM UspA domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1513390_1	204773.HEAR0175	1.63e-23	103.0	COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,2VSUT@28216|Betaproteobacteria,473G5@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	LppC putative lipoprotein	-	-	-	ko:K07121	-	-	-	-	ko00000	-	-	-	LppC
k59_1212612_1	1266925.JHVX01000001_gene2640	3.58e-53	178.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2VHCB@28216|Betaproteobacteria,371T5@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
k59_116999_1	639283.Snov_0748	3.18e-20	90.9	COG1767@1|root,COG1767@2|Bacteria,1RAWI@1224|Proteobacteria,2U5HF@28211|Alphaproteobacteria,3EY28@335928|Xanthobacteraceae	28211|Alphaproteobacteria	H	ATP:dephospho-CoA triphosphoribosyl transferase	-	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
k59_507863_1	640511.BC1002_6327	3.91e-06	48.5	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2VP1W@28216|Betaproteobacteria,1KCPK@119060|Burkholderiaceae	28216|Betaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_507863_2	870187.Thini_0564	6.65e-90	273.0	COG0650@1|root,COG0650@2|Bacteria,1QE37@1224|Proteobacteria,1RZJC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	pfam nadh	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_997938_1	232348.ADXL01000058_gene2405	4.27e-64	209.0	COG1875@1|root,COG1875@2|Bacteria,1G3BE@1117|Cyanobacteria,1GYJU@1129|Synechococcus	1117|Cyanobacteria	T	ATPase related to phosphate starvation-inducible protein PhoH	-	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
k59_938694_1	1463885.KL578472_gene4101	4.24e-14	69.7	2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
k59_997951_1	1267005.KB911256_gene2038	4.91e-68	226.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,3N6ES@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	ABC transporter	abcT3	-	-	ko:K06147,ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1796486_1	367299.JOEE01000004_gene1040	2.4e-149	439.0	COG0366@1|root,COG0366@2|Bacteria,2GJKR@201174|Actinobacteria,4FEI1@85021|Intrasporangiaceae	201174|Actinobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_410573_1	1121406.JAEX01000005_gene2879	9.66e-88	281.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria,2M9AS@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Formate dehydrogenase, alpha subunit	fdnG-2	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_1213795_2	338963.Pcar_0451	1.17e-51	172.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,42U8G@68525|delta/epsilon subdivisions,2WQPS@28221|Deltaproteobacteria,43UX2@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	MlaC protein	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
k59_1213795_3	1232410.KI421418_gene2437	7e-09	55.5	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,42RII@68525|delta/epsilon subdivisions,2WNS9@28221|Deltaproteobacteria,43SIS@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	MlaA lipoprotein	-	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
k59_1389143_1	1283300.ATXB01000001_gene1010	2.72e-65	212.0	COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,1RZ41@1236|Gammaproteobacteria,1XEKE@135618|Methylococcales	1236|Gammaproteobacteria	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_1389143_2	1279019.ARQK01000047_gene1047	1.5e-54	174.0	COG3118@1|root,COG3118@2|Bacteria,1RHRZ@1224|Proteobacteria,1S7F0@1236|Gammaproteobacteria,1WYEG@135613|Chromatiales	135613|Chromatiales	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_860983_1	765911.Thivi_0061	1.15e-66	222.0	COG0589@1|root,COG0730@1|root,COG0589@2|Bacteria,COG0730@2|Bacteria,1NBKV@1224|Proteobacteria,1SHMY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Universal stress protein family	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE,Usp
k59_1564923_1	926569.ANT_04650	7.45e-99	300.0	COG0031@1|root,COG0031@2|Bacteria,2G8GE@200795|Chloroflexi	200795|Chloroflexi	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
k59_333527_1	518766.Rmar_2208	8.94e-81	257.0	COG1960@1|root,COG1960@2|Bacteria,4NEM4@976|Bacteroidetes,1FJQH@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
k59_1106259_1	566466.NOR53_2748	1.85e-30	120.0	COG3568@1|root,COG3568@2|Bacteria,1RJZP@1224|Proteobacteria,1TH72@1236|Gammaproteobacteria,1JABN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_215836_1	765869.BDW_03705	1.18e-29	115.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,43BC4@68525|delta/epsilon subdivisions,2X6R6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
k59_215836_2	765912.Thimo_2416	1.15e-05	47.4	COG0419@1|root,COG4717@1|root,COG0419@2|Bacteria,COG4717@2|Bacteria,1MVAW@1224|Proteobacteria,1RZFW@1236|Gammaproteobacteria,1WX3B@135613|Chromatiales	135613|Chromatiales	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_27
k59_292939_2	545276.KB898728_gene233	2.01e-32	118.0	COG0589@1|root,COG0589@2|Bacteria,1N13N@1224|Proteobacteria,1S9AN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_626338_1	472759.Nhal_2557	9.05e-11	62.0	COG1295@1|root,COG1295@2|Bacteria,1NH82@1224|Proteobacteria,1S3T8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ribonuclease BN	-	-	-	-	-	-	-	-	-	-	-	-	Virul_fac_BrkB
k59_626338_2	998674.ATTE01000001_gene319	0.000896	42.7	COG2010@1|root,COG2010@2|Bacteria,1N71Z@1224|Proteobacteria,1SH2C@1236|Gammaproteobacteria,461FB@72273|Thiotrichales	72273|Thiotrichales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_626338_3	396588.Tgr7_0189	1.13e-40	143.0	COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,1S739@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
k59_795956_1	1163389.OOM_0124	1.88e-20	88.2	COG3017@1|root,COG3017@2|Bacteria,1N02T@1224|Proteobacteria,1S91E@1236|Gammaproteobacteria,4617Y@72273|Thiotrichales	72273|Thiotrichales	M	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein	lolB	-	-	ko:K02494	-	-	-	-	ko00000	-	-	-	LolB
k59_795956_2	748658.KB907316_gene501	1.99e-15	75.1	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria,1WX6F@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_1684059_1	1380354.JIAN01000006_gene528	7.33e-57	194.0	COG0815@1|root,COG0815@2|Bacteria,2GJ9F@201174|Actinobacteria,4F0G7@85016|Cellulomonadaceae	201174|Actinobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_1684059_2	471853.Bcav_2065	8.2e-111	327.0	COG1216@1|root,COG1216@2|Bacteria,2I2FA@201174|Actinobacteria	201174|Actinobacteria	H	PFAM Glycosyl transferase family 2	ppm1	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
k59_1684059_3	935839.JAGJ01000003_gene1553	5.48e-55	174.0	2CNY9@1|root,31ED6@2|Bacteria,2I80T@201174|Actinobacteria,4F4JE@85017|Promicromonosporaceae	201174|Actinobacteria	K	Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters	rbpA	-	-	-	-	-	-	-	-	-	-	-	RbpA
k59_509112_1	755731.Clo1100_0058	8.14e-18	85.1	COG1597@1|root,COG1597@2|Bacteria,1V1DP@1239|Firmicutes,25CN2@186801|Clostridia,36HD9@31979|Clostridiaceae	186801|Clostridia	I	Diacylglycerol kinase catalytic domain (presumed)	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
k59_1741912_1	506534.Rhein_0255	4.43e-98	305.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1WXBH@135613|Chromatiales	135613|Chromatiales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_1623160_1	929556.Solca_1837	3.95e-41	145.0	COG4461@1|root,COG4461@2|Bacteria,4NIBZ@976|Bacteroidetes,1J0FI@117747|Sphingobacteriia	976|Bacteroidetes	G	4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PliI
k59_1797496_1	56780.SYN_01247	7.21e-35	121.0	2DCXT@1|root,2ZFR8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_685842_2	593907.Celgi_2001	2.46e-22	93.2	COG2919@1|root,COG2919@2|Bacteria,2GW5Q@201174|Actinobacteria,4F1K5@85016|Cellulomonadaceae	201174|Actinobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_292995_1	161528.ED21_28098	9.27e-35	127.0	COG0500@1|root,COG2226@2|Bacteria,1RANW@1224|Proteobacteria,2U66N@28211|Alphaproteobacteria,2K411@204457|Sphingomonadales	204457|Sphingomonadales	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
k59_1106318_1	1244869.H261_17908	2.06e-17	82.4	COG0745@1|root,COG2200@1|root,COG0745@2|Bacteria,COG2200@2|Bacteria,1NWAF@1224|Proteobacteria	1224|Proteobacteria	T	Response regulator, receiver	-	-	3.1.4.52	ko:K13246	ko05111,map05111	-	R08991	RC00296	ko00000,ko00001,ko01000	-	-	-	EAL,GGDEF,GerE,HD,HTH_18,HWE_HK,HisKA_2,PAS,PAS_3,PAS_9,Response_reg,SpoIIE,Trans_reg_C
k59_1106318_2	1234364.AMSF01000059_gene950	3.02e-43	145.0	COG1522@1|root,COG1522@2|Bacteria,1RJK0@1224|Proteobacteria,1S6HD@1236|Gammaproteobacteria,1X6QR@135614|Xanthomonadales	135614|Xanthomonadales	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
k59_1033206_1	765910.MARPU_10625	3.07e-77	257.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales	135613|Chromatiales	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HTH_12,OB_RNB,RNB,S1
k59_1741942_1	1134474.O59_002289	1.78e-97	305.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1FGW9@10|Cellvibrio	1236|Gammaproteobacteria	D	Ftsk_gamma	ftsK	GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1280715_1	1348657.M622_15780	7.04e-69	219.0	COG0265@1|root,COG0265@2|Bacteria,1R9ZV@1224|Proteobacteria,2VQ55@28216|Betaproteobacteria,2KW3P@206389|Rhodocyclales	206389|Rhodocyclales	O	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
k59_1033219_1	224914.BMEI0837	2.67e-123	368.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRSU@28211|Alphaproteobacteria,1J268@118882|Brucellaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_1389232_1	326297.Sama_0831	3.66e-66	210.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,1RQQT@1236|Gammaproteobacteria,2Q8WF@267890|Shewanellaceae	1236|Gammaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
k59_1389232_2	1268635.Loa_02934	4.01e-05	44.3	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,1RYCJ@1236|Gammaproteobacteria,1JCPM@118969|Legionellales	118969|Legionellales	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
k59_450444_1	1121405.dsmv_2919	7.73e-56	177.0	COG4109@1|root,COG4109@2|Bacteria,1N96M@1224|Proteobacteria,42V82@68525|delta/epsilon subdivisions,2WS7X@28221|Deltaproteobacteria,2MNU8@213118|Desulfobacterales	28221|Deltaproteobacteria	K	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
k59_509164_1	1122603.ATVI01000005_gene3042	4.67e-35	134.0	COG0668@1|root,COG0668@2|Bacteria,1N4UN@1224|Proteobacteria,1T9TX@1236|Gammaproteobacteria,1XBUR@135614|Xanthomonadales	135614|Xanthomonadales	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
k59_796004_1	1260251.SPISAL_03990	2.69e-118	354.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1WX2I@135613|Chromatiales	135613|Chromatiales	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
k59_796007_2	936136.ARRT01000006_gene3676	6.98e-24	100.0	COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,2U874@28211|Alphaproteobacteria,4B9DE@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2
k59_1684141_1	309799.DICTH_0291	1.4e-30	120.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
k59_1449151_2	42256.RradSPS_2354	1.28e-34	125.0	COG4405@1|root,COG4405@2|Bacteria,2IKQP@201174|Actinobacteria	201174|Actinobacteria	I	ASCH	-	-	-	-	-	-	-	-	-	-	-	-	ASCH
k59_450464_1	1163617.SCD_n00781	7.41e-71	226.0	COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,2VKGG@28216|Betaproteobacteria	28216|Betaproteobacteria	S	transporter component	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_626425_2	2340.JV46_21830	1.29e-31	117.0	2DP15@1|root,3303T@2|Bacteria,1N7NN@1224|Proteobacteria,1S90P@1236|Gammaproteobacteria,1J6SN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4426)	PP5099	-	-	-	-	-	-	-	-	-	-	-	DUF4426
k59_1213925_1	1232437.KL662012_gene1428	1.04e-94	289.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2WJE2@28221|Deltaproteobacteria,2MISS@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_1449156_1	765913.ThidrDRAFT_0066	3.95e-15	73.6	COG0500@1|root,COG2226@2|Bacteria,1RDI3@1224|Proteobacteria,1SZC2@1236|Gammaproteobacteria,1X2EH@135613|Chromatiales	135613|Chromatiales	Q	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
k59_1449156_2	414684.RC1_3515	4.17e-57	192.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,2TQMP@28211|Alphaproteobacteria,2JPVA@204441|Rhodospirillales	204441|Rhodospirillales	G	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor	otsA	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
k59_1213926_1	446470.Snas_4864	1.29e-71	228.0	COG1915@1|root,COG1915@2|Bacteria,2GMEZ@201174|Actinobacteria,4EY0H@85014|Glycomycetales	201174|Actinobacteria	S	LOR/SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
k59_1150435_1	743721.Psesu_0805	3.8e-76	242.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1X3MI@135614|Xanthomonadales	135614|Xanthomonadales	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_1033262_1	765910.MARPU_10625	4.24e-23	100.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales	135613|Chromatiales	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HTH_12,OB_RNB,RNB,S1
k59_861118_1	1122604.JONR01000023_gene4152	2.9e-14	72.8	COG0475@1|root,COG0475@2|Bacteria,1QTSD@1224|Proteobacteria,1T1FK@1236|Gammaproteobacteria,1XDAV@135614|Xanthomonadales	135614|Xanthomonadales	P	Kef-type K transport	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
k59_861118_2	1411685.U062_02068	1.57e-30	119.0	COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,1J4NN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Succinylglutamate desuccinylase aspartoacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
k59_744608_1	880072.Desac_0544	5.56e-103	330.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MSJC@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	por	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_509198_1	386456.JQKN01000001_gene2335	5.51e-09	63.5	COG0842@1|root,arCOG01463@2157|Archaea	2157|Archaea	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_567697_1	1457393.AZ09_07475	3.22e-69	228.0	COG2317@1|root,COG2317@2|Bacteria,1MW7T@1224|Proteobacteria,2TSMY@28211|Alphaproteobacteria,2JP9Q@204441|Rhodospirillales	204441|Rhodospirillales	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
k59_293055_1	1198232.CYCME_0634	2.19e-113	335.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,460BG@72273|Thiotrichales	72273|Thiotrichales	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	cyoA	-	1.10.3.10,1.9.3.1	ko:K02275,ko:K02297	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081,R11335	RC00016,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX2,COX2_TM,COX_ARM
k59_1389294_1	1267535.KB906767_gene447	1.32e-72	240.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria,2JMN2@204432|Acidobacteriia	204432|Acidobacteriia	T	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12
k59_1623270_1	999541.bgla_1g32730	1.8e-85	262.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2VHUJ@28216|Betaproteobacteria,1K1GV@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
k59_215954_1	680646.RMDY18_01550	1.24e-05	47.8	COG0294@1|root,COG0294@2|Bacteria,2GJDQ@201174|Actinobacteria,1W7GZ@1268|Micrococcaceae	201174|Actinobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
k59_215954_2	446469.Sked_32060	2.94e-34	134.0	COG0801@1|root,COG1539@1|root,COG0801@2|Bacteria,COG1539@2|Bacteria,2H3G6@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
k59_1565082_1	765912.Thimo_1677	8.31e-93	282.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1WWZ0@135613|Chromatiales	135613|Chromatiales	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_1565082_2	977880.RALTA_A0944	2.5e-12	67.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2VHBB@28216|Betaproteobacteria,1K01J@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	hemN2	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_215959_1	555778.Hneap_0971	1.77e-98	311.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_1150469_1	1449337.JQLL01000001_gene1460	9.06e-41	155.0	COG1461@1|root,COG1461@2|Bacteria,1TR6J@1239|Firmicutes,4HC2T@91061|Bacilli,27FTN@186828|Carnobacteriaceae	91061|Bacilli	S	Dak2	yfhG	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak2,DegV
k59_796053_1	472759.Nhal_0521	9.08e-62	214.0	COG2203@1|root,COG3829@1|root,COG5001@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales	135613|Chromatiales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_4,PAS_9
k59_1106420_1	686340.Metal_3276	1.27e-78	238.0	2DKVG@1|root,30GRY@2|Bacteria,1RDQT@1224|Proteobacteria,1S80C@1236|Gammaproteobacteria,1XFEZ@135618|Methylococcales	135618|Methylococcales	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
k59_1106420_2	1198114.AciX9_1635	1.43e-79	250.0	COG0657@1|root,COG0657@2|Bacteria	2|Bacteria	I	acetylesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Abhydrolase_6,Peptidase_S9
k59_1106420_3	720555.BATR1942_15215	1.65e-57	187.0	COG4977@1|root,COG4977@2|Bacteria,1TXM2@1239|Firmicutes,4HCAA@91061|Bacilli,1ZGZJ@1386|Bacillus	91061|Bacilli	K	intracellular protease amidase	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
k59_333699_1	396588.Tgr7_3073	6.78e-57	191.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMFM@1236|Gammaproteobacteria,1WXWQ@135613|Chromatiales	135613|Chromatiales	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k59_643430_1	314256.OG2516_18440	2.82e-39	150.0	COG2931@1|root,COG3210@1|root,COG4070@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria,2V8V8@28211|Alphaproteobacteria,2PFGF@252301|Oceanicola	28211|Alphaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1467003_1	189753.AXAS01000031_gene4410	1.55e-05	48.5	COG0672@1|root,COG0672@2|Bacteria,1MX1M@1224|Proteobacteria,2TU8Z@28211|Alphaproteobacteria,3JW7C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Iron permease FTR1 family	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
k59_1467003_2	754476.Q7A_1978	5.81e-44	145.0	COG4633@1|root,COG4633@2|Bacteria,1N6VB@1224|Proteobacteria,1SDG5@1236|Gammaproteobacteria,4619I@72273|Thiotrichales	72273|Thiotrichales	S	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
k59_1467003_3	1168065.DOK_17540	1.57e-31	123.0	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,1T1G3@1236|Gammaproteobacteria,1JC2S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Two-component sensor kinase N-terminal	qseC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K07645	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
k59_643446_1	1127673.GLIP_1996	3.51e-46	169.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D9@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	mdtB	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_524417_1	1304865.JAGF01000001_gene2856	1.77e-18	85.1	COG3239@1|root,COG3239@2|Bacteria,2GJKF@201174|Actinobacteria,4F1WW@85016|Cellulomonadaceae	201174|Actinobacteria	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
k59_524417_2	562973.HMPREF0059_01147	5.04e-16	71.2	COG1937@1|root,COG1937@2|Bacteria,2IQAC@201174|Actinobacteria,4D5YI@85005|Actinomycetales	201174|Actinobacteria	S	Metal-sensitive transcriptional repressor	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
k59_810783_2	207954.MED92_15830	1.45e-17	83.6	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1XHGA@135619|Oceanospirillales	135619|Oceanospirillales	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_583961_1	1869.MB27_16915	1.46e-48	164.0	COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria,4DBIF@85008|Micromonosporales	201174|Actinobacteria	IQ	KR domain	-	-	1.1.1.53	ko:K00038	ko00140,ko01100,map00140,map01100	-	R04831,R04834,R04844,R04847	RC00139,RC01219,RC01220	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
k59_1407776_1	42565.FP66_12480	2.71e-10	65.1	COG2968@1|root,COG2968@2|Bacteria,1NF31@1224|Proteobacteria,1RW7Y@1236|Gammaproteobacteria,1XMUM@135619|Oceanospirillales	135619|Oceanospirillales	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
k59_1407776_2	477228.YO5_03687	1.01e-59	189.0	COG0386@1|root,COG0386@2|Bacteria,1PY6H@1224|Proteobacteria,1SNWD@1236|Gammaproteobacteria,1Z050@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	O	Belongs to the glutathione peroxidase family	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
k59_352210_1	452637.Oter_0749	5.58e-33	124.0	COG0839@1|root,COG0839@2|Bacteria	2|Bacteria	C	Belongs to the complex I subunit 6 family	ndhG	-	1.6.5.3	ko:K00339,ko:K05578	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_524431_1	1033802.SSPSH_003246	4.46e-13	67.8	COG4970@1|root,COG4970@2|Bacteria,1N7RS@1224|Proteobacteria,1SCFB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	COG4970 Tfp pilus assembly protein FimT	-	-	-	ko:K08084	-	-	-	-	ko00000,ko02044	3.A.15.2	-	-	GspH,N_methyl
k59_352211_1	1121943.KB899996_gene601	5.35e-164	486.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1XH7W@135619|Oceanospirillales	135619|Oceanospirillales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_524434_2	1123247.AUIJ01000057_gene2775	2.04e-65	209.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_1641483_1	749414.SBI_01868	1.56e-79	253.0	COG3507@1|root,COG3507@2|Bacteria,2GIW3@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	Glyco_hydro_43
k59_583978_1	1279017.AQYJ01000027_gene1620	6e-98	293.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,464R4@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT	pilT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_810803_1	177437.HRM2_21630	4.57e-46	164.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MJ4K@213118|Desulfobacterales	28221|Deltaproteobacteria	CK	PFAM Acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
k59_1815005_1	641491.DND132_2252	4.32e-45	166.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2M7S1@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_1467050_1	1232437.KL662073_gene1746	6.48e-42	149.0	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,42QGY@68525|delta/epsilon subdivisions,2WKHR@28221|Deltaproteobacteria,2MJDT@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1467054_1	411490.ANACAC_03775	0.000576	41.6	COG0315@1|root,COG0315@2|Bacteria,1V3J4@1239|Firmicutes,24H9F@186801|Clostridia	186801|Clostridia	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
k59_1467054_2	1408473.JHXO01000010_gene3615	4.2e-56	185.0	COG0521@1|root,COG2258@1|root,COG0521@2|Bacteria,COG2258@2|Bacteria,4PNHR@976|Bacteroidetes	976|Bacteroidetes	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth,MoaC
k59_1815041_1	1336233.JAEH01000002_gene1372	8.51e-29	119.0	COG1922@1|root,COG2148@1|root,COG1922@2|Bacteria,COG2148@2|Bacteria,1N1HD@1224|Proteobacteria,1RP6P@1236|Gammaproteobacteria,2QAQA@267890|Shewanellaceae	1236|Gammaproteobacteria	M	TIGRFAM glycosyl transferase, WecB TagA CpsF family	gumM	-	2.4.1.187	ko:K05946,ko:K13660	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Bac_transf,Glyco_tran_WecB
k59_1584479_1	1123401.JHYQ01000002_gene2785	2.89e-63	207.0	COG0547@1|root,COG0547@2|Bacteria,1PI4H@1224|Proteobacteria,1T9UI@1236|Gammaproteobacteria,4623U@72273|Thiotrichales	72273|Thiotrichales	E	PFAM Glycosyl transferase family, a b domain	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_trans_3N,Glycos_transf_3
k59_1407831_1	1249627.D779_3075	3.6e-103	310.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1WW2C@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_524494_1	257313.BP1497	3.88e-123	369.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2VHFD@28216|Betaproteobacteria,3T1Z9@506|Alcaligenaceae	28216|Betaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_469012_1	1385517.N800_02080	6.38e-07	55.5	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,1RNH2@1236|Gammaproteobacteria,1X4C7@135614|Xanthomonadales	135614|Xanthomonadales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	phbB	-	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
k59_527811_1	292415.Tbd_2397	4.81e-56	197.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,1KSFJ@119069|Hydrogenophilales	119069|Hydrogenophilales	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1172985_1	693444.D782_4136	4.2e-61	202.0	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,1RNK4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Type I secretion membrane fusion protein, HlyD	lssD	-	-	ko:K02022,ko:K12542	-	M00330	-	-	ko00000,ko00002,ko02000,ko02044	3.A.1.109.4,8.A.1	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
k59_813714_1	338969.Rfer_2160	2.68e-40	154.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria,4ABG1@80864|Comamonadaceae	28216|Betaproteobacteria	G	SMART alpha amylase catalytic sub domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_527875_2	1049564.TevJSym_ap00270	2.88e-88	265.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1J5GV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm2	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_813744_1	333138.LQ50_20855	8e-29	116.0	COG1638@1|root,COG1638@2|Bacteria,1UY2X@1239|Firmicutes,4IIPY@91061|Bacilli,1ZGUX@1386|Bacillus	91061|Bacilli	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_813753_2	13035.Dacsa_2920	3.79e-39	147.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1G02W@1117|Cyanobacteria	1117|Cyanobacteria	EQ	N-methylhydantoinase B acetone carboxylase alpha subunit	oplaH	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_527902_2	1187851.A33M_4140	5e-44	147.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U952@28211|Alphaproteobacteria,3FE86@34008|Rhodovulum	28211|Alphaproteobacteria	K	Nitrogen regulatory protein P-II	glnK	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
k59_527925_1	977880.RALTA_A2720	4.12e-115	357.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,1K0RR@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1818442_1	1396141.BATP01000020_gene43	2.84e-25	108.0	COG3533@1|root,COG3533@2|Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,Glyco_hydro_127
k59_813890_1	1191523.MROS_2798	9.17e-41	153.0	COG0574@1|root,COG0574@2|Bacteria	2|Bacteria	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_2,PPDK_N,Response_reg
k59_1818447_1	1168065.DOK_05905	1.34e-41	139.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,1S5XT@1236|Gammaproteobacteria,1J668@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_1818447_2	765913.ThidrDRAFT_1743	4.67e-28	107.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,1WVYC@135613|Chromatiales	135613|Chromatiales	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_528041_1	765912.Thimo_3132	9.8e-18	86.7	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1WWY6@135613|Chromatiales	135613|Chromatiales	U	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
k59_528116_1	316067.Geob_3027	7.1e-93	275.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,43SE2@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Ferritin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
k59_528174_1	1120970.AUBZ01000019_gene3563	6.48e-179	509.0	COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RPUP@1236|Gammaproteobacteria,465AR@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components	nrtC	-	-	ko:K15576	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	NMT1_2
k59_1173355_1	1123073.KB899242_gene1451	4.94e-78	250.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RPIW@1236|Gammaproteobacteria,1X5RA@135614|Xanthomonadales	135614|Xanthomonadales	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
k59_1173366_1	1123367.C666_01510	2.6e-101	313.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2VKAN@28216|Betaproteobacteria,2KVQH@206389|Rhodocyclales	206389|Rhodocyclales	I	Acetyl-coenzyme A synthetase N-terminus	acsA	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1818618_1	1255043.TVNIR_0857	2.6e-48	157.0	COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,1SD0S@1236|Gammaproteobacteria,1WY53@135613|Chromatiales	135613|Chromatiales	P	Belongs to the DsrF TusC family	dsrF	-	-	ko:K07236	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DrsE
k59_1818618_2	1249627.D779_2147	3.2e-19	80.9	COG2168@1|root,COG2168@2|Bacteria,1NGF3@1224|Proteobacteria,1SGPI@1236|Gammaproteobacteria,1WYI4@135613|Chromatiales	135613|Chromatiales	P	sulfur relay protein TusB DsrH	-	-	-	ko:K07237	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DsrH
k59_1173442_1	1410620.SHLA_41c000300	1.83e-63	206.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,4BA6V@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_814189_2	378806.STAUR_4432	7.47e-06	50.8	COG1595@1|root,COG1595@2|Bacteria,1N413@1224|Proteobacteria,42SGS@68525|delta/epsilon subdivisions,2WPQ9@28221|Deltaproteobacteria,2YZMY@29|Myxococcales	28221|Deltaproteobacteria	K	Helix-turn-helix domain	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_814198_1	243233.MCA2445	8.96e-05	42.7	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,1XEYJ@135618|Methylococcales	135618|Methylococcales	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
k59_814198_2	1215092.PA6_018_01210	1.55e-61	204.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1YE9B@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	ic_1306.c0216	Hexapep,Hexapep_2,LpxD
k59_1818743_1	913865.DOT_5140	7.33e-57	182.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	tpm	-	2.1.1.67	ko:K00569	ko00983,map00983	-	R08236,R08239,R08246	RC00003,RC00980,RC02277	ko00000,ko00001,ko01000	-	-	-	Methyltransf_25,TPMT
k59_814229_1	1137799.GZ78_12880	5.03e-52	177.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1XHXR@135619|Oceanospirillales	135619|Oceanospirillales	Q	TRAP-type mannitol chloroaromatic compound transport system, large permease component	gtrB	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_814229_2	765912.Thimo_0632	1.27e-49	164.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1S5Y0@1236|Gammaproteobacteria,1WXYX@135613|Chromatiales	135613|Chromatiales	Q	TRAP-type mannitol chloroaromatic compound transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_814239_2	471853.Bcav_2780	8.91e-27	110.0	COG0477@1|root,COG2814@2|Bacteria,2GJK6@201174|Actinobacteria	201174|Actinobacteria	EGP	Drug resistance transporter, bcr cfla subfamily	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_814257_1	1095767.CAHD01000136_gene2293	7.97e-48	172.0	COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,2GJ5U@201174|Actinobacteria,4F0GJ@85016|Cellulomonadaceae	201174|Actinobacteria	C	belongs to the CobB CobQ family	pta	GO:0005575,GO:0005576	2.3.1.8	ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,DRTGG,PTA_PTB
k59_1173612_1	765912.Thimo_2867	3.26e-71	239.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1818802_1	319225.Plut_1831	1.47e-25	105.0	COG1484@1|root,COG1484@2|Bacteria	2|Bacteria	L	DNA-dependent DNA replication	-	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21
k59_814269_1	1429046.RR21198_5822	6.72e-81	248.0	COG0177@1|root,COG0177@2|Bacteria,2GNE5@201174|Actinobacteria,4FUKC@85025|Nocardiaceae	201174|Actinobacteria	L	HhH-GPD superfamily base excision DNA repair protein	-	-	-	-	-	-	-	-	-	-	-	-	HhH-GPD
k59_814289_2	582744.Msip34_1299	3.31e-59	195.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VJ00@28216|Betaproteobacteria,2KP5H@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_1173692_1	95619.PM1_0213155	3.17e-45	160.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_1818871_1	1485544.JQKP01000003_gene103	2.03e-59	205.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2VKDZ@28216|Betaproteobacteria,44VIM@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_814348_2	888056.HMPREF9062_0379	1.2e-38	142.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,4D3NY@85005|Actinomycetales	201174|Actinobacteria	KLT	Kinase domain protein	pknA	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_1818933_1	582899.Hden_2459	1.44e-55	183.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,3N6K9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NADPH quinone oxidoreductase	MA20_18095	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1173836_1	1304865.JAGF01000001_gene1025	1.16e-84	265.0	COG0477@1|root,COG2814@2|Bacteria,2GKHG@201174|Actinobacteria,4F2AT@85016|Cellulomonadaceae	201174|Actinobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_1173921_1	1123368.AUIS01000003_gene1844	1.91e-24	97.4	2C7AT@1|root,338A4@2|Bacteria,1NF74@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1173921_2	1279019.ARQK01000029_gene2402	1.98e-11	66.6	COG0526@1|root,COG0526@2|Bacteria,1NAUV@1224|Proteobacteria,1SF3P@1236|Gammaproteobacteria,1WYJM@135613|Chromatiales	135613|Chromatiales	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_1173933_1	638301.HMPREF0444_0427	2.01e-14	75.9	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,4H9KA@91061|Bacilli,27F9S@186828|Carnobacteriaceae	91061|Bacilli	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_1819076_1	743718.Isova_0695	3.06e-99	298.0	COG1072@1|root,COG1072@2|Bacteria,2GIRR@201174|Actinobacteria,4F34I@85017|Promicromonosporaceae	201174|Actinobacteria	H	Phosphoribulokinase / Uridine kinase family	coaA	GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.33	ko:K00867	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
k59_814574_1	713586.KB900536_gene819	9.13e-91	281.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WW29@135613|Chromatiales	135613|Chromatiales	S	PFAM Uncharacterised protein family UPF0027	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_1649065_2	269482.Bcep1808_3255	1.16e-27	115.0	COG4974@1|root,COG4974@2|Bacteria,1NY1A@1224|Proteobacteria,2WGQ1@28216|Betaproteobacteria,1KIMK@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_1119818_1	1117315.AHCA01000001_gene2200	1.14e-34	129.0	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,1RNMF@1236|Gammaproteobacteria,2Q0Z9@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1722)	ybgA	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
k59_1473081_1	1298867.AUES01000051_gene4511	3.02e-24	106.0	COG0771@1|root,COG2931@1|root,COG4625@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K2H3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,HemolysinCabind
k59_1531189_1	671143.DAMO_0743	1.1e-23	105.0	COG0642@1|root,COG0784@1|root,COG3829@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,2NNXM@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	barA	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3
k59_1649067_1	589865.DaAHT2_0484	2.67e-57	197.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42N7X@68525|delta/epsilon subdivisions,2WMM9@28221|Deltaproteobacteria,2MMU3@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_298829_1	1125863.JAFN01000001_gene1050	8.81e-45	162.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42RX5@68525|delta/epsilon subdivisions,2WNRV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_7182_1	390235.PputW619_4399	1.31e-19	94.0	COG1105@1|root,COG1105@2|Bacteria,1MVNW@1224|Proteobacteria,1RP6K@1236|Gammaproteobacteria,1YV9K@136845|Pseudomonas putida group	1236|Gammaproteobacteria	H	belongs to the carbohydrate kinase PfkB family	fruK	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0008662,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019318,GO:0019320,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575	2.7.1.11,2.7.1.56	ko:K00882,ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R02071,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2168,iAPECO1_1312.APECO1_4386,iB21_1397.B21_02056,iEC042_1314.EC042_2401,iEC55989_1330.EC55989_2421,iECABU_c1320.ECABU_c24990,iECBD_1354.ECBD_1490,iECB_1328.ECB_02097,iECDH10B_1368.ECDH10B_2325,iECDH1ME8569_1439.ECDH1ME8569_2104,iECD_1391.ECD_02097,iECED1_1282.ECED1_2616,iECH74115_1262.ECH74115_3304,iECIAI1_1343.ECIAI1_2248,iECIAI39_1322.ECIAI39_2308,iECNA114_1301.ECNA114_2259,iECO103_1326.ECO103_2643,iECO111_1330.ECO111_2886,iECO26_1355.ECO26_3080,iECOK1_1307.ECOK1_2400,iECP_1309.ECP_2208,iECS88_1305.ECS88_2316,iECSE_1348.ECSE_2436,iECSF_1327.ECSF_2049,iECSP_1301.ECSP_3046,iECUMN_1333.ECUMN_2504,iECW_1372.ECW_m2369,iECs_1301.ECs3060,iEKO11_1354.EKO11_1586,iETEC_1333.ETEC_2303,iEcDH1_1363.EcDH1_1490,iEcHS_1320.EcHS_A2305,iEcSMS35_1347.EcSMS35_2315,iEcolC_1368.EcolC_1480,iG2583_1286.G2583_2711,iJO1366.b2168,iJR904.b2168,iLF82_1304.LF82_0744,iNRG857_1313.NRG857_11005,iPC815.YPO1299,iSBO_1134.SBO_2156,iSDY_1059.SDY_2316,iSFV_1184.SFV_2243,iSF_1195.SF2253,iSFxv_1172.SFxv_2486,iS_1188.S2382,iUMN146_1321.UM146_05955,iUMNK88_1353.UMNK88_2713,iUTI89_1310.UTI89_C2443,iWFL_1372.ECW_m2369,iY75_1357.Y75_RS11345,iZ_1308.Z3426,ic_1306.c2703	PfkB
k59_7182_2	1240349.ANGC01000053_gene4151	7.91e-55	184.0	COG1030@1|root,COG1030@2|Bacteria,2IIZ2@201174|Actinobacteria,4G0P6@85025|Nocardiaceae	201174|Actinobacteria	-	-	wcoO	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
k59_947113_1	1328313.DS2_03770	3.26e-10	68.2	2AEF4@1|root,314A4@2|Bacteria,1N9MZ@1224|Proteobacteria,1SWDK@1236|Gammaproteobacteria,46BXP@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_592253_1	313624.NSP_28730	3.13e-15	76.6	COG3437@1|root,COG3437@2|Bacteria,1G2ZH@1117|Cyanobacteria,1HK6V@1161|Nostocales	1117|Cyanobacteria	T	Response regulator receiver domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
k59_1179135_1	497964.CfE428DRAFT_6151	3.66e-100	314.0	COG0272@1|root,COG0272@2|Bacteria,46TMK@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_1473098_1	1278309.KB907102_gene169	7.67e-124	367.0	COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RP1C@1236|Gammaproteobacteria,1XIUD@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the glutamate synthase family	-	-	2.1.1.21	ko:K22083	ko00680,ko01120,map00680,map01120	-	R01586	RC00554	ko00000,ko00001,ko01000	-	-	-	Glu_synthase,zf-CDGSH
k59_122523_1	1232410.KI421421_gene3489	2.46e-49	174.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,42MY5@68525|delta/epsilon subdivisions,2WKST@28221|Deltaproteobacteria,43UAH@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Peptidase dimerisation domain	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_474763_1	1439940.BAY1663_00402	3.72e-20	90.9	COG0111@1|root,COG0111@2|Bacteria,1N5TD@1224|Proteobacteria,1RMFW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate	pdxB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0033711,GO:0034641,GO:0036001,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.1.1.290	ko:K03473	ko00750,ko01100,map00750,map01100	M00124	R04210	RC00084	ko00000,ko00001,ko00002,ko01000	-	-	iZ_1308.Z3582	2-Hacid_dh,2-Hacid_dh_C,DUF3410
k59_1414192_1	96561.Dole_1175	1.77e-90	278.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2WITH@28221|Deltaproteobacteria,2MHR7@213118|Desulfobacterales	28221|Deltaproteobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	algC	-	5.4.2.2,5.4.2.8	ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1827481_1	498211.CJA_3523	5.91e-84	261.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1FFUM@10|Cellvibrio	1236|Gammaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iJN746.PP_5285,iSBO_1134.SBO_3641	DFP,Flavoprotein
k59_1827481_2	713587.THITH_15670	2.62e-94	280.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,1WXFP@135613|Chromatiales	135613|Chromatiales	L	Belongs to the UPF0758 family	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
k59_1649086_1	314278.NB231_03807	2.86e-07	50.4	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,1RN32@1236|Gammaproteobacteria,1WWN9@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
k59_1649086_2	2340.JV46_20350	5.58e-64	205.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1J5UV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_888245_1	768671.ThimaDRAFT_2863	3.24e-87	276.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1WXQ0@135613|Chromatiales	135613|Chromatiales	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_66455_1	572477.Alvin_1047	4.21e-99	300.0	COG1449@1|root,COG1449@2|Bacteria,1R5KI@1224|Proteobacteria,1S0ID@1236|Gammaproteobacteria,1WXJ4@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_650981_2	472759.Nhal_0725	5.98e-44	155.0	COG0460@1|root,COG2844@1|root,COG0460@2|Bacteria,COG2844@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1WWHB@135613|Chromatiales	135613|Chromatiales	E	homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
k59_1531213_1	1122927.KB895414_gene5126	9.29e-69	221.0	COG0604@1|root,COG0604@2|Bacteria,1TQ0M@1239|Firmicutes,4HA8M@91061|Bacilli,26QXS@186822|Paenibacillaceae	91061|Bacilli	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
k59_592274_1	1040989.AWZU01000008_gene3776	2.27e-36	136.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2U0D0@28211|Alphaproteobacteria,3JURI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Glucose-6-phosphate dehydrogenase, NAD binding domain	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_592274_2	983917.RGE_18150	4.92e-06	48.5	COG1195@1|root,COG3593@1|root,COG1195@2|Bacteria,COG3593@2|Bacteria,1MXF2@1224|Proteobacteria,2VJNZ@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Protein of unknown function (DUF2813)	-	-	-	ko:K07459	-	-	-	-	ko00000	-	-	-	AAA_15
k59_1238199_1	765698.Mesci_0854	1.22e-61	201.0	COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2TQXW@28211|Alphaproteobacteria,43I1W@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	TIGRFAM polyhydroxyalkanoate depolymerase, intracellular	phaZ	-	3.1.1.75	ko:K05973	ko00650,map00650	-	R05118	-	ko00000,ko00001,ko01000	-	-	-	PHB_depo_C
k59_1299383_1	717785.HYPMC_2980	5.6e-21	92.0	COG3719@1|root,COG3719@2|Bacteria,1PTUN@1224|Proteobacteria,2TQUU@28211|Alphaproteobacteria,3N8MD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the RNase T2 family	rns	-	3.1.27.1,3.1.27.6	ko:K01166,ko:K01169	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_T2
k59_1473129_1	1463879.JOHP01000037_gene6933	3.47e-163	466.0	COG3547@1|root,COG3547@2|Bacteria,2GNQB@201174|Actinobacteria	201174|Actinobacteria	L	transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_709609_1	765912.Thimo_2473	5.08e-99	305.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria,1WXTE@135613|Chromatiales	135613|Chromatiales	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_709609_2	1000565.METUNv1_03569	1.39e-16	78.2	COG2995@1|root,COG2995@2|Bacteria,1RAQ9@1224|Proteobacteria,2VQ5G@28216|Betaproteobacteria,2KWRN@206389|Rhodocyclales	206389|Rhodocyclales	S	Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_888271_1	743721.Psesu_1592	8.83e-108	322.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,1RMFI@1236|Gammaproteobacteria,1X3K9@135614|Xanthomonadales	135614|Xanthomonadales	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
k59_888271_2	443143.GM18_3176	8.34e-16	80.5	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,42PSZ@68525|delta/epsilon subdivisions,2WMBH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
k59_66482_1	196162.Noca_3753	1.85e-86	267.0	COG2265@1|root,COG2265@2|Bacteria,2GP90@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumB	-	2.1.1.189	ko:K03212	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	tRNA_U5-meth_tr
k59_181274_1	269800.Tfu_0092	2.09e-183	516.0	COG0039@1|root,COG0039@2|Bacteria,2GJHS@201174|Actinobacteria,4EGHB@85012|Streptosporangiales	201174|Actinobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0030312,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0072524,GO:1901360,GO:1901564	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
k59_181274_2	298654.FraEuI1c_0536	4.57e-27	107.0	2F0VE@1|root,33TX8@2|Bacteria,2INWW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
k59_7260_1	935839.JAGJ01000018_gene2338	2.36e-117	345.0	COG1905@1|root,COG1905@2|Bacteria,2GKG0@201174|Actinobacteria,4F3Y3@85017|Promicromonosporaceae	201174|Actinobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_1119851_1	1158762.KB898054_gene53	5.59e-32	124.0	COG1434@1|root,COG1434@2|Bacteria,1MVW8@1224|Proteobacteria,1S92A@1236|Gammaproteobacteria,1WZ2D@135613|Chromatiales	135613|Chromatiales	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
k59_1119851_2	765911.Thivi_1974	4.03e-20	85.9	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,1S23A@1236|Gammaproteobacteria,1WWYC@135613|Chromatiales	135613|Chromatiales	JM	PFAM Nucleotidyl transferase	-	-	2.7.7.99	ko:K00992	ko00520,ko01100,map00520,map01100	-	R11025	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
k59_359961_1	697282.Mettu_0394	4.24e-35	134.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1XE20@135618|Methylococcales	135618|Methylococcales	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_359961_2	335543.Sfum_1470	2.57e-38	143.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42N22@68525|delta/epsilon subdivisions,2WIMH@28221|Deltaproteobacteria,2MQBA@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_181280_1	367299.JOEE01000001_gene1516	1.13e-72	232.0	COG0402@1|root,COG0402@2|Bacteria,2GM63@201174|Actinobacteria,4FF0Y@85021|Intrasporangiaceae	201174|Actinobacteria	F	Amidohydrolase family	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_1238223_1	935837.JAEK01000008_gene3445	3.91e-36	139.0	COG5520@1|root,COG5520@2|Bacteria,1TS99@1239|Firmicutes,4HEUA@91061|Bacilli,1ZF3X@1386|Bacillus	91061|Bacilli	M	Belongs to the glycosyl hydrolase 30 family	-	-	3.2.1.136	ko:K15924	-	-	-	-	ko00000,ko01000	-	GH5	-	CBM_6,Glyco_hydr_30_2
k59_1531232_1	1123073.KB899244_gene406	7.57e-91	285.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1S1HS@1236|Gammaproteobacteria,1X48P@135614|Xanthomonadales	135614|Xanthomonadales	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
k59_651013_1	1244869.H261_05829	2.03e-05	46.6	COG4314@1|root,COG4314@2|Bacteria,1N3G0@1224|Proteobacteria	1224|Proteobacteria	C	lipoprotein involved in nitrous oxide reduction	-	-	-	ko:K19342	-	-	-	-	ko00000	-	-	-	NosL
k59_651013_2	768671.ThimaDRAFT_0909	8.65e-133	385.0	COG1131@1|root,COG1131@2|Bacteria,1R3XF@1224|Proteobacteria,1S0MM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	abc transporter atp-binding protein	nodI	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_359976_1	187272.Mlg_1944	6.07e-152	449.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1WW27@135613|Chromatiales	135613|Chromatiales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_415888_1	395964.KE386496_gene1861	5.91e-70	228.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,3N9UD@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_66507_1	909663.KI867150_gene2888	2.04e-127	385.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,42P3J@68525|delta/epsilon subdivisions,2WKFS@28221|Deltaproteobacteria,2MQ9F@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_241212_1	90813.JQMT01000001_gene1659	3.16e-99	299.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,4602E@72273|Thiotrichales	72273|Thiotrichales	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
k59_826768_2	1162668.LFE_1814	1.52e-28	117.0	COG0364@1|root,COG0364@2|Bacteria,3J0XD@40117|Nitrospirae	40117|Nitrospirae	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_7300_2	1249627.D779_0637	1.25e-06	50.4	COG1366@1|root,COG1366@2|Bacteria,1PTSR@1224|Proteobacteria,1TKDX@1236|Gammaproteobacteria,1X230@135613|Chromatiales	135613|Chromatiales	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS
k59_7300_3	1410666.JHXG01000009_gene469	5.07e-05	45.8	COG2172@1|root,COG2208@1|root,COG2770@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,COG2770@2|Bacteria,4NI98@976|Bacteroidetes,2FPEX@200643|Bacteroidia	976|Bacteroidetes	KT	SpoIIE domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,Response_reg,SpoIIE,dCache_1
k59_1179192_1	1120985.AUMI01000011_gene519	2.7e-99	300.0	COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,4H2IF@909932|Negativicutes	909932|Negativicutes	E	diaminopimelate decarboxylase	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_888307_1	138119.DSY0514	1.81e-24	105.0	COG2223@1|root,COG2223@2|Bacteria,1TPR9@1239|Firmicutes,2483N@186801|Clostridia,260AH@186807|Peptococcaceae	186801|Clostridia	P	PFAM Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
k59_241229_2	485915.Dret_0477	1.38e-13	71.2	COG0834@1|root,COG0834@2|Bacteria,1MWDK@1224|Proteobacteria,42NVT@68525|delta/epsilon subdivisions,2WJ9C@28221|Deltaproteobacteria,2M9NJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	ET	extracellular solute-binding protein, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_1473185_1	1117943.SFHH103_02842	1.35e-38	141.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2TRSV@28211|Alphaproteobacteria,4BBRM@82115|Rhizobiaceae	28211|Alphaproteobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
k59_415902_1	857087.Metme_1660	2.92e-72	224.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1XE6M@135618|Methylococcales	135618|Methylococcales	S	PFAM Polyphosphate kinase 2	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_947224_1	765912.Thimo_2449	4.58e-52	171.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,1WWJ2@135613|Chromatiales	135613|Chromatiales	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
k59_947224_2	768671.ThimaDRAFT_2431	2.35e-114	341.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria,1WXHA@135613|Chromatiales	135613|Chromatiales	S	Peptidogalycan biosysnthesis/recognition	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
k59_888324_1	435908.IDSA_03805	2.08e-37	144.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,2QF0P@267893|Idiomarinaceae	1236|Gammaproteobacteria	P	Putative metal-binding domain of cation transport ATPase	ccoI	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_1238260_1	321332.CYB_1948	3.71e-13	70.5	COG0583@1|root,COG0583@2|Bacteria,1G0RE@1117|Cyanobacteria,1GYKW@1129|Synechococcus	1117|Cyanobacteria	K	LysR family	cmpR	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_888326_1	926550.CLDAP_34850	1.8e-94	281.0	COG0647@1|root,COG0647@2|Bacteria,2G60W@200795|Chloroflexi	200795|Chloroflexi	G	COGs COG0647 sugar phosphatase of the HAD superfamily	-	-	-	ko:K02566	-	-	-	-	ko00000	-	-	-	Hydrolase_6,Hydrolase_like
k59_592333_1	187272.Mlg_2225	9.45e-118	346.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1WWFJ@135613|Chromatiales	135613|Chromatiales	M	Arabinose 5-phosphate isomerase	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
k59_1765991_1	631362.Thi970DRAFT_03334	9.29e-79	250.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1WWXH@135613|Chromatiales	135613|Chromatiales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1119887_2	768671.ThimaDRAFT_0488	2.47e-13	64.3	COG4710@1|root,COG4710@2|Bacteria,1QDBM@1224|Proteobacteria,1T99M@1236|Gammaproteobacteria,1X1D9@135613|Chromatiales	135613|Chromatiales	S	Ribbon-helix-helix protein, copG family	-	-	-	ko:K18918	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	RHH_1
k59_122591_1	1286093.C266_23783	1.87e-72	223.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,2VQ1I@28216|Betaproteobacteria,1K2BA@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
k59_122591_2	1123368.AUIS01000029_gene1282	6.23e-154	445.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,1RQEI@1236|Gammaproteobacteria,2NBXD@225057|Acidithiobacillales	225057|Acidithiobacillales	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
k59_122591_3	1122194.AUHU01000006_gene438	6.95e-47	161.0	COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,1RYFC@1236|Gammaproteobacteria,4666X@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	HPP family	-	-	-	ko:K07168	-	-	-	-	ko00000	-	-	-	HPP
k59_1589769_1	266264.Rmet_5087	1.05e-52	179.0	COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2VJ0J@28216|Betaproteobacteria,1K48A@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
k59_241268_1	243090.RB168	1.83e-26	106.0	COG3464@1|root,COG3464@2|Bacteria,2J31D@203682|Planctomycetes	203682|Planctomycetes	L	zinc-finger of transposase IS204/IS1001/IS1096/IS1165	-	-	-	-	-	-	-	-	-	-	-	-	zf-ISL3
k59_1300521_1	1155714.KB891988_gene1873	5.2e-20	92.4	COG1376@1|root,COG1376@2|Bacteria,2GJBA@201174|Actinobacteria	201174|Actinobacteria	L	ErfK YbiS YcfS YnhG family protein	lppS	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0006022,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0009273,GO:0009987,GO:0016787,GO:0017171,GO:0019538,GO:0030203,GO:0030312,GO:0042546,GO:0043170,GO:0044085,GO:0044238,GO:0044464,GO:0070008,GO:0070011,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0140096,GO:1901135,GO:1901564	-	-	-	-	-	-	-	-	-	-	YkuD
k59_182090_1	28258.KP05_06725	8.97e-57	184.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1S5Y0@1236|Gammaproteobacteria,1XK0E@135619|Oceanospirillales	135619|Oceanospirillales	Q	TRAP-type mannitol chloroaromatic compound transport system, small permease component	gtrA	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_182090_2	396588.Tgr7_0085	7.9e-29	107.0	2C1YJ@1|root,32ZXK@2|Bacteria,1N98H@1224|Proteobacteria,1SD8N@1236|Gammaproteobacteria,1WZ2H@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF2782)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2782
k59_182090_3	1163617.SCD_n00045	2.92e-25	100.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2VK4I@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the LOG family	yvdD_2	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_1590459_1	396588.Tgr7_2153	3.59e-211	595.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1WWU2@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1590459_2	1122194.AUHU01000018_gene3462	5.53e-24	101.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,1RPBB@1236|Gammaproteobacteria,4645F@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
k59_948325_1	498211.CJA_3183	2.89e-17	77.4	COG5302@1|root,COG5302@2|Bacteria,1PU5I@1224|Proteobacteria,1TB7N@1236|Gammaproteobacteria,1FIGZ@10|Cellvibrio	1236|Gammaproteobacteria	S	Post-segregation antitoxin CcdA	ccdA	-	-	ko:K19164	-	-	-	-	ko00000,ko02048	-	-	-	CcdA
k59_948325_2	1499686.BN1079_00795	5.53e-30	109.0	2DNNV@1|root,32YCB@2|Bacteria,1N7IN@1224|Proteobacteria	1224|Proteobacteria	S	Plasmid maintenance protein CcdB	ccdB	-	-	ko:K19163	-	-	-	-	ko00000,ko02048	-	-	-	CcdB
k59_1356041_1	765912.Thimo_1248	2.65e-78	248.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1WWDN@135613|Chromatiales	135613|Chromatiales	S	PFAM Peptidoglycan-binding lysin domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_252147_1	318167.Sfri_1814	8.81e-79	247.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,2QAVB@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP
k59_187354_1	1521187.JPIM01000019_gene378	1.36e-10	57.4	COG2343@1|root,COG2343@2|Bacteria,2G79F@200795|Chloroflexi,377I0@32061|Chloroflexia	32061|Chloroflexia	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
k59_187354_2	1043493.BBLU01000014_gene1284	2.94e-126	364.0	COG0655@1|root,COG0655@2|Bacteria,2GKTM@201174|Actinobacteria	201174|Actinobacteria	S	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
k59_252150_1	2340.JV46_13570	5.86e-55	184.0	2B5QC@1|root,31YJX@2|Bacteria,1RIBA@1224|Proteobacteria,1SPMT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
k59_539194_1	1249627.D779_3492	1.99e-68	222.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RYB4@1236|Gammaproteobacteria,1WVUT@135613|Chromatiales	135613|Chromatiales	CP	PFAM NADH Ubiquinone plastoquinone	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_1835576_2	1121405.dsmv_0342	3.85e-72	232.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42M1W@68525|delta/epsilon subdivisions,2WK53@28221|Deltaproteobacteria,2MIJV@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1712794_1	1122933.JNIY01000004_gene2448	1.43e-84	262.0	COG1653@1|root,COG1653@2|Bacteria,2GJIP@201174|Actinobacteria,4F1V3@85016|Cellulomonadaceae	201174|Actinobacteria	G	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K10240	ko02010,map02010	M00206	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.23	-	-	SBP_bac_8
k59_715622_1	913325.N799_14220	2.4e-89	277.0	COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1RPVU@1236|Gammaproteobacteria,1X59X@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	creC	-	2.7.13.3	ko:K07641	ko02020,map02020	M00449	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_1246338_1	395493.BegalDRAFT_1376	2.01e-65	214.0	COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,460I1@72273|Thiotrichales	72273|Thiotrichales	D	Part of the ABC transporter FtsEX involved in cellular division	-	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
k59_1246338_2	523791.Kkor_2567	5.1e-103	305.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,1XH6V@135619|Oceanospirillales	135619|Oceanospirillales	D	cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_1124695_2	439235.Dalk_2654	1.59e-10	61.6	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2MMMT@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HTH_8,Sigma54_activat
k59_18511_1	1123392.AQWL01000008_gene1233	1.08e-20	86.3	COG3501@1|root,COG3501@2|Bacteria,1R540@1224|Proteobacteria,2VS00@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Baseplate assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_18511_2	1234364.AMSF01000015_gene3074	5.91e-153	443.0	COG3500@1|root,COG3500@2|Bacteria,1Q2U5@1224|Proteobacteria,1RQ3S@1236|Gammaproteobacteria,1X67K@135614|Xanthomonadales	135614|Xanthomonadales	S	Late control gene D protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_18511_3	227882.SAV_389	6.08e-22	90.5	COG1652@1|root,COG1652@2|Bacteria,2IMSS@201174|Actinobacteria	201174|Actinobacteria	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_18511_4	1123392.AQWL01000008_gene1230	2.48e-33	121.0	2CI52@1|root,2ZC5H@2|Bacteria,1R9WI@1224|Proteobacteria,2VQZX@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_832816_1	1463864.JOGO01000077_gene3353	1.15e-100	305.0	COG0673@1|root,COG0673@2|Bacteria,2GN2Z@201174|Actinobacteria	201174|Actinobacteria	S	oxidoreductase	ydgJ	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_367975_1	335543.Sfum_3911	2.47e-79	263.0	COG0458@1|root,COG0458@2|Bacteria,1NPMZ@1224|Proteobacteria,42NF3@68525|delta/epsilon subdivisions,2WM4C@28221|Deltaproteobacteria,2MQ8X@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthetase large chain, oligomerisation	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0661	CPSase_L_D2,CPSase_L_D3,MGS
k59_1536691_1	1095769.CAHF01000003_gene992	2.26e-59	192.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2VI2H@28216|Betaproteobacteria,472WE@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_1420428_1	1248916.ANFY01000005_gene2858	5.33e-31	125.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,2K6JI@204457|Sphingomonadales	204457|Sphingomonadales	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2,TPR_8,Trans_reg_C
k59_480396_1	314282.PCNPT3_02325	3.21e-41	149.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,2QHDH@267894|Psychromonadaceae	1236|Gammaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	fieF	GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005385,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006829,GO:0006873,GO:0006875,GO:0006876,GO:0006882,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015086,GO:0015093,GO:0015291,GO:0015318,GO:0015341,GO:0015562,GO:0015684,GO:0015691,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0030003,GO:0034220,GO:0034755,GO:0042592,GO:0042802,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055069,GO:0055073,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070574,GO:0070838,GO:0071577,GO:0071944,GO:0072503,GO:0072507,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:1903874	-	ko:K13283	-	-	-	-	ko00000,ko02000	2.A.4.7.1	-	-	Cation_efflux,ZT_dimer
k59_1307364_1	391626.OAN307_c01950	4.61e-07	59.3	COG0845@1|root,COG0845@2|Bacteria,1NKWA@1224|Proteobacteria,2TQXT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Efflux transporter, RND family, MFP subunit	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,OEP
k59_1536694_1	998674.ATTE01000001_gene4264	6.68e-58	198.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,460G2@72273|Thiotrichales	72273|Thiotrichales	J	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
k59_772885_1	743718.Isova_0611	6.64e-125	369.0	COG0493@1|root,COG0493@2|Bacteria,2GJ4A@201174|Actinobacteria,4F3BP@85017|Promicromonosporaceae	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	fprA	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	Pyr_redox_2
k59_75515_2	545264.KB898746_gene687	3.67e-52	171.0	COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,1S302@1236|Gammaproteobacteria,1WX78@135613|Chromatiales	135613|Chromatiales	C	Protein of unknown function (DUF3501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
k59_956275_1	207559.Dde_3424	1.73e-191	558.0	COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,42M86@68525|delta/epsilon subdivisions,2WIT1@28221|Deltaproteobacteria,2M8F1@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Subunit R is required for both nuclease and ATPase activities, but not for modification	hsdR	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
k59_598299_2	1121405.dsmv_2183	1.92e-19	84.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,42M8E@68525|delta/epsilon subdivisions,2WJH0@28221|Deltaproteobacteria,2MNE9@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
k59_422379_1	765912.Thimo_2264	1.86e-96	301.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria,1WWCP@135613|Chromatiales	135613|Chromatiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_1771996_1	1158292.JPOE01000002_gene1616	4e-53	178.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2VHAX@28216|Betaproteobacteria,1KJDB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Rhodanese Homology Domain	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_422383_1	713586.KB900536_gene918	9.25e-21	90.9	COG2188@1|root,COG2188@2|Bacteria,1R4G0@1224|Proteobacteria,1S1B1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator GntR family	-	-	-	-	-	-	-	-	-	-	-	-	GntR,UTRA
k59_422383_2	1159870.KB907784_gene1470	8.51e-05	45.4	COG3181@1|root,COG3181@2|Bacteria,1MY36@1224|Proteobacteria,2VJK1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_1655993_1	471853.Bcav_1809	9.2e-55	179.0	2AZHQ@1|root,31RRW@2|Bacteria,2ICDB@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_897266_1	177437.HRM2_38700	3.31e-105	322.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MHYC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_1186234_1	216596.RL1237	9.67e-91	289.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,4B9AV@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1125348_1	590998.Celf_1118	3.32e-153	445.0	COG0138@1|root,COG0138@2|Bacteria,2GJWU@201174|Actinobacteria,4F1N9@85016|Cellulomonadaceae	201174|Actinobacteria	F	PFAM AICARFT IMPCHase bienzyme formylation region	purH	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_1072032_1	616991.JPOO01000003_gene799	6.32e-120	363.0	COG3547@1|root,COG3547@2|Bacteria,4NGED@976|Bacteroidetes,1HYRZ@117743|Flavobacteriia,23ID0@178469|Arenibacter	976|Bacteroidetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_188134_1	237368.SCABRO_04028	3.67e-19	90.9	COG0644@1|root,COG0664@1|root,COG0644@2|Bacteria,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	prnA	-	1.14.19.9	ko:K07058,ko:K14266	ko00404,ko01130,map00404,map01130	M00789,M00790	R09570	RC00949	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_5,Trp_halogenase,cNMP_binding
k59_1713528_1	886293.Sinac_4404	2.42e-47	164.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
k59_1713528_2	861360.AARI_12500	1.8e-44	151.0	COG1101@1|root,COG1101@2|Bacteria,2GNP6@201174|Actinobacteria,1W7P6@1268|Micrococcaceae	201174|Actinobacteria	S	ABC transporter	-	-	-	ko:K05833	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
k59_956298_1	713586.KB900536_gene2207	3.28e-138	407.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	lpdG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iE2348C_1286.E2348C_4372,iJN746.PP_4187	Pyr_redox_2,Pyr_redox_dim
k59_772900_1	1248232.BANQ01000029_gene3948	2.29e-27	118.0	COG3187@1|root,COG4461@1|root,COG3187@2|Bacteria,COG4461@2|Bacteria,1PF0Q@1224|Proteobacteria,1TBDV@1236|Gammaproteobacteria,1XWBZ@135623|Vibrionales	135623|Vibrionales	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
k59_598318_1	933262.AXAM01000077_gene1702	6.01e-115	343.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2WJBH@28221|Deltaproteobacteria,2MJ0H@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_1595922_1	1144275.COCOR_07465	3.76e-05	52.0	COG0699@1|root,COG0699@2|Bacteria,1RKUD@1224|Proteobacteria,432KX@68525|delta/epsilon subdivisions,2WYCG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	50S ribosome-binding GTPase	-	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
k59_1247471_1	290397.Adeh_1531	6.56e-85	265.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,42N4P@68525|delta/epsilon subdivisions,2WJ0B@28221|Deltaproteobacteria,2YTW5@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_75550_1	652103.Rpdx1_0565	1.59e-68	230.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2TRMJ@28211|Alphaproteobacteria,3JT3T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	ATP-dependent helicase	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_129463_1	1131269.AQVV01000007_gene1011	2.96e-79	253.0	COG0147@1|root,COG0147@2|Bacteria	2|Bacteria	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_129463_2	1192034.CAP_5285	1.2e-05	46.2	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,42QTS@68525|delta/epsilon subdivisions,2WN02@28221|Deltaproteobacteria,2YXCZ@29|Myxococcales	28221|Deltaproteobacteria	EH	Peptidase C26	trpG	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2496	GATase
k59_1482535_1	446471.Xcel_3345	1.72e-105	321.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,2H7WY@201174|Actinobacteria,4F54S@85017|Promicromonosporaceae	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Reductase_C,Rhodanese
k59_1595929_1	622637.KE124774_gene3956	2.35e-92	287.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,36X9F@31993|Methylocystaceae	28211|Alphaproteobacteria	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.1,6.2.1.16	ko:K01895,ko:K01907	ko00010,ko00280,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00280,map00620,map00640,map00650,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354,R01357	RC00004,RC00012,RC00014,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1247483_1	1441930.Z042_11685	3.38e-22	102.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,3ZZJS@613|Serratia	1236|Gammaproteobacteria	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.98.3	ko:K02495	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R06895	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI39_1322.ECIAI39_3134,iZ_1308.Z5403	HemN_C,Radical_SAM
k59_20016_1	1232410.KI421424_gene1839	1.3e-67	219.0	COG0477@1|root,COG2814@2|Bacteria,1QUY6@1224|Proteobacteria,43DH9@68525|delta/epsilon subdivisions,2X8P2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_369060_1	1190606.AJYG01000171_gene107	2.24e-77	247.0	COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,1RYAY@1236|Gammaproteobacteria,1XTDW@135623|Vibrionales	135623|Vibrionales	S	unusual protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
k59_1186265_1	497964.CfE428DRAFT_0064	2.9e-20	86.3	COG1595@1|root,COG1595@2|Bacteria,46VJP@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2
k59_716417_1	795797.C497_05357	1.66e-35	137.0	COG0733@1|root,arCOG04466@2157|Archaea,2XTG1@28890|Euryarchaeota,23SDV@183963|Halobacteria	183963|Halobacteria	P	COG0733 Na -dependent transporters of the SNF family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_253634_1	519989.ECTPHS_13962	1.94e-61	195.0	2CIH3@1|root,32KXU@2|Bacteria,1RJBB@1224|Proteobacteria,1S7QK@1236|Gammaproteobacteria,1X0SX@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1595942_1	381666.H16_B0949	4.62e-31	124.0	COG3303@1|root,COG3303@2|Bacteria,1R5JF@1224|Proteobacteria	1224|Proteobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C552,Cytochrom_c3_2
k59_253637_1	553184.ATORI0001_1258	1.42e-18	90.1	COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,4CU8E@84998|Coriobacteriia	84998|Coriobacteriia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1072102_1	686340.Metal_1461	1.97e-79	249.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1XEMS@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_129486_1	472759.Nhal_1958	1.57e-139	413.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,1TK7U@1236|Gammaproteobacteria,1X089@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8
k59_253639_1	261292.Nit79A3_2165	2.16e-112	335.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2VID7@28216|Betaproteobacteria,371RE@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_253639_2	910964.GEAM_3290	4.43e-61	193.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_1125382_1	1032480.MLP_30730	1.29e-21	92.8	2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria,4DQPC@85009|Propionibacteriales	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
k59_1125382_2	479431.Namu_0684	6.26e-07	53.1	2EU3S@1|root,33MKJ@2|Bacteria,2GXJD@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1007874_1	768671.ThimaDRAFT_2993	2.29e-100	308.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,1T1W9@1236|Gammaproteobacteria,1WW1S@135613|Chromatiales	135613|Chromatiales	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_897333_1	935839.JAGJ01000006_gene3365	4.03e-125	365.0	COG2170@1|root,COG2170@2|Bacteria,2GKAA@201174|Actinobacteria,4F3DU@85017|Promicromonosporaceae	201174|Actinobacteria	H	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	ybdK	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
k59_540056_1	1027273.GZ77_26030	7.93e-88	270.0	COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,1RZTT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	to GP 6723233	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1595974_1	1122214.AQWH01000009_gene2057	9.28e-06	47.0	COG3703@1|root,COG3703@2|Bacteria,1QWR3@1224|Proteobacteria,2TZMS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Gamma-glutamyl cyclotransferase, AIG2-like	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1595974_2	582899.Hden_2869	1.02e-22	97.1	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2TUFV@28211|Alphaproteobacteria,3N6X5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_1656063_1	864051.BurJ1DRAFT_2687	3.12e-08	54.7	COG2391@1|root,COG2391@2|Bacteria,1RIWE@1224|Proteobacteria,2VWMP@28216|Betaproteobacteria,1KNZM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_1656063_2	945713.IALB_1660	1.11e-47	160.0	COG2391@1|root,COG2391@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_716460_1	1266914.ATUK01000010_gene1152	5.56e-73	230.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,1T0C6@1236|Gammaproteobacteria,1WXH4@135613|Chromatiales	135613|Chromatiales	C	PFAM Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_1482603_1	136273.GY22_01815	2.81e-99	310.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,1W837@1268|Micrococcaceae	201174|Actinobacteria	L	DEAD DEAH box helicase	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C
k59_1537593_1	519989.ECTPHS_09433	1.82e-69	222.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,1WW1U@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM A G-specific adenine glycosylase	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,NUDIX_4
k59_188207_1	1042375.AFPL01000044_gene1280	1.14e-82	258.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,4642Y@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	gtrB	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1247553_1	1265503.KB905160_gene2871	3.73e-49	177.0	28HKI@1|root,2Z7VC@2|Bacteria,1MW0I@1224|Proteobacteria,1RQ5H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_188209_1	1151126.AQYI01000002_gene283	1.81e-38	132.0	COG1539@1|root,COG1539@2|Bacteria,2IHSW@201174|Actinobacteria,4FPAQ@85023|Microbacteriaceae	201174|Actinobacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	GO:0008150,GO:0040007	1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8	ko:K01633,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00840	R03503,R03504,R11037,R11073	RC00002,RC00017,RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
k59_188209_2	1120950.KB892801_gene1722	8.21e-06	47.4	COG0801@1|root,COG0801@2|Bacteria,2H3G6@201174|Actinobacteria,4DQ88@85009|Propionibacteriales	201174|Actinobacteria	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
k59_305049_1	1321779.HMPREF1984_01176	0.000299	46.2	COG2801@1|root,COG2801@2|Bacteria,378T6@32066|Fusobacteria	32066|Fusobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_2
k59_305049_2	1191523.MROS_0351	3.07e-16	73.6	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_75634_1	754477.Q7C_1002	3.9e-84	267.0	COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,1RPDG@1236|Gammaproteobacteria,460CE@72273|Thiotrichales	72273|Thiotrichales	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_1421276_1	1121405.dsmv_2138	8.84e-75	233.0	COG0589@1|root,COG0589@2|Bacteria,1R51N@1224|Proteobacteria,42PVP@68525|delta/epsilon subdivisions,2WKQB@28221|Deltaproteobacteria,2MINR@213118|Desulfobacterales	28221|Deltaproteobacteria	T	response to stress	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_716466_1	1469245.JFBG01000038_gene1836	7.06e-50	168.0	COG4521@1|root,COG4521@2|Bacteria,1MVH2@1224|Proteobacteria,1RRRT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	taurine ABC transporter	-	-	-	ko:K15551	ko00920,ko02010,map00920,map02010	M00435	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.17.1,3.A.1.17.4	-	-	NMT1
k59_1713599_1	396588.Tgr7_3004	1.68e-59	192.0	COG1999@1|root,COG1999@2|Bacteria	2|Bacteria	M	signal sequence binding	VVA1110	-	-	-	-	-	-	-	-	-	-	-	-
k59_1421277_1	1082933.MEA186_30901	1.46e-39	150.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_1072162_1	1049564.TevJSym_as00370	8.4e-95	282.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,1J5SJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036220,GO:0036222,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046983,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	iEC55989_1330.EC55989_3247,iECO111_1330.ECO111_3702,iECSE_1348.ECSE_3222,iECW_1372.ECW_m3212,iEKO11_1354.EKO11_0774,iEcE24377_1341.EcE24377A_3298,iWFL_1372.ECW_m3212	Ham1p_like
k59_75644_1	196162.Noca_3273	3.35e-48	180.0	COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,4DN2T@85009|Propionibacteriales	201174|Actinobacteria	D	Required for chromosome condensation and partitioning	smc	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_1777825_1	1121405.dsmv_0511	1.16e-37	140.0	COG0569@1|root,COG0589@1|root,COG0569@2|Bacteria,COG0589@2|Bacteria,1QZ59@1224|Proteobacteria,43CFV@68525|delta/epsilon subdivisions,2WR2F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TrkA-N domain	-	-	-	ko:K03499,ko:K09944	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N,Usp
k59_377153_1	933262.AXAM01000036_gene2166	1.09e-54	177.0	COG1691@1|root,COG1691@2|Bacteria,1REQ7@1224|Proteobacteria,42MJG@68525|delta/epsilon subdivisions,2WN0G@28221|Deltaproteobacteria,2MJ1E@213118|Desulfobacterales	28221|Deltaproteobacteria	S	(AIR) carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
k59_1543334_1	572477.Alvin_2543	1.45e-93	282.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1WXEN@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_1316577_2	2340.JV46_16230	1.57e-29	112.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1J4D2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006015,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042301,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046391,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b1207,iAPECO1_1312.APECO1_323,iB21_1397.B21_01192,iBWG_1329.BWG_1032,iE2348C_1286.E2348C_1330,iEC042_1314.EC042_1264,iEC55989_1330.EC55989_1303,iECABU_c1320.ECABU_c14780,iECBD_1354.ECBD_2414,iECB_1328.ECB_01182,iECDH10B_1368.ECDH10B_1260,iECDH1ME8569_1439.ECDH1ME8569_1146,iECD_1391.ECD_01182,iECED1_1282.ECED1_1355,iECH74115_1262.ECH74115_1688,iECIAI1_1343.ECIAI1_1228,iECIAI39_1322.ECIAI39_1543,iECNA114_1301.ECNA114_1372,iECO103_1326.ECO103_1309,iECO111_1330.ECO111_1536,iECO26_1355.ECO26_1720,iECOK1_1307.ECOK1_1360,iECP_1309.ECP_1255,iECS88_1305.ECS88_1275,iECSE_1348.ECSE_1257,iECSF_1327.ECSF_1183,iECSP_1301.ECSP_1597,iECUMN_1333.ECUMN_1504,iECW_1372.ECW_m1293,iECs_1301.ECs1712,iEKO11_1354.EKO11_2647,iETEC_1333.ETEC_1311,iEcDH1_1363.EcDH1_2440,iEcE24377_1341.EcE24377A_1355,iEcHS_1320.EcHS_A1312,iEcSMS35_1347.EcSMS35_1935,iEcolC_1368.EcolC_2419,iG2583_1286.G2583_1478,iJO1366.b1207,iJR904.b1207,iLF82_1304.LF82_1744,iNRG857_1313.NRG857_06180,iSBO_1134.SBO_1860,iSDY_1059.SDY_1256,iSSON_1240.SSON_1971,iUMN146_1321.UM146_11025,iUMNK88_1353.UMNK88_1523,iUTI89_1310.UTI89_C1401,iWFL_1372.ECW_m1293,iY75_1357.Y75_RS06300,ic_1306.c1665	Pribosyl_synth,Pribosyltran_N
k59_27571_1	1304865.JAGF01000001_gene2498	1.16e-43	155.0	COG2723@1|root,COG2723@2|Bacteria,2GJAF@201174|Actinobacteria,4F0XE@85016|Cellulomonadaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 1	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
k59_27571_2	1454010.JEOE01000003_gene268	1.53e-37	134.0	COG0395@1|root,COG0395@2|Bacteria,2GK1V@201174|Actinobacteria,4F1QY@85016|Cellulomonadaceae	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026,ko:K10242	ko02010,map02010	M00206,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.23	-	-	BPD_transp_1
k59_1080909_1	1500897.JQNA01000002_gene3312	2.59e-104	314.0	COG3385@1|root,COG3385@2|Bacteria,1R9HB@1224|Proteobacteria,2VMI8@28216|Betaproteobacteria,1K64D@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_261504_1	96561.Dole_2483	2.67e-83	269.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MIJD@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_663548_1	1430440.MGMSRv2_2000	0.000111	43.9	COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,2TURW@28211|Alphaproteobacteria,2JPFC@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome c-type protein	-	-	-	ko:K02569	-	-	-	-	ko00000	-	-	-	Cytochrom_NNT
k59_663548_2	631362.Thi970DRAFT_02377	9.3e-07	54.7	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,1SYJF@1236|Gammaproteobacteria,1WXTI@135613|Chromatiales	135613|Chromatiales	S	PFAM Ankyrin	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4,Ank_5
k59_1130409_1	1453500.AT05_01505	3.91e-26	108.0	COG4974@1|root,COG4974@2|Bacteria,4NGE1@976|Bacteroidetes,1HY1D@117743|Flavobacteriia	976|Bacteroidetes	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_135272_1	1379281.AVAG01000021_gene1115	2.22e-55	189.0	COG1906@1|root,COG1906@2|Bacteria,1RAQQ@1224|Proteobacteria,42QZ0@68525|delta/epsilon subdivisions,2WMXK@28221|Deltaproteobacteria,2M7VJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF401)	-	-	-	ko:K09133	-	-	-	-	ko00000	-	-	-	DUF401
k59_261522_1	1304865.JAGF01000001_gene585	1.16e-78	248.0	COG2252@1|root,COG2252@2|Bacteria,2GKYD@201174|Actinobacteria,4F0DV@85016|Cellulomonadaceae	201174|Actinobacteria	S	Permease family	pbuG	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
k59_1080924_1	713586.KB900536_gene68	2.93e-174	494.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,1WVY0@135613|Chromatiales	135613|Chromatiales	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_27600_1	999425.HMPREF9186_00809	4.59e-11	63.2	COG1704@1|root,COG1704@2|Bacteria,1V1G7@1239|Firmicutes,4IR1J@91061|Bacilli	91061|Bacilli	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_1719342_1	472759.Nhal_1189	2.01e-112	353.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_663556_1	1304865.JAGF01000001_gene2258	4.46e-132	377.0	COG0300@1|root,COG0300@2|Bacteria,2H30G@201174|Actinobacteria	201174|Actinobacteria	S	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_663556_2	1185766.DL1_15325	7.49e-28	117.0	COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,2TSV7@28211|Alphaproteobacteria,2XMF4@285107|Thioclava	28211|Alphaproteobacteria	C	Belongs to the cytochrome P450 family	-	-	-	-	-	-	-	-	-	-	-	-	p450
k59_604045_1	765912.Thimo_2377	1.48e-73	231.0	COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,1WXUQ@135613|Chromatiales	135613|Chromatiales	EH	PFAM Aminotransferase, class IV	-	-	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	-	Aminotran_4
k59_1080934_1	391165.GbCGDNIH1_0405	1.16e-21	94.7	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2TVBT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
k59_310859_1	1049564.TevJSym_an00350	1.55e-146	419.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1J4E7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2476,iB21_1397.B21_02330,iBWG_1329.BWG_2240,iE2348C_1286.E2348C_2713,iEC042_1314.EC042_2677,iEC55989_1330.EC55989_2759,iECABU_c1320.ECABU_c27880,iECBD_1354.ECBD_1213,iECB_1328.ECB_02368,iECDH10B_1368.ECDH10B_2642,iECDH1ME8569_1439.ECDH1ME8569_2402,iECDH1ME8569_1439.EcDH1_1193,iECD_1391.ECD_02368,iECED1_1282.ECED1_2911,iECH74115_1262.ECH74115_3698,iECIAI1_1343.ECIAI1_2527,iECNA114_1301.ECNA114_2561,iECO103_1326.ECO103_2988,iECO111_1330.ECO111_3199,iECO26_1355.ECO26_3522,iECOK1_1307.ECOK1_2784,iECP_1309.ECP_2490,iECS88_1305.ECS88_2658,iECSE_1348.ECSE_2760,iECSF_1327.ECSF_2329,iECSP_1301.ECSP_3415,iECUMN_1333.ECUMN_2789,iECW_1372.ECW_m2698,iECs_1301.ECs3338,iEKO11_1354.EKO11_1259,iETEC_1333.ETEC_2581,iEcDH1_1363.EcDH1_1193,iEcE24377_1341.EcE24377A_2757,iEcHS_1320.EcHS_A2607,iEcSMS35_1347.EcSMS35_2623,iEcolC_1368.EcolC_1200,iG2583_1286.G2583_2999,iJN746.PP_1240,iJO1366.b2476,iJR904.b2476,iLF82_1304.LF82_1775,iNRG857_1313.NRG857_12360,iSFV_1184.SFV_2521,iSF_1195.SF2519,iSFxv_1172.SFxv_2773,iS_1188.S2669,iSbBS512_1146.SbBS512_E2848,iUMNK88_1353.UMNK88_3071,iWFL_1372.ECW_m2698,iY75_1357.Y75_RS12925,iYL1228.KPN_02810,iZ_1308.Z3735	SAICAR_synt
k59_310859_2	672.VV93_v1c42870	4.31e-52	167.0	COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_27611_1	1121405.dsmv_1838	7.61e-100	311.0	COG0123@1|root,COG0454@1|root,COG0123@2|Bacteria,COG0456@2|Bacteria,1MU7P@1224|Proteobacteria,42NAQ@68525|delta/epsilon subdivisions,2WJPX@28221|Deltaproteobacteria,2MK5E@213118|Desulfobacterales	28221|Deltaproteobacteria	BKQ	Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Hist_deacetyl
k59_1130425_1	795666.MW7_2050	1.15e-39	139.0	COG2032@1|root,COG2032@2|Bacteria,1N26J@1224|Proteobacteria,2VT83@28216|Betaproteobacteria,1KI6D@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodC	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
k59_1543364_1	216596.RL1865	2.28e-12	67.4	COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,2TQYU@28211|Alphaproteobacteria,4BAV7@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	hydrolase	-	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
k59_1543364_2	1122604.JONR01000010_gene3918	6.72e-60	195.0	COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,1RQG2@1236|Gammaproteobacteria,1X9FW@135614|Xanthomonadales	135614|Xanthomonadales	Q	homogentisate 1,2-dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	HgmA
k59_1719349_1	768671.ThimaDRAFT_1689	5.67e-122	358.0	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales	135613|Chromatiales	P	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
k59_1661961_1	634497.HAH_5051	2.89e-07	55.5	COG0589@1|root,arCOG00449@2157|Archaea,2XVPB@28890|Euryarchaeota,23SHQ@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1316619_1	998088.B565_2886	2.14e-46	165.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,1Y4J4@135624|Aeromonadales	135624|Aeromonadales	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
k59_545472_1	614083.AWQR01000009_gene619	7.41e-38	130.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2VR52@28216|Betaproteobacteria,4ADIN@80864|Comamonadaceae	28216|Betaproteobacteria	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_545472_2	765914.ThisiDRAFT_0073	5.04e-45	162.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1WW15@135613|Chromatiales	135613|Chromatiales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_1601614_1	396588.Tgr7_0816	3.1e-33	122.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,1RNV4@1236|Gammaproteobacteria,1WX0I@135613|Chromatiales	135613|Chromatiales	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
k59_1601614_2	1288826.MSNKSG1_18530	6.92e-58	189.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,4643F@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432	PseudoU_synth_2,S4
k59_1489806_1	1042209.HK44_021600	3.75e-153	442.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,1RRMU@1236|Gammaproteobacteria,1YU3Y@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	L	Endonuclease DDE	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_28,HTH_32
k59_663569_1	983545.Glaag_0544	2.56e-51	162.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,1S5VT@1236|Gammaproteobacteria,4677X@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_1316628_1	574966.KB898646_gene3216	2.08e-17	78.2	COG3187@1|root,COG3187@2|Bacteria,1RE51@1224|Proteobacteria,1T10Y@1236|Gammaproteobacteria,1XRR6@135619|Oceanospirillales	135619|Oceanospirillales	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
k59_1316628_2	1121405.dsmv_1555	3.86e-41	139.0	COG2050@1|root,COG2050@2|Bacteria,1PP3W@1224|Proteobacteria,42T4V@68525|delta/epsilon subdivisions,2WPWD@28221|Deltaproteobacteria,2MK3H@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_135296_2	425104.Ssed_2798	1.86e-82	272.0	COG0437@1|root,COG3302@1|root,COG0437@2|Bacteria,COG3302@2|Bacteria,1MU1B@1224|Proteobacteria,1SYHX@1236|Gammaproteobacteria,2QBCU@267890|Shewanellaceae	1236|Gammaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K07307	ko00920,map00920	-	R09501	RC02555	ko00000,ko00001,ko02000	5.A.3.3	-	-	DmsC,Fer4_11,Fer4_4
k59_1777871_1	1454004.AW11_01265	2.06e-20	91.3	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,2VPFR@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_486908_1	1123065.ATWL01000001_gene164	4.99e-76	240.0	28PUQ@1|root,2ZCFK@2|Bacteria,2GNQM@201174|Actinobacteria	201174|Actinobacteria	S	DNA-binding protein	-	GO:0008150,GO:0040007	-	-	-	-	-	-	-	-	-	-	DUF3071
k59_839358_1	1444770.AF72_08765	1.19e-08	64.3	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1X58E@135614|Xanthomonadales	135614|Xanthomonadales	Q	ORF located using	-	-	-	-	-	-	-	-	-	-	-	-	HCBP_related,HemolysinCabind
k59_135303_1	765910.MARPU_03930	2.75e-196	565.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales	135613|Chromatiales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_193947_1	345219.Bcoa_2914	6.64e-13	72.4	COG1354@1|root,COG1354@2|Bacteria,1TRW3@1239|Firmicutes,4HA6Q@91061|Bacilli,1ZDD6@1386|Bacillus	91061|Bacilli	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
k59_28800_2	323261.Noc_2823	5.96e-70	215.0	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria,1WY8C@135613|Chromatiales	135613|Chromatiales	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
k59_28800_3	519989.ECTPHS_01359	5.43e-42	147.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1WXMZ@135613|Chromatiales	135613|Chromatiales	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_1081876_1	1095767.CAHD01000045_gene1387	3.38e-148	429.0	COG1587@1|root,COG3710@1|root,COG1587@2|Bacteria,COG3710@2|Bacteria,2GKMM@201174|Actinobacteria,4F0R3@85016|Cellulomonadaceae	201174|Actinobacteria	HK	PFAM Uroporphyrinogen III synthase HEM4	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,Trans_reg_C
k59_1131137_1	879212.DespoDRAFT_03029	1.07e-77	244.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,42MS9@68525|delta/epsilon subdivisions,2WJMS@28221|Deltaproteobacteria,2MI3S@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_1845729_1	1049564.TevJSym_ca00050	2.06e-81	270.0	COG1033@1|root,COG2834@1|root,COG1033@2|Bacteria,COG2834@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1J96Q@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	MMPL family	VP1286	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_906391_1	105559.Nwat_2706	4.54e-58	189.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,1RZ45@1236|Gammaproteobacteria,1WWNT@135613|Chromatiales	135613|Chromatiales	S	Metallophosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
k59_906391_2	314278.NB231_13051	4.58e-42	144.0	COG0575@1|root,COG0575@2|Bacteria,1N4I3@1224|Proteobacteria,1SASF@1236|Gammaproteobacteria,1WZ0R@135613|Chromatiales	135613|Chromatiales	I	CDP-archaeol synthase	-	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
k59_262703_1	314278.NB231_12284	5.2e-46	154.0	COG0494@1|root,COG0494@2|Bacteria,1MYSK@1224|Proteobacteria,1SB8U@1236|Gammaproteobacteria,1WZ0K@135613|Chromatiales	135613|Chromatiales	L	Belongs to the Nudix hydrolase family	-	-	3.6.1.17	ko:K01518	ko00230,ko00240,map00230,map00240	-	R00184,R00969,R01232,R02805	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_840026_1	1437609.BCAL_0103	4.85e-72	233.0	COG3464@1|root,COG3464@2|Bacteria,2IP45@201174|Actinobacteria,4D04T@85004|Bifidobacteriales	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_84583_1	1121405.dsmv_0649	9.38e-78	246.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2WJJ8@28221|Deltaproteobacteria,2MI9P@213118|Desulfobacterales	28221|Deltaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
k59_84583_2	160799.PBOR_35785	1.21e-10	62.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,4H9VY@91061|Bacilli,271S1@186822|Paenibacillaceae	91061|Bacilli	G	Pyruvate kinase, alpha/beta domain	pyk	GO:0001871,GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0030246,GO:0030247,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:2001065	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
k59_378140_1	935839.JAGJ01000003_gene1390	2.83e-147	441.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4F3R6@85017|Promicromonosporaceae	201174|Actinobacteria	C	Aconitase family (aconitate hydratase)	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_1845747_1	247633.GP2143_11302	1.04e-29	115.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	cpoB	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	TPR_16,TPR_6,TolA_bind_tri,YfiO
k59_1081894_1	1517416.IDAT_00555	7.61e-17	75.5	COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,1SD8H@1236|Gammaproteobacteria,2QGBA@267893|Idiomarinaceae	1236|Gammaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0019954,GO:0022402,GO:0022414,GO:0030428,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044464,GO:0051301	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
k59_1081894_2	395493.BegalDRAFT_3015	1.42e-45	155.0	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria,460Q8@72273|Thiotrichales	72273|Thiotrichales	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
k59_840036_1	1134474.O59_001772	2.69e-66	214.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,1RMF8@1236|Gammaproteobacteria,1FI2S@10|Cellvibrio	1236|Gammaproteobacteria	S	Putative neutral zinc metallopeptidase	ypfJ	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
k59_1317597_1	313606.M23134_00683	3.13e-28	117.0	COG4908@1|root,COG4908@2|Bacteria,4PMCQ@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
k59_194626_2	479432.Sros_1435	5.82e-20	89.0	COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,4EICF@85012|Streptosporangiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1081897_1	1304865.JAGF01000001_gene3299	3.98e-88	268.0	COG5401@1|root,COG5401@2|Bacteria,2IQ3Y@201174|Actinobacteria	201174|Actinobacteria	S	Immunoglobulin-like domain of bacterial spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad2
k59_604791_1	1219045.BV98_000702	5.97e-38	141.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2TVFM@28211|Alphaproteobacteria,2K114@204457|Sphingomonadales	204457|Sphingomonadales	J	Metallo-beta-lactamase superfamily domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
k59_604791_2	1304865.JAGF01000001_gene2710	1.82e-14	72.0	COG2890@1|root,COG2890@2|Bacteria,2GMH1@201174|Actinobacteria,4F0XJ@85016|Cellulomonadaceae	201174|Actinobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_25,Methyltransf_31
k59_1081900_1	765912.Thimo_0945	6.14e-81	251.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,1RM7W@1236|Gammaproteobacteria,1WWKM@135613|Chromatiales	135613|Chromatiales	E	Required for the activity of the bacterial periplasmic transport system of putrescine	-	-	-	ko:K11069,ko:K11073	ko02010,map02010	M00299,M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1,3.A.1.11.2	-	-	SBP_bac_8
k59_965348_1	933262.AXAM01000019_gene1113	3.5e-52	172.0	COG5012@1|root,COG5012@2|Bacteria,1RDEU@1224|Proteobacteria,43BR3@68525|delta/epsilon subdivisions,2X720@28221|Deltaproteobacteria,2MK1P@213118|Desulfobacterales	28221|Deltaproteobacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
k59_428861_1	391593.RCCS2_01508	7.95e-72	226.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2TUQ1@28211|Alphaproteobacteria,2P518@2433|Roseobacter	28211|Alphaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
k59_84611_1	690850.Desaf_1748	1.28e-09	60.1	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,42MXS@68525|delta/epsilon subdivisions,2WKEK@28221|Deltaproteobacteria,2M8WD@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Seven times multi-haem cytochrome CxxCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Multi-haem_cyto
k59_1720107_1	697282.Mettu_2634	1.73e-74	236.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1XEJ4@135618|Methylococcales	135618|Methylococcales	I	acetyl-CoA carboxylase, biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_1602313_2	1521187.JPIM01000003_gene3013	8.03e-12	66.2	COG0438@1|root,COG0438@2|Bacteria,2G5PS@200795|Chloroflexi,375CY@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_664284_1	1122164.JHWF01000045_gene1372	3.19e-104	334.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1JC97@118969|Legionellales	118969|Legionellales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1427814_1	1049564.TevJSym_az00370	3.4e-96	289.0	COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,1RPYF@1236|Gammaproteobacteria,1J596@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	ABC-type Mn2 Zn2 transport systems, permease	znuB	-	-	ko:K02075,ko:K09816	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
k59_84634_1	472759.Nhal_0092	1.25e-74	249.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWNH@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_428879_1	406327.Mevan_0205	3.38e-73	231.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,23QJ1@183939|Methanococci	183939|Methanococci	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
k59_1778687_1	1519464.HY22_01480	1.05e-55	198.0	COG0841@1|root,COG0841@2|Bacteria	2|Bacteria	V	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1013312_1	926564.KI911740_gene3441	6.5e-105	328.0	COG3280@1|root,COG3280@2|Bacteria,2GJTB@201174|Actinobacteria,4F4AA@85017|Promicromonosporaceae	201174|Actinobacteria	G	Alpha amylase, catalytic domain	treY	GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
k59_976313_1	335543.Sfum_1666	4.75e-34	125.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,42RTC@68525|delta/epsilon subdivisions,2WNQ6@28221|Deltaproteobacteria,2MQGR@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_976313_2	1123371.ATXH01000004_gene1691	1.23e-23	99.4	COG0436@1|root,COG0436@2|Bacteria,2GGVQ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_783994_1	583355.Caka_0079	4.49e-31	125.0	COG0815@1|root,COG0815@2|Bacteria,46W4F@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Transfers the fatty acyl group on membrane lipoproteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1726842_1	1082933.MEA186_30901	4.1e-31	125.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_95457_1	1248760.ANFZ01000012_gene19	1.31e-17	80.1	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2VEQM@28211|Alphaproteobacteria,2K45W@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_95457_2	1123269.NX02_13735	6.34e-44	151.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2TT1R@28211|Alphaproteobacteria,2K262@204457|Sphingomonadales	204457|Sphingomonadales	E	HMGL-like	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
k59_976328_1	2340.JV46_15050	4.06e-59	190.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1J513@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_1018892_1	644282.Deba_1795	2.26e-23	90.1	COG1652@1|root,COG1652@2|Bacteria,1MYYF@1224|Proteobacteria,42SCF@68525|delta/epsilon subdivisions,2WPR6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1018892_2	1232437.KL661986_gene3647	2.25e-158	461.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,42N7M@68525|delta/epsilon subdivisions,2WIJ0@28221|Deltaproteobacteria,2MITQ@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_1856847_1	1120936.KB907211_gene358	4.82e-29	115.0	COG1120@1|root,COG1120@2|Bacteria,2GN5T@201174|Actinobacteria,4EITZ@85012|Streptosporangiales	201174|Actinobacteria	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_1498367_1	335543.Sfum_0711	2.49e-30	118.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,42MNR@68525|delta/epsilon subdivisions,2WJ70@28221|Deltaproteobacteria,2MQFU@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Elongator protein 3, MiaB family, Radical SAM	kamA2	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
k59_1328557_1	765911.Thivi_3983	2.95e-40	139.0	COG0529@1|root,COG0529@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria,1WY0V@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
k59_552816_1	883126.HMPREF9710_02023	3.26e-28	121.0	COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,2VJ4I@28216|Betaproteobacteria,473HP@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Phosphate acyltransferases	aas	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	Acyltransferase,MFS_1
k59_1263914_2	95619.PM1_0218070	1.36e-49	177.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iSFV_1184.SFV_2673	ACT_4,HD_4,RelA_SpoT,TGS
k59_1784646_1	1122182.KB903813_gene2240	1.2e-12	73.2	COG0477@1|root,COG2814@2|Bacteria,2GJU2@201174|Actinobacteria,4DBGR@85008|Micromonosporales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_784013_1	477184.KYC_27488	1.46e-21	94.4	COG0491@1|root,COG0491@2|Bacteria,1PHBX@1224|Proteobacteria,2VVQS@28216|Betaproteobacteria,3T8AC@506|Alcaligenaceae	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.1.1.81	ko:K13075	ko02024,map02024	-	R08970	RC00713	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
k59_435419_1	1266909.AUAG01000003_gene852	7.8e-116	353.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales	135613|Chromatiales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_494183_1	104623.Ser39006_03352	3.78e-34	135.0	COG0318@1|root,COG3321@1|root,COG0318@2|Bacteria,COG3321@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria,404DK@613|Serratia	1236|Gammaproteobacteria	IQ	AMP-binding enzyme	-	-	-	ko:K00666,ko:K13614	-	-	-	-	ko00000,ko01000,ko01004,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Aminotran_3,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NAD_binding_4,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
k59_917306_1	1131814.JAFO01000001_gene4685	6.87e-18	82.8	COG1053@1|root,COG1053@2|Bacteria,1MURY@1224|Proteobacteria,2TSRQ@28211|Alphaproteobacteria,3F1U8@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
k59_1498388_1	1121921.KB898708_gene1627	1.44e-65	211.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,1RMYP@1236|Gammaproteobacteria,2PMHS@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.4.1.15	ko:K05396	ko00270,map00270	-	R01874	RC00382	ko00000,ko00001,ko01000	-	-	-	PALP
k59_39406_2	426114.THI_0308	1.06e-11	62.0	COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria,2VTC8@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_1856887_1	857087.Metme_4265	1.28e-57	199.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1XDRF@135618|Methylococcales	135618|Methylococcales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
k59_1856887_2	498211.CJA_3586	2.61e-46	159.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1S610@1236|Gammaproteobacteria,1FGZ4@10|Cellvibrio	1236|Gammaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate	tsaC	GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061710,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
k59_729186_1	525904.Tter_1645	3.23e-33	126.0	COG0332@1|root,COG0332@2|Bacteria,2NNX5@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_976388_1	1144275.COCOR_01446	4.29e-85	272.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,2YZUW@29|Myxococcales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1263940_1	1121403.AUCV01000013_gene3911	7.98e-39	148.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2WJTI@28221|Deltaproteobacteria,2MJ12@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Na Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
k59_1089888_1	713587.THITH_10750	4.44e-64	204.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1WW2U@135613|Chromatiales	135613|Chromatiales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1089888_2	765910.MARPU_06765	5.89e-90	273.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,1WXGF@135613|Chromatiales	135613|Chromatiales	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_389040_1	396588.Tgr7_0079	6.91e-222	645.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales	135613|Chromatiales	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1328623_1	1906.SFRA_22050	7.94e-120	365.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX1	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_318480_1	396595.TK90_2602	1.04e-27	105.0	COG0594@1|root,COG0594@2|Bacteria,1MZQE@1224|Proteobacteria,1S90M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031974,GO:0031981,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
k59_318480_2	395493.BegalDRAFT_1138	1.03e-06	52.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,45ZXV@72273|Thiotrichales	72273|Thiotrichales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_1498402_1	519989.ECTPHS_01944	5.96e-44	154.0	COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,1RNPD@1236|Gammaproteobacteria,1WWH6@135613|Chromatiales	135613|Chromatiales	D	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity	zapD	-	-	ko:K18778	-	-	-	-	ko00000,ko03036	-	-	-	ZapD
k59_729197_1	1458275.AZ34_06985	1.12e-26	119.0	COG2887@1|root,COG2887@2|Bacteria,1MY2G@1224|Proteobacteria,2VJF3@28216|Betaproteobacteria,4AB66@80864|Comamonadaceae	28216|Betaproteobacteria	L	PD-(D/E)XK nuclease superfamily	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
k59_729197_2	396588.Tgr7_2124	3.65e-64	223.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1WWH2@135613|Chromatiales	135613|Chromatiales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1137372_1	1535422.ND16A_0875	5.55e-39	145.0	COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1RMXU@1236|Gammaproteobacteria,2Q61F@267889|Colwelliaceae	1236|Gammaproteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21.2	-	-	SSF
k59_1137372_2	1068980.ARVW01000001_gene6167	3.61e-41	158.0	COG3497@1|root,COG3497@2|Bacteria,2GMJA@201174|Actinobacteria	201174|Actinobacteria	S	tail sheath protein	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
k59_1784680_3	573413.Spirs_3837	1.72e-06	51.2	COG0604@1|root,COG0604@2|Bacteria,2JAG1@203691|Spirochaetes	203691|Spirochaetes	C	Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N_2
k59_494216_1	1265505.ATUG01000002_gene1234	3.02e-17	85.9	COG1196@1|root,COG1196@2|Bacteria,1MVMQ@1224|Proteobacteria,42NF4@68525|delta/epsilon subdivisions,2WIMP@28221|Deltaproteobacteria,2MJAB@213118|Desulfobacterales	28221|Deltaproteobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1498415_1	543728.Vapar_5759	2e-57	193.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2VHPW@28216|Betaproteobacteria,4AABT@80864|Comamonadaceae	28216|Betaproteobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_494218_1	247634.GPB2148_943	1.49e-65	206.0	COG2930@1|root,COG2930@2|Bacteria,1RCYH@1224|Proteobacteria,1S41U@1236|Gammaproteobacteria,1J6CJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	s cog2930	CT2216	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_1726907_1	243090.RB5406	3.31e-25	107.0	COG1070@1|root,COG1070@2|Bacteria,2IXYW@203682|Planctomycetes	203682|Planctomycetes	G	COG1070 Sugar (pentulose and hexulose)	-	-	2.7.1.5	ko:K00848	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R03014	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
k59_318500_1	1123228.AUIH01000012_gene86	2.27e-70	227.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1XHSI@135619|Oceanospirillales	135619|Oceanospirillales	P	Trk system potassium uptake protein	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_552882_1	1121428.DESHY_60130___1	7.84e-21	95.9	COG0213@1|root,COG0213@2|Bacteria,1TPCH@1239|Firmicutes,24848@186801|Clostridia,2609M@186807|Peptococcaceae	186801|Clostridia	F	TIGRFAM Pyrimidine-nucleoside phosphorylase	pdp	-	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS08925	Glycos_trans_3N,Glycos_transf_3,PYNP_C
k59_494223_1	391038.Bphy_1088	4e-58	190.0	COG4313@1|root,COG4313@2|Bacteria,1PRCN@1224|Proteobacteria,2VQHT@28216|Betaproteobacteria,1K45B@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
k59_784062_1	572477.Alvin_2582	9.6e-29	108.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,1RMD0@1236|Gammaproteobacteria,1WVXR@135613|Chromatiales	135613|Chromatiales	K	response regulator receiver	-	-	-	ko:K07664	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_494230_1	1121935.AQXX01000132_gene2616	4.92e-29	122.0	COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1XHS8@135619|Oceanospirillales	135619|Oceanospirillales	DM	COG3264 Small-conductance mechanosensitive channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM,MscS_porin
k59_39470_1	232348.ADXL01000066_gene2660	1.77e-102	306.0	COG0500@1|root,COG2226@2|Bacteria,1G29G@1117|Cyanobacteria,1GZA6@1129|Synechococcus	1117|Cyanobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
k59_729230_1	1121405.dsmv_1096	1.55e-51	186.0	COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,42N23@68525|delta/epsilon subdivisions,2WKW2@28221|Deltaproteobacteria,2MMXV@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K02021	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1498437_1	439235.Dalk_0331	2.61e-67	217.0	2C0YB@1|root,2ZAH2@2|Bacteria,1R8PK@1224|Proteobacteria,42QK8@68525|delta/epsilon subdivisions,2WKZK@28221|Deltaproteobacteria,2MICB@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_142501_1	765911.Thivi_4365	1.1e-35	135.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1WWEF@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_142501_2	631362.Thi970DRAFT_04587	8.21e-29	110.0	COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,1S2B6@1236|Gammaproteobacteria,1X0E4@135613|Chromatiales	135613|Chromatiales	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_846727_1	710687.KI912270_gene2423	8.42e-93	290.0	COG4974@1|root,COG4974@2|Bacteria,2IBD6@201174|Actinobacteria,236NP@1762|Mycobacteriaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
k59_272803_2	59538.XP_005974296.1	3.48e-19	82.0	COG1694@1|root,2S210@2759|Eukaryota,3A4D4@33154|Opisthokonta	33154|Opisthokonta	S	dCTP catabolic process	-	-	3.6.1.12	ko:K16904	ko00240,ko01100,map00240,map01100	-	R01667,R01668	RC00002	ko00000,ko00001,ko01000	-	-	-	MazG-like
k59_389123_2	426355.Mrad2831_2128	9.41e-25	101.0	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,2TRRU@28211|Alphaproteobacteria,1JSC1@119045|Methylobacteriaceae	28211|Alphaproteobacteria	GK	PFAM ROK family	mak	-	2.7.1.2,2.7.1.4	ko:K00845,ko:K00847	ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R00760,R00867,R01600,R01786,R03920	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_611580_1	983917.RGE_09840	5.75e-12	63.5	COG1669@1|root,COG1669@2|Bacteria,1N17I@1224|Proteobacteria,2VVYD@28216|Betaproteobacteria,1KMRY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Nucleotidyltransferase domain	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
k59_1434591_1	1122185.N792_04115	7.59e-98	299.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1X3DQ@135614|Xanthomonadales	135614|Xanthomonadales	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI
k59_1328726_1	1095767.CAHD01000210_gene2639	1.1e-44	149.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4F1CQ@85016|Cellulomonadaceae	201174|Actinobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	garA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006110,GO:0006140,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010563,GO:0010675,GO:0010677,GO:0016020,GO:0016310,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0030312,GO:0030808,GO:0030809,GO:0030811,GO:0030812,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031330,GO:0036211,GO:0042325,GO:0042326,GO:0042802,GO:0043170,GO:0043412,GO:0043457,GO:0043467,GO:0043470,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045820,GO:0045912,GO:0045934,GO:0045936,GO:0045980,GO:0046777,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051193,GO:0051195,GO:0051196,GO:0051198,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1900371,GO:1900372,GO:1900542,GO:1900543,GO:1901564,GO:1903578,GO:1903579,GO:2001169,GO:2001170	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
k59_1328726_2	1306174.JODP01000002_gene5957	2.15e-05	45.8	COG0789@1|root,COG0789@2|Bacteria,2HBV6@201174|Actinobacteria	201174|Actinobacteria	K	merR family	merR1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	MerR,MerR_1
k59_1857018_1	1283300.ATXB01000002_gene2599	1.48e-33	125.0	2E62S@1|root,330RV@2|Bacteria,1N7P9@1224|Proteobacteria,1SX03@1236|Gammaproteobacteria,1XFK7@135618|Methylococcales	135618|Methylococcales	S	PFAM Type IV pilus assembly PilZ	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
k59_1857018_2	1123504.JQKD01000008_gene5405	8.33e-05	47.4	COG1360@1|root,COG3455@1|root,COG1360@2|Bacteria,COG3455@2|Bacteria,1MU13@1224|Proteobacteria,2VMB4@28216|Betaproteobacteria,4A9TK@80864|Comamonadaceae	28216|Betaproteobacteria	N	TIGRFAM type IV VI secretion system protein, DotU family	-	-	-	ko:K11892	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	DotU,OmpA
k59_1435050_1	390235.PputW619_0174	4.21e-63	207.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	glutamine synthetase	puuA	GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0034024,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575	6.3.1.11,6.3.1.2	ko:K01915,ko:K09470	ko00220,ko00250,ko00330,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	M00136	R00253,R07414	RC00010,RC00090,RC00096,RC02798	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iB21_1397.B21_01285,iECBD_1354.ECBD_2320,iECB_1328.ECB_01274,iECD_1391.ECD_01274,iSF_1195.SF1302	Gln-synt_C
k59_1857823_1	1454010.JEOE01000015_gene1112	4.69e-40	147.0	COG1207@1|root,COG1207@2|Bacteria,2GJS1@201174|Actinobacteria,4F0YE@85016|Cellulomonadaceae	201174|Actinobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030260,GO:0035635,GO:0040007,GO:0043167,GO:0043169,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
k59_1857823_2	471853.Bcav_0987	8.82e-28	108.0	COG0462@1|root,COG0462@2|Bacteria,2GJ9S@201174|Actinobacteria	201174|Actinobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_553341_1	1288826.MSNKSG1_04246	1.75e-141	423.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RPSW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Phosphoketolase	xfp	GO:0003674,GO:0003824,GO:0008150,GO:0009758	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
k59_1498866_1	204669.Acid345_2442	7.82e-39	150.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,3Y2ZI@57723|Acidobacteria,2JI9X@204432|Acidobacteriia	204432|Acidobacteriia	T	Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3,Reg_prop,Y_Y_Y
k59_1095982_2	1307759.JOMJ01000003_gene1584	3.7e-71	232.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,42NKK@68525|delta/epsilon subdivisions,2WIQQ@28221|Deltaproteobacteria,2MAPX@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_206824_1	1278309.KB907101_gene379	1.69e-16	84.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1XRT5@135619|Oceanospirillales	135619|Oceanospirillales	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_4,Response_reg
k59_927003_1	1167006.UWK_01356	3.4e-83	268.0	COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,42TR0@68525|delta/epsilon subdivisions,2WQ94@28221|Deltaproteobacteria,2MQ09@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Cellulose synthase	-	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Cellulose_synt,Glyco_hydro_8,Glyco_trans_2_3,Glycos_transf_2,PilZ
k59_1440174_1	179408.Osc7112_1981	6.63e-25	102.0	COG0596@1|root,COG0596@2|Bacteria,1G21Y@1117|Cyanobacteria,1H751@1150|Oscillatoriales	1117|Cyanobacteria	S	Belongs to the peptidase S33 family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
k59_1440174_2	1121921.KB898711_gene2048	8.43e-33	119.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria,2PN0I@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	F	Queuosine biosynthesis protein QueC	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
k59_1866596_1	1123257.AUFV01000005_gene1293	1.01e-46	155.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,1S60Z@1236|Gammaproteobacteria,1X61I@135614|Xanthomonadales	135614|Xanthomonadales	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,MafB19-deam,dCMP_cyt_deam_1
k59_1866596_2	1129374.AJE_00225	3.44e-59	196.0	COG0024@1|root,COG0024@2|Bacteria,1QXY6@1224|Proteobacteria,1T3K3@1236|Gammaproteobacteria,46DDB@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
k59_676562_1	338963.Pcar_2750	6.51e-82	251.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NTG@68525|delta/epsilon subdivisions,2WKHW@28221|Deltaproteobacteria,43UPV@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_676568_1	446471.Xcel_0179	2.87e-40	150.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria,4F3XN@85017|Promicromonosporaceae	201174|Actinobacteria	P	ABC-type Fe3 transport system permease component	thiP	-	-	ko:K02011,ko:K02063	ko02010,map02010	M00190,M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10,3.A.1.19	-	-	BPD_transp_1
k59_148271_1	454957.IA64_13370	4.41e-27	110.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1X486@135614|Xanthomonadales	135614|Xanthomonadales	I	3-hydroxyacyl-coa dehydrogenase	fadJ	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_148271_2	1255043.TVNIR_0881	2.05e-49	174.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales	135613|Chromatiales	I	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_47230_1	765913.ThidrDRAFT_0967	1.45e-17	80.9	COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,1S3T3@1236|Gammaproteobacteria,1WVZ9@135613|Chromatiales	135613|Chromatiales	S	subfamily IA, variant 1	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_47230_2	1276756.AUEX01000014_gene2870	6.92e-16	78.6	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2VH94@28216|Betaproteobacteria,4ABX3@80864|Comamonadaceae	28216|Betaproteobacteria	OU	peptidase S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_676577_1	159087.Daro_0490	6.94e-16	79.7	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2VHCR@28216|Betaproteobacteria,2KVDS@206389|Rhodocyclales	206389|Rhodocyclales	S	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_1270346_2	767434.Fraau_0489	1.26e-41	150.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1X4GI@135614|Xanthomonadales	135614|Xanthomonadales	M	transferase	waaA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N
k59_105119_1	279714.FuraDRAFT_2536	4.26e-69	221.0	COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,2WHDP@28216|Betaproteobacteria,2KTX4@206351|Neisseriales	206351|Neisseriales	V	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_1866627_1	1049564.TevJSym_ad00260	3.68e-122	363.0	COG1008@1|root,COG1008@2|Bacteria,1R8V8@1224|Proteobacteria,1RZVG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	overlaps another CDS with the same product name	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1142165_1	1147.D082_20570	3.58e-103	307.0	COG3588@1|root,COG3588@2|Bacteria,1GIGU@1117|Cyanobacteria,1H6CK@1142|Synechocystis	1117|Cyanobacteria	F	Fructose-bisphosphate aldolase class-I	-	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
k59_1142165_2	745411.B3C1_00560	2.02e-31	117.0	COG1416@1|root,COG1416@2|Bacteria,1RI2V@1224|Proteobacteria,1S1W9@1236|Gammaproteobacteria,1J6UE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
k59_499903_2	590998.Celf_3212	6.64e-26	105.0	COG1819@1|root,COG1819@2|Bacteria	2|Bacteria	CG	transferase activity, transferring hexosyl groups	alg2	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,UDPGT
k59_986186_1	880072.Desac_1463	1.36e-97	317.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2MR0B@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_558457_1	1265313.HRUBRA_02126	2.99e-23	103.0	COG4774@1|root,COG4774@2|Bacteria,1RBVQ@1224|Proteobacteria,1SMVM@1236|Gammaproteobacteria,1J8EM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	Plug
k59_1096037_1	1163409.UUA_11503	3.66e-45	163.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RR1B@1236|Gammaproteobacteria,1X443@135614|Xanthomonadales	135614|Xanthomonadales	L	Helicase	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_47267_1	1163617.SCD_n02931	1.67e-65	213.0	COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,2VS6Y@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative metallopeptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2201,DUF2201_N
k59_441856_1	1304883.KI912532_gene2178	5.71e-40	147.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2VHQS@28216|Betaproteobacteria,2KVUJ@206389|Rhodocyclales	206389|Rhodocyclales	K	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_4,Sigma54_activat
k59_399686_1	1267005.KB911257_gene1094	1.25e-91	293.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,3N67P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1556648_1	1121405.dsmv_0948	4.74e-112	361.0	COG0764@1|root,COG3321@1|root,COG0764@2|Bacteria,COG3321@2|Bacteria,1QUWM@1224|Proteobacteria,43BRB@68525|delta/epsilon subdivisions,2WJJ6@28221|Deltaproteobacteria,2MI1Q@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Acyltransferase,FabA,KAsynt_C_assoc,Ketoacyl-synt_C,PS-DH,ketoacyl-synt
k59_987193_1	471853.Bcav_1418	1.18e-89	273.0	COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria	201174|Actinobacteria	E	Branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_1024167_1	1249627.D779_3936	2.11e-64	200.0	COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,1S263@1236|Gammaproteobacteria,1WX7S@135613|Chromatiales	135613|Chromatiales	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	tpx	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
k59_148951_1	326427.Cagg_3632	2.44e-42	149.0	COG0861@1|root,COG0861@2|Bacteria,2G66P@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Integral membrane protein TerC	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
k59_1142735_1	1292020.H483_0117010	6.39e-13	69.3	COG1004@1|root,COG1004@2|Bacteria,2GJQB@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	udgA	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_1142735_2	671143.DAMO_2784	1.14e-06	49.3	COG0451@1|root,COG0451@2|Bacteria,2NP15@2323|unclassified Bacteria	2|Bacteria	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	rfbB	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678	ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00793	R01384,R06513	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_1205720_1	933262.AXAM01000014_gene231	2.3e-80	245.0	COG2159@1|root,COG2159@2|Bacteria,1RJPH@1224|Proteobacteria,42T4E@68525|delta/epsilon subdivisions,2WPSE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_559125_1	1366050.N234_12650	6.92e-19	80.1	COG3293@1|root,COG3293@2|Bacteria,1RAWR@1224|Proteobacteria,2VTFP@28216|Betaproteobacteria,1K8M2@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_559125_2	391735.Veis_4715	1.78e-36	127.0	COG3293@1|root,COG3293@2|Bacteria,1N13W@1224|Proteobacteria,2VUET@28216|Betaproteobacteria,4AK02@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2
k59_1614884_1	290340.AAur_2012	4.03e-59	186.0	COG0251@1|root,COG0251@2|Bacteria,2IKQ2@201174|Actinobacteria	201174|Actinobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_441866_1	530564.Psta_2657	6.33e-80	265.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,2IY13@203682|Planctomycetes	203682|Planctomycetes	E	Putative amidoligase enzyme (DUF2126)	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
k59_559129_1	1278073.MYSTI_06363	5.81e-22	99.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YTY9@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_987213_1	323850.Shew_3240	2.28e-47	160.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	response regulator	nodW	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_987213_2	378806.STAUR_1171	2.44e-07	52.0	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2X791@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_106197_1	1198232.CYCME_1689	3.55e-153	438.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,1RMR8@1236|Gammaproteobacteria,4627G@72273|Thiotrichales	72273|Thiotrichales	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
k59_789262_1	553207.HMPREF0299_5033	4.59e-136	394.0	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria,22MAC@1653|Corynebacteriaceae	201174|Actinobacteria	E	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases	adh	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1614896_1	1384056.N787_03790	1.4e-24	97.4	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	pspE	GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005623,GO:0016740,GO:0016782,GO:0016783,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	-	ko:K03972	-	-	-	-	ko00000	-	-	iE2348C_1286.E2348C_1500,iECABU_c1320.ECABU_c15910,iSDY_1059.SDY_1936,ic_1306.c1779	Rhodanese
k59_1614896_2	419610.Mext_4320	7.66e-15	70.1	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2U956@28211|Alphaproteobacteria,1JUJ9@119045|Methylobacteriaceae	28211|Alphaproteobacteria	FG	PFAM histidine triad (HIT) protein	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
k59_987222_1	1254432.SCE1572_23885	9.23e-33	134.0	COG3507@1|root,COG3507@2|Bacteria,1R3V6@1224|Proteobacteria,43A5N@68525|delta/epsilon subdivisions,2X50Q@28221|Deltaproteobacteria,2YZY6@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.99	ko:K06113	-	-	-	-	ko00000,ko01000	-	GH43	-	Glyco_hydro_43
k59_1096784_1	1249627.D779_3523	2.04e-57	199.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,1WWT6@135613|Chromatiales	135613|Chromatiales	M	Surface antigen variable number	-	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,POTRA_TamA_1
k59_1142758_1	317025.Tcr_0286	1.54e-12	65.5	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,460IU@72273|Thiotrichales	72273|Thiotrichales	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_617750_1	1550073.JROH01000036_gene2672	2.96e-12	67.0	COG0517@1|root,COG0517@2|Bacteria,1QVXV@1224|Proteobacteria,2U5IK@28211|Alphaproteobacteria,2KD88@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_1733116_1	765913.ThidrDRAFT_0481	2.2e-98	298.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,1WVYS@135613|Chromatiales	135613|Chromatiales	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
k59_48426_1	471870.BACINT_00344	6.31e-99	314.0	COG3507@1|root,COG3589@1|root,COG3507@2|Bacteria,COG3589@2|Bacteria,4NE7B@976|Bacteroidetes,2FM4U@200643|Bacteroidia,4AMZV@815|Bacteroidaceae	976|Bacteroidetes	G	COG NOG26813 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	GH97_C,GH97_N,Glyco_hydro_97
k59_735913_2	706587.Desti_0156	9.17e-26	107.0	COG2605@1|root,COG2605@2|Bacteria,1Q1GI@1224|Proteobacteria,42TJZ@68525|delta/epsilon subdivisions,2WQNP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	GHMP kinases N terminal domain	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_1790083_1	926569.ANT_08370	1.18e-56	181.0	COG1143@1|root,COG1143@2|Bacteria,2G6P8@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338,ko:K05580	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
k59_1556689_1	1218075.BAYA01000004_gene1503	5.88e-66	210.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,1K3JW@119060|Burkholderiaceae	28216|Betaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1271224_1	349124.Hhal_0217	3.96e-38	134.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins	iscR	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
k59_106247_1	1304885.AUEY01000030_gene2424	1.63e-37	140.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,42M4X@68525|delta/epsilon subdivisions,2WJJY@28221|Deltaproteobacteria,2MI3C@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
k59_1205754_2	314345.SPV1_08071	1.38e-58	193.0	COG1985@1|root,COG1985@2|Bacteria,1RDMT@1224|Proteobacteria	1224|Proteobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_48453_1	1219375.CM002139_gene3889	3.81e-05	46.6	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1X3SW@135614|Xanthomonadales	135614|Xanthomonadales	C	NADH ubiquinone oxidoreductase subunit	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_48453_2	640081.Dsui_3039	1.73e-38	144.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,2KUJW@206389|Rhodocyclales	206389|Rhodocyclales	CP	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_928169_1	1128421.JAGA01000002_gene1343	3.61e-116	340.0	COG5640@1|root,COG5640@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin
k59_149001_1	765912.Thimo_2911	4.28e-167	479.0	COG1449@1|root,COG1449@2|Bacteria,1R3Z3@1224|Proteobacteria,1RNRC@1236|Gammaproteobacteria,1WVY7@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_1096817_1	446466.Cfla_2721	3.38e-42	153.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4F0T7@85016|Cellulomonadaceae	201174|Actinobacteria	O	PFAM peptidase S1 and S6 chymotrypsin Hap	degP	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
k59_789293_1	1249627.D779_2987	1.24e-65	208.0	COG4798@1|root,COG4798@2|Bacteria,1QUNP@1224|Proteobacteria,1S3N0@1236|Gammaproteobacteria,1WYE0@135613|Chromatiales	135613|Chromatiales	S	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1505594_1	1189612.A33Q_0076	6.14e-24	102.0	COG0452@1|root,COG0452@2|Bacteria,4NE46@976|Bacteroidetes,47MHR@768503|Cytophagia	976|Bacteroidetes	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k59_1614933_1	983545.Glaag_1591	1.28e-60	194.0	COG0346@1|root,COG0346@2|Bacteria,1N1JV@1224|Proteobacteria,1SMP5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_677309_1	279714.FuraDRAFT_1514	2.46e-53	186.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2VJ2F@28216|Betaproteobacteria,2KQ33@206351|Neisseriales	206351|Neisseriales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
k59_677309_2	543913.D521_0425	4.7e-30	117.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2VJ2F@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narG	-	1.7.5.1	ko:K00370,ko:K17050	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
k59_48466_1	953739.SVEN_4379	1.92e-13	67.4	COG0087@1|root,COG0087@2|Bacteria,2GJXT@201174|Actinobacteria	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_48466_2	981369.JQMJ01000004_gene3188	6.86e-68	205.0	COG0051@1|root,COG0051@2|Bacteria,2IHRA@201174|Actinobacteria,2NIMG@228398|Streptacidiphilus	201174|Actinobacteria	J	Ribosomal protein S10p/S20e	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
k59_623845_1	1279017.AQYJ01000029_gene3823	1.96e-152	441.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,464G4@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
k59_331115_1	717785.HYPMC_2544	3.18e-85	265.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2TQVF@28211|Alphaproteobacteria,3N63R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	MgsA AAA+ ATPase C terminal	rarA	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_858712_1	247634.GPB2148_721	2.42e-24	93.2	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,1S8UG@1236|Gammaproteobacteria,1J6PJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
k59_858712_3	1499686.BN1079_02112	1.22e-26	105.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_1681696_1	266940.Krad_3278	4.38e-28	111.0	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1681696_2	367299.JOEE01000004_gene1414	8.13e-41	136.0	2E6TR@1|root,331DK@2|Bacteria,2IQF8@201174|Actinobacteria,4FHWF@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1681696_3	1385519.N801_09585	4.36e-37	137.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4FEMJ@85021|Intrasporangiaceae	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_331122_1	367299.JOEE01000004_gene1040	8.05e-131	390.0	COG0366@1|root,COG0366@2|Bacteria,2GJKR@201174|Actinobacteria,4FEI1@85021|Intrasporangiaceae	201174|Actinobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_565274_1	177437.HRM2_22850	1.01e-73	240.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2MIU8@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_331123_1	1385519.N801_10420	1.67e-99	318.0	COG0479@1|root,COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0479@2|Bacteria,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2I995@201174|Actinobacteria,4FITA@85021|Intrasporangiaceae	201174|Actinobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1277973_1	1232437.KL662015_gene1255	2.71e-06	55.5	COG2909@1|root,COG3187@1|root,COG2909@2|Bacteria,COG3187@2|Bacteria	2|Bacteria	O	response to heat	-	-	-	ko:K03668,ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	GerE,META
k59_506711_1	626887.J057_04185	5.58e-49	160.0	COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,1S8WT@1236|Gammaproteobacteria,467R0@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG2969 Stringent starvation protein B	sspB	GO:0000502,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0009376,GO:0009893,GO:0009894,GO:0009896,GO:0010604,GO:0019222,GO:0019899,GO:0031597,GO:0032781,GO:0032991,GO:0042176,GO:0042802,GO:0042803,GO:0043085,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043462,GO:0044093,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045732,GO:0046983,GO:0048518,GO:0050789,GO:0050790,GO:0051117,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051336,GO:0051345,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:1901363,GO:1902494,GO:1904949,GO:1905368,GO:1905369,GO:1990904	-	ko:K03600	-	-	-	-	ko00000,ko03021	-	-	-	SspB
k59_506711_2	870187.Thini_1049	4.36e-68	212.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria,460HZ@72273|Thiotrichales	72273|Thiotrichales	O	Stringent starvation protein A	-	-	-	ko:K03599	-	-	-	-	ko00000,ko02000,ko03021	1.A.12.3.1	-	-	GST_C,GST_N_3
k59_56783_1	1499967.BAYZ01000006_gene5459	6.4e-74	234.0	COG0444@1|root,COG0444@2|Bacteria	2|Bacteria	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1030615_1	264732.Moth_0402	3.59e-23	95.1	COG2050@1|root,COG2050@2|Bacteria,1VFHF@1239|Firmicutes,24QNY@186801|Clostridia,42H63@68295|Thermoanaerobacterales	186801|Clostridia	Q	Thioesterase superfamily	-	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
k59_408945_1	991905.SL003B_3397	1.06e-117	350.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,4BP7R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_1681707_2	999541.bgla_1g24150	8.65e-57	199.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,1K06P@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_331134_1	1232410.KI421424_gene1680	6.14e-48	165.0	COG1363@1|root,COG1363@2|Bacteria,1MXEU@1224|Proteobacteria,42P13@68525|delta/epsilon subdivisions,2WMM6@28221|Deltaproteobacteria,43TD3@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
k59_1030619_1	555778.Hneap_0120	2.51e-181	521.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1WVY6@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
k59_331136_1	1122951.ATUE01000006_gene940	1.19e-43	160.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,3NJIZ@468|Moraxellaceae	1236|Gammaproteobacteria	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_4,DNA_pol3_tau_5
k59_1877061_1	1298867.AUES01000051_gene4511	3.34e-21	99.0	COG0771@1|root,COG2931@1|root,COG4625@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K2H3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,HemolysinCabind
k59_1562812_1	909613.UO65_0334	2.19e-69	235.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria,4EEFW@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_565301_1	857087.Metme_1888	2.85e-94	303.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XDW6@135618|Methylococcales	135618|Methylococcales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1739414_1	631362.Thi970DRAFT_02476	2.24e-116	346.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1WXB6@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_1562814_1	56780.SYN_02261	2.7e-45	166.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2WJ3W@28221|Deltaproteobacteria,2MR18@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_155364_1	246197.MXAN_3779	7.34e-39	148.0	COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1MU6G@1224|Proteobacteria	1224|Proteobacteria	IQ	COG0318, Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Bac_luciferase,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,Methyltransf_25,PP-binding,Thioesterase,ketoacyl-synt
k59_996321_1	794903.OPIT5_07355	2.24e-37	142.0	COG1530@1|root,COG1530@2|Bacteria,46S5S@74201|Verrucomicrobia,3K7UA@414999|Opitutae	414999|Opitutae	J	Ribonuclease E/G family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
k59_742289_1	1123392.AQWL01000009_gene1115	1.81e-63	206.0	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,2VR2T@28216|Betaproteobacteria	28216|Betaproteobacteria	H	PUA-like domain	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PK,PUA_2
k59_1030633_1	1158292.JPOE01000002_gene3140	5.28e-39	145.0	COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,2VQEZ@28216|Betaproteobacteria,1KK13@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1103514_1	857087.Metme_0438	2.44e-27	115.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN5K@1236|Gammaproteobacteria,1XETH@135618|Methylococcales	135618|Methylococcales	MU	PFAM Outer membrane efflux protein	-	-	-	ko:K18300	-	M00641	-	-	ko00000,ko00002,ko01504,ko02000	1.B.17	-	-	OEP
k59_565318_1	335543.Sfum_1977	1.89e-83	273.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MQTI@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
k59_331167_1	582899.Hden_0682	4.32e-31	114.0	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,2UFSY@28211|Alphaproteobacteria,3N791@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	PFAM regulatory protein ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
k59_1278018_1	96561.Dole_0660	2.33e-23	103.0	COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,42S7X@68525|delta/epsilon subdivisions,2WNJ2@28221|Deltaproteobacteria,2MJG4@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_115490_1	765913.ThidrDRAFT_0056	8.27e-68	218.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RMCS@1236|Gammaproteobacteria,1WWP0@135613|Chromatiales	135613|Chromatiales	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.98	ko:K13017	ko00520,map00520	-	R10141	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
k59_623912_1	754476.Q7A_2823	9.4e-72	227.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,45ZSV@72273|Thiotrichales	72273|Thiotrichales	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_1030660_1	865937.Gilli_2218	1.89e-14	73.9	COG2020@1|root,COG2020@2|Bacteria,4NTAC@976|Bacteroidetes,1I4A9@117743|Flavobacteriia,2P7KZ@244698|Gillisia	976|Bacteroidetes	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_409050_1	452637.Oter_2447	2.26e-16	79.3	COG1704@1|root,COG1704@2|Bacteria	2|Bacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	GIDE,LemA
k59_1621024_2	754436.JCM19237_3500	1.07e-40	139.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,1S3QE@1236|Gammaproteobacteria,1XXB1@135623|Vibrionales	135623|Vibrionales	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	hinT	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
k59_1621024_3	1173021.ALWA01000036_gene3592	2.34e-20	87.8	2E6Y4@1|root,331HE@2|Bacteria,1GE1Z@1117|Cyanobacteria	1117|Cyanobacteria	S	MerC mercury resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MerC
k59_858778_1	243233.MCA2283	1.38e-47	167.0	COG0439@1|root,COG0439@2|Bacteria,1NHC0@1224|Proteobacteria	1224|Proteobacteria	I	Biotin carboxylase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1387057_1	1033802.SSPSH_001221	3.67e-95	282.0	COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis	rnt	GO:0000287,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360	-	ko:K03683	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_T
k59_1682468_1	1304865.JAGF01000001_gene2721	1.92e-22	90.5	COG0355@1|root,COG0355@2|Bacteria,2IHNZ@201174|Actinobacteria,4F2TB@85016|Cellulomonadaceae	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
k59_1682468_2	266940.Krad_1272	1.46e-08	56.6	2E6YX@1|root,331I5@2|Bacteria,2IFIG@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF2550)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2550
k59_997466_2	446466.Cfla_1858	3.31e-58	193.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2GKAX@201174|Actinobacteria,4F0EI@85016|Cellulomonadaceae	201174|Actinobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_507506_1	395961.Cyan7425_1960	5.99e-56	187.0	COG0297@1|root,COG0297@2|Bacteria,1G1YU@1117|Cyanobacteria,3KG2S@43988|Cyanothece	1117|Cyanobacteria	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA2	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_507506_2	765912.Thimo_2911	3.49e-28	112.0	COG1449@1|root,COG1449@2|Bacteria,1R3Z3@1224|Proteobacteria,1RNRC@1236|Gammaproteobacteria,1WVY7@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_57858_1	652103.Rpdx1_4897	8.7e-80	263.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria,3JSD0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2
k59_1104376_1	1122933.JNIY01000003_gene918	1.08e-79	243.0	COG0689@1|root,COG0689@2|Bacteria,2GJFI@201174|Actinobacteria,4F0NJ@85016|Cellulomonadaceae	201174|Actinobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
k59_1031423_1	930166.CD58_26965	2.06e-41	149.0	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,1RQ1Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	phosphotransferase related to Ser Thr protein kinases	-	GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
k59_684394_1	1123256.KB907933_gene2235	6.69e-27	107.0	2C8PG@1|root,32RMK@2|Bacteria,1N0UQ@1224|Proteobacteria,1SBBP@1236|Gammaproteobacteria,1X8WF@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_684394_2	1248760.ANFZ01000012_gene20	2.64e-134	394.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TTRS@28211|Alphaproteobacteria,2K3E6@204457|Sphingomonadales	204457|Sphingomonadales	E	dehydratase, large subunit	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_116555_1	1068978.AMETH_3058	1.07e-94	291.0	2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria,4E2VY@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
k59_116555_2	479432.Sros_1213	3.71e-13	72.0	COG0702@1|root,COG0702@2|Bacteria,2HBFK@201174|Actinobacteria,4EGAC@85012|Streptosporangiales	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
k59_1387761_1	179408.Osc7112_3277	8.01e-12	63.2	COG3744@1|root,COG3744@2|Bacteria,1G6ZS@1117|Cyanobacteria,1HBK3@1150|Oscillatoriales	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
k59_1387761_2	1125863.JAFN01000001_gene2240	1.78e-14	68.9	COG4118@1|root,COG4118@2|Bacteria,1N7BG@1224|Proteobacteria,42W6P@68525|delta/epsilon subdivisions,2WS1F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
k59_1682492_1	1170562.Cal6303_5132	1.93e-20	91.7	COG3968@1|root,COG3968@2|Bacteria,1G0CH@1117|Cyanobacteria	1117|Cyanobacteria	S	Glutamine synthetase type III	glnN	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
k59_938252_1	1267005.KB911257_gene1077	1.95e-31	125.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,3N63N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Alpha-2-Macroglobulin	MA20_30110	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,PAN_1,Thiol-ester_cl
k59_410133_2	321955.AAGP01000046_gene3798	2.34e-37	140.0	COG2035@1|root,COG2035@2|Bacteria,2I8HU@201174|Actinobacteria,4F9NW@85019|Brevibacteriaceae	201174|Actinobacteria	S	Domain of unknown function (DUF368)	-	-	-	ko:K08974	-	-	-	-	ko00000	-	-	-	DUF368
k59_938258_1	118161.KB235922_gene4668	3.52e-79	249.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	3.5.1.53,6.3.5.1	ko:K01950,ko:K12251	ko00330,ko00760,ko01100,map00330,map00760,map01100	M00115	R00257,R01152	RC00010,RC00096,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
k59_331965_2	393595.ABO_1529	7.67e-91	279.0	COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,1RN9B@1236|Gammaproteobacteria,1XID3@135619|Oceanospirillales	135619|Oceanospirillales	C	carnitine dehydratase	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
k59_410140_2	1203605.HMPREF1531_00014	1.01e-75	247.0	COG1215@1|root,COG1215@2|Bacteria,2INXB@201174|Actinobacteria,4DRCH@85009|Propionibacteriales	201174|Actinobacteria	M	Glycosyl transferase family group 2	-	-	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
k59_1621748_2	765911.Thivi_2696	9.62e-40	138.0	2AB8D@1|root,310NU@2|Bacteria,1RFGC@1224|Proteobacteria,1S5A2@1236|Gammaproteobacteria,1WYCR@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_290537_1	1249627.D779_1104	5.16e-93	284.0	COG0247@1|root,COG1145@1|root,COG0247@2|Bacteria,COG1145@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1WWK6@135613|Chromatiales	135613|Chromatiales	C	PFAM Cysteine-rich	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_624704_1	1121920.AUAU01000006_gene293	1.82e-91	298.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,3Y3BP@57723|Acidobacteria	57723|Acidobacteria	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_1513057_1	1479623.JHEL01000015_gene708	1.42e-126	389.0	COG0553@1|root,COG0553@2|Bacteria,2GM2V@201174|Actinobacteria,4FPG2@85023|Microbacteriaceae	201174|Actinobacteria	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,PLDc_2,SNF2_N
k59_1447512_1	331869.BAL199_08768	2.29e-25	103.0	COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria,2TVQ7@28211|Alphaproteobacteria,4BR8P@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	4-hydroxyphenylacetate 3-hydroxylase C terminal	-	-	1.14.14.9	ko:K00483	ko00350,ko01120,ko01220,map00350,map01120,map01220	-	R02698,R03299	RC00046	ko00000,ko00001,ko01000	-	-	-	HpaB,HpaB_N
k59_1447512_2	371731.Rsw2DRAFT_1960	0.000586	42.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSG6@28211|Alphaproteobacteria,1FBEA@1060|Rhodobacter	28211|Alphaproteobacteria	C	PFAM FAD linked oxidase domain protein	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_57914_1	134676.ACPL_5533	6.62e-12	72.8	COG0477@1|root,COG2814@2|Bacteria,2H4H5@201174|Actinobacteria,4D9KH@85008|Micromonosporales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	ko:K05557	-	-	-	-	ko00000,ko02000	2.A.1.3.7	-	-	MFS_1
k59_448845_1	598659.NAMH_0714	2.14e-160	468.0	COG0074@1|root,COG0372@1|root,COG0074@2|Bacteria,COG0372@2|Bacteria,1MUGA@1224|Proteobacteria,42NI0@68525|delta/epsilon subdivisions,2YNKI@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	ATP citrate synthase	-	-	2.3.3.8	ko:K15230	ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200	M00173	R00352	RC00004,RC00067	ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt,Ligase_CoA
k59_1682514_1	765912.Thimo_0154	1.15e-87	271.0	COG5557@1|root,COG5557@2|Bacteria,1MXP7@1224|Proteobacteria,1RS7Z@1236|Gammaproteobacteria,1WX2A@135613|Chromatiales	135613|Chromatiales	C	PFAM Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_1682514_2	648757.Rvan_0590	5.59e-18	80.9	COG0437@1|root,COG0437@2|Bacteria,1QUMM@1224|Proteobacteria	1224|Proteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	ko:K00184,ko:K08358	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10150	RC03109	ko00000,ko00001,ko02000	5.A.3,5.A.3.10	-	-	Fer4_11,Fer4_3,Fer4_4,Fer4_6,Fer4_7
k59_1740258_1	485913.Krac_8354	1.77e-66	215.0	COG0484@1|root,COG0484@2|Bacteria,2G5NV@200795|Chloroflexi	200795|Chloroflexi	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_116589_1	471853.Bcav_1810	1.92e-36	137.0	COG2609@1|root,COG2609@2|Bacteria,2GJRE@201174|Actinobacteria	201174|Actinobacteria	C	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0004739,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016624,GO:0016903,GO:0030312,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046872,GO:0055114,GO:0071944,GO:1902494,GO:1990204	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_1387784_1	344747.PM8797T_11831	7.64e-87	266.0	COG0673@1|root,COG0673@2|Bacteria,2IZC8@203682|Planctomycetes	203682|Planctomycetes	C	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_331974_1	187272.Mlg_1350	1.56e-96	288.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,1WXFG@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
k59_331974_2	314278.NB231_01154	9.57e-64	206.0	COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,1WY02@135613|Chromatiales	135613|Chromatiales	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
k59_331974_3	697282.Mettu_1134	5.04e-09	56.6	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,1XE7Q@135618|Methylococcales	135618|Methylococcales	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
k59_800189_2	697303.Thewi_2114	1.73e-10	61.2	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
k59_750277_1	153948.NAL212_0250	1.49e-25	107.0	COG3677@1|root,COG3677@2|Bacteria,1R3ZS@1224|Proteobacteria,2WFCR@28216|Betaproteobacteria	1224|Proteobacteria	L	Transposase zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_1039557_1	1089552.KI911559_gene3224	4.33e-79	243.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2TR4Y@28211|Alphaproteobacteria,2JPJR@204441|Rhodospirillales	204441|Rhodospirillales	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
k59_572900_1	926566.Terro_0874	9.08e-10	58.5	COG0476@1|root,COG0607@1|root,COG1977@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,COG1977@2|Bacteria,3Y3IF@57723|Acidobacteria,2JIPC@204432|Acidobacteriia	204432|Acidobacteriia	HP	PFAM UBA THIF-type NAD FAD binding	-	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF,ThiS
k59_572900_2	401053.AciPR4_3470	3.72e-17	82.8	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,3Y3IF@57723|Acidobacteria,2JIPC@204432|Acidobacteriia	204432|Acidobacteriia	HP	PFAM UBA THIF-type NAD FAD binding	-	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF,ThiS
k59_800194_1	519989.ECTPHS_04329	1.6e-71	228.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1WXA3@135613|Chromatiales	135613|Chromatiales	U	General secretion pathway protein F	-	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
k59_691276_1	1120949.KB903307_gene1321	3.5e-36	130.0	28JRZ@1|root,2Z9HI@2|Bacteria,2H9EF@201174|Actinobacteria,4DD50@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
k59_1396245_3	631362.Thi970DRAFT_04680	3.52e-07	48.9	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,1S8XZ@1236|Gammaproteobacteria,1WYM5@135613|Chromatiales	135613|Chromatiales	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_751690_1	1530186.JQEY01000001_gene1326	1.16e-49	169.0	COG1910@1|root,COG1910@2|Bacteria,1MVS4@1224|Proteobacteria,2TU96@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG1910, Periplasmic molybdate-binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,PBP_like
k59_1748728_1	1085623.GNIT_3422	3.81e-72	238.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,4656T@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG2217 Cation transport ATPase	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_868956_1	396588.Tgr7_0584	4.16e-88	271.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RNPY@1236|Gammaproteobacteria,1WWN2@135613|Chromatiales	135613|Chromatiales	O	PFAM peptidase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
k59_515202_2	1249627.D779_0603	4.25e-76	246.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RNES@1236|Gammaproteobacteria,1X2HE@135613|Chromatiales	135613|Chromatiales	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1396255_1	765914.ThisiDRAFT_0219	1.29e-130	374.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,1WX9I@135613|Chromatiales	135613|Chromatiales	G	Belongs to the ribulose-phosphate 3-epimerase family	-	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_1630590_1	395494.Galf_1734	2.48e-87	264.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2VJ13@28216|Betaproteobacteria,44V7C@713636|Nitrosomonadales	28216|Betaproteobacteria	I	Squalene/phytoene synthase	hpnD	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
k59_1572437_1	522306.CAP2UW1_3650	3.47e-76	243.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2VPV5@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1456618_1	83406.HDN1F_22190	3.44e-09	62.8	COG4733@1|root,COG4733@2|Bacteria,1R55I@1224|Proteobacteria,1S5X2@1236|Gammaproteobacteria,1JB4V@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1114899_2	713586.KB900536_gene38	9.54e-11	61.2	COG2930@1|root,COG2930@2|Bacteria,1RCYH@1224|Proteobacteria,1S41U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Las17-binding protein actin regulator	CT2216	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_692505_1	105425.BBPL01000006_gene7195	3.26e-76	243.0	COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria,2NEZ8@228398|Streptacidiphilus	201174|Actinobacteria	J	tRNA synthetases class I (E and Q), catalytic domain	gltX	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	iNJ661.Rv2992c	tRNA-synt_1c
k59_340719_1	367299.JOEE01000008_gene606	1.44e-97	289.0	COG0805@1|root,COG0805@2|Bacteria,2GJK8@201174|Actinobacteria,4FF5V@85021|Intrasporangiaceae	201174|Actinobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_573989_1	1089455.MOPEL_135_02120	3.93e-81	258.0	COG1397@1|root,COG1397@2|Bacteria	2|Bacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH,DSPc
k59_1041353_1	1266925.JHVX01000003_gene560	2.33e-11	73.6	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,3727Q@32003|Nitrosomonadales	28216|Betaproteobacteria	L	UvrD REP	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1748741_1	1429046.RR21198_5289	2.74e-12	71.6	2D2AG@1|root,32TCD@2|Bacteria,2IARE@201174|Actinobacteria,4FWEI@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1114912_1	765912.Thimo_2584	9.39e-79	259.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1WX68@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1630604_1	1236959.BAMT01000002_gene2110	2.55e-28	110.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,2KKH8@206350|Nitrosomonadales	206350|Nitrosomonadales	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_1630604_2	745411.B3C1_05622	4.68e-34	129.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,1J4XV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M17
k59_573999_1	396588.Tgr7_2661	6.85e-37	141.0	COG0651@1|root,COG0651@2|Bacteria,1N6BY@1224|Proteobacteria,1RR4C@1236|Gammaproteobacteria,1WWFY@135613|Chromatiales	135613|Chromatiales	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_1691552_1	1120941.AUBL01000009_gene795	3.5e-38	142.0	COG0213@1|root,COG0295@1|root,COG0213@2|Bacteria,COG0295@2|Bacteria,2GJH5@201174|Actinobacteria,4D329@85005|Actinomycetales	201174|Actinobacteria	F	phosphorylase	deoA	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
k59_1691552_2	1449346.JQMO01000003_gene5251	3.39e-60	189.0	COG0295@1|root,COG0295@2|Bacteria,2IHP7@201174|Actinobacteria,2M2V4@2063|Kitasatospora	201174|Actinobacteria	F	Cytidine and deoxycytidylate deaminase zinc-binding region	cdd	GO:0003674,GO:0003824,GO:0004126,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006213,GO:0006216,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008655,GO:0009056,GO:0009058,GO:0009112,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009972,GO:0009987,GO:0016020,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019856,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042455,GO:0043094,GO:0043100,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046087,GO:0046108,GO:0046109,GO:0046112,GO:0046131,GO:0046132,GO:0046133,GO:0046134,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0047844,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0072529,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1,dCMP_cyt_deam_2
k59_1523737_1	1191523.MROS_2798	2.21e-121	378.0	COG0574@1|root,COG0574@2|Bacteria	2|Bacteria	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_2,PPDK_N,Response_reg
k59_340731_1	525268.HMPREF0308_1539	1.01e-19	84.3	COG0802@1|root,COG0802@2|Bacteria,2IKV2@201174|Actinobacteria,22N8N@1653|Corynebacteriaceae	201174|Actinobacteria	S	ATPase or kinase	tsaE	GO:0008150,GO:0040007	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
k59_340731_2	561175.KB894099_gene5076	1.29e-26	110.0	COG2267@1|root,COG2267@2|Bacteria,2GMCK@201174|Actinobacteria,4EFMQ@85012|Streptosporangiales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
k59_1041375_1	301.JNHE01000001_gene290	4.73e-34	133.0	COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,1YF2D@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	LppC putative lipoprotein	lpoA	GO:0000270,GO:0003674,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	-	ko:K07121	-	-	-	-	ko00000	-	-	-	LppC
k59_1114924_1	1380390.JIAT01000009_gene2035	4.95e-101	308.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4CP8M@84995|Rubrobacteria	84995|Rubrobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_574004_1	44060.JODL01000004_gene2468	1.31e-84	264.0	COG1168@1|root,COG1168@2|Bacteria,2GJFQ@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase, class I	patB	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1289701_1	1123401.JHYQ01000022_gene1146	4.26e-101	315.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,461P1@72273|Thiotrichales	72273|Thiotrichales	F	5'-nucleotidase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,Metallophos
k59_868997_1	866536.Belba_1743	8.47e-46	164.0	COG0265@1|root,COG0265@2|Bacteria,4NFCS@976|Bacteroidetes,47KF5@768503|Cytophagia	976|Bacteroidetes	O	PDZ domain (Also known as DHR or GLGF)	htrA	-	-	-	-	-	-	-	-	-	-	-	PDZ_1,PDZ_2,Trypsin_2
k59_164745_1	69395.JQLZ01000004_gene800	7.19e-47	173.0	COG1629@1|root,COG4771@2|Bacteria,1PSM0@1224|Proteobacteria,2U3MX@28211|Alphaproteobacteria,2KHTG@204458|Caulobacterales	204458|Caulobacterales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
k59_1523755_1	118163.Ple7327_1613	6.68e-31	122.0	COG0778@1|root,COG0778@2|Bacteria,1GQ2U@1117|Cyanobacteria	1117|Cyanobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_574007_1	768671.ThimaDRAFT_3547	8e-130	387.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,1S124@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	BT1 family	-	-	-	-	-	-	-	-	-	-	-	-	BT1
k59_801117_1	1122132.AQYH01000008_gene2710	8.74e-70	237.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,2U3GJ@28211|Alphaproteobacteria,4BNPE@82115|Rhizobiaceae	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_1456659_1	396588.Tgr7_2406	7.32e-40	149.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1WX4H@135613|Chromatiales	135613|Chromatiales	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	OapA,Peptidase_M23
k59_515232_1	565045.NOR51B_1268	9.02e-31	120.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0003674,GO:0003824,GO:0003887,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_515232_2	95619.PM1_0213410	2.77e-22	97.8	COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,1S28B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	nucleotidyltransferase DNA polymerase involved in DNA repair	imuB	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
k59_222920_1	443143.GM18_0341	2.84e-78	257.0	COG2133@1|root,COG2133@2|Bacteria,1NRFC@1224|Proteobacteria,42YAV@68525|delta/epsilon subdivisions,2WTUF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_751766_1	706587.Desti_4664	9.16e-54	184.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42R6X@68525|delta/epsilon subdivisions,2WMY9@28221|Deltaproteobacteria,2MSBC@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1630645_1	384765.SIAM614_01936	4.01e-30	117.0	COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1R4UA@1224|Proteobacteria,2TTQ6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Oxidoreductase FAD NAD(P)-binding domain protein	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
k59_1630645_2	1211115.ALIQ01000089_gene4454	1.71e-37	138.0	COG2864@1|root,COG2864@2|Bacteria,1R5NK@1224|Proteobacteria,2U2HQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Ethylbenzene dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh,Ni_hydr_CYTB
k59_515234_1	96561.Dole_1171	1.98e-87	285.0	COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2MIS3@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1041417_1	1265505.ATUG01000002_gene1690	2.85e-11	62.4	COG1392@1|root,COG1392@2|Bacteria	2|Bacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_1041417_2	391009.Tmel_0789	1.03e-26	108.0	COG0306@1|root,COG0306@2|Bacteria,2GCK4@200918|Thermotogae	200918|Thermotogae	P	PFAM phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_1572502_2	1158292.JPOE01000005_gene1255	0.000192	45.8	2DNW4@1|root,32ZGA@2|Bacteria,1N7ZK@1224|Proteobacteria,2VWJH@28216|Betaproteobacteria,1KM21@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF3306)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3306
k59_1691596_1	1452718.JBOY01000108_gene384	2.68e-63	207.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1S1KY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG2230 Cyclopropane fatty acid synthase and related methyltransferases	cfa2	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_515241_2	765911.Thivi_0903	3.17e-112	335.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria,1WW5Y@135613|Chromatiales	135613|Chromatiales	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1572508_1	1415779.JOMH01000001_gene3177	4.91e-20	82.4	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,1S8U6@1236|Gammaproteobacteria,1X7EJ@135614|Xanthomonadales	135614|Xanthomonadales	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
k59_1572508_2	706191.PANA_0461	8.75e-64	215.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,3VZJ2@53335|Pantoea	1236|Gammaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_801139_2	338966.Ppro_0783	7.45e-39	142.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42N2T@68525|delta/epsilon subdivisions,2WMYV@28221|Deltaproteobacteria,43SP8@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1396332_1	883109.HMPREF0380_01237	5.27e-20	94.7	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,3WCXB@538999|Clostridiales incertae sedis	186801|Clostridia	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.17.1.9,1.3.1.1	ko:K00123,ko:K17722	ko00240,ko00410,ko00630,ko00680,ko00770,ko01100,ko01120,ko01200,map00240,map00410,map00630,map00680,map00770,map01100,map01120,map01200	M00046	R00519,R00977,R01414,R11026	RC00072,RC00123,RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Pyr_redox_2,Pyr_redox_3
k59_869049_1	1249627.D779_2948	9.01e-30	117.0	COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,1RQ6N@1236|Gammaproteobacteria,1WX18@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_869049_2	2340.JV46_14290	3.47e-16	79.3	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_1523827_1	323098.Nwi_0073	5.11e-55	184.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria,3JRJ9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Tetratricopeptide repeat	trxA2	-	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_574042_1	1121035.AUCH01000006_gene746	2.36e-26	112.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,2KUTR@206389|Rhodocyclales	206389|Rhodocyclales	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
k59_633144_1	863239.AFIZ01000040_gene818	9.15e-09	61.6	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,22Q2V@1653|Corynebacteriaceae	201174|Actinobacteria	C	FAD dependent oxidoreductase	lpdA_1	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
k59_1041473_1	1121468.AUBR01000011_gene2473	5.72e-92	279.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,42FEW@68295|Thermoanaerobacterales	186801|Clostridia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_1523833_2	713587.THITH_12735	7.07e-27	103.0	COG0426@1|root,COG0426@2|Bacteria,1PRCG@1224|Proteobacteria,1TKCD@1236|Gammaproteobacteria,1X1UR@135613|Chromatiales	135613|Chromatiales	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1115027_1	880072.Desac_0499	4.54e-169	482.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,42NP0@68525|delta/epsilon subdivisions,2WVG4@28221|Deltaproteobacteria,2MRQ6@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_1221330_1	367299.JOEE01000008_gene409	8.69e-119	345.0	2AVV0@1|root,31MNQ@2|Bacteria,2GJKP@201174|Actinobacteria,4FGM6@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3159
k59_1221330_2	367299.JOEE01000008_gene408	5.76e-16	72.0	COG1200@1|root,COG1200@2|Bacteria,2IHRX@201174|Actinobacteria,4FHW3@85021|Intrasporangiaceae	201174|Actinobacteria	KL	Nucleic acid binding, OB-fold, tRNA	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1691633_1	1173264.KI913949_gene835	1.29e-07	57.8	COG1426@1|root,COG1426@2|Bacteria,1G72S@1117|Cyanobacteria,1HBXP@1150|Oscillatoriales	1117|Cyanobacteria	S	Domain of unknown function (DUF4115)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
k59_1691633_2	1123371.ATXH01000027_gene155	7.66e-06	50.8	COG1381@1|root,COG1381@2|Bacteria,2GHRN@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
k59_1691637_1	1121413.JMKT01000009_gene2010	7.92e-131	388.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2WJXY@28221|Deltaproteobacteria,2M826@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1115048_1	1121405.dsmv_3251	1.61e-93	297.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2MHZG@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
k59_751835_1	497321.C664_06788	5.32e-87	273.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2VIU7@28216|Betaproteobacteria,2KU6N@206389|Rhodocyclales	206389|Rhodocyclales	C	cytochrome	nirN	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_1456728_1	1096930.L284_08615	9.8e-23	104.0	COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2JZUI@204457|Sphingomonadales	28211|Alphaproteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_801167_1	395493.BegalDRAFT_2110	3.75e-23	94.7	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,460KH@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_801167_2	686340.Metal_0770	7.92e-26	98.6	COG2921@1|root,COG2921@2|Bacteria,1PJDX@1224|Proteobacteria,1THTC@1236|Gammaproteobacteria,1XFN8@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0250 family	-	-	-	ko:K09158	-	-	-	-	ko00000	-	-	-	DUF493
k59_1221347_2	936574.HMPREF1508_1646	2.27e-40	149.0	COG3635@1|root,COG3635@2|Bacteria,1TQ5S@1239|Firmicutes,248U6@186801|Clostridia	186801|Clostridia	G	phosphoglycerate mutase	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
k59_1115054_1	1123368.AUIS01000007_gene2704	7.17e-40	139.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1S8WW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_352530_1	177437.HRM2_05410	2.68e-92	281.0	COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,42NSB@68525|delta/epsilon subdivisions,2WIKP@28221|Deltaproteobacteria,2MJ70@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K09970	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
k59_117601_1	479434.Sthe_0958	4.62e-14	75.1	arCOG06048@1|root,31EJQ@2|Bacteria,2G6TM@200795|Chloroflexi,27Z2Z@189775|Thermomicrobia	189775|Thermomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_939602_1	1286106.MPL1_04832	3.68e-21	95.9	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,1RMB0@1236|Gammaproteobacteria,45ZUD@72273|Thiotrichales	72273|Thiotrichales	H	Belongs to the folylpolyglutamate synthase family	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_176312_1	95619.PM1_0226535	5.98e-36	140.0	COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG0643 Chemotaxis protein histidine kinase and related kinases	chpA	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_1291832_1	511062.GU3_05600	1.08e-14	68.6	2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,1SEIJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
k59_1291832_2	768671.ThimaDRAFT_3162	7.12e-16	72.8	COG2261@1|root,COG2261@2|Bacteria,1N72Y@1224|Proteobacteria,1SCD4@1236|Gammaproteobacteria,1X1RW@135613|Chromatiales	135613|Chromatiales	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
k59_1291832_3	768671.ThimaDRAFT_3159	4.29e-154	441.0	COG1376@1|root,COG1376@2|Bacteria,1Q823@1224|Proteobacteria,1S58V@1236|Gammaproteobacteria,1X0Q7@135613|Chromatiales	135613|Chromatiales	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_1350413_1	547045.NEISICOT_00498	1.31e-32	123.0	COG1805@1|root,COG1805@2|Bacteria,1QTUU@1224|Proteobacteria,2VN5U@28216|Betaproteobacteria,2KT8Z@206351|Neisseriales	206351|Neisseriales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrB	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
k59_1350413_2	686578.AFFX01000002_gene945	5.73e-17	81.6	COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,1RR85@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrC	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
k59_1820187_1	710696.Intca_2483	2.78e-83	277.0	COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4FG36@85021|Intrasporangiaceae	201174|Actinobacteria	E	Dehydrogenase	gdh	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
k59_176316_1	159087.Daro_1180	2.49e-09	59.3	COG0745@1|root,COG0745@2|Bacteria,1R8UQ@1224|Proteobacteria,2VQE1@28216|Betaproteobacteria,2KW6W@206389|Rhodocyclales	206389|Rhodocyclales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_176316_2	883126.HMPREF9710_04606	3.74e-71	220.0	COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,2VK6T@28216|Betaproteobacteria,473E7@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
k59_1409108_1	1122228.AQXR01000011_gene584	2.83e-08	55.5	COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria,4CYU0@85004|Bifidobacteriales	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	dppD	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1409108_2	314285.KT71_00425	3.62e-42	155.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,1RMA1@1236|Gammaproteobacteria,1J88U@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
k59_1291841_1	446466.Cfla_1510	1.26e-142	430.0	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4F0Z9@85016|Cellulomonadaceae	201174|Actinobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_352568_1	999141.GME_17993	2.01e-33	125.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,1RQU0@1236|Gammaproteobacteria,1XH71@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_352568_2	498211.CJA_1799	5.89e-19	85.5	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,1RNXE@1236|Gammaproteobacteria,1FGZ6@10|Cellvibrio	1236|Gammaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
k59_1350420_1	639282.DEFDS_0485	2.58e-106	318.0	COG0112@1|root,COG0112@2|Bacteria,2GERI@200930|Deferribacteres	200930|Deferribacteres	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_469822_1	1035308.AQYY01000001_gene2931	5.3e-88	266.0	COG1946@1|root,COG1946@2|Bacteria	2|Bacteria	I	acyl-CoA hydrolase activity	tesB	-	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT_3
k59_1233034_1	472759.Nhal_3420	2.29e-12	66.2	COG1674@1|root,COG3266@1|root,COG1674@2|Bacteria,COG3266@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales	135613|Chromatiales	D	DNA segregation ATPase FtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1233034_2	863365.XHC_2326	6.45e-22	96.3	COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,1S9FW@1236|Gammaproteobacteria,1X5BW@135614|Xanthomonadales	135614|Xanthomonadales	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
k59_1526499_1	1454010.JEOE01000059_gene925	9.21e-52	182.0	COG1165@1|root,COG1165@2|Bacteria,2GMEB@201174|Actinobacteria,4F12X@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
k59_1820208_1	1096756.ATKN01000020_gene1581	3.81e-05	45.4	COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,1W8GG@1268|Micrococcaceae	201174|Actinobacteria	I	Belongs to the 3-hydroxyisobutyrate dehydrogenase family	mmsB	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_1820208_2	243233.MCA0865	1.14e-50	169.0	COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,1RZQU@1236|Gammaproteobacteria,1XEJB@135618|Methylococcales	135618|Methylococcales	S	Belongs to the MtfA family	-	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90
k59_1174309_2	710687.KI912270_gene3271	9.29e-22	93.6	COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria,234SX@1762|Mycobacteriaceae	201174|Actinobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_1585217_2	748658.KB907312_gene1630	1.44e-31	117.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,1WY2P@135613|Chromatiales	135613|Chromatiales	J	catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
k59_1233037_1	525246.HMPREF0058_1442	4.25e-75	231.0	COG0563@1|root,COG0563@2|Bacteria,2GJ7T@201174|Actinobacteria,4D4SK@85005|Actinomycetales	201174|Actinobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
k59_645991_1	391615.ABSJ01000041_gene63	3.15e-108	323.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1J53B@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Aminotransferase	hemL	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iUMNK88_1353.UMNK88_158	Aminotran_3
k59_528535_1	1218084.BBJK01000104_gene6520	3.7e-53	175.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,1K2IP@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
k59_939652_2	1049564.TevJSym_ac00480	2.3e-86	270.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1J4I6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	JKL	DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlE	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_293733_2	590998.Celf_1442	1.59e-79	245.0	COG1478@1|root,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4F123@85016|Cellulomonadaceae	201174|Actinobacteria	C	F420-0:Gamma-glutamyl ligase	fbiB	GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase,Nitroreductase
k59_880973_1	234267.Acid_4215	2.79e-07	55.8	COG1506@1|root,COG1506@2|Bacteria,3Y357@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Tannase and feruloyl esterase	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
k59_1291879_1	1177179.A11A3_09560	7.13e-42	153.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,1QU7C@1224|Proteobacteria,1T1PS@1236|Gammaproteobacteria,1XIBR@135619|Oceanospirillales	135619|Oceanospirillales	T	Histidine kinase	baeS	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_352597_1	1121952.ATXT01000014_gene1376	7.8e-71	239.0	COG2352@1|root,COG2352@2|Bacteria,2GKDB@201174|Actinobacteria,4FMP5@85023|Microbacteriaceae	201174|Actinobacteria	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_1467862_1	1000565.METUNv1_02596	9.99e-44	150.0	COG0723@1|root,COG0723@2|Bacteria,1MZ7A@1224|Proteobacteria,2VVI5@28216|Betaproteobacteria	28216|Betaproteobacteria	C	plastoquinol--plastocyanin reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_822127_1	768671.ThimaDRAFT_0590	4.48e-95	290.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,1RQ3D@1236|Gammaproteobacteria,1WX6U@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
k59_1702670_1	1031711.RSPO_c02362	2.29e-68	216.0	COG3676@1|root,COG3676@2|Bacteria,1QTF7@1224|Proteobacteria,2VQDW@28216|Betaproteobacteria	28216|Betaproteobacteria	L	ISXO2-like transposase domain	-	-	-	ko:K07488	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1595
k59_528994_1	984962.XP_009549895.1	2.55e-12	75.1	KOG0291@1|root,KOG0291@2759|Eukaryota,38DVV@33154|Opisthokonta,3NVZP@4751|Fungi,3UY9M@5204|Basidiomycota,228G7@155619|Agaricomycetes,3H42F@355688|Agaricomycetes incertae sedis	4751|Fungi	A	WD repeat protein	PWP2	GO:0000028,GO:0000447,GO:0000460,GO:0000462,GO:0000466,GO:0000469,GO:0000472,GO:0000478,GO:0000479,GO:0000480,GO:0000920,GO:0000966,GO:0000967,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005732,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0007163,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030010,GO:0030490,GO:0030515,GO:0030684,GO:0030686,GO:0031974,GO:0031981,GO:0032040,GO:0032991,GO:0034388,GO:0034470,GO:0034471,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0051301,GO:0065003,GO:0070013,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:1901360,GO:1901363,GO:1990904	-	ko:K14558	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Utp12,WD40
k59_1057506_1	857087.Metme_2641	1.21e-30	115.0	COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,1RQIE@1236|Gammaproteobacteria,1XF7V@135618|Methylococcales	135618|Methylococcales	M	Belongs to the skp family	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
k59_705202_1	1210045.ALNP01000006_gene5005	1.23e-09	63.2	COG0500@1|root,COG2226@2|Bacteria,2H38T@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_881930_1	883126.HMPREF9710_05157	1.06e-50	177.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria	28216|Betaproteobacteria	I	PFAM Phospholipase D Transphosphatidylase	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_1703145_1	96561.Dole_0851	5.89e-111	353.0	COG0366@1|root,COG3408@1|root,COG0366@2|Bacteria,COG3408@2|Bacteria,1MWBZ@1224|Proteobacteria,43AE9@68525|delta/epsilon subdivisions,2X5U3@28221|Deltaproteobacteria,2MJ5S@213118|Desulfobacterales	28221|Deltaproteobacteria	G	alpha amylase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,GDE_C,GDE_N
k59_1703146_1	469383.Cwoe_2867	2.08e-64	220.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4CP7C@84995|Rubrobacteria	84995|Rubrobacteria	L	DNA polymerase	-	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A
k59_235654_1	1279017.AQYJ01000021_gene2822	4.7e-18	84.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,4641J@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	COG3118 Thioredoxin domain-containing protein	ybbN	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0061077	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_1233564_1	1288826.MSNKSG1_12552	1.62e-18	83.6	COG4176@1|root,COG4176@2|Bacteria,1MUM4@1224|Proteobacteria,1RPQS@1236|Gammaproteobacteria,466J0@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG4176 ABC-type proline glycine betaine transport system, permease component	opuAB	-	-	ko:K02001	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
k59_1233564_2	246200.SPO2443	5.56e-42	148.0	COG4175@1|root,COG4175@2|Bacteria,1MU86@1224|Proteobacteria,2TS8Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG4175 ABC-type proline glycine betaine transport system ATPase component	opuAA	-	3.6.3.32	ko:K02000	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	-	ABC_tran
k59_235657_1	765912.Thimo_2557	5.2e-132	389.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1WVVC@135613|Chromatiales	135613|Chromatiales	F	TIGRFAM dihydroorotase, multifunctional complex type	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_1000_1	479431.Namu_2548	4.59e-18	83.6	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03712	-	-	-	-	ko00000,ko03000	-	-	-	MarR_2
k59_705220_1	1120983.KB894570_gene1957	4.15e-41	147.0	COG3494@1|root,COG3494@2|Bacteria,1MWTH@1224|Proteobacteria,2U4AB@28211|Alphaproteobacteria,1JP1N@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1009)	cdsA2	GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
k59_705220_2	1267005.KB911258_gene97	2.93e-30	114.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2TRK9@28211|Alphaproteobacteria,3N688@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
k59_1409581_1	298386.PBPRB1242	1.88e-101	302.0	COG0786@1|root,COG0786@2|Bacteria,1MVBC@1224|Proteobacteria,1RP0S@1236|Gammaproteobacteria,1XUE5@135623|Vibrionales	135623|Vibrionales	P	Catalyzes the sodium-dependent transport of glutamate	gltS	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
k59_1350949_1	396595.TK90_2032	2.34e-97	307.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales	135613|Chromatiales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_998841_1	648757.Rvan_2342	2.02e-43	157.0	COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,2TS7R@28211|Alphaproteobacteria,3N8AV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Serine carboxypeptidase	MA20_31445	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
k59_1703160_1	1122622.ATWJ01000012_gene1085	9.21e-24	98.2	COG1846@1|root,COG1846@2|Bacteria,2GJ6W@201174|Actinobacteria,4FGMI@85021|Intrasporangiaceae	201174|Actinobacteria	K	MarR family transcriptional regulator	pecS	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
k59_1703160_2	1120972.AUMH01000008_gene2025	8.44e-14	73.2	COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,4ISWU@91061|Bacilli	91061|Bacilli	M	Nad-dependent epimerase dehydratase	yfnG	-	4.2.1.45,4.2.1.46	ko:K01709,ko:K01710	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	M00793	R02426,R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_646533_1	1101195.Meth11DRAFT_1310	1e-06	50.1	COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,2VIZ9@28216|Betaproteobacteria,2KKWX@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Protein of unknown function (DUF1365)	-	-	-	ko:K09701	-	-	-	-	ko00000	-	-	-	DUF1365
k59_646533_2	472759.Nhal_0313	9.31e-171	491.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1WX07@135613|Chromatiales	135613|Chromatiales	M	PFAM Cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_1174852_1	987059.RBXJA2T_00754	9.97e-74	246.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,1KJT4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_176844_1	1123487.KB892834_gene2750	8.04e-18	87.4	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,2VKKI@28216|Betaproteobacteria,2KY4W@206389|Rhodocyclales	206389|Rhodocyclales	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_1409586_1	765910.MARPU_14170	1.86e-48	163.0	COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,1RNPD@1236|Gammaproteobacteria,1WWH6@135613|Chromatiales	135613|Chromatiales	D	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity	zapD	-	-	ko:K18778	-	-	-	-	ko00000,ko03036	-	-	-	ZapD
k59_1526957_1	1049564.TevJSym_bo00190	3.41e-87	283.0	COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,1RQ9A@1236|Gammaproteobacteria,1J616@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	ko:K02569	-	-	-	-	ko00000	-	-	-	Cytochrom_NNT,EB_dh
k59_1468394_1	76636.JOEC01000006_gene47	7.43e-62	204.0	COG1503@1|root,COG1503@2|Bacteria,2HSKA@201174|Actinobacteria,4FP4X@85023|Microbacteriaceae	201174|Actinobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1585691_1	314260.PB2503_11224	1.35e-73	227.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2TSCQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
k59_1644563_1	439235.Dalk_0585	1.12e-66	229.0	COG0577@1|root,COG1340@1|root,COG2234@1|root,COG0577@2|Bacteria,COG1340@2|Bacteria,COG2234@2|Bacteria,1MVYE@1224|Proteobacteria,42PKN@68525|delta/epsilon subdivisions,2WIWP@28221|Deltaproteobacteria,2MIQI@213118|Desulfobacterales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,PA,Peptidase_M28
k59_1017_1	1196095.GAPWK_2170	3.63e-37	139.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	oligopeptidase	prlC	GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006465,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0034645,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051604,GO:0070011,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901576	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_1017_2	1120953.AUBH01000005_gene2198	1.14e-64	204.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria,466EI@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	yrdA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0009987,GO:0016043,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071840	-	-	-	-	-	-	-	-	-	-	Hexapep
k59_1017_3	768671.ThimaDRAFT_4848	1.05e-89	273.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1WW5V@135613|Chromatiales	135613|Chromatiales	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
k59_353598_1	1232437.KL662047_gene5208	1.34e-177	506.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,42P0J@68525|delta/epsilon subdivisions,2WJJQ@28221|Deltaproteobacteria,2MIYI@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Cytochrome bd terminal oxidase subunit I	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_411627_1	639283.Snov_1977	2.88e-08	57.4	COG2863@1|root,COG2863@2|Bacteria,1PFWU@1224|Proteobacteria,2UHIY@28211|Alphaproteobacteria,3F01H@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_411627_2	1123399.AQVE01000005_gene950	5.86e-13	69.3	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria,45ZTP@72273|Thiotrichales	72273|Thiotrichales	S	Flavocytochrome c sulphide dehydrogenase, flavin-binding	-	-	1.8.2.3	ko:K17229	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2
k59_1029_1	335543.Sfum_0313	7.91e-81	248.0	COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,42PN7@68525|delta/epsilon subdivisions,2WIRP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_470343_1	999611.KI421504_gene423	3.19e-24	100.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,2TRRN@28211|Alphaproteobacteria,27ZQ2@191028|Leisingera	28211|Alphaproteobacteria	FL	Metal binding domain of Ada	ada	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
k59_470343_2	710111.FraQA3DRAFT_1755	2.44e-18	83.2	COG0824@1|root,COG0824@2|Bacteria,2IMK1@201174|Actinobacteria	201174|Actinobacteria	S	Thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
k59_998875_1	1123371.ATXH01000021_gene1109	7.65e-26	112.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_118208_1	349521.HCH_00104	3.14e-21	89.4	COG0680@1|root,COG0680@2|Bacteria,1MZE1@1224|Proteobacteria,1SB0K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	hydrogenase maturation protease	hoxW	-	-	-	-	-	-	-	-	-	-	-	-
k59_118208_2	1121935.AQXX01000142_gene2302	5.02e-45	159.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,1T20U@1236|Gammaproteobacteria,1XPVQ@135619|Oceanospirillales	135619|Oceanospirillales	C	Nickel-dependent hydrogenase	-	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
k59_940724_2	160492.XF_2029	2.11e-17	77.0	COG4634@1|root,COG4634@2|Bacteria,1RH7A@1224|Proteobacteria,1SBJT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1821248_1	1030157.AFMP01000026_gene1055	2.15e-46	168.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria,2K2HG@204457|Sphingomonadales	204457|Sphingomonadales	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_1821248_2	472175.EL18_02259	1.64e-25	103.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TS1R@28211|Alphaproteobacteria,43HJ6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Belongs to the thiolase family	fadA	GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006725,GO:0006805,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016020,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019439,GO:0019748,GO:0019752,GO:0030258,GO:0030312,GO:0032787,GO:0033554,GO:0033812,GO:0034440,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0071944,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_940726_1	243233.MCA0769	7.29e-194	575.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1XE3B@135618|Methylococcales	135618|Methylococcales	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1174883_1	1163407.UU7_13033	1.4e-12	67.4	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1X3NP@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1306841_12	390989.JOEG01000004_gene3809	6.6e-07	62.0	COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,4D8N4@85008|Micromonosporales	201174|Actinobacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
k59_538845_1	1242864.D187_002372	4.46e-40	145.0	COG4143@1|root,COG4143@2|Bacteria,1R4IE@1224|Proteobacteria,42QHK@68525|delta/epsilon subdivisions,2WUK2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	(ABC) transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_715260_1	981369.JQMJ01000003_gene7659	4.64e-50	178.0	COG2812@1|root,COG2812@2|Bacteria,2GJKA@201174|Actinobacteria,2NETT@228398|Streptacidiphilus	201174|Actinobacteria	L	DNA polymerase III subunits gamma and tau domain III	dnaX	GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
k59_895731_1	1193181.BN10_160004	3.82e-52	173.0	COG0337@1|root,COG0337@2|Bacteria,2GIUZ@201174|Actinobacteria,4FEDZ@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
k59_17791_1	1121396.KB893066_gene1591	5.78e-10	60.8	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria,2MIJ9@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_9,Sigma54_activat
k59_251437_1	323261.Noc_1362	8.81e-41	145.0	COG0679@1|root,COG0679@2|Bacteria,1RCAI@1224|Proteobacteria,1S2TH@1236|Gammaproteobacteria,1WY0K@135613|Chromatiales	135613|Chromatiales	S	PFAM Auxin Efflux Carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
k59_480041_1	1120950.KB892743_gene3179	1.83e-10	66.6	COG3694@1|root,COG3694@2|Bacteria,2GT76@201174|Actinobacteria,4DUGA@85009|Propionibacteriales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_6
k59_771973_1	756272.Plabr_0707	9.36e-86	274.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_11,TPR_12,TPR_8
k59_1306850_1	933262.AXAM01000029_gene2742	2.07e-79	242.0	COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,42MCM@68525|delta/epsilon subdivisions,2WKRE@28221|Deltaproteobacteria,2MJ7J@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
k59_1594743_1	1283300.ATXB01000001_gene2403	1.66e-104	317.0	COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,1RXZ7@1236|Gammaproteobacteria,1XE3M@135618|Methylococcales	135618|Methylococcales	S	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
k59_251448_1	1123073.KB899242_gene1028	6.34e-93	281.0	COG1028@1|root,COG1028@2|Bacteria,1MWJI@1224|Proteobacteria,1S2WT@1236|Gammaproteobacteria,1X562@135614|Xanthomonadales	135614|Xanthomonadales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
k59_1654828_1	861299.J421_4099	4.75e-17	86.7	COG0577@1|root,COG0577@2|Bacteria	861299.J421_4099|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_480047_1	909663.KI867150_gene248	7e-76	242.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2WJQQ@28221|Deltaproteobacteria,2MQT7@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.16,1.2.1.18,1.2.1.20,1.2.1.27,1.2.1.3,1.2.1.79,1.2.1.9	ko:K00128,ko:K00131,ko:K00135,ko:K00140	ko00010,ko00030,ko00053,ko00071,ko00250,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00562,ko00620,ko00625,ko00640,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00562,map00620,map00625,map00640,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130,map01200	M00013,M00027,M00135,M00308,M00633	R00264,R00631,R00705,R00706,R00710,R00713,R00714,R00904,R00922,R00935,R01058,R01752,R01986,R02401,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00004,RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_954718_1	1095767.CAHD01000058_gene337	9.06e-43	151.0	COG0477@1|root,COG0477@2|Bacteria,2I2KV@201174|Actinobacteria,4F0MW@85016|Cellulomonadaceae	201174|Actinobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_17818_1	449447.MAE_58430	3.82e-49	168.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1G3YK@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23
k59_1480884_1	1121937.AUHJ01000001_gene613	7.53e-30	114.0	COG0391@1|root,COG0391@2|Bacteria,1NK78@1224|Proteobacteria,1RZ77@1236|Gammaproteobacteria,467KY@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Uncharacterised protein family UPF0052	-	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
k59_1480884_2	1168065.DOK_07739	1.98e-11	63.5	COG1478@1|root,COG1478@2|Bacteria,1PQHN@1224|Proteobacteria,1S12T@1236|Gammaproteobacteria,1J5KY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	F420-0:Gamma-glutamyl ligase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
k59_954731_1	644282.Deba_0507	2.32e-28	120.0	COG0457@1|root,COG2199@1|root,COG0457@2|Bacteria,COG2199@2|Bacteria,1RDNA@1224|Proteobacteria,42Q5I@68525|delta/epsilon subdivisions,2WIX0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_7,TPR_8
k59_1770926_1	879212.DespoDRAFT_02655	2.27e-34	134.0	COG1085@1|root,COG1085@2|Bacteria,1R6SM@1224|Proteobacteria,42QFF@68525|delta/epsilon subdivisions,2WKFN@28221|Deltaproteobacteria,2MIE7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	galactose-1-phosphate uridylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_480055_1	765910.MARPU_00500	3.52e-76	242.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1WXUS@135613|Chromatiales	135613|Chromatiales	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_480055_2	1163617.SCD_n02326	1.43e-121	358.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2VH2S@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Nadh flavin oxidoreductase nadh oxidase	nemA	GO:0000003,GO:0000302,GO:0001101,GO:0003006,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006950,GO:0006979,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009605,GO:0009607,GO:0009620,GO:0009694,GO:0009695,GO:0009791,GO:0009908,GO:0009987,GO:0010035,GO:0010193,GO:0010817,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016629,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0042221,GO:0042445,GO:0042446,GO:0042493,GO:0042579,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046677,GO:0048367,GO:0048437,GO:0048438,GO:0048443,GO:0048466,GO:0048608,GO:0048731,GO:0048827,GO:0048856,GO:0050896,GO:0051704,GO:0051707,GO:0055114,GO:0061458,GO:0065007,GO:0065008,GO:0071704,GO:0072330,GO:0090567,GO:0099402,GO:1901576,GO:1901700	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
k59_367497_1	1122933.JNIY01000004_gene2140	9.96e-80	245.0	2CAAY@1|root,32RR1@2|Bacteria,2IJQS@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_367497_2	66874.JOFS01000002_gene7318	4.54e-27	103.0	COG3654@1|root,COG3654@2|Bacteria,2IR34@201174|Actinobacteria	201174|Actinobacteria	S	TIGRFAM death-on-curing family protein	doc	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
k59_367497_3	1151122.AQYD01000006_gene1983	1.71e-28	111.0	29YYI@1|root,30KVC@2|Bacteria,2IGN9@201174|Actinobacteria	201174|Actinobacteria	S	Nuclease-related domain	-	-	-	-	-	-	-	-	-	-	-	-	NERD
k59_367497_4	1211815.CBYP010000015_gene2754	1.73e-12	68.9	COG0582@1|root,COG0582@2|Bacteria,2GTYQ@201174|Actinobacteria,4EW1T@85013|Frankiales	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
k59_1124381_1	717785.HYPMC_4428	3.78e-72	229.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2TS98@28211|Alphaproteobacteria,3N66D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
k59_656626_2	251221.35212927	7.97e-100	312.0	COG0405@1|root,COG0405@2|Bacteria,1G20A@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM Gamma-glutamyltranspeptidase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1480899_1	1156919.QWC_06749	3.4e-38	143.0	COG0436@1|root,COG0436@2|Bacteria,1QE0D@1224|Proteobacteria,2VIUB@28216|Betaproteobacteria,3T5J5@506|Alcaligenaceae	28216|Betaproteobacteria	E	Aminotransferase class I and II	asdA	-	4.1.1.12	ko:K09758	ko00250,ko00270,ko01100,ko01230,map00250,map00270,map01100,map01230	-	R00397,R00863	RC00282,RC00399,RC00400	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
k59_17854_1	278957.ABEA03000201_gene4325	1.17e-108	337.0	COG0444@1|root,COG4608@1|root,COG0444@2|Bacteria,COG4608@2|Bacteria,46U8E@74201|Verrucomicrobia,3KA26@414999|Opitutae	414999|Opitutae	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_715290_1	547163.BN979_06261	1.7e-79	255.0	COG2373@1|root,COG2373@2|Bacteria,2H4M3@201174|Actinobacteria,236MB@1762|Mycobacteriaceae	201174|Actinobacteria	S	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,Catalase
k59_1835123_1	261292.Nit79A3_2959	1.06e-100	312.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,372QB@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_954742_1	590998.Celf_0185	7.06e-47	155.0	COG2197@1|root,COG2197@2|Bacteria,2GNUE@201174|Actinobacteria	201174|Actinobacteria	K	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE
k59_251491_1	765913.ThidrDRAFT_2111	1.02e-79	242.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,1WWJX@135613|Chromatiales	135613|Chromatiales	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
k59_251491_2	105559.Nwat_0689	3.62e-142	414.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,1WW8U@135613|Chromatiales	135613|Chromatiales	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_538879_1	309801.trd_1309	5.83e-35	130.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2G5TN@200795|Chloroflexi,27YS0@189775|Thermomicrobia	189775|Thermomicrobia	HP	ThiF family	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,ThiF
k59_538879_2	1229780.BN381_150094	8.37e-23	90.9	COG1977@1|root,COG1977@2|Bacteria,2IQBT@201174|Actinobacteria,3UXHU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
k59_367511_1	1096546.WYO_1390	8.99e-68	224.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,1JRTC@119045|Methylobacteriaceae	28211|Alphaproteobacteria	V	ABC transporter	exsA	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_895775_1	926550.CLDAP_08990	1.14e-47	166.0	COG0530@1|root,COG0530@2|Bacteria,2G6GV@200795|Chloroflexi	200795|Chloroflexi	P	PFAM sodium calcium exchanger membrane region	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_895775_2	631362.Thi970DRAFT_02355	1.48e-13	70.9	COG2802@1|root,COG2802@2|Bacteria,1NV9N@1224|Proteobacteria,1SAAZ@1236|Gammaproteobacteria,1WXGU@135613|Chromatiales	135613|Chromatiales	S	peptidase S16, lon	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
k59_1770939_1	367299.JOEE01000002_gene2353	1.82e-90	269.0	COG1595@1|root,COG1595@2|Bacteria,2GJUI@201174|Actinobacteria,4FGYD@85021|Intrasporangiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
k59_1185106_1	999141.GME_12469	4.51e-20	82.4	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,1S8U6@1236|Gammaproteobacteria,1XKH9@135619|Oceanospirillales	135619|Oceanospirillales	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
k59_1185106_2	187272.Mlg_1944	1.01e-107	331.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1WW27@135613|Chromatiales	135613|Chromatiales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_1770940_1	1217656.F964_01220	1.77e-17	85.1	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,3NIQA@468|Moraxellaceae	1236|Gammaproteobacteria	D	recombinase XerD	xerD	GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_772002_1	419610.Mext_1335	2.1e-22	99.0	COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2TR6Z@28211|Alphaproteobacteria,1JU0D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	TIGRFAM 40-residue YVTN family beta-propeller repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
k59_367522_1	1122917.KB899660_gene1806	9.34e-10	62.4	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,4HABP@91061|Bacilli,26TPG@186822|Paenibacillaceae	91061|Bacilli	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	-	2.4.2.1,2.4.2.28	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
k59_303944_2	717785.HYPMC_4072	4.55e-37	134.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2TQPN@28211|Alphaproteobacteria,3N6BE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_17888_1	880072.Desac_0173	6.72e-77	253.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2WJ3W@28221|Deltaproteobacteria,2MR18@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_480080_1	768671.ThimaDRAFT_2813	5.34e-127	371.0	COG2235@1|root,COG2235@2|Bacteria,1NCGV@1224|Proteobacteria,1RM99@1236|Gammaproteobacteria,1WZMQ@135613|Chromatiales	135613|Chromatiales	E	Arginine deiminase	arcA	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
k59_17895_1	521719.ATXQ01000001_gene440	3.18e-59	194.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1YCYT@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006464,GO:0006479,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0010468,GO:0016043,GO:0016740,GO:0016741,GO:0018364,GO:0019222,GO:0019538,GO:0022411,GO:0032259,GO:0032984,GO:0034641,GO:0034645,GO:0036009,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043414,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
k59_17895_2	1122134.KB893651_gene1961	2.62e-184	521.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1XHU3@135619|Oceanospirillales	135619|Oceanospirillales	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_17895_3	207954.MED92_17237	5.83e-67	219.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1XHBS@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_715323_1	880072.Desac_0822	1e-82	274.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_187043_1	335543.Sfum_2390	1.14e-68	219.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,42R8A@68525|delta/epsilon subdivisions,2WM6Z@28221|Deltaproteobacteria,2MQHG@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
k59_17907_1	1479238.JQMZ01000001_gene1960	4.13e-57	196.0	COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2U44P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1360412_1	13349.G1XGX0	4.46e-28	124.0	COG0654@1|root,KOG3855@2759|Eukaryota,39XHI@33154|Opisthokonta,3P16X@4751|Fungi,3QKY1@4890|Ascomycota	4751|Fungi	CH	monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_1360412_2	13684.SNOT_09121	1.75e-05	50.4	2E12I@1|root,2S8F2@2759|Eukaryota,39JPG@33154|Opisthokonta,3Q41C@4751|Fungi,3RM5R@4890|Ascomycota,202HM@147541|Dothideomycetes,4KD3P@92860|Pleosporales	4751|Fungi	S	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	GFA,Methyltransf_31
k59_715326_1	1349820.M707_09145	1.65e-10	62.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria	201174|Actinobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_715326_2	1151119.KB895489_gene650	3.32e-112	342.0	COG0365@1|root,COG0365@2|Bacteria,2GNE8@201174|Actinobacteria	201174|Actinobacteria	I	synthetase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_1835177_1	1234364.AMSF01000075_gene1949	4.35e-70	219.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1X4E7@135614|Xanthomonadales	135614|Xanthomonadales	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
k59_1835177_2	187272.Mlg_2443	6.3e-19	79.7	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,1WYPW@135613|Chromatiales	135613|Chromatiales	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
k59_17916_1	1485544.JQKP01000002_gene1430	2.82e-115	361.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,44WE3@713636|Nitrosomonadales	28216|Betaproteobacteria	P	MMPL family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
k59_538914_1	575540.Isop_1760	5.56e-53	192.0	COG0526@1|root,COG3391@1|root,COG0526@2|Bacteria,COG3391@2|Bacteria,2IXWV@203682|Planctomycetes	203682|Planctomycetes	CO	PFAM NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL,Thioredoxin_8
k59_1071499_1	1385521.N803_02770	6.64e-76	233.0	COG1948@1|root,COG1948@2|Bacteria,2HAMQ@201174|Actinobacteria,4FF1Z@85021|Intrasporangiaceae	201174|Actinobacteria	L	ERCC4 domain	-	-	-	-	-	-	-	-	-	-	-	-	ERCC4,Lsr2
k59_598017_1	314278.NB231_09978	1.54e-76	244.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WVVT@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_304679_1	1049564.TevJSym_ao00750	2.16e-80	247.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,1J52U@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	COG1077 Actin-like ATPase involved in cell morphogenesis	mreB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_1361207_1	570952.ATVH01000018_gene3329	2.88e-66	213.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,2JPE7@204441|Rhodospirillales	204441|Rhodospirillales	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1247013_1	991905.SL003B_0986	1.45e-130	376.0	COG0464@1|root,COG0464@2|Bacteria,1MUCN@1224|Proteobacteria,2TVFY@28211|Alphaproteobacteria,4BSCW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	PFAM ATPase family associated with various cellular activities (AAA)	cbbX	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_304680_1	765914.ThisiDRAFT_1110	9.7e-98	302.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1WWJ8@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_598018_1	1415779.JOMH01000001_gene3135	2.3e-104	311.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1S4HN@1236|Gammaproteobacteria,1X9SZ@135614|Xanthomonadales	135614|Xanthomonadales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_598018_2	1415779.JOMH01000001_gene3134	2.02e-41	146.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1S670@1236|Gammaproteobacteria,1X9PH@135614|Xanthomonadales	135614|Xanthomonadales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_1771699_1	1461693.ATO10_13079	7.75e-87	270.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1420900_1	1095767.CAHD01000065_gene3072	1.42e-77	243.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4F0IR@85016|Cellulomonadaceae	201174|Actinobacteria	E	PFAM aminotransferase class I and II	aspB	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1307998_1	653386.HMPREF0975_00226	6.42e-79	245.0	COG0730@1|root,COG0730@2|Bacteria,2GNPE@201174|Actinobacteria,4D55H@85005|Actinomycetales	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	cysZ	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_75111_1	1214242.B446_34960	1.05e-33	134.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE,TPR_12
k59_488045_2	1429851.X548_05535	4.32e-84	260.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1X3TB@135614|Xanthomonadales	135614|Xanthomonadales	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_1082413_1	379731.PST_0412	5.38e-29	114.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,1RVNC@1236|Gammaproteobacteria,1Z135@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_1082413_2	301.JNHE01000003_gene1898	1.45e-54	198.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	slt	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009274,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	iETEC_1333.ETEC_4747,iPC815.YPO0452	SLT,SLT_L
k59_1013633_1	446466.Cfla_1925	1.04e-06	51.6	COG0204@1|root,COG0204@2|Bacteria,2GP8A@201174|Actinobacteria,4F16T@85016|Cellulomonadaceae	201174|Actinobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_1013633_2	1713.JOFV01000015_gene1788	4.86e-82	252.0	COG0283@1|root,COG0283@2|Bacteria,2H3SI@201174|Actinobacteria,4F0T2@85016|Cellulomonadaceae	201174|Actinobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyltransferase,Cytidylate_kin
k59_1491182_1	1122139.KB907870_gene968	4.71e-13	73.6	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,1XJCT@135619|Oceanospirillales	135619|Oceanospirillales	O	Thioredoxin domain-containing protein	trx-1	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_136433_1	1410632.JHWW01000011_gene2436	6.01e-33	121.0	COG0742@1|root,COG0742@2|Bacteria,1V3JF@1239|Firmicutes,24JHR@186801|Clostridia,27MPE@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Conserved hypothetical protein 95	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
k59_136433_2	586416.GZ22_17950	7.41e-13	69.7	COG0619@1|root,COG0619@2|Bacteria,1TQ0E@1239|Firmicutes,4H9VT@91061|Bacilli	91061|Bacilli	P	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfT	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
k59_1779084_1	1121405.dsmv_3476	1.38e-142	428.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2WJ3E@28221|Deltaproteobacteria,2MJ6A@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_2300	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_488049_1	667015.Bacsa_1610	2.67e-20	95.1	COG3533@1|root,COG3533@2|Bacteria,4NFW3@976|Bacteroidetes,2FM1I@200643|Bacteroidia,4AKRG@815|Bacteroidaceae	976|Bacteroidetes	S	protein conserved in bacteria	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	F5_F8_type_C,Glyco_hydro_127
k59_263429_1	933262.AXAM01000019_gene1086	6.09e-59	191.0	COG2221@1|root,COG2221@2|Bacteria,1R5F8@1224|Proteobacteria,42PB3@68525|delta/epsilon subdivisions,2WKJR@28221|Deltaproteobacteria,2MHQY@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Proto-chlorophyllide reductase 57 kD subunit	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6,Fer4_7,NIR_SIR,PCP_red
k59_85145_1	357808.RoseRS_3786	5.63e-29	118.0	COG0707@1|root,COG0707@2|Bacteria,2G6EH@200795|Chloroflexi,374ZS@32061|Chloroflexia	32061|Chloroflexia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_1779087_1	582744.Msip34_2443	1.29e-50	182.0	COG4206@1|root,COG4206@2|Bacteria,1N71E@1224|Proteobacteria,2VJZ9@28216|Betaproteobacteria,2KKW2@206350|Nitrosomonadales	206350|Nitrosomonadales	H	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_378730_1	1120963.KB894500_gene100	4.58e-85	268.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	oligopeptide transporter	-	-	-	-	-	-	-	-	-	-	-	-	OPT
k59_195783_1	1284679.HMPREF1626_04995	2.06e-168	490.0	COG0296@1|root,COG0296@2|Bacteria,2GJ5C@201174|Actinobacteria,4D3EP@85005|Actinomycetales	201174|Actinobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0055114,GO:0071704,GO:0071944,GO:1901576	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_264640_1	863365.XHC_2621	1.9e-20	92.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1X3CI@135614|Xanthomonadales	135614|Xanthomonadales	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
k59_264640_2	767434.Fraau_0876	8.01e-98	297.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,1RMD9@1236|Gammaproteobacteria,1X3CD@135614|Xanthomonadales	135614|Xanthomonadales	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
k59_1429005_1	2340.JV46_15450	4e-35	132.0	COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S dicluster domain	dsrK	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8
k59_1847435_2	472759.Nhal_2872	7.45e-109	350.0	COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1SYTD@1236|Gammaproteobacteria,1X2IM@135613|Chromatiales	135613|Chromatiales	EO	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M1,Peptidase_M28
k59_1847437_1	313595.P700755_002781	3.29e-40	149.0	COG3385@1|root,COG3385@2|Bacteria,4NKTU@976|Bacteroidetes,1I7NH@117743|Flavobacteriia	976|Bacteroidetes	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k59_30775_1	246196.MSMEI_1969	3.9e-09	57.4	COG1118@1|root,COG1118@2|Bacteria,2I2RQ@201174|Actinobacteria,2342T@1762|Mycobacteriaceae	201174|Actinobacteria	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system	modC	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
k59_30775_2	446466.Cfla_2023	1.53e-82	259.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinP	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k59_1369396_1	1121405.dsmv_3295	5.92e-92	280.0	COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,42MH1@68525|delta/epsilon subdivisions,2WJD7@28221|Deltaproteobacteria,2MI33@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Na transporting methylmalonyl-CoA oxaloacetate decarboxylase beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
k59_1492092_1	926549.KI421517_gene1977	4.01e-100	319.0	COG1251@1|root,COG1251@2|Bacteria,4NE44@976|Bacteroidetes,47M7X@768503|Cytophagia	976|Bacteroidetes	C	Nitrite and sulphite reductase 4Fe-4S	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
k59_1257484_1	880072.Desac_0380	7.99e-40	143.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MXG@68525|delta/epsilon subdivisions,2WJ6G@28221|Deltaproteobacteria,2MQ3U@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	aminotransferase, class I and II	-	-	2.6.1.1	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_547374_1	396588.Tgr7_0270	1.03e-93	286.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_379820_1	765910.MARPU_14310	2.4e-40	143.0	COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,1RY2B@1236|Gammaproteobacteria,1WY1Q@135613|Chromatiales	135613|Chromatiales	S	PFAM transport-associated	-	-	-	-	-	-	-	-	-	-	-	-	BON
k59_379820_2	999141.GME_03677	2.07e-36	129.0	COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,1RS1Y@1236|Gammaproteobacteria,1XI6S@135619|Oceanospirillales	135619|Oceanospirillales	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271,ko:K12961	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005,ko03036	-	-	-	SIS_2
k59_967078_1	335543.Sfum_0688	3.38e-62	209.0	COG2206@1|root,COG2206@2|Bacteria,1N5T4@1224|Proteobacteria,43AMJ@68525|delta/epsilon subdivisions,2X61J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
k59_1193985_1	632292.Calhy_1765	3.17e-38	142.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,42ETH@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_1193985_2	1437882.AZRU01000045_gene4801	7.27e-79	239.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,1YD98@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	G	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
k59_1847467_1	446466.Cfla_1359	7.17e-73	220.0	COG2346@1|root,COG2346@2|Bacteria,2IKPF@201174|Actinobacteria,4F1D1@85016|Cellulomonadaceae	201174|Actinobacteria	S	Bacterial-like globin	glbO	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
k59_86295_1	472759.Nhal_0903	3.72e-105	331.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1WXI8@135613|Chromatiales	135613|Chromatiales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_137224_1	1304275.C41B8_16084	8.36e-29	116.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RY47@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	UvrD-like helicase C-terminal domain	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_137224_2	396014.BF93_06420	1.58e-29	113.0	COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,4FBMD@85020|Dermabacteraceae	201174|Actinobacteria	GK	ROK family	ppgK	-	2.7.1.2,2.7.1.63	ko:K00845,ko:K00886	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786,R02187,R02189	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_967080_1	472759.Nhal_0031	4.52e-12	62.0	COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,1S9B2@1236|Gammaproteobacteria,1WYI8@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
k59_967080_2	765912.Thimo_0558	1.59e-76	236.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,1RN1J@1236|Gammaproteobacteria,1WWMS@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
k59_1429039_1	1713.JOFV01000001_gene1978	1.39e-77	241.0	COG0566@1|root,COG0566@2|Bacteria,2GJMR@201174|Actinobacteria,4F0TU@85016|Cellulomonadaceae	201174|Actinobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	rlmB	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
k59_1257497_1	1046724.KB889876_gene340	1.32e-32	126.0	COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,1MW8M@1224|Proteobacteria,1RQPH@1236|Gammaproteobacteria,467PM@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_1257497_2	596151.DesfrDRAFT_2327	1.96e-104	308.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,42N90@68525|delta/epsilon subdivisions,2WJUU@28221|Deltaproteobacteria,2M9HT@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	response regulator, receiver	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_312920_1	889378.Spiaf_1186	1.63e-77	244.0	COG1816@1|root,COG1816@2|Bacteria	2|Bacteria	F	deaminase activity	add	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
k59_908153_1	429009.Adeg_1312	1.15e-27	109.0	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,42EM8@68295|Thermoanaerobacterales	186801|Clostridia	T	protein phosphatase 2C domain protein	prpC	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2,SpoIIE
k59_1319341_1	1385519.N801_14490	7.85e-43	153.0	COG1012@1|root,COG1012@2|Bacteria,2GJZE@201174|Actinobacteria,4FFQI@85021|Intrasporangiaceae	201174|Actinobacteria	C	Dehydrogenase	rocA	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_841263_1	1267005.KB911257_gene986	5.75e-62	214.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria,3N6KE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_137234_1	1121405.dsmv_1035	5.78e-36	125.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,42TN3@68525|delta/epsilon subdivisions,2WQ23@28221|Deltaproteobacteria,2MKNN@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
k59_264703_1	765913.ThidrDRAFT_1677	1.35e-59	194.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,1RSHS@1236|Gammaproteobacteria,1WXWI@135613|Chromatiales	135613|Chromatiales	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	-	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
k59_1492126_1	316056.RPC_4834	2.61e-104	320.0	COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,2TRTR@28211|Alphaproteobacteria,3JS29@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Saccharopine dehydrogenase C-terminal domain	hss	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_379858_1	1121405.dsmv_3773	1.85e-77	255.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,42NY6@68525|delta/epsilon subdivisions,2WJSE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_137239_2	472759.Nhal_2510	5.89e-71	224.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1WX3U@135613|Chromatiales	135613|Chromatiales	C	PFAM Alcohol dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_30841_1	1318628.MARLIPOL_13534	1.47e-74	244.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,46499@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG0608 Single-stranded DNA-specific exonuclease	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_430090_1	1396141.BATP01000003_gene5199	1.72e-99	300.0	COG1509@1|root,COG1509@2|Bacteria,46SVQ@74201|Verrucomicrobia,2ITNU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Lysine-2,3-aminomutase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,LAM_C,Radical_SAM
k59_908180_1	1454010.JEOE01000038_gene1302	4.94e-48	166.0	COG1028@1|root,COG1028@2|Bacteria,2GJCZ@201174|Actinobacteria,4F13K@85016|Cellulomonadaceae	201174|Actinobacteria	IQ	PFAM short-chain dehydrogenase reductase SDR	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1194013_1	445970.ALIPUT_01265	1.21e-73	235.0	COG0010@1|root,COG0010@2|Bacteria,4NE01@976|Bacteroidetes,2FSS3@200643|Bacteroidia	976|Bacteroidetes	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
k59_1429065_1	187944.H8YJB1_9CAUD	3.25e-15	82.0	4QGMJ@10239|Viruses,4QX02@35237|dsDNA viruses  no RNA stage,4QSYG@28883|Caudovirales,4QM5B@10699|Siphoviridae	10699|Siphoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_665501_1	765910.MARPU_03440	1.45e-61	208.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,1WWAN@135613|Chromatiales	135613|Chromatiales	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1132495_1	1366050.N234_13155	3.45e-34	122.0	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,2VRMG@28216|Betaproteobacteria,1K74K@119060|Burkholderiaceae	28216|Betaproteobacteria	H	PFAM molybdopterin biosynthesis MoaE	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
k59_1132495_2	292.DM42_3249	7.37e-23	90.5	COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,2VVSP@28216|Betaproteobacteria,1K984@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
k59_1132495_3	414684.RC1_0102	9.76e-63	197.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria,2JS81@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
k59_1132495_4	2340.JV46_21730	5.96e-98	301.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1J4IQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	COG0303 Molybdopterin biosynthesis enzyme	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_264731_1	754476.Q7A_2839	5.95e-162	468.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,4601B@72273|Thiotrichales	72273|Thiotrichales	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_665502_1	349966.DJ58_2926	2.95e-07	57.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,41EBB@629|Yersinia	1236|Gammaproteobacteria	O	cysteine desulfurase activator complex subunit SufD	sufD	GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840	-	ko:K09015	-	-	-	-	ko00000	-	-	iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144	UPF0051
k59_86349_1	555779.Dthio_PD2973	9.34e-40	150.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,42MVQ@68525|delta/epsilon subdivisions,2WKBG@28221|Deltaproteobacteria,2M7VH@213115|Desulfovibrionales	28221|Deltaproteobacteria	CO	PFAM cytochrome c biogenesis protein transmembrane region	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin,Thioredoxin_7
k59_1779931_1	1051985.l11_01640	9.68e-41	150.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,2KQD0@206351|Neisseriales	206351|Neisseriales	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_1083471_1	472759.Nhal_2460	1.1e-22	98.2	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1WXD9@135613|Chromatiales	135613|Chromatiales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_1083471_2	765914.ThisiDRAFT_1087	2.54e-60	202.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1WW2V@135613|Chromatiales	135613|Chromatiales	M	zinc metalloprotease	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_86356_1	279714.FuraDRAFT_3733	2.33e-25	102.0	COG3103@1|root,COG3103@2|Bacteria,1QVCP@1224|Proteobacteria	1224|Proteobacteria	T	Sh3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_137257_1	1452718.JBOY01000004_gene3127	4.99e-58	194.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3329,HATPase_c,HisKA,PAS,PAS_8
k59_86358_1	439235.Dalk_1777	2.79e-57	185.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,42MES@68525|delta/epsilon subdivisions,2WIQK@28221|Deltaproteobacteria,2MIUS@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_30873_1	861299.J421_3848	4.69e-92	289.0	COG0443@1|root,COG0443@2|Bacteria,1ZT75@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_1319394_1	2340.JV46_05690	7.27e-186	524.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1JBRQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	L COG2826 Transposase and inactivated derivatives, IS30 family	insI	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
k59_908207_1	1121459.AQXE01000008_gene807	1.42e-64	203.0	COG0247@1|root,COG0247@2|Bacteria,1N5Q2@1224|Proteobacteria,42P5D@68525|delta/epsilon subdivisions,2WJ9I@28221|Deltaproteobacteria,2M7XG@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8,Fer4_9
k59_967151_1	582899.Hden_2000	1.34e-35	131.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2TS7C@28211|Alphaproteobacteria,3N6IM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
k59_1779941_1	591159.ACEZ01000167_gene3503	1.28e-55	184.0	COG3547@1|root,COG3547@2|Bacteria,2GNQB@201174|Actinobacteria	201174|Actinobacteria	L	transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_30878_1	983545.Glaag_0444	3.52e-92	295.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,46544@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_908208_1	1306174.JODP01000001_gene5102	3.08e-124	392.0	COG1330@1|root,COG1330@2|Bacteria,2GNVB@201174|Actinobacteria	201174|Actinobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity	recC	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
k59_967153_1	269799.Gmet_2767	7.31e-88	285.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42Y60@68525|delta/epsilon subdivisions,2WUR1@28221|Deltaproteobacteria,43T95@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_379908_1	765913.ThidrDRAFT_0406	8.33e-52	183.0	COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1WWHI@135613|Chromatiales	135613|Chromatiales	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	TPR_1,TPR_16,VWA_2
k59_967157_1	367299.JOEE01000001_gene1656	1.67e-22	93.6	COG0637@1|root,COG0637@2|Bacteria,2GNX0@201174|Actinobacteria,4FH4Q@85021|Intrasporangiaceae	201174|Actinobacteria	S	Haloacid dehalogenase-like hydrolase	yfbT	-	3.1.3.23	ko:K19270	-	-	-	-	ko00000,ko01000	-	-	-	HAD_2
k59_967157_2	367299.JOEE01000001_gene1657	5.41e-57	191.0	COG3573@1|root,COG3573@2|Bacteria,2GIYM@201174|Actinobacteria,4FFER@85021|Intrasporangiaceae	201174|Actinobacteria	S	Proposed role in polysaccahride synthesis	-	-	-	ko:K07077	-	-	-	-	ko00000	-	-	-	FAD_binding_2
k59_547438_1	2340.JV46_25240	2.19e-67	211.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RXB4@1236|Gammaproteobacteria,1JAMN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	-	-	-	-	-	-	-	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_195857_1	710696.Intca_3562	2.09e-43	157.0	COG0477@1|root,COG0477@2|Bacteria,2GK8M@201174|Actinobacteria,4FG58@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_723942_1	367299.JOEE01000001_gene1501	1.25e-106	316.0	COG3718@1|root,COG3718@2|Bacteria,2GM8S@201174|Actinobacteria,4FFG9@85021|Intrasporangiaceae	201174|Actinobacteria	G	5-deoxyglucuronate isomerase	iolB	-	5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08503	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
k59_908245_2	384765.SIAM614_29596	1.47e-84	259.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2TSVK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	small subunit	hupS	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
k59_1664020_1	909613.UO65_0252	4.51e-60	209.0	COG0272@1|root,COG0272@2|Bacteria,2GJUY@201174|Actinobacteria,4E0P6@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
k59_1257592_1	1166018.FAES_2843	0.000839	47.8	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	infB	-	-	ko:K02519,ko:K03112,ko:K21470	-	-	-	-	ko00000,ko01002,ko01011,ko03012,ko03029	-	-	-	AAA_22,GTP_EFTU,IF-2,IF2_N,PG_binding_1,SPOR,YkuD
k59_1611085_1	471853.Bcav_3246	9.87e-120	356.0	COG1470@1|root,COG1470@2|Bacteria,2GP8D@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
k59_1021001_1	1454010.JEOE01000008_gene1870	1.22e-51	187.0	COG0515@1|root,COG0515@2|Bacteria,2GMY7@201174|Actinobacteria	201174|Actinobacteria	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	NERD,Pkinase
k59_1266947_1	1123401.JHYQ01000018_gene2336	1.18e-16	75.5	COG2166@1|root,COG2166@2|Bacteria,1RI8F@1224|Proteobacteria,1S65C@1236|Gammaproteobacteria,460WR@72273|Thiotrichales	72273|Thiotrichales	S	Fe-S metabolism associated domain	-	-	-	ko:K02426	-	-	-	-	ko00000	-	-	-	SufE
k59_1266947_2	381666.H16_B1517	4.7e-41	139.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2VPN0@28216|Betaproteobacteria,1K9RA@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Iron-sulfur cluster assembly protein	sufT	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
k59_1092714_1	1122929.KB908216_gene2135	5.21e-41	155.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	double-strand break repair protein AddB	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
k59_849217_1	1492922.GY26_07490	7.92e-83	258.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1J4PI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the GARS family	purD	GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01945,ko:K13713	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729	GARS_A,GARS_C,GARS_N
k59_438093_2	497321.C664_15103	9.4e-84	262.0	COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,2VQCX@28216|Betaproteobacteria	28216|Betaproteobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_100068_1	587753.EY04_03170	5.74e-14	78.6	COG2207@1|root,COG2207@2|Bacteria,1R53W@1224|Proteobacteria,1RZCR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding_2,HTH_18
k59_1333268_1	1288494.EBAPG3_28540	7.85e-70	226.0	COG0438@1|root,COG0438@2|Bacteria,1RBQV@1224|Proteobacteria,2W3QE@28216|Betaproteobacteria,371TA@32003|Nitrosomonadales	28216|Betaproteobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_43068_2	713587.THITH_09425	1.53e-15	72.8	COG2938@1|root,COG2938@2|Bacteria,1N7P4@1224|Proteobacteria,1SCKB@1236|Gammaproteobacteria,1WZ6Q@135613|Chromatiales	135613|Chromatiales	S	Flavinator of succinate dehydrogenase	-	-	-	ko:K09159	-	-	-	-	ko00000,ko02048	-	-	-	Sdh5
k59_1672029_2	1049564.TevJSym_bh00140	1.62e-64	205.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1J4N9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0714 MoxR-like ATPases	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_673398_1	765912.Thimo_1840	2.67e-35	126.0	COG3945@1|root,COG3945@2|Bacteria,1RM01@1224|Proteobacteria,1S7CW@1236|Gammaproteobacteria,1WY0X@135613|Chromatiales	135613|Chromatiales	S	PFAM Hemerythrin HHE	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
k59_673398_2	765913.ThidrDRAFT_3383	3.8e-111	340.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,1RR35@1236|Gammaproteobacteria,1WXAB@135613|Chromatiales	135613|Chromatiales	P	TrkA-N domain	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_N
k59_1202048_1	1296415.JACC01000012_gene394	7.85e-06	53.9	COG4856@1|root,COG4856@2|Bacteria,4NHJQ@976|Bacteroidetes,1I0BY@117743|Flavobacteriia,2YIGQ@290174|Aquimarina	976|Bacteroidetes	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
k59_438109_1	590998.Celf_0545	5.17e-135	414.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2GKI9@201174|Actinobacteria,4F0N4@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8
k59_673403_1	1265313.HRUBRA_01474	9.57e-160	461.0	COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,1RS1U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	acetyltransferase	yghO	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	-
k59_673403_2	314264.ROS217_20127	7.39e-09	57.0	COG0746@1|root,COG0746@2|Bacteria,1QWF1@1224|Proteobacteria,2TWXS@28211|Alphaproteobacteria,46PA0@74030|Roseovarius	28211|Alphaproteobacteria	H	MobA-like NTP transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	HAD,NTP_transf_3
k59_276242_1	519989.ECTPHS_05325	8.75e-84	259.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1WW43@135613|Chromatiales	135613|Chromatiales	J	TIGRFAM Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_1552959_1	1288826.MSNKSG1_12307	2.88e-10	61.2	COG2859@1|root,COG2859@2|Bacteria,1QU0K@1224|Proteobacteria,1RR22@1236|Gammaproteobacteria,466G0@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09797	-	-	-	-	ko00000	-	-	-	SIMPL
k59_1501345_2	1335757.SPICUR_01600	2.38e-15	70.5	2EGIJ@1|root,33AAQ@2|Bacteria,1NH9B@1224|Proteobacteria,1SGKJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2909)	VL23_10685	-	-	-	-	-	-	-	-	-	-	-	DUF2909
k59_1501345_3	1123377.AUIV01000003_gene1768	1.54e-56	184.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1X3ZT@135614|Xanthomonadales	135614|Xanthomonadales	C	Heme copper-type cytochrome quinol oxidase subunit 3	cox3	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_1092737_1	247633.GP2143_09500	7.73e-60	196.0	COG2974@1|root,COG2974@2|Bacteria,1MXPR@1224|Proteobacteria,1RMNN@1236|Gammaproteobacteria,1J58F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	May be involved in recombination	rdgC	GO:0000018,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009295,GO:0019219,GO:0019222,GO:0031323,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363	-	ko:K03554	-	-	-	-	ko00000,ko03400	-	-	-	RdgC
k59_981111_1	743718.Isova_0175	6.67e-62	202.0	COG0628@1|root,COG0628@2|Bacteria,2GK0H@201174|Actinobacteria,4F492@85017|Promicromonosporaceae	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_393616_1	1267534.KB906754_gene3778	4.19e-92	280.0	COG0649@1|root,COG0649@2|Bacteria,3Y6MU@57723|Acidobacteria,2JKN7@204432|Acidobacteriia	204432|Acidobacteriia	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_1333315_1	644801.Psest_0483	9.29e-86	272.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1YZYX@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_614125_1	1234364.AMSF01000036_gene238	1.03e-158	464.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria,1X3QV@135614|Xanthomonadales	135614|Xanthomonadales	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.5.8.1,1.5.8.2	ko:K00317	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R01588,R02511	RC00185,RC00556,RC00557,RC00732	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
k59_1552968_1	363253.LI1051	2.5e-82	269.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2M8QH@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_276262_1	367299.JOEE01000014_gene932	4.73e-160	478.0	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,4FE8P@85021|Intrasporangiaceae	201174|Actinobacteria	S	UPF0182 protein	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_321048_2	765911.Thivi_4102	8.9e-60	193.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1WW30@135613|Chromatiales	135613|Chromatiales	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
k59_981123_1	1122194.AUHU01000010_gene3078	2.69e-27	106.0	COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,1S78U@1236|Gammaproteobacteria,467CR@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	NnrU protein	nnrU	-	-	-	-	-	-	-	-	-	-	-	NnrU
k59_1377022_2	1218076.BAYB01000021_gene3817	9.18e-15	80.1	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,2VJ1J@28216|Betaproteobacteria,1K3FH@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	czcD1	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_1501366_1	1121930.AQXG01000001_gene1203	6.52e-71	239.0	COG0841@1|root,COG0841@2|Bacteria,4NGCI@976|Bacteroidetes	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_849255_1	247490.KSU1_C1447	7.21e-120	370.0	COG0457@1|root,COG0457@2|Bacteria,2IXBT@203682|Planctomycetes	203682|Planctomycetes	C	deca-heme c-type cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_16,TPR_2,TPR_8
k59_732494_1	395963.Bind_2367	1.08e-29	114.0	COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,2VANG@28211|Alphaproteobacteria,3NBU0@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_849722_1	926550.CLDAP_31620	5.45e-26	105.0	COG0438@1|root,COG0438@2|Bacteria,2G75E@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
k59_849722_2	706587.Desti_0743	5.25e-58	182.0	COG0720@1|root,COG0720@2|Bacteria	2|Bacteria	H	synthase	queD	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
k59_673954_1	1121423.JONT01000010_gene1749	7.93e-35	129.0	COG0150@1|root,COG0150@2|Bacteria,1TP9J@1239|Firmicutes,248BT@186801|Clostridia,25ZYS@186807|Peptococcaceae	186801|Clostridia	F	PFAM AIR synthase related protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_204261_1	6500.XP_005108568.1	1.88e-75	226.0	COG5262@1|root,KOG1756@2759|Eukaryota,3A1K0@33154|Opisthokonta,3BQBZ@33208|Metazoa,3D75E@33213|Bilateria	33208|Metazoa	B	Histone H2A	-	GO:0000228,GO:0000785,GO:0000786,GO:0000788,GO:0000790,GO:0002376,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006325,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006955,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016043,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031974,GO:0031981,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0042742,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044815,GO:0045087,GO:0046483,GO:0050789,GO:0050794,GO:0050829,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051704,GO:0051707,GO:0051716,GO:0060255,GO:0065007,GO:0070013,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0098542,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K11251	ko04217,ko05034,ko05322,map04217,map05034,map05322	-	-	-	ko00000,ko00001,ko03036,ko04147	-	-	-	Histone,Histone_H2A_C
k59_1729999_1	686340.Metal_2791	1.09e-77	240.0	COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,1RP78@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the carbamate kinase family	arcC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	iE2348C_1286.E2348C_0454,iECED1_1282.ECED1_0540,iECUMN_1333.ECUMN_0561,iEcE24377_1341.EcE24377A_0559,iG2583_1286.G2583_0641,iJN746.PP_0999	AA_kinase
k59_1729999_2	1168034.FH5T_21325	1.03e-82	254.0	COG0078@1|root,COG0078@2|Bacteria,4NEYX@976|Bacteroidetes,2FPNE@200643|Bacteroidia	976|Bacteroidetes	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_277112_1	1121374.KB891575_gene1556	2.21e-51	177.0	COG0438@1|root,COG0438@2|Bacteria,1NE3V@1224|Proteobacteria,1RQE3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Catalyzes the addition of the first glucose residue to the LPS core	rfaG	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	iSDY_1059.SDY_4061	Glyco_transf_4,Glycos_transf_1
k59_1437657_1	396588.Tgr7_2778	1.21e-83	276.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales	135613|Chromatiales	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_394493_1	234831.PSM_A2548	7.21e-26	107.0	COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,1RREE@1236|Gammaproteobacteria,2Q16A@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	K	Transcriptional regulator	hdfR	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1140047_1	1267535.KB906767_gene3186	2.75e-14	73.9	COG1401@1|root,COG1401@2|Bacteria	2|Bacteria	V	restriction endodeoxyribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5,DUF3578,DUF3883
k59_1672590_1	313606.M23134_00574	5.74e-64	208.0	COG1509@1|root,COG1509@2|Bacteria,4NI73@976|Bacteroidetes,47U6T@768503|Cytophagia	976|Bacteroidetes	E	lysine 2,3-aminomutase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_981993_1	1048339.KB913029_gene1522	4.89e-71	235.0	COG4585@1|root,COG4585@2|Bacteria,2GIXR@201174|Actinobacteria,4EVA2@85013|Frankiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_981993_2	1122138.AQUZ01000047_gene66	3.97e-87	263.0	COG2197@1|root,COG2197@2|Bacteria,2GN29@201174|Actinobacteria,4DT7H@85009|Propionibacteriales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_981993_3	526225.Gobs_2302	6.38e-07	53.5	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4ERW2@85013|Frankiales	201174|Actinobacteria	G	SMART alpha amylase, catalytic sub domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_1862499_1	471853.Bcav_2426	2.64e-38	128.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria	201174|Actinobacteria	K	Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_1862499_2	1713.JOFV01000004_gene3366	5.26e-69	221.0	COG0421@1|root,COG0421@2|Bacteria,2GN8I@201174|Actinobacteria,4F2AK@85016|Cellulomonadaceae	201174|Actinobacteria	E	spermidine synthase	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Spermine_synth
k59_394500_2	1197719.A464_3810	6.62e-94	281.0	COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria,3ZJVS@590|Salmonella	1236|Gammaproteobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	GO:0000287,GO:0003674,GO:0003824,GO:0004588,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_2819,iECIAI39_1322.ECIAI39_4161,iEcSMS35_1347.EcSMS35_3977,iUTI89_1310.UTI89_C4186	Pribosyltran
k59_44100_1	326424.FRAAL4532	8.56e-23	95.5	COG2197@1|root,COG2197@2|Bacteria,2I8Y7@201174|Actinobacteria	201174|Actinobacteria	KT	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg,Sigma70_r4_2
k59_101013_1	1249627.D779_1328	1.2e-38	141.0	COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,1RPW5@1236|Gammaproteobacteria,1WW0X@135613|Chromatiales	135613|Chromatiales	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_101013_2	111781.Lepto7376_4035	8.09e-06	48.9	COG4948@1|root,COG4948@2|Bacteria,1G0R5@1117|Cyanobacteria,1H804@1150|Oscillatoriales	1117|Cyanobacteria	M	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C
k59_145700_1	935839.JAGJ01000001_gene1201	6.75e-66	212.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,4F3EK@85017|Promicromonosporaceae	201174|Actinobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0016740,GO:0016765,GO:0016829,GO:0016846	-	ko:K10764	ko00270,ko00920,ko01100,map00270,map00920,map01100	-	R01288	RC00020,RC02848	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0391	Cys_Met_Meta_PP
k59_145700_2	1713.JOFV01000006_gene2620	1.06e-27	103.0	COG0607@1|root,COG0607@2|Bacteria,2IN3Q@201174|Actinobacteria,4F2KC@85016|Cellulomonadaceae	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_922952_1	565045.NOR51B_72	1.08e-18	91.3	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1RQJX@1236|Gammaproteobacteria,1J8RS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	Q	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
k59_145701_1	713586.KB900536_gene118	4.73e-144	421.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1WWJ8@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_1202607_1	1349820.M707_07835	1.15e-162	459.0	COG0463@1|root,COG0463@2|Bacteria,2IPT1@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
k59_1202607_2	1349820.M707_07830	3.14e-50	164.0	COG2246@1|root,COG2246@2|Bacteria,2GT0Q@201174|Actinobacteria	201174|Actinobacteria	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
k59_982019_2	740709.A10D4_05212	3.14e-20	88.2	29EG8@1|root,334DW@2|Bacteria,1NFZA@1224|Proteobacteria,1SCN3@1236|Gammaproteobacteria,2QGT7@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Capsule biosynthesis CapC	capC	-	-	ko:K22116	-	-	-	-	ko00000	-	-	-	Caps_synth_CapC
k59_1334226_1	196367.JNFG01000014_gene5288	3.76e-26	112.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,1K2W2@119060|Burkholderiaceae	28216|Betaproteobacteria	D	PFAM cell divisionFtsK SpoIIIE	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1862523_1	1192034.CAP_8329	4.54e-79	251.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,42MYA@68525|delta/epsilon subdivisions,2WKFB@28221|Deltaproteobacteria,2YWPS@29|Myxococcales	28221|Deltaproteobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
k59_1202612_1	96561.Dole_1776	4.32e-43	159.0	COG4191@1|root,COG4191@2|Bacteria,1R9AK@1224|Proteobacteria,42Q2G@68525|delta/epsilon subdivisions,2WM8Y@28221|Deltaproteobacteria,2MI84@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_1437686_1	1206730.BAGA01000077_gene1082	5.62e-79	253.0	COG1155@1|root,COG1155@2|Bacteria,2HESQ@201174|Actinobacteria,4G5PD@85025|Nocardiaceae	201174|Actinobacteria	C	ATPsynthase alpha/beta subunit N-term extension	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_277171_1	870187.Thini_0278	2.96e-92	283.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,4637B@72273|Thiotrichales	72273|Thiotrichales	C	Fe-S oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_732541_1	1416759.AYMR01000009_gene2896	6.81e-19	90.1	COG4292@1|root,COG4292@2|Bacteria,2GJPB@201174|Actinobacteria,4FN9P@85023|Microbacteriaceae	201174|Actinobacteria	S	Bacterial low temperature requirement A protein (LtrA)	-	-	-	-	-	-	-	-	-	-	-	-	LtrA
k59_394540_1	264198.Reut_B5566	8.1e-25	106.0	COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,2VN9P@28216|Betaproteobacteria	28216|Betaproteobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_786663_1	1304865.JAGF01000001_gene3857	1.05e-178	531.0	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4F11C@85016|Cellulomonadaceae	201174|Actinobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_1553497_1	1123257.AUFV01000020_gene2075	1.39e-49	175.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,1RN57@1236|Gammaproteobacteria,1X48I@135614|Xanthomonadales	135614|Xanthomonadales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
k59_1553497_2	1335757.SPICUR_01275	2.44e-06	48.5	COG0475@1|root,COG0490@1|root,COG1226@1|root,COG0475@2|Bacteria,COG0490@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1WX9W@135613|Chromatiales	135613|Chromatiales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
k59_1611668_1	933262.AXAM01000014_gene261	4.03e-29	117.0	COG0475@1|root,COG0475@2|Bacteria,1R9PF@1224|Proteobacteria,42RF1@68525|delta/epsilon subdivisions,2WMJJ@28221|Deltaproteobacteria,2MJ88@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,PTS_EIIA_2,TrkA_C,TrkA_N
k59_614663_1	795797.C497_04707	1.48e-17	85.9	COG0604@1|root,arCOG01458@2157|Archaea,2XU0Q@28890|Euryarchaeota,23SPC@183963|Halobacteria	183963|Halobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	qor1	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1334247_1	864069.MicloDRAFT_00065020	3.08e-83	259.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2TSBN@28211|Alphaproteobacteria,1JRMP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
k59_277185_1	290400.Jann_3819	4.2e-56	191.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQNH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1140077_1	583355.Caka_0348	1.83e-72	239.0	COG0243@1|root,COG0243@2|Bacteria,46THY@74201|Verrucomicrobia,3K8KW@414999|Opitutae	414999|Opitutae	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_101066_2	1944.JOAZ01000012_gene6099	1.5e-29	117.0	COG0475@1|root,COG0475@2|Bacteria,2GJ69@201174|Actinobacteria,419PE@629295|Streptomyces griseus group	201174|Actinobacteria	P	Sodium/hydrogen exchanger family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
k59_394558_1	595460.RRSWK_00054	1.61e-126	378.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_394558_2	1232683.ADIMK_3982	7.59e-88	266.0	COG0406@1|root,COG0406@2|Bacteria,1RA6X@1224|Proteobacteria,1S7GE@1236|Gammaproteobacteria,46AT3@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_44169_1	1136417.AZWE01000096_gene4214	7.07e-17	78.6	COG0191@1|root,COG0191@2|Bacteria,2GM5P@201174|Actinobacteria,4D9MX@85008|Micromonosporales	201174|Actinobacteria	G	Fructose-bisphosphate aldolase	fba	GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
k59_1028492_1	1156919.QWC_30208	1.26e-107	317.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJM6@28216|Betaproteobacteria,3T22A@506|Alcaligenaceae	28216|Betaproteobacteria	E	ABC-type branched-chain amino acid transport systems ATPase component	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_1028492_2	443598.AUFA01000027_gene1913	3.02e-07	52.4	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TVNK@28211|Alphaproteobacteria,3JWUV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C
k59_1737585_1	95619.PM1_0216715	4.86e-83	263.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	GO:0000166,GO:0001716,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008734,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0015922,GO:0016491,GO:0016638,GO:0016641,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044318,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2574,iBWG_1329.BWG_2338,iECDH10B_1368.ECDH10B_2742,iECDH1ME8569_1439.ECDH1ME8569_2501,iETEC_1333.ETEC_2787,iEcDH1_1363.EcDH1_1094,iJO1366.b2574,iJR904.b2574,iLF82_1304.LF82_1433,iNRG857_1313.NRG857_12785,iY75_1357.Y75_RS13445,iYL1228.KPN_02899	FAD_binding_2,Succ_DH_flav_C
k59_681819_1	1126627.BAWE01000005_gene6111	1.86e-09	68.9	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_1346264_1	1049564.TevJSym_aa01930	1.27e-142	441.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1385446_1	78245.Xaut_0840	1.11e-33	125.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,3EYMA@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	MA20_18095	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1385446_2	666684.AfiDRAFT_2471	1.97e-06	47.4	COG5509@1|root,COG5509@2|Bacteria,1NG8P@1224|Proteobacteria,2UJB2@28211|Alphaproteobacteria,3K0WS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1192)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1192
k59_1561211_2	1458275.AZ34_15575	2.06e-14	76.6	COG1011@1|root,COG1011@2|Bacteria,1Q69Z@1224|Proteobacteria,2VQKJ@28216|Betaproteobacteria,4ADK0@80864|Comamonadaceae	28216|Betaproteobacteria	S	HaD-superfamily hydrolase, subfamily ia, variant 3	-	-	3.1.3.10	ko:K07025,ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_1561211_3	153948.NAL212_0823	1.94e-56	178.0	COG3169@1|root,COG3169@2|Bacteria,1RHBQ@1224|Proteobacteria,2VSWS@28216|Betaproteobacteria,373DM@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Putative member of DMT superfamily (DUF486)	-	-	-	ko:K09922	-	-	-	-	ko00000	-	-	-	DMT_6
k59_329292_1	384676.PSEEN3818	5.72e-08	56.2	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	fleR	-	-	ko:K10943	ko02020,ko05111,map02020,map05111	M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_857181_1	590998.Celf_0460	7.77e-127	372.0	COG0484@1|root,COG0484@2|Bacteria,2GJKK@201174|Actinobacteria,4F111@85016|Cellulomonadaceae	201174|Actinobacteria	O	SMART heat shock protein DnaJ domain protein	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_857181_2	222534.KB893714_gene1619	0.00033	42.0	COG0789@1|root,COG0789@2|Bacteria,2IQJ4@201174|Actinobacteria,4ET08@85013|Frankiales	201174|Actinobacteria	K	transcriptional regulator, MerR	hspR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
k59_1680147_1	187272.Mlg_2413	1.57e-08	54.7	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,1RPJA@1236|Gammaproteobacteria,1WWXR@135613|Chromatiales	135613|Chromatiales	S	Predicted integral membrane protein (DUF2189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2189
k59_1680147_2	742741.HMPREF9475_00869	1.43e-07	56.6	COG2358@1|root,COG2358@2|Bacteria,1TPXW@1239|Firmicutes,2489U@186801|Clostridia	186801|Clostridia	S	TRAP transporter solute receptor, TAXI family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
k59_153592_1	1321775.HMPREF1980_02116	1.09e-26	116.0	COG4733@1|root,COG4733@2|Bacteria,2GMKC@201174|Actinobacteria,4D31Y@85005|Actinomycetales	201174|Actinobacteria	S	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	fn3
k59_153592_2	1095767.CAHD01000012_gene943	5.27e-126	365.0	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4F25J@85016|Cellulomonadaceae	201174|Actinobacteria	O	Belongs to the peptidase M48B family	htpX	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_112930_1	439235.Dalk_0052	4.69e-103	326.0	COG0531@1|root,COG3064@1|root,COG0531@2|Bacteria,COG3064@2|Bacteria,1R4IZ@1224|Proteobacteria,42MTQ@68525|delta/epsilon subdivisions,2WK39@28221|Deltaproteobacteria,2MIIG@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,SLC12
k59_993907_1	710696.Intca_3342	6.06e-66	227.0	2EZYF@1|root,33T2N@2|Bacteria,2H3P5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1445182_1	493475.GARC_2896	9.1e-30	122.0	COG4251@1|root,COG5002@1|root,COG4251@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HATPase_c,HisKA,PAS,PAS_9
k59_1209934_1	998674.ATTE01000001_gene497	9.24e-100	316.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,4608B@72273|Thiotrichales	72273|Thiotrichales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_446329_1	1122194.AUHU01000011_gene1668	3.42e-16	80.5	COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,1RRWP@1236|Gammaproteobacteria,465RQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	COG0811 Biopolymer transport proteins	aglR	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
k59_993910_1	1172180.KB911792_gene3697	9.87e-99	299.0	COG1156@1|root,COG1156@2|Bacteria,2GKPJ@201174|Actinobacteria	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_287572_1	1532557.JL37_23750	1.37e-95	293.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2VPYJ@28216|Betaproteobacteria,3T6MT@506|Alcaligenaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_112961_1	1304865.JAGF01000001_gene2026	6.65e-93	280.0	COG0600@1|root,COG0600@2|Bacteria,2GIWG@201174|Actinobacteria,4F27F@85016|Cellulomonadaceae	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	ssuC3	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_681856_1	189753.AXAS01000006_gene2401	1.27e-37	151.0	COG0840@1|root,COG2770@1|root,COG0840@2|Bacteria,COG2770@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,3JSAR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	NT	Double sensory domain of two-component sensor kinase	MA20_04120	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_3
k59_681857_1	626887.J057_07631	1.54e-106	321.0	COG1653@1|root,COG1653@2|Bacteria,1MX9J@1224|Proteobacteria,1RPYT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	ABC transporter substrate-binding protein	thuE	-	-	ko:K10236	ko02010,map02010	M00204	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.17	-	-	SBP_bac_1,SBP_bac_8
k59_740516_1	1454004.AW11_03649	1.62e-62	206.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2VHBA@28216|Betaproteobacteria	28216|Betaproteobacteria	S	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_681859_1	1267005.KB911255_gene2440	4.32e-48	169.0	COG0810@1|root,COG1432@1|root,COG0810@2|Bacteria,COG1432@2|Bacteria,1Q0F0@1224|Proteobacteria,2UC1N@28211|Alphaproteobacteria,3N8A0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
k59_1028574_1	880072.Desac_2370	1.31e-70	225.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MG3@68525|delta/epsilon subdivisions,2WKC7@28221|Deltaproteobacteria,2MQ7Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	COGs COG0767 ABC-type transport system involved in resistance to organic solvents permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_1028574_2	1121438.JNJA01000002_gene3659	3.69e-23	94.7	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NTG@68525|delta/epsilon subdivisions,2WKHW@28221|Deltaproteobacteria,2M8FK@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	PFAM ABC transporter related	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_153623_1	566466.NOR53_3333	3.67e-18	86.3	COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S9SC@1236|Gammaproteobacteria,1J9DX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function, DUF484	yigA	-	-	ko:K09921	-	-	-	-	ko00000	-	-	-	DUF484
k59_153623_2	935863.AWZR01000002_gene1031	2.51e-55	185.0	COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1X31C@135614|Xanthomonadales	135614|Xanthomonadales	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1737635_1	247633.GP2143_07819	1.56e-12	73.6	COG2982@1|root,COG2982@2|Bacteria,1N0N6@1224|Proteobacteria,1S89P@1236|Gammaproteobacteria,1JBN9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1737635_2	458817.Shal_1728	2.03e-35	128.0	COG0625@1|root,COG0625@2|Bacteria,1RD2G@1224|Proteobacteria,1S3TT@1236|Gammaproteobacteria,2Q8KG@267890|Shewanellaceae	1236|Gammaproteobacteria	O	Glutathione S-transferase	-	-	-	-	-	-	-	-	-	-	-	-	GST_C,GST_C_2,GST_N_3
k59_1874575_1	323261.Noc_1663	4.53e-153	442.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1WWGC@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1510592_1	590998.Celf_2024	1.11e-144	430.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4F0M3@85016|Cellulomonadaceae	201174|Actinobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1874586_1	580332.Slit_2413	9.48e-114	351.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,44V9P@713636|Nitrosomonadales	28216|Betaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_153636_1	85643.Tmz1t_0677	0.000638	41.6	COG4314@1|root,COG4314@2|Bacteria,1N43A@1224|Proteobacteria,2VQI4@28216|Betaproteobacteria,2KWIY@206389|Rhodocyclales	206389|Rhodocyclales	C	lipoprotein involved in nitrous oxide reduction	-	-	-	-	-	-	-	-	-	-	-	-	NosL
k59_1794023_1	118166.JH976537_gene586	3.42e-34	132.0	COG2239@1|root,COG2239@2|Bacteria,1G0CN@1117|Cyanobacteria,1H8JS@1150|Oscillatoriales	1117|Cyanobacteria	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_287631_1	1408428.JNJP01000068_gene1267	3.03e-38	146.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2M859@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
k59_1619475_1	1500259.JQLD01000004_gene1113	0.000619	48.1	COG0790@1|root,COG1196@1|root,COG3170@1|root,COG3409@1|root,COG0790@2|Bacteria,COG1196@2|Bacteria,COG3170@2|Bacteria,COG3409@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,4B8SF@82115|Rhizobiaceae	28211|Alphaproteobacteria	DM	FOG TPR repeat, SEL1 subfamily	-	-	-	ko:K07126,ko:K13582	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	PG_binding_1,Sel1
k59_54761_1	1415780.JPOG01000001_gene1146	1.08e-103	320.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1X4EZ@135614|Xanthomonadales	135614|Xanthomonadales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_287639_1	1049564.TevJSym_af00530	7.56e-59	202.0	28K74@1|root,2Z9VA@2|Bacteria,1R8MQ@1224|Proteobacteria,1SKKZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_857237_1	1713.JOFV01000001_gene1958	3.14e-57	183.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4F0T8@85016|Cellulomonadaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	regX3	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_857237_2	1463857.JOFZ01000009_gene6231	9.19e-44	157.0	COG5002@1|root,COG5002@2|Bacteria,2GJY7@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	senX3	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:1901564	2.7.13.3	ko:K07768	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_792838_1	1137268.AZXF01000013_gene1692	9.07e-15	74.7	COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria,4EJT5@85012|Streptosporangiales	201174|Actinobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_792838_2	33876.JNXY01000061_gene9531	2.44e-10	67.4	COG5433@1|root,COG5433@2|Bacteria,2H2QB@201174|Actinobacteria,4DH3Y@85008|Micromonosporales	201174|Actinobacteria	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_1385513_1	1227739.Hsw_0527	6.1e-84	268.0	COG1009@1|root,COG1009@2|Bacteria,4NEBM@976|Bacteroidetes,47M8Q@768503|Cytophagia	976|Bacteroidetes	CP	NADH ubiquinone oxidoreductase subunit 5 (Chain L) multisubunit Na H antiporter, MnhA subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
k59_1276392_1	379066.GAU_1720	3.68e-33	126.0	COG0159@1|root,COG0159@2|Bacteria,1ZSYU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_792844_1	926561.KB900617_gene1658	3.18e-06	50.1	COG0810@1|root,COG0810@2|Bacteria,1VN7X@1239|Firmicutes,25413@186801|Clostridia,3WC1R@53433|Halanaerobiales	186801|Clostridia	M	TIGRFAM TonB family protein	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
k59_1511467_1	1211114.ALIP01000140_gene2354	1.48e-96	311.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,1RSHX@1236|Gammaproteobacteria,1X3T3@135614|Xanthomonadales	135614|Xanthomonadales	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_154594_1	504472.Slin_1574	1.09e-94	305.0	COG4409@1|root,COG4447@1|root,COG4409@2|Bacteria,COG4447@2|Bacteria,4NK01@976|Bacteroidetes,47NT3@768503|Cytophagia	976|Bacteroidetes	G	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_1347707_1	870187.Thini_0937	0.000318	43.9	COG1247@1|root,COG1247@2|Bacteria,1NZ6C@1224|Proteobacteria,1SPXX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
k59_1347707_2	2340.JV46_08070	7.93e-89	276.0	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,1RMC0@1236|Gammaproteobacteria,1J54W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	gor	GO:0000166,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071949,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	iZ_1308.Z4900	Pyr_redox_2,Pyr_redox_dim
k59_447332_1	743718.Isova_0600	1.32e-100	306.0	COG1721@1|root,COG1721@2|Bacteria,2GIWE@201174|Actinobacteria,4F40S@85017|Promicromonosporaceae	201174|Actinobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_1029829_1	446466.Cfla_0704	9.43e-97	288.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	urtE	-	-	ko:K11963	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran
k59_1681045_2	743718.Isova_1980	0.000645	41.2	COG1420@1|root,COG1420@2|Bacteria,2GKF5@201174|Actinobacteria,4F3YS@85017|Promicromonosporaceae	201174|Actinobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HTH_DeoR,HrcA
k59_1347714_1	1232683.ADIMK_0193	3.56e-07	52.4	COG1773@1|root,COG1773@2|Bacteria,1MV2U@1224|Proteobacteria,1S2ZY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	PFAM HupH hydrogenase expression protein, C-terminal conserved region	hyaF	-	-	ko:K03618	-	-	-	-	ko00000	-	-	-	HupH_C,Rubredoxin
k59_1347714_2	652103.Rpdx1_0497	8.01e-15	73.9	COG0526@1|root,COG0526@2|Bacteria,1RJ41@1224|Proteobacteria,2TX76@28211|Alphaproteobacteria,3K1M7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CO	Hydrogenase-1 expression protein HyaE	-	-	-	ko:K03619	-	-	-	-	ko00000	-	-	-	HyaE
k59_1347714_3	1038867.AXAY01000017_gene1569	3.06e-10	58.9	COG0298@1|root,COG0298@2|Bacteria,1N9Z3@1224|Proteobacteria,2UD4G@28211|Alphaproteobacteria,3JZS3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	HupF/HypC family	hupF	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
k59_935937_1	1121405.dsmv_3691	4.35e-120	352.0	COG3547@1|root,COG3547@2|Bacteria,1NP2U@1224|Proteobacteria,43A5Q@68525|delta/epsilon subdivisions,2X2AM@28221|Deltaproteobacteria,2MPDW@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_505998_1	338963.Pcar_1272	4.88e-09	53.5	COG3952@1|root,COG3952@2|Bacteria,1MZ60@1224|Proteobacteria,42V3D@68525|delta/epsilon subdivisions,2WS7J@28221|Deltaproteobacteria,43VH8@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Lipid A Biosynthesis N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	LAB_N
k59_505998_2	292415.Tbd_1534	5.14e-34	132.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria,1KRDI@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_447341_1	593907.Celgi_1655	1.56e-101	303.0	COG1354@1|root,COG1354@2|Bacteria,2GN1U@201174|Actinobacteria,4F0HZ@85016|Cellulomonadaceae	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
k59_1029844_1	266117.Rxyl_2842	3.31e-22	91.7	COG0590@1|root,COG0590@2|Bacteria,2I9KR@201174|Actinobacteria	201174|Actinobacteria	FJ	CMP dCMP deaminase, zinc-binding	-	-	-	-	-	-	-	-	-	-	-	-	dCMP_cyt_deam_1
k59_1029844_2	1535422.ND16A_1819	2.87e-39	140.0	COG0388@1|root,COG0388@2|Bacteria,1MWQG@1224|Proteobacteria,1RYY7@1236|Gammaproteobacteria,2Q85K@267889|Colwelliaceae	1236|Gammaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.5.7	ko:K01502	ko00643,ko01120,map00643,map01120	-	R05358	RC01336	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
k59_793565_1	999419.HMPREF1077_00177	2.69e-14	77.4	COG0436@1|root,COG0436@2|Bacteria,4NENS@976|Bacteroidetes,2FMU2@200643|Bacteroidia,22VY5@171551|Porphyromonadaceae	976|Bacteroidetes	E	Aminotransferase	aspC	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_407889_1	1454010.JEOE01000001_gene610	4.05e-97	294.0	COG2805@1|root,COG2805@2|Bacteria,2I9GT@201174|Actinobacteria	201174|Actinobacteria	NU	twitching motility protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_1446062_1	644283.Micau_4943	9.07e-49	168.0	COG3844@1|root,COG3844@2|Bacteria,2GMJQ@201174|Actinobacteria,4DBYN@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
k59_1633261_1	1123359.AUIQ01000111_gene594	1.13e-22	90.9	arCOG05874@1|root,2ZJ01@2|Bacteria,1V450@1239|Firmicutes,4HFPA@91061|Bacilli,4B2MY@81852|Enterococcaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_167168_1	998674.ATTE01000001_gene587	1.95e-16	75.1	COG1463@1|root,COG1463@2|Bacteria,1RHH6@1224|Proteobacteria,1S74Q@1236|Gammaproteobacteria,4614U@72273|Thiotrichales	72273|Thiotrichales	Q	Protein of unknown function (DUF3465)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3465
k59_167168_2	1121939.L861_18550	4.48e-44	149.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,1XIJW@135619|Oceanospirillales	135619|Oceanospirillales	H	catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
k59_1398645_1	1236973.JCM9157_2144	5.01e-52	182.0	COG0624@1|root,COG0624@2|Bacteria,1TPSM@1239|Firmicutes,4HD69@91061|Bacilli,1ZDSF@1386|Bacillus	91061|Bacilli	E	Peptidase dimerisation domain	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1633274_1	1528098.NOVO_03665	4.35e-11	67.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria,47F0K@766|Rickettsiales	766|Rickettsiales	T	response regulator containing a CheY-like receiver domain and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_871662_1	1279017.AQYJ01000022_gene2609	9.59e-47	163.0	COG1196@1|root,COG1196@2|Bacteria,1R4BS@1224|Proteobacteria,1S13B@1236|Gammaproteobacteria,466JA@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_1694043_1	765910.MARPU_04395	7.99e-84	270.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM NADH-quinone oxidoreductase, chain G	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1633286_1	85643.Tmz1t_0362	3.5e-120	367.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VHHZ@28216|Betaproteobacteria,2KUV3@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.3	ko:K07306	ko00920,map00920	-	R09501	RC02555	ko00000,ko00001,ko01000,ko02000	5.A.3.3	-	-	Molybdopterin,Molydop_binding
k59_167182_1	367299.JOEE01000002_gene2378	1.63e-127	387.0	COG1276@1|root,COG3336@1|root,COG1276@2|Bacteria,COG3336@2|Bacteria,2GKIR@201174|Actinobacteria,4FFHN@85021|Intrasporangiaceae	201174|Actinobacteria	P	Cytochrome C oxidase assembly protein	-	-	-	ko:K02351,ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	Caa3_CtaG,CopD
k59_1158479_1	1123257.AUFV01000009_gene2252	8.45e-101	304.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,1X4BJ@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_1575104_1	686340.Metal_1564	1.23e-81	259.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,1RQ9W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	to Escherichia coli transposase for insertion sequence element IS21 IstA SW ISTA_ECOLI (P15025) (390 aa) fasta scores E() 3e-27, 33.1 id in 329 aa. Identical to the previously sequenced Yersinia pestis,Yersinia pseudotuberculosis and Escherichia coli pesticin plasmid insertion sequence transposase Y1055 TR P74993 (EMBL U59875) (340 aa) fasta scores E() 0, 100.0 id in 340 aa	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,rve
k59_871676_1	1303518.CCALI_01905	2.59e-63	206.0	COG0499@1|root,COG0499@2|Bacteria	2|Bacteria	H	adenosylhomocysteinase activity	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_516792_1	867903.ThesuDRAFT_01269	1.48e-78	259.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,3WCCN@538999|Clostridiales incertae sedis	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_803084_1	768066.HELO_1585	1.03e-54	184.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1XI29@135619|Oceanospirillales	135619|Oceanospirillales	C	Glycolate oxidase	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7,Fer4_8
k59_803084_2	1279017.AQYJ01000027_gene1576	6.24e-12	66.2	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,465W6@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Rhodanese Homology Domain	rhdA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_1044304_1	1249627.D779_3945	2.2e-52	184.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1WWCN@135613|Chromatiales	135613|Chromatiales	S	Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
k59_458692_1	10224.XP_006817261.1	3.44e-36	140.0	2D1AE@1|root,2SHBM@2759|Eukaryota,3AFP7@33154|Opisthokonta,3BY0Y@33208|Metazoa,3DET1@33213|Bilateria	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17
k59_458697_1	1049564.TevJSym_ad00510	5.47e-96	282.0	COG0650@1|root,COG0650@2|Bacteria,1QE37@1224|Proteobacteria,1RZJC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	pfam nadh	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_1694096_2	225937.HP15_352	1.7e-49	169.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria,464RI@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iSSON_1240.SSON_4131	Semialdhyde_dh,Semialdhyde_dhC
k59_1575151_1	349163.Acry_1286	6.21e-12	62.8	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2TU72@28211|Alphaproteobacteria,2JQ3I@204441|Rhodospirillales	204441|Rhodospirillales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_1575151_2	1480694.DC28_13180	2.42e-41	139.0	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_458710_1	1123368.AUIS01000026_gene1452	1.72e-73	242.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,2NCIN@225057|Acidithiobacillales	225057|Acidithiobacillales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,zinc_ribbon_12
k59_694798_1	631362.Thi970DRAFT_02745	4.57e-115	365.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1WXIK@135613|Chromatiales	135613|Chromatiales	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_167236_1	1169161.KB897719_gene3528	1.72e-31	124.0	COG0673@1|root,COG0673@2|Bacteria,2I102@201174|Actinobacteria	201174|Actinobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_871734_1	1121434.AULY01000006_gene775	6.01e-13	71.2	COG2373@1|root,COG2373@2|Bacteria,1QUMU@1224|Proteobacteria,43BME@68525|delta/epsilon subdivisions,2X6ZK@28221|Deltaproteobacteria,2MH9B@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Large extracellular alpha-helical protein	-	-	-	ko:K16915	ko02010,map02010	M00246	-	-	ko00000,ko00001,ko00002,ko02000	-	-	-	-
k59_871734_2	879212.DespoDRAFT_01740	6.37e-07	50.1	COG0619@1|root,COG0619@2|Bacteria,1RJIT@1224|Proteobacteria,42RU5@68525|delta/epsilon subdivisions,2WNB7@28221|Deltaproteobacteria,2MJTN@213118|Desulfobacterales	28221|Deltaproteobacteria	P	TIGRFAM cobalt ABC transporter, permease protein CbiQ	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
k59_1575176_2	1279019.ARQK01000057_gene794	4.67e-13	72.8	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1WXP3@135613|Chromatiales	135613|Chromatiales	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_1044373_1	1117319.PSPO_04032	2.88e-11	68.9	COG3568@1|root,COG3568@2|Bacteria,1RGY4@1224|Proteobacteria,1T244@1236|Gammaproteobacteria,2Q5FT@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_576039_1	207559.Dde_1960	5.22e-30	122.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42M01@68525|delta/epsilon subdivisions,2WJ7M@28221|Deltaproteobacteria,2M94I@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	ABC transporter, transmembrane region	msbA	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1575187_1	1384054.N790_10750	5.82e-22	101.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1X4NS@135614|Xanthomonadales	135614|Xanthomonadales	M	Lytic murein transglycosylase	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
k59_1223857_1	1042375.AFPL01000022_gene2621	6.86e-22	99.0	COG0639@1|root,COG0639@2|Bacteria,1MUV1@1224|Proteobacteria,1RPFZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
k59_803143_1	313589.JNB_04140	0.000261	42.4	COG0703@1|root,COG0703@2|Bacteria,2GRFW@201174|Actinobacteria,4FGP3@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
k59_803143_2	1454010.JEOE01000001_gene620	1.75e-217	608.0	COG0082@1|root,COG0082@2|Bacteria,2GJJN@201174|Actinobacteria,4F0Y0@85016|Cellulomonadaceae	201174|Actinobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2540c	Chorismate_synt
k59_1044391_1	367299.JOEE01000007_gene81	1.53e-103	303.0	COG2197@1|root,COG2197@2|Bacteria,2GIVA@201174|Actinobacteria,4FEB1@85021|Intrasporangiaceae	201174|Actinobacteria	K	LuxR family transcriptional regulator	tcsR3	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1633382_1	768671.ThimaDRAFT_3073	5.43e-66	206.0	COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,1RMEM@1236|Gammaproteobacteria,1WXQ7@135613|Chromatiales	135613|Chromatiales	E	ABC transporter	-	-	-	ko:K11963	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran
k59_1633382_2	2340.JV46_28560	3.43e-22	92.8	COG0829@1|root,COG0829@2|Bacteria,1RABD@1224|Proteobacteria,1RSB2@1236|Gammaproteobacteria,1J67E@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureD	-	-	ko:K03190	-	-	-	-	ko00000	-	-	-	UreD
k59_1805414_1	1234664.AMRO01000003_gene636	9.17e-42	154.0	COG0144@1|root,COG3270@1|root,COG0144@2|Bacteria,COG3270@2|Bacteria,1TPGQ@1239|Firmicutes,4HCHQ@91061|Bacilli,1WE71@129337|Geobacillus	91061|Bacilli	J	RNA-binding PUA-like domain of methyltransferase RsmF	rsmF	-	-	-	-	-	-	-	-	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,Methyltranf_PUA,RsmF_methylt_CI
k59_1398759_1	1236541.BALL01000025_gene3012	8.26e-62	208.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,2QA0M@267890|Shewanellaceae	1236|Gammaproteobacteria	O	Molecular chaperone. Has ATPase activity	htpG	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006974,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
k59_1223871_1	1165841.SULAR_01563	1.82e-112	334.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42Z0P@68525|delta/epsilon subdivisions,2YR4F@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	L	COG0513 Superfamily II DNA and RNA	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_1805417_2	1279019.ARQK01000049_gene10	2.18e-15	73.9	COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria,1WZWK@135613|Chromatiales	135613|Chromatiales	G	pfkB family carbohydrate kinase	-	-	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_635115_1	1122933.JNIY01000003_gene817	2.33e-122	356.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
k59_1694162_1	1283283.ATXA01000004_gene4289	2.26e-98	307.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sulfatase	atsB	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF1269,Sulfatase
k59_342993_1	1249627.D779_0855	0.0	1337.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales	135613|Chromatiales	E	glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_225417_1	768671.ThimaDRAFT_2343	2.21e-105	318.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1WWBG@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_803176_1	335543.Sfum_1377	4.29e-98	296.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,42M0T@68525|delta/epsilon subdivisions,2WJ3C@28221|Deltaproteobacteria,2MQ7Z@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_1633418_1	1158338.JNLJ01000005_gene1523	7.72e-26	106.0	COG3264@1|root,COG3264@2|Bacteria,2G3QD@200783|Aquificae	200783|Aquificae	M	Mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
k59_1633418_2	1270193.JARP01000001_gene2277	1.13e-29	114.0	COG3384@1|root,COG3384@2|Bacteria,4NFGT@976|Bacteroidetes,1HX1P@117743|Flavobacteriia,2NS8H@237|Flavobacterium	976|Bacteroidetes	S	in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
k59_1044448_1	1121438.JNJA01000023_gene366	3.2e-20	96.3	COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,42MA5@68525|delta/epsilon subdivisions,2WJGZ@28221|Deltaproteobacteria,2M9Y5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
k59_516876_2	591158.SSMG_05684	1.02e-58	207.0	COG0747@1|root,COG1123@1|root,COG0747@2|Bacteria,COG4172@2|Bacteria,2GJ9N@201174|Actinobacteria	201174|Actinobacteria	E	ABC-type dipeptide transport system, periplasmic component	oppA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1459166_1	1449347.JQLN01000005_gene4819	4.63e-26	109.0	COG0582@1|root,COG0582@2|Bacteria,2GISN@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
k59_1694199_1	1123393.KB891316_gene2122	1.48e-73	231.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2VJAS@28216|Betaproteobacteria,1KT21@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
k59_871836_1	742738.HMPREF9460_03855	1.07e-06	55.8	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,248W4@186801|Clostridia	186801|Clostridia	E	Family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_694880_1	867845.KI911784_gene733	4.25e-63	212.0	COG0151@1|root,COG0151@2|Bacteria,2G7M4@200795|Chloroflexi,377MJ@32061|Chloroflexia	32061|Chloroflexia	F	ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
k59_167336_1	1121396.KB893118_gene3101	1.48e-42	153.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria,2MJ57@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
k59_1223931_1	90813.JQMT01000001_gene1360	1.05e-58	197.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,4604V@72273|Thiotrichales	72273|Thiotrichales	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_694889_1	292459.STH1475	8.97e-18	80.9	COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia	186801|Clostridia	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
k59_576101_1	631362.Thi970DRAFT_03553	1.5e-117	364.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1WXD9@135613|Chromatiales	135613|Chromatiales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_1750897_1	631362.Thi970DRAFT_03247	7.95e-32	123.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1WWQM@135613|Chromatiales	135613|Chromatiales	P	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1750897_2	472759.Nhal_0923	1.49e-83	258.0	COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1WX1P@135613|Chromatiales	135613|Chromatiales	S	Cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
k59_1633452_1	483219.LILAB_17925	6.47e-53	177.0	COG1092@1|root,COG1092@2|Bacteria,1QW1V@1224|Proteobacteria,42Q3P@68525|delta/epsilon subdivisions,2WJXM@28221|Deltaproteobacteria,2YWQY@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the methyltransferase superfamily	-	-	2.1.1.173,2.1.1.191,2.1.1.264	ko:K06969,ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
k59_1805468_1	1265505.ATUG01000002_gene1700	3.16e-63	210.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,42N91@68525|delta/epsilon subdivisions,2WIMM@28221|Deltaproteobacteria,2MIKE@213118|Desulfobacterales	28221|Deltaproteobacteria	J	RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
k59_871877_1	748658.KB907315_gene2545	4.99e-65	208.0	COG0668@1|root,COG0668@2|Bacteria,1QU7U@1224|Proteobacteria,1T1Q9@1236|Gammaproteobacteria,1WZXW@135613|Chromatiales	135613|Chromatiales	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_458821_1	1032480.MLP_24880	2.08e-36	139.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,2I8V5@201174|Actinobacteria,4DQ2X@85009|Propionibacteriales	201174|Actinobacteria	P	Sodium/hydrogen exchanger family	kefB	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
k59_1158628_1	1267005.KB911256_gene1807	8.77e-124	382.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,3N67I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_1633464_1	999141.GME_00070	7.17e-39	147.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1XHCM@135619|Oceanospirillales	135619|Oceanospirillales	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_343054_1	258052.JNYV01000010_gene3251	6.02e-13	69.7	COG3544@1|root,COG3544@2|Bacteria,2IKUE@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF305
k59_1575315_1	273677.BW34_00861	3.95e-84	249.0	COG0100@1|root,COG0100@2|Bacteria,2IFFC@201174|Actinobacteria,4FNCF@85023|Microbacteriaceae	201174|Actinobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
k59_694921_1	177437.HRM2_02740	7.38e-44	154.0	COG0370@1|root,COG0370@2|Bacteria,1QWMI@1224|Proteobacteria,43BSF@68525|delta/epsilon subdivisions,2X739@28221|Deltaproteobacteria,2MI8F@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1398847_1	1265313.HRUBRA_01249	6.08e-28	117.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,1J5DJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	CoA binding domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1046718_2	1191523.MROS_1569	1.4e-38	145.0	COG0642@1|root,COG4191@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_636555_1	96561.Dole_0998	5.09e-98	303.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,42PSJ@68525|delta/epsilon subdivisions,2WJDD@28221|Deltaproteobacteria,2MHWQ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	reductase, alpha subunit	aprA	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
k59_696459_1	889378.Spiaf_2010	4.25e-70	229.0	COG0165@1|root,COG0165@2|Bacteria,2J5FG@203691|Spirochaetes	203691|Spirochaetes	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_1225797_1	1125863.JAFN01000001_gene3126	5.6e-68	220.0	COG5659@1|root,COG5659@2|Bacteria,1MWAV@1224|Proteobacteria,43BD6@68525|delta/epsilon subdivisions,2X6S2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_1635308_1	7668.SPU_026803-tr	6.46e-60	209.0	2D1AE@1|root,2SHBM@2759|Eukaryota,3AFP7@33154|Opisthokonta,3BY0Y@33208|Metazoa,3DET1@33213|Bilateria	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17
k59_1806875_1	648757.Rvan_0465	1.26e-106	320.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,2TSEA@28211|Alphaproteobacteria,3N6R0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
k59_1752306_1	709032.Sulku_0681	2.22e-90	277.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,42MJT@68525|delta/epsilon subdivisions,2YMEB@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_518068_1	314345.SPV1_01352	3.37e-16	77.4	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria	1224|Proteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_169137_1	640081.Dsui_2249	1.09e-78	258.0	COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,2VJBG@28216|Betaproteobacteria,2KW5F@206389|Rhodocyclales	206389|Rhodocyclales	T	Two-component sensor kinase N-terminal	-	-	2.7.13.3	ko:K07645	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
k59_1752320_1	1304885.AUEY01000036_gene2247	2.12e-117	353.0	COG0591@1|root,COG0591@2|Bacteria,1PNHU@1224|Proteobacteria,43AQ2@68525|delta/epsilon subdivisions,2X63U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_1696133_2	42565.FP66_12520	1.23e-14	75.5	COG2207@1|root,COG2207@2|Bacteria,1Q3UX@1224|Proteobacteria,1RS88@1236|Gammaproteobacteria,1XHJN@135619|Oceanospirillales	135619|Oceanospirillales	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K04033	-	-	-	-	ko00000,ko03000	-	-	-	HTH_18
k59_297986_1	743299.Acife_0890	2.4e-12	67.8	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1S1ID@1236|Gammaproteobacteria,2NC8Z@225057|Acidithiobacillales	225057|Acidithiobacillales	P	copper-translocating P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
k59_297986_2	1188252.AJYK01000069_gene2165	0.000402	45.1	COG5001@1|root,COG5001@2|Bacteria,1PHTE@1224|Proteobacteria,1RX7C@1236|Gammaproteobacteria,1Y0GM@135623|Vibrionales	135623|Vibrionales	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_9
k59_180430_1	1961.JOAK01000003_gene1375	1.58e-26	103.0	COG0454@1|root,COG0456@2|Bacteria,2GJJZ@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
k59_766904_1	96561.Dole_2701	2.97e-53	191.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2MIS4@213118|Desulfobacterales	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	ctpF	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_1588980_1	765912.Thimo_1968	1.3e-91	285.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1WW0Z@135613|Chromatiales	135613|Chromatiales	CI	TIGRFAM Oxaloacetate decarboxylase, alpha subunit	-	-	6.4.1.1	ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_591495_1	583355.Caka_2618	3.43e-63	205.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1061431_2	1415755.JQLV01000001_gene1419	4.83e-17	81.6	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,1XIC7@135619|Oceanospirillales	135619|Oceanospirillales	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	nirB	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
k59_1826350_1	550540.Fbal_3129	6.29e-20	91.7	COG0526@1|root,COG0526@2|Bacteria,1MWDE@1224|Proteobacteria,1S0NV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
k59_1826350_2	663278.Ethha_1631	1.56e-09	59.7	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,3WH82@541000|Ruminococcaceae	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_1237263_1	335543.Sfum_1913	1.18e-61	201.0	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,42RF4@68525|delta/epsilon subdivisions,2WPIV@28221|Deltaproteobacteria,2MRQ0@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	ROK family	glkA	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_1471990_1	1121403.AUCV01000045_gene1145	4.75e-26	102.0	2AVTU@1|root,31MME@2|Bacteria,1NQ7V@1224|Proteobacteria,42XCN@68525|delta/epsilon subdivisions,2WTFJ@28221|Deltaproteobacteria,2MNKH@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_946017_1	1121405.dsmv_3059	1.69e-67	225.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,42M6A@68525|delta/epsilon subdivisions,2WJIT@28221|Deltaproteobacteria,2MHVB@213118|Desulfobacterales	28221|Deltaproteobacteria	J	glycyl-tRNA synthetase, beta	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_1298228_1	1157943.KB892705_gene2164	8e-29	117.0	COG4584@1|root,COG4584@2|Bacteria,2GM4J@201174|Actinobacteria,2377M@1762|Mycobacteriaceae	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_473942_1	1538295.JY96_02750	2.73e-46	160.0	COG1575@1|root,COG1575@2|Bacteria	2|Bacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_1354511_1	335543.Sfum_3287	6.86e-60	202.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42M9D@68525|delta/epsilon subdivisions,2WJ43@28221|Deltaproteobacteria,2MQW5@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_5815_1	543632.JOJL01000119_gene275	4.83e-67	211.0	COG3267@1|root,COG3267@2|Bacteria,2IA4V@201174|Actinobacteria	201174|Actinobacteria	U	Type II secretory pathway component ExeA	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
k59_1472019_1	1121013.P873_02315	1.69e-31	122.0	COG1752@1|root,COG1752@2|Bacteria,1R7RX@1224|Proteobacteria,1RRTH@1236|Gammaproteobacteria,1X4R5@135614|Xanthomonadales	135614|Xanthomonadales	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_5824_1	1499967.BAYZ01000040_gene2249	1.23e-82	254.0	COG2230@1|root,COG2230@2|Bacteria	2|Bacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	cfa	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_1237825_1	519989.ECTPHS_00150	4.14e-66	214.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1WWQM@135613|Chromatiales	135613|Chromatiales	P	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_180937_2	1265313.HRUBRA_01328	2.97e-38	141.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1J4D3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	GO:0003674,GO:0003824,GO:0004794,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009081,GO:0009082,GO:0009097,GO:0009987,GO:0016053,GO:0016597,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0019842,GO:0030170,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_2699	PALP,Thr_dehydrat_C
k59_415530_2	1288079.AUKN01000018_gene2480	9.56e-122	372.0	2C9AC@1|root,2Z7TR@2|Bacteria,2I07F@201174|Actinobacteria	201174|Actinobacteria	S	Phage portal protein, SPP1 Gp6-like	-	-	-	-	-	-	-	-	-	-	-	-	Phage_prot_Gp6
k59_1354950_1	1043205.AFYF01000061_gene2785	8.54e-41	137.0	COG4113@1|root,COG4113@2|Bacteria,2GR4U@201174|Actinobacteria,4FHJX@85021|Intrasporangiaceae	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
k59_1354950_2	1385520.N802_03005	5.04e-29	106.0	2DPHS@1|root,3324E@2|Bacteria,2GT39@201174|Actinobacteria,4FHUC@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_826394_2	1214101.BN159_0356	1.16e-21	89.7	COG0599@1|root,COG0599@2|Bacteria,2IM93@201174|Actinobacteria	201174|Actinobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_1472672_1	1304865.JAGF01000001_gene3289	7.98e-16	70.9	COG0640@1|root,COG0640@2|Bacteria,2GQU5@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein, ArsR	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
k59_1472672_2	1304865.JAGF01000001_gene3288	4.46e-187	525.0	COG0701@1|root,COG0701@2|Bacteria	2|Bacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
k59_887832_1	2340.JV46_21960	1.83e-119	372.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5KS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_122223_2	325452.fgenesh_scip_prom.46568.2276	6.56e-33	134.0	COG0339@1|root,COG0363@1|root,COG0464@1|root,KOG0741@2759|Eukaryota,KOG2089@2759|Eukaryota,KOG3147@2759|Eukaryota,3Q96E@4776|Peronosporales	4776|Peronosporales	O	AAA domain (Cdc48 subfamily)	-	-	3.6.4.6	ko:K06027	ko04138,ko04721,ko04727,ko04962,map04138,map04721,map04727,map04962	-	-	-	ko00000,ko00001,ko01000,ko04131	1.F.1.1	-	-	AAA
k59_1827037_1	983545.Glaag_4274	1.12e-10	61.6	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,46440@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_1827037_2	883126.HMPREF9710_02404	7.81e-41	154.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4760P@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_9
k59_1237839_1	580332.Slit_1773	1.28e-75	236.0	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,2VMGT@28216|Betaproteobacteria	28216|Betaproteobacteria	GK	ROK family	nagK	-	2.7.1.2,2.7.1.4,2.7.1.59	ko:K00845,ko:K00847,ko:K00884	ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R00760,R00867,R01201,R01600,R01786,R03920	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_359498_1	795666.MW7_2248	3.99e-77	242.0	COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,2VHDV@28216|Betaproteobacteria,1K2HY@119060|Burkholderiaceae	1224|Proteobacteria	C	Dehydrogenase	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1472674_1	1304865.JAGF01000001_gene2802	5.9e-88	275.0	COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria,4F1NP@85016|Cellulomonadaceae	201174|Actinobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	iNJ661.Rv2992c	tRNA-synt_1c
k59_946718_1	338966.Ppro_1951	2.22e-28	110.0	COG1149@1|root,COG1149@2|Bacteria,1MVPB@1224|Proteobacteria,42MJ5@68525|delta/epsilon subdivisions,2WJ9M@28221|Deltaproteobacteria,43SV7@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
k59_946718_2	273068.TTE1860	2.27e-09	55.8	COG1918@1|root,COG1918@2|Bacteria,1UEM0@1239|Firmicutes,25JJM@186801|Clostridia,42HFY@68295|Thermoanaerobacterales	186801|Clostridia	P	FeoA family	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
k59_122225_1	589865.DaAHT2_0593	2.23e-12	76.6	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,1R8QH@1224|Proteobacteria,42T02@68525|delta/epsilon subdivisions,2WPNU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	PFAM WD40 domain protein beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,PD40
k59_6704_1	595537.Varpa_0266	2.37e-149	437.0	COG0644@1|root,COG0644@2|Bacteria,1MZ3Z@1224|Proteobacteria,2VIEH@28216|Betaproteobacteria,4AHDP@80864|Comamonadaceae	28216|Betaproteobacteria	C	Tryptophan halogenase	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
k59_946720_1	748247.AZKH_1105	6.09e-56	184.0	COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,2VKYR@28216|Betaproteobacteria,2KW1I@206389|Rhodocyclales	206389|Rhodocyclales	T	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
k59_946727_1	686578.AFFX01000008_gene2782	7.89e-76	240.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_1298945_1	446471.Xcel_0180	9.08e-74	232.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4F44C@85017|Promicromonosporaceae	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	fbpC	-	-	ko:K02052,ko:K02062	ko02010,ko02024,map02010,map02024	M00191,M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.19	-	-	ABC_tran,TOBE_2
k59_1298945_2	1304865.JAGF01000001_gene1465	1.94e-109	334.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria,4F25C@85016|Cellulomonadaceae	201174|Actinobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	thiP	-	-	ko:K02011,ko:K02063	ko02010,map02010	M00190,M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10,3.A.1.19	-	-	BPD_transp_1
k59_826411_1	1454010.JEOE01000039_gene2993	2.48e-84	263.0	COG1004@1|root,COG1004@2|Bacteria,2GJQB@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	rkpK	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_946728_1	1249627.D779_3980	1.92e-55	189.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1WW7V@135613|Chromatiales	135613|Chromatiales	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_1827065_2	1236959.BAMT01000005_gene70	1.18e-80	250.0	COG3185@1|root,COG3185@2|Bacteria,1R5AJ@1224|Proteobacteria,2W11Y@28216|Betaproteobacteria,2KKMU@206350|Nitrosomonadales	206350|Nitrosomonadales	E	4-Hydroxyphenylpyruvate dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1707238_1	1117647.M5M_01435	1.87e-63	202.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1J5E2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	MotA TolQ ExbB proton channel	exbB	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_1298964_1	1232683.ADIMK_2626	9.86e-33	121.0	COG0598@1|root,COG0598@2|Bacteria,1MWMP@1224|Proteobacteria,1RNDQ@1236|Gammaproteobacteria,465JG@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Mediates influx of magnesium ions	corA	GO:0000041,GO:0003674,GO:0005215,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0015075,GO:0015087,GO:0015095,GO:0015099,GO:0015318,GO:0015675,GO:0015693,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035444,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	iYL1228.KPN_04313	CorA
k59_1648818_1	765912.Thimo_2262	1.23e-48	164.0	COG1394@1|root,COG1394@2|Bacteria,1RJ1P@1224|Proteobacteria,1S75D@1236|Gammaproteobacteria,1WYND@135613|Chromatiales	135613|Chromatiales	C	ATP synthase subunit D	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
k59_1178894_1	404380.Gbem_3445	6.4e-21	93.2	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Methyltransf_11,Methyltransf_23,Methyltransf_25
k59_180974_1	1123508.JH636440_gene2736	1.12e-61	204.0	COG2223@1|root,COG2223@2|Bacteria,2IXT3@203682|Planctomycetes	203682|Planctomycetes	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1707246_1	96561.Dole_1729	6.79e-59	204.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,2MHQG@213118|Desulfobacterales	28221|Deltaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_1354981_1	228410.NE0431	3.84e-38	141.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2WAY9@28216|Betaproteobacteria,371NX@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
k59_1354981_2	1120953.AUBH01000007_gene1726	2.05e-26	100.0	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,1S90Z@1236|Gammaproteobacteria,468JG@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	COG2863 Cytochrome c553	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_1354981_3	393595.ABO_2540	1.21e-30	113.0	COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,1S9Z9@1236|Gammaproteobacteria,1XKPZ@135619|Oceanospirillales	135619|Oceanospirillales	C	cytochrome c5	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_298578_2	471853.Bcav_2151	6.19e-67	216.0	COG0287@1|root,COG0287@2|Bacteria,2GKB4@201174|Actinobacteria	201174|Actinobacteria	E	Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
k59_887881_1	933262.AXAM01000001_gene418	1.14e-52	174.0	COG0745@1|root,COG0745@2|Bacteria,1QW1Y@1224|Proteobacteria,43BS5@68525|delta/epsilon subdivisions,2X72Y@28221|Deltaproteobacteria,2MPJE@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,zinc_ribbon_4
k59_122249_1	944481.JAFP01000001_gene700	4.97e-61	200.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2WMQ8@28221|Deltaproteobacteria,2M6VN@213113|Desulfurellales	28221|Deltaproteobacteria	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
k59_122249_2	1437824.BN940_00686	4.03e-16	81.3	COG0169@1|root,COG0169@2|Bacteria,1Q95E@1224|Proteobacteria,2VJX5@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	-	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,SKI,Shikimate_dh_N
k59_1413894_1	367299.JOEE01000003_gene2677	8.85e-94	301.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,4FEFA@85021|Intrasporangiaceae	201174|Actinobacteria	D	Cell division protein FtsK	ftsK	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_180983_1	880072.Desac_0635	1.15e-90	284.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42QFH@68525|delta/epsilon subdivisions,2WKWR@28221|Deltaproteobacteria,2MREA@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_6772_1	446471.Xcel_1898	1.76e-115	349.0	COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria,4F36H@85017|Promicromonosporaceae	201174|Actinobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_1589472_2	999541.bgla_1g33430	8.88e-49	166.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2VHNA@28216|Betaproteobacteria,1K09V@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_415587_1	105559.Nwat_2118	3.94e-49	172.0	COG2170@1|root,COG2170@2|Bacteria,1MXET@1224|Proteobacteria,1RPKZ@1236|Gammaproteobacteria,1WWXK@135613|Chromatiales	135613|Chromatiales	S	glutamate--cysteine ligase	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
k59_415587_2	765911.Thivi_1974	2.39e-43	148.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,1S23A@1236|Gammaproteobacteria,1WWYC@135613|Chromatiales	135613|Chromatiales	JM	PFAM Nucleotidyl transferase	-	-	2.7.7.99	ko:K00992	ko00520,ko01100,map00520,map01100	-	R11025	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
k59_474505_1	472759.Nhal_3151	3.36e-103	320.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WXFD@135613|Chromatiales	135613|Chromatiales	P	PFAM Cation	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_1237901_1	396588.Tgr7_0841	2.17e-77	244.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1WWW0@135613|Chromatiales	135613|Chromatiales	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
k59_474511_1	316067.Geob_2357	1.38e-41	147.0	COG0577@1|root,COG0577@2|Bacteria,1MX7X@1224|Proteobacteria,42NT4@68525|delta/epsilon subdivisions,2WJFM@28221|Deltaproteobacteria,43T76@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_709326_1	1380370.JIBA01000018_gene446	2.32e-21	87.4	COG4803@1|root,COG4803@2|Bacteria,2IIN1@201174|Actinobacteria,4FJ74@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane protein of uknown function UCP014873	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_709326_2	1386089.N865_07550	5.91e-11	61.6	COG0641@1|root,COG0641@2|Bacteria	2|Bacteria	C	radical SAM	aslB	GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:1901564	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SEC-C,SPASM
k59_946784_1	592015.HMPREF1705_01605	6.17e-18	85.9	COG0688@1|root,COG0688@2|Bacteria,3TB26@508458|Synergistetes	508458|Synergistetes	I	phosphatidylserine decarboxylase	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
k59_298606_1	590998.Celf_3740	4.58e-95	291.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2GJB6@201174|Actinobacteria,4F0Y1@85016|Cellulomonadaceae	201174|Actinobacteria	H	PFAM UBA THIF-type NAD FAD binding protein	moeZ	-	2.7.7.80,2.8.1.11	ko:K21029,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
k59_6808_1	645991.Sgly_3080	5.79e-36	136.0	COG0303@1|root,COG0303@2|Bacteria,1TQJ8@1239|Firmicutes,248WP@186801|Clostridia,2613I@186807|Peptococcaceae	186801|Clostridia	H	MoeA N-terminal region (domain I and II)	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_1765697_1	1286106.MPL1_00497	9.76e-67	205.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria,460IN@72273|Thiotrichales	72273|Thiotrichales	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
k59_240698_1	768671.ThimaDRAFT_1588	1.85e-20	89.7	COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria,1WVWS@135613|Chromatiales	135613|Chromatiales	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	apaH	-	3.6.1.41	ko:K01525	ko00230,map00230	-	R00125	RC00002	ko00000,ko00001,ko01000	-	-	-	Metallophos
k59_127908_1	631362.Thi970DRAFT_02462	1.56e-100	303.0	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,1S02U@1236|Gammaproteobacteria,1WX9F@135613|Chromatiales	135613|Chromatiales	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
k59_127908_2	983917.RGE_08790	1.58e-11	64.3	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2VIH5@28216|Betaproteobacteria,1KIT5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Displays ATPase and GTPase activities	yhbJ	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
k59_1480370_1	177437.HRM2_30200	1.04e-56	188.0	COG0392@1|root,COG0392@2|Bacteria,1R98C@1224|Proteobacteria,42U6V@68525|delta/epsilon subdivisions,2WKTZ@28221|Deltaproteobacteria,2MJCJ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
k59_1594412_1	1122603.ATVI01000008_gene2234	3.8e-31	114.0	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,1S40Q@1236|Gammaproteobacteria,1X5XX@135614|Xanthomonadales	135614|Xanthomonadales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_1594412_2	754477.Q7C_2134	1.42e-39	140.0	2BVTQ@1|root,2Z7J9@2|Bacteria,1P01Z@1224|Proteobacteria,1RNNB@1236|Gammaproteobacteria,4603Z@72273|Thiotrichales	72273|Thiotrichales	S	Protein of unknown function (DUF2797)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2797
k59_186628_1	269799.Gmet_2946	2.25e-16	78.6	COG0637@1|root,COG1514@1|root,COG0637@2|Bacteria,COG1514@2|Bacteria,1QUMB@1224|Proteobacteria,43BM1@68525|delta/epsilon subdivisions,2X6Z7@28221|Deltaproteobacteria,43URF@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	HAD-superfamily hydrolase subfamily IA, variant 3	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	Hydrolase
k59_1124059_1	926569.ANT_19930	4.84e-41	149.0	COG1413@1|root,COG1413@2|Bacteria,2G6MW@200795|Chloroflexi	200795|Chloroflexi	C	PBS lyase HEAT domain protein repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
k59_1834644_1	479434.Sthe_2092	5.67e-32	130.0	COG1074@1|root,COG1074@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase activity	-	-	3.1.11.5,3.1.12.1,3.6.4.12	ko:K01144,ko:K07464,ko:K16898	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_186631_1	396588.Tgr7_2655	1.24e-65	215.0	COG1295@1|root,COG1959@1|root,COG1295@2|Bacteria,COG1959@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1WWKW@135613|Chromatiales	135613|Chromatiales	K	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Rrf2,Virul_fac_BrkB
k59_832046_1	266265.Bxe_C0490	3.2e-50	172.0	COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2VWYN@28216|Betaproteobacteria,1K8UX@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	Transposase_20
k59_1770605_1	381666.H16_B0948	7.38e-49	176.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2VIEA@28216|Betaproteobacteria,1KFF9@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	nirB	-	1.18.1.1,1.7.1.15	ko:K00362,ko:K05297	ko00071,ko00910,ko01120,map00071,map00910,map01120	M00530	R00787,R02000	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
k59_1712163_1	522306.CAP2UW1_1752	3.61e-72	224.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_1419677_1	1121434.AULY01000009_gene2031	3.55e-35	138.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria,2M9FS@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Glycine radical	-	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
k59_17179_1	1049564.TevJSym_au00280	2.97e-14	67.4	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,1S8VH@1236|Gammaproteobacteria,1J6K6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_17179_2	545276.KB898724_gene1817	2.72e-10	62.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1535999_1	1304885.AUEY01000026_gene3551	3.42e-20	94.7	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MIZ@68525|delta/epsilon subdivisions,2WIUX@28221|Deltaproteobacteria,2MHR5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	CHASE5,HAMP,HATPase_c,HisKA,dCache_1,dCache_2
k59_1069800_1	266835.14022846	1.72e-68	217.0	COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,2TU08@28211|Alphaproteobacteria,43PT0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	xdhB	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_771703_1	1033802.SSPSH_000411	2.63e-48	172.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_895295_1	96561.Dole_0706	1.5e-191	541.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2MHTQ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_714923_1	1035308.AQYY01000001_gene2490	9.04e-72	240.0	COG1615@1|root,COG1615@2|Bacteria,1TQHM@1239|Firmicutes,248PM@186801|Clostridia,260EY@186807|Peptococcaceae	186801|Clostridia	S	PFAM Uncharacterised protein family UPF0182	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_1480408_1	396588.Tgr7_2197	1.66e-182	523.0	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,1RR1J@1236|Gammaproteobacteria,1WVZY@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,CbiA,GATase_3
k59_1360049_1	1229517.AMFD01000004_gene1044	4.1e-40	153.0	COG1164@1|root,COG1164@2|Bacteria,1TP4P@1239|Firmicutes,4HA7X@91061|Bacilli,1YBD9@1357|Lactococcus	91061|Bacilli	E	Oligopeptidase F	pepF	GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
k59_479733_1	1249627.D779_2151	4.96e-109	333.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1WWDT@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,Fer4_9,Pyr_redox_2
k59_1306450_1	765912.Thimo_1099	7.36e-102	308.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,1WWM3@135613|Chromatiales	135613|Chromatiales	S	PFAM Alpha beta hydrolase	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4
k59_538549_1	1385521.N803_06075	8.11e-97	286.0	COG1057@1|root,COG1057@2|Bacteria,2GMFZ@201174|Actinobacteria,4FF49@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_714930_1	335543.Sfum_1949	1.56e-06	55.1	COG5000@1|root,COG5000@2|Bacteria,1RHCV@1224|Proteobacteria,42TBY@68525|delta/epsilon subdivisions,2WP6T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9
k59_1594440_1	867845.KI911784_gene1605	4.99e-13	75.9	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	CARDB,DUF4091,FlgD_ig,Laminin_G_3,PKD,Peptidase_M43
k59_1360060_1	1313172.YM304_01570	8.53e-80	248.0	COG0402@1|root,COG0402@2|Bacteria,2ISY0@201174|Actinobacteria	201174|Actinobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_954290_1	105559.Nwat_0980	1.01e-55	193.0	COG0508@1|root,COG1249@1|root,COG0508@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1WWGK@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding,Pyr_redox_2,Pyr_redox_dim
k59_367085_1	765914.ThisiDRAFT_0970	3.7e-20	90.1	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXE7@135613|Chromatiales	135613|Chromatiales	GM	NAD-dependent epimerase dehydratase	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
k59_367085_2	713586.KB900536_gene2507	7.76e-87	268.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,1WWKR@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases	cca	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
k59_1834682_1	396014.BF93_08455	5.08e-79	253.0	COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria,4FCJM@85020|Dermabacteraceae	201174|Actinobacteria	M	Penicillin binding protein transpeptidase domain	pbpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
k59_1594447_1	1276920.ADIAG_01914	4.1e-111	341.0	COG2213@1|root,COG4668@1|root,COG2213@2|Bacteria,COG4668@2|Bacteria,2GMYR@201174|Actinobacteria,1WAKG@1268|Micrococcaceae	201174|Actinobacteria	G	Phosphotransferase system, EIIC	mtlA	-	2.7.1.197	ko:K02798,ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	M00274	R02704	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5	-	-	PTS_EIIA_2,PTS_EIIC,PTS_IIB
k59_73568_1	1121405.dsmv_3030	5.13e-102	303.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,42PQH@68525|delta/epsilon subdivisions,2WM5W@28221|Deltaproteobacteria,2MN4X@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
k59_1712194_1	314230.DSM3645_14325	5.7e-23	102.0	COG0841@1|root,COG0841@2|Bacteria,2IY0S@203682|Planctomycetes	203682|Planctomycetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1006663_1	366649.XFF4834R_chr06540	4.93e-59	202.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RSG9@1236|Gammaproteobacteria,1X3F8@135614|Xanthomonadales	135614|Xanthomonadales	E	aminopeptidase	pepN	-	-	-	-	-	-	-	-	-	-	-	Leuk-A4-hydro_C,Peptidase_M1
k59_127977_2	1146883.BLASA_0999	5.34e-36	135.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PA,PKD
k59_1712199_2	1265310.CCBD010000002_gene4874	0.000272	44.7	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,2341C@1762|Mycobacteriaceae	2|Bacteria	T	PFAM Protein phosphatase 2C	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
k59_17230_1	1158146.KB907126_gene1617	2.66e-32	130.0	COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,1S3FX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_127979_1	1249627.D779_2750	4.87e-91	293.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWAU@135613|Chromatiales	135613|Chromatiales	U	Hydrophobe Amphiphile Efflux-1 (HAE1)	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_367106_1	1121468.AUBR01000032_gene1171	5.92e-35	130.0	COG0602@1|root,COG0602@2|Bacteria,1TQ58@1239|Firmicutes,2499R@186801|Clostridia,42H0P@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_12,Fer4_14,Radical_SAM
k59_1006672_1	502025.Hoch_1221	3.89e-65	215.0	COG3385@1|root,COG3385@2|Bacteria,1NBHF@1224|Proteobacteria,43BBP@68525|delta/epsilon subdivisions,2WRX0@28221|Deltaproteobacteria,2Z20S@29|Myxococcales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_895347_1	880072.Desac_0499	1.82e-154	444.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,42NP0@68525|delta/epsilon subdivisions,2WVG4@28221|Deltaproteobacteria,2MRQ6@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_303628_1	1347342.BN863_33810	5.41e-10	64.3	COG0457@1|root,COG0457@2|Bacteria,4NF5V@976|Bacteroidetes,1HYKU@117743|Flavobacteriia	976|Bacteroidetes	T	tetratricopeptide repeat	batE	-	-	-	-	-	-	-	-	-	-	-	SH3_3,SH3_4,TPR_1,TPR_11,TPR_16,TPR_2
k59_17244_1	391008.Smal_3327	9.98e-17	80.9	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1X3TV@135614|Xanthomonadales	135614|Xanthomonadales	M	gamma-glutamyltransferase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_17244_2	375286.mma_0612	5.41e-15	73.9	2BVW3@1|root,2Z7TB@2|Bacteria,1MY60@1224|Proteobacteria,2VJKN@28216|Betaproteobacteria,4740J@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	5'-nucleotidase	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5-nucleotidase
k59_1124107_1	765420.OSCT_2638	4.93e-42	148.0	COG2120@1|root,COG2120@2|Bacteria,2G6W3@200795|Chloroflexi,375I3@32061|Chloroflexia	32061|Chloroflexia	S	PFAM LmbE family protein	-	-	3.5.1.115	ko:K18455	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
k59_17245_1	880072.Desac_1210	2.37e-105	320.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WKS0@28221|Deltaproteobacteria,2MQ9R@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1594927_1	1173028.ANKO01000136_gene2476	1.61e-31	119.0	COG3271@1|root,COG3271@2|Bacteria,1G37M@1117|Cyanobacteria,1H999@1150|Oscillatoriales	1117|Cyanobacteria	S	Phytochelatin synthase	-	-	-	-	-	-	-	-	-	-	-	-	Phytochelatin
k59_1070530_1	288000.BBta_2026	9.24e-72	232.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3JRKR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_954941_1	1162668.LFE_1389	1.64e-61	206.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_832619_1	580327.Tthe_1908	9.5e-77	238.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,42EYC@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_251810_2	1266908.AQPB01000037_gene447	2.28e-38	134.0	2AEMZ@1|root,314HW@2|Bacteria,1RHE3@1224|Proteobacteria,1S7P7@1236|Gammaproteobacteria,1WYF1@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1185271_1	1304275.C41B8_05733	2.01e-12	65.5	COG1863@1|root,COG1863@2|Bacteria,1MZYJ@1224|Proteobacteria,1S7Z3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Cation antiporter	mnhE	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
k59_539026_1	1158762.KB898040_gene1370	2.35e-73	228.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1WW3F@135613|Chromatiales	135613|Chromatiales	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
k59_539026_2	1049564.TevJSym_au00590	2.01e-78	240.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1J5GV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0030091,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_1307103_1	1121405.dsmv_3248	6.06e-43	149.0	28PNF@1|root,2ZCB7@2|Bacteria,1RA6N@1224|Proteobacteria,42RBI@68525|delta/epsilon subdivisions,2WN4P@28221|Deltaproteobacteria,2MJHU@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1712630_1	1198232.CYCME_0725	3.78e-52	172.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,460JE@72273|Thiotrichales	72273|Thiotrichales	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_1835346_2	1265313.HRUBRA_01486	5.84e-36	134.0	COG3660@1|root,COG3660@2|Bacteria,1R70U@1224|Proteobacteria,1SKFB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Mitochondrial fission ELM1	-	-	-	-	-	-	-	-	-	-	-	-	Mito_fiss_Elm1
k59_1594938_1	439235.Dalk_1460	3.52e-128	388.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MJ5T@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1360543_1	1121918.ARWE01000001_gene3325	1.89e-132	409.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Hydrophobe amphiphile Efflux-1 (HAE1) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran,OEP
k59_1246096_1	367299.JOEE01000008_gene513	3.14e-27	110.0	COG1403@1|root,COG1403@2|Bacteria,2I9AH@201174|Actinobacteria,4FG65@85021|Intrasporangiaceae	201174|Actinobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_1246096_2	367299.JOEE01000009_gene302	1.59e-16	77.8	COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria,4FEZ8@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3708c	Semialdhyde_dh,Semialdhyde_dhC
k59_1360544_1	329726.AM1_2079	3.62e-40	144.0	COG1173@1|root,COG1173@2|Bacteria,1G0CD@1117|Cyanobacteria	1117|Cyanobacteria	P	'ABC-type dipeptide oligopeptide nickel transport	appC	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
k59_18177_1	680198.SCAB_64321	1.12e-61	194.0	COG1225@1|root,COG1225@2|Bacteria,2GKME@201174|Actinobacteria	201174|Actinobacteria	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	ahpE	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
k59_18177_2	2055.JNXA01000009_gene1373	3.21e-08	53.1	COG1942@1|root,COG1942@2|Bacteria,2IR76@201174|Actinobacteria,4GEM5@85026|Gordoniaceae	201174|Actinobacteria	S	Tautomerase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Tautomerase
k59_128487_1	1094184.KWO_0108925	7.4e-22	92.4	COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,1S5MD@1236|Gammaproteobacteria,1X7R8@135614|Xanthomonadales	135614|Xanthomonadales	C	Prokaryotic cytochrome b561	-	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
k59_128487_2	748247.AZKH_3657	4.53e-23	99.0	28JQB@1|root,2Z9G8@2|Bacteria,1QCH9@1224|Proteobacteria,2VJJF@28216|Betaproteobacteria,2KW13@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1536517_1	1693.BMIN_0198	4.05e-17	85.1	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria,4D075@85004|Bifidobacteriales	201174|Actinobacteria	G	Alpha amylase, catalytic domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_1536517_3	1150398.JIBJ01000002_gene1149	4.67e-53	175.0	COG1277@1|root,COG1277@2|Bacteria,2GP6D@201174|Actinobacteria,1WB69@1268|Micrococcaceae	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
k59_772134_1	266264.Rmet_1541	5.5e-110	336.0	COG0223@1|root,COG1024@1|root,COG0223@2|Bacteria,COG1024@2|Bacteria,1MWYJ@1224|Proteobacteria,2VK38@28216|Betaproteobacteria,1KBJJ@119060|Burkholderiaceae	28216|Betaproteobacteria	IJ	Formyl transferase	hoxX	-	-	ko:K19640	-	-	-	-	ko00000,ko02022	-	-	-	ECH_1,Formyl_trans_C,Formyl_trans_N
k59_367747_1	1298858.AUEL01000013_gene4974	6.5e-68	219.0	COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,2TU6K@28211|Alphaproteobacteria,43KS6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	FAD dependent oxidoreductase	-	-	-	ko:K15736	-	-	-	-	ko00000,ko01000	-	-	-	DAO
k59_715478_1	547144.HydHO_1443	1.14e-31	121.0	COG1692@1|root,COG1692@2|Bacteria,2G3Y9@200783|Aquificae	200783|Aquificae	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
k59_304093_1	937777.Deipe_2101	6.24e-41	140.0	2BYEQ@1|root,32SXE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1070565_1	1300345.LF41_1682	2.02e-31	128.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1X4K0@135614|Xanthomonadales	135614|Xanthomonadales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_378431_1	570952.ATVH01000015_gene1243	3.45e-62	198.0	COG2181@1|root,COG2181@2|Bacteria,1MXGZ@1224|Proteobacteria,2TTDB@28211|Alphaproteobacteria,2JR8E@204441|Rhodospirillales	204441|Rhodospirillales	C	nitrate reductase, gamma subunit	-	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
k59_488517_1	1713.JOFV01000011_gene2488	5.69e-118	345.0	COG0447@1|root,COG0447@2|Bacteria,2GK5G@201174|Actinobacteria,4F24A@85016|Cellulomonadaceae	201174|Actinobacteria	H	Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily	menB	-	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_488517_2	1454010.JEOE01000059_gene924	4.29e-43	150.0	COG4948@1|root,COG4948@2|Bacteria,2GJJR@201174|Actinobacteria,4F0IF@85016|Cellulomonadaceae	201174|Actinobacteria	M	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	GO:0008150,GO:0040007	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0553	MR_MLE_C
k59_1083011_1	1415779.JOMH01000001_gene1026	8.76e-95	307.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RNWM@1236|Gammaproteobacteria,1X9Y5@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein export membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	MMPL
k59_1603177_1	1266925.JHVX01000002_gene709	3.35e-37	128.0	COG3293@1|root,COG3293@2|Bacteria,1N8GF@1224|Proteobacteria,2WBR1@28216|Betaproteobacteria,373MQ@32003|Nitrosomonadales	28216|Betaproteobacteria	L	InterPro IPR002559	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2
k59_1603177_2	358220.C380_11710	2.31e-20	84.7	COG3293@1|root,COG3293@2|Bacteria,1N1CW@1224|Proteobacteria,2VUUH@28216|Betaproteobacteria,4AJPD@80864|Comamonadaceae	28216|Betaproteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DUF4096
k59_1318810_1	391615.ABSJ01000014_gene1624	1.14e-102	311.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,1J5GM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_1779569_1	314278.NB231_02063	1.62e-100	309.0	COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,1RMHA@1236|Gammaproteobacteria,1WW1K@135613|Chromatiales	135613|Chromatiales	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
k59_1544986_1	1210045.ALNP01000002_gene3975	4.43e-12	71.6	COG3899@1|root,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,DZR,Guanylate_cyc,Trans_reg_C
k59_1603185_1	367299.JOEE01000010_gene3340	1.71e-96	299.0	COG3428@1|root,COG3428@2|Bacteria,2GJCD@201174|Actinobacteria,4FFQR@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
k59_136926_1	1453496.AT03_10245	7.06e-18	83.6	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RNPX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015399,GO:0015405,GO:0015417,GO:0015595,GO:0015606,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0015848,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0097159,GO:0097367,GO:0098533,GO:0098655,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902047,GO:1902494,GO:1902495,GO:1903711,GO:1904949,GO:1990351	3.6.3.31	ko:K02052,ko:K11072,ko:K11076	ko02010,ko02024,map02010,map02024	M00193,M00299,M00300	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11,3.A.1.11.1,3.A.1.11.2	-	iB21_1397.B21_01132,iECBD_1354.ECBD_2473,iECB_1328.ECB_01124,iECD_1391.ECD_01124,iECO111_1330.ECO111_1474,iECO26_1355.ECO26_1643,iEcHS_1320.EcHS_A1246,iEcolC_1368.EcolC_2477,iSBO_1134.SBO_1915,iSSON_1240.SSON_1144,iSbBS512_1146.SbBS512_E1304,iUMNK88_1353.UMNK88_1456	ABC_tran,TOBE_2
k59_85814_1	391038.Bphy_5504	1.17e-26	109.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1K0FI@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Efflux pump membrane transporter	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_85814_2	391038.Bphy_5505	1.14e-18	86.7	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,1K1DV@119060|Burkholderiaceae	28216|Betaproteobacteria	MU	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
k59_312579_2	1123278.KB893499_gene329	3.45e-27	102.0	2C4KB@1|root,32YM4@2|Bacteria,4NUZU@976|Bacteroidetes,47RBT@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_195534_1	96561.Dole_1719	1.16e-80	266.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,2MHU0@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_1083029_1	1394178.AWOO02000044_gene4477	5.64e-110	352.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1014048_1	83406.HDN1F_02570	3.99e-112	339.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1J8FQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_907676_1	879212.DespoDRAFT_00919	1.39e-67	221.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,42NEZ@68525|delta/epsilon subdivisions,2WJ5R@28221|Deltaproteobacteria,2MHMS@213118|Desulfobacterales	28221|Deltaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_1779581_1	435830.HMPREF0045_00680	2.29e-65	222.0	COG1640@1|root,COG1640@2|Bacteria,2GM5Z@201174|Actinobacteria,4D33D@85005|Actinomycetales	201174|Actinobacteria	G	4-alpha-glucanotransferase	malQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_547081_1	1049564.TevJSym_bb00300	1.16e-110	325.0	COG3437@1|root,COG3437@2|Bacteria,1QUN9@1224|Proteobacteria,1S0ZZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KT	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	PAS,PAS_9,Response_reg
k59_264208_1	1198232.CYCME_1706	0.000413	45.4	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,46227@72273|Thiotrichales	72273|Thiotrichales	F	Ribonucleotide reductase, barrel domain	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC
k59_379383_2	439235.Dalk_0285	1.95e-19	85.9	COG0727@1|root,COG0727@2|Bacteria,1Q0JM@1224|Proteobacteria,42N6S@68525|delta/epsilon subdivisions,2WMTR@28221|Deltaproteobacteria,2MIXY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_1779586_1	1297569.MESS2_p130005	1.3e-112	337.0	COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,2U9U2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_907687_1	314278.NB231_08745	2.81e-44	146.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,1S617@1236|Gammaproteobacteria,1X1IW@135613|Chromatiales	135613|Chromatiales	O	FKBP-type peptidyl-prolyl cis-trans	-	-	-	-	-	-	-	-	-	-	-	-	FKBP_C
k59_1369111_1	644283.Micau_1915	2.12e-179	521.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4DACC@85008|Micromonosporales	201174|Actinobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	coxL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1014057_1	1118058.CAGY01000001_gene190	8.44e-16	78.6	2DN32@1|root,32V8W@2|Bacteria,2H7CK@201174|Actinobacteria,4D36H@85005|Actinomycetales	201174|Actinobacteria	S	Putative bacterial sensory transduction regulator	-	-	-	-	-	-	-	-	-	-	-	-	YbjN
k59_1847036_1	1167006.UWK_01948	1.63e-32	125.0	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,42KZP@68525|delta/epsilon subdivisions,2WKSV@28221|Deltaproteobacteria,2MHUQ@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,PAS
k59_907693_1	768671.ThimaDRAFT_3180	1.54e-41	146.0	2DBXS@1|root,2ZBR1@2|Bacteria,1RBUD@1224|Proteobacteria,1S1ZK@1236|Gammaproteobacteria,1X03Q@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1491775_1	257310.BB2987	2.18e-80	252.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VJME@28216|Betaproteobacteria,3T1P1@506|Alcaligenaceae	28216|Betaproteobacteria	G	TRAP-type C4-dicarboxylate transport system, large permease component	siaT_7	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1545016_1	1249627.D779_4207	3.39e-86	269.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1WWGN@135613|Chromatiales	135613|Chromatiales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_264231_1	243265.plu3972	3.32e-13	74.7	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases	cca	GO:0001680,GO:0003674,GO:0003824,GO:0004652,GO:0004810,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016437,GO:0016740,GO:0016772,GO:0016779,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042245,GO:0042780,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0070566,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990817	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
k59_723612_1	296591.Bpro_4885	4.41e-08	55.1	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2VHKJ@28216|Betaproteobacteria,4AAM2@80864|Comamonadaceae	28216|Betaproteobacteria	P	Sulfate transporter antisigma-factor antagonist STAS	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_723612_3	1042876.PPS_0798	7.96e-05	43.9	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,1RNMF@1236|Gammaproteobacteria,1YV9E@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1722)	ybgA	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
k59_1603211_1	211114.JOEF01000001_gene7080	1.55e-195	555.0	COG1760@1|root,COG1760@2|Bacteria,2GJPA@201174|Actinobacteria,4DY5U@85010|Pseudonocardiales	201174|Actinobacteria	E	Serine dehydratase beta chain	sdaA	GO:0003674,GO:0003824,GO:0003941,GO:0016829,GO:0016840,GO:0016841	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha,SDH_beta
k59_1318867_2	1121405.dsmv_0234	3.16e-67	220.0	COG1055@1|root,COG1055@2|Bacteria,1N68M@1224|Proteobacteria,42PD9@68525|delta/epsilon subdivisions,2WKRV@28221|Deltaproteobacteria,2MMQP@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Putative Na+/H+ antiporter	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiport_3
k59_1491782_1	339671.Asuc_0039	1.56e-15	75.9	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1Y7XU@135625|Pasteurellales	135625|Pasteurellales	JKL	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_1491782_2	1168067.JAGP01000001_gene33	5.08e-18	77.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,1S5WR@1236|Gammaproteobacteria,460UP@72273|Thiotrichales	72273|Thiotrichales	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_1083067_1	397945.Aave_0778	0.000644	43.9	2E54A@1|root,32ZX9@2|Bacteria,1N8HJ@1224|Proteobacteria,2VVW9@28216|Betaproteobacteria,4AFMV@80864|Comamonadaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF1840)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1840
k59_136950_2	7227.FBpp0301765	1.68e-12	70.1	COG5083@1|root,KOG3668@2759|Eukaryota,38C2H@33154|Opisthokonta,3BB4C@33208|Metazoa,3CT3I@33213|Bilateria,41U1Q@6656|Arthropoda,3SJ3X@50557|Insecta,44X8J@7147|Diptera	33208|Metazoa	IT	It is involved in the biological process described with transport	PITPNB	GO:0000003,GO:0000062,GO:0000139,GO:0000166,GO:0000212,GO:0000226,GO:0000280,GO:0000902,GO:0000904,GO:0000910,GO:0000912,GO:0000915,GO:0000916,GO:0001700,GO:0001701,GO:0003008,GO:0003674,GO:0005215,GO:0005319,GO:0005488,GO:0005504,GO:0005543,GO:0005548,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005737,GO:0005739,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0006629,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0006890,GO:0006996,GO:0006997,GO:0007010,GO:0007017,GO:0007049,GO:0007051,GO:0007110,GO:0007111,GO:0007112,GO:0007140,GO:0007154,GO:0007165,GO:0007166,GO:0007275,GO:0007276,GO:0007283,GO:0007399,GO:0007409,GO:0007600,GO:0007601,GO:0008150,GO:0008152,GO:0008289,GO:0008525,GO:0008526,GO:0009653,GO:0009790,GO:0009792,GO:0009987,GO:0010033,GO:0010876,GO:0012505,GO:0015711,GO:0015748,GO:0015914,GO:0016006,GO:0016020,GO:0016021,GO:0016043,GO:0016192,GO:0017076,GO:0019221,GO:0019953,GO:0022008,GO:0022402,GO:0022412,GO:0022414,GO:0022607,GO:0023052,GO:0030029,GO:0030030,GO:0030036,GO:0030154,GO:0030182,GO:0030554,GO:0030865,GO:0030866,GO:0031032,GO:0031090,GO:0031175,GO:0031210,GO:0031224,GO:0031406,GO:0031566,GO:0031965,GO:0031967,GO:0031975,GO:0031984,GO:0032153,GO:0032154,GO:0032155,GO:0032501,GO:0032502,GO:0032504,GO:0032506,GO:0032553,GO:0032555,GO:0032559,GO:0032989,GO:0032990,GO:0033036,GO:0033206,GO:0033218,GO:0033293,GO:0034097,GO:0035091,GO:0035722,GO:0036041,GO:0036094,GO:0036212,GO:0036213,GO:0042175,GO:0042221,GO:0043009,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043209,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043954,GO:0044085,GO:0044238,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044431,GO:0044432,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044703,GO:0044837,GO:0048037,GO:0048137,GO:0048193,GO:0048232,GO:0048285,GO:0048468,GO:0048609,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0050662,GO:0050789,GO:0050794,GO:0050877,GO:0050896,GO:0050953,GO:0050997,GO:0051179,GO:0051234,GO:0051301,GO:0051321,GO:0051704,GO:0051716,GO:0061564,GO:0061640,GO:0061982,GO:0061983,GO:0065007,GO:0070405,GO:0070540,GO:0070671,GO:0070732,GO:0070887,GO:0071310,GO:0071345,GO:0071349,GO:0071702,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0098588,GO:0098590,GO:0098791,GO:0098827,GO:0120036,GO:0120039,GO:0140013,GO:1901265,GO:1901363,GO:1901567,GO:1901611,GO:1901681,GO:1903046	-	-	-	-	-	-	-	-	-	-	IP_trans
k59_312605_1	1380354.JIAN01000006_gene731	6.38e-99	291.0	COG4977@1|root,COG4977@2|Bacteria,2I2KX@201174|Actinobacteria,4F28S@85016|Cellulomonadaceae	201174|Actinobacteria	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
k59_1721065_1	589873.EP13_10895	1.12e-16	80.1	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464X3@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran,DUF805
k59_1721065_2	1125863.JAFN01000001_gene913	1.93e-08	58.9	COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,42NTH@68525|delta/epsilon subdivisions,2WJ8N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1193685_1	395963.Bind_1369	6.64e-45	151.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,2TV09@28211|Alphaproteobacteria,3NAIJ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_1193685_2	1122152.AUEI01000006_gene57	3.15e-46	152.0	COG0096@1|root,COG0096@2|Bacteria,1V3KK@1239|Firmicutes,4HH32@91061|Bacilli,3F64E@33958|Lactobacillaceae	91061|Bacilli	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
k59_1193685_3	397290.C810_00308	2.36e-58	185.0	COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,247X0@186801|Clostridia,27IA8@186928|unclassified Lachnospiraceae	186801|Clostridia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_547106_1	1304865.JAGF01000001_gene1528	2.68e-85	265.0	COG5002@1|root,COG5002@2|Bacteria,2I3U8@201174|Actinobacteria	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_547106_2	1304865.JAGF01000001_gene1527	7.01e-127	365.0	COG0745@1|root,COG0745@2|Bacteria,2GMVN@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_966634_1	1121405.dsmv_1453	3.82e-29	107.0	2E6FN@1|root,3312Z@2|Bacteria,1N6QM@1224|Proteobacteria,42V22@68525|delta/epsilon subdivisions,2WRF9@28221|Deltaproteobacteria,2MM34@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1603222_2	1278309.KB907099_gene2835	1.21e-32	125.0	COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,1RQHX@1236|Gammaproteobacteria,1XHP4@135619|Oceanospirillales	135619|Oceanospirillales	S	Rossmann fold nucleotide-binding protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DUF3412,DUF4478,Lysine_decarbox
k59_665211_2	1232437.KL661954_gene2353	1.41e-52	170.0	COG0437@1|root,COG0437@2|Bacteria,1NF8S@1224|Proteobacteria,42WBD@68525|delta/epsilon subdivisions,2WRT3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
k59_1257162_1	289377.HL41_04940	1.98e-116	352.0	COG0111@1|root,COG0111@2|Bacteria,2GH7H@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_195575_1	526222.Desal_0072	4.78e-06	48.5	COG2191@1|root,COG2191@2|Bacteria,1RFFR@1224|Proteobacteria,42T0H@68525|delta/epsilon subdivisions,2WNH3@28221|Deltaproteobacteria,2MBFF@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Formylmethanofuran dehydrogenase, subunit E region	-	-	1.2.7.12	ko:K11261	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	FmdE,zf-dskA_traR
k59_195575_2	1265505.ATUG01000001_gene3573	2.57e-96	300.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2MIU8@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_429819_1	930169.B5T_02477	1.41e-90	286.0	COG4666@1|root,COG4666@2|Bacteria,1R58Z@1224|Proteobacteria,1SN2T@1236|Gammaproteobacteria,1XN7E@135619|Oceanospirillales	135619|Oceanospirillales	S	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_907732_1	1535422.ND16A_1247	2.77e-139	428.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1491809_1	1267005.KB911258_gene518	1.78e-67	222.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3N6FI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	lcfA	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_1083096_1	1435356.Y013_06170	2.45e-63	206.0	COG0327@1|root,COG0327@2|Bacteria,2GKHZ@201174|Actinobacteria,4FU38@85025|Nocardiaceae	201174|Actinobacteria	S	Belongs to the GTP cyclohydrolase I type 2 NIF3 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	NIF3
k59_312629_1	323261.Noc_2120	5.71e-88	283.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales	135613|Chromatiales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_1318905_1	481448.Minf_0222	1.81e-75	243.0	COG2262@1|root,COG2262@2|Bacteria,46SP4@74201|Verrucomicrobia,37FVB@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_1545046_2	765911.Thivi_0933	2.34e-25	102.0	COG2913@1|root,COG2913@2|Bacteria,1N6YW@1224|Proteobacteria,1SCTT@1236|Gammaproteobacteria,1WZIB@135613|Chromatiales	135613|Chromatiales	J	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamE	-	-	ko:K06186	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	SmpA_OmlA
k59_1721087_1	1121946.AUAX01000002_gene140	3.71e-42	152.0	COG5479@1|root,COG5479@2|Bacteria,2GS3Z@201174|Actinobacteria	201174|Actinobacteria	M	peptidoglycan receptor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_85898_2	497321.C664_02180	1.2e-40	139.0	COG0680@1|root,COG0680@2|Bacteria,1MZE1@1224|Proteobacteria,2VTPX@28216|Betaproteobacteria,2KWJ7@206389|Rhodocyclales	206389|Rhodocyclales	C	maturation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_312630_2	1384054.N790_00810	9.62e-40	147.0	COG0845@1|root,COG0845@2|Bacteria,1MX0G@1224|Proteobacteria,1RN0S@1236|Gammaproteobacteria,1X433@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_196294_1	879212.DespoDRAFT_02368	2.54e-98	303.0	COG5659@1|root,COG5659@2|Bacteria,1MXSA@1224|Proteobacteria,433H7@68525|delta/epsilon subdivisions,2WXZP@28221|Deltaproteobacteria,2MP9M@213118|Desulfobacterales	1224|Proteobacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_908878_1	572477.Alvin_2519	1.95e-100	305.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1WWPA@135613|Chromatiales	135613|Chromatiales	S	modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_908884_1	1500304.JQKY01000004_gene1338	1.52e-29	112.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,2U7B0@28211|Alphaproteobacteria,4BAE2@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	phosphotransferase system	ptsN	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044424,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
k59_1084078_1	1322246.BN4_12596	1.01e-52	186.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2M7WP@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_137737_1	880073.Calab_1785	8.7e-47	169.0	COG0709@1|root,COG1104@1|root,COG0709@2|Bacteria,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	selD	-	2.7.9.3,2.8.1.7	ko:K01008,ko:K04487	ko00450,ko00730,ko01100,ko04122,map00450,map00730,map01100,map04122	-	R03595,R07460,R11528,R11529	RC00002,RC01789,RC02313,RC02878	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	AIRS,AIRS_C,Aminotran_5
k59_547916_1	1121405.dsmv_1598	5.08e-49	171.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WJVC@28221|Deltaproteobacteria,2MINJ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
k59_606616_1	685727.REQ_32290	9.62e-21	84.3	COG2329@1|root,COG2329@2|Bacteria,2IQWX@201174|Actinobacteria,4G2YM@85025|Nocardiaceae	201174|Actinobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
k59_606616_2	1349820.M707_17925	1.62e-40	142.0	COG1108@1|root,COG1108@2|Bacteria,2GJ7H@201174|Actinobacteria,1W7XM@1268|Micrococcaceae	201174|Actinobacteria	P	ABC 3 transport family	mntB	-	-	ko:K09819,ko:K11602,ko:K19975,ko:K19976	ko02010,ko02020,map02010,map02020	M00243,M00316,M00792	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.1,3.A.1.15.15	-	-	ABC-3
k59_340937_1	1206731.BAGB01000173_gene127	9.75e-30	117.0	COG0044@1|root,COG0044@2|Bacteria,2GKEC@201174|Actinobacteria,4FWD5@85025|Nocardiaceae	201174|Actinobacteria	F	Amidohydrolase family	-	-	3.5.2.2,3.5.2.3,3.5.2.5	ko:K01464,ko:K01465,ko:K01466	ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120	M00046,M00051,M00546	R01993,R02269,R02425,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
k59_340937_2	1121123.AUAO01000001_gene1552	1.25e-33	121.0	COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2U6ZN@28211|Alphaproteobacteria,2KGDK@204458|Caulobacterales	204458|Caulobacterales	O	Redoxin domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
k59_1456879_1	237368.SCABRO_03842	2.14e-45	163.0	COG1538@1|root,COG1538@2|Bacteria,2IX1X@203682|Planctomycetes	203682|Planctomycetes	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1803608_1	1123228.AUIH01000005_gene675	1.09e-33	130.0	COG1307@1|root,COG1307@2|Bacteria,1R5M9@1224|Proteobacteria,1RZYN@1236|Gammaproteobacteria,1XNWK@135619|Oceanospirillales	135619|Oceanospirillales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DegV
k59_1803608_2	550540.Fbal_1411	2.57e-11	63.2	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	COG0330 Membrane protease subunits stomatin prohibitin homologs	qmcA	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_1396533_1	187272.Mlg_0945	7.79e-107	317.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,1WX2E@135613|Chromatiales	135613|Chromatiales	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K00795,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_633294_1	765910.MARPU_02240	7.57e-80	256.0	COG0471@1|root,COG0569@1|root,COG0471@2|Bacteria,COG0569@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1WXUN@135613|Chromatiales	135613|Chromatiales	P	TrkA-C domain	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_1041747_2	1236902.ANAS01000020_gene1599	5.77e-37	137.0	COG1524@1|root,COG1524@2|Bacteria,2GP5S@201174|Actinobacteria,4EIHE@85012|Streptosporangiales	201174|Actinobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
k59_692793_2	314287.GB2207_08931	1.94e-16	78.6	COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,1SYEA@1236|Gammaproteobacteria,1J6I1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
k59_1803630_1	768671.ThimaDRAFT_4020	4.88e-67	207.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,1WY9Z@135613|Chromatiales	135613|Chromatiales	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	-	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
k59_1396548_1	796942.HMPREF9623_01830	1.21e-68	218.0	COG0535@1|root,COG0535@2|Bacteria,1TSAT@1239|Firmicutes,24A6W@186801|Clostridia	186801|Clostridia	S	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
k59_340964_1	765952.PUV_02090	2.59e-11	67.4	COG1075@1|root,COG1075@2|Bacteria,2JGD8@204428|Chlamydiae	204428|Chlamydiae	S	Lipase (class 2)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_693937_1	396588.Tgr7_3306	2.48e-44	151.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1WW4K@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_693937_2	187272.Mlg_2871	1.64e-19	88.6	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1WVYR@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_1458171_1	981369.JQMJ01000004_gene1886	5.11e-145	449.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2GN09@201174|Actinobacteria,2NEJ8@228398|Streptacidiphilus	201174|Actinobacteria	E	GXGXG motif	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1157714_2	1120949.KB903324_gene3258	3.07e-06	49.7	COG1295@1|root,COG1295@2|Bacteria,2IH35@201174|Actinobacteria	201174|Actinobacteria	S	ribonuclease BN	-	-	-	-	-	-	-	-	-	-	-	-	Virul_fac_BrkB
k59_753278_1	1121405.dsmv_2802	3.22e-102	303.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2WJ4U@28221|Deltaproteobacteria,2MJ7T@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
k59_870625_1	765911.Thivi_0952	3.31e-36	137.0	COG3278@1|root,COG3278@2|Bacteria,1P8T0@1224|Proteobacteria,1T4ST@1236|Gammaproteobacteria,1WW05@135613|Chromatiales	135613|Chromatiales	O	Belongs to the heme-copper respiratory oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_693967_1	522306.CAP2UW1_3784	1.25e-41	145.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	6.5.1.3	ko:K14680	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_106,Glyco_hydro_2_N,Metallophos,Metallophos_2,RNA_lig_T4_1
k59_1458202_2	1123401.JHYQ01000015_gene1348	1.18e-48	170.0	COG1073@1|root,COG1225@1|root,COG1073@2|Bacteria,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,1RQ7F@1236|Gammaproteobacteria,462CZ@72273|Thiotrichales	72273|Thiotrichales	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_224417_1	1148.1001341	2.7e-33	131.0	COG0598@1|root,COG0598@2|Bacteria,1G1AG@1117|Cyanobacteria,1H69I@1142|Synechocystis	1117|Cyanobacteria	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_1804624_1	589865.DaAHT2_1884	2.74e-38	142.0	COG3481@1|root,COG3481@2|Bacteria,1NH0C@1224|Proteobacteria,42Q7X@68525|delta/epsilon subdivisions,2WJW2@28221|Deltaproteobacteria,2MICY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	nucleic acid binding OB-fold tRNA helicase-type	yhaM	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
k59_1291440_1	748247.AZKH_3548	4.74e-120	358.0	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,2VHSF@28216|Betaproteobacteria,2KVT2@206389|Rhodocyclales	206389|Rhodocyclales	C	Cytochrome D1 heme domain	nirS	-	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_166354_1	438753.AZC_0188	1.9e-50	180.0	COG3243@1|root,COG3243@2|Bacteria,1MUNE@1224|Proteobacteria,2TRK4@28211|Alphaproteobacteria,3EY8J@335928|Xanthobacteraceae	28211|Alphaproteobacteria	I	Protein of unknown function (DUF3141)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3141
k59_1222811_2	717785.HYPMC_0626	7.19e-128	374.0	COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,2TR1Y@28211|Alphaproteobacteria,3N6JC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	yejE	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944	-	ko:K13895	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1,OppC_N
k59_1397790_1	1463879.JOHP01000008_gene331	1.32e-14	72.0	2E6NT@1|root,32UXC@2|Bacteria,2I895@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1397790_2	1284679.HMPREF1626_08825	9.47e-54	178.0	COG0596@1|root,COG0596@2|Bacteria,2GNBX@201174|Actinobacteria,4D4CN@85005|Actinomycetales	201174|Actinobacteria	S	Alpha/beta hydrolase family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
k59_1804632_1	1120949.KB903336_gene9632	3.56e-99	305.0	COG1960@1|root,COG1960@2|Bacteria,2GJIB@201174|Actinobacteria,4DB5B@85008|Micromonosporales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase N terminal	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,AcylCoA_DH_N
k59_1291452_1	384765.SIAM614_27308	1.49e-64	206.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2TTP8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	bcpA	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
k59_1525614_1	1157708.KB907486_gene4514	1.16e-103	310.0	COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2VWYN@28216|Betaproteobacteria,4AFWS@80864|Comamonadaceae	28216|Betaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1043300_1	765910.MARPU_14695	8.6e-32	118.0	COG3103@1|root,COG4991@2|Bacteria,1MX7M@1224|Proteobacteria,1RS74@1236|Gammaproteobacteria,1WY3A@135613|Chromatiales	135613|Chromatiales	T	SH3 domain	-	-	-	ko:K07184	-	-	-	-	ko00000	-	-	-	SH3_3
k59_1043300_2	748247.AZKH_3236	2.78e-33	123.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2VIVG@28216|Betaproteobacteria,2KV71@206389|Rhodocyclales	206389|Rhodocyclales	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_870688_1	471853.Bcav_2567	4.14e-195	556.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria	201174|Actinobacteria	H	Folylpolyglutamate synthase	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2447c	Mur_ligase_C,Mur_ligase_M
k59_1693141_1	572477.Alvin_1309	1.42e-91	275.0	2A5PE@1|root,30UE9@2|Bacteria,1PX3T@1224|Proteobacteria,1TA9Y@1236|Gammaproteobacteria,1WZSR@135613|Chromatiales	135613|Chromatiales	M	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
k59_1693144_1	1380391.JIAS01000019_gene1199	0.000127	50.4	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,2JR1T@204441|Rhodospirillales	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_1,TPR_16,TPR_19,TPR_2,TPR_8
k59_694033_1	1049564.TevJSym_ad01120	7.02e-94	305.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1J5AR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	COG1643 HrpA-like helicases	hrpA	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_694035_1	593750.Metfor_2247	3.95e-22	96.3	COG2135@1|root,arCOG02783@2157|Archaea,2Y7FY@28890|Euryarchaeota	28890|Euryarchaeota	S	SOS response associated peptidase (SRAP)	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
k59_870713_1	153948.NAL212_1293	5.49e-70	222.0	COG3677@1|root,COG3677@2|Bacteria,1R3ZS@1224|Proteobacteria,2WFCR@28216|Betaproteobacteria	1224|Proteobacteria	L	Transposase zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_634363_1	1146883.BLASA_2767	1.04e-58	209.0	COG2197@1|root,COG3899@1|root,COG2197@2|Bacteria,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,GerE
k59_1525657_1	323261.Noc_2985	2.49e-31	117.0	2DKHM@1|root,309GY@2|Bacteria,1RFJ6@1224|Proteobacteria,1S4EG@1236|Gammaproteobacteria,1X1R5@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1525657_2	105559.Nwat_3039	1.69e-19	85.9	2AI7D@1|root,33HQ0@2|Bacteria,1P2AB@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1397857_1	1279015.KB908458_gene2577	1.59e-82	265.0	COG1770@1|root,COG1770@2|Bacteria,1MUED@1224|Proteobacteria,1RMSV@1236|Gammaproteobacteria,1Y458@135624|Aeromonadales	135624|Aeromonadales	E	Protease II	-	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_166428_1	1386089.N865_08985	2.94e-05	49.7	2B4EP@1|root,31X68@2|Bacteria,2GYH4@201174|Actinobacteria,4FI1Z@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_166428_2	446469.Sked_32100	4.09e-23	92.4	COG0634@1|root,COG0634@2|Bacteria,2GMDZ@201174|Actinobacteria	201174|Actinobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_1157815_1	717605.Theco_0427	1.4e-20	91.7	COG0129@1|root,COG0129@2|Bacteria,1U56J@1239|Firmicutes,4HD31@91061|Bacilli,26U7U@186822|Paenibacillaceae	91061|Bacilli	EG	Belongs to the IlvD Edd family	-	-	4.2.1.82	ko:K22396	ko00040,map00040	-	R02429	RC00543	ko00000,ko00001,ko01000	-	-	-	ILVD_EDD
k59_1750109_1	1288494.EBAPG3_18410	1.19e-55	195.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,37271@32003|Nitrosomonadales	28216|Betaproteobacteria	L	DNA topoisomerase, type IA, central	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	SWIB,Topoisom_bac,Toprim,Toprim_Crpt
k59_1693189_1	1265313.HRUBRA_01485	1.96e-84	258.0	2DG8R@1|root,2ZUYV@2|Bacteria,1R8VA@1224|Proteobacteria,1T0PJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
k59_1157829_1	439496.RBY4I_3863	3.56e-122	354.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TQKB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_1525686_2	572477.Alvin_2173	9.06e-35	133.0	COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,1WW3V@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA	rlmL	-	2.1.1.173,2.1.1.264	ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
k59_694071_1	1444711.CCJF01000005_gene481	1.19e-17	80.9	COG2859@1|root,COG2859@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF541)	-	-	-	ko:K09797	-	-	-	-	ko00000	-	-	-	SIMPL
k59_694071_2	1500893.JQNB01000001_gene3497	7.12e-67	214.0	COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,1RNBX@1236|Gammaproteobacteria,1X45S@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyl-CoA dehydrogenase	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1397880_1	1535422.ND16A_0370	4.14e-52	181.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,2Q5VE@267889|Colwelliaceae	1236|Gammaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	narB	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1397880_2	1049564.TevJSym_aa00500	3.52e-100	308.0	COG0437@1|root,COG3302@1|root,COG0437@2|Bacteria,COG3302@2|Bacteria,1MU1B@1224|Proteobacteria,1SYHX@1236|Gammaproteobacteria,1J52W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	DMSO reductase anchor subunit (DmsC)	-	-	-	ko:K07307	ko00920,map00920	-	R09501	RC02555	ko00000,ko00001,ko02000	5.A.3.3	-	-	DmsC,Fer4_11,Fer4_4
k59_1458316_1	590998.Celf_1527	1.52e-217	616.0	COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria,4F0UQ@85016|Cellulomonadaceae	201174|Actinobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_1458316_2	935839.JAGJ01000007_gene3117	7.78e-141	405.0	COG0266@1|root,COG0266@2|Bacteria,2GKAM@201174|Actinobacteria,4F40T@85017|Promicromonosporaceae	201174|Actinobacteria	L	Formamidopyrimidine-DNA glycosylase H2TH domain	mutM1	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_1222918_1	1123377.AUIV01000009_gene2576	2.89e-42	147.0	COG0412@1|root,COG0412@2|Bacteria,1N607@1224|Proteobacteria,1S53B@1236|Gammaproteobacteria,1X65I@135614|Xanthomonadales	135614|Xanthomonadales	Q	Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_1750124_1	1249627.D779_0433	5.33e-31	120.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,1RMYQ@1236|Gammaproteobacteria,1WXFV@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
k59_166461_1	1121405.dsmv_2856	6.67e-85	267.0	COG3039@1|root,COG3039@2|Bacteria,1PKUP@1224|Proteobacteria,43ECD@68525|delta/epsilon subdivisions,2X0BQ@28221|Deltaproteobacteria,2MP4F@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_224530_1	1121405.dsmv_3828	7.44e-100	309.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42M6J@68525|delta/epsilon subdivisions,2WJZQ@28221|Deltaproteobacteria,2MJ1A@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM 3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.157,1.1.1.35,4.2.1.17	ko:K00074,ko:K15016	ko00360,ko00362,ko00650,ko00720,ko01100,ko01120,ko01200,map00360,map00362,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R01975,R01976,R03026,R05576,R06941	RC00029,RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N
k59_1632441_1	67352.JODS01000055_gene2239	3.72e-54	172.0	2C3KP@1|root,2Z802@2|Bacteria,2IFTZ@201174|Actinobacteria	201174|Actinobacteria	S	phage tail protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_166466_1	1121405.dsmv_2382	3.24e-27	117.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42MIV@68525|delta/epsilon subdivisions,2WJ5X@28221|Deltaproteobacteria,2MIC5@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_1804715_1	331869.BAL199_17763	2.13e-92	293.0	COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,2TTGI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Major facilitator Superfamily	aas	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase,MFS_1
k59_694079_2	1232683.ADIMK_0868	8.13e-103	313.0	COG0845@1|root,COG0845@2|Bacteria,1MX0G@1224|Proteobacteria,1RN0S@1236|Gammaproteobacteria,465RR@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_1397896_1	713586.KB900536_gene179	1.54e-46	165.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1WWWR@135613|Chromatiales	135613|Chromatiales	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_1397896_2	1123368.AUIS01000017_gene2572	4.28e-29	110.0	COG3086@1|root,COG3086@2|Bacteria	2|Bacteria	T	response to oxidative stress	rseC	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0016020,GO:0044464,GO:0050896,GO:0071944	-	ko:K03803	-	-	-	-	ko00000,ko03021	-	-	-	RseC_MucC
k59_1574314_1	95619.PM1_0229250	8.11e-53	183.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	clsA	GO:0003674,GO:0003824,GO:0008808,GO:0016740,GO:0016772,GO:0016780,GO:0030572	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
k59_1750131_2	367299.JOEE01000001_gene1986	3.31e-96	290.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4FEEA@85021|Intrasporangiaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_1750132_1	765912.Thimo_0109	7.73e-37	124.0	2C7TU@1|root,32RJT@2|Bacteria,1N2CD@1224|Proteobacteria,1S96C@1236|Gammaproteobacteria,1WYZ5@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1525709_2	1452718.JBOY01000068_gene1334	2.44e-60	194.0	COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,1RMYH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
k59_342208_1	765911.Thivi_1892	1.36e-147	443.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WW6D@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_753469_1	1408428.JNJP01000024_gene3736	1.68e-27	112.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2WIVT@28221|Deltaproteobacteria,2M80Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k59_753469_2	403833.Pmob_1237	3.3e-08	54.3	COG1974@1|root,COG1974@2|Bacteria,2GD29@200918|Thermotogae	200918|Thermotogae	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0032991,GO:0032993,GO:0043565,GO:0097159,GO:1901363	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_1043435_1	1121468.AUBR01000017_gene2400	5.22e-61	207.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,42F1S@68295|Thermoanaerobacterales	186801|Clostridia	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
k59_1693263_1	880072.Desac_2754	3.1e-47	165.0	COG0517@1|root,COG1993@1|root,COG2524@1|root,COG0517@2|Bacteria,COG1993@2|Bacteria,COG2524@2|Bacteria,1N0EM@1224|Proteobacteria,43BS4@68525|delta/epsilon subdivisions,2X72X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF190
k59_1632503_1	269799.Gmet_1210	1.05e-56	191.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N38@68525|delta/epsilon subdivisions,2WK56@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG,Cytochrom_C
k59_634459_1	998674.ATTE01000001_gene4354	3.81e-49	174.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,460GF@72273|Thiotrichales	72273|Thiotrichales	L	DNA photolyase	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_471722_2	1121405.dsmv_1447	7.91e-92	272.0	COG1014@1|root,COG1014@2|Bacteria,1R92Y@1224|Proteobacteria,42QJI@68525|delta/epsilon subdivisions,2WMFZ@28221|Deltaproteobacteria,2MJ4M@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate family	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
k59_823816_1	572477.Alvin_2781	3.2e-77	232.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,1WY0C@135613|Chromatiales	135613|Chromatiales	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_62031_1	868595.Desca_2512	7.66e-95	288.0	COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,247IZ@186801|Clostridia,260VU@186807|Peptococcaceae	186801|Clostridia	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_119581_1	323261.Noc_1687	4.05e-143	419.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1WWTW@135613|Chromatiales	135613|Chromatiales	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
k59_883902_1	314271.RB2654_16161	1.44e-18	81.6	COG5447@1|root,COG5447@2|Bacteria,1N1KU@1224|Proteobacteria,2UCBQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	GTP-binding protein Era	MA20_15690	-	-	-	-	-	-	-	-	-	-	-	DUF1491
k59_1234970_1	443143.GM18_4037	1.48e-42	160.0	COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,42T0V@68525|delta/epsilon subdivisions,2WPRT@28221|Deltaproteobacteria,43TPS@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
k59_942626_1	243233.MCA0383	1.59e-86	268.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1XDTZ@135618|Methylococcales	135618|Methylococcales	S	modulator of DNA gyrase	pmbA	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_765096_1	713587.THITH_06650	9.29e-117	383.0	COG2202@1|root,COG3221@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3221@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVV9@135613|Chromatiales	135613|Chromatiales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_3,PAS_9,Phosphonate-bd,Response_reg
k59_530492_1	1453501.JELR01000002_gene522	1.75e-41	148.0	COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,1RR3K@1236|Gammaproteobacteria,469GM@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Domain related to MnhB subunit of Na+/H+ antiporter	-	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB
k59_530492_2	398579.Spea_3282	5.54e-49	167.0	COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,1RR3K@1236|Gammaproteobacteria,2Q9B0@267890|Shewanellaceae	1236|Gammaproteobacteria	P	PFAM Na H antiporter MnhB subunit-related protein	-	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB
k59_530492_3	998674.ATTE01000001_gene736	2.62e-51	165.0	COG1006@1|root,COG1006@2|Bacteria,1RGU1@1224|Proteobacteria,1S6BB@1236|Gammaproteobacteria,462SY@72273|Thiotrichales	72273|Thiotrichales	P	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
k59_530492_4	1282876.BAOK01000001_gene1967	5.09e-70	228.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2TRQ2@28211|Alphaproteobacteria,4BPB8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	nuoN2	-	1.6.5.3	ko:K00343,ko:K05568	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M
k59_1234974_1	1713.JOFV01000010_gene1177	8.54e-38	144.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2GJHB@201174|Actinobacteria,4F1V9@85016|Cellulomonadaceae	201174|Actinobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
k59_2852_1	85643.Tmz1t_3733	4.7e-97	295.0	COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,2VJ7T@28216|Betaproteobacteria,2KU8W@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC-type Fe3 -hydroxamate transport system, periplasmic component	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
k59_1059076_1	1167006.UWK_03323	7.58e-71	230.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,42N2X@68525|delta/epsilon subdivisions,2X7GJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1411016_1	631362.Thi970DRAFT_01084	2.62e-66	223.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1WXQF@135613|Chromatiales	135613|Chromatiales	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_1411016_2	572477.Alvin_1118	1.71e-64	208.0	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales	135613|Chromatiales	P	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
k59_1294839_1	570967.JMLV01000017_gene782	2.68e-29	113.0	COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2U62V@28211|Alphaproteobacteria,2JRXQ@204441|Rhodospirillales	204441|Rhodospirillales	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_1294839_2	509190.Cseg_3851	8.53e-12	65.9	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,2KF19@204458|Caulobacterales	204458|Caulobacterales	V	ABC transporter	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
k59_62072_2	926569.ANT_04990	6.4e-17	76.6	COG1662@1|root,COG1662@2|Bacteria	2|Bacteria	L	PFAM IS1 transposase	-	-	-	ko:K07480	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1
k59_1823106_1	69395.JQLZ01000007_gene1780	3.6e-99	296.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2TU94@28211|Alphaproteobacteria,2KFNZ@204458|Caulobacterales	204458|Caulobacterales	I	PFAM 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III	-	-	2.3.1.207	ko:K16872	-	-	-	-	ko00000,ko01000	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_412960_1	1304865.JAGF01000001_gene370	6.93e-56	190.0	COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria,4F1CX@85016|Cellulomonadaceae	201174|Actinobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
k59_412960_2	446466.Cfla_0851	2.26e-134	390.0	COG0084@1|root,COG0084@2|Bacteria,2GMJJ@201174|Actinobacteria,4F0KS@85016|Cellulomonadaceae	201174|Actinobacteria	L	TatD related DNase	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
k59_1234984_1	393595.ABO_1323	1.16e-87	268.0	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,1RPJA@1236|Gammaproteobacteria,1XM9N@135619|Oceanospirillales	135619|Oceanospirillales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2189
k59_1234984_2	1195246.AGRI_10651	4.99e-18	78.2	2EK1G@1|root,33DRY@2|Bacteria,1NH6C@1224|Proteobacteria,1SGMZ@1236|Gammaproteobacteria,468WX@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3012)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3012
k59_1059086_1	1121952.ATXT01000017_gene824	4.2e-13	67.8	COG2197@1|root,COG2197@2|Bacteria,2I8Y7@201174|Actinobacteria,4FMVM@85023|Microbacteriaceae	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_2881_1	1123319.AUBE01000001_gene1824	5.42e-107	327.0	COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_942663_1	267608.RSc1224	8.08e-10	55.8	COG3242@1|root,COG3242@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2065)	yjeT	-	-	ko:K09937	-	-	-	-	ko00000	-	-	-	DUF2065
k59_942663_2	491952.Mar181_1441	1.86e-66	216.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,1XIEV@135619|Oceanospirillales	135619|Oceanospirillales	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_942663_3	859657.RPSI07_2155	3.05e-12	70.1	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,1K462@119060|Burkholderiaceae	28216|Betaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
k59_471760_1	631362.Thi970DRAFT_01084	1.28e-251	714.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1WXQF@135613|Chromatiales	135613|Chromatiales	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_1763154_1	1033802.SSPSH_003752	2.29e-29	112.0	COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,1RN94@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
k59_1763154_2	1479237.JMLY01000001_gene1899	1.93e-11	63.9	COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,1S3RM@1236|Gammaproteobacteria,467G5@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1235002_1	1168065.DOK_03858	4.18e-40	146.0	COG0438@1|root,COG0438@2|Bacteria,1NA28@1224|Proteobacteria,1RQBV@1236|Gammaproteobacteria,1J4MM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Domain of unknown function (DUF3524)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3524,Glyco_trans_1_4,Glycos_transf_1
k59_62104_1	580332.Slit_0693	1.16e-11	65.5	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,2VR85@28216|Betaproteobacteria,44VY5@713636|Nitrosomonadales	28216|Betaproteobacteria	Q	MlaC protein	ttg2D	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
k59_62104_2	314345.SPV1_13387	1.42e-25	103.0	COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria	1224|Proteobacteria	S	Bile acid sodium symporter	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
k59_2902_1	479434.Sthe_3342	1.23e-61	211.0	COG2217@1|root,COG2217@2|Bacteria,2G5S4@200795|Chloroflexi,27YT0@189775|Thermomicrobia	189775|Thermomicrobia	P	E1-E2 ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
k59_942678_1	768671.ThimaDRAFT_2349	6.46e-18	77.8	2ECSY@1|root,336QI@2|Bacteria,1N9AZ@1224|Proteobacteria,1S9XM@1236|Gammaproteobacteria,1WYWD@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_942678_2	228410.NE2214	1.54e-54	179.0	COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2VID5@28216|Betaproteobacteria,37209@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Protein of unknown function (DUF815)	-	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
k59_63200_1	590998.Celf_2737	8.63e-53	179.0	COG0064@1|root,COG0064@2|Bacteria,2GJJH@201174|Actinobacteria,4F0FH@85016|Cellulomonadaceae	201174|Actinobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_63200_2	926564.KI911710_gene2857	8.59e-108	325.0	COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,4F3GC@85017|Promicromonosporaceae	201174|Actinobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	GO:0008150,GO:0040007	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_1824199_1	1240349.ANGC01000115_gene2976	1.55e-127	374.0	COG2801@1|root,COG2801@2|Bacteria,2I8Z0@201174|Actinobacteria,4G5S6@85025|Nocardiaceae	201174|Actinobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_120388_2	1123065.ATWL01000001_gene506	4.53e-33	119.0	COG1881@1|root,COG1881@2|Bacteria,2GMIG@201174|Actinobacteria	201174|Actinobacteria	S	Phospholipid-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
k59_472530_1	204669.Acid345_1270	1.95e-91	286.0	COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria,2JME5@204432|Acidobacteriia	204432|Acidobacteriia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
k59_1705355_2	1279015.KB908455_gene1398	6.73e-08	52.4	COG3223@1|root,COG3223@2|Bacteria,1N0MS@1224|Proteobacteria,1S9SN@1236|Gammaproteobacteria,1Y5WJ@135624|Aeromonadales	135624|Aeromonadales	S	Phosphate-starvation-inducible E	-	-	-	ko:K13256	-	-	-	-	ko00000	-	-	-	PsiE
k59_472532_1	234267.Acid_3767	1.94e-23	91.3	COG1942@1|root,COG1942@2|Bacteria	2|Bacteria	S	isomerase activity	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
k59_63226_1	261292.Nit79A3_0032	1.6e-61	207.0	COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,2VKCX@28216|Betaproteobacteria,3722M@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1235775_1	493475.GARC_4235	1.33e-75	251.0	COG3356@1|root,COG3356@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
k59_1705369_1	472759.Nhal_2749	4.84e-71	220.0	COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,1RNSJ@1236|Gammaproteobacteria,1WY08@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4_21
k59_238118_1	713586.KB900536_gene310	7.94e-79	241.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1WX5A@135613|Chromatiales	135613|Chromatiales	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_238118_2	1266914.ATUK01000002_gene488	1.62e-09	56.6	COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,1S90K@1236|Gammaproteobacteria,1WYEK@135613|Chromatiales	135613|Chromatiales	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_531350_1	1172188.KB911820_gene2782	3.83e-55	179.0	COG3428@1|root,COG3428@2|Bacteria,2GK6Y@201174|Actinobacteria,4FGFN@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
k59_531350_2	367299.JOEE01000004_gene1119	1.28e-33	124.0	COG2755@1|root,COG2755@2|Bacteria,2IC8X@201174|Actinobacteria,4FI2P@85021|Intrasporangiaceae	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
k59_765767_1	522306.CAP2UW1_1241	5.62e-86	268.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2VNS5@28216|Betaproteobacteria	28216|Betaproteobacteria	E	LeuA allosteric (dimerisation) domain	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_943858_1	296591.Bpro_3989	9.11e-27	108.0	COG0438@1|root,COG0438@2|Bacteria,1R3TV@1224|Proteobacteria,2VNZ7@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
k59_1353131_1	187272.Mlg_2533	9.63e-99	310.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1WW1J@135613|Chromatiales	135613|Chromatiales	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	-	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_531354_1	1415778.JQMM01000001_gene1094	8.91e-29	124.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,1J4NX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	von Willebrand factor (vWF) type A domain	norD	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_2
k59_707493_1	765914.ThisiDRAFT_2757	8.98e-94	295.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_1470496_1	335543.Sfum_0771	6.3e-55	176.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,42SJ8@68525|delta/epsilon subdivisions,2WP5B@28221|Deltaproteobacteria,2MQHT@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
k59_472571_1	56110.Oscil6304_1842	3.55e-09	56.6	COG4636@1|root,COG4636@2|Bacteria,1G5C5@1117|Cyanobacteria,1HFD4@1150|Oscillatoriales	1117|Cyanobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
k59_472571_2	768671.ThimaDRAFT_2255	2.75e-37	126.0	COG2002@1|root,COG2002@2|Bacteria,1N3BE@1224|Proteobacteria,1SF49@1236|Gammaproteobacteria,1WZF4@135613|Chromatiales	135613|Chromatiales	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
k59_1529086_2	1301098.PKB_4325	1.8e-11	60.1	COG4274@1|root,COG4274@2|Bacteria,1RHJ3@1224|Proteobacteria	1224|Proteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
k59_590089_2	105559.Nwat_1092	5.44e-64	204.0	28HJ1@1|root,2Z7UB@2|Bacteria,1R3FN@1224|Proteobacteria,1S37A@1236|Gammaproteobacteria,1WXEJ@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_824511_1	765913.ThidrDRAFT_1758	1.96e-61	190.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,1WYHF@135613|Chromatiales	135613|Chromatiales	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_179067_1	1454004.AW11_03086	3.07e-112	346.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2VIFW@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Pfam Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_531369_2	883126.HMPREF9710_00175	4.34e-59	191.0	COG0546@1|root,COG0546@2|Bacteria,1R903@1224|Proteobacteria,2VJVS@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_1824272_1	471853.Bcav_1246	2.45e-96	306.0	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_238145_1	83406.HDN1F_29120	2.87e-47	161.0	COG1092@1|root,COG1092@2|Bacteria,1RJR8@1224|Proteobacteria,1S69T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
k59_1235800_2	448385.sce6987	7.4e-78	249.0	COG2334@1|root,COG2334@2|Bacteria,1Q18Y@1224|Proteobacteria,42PIW@68525|delta/epsilon subdivisions,2WK5A@28221|Deltaproteobacteria,2YWIH@29|Myxococcales	28221|Deltaproteobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_63287_2	1123065.ATWL01000009_gene1042	6.37e-57	191.0	COG0791@1|root,COG0791@2|Bacteria,2GIWB@201174|Actinobacteria	201174|Actinobacteria	M	PFAM NLP P60 protein	-	-	-	ko:K21471,ko:K21473	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
k59_707508_1	395493.BegalDRAFT_1645	2.96e-34	128.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,460FP@72273|Thiotrichales	72273|Thiotrichales	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_707508_2	1335757.SPICUR_05065	0.000845	41.6	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1WXB7@135613|Chromatiales	135613|Chromatiales	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_1824277_1	298386.PBPRB0593	5.23e-36	138.0	COG3391@1|root,COG3391@2|Bacteria,1R4KD@1224|Proteobacteria,1S1C1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4842)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4842
k59_63297_1	323259.Mhun_1341	1.61e-10	58.9	COG1918@1|root,arCOG02102@2157|Archaea,2Y1P2@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM FeoA	feoA	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
k59_63297_2	267608.RSp0251	1.22e-16	80.9	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria,1K2CU@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Ferrous iron transport protein B	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_472588_1	1386089.N865_06100	1.65e-108	330.0	COG0842@1|root,COG0842@2|Bacteria,2GN6S@201174|Actinobacteria,4FF8R@85021|Intrasporangiaceae	201174|Actinobacteria	U	transport, permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_1296135_1	1049564.TevJSym_ag00200	2.06e-105	310.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1J56Z@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the EPSP synthase family. MurA subfamily	murA	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_296575_2	754477.Q7C_1708	6.57e-83	251.0	COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,4602B@72273|Thiotrichales	72273|Thiotrichales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrD	-	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
k59_1419192_2	1379270.AUXF01000001_gene2488	7.54e-05	48.9	COG0523@1|root,COG0523@2|Bacteria,1ZUT2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Cobalamin synthesis protein cobW C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
k59_1359641_1	1168059.KB899087_gene3836	3.36e-58	188.0	COG1691@1|root,COG1691@2|Bacteria,1REQ7@1224|Proteobacteria,2U8QR@28211|Alphaproteobacteria,3F0D4@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
k59_16322_1	472759.Nhal_3855	9.26e-26	97.1	COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,1SHHF@1236|Gammaproteobacteria,1WZR6@135613|Chromatiales	135613|Chromatiales	S	Zinc-finger domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-CHCC
k59_16322_2	187272.Mlg_2806	4.93e-27	107.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RR6K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	heptosyltransferase	opsX	-	-	ko:K12982	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_1834021_1	1411685.U062_01253	4.62e-153	441.0	COG1253@1|root,COG1253@2|Bacteria,1MWT3@1224|Proteobacteria,1RQBC@1236|Gammaproteobacteria,1J8SC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function DUF21	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
k59_1834022_1	1121920.AUAU01000012_gene2678	4.03e-11	69.3	COG1331@1|root,COG1331@2|Bacteria,3Y3AA@57723|Acidobacteria	57723|Acidobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
k59_72921_1	1033734.CAET01000069_gene2332	0.000112	50.1	COG1480@1|root,COG1480@2|Bacteria,1TR1A@1239|Firmicutes,4HAEZ@91061|Bacilli,1ZANS@1386|Bacillus	91061|Bacilli	S	membrane-associated HD superfamily hydrolase	yqfF	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
k59_596539_1	526225.Gobs_2237	3.32e-64	214.0	COG2059@1|root,COG2059@2|Bacteria,2IB69@201174|Actinobacteria,4ET58@85013|Frankiales	201174|Actinobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_1594016_1	331678.Cphamn1_1358	4.56e-90	282.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
k59_249938_1	1298867.AUES01000007_gene4978	1.53e-71	233.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,3JT9M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	nikA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1419198_1	768671.ThimaDRAFT_4169	4.21e-94	296.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,1WXFC@135613|Chromatiales	135613|Chromatiales	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1419198_2	1120968.AUBX01000010_gene1209	2.4e-29	113.0	COG1878@1|root,COG1878@2|Bacteria,4NFYB@976|Bacteroidetes,47XKZ@768503|Cytophagia	976|Bacteroidetes	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
k59_249940_1	288000.BBta_3672	2.59e-38	134.0	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,2U72E@28211|Alphaproteobacteria,3JYQN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Sulfur oxidation protein SoxY	soxY	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY
k59_16339_1	220664.PFL_1504	1.18e-89	270.0	COG2519@1|root,COG2519@2|Bacteria,1QU0A@1224|Proteobacteria,1S03F@1236|Gammaproteobacteria,1YN2R@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	J	Spermine/spermidine synthase domain	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
k59_831595_1	1249627.D779_0228	1.69e-58	198.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_1244739_1	886379.AEWI01000012_gene1055	2.49e-62	208.0	COG1053@1|root,COG1053@2|Bacteria,4NFDU@976|Bacteroidetes,2FM67@200643|Bacteroidia,3XJBI@558415|Marinilabiliaceae	976|Bacteroidetes	C	Fumarate reductase flavoprotein C-term	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1244739_2	1353529.M899_2136	2.29e-06	50.4	2CAZH@1|root,2Z7RU@2|Bacteria,1N3AE@1224|Proteobacteria,42UBH@68525|delta/epsilon subdivisions,2MT2C@213481|Bdellovibrionales,2WQ56@28221|Deltaproteobacteria	213481|Bdellovibrionales	-	-	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	-
k59_771355_1	1122611.KB904003_gene8071	1.35e-62	211.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4EH3S@85012|Streptosporangiales	201174|Actinobacteria	I	AMP-binding enzyme	fadD2	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_16362_1	862751.SACTE_2505	7.36e-120	352.0	COG1208@1|root,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria	201174|Actinobacteria	JM	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits	manC	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
k59_16365_1	316058.RPB_2892	6.21e-39	144.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2TS9E@28211|Alphaproteobacteria,3JTU7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_596560_1	246197.MXAN_4473	4.48e-24	98.2	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,42M98@68525|delta/epsilon subdivisions,2WMKB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Integrase catalytic	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve
k59_596560_2	314278.NB231_15718	7.04e-33	117.0	COG2963@1|root,COG2963@2|Bacteria,1N8Y3@1224|Proteobacteria	1224|Proteobacteria	L	PFAM transposase IS3 IS911 family protein	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_714469_1	94624.Bpet2763	5.9e-16	76.3	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2VHAQ@28216|Betaproteobacteria,3T1MU@506|Alcaligenaceae	28216|Betaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
k59_714469_2	1249627.D779_2770	8.61e-134	391.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1WW0V@135613|Chromatiales	135613|Chromatiales	M	lipoprotein releasing system, transmembrane protein, LolC E family	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_249977_1	1163617.SCD_n01211	1.55e-11	63.2	COG3302@1|root,COG3302@2|Bacteria,1MWY1@1224|Proteobacteria,2VN4W@28216|Betaproteobacteria	28216|Betaproteobacteria	S	DMSO reductase anchor subunit (DmsC)	dmsC	-	-	ko:K21309	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001	-	-	-	DmsC
k59_249977_2	1049564.TevJSym_aj00800	5.76e-82	248.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,1SYJH@1236|Gammaproteobacteria,1J9UJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S binding domain	-	-	-	ko:K00184,ko:K21308	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001	5.A.3	-	-	Fer4_11,Fer4_4,Fer4_7,Molydop_binding
k59_538124_1	395493.BegalDRAFT_1040	5.07e-10	60.5	2DS2H@1|root,33E82@2|Bacteria,1NPEB@1224|Proteobacteria,1SRXB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_538124_2	1123261.AXDW01000005_gene2696	6.31e-32	127.0	COG0664@1|root,COG1033@1|root,COG0664@2|Bacteria,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1X3P5@135614|Xanthomonadales	135614|Xanthomonadales	T	Sterol-sensing domain of SREBP cleavage-activation	-	-	-	-	-	-	-	-	-	-	-	-	MMPL,cNMP_binding
k59_1069221_1	323848.Nmul_A1667	5.21e-47	161.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,2VHKM@28216|Betaproteobacteria,3735W@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Hydrogenase formation hypA family	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
k59_714480_1	592028.GCWU000321_01585	5.51e-18	87.0	COG2253@1|root,COG2253@2|Bacteria,1TSFX@1239|Firmicutes,4H48J@909932|Negativicutes	909932|Negativicutes	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
k59_479321_1	1238182.C882_4245	5.39e-52	179.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,2U1B0@28211|Alphaproteobacteria,2JR9F@204441|Rhodospirillales	204441|Rhodospirillales	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
k59_479321_2	631454.N177_3896	8.72e-25	95.1	2EDYZ@1|root,337TS@2|Bacteria,1N7SA@1224|Proteobacteria,2UNBF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_479321_3	631454.N177_3897	4e-21	93.2	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,2TSJC@28211|Alphaproteobacteria,1JQ01@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Proton-conducting membrane transporter	nuoL3	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_366487_2	1121405.dsmv_0419	6.44e-48	159.0	COG1309@1|root,COG1309@2|Bacteria,1R4VA@1224|Proteobacteria,42PZX@68525|delta/epsilon subdivisions,2WK4I@28221|Deltaproteobacteria,2MI67@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_714485_1	713587.THITH_10125	9.68e-34	129.0	COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,1RNAP@1236|Gammaproteobacteria,1WW6T@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase family 4	-	-	-	ko:K13007	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
k59_186220_1	580332.Slit_1694	4.12e-34	122.0	COG1416@1|root,COG1416@2|Bacteria,1RE8C@1224|Proteobacteria,2VV8B@28216|Betaproteobacteria	28216|Betaproteobacteria	S	DsrE/DsrF-like family	-	-	-	ko:K09004	-	-	-	-	ko00000	-	-	-	DrsE
k59_596563_2	1349820.M707_16705	1.94e-145	460.0	COG2120@1|root,COG5492@1|root,COG5640@1|root,COG2120@2|Bacteria,COG5492@2|Bacteria,COG5640@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,PIG-L,VCBS
k59_596563_3	1122137.AQXF01000005_gene1041	2.98e-12	67.8	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,2TVJ1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416,Malt_amylase_C
k59_1834095_1	751945.Theos_1513	8.81e-52	179.0	COG4799@1|root,COG4799@2|Bacteria,1WI9K@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
k59_1305916_1	1184267.A11Q_1402	4.22e-125	375.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2MTSI@213481|Bdellovibrionales,2WKBU@28221|Deltaproteobacteria	213481|Bdellovibrionales	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1770239_1	1223542.GM1_003_02510	1.09e-42	146.0	COG1259@1|root,COG1259@2|Bacteria,2GN26@201174|Actinobacteria,4GATN@85026|Gordoniaceae	201174|Actinobacteria	S	Bifunctional nuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
k59_1594059_1	760192.Halhy_1181	8.27e-33	131.0	COG3534@1|root,COG3534@2|Bacteria,4NGKW@976|Bacteroidetes,1IR5F@117747|Sphingobacteriia	976|Bacteroidetes	G	Alpha-L-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C,CBM_4_9
k59_1069230_1	298655.KI912266_gene3366	1.95e-163	477.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4EUTF@85013|Frankiales	201174|Actinobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_72997_1	1122138.AQUZ01000039_gene8041	2.18e-112	330.0	COG4974@1|root,COG4974@2|Bacteria,2I9JH@201174|Actinobacteria,4DU7P@85009|Propionibacteriales	201174|Actinobacteria	L	Phage integrase SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_186228_1	1121405.dsmv_0112	5.82e-68	217.0	COG2234@1|root,COG2234@2|Bacteria,1MXZS@1224|Proteobacteria,42S82@68525|delta/epsilon subdivisions,2WNJE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM peptidase M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
k59_127531_1	446469.Sked_07880	4.35e-71	226.0	COG0248@1|root,COG0248@2|Bacteria,2GJBN@201174|Actinobacteria	201174|Actinobacteria	FP	Ppx GppA phosphatase	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_831646_1	1045855.DSC_00980	1.33e-06	51.2	COG0594@1|root,COG0594@2|Bacteria,1NGQJ@1224|Proteobacteria,1SXVV@1236|Gammaproteobacteria,1X6VJ@135614|Xanthomonadales	135614|Xanthomonadales	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
k59_831646_2	672.VV93_v1c30080	1.15e-16	72.0	COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,1SGDJ@1236|Gammaproteobacteria,1XYVN@135623|Vibrionales	135623|Vibrionales	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
k59_831646_3	519989.ECTPHS_07601	1.36e-18	86.3	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1WW6C@135613|Chromatiales	135613|Chromatiales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_420509_1	338969.Rfer_0632	0.000106	43.9	COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,2VHMK@28216|Betaproteobacteria,4AB3F@80864|Comamonadaceae	28216|Betaproteobacteria	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	fliD	-	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,FliD_C,FliD_N
k59_420509_2	1049564.TevJSym_aa01600	5.89e-12	65.1	COG1334@1|root,COG1334@2|Bacteria,1NH9T@1224|Proteobacteria,1RW0P@1236|Gammaproteobacteria,1J79K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	N	FlaG protein	-	-	-	ko:K06603	-	-	-	-	ko00000,ko02035	-	-	-	FlaG
k59_1359713_1	1249627.D779_1965	3.17e-69	225.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,1T2DW@1236|Gammaproteobacteria,1X2PB@135613|Chromatiales	135613|Chromatiales	EQ	PFAM Hydantoinase B oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_1305945_2	267747.PPA0922	4.15e-13	70.5	COG1207@1|root,COG1207@2|Bacteria,2H30P@201174|Actinobacteria	201174|Actinobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	-	-	2.7.7.23,2.7.7.83	ko:K00972	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00361,M00362	R00416	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	-
k59_656505_1	631362.Thi970DRAFT_03648	3.42e-73	243.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,1RPH9@1236|Gammaproteobacteria,1WXJ3@135613|Chromatiales	135613|Chromatiales	E	PFAM Transglutaminase-like	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
k59_1124278_1	1123393.KB891332_gene2757	1.67e-95	293.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2VIH1@28216|Betaproteobacteria,1KS4A@119069|Hydrogenophilales	119069|Hydrogenophilales	P	TrkA-C domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_1536234_1	1097668.BYI23_B001870	5.92e-99	307.0	COG2985@1|root,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,2VMWJ@28216|Betaproteobacteria,1KHE3@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Predicted Permease Membrane Region	-	-	-	ko:K07085	-	-	-	-	ko00000	2.A.81	-	-	Asp-Al_Ex,TrkA_C
k59_128177_1	1267005.KB911256_gene1953	4.07e-125	395.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,3N6A5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Glutamate synthase	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_367367_2	472759.Nhal_1056	6.57e-102	307.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1WWRK@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
k59_1536236_1	226186.BT_3996	6.18e-09	58.2	COG0739@1|root,COG0739@2|Bacteria,4NGHH@976|Bacteroidetes,2FME3@200643|Bacteroidia,4AM3J@815|Bacteroidaceae	976|Bacteroidetes	M	Peptidase, M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_538774_1	1122134.KB893650_gene859	3.03e-92	293.0	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,1RNS0@1236|Gammaproteobacteria,1XICD@135619|Oceanospirillales	135619|Oceanospirillales	C	Cytochrome D1 heme domain	-	-	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_186891_1	335543.Sfum_0901	8.9e-110	332.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,42PRT@68525|delta/epsilon subdivisions,2WIWH@28221|Deltaproteobacteria,2MRDP@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2638	PEPCK_C,PEPCK_N
k59_17634_1	1049564.TevJSym_ah00780	1.15e-38	139.0	28JN1@1|root,2Z9EG@2|Bacteria,1R8TZ@1224|Proteobacteria,1S1S0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_954607_1	96561.Dole_2515	9.51e-105	316.0	COG0438@1|root,COG0438@2|Bacteria,1R8YI@1224|Proteobacteria,42N8I@68525|delta/epsilon subdivisions,2WIYJ@28221|Deltaproteobacteria,2MMJB@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
k59_421133_1	545276.KB898727_gene377	2.56e-85	256.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1WWXG@135613|Chromatiales	135613|Chromatiales	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
k59_832332_1	883080.HMPREF9697_01417	9.11e-25	99.8	COG1416@1|root,COG1416@2|Bacteria,1RBQX@1224|Proteobacteria,2U6BV@28211|Alphaproteobacteria,3JY5C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	ko:K09004	-	-	-	-	ko00000	-	-	-	DrsE
k59_832332_2	2340.JV46_27210	3.31e-17	80.5	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1J7AF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	5'-nucleotidase, C-terminal domain	soxB	-	-	ko:K17224	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	5_nucleotid_C
k59_1712375_1	211165.AJLN01000048_gene5998	3.19e-22	102.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1JKNQ@1189|Stigonemataceae	1117|Cyanobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
k59_954610_1	1397284.AYMN01000015_gene209	3e-36	137.0	COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,1RMYF@1236|Gammaproteobacteria,4010M@613|Serratia	1236|Gammaproteobacteria	C	alcohol dehydrogenase	-	-	1.8.2.2	ko:K19713	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_1770829_1	1163617.SCD_n01242	3.24e-112	341.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
k59_251300_2	1349820.M707_08350	1.17e-18	89.0	COG0477@1|root,COG2814@2|Bacteria,2I5AX@201174|Actinobacteria	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_895643_1	314231.FP2506_17949	1.48e-98	313.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1NS3T@1224|Proteobacteria,2TQYD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_954623_1	56780.SYN_02946	3.2e-91	284.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WK44@28221|Deltaproteobacteria,2MQ56@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	MFS_1,OEP
k59_1070180_1	1227739.Hsw_2333	4.23e-79	258.0	COG1913@1|root,COG1913@2|Bacteria,4PMAZ@976|Bacteroidetes,47JTT@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
k59_954627_2	1137799.GZ78_19285	6.02e-98	292.0	COG3338@1|root,COG3338@2|Bacteria,1PEA6@1224|Proteobacteria,1RSM9@1236|Gammaproteobacteria,1XP0V@135619|Oceanospirillales	135619|Oceanospirillales	P	Eukaryotic-type carbonic anhydrase	-	-	4.2.1.1	ko:K01674	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Carb_anhydrase
k59_1480788_1	525897.Dbac_1087	1.67e-10	59.7	2E8QN@1|root,3331M@2|Bacteria,1ND4I@1224|Proteobacteria,430TR@68525|delta/epsilon subdivisions,2WVZ7@28221|Deltaproteobacteria,2MF52@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1480788_2	1195246.AGRI_01525	7.13e-40	141.0	COG2930@1|root,COG2930@2|Bacteria,1RCH3@1224|Proteobacteria,1S2SV@1236|Gammaproteobacteria,466VF@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Las17-binding protein actin regulator	VPA0371	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_1480788_3	1173029.JH980292_gene1827	1.86e-29	119.0	COG0475@1|root,COG0589@1|root,COG0475@2|Bacteria,COG0589@2|Bacteria,1G00D@1117|Cyanobacteria,1H9SU@1150|Oscillatoriales	1117|Cyanobacteria	PT	'Kef-type K transport	napA	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,Usp
k59_771920_1	526227.Mesil_1353	9.91e-08	57.4	COG2074@1|root,COG2074@2|Bacteria,1WI2U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	2-phosphoglycerate kinase	-	-	-	ko:K05715	-	-	R02664	RC00002,RC00017	ko00000,ko01000	-	-	-	AAA_33,ATP-cone
k59_771920_2	1049564.TevJSym_ab01230	1.44e-104	312.0	COG2242@1|root,COG2242@2|Bacteria,1R79F@1224|Proteobacteria,1RY3Z@1236|Gammaproteobacteria,1J8AJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_722602_4	491952.Mar181_3529	3.37e-19	84.7	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,1XK2G@135619|Oceanospirillales	135619|Oceanospirillales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
k59_1317475_1	555088.DealDRAFT_1207	1.46e-51	177.0	COG0367@1|root,COG0367@2|Bacteria,1TRPB@1239|Firmicutes,247YA@186801|Clostridia	186801|Clostridia	E	Asparagine synthase, glutamine-hydrolyzing	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7,NAD_synthase
k59_1778527_1	757424.Hsero_2962	1.42e-12	71.6	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2VIND@28216|Betaproteobacteria,472T3@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
k59_778232_1	1120972.AUMH01000004_gene1395	2.18e-89	290.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,4H9S7@91061|Bacilli,27842@186823|Alicyclobacillaceae	91061|Bacilli	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A
k59_28686_1	479433.Caci_6678	1.95e-47	167.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_28686_2	1120942.AUBM01000012_gene1515	1.44e-05	47.0	COG1309@1|root,COG1309@2|Bacteria,2GP92@201174|Actinobacteria,4D4UD@85005|Actinomycetales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_262600_1	870187.Thini_4030	2.04e-73	246.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,4600V@72273|Thiotrichales	72273|Thiotrichales	E	Vitamin B12 dependent methionine synthase, activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_1317478_1	674977.VMC_34250	1.01e-25	107.0	COG4531@1|root,COG4531@2|Bacteria,1QTTI@1224|Proteobacteria,1RMRJ@1236|Gammaproteobacteria,1XT4D@135623|Vibrionales	135623|Vibrionales	P	COG4531 ABC-type Zn2 transport system, periplasmic component surface adhesin	znuA	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
k59_1131056_1	1121405.dsmv_2875	1.75e-50	164.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,42SNY@68525|delta/epsilon subdivisions,2WP2P@28221|Deltaproteobacteria,2MJU1@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
k59_1544017_1	1306174.JODP01000021_gene201	6.22e-100	309.0	COG3153@1|root,COG3547@1|root,COG3153@2|Bacteria,COG3547@2|Bacteria,2HASG@201174|Actinobacteria	201174|Actinobacteria	L	transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1255837_1	1385519.N801_07480	1.39e-44	153.0	2BGRN@1|root,32AQR@2|Bacteria,2IIE3@201174|Actinobacteria,4FF4I@85021|Intrasporangiaceae	201174|Actinobacteria	Q	2-nitropropane	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
k59_194542_1	1347086.CCBA010000004_gene4426	1.29e-09	57.8	COG2321@1|root,COG2321@2|Bacteria,1TQKF@1239|Firmicutes,4HB7I@91061|Bacilli,1ZCSY@1386|Bacillus	91061|Bacilli	S	Putative neutral zinc metallopeptidase	XK27_03670	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
k59_1544019_1	1304865.JAGF01000001_gene4001	8.58e-69	215.0	2DQQK@1|root,33842@2|Bacteria,2GS39@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
k59_604706_1	247633.GP2143_09992	5.76e-17	82.0	COG0153@1|root,COG0153@2|Bacteria,1MVQD@1224|Proteobacteria,1RQ0C@1236|Gammaproteobacteria,1J7W7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Galactokinase galactose-binding signature	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
k59_664181_1	765914.ThisiDRAFT_1631	3.29e-87	271.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1WVZB@135613|Chromatiales	135613|Chromatiales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_428767_1	1121927.GOHSU_01_00350	3.3e-25	108.0	COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,4GC8K@85026|Gordoniaceae	201174|Actinobacteria	KLT	Protein tyrosine kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_1013211_1	1304865.JAGF01000001_gene2760	1.02e-68	229.0	COG0272@1|root,COG0272@2|Bacteria,2GJUY@201174|Actinobacteria,4F0QA@85016|Cellulomonadaceae	201174|Actinobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
k59_839969_1	243233.MCA2272	1.51e-203	568.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1XE7R@135618|Methylococcales	135618|Methylococcales	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
k59_839969_2	357804.Ping_3431	0.000551	41.2	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,1S20I@1236|Gammaproteobacteria,2QIZS@267894|Psychromonadaceae	1236|Gammaproteobacteria	E	Small subunit of acetolactate synthase	ilvH	GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1906,iECNA114_1301.ECNA114_0072,iEcSMS35_1347.EcSMS35_0084,iG2583_1286.G2583_0082,iSFxv_1172.SFxv_0077,iUTI89_1310.UTI89_C0086	ACT,ACT_5,ALS_ss_C
k59_1255849_1	987059.RBXJA2T_12142	2.35e-96	296.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,1KJCV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1845662_1	1123228.AUIH01000026_gene3880	8.13e-23	99.8	COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,1RN6T@1236|Gammaproteobacteria,1XHZ3@135619|Oceanospirillales	135619|Oceanospirillales	N	The M ring may be actively involved in energy transduction	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
k59_1845662_2	1122212.AULO01000009_gene860	1.57e-17	77.8	COG1677@1|root,COG1677@2|Bacteria,1N6RZ@1224|Proteobacteria,1SD52@1236|Gammaproteobacteria,1XKZR@135619|Oceanospirillales	135619|Oceanospirillales	N	Flagellar hook-basal body complex protein FliE	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
k59_1081815_1	1395516.PMO01_20445	2.33e-148	429.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	belongs to the aspartokinase family	lysC	GO:0003674,GO:0003824,GO:0004072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0044237	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
k59_1081818_2	870187.Thini_0482	1.1e-70	228.0	COG1100@1|root,COG1100@2|Bacteria,1R1W9@1224|Proteobacteria,1SK3H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF697,MMR_HSR1
k59_378068_1	1449069.JMLO01000010_gene428	5.39e-113	336.0	COG0686@1|root,COG0686@2|Bacteria,2GJ6G@201174|Actinobacteria,4FURB@85025|Nocardiaceae	201174|Actinobacteria	E	Belongs to the AlaDH PNT family	ald	GO:0000286,GO:0001666,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009628,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030312,GO:0036293,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050896,GO:0055114,GO:0070482,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_378068_2	35754.JNYJ01000040_gene1514	2.8e-17	80.1	COG2267@1|root,COG2267@2|Bacteria,2IFK6@201174|Actinobacteria,4DD5A@85008|Micromonosporales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_1544033_1	933262.AXAM01000004_gene2355	8.39e-98	296.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NM8@68525|delta/epsilon subdivisions,2WIWB@28221|Deltaproteobacteria,2MIKK@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_1490605_1	1049564.TevJSym_bo00150	2.79e-06	49.3	COG1522@1|root,COG1522@2|Bacteria,1RHD9@1224|Proteobacteria,1S6TQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional	nirD	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
k59_1490605_2	1049564.TevJSym_bo00160	7.36e-81	251.0	COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,1RYUT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Heme d1 biosynthesis protein NirF	nirF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K19345	-	-	-	-	ko00000	-	-	-	Cytochrom_D1
k59_1845675_1	96561.Dole_0155	4.88e-89	284.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42MI5@68525|delta/epsilon subdivisions,2WITQ@28221|Deltaproteobacteria,2MI9V@213118|Desulfobacterales	28221|Deltaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1,ECH_2
k59_1255866_1	1249627.D779_2089	1.63e-07	57.8	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,1SYJF@1236|Gammaproteobacteria,1WXTI@135613|Chromatiales	135613|Chromatiales	S	PFAM Ankyrin	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4,Ank_5
k59_778260_1	1041139.KB902687_gene1250	3.47e-113	343.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,4B9EB@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Arylsulfatase	aslA	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_722644_1	1151122.AQYD01000007_gene501	1.53e-50	164.0	COG0315@1|root,COG0315@2|Bacteria,2IHR6@201174|Actinobacteria,4FNWJ@85023|Microbacteriaceae	201174|Actinobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
k59_487552_1	1384056.N787_11465	2.3e-155	473.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,1RSHX@1236|Gammaproteobacteria,1X3T3@135614|Xanthomonadales	135614|Xanthomonadales	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_664205_1	765912.Thimo_1050	2.7e-64	215.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WXAR@135613|Chromatiales	135613|Chromatiales	NU	TIGRFAM type IV-A pilus assembly ATPase PilB	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
k59_28757_1	3075.A0A087SCL2	3.63e-23	103.0	COG0154@1|root,KOG1471@1|root,KOG1211@2759|Eukaryota,KOG1471@2759|Eukaryota,37J40@33090|Viridiplantae	33090|Viridiplantae	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts and mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho- Glu-tRNA(Gln)	GATA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_84534_1	1123258.AQXZ01000018_gene730	7.97e-36	135.0	COG2508@1|root,COG2508@2|Bacteria,2GR38@201174|Actinobacteria,4FZ5F@85025|Nocardiaceae	201174|Actinobacteria	QT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
k59_1081841_1	207954.MED92_08752	1.62e-16	78.6	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1XIBE@135619|Oceanospirillales	135619|Oceanospirillales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_1081841_2	565045.NOR51B_168	8.58e-23	95.1	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0000217,GO:0000400,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
k59_1131105_1	1408473.JHXO01000010_gene3592	5.29e-13	75.9	COG2373@1|root,COG2373@2|Bacteria,4NEW9@976|Bacteroidetes,2FP6Z@200643|Bacteroidia	976|Bacteroidetes	S	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl
k59_194582_1	1408322.JHYK01000001_gene1462	6.5e-52	174.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,27JMB@186928|unclassified Lachnospiraceae	186801|Clostridia	S	TIGR00268 family	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,NAD_synthase,QueC
k59_840000_1	1123279.ATUS01000001_gene2477	3.08e-07	53.5	COG0672@1|root,COG0672@2|Bacteria,1N48M@1224|Proteobacteria,1S7GF@1236|Gammaproteobacteria,1J6PW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0672 High-affinity Fe2 Pb2 permease	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
k59_840000_2	498211.CJA_3509	5.7e-42	140.0	COG4633@1|root,COG4633@2|Bacteria,1N6VB@1224|Proteobacteria,1SDG5@1236|Gammaproteobacteria,1FHK7@10|Cellvibrio	1236|Gammaproteobacteria	S	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
k59_840000_3	1168065.DOK_17540	2.31e-21	93.2	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,1T1G3@1236|Gammaproteobacteria,1JC2S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Two-component sensor kinase N-terminal	qseC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K07645	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
k59_1662632_1	246437.XP_006147820.1	0.000873	46.2	COG0096@1|root,COG5599@1|root,KOG3528@1|root,KOG0792@2759|Eukaryota,KOG1754@2759|Eukaryota,KOG3528@2759|Eukaryota,39RVQ@33154|Opisthokonta,3BM4C@33208|Metazoa,3CRUD@33213|Bilateria,489IZ@7711|Chordata,49819@7742|Vertebrata,3J3IC@40674|Mammalia,35DUI@314146|Euarchontoglires	33208|Metazoa	T	kinase non-catalytic C-lobe domain	FRMPD2	GO:0003674,GO:0005488,GO:0005543,GO:0005545,GO:0005575,GO:0005623,GO:0005886,GO:0005911,GO:0005923,GO:0007043,GO:0008150,GO:0008289,GO:0009987,GO:0016020,GO:0016043,GO:0016323,GO:0022607,GO:0030054,GO:0034329,GO:0034330,GO:0035091,GO:0043167,GO:0043168,GO:0043296,GO:0043297,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045216,GO:0070160,GO:0070830,GO:0071840,GO:0071944,GO:0098590	-	-	-	-	-	-	-	-	-	-	FERM_C,FERM_M,FERM_N,KIND,PDZ
k59_1662632_2	765912.Thimo_3366	4.38e-07	50.8	COG3448@1|root,COG3448@2|Bacteria,1QHBG@1224|Proteobacteria,1S7QY@1236|Gammaproteobacteria,1WYGM@135613|Chromatiales	135613|Chromatiales	T	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_194584_1	335543.Sfum_0460	1.08e-127	370.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2WJ4U@28221|Deltaproteobacteria,2MQPY@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF987.Gmet_1360	Ldh_1_C,Ldh_1_N
k59_1081850_1	1121403.AUCV01000002_gene611	1.13e-35	128.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,42SDX@68525|delta/epsilon subdivisions,2WP41@28221|Deltaproteobacteria,2MK62@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_1081850_2	439481.Aboo_0966	0.000389	42.4	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,3F2GK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	tRNA-splicing ligase RtcB	rtcB	GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Intein_splicing,LAGLIDADG_3,RtcB
k59_604749_1	582744.Msip34_2218	4.05e-31	123.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,2KKSP@206350|Nitrosomonadales	206350|Nitrosomonadales	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_604749_2	85643.Tmz1t_2656	1.6e-10	60.8	COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,2VI4R@28216|Betaproteobacteria,2KVFV@206389|Rhodocyclales	206389|Rhodocyclales	F	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation	-	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
k59_840003_1	1123261.AXDW01000015_gene3418	2.34e-72	228.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1X2ZP@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
k59_840003_2	1249627.D779_3326	8.09e-26	102.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1WWC4@135613|Chromatiales	135613|Chromatiales	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_1778601_1	935261.JAGL01000079_gene1065	1.16e-20	97.1	COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2TR59@28211|Alphaproteobacteria,43KZJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Transposase C of IS166 homeodomain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_1192747_1	33876.JNXY01000020_gene4320	5.57e-17	82.0	COG0637@1|root,COG0637@2|Bacteria,2IQD3@201174|Actinobacteria,4DI2I@85008|Micromonosporales	201174|Actinobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
k59_1255911_1	1197706.AKKK01000043_gene1723	6.44e-21	97.1	COG1404@1|root,COG2356@1|root,COG1404@2|Bacteria,COG2356@2|Bacteria,2GJ38@201174|Actinobacteria	201174|Actinobacteria	L	Protein of unknown function (DUF1524)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1524,Excalibur
k59_311579_1	1207063.P24_12981	2.11e-89	275.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,2TR9A@28211|Alphaproteobacteria,2JQCQ@204441|Rhodospirillales	204441|Rhodospirillales	U	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
k59_1662646_1	446466.Cfla_1660	4.04e-108	323.0	COG4825@1|root,COG4825@2|Bacteria,2GPAA@201174|Actinobacteria,4F0E1@85016|Cellulomonadaceae	201174|Actinobacteria	S	Thiamine pyrophosphokinase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TPPK_C
k59_1662646_2	593907.Celgi_1935	5.22e-08	53.1	2D1T0@1|root,32TBA@2|Bacteria,2I8E5@201174|Actinobacteria,4F1CG@85016|Cellulomonadaceae	201174|Actinobacteria	S	Copper transport outer membrane protein, MctB	mctB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0008150,GO:0009279,GO:0015267,GO:0015288,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0044425,GO:0044462,GO:0044464,GO:0046930,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098796	-	-	-	-	-	-	-	-	-	-	MctB
k59_1368170_1	247639.MGP2080_04255	1.22e-72	241.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_722665_1	1033802.SSPSH_002704	1.8e-66	207.0	COG2343@1|root,COG2343@2|Bacteria,1RJ3M@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
k59_1193538_1	880072.Desac_1300	4.74e-85	265.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,42M56@68525|delta/epsilon subdivisions,2WJ8W@28221|Deltaproteobacteria,2MQZM@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM isocitrate dehydrogenase, NADP-dependent	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_966413_1	1122239.AULS01000004_gene1404	6.91e-13	71.6	COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,4FMX0@85023|Microbacteriaceae	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	bioM	-	-	ko:K16784	ko02010,map02010	M00581	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25.1	-	-	ABC_tran
k59_966413_2	1045009.AFXQ01000011_gene474	2.77e-73	231.0	COG1108@1|root,COG1108@2|Bacteria,2GJ7H@201174|Actinobacteria,1W8TI@1268|Micrococcaceae	201174|Actinobacteria	P	ABC 3 transport family	mntB	-	-	ko:K02075,ko:K09819	-	M00243,M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
k59_1544878_1	765912.Thimo_1422	1.01e-106	320.0	COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,1RQQA@1236|Gammaproteobacteria,1X0G6@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_1132016_1	110319.CF8_0950	6.86e-83	262.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4DPNX@85009|Propionibacteriales	201174|Actinobacteria	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
k59_546959_1	1267533.KB906734_gene3745	1.64e-08	55.1	COG1595@1|root,COG1595@2|Bacteria,3Y6JW@57723|Acidobacteria,2JMMG@204432|Acidobacteriia	204432|Acidobacteriia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_379218_1	580332.Slit_1709	4.92e-100	301.0	COG3302@1|root,COG3302@2|Bacteria,1MWY1@1224|Proteobacteria,2VN4W@28216|Betaproteobacteria,44WEC@713636|Nitrosomonadales	28216|Betaproteobacteria	S	DMSO reductase anchor subunit (DmsC)	dmsC	-	-	ko:K21309	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001	-	-	-	DmsC
k59_1013948_1	1713.JOFV01000023_gene1345	2.32e-54	190.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,2GKQ8@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_tranf_2_3,Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2
k59_1663491_1	879212.DespoDRAFT_01479	5e-68	219.0	COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria,42VIF@68525|delta/epsilon subdivisions,2WRY1@28221|Deltaproteobacteria,2MQ11@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_966420_1	1249627.D779_2413	1.82e-162	470.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1WVVK@135613|Chromatiales	135613|Chromatiales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_1082906_1	394221.Mmar10_2201	1.07e-84	258.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2TRNV@28211|Alphaproteobacteria,43WR2@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_779048_1	105559.Nwat_1701	8.52e-62	209.0	COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,1RRS6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_30114_1	880072.Desac_0544	3.03e-87	285.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MSJC@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	por	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1318681_1	59538.XP_005977975.1	5.96e-121	359.0	COG2513@1|root,KOG1260@2759|Eukaryota	59538.XP_005977975.1|-	G	isocitrate lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1318681_2	997346.HMPREF9374_3374	1.43e-34	131.0	COG2225@1|root,COG2225@2|Bacteria,1TPE8@1239|Firmicutes,4H9ST@91061|Bacilli,27BGX@186824|Thermoactinomycetaceae	91061|Bacilli	C	Malate synthase	aceB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_144693_2	536019.Mesop_1606	8.56e-89	273.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2TQPB@28211|Alphaproteobacteria,43I00@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_921290_1	1095767.CAHD01000080_gene2734	1.9e-22	100.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria,4F266@85016|Cellulomonadaceae	201174|Actinobacteria	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
k59_1139244_1	595460.RRSWK_04882	2.13e-58	192.0	COG0631@1|root,COG0631@2|Bacteria	2|Bacteria	T	protein serine/threonine phosphatase activity	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
k59_1139244_2	2340.JV46_09570	1.18e-20	87.8	COG2928@1|root,COG2928@2|Bacteria,1R79M@1224|Proteobacteria,1S6CC@1236|Gammaproteobacteria,1J7B4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
k59_848842_1	1304865.JAGF01000001_gene1277	4.68e-78	248.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,4F0NT@85016|Cellulomonadaceae	201174|Actinobacteria	KLT	PFAM Serine threonine-protein kinase-like domain	pknA	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_392917_1	247633.GP2143_15876	2.01e-62	214.0	COG3072@1|root,COG3072@2|Bacteria,1PI5T@1224|Proteobacteria,1RMPZ@1236|Gammaproteobacteria,1J501@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Adenylate cyclase	cyaA	GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0052652,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.1	ko:K05851	ko00230,ko02026,ko05111,map00230,map02026,map05111	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_2672,iECOK1_1307.ECOK1_4253,iECS88_1305.ECS88_4229,iUMN146_1321.UM146_19155,iUTI89_1310.UTI89_C4365	Adenyl_cycl_N,Adenylate_cycl
k59_785814_1	211114.JOEF01000002_gene3944	3.17e-06	56.2	COG2409@1|root,COG2409@2|Bacteria,2GIRQ@201174|Actinobacteria,4DZH4@85010|Pseudonocardiales	201174|Actinobacteria	S	RND superfamily	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
k59_1436724_1	1205753.A989_07964	2e-89	270.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,1X31M@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_1436724_2	351348.Maqu_2545	5.29e-11	61.6	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,466FX@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_1671629_1	1118153.MOY_16502	1.07e-94	283.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RSHU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	tnpB	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_1671629_2	1217714.F975_01633	2.35e-20	90.9	COG3886@1|root,COG3886@2|Bacteria,1MXJF@1224|Proteobacteria,1RPDK@1236|Gammaproteobacteria,3NRK6@468|Moraxellaceae	1236|Gammaproteobacteria	L	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
k59_320622_1	573370.DMR_36450	1.19e-33	133.0	COG0457@1|root,COG0457@2|Bacteria,1QY6N@1224|Proteobacteria,42XBU@68525|delta/epsilon subdivisions,2WT6X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_496426_1	177439.DP1200	3.87e-150	434.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,2MJ3H@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_613711_2	1168065.DOK_08159	1.71e-20	91.3	COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,1RN0Y@1236|Gammaproteobacteria,1J4GY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	fliC	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_IN,Flagellin_N
k59_437705_1	298653.Franean1_0647	6.05e-72	241.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,2GJ11@201174|Actinobacteria,4ES0J@85013|Frankiales	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
k59_437705_2	1304865.JAGF01000001_gene3042	5.68e-12	72.4	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4F127@85016|Cellulomonadaceae	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1729077_1	1123368.AUIS01000029_gene1289	2.62e-48	171.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,2NBWK@225057|Acidithiobacillales	1236|Gammaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_980436_1	37919.EP51_13930	1.32e-51	180.0	COG1819@1|root,COG1819@2|Bacteria,2GJN7@201174|Actinobacteria,4FY2A@85025|Nocardiaceae	201174|Actinobacteria	CG	glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,UDPGT
k59_1729078_1	1335757.SPICUR_02735	1.43e-48	174.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1WWHC@135613|Chromatiales	135613|Chromatiales	J	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
k59_1860933_1	335543.Sfum_1337	1.21e-69	234.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_673011_1	754477.Q7C_2508	3.59e-36	139.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,45ZQ0@72273|Thiotrichales	72273|Thiotrichales	M	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
k59_1671653_1	765912.Thimo_0329	1.06e-141	414.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1WW6E@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
k59_1729083_1	255470.cbdbA108	5.64e-158	476.0	COG0553@1|root,COG0553@2|Bacteria,2G6I4@200795|Chloroflexi,34DJG@301297|Dehalococcoidia	301297|Dehalococcoidia	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
k59_980462_1	1304883.KI912532_gene930	2.94e-42	147.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,2KVA0@206389|Rhodocyclales	206389|Rhodocyclales	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_980462_2	1163408.UU9_13658	2.31e-39	132.0	COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,1S9MD@1236|Gammaproteobacteria,1X7KC@135614|Xanthomonadales	135614|Xanthomonadales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_980462_3	283942.IL2623	2.48e-21	88.2	COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,1S402@1236|Gammaproteobacteria,2QG3X@267893|Idiomarinaceae	1236|Gammaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031225,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	e_coli_core.b3736,iAF1260.b3736,iB21_1397.B21_03564,iBWG_1329.BWG_3427,iE2348C_1286.E2348C_4046,iEC042_1314.EC042_4123,iEC55989_1330.EC55989_4211,iECABU_c1320.ECABU_c42210,iECBD_1354.ECBD_4296,iECB_1328.ECB_03620,iECDH10B_1368.ECDH10B_3923,iECDH1ME8569_1439.ECDH1ME8569_3624,iECD_1391.ECD_03620,iECED1_1282.ECED1_4426,iECH74115_1262.ECH74115_5172,iECIAI1_1343.ECIAI1_3920,iECIAI39_1322.ECIAI39_4340,iECO103_1326.ECO103_4422,iECO111_1330.ECO111_4570,iECO26_1355.ECO26_4842,iECOK1_1307.ECOK1_4185,iECP_1309.ECP_3935,iECS88_1305.ECS88_4158,iECSE_1348.ECSE_4026,iECSF_1327.ECSF_3584,iECSP_1301.ECSP_4786,iECUMN_1333.ECUMN_4266,iECW_1372.ECW_m4039,iECs_1301.ECs4678,iEKO11_1354.EKO11_4609,iETEC_1333.ETEC_4027,iEcDH1_1363.EcDH1_4231,iEcE24377_1341.EcE24377A_4252,iEcHS_1320.EcHS_A3952,iEcSMS35_1347.EcSMS35_4104,iEcolC_1368.EcolC_4258,iG2583_1286.G2583_4532,iJO1366.b3736,iJR904.b3736,iSDY_1059.SDY_4012,iSFV_1184.SFV_3762,iSF_1195.SF3816,iSFxv_1172.SFxv_4159,iSSON_1240.SSON_3883,iS_1188.S3952,iSbBS512_1146.SbBS512_E4185,iUMN146_1321.UM146_18870,iUMNK88_1353.UMNK88_4548,iUTI89_1310.UTI89_C4291,iWFL_1372.ECW_m4039,iY75_1357.Y75_RS18390,iZ_1308.Z5234,ic_1306.c4664	ATP-synt_B
k59_203303_1	1304865.JAGF01000001_gene1847	8.5e-116	338.0	COG0852@1|root,COG0852@2|Bacteria,2GIRH@201174|Actinobacteria,4F0V6@85016|Cellulomonadaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_980463_1	1123261.AXDW01000002_gene1612	5.67e-57	191.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1X4B7@135614|Xanthomonadales	135614|Xanthomonadales	P	TrkA-N domain	-	-	-	-	-	-	-	-	-	-	-	-	TrkA_C,TrkA_N
k59_980463_2	1123518.ARWI01000001_gene1692	4.07e-14	72.4	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,45ZUX@72273|Thiotrichales	72273|Thiotrichales	L	DNA helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1201674_1	631362.Thi970DRAFT_01740	4.1e-30	107.0	2E323@1|root,32Y2B@2|Bacteria,1NDSQ@1224|Proteobacteria,1SI18@1236|Gammaproteobacteria,1X1AT@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1201674_2	768671.ThimaDRAFT_0661	7.34e-49	162.0	COG3900@1|root,COG3900@2|Bacteria,1NXBA@1224|Proteobacteria,1SZCY@1236|Gammaproteobacteria,1X2JW@135613|Chromatiales	135613|Chromatiales	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
k59_496454_1	269796.Rru_A2559	4.13e-51	182.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2TRJE@28211|Alphaproteobacteria,2JPPB@204441|Rhodospirillales	204441|Rhodospirillales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
k59_921364_1	96561.Dole_0339	2.14e-81	254.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,42MS9@68525|delta/epsilon subdivisions,2WJMS@28221|Deltaproteobacteria,2MI3S@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_1552573_1	460265.Mnod_6181	5.64e-15	78.6	COG4467@1|root,COG4467@2|Bacteria,1PPMF@1224|Proteobacteria,2U4GU@28211|Alphaproteobacteria,1JWE1@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Involved in initiation control of chromosome replication	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66
k59_1376626_2	1297570.MESS4_160077	2.91e-48	166.0	2CAAG@1|root,31SID@2|Bacteria,1N50D@1224|Proteobacteria,2UCSB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_275640_1	471853.Bcav_1749	1.44e-99	299.0	COG0484@1|root,COG0484@2|Bacteria,2GK69@201174|Actinobacteria	201174|Actinobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_921370_1	1047013.AQSP01000092_gene315	6.72e-103	327.0	COG3250@1|root,COG3250@2|Bacteria,2NQEM@2323|unclassified Bacteria	2|Bacteria	G	Glycosyl hydrolases family 2, TIM barrel domain	lacZ	GO:0003674,GO:0003824,GO:0004553,GO:0004565,GO:0005575,GO:0005975,GO:0005984,GO:0005988,GO:0005990,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009341,GO:0009987,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0032991,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0071704,GO:1901575,GO:1902494	3.2.1.23,3.2.1.31	ko:K01190,ko:K01195	ko00040,ko00052,ko00511,ko00531,ko00600,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00052,map00511,map00531,map00600,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01105,R01478,R01678,R03355,R04783,R04979,R06114,R07818,R08127,R08260,R10830	RC00049,RC00055,RC00171,RC00452,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_980480_1	1173024.KI912148_gene3740	1.14e-49	166.0	COG1136@1|root,COG1136@2|Bacteria,1G4IP@1117|Cyanobacteria	1117|Cyanobacteria	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_980480_2	1122604.JONR01000030_gene1337	1.4e-30	121.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria,1X36M@135614|Xanthomonadales	135614|Xanthomonadales	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_1500910_1	1123255.JHYS01000011_gene1269	7.42e-07	50.4	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2VQC3@28216|Betaproteobacteria,4ADGX@80864|Comamonadaceae	28216|Betaproteobacteria	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_1500910_2	1123401.JHYQ01000018_gene2356	9.93e-45	150.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria,460QK@72273|Thiotrichales	72273|Thiotrichales	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
k59_1020711_1	1120936.KB907214_gene4398	5.56e-43	150.0	COG1214@1|root,COG1214@2|Bacteria,2GMTM@201174|Actinobacteria,4EJ29@85012|Streptosporangiales	201174|Actinobacteria	O	Glycoprotease family	yeaZ	GO:0002949,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
k59_921384_1	706587.Desti_1056	5.16e-111	333.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,42MYA@68525|delta/epsilon subdivisions,2WKFB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Pyridoxal-dependent decarboxylase	-	-	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	EF-hand_7,Pyridoxal_deC
k59_1020713_1	190650.CC_3733	7.39e-61	199.0	COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,2TS9D@28211|Alphaproteobacteria,2KG1B@204458|Caulobacterales	204458|Caulobacterales	G	PFAM PfkB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
k59_1201695_1	1122201.AUAZ01000044_gene1315	3.51e-129	374.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,4655F@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG3344 Retron-type reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_1092318_2	857087.Metme_3579	2.24e-31	124.0	2CJMV@1|root,33YMR@2|Bacteria,1NZIJ@1224|Proteobacteria,1SQG4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	YfdX protein	-	-	-	-	-	-	-	-	-	-	-	-	YfdX
k59_437745_1	519989.ECTPHS_01589	2.34e-56	201.0	COG1807@1|root,COG1807@2|Bacteria,1RE4T@1224|Proteobacteria,1S5IF@1236|Gammaproteobacteria,1WYER@135613|Chromatiales	135613|Chromatiales	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_393017_2	443218.AS9A_2736	3.77e-28	111.0	COG3832@1|root,COG3832@2|Bacteria,2I8ND@201174|Actinobacteria,236RA@1762|Mycobacteriaceae	201174|Actinobacteria	S	Activator of Hsp90 ATPase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
k59_144773_1	1049564.TevJSym_ap00050	6.27e-115	356.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J57S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	cation transport ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
k59_1139304_1	1282361.ABAC402_15590	5.2e-05	46.6	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2TVD3@28211|Alphaproteobacteria,2KHC4@204458|Caulobacterales	204458|Caulobacterales	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
k59_555096_1	768671.ThimaDRAFT_4387	2.51e-57	198.0	COG3359@1|root,COG3359@2|Bacteria,1R5KG@1224|Proteobacteria,1RY3P@1236|Gammaproteobacteria,1WXHZ@135613|Chromatiales	135613|Chromatiales	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
k59_555096_2	748658.KB907314_gene9	4.9e-14	72.0	COG1205@1|root,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,1S0XD@1236|Gammaproteobacteria,1WXNC@135613|Chromatiales	135613|Chromatiales	L	DEAD DEAH box	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
k59_731618_1	317025.Tcr_0270	3.7e-27	103.0	2E445@1|root,32Z0E@2|Bacteria,1N7FY@1224|Proteobacteria,1SDJE@1236|Gammaproteobacteria,462W0@72273|Thiotrichales	72273|Thiotrichales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_731618_2	686340.Metal_2027	3.86e-55	177.0	COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,1SAHT@1236|Gammaproteobacteria,1XGEW@135618|Methylococcales	135618|Methylococcales	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_42548_1	1463879.JOHP01000025_gene4252	1.37e-13	77.0	COG1305@1|root,COG1305@2|Bacteria,2HQBB@201174|Actinobacteria	201174|Actinobacteria	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
k59_496497_1	547045.NEISICOT_00165	3.3e-31	110.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2VVTG@28216|Betaproteobacteria,2KRPH@206351|Neisseriales	206351|Neisseriales	K	Cold-shock DNA-binding domain protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_496497_2	631362.Thi970DRAFT_01985	2.84e-18	83.6	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1WVYY@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM isocitrate dehydrogenase, NADP-dependent	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,Iso_dh
k59_1332723_1	1500890.JQNL01000001_gene1707	3.79e-53	177.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1X4NB@135614|Xanthomonadales	135614|Xanthomonadales	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1610781_1	472759.Nhal_2070	1.73e-19	89.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1WWJI@135613|Chromatiales	135613|Chromatiales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_1610781_2	1565129.JSFF01000019_gene1633	5.94e-07	49.3	COG2905@1|root,COG2905@2|Bacteria,1MZGY@1224|Proteobacteria,1T3B6@1236|Gammaproteobacteria,2QEPE@267890|Shewanellaceae	1236|Gammaproteobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_1861021_1	1565129.JSFF01000015_gene11	6.4e-83	261.0	COG0069@1|root,COG3369@1|root,COG0069@2|Bacteria,COG3369@2|Bacteria,1MU7B@1224|Proteobacteria,1RP1C@1236|Gammaproteobacteria,2QA2N@267890|Shewanellaceae	1236|Gammaproteobacteria	E	Belongs to the glutamate synthase family	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Glu_synthase,Rieske,zf-CDGSH
k59_1552613_1	1120956.JHZK01000018_gene2382	1.28e-55	178.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2TRZ2@28211|Alphaproteobacteria,1JN3E@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_275712_1	455632.SGR_835	2.24e-63	206.0	COG3458@1|root,COG3458@2|Bacteria,2HY8W@201174|Actinobacteria,417ZN@629295|Streptomyces griseus group	2|Bacteria	Q	Acetyl xylan esterase (AXE1)	-	-	3.1.1.41	ko:K01060	ko00311,ko01130,map00311,map01130	-	R03062	RC00020,RC00041	ko00000,ko00001,ko01000	-	-	-	AXE1
k59_275712_2	1123278.KB893588_gene458	8.69e-30	112.0	COG4947@1|root,COG4947@2|Bacteria,4NI04@976|Bacteroidetes,47K69@768503|Cytophagia	976|Bacteroidetes	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_393058_1	1123514.KB905899_gene2028	3.04e-58	189.0	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,1SZRM@1236|Gammaproteobacteria,460HH@72273|Thiotrichales	72273|Thiotrichales	S	Molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
k59_1332754_1	349124.Hhal_1206	2.62e-11	66.6	COG3165@1|root,COG3165@2|Bacteria	2|Bacteria	S	ubiquinone biosynthetic process from chorismate	yigP	GO:0006082,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0019752,GO:0032150,GO:0042180,GO:0042181,GO:0043436,GO:0043648,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046417,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	-	ko:K03690	-	-	-	-	ko00000	-	-	-	SCP2
k59_99579_2	1283283.ATXA01000009_gene3338	4.27e-07	53.5	COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria,4ERRB@85013|Frankiales	201174|Actinobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	vdh	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.4.1.23,1.4.1.9	ko:K00263,ko:K00271	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01212,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_496519_1	640511.BC1002_1839	8.27e-54	188.0	COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,2VH6A@28216|Betaproteobacteria,1K0R2@119060|Burkholderiaceae	28216|Betaproteobacteria	K	SMART Resolvase, RNase H domain protein fold	tex	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
k59_100136_1	1458275.AZ34_10625	9.92e-65	213.0	COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,1MV37@1224|Proteobacteria,2VJ21@28216|Betaproteobacteria,4AABZ@80864|Comamonadaceae	28216|Betaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD,HD_5
k59_1786861_1	314285.KT71_13475	8.64e-13	64.3	2DSZX@1|root,33I3R@2|Bacteria,1NNRD@1224|Proteobacteria,1SVBW@1236|Gammaproteobacteria,1JBPC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1092768_1	1000565.METUNv1_02702	5.74e-79	260.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KVA4@206389|Rhodocyclales	206389|Rhodocyclales	U	efflux pump	-	-	-	ko:K18138,ko:K18146	ko01501,ko01503,map01501,map01503	M00647,M00649,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.40	-	-	ACR_tran
k59_673437_1	1297742.A176_01794	1.77e-17	78.2	2DTBN@1|root,33JKH@2|Bacteria,1NNEI@1224|Proteobacteria,43B0P@68525|delta/epsilon subdivisions,2X6ER@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	-
k59_731999_1	235985.BBPN01000006_gene3497	1.77e-64	207.0	COG0412@1|root,COG0412@2|Bacteria,2GK7H@201174|Actinobacteria,2NM33@228398|Streptacidiphilus	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
k59_1501385_1	2340.JV46_03780	9.43e-162	474.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1J4GN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_1437166_2	62977.ACIAD3267	1.17e-09	66.6	COG3509@1|root,COG3509@2|Bacteria,1N6M6@1224|Proteobacteria,1S6C7@1236|Gammaproteobacteria,3NN2H@468|Moraxellaceae	1236|Gammaproteobacteria	Q	Esterase PHB depolymerase	lpqC	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Abhydrolase_2,Esterase_phd
k59_100155_1	1198232.CYCME_2167	1.51e-34	123.0	COG0810@1|root,COG0810@2|Bacteria,1RKRA@1224|Proteobacteria	1224|Proteobacteria	M	Cell envelope biogenesis protein TolA	tolA	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	TonB_2
k59_100155_2	1283300.ATXB01000002_gene3020	1.38e-05	47.4	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1XEH5@135618|Methylococcales	135618|Methylococcales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_555493_1	1121918.ARWE01000001_gene9	7.57e-31	113.0	arCOG08935@1|root,32Z08@2|Bacteria,1NC5T@1224|Proteobacteria,42XQ1@68525|delta/epsilon subdivisions,2X6PR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1611144_1	1117318.PRUB_15850	2.49e-28	103.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,2Q3JP@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	K	Cold shock protein domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_151668_1	338963.Pcar_1390	1.41e-47	165.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,42MBN@68525|delta/epsilon subdivisions,2WINT@28221|Deltaproteobacteria,43T6E@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_991259_2	998088.B565_0264	1.27e-10	63.5	COG1714@1|root,COG1714@2|Bacteria,1N4N8@1224|Proteobacteria,1S9C5@1236|Gammaproteobacteria,1Y4RK@135624|Aeromonadales	135624|Aeromonadales	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
k59_991259_3	519989.ECTPHS_04940	7.8e-27	109.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,1WWXY@135613|Chromatiales	135613|Chromatiales	S	Permease YjgP YjgQ	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_403660_1	1123371.ATXH01000022_gene982	9.27e-108	326.0	COG0107@1|root,COG0118@1|root,COG0107@2|Bacteria,COG0118@2|Bacteria,2GGYN@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K01663,ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase,His_biosynth
k59_738533_1	880072.Desac_1429	6.27e-70	216.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,42M5X@68525|delta/epsilon subdivisions,2WJGN@28221|Deltaproteobacteria,2MRHQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_503030_1	314607.KB13_1097	8.2e-25	98.2	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2VRPJ@28216|Betaproteobacteria,1KQRJ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
k59_503030_2	1137799.GZ78_21380	8.47e-45	154.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,1RMYQ@1236|Gammaproteobacteria,1XJ78@135619|Oceanospirillales	135619|Oceanospirillales	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
k59_403664_1	1298593.TOL_1615	1.66e-71	228.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,1XHH6@135619|Oceanospirillales	135619|Oceanospirillales	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroF-1	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
k59_444402_1	177437.HRM2_34570	4.62e-65	211.0	COG0477@1|root,COG2814@2|Bacteria,1R9V9@1224|Proteobacteria,42Q1C@68525|delta/epsilon subdivisions,2WK7P@28221|Deltaproteobacteria,2MMQA@213118|Desulfobacterales	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
k59_1099557_1	1158292.JPOE01000002_gene3590	7.27e-71	231.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,1KJ21@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3
k59_620270_1	1033802.SSPSH_002047	3.68e-46	159.0	COG1073@1|root,COG1073@2|Bacteria,1MUCD@1224|Proteobacteria,1RP4I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Hydrolases of the alpha beta superfamily	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,DLH,Hydrolase_4
k59_110154_1	553217.ENHAE0001_0892	1.77e-69	221.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,3NK7D@468|Moraxellaceae	1236|Gammaproteobacteria	I	Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed	fadA	GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_2612,iECNA114_1301.ECNA114_4154,iECOK1_1307.ECOK1_4314,iECP_1309.ECP_4058,iECS88_1305.ECS88_4293,iECSF_1327.ECSF_3702,iEcE24377_1341.EcE24377A_4364,iLF82_1304.LF82_0613,iNRG857_1313.NRG857_19195,iPC815.YPO3767	Thiolase_C,Thiolase_N
k59_110154_2	1217715.F994_00437	7.67e-21	90.9	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,3NIPR@468|Moraxellaceae	1236|Gammaproteobacteria	I	Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate	fadB	GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8	ko:K01782,ko:K01825	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	iLF82_1304.LF82_0614,iNRG857_1313.NRG857_19200	3HCDH,3HCDH_N,ECH_1
k59_991279_1	1121271.AUCM01000002_gene3962	5.5e-55	186.0	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2TQS7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	gor	GO:0000166,GO:0000302,GO:0000305,GO:0003674,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0017076,GO:0019725,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0065008,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901700	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_932095_1	472759.Nhal_0580	1.25e-59	195.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1WWHU@135613|Chromatiales	135613|Chromatiales	C	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_932095_2	1056820.KB900655_gene3638	8.45e-28	111.0	COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,1RNTZ@1236|Gammaproteobacteria,2PMUD@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	O	Anhydro-N-acetylmuramic acid kinase	anmK	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	iECABU_c1320.ECABU_c18930,iECED1_1282.ECED1_1841,ic_1306.c2032	AnmK
k59_1872738_1	1121405.dsmv_1132	7.9e-78	245.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P8Q@68525|delta/epsilon subdivisions,2WK2B@28221|Deltaproteobacteria,2MMPV@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Sigma-54 interaction domain	-	-	-	ko:K11384	ko02020,map02020	M00505	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1274833_1	34506.g1400	6.47e-41	154.0	COG0183@1|root,COG1024@1|root,KOG1392@2759|Eukaryota,KOG1683@2759|Eukaryota,38CY9@33154|Opisthokonta,3BE3Y@33208|Metazoa,3CXNY@33213|Bilateria,40AGF@6231|Nematoda,1KXXJ@119089|Chromadorea,40UFS@6236|Rhabditida	33208|Metazoa	I	enoyl-CoA hydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N,ECH_1,Thiolase_C,Thiolase_N
k59_1679050_1	930169.B5T_00214	4.28e-98	306.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1XIVW@135619|Oceanospirillales	135619|Oceanospirillales	EQ	N-methylhydantoinase A acetone carboxylase, beta subunit	hyuA	-	3.5.2.14,3.5.2.9	ko:K01469,ko:K01473	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00251,R03187	RC00553,RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_1145716_1	713587.THITH_05400	1.44e-75	248.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,1WWFC@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.18.1.1,1.7.1.15	ko:K00362,ko:K05297	ko00071,ko00910,ko01120,map00071,map00910,map01120	M00530	R00787,R02000	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
k59_1444055_2	610130.Closa_1471	0.000475	42.7	COG2188@1|root,COG2188@2|Bacteria,1UYBW@1239|Firmicutes,24N1N@186801|Clostridia,220Q2@1506553|Lachnoclostridium	186801|Clostridia	K	UbiC transcription regulator-associated domain protein	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
k59_680645_1	425104.Ssed_1770	1.46e-48	170.0	COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,1S6AN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KT	phosphohydrolase	rela3	-	-	-	-	-	-	-	-	-	-	-	HD_4
k59_1618300_1	1049564.TevJSym_bk00240	3.1e-65	209.0	COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,1RRWT@1236|Gammaproteobacteria,1JAVX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_992312_1	706587.Desti_0740	2.7e-25	103.0	COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,42MEY@68525|delta/epsilon subdivisions,2WM0F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
k59_992312_2	292415.Tbd_1584	6.5e-51	168.0	COG1073@1|root,COG1073@2|Bacteria,1RDAY@1224|Proteobacteria,2VQGW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	phosphoribosyltransferase	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH
k59_1208848_1	1163617.SCD_n01285	1.17e-130	400.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria	28216|Betaproteobacteria	E	PFAM transglutaminase domain protein	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
k59_1618302_1	485913.Krac_3007	2.91e-34	133.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
k59_1736409_1	395493.BegalDRAFT_0212	6.19e-153	441.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,460AT@72273|Thiotrichales	72273|Thiotrichales	C	Belongs to the heme-copper respiratory oxidase family	-	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_1736409_2	566466.NOR53_737	2.97e-38	135.0	28H8Z@1|root,2Z7KS@2|Bacteria,1MW9T@1224|Proteobacteria,1RQV1@1236|Gammaproteobacteria,1J6DS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1282
k59_1679056_1	530564.Psta_3337	3.64e-37	147.0	COG0515@1|root,COG0515@2|Bacteria,2J50A@203682|Planctomycetes	203682|Planctomycetes	KLT	PFAM Serine threonine protein kinase-related	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,dCache_1
k59_1100324_1	768671.ThimaDRAFT_4037	1.31e-179	514.0	COG3385@1|root,COG3385@2|Bacteria,1RA6A@1224|Proteobacteria,1SDJ1@1236|Gammaproteobacteria,1X0RY@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1344573_1	573370.DMR_33550	6.69e-67	219.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,42MGF@68525|delta/epsilon subdivisions,2WJMB@28221|Deltaproteobacteria,2M9H9@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM Carboxylyase-related protein	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_152413_1	1283287.KB822576_gene3927	6.16e-45	152.0	COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria,4DPWD@85009|Propionibacteriales	201174|Actinobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
k59_856125_1	697282.Mettu_3556	7.89e-54	182.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RMKV@1236|Gammaproteobacteria,1XE0I@135618|Methylococcales	135618|Methylococcales	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_856125_2	675812.VHA_000122	4.49e-06	48.5	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1XU4M@135623|Vibrionales	135623|Vibrionales	P	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA	trkH	GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031224,GO:0031226,GO:0031420,GO:0034220,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046983,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_1274868_1	644283.Micau_0207	4.98e-15	76.3	COG1595@1|root,COG1595@2|Bacteria,2IPF0@201174|Actinobacteria,4DJ7T@85008|Micromonosporales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_210846_1	156889.Mmc1_0519	2.38e-61	206.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TS80@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1509209_1	1713.JOFV01000001_gene1977	4.67e-85	265.0	COG0215@1|root,COG0215@2|Bacteria,2GJF2@201174|Actinobacteria,4F0ES@85016|Cellulomonadaceae	201174|Actinobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
k59_1618335_1	1116472.MGMO_118c00080	4.09e-31	125.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RR5W@1236|Gammaproteobacteria,1XE73@135618|Methylococcales	135618|Methylococcales	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_9
k59_111266_1	1043205.AFYF01000075_gene2116	3.47e-17	79.0	COG2065@1|root,COG2065@2|Bacteria,2GJNP@201174|Actinobacteria,4FFMC@85021|Intrasporangiaceae	201174|Actinobacteria	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
k59_445169_1	1126627.BAWE01000005_gene6111	1.02e-26	127.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_1145756_1	582744.Msip34_1393	0.000394	42.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,2VKZP@28216|Betaproteobacteria,2KKYX@206350|Nitrosomonadales	206350|Nitrosomonadales	CI	TIGRFAM oxaloacetate decarboxylase alpha subunit	-	-	6.4.1.1	ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_1145756_2	713587.THITH_07655	2.11e-76	234.0	COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,1S3TQ@1236|Gammaproteobacteria,1WX51@135613|Chromatiales	135613|Chromatiales	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_562371_1	880072.Desac_1209	6.55e-147	427.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria,2MRBS@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_111275_1	1304275.C41B8_03042	2.17e-24	103.0	COG2503@1|root,COG2503@2|Bacteria,1R9UX@1224|Proteobacteria,1S2CZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Acid phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Acid_phosphat_B
k59_1618346_1	1117647.M5M_04620	2.01e-34	128.0	COG1196@1|root,COG1196@2|Bacteria,1R4BS@1224|Proteobacteria,1S13B@1236|Gammaproteobacteria,1J7UD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	von Willebrand factor (VWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_1618346_2	876044.IMCC3088_857	6.5e-23	98.2	COG2304@1|root,COG2304@2|Bacteria,1QBPM@1224|Proteobacteria,1RQIU@1236|Gammaproteobacteria,1J4PZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Secreted protein, containing von Willebrand factor (VWF) type	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1736458_1	1307761.L21SP2_2452	1.05e-21	90.9	COG0500@1|root,COG2226@2|Bacteria,2J6Y1@203691|Spirochaetes	203691|Spirochaetes	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
k59_1736458_2	927658.AJUM01000034_gene76	3.25e-33	125.0	COG5000@1|root,COG5000@2|Bacteria,4NEWF@976|Bacteroidetes,2FP7E@200643|Bacteroidia,3XIUP@558415|Marinilabiliaceae	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_1444111_1	28042.GU90_06530	1.98e-28	111.0	COG0601@1|root,COG0601@2|Bacteria,2GM72@201174|Actinobacteria,4DZ95@85010|Pseudonocardiales	201174|Actinobacteria	P	ABC-type dipeptide oligopeptide nickel transport	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1444111_2	1449976.KALB_4321	1.79e-14	74.7	COG1173@1|root,COG1173@2|Bacteria,2GKAW@201174|Actinobacteria,4DYSP@85010|Pseudonocardiales	201174|Actinobacteria	EP	ABC-type dipeptide oligopeptide nickel transport system, permease component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_856157_1	1121935.AQXX01000144_gene4308	9.74e-49	177.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyltransferase,Aminotran_1_2,NAD_binding_4,PP-binding,Thioesterase
k59_503817_1	768671.ThimaDRAFT_3040	1.53e-81	246.0	COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,1S6WA@1236|Gammaproteobacteria,1WXPI@135613|Chromatiales	135613|Chromatiales	F	phosphoribosyltransferase	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
k59_503817_2	765912.Thimo_2554	1.36e-59	187.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria,1WYAH@135613|Chromatiales	135613|Chromatiales	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
k59_503817_3	1049564.TevJSym_bn00100	2.28e-23	93.6	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1J62V@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	yqgE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_1026905_1	367299.JOEE01000012_gene3276	5.3e-101	296.0	COG1309@1|root,COG1309@2|Bacteria,2GVM5@201174|Actinobacteria,4FFZW@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1026905_2	367299.JOEE01000012_gene3277	5.35e-23	96.3	COG0476@1|root,COG0476@2|Bacteria,2GJB6@201174|Actinobacteria,4FF9A@85021|Intrasporangiaceae	201174|Actinobacteria	H	The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are	moeB	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
k59_992404_1	1038860.AXAP01000031_gene5725	1.83e-83	270.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,3JR79@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,HlyD_D23,Hydrolase,Hydrolase_3
k59_1872872_1	85643.Tmz1t_1784	8.89e-22	89.7	COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,2VSJY@28216|Betaproteobacteria,2KWJA@206389|Rhodocyclales	206389|Rhodocyclales	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
k59_1872872_2	1123256.KB907937_gene1872	2.42e-40	148.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1X3CI@135614|Xanthomonadales	135614|Xanthomonadales	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
k59_562393_1	330214.NIDE0016	1.43e-54	178.0	COG2514@1|root,COG2514@2|Bacteria	2|Bacteria	S	catechol 2,3-dioxygenase activity	-	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
k59_621079_1	1051632.TPY_3609	1.23e-30	124.0	COG1022@1|root,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,25E9H@186801|Clostridia,3WD2E@538999|Clostridiales incertae sedis	186801|Clostridia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_152479_1	1500259.JQLD01000010_gene4801	2.41e-21	93.2	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,4BC3N@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
k59_152479_2	1429916.X566_04240	7.04e-72	219.0	COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria,2TQQ2@28211|Alphaproteobacteria,3JXUB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
k59_1384378_1	880072.Desac_2497	2.7e-34	123.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,42M39@68525|delta/epsilon subdivisions,2WJEZ@28221|Deltaproteobacteria,2MQ53@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
k59_1384378_2	338966.Ppro_1768	7.25e-45	152.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,42QQ4@68525|delta/epsilon subdivisions,2WQGH@28221|Deltaproteobacteria,43UAM@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_404848_1	367299.JOEE01000001_gene1514	3.53e-15	73.2	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,4FJ3J@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_404848_2	367299.JOEE01000001_gene1513	2.69e-143	415.0	COG1744@1|root,COG1744@2|Bacteria,2GMFS@201174|Actinobacteria,4FG7H@85021|Intrasporangiaceae	201174|Actinobacteria	S	ABC transporter substrate-binding protein PnrA-like	bmpA	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
k59_285781_1	1449126.JQKL01000035_gene2155	1.91e-43	161.0	COG0068@1|root,COG0068@2|Bacteria,1TQM7@1239|Firmicutes,2494A@186801|Clostridia	186801|Clostridia	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_1384381_1	1049564.TevJSym_ar00380	3.58e-65	211.0	COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1QYEW@1224|Proteobacteria,1T3PI@1236|Gammaproteobacteria,1JAK0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Pyr_redox_3
k59_503842_1	765910.MARPU_13475	1.44e-38	143.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,1WXMF@135613|Chromatiales	135613|Chromatiales	O	PFAM Thioredoxin	-	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_791948_1	1278073.MYSTI_05584	1.3e-88	278.0	COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,42ZIG@68525|delta/epsilon subdivisions,2WUZE@28221|Deltaproteobacteria,2YX8Y@29|Myxococcales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_1026922_1	519989.ECTPHS_07491	8.6e-66	209.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,1WY8N@135613|Chromatiales	135613|Chromatiales	KT	Response regulator of the LytR AlgR family	-	-	-	ko:K08083	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
k59_52989_1	637390.AFOH01000056_gene1559	3.52e-123	365.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,2NCE4@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_52989_2	999141.GME_01544	5.41e-11	62.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1XJ47@135619|Oceanospirillales	135619|Oceanospirillales	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
k59_1274962_1	933262.AXAM01000029_gene2752	6.2e-94	290.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MAV@68525|delta/epsilon subdivisions,2WJC9@28221|Deltaproteobacteria,2MIPJ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	cimA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_992449_1	110319.CF8_4201	2.55e-76	239.0	COG2801@1|root,COG2801@2|Bacteria,2IEHA@201174|Actinobacteria	201174|Actinobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	rve,rve_3
k59_210909_1	1249627.D779_1673	3.6e-66	210.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,1WXSE@135613|Chromatiales	135613|Chromatiales	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	-	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
k59_1793042_1	1123054.KB907711_gene413	4.43e-42	146.0	COG3326@1|root,COG3326@2|Bacteria,1N6YM@1224|Proteobacteria,1SCMX@1236|Gammaproteobacteria,1WZHU@135613|Chromatiales	135613|Chromatiales	K	Cold-shock protein, DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	CSD,DUF1294
k59_621096_1	1168065.DOK_04347	3.83e-69	223.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1J53P@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Ammonium Transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_621096_3	765913.ThidrDRAFT_0181	2.32e-09	57.4	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1WWG6@135613|Chromatiales	135613|Chromatiales	P	Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_452005_1	110319.CF8_2797	4.23e-44	157.0	COG1063@1|root,COG1063@2|Bacteria,2H3Y2@201174|Actinobacteria	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	-	ko:K19956	ko00051,map00051	-	R03234	RC00089	ko00000,ko00001,ko01000	-	-	-	ADH_N
k59_1107947_1	390235.PputW619_3487	9.98e-66	215.0	COG0628@1|root,COG0628@2|Bacteria,1R5W4@1224|Proteobacteria,1SZYZ@1236|Gammaproteobacteria,1YVQU@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_569181_1	1335757.SPICUR_02460	4.08e-45	158.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1WW48@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_1685817_1	1304865.JAGF01000001_gene664	1.17e-113	343.0	COG3428@1|root,COG3428@2|Bacteria,2GJCD@201174|Actinobacteria,4F13S@85016|Cellulomonadaceae	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
k59_452013_1	1121920.AUAU01000021_gene2516	4.69e-11	60.1	COG0827@1|root,COG0827@2|Bacteria	2|Bacteria	L	DNA restriction-modification system	hsdBM	-	2.1.1.72	ko:K07317	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	BsuBI_PstI_RE,Eco57I,N6_Mtase,PCMT,RrnaAD
k59_452013_2	369723.Strop_0105	1.49e-52	174.0	COG0827@1|root,COG0827@2|Bacteria,2IA07@201174|Actinobacteria	201174|Actinobacteria	L	restriction endonuclease domain protein	-	-	3.1.21.4	ko:K01155	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	BsuBI_PstI_RE
k59_1516544_1	880072.Desac_2500	9.4e-93	283.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2WJQQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.18,1.2.1.20,1.2.1.27,1.2.1.3,1.2.1.79,1.2.1.9	ko:K00128,ko:K00131,ko:K00135,ko:K00140	ko00010,ko00030,ko00053,ko00071,ko00250,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00562,ko00620,ko00625,ko00640,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00562,map00620,map00625,map00640,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130,map01200	M00013,M00027,M00135,M00308,M00633	R00264,R00631,R00705,R00706,R00710,R00713,R00714,R00904,R00922,R00935,R01058,R01752,R01986,R02401,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00004,RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_510723_1	953739.SVEN_6756	7.64e-20	93.6	COG3118@1|root,COG3118@2|Bacteria,2I35R@201174|Actinobacteria	201174|Actinobacteria	O	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotran_2,Arylsulfotrans
k59_217300_1	1101195.Meth11DRAFT_1700	6.48e-106	325.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,2KKKI@206350|Nitrosomonadales	206350|Nitrosomonadales	CP	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_1390692_1	710696.Intca_1139	5.31e-14	72.0	COG4584@1|root,COG4584@2|Bacteria,2GM4J@201174|Actinobacteria,4FFND@85021|Intrasporangiaceae	201174|Actinobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1624693_1	1124983.PFLCHA0_c44900	6.86e-22	99.4	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,1RQZJ@1236|Gammaproteobacteria,1YM9I@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	I	OMPP1 FadL TodX family	fadL	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_510736_1	1267005.KB911256_gene1467	6.57e-119	360.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,3N7YM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Methylmalonyl-CoA mutase	mutB	-	5.4.99.63	ko:K14447	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09292	RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
k59_159098_1	648757.Rvan_0598	1.88e-72	219.0	COG1553@1|root,COG1553@2|Bacteria,1N021@1224|Proteobacteria,2UA3H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	DsrE/DsrF-like family	-	-	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
k59_1215574_1	648757.Rvan_2522	4.47e-112	352.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3N7VF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	Protein export membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1215578_1	452637.Oter_2424	7.48e-43	159.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,46VB0@74201|Verrucomicrobia,3K8AK@414999|Opitutae	414999|Opitutae	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_797234_1	1218074.BAXZ01000004_gene1207	2.56e-74	237.0	COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,2VJ1V@28216|Betaproteobacteria,1K0UD@119060|Burkholderiaceae	28216|Betaproteobacteria	C	nitrate reductase beta subunit	narH	-	1.7.5.1	ko:K00371,ko:K17051	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8	-	-	Fer4_11,Nitr_red_bet_C
k59_1685876_1	502025.Hoch_3261	6.08e-44	163.0	COG2304@1|root,COG2304@2|Bacteria,1PYZT@1224|Proteobacteria,435MP@68525|delta/epsilon subdivisions,2XA2Q@28221|Deltaproteobacteria,2YYF8@29|Myxococcales	28221|Deltaproteobacteria	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
k59_1516604_1	391615.ABSJ01000050_gene1235	5.76e-47	152.0	COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,1S4YE@1236|Gammaproteobacteria,1J6FI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	PilZ domain	pilZ	-	-	ko:K02676	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilZ
k59_1516604_2	396588.Tgr7_1826	1.14e-23	97.1	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,1RP6E@1236|Gammaproteobacteria,1WXA1@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM hydrolase, TatD family	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
k59_335326_1	1380355.JNIJ01000041_gene5229	5.8e-27	110.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria,3JUGA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
k59_335326_2	1267005.KB911261_gene2309	8.88e-132	385.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,2TS31@28211|Alphaproteobacteria,3N9FI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	aceF	-	2.3.1.12,2.3.1.168	ko:K00627,ko:K09699	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200	M00036,M00307	R00209,R02569,R02662,R03174,R04097,R10998	RC00004,RC02727,RC02742,RC02857,RC02870	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_569241_1	1121396.KB893072_gene1256	5.4e-06	46.2	COG2963@1|root,COG2963@2|Bacteria,1MZ5C@1224|Proteobacteria,42WWI@68525|delta/epsilon subdivisions,2WSR8@28221|Deltaproteobacteria,2MM98@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_569241_2	580332.Slit_2788	6.59e-20	90.1	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VQF1@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_1390732_1	335543.Sfum_0821	1.19e-82	273.0	COG1148@1|root,COG2204@1|root,COG1148@2|Bacteria,COG2204@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FAD_oxidored,Fer4,Fer4_7,NAD_binding_8,Pyr_redox_2,Response_reg
k59_569242_1	335543.Sfum_0552	2.3e-65	212.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2WKTU@28221|Deltaproteobacteria,2MQRV@213462|Syntrophobacterales	28221|Deltaproteobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1034958_1	702113.PP1Y_Mpl8121	1.52e-05	52.8	COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2UPIE@28211|Alphaproteobacteria,2K8HT@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_159140_1	1089552.KI911559_gene3257	1.28e-12	72.0	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,2TRUD@28211|Alphaproteobacteria,2JS06@204441|Rhodospirillales	204441|Rhodospirillales	S	Predicted integral membrane protein (DUF2189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2189
k59_862884_1	472759.Nhal_1065	3.29e-78	255.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1WWDE@135613|Chromatiales	135613|Chromatiales	T	Belongs to the PEP-utilizing enzyme family	-	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_1798886_1	1265313.HRUBRA_01483	3.33e-64	209.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,1J4SM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Permease	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_217358_1	999141.GME_17487	2.74e-13	65.1	COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,1SD35@1236|Gammaproteobacteria,1XKMB@135619|Oceanospirillales	135619|Oceanospirillales	K	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters	fis	-	-	ko:K03557	ko05111,map05111	-	-	-	ko00000,ko00001,ko03000,ko03036,ko03400	-	-	-	HTH_8
k59_217358_2	1121013.P873_12175	1.47e-77	247.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1X3IH@135614|Xanthomonadales	135614|Xanthomonadales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_1215636_1	1249627.D779_3202	4.17e-48	155.0	2E0T4@1|root,32WAV@2|Bacteria,1N19Z@1224|Proteobacteria,1SBDA@1236|Gammaproteobacteria,1WZ0Q@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_862895_1	935845.JADQ01000015_gene3282	2.9e-17	86.3	COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,4H9SP@91061|Bacilli,26VW3@186822|Paenibacillaceae	91061|Bacilli	P	E1-E2 ATPase	cadA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
k59_1566544_1	1141663.OOC_11941	2.97e-22	102.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,3Z7GV@586|Providencia	1236|Gammaproteobacteria	P	Sulfate permease	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
k59_1743687_1	1035191.HMPREF0185_02813	5.88e-127	367.0	COG2801@1|root,COG2801@2|Bacteria,1PFGA@1224|Proteobacteria,2V977@28211|Alphaproteobacteria,2KJ5N@204458|Caulobacterales	204458|Caulobacterales	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_797270_1	1348657.M622_00470	1.02e-78	243.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria,2KU8B@206389|Rhodocyclales	206389|Rhodocyclales	M	mechanosensitive	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_159156_1	312284.A20C1_01611	4.2e-47	167.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_1624752_1	395493.BegalDRAFT_2442	2.09e-15	79.7	COG3297@1|root,COG3297@2|Bacteria,1NVVW@1224|Proteobacteria,1S01F@1236|Gammaproteobacteria,462ER@72273|Thiotrichales	72273|Thiotrichales	U	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins	-	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspL_C,T2SSL
k59_510799_1	1304275.C41B8_18351	1.2e-06	50.4	COG3017@1|root,COG3017@2|Bacteria,1N02T@1224|Proteobacteria,1S91E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein	lolB	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0010876,GO:0016020,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0034613,GO:0042157,GO:0042277,GO:0043170,GO:0044238,GO:0044462,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0051668,GO:0070727,GO:0071704,GO:0071723,GO:0071944,GO:0072657,GO:1901564	-	ko:K02494	-	-	-	-	ko00000	-	-	-	LolB
k59_510799_2	1163407.UU7_07353	1.7e-39	144.0	COG0454@1|root,COG1947@1|root,COG0454@2|Bacteria,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria,1X30B@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,GHMP_kinases_C,GHMP_kinases_N
k59_687376_2	379066.GAU_1924	3.83e-20	92.4	COG2805@1|root,COG2805@2|Bacteria,1ZU8X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_1566556_2	1049564.TevJSym_ao00740	3.28e-24	99.4	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,1J4IH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Cell shape-determining protein	mreC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0043621,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944,GO:0071963	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
k59_1390766_1	880072.Desac_0856	2.13e-60	192.0	COG1387@1|root,COG1387@2|Bacteria,1R9W5@1224|Proteobacteria,42QNF@68525|delta/epsilon subdivisions,2WMV0@28221|Deltaproteobacteria,2MRJE@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	DNA polymerase alpha chain like domain	-	-	-	-	-	-	-	-	-	-	-	-	PHP
k59_1390766_2	1121405.dsmv_1043	8.5e-17	77.0	COG1259@1|root,COG1259@2|Bacteria,1RFFV@1224|Proteobacteria,42SCI@68525|delta/epsilon subdivisions,2WPWT@28221|Deltaproteobacteria,2MJT1@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
k59_1151815_1	535289.Dtpsy_2595	3.55e-24	99.0	COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,2VRHV@28216|Betaproteobacteria,4AEAE@80864|Comamonadaceae	28216|Betaproteobacteria	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
k59_1151815_2	1151116.Q7S_17885	6.12e-17	76.6	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,1S9AB@1236|Gammaproteobacteria,3FHIF@34037|Rahnella	1236|Gammaproteobacteria	S	Belongs to the UPF0235 family	yggU	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
k59_1798905_1	323261.Noc_2266	4.91e-10	63.5	2DQ0C@1|root,33473@2|Bacteria,1NAM4@1224|Proteobacteria,1SCY6@1236|Gammaproteobacteria,1X1YC@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1798905_2	1304275.C41B8_11513	7.59e-13	75.9	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Protein involved in outer membrane biogenesis	asmA	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA
k59_1685933_1	1198232.CYCME_0076	6.37e-18	84.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,45ZU9@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
k59_1685933_2	545276.KB898734_gene2349	7.41e-43	147.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,1RNPM@1236|Gammaproteobacteria,1WWUW@135613|Chromatiales	135613|Chromatiales	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
k59_1516670_1	867845.KI911784_gene3678	4.5e-16	78.2	COG0653@1|root,COG0653@2|Bacteria,2G603@200795|Chloroflexi,374YG@32061|Chloroflexia	32061|Chloroflexia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1516670_2	391615.ABSJ01000032_gene731	6.42e-57	186.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,1JAGN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_687387_1	1033802.SSPSH_003315	7.16e-67	221.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,1RMFH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate	cysI	GO:0003674,GO:0003824,GO:0004783,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006790,GO:0008150,GO:0008152,GO:0009337,GO:0009987,GO:0016002,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016673,GO:0019419,GO:0020037,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0046906,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0097159,GO:1901363	1.8.1.2	ko:K00381	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_3037,iECH74115_1262.ECH74115_4017,iECIAI1_1343.ECIAI1_2867,iECNA114_1301.ECNA114_2794,iECO103_1326.ECO103_3307,iECSE_1348.ECSE_3019,iECSF_1327.ECSF_2552,iECSP_1301.ECSP_3712,iECUMN_1333.ECUMN_3091,iECW_1372.ECW_m2971,iECs_1301.ECs3618,iEKO11_1354.EKO11_1005,iEcE24377_1341.EcE24377A_3065,iSFV_1184.SFV_2742,iSbBS512_1146.SbBS512_E3112,iWFL_1372.ECW_m2971,iZ_1308.Z4073	NIR_SIR,NIR_SIR_ferr
k59_1685935_3	593750.Metfor_2329	1.27e-06	50.4	arCOG02590@1|root,arCOG07605@1|root,arCOG02590@2157|Archaea,arCOG07605@2157|Archaea	2157|Archaea	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
k59_1151824_1	593907.Celgi_2265	1.66e-69	241.0	COG1074@1|root,COG1074@2|Bacteria,2GNKH@201174|Actinobacteria	201174|Actinobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1516682_1	1353537.TP2_00590	2.13e-71	237.0	COG0845@1|root,COG0845@2|Bacteria,1N97Q@1224|Proteobacteria,2U22Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	GAF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,GAF,HlyD_3,HlyD_D23
k59_452126_1	519989.ECTPHS_07242	6.82e-84	264.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales	135613|Chromatiales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_1517865_1	305700.B447_04212	9.96e-70	221.0	COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,2VQQD@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_511670_1	1440053.JOEI01000040_gene6761	0.000261	49.3	COG0515@1|root,COG0515@2|Bacteria,2I9TC@201174|Actinobacteria	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_1686881_1	557598.LHK_00549	0.000634	46.2	COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,2VK79@28216|Betaproteobacteria,2KQQD@206351|Neisseriales	206351|Neisseriales	T	diguanylate cyclase	-	-	2.7.7.65	ko:K13590	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF
k59_1216631_1	1077972.ARGLB_094_00160	1e-117	354.0	COG3064@1|root,COG3271@1|root,COG3064@2|Bacteria,COG3271@2|Bacteria,2H973@201174|Actinobacteria	201174|Actinobacteria	M	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I36,Transglycosylas,VCBS
k59_1035973_2	582899.Hden_2534	4.97e-23	96.7	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2TT2F@28211|Alphaproteobacteria,3N7SR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	nemA	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_570121_1	396588.Tgr7_0231	6.16e-62	194.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,1WY8U@135613|Chromatiales	135613|Chromatiales	U	general secretion pathway protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
k59_1283720_2	1540221.JQNI01000002_gene2560	8.32e-15	69.7	COG0251@1|root,COG0251@2|Bacteria,1WK0P@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
k59_1517885_1	1122137.AQXF01000004_gene1696	3.69e-47	167.0	COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,2UFKH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
k59_1216640_1	523791.Kkor_0315	1.91e-58	193.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1XHQS@135619|Oceanospirillales	135619|Oceanospirillales	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_511679_1	983545.Glaag_3597	4.43e-49	183.0	COG0784@1|root,COG2202@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,46D3N@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_9,Response_reg
k59_1567504_1	1121013.P873_05875	5.58e-121	365.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,1X39Z@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_1744664_1	1265505.ATUG01000001_gene4652	3.37e-22	102.0	COG3852@1|root,COG4564@1|root,COG3852@2|Bacteria,COG4564@2|Bacteria,1NTTH@1224|Proteobacteria,43BN0@68525|delta/epsilon subdivisions,2X702@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg,dCache_2
k59_1686911_1	78245.Xaut_4054	1.1e-10	62.4	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1686911_2	335543.Sfum_4071	9.57e-64	207.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42MAQ@68525|delta/epsilon subdivisions,2WKK0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iAF987.Gmet_1821	BPD_transp_2
k59_1036002_2	357808.RoseRS_0101	2.33e-27	109.0	2DMC8@1|root,32J63@2|Bacteria	357808.RoseRS_0101|-	L	each copy contains a frameshift at the sequence CCCCCCTTTTT and 7 copies of repeat with repeat unit SCEEP	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_863926_1	1238450.VIBNISOn1_450012	2.79e-86	269.0	COG0069@1|root,COG3369@1|root,COG0069@2|Bacteria,COG3369@2|Bacteria,1MU7B@1224|Proteobacteria,1RP1C@1236|Gammaproteobacteria,1XSHA@135623|Vibrionales	135623|Vibrionales	E	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase,zf-CDGSH
k59_452989_1	1283283.ATXA01000008_gene3170	5.25e-59	187.0	2E61I@1|root,3176Z@2|Bacteria,2HCFB@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1625769_1	1218084.BBJK01000143_gene7409	3.82e-22	101.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,2VK9R@28216|Betaproteobacteria,1K0ZW@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_1744680_1	1005048.CFU_1466	1.7e-78	243.0	COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,2VQ89@28216|Betaproteobacteria,472TR@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_160057_1	305900.GV64_17755	1.65e-59	200.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1XIX5@135619|Oceanospirillales	135619|Oceanospirillales	L	Belongs to the DNA photolyase family	phrB	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_1152637_1	713586.KB900536_gene1537	2.69e-76	245.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,1RR35@1236|Gammaproteobacteria,1WXAB@135613|Chromatiales	135613|Chromatiales	P	TrkA-N domain	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_N
k59_1812508_2	765910.MARPU_12750	8.79e-60	209.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,1RRFS@1236|Gammaproteobacteria,1WW0Y@135613|Chromatiales	135613|Chromatiales	P	TonB-dependent Receptor Plug	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1406396_1	497964.CfE428DRAFT_5468	1.51e-25	110.0	COG5000@1|root,COG5000@2|Bacteria,46THS@74201|Verrucomicrobia	74201|Verrucomicrobia	T	ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_1812510_1	909663.KI867150_gene247	7.23e-109	326.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,42MB7@68525|delta/epsilon subdivisions,2WJVU@28221|Deltaproteobacteria,2MQ96@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1812515_1	1049564.TevJSym_av00160	1.71e-146	428.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,1RQ7G@1236|Gammaproteobacteria,1J4EK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	COG0008 Glutamyl- and glutaminyl-tRNA synthetases	glnS	GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECIAI39_1322.ECIAI39_0637	tRNA-synt_1c,tRNA-synt_1c_C
k59_522626_1	568076.XP_007825961.1	2.12e-07	57.4	COG1020@1|root,COG1022@1|root,KOG1178@2759|Eukaryota,KOG1180@2759|Eukaryota,38HAR@33154|Opisthokonta,3NWBA@4751|Fungi,3QME2@4890|Ascomycota,214YZ@147550|Sordariomycetes,3TDYY@5125|Hypocreales,3G1UF@34397|Clavicipitaceae	4751|Fungi	Q	Condensation domain	-	-	-	ko:K22152	-	-	-	-	ko00000	-	-	-	AMP-binding,Condensation,NAD_binding_4,PP-binding
k59_1166639_1	1068980.ARVW01000001_gene7490	1.26e-35	134.0	COG2755@1|root,COG2755@2|Bacteria,2GKSW@201174|Actinobacteria,4DXHE@85010|Pseudonocardiales	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2,RicinB_lectin_2,Ricin_B_lectin
k59_1232020_1	522306.CAP2UW1_0368	8.15e-35	131.0	COG0304@1|root,COG0304@2|Bacteria,1N91E@1224|Proteobacteria,2VJR3@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabB	-	2.3.1.179,2.3.1.41	ko:K00647,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1232020_2	1158182.KB905021_gene824	2.15e-09	59.3	COG4258@1|root,COG4258@2|Bacteria,1MU1E@1224|Proteobacteria,1RMP8@1236|Gammaproteobacteria,1WW0H@135613|Chromatiales	135613|Chromatiales	S	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	MMPL
k59_1465653_1	1122994.AUFR01000037_gene1164	1.42e-31	126.0	COG0699@1|root,COG0699@2|Bacteria,2GM68@201174|Actinobacteria,4DPRU@85009|Propionibacteriales	201174|Actinobacteria	S	50S ribosome-binding GTPase	PPA1638	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
k59_1406415_1	314285.KT71_03317	2.9e-138	422.0	COG2866@1|root,COG2866@2|Bacteria,1N9W9@1224|Proteobacteria,1RPC7@1236|Gammaproteobacteria,1J7Z8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_1406420_1	1121271.AUCM01000008_gene3210	2.9e-50	174.0	COG0438@1|root,COG0438@2|Bacteria,1R4Q9@1224|Proteobacteria,2TUGJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
k59_809408_1	744980.TRICHSKD4_5728	6.93e-97	290.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	2.7.7.49	ko:K00986,ko:K07497	-	-	-	-	ko00000,ko01000	-	-	-	HTH_32,rve,rve_3
k59_1759230_2	933262.AXAM01000034_gene1556	8e-12	65.1	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,42NF0@68525|delta/epsilon subdivisions,2WIJK@28221|Deltaproteobacteria,2MHPA@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
k59_524508_1	1249627.D779_3323	1.02e-33	130.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria,1WXUR@135613|Chromatiales	135613|Chromatiales	P	PFAM Na Picotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
k59_584034_1	1280954.HPO_01455	6.23e-80	250.0	COG3033@1|root,COG3033@2|Bacteria,1NG5U@1224|Proteobacteria,2TTAU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	catalyzes the formation of indole and pyruvate from tryptophan	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_1584502_1	1035308.AQYY01000001_gene2890	2.76e-23	96.7	COG2138@1|root,COG2138@2|Bacteria	2|Bacteria	S	sirohydrochlorin cobaltochelatase activity	-	-	-	-	-	-	-	-	-	-	-	-	CbiX
k59_1169210_1	1042209.HK44_009290	1.2e-52	177.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,1S248@1236|Gammaproteobacteria,1YNRQ@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	M	MlaA lipoprotein	-	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
k59_1467092_1	377629.TERTU_0695	1.07e-09	61.2	COG0438@1|root,COG0438@2|Bacteria,1QTH1@1224|Proteobacteria,1RXH0@1236|Gammaproteobacteria,2PQHX@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
k59_1467092_2	1278309.KB907109_gene3281	9.62e-34	127.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1XII2@135619|Oceanospirillales	135619|Oceanospirillales	H	Glutamate-1-semialdehyde aminotransferase	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_643551_1	1300345.LF41_1687	1.2e-11	62.4	COG0801@1|root,COG0801@2|Bacteria,1RHNN@1224|Proteobacteria,1S62M@1236|Gammaproteobacteria,1X6J5@135614|Xanthomonadales	135614|Xanthomonadales	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK1	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
k59_643551_2	236097.ADG881_2130	5.93e-55	174.0	COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,1S9B2@1236|Gammaproteobacteria,1XKFN@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
k59_643551_3	527002.yaldo0001_2940	6.56e-43	152.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,41EDU@629|Yersinia	1236|Gammaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_1815106_2	1177181.T9A_01795	3.23e-51	172.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,1RMAE@1236|Gammaproteobacteria,1XIE8@135619|Oceanospirillales	135619|Oceanospirillales	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
k59_703864_2	2340.JV46_11900	7.63e-58	189.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1T02D@1236|Gammaproteobacteria,1J5J9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the dihydroorotate dehydrogenase family	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,NAD_binding_1
k59_524539_2	1121405.dsmv_3344	1.57e-16	73.2	COG2929@1|root,COG2929@2|Bacteria,1N3AZ@1224|Proteobacteria,438DV@68525|delta/epsilon subdivisions,2WXRG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
k59_703880_1	768671.ThimaDRAFT_2921	4.34e-63	208.0	COG3659@1|root,COG3659@2|Bacteria,1PGW8@1224|Proteobacteria,1SHC7@1236|Gammaproteobacteria	2|Bacteria	M	Carbohydrate-selective porin, OprB family	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB,SLH
k59_469096_1	316055.RPE_3687	1.51e-80	250.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,3JTEF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	MA20_27205	-	3.6.3.30	ko:K02010,ko:K10112	ko02010,map02010	M00190,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.10	-	-	ABC_tran,TOBE,TOBE_2
k59_1815164_1	278963.ATWD01000002_gene675	4.78e-39	143.0	COG1562@1|root,COG1562@2|Bacteria,3Y63M@57723|Acidobacteria,2JKBY@204432|Acidobacteriia	204432|Acidobacteriia	I	Squalene/phytoene synthase	-	-	2.5.1.21	ko:K00801	ko00100,ko00909,ko01100,ko01110,ko01130,map00100,map00909,map01100,map01110,map01130	-	R00702,R02872,R06223	RC00362,RC00796,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	SQS_PSY
k59_703915_1	1304865.JAGF01000001_gene1323	2.59e-90	289.0	COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,2GKXQ@201174|Actinobacteria,4F1SJ@85016|Cellulomonadaceae	201174|Actinobacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
k59_1467189_1	367299.JOEE01000010_gene3353	1.53e-61	199.0	COG0331@1|root,COG0331@2|Bacteria,2GME0@201174|Actinobacteria,4FFAJ@85021|Intrasporangiaceae	201174|Actinobacteria	I	Biotin attachment protein	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005835,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
k59_584102_1	1129794.C427_0217	2.32e-24	100.0	COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,1RR3K@1236|Gammaproteobacteria,469GM@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Domain related to MnhB subunit of Na+/H+ antiporter	-	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB
k59_584102_2	1121937.AUHJ01000004_gene966	5.79e-34	120.0	COG1320@1|root,COG1320@2|Bacteria,1QTGI@1224|Proteobacteria,1RTH6@1236|Gammaproteobacteria,468PE@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Na+/H+ antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_524604_1	1343740.M271_24185	2.76e-21	90.5	COG0789@1|root,COG0789@2|Bacteria,2GNID@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR_1
k59_524604_2	561175.KB894093_gene3940	1.96e-38	137.0	COG1569@1|root,COG1569@2|Bacteria,2IMP1@201174|Actinobacteria,4EJUU@85012|Streptosporangiales	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
k59_524604_3	1146883.BLASA_0251	1.59e-33	120.0	COG3311@1|root,COG3311@2|Bacteria,2IQFY@201174|Actinobacteria	201174|Actinobacteria	K	DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
k59_1169342_1	994479.GL877878_gene1294	1.1e-82	270.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4DY9U@85010|Pseudonocardiales	201174|Actinobacteria	C	aconitate hydratase	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_524615_1	1266914.ATUK01000014_gene2049	2.78e-56	192.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,1RPBP@1236|Gammaproteobacteria,1WZ40@135613|Chromatiales	135613|Chromatiales	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
k59_1759346_1	258594.RPA2260	4.75e-48	177.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,2TVG8@28211|Alphaproteobacteria,3K389@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	AAA domain	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2,Viral_helicase1
k59_469196_1	439235.Dalk_2136	3.18e-13	69.3	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,42PVD@68525|delta/epsilon subdivisions,2WM2C@28221|Deltaproteobacteria,2MIPY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Pfam:UPF0118	-	-	-	ko:K03548	-	-	-	-	ko00000,ko02000	2.A.86.1	-	-	AI-2E_transport
k59_469196_2	335543.Sfum_1817	4.78e-14	72.4	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MRH3@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	ABC1 family	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,RIO1
k59_584119_1	697282.Mettu_1844	1.11e-53	186.0	COG4590@1|root,COG4590@2|Bacteria,1QTTD@1224|Proteobacteria,1T1GK@1236|Gammaproteobacteria,1XEGE@135618|Methylococcales	135618|Methylococcales	P	PFAM Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_584119_2	498211.CJA_2780	1.85e-40	150.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,1FGRD@10|Cellvibrio	1236|Gammaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_524641_2	56780.SYN_00186	1.6e-41	141.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,42U00@68525|delta/epsilon subdivisions,2WQD4@28221|Deltaproteobacteria,2MQKE@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Biopolymer transport protein ExbD/TolR	tolR	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
k59_524646_1	1540257.JQMW01000013_gene1186	7.38e-22	96.3	COG0025@1|root,COG0025@2|Bacteria,1UHUI@1239|Firmicutes,25E2Y@186801|Clostridia,36UH5@31979|Clostridiaceae	186801|Clostridia	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1759369_1	1128421.JAGA01000002_gene938	1.32e-69	217.0	COG0302@1|root,COG0302@2|Bacteria,2NPAT@2323|unclassified Bacteria	2|Bacteria	H	GTP cyclohydrolase I	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
k59_1759377_2	485913.Krac_4386	5.28e-61	204.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_643702_2	251221.35211365	1.4e-17	75.9	2E3AG@1|root,32Y9Z@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_584150_1	1286631.X805_30980	2.49e-23	104.0	COG1858@1|root,COG1858@2|Bacteria,1MWAT@1224|Proteobacteria,2W0SH@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Di-haem cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG
k59_469262_1	631362.Thi970DRAFT_03886	1.45e-33	130.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,1RYCJ@1236|Gammaproteobacteria,1WWJG@135613|Chromatiales	135613|Chromatiales	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
k59_1815330_1	713586.KB900536_gene1549	2.88e-100	309.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1WW0Q@135613|Chromatiales	135613|Chromatiales	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_469278_1	748658.KB907320_gene861	1.9e-19	86.7	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales	135613|Chromatiales	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
k59_1407987_1	518766.Rmar_0089	4.74e-54	192.0	COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1FIP6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1641742_1	926569.ANT_16780	7.29e-47	154.0	COG0509@1|root,COG0509@2|Bacteria,2G6XE@200795|Chloroflexi	200795|Chloroflexi	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
k59_1815365_1	1126627.BAWE01000004_gene4067	4.86e-73	233.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,3JTY7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_704040_2	1038860.AXAP01000128_gene3947	2.98e-23	95.1	COG2146@1|root,COG2146@2|Bacteria,1N72F@1224|Proteobacteria,2UFDN@28211|Alphaproteobacteria,3JYII@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_704040_3	937777.Deipe_1222	4.27e-37	132.0	COG2095@1|root,COG2095@2|Bacteria,1WJXY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	U	UPF0056 membrane protein	marC	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
k59_1641743_1	879212.DespoDRAFT_00577	1.44e-64	212.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N38@68525|delta/epsilon subdivisions,2WK56@28221|Deltaproteobacteria,2MHP9@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Di-haem cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG
k59_524694_1	1219076.N646_2654	8.52e-21	92.0	COG3945@1|root,COG3945@2|Bacteria,1NDGV@1224|Proteobacteria,1SGA3@1236|Gammaproteobacteria,1XWZS@135623|Vibrionales	135623|Vibrionales	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
k59_811054_1	1123400.KB904760_gene2096	2.63e-66	211.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,460DA@72273|Thiotrichales	72273|Thiotrichales	Q	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
k59_1759419_1	944560.HMPREF9058_1751	1.2e-16	88.6	COG1983@1|root,COG1983@2|Bacteria,2GIVS@201174|Actinobacteria,4D3S5@85005|Actinomycetales	201174|Actinobacteria	KT	PspC domain protein	pspC	-	-	-	-	-	-	-	-	-	-	-	DUF2154,PspC
k59_1759420_1	768671.ThimaDRAFT_3674	2.22e-10	60.8	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,1WXGF@135613|Chromatiales	135613|Chromatiales	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_1759420_2	765911.Thivi_0915	2.25e-57	186.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1WW2U@135613|Chromatiales	135613|Chromatiales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_704052_1	1448389.BAVQ01000071_gene2497	1.65e-19	88.6	COG3177@1|root,COG3177@2|Bacteria,2GN3K@201174|Actinobacteria	201174|Actinobacteria	K	Filamentation induced by cAMP protein fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N
k59_524711_1	948106.AWZT01000053_gene1579	1.01e-74	239.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,2VMJ9@28216|Betaproteobacteria,1K26K@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Uncharacterized protein family (UPF0051)	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_469353_1	1122138.AQUZ01000019_gene8185	2.45e-13	70.5	COG2267@1|root,COG2267@2|Bacteria,2GJUE@201174|Actinobacteria,4DQUJ@85009|Propionibacteriales	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
k59_811077_1	930171.Asphe3_19870	2.31e-49	171.0	COG0452@1|root,COG0452@2|Bacteria,2GJGJ@201174|Actinobacteria,1W7NF@1268|Micrococcaceae	201174|Actinobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k59_524727_1	247490.KSU1_C1256	1.57e-71	229.0	COG0579@1|root,COG0579@2|Bacteria,2IX3W@203682|Planctomycetes	203682|Planctomycetes	S	FAD dependent oxidoreductase	-	-	-	ko:K15736	-	-	-	-	ko00000,ko01000	-	-	-	DAO
k59_643791_1	1121405.dsmv_2066	8.8e-89	272.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42NH6@68525|delta/epsilon subdivisions,2WJCV@28221|Deltaproteobacteria,2MHTU@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	dapL	GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_469399_1	1496688.ER33_07210	7.49e-59	187.0	COG2370@1|root,COG2370@2|Bacteria,1G89Z@1117|Cyanobacteria	1117|Cyanobacteria	O	Hydrogenase urease accessory protein	-	-	-	ko:K03192	-	-	-	-	ko00000	-	-	-	HupE_UreJ
k59_469399_2	585423.KR49_03385	8.33e-09	55.8	COG2370@1|root,COG2370@2|Bacteria,1GN8Y@1117|Cyanobacteria,1H0JQ@1129|Synechococcus	1117|Cyanobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ
k59_1467404_1	1122611.KB904007_gene7791	9.23e-69	215.0	COG0491@1|root,COG0491@2|Bacteria,2GJU0@201174|Actinobacteria,4EHV3@85012|Streptosporangiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
k59_469413_1	1249627.D779_0584	1.14e-76	255.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales	135613|Chromatiales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1467412_2	1121875.KB907550_gene638	2.35e-35	132.0	COG5361@1|root,COG5361@2|Bacteria,4NKSK@976|Bacteroidetes,1IARY@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_469447_1	640081.Dsui_1434	1.55e-26	108.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2VMPX@28216|Betaproteobacteria,2KUUF@206389|Rhodocyclales	206389|Rhodocyclales	H	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
k59_1467436_1	397278.JOJN01000002_gene244	1.21e-52	186.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2GKI9@201174|Actinobacteria,4DN5D@85009|Propionibacteriales	201174|Actinobacteria	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_811124_1	380358.XALC_0930	4.29e-140	416.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1X34C@135614|Xanthomonadales	135614|Xanthomonadales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	cyoB	-	1.10.3.10	ko:K02298	ko00190,ko01100,map00190,map01100	M00417	R11335	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.5	-	-	COX1
k59_710158_2	313589.JNB_13293	1.95e-255	718.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4FFVB@85021|Intrasporangiaceae	201174|Actinobacteria	G	alpha-glucosidase	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_710158_3	864702.OsccyDRAFT_0095	8.78e-40	163.0	COG2114@1|root,COG5000@1|root,COG2114@2|Bacteria,COG5000@2|Bacteria,1G2T0@1117|Cyanobacteria,1H6XI@1150|Oscillatoriales	1117|Cyanobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Globin,Guanylate_cyc,HAMP,dCache_1
k59_242206_1	1517416.IDAT_02085	5.1e-32	127.0	2C3QV@1|root,2Z7YP@2|Bacteria,1MXAM@1224|Proteobacteria,1RNIA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
k59_1179738_1	553385.JEMF01000074_gene1366	1.39e-103	322.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1XIN2@135619|Oceanospirillales	135619|Oceanospirillales	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_1649677_1	1120956.JHZK01000013_gene2564	5.1e-26	106.0	COG0697@1|root,COG0697@2|Bacteria,1MY2U@1224|Proteobacteria,2TV71@28211|Alphaproteobacteria,1JQ3C@119043|Rhodobiaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
k59_1414834_1	396588.Tgr7_3208	5.27e-77	240.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1WX4T@135613|Chromatiales	135613|Chromatiales	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_8334_1	1151119.KB895489_gene501	4.98e-70	225.0	COG2072@1|root,COG2072@2|Bacteria,2GM3S@201174|Actinobacteria	201174|Actinobacteria	P	oxidoreductase	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
k59_889092_1	1452718.JBOY01000062_gene1671	0.000209	45.1	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_889092_2	765914.ThisiDRAFT_0005	5.53e-35	124.0	COG0693@1|root,COG0693@2|Bacteria,1N7T2@1224|Proteobacteria,1RSBI@1236|Gammaproteobacteria,1WY2E@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM DJ-1 family protein	-	-	3.5.1.124	ko:K03152	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
k59_1300222_1	566466.NOR53_52	3.6e-77	241.0	COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,1RNUH@1236|Gammaproteobacteria,1J7FF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	yejE	-	-	ko:K13895	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1
k59_1239009_1	1085623.GNIT_1472	6.53e-36	137.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,464A9@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	mltD	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_1473936_1	870187.Thini_0762	4.35e-83	259.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,46046@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_1708046_1	396588.Tgr7_2946	6.14e-21	92.4	2DQ0C@1|root,33473@2|Bacteria,1NAM4@1224|Proteobacteria,1SCY6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
k59_1708046_2	500640.CIT292_09594	2.57e-50	170.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,3WVC7@544|Citrobacter	1236|Gammaproteobacteria	L	FES	mutY	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
k59_360763_1	864702.OsccyDRAFT_1783	6.81e-18	90.1	COG1404@1|root,COG3209@1|root,COG4932@1|root,COG1404@2|Bacteria,COG3209@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,RHS_repeat,SdrD_B
k59_827366_1	323261.Noc_0241	1.86e-43	158.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1WWSQ@135613|Chromatiales	135613|Chromatiales	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_827366_2	62928.azo0781	3.88e-95	287.0	COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,2VIU8@28216|Betaproteobacteria,2KV4Z@206389|Rhodocyclales	206389|Rhodocyclales	P	Mg2 and Co2 transporter CorC	-	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
k59_68382_1	156889.Mmc1_1409	6e-71	232.0	COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0471 Di- and tricarboxylate transporters	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_476114_1	1049564.TevJSym_aq00120	2.31e-55	174.0	2F88A@1|root,340MG@2|Bacteria,1NXS1@1224|Proteobacteria,1SQ1P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Phosphoribosyl-ATP pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG
k59_476114_2	472759.Nhal_0219	2.34e-62	212.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1WWSJ@135613|Chromatiales	135613|Chromatiales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_300120_1	547042.BACCOPRO_01514	5.56e-23	101.0	COG0704@1|root,COG0704@2|Bacteria,4NNT5@976|Bacteroidetes,2FNP4@200643|Bacteroidia,4AM4G@815|Bacteroidaceae	976|Bacteroidetes	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_300120_2	1392487.JIAD01000001_gene930	5.3e-33	126.0	COG1270@1|root,COG1270@2|Bacteria,1TQ3X@1239|Firmicutes,247PR@186801|Clostridia,25UVZ@186806|Eubacteriaceae	186801|Clostridia	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
k59_361872_1	233412.HD_0555	4.05e-13	71.2	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,1Y76A@135625|Pasteurellales	135625|Pasteurellales	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_361872_2	1260251.SPISAL_02640	2.78e-20	90.5	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1WWGT@135613|Chromatiales	135613|Chromatiales	S	Permease YjgP YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_890171_1	1298867.AUES01000051_gene4507	2.66e-56	192.0	COG0845@1|root,COG0845@2|Bacteria,1N97Q@1224|Proteobacteria,2U22Z@28211|Alphaproteobacteria,3K3DU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,GAF,HlyD_3,HlyD_D23
k59_361880_2	767817.Desgi_2097	1.34e-10	62.4	COG0047@1|root,COG0047@2|Bacteria,1TP1B@1239|Firmicutes,24A2E@186801|Clostridia,260V1@186807|Peptococcaceae	186801|Clostridia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
k59_1415678_1	765913.ThidrDRAFT_0469	1.39e-81	265.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1X08T@135613|Chromatiales	135613|Chromatiales	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_123967_1	290397.Adeh_1659	1.89e-54	187.0	COG3005@1|root,COG3005@2|Bacteria,1R956@1224|Proteobacteria,42Q0X@68525|delta/epsilon subdivisions,2WMHI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
k59_476127_1	368408.Tpen_1760	1.33e-77	244.0	COG0731@1|root,arCOG00953@2157|Archaea,2XQMI@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_768689_1	1499967.BAYZ01000176_gene5691	6.28e-26	104.0	COG2801@1|root,COG2801@2|Bacteria,2NQ28@2323|unclassified Bacteria	2|Bacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve,rve_3
k59_1767161_1	1193181.BN10_50006	2.35e-14	67.8	2DRBI@1|root,33B4D@2|Bacteria,2GUQT@201174|Actinobacteria,4FHW9@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1590995_1	1267005.KB911257_gene931	2.25e-61	197.0	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2TVBT@28211|Alphaproteobacteria,3N73R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
k59_1180676_1	1150864.MILUP08_46621	3.62e-48	167.0	COG3642@1|root,COG3642@2|Bacteria,2GIX0@201174|Actinobacteria,4D9BS@85008|Micromonosporales	201174|Actinobacteria	T	Domain of unknown function (DUF4032)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4032,Kdo
k59_182708_1	1121930.AQXG01000001_gene1203	1.06e-43	160.0	COG0841@1|root,COG0841@2|Bacteria,4NGCI@976|Bacteroidetes	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_182708_2	1123053.AUDG01000010_gene1553	5.43e-07	50.8	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WXV4@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_1240134_1	95619.PM1_0217265	1.49e-48	177.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019538,GO:0019752,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0070569,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_1240134_2	1121923.GPUN_1416	9.36e-08	53.1	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria,46498@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Methionine aminopeptidase	map	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_68424_1	1301098.PKB_4797	1.54e-97	295.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0042380,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046490,GO:0048037,GO:0051536,GO:0051538,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI1_1343.ECIAI1_0030,iECW_1372.ECW_m0028,iEKO11_1354.EKO11_3884,iEcHS_1320.EcHS_A0031,iEcolC_1368.EcolC_3626,iPC815.YPO0477,iSFV_1184.SFV_0023,iSF_1195.SF0026,iSFxv_1172.SFxv_0027,iS_1188.S0028,iWFL_1372.ECW_m0028,iYL1228.KPN_00024	LYTB
k59_300152_1	358823.DF19_12325	1.26e-64	212.0	COG4638@1|root,COG4638@2|Bacteria,2GMB2@201174|Actinobacteria	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
k59_890202_1	448385.sce3271	4.33e-15	80.1	COG0406@1|root,COG0406@2|Bacteria,1QNKS@1224|Proteobacteria,434AH@68525|delta/epsilon subdivisions,2WYK2@28221|Deltaproteobacteria,2Z1NH@29|Myxococcales	28221|Deltaproteobacteria	G	Phosphoglycerate mutase family	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
k59_1532563_1	391937.NA2_11719	2.24e-06	48.5	COG1638@1|root,COG1638@2|Bacteria,1MWAW@1224|Proteobacteria,2TV91@28211|Alphaproteobacteria,43NPF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	MA20_30160	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1532563_2	1123355.JHYO01000050_gene788	7.41e-64	201.0	COG3090@1|root,COG3090@2|Bacteria,1MVKS@1224|Proteobacteria,2U08K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG3090 TRAP-type C4-dicarboxylate transport system small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_1532563_3	883080.HMPREF9697_00863	9.75e-59	194.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,3JTXU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	MA20_30170	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1708735_1	1120705.FG95_00671	8.44e-27	117.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2TS8I@28211|Alphaproteobacteria,2K03B@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	nirB	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
k59_1240150_1	644801.Psest_0531	5.88e-92	280.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,1Z0Z0@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	T	phosphate starvation-inducible protein PhoH	ybeZ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_1301349_1	713586.KB900538_gene7	4.25e-89	271.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1WX4T@135613|Chromatiales	135613|Chromatiales	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_534959_1	519989.ECTPHS_07112	3.82e-22	89.4	COG0394@1|root,COG0394@2|Bacteria,1RHA3@1224|Proteobacteria,1S676@1236|Gammaproteobacteria,1X2GD@135613|Chromatiales	135613|Chromatiales	T	Low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
k59_534959_2	391615.ABSJ01000041_gene49	1.15e-35	125.0	COG0346@1|root,COG0346@2|Bacteria,1RHIV@1224|Proteobacteria,1S6V6@1236|Gammaproteobacteria,1JARQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	cadI	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_1415711_1	396588.Tgr7_0573	3.87e-91	278.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria,1WX3F@135613|Chromatiales	135613|Chromatiales	E	Belongs to the peptidase M20A family. ArgE subfamily	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1708742_1	247639.MGP2080_05997	3.47e-174	498.0	COG0446@1|root,COG0446@2|Bacteria,1Q0P8@1224|Proteobacteria,1T1NQ@1236|Gammaproteobacteria,1J7YY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	1.14.19.9	ko:K14266	ko00404,ko01130,map00404,map01130	M00789,M00790	R09570	RC00949	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_halogenase
k59_890216_1	1133850.SHJG_8792	1.3e-42	154.0	29KBT@1|root,30793@2|Bacteria,2IE0E@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	vATP-synt_AC39
k59_890216_2	55952.BU52_26000	5.25e-108	333.0	COG1269@1|root,COG1269@2|Bacteria,2I9VH@201174|Actinobacteria	201174|Actinobacteria	C	V-type ATPase 116kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_9985_1	290318.Cvib_0707	8.57e-07	57.0	COG0658@1|root,COG0658@2|Bacteria,1FDMW@1090|Chlorobi	1090|Chlorobi	S	PFAM ComEC Rec2-related protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131
k59_9985_2	1565129.JSFF01000004_gene3120	8.6e-46	157.0	COG1054@1|root,COG1054@2|Bacteria,1MUFV@1224|Proteobacteria,1RNNU@1236|Gammaproteobacteria,2Q9B4@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Belongs to the UPF0176 family	yceA	-	-	ko:K07146	-	-	-	-	ko00000	-	-	-	Rhodanese,Rhodanese_C
k59_1063968_1	243277.VC_0473	2.01e-133	401.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1XSX1@135623|Vibrionales	135623|Vibrionales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	GO:0003674,GO:0003824,GO:0004802,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009987,GO:0016740,GO:0016744,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_9994_1	1238182.C882_1896	4.46e-23	100.0	COG3677@1|root,COG3677@2|Bacteria,1R999@1224|Proteobacteria,2UD3G@28211|Alphaproteobacteria,2JXD2@204441|Rhodospirillales	204441|Rhodospirillales	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_828215_1	857087.Metme_1534	5.08e-134	393.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,1XE3C@135618|Methylococcales	135618|Methylococcales	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
k59_1180716_1	1042375.AFPL01000022_gene2549	4.5e-53	181.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	VP1997	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_534974_1	1380394.JADL01000007_gene4493	1.81e-21	87.4	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2U72U@28211|Alphaproteobacteria,2JT8V@204441|Rhodospirillales	204441|Rhodospirillales	S	Iron-sulfur cluster assembly protein	sufT	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
k59_534974_2	1123517.JOMR01000001_gene1734	3.23e-45	149.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,1S5XD@1236|Gammaproteobacteria,4614P@72273|Thiotrichales	72273|Thiotrichales	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
k59_534974_3	1255043.TVNIR_2976	5.95e-27	101.0	COG2166@1|root,COG2166@2|Bacteria,1RI8F@1224|Proteobacteria,1S65C@1236|Gammaproteobacteria,1WY7Q@135613|Chromatiales	135613|Chromatiales	S	PFAM Fe-S metabolism associated	-	-	-	ko:K02426	-	-	-	-	ko00000	-	-	-	SufE
k59_300181_1	1198232.CYCME_0641	2.38e-76	236.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,460H9@72273|Thiotrichales	72273|Thiotrichales	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	cyoE	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_1356650_2	1713.JOFV01000001_gene2035	6.51e-85	267.0	COG2148@1|root,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria,4F2AD@85016|Cellulomonadaceae	201174|Actinobacteria	M	CoA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
k59_1532588_1	522306.CAP2UW1_0195	2.45e-64	215.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VNNI@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_593598_1	1131553.JIBI01000025_gene138	7.1e-90	294.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2VKDG@28216|Betaproteobacteria,371PE@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
k59_68487_1	868131.MSWAN_0001	1.23e-42	150.0	COG1192@1|root,arCOG00586@2157|Archaea,2XV5C@28890|Euryarchaeota,23NK6@183925|Methanobacteria	183925|Methanobacteria	D	PFAM Cobyrinic acid a,c-diamide synthase	minD	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_593602_2	1121085.AUCI01000003_gene3423	1.66e-08	50.8	29XEQ@1|root,30J4Y@2|Bacteria,1U437@1239|Firmicutes,4IDV7@91061|Bacilli,1ZJYP@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1475170_1	631362.Thi970DRAFT_01524	6.59e-129	385.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RNES@1236|Gammaproteobacteria,1X2HE@135613|Chromatiales	135613|Chromatiales	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1532599_1	1123399.AQVE01000023_gene422	1.64e-18	89.7	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,45ZVF@72273|Thiotrichales	72273|Thiotrichales	NU	Type II and III secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	Secretin,Secretin_N
k59_949196_1	439496.RBY4I_3671	1.77e-106	317.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_1003666_1	479431.Namu_2680	5.23e-66	218.0	COG1674@1|root,COG1674@2|Bacteria,2IERX@201174|Actinobacteria	201174|Actinobacteria	D	Participates in initiation and elongation during chromosome replication	-	-	-	-	-	-	-	-	-	-	-	-	FtsK_SpoIIIE
k59_593607_2	114615.BRADO4390	2.33e-20	91.7	COG3497@1|root,COG3497@2|Bacteria,1MX89@1224|Proteobacteria,2TVB3@28211|Alphaproteobacteria,3K07D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
k59_652418_2	525904.Tter_0314	8.49e-100	308.0	COG0165@1|root,COG0165@2|Bacteria,2NP70@2323|unclassified Bacteria	2|Bacteria	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Lyase_1
k59_828245_1	1457250.BBMO01000002_gene2913	1.19e-09	58.9	COG2514@1|root,arCOG06106@2157|Archaea,2XU95@28890|Euryarchaeota,23TJK@183963|Halobacteria	183963|Halobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
k59_1064035_1	1121405.dsmv_1640	3.76e-131	402.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42QS7@68525|delta/epsilon subdivisions,2X74U@28221|Deltaproteobacteria,2MN9G@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,Acyltransferase,PP-binding
k59_602479_1	1198232.CYCME_0496	3e-44	151.0	COG2996@1|root,COG2996@2|Bacteria,1MXC3@1224|Proteobacteria,1RS4D@1236|Gammaproteobacteria,460K1@72273|Thiotrichales	72273|Thiotrichales	S	S1 domain	-	-	-	ko:K00243	-	-	-	-	ko00000	-	-	-	S1_2
k59_1314422_1	1049564.TevJSym_cx00010	3.02e-59	201.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria,1JAD3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1541853_1	177439.DP0617	1.82e-115	343.0	COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria	1224|Proteobacteria	E	aminotransferase	aspC	GO:0003674,GO:0003824,GO:0004069,GO:0004838,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006558,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0033585,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0070279,GO:0070547,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223	2.6.1.1,2.6.1.57	ko:K00813,ko:K00832	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	M00024,M00025,M00034,M00040	R00355,R00694,R00734,R00896,R01731,R02433,R02619,R05052,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iPC815.YPO1410,iSFxv_1172.SFxv_1000	Aminotran_1_2
k59_1425461_1	933262.AXAM01000017_gene3105	2.18e-52	182.0	COG4191@1|root,COG4191@2|Bacteria,1R9AK@1224|Proteobacteria,42Q2G@68525|delta/epsilon subdivisions,2WM8Y@28221|Deltaproteobacteria,2MI84@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_1078813_1	1249627.D779_3819	9.12e-73	223.0	COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,1S2AY@1236|Gammaproteobacteria,1WY14@135613|Chromatiales	135613|Chromatiales	T	PFAM Phosphoglycerate mutase	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
k59_485337_1	316055.RPE_3203	3.73e-75	236.0	COG0045@1|root,COG0045@2|Bacteria,1R3UY@1224|Proteobacteria,2TVQC@28211|Alphaproteobacteria,3JX19@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Belongs to the succinate malate CoA ligase beta subunit family	-	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_1365926_1	590998.Celf_2027	1.02e-215	620.0	COG0342@1|root,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4F1XH@85016|Cellulomonadaceae	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_1365926_2	1123065.ATWL01000001_gene229	1.43e-151	438.0	COG0341@1|root,COG0341@2|Bacteria,2GJRS@201174|Actinobacteria	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_544109_1	314278.NB231_10523	1.32e-86	265.0	COG1980@1|root,COG1980@2|Bacteria,1MXM7@1224|Proteobacteria,1SKUG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	-	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
k59_602488_1	1121405.dsmv_2795	2.56e-07	52.0	COG2223@1|root,COG2223@2|Bacteria,1MWC7@1224|Proteobacteria,42P53@68525|delta/epsilon subdivisions,2WJ2U@28221|Deltaproteobacteria,2MIZU@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
k59_602488_2	521460.Athe_0791	9.05e-16	79.3	COG1994@1|root,COG1994@2|Bacteria,1V6D4@1239|Firmicutes,24K0D@186801|Clostridia,42FD9@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM peptidase M50	ywhC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
k59_544113_1	1463903.JOIZ01000016_gene872	1.43e-56	192.0	COG2373@1|root,COG2373@2|Bacteria,2H4M3@201174|Actinobacteria	201174|Actinobacteria	I	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,Catalase
k59_1425473_1	765910.MARPU_00770	2.33e-70	226.0	COG2334@1|root,COG2334@2|Bacteria,1Q18Y@1224|Proteobacteria,1RR8Y@1236|Gammaproteobacteria,1WWTK@135613|Chromatiales	135613|Chromatiales	S	Phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_837772_1	765913.ThidrDRAFT_1210	5.07e-75	232.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,1RPYX@1236|Gammaproteobacteria,1WX9X@135613|Chromatiales	135613|Chromatiales	O	PFAM Peptidase M22, glycoprotease	-	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
k59_837772_2	765913.ThidrDRAFT_2857	4.78e-47	167.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1WWG0@135613|Chromatiales	135613|Chromatiales	L	Helicase	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
k59_1190498_1	439235.Dalk_2557	1.66e-52	184.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2MIGI@213118|Desulfobacterales	68525|delta/epsilon subdivisions	C	PFAM molybdopterin oxidoreductase	nuoG-1	-	1.17.1.10,1.6.5.3	ko:K00336,ko:K05299	ko00190,ko00680,ko00720,ko01100,ko01120,ko01200,map00190,map00680,map00720,map01100,map01120,map01200	M00144,M00377	R00134,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_3349	Fer2_4,Fer4,Fer4_10,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1487912_1	1123065.ATWL01000001_gene187	4.43e-99	291.0	2AIF4@1|root,318WM@2|Bacteria,2GK8R@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3000)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3000
k59_1842623_1	83406.HDN1F_06230	5.47e-11	68.2	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1J4SY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function	yhdP	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_1252940_1	713586.KB900536_gene2913	1.68e-104	315.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1WWW0@135613|Chromatiales	135613|Chromatiales	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
k59_1600179_1	926550.CLDAP_25780	1.1e-27	115.0	COG0195@1|root,COG0195@2|Bacteria,2G5M5@200795|Chloroflexi	200795|Chloroflexi	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
k59_1487913_1	935839.JAGJ01000001_gene1048	6.09e-101	305.0	COG0673@1|root,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria,4F49F@85017|Promicromonosporaceae	201174|Actinobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_544121_1	1123354.AUDR01000018_gene1159	1.3e-24	97.8	COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,2VU0P@28216|Betaproteobacteria,1KRV7@119069|Hydrogenophilales	119069|Hydrogenophilales	U	Preprotein translocase SecG subunit	-	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
k59_375047_1	1095769.CAHF01000022_gene105	4.49e-48	175.0	COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,2VMBE@28216|Betaproteobacteria,472MV@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_6,Fer4_7
k59_1011278_1	1278307.KB907009_gene3392	2e-34	135.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1314452_1	1282876.BAOK01000002_gene77	1.33e-156	455.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,4BPK3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_259026_1	292459.STH2902	7.18e-14	75.5	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1487920_1	338969.Rfer_2513	6.5e-76	238.0	COG0477@1|root,COG2814@2|Bacteria,1MXPM@1224|Proteobacteria,2VHXT@28216|Betaproteobacteria,4A9YQ@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_903292_1	314345.SPV1_11011	2.07e-94	288.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria	1224|Proteobacteria	P	COG0530 Ca2 Na antiporter	yrbG	GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005262,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006816,GO:0006873,GO:0006874,GO:0006875,GO:0008150,GO:0008273,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015081,GO:0015085,GO:0015267,GO:0015291,GO:0015297,GO:0015298,GO:0015318,GO:0015368,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0019725,GO:0022803,GO:0022804,GO:0022821,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030955,GO:0031224,GO:0031226,GO:0031402,GO:0031420,GO:0034220,GO:0035725,GO:0042592,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070588,GO:0070838,GO:0071804,GO:0071805,GO:0071944,GO:0072503,GO:0072507,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	iAPECO1_1312.APECO1_3239,iECABU_c1320.ECABU_c36110,iECNA114_1301.ECNA114_3275,iECOK1_1307.ECOK1_3617,iECS88_1305.ECS88_3578,iECSF_1327.ECSF_3028,iUMN146_1321.UM146_00400,iUTI89_1310.UTI89_C3632,ic_1306.c3956	Na_Ca_ex
k59_375064_1	765912.Thimo_1807	1.29e-41	142.0	COG5622@1|root,COG5622@2|Bacteria,1N6XP@1224|Proteobacteria,1SCD9@1236|Gammaproteobacteria,1WYG0@135613|Chromatiales	135613|Chromatiales	N	Host attachment protein	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach
k59_720729_1	187272.Mlg_1372	5.44e-82	259.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1WWI5@135613|Chromatiales	135613|Chromatiales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_485370_1	935839.JAGJ01000006_gene3274	2.26e-68	221.0	COG0812@1|root,COG0812@2|Bacteria,2GIV2@201174|Actinobacteria,4F3DC@85017|Promicromonosporaceae	201174|Actinobacteria	M	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
k59_1129972_1	1307437.J139_06137	7.2e-09	55.8	COG3186@1|root,COG3186@2|Bacteria,1MU29@1224|Proteobacteria,1RQBJ@1236|Gammaproteobacteria,2PZVI@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	E	COG3186 Phenylalanine-4-hydroxylase	phhA	GO:0003674,GO:0003824,GO:0004497,GO:0004505,GO:0006082,GO:0006520,GO:0006558,GO:0006559,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009987,GO:0016054,GO:0016491,GO:0016705,GO:0016714,GO:0017144,GO:0019439,GO:0019752,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902221,GO:1902222	1.14.16.1	ko:K00500	ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230	-	R01795,R07211	RC00490	ko00000,ko00001,ko01000	-	-	-	Biopterin_H
k59_1129972_2	519989.ECTPHS_12099	4.86e-217	608.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,1WW8H@135613|Chromatiales	135613|Chromatiales	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_376476_1	1121374.KB891585_gene1941	2.36e-42	152.0	COG0438@1|root,COG0438@2|Bacteria,1NA28@1224|Proteobacteria,1RQBV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0438 Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3524,Glyco_trans_1_4,Glycos_transf_1
k59_777189_1	870187.Thini_0300	2.69e-90	276.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,45ZQ6@72273|Thiotrichales	72273|Thiotrichales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1080226_1	710696.Intca_2645	1.12e-166	496.0	COG1835@1|root,COG1835@2|Bacteria,2GKI5@201174|Actinobacteria,4FI7P@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_26715_2	396588.Tgr7_0222	6.72e-47	164.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1WVY6@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
k59_1315910_1	305700.B447_11882	2.24e-45	157.0	COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,2VNUN@28216|Betaproteobacteria,2KWSZ@206389|Rhodocyclales	206389|Rhodocyclales	Q	DSBA Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
k59_603500_1	425104.Ssed_2702	4.64e-56	178.0	COG0454@1|root,COG0456@2|Bacteria,1N6QA@1224|Proteobacteria,1SDXW@1236|Gammaproteobacteria,2QC7W@267890|Shewanellaceae	1236|Gammaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
k59_1718805_1	935839.JAGJ01000010_gene334	6.47e-109	334.0	COG0747@1|root,COG0747@2|Bacteria,2GMMG@201174|Actinobacteria,4F4CW@85017|Promicromonosporaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1366968_1	1535422.ND16A_1887	3.72e-148	430.0	COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,1RQ1A@1236|Gammaproteobacteria,2Q6Q9@267889|Colwelliaceae	1236|Gammaproteobacteria	M	PFAM membrane bound O-acyl transferase MBOAT family protein	patA	-	-	-	-	-	-	-	-	-	-	-	MBOAT
k59_486365_1	572477.Alvin_3061	1.19e-74	237.0	COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,1RPY4@1236|Gammaproteobacteria,1WX0J@135613|Chromatiales	135613|Chromatiales	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_1489153_2	983545.Glaag_1728	2.24e-39	142.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,46540@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	GO:0003674,GO:0003824,GO:0004076,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	iZ_1308.Z0994	BATS,Radical_SAM
k59_904742_1	1336233.JAEH01000046_gene3789	9.66e-77	244.0	COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,1RZYZ@1236|Gammaproteobacteria,2QATI@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_663065_1	1150600.ADIARSV_3147	8.85e-18	84.7	COG0704@1|root,COG0704@2|Bacteria,4NNT5@976|Bacteroidetes,1ISF5@117747|Sphingobacteriia	976|Bacteroidetes	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_1489156_1	1397666.RS24_01315	7.91e-68	229.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2TRQG@28211|Alphaproteobacteria,4BPS7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
k59_1489156_2	1532558.JL39_27855	6.71e-07	50.8	COG1651@1|root,COG1651@2|Bacteria,1RFF4@1224|Proteobacteria,2U5BN@28211|Alphaproteobacteria,4B74W@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	COG1651 Protein-disulfide isomerase	MA20_42440	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
k59_1844102_1	502025.Hoch_2211	1.54e-22	96.3	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,43BX1@68525|delta/epsilon subdivisions,2X77U@28221|Deltaproteobacteria,2YTZ8@29|Myxococcales	28221|Deltaproteobacteria	Q	Phytoene dehydrogenase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
k59_1844102_2	502025.Hoch_2210	4.99e-30	118.0	COG0142@1|root,COG0142@2|Bacteria,1NXYK@1224|Proteobacteria,430UK@68525|delta/epsilon subdivisions,2WVY1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Belongs to the FPP GGPP synthase family	-	-	-	-	-	-	-	-	-	-	-	-	polyprenyl_synt
k59_1129989_1	1286106.MPL1_01677	1.91e-71	229.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,1RPBT@1236|Gammaproteobacteria,460BE@72273|Thiotrichales	72273|Thiotrichales	EGP	major facilitator superfamily	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
k59_1129989_2	870187.Thini_3645	1.9e-35	131.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,4601D@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_1489157_1	765912.Thimo_0459	4.43e-116	346.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1WVZP@135613|Chromatiales	135613|Chromatiales	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_1426535_1	1240349.ANGC01000006_gene1518	1.34e-21	90.1	COG3087@1|root,COG3087@2|Bacteria,2I5E1@201174|Actinobacteria	201174|Actinobacteria	D	Interferon-induced transmembrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CD225
k59_1844115_1	1125863.JAFN01000001_gene1554	8.17e-15	77.4	COG1357@1|root,COG1357@2|Bacteria,1N7U9@1224|Proteobacteria,42UJ1@68525|delta/epsilon subdivisions,2WR2I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,Pentapeptide
k59_663077_1	59374.Fisuc_1882	0.000232	43.5	COG3604@1|root,COG3604@2|Bacteria	2|Bacteria	KT	transcription factor binding	anfA	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
k59_663077_2	562970.Btus_3255	7.46e-09	58.9	COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,4HC6W@91061|Bacilli,278FR@186823|Alicyclobacillaceae	91061|Bacilli	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
k59_1366988_1	314278.NB231_01154	2.21e-08	59.7	COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,1WY02@135613|Chromatiales	135613|Chromatiales	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
k59_721697_1	1127696.HMPREF9134_00388	7.55e-66	224.0	COG0458@1|root,COG0458@2|Bacteria,4NEQ0@976|Bacteroidetes,2FMKD@200643|Bacteroidia,22W4Y@171551|Porphyromonadaceae	976|Bacteroidetes	EF	Carbamoyl-phosphate synthase (glutamine-hydrolyzing)	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,CPSase_sm_chain,GATase,MGS
k59_1080275_2	95619.PM1_0225755	1.57e-52	167.0	COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,1S4YE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	pilus assembly protein, PilZ	pilZ	-	-	ko:K02676	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilZ
k59_603531_1	795359.TOPB45_0772	3.84e-26	101.0	COG0200@1|root,COG0200@2|Bacteria,2GHVD@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
k59_603531_2	443144.GM21_3308	1.49e-35	132.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2WIZ7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_1718836_3	187272.Mlg_1326	2.02e-53	171.0	COG1376@1|root,COG1376@2|Bacteria,1RHBG@1224|Proteobacteria,1S6DY@1236|Gammaproteobacteria,1X25T@135613|Chromatiales	135613|Chromatiales	S	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_1844123_1	96561.Dole_1728	1.95e-08	55.8	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,42MY7@68525|delta/epsilon subdivisions,2WJH7@28221|Deltaproteobacteria,2MIBN@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1988	QRPTase_C,QRPTase_N
k59_1844123_2	880072.Desac_1415	3.08e-215	625.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,2MQ5P@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_427627_1	1198232.CYCME_0410	4.77e-107	320.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,4600D@72273|Thiotrichales	72273|Thiotrichales	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_963783_1	235985.BBPN01000042_gene8507	4.08e-06	53.9	COG4221@1|root,COG4221@2|Bacteria,2GMGQ@201174|Actinobacteria,2NGWH@228398|Streptacidiphilus	201174|Actinobacteria	S	KR domain	sdh_2	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1080280_1	1219375.CM002139_gene1958	3.14e-26	103.0	COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,1RMKJ@1236|Gammaproteobacteria,1X32G@135614|Xanthomonadales	135614|Xanthomonadales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1080280_2	203122.Sde_2165	4.03e-58	192.0	COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,1RMZ2@1236|Gammaproteobacteria,4640R@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	Belongs to the ParA family	fleN	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	ParA
k59_663089_1	1254432.SCE1572_29745	9.91e-85	277.0	COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,1R66T@1224|Proteobacteria,438GV@68525|delta/epsilon subdivisions,2X3RP@28221|Deltaproteobacteria,2YWY2@29|Myxococcales	28221|Deltaproteobacteria	P	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1542919_1	880073.Calab_3664	7.46e-37	137.0	COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,2NNYX@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	fabZ	GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0019171	3.5.1.108,4.2.1.59	ko:K02372,ko:K02535,ko:K13599,ko:K16363	ko00061,ko00540,ko00780,ko01100,ko01212,ko02020,map00061,map00540,map00780,map01100,map01212,map02020	M00060,M00083,M00498,M00572	R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965,R07764,R10117,R10121	RC00166,RC00300,RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005,ko02022	-	-	-	FabA,LpxC
k59_838861_2	1123504.JQKD01000019_gene5509	5.24e-05	48.9	COG2207@1|root,COG2207@2|Bacteria,1RAXA@1224|Proteobacteria,2W32I@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_1191565_1	1232437.KL661988_gene190	1.48e-78	247.0	COG3303@1|root,COG3303@2|Bacteria,1QX6Q@1224|Proteobacteria,42MHA@68525|delta/epsilon subdivisions,2WMF3@28221|Deltaproteobacteria,2MK9F@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1
k59_663093_1	76114.ebA3006	6.85e-74	232.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2VJBW@28216|Betaproteobacteria,2KU85@206389|Rhodocyclales	206389|Rhodocyclales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_134824_1	765912.Thimo_0894	3.33e-93	291.0	28MTB@1|root,2ZB1J@2|Bacteria,1MWD0@1224|Proteobacteria,1RSK4@1236|Gammaproteobacteria,1WVV5@135613|Chromatiales	135613|Chromatiales	S	PFAM Type IV conjugative transfer system protein TraH	-	-	-	ko:K12072	-	-	-	-	ko00000,ko02044	3.A.7.11.1	-	-	TraH
k59_134824_2	765913.ThidrDRAFT_1124	2.66e-30	120.0	COG4678@1|root,COG4678@2|Bacteria,1MXCR@1224|Proteobacteria,1RPZR@1236|Gammaproteobacteria,1WW1Z@135613|Chromatiales	135613|Chromatiales	G	PFAM TraG-like protein, N-terminal region	-	-	-	ko:K12056	-	-	-	-	ko00000,ko02044	3.A.7.11.1	-	-	TraG_N
k59_486402_1	446471.Xcel_2560	5.11e-108	315.0	COG1898@1|root,COG1898@2|Bacteria,2GMW4@201174|Actinobacteria,4F3ZC@85017|Promicromonosporaceae	201174|Actinobacteria	M	dTDP-4-dehydrorhamnose 3,5-epimerase	rmlC	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008830,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3465	dTDP_sugar_isom
k59_1198961_1	713587.THITH_04050	1.5e-57	194.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1WW79@135613|Chromatiales	135613|Chromatiales	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
k59_1198961_2	388399.SSE37_16848	1.87e-21	87.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2UFM1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	grxC	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
k59_1198961_3	765912.Thimo_1749	3.6e-102	312.0	28KIA@1|root,2ZA3I@2|Bacteria,1MXIF@1224|Proteobacteria,1RMA6@1236|Gammaproteobacteria,1WX53@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1855946_2	236097.ADG881_3215	8.71e-31	112.0	COG1320@1|root,COG1320@2|Bacteria,1MZ6Z@1224|Proteobacteria,1S8TM@1236|Gammaproteobacteria,1XKF2@135619|Oceanospirillales	135619|Oceanospirillales	P	Na H antiporter	phaG	-	-	ko:K05564	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	PhaG_MnhG_YufB
k59_388088_1	335543.Sfum_1859	5.45e-46	167.0	28HUW@1|root,2Z81F@2|Bacteria,1Q3QA@1224|Proteobacteria,42Q50@68525|delta/epsilon subdivisions,2WJN7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_388090_1	195105.CN97_11610	7.05e-05	46.6	COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2TR59@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_388090_2	1123237.Salmuc_00337	4.33e-48	154.0	COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,2U7TH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	IS66 Orf2 family protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k59_94581_1	391615.ABSJ01000035_gene1009	3.39e-120	380.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1J4ZQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1327685_1	631362.Thi970DRAFT_01518	1.77e-70	230.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1WWUA@135613|Chromatiales	135613|Chromatiales	M	Lytic murein transglycosylase B	-	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
k59_1607959_1	349521.HCH_04640	3.95e-32	119.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1S5PP@1236|Gammaproteobacteria,1XRB8@135619|Oceanospirillales	135619|Oceanospirillales	T	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_1549811_1	717606.PaecuDRAFT_1679	4.93e-51	184.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
k59_610988_1	765914.ThisiDRAFT_0758	4.25e-66	214.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1WVW6@135613|Chromatiales	135613|Chromatiales	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_610988_2	1097668.BYI23_B013750	4.64e-10	60.1	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2VQ97@28216|Betaproteobacteria,1K0GM@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM VacJ family lipoprotein	vacJ	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
k59_1434040_1	1121405.dsmv_2563	1.45e-90	279.0	COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,42MB6@68525|delta/epsilon subdivisions,2WJMI@28221|Deltaproteobacteria,2MIMT@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Acetyl-CoA hydrolase transferase	ato-2	-	2.8.3.18,3.1.2.1	ko:K01067,ko:K18118	ko00020,ko00620,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00650,map01100,map01110,map01120,map01130,map01200	M00009,M00011	R00227,R10343	RC00004,RC00012,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1125	AcetylCoA_hyd_C,AcetylCoA_hydro
k59_846157_1	1380354.JIAN01000007_gene308	1.03e-19	87.0	COG0671@1|root,COG0671@2|Bacteria,2HXWM@201174|Actinobacteria,4F1CW@85016|Cellulomonadaceae	201174|Actinobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
k59_434929_1	177437.HRM2_15160	1.08e-92	296.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,2MMPS@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	actB	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_552339_1	519989.ECTPHS_07242	4.2e-142	415.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales	135613|Chromatiales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_916446_1	1283300.ATXB01000001_gene1951	2.46e-96	299.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1XDV1@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_141958_1	471853.Bcav_2509	1.51e-56	187.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_141958_2	1125718.HMPREF1318_2604	1.16e-44	157.0	COG0739@1|root,COG0739@2|Bacteria,2IQ64@201174|Actinobacteria,4D66C@85005|Actinomycetales	201174|Actinobacteria	M	Peptidase, M23 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1018513_1	1410638.JHXJ01000017_gene581	7.65e-26	107.0	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia,3WGEN@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1549832_1	706587.Desti_3691	1.61e-71	223.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42N2W@68525|delta/epsilon subdivisions,2WJRB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_1199003_1	1121406.JAEX01000002_gene1021	2.43e-51	181.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,42N86@68525|delta/epsilon subdivisions,2WIV4@28221|Deltaproteobacteria,2M96K@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_272174_1	686340.Metal_3282	4.63e-86	259.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,1RRVZ@1236|Gammaproteobacteria,1XEBI@135618|Methylococcales	135618|Methylococcales	S	Belongs to the BI1 family	-	-	-	ko:K19416	-	M00742	-	-	ko00000,ko00002,ko02000	1.A.14.2.1	-	-	Bax1-I
k59_1327740_1	1232437.KL662077_gene1861	4.16e-23	95.5	2ARUS@1|root,31H6C@2|Bacteria,1RFAK@1224|Proteobacteria,42RXP@68525|delta/epsilon subdivisions,2WNXF@28221|Deltaproteobacteria,2MK37@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Type I restriction enzyme R protein N terminus (HSDR_N)	-	-	-	-	-	-	-	-	-	-	-	-	HSDR_N_2
k59_552351_1	1410624.JNKK01000024_gene1268	1.38e-33	125.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,24HMC@186801|Clostridia,27MET@186928|unclassified Lachnospiraceae	186801|Clostridia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
k59_1608001_1	1249627.D779_1826	2.11e-60	208.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WXV4@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_1018530_1	1260251.SPISAL_06785	5e-88	283.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_200540_1	1125863.JAFN01000001_gene248	4.06e-40	139.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QXM@68525|delta/epsilon subdivisions,2WMZI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_200540_2	768671.ThimaDRAFT_3966	3.99e-21	92.0	COG2825@1|root,COG2825@2|Bacteria,1PSPQ@1224|Proteobacteria,1SWU6@1236|Gammaproteobacteria,1WYG7@135613|Chromatiales	135613|Chromatiales	M	PFAM Outer membrane	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
k59_141979_1	1463825.JNXC01000005_gene2504	1.27e-16	89.7	COG2909@1|root,COG2909@2|Bacteria,2GJXF@201174|Actinobacteria,4DYUD@85010|Pseudonocardiales	201174|Actinobacteria	K	luxR family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
k59_94682_1	1049564.TevJSym_av00160	7.22e-131	387.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,1RQ7G@1236|Gammaproteobacteria,1J4EK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	COG0008 Glutamyl- and glutaminyl-tRNA synthetases	glnS	GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECIAI39_1322.ECIAI39_0637	tRNA-synt_1c,tRNA-synt_1c_C
k59_1199030_1	1463853.JOHW01000043_gene1649	6.87e-80	261.0	COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria	201174|Actinobacteria	P	part of an ABC transporter complex. Responsible for energy coupling to the transport system	-	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,ECF_trnsprt
k59_1856076_1	1286631.X805_09250	3.32e-55	192.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2VHYQ@28216|Betaproteobacteria,1KJAA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Vitamin B12 dependent methionine synthase activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_1136976_1	298654.FraEuI1c_3720	2.8e-11	67.8	COG0451@1|root,COG0451@2|Bacteria,2GP01@201174|Actinobacteria,4EUNR@85013|Frankiales	201174|Actinobacteria	GM	epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_1136976_2	1123065.ATWL01000004_gene2771	6.06e-13	74.3	2DD1M@1|root,2ZG5Q@2|Bacteria,2IFGU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1608014_1	879212.DespoDRAFT_01781	9.47e-50	177.0	COG0457@1|root,COG0457@2|Bacteria,1R64F@1224|Proteobacteria,42Q6D@68525|delta/epsilon subdivisions,2WKT0@28221|Deltaproteobacteria,2MHV1@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388
k59_1199033_1	572477.Alvin_0824	1.96e-74	233.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria,1WWFI@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_317992_1	765911.Thivi_2607	1.1e-91	280.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,1WWET@135613|Chromatiales	135613|Chromatiales	E	PFAM Aminotransferase class I and II	-	-	2.6.1.17	ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1373978_1	398767.Glov_0246	4.31e-82	263.0	COG0488@1|root,COG0488@2|Bacteria,1QUVR@1224|Proteobacteria,42P66@68525|delta/epsilon subdivisions,2WJ2D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_1784281_1	998674.ATTE01000001_gene2777	6.46e-44	163.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,45ZPW@72273|Thiotrichales	72273|Thiotrichales	P	heavy metal translocating P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_1327803_1	999541.bgla_2g08920	1.44e-20	99.8	COG2207@1|root,COG2207@2|Bacteria,1R4MG@1224|Proteobacteria,2VISE@28216|Betaproteobacteria,1KFIE@119060|Burkholderiaceae	28216|Betaproteobacteria	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_1373981_1	930171.Asphe3_22030	9.44e-05	52.0	COG2801@1|root,COG2801@2|Bacteria,2I8Z0@201174|Actinobacteria	201174|Actinobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_38882_1	395019.Bmul_0259	3.44e-70	214.0	COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,2VR2N@28216|Betaproteobacteria,1K6YJ@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
k59_1327822_1	768671.ThimaDRAFT_2775	1.62e-112	332.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1WWX5@135613|Chromatiales	135613|Chromatiales	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_846228_1	522306.CAP2UW1_1751	3.62e-126	363.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_975623_1	765912.Thimo_2960	1.17e-90	269.0	COG1051@1|root,COG1051@2|Bacteria,1RC3I@1224|Proteobacteria,1S34Y@1236|Gammaproteobacteria,1WY35@135613|Chromatiales	135613|Chromatiales	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_611076_1	981085.XP_010100462.1	0.000889	42.4	COG0604@1|root,KOG1198@2759|Eukaryota,37RRG@33090|Viridiplantae,3GC21@35493|Streptophyta,4JNIP@91835|fabids	35493|Streptophyta	C	Zinc-binding dehydrogenase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009579,GO:0009628,GO:0009941,GO:0010319,GO:0016491,GO:0016627,GO:0016628,GO:0031967,GO:0031975,GO:0035671,GO:0035798,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0048046,GO:0050896,GO:0055114	1.3.1.105	ko:K18980	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
k59_846233_1	497964.CfE428DRAFT_1773	2.85e-22	100.0	COG2197@1|root,COG4585@1|root,COG2197@2|Bacteria,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	ko:K07693,ko:K20971	ko02020,ko02025,map02020,map02025	M00479	-	-	ko00000,ko00001,ko00002,ko01001,ko02022	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA_3,MASE1,Response_reg
k59_1199062_1	159087.Daro_2801	1.21e-69	236.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,2KVY2@206389|Rhodocyclales	206389|Rhodocyclales	P	AcrB/AcrD/AcrF family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
k59_1856132_1	545264.KB898744_gene2255	3.21e-89	276.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1WVYR@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_1018569_1	870187.Thini_0482	5.78e-158	459.0	COG1100@1|root,COG1100@2|Bacteria,1R1W9@1224|Proteobacteria,1SK3H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF697,MMR_HSR1
k59_1784306_1	335543.Sfum_2077	2.99e-82	260.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42P0M@68525|delta/epsilon subdivisions,2WJMC@28221|Deltaproteobacteria,2MR1W@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	AMP-dependent synthetase and ligase	-	-	6.2.1.1,6.2.1.32	ko:K01895,ko:K08295	ko00010,ko00620,ko00627,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00627,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R00982,R01354	RC00004,RC00012,RC00043,RC00070,RC00174,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_388279_1	1123228.AUIH01000024_gene3255	1.61e-35	134.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1XH4H@135619|Oceanospirillales	135619|Oceanospirillales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1668976_1	1123392.AQWL01000001_gene1447	7.33e-163	466.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,2VH4U@28216|Betaproteobacteria,1KS6G@119069|Hydrogenophilales	119069|Hydrogenophilales	E	lysine 2,3-aminomutase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_611087_1	523791.Kkor_0378	8.08e-32	121.0	COG1878@1|root,COG1878@2|Bacteria	2|Bacteria	S	arylformamidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
k59_728770_1	319224.Sputcn32_0014	2.98e-57	194.0	COG0006@1|root,COG0006@2|Bacteria,1MURT@1224|Proteobacteria,1RMKT@1236|Gammaproteobacteria,2Q948@267890|Shewanellaceae	1236|Gammaproteobacteria	E	Splits dipeptides with a prolyl residue in the C- terminal position	pepQ	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009056,GO:0009987,GO:0016787,GO:0016805,GO:0019538,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0070573,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_1199067_1	1380354.JIAN01000007_gene181	1.94e-31	118.0	COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria,4F15R@85016|Cellulomonadaceae	201174|Actinobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
k59_1199067_2	1123065.ATWL01000002_gene1672	2.22e-61	189.0	2AFXT@1|root,3161G@2|Bacteria,2IKPZ@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF2469)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2469
k59_846245_1	938289.CAJN020000007_gene220	4.03e-70	229.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,267NF@186813|unclassified Clostridiales	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
k59_1264323_1	335543.Sfum_1603	7.77e-86	257.0	COG2344@1|root,COG2344@2|Bacteria,1R55V@1224|Proteobacteria,42M2S@68525|delta/epsilon subdivisions,2WM6N@28221|Deltaproteobacteria,2MQEC@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
k59_1264323_2	96561.Dole_0631	8.18e-17	74.3	COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,42VAI@68525|delta/epsilon subdivisions,2WRI4@28221|Deltaproteobacteria,2MKRV@213118|Desulfobacterales	28221|Deltaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_918060_1	164328.Phyra85044	5.34e-36	139.0	COG0043@1|root,2QR5I@2759|Eukaryota,3QHUS@4776|Peronosporales	4776|Peronosporales	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.102	ko:K20039	ko00940,map00940	-	R02952,R03367	RC00814	ko00000,ko00001,ko01000	-	-	-	UbiD
k59_96287_1	506534.Rhein_0404	1.17e-81	253.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,1RPNJ@1236|Gammaproteobacteria,1X2E3@135613|Chromatiales	135613|Chromatiales	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1329358_4	472759.Nhal_2555	1.58e-42	150.0	29XIV@1|root,30J9U@2|Bacteria,1NN8G@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_671083_1	1120970.AUBZ01000012_gene1916	1.23e-67	231.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,46AE7@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	GXGXG motif	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_389760_1	1443111.JASG01000004_gene1165	5.78e-39	141.0	COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,2U1U3@28211|Alphaproteobacteria,3ZWCK@60136|Sulfitobacter	28211|Alphaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_142861_1	477641.MODMU_5259	2.12e-94	302.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,2GM65@201174|Actinobacteria,4ERFQ@85013|Frankiales	201174|Actinobacteria	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016853,GO:0016866,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0047727,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	5.4.99.13,5.4.99.2	ko:K01848,ko:K11942	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_318886_1	314278.NB231_09828	5.14e-34	133.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,1RQBI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_918080_1	62928.azo3792	1.09e-63	202.0	COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,2VJ4W@28216|Betaproteobacteria,2KWD1@206389|Rhodocyclales	206389|Rhodocyclales	C	Hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
k59_918080_2	1276756.AUEX01000021_gene3333	6.99e-15	68.9	COG0298@1|root,COG0298@2|Bacteria,1PWB0@1224|Proteobacteria,2VWYW@28216|Betaproteobacteria,4AIEF@80864|Comamonadaceae	28216|Betaproteobacteria	O	HupF/HypC family	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
k59_611933_1	1158345.JNLL01000001_gene76	2.84e-80	262.0	COG1048@1|root,COG1048@2|Bacteria,2G3S7@200783|Aquificae	200783|Aquificae	C	TIGRFAM aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_1329377_1	2340.JV46_25840	8.95e-137	411.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1J526@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_435858_1	391595.RLO149_c037000	7.3e-06	48.5	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_435858_2	767434.Fraau_2421	3.64e-06	52.8	COG0745@1|root,COG0784@1|root,COG2203@1|root,COG5002@1|root,COG5278@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,COG5278@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,1XDBG@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Response_reg
k59_435858_3	1300345.LF41_2215	1.33e-15	75.9	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1X6K6@135614|Xanthomonadales	135614|Xanthomonadales	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1264341_1	278957.ABEA03000173_gene2451	2.05e-84	264.0	COG2204@1|root,COG2204@2|Bacteria,46SFE@74201|Verrucomicrobia,3K7NF@414999|Opitutae	414999|Opitutae	T	sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_389783_1	882086.SacxiDRAFT_2846	5.95e-128	396.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4E0QS@85010|Pseudonocardiales	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	ctpF	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.8	ko:K01537,ko:K12953	-	-	-	-	ko00000,ko01000	3.A.3,3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_560049_2	765911.Thivi_2069	6.25e-112	331.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1WWX5@135613|Chromatiales	135613|Chromatiales	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_442801_1	367299.JOEE01000009_gene245	9.55e-28	103.0	COG3304@1|root,COG3304@2|Bacteria,2IKS5@201174|Actinobacteria,4FH4Z@85021|Intrasporangiaceae	201174|Actinobacteria	S	Inner membrane component domain	yccF	-	-	-	-	-	-	-	-	-	-	-	YccF
k59_442801_2	1210046.B277_06108	2.08e-101	310.0	COG2308@1|root,COG2308@2|Bacteria,2GN0J@201174|Actinobacteria,4FF5D@85021|Intrasporangiaceae	201174|Actinobacteria	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_1,CP_ATPgrasp_2
k59_50122_2	631362.Thi970DRAFT_02379	2.45e-13	71.6	COG2367@1|root,COG2367@2|Bacteria,1R7HB@1224|Proteobacteria,1S1BH@1236|Gammaproteobacteria,1WWWC@135613|Chromatiales	135613|Chromatiales	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
k59_1790940_1	1049564.TevJSym_ad00260	2.72e-50	174.0	COG1008@1|root,COG1008@2|Bacteria,1R8V8@1224|Proteobacteria,1RZVG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	overlaps another CDS with the same product name	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_149988_1	590998.Celf_3212	9.57e-29	114.0	COG1819@1|root,COG1819@2|Bacteria	2|Bacteria	CG	transferase activity, transferring hexosyl groups	alg2	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,UDPGT
k59_149988_2	1227349.C170_13605	4.7e-23	102.0	COG1541@1|root,COG1541@2|Bacteria,1UYWT@1239|Firmicutes,4HD2R@91061|Bacilli,26TM3@186822|Paenibacillaceae	91061|Bacilli	H	Coenzyme F390 synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
k59_1506774_1	95619.PM1_0229070	1.08e-20	87.8	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iSF_1195.SF3815,iSFxv_1172.SFxv_4157,iS_1188.S3953	OSCP
k59_1506774_2	93220.LV28_14120	1.13e-45	160.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2VHQU@28216|Betaproteobacteria,1K1JD@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_990219_1	1172179.AUKV01000003_gene7464	1.05e-81	271.0	COG1020@1|root,COG1028@1|root,COG3321@1|root,COG3882@1|root,COG1020@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,COG3882@2|Bacteria,2GISR@201174|Actinobacteria	201174|Actinobacteria	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
k59_443670_1	765911.Thivi_2181	4.8e-50	174.0	COG1199@1|root,COG1199@2|Bacteria,1QW37@1224|Proteobacteria,1T2R3@1236|Gammaproteobacteria,1X2NJ@135613|Chromatiales	135613|Chromatiales	KL	ATP-dependent helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_443670_2	697282.Mettu_0192	1.7e-30	117.0	29SM0@1|root,30DSB@2|Bacteria,1RFFC@1224|Proteobacteria,1T0JT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF4239)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4239
k59_1207508_1	999423.HMPREF9161_00870	2.67e-12	68.6	COG1774@1|root,COG1774@2|Bacteria,1TP1V@1239|Firmicutes,4H2TJ@909932|Negativicutes	909932|Negativicutes	S	PSP1 C-terminal domain protein	yaaT	-	-	-	-	-	-	-	-	-	-	-	PSP1
k59_619527_1	177437.HRM2_44130	1.87e-68	224.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,42Q8R@68525|delta/epsilon subdivisions,2WMDK@28221|Deltaproteobacteria,2MJEG@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Trimethylamine methyltransferase	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
k59_1616783_1	1267535.KB906767_gene3764	1.61e-60	201.0	COG0477@1|root,COG2814@2|Bacteria,3Y9FM@57723|Acidobacteria,2JP7Y@204432|Acidobacteriia	2|Bacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
k59_619528_1	1123072.AUDH01000014_gene1303	3.89e-36	139.0	COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,2U1SX@28211|Alphaproteobacteria,2JRJ2@204441|Rhodospirillales	204441|Rhodospirillales	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_1870674_1	762963.HMPREF9056_01849	8.66e-111	340.0	COG1640@1|root,COG1640@2|Bacteria,2GM5Z@201174|Actinobacteria,4D33D@85005|Actinomycetales	201174|Actinobacteria	G	4-alpha-glucanotransferase	malQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_109142_1	352165.HMPREF7215_2259	3.72e-39	144.0	COG0628@1|root,COG0628@2|Bacteria,3T9W6@508458|Synergistetes	508458|Synergistetes	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1207512_1	1249627.D779_1245	5.61e-111	345.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1870676_1	1123073.KB899242_gene1159	1.85e-36	141.0	COG3209@1|root,COG3386@1|root,COG3391@1|root,COG3209@2|Bacteria,COG3386@2|Bacteria,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,1SZ73@1236|Gammaproteobacteria	1224|Proteobacteria	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
k59_209357_1	344747.PM8797T_27954	4e-49	173.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,PRiA4_ORF3,zf-IS66
k59_502305_1	396588.Tgr7_0360	5.37e-210	590.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1WW3A@135613|Chromatiales	135613|Chromatiales	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
k59_1677669_1	1123392.AQWL01000008_gene1238	3.46e-87	275.0	COG3292@1|root,COG3292@2|Bacteria,1QMJ4@1224|Proteobacteria,2VNHI@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
k59_1870684_1	1049564.TevJSym_ao00230	7.44e-08	58.5	COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,1SYTB@1236|Gammaproteobacteria,1J7DI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_402660_1	324057.Pjdr2_4791	5.33e-09	57.4	COG3584@1|root,COG3584@2|Bacteria,1UYMN@1239|Firmicutes,4HIVQ@91061|Bacilli,26YD8@186822|Paenibacillaceae	91061|Bacilli	S	3D domain	yuiC	-	-	-	-	-	-	-	-	-	-	-	3D
k59_1677673_1	1463845.JOIG01000007_gene531	6.27e-37	134.0	COG0623@1|root,COG0623@2|Bacteria,2GJ65@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	inhA	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_560928_1	713586.KB900536_gene617	5.98e-100	296.0	COG3000@1|root,COG3000@2|Bacteria,1NR7X@1224|Proteobacteria,1RQDX@1236|Gammaproteobacteria,1X1MB@135613|Chromatiales	135613|Chromatiales	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_790712_1	1123377.AUIV01000015_gene202	2.66e-35	146.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1X4Z1@135614|Xanthomonadales	135614|Xanthomonadales	G	phosphomannomutase	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1507711_1	292415.Tbd_1426	9.25e-61	197.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2VHWA@28216|Betaproteobacteria,1KSTF@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Sodium Bile acid symporter family	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
k59_1507711_2	663610.JQKO01000021_gene322	1.38e-38	138.0	COG0394@1|root,COG1393@1|root,COG0394@2|Bacteria,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,2U70U@28211|Alphaproteobacteria,3NB3X@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	ArsC family	arsC	-	1.20.4.1	ko:K00537,ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
k59_679188_1	1134445.AJJM01000066_gene3748	2.09e-31	125.0	COG1482@1|root,COG1482@2|Bacteria,2GJXC@201174|Actinobacteria	201174|Actinobacteria	G	mannose-6-phosphate isomerase	manA	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
k59_1616794_1	545276.KB898724_gene1884	8.16e-20	90.9	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RY2M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,GGDEF,PAS_9,Response_reg
k59_1616794_2	1415780.JPOG01000001_gene954	6.68e-65	198.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,1S5ZK@1236|Gammaproteobacteria,1X6V9@135614|Xanthomonadales	135614|Xanthomonadales	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	VM57_07835	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4
k59_1098883_1	78898.MVEG_03153T0	3.08e-67	229.0	COG0265@1|root,KOG1421@2759|Eukaryota,39J7H@33154|Opisthokonta,3P060@4751|Fungi,1GSR9@112252|Fungi incertae sedis	4751|Fungi	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_1,Trypsin_2
k59_443697_1	367299.JOEE01000008_gene454	1.49e-78	253.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4FEP0@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA ligase	ligD	-	-	-	-	-	-	-	-	-	-	-	DNA_primase_S
k59_560937_1	713587.THITH_00820	2.74e-114	350.0	COG1205@1|root,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,1S0XD@1236|Gammaproteobacteria,1WXNC@135613|Chromatiales	135613|Chromatiales	L	DEAD DEAH box	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
k59_1616803_1	1499967.BAYZ01000095_gene4075	1.95e-39	137.0	COG2220@1|root,COG2220@2|Bacteria,2NQD1@2323|unclassified Bacteria	2|Bacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
k59_1144418_1	264732.Moth_1887	2.43e-82	261.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,42EM7@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding	nuoF	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_737840_1	1415166.NONO_c60570	6.17e-36	135.0	COG4641@1|root,COG4641@2|Bacteria,2H1Z7@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2
k59_737840_2	861047.E0YPE1_9CAUD	3.68e-47	170.0	4QE90@10239|Viruses,4QW9R@35237|dsDNA viruses  no RNA stage,4QSPY@28883|Caudovirales,4QMGW@10699|Siphoviridae	10699|Siphoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_737840_3	365528.KB891219_gene817	3.6e-11	66.2	2EH1V@1|root,33ATU@2|Bacteria,2GU12@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_990280_1	1283284.AZUK01000001_gene1526	1.55e-13	75.9	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1Y3NC@135624|Aeromonadales	135624|Aeromonadales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_1870717_1	1035308.AQYY01000002_gene417	1.5e-58	201.0	COG1263@1|root,COG1264@1|root,COG2190@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,COG2190@2|Bacteria,1TP5X@1239|Firmicutes,247WT@186801|Clostridia	186801|Clostridia	G	Pts system	-	-	-	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	M00271	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6	-	-	PTS_EIIA_1,PTS_EIIB,PTS_EIIC
k59_502328_1	713587.THITH_15555	8.03e-19	94.7	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales	135613|Chromatiales	P	PFAM TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_1734961_1	1469245.JFBG01000059_gene2418	1.49e-76	234.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1WWUP@135613|Chromatiales	135613|Chromatiales	V	PFAM N-acetylmuramoyl-L-alanine amidase family 2	-	-	3.5.1.28	ko:K03806	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	Amidase_2
k59_283961_1	886379.AEWI01000005_gene909	7.18e-82	271.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,4NFRF@976|Bacteroidetes,2FMI7@200643|Bacteroidia,3XJS4@558415|Marinilabiliaceae	976|Bacteroidetes	E	B12 binding domain	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_502329_1	686340.Metal_3463	8.54e-112	341.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1XE7N@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_109197_1	981369.JQMJ01000004_gene377	4.43e-38	137.0	COG2135@1|root,COG2135@2|Bacteria,2GKY8@201174|Actinobacteria,2NHRP@228398|Streptacidiphilus	201174|Actinobacteria	S	SOS response associated peptidase (SRAP)	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
k59_1677703_1	765911.Thivi_3330	7.86e-57	187.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,1WWVS@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
k59_737861_1	237609.PSAKL28_44850	3.78e-95	283.0	COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,1RNUA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,IstB_IS21_ATP
k59_1025679_1	765911.Thivi_2388	2.05e-38	136.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,1WVYQ@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
k59_1025679_2	322710.Avin_47720	2.67e-14	72.4	COG3159@1|root,COG3159@2|Bacteria,1RD7B@1224|Proteobacteria,1S539@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09921	-	-	-	-	ko00000	-	-	-	DUF484
k59_1507752_1	43354.JOIJ01000018_gene4792	0.00018	49.3	COG0318@1|root,COG0318@2|Bacteria,2GN9C@201174|Actinobacteria,4DYFK@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	menE	GO:0003674,GO:0003824,GO:0008150,GO:0008756,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0040007	4.2.1.113,6.2.1.26	ko:K01911,ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030,R04031	RC00004,RC00014,RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_1382816_1	1123073.KB899241_gene2699	1.36e-122	363.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RN5B@1236|Gammaproteobacteria,1X32P@135614|Xanthomonadales	135614|Xanthomonadales	E	aminotransferase	-	-	2.6.1.2,2.6.1.66	ko:K14260	ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230	-	R00258,R01215	RC00006,RC00008,RC00036	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_990312_1	1496688.ER33_14805	5.42e-76	246.0	COG5361@1|root,COG5361@2|Bacteria,1G1YW@1117|Cyanobacteria,22TKK@167375|Cyanobium	1117|Cyanobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_150957_1	289376.THEYE_A0112	2.31e-81	252.0	COG0192@1|root,COG0192@2|Bacteria,3J0A4@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_51282_1	28444.JODQ01000014_gene6701	0.000269	44.3	2DZ3S@1|root,34CBX@2|Bacteria,2GX0A@201174|Actinobacteria,4EKZ4@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF4229)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4229
k59_109223_1	754476.Q7A_2017	1.09e-38	139.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,460BA@72273|Thiotrichales	72273|Thiotrichales	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_109223_2	1500893.JQNB01000001_gene3186	1.83e-16	77.8	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1X3CE@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_931133_1	590998.Celf_2509	9.2e-84	271.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	wgeG	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Radical_SAM,SPASM
k59_1144452_2	314278.NB231_13251	1.4e-52	175.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1RCFZ@1224|Proteobacteria,1S2QS@1236|Gammaproteobacteria,1X1B9@135613|Chromatiales	135613|Chromatiales	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_150964_1	439497.RR11_1812	6.4e-19	86.7	COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,2TSRR@28211|Alphaproteobacteria,4NB0W@97050|Ruegeria	28211|Alphaproteobacteria	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs	dusA	-	-	ko:K05539	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_150964_2	395494.Galf_1902	5.37e-85	259.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2VP54@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_990329_1	1402135.SUH3_08280	7.54e-51	172.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2U2G6@28211|Alphaproteobacteria,3ZZ8R@60136|Sulfitobacter	28211|Alphaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_402774_1	1049564.TevJSym_au00010	1.51e-40	155.0	COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,1J8QI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
k59_790766_1	159450.NH14_17795	5.28e-06	47.8	COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,2VJIQ@28216|Betaproteobacteria,1K4RW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA polymerase	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
k59_790766_2	1283300.ATXB01000001_gene1279	6.38e-26	100.0	2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SHAU@1236|Gammaproteobacteria,1XFBV@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_209439_2	765912.Thimo_1549	7.36e-94	286.0	COG0475@1|root,COG0475@2|Bacteria,1MVGV@1224|Proteobacteria,1RQFR@1236|Gammaproteobacteria,1WZGI@135613|Chromatiales	135613|Chromatiales	P	PFAM sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_443753_2	471853.Bcav_2913	1.62e-57	190.0	COG2239@1|root,COG2239@2|Bacteria,2GMMK@201174|Actinobacteria	201174|Actinobacteria	P	transporter mgtE	mgtE	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE_N,PRC
k59_1098944_1	1123258.AQXZ01000011_gene1636	1.34e-53	180.0	COG0079@1|root,COG0079@2|Bacteria,2GJXS@201174|Actinobacteria,4FVSN@85025|Nocardiaceae	201174|Actinobacteria	E	May catalyze the transamination reaction in phenylalanine biosynthesis	pat	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_209440_1	983917.RGE_12180	2.51e-22	94.4	2C3PP@1|root,2Z954@2|Bacteria,1MXGR@1224|Proteobacteria	1224|Proteobacteria	S	Branched-chain amino acid aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_209440_2	512565.AMIS_46440	2.37e-22	94.0	COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria,4DF2K@85008|Micromonosporales	201174|Actinobacteria	EH	Amino-transferase class IV	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_1207594_2	519989.ECTPHS_00110	1.19e-48	164.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1WWMV@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_1735017_1	413404.Rmag_0859	4.55e-34	127.0	COG5557@1|root,COG5557@2|Bacteria,1MXP7@1224|Proteobacteria,1SMKH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_1735017_2	396588.Tgr7_2195	4.58e-50	165.0	COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,1RRYZ@1236|Gammaproteobacteria,1WVZM@135613|Chromatiales	135613|Chromatiales	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_7
k59_284016_1	1476583.DEIPH_ctg046orf0051	2.49e-31	127.0	COG2217@1|root,COG2217@2|Bacteria,1WJ55@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	pacS	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_284017_1	1108045.GORHZ_053_00540	1.11e-89	276.0	COG0471@1|root,COG0471@2|Bacteria,2GVHZ@201174|Actinobacteria,4GD1J@85026|Gordoniaceae	201174|Actinobacteria	P	Sodium:sulfate symporter transmembrane region	sdcS	-	-	ko:K03319,ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47,2.A.47.1	-	-	Na_sulph_symp
k59_737901_1	34506.g2356	7.96e-28	114.0	COG0294@1|root,COG1109@1|root,KOG1220@2759|Eukaryota,KOG2544@2759|Eukaryota,38WEB@33154|Opisthokonta,3C72M@33208|Metazoa,3DRE6@33213|Bilateria,40P6G@6231|Nematoda,1M6NG@119089|Chromadorea,4152Z@6236|Rhabditida	33208|Metazoa	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II	-	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
k59_737901_2	257310.BB4836	1.19e-15	77.8	290UJ@1|root,2ZNGJ@2|Bacteria,1RBSP@1224|Proteobacteria,2VZ0V@28216|Betaproteobacteria,3T5CZ@506|Alcaligenaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_51313_1	1125973.JNLC01000012_gene888	3.29e-07	61.6	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,1QUUA@1224|Proteobacteria,2U1P5@28211|Alphaproteobacteria,3JXT9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_1,Glycos_transf_2
k59_1558630_2	391615.ABSJ01000027_gene167	3.83e-23	98.2	2E29H@1|root,32X6D@2|Bacteria,1QZRZ@1224|Proteobacteria,1T4AF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Acetoacetate decarboxylase (ADC)	-	-	-	-	-	-	-	-	-	-	-	-	ADC
k59_1273439_1	882.DVU_1223	4.59e-57	191.0	COG1944@1|root,COG1944@2|Bacteria,1N5NV@1224|Proteobacteria,42P09@68525|delta/epsilon subdivisions,2WK3G@28221|Deltaproteobacteria,2M8SK@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	-	-	-	-	-	-	-	-	-	YcaO
k59_679299_1	1429046.RR21198_0947	1.14e-64	207.0	COG0169@1|root,COG0169@2|Bacteria,2GPXV@201174|Actinobacteria,4FWSX@85025|Nocardiaceae	201174|Actinobacteria	E	Shikimate dehydrogenase substrate binding domain	-	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_dh_N
k59_209466_2	979556.MTES_2215	2.69e-134	382.0	COG0235@1|root,COG0235@2|Bacteria,2GNI6@201174|Actinobacteria,4FK64@85023|Microbacteriaceae	201174|Actinobacteria	G	Class II Aldolase and Adducin N-terminal domain	araD	-	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
k59_1690866_1	765910.MARPU_07535	9.6e-93	285.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WWGD@135613|Chromatiales	135613|Chromatiales	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1455931_1	709032.Sulku_0866	1.3e-24	95.9	2AIYH@1|root,31ARU@2|Bacteria,1Q60N@1224|Proteobacteria,42WN0@68525|delta/epsilon subdivisions,2YQ8T@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Domain of unknown function (DUF2018)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2018
k59_1220583_1	335543.Sfum_3891	1.39e-58	183.0	COG2033@1|root,COG2033@2|Bacteria,1RHE0@1224|Proteobacteria,42SB9@68525|delta/epsilon subdivisions,2WP2D@28221|Deltaproteobacteria,2MQFR@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Desulfoferrodoxin, ferrous iron-binding	dfx	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
k59_1395592_1	1502850.FG91_02393	1.87e-89	279.0	COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,2U119@28211|Alphaproteobacteria,2K1J9@204457|Sphingomonadales	204457|Sphingomonadales	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_1455954_1	446471.Xcel_1938	2.19e-68	228.0	COG0370@1|root,COG0370@2|Bacteria,2GTV2@201174|Actinobacteria	201174|Actinobacteria	P	Ferrous iron transport protein B	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoA,FeoB_C,FeoB_N,Gate
k59_1629897_1	479435.Kfla_4891	3.31e-14	67.0	COG1977@1|root,COG1977@2|Bacteria,2GQM9@201174|Actinobacteria,4DW7X@85009|Propionibacteriales	201174|Actinobacteria	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
k59_1629897_2	768671.ThimaDRAFT_0622	1.9e-132	397.0	COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,1RQWX@1236|Gammaproteobacteria,1WZGU@135613|Chromatiales	135613|Chromatiales	C	PFAM Glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_1522847_1	880072.Desac_2671	4.33e-111	335.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2WKBU@28221|Deltaproteobacteria,2MQ6I@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035,ko:K13893	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
k59_514781_1	1408418.JNJH01000068_gene1671	3.42e-35	125.0	COG2142@1|root,COG2142@2|Bacteria,1MZND@1224|Proteobacteria,2UC3G@28211|Alphaproteobacteria,2JTFI@204441|Rhodospirillales	204441|Rhodospirillales	C	Succinate dehydrogenase, hydrophobic anchor subunit	sdhD	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_1522848_1	933262.AXAM01000015_gene101	2.44e-125	373.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42MZJ@68525|delta/epsilon subdivisions,2WJK1@28221|Deltaproteobacteria,2MIBC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_164021_1	1298863.AUEP01000009_gene26	5e-73	225.0	COG0500@1|root,COG2226@2|Bacteria,2GJSF@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_164021_2	446471.Xcel_3283	4.41e-07	47.4	2EG2Y@1|root,339UX@2|Bacteria,2GZG7@201174|Actinobacteria,4F5VJ@85017|Promicromonosporaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_164023_1	936136.ARRT01000006_gene5425	1.3e-18	89.0	COG3735@1|root,COG3735@2|Bacteria,1RBFT@1224|Proteobacteria,2U5YM@28211|Alphaproteobacteria,4BNMU@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	TraB family	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
k59_1802908_1	446466.Cfla_1449	3.6e-30	115.0	COG2116@1|root,COG2116@2|Bacteria,2I8DX@201174|Actinobacteria	201174|Actinobacteria	P	Formate nitrite transporter	-	-	-	-	-	-	-	-	-	-	-	-	Form_Nir_trans
k59_340130_1	1297865.APJD01000035_gene5472	2.66e-65	223.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,3JR5K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Penicillin-binding Protein	pbpC	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
k59_514792_1	2340.JV46_24290	5.09e-45	155.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1J9VF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Hydrogenase formation hypA family	hypD	GO:0003674,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0036211,GO:0042165,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070025,GO:0071704,GO:1901564	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
k59_514792_2	883.DvMF_2355	7.15e-17	83.2	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2WJ51@28221|Deltaproteobacteria,2M8IT@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	iAF987.Gmet_0119	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_1522868_1	1713.JOFV01000019_gene1114	1.59e-168	479.0	COG0667@1|root,COG0667@2|Bacteria,2GMT5@201174|Actinobacteria,4F1VU@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM aldo keto reductase	-	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
k59_868291_1	398527.Bphyt_3380	3.08e-94	300.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,1K2G2@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1220631_3	768671.ThimaDRAFT_4448	1.16e-51	187.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1WWT9@135613|Chromatiales	1236|Gammaproteobacteria	O	Belongs to the ClpA ClpB family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
k59_1522877_1	870187.Thini_2438	3.23e-102	315.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,463PR@72273|Thiotrichales	72273|Thiotrichales	S	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_1629921_1	999550.KI421507_gene2351	1.45e-05	51.6	COG3735@1|root,COG3735@2|Bacteria,1R7DV@1224|Proteobacteria,2U24S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
k59_1629921_2	323848.Nmul_A0354	1.8e-108	323.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,372UE@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_1114044_1	1499680.CCFE01000021_gene2183	4.61e-41	152.0	COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,4H9QK@91061|Bacilli,1ZDI2@1386|Bacillus	91061|Bacilli	H	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
k59_514797_1	1249627.D779_1465	5.93e-63	194.0	COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,1S4YE@1236|Gammaproteobacteria,1WYAQ@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type IV pilus assembly PilZ	-	-	-	ko:K02676	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilZ
k59_1690930_1	1713.JOFV01000010_gene1132	1.97e-53	184.0	COG4585@1|root,COG4585@2|Bacteria,2GJ4J@201174|Actinobacteria,4F1VF@85016|Cellulomonadaceae	201174|Actinobacteria	T	ATP-binding region ATPase domain protein	tcsS3	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,PspC
k59_691938_1	1089551.KE386572_gene744	1.18e-19	90.1	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VFBT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_1040534_1	93220.LV28_00675	9.61e-90	273.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,1K25Z@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Phosphate transporter	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_1802929_1	670307.HYPDE_22768	2.99e-50	180.0	COG0744@1|root,COG0744@2|Bacteria	2|Bacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mrcB	-	2.4.1.129,3.4.16.4	ko:K03814,ko:K05365,ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
k59_1748207_1	543632.JOJL01000012_gene6673	5.66e-26	100.0	COG1917@1|root,COG1917@2|Bacteria,2IRRU@201174|Actinobacteria,4DJUR@85008|Micromonosporales	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1395653_1	338969.Rfer_4072	1.09e-14	75.5	COG4635@1|root,COG4635@2|Bacteria,1RAH2@1224|Proteobacteria,2VSTC@28216|Betaproteobacteria,4AHVS@80864|Comamonadaceae	28216|Betaproteobacteria	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
k59_1114063_1	765913.ThidrDRAFT_3481	3.68e-17	77.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,1S5YQ@1236|Gammaproteobacteria,1WYJN@135613|Chromatiales	135613|Chromatiales	J	PFAM Class I peptide chain release factor	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
k59_1114063_2	765912.Thimo_2701	1.53e-57	181.0	COG1403@1|root,COG1403@2|Bacteria,1RGZQ@1224|Proteobacteria,1S5V4@1236|Gammaproteobacteria,1WYBY@135613|Chromatiales	135613|Chromatiales	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH
k59_1395655_2	665571.STHERM_c10970	5.05e-24	105.0	COG0539@1|root,COG0539@2|Bacteria,2J5DZ@203691|Spirochaetes	203691|Spirochaetes	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Cytidylate_kin,S1
k59_1155967_1	314345.SPV1_01352	4.14e-47	168.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria	1224|Proteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1802936_1	1172186.KB911465_gene4361	6.01e-46	167.0	COG1020@1|root,COG1020@2|Bacteria,2GKGU@201174|Actinobacteria,23632@1762|Mycobacteriaceae	201174|Actinobacteria	Q	Wax ester synthase-like Acyl-CoA acyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
k59_341324_1	382245.ASA_2543	4.59e-10	65.1	COG2207@1|root,COG2207@2|Bacteria,1RHJ6@1224|Proteobacteria,1SBSY@1236|Gammaproteobacteria,1Y5MZ@135624|Aeromonadales	135624|Aeromonadales	K	Transcriptional regulator, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_693180_1	395493.BegalDRAFT_3049	1.43e-54	193.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,45ZYC@72273|Thiotrichales	72273|Thiotrichales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_1157052_1	1031711.RSPO_c02458	2.89e-94	301.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2VJ5Q@28216|Betaproteobacteria,1K0UC@119060|Burkholderiaceae	28216|Betaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1042367_1	350054.Mflv_3909	3.34e-59	190.0	COG0350@1|root,COG0350@2|Bacteria,2GKA9@201174|Actinobacteria,236MH@1762|Mycobacteriaceae	201174|Actinobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
k59_693210_1	647113.Metok_0537	3.43e-88	275.0	COG0439@1|root,arCOG01590@2157|Archaea,2Y8CM@28890|Euryarchaeota,23QDY@183939|Methanococci	183939|Methanococci	I	TIGRFAM acetyl-CoA carboxylase, biotin carboxylase	pycA	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_869771_1	1510531.JQJJ01000014_gene4709	2.83e-103	308.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,3JU2P@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	ivd2	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1290635_1	1117314.PCIT_13169	1.61e-42	159.0	COG3568@1|root,COG3568@2|Bacteria,1R3X8@1224|Proteobacteria,1RZYH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
k59_1631399_1	471853.Bcav_3511	5.5e-91	276.0	COG0258@1|root,COG0258@2|Bacteria,2GKTZ@201174|Actinobacteria	201174|Actinobacteria	L	5'-3' exonuclease	polA_1	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
k59_1290638_1	935839.JAGJ01000003_gene1557	6.02e-46	167.0	COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria,4F48B@85017|Promicromonosporaceae	201174|Actinobacteria	L	DSHCT	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
k59_1749338_1	1442599.JAAN01000005_gene1016	3.84e-41	149.0	COG0644@1|root,COG0644@2|Bacteria,1MZVI@1224|Proteobacteria,1RMNS@1236|Gammaproteobacteria,1X4V2@135614|Xanthomonadales	135614|Xanthomonadales	C	COG0644 Dehydrogenases (flavoproteins)	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
k59_869779_1	870187.Thini_1634	7.49e-82	250.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,463SA@72273|Thiotrichales	72273|Thiotrichales	L	DDE domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_1749345_1	1713.JOFV01000005_gene2311	3.76e-16	78.2	COG5401@1|root,COG5401@2|Bacteria,2IMZD@201174|Actinobacteria,4F1FV@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	AMIN
k59_223660_1	765911.Thivi_1955	4.3e-36	129.0	COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,1S7VQ@1236|Gammaproteobacteria,1WZ09@135613|Chromatiales	135613|Chromatiales	O	Glutathione S-transferase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_N_3
k59_1222003_1	631362.Thi970DRAFT_04435	4.24e-84	262.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RS8H@1236|Gammaproteobacteria,1WWVZ@135613|Chromatiales	135613|Chromatiales	C	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_1457426_1	1249627.D779_4054	2.45e-119	360.0	COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria,1S06C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Alkaline phosphatase	pafA	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
k59_574618_1	743720.Psefu_3966	2.64e-17	80.9	2E3XG@1|root,32YUI@2|Bacteria,1N8RF@1224|Proteobacteria,1SCJ3@1236|Gammaproteobacteria,1YYX6@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second- messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
k59_574618_2	1035839.AFNK01000071_gene681	6.97e-32	123.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1Y6QU@135625|Pasteurellales	135625|Pasteurellales	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI
k59_1457432_1	530564.Psta_1613	2.37e-59	188.0	COG0783@1|root,COG0783@2|Bacteria,2IZJP@203682|Planctomycetes	203682|Planctomycetes	P	Belongs to the Dps family	-	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
k59_869819_2	177439.DP2329	6.05e-15	74.3	COG4067@1|root,COG4067@2|Bacteria,1N0VV@1224|Proteobacteria,43B1S@68525|delta/epsilon subdivisions	1224|Proteobacteria	O	Putative ATP-dependant zinc protease	-	-	-	-	-	-	-	-	-	-	-	-	Zn_protease
k59_1042430_1	1121875.KB907546_gene2238	1.92e-84	258.0	COG1409@1|root,COG1409@2|Bacteria,4NFAP@976|Bacteroidetes,1I2DE@117743|Flavobacteriia	976|Bacteroidetes	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,PA14
k59_693264_1	987059.RBXJA2T_12477	1.08e-40	146.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2VIXG@28216|Betaproteobacteria,1KJ4K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_341415_1	1150399.AQYK01000002_gene3097	1.08e-71	234.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4FN4H@85023|Microbacteriaceae	201174|Actinobacteria	P	STAS domain	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_574630_1	1380387.JADM01000006_gene1137	9.5e-63	214.0	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,1XHAM@135619|Oceanospirillales	135619|Oceanospirillales	I	Belongs to the GPAT DAPAT family	plsB	-	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_341417_1	1442599.JAAN01000020_gene2554	1.44e-58	206.0	COG0841@1|root,COG0845@1|root,COG0841@2|Bacteria,COG0845@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X3PQ@135614|Xanthomonadales	135614|Xanthomonadales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	mdtB	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_1397021_2	935840.JAEQ01000007_gene3957	3.93e-16	78.2	COG3740@1|root,COG3740@2|Bacteria,1QVIJ@1224|Proteobacteria,2TVIM@28211|Alphaproteobacteria,43N07@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Caudovirus prohead serine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S78,Phage_capsid
k59_752546_1	396588.Tgr7_1460	2.64e-87	275.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1WW9D@135613|Chromatiales	135613|Chromatiales	L	single-stranded-DNA-specific exonuclease RecJ	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_1290691_1	439235.Dalk_2784	2.6e-42	145.0	COG2050@1|root,COG2050@2|Bacteria,1N61W@1224|Proteobacteria,42U4S@68525|delta/epsilon subdivisions,2WQWD@28221|Deltaproteobacteria,2MKZU@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
k59_223694_1	384765.SIAM614_28117	1.07e-81	251.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2TT4V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_801721_1	1304865.JAGF01000001_gene3071	1.17e-13	69.7	COG0518@1|root,COG0518@2|Bacteria,2GNA6@201174|Actinobacteria	201174|Actinobacteria	F	glutamine amidotransferase	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,Methyltransf_11
k59_801721_2	266940.Krad_1231	3.65e-81	254.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2GNDC@201174|Actinobacteria	201174|Actinobacteria	F	IMP dehydrogenase GMP reductase	guaB1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
k59_341426_1	1229780.BN381_150079	4.38e-34	120.0	COG0251@1|root,COG0251@2|Bacteria,2IFCR@201174|Actinobacteria,3UXBZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
k59_341426_2	452637.Oter_4323	1.11e-08	57.4	COG3797@1|root,COG3797@2|Bacteria,46WV6@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
k59_801722_1	446469.Sked_01730	4.82e-13	68.9	COG0561@1|root,COG0561@2|Bacteria,2GP42@201174|Actinobacteria	201174|Actinobacteria	J	hydrolase	yidA	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
k59_801726_1	933262.AXAM01000031_gene3006	1.63e-73	230.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,42MND@68525|delta/epsilon subdivisions,2WJC3@28221|Deltaproteobacteria,2MIG5@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Bacterial transferase hexapeptide (six repeats)	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
k59_574646_1	1121015.N789_01130	1.25e-135	394.0	COG0687@1|root,COG0687@2|Bacteria,1NKD7@1224|Proteobacteria,1RQPF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Spermidine putrescine ABC transporter substrate-binding protein	ydcS	GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008152,GO:0009058,GO:0009290,GO:0009292,GO:0009294,GO:0009987,GO:0015931,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042618,GO:0042619,GO:0044464,GO:0044764,GO:0050657,GO:0051027,GO:0051179,GO:0051234,GO:0051704,GO:0071702,GO:0071704,GO:0071705,GO:0098657,GO:1901440,GO:1901441,GO:1901576	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	iECNA114_1301.ECNA114_1576,iECSF_1327.ECSF_1364,iEcHS_1320.EcHS_A1524	SBP_bac_8
k59_1692372_1	998674.ATTE01000001_gene1726	3.58e-37	132.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins	iscR	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
k59_1692372_2	748658.KB907314_gene146	8.06e-77	230.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,1WW3I@135613|Chromatiales	135613|Chromatiales	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
k59_1692372_3	105559.Nwat_0957	8.79e-28	109.0	COG1985@1|root,COG1985@2|Bacteria,1RDMT@1224|Proteobacteria,1S4SQ@1236|Gammaproteobacteria,1X05Z@135613|Chromatiales	135613|Chromatiales	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_457316_1	765913.ThidrDRAFT_3396	1.34e-68	218.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,1RN90@1236|Gammaproteobacteria,1WW7R@135613|Chromatiales	135613|Chromatiales	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
k59_752589_1	1265505.ATUG01000003_gene123	2.2e-71	224.0	COG0289@1|root,COG0289@2|Bacteria,1QB39@1224|Proteobacteria,42NRC@68525|delta/epsilon subdivisions,2WJGM@28221|Deltaproteobacteria,2MJ2I@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the DapB family	-	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
k59_1692396_2	1120950.KB892820_gene721	2.93e-07	50.1	COG3945@1|root,COG3945@2|Bacteria,2I92G@201174|Actinobacteria,4DS57@85009|Propionibacteriales	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red,Hemerythrin
k59_801749_1	1415779.JOMH01000001_gene176	9.84e-80	248.0	COG2304@1|root,COG2304@2|Bacteria,1QBPM@1224|Proteobacteria,1RQIU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Secreted protein, containing von Willebrand factor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_574665_1	706587.Desti_2892	1.41e-82	263.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_574665_2	439235.Dalk_3804	2.85e-31	116.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42NI5@68525|delta/epsilon subdivisions,2WIN8@28221|Deltaproteobacteria,2MPXX@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_223752_1	1121033.AUCF01000053_gene3999	2.6e-184	521.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,2JPZG@204441|Rhodospirillales	204441|Rhodospirillales	L	Transposase mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1646241_1	765911.Thivi_1855	3.59e-107	336.0	COG1328@1|root,COG1372@1|root,COG1328@2|Bacteria,COG1372@2|Bacteria,1MWMS@1224|Proteobacteria,1RNHS@1236|Gammaproteobacteria,1X2DE@135613|Chromatiales	135613|Chromatiales	F	Ribonucleoside-triphosphate reductase	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,LAGLIDADG_3,NRDD
k59_62311_1	330214.NIDE2587	8.57e-88	286.0	COG1643@1|root,COG1643@2|Bacteria	2|Bacteria	L	helicase activity	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_1763305_2	398767.Glov_1317	2.15e-29	116.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,42P6I@68525|delta/epsilon subdivisions,2WMAF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
k59_648065_1	545695.TREAZ_2473	5.72e-05	44.3	COG0792@1|root,COG0792@2|Bacteria,2J8CV@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
k59_648065_2	754476.Q7A_999	1.19e-13	73.9	COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,460M8@72273|Thiotrichales	72273|Thiotrichales	M	LppC putative lipoprotein	-	-	-	ko:K07121	-	-	-	-	ko00000	-	-	-	LppC
k59_530690_1	545264.KB898750_gene207	2.53e-77	253.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1763307_1	1121405.dsmv_0116	8.32e-64	198.0	COG0426@1|root,COG0426@2|Bacteria,1RKK1@1224|Proteobacteria,42RRR@68525|delta/epsilon subdivisions,2WP60@28221|Deltaproteobacteria,2MK3X@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5
k59_1411218_1	405948.SACE_5073	5.28e-124	365.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4E9CU@85010|Pseudonocardiales	201174|Actinobacteria	L	Transposase	tnp3508a	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_1587106_2	1122201.AUAZ01000003_gene1873	7.79e-95	284.0	28JRZ@1|root,2Z9HI@2|Bacteria,1R52Z@1224|Proteobacteria,1RRWN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126,SHOCT
k59_62323_1	555779.Dthio_PD2002	5.59e-08	60.1	COG2304@1|root,COG2885@1|root,COG2304@2|Bacteria,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,42R0I@68525|delta/epsilon subdivisions,2WN29@28221|Deltaproteobacteria,2MGS4@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA,VWA_2
k59_178435_1	196162.Noca_4468	9.63e-71	224.0	COG0650@1|root,COG0650@2|Bacteria,2GJFM@201174|Actinobacteria,4DT2Y@85009|Propionibacteriales	201174|Actinobacteria	C	NADH dehydrogenase	hycD	-	-	ko:K12138	-	-	-	-	ko00000,ko01000	-	-	-	NADHdh
k59_237512_1	1089545.KB913037_gene3398	1e-93	289.0	COG1061@1|root,COG1061@2|Bacteria,2H66X@201174|Actinobacteria	201174|Actinobacteria	KL	Type III restriction enzyme res subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1411224_1	367299.JOEE01000008_gene383	2.55e-118	370.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4FEK0@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the DNA polymerase type-C family. DnaE2 subfamily	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_355810_1	631362.Thi970DRAFT_01611	2.85e-89	279.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1WWDG@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_765275_1	713587.THITH_08780	9.86e-100	302.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,1WVZU@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_884223_1	1348338.ADILRU_0601	6.51e-41	151.0	COG1178@1|root,COG1178@2|Bacteria,2GKPT@201174|Actinobacteria,4FK9A@85023|Microbacteriaceae	201174|Actinobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_884223_2	1122182.KB903814_gene3615	1.11e-13	70.9	COG1840@1|root,COG1840@2|Bacteria,2IIYM@201174|Actinobacteria,4D8Y6@85008|Micromonosporales	201174|Actinobacteria	P	Bacterial extracellular solute-binding protein	afuA	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_11,SBP_bac_6
k59_1352502_1	933262.AXAM01000034_gene1557	1.78e-141	418.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2MIPH@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_62345_2	1289387.AUKW01000003_gene2353	4.77e-05	43.5	COG0230@1|root,COG0230@2|Bacteria,2GQFY@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
k59_942951_1	367299.JOEE01000004_gene1341	7.88e-134	414.0	COG1643@1|root,COG1643@2|Bacteria,2GIWX@201174|Actinobacteria,4FEPI@85021|Intrasporangiaceae	201174|Actinobacteria	L	ATP-dependent helicase	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_1528488_1	1202962.KB907150_gene1689	8.51e-24	94.7	COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,1S682@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	TLL0138	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
k59_648089_2	1312959.KI914633_gene1861	2.32e-15	73.6	2EHCF@1|root,33B4A@2|Bacteria,2HTCM@201174|Actinobacteria,1WAAR@1268|Micrococcaceae	201174|Actinobacteria	S	Protein of unknown function (DUF4244)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4244
k59_648089_3	1380354.JIAN01000005_gene1570	5.85e-09	55.1	2EGB2@1|root,33A2X@2|Bacteria,2HXXD@201174|Actinobacteria,4F1IE@85016|Cellulomonadaceae	201174|Actinobacteria	S	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
k59_62346_1	243233.MCA1213	9.49e-80	255.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,1SZW9@1236|Gammaproteobacteria,1XFPE@135618|Methylococcales	135618|Methylococcales	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
k59_1352511_1	1035308.AQYY01000002_gene1015	1.31e-80	261.0	COG3973@1|root,COG3973@2|Bacteria,1TP39@1239|Firmicutes,249IG@186801|Clostridia,26003@186807|Peptococcaceae	186801|Clostridia	L	Helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_19,UvrD-helicase,UvrD_C,UvrD_C_2
k59_1704784_1	1206744.BAGL01000070_gene5237	1.1e-61	201.0	COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria,4G5XM@85025|Nocardiaceae	201174|Actinobacteria	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HHH_5,Helicase_C,SNF2_N
k59_942959_1	1385935.N836_00985	0.000756	48.1	COG0840@1|root,COG0840@2|Bacteria,1G07J@1117|Cyanobacteria,1HF64@1150|Oscillatoriales	1117|Cyanobacteria	NT	methyl-accepting chemotaxis	-	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	GAF,HAMP,MCPsignal,MHYT,PAS_9,Phosphonate-bd,dCache_1
k59_1117561_1	177437.HRM2_01330	9.42e-19	78.6	COG0610@1|root,COG0610@2|Bacteria	2|Bacteria	L	Subunit R is required for both nuclease and ATPase activities, but not for modification	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
k59_1117561_2	331678.Cphamn1_2542	4.61e-64	202.0	COG1451@1|root,COG1451@2|Bacteria	2|Bacteria	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
k59_1411245_1	1255043.TVNIR_0253	5.94e-81	250.0	COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,1WWM6@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator	-	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
k59_178461_1	948106.AWZT01000020_gene4127	1.17e-22	95.9	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VHZU@28216|Betaproteobacteria,1K0EZ@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_178461_2	745310.G432_17480	1.43e-05	48.5	COG1226@1|root,COG1226@2|Bacteria,1MXQP@1224|Proteobacteria,2TTRN@28211|Alphaproteobacteria,2K11P@204457|Sphingomonadales	204457|Sphingomonadales	P	COG1226 Kef-type K transport systems	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
k59_1646282_1	343509.SG2366	8.23e-05	45.1	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_4275,iECH74115_1262.ECH74115_5243,iECIAI1_1343.ECIAI1_3991,iECO103_1326.ECO103_4362,iECO111_1330.ECO111_4628,iECO26_1355.ECO26_4784,iECSE_1348.ECSE_4086,iEKO11_1354.EKO11_4554,iPC815.YPO3849	Porphobil_deam,Porphobil_deamC
k59_1646282_2	1158146.KB907121_gene1179	6.89e-33	123.0	COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria,1WWAM@135613|Chromatiales	135613|Chromatiales	H	Uroporphyrinogen III synthase	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
k59_1823411_1	471853.Bcav_1922	4.5e-197	565.0	COG0187@1|root,COG0187@2|Bacteria,2GM1E@201174|Actinobacteria	201174|Actinobacteria	L	DNA topoisomerase (ATP-hydrolyzing)	gyrB2	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_648099_1	1123368.AUIS01000003_gene1674	7.67e-137	397.0	COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,1RP7G@1236|Gammaproteobacteria,2NBSY@225057|Acidithiobacillales	225057|Acidithiobacillales	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
k59_1528503_2	981369.JQMJ01000004_gene5593	9.31e-20	87.8	COG0821@1|root,COG0821@2|Bacteria,2GK2S@201174|Actinobacteria,2NEPT@228398|Streptacidiphilus	201174|Actinobacteria	I	GcpE protein	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_1235205_1	994479.GL877878_gene3560	7.52e-67	207.0	COG0490@1|root,COG0490@2|Bacteria,2IFBQ@201174|Actinobacteria,4E3CX@85010|Pseudonocardiales	201174|Actinobacteria	P	regulatory ligand binding protein, C-terminal domain of K channels like protein	-	-	-	ko:K07228	-	-	-	-	ko00000	-	-	-	TrkA_C
k59_706880_1	1214065.BAGV01000052_gene1708	5.08e-08	60.1	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,1RMMF@1236|Gammaproteobacteria,282KZ@191675|unclassified Enterobacteriaceae	1236|Gammaproteobacteria	S	TamB, inner membrane protein subunit of TAM complex	ytfN	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0097347	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
k59_355862_1	1123073.KB899241_gene2336	2.23e-09	56.6	COG2839@1|root,COG2839@2|Bacteria,1MZEV@1224|Proteobacteria,1SAFY@1236|Gammaproteobacteria,1X6YB@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	ko:K09793	-	-	-	-	ko00000	-	-	-	DUF456
k59_355862_2	2340.JV46_19800	4.77e-57	186.0	COG1796@1|root,COG1796@2|Bacteria,1QF8Z@1224|Proteobacteria,1RRQ5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Helix-hairpin-helix domain	-	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	HHH_5,HHH_8
k59_413171_2	1179773.BN6_60300	3.66e-69	218.0	COG0394@1|root,COG0640@1|root,COG0394@2|Bacteria,COG0640@2|Bacteria,2IB1N@201174|Actinobacteria,4E6RW@85010|Pseudonocardiales	201174|Actinobacteria	KT	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,LMWPc
k59_62382_1	1000565.METUNv1_03446	1.98e-46	169.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2VI5J@28216|Betaproteobacteria,2KWW5@206389|Rhodocyclales	206389|Rhodocyclales	M	AsmA family	-	-	-	-	-	-	-	-	-	-	-	-	AsmA
k59_1823425_1	156889.Mmc1_3476	1.94e-08	54.3	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,2U71I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
k59_1235206_1	580332.Slit_0817	9.09e-78	244.0	COG1638@1|root,COG1638@2|Bacteria,1PN6J@1224|Proteobacteria,2VSNQ@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1352529_1	998674.ATTE01000001_gene4315	4.4e-42	156.0	COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,460CJ@72273|Thiotrichales	72273|Thiotrichales	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,TPR_1,TPR_2,VWA_2
k59_3143_1	1089455.MOPEL_132_00380	1.55e-223	669.0	COG0110@1|root,COG1020@1|root,COG0110@2|Bacteria,COG1020@2|Bacteria,2I8TI@201174|Actinobacteria,4F7NP@85018|Dermatophilaceae	201174|Actinobacteria	Q	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Hexapep,Hexapep_2,PP-binding
k59_1704809_1	396588.Tgr7_3002	5.13e-40	147.0	COG0843@1|root,COG0843@2|Bacteria,1QJ23@1224|Proteobacteria,1SKBI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	-	-	-	-	-	-	-	-	-	-	COX1
k59_1352532_4	999541.bgla_2g27990	5.1e-18	82.4	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,1K22A@119060|Burkholderiaceae	28216|Betaproteobacteria	EQ	5-oxoprolinase	-	-	3.5.2.14,3.5.2.9	ko:K01469,ko:K01473	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00251,R03187	RC00553,RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_765301_1	590998.Celf_1128	3.33e-141	404.0	COG0788@1|root,COG0788@2|Bacteria,2GM0G@201174|Actinobacteria,4F10X@85016|Cellulomonadaceae	201174|Actinobacteria	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT,ACT_6,Formyl_trans_N
k59_765301_2	471853.Bcav_2992	2.2e-84	254.0	COG0454@1|root,COG0456@2|Bacteria,2GK6K@201174|Actinobacteria	201174|Actinobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
k59_765301_3	585198.HMPREF0574_1586	3.69e-05	45.8	COG0112@1|root,COG0112@2|Bacteria,2GK7U@201174|Actinobacteria,4D3IA@85005|Actinomycetales	201174|Actinobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006563,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009069,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019752,GO:0019842,GO:0020012,GO:0030170,GO:0030312,GO:0030682,GO:0036094,GO:0042133,GO:0042783,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044464,GO:0046983,GO:0048037,GO:0050662,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0071944,GO:0075136,GO:0097159,GO:1901363,GO:1901564,GO:1901605	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_648117_1	1123355.JHYO01000004_gene2487	8.68e-27	101.0	COG3784@1|root,COG3784@2|Bacteria,1Q09X@1224|Proteobacteria,2UIQS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1318
k59_1528521_1	1206743.BAGM01000208_gene250	2.12e-09	65.5	COG1080@1|root,COG1080@2|Bacteria,2I3CU@201174|Actinobacteria,4FZ3K@85025|Nocardiaceae	201174|Actinobacteria	G	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
k59_1235221_1	929704.Myrod_3428	1.55e-30	124.0	COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,4NEDY@976|Bacteroidetes,1HXFG@117743|Flavobacteriia	976|Bacteroidetes	HJM	cyanophycin synthetase	cphA	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M,RimK
k59_648122_1	1304885.AUEY01000040_gene1609	2.05e-35	127.0	COG2974@1|root,COG2974@2|Bacteria,1RCUH@1224|Proteobacteria,42QVW@68525|delta/epsilon subdivisions,2WN5B@28221|Deltaproteobacteria,2MJPM@213118|Desulfobacterales	28221|Deltaproteobacteria	L	May be involved in recombination	-	-	-	-	-	-	-	-	-	-	-	-	RdgC
k59_413193_1	1223545.GS4_08_02320	1.63e-07	53.9	COG3040@1|root,COG3040@2|Bacteria,2IJI0@201174|Actinobacteria,4GC5J@85026|Gordoniaceae	201174|Actinobacteria	M	Lipocalin-like domain	-	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
k59_413193_2	1123033.ARNF01000051_gene1036	3.51e-10	60.8	COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,1T0MZ@1236|Gammaproteobacteria,3NTGZ@468|Moraxellaceae	1236|Gammaproteobacteria	S	Predicted membrane protein (DUF2238)	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
k59_1295229_1	479431.Namu_2907	1.39e-50	164.0	COG3585@1|root,COG3585@2|Bacteria,2IKQV@201174|Actinobacteria,4ET46@85013|Frankiales	201174|Actinobacteria	H	DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,MerR,TOBE
k59_1295229_2	1449068.JMLQ01000008_gene3979	3.04e-39	140.0	COG0725@1|root,COG0725@2|Bacteria,2GMPF@201174|Actinobacteria,4FU1U@85025|Nocardiaceae	201174|Actinobacteria	P	Bacterial extracellular solute-binding protein	modA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0040007,GO:0042597,GO:0043167,GO:0043168,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
k59_1587169_1	882.DVU_1942	1.87e-67	231.0	COG1461@1|root,COG1461@2|Bacteria,1NKAM@1224|Proteobacteria,42U2G@68525|delta/epsilon subdivisions,2WQBG@28221|Deltaproteobacteria,2M8TG@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Dihydroxyacetone kinase family	-	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak2,DegV
k59_1764264_1	1415778.JQMM01000001_gene335	2.17e-139	408.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4KR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	prsR	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_590545_1	518766.Rmar_1468	1.38e-63	200.0	COG2050@1|root,COG2050@2|Bacteria,4NX1Y@976|Bacteroidetes,1FJMP@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	Q	Thioesterase superfamily	-	-	3.1.2.28	ko:K19222	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07262	RC00004,RC00174	ko00000,ko00001,ko00002,ko01000	-	-	-	4HBT
k59_414108_1	713586.KB900536_gene1367	3.51e-49	169.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1WXJ6@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_1470905_1	93220.LV28_18760	5.64e-114	336.0	COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2VIBJ@28216|Betaproteobacteria,1JZPC@119060|Burkholderiaceae	28216|Betaproteobacteria	K	LysR family	oxyR	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
k59_238573_1	1198452.Jab_1c21250	1.03e-61	214.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,475WI@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,CHASE8,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_7,PAS_9,Response_reg
k59_1529479_1	870187.Thini_0565	7.17e-51	168.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,46002@72273|Thiotrichales	1224|Proteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008137,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0050136,GO:0051179,GO:0051234,GO:0051536,GO:0051539,GO:0051540,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iYL1228.KPN_02677	Oxidored_q6
k59_1470906_1	105559.Nwat_0563	1.26e-142	410.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1WXDH@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_238574_1	1279017.AQYJ01000029_gene3815	4.07e-15	75.1	COG1566@1|root,COG1566@2|Bacteria,1MWG0@1224|Proteobacteria,1RRE3@1236|Gammaproteobacteria,467TC@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_238574_2	933262.AXAM01000109_gene2062	2.3e-14	73.6	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,2MJIJ@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1353562_1	456442.Mboo_1077	1.14e-46	159.0	arCOG05203@1|root,arCOG05203@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1470908_1	472759.Nhal_3687	2.35e-89	276.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1WW6G@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1060398_1	1033802.SSPSH_003346	8e-41	146.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RN5F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Malic enzyme	maeB	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
k59_1060398_2	1366050.N234_10995	2.51e-15	75.1	COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,2VH4M@28216|Betaproteobacteria,1K1VT@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	purT	-	2.1.2.2	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp,Epimerase
k59_1412306_1	1232683.ADIMK_0403	1.2e-179	541.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,464EF@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,iJN746.PP_1037,ic_1306.c3080	AIRS_C,GATase_5
k59_63903_1	1123355.JHYO01000034_gene563	2.07e-115	362.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,36XHA@31993|Methylocystaceae	28211|Alphaproteobacteria	P	AcrB/AcrD/AcrF family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_1353564_1	1267005.KB911259_gene3837	4.52e-144	422.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSK4@28211|Alphaproteobacteria,3N6IZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	MA20_26350	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1177459_1	43759.JNWK01000044_gene1559	4.86e-25	102.0	COG1309@1|root,COG1309@2|Bacteria,2IHQX@201174|Actinobacteria	201174|Actinobacteria	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
k59_894231_2	519989.ECTPHS_01759	5.09e-61	199.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1WX79@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
k59_1305424_1	497964.CfE428DRAFT_4093	2.45e-58	205.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,46SAP@74201|Verrucomicrobia	74201|Verrucomicrobia	CE	Proline dehydrogenase	-	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
k59_1418898_1	323261.Noc_0390	2.3e-77	242.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXE7@135613|Chromatiales	135613|Chromatiales	GM	NAD-dependent epimerase dehydratase	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
k59_1418898_2	754477.Q7C_1770	1.31e-42	156.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,463KB@72273|Thiotrichales	72273|Thiotrichales	M	PFAM Transglycosylase SLT domain	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
k59_1068770_1	405948.SACE_2155	3.33e-07	51.2	COG0363@1|root,COG0363@2|Bacteria,2GMQ2@201174|Actinobacteria,4DXRG@85010|Pseudonocardiales	201174|Actinobacteria	G	6-phosphogluconolactonase	pgl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:1901135,GO:1901360,GO:1901564	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
k59_1068770_2	59538.XP_005976334.1	1.75e-40	142.0	COG4122@1|root,KOG1663@2759|Eukaryota,39S6H@33154|Opisthokonta	33154|Opisthokonta	Q	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
k59_1653689_1	1232437.KL662008_gene3438	7.84e-34	130.0	COG4191@1|root,COG4191@2|Bacteria,1R682@1224|Proteobacteria,42P91@68525|delta/epsilon subdivisions,2WKQI@28221|Deltaproteobacteria,2MJEK@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9
k59_478997_1	367299.JOEE01000004_gene1095	1.42e-122	364.0	COG0111@1|root,COG0111@2|Bacteria,2GJGA@201174|Actinobacteria,4FE7W@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_894239_1	572477.Alvin_0839	2.5e-132	398.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1WXGJ@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_72521_1	446466.Cfla_1979	0.000462	44.7	2DNRF@1|root,32YSD@2|Bacteria,2IAJC@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_72521_2	313589.JNB_02700	7.01e-45	150.0	COG0009@1|root,COG0009@2|Bacteria,2GNEW@201174|Actinobacteria,4FF1Q@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the SUA5 family	-	-	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
k59_1006045_1	765914.ThisiDRAFT_0666	4.45e-204	602.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales	135613|Chromatiales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_596255_1	765912.Thimo_2601	1.22e-51	186.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1WXQJ@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_1535366_1	1123065.ATWL01000028_gene1963	3.64e-49	176.0	COG1403@1|root,COG1403@2|Bacteria,2GP2N@201174|Actinobacteria	201174|Actinobacteria	V	HNH endonuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_72535_1	395493.BegalDRAFT_2644	1.61e-109	329.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,46043@72273|Thiotrichales	72273|Thiotrichales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_537843_2	1041146.ATZB01000001_gene4637	3.96e-08	55.8	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2TSE3@28211|Alphaproteobacteria,4B9XT@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
k59_1535374_1	267608.RSc1353	1.91e-20	90.1	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VIEX@28216|Betaproteobacteria,1K005@119060|Burkholderiaceae	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	ilvG	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1535374_2	987059.RBXJA2T_14806	2.69e-29	114.0	COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,2VJSB@28216|Betaproteobacteria,1KNB9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Carboxylesterase family	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
k59_1480608_2	1123228.AUIH01000008_gene2354	2.14e-17	85.5	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,1RMSZ@1236|Gammaproteobacteria,1XJ26@135619|Oceanospirillales	135619|Oceanospirillales	EGP	Sugar (and other) transporter	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_128079_1	1108045.GORHZ_044_00010	5.53e-139	410.0	COG5421@1|root,COG5421@2|Bacteria,2GK2A@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1245544_1	426355.Mrad2831_0213	3.21e-17	86.3	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria,2VDSR@28211|Alphaproteobacteria,1JRF8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_7,Response_reg
k59_251076_1	322710.Avin_42990	1.68e-30	120.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	May be involved in recombinational repair of damaged DNA	recN	GO:0000724,GO:0000725,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
k59_251076_2	525244.HMPREF0023_3051	2.7e-36	132.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,3NIJZ@468|Moraxellaceae	1236|Gammaproteobacteria	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iEcSMS35_1347.EcSMS35_2767	NAD_kinase
k59_771824_1	879212.DespoDRAFT_03566	4.44e-84	266.0	COG4467@1|root,COG4467@2|Bacteria,1PPMF@1224|Proteobacteria	1224|Proteobacteria	S	Involved in initiation control of chromosome replication	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66
k59_17445_1	367299.JOEE01000005_gene3574	4.03e-145	415.0	COG0391@1|root,COG0391@2|Bacteria,2GJBW@201174|Actinobacteria,4FEGA@85021|Intrasporangiaceae	201174|Actinobacteria	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
k59_479865_1	1121405.dsmv_1683	1.09e-103	319.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,43BUE@68525|delta/epsilon subdivisions,2X75I@28221|Deltaproteobacteria,2MPKE@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Conserved carboxylase domain	oadA	-	2.1.3.1,4.1.1.3,6.4.1.1	ko:K01571,ko:K01960,ko:K03416	ko00020,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00640,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344,R00353,R00930	RC00040,RC00097,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_1480628_1	1156935.QWE_21107	2.99e-37	142.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2TRZC@28211|Alphaproteobacteria,4BB1X@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Putative nucleotidyltransferase substrate binding domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_597058_2	247634.GPB2148_14	1.33e-80	249.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria	1224|Proteobacteria	L	Transposase and inactivated derivatives	-	-	2.7.7.49	ko:K00986,ko:K07497	-	-	-	-	ko00000,ko01000	-	-	-	HTH_32,rve,rve_3
k59_538686_1	314345.SPV1_04928	2.3e-95	308.0	28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria	1224|Proteobacteria	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
k59_1360175_2	349521.HCH_01355	1.85e-29	107.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,1SCA2@1236|Gammaproteobacteria,1XM21@135619|Oceanospirillales	135619|Oceanospirillales	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	grxC	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
k59_1360175_3	742742.HMPREF9452_01921	2.03e-10	61.6	COG0607@1|root,COG0607@2|Bacteria,2HV5N@201174|Actinobacteria,4CWCQ@84998|Coriobacteriia	84998|Coriobacteriia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1360175_4	519989.ECTPHS_01334	1.17e-44	164.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1WX4I@135613|Chromatiales	135613|Chromatiales	D	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_128089_2	118173.KB235914_gene2652	1.73e-15	75.1	COG3900@1|root,COG3900@2|Bacteria,1G5FF@1117|Cyanobacteria,1HG0N@1150|Oscillatoriales	1117|Cyanobacteria	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
k59_656418_1	1082933.MEA186_07929	2.64e-126	369.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2TUZN@28211|Alphaproteobacteria,43IG1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	-	-	2.1.3.3,2.1.3.6	ko:K00611,ko:K13252	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_771837_1	393595.ABO_1895	2.11e-60	193.0	COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,1S24F@1236|Gammaproteobacteria,1XJAQ@135619|Oceanospirillales	135619|Oceanospirillales	S	Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
k59_251117_1	477228.YO5_16098	3.47e-48	162.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,1RN71@1236|Gammaproteobacteria,1Z1PC@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	P	COG0725 ABC-type molybdate transport system, periplasmic component	modA-2	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
k59_251117_2	187272.Mlg_1924	9.04e-17	77.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,1RRDV@1236|Gammaproteobacteria,1WWGA@135613|Chromatiales	135613|Chromatiales	P	TIGRFAM Molybdate ABC transporter	-	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
k59_1480642_1	1172188.KB911821_gene1614	2.53e-76	239.0	COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria,4FETI@85021|Intrasporangiaceae	201174|Actinobacteria	V	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_128097_1	644107.SL1157_A0025	2.28e-81	254.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2TQYQ@28211|Alphaproteobacteria,4NAMP@97050|Ruegeria	28211|Alphaproteobacteria	P	Phosphate transport system permease protein PstA	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
k59_17467_1	1306174.JODP01000001_gene5103	1.81e-101	336.0	COG1074@1|root,COG1074@2|Bacteria,2GNKH@201174|Actinobacteria	201174|Actinobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_73749_1	228410.NE1659	2.57e-129	379.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,2VMTY@28216|Betaproteobacteria,372DF@32003|Nitrosomonadales	28216|Betaproteobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	ko:K16291	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	YkuD
k59_73749_3	1121943.KB899992_gene2162	4.91e-11	60.8	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1S8WW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_1770753_1	1380354.JIAN01000008_gene3580	7.22e-142	408.0	COG0224@1|root,COG0224@2|Bacteria,2GJ7Q@201174|Actinobacteria,4F0M2@85016|Cellulomonadaceae	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_1712306_1	1279017.AQYJ01000027_gene1769	2.87e-08	55.5	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,463ZS@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Protein containing LysM domain	lysM	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_1712306_2	395019.Bmul_3125	1.54e-26	111.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,1K1PV@119060|Burkholderiaceae	28216|Betaproteobacteria	LU	DNA protecting protein DprA	smf	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_421060_1	1117318.PRUB_23966	3.12e-42	154.0	COG0651@1|root,COG1009@1|root,COG0651@2|Bacteria,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,2Q0AH@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	CP	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	-	-	-	ko:K05568,ko:K12139	-	-	-	-	ko00000,ko01000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
k59_1834885_1	582744.Msip34_0332	9.31e-21	98.2	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria,2KKZX@206350|Nitrosomonadales	206350|Nitrosomonadales	M	PFAM MscS Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_1006777_1	1380354.JIAN01000005_gene2915	7.73e-98	290.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4F0MX@85016|Cellulomonadaceae	201174|Actinobacteria	T	PFAM response regulator receiver	phoP	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1070056_1	349521.HCH_05222	2.85e-88	269.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,1RW3Z@1236|Gammaproteobacteria,1XI20@135619|Oceanospirillales	135619|Oceanospirillales	O	Pyruvate formate lyase-activating protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
k59_1306680_1	686340.Metal_0737	6.52e-93	285.0	COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,1RNCV@1236|Gammaproteobacteria,1XEDD@135618|Methylococcales	135618|Methylococcales	J	TIGRFAM MiaB-like tRNA modifying enzyme	-	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
k59_367285_1	1158762.KB898042_gene950	9.58e-57	193.0	COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,1RNUM@1236|Gammaproteobacteria,1WW3E@135613|Chromatiales	135613|Chromatiales	S	Deoxyribodipyrimidine photo-lyase-related protein	-	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP
k59_1419873_1	1123392.AQWL01000001_gene1443	9.73e-81	257.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2VHKJ@28216|Betaproteobacteria,1KSX1@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1770761_1	317025.Tcr_0122	2.29e-69	228.0	COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,1RS25@1236|Gammaproteobacteria,460MD@72273|Thiotrichales	72273|Thiotrichales	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,HDOD
k59_1594595_1	1410618.JNKI01000001_gene1369	2.89e-15	75.1	COG0325@1|root,COG0325@2|Bacteria,1TRDN@1239|Firmicutes,4H3EI@909932|Negativicutes	909932|Negativicutes	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	ylmE	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
k59_17518_1	1169154.KB897779_gene2854	1.95e-27	117.0	COG3225@1|root,COG3225@2|Bacteria,2GMTX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1834902_1	1137799.GZ78_24260	2.79e-98	306.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1XH8T@135619|Oceanospirillales	135619|Oceanospirillales	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_1480685_1	1219076.N646_2963	1.53e-89	268.0	arCOG03638@1|root,2Z7NN@2|Bacteria,1R3Y6@1224|Proteobacteria,1RTWY@1236|Gammaproteobacteria,1XU34@135623|Vibrionales	135623|Vibrionales	S	Protein of unknown function (DUF1538)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1538
k59_1536193_1	765912.Thimo_3321	1.32e-108	321.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,1WX9J@135613|Chromatiales	135613|Chromatiales	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_1536193_2	1451189.CFAL_06155	1.39e-05	49.3	COG1643@1|root,COG1643@2|Bacteria,2GIWX@201174|Actinobacteria,22M0Z@1653|Corynebacteriaceae	201174|Actinobacteria	L	ATP-dependent helicase	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_1006793_1	713586.KB900536_gene2586	1.19e-97	315.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales	135613|Chromatiales	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_954538_1	1035308.AQYY01000002_gene233	2.44e-78	251.0	COG1414@1|root,COG1414@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	3.6.4.12	ko:K03655,ko:K10439,ko:K11708	ko02010,ko02030,ko03440,map02010,map02030,map03440	M00212,M00319	-	-	ko00000,ko00001,ko00002,ko01000,ko02000,ko03400	3.A.1.15,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	AlbA_2,HATPase_c_4,HTH_IclR,IclR,Peripla_BP_4,VCBS
k59_715127_1	367299.JOEE01000003_gene2889	1.72e-111	333.0	COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria,4FEA3@85021|Intrasporangiaceae	201174|Actinobacteria	C	Malate dehydrogenase	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
k59_1070086_1	391615.ABSJ01000029_gene1940	1.93e-61	222.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1J4IV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_251201_1	338966.Ppro_2413	1.56e-06	52.8	COG2165@1|root,COG2165@2|Bacteria,1N1QJ@1224|Proteobacteria,42ZXF@68525|delta/epsilon subdivisions,2WV6V@28221|Deltaproteobacteria,43UYQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Pfam:N_methyl_2	oxpG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
k59_895572_1	1158756.AQXQ01000006_gene87	3.17e-48	170.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1WWI1@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_1419900_1	1163617.SCD_n01202	1.12e-64	216.0	COG0569@1|root,COG1226@1|root,COG0569@2|Bacteria,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,2VJ4Z@28216|Betaproteobacteria	28216|Betaproteobacteria	P	TrkA-N domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_N
k59_597119_1	207559.Dde_1859	1.81e-136	413.0	COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,42MDY@68525|delta/epsilon subdivisions,2WM0T@28221|Deltaproteobacteria,2MGC0@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Restriction endonuclease, type I, EcoRI, R subunit Type III	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HSDR_N,ResIII
k59_597119_2	1121456.ATVA01000013_gene998	1.66e-51	171.0	COG4804@1|root,COG4804@2|Bacteria,1NBWK@1224|Proteobacteria,42NXR@68525|delta/epsilon subdivisions,2WJ11@28221|Deltaproteobacteria,2MA73@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1016)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1016
k59_73813_1	1304883.KI912532_gene953	3.97e-118	361.0	COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,2VIV2@28216|Betaproteobacteria,2KVXE@206389|Rhodocyclales	206389|Rhodocyclales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1536208_1	1255043.TVNIR_3134	1.04e-24	96.3	COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,1SDIM@1236|Gammaproteobacteria,1WYSK@135613|Chromatiales	135613|Chromatiales	J	CRS1_YhbY	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
k59_1536208_2	396588.Tgr7_0980	1.15e-80	244.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,1WX98@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
k59_1536208_3	1268635.Loa_02735	3.65e-09	57.4	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1JCN3@118969|Legionellales	118969|Legionellales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1654703_2	382245.ASA_3761	1.59e-05	53.9	COG0583@1|root,COG0583@2|Bacteria,1MWUP@1224|Proteobacteria,1RNIC@1236|Gammaproteobacteria,1Y5G8@135624|Aeromonadales	135624|Aeromonadales	K	transcriptional regulator, ArgP	-	-	-	ko:K05596	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	HTH_1,LysR_substrate
k59_1654703_3	768671.ThimaDRAFT_4171	2.01e-87	274.0	29QS6@1|root,30BS1@2|Bacteria,1REGY@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_538743_1	1396418.BATQ01000118_gene4606	6.79e-07	55.8	COG0492@1|root,COG1053@1|root,COG4409@1|root,COG0492@2|Bacteria,COG1053@2|Bacteria,COG4409@2|Bacteria,46TCP@74201|Verrucomicrobia	74201|Verrucomicrobia	CEGO	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2,FAD_oxidored,SASA
k59_1846090_1	1121396.KB893012_gene4024	4.49e-169	485.0	COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42PH3@68525|delta/epsilon subdivisions,2WJZH@28221|Deltaproteobacteria,2MIN0@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
k59_1490965_1	553385.JEMF01000009_gene1898	5.92e-86	260.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,1XHWE@135619|Oceanospirillales	135619|Oceanospirillales	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
k59_840290_1	1128421.JAGA01000003_gene3247	3.39e-30	125.0	COG2304@1|root,COG2304@2|Bacteria,2NQHG@2323|unclassified Bacteria	2|Bacteria	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
k59_965673_1	66874.JOFS01000014_gene6084	3.07e-47	163.0	COG2141@1|root,COG2141@2|Bacteria,2GNQ3@201174|Actinobacteria	201174|Actinobacteria	C	PFAM luciferase-like	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1720333_1	400682.PAC_15710340	1.17e-44	157.0	COG0702@1|root,KOG2865@2759|Eukaryota,3A1E7@33154|Opisthokonta	33154|Opisthokonta	C	NAD(P)H-binding	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	3Beta_HSD,Epimerase,NAD_binding_10,RmlD_sub_bind
k59_1778917_1	398525.KB900701_gene5412	9.13e-12	65.1	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TRFY@28211|Alphaproteobacteria,3JU77@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_1778917_2	1211115.ALIQ01000204_gene4802	1.18e-40	136.0	COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2UBSZ@28211|Alphaproteobacteria,3NBF7@45404|Beijerinckiaceae	28211|Alphaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
k59_1720339_2	1274.HX89_09660	6.58e-29	105.0	COG1837@1|root,COG1837@2|Bacteria,2IQ4C@201174|Actinobacteria,1ZW6W@145357|Dermacoccaceae	201174|Actinobacteria	S	KH domain	-	GO:0008150,GO:0040007	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
k59_1720339_3	656024.FsymDg_3674	1.24e-05	46.2	COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,4ET25@85013|Frankiales	201174|Actinobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	GO:0008150,GO:0040007	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
k59_263161_1	1134474.O59_003560	0.000627	48.1	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1FGS4@10|Cellvibrio	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
k59_194866_1	313589.JNB_04735	8.86e-145	411.0	COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria,4FE8U@85021|Intrasporangiaceae	201174|Actinobacteria	E	ATP-binding protein	gluA	-	-	ko:K10008	ko02010,map02010	M00233	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.9	-	-	ABC_tran
k59_194866_2	367299.JOEE01000010_gene3375	2.95e-21	85.9	COG3450@1|root,COG3450@2|Bacteria,2IHPC@201174|Actinobacteria,4FJSH@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF861)	-	-	-	ko:K06995	-	-	-	-	ko00000	-	-	-	Cupin_3
k59_1193031_1	110319.CF8_4035	9.45e-08	52.8	COG0680@1|root,COG0680@2|Bacteria	2|Bacteria	C	spore germination	hybD	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
k59_1193031_2	1184609.KILIM_106_00010	1.17e-108	328.0	COG0374@1|root,COG0374@2|Bacteria,2GKQY@201174|Actinobacteria	201174|Actinobacteria	C	Large subunit	hybC	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_906784_2	246196.MSMEI_4033	2.01e-12	69.7	COG2801@1|root,COG2801@2|Bacteria,2GNRT@201174|Actinobacteria,234CZ@1762|Mycobacteriaceae	201174|Actinobacteria	L	PFAM Integrase, catalytic	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve
k59_1256333_1	452637.Oter_2206	3.33e-84	255.0	COG1136@1|root,COG1136@2|Bacteria,46SAX@74201|Verrucomicrobia	74201|Verrucomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_429118_1	1448389.BAVQ01000003_gene3526	3.2e-36	136.0	COG1732@1|root,COG1732@2|Bacteria,2GJWY@201174|Actinobacteria	201174|Actinobacteria	M	Glycine betaine	-	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
k59_1778919_1	1304865.JAGF01000001_gene364	3.23e-137	412.0	COG0488@1|root,COG0488@2|Bacteria,2GJ5M@201174|Actinobacteria,4F1TZ@85016|Cellulomonadaceae	201174|Actinobacteria	S	ATPases associated with a variety of cellular activities	yjjK	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_1602543_2	446471.Xcel_0291	3.4e-67	214.0	2DBXI@1|root,2ZBQ3@2|Bacteria,2GJN1@201174|Actinobacteria,4F3I2@85017|Promicromonosporaceae	201174|Actinobacteria	S	Peptidase M50B-like	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50B
k59_1846124_1	1121472.AQWN01000003_gene1539	2.24e-29	119.0	COG0006@1|root,COG0006@2|Bacteria,1TSXE@1239|Firmicutes,248AF@186801|Clostridia,2604W@186807|Peptococcaceae	186801|Clostridia	E	PFAM peptidase M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
k59_29304_2	585531.HMPREF0063_11416	4.05e-13	70.1	COG1694@1|root,COG3956@2|Bacteria,2GNKC@201174|Actinobacteria,4DV8P@85009|Propionibacteriales	201174|Actinobacteria	S	MazG nucleotide pyrophosphohydrolase domain	mazG	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0022607,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0035539,GO:0042454,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0047693,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
k59_1368473_1	765911.Thivi_0673	8.37e-26	111.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG2203@1|root,COG2984@1|root,COG3290@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2984@2|Bacteria,COG3290@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K10715,ko:K20974	ko02020,ko02024,ko02025,map02020,map02024,map02025	M00517,M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	CHASE,GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_1720355_1	748247.AZKH_1671	1.84e-75	238.0	COG0845@1|root,COG0845@2|Bacteria,1PJHF@1224|Proteobacteria,2VIRN@28216|Betaproteobacteria	28216|Betaproteobacteria	M	TIGRFAM efflux transporter, RND family, MFP subunit	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3
k59_429126_1	1496688.ER33_14805	6.39e-73	233.0	COG5361@1|root,COG5361@2|Bacteria,1G1YW@1117|Cyanobacteria,22TKK@167375|Cyanobium	1117|Cyanobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_84939_3	1123399.AQVE01000007_gene1069	4.15e-25	120.0	COG1028@1|root,COG1506@1|root,COG1028@2|Bacteria,COG1506@2|Bacteria,1MWC8@1224|Proteobacteria,1S1X8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	Belongs to the glycosyl hydrolase 8 (cellulase D) family	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_84939_4	378806.STAUR_2620	2.12e-29	115.0	28KN9@1|root,2ZA6H@2|Bacteria,1QWN9@1224|Proteobacteria,42P54@68525|delta/epsilon subdivisions,2WIJB@28221|Deltaproteobacteria,2YZV0@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_546476_1	1267005.KB911257_gene683	3.5e-70	237.0	COG0433@1|root,COG1484@1|root,COG0433@2|Bacteria,COG1484@2|Bacteria,1P0I3@1224|Proteobacteria,2U0J8@28211|Alphaproteobacteria,3N9D3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DUF853,DUF87
k59_1317991_1	367299.JOEE01000001_gene1465	8.08e-97	304.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4FEIA@85021|Intrasporangiaceae	201174|Actinobacteria	M	Penicillin-binding Protein	pbp5	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
k59_1428077_1	1095767.CAHD01000227_gene1032	1.64e-141	416.0	COG0606@1|root,COG0606@2|Bacteria,2GJIQ@201174|Actinobacteria,4F1UT@85016|Cellulomonadaceae	201174|Actinobacteria	O	PFAM magnesium chelatase ChlI subunit	comM	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_906813_1	631362.Thi970DRAFT_04077	1.13e-164	486.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales	135613|Chromatiales	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_1720364_2	1415779.JOMH01000001_gene2073	2.01e-46	168.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1X2ZN@135614|Xanthomonadales	135614|Xanthomonadales	S	Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
k59_136310_1	234267.Acid_2026	3.93e-38	139.0	COG1219@1|root,COG1219@2|Bacteria,3Y3MR@57723|Acidobacteria	57723|Acidobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_136310_2	694569.D7S_01879	1.02e-17	83.6	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1Y6WF@135625|Pasteurellales	135625|Pasteurellales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_263208_1	471852.Tcur_4221	1.14e-76	241.0	COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria,4EHYU@85012|Streptosporangiales	201174|Actinobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_263208_2	471856.Jden_0672	1.11e-17	80.9	COG0074@1|root,COG0074@2|Bacteria,2GK00@201174|Actinobacteria	201174|Actinobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_1544361_1	391615.ABSJ01000022_gene317	1.46e-42	152.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1J80F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0016020,GO:0022603,GO:0022604,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_1544361_2	395493.BegalDRAFT_0708	6.62e-40	149.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,45ZU0@72273|Thiotrichales	72273|Thiotrichales	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_1662982_2	335543.Sfum_0824	2.24e-21	93.6	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria,2MQTQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.17.1.10,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388,ko:K15022	ko00680,ko00720,ko01100,ko01120,ko01200,map00680,map00720,map01100,map01120,map01200	M00356,M00357,M00377,M00563,M00567	R00134,R04540,R11928,R11931,R11943,R11944	RC00011,RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_965734_1	1120963.KB894491_gene703	1.62e-74	235.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RM9E@1236|Gammaproteobacteria,2PZQS@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	P	ABC transporter	ycjV	-	-	ko:K10111,ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00204,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
k59_840337_1	572547.Amico_1843	1.33e-23	107.0	COG2206@1|root,COG2984@1|root,COG2206@2|Bacteria,COG2984@2|Bacteria,3TBWG@508458|Synergistetes	508458|Synergistetes	T	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HD,PAS_9
k59_136317_1	1380391.JIAS01000002_gene3143	9.98e-37	141.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2JQ2C@204441|Rhodospirillales	204441|Rhodospirillales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
k59_1082274_1	395494.Galf_1896	1.31e-30	114.0	COG0789@1|root,COG0789@2|Bacteria,1RGX6@1224|Proteobacteria,2VVBG@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K08365	-	-	-	-	ko00000,ko03000	-	-	-	MerR,MerR-DNA-bind,MerR_1
k59_907757_1	1265313.HRUBRA_01473	3.45e-24	102.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria,1J8WI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	AMP-binding enzyme	JD73_00810	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C_2,PP-binding
k59_1014095_3	225937.HP15_3210	2.12e-23	93.2	COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,1SCBI@1236|Gammaproteobacteria,468PG@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	zapA	GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000921,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032185,GO:0032505,GO:0032506,GO:0034622,GO:0042802,GO:0043093,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051301,GO:0061640,GO:0065003,GO:0070925,GO:0071840,GO:0090529,GO:1902410,GO:1903047	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
k59_605793_1	157783.LK03_20410	1.11e-26	106.0	COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,1S6Y7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	cytochrome b561	yodB	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
k59_1491827_1	880072.Desac_1172	2.26e-66	215.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,42S9I@68525|delta/epsilon subdivisions,2WNTW@28221|Deltaproteobacteria,2MQK3@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
k59_907764_1	680198.SCAB_9731	1.53e-11	68.9	COG1309@1|root,COG1309@2|Bacteria,2GJE0@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
k59_665242_1	224325.AF_1640	1.34e-37	134.0	COG1592@1|root,arCOG01097@2157|Archaea,2XXBF@28890|Euryarchaeota,246AT@183980|Archaeoglobi	183980|Archaeoglobi	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
k59_1083122_1	1249627.D779_0573	2.17e-94	288.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1WWPK@135613|Chromatiales	135613|Chromatiales	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_488615_1	322710.Avin_45260	5.26e-08	63.2	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	(Type IV) pilus	pilQ	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	-	ko:K02507,ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_1847118_1	1034345.CAEM01000023_gene874	5.92e-19	93.6	COG0367@1|root,COG0367@2|Bacteria,2GJIM@201174|Actinobacteria,4CUI5@84998|Coriobacteriia	84998|Coriobacteriia	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_1257208_1	1198232.CYCME_2014	4.13e-66	209.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria,4605T@72273|Thiotrichales	72273|Thiotrichales	O	molecular chaperone	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
k59_779215_1	1192034.CAP_4625	6.77e-22	95.9	COG0366@1|root,COG0366@2|Bacteria,1PDXT@1224|Proteobacteria,42YHJ@68525|delta/epsilon subdivisions,2WUMP@28221|Deltaproteobacteria,2Z2KW@29|Myxococcales	28221|Deltaproteobacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
k59_547153_2	1097668.BYI23_C006160	3.57e-09	61.2	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VK0G@28216|Betaproteobacteria,1K40E@119060|Burkholderiaceae	28216|Betaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_312665_1	1095769.CAHF01000017_gene24	1.57e-55	185.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VHPJ@28216|Betaproteobacteria,474R8@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	periplasmic	dctP	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
k59_379507_1	880072.Desac_2806	1.14e-77	250.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,42MYF@68525|delta/epsilon subdivisions,2WJE3@28221|Deltaproteobacteria,2MQEN@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DHH family	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_30444_1	1095767.CAHD01000213_gene638	1.68e-114	335.0	COG0682@1|root,COG0682@2|Bacteria,2GKSS@201174|Actinobacteria,4F25U@85016|Cellulomonadaceae	201174|Actinobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	LGT
k59_841026_1	1304878.AUGD01000027_gene1084	5.04e-52	174.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2U1EJ@28211|Alphaproteobacteria,3JX7M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	U	AAA domain	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22
k59_1369190_1	398767.Glov_2105	3.74e-08	55.1	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,42TVX@68525|delta/epsilon subdivisions,2WP4F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Lytic transglycosylase catalytic	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	DUF4124,SLT
k59_1369190_2	589865.DaAHT2_2221	7.56e-20	85.1	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,42M39@68525|delta/epsilon subdivisions,2WJEZ@28221|Deltaproteobacteria,2MI50@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
k59_379511_1	886379.AEWI01000091_gene1610	3.7e-33	127.0	COG5659@1|root,COG5659@2|Bacteria,4NQCF@976|Bacteroidetes,2FXFH@200643|Bacteroidia	976|Bacteroidetes	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_1257224_1	216594.MMAR_1197	1.07e-14	75.9	COG2128@1|root,COG2128@2|Bacteria,2I829@201174|Actinobacteria,23511@1762|Mycobacteriaceae	201174|Actinobacteria	L	carboxymuconolactone decarboxylase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	CMD
k59_488641_2	1249627.D779_2947	2.38e-29	117.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria,1WWCP@135613|Chromatiales	135613|Chromatiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_966734_1	1304865.JAGF01000001_gene3845	8.04e-185	522.0	COG0004@1|root,COG0004@2|Bacteria,2GIZK@201174|Actinobacteria,4F1S2@85016|Cellulomonadaceae	201174|Actinobacteria	P	Ammonium Transporter Family	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_379515_1	671143.DAMO_3069	5.69e-110	329.0	COG0156@1|root,COG0156@2|Bacteria,2NNMX@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.29,2.3.1.47,2.3.1.50	ko:K00639,ko:K00652,ko:K00654	ko00260,ko00600,ko00780,ko01100,ko04071,ko04138,map00260,map00600,map00780,map01100,map04071,map04138	M00094,M00099,M00123,M00573,M00577	R00371,R01281,R03210,R10124	RC00004,RC00039,RC00394,RC02725,RC02849	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_379515_2	1033802.SSPSH_000296	1.11e-13	68.2	COG0236@1|root,COG0236@2|Bacteria,1NHQD@1224|Proteobacteria,1SA25@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	acyl carrier protein	AKN40_0794	-	-	-	-	-	-	-	-	-	-	-	PP-binding
k59_195623_1	471853.Bcav_3485	3.25e-141	419.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the DEAD box helicase family	rhlE1	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
k59_1132250_1	765911.Thivi_3897	1.25e-95	308.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,1WW9S@135613|Chromatiales	135613|Chromatiales	E	Bacterial transglutaminase-like N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
k59_1428815_1	765912.Thimo_2750	1.39e-85	265.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1WXB6@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_841040_1	1049564.TevJSym_bp00150	1.67e-144	415.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1J4QF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.6,2.1.3.9	ko:K00611,ko:K09065,ko:K13252	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_605843_1	479431.Namu_1896	2.62e-49	165.0	COG2885@1|root,COG2885@2|Bacteria,2I4PT@201174|Actinobacteria	201174|Actinobacteria	M	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157
k59_1083179_1	335543.Sfum_1905	1.4e-73	232.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,42NBV@68525|delta/epsilon subdivisions,2WK0F@28221|Deltaproteobacteria,2MQTX@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
k59_605848_1	358220.C380_21160	1.34e-36	133.0	COG1877@1|root,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,2VRQ8@28216|Betaproteobacteria,4ADUM@80864|Comamonadaceae	28216|Betaproteobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
k59_1721161_1	446462.Amir_6895	6.88e-11	62.8	COG1011@1|root,COG1011@2|Bacteria,2IHVB@201174|Actinobacteria,4E415@85010|Pseudonocardiales	201174|Actinobacteria	S	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
k59_1721161_2	1236542.BALM01000027_gene487	5.64e-12	65.1	COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,1RRDQ@1236|Gammaproteobacteria,2QAI7@267890|Shewanellaceae	1236|Gammaproteobacteria	V	PFAM multi antimicrobial extrusion protein MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
k59_1847204_1	525146.Ddes_2231	8.65e-79	256.0	COG3972@1|root,COG3972@2|Bacteria,1R42E@1224|Proteobacteria,42VFZ@68525|delta/epsilon subdivisions,2WU2H@28221|Deltaproteobacteria,2MB05@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	UvrD-like helicase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	UvrD_C_2
k59_1491902_1	1033802.SSPSH_003627	1.11e-67	218.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,1RYM6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_673244_1	1713.JOFV01000005_gene2130	1.84e-76	240.0	COG0715@1|root,COG0715@2|Bacteria,2GK7X@201174|Actinobacteria,4F1KR@85016|Cellulomonadaceae	201174|Actinobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
k59_1376845_1	765913.ThidrDRAFT_1634	1.08e-108	322.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1WW8T@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
k59_1861318_1	396588.Tgr7_2406	4.17e-74	243.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1WX4H@135613|Chromatiales	135613|Chromatiales	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	OapA,Peptidase_M23
k59_731810_2	237368.SCABRO_01410	5.41e-11	61.2	COG0778@1|root,COG0778@2|Bacteria,2J2XW@203682|Planctomycetes	203682|Planctomycetes	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
k59_849096_1	886293.Sinac_1231	1.27e-09	63.9	COG3464@1|root,COG3464@2|Bacteria,2J4EX@203682|Planctomycetes	203682|Planctomycetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1610959_2	1415778.JQMM01000001_gene2175	3.32e-204	575.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1J56Y@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	-	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_980836_1	1137268.AZXF01000013_gene1629	1.37e-34	133.0	COG0340@1|root,COG0340@2|Bacteria,2GN8Q@201174|Actinobacteria,4EHVP@85012|Streptosporangiales	201174|Actinobacteria	H	Biotin protein ligase C terminal domain	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
k59_1333032_1	471853.Bcav_3478	3.19e-71	225.0	COG5006@1|root,COG5006@2|Bacteria,2GJKB@201174|Actinobacteria	201174|Actinobacteria	K	permease, DMT superfamily	-	-	-	ko:K11939	-	-	-	-	ko00000,ko02000	2.A.7.3.6	-	-	EamA
k59_1333033_1	889378.Spiaf_2411	5.28e-82	252.0	COG0667@1|root,COG0667@2|Bacteria,2JBDE@203691|Spirochaetes	203691|Spirochaetes	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1610963_1	314345.SPV1_07004	3.11e-59	206.0	COG0574@1|root,COG0574@2|Bacteria,1P35R@1224|Proteobacteria	1224|Proteobacteria	G	Pyruvate phosphate dikinase	-	-	-	-	-	-	-	-	-	-	-	-	LTD,PPDK_N
k59_980838_1	2340.JV46_06530	5.8e-99	293.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria,1J4T6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	riboflavin synthase, alpha	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
k59_42844_1	1173027.Mic7113_0504	5.88e-51	167.0	COG1515@1|root,COG1515@2|Bacteria,1G2HF@1117|Cyanobacteria,1H8TY@1150|Oscillatoriales	1117|Cyanobacteria	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
k59_144970_1	1120950.KB892793_gene2370	1.97e-33	130.0	COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria,4DN4X@85009|Propionibacteriales	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0040007,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_144970_2	446466.Cfla_1946	1.61e-10	62.0	COG1660@1|root,COG1660@2|Bacteria,2GMWB@201174|Actinobacteria,4F0Z5@85016|Cellulomonadaceae	201174|Actinobacteria	S	Displays ATPase and GTPase activities	yvcJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
k59_437960_1	765910.MARPU_03930	2.35e-93	292.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales	135613|Chromatiales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_393347_1	1121948.AUAC01000006_gene518	3.53e-17	87.8	COG1361@1|root,COG2885@1|root,COG1361@2|Bacteria,COG2885@2|Bacteria,1R5G4@1224|Proteobacteria,2UC86@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	TIGRFAM conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
k59_1376859_1	864069.MicloDRAFT_00028230	8.25e-32	124.0	COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria,2TRKA@28211|Alphaproteobacteria,1JWYG@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_496695_1	870187.Thini_1163	3.46e-76	241.0	2CB8R@1|root,2Z90U@2|Bacteria,1R4DV@1224|Proteobacteria,1RPSZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1861336_1	880072.Desac_0096	4.72e-17	88.6	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_8,PAS_9,Response_reg,SBP_bac_3
k59_980851_2	1320556.AVBP01000012_gene3572	1.34e-22	97.8	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Zn-dependent dipeptidase, microsomal dipeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M19
k59_1376866_1	526225.Gobs_2302	4.82e-14	76.6	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4ERW2@85013|Frankiales	201174|Actinobacteria	G	SMART alpha amylase, catalytic sub domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_1020906_1	1268237.G114_08175	1.48e-90	279.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria,1Y3X9@135624|Aeromonadales	135624|Aeromonadales	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_1201921_2	1033730.CAHG01000003_gene133	5.89e-10	62.4	COG0787@1|root,COG0787@2|Bacteria,2GM2Y@201174|Actinobacteria,4DNHM@85009|Propionibacteriales	201174|Actinobacteria	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_1092576_1	1133850.SHJG_8808	2.58e-61	195.0	COG3212@1|root,COG3212@2|Bacteria,2IF4I@201174|Actinobacteria	201174|Actinobacteria	S	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_980862_1	590998.Celf_2130	4.61e-76	235.0	COG1180@1|root,COG1180@2|Bacteria,2GN2B@201174|Actinobacteria,4F0HU@85016|Cellulomonadaceae	201174|Actinobacteria	C	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_980862_2	1121019.AUMN01000002_gene423	1.95e-07	53.5	COG0349@1|root,COG0349@2|Bacteria,2GKNM@201174|Actinobacteria,1W8GE@1268|Micrococcaceae	201174|Actinobacteria	J	3'-5' exonuclease	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
k59_1139491_2	1159870.KB907784_gene3499	1.03e-19	84.7	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2VSCK@28216|Betaproteobacteria,3T4GB@506|Alcaligenaceae	28216|Betaproteobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
k59_320901_1	484019.THA_196	1.94e-08	57.4	COG0205@1|root,COG0205@2|Bacteria,2GBXZ@200918|Thermotogae	200918|Thermotogae	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_320901_2	1041138.KB890221_gene1460	2.9e-07	54.7	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2TUND@28211|Alphaproteobacteria,4B8V6@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	response regulator	fixJ	-	-	ko:K14987	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_276040_1	1242864.D187_002120	2.18e-31	125.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_276040_2	1267535.KB906767_gene3655	5.58e-32	120.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria,2JJS7@204432|Acidobacteriia	204432|Acidobacteriia	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
k59_673291_1	1322246.BN4_10071	7.53e-69	223.0	COG0069@1|root,COG1145@1|root,COG0069@2|Bacteria,COG1145@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2WJ17@28221|Deltaproteobacteria,2M82G@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the glutamate synthase family	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_16,Glu_synthase
k59_1610993_1	1713.JOFV01000003_gene1452	5.16e-35	129.0	COG4330@1|root,COG4330@2|Bacteria,2IBF3@201174|Actinobacteria,4F2K6@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1361)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1361
k59_1610993_2	469383.Cwoe_1974	9.26e-40	136.0	COG1695@1|root,COG1695@2|Bacteria,2GRHC@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
k59_1139503_1	1049564.TevJSym_bq00030	3.19e-18	86.3	COG1385@1|root,COG4660@1|root,COG1385@2|Bacteria,COG4660@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,1J5UQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
k59_1610994_1	1121920.AUAU01000009_gene1850	5e-34	130.0	COG0436@1|root,COG0436@2|Bacteria,3Y2VQ@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_1333099_1	321955.AAGP01000043_gene2597	2.4e-16	80.9	COG3335@1|root,COG3335@2|Bacteria,2GJQI@201174|Actinobacteria,4FAES@85019|Brevibacteriaceae	201174|Actinobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_32
k59_1333099_2	1048339.KB913029_gene156	4.26e-09	57.4	COG3335@1|root,COG3335@2|Bacteria,2GJQI@201174|Actinobacteria,4ERUS@85013|Frankiales	201174|Actinobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_32
k59_849139_1	314278.NB231_08132	1.31e-111	355.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_496735_1	55207.KP22_04315	2.58e-48	175.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1MQ4M@122277|Pectobacterium	1236|Gammaproteobacteria	J	Phenylalanyl-tRNA synthetase beta	pheT	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_2160,iPC815.YPO2428	B3_4,B5,FDX-ACB,tRNA_bind
k59_276065_2	479434.Sthe_0609	5.79e-24	99.0	COG1595@1|root,COG1595@2|Bacteria,2G6MG@200795|Chloroflexi,27YI4@189775|Thermomicrobia	189775|Thermomicrobia	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_786094_1	1283287.KB822579_gene2064	1.8e-139	421.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4DN4J@85009|Propionibacteriales	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_849144_1	1184607.AUCHE_05_03610	4.63e-63	206.0	COG3804@1|root,COG3804@2|Bacteria,2GKE3@201174|Actinobacteria,4F7CW@85018|Dermatophilaceae	201174|Actinobacteria	S	Dihydrodipicolinate reductase, N-terminus	-	-	1.4.1.12,1.4.1.26	ko:K21672	ko00310,ko00330,ko00472,map00310,map00330,map00472	-	R02825,R04200,R04201,R04687,R04688	RC00249,RC00790	ko00000,ko00001,ko01000	-	-	-	DapB_N
k59_849144_2	1123392.AQWL01000003_gene237	1.45e-20	92.0	29MQ2@1|root,308MT@2|Bacteria,1REUR@1224|Proteobacteria,2VXQA@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_921839_1	1192034.CAP_8428	2.18e-42	155.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WKYA@28221|Deltaproteobacteria,2YU1C@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefB	-	-	ko:K03455,ko:K11745,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.1,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
k59_496744_1	1134912.AJTV01000013_gene609	2.38e-88	278.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1437040_1	1177154.Y5S_02125	1.27e-65	215.0	COG0069@1|root,COG2146@1|root,COG0069@2|Bacteria,COG2146@2|Bacteria,1MU7B@1224|Proteobacteria,1RP1C@1236|Gammaproteobacteria,1XIUD@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the glutamate synthase family	-	-	2.1.1.21	ko:K22083	ko00680,ko01120,map00680,map01120	-	R01586	RC00554	ko00000,ko00001,ko01000	-	-	-	Glu_synthase,zf-CDGSH
k59_1266843_1	644968.DFW101_3318	3.19e-42	154.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42MBP@68525|delta/epsilon subdivisions,2WJAJ@28221|Deltaproteobacteria,2M9MS@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1333137_1	590998.Celf_1082	9.02e-127	380.0	COG1080@1|root,COG1080@2|Bacteria,2GIZZ@201174|Actinobacteria	201174|Actinobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_438020_1	1220535.IMCC14465_07110	7.5e-101	309.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2TR3H@28211|Alphaproteobacteria,4BPPI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_42948_1	1121405.dsmv_0691	2.39e-98	302.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales	68525|delta/epsilon subdivisions	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1376917_1	177437.HRM2_40360	1.98e-115	353.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,43AD6@68525|delta/epsilon subdivisions,2WJCC@28221|Deltaproteobacteria,2MJ5W@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM sulfate transporter	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_921863_1	335543.Sfum_0605	4.07e-65	216.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,2MR7G@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1092640_1	1458357.BG58_37890	4.83e-15	74.3	COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2VJF4@28216|Betaproteobacteria,1K3VW@119060|Burkholderiaceae	28216|Betaproteobacteria	H	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site	cbbL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
k59_982287_1	439235.Dalk_2655	3.13e-91	278.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42QAU@68525|delta/epsilon subdivisions,2WMD2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	ko:K11731	ko00281,map00281	-	R08089	RC01893	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_556200_1	1380354.JIAN01000008_gene3461	4.08e-204	583.0	COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria,4F1P0@85016|Cellulomonadaceae	201174|Actinobacteria	P	Oligopeptide dipeptide ABC transporter domain protein	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_786800_2	754252.PFREUD_10190	8.93e-07	50.8	COG2135@1|root,COG2135@2|Bacteria,2GKY8@201174|Actinobacteria,4DPFJ@85009|Propionibacteriales	201174|Actinobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
k59_982301_1	446469.Sked_32250	1.45e-101	322.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2GKI9@201174|Actinobacteria	201174|Actinobacteria	C	FAD linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8
k59_145921_1	1247963.JPHU01000002_gene2733	3.22e-62	213.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2TRKK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	mechanosensitive ion channel	kefA	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	DUF3772,MS_channel
k59_1787492_1	555079.Toce_0698	5.55e-70	226.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,42FFC@68295|Thermoanaerobacterales	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,RnfC_N,SLBB
k59_556210_1	935863.AWZR01000005_gene2470	3.59e-11	64.3	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1X36A@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_556210_2	999141.GME_17697	9.19e-40	155.0	COG0128@1|root,COG0287@1|root,COG0128@2|Bacteria,COG0287@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1XIJ8@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	1.3.1.12,2.5.1.19	ko:K00210,ko:K00800	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00022,M00025	R01728,R03460	RC00125,RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase,PDH
k59_982309_1	666685.R2APBS1_0129	3.05e-65	206.0	COG0800@1|root,COG0800@2|Bacteria,1MUVJ@1224|Proteobacteria,1RPDF@1236|Gammaproteobacteria,1X4EU@135614|Xanthomonadales	135614|Xanthomonadales	G	Aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
k59_1862811_3	1042876.PPS_3732	1.81e-10	58.2	COG2257@1|root,COG2257@2|Bacteria,1N7F1@1224|Proteobacteria,1SCWV@1236|Gammaproteobacteria,1YVJX@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	FlhB HrpN YscU SpaS Family	flhB2	-	-	ko:K04061	-	-	-	-	ko00000,ko02044	-	-	-	Bac_export_2
k59_1437884_1	1187851.A33M_4207	3.88e-120	350.0	COG0543@1|root,COG0543@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	gltA	-	1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14	ko:K00266,ko:K00528,ko:K02823	ko00240,ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248,R10159	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,Fer4_20,NAD_binding_1,Pyr_redox_2
k59_1334528_1	1101195.Meth11DRAFT_0229	4.44e-06	50.4	COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,2VPN6@28216|Betaproteobacteria,2KMSU@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Protein of unknown function, DUF484	-	-	-	ko:K09921	-	-	-	-	ko00000	-	-	-	DUF484
k59_1502331_1	357808.RoseRS_0010	5.68e-38	149.0	COG0823@1|root,COG0823@2|Bacteria,2G8T5@200795|Chloroflexi,376FH@32061|Chloroflexia	32061|Chloroflexia	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
k59_923279_1	710696.Intca_2462	1.26e-58	199.0	COG1070@1|root,COG1070@2|Bacteria,2GNCR@201174|Actinobacteria,4FJVY@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the FGGY kinase family	-	-	2.7.1.12	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	-	R01737	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
k59_1267911_1	390989.JOEG01000001_gene4827	2.07e-19	92.8	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GMN4@201174|Actinobacteria,4DECF@85008|Micromonosporales	201174|Actinobacteria	GT	PEP-utilising enzyme, mobile domain	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_849981_1	1168034.FH5T_06970	3.54e-93	286.0	COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,4NEZC@976|Bacteroidetes,2FSM8@200643|Bacteroidia	976|Bacteroidetes	G	Glucose / Sorbosone dehydrogenase	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,GSDH
k59_321825_1	1192034.CAP_6980	7.83e-10	61.6	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,42N2B@68525|delta/epsilon subdivisions,2WJS9@28221|Deltaproteobacteria,2YVFZ@29|Myxococcales	28221|Deltaproteobacteria	S	Major facilitator	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_394834_1	2754.EH55_05180	6.12e-20	95.5	COG4585@1|root,COG4585@2|Bacteria,3TAQ1@508458|Synergistetes	508458|Synergistetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_101377_1	765913.ThidrDRAFT_1101	3.21e-72	239.0	COG3598@1|root,COG3598@2|Bacteria,1PWN4@1224|Proteobacteria,1T47X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_25
k59_982358_1	452637.Oter_4342	3.93e-76	238.0	COG1312@1|root,COG1312@2|Bacteria,46UDP@74201|Verrucomicrobia,3K8B6@414999|Opitutae	414999|Opitutae	G	Catalyzes the dehydration of D-mannonate	-	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	UxuA
k59_674220_1	525897.Dbac_2072	2.81e-21	89.0	2DC7W@1|root,2ZD7C@2|Bacteria,1QU8S@1224|Proteobacteria,42TNH@68525|delta/epsilon subdivisions,2WQ32@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Chalcone isomerase-like	-	-	-	-	-	-	-	-	-	-	-	-	Chalcone_3
k59_211468_1	439375.Oant_2962	3.28e-78	251.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,1J3V1@118882|Brucellaceae	28211|Alphaproteobacteria	E	Glutamine amidotransferase domain	asnO	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_286722_1	697282.Mettu_1512	3.4e-59	187.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,1RW0G@1236|Gammaproteobacteria,1XDM0@135618|Methylococcales	135618|Methylococcales	C	PFAM NADH ubiquinone	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
k59_286722_2	159087.Daro_0982	6.69e-58	192.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,2VJT0@28216|Betaproteobacteria,2KVAX@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hoxH	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
k59_621647_1	911045.PSE_0276	4.07e-86	272.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_681363_1	1123073.KB899242_gene1461	5.15e-95	295.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1XA61@135614|Xanthomonadales	135614|Xanthomonadales	CE	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,Pyr_redox_2
k59_211482_1	1163409.UUA_16183	2.83e-10	60.1	COG3137@1|root,COG3137@2|Bacteria,1MWI4@1224|Proteobacteria,1RN4J@1236|Gammaproteobacteria,1X57Z@135614|Xanthomonadales	135614|Xanthomonadales	M	salt-induced outer membrane protein	-	-	-	ko:K07283	-	-	-	-	ko00000	-	-	-	DUF481
k59_211482_2	1255043.TVNIR_2817	1.97e-39	135.0	COG1051@1|root,COG1051@2|Bacteria,1QUM0@1224|Proteobacteria,1SYT8@1236|Gammaproteobacteria,1X2J5@135613|Chromatiales	135613|Chromatiales	F	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
k59_993289_1	313612.L8106_28706	1.01e-23	102.0	COG5361@1|root,COG5361@2|Bacteria,1GQXQ@1117|Cyanobacteria,1HI4I@1150|Oscillatoriales	1117|Cyanobacteria	S	Neurotransmitter-gated ion-channel ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Neur_chan_LBD,Neur_chan_memb
k59_1209491_1	1121440.AUMA01000003_gene2932	3.96e-21	96.3	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,43D10@68525|delta/epsilon subdivisions,2X88V@28221|Deltaproteobacteria,2M8V3@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
k59_1209491_2	742738.HMPREF9460_00299	4.51e-07	52.0	COG0427@1|root,COG0427@2|Bacteria,1TPHC@1239|Firmicutes,247V0@186801|Clostridia,267QN@186813|unclassified Clostridiales	186801|Clostridia	C	Acetyl-CoA hydrolase/transferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
k59_504485_2	522306.CAP2UW1_3650	2.99e-52	179.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2VPV5@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_153111_1	1034943.BN1094_00184	1.75e-109	341.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1JC56@118969|Legionellales	118969|Legionellales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N,IF2_assoc
k59_1029023_1	1121920.AUAU01000012_gene2702	2.46e-29	120.0	COG0702@1|root,COG0702@2|Bacteria,3Y666@57723|Acidobacteria	57723|Acidobacteria	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
k59_1510867_1	754477.Q7C_859	3.57e-85	276.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,45ZWT@72273|Thiotrichales	72273|Thiotrichales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_153910_1	411684.HPDFL43_08967	2.97e-18	83.6	COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,2TUX0@28211|Alphaproteobacteria,43IWC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1365)	-	-	-	ko:K09701	-	-	-	-	ko00000	-	-	-	DUF1365
k59_1445462_1	1276920.ADIAG_00434	5.06e-36	134.0	COG1073@1|root,COG1073@2|Bacteria,2IHUE@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_5
k59_446654_1	1120945.ATUW01000011_gene1267	1.64e-32	124.0	COG0189@1|root,COG0189@2|Bacteria,2HI2Z@201174|Actinobacteria,4D3C4@85005|Actinomycetales	201174|Actinobacteria	HJ	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	GSH-S_ATP
k59_1346772_1	713586.KB900536_gene2586	9.71e-133	413.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales	135613|Chromatiales	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_1276668_1	1163408.UU9_15532	1.28e-51	182.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1X486@135614|Xanthomonadales	135614|Xanthomonadales	I	3-hydroxyacyl-coa dehydrogenase	fadJ	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_1385747_1	742823.HMPREF9465_00390	1.76e-73	237.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,2VH1A@28216|Betaproteobacteria,4PQDX@995019|Sutterellaceae	28216|Betaproteobacteria	J	tRNA synthetases class II (D, K and N)	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_1346778_1	316273.XCV0830	1.5e-17	82.4	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1X3JZ@135614|Xanthomonadales	135614|Xanthomonadales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_1346778_2	396588.Tgr7_0768	4.26e-147	429.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,1WWCK@135613|Chromatiales	135613|Chromatiales	M	Peptidoglycan polymerase that is essential for cell division	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_1619718_1	1123401.JHYQ01000017_gene2509	2.04e-42	148.0	292F7@1|root,2ZPZF@2|Bacteria,1RGFI@1224|Proteobacteria,1S48P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1875014_1	1283300.ATXB01000001_gene2079	1.08e-61	202.0	COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	succinylglutamate desuccinylase aspartoacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
k59_329673_1	394.NGR_c35870	7.57e-175	504.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2U0ZH@28211|Alphaproteobacteria,4BJ1H@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_857499_1	933262.AXAM01000050_gene3481	9.23e-72	236.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42N2U@68525|delta/epsilon subdivisions,2WJRR@28221|Deltaproteobacteria,2MI9B@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1680456_1	105559.Nwat_0593	4.27e-133	391.0	COG0438@1|root,COG0438@2|Bacteria,1MUTA@1224|Proteobacteria,1RS31@1236|Gammaproteobacteria,1WXR2@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_563868_1	247634.GPB2148_2683	1.44e-72	233.0	COG2911@1|root,COG2911@2|Bacteria,1NHQB@1224|Proteobacteria,1SVEG@1236|Gammaproteobacteria,1JC1B@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Porin_2
k59_622474_2	497964.CfE428DRAFT_0827	3.73e-42	154.0	COG2223@1|root,COG2223@2|Bacteria,46UH2@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_406977_1	479435.Kfla_3720	1.1e-12	66.2	COG1028@1|root,COG1028@2|Bacteria,2GMEH@201174|Actinobacteria,4DNZG@85009|Propionibacteriales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1210250_1	1396141.BATP01000057_gene3037	1.18e-114	348.0	COG0449@1|root,COG0449@2|Bacteria,46S94@74201|Verrucomicrobia,2ITND@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Glutamine amidotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	GATase_6,SIS
k59_288094_1	102232.GLO73106DRAFT_00008120	3.14e-63	205.0	COG0463@1|root,COG0463@2|Bacteria,1G153@1117|Cyanobacteria	1117|Cyanobacteria	M	Glycosyl transferase, family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
k59_682195_1	1149133.ppKF707_0810	6.48e-61	211.0	COG2010@1|root,COG2010@2|Bacteria,1MVYK@1224|Proteobacteria,1RQH2@1236|Gammaproteobacteria,1YEVD@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1445489_1	1304865.JAGF01000001_gene1829	3.47e-31	117.0	COG0785@1|root,COG0785@2|Bacteria,2GJW3@201174|Actinobacteria,4F1PM@85016|Cellulomonadaceae	201174|Actinobacteria	O	PFAM cytochrome c biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
k59_1445489_2	590998.Celf_0915	1.7e-12	68.6	COG1333@1|root,COG1333@2|Bacteria,2GMGH@201174|Actinobacteria,4F0PR@85016|Cellulomonadaceae	201174|Actinobacteria	O	ResB-like family	-	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
k59_446682_1	1227349.C170_03013	1.85e-09	64.3	COG3547@1|root,COG3547@2|Bacteria,1V427@1239|Firmicutes,4HGY6@91061|Bacilli,26TGK@186822|Paenibacillaceae	91061|Bacilli	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_212319_1	497321.C664_06683	6.36e-27	113.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VI20@28216|Betaproteobacteria,2KVS9@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC-type Fe3 transport system, permease component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_1619741_1	56780.SYN_02371	5.15e-75	238.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,2MQ94@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_1510923_1	388399.SSE37_21945	1.87e-63	203.0	COG0834@1|root,COG0834@2|Bacteria,1R5B4@1224|Proteobacteria,2U2WD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	ET	COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_622495_1	1328313.DS2_07843	1.04e-58	204.0	COG3408@1|root,COG3408@2|Bacteria,1NJCP@1224|Proteobacteria,1RXM5@1236|Gammaproteobacteria,469MS@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Bacterial alpha-L-rhamnosidase C-terminal domain	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
k59_1510927_1	376733.IT41_10120	3.66e-96	293.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2TRET@28211|Alphaproteobacteria,2PUH8@265|Paracoccus	28211|Alphaproteobacteria	C	Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate	gltP	-	-	ko:K11103	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.23.1.3,2.A.23.1.6,2.A.23.1.7	-	-	SDF
k59_1210267_1	1121403.AUCV01000012_gene4103	3.84e-52	182.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria,2MHQD@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthetase large chain oligomerisation	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_1210267_2	671143.DAMO_2140	1.88e-23	97.8	COG0505@1|root,COG0505@2|Bacteria,2NNMS@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the CarA family	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1383	CPSase_sm_chain,GATase
k59_622499_1	670307.HYPDE_23828	8.83e-83	268.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria,3N6JN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	UvrD-like helicase C-terminal domain	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_935135_1	247490.KSU1_C1634	1.17e-166	485.0	COG0021@1|root,COG0021@2|Bacteria,2IXIA@203682|Planctomycetes	203682|Planctomycetes	G	Belongs to the transketolase family	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_1510935_1	391615.ABSJ01000005_gene602	4.14e-166	480.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1J51V@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	iECABU_c1320.ECABU_c45100	ThiC-associated,ThiC_Rad_SAM
k59_994390_1	710687.KI912270_gene5023	5.08e-82	258.0	COG3864@1|root,COG3864@2|Bacteria,2GWVA@201174|Actinobacteria,2373E@1762|Mycobacteriaceae	201174|Actinobacteria	S	VWA-like domain (DUF2201)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2201,DUF2201_N
k59_1445513_1	1283283.ATXA01000037_gene2302	9.31e-137	395.0	COG1260@1|root,COG1260@2|Bacteria,2GKHB@201174|Actinobacteria,4ERYP@85013|Frankiales	201174|Actinobacteria	I	PFAM Myo-inositol-1-phosphate synthase	ino1	GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
k59_329726_1	1151061.CAJY01000015_gene588	6.07e-17	85.5	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,2GM5R@201174|Actinobacteria	201174|Actinobacteria	CE	Belongs to the aldehyde dehydrogenase family	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh
k59_857547_1	590998.Celf_3742	3.92e-90	275.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4F0IR@85016|Cellulomonadaceae	201174|Actinobacteria	E	PFAM aminotransferase class I and II	aspB	-	2.6.1.1,2.6.1.17,2.6.1.2,2.6.1.66	ko:K00812,ko:K14260,ko:K14267	ko00220,ko00250,ko00270,ko00290,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01130,map01210,map01230	M00016	R00258,R00355,R00694,R00734,R00896,R01215,R02433,R02619,R04475,R05052	RC00006,RC00008,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_622526_1	1121405.dsmv_2282	1.11e-64	211.0	COG3673@1|root,COG3673@2|Bacteria,1NFRW@1224|Proteobacteria,42TBM@68525|delta/epsilon subdivisions,2WP92@28221|Deltaproteobacteria,2MPCA@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Uncharacterized alpha/beta hydrolase domain (DUF2235)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2235
k59_1619774_1	933262.AXAM01000059_gene2916	2.32e-73	245.0	COG0642@1|root,COG3221@1|root,COG4251@1|root,COG0642@2|Bacteria,COG3221@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,43CDW@68525|delta/epsilon subdivisions,2X8IN@28221|Deltaproteobacteria,2MPP7@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,HAMP,HATPase_c,HisKA,Hpt,PAS_9,Response_reg
k59_1029137_1	768671.ThimaDRAFT_0873	4.2e-182	520.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGB@1236|Gammaproteobacteria,1X1MI@135613|Chromatiales	135613|Chromatiales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_793083_1	28042.GU90_18335	7.25e-24	100.0	COG1925@1|root,COG3412@1|root,COG1925@2|Bacteria,COG3412@2|Bacteria,2IHRN@201174|Actinobacteria,4E2JW@85010|Pseudonocardiales	201174|Actinobacteria	G	PTS system fructose IIA component	dhaM	-	2.7.1.121	ko:K05881	ko00561,map00561	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000,ko02000	-	-	-	EIIA-man,PTS-HPr
k59_793083_2	446466.Cfla_1458	4.54e-62	199.0	COG1461@1|root,COG1461@2|Bacteria,2HEQ9@201174|Actinobacteria,4F153@85016|Cellulomonadaceae	201174|Actinobacteria	S	TIGRFAM dihydroxyacetone kinase, L subunit	dhaL	-	2.7.1.121	ko:K05879	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak2
k59_154002_1	56780.SYN_02036	1.88e-68	230.0	COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,42NNC@68525|delta/epsilon subdivisions,2WKQW@28221|Deltaproteobacteria,2MQ7A@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
k59_1147111_1	1123487.KB892865_gene1394	2.55e-23	103.0	COG0749@1|root,COG0749@2|Bacteria,1MWX7@1224|Proteobacteria,2VMZW@28216|Betaproteobacteria	28216|Betaproteobacteria	L	DNA polymerase family A	-	-	2.7.7.7	ko:K02334	-	-	-	-	ko00000,ko01000	-	-	-	DNA_pol_A
k59_407061_2	29581.BW37_00660	2.39e-44	157.0	COG0438@1|root,COG0438@2|Bacteria,1MY5T@1224|Proteobacteria,2VK2I@28216|Betaproteobacteria,476TS@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
k59_935178_1	446466.Cfla_2486	6.86e-84	259.0	COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria,4F13G@85016|Cellulomonadaceae	201174|Actinobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	GO:0008150,GO:0040007	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_113508_1	933262.AXAM01000013_gene1287	1.37e-65	212.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,42MG2@68525|delta/epsilon subdivisions,2WJ01@28221|Deltaproteobacteria,2MIUK@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_113510_1	1463854.JOHT01000016_gene6978	1.16e-53	181.0	COG1112@1|root,COG1112@2|Bacteria	2|Bacteria	L	Superfamily I DNA and RNA helicases and helicase subunits	-	-	-	ko:K14326	ko03013,ko03015,map03013,map03015	M00430	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	AAA_11,AAA_12
k59_1680517_1	426355.Mrad2831_0354	1.14e-114	349.0	COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2TRRK@28211|Alphaproteobacteria,1JR1Y@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	PFAM Coenzyme A transferase	pct	-	2.8.3.1	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	-	R00928,R01449,R05508	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_1346894_1	713586.KB900536_gene2551	8.27e-69	229.0	COG1538@1|root,COG1538@2|Bacteria,1RDNB@1224|Proteobacteria,1S535@1236|Gammaproteobacteria,1WXQ5@135613|Chromatiales	135613|Chromatiales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_563942_1	1463820.JOGW01000005_gene3303	1.27e-80	251.0	COG1960@1|root,COG1960@2|Bacteria,2GM3V@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7,1.3.8.8	ko:K00249,ko:K00255	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1102170_2	2340.JV46_18900	5.64e-67	206.0	COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,1S343@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Pfam Rhodanese-like	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1210311_3	706587.Desti_1914	4.61e-10	59.7	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42N5J@68525|delta/epsilon subdivisions,2WJ6B@28221|Deltaproteobacteria,2MR3T@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Cysteine-rich domain	bamD	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8
k59_505420_1	314278.NB231_13021	4.46e-54	191.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1WXIK@135613|Chromatiales	135613|Chromatiales	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_935194_1	314278.NB231_13006	1.01e-71	229.0	COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,1RRRE@1236|Gammaproteobacteria,1WVUP@135613|Chromatiales	135613|Chromatiales	M	Lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_113523_1	926569.ANT_25050	3.57e-91	285.0	COG0443@1|root,COG0443@2|Bacteria,2G5U5@200795|Chloroflexi	200795|Chloroflexi	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_1875139_1	1379698.RBG1_1C00001G0777	4.93e-64	220.0	COG2864@1|root,COG2864@2|Bacteria,2NQFM@2323|unclassified Bacteria	2|Bacteria	P	Prokaryotic cytochrome b561	cbcY	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C7,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese
k59_1445549_1	1123392.AQWL01000003_gene141	2.4e-83	259.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,2VJGA@28216|Betaproteobacteria	28216|Betaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K21834	-	-	-	-	ko00000	-	-	-	CCG,DUF3483,Fer4_8
k59_1680526_2	1198232.CYCME_0689	6.35e-15	72.8	COG0515@1|root,COG0515@2|Bacteria,1QU0D@1224|Proteobacteria,1T58D@1236|Gammaproteobacteria,462EW@72273|Thiotrichales	72273|Thiotrichales	KLT	Lipopolysaccharide kinase (Kdo/WaaP) family	-	-	-	-	-	-	-	-	-	-	-	-	Kdo
k59_1029178_2	1167006.UWK_02665	1.31e-59	194.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,42M26@68525|delta/epsilon subdivisions,2WN8V@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	S	TIGRFAM polyphosphate kinase 2, PA0141 family	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
k59_55355_1	690850.Desaf_3195	8.97e-07	55.8	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,42P4T@68525|delta/epsilon subdivisions,2WKBS@28221|Deltaproteobacteria,2M8DW@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
k59_1385831_1	1384056.N787_12755	2.23e-09	60.8	COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,1X3Z7@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyltransferase	aas	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase,MFS_1
k59_168556_1	506534.Rhein_1905	1.55e-53	177.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RN4D@1236|Gammaproteobacteria,1WXPM@135613|Chromatiales	135613|Chromatiales	S	PFAM Alcohol dehydrogenase	-	-	-	ko:K12957,ko:K13979	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_344055_1	1123360.thalar_02885	8.29e-127	379.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2U068@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_1225191_1	1386089.N865_06160	1.66e-83	258.0	COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,2GKB8@201174|Actinobacteria,4FFXJ@85021|Intrasporangiaceae	201174|Actinobacteria	P	TrkA-N domain	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
k59_804180_1	305900.GV64_15940	5.24e-67	211.0	COG1136@1|root,COG1136@2|Bacteria,1RA1K@1224|Proteobacteria,1S275@1236|Gammaproteobacteria,1XJGH@135619|Oceanospirillales	135619|Oceanospirillales	V	ABC transporter ATP-binding protein	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_804180_2	1129794.C427_5395	1.45e-05	46.2	COG4206@1|root,COG4206@2|Bacteria,1MUZG@1224|Proteobacteria,1RP7I@1236|Gammaproteobacteria,463Z2@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
k59_873241_1	1492922.GY26_07005	4.94e-06	49.7	COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,1SD1K@1236|Gammaproteobacteria,1J702@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TerB
k59_873241_2	342451.SSP0435	2.12e-12	68.2	COG2978@1|root,COG2978@2|Bacteria,1TPDU@1239|Firmicutes,4HAWR@91061|Bacilli,4GWWM@90964|Staphylococcaceae	91061|Bacilli	H	transporter	ydaH	-	-	ko:K12942	-	-	-	-	ko00000	-	-	-	ABG_transport
k59_577083_1	485913.Krac_2215	5.39e-46	163.0	COG4552@1|root,COG4552@2|Bacteria,2G7MV@200795|Chloroflexi	200795|Chloroflexi	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9
k59_1400065_1	1122197.ATWI01000008_gene2569	6.27e-45	150.0	COG1522@1|root,COG1522@2|Bacteria,1RIKY@1224|Proteobacteria,1S8HH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	heme biosynthesis protein	nirG	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
k59_695973_1	713587.THITH_07390	8.28e-46	169.0	COG0457@1|root,COG0457@2|Bacteria,1QZTW@1224|Proteobacteria,1T54Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
k59_695973_2	1267534.KB906754_gene3612	1.11e-15	82.0	COG0457@1|root,COG0457@2|Bacteria,3Y3VT@57723|Acidobacteria,2JHXZ@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_1400069_1	794846.AJQU01000069_gene1763	6.68e-31	124.0	COG1757@1|root,COG1757@2|Bacteria,1MVDF@1224|Proteobacteria,2TU82@28211|Alphaproteobacteria,4BIYY@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Na+/H+ antiporter family	-	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
k59_1046005_1	344747.PM8797T_12413	3.43e-48	166.0	COG1045@1|root,COG1045@2|Bacteria,2IX5K@203682|Planctomycetes	203682|Planctomycetes	E	COG1045 Serine acetyltransferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep
k59_1046030_1	1449049.JONW01000005_gene1171	5.17e-68	219.0	COG2911@1|root,COG2911@2|Bacteria,1NHQB@1224|Proteobacteria,2TZ4U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Porin_2
k59_1634767_2	765911.Thivi_3674	1.61e-16	76.3	2ESJH@1|root,33K45@2|Bacteria,1NI65@1224|Proteobacteria,1T0T6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2
k59_1400096_2	1163617.SCD_n02200	1.83e-146	439.0	COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,2VIK1@28216|Betaproteobacteria	28216|Betaproteobacteria	U	SMART AAA ATPase	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
k59_1576684_1	472759.Nhal_1608	1.1e-40	148.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RM9E@1236|Gammaproteobacteria,1WXRI@135613|Chromatiales	135613|Chromatiales	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
k59_873292_1	471853.Bcav_3154	6.32e-123	384.0	COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1225256_1	622637.KE124774_gene3663	1.27e-59	197.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2TSW4@28211|Alphaproteobacteria,370D9@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_636158_1	1415780.JPOG01000001_gene1094	1.06e-34	141.0	COG0664@1|root,COG1033@1|root,COG0664@2|Bacteria,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1X3P5@135614|Xanthomonadales	135614|Xanthomonadales	T	Sterol-sensing domain of SREBP cleavage-activation	-	-	-	-	-	-	-	-	-	-	-	-	MMPL,cNMP_binding
k59_226643_1	1237149.C900_05108	0.000267	49.3	COG1413@1|root,COG1413@2|Bacteria,4PKPI@976|Bacteroidetes,47NQS@768503|Cytophagia	976|Bacteroidetes	C	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,cNMP_binding
k59_344126_1	555779.Dthio_PD2017	1.56e-16	82.4	COG0500@1|root,COG1047@1|root,COG1047@2|Bacteria,COG2226@2|Bacteria,1PCH2@1224|Proteobacteria,42M58@68525|delta/epsilon subdivisions,2WK5Z@28221|Deltaproteobacteria,2MA7K@213115|Desulfovibrionales	28221|Deltaproteobacteria	OQ	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_517732_1	1047013.AQSP01000114_gene705	1.65e-61	199.0	COG3385@1|root,COG3385@2|Bacteria,2NQNF@2323|unclassified Bacteria	2|Bacteria	L	Domain of unknown function (DUF4372)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_696027_1	933262.AXAM01000008_gene1935	3.63e-37	141.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria,2MJ96@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_1634812_1	1140.Synpcc7942_1885	7.58e-43	150.0	COG0637@1|root,COG0637@2|Bacteria,1G2T2@1117|Cyanobacteria,1GZ2D@1129|Synechococcus	1117|Cyanobacteria	S	HAD-superfamily hydrolase subfamily IA, variant 3	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_577145_1	1034769.KB910518_gene4530	9.16e-32	127.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,4HBZC@91061|Bacilli,26SRH@186822|Paenibacillaceae	91061|Bacilli	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
k59_636180_1	449447.MAE_29810	2.18e-54	184.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1G175@1117|Cyanobacteria	1117|Cyanobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_228242_2	1121035.AUCH01000006_gene680	6.69e-63	200.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,2VSQ7@28216|Betaproteobacteria,2KW3W@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_578552_1	585531.HMPREF0063_12440	7.89e-11	60.8	COG2050@1|root,COG2050@2|Bacteria,2IJGG@201174|Actinobacteria,4DQPJ@85009|Propionibacteriales	201174|Actinobacteria	Q	Domain of unknown function (DUF4442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4442
k59_1227066_1	519989.ECTPHS_08773	2.11e-157	460.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1WXBH@135613|Chromatiales	135613|Chromatiales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_1697358_1	246200.SPO3036	3.09e-75	245.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria,4ND2Q@97050|Ruegeria	28211|Alphaproteobacteria	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_1636567_1	1122611.KB903939_gene626	2.52e-65	224.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria,4EI5W@85012|Streptosporangiales	201174|Actinobacteria	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_875301_1	1541065.JRFE01000058_gene5514	1.8e-82	266.0	COG1523@1|root,COG1523@2|Bacteria,1G0PW@1117|Cyanobacteria,3VIKJ@52604|Pleurocapsales	1117|Cyanobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_1807926_1	641491.DND132_1149	3.37e-54	191.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2M817@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family	bepE	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_228276_1	1163409.UUA_17827	4.36e-55	182.0	COG0274@1|root,COG0274@2|Bacteria,1N8AG@1224|Proteobacteria,1RPTS@1236|Gammaproteobacteria,1X5DR@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	-	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
k59_1401939_1	1035308.AQYY01000001_gene3334	6.53e-16	84.3	COG1404@1|root,COG2340@1|root,COG3209@1|root,COG1404@2|Bacteria,COG2340@2|Bacteria,COG3209@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,261EE@186807|Peptococcaceae	186801|Clostridia	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Cohesin,Peptidase_S8,SLH
k59_805646_1	880072.Desac_2345	1.39e-63	218.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MR9P@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Hydrophobe amphiphile Efflux-1 (HAE1) family	-	-	-	ko:K03296,ko:K19594	-	M00768,M00769	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.25,2.A.6.2.34	-	-	ACR_tran
k59_1807935_2	1403948.Q618_VCMC00001G0997	4.71e-14	76.3	COG0457@1|root,COG0647@1|root,COG0457@2|Bacteria,COG0647@2|Bacteria,2GK7V@201174|Actinobacteria,4D41R@85005|Actinomycetales	201174|Actinobacteria	G	HAD hydrolase, family IIA	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
k59_228285_1	1049564.TevJSym_ba00350	1.46e-85	278.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J595@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	cation transport ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_697572_1	876044.IMCC3088_2044	6.81e-78	249.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,1RQK5@1236|Gammaproteobacteria,1J4SZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_1461820_2	1218075.BAYA01000010_gene3253	3.64e-89	274.0	COG0697@1|root,COG0697@2|Bacteria,1MXJ6@1224|Proteobacteria,2VIA7@28216|Betaproteobacteria,1K5U4@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1048100_1	1035308.AQYY01000002_gene373	1.01e-10	61.6	COG0385@1|root,COG0385@2|Bacteria	2|Bacteria	S	bile acid:sodium symporter activity	-	-	-	ko:K14347	-	-	-	-	ko00000,ko02000,ko04147	2.A.93.1	-	-	SBF_like
k59_1048100_2	1170318.PALO_03335	2.29e-17	84.7	COG0330@1|root,COG0330@2|Bacteria,2GJ1U@201174|Actinobacteria,4DN0Q@85009|Propionibacteriales	201174|Actinobacteria	O	prohibitin homologues	hflK	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7
k59_461383_1	237368.SCABRO_01185	8.85e-44	160.0	COG1629@1|root,COG4771@2|Bacteria,2J47W@203682|Planctomycetes	203682|Planctomycetes	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	TonB_dep_Rec
k59_1461830_1	521393.JH806632_gene1172	3.67e-41	152.0	COG0642@1|root,COG2205@2|Bacteria,2GIV9@201174|Actinobacteria,4D3DY@85005|Actinomycetales	201174|Actinobacteria	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	phoR	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_170349_1	765912.Thimo_3624	7.9e-114	343.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1WXE8@135613|Chromatiales	135613|Chromatiales	S	PFAM Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_345736_1	880072.Desac_2183	5.32e-111	330.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WJ0U@28221|Deltaproteobacteria,2MQ46@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_578632_1	1229909.NSED_07970	5.72e-89	263.0	COG0100@1|root,arCOG04240@2157|Archaea,41SII@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Located on the platform of the 30S subunit	rps11	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
k59_1578620_1	530564.Psta_1819	3.21e-80	249.0	COG0560@1|root,COG0560@2|Bacteria,2IXZ0@203682|Planctomycetes	203682|Planctomycetes	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
k59_875366_1	1122201.AUAZ01000017_gene2914	8.6e-30	116.0	COG0470@1|root,COG0470@2|Bacteria,1R9U1@1224|Proteobacteria,1T1C8@1236|Gammaproteobacteria,46D20@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	DNA polymerase III, delta subunit	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
k59_345740_1	89187.ISM_15585	8.36e-23	99.8	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2TR46@28211|Alphaproteobacteria,46PE5@74030|Roseovarius	28211|Alphaproteobacteria	T	COG0642 Signal transduction histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8
k59_345747_1	2340.JV46_26710	7.71e-47	153.0	2AB8D@1|root,310NU@2|Bacteria,1RFGC@1224|Proteobacteria,1S5A2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1161246_1	471853.Bcav_0773	6.57e-84	249.0	COG1329@1|root,COG1329@2|Bacteria,2GKSU@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	carD	GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0040007,GO:0042594,GO:0044419,GO:0050896,GO:0051704,GO:0051716,GO:0071496	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
k59_228353_1	272559.BF9343_1579	2.13e-09	57.8	COG0021@1|root,COG0021@2|Bacteria,4P14U@976|Bacteroidetes,2FN0P@200643|Bacteroidia,4AKPQ@815|Bacteroidaceae	976|Bacteroidetes	H	Belongs to the transketolase family	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_228353_2	1380600.AUYN01000001_gene2466	4.49e-07	52.8	COG3264@1|root,COG3264@2|Bacteria,4NEAM@976|Bacteroidetes,1HYUA@117743|Flavobacteriia	976|Bacteroidetes	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_1753401_1	765912.Thimo_1338	1.86e-189	535.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,1WXK9@135613|Chromatiales	135613|Chromatiales	C	Belongs to the heme-copper respiratory oxidase family	-	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_757404_2	631362.Thi970DRAFT_04763	8.77e-25	101.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RMF2@1236|Gammaproteobacteria,1X0ZR@135613|Chromatiales	135613|Chromatiales	O	HflC and HflK could regulate a protease	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_228361_1	177437.HRM2_30690	1.38e-45	158.0	COG1387@1|root,COG1387@2|Bacteria,1MX8T@1224|Proteobacteria,43BI2@68525|delta/epsilon subdivisions,2WMD5@28221|Deltaproteobacteria,2MII3@213118|Desulfobacterales	28221|Deltaproteobacteria	E	histidinol phosphate phosphatase HisJ family	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
k59_1161259_1	1437824.BN940_03426	2.89e-63	218.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,3T2UZ@506|Alcaligenaceae	28216|Betaproteobacteria	C	FAD linked oxidase, C-terminal domain-containing protein 6	glpCD	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_875413_1	261292.Nit79A3_3464	7.48e-40	150.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2VJSI@28216|Betaproteobacteria,372PZ@32003|Nitrosomonadales	28216|Betaproteobacteria	L	RNA polymerase recycling family C-terminal	-	-	-	ko:K03580	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	DUF3883,Helicase_C,RapA_C,ResIII,SNF2_N
k59_875419_1	1454004.AW11_01551	1.54e-14	73.6	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,2VJGQ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the UPF0753 family	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k59_345781_2	1415166.NONO_c57570	4.01e-42	150.0	COG1104@1|root,COG1104@2|Bacteria,2GKUT@201174|Actinobacteria,4FU5U@85025|Nocardiaceae	201174|Actinobacteria	E	Cysteine desulfurase	iscS	GO:0003674,GO:0003824,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0022607,GO:0031071,GO:0031163,GO:0040007,GO:0044085,GO:0044237,GO:0051186,GO:0071840	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_1578689_1	471853.Bcav_1967	3.69e-56	180.0	2AQ7N@1|root,31FDD@2|Bacteria,2IFXR@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1578689_2	471853.Bcav_1966	3.12e-60	201.0	COG3919@1|root,COG3919@2|Bacteria,2GM4D@201174|Actinobacteria	201174|Actinobacteria	V	ATP-grasp	-	-	6.3.1.12	ko:K17810	-	-	-	-	ko00000,ko01000	-	-	-	CPSase_L_D2
k59_1697507_1	478741.JAFS01000002_gene872	4.16e-38	144.0	COG1519@1|root,COG1519@2|Bacteria,46SK9@74201|Verrucomicrobia,37G30@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N
k59_1048193_1	583355.Caka_2045	4.85e-20	96.7	COG0771@1|root,COG2911@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	murD	-	3.4.21.10,6.3.2.13,6.3.2.9	ko:K01317,ko:K01925,ko:K01928,ko:K01932	ko00300,ko00471,ko00550,ko01100,map00300,map00471,map00550,map01100	-	R02783,R02788	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01002,ko01011,ko04131	-	-	-	DUF1727,Mur_ligase_C,Mur_ligase_M
k59_1636679_1	1047013.AQSP01000083_gene1189	7.65e-32	122.0	COG1459@1|root,COG1459@2|Bacteria,2NP2J@2323|unclassified Bacteria	2|Bacteria	U	Type II secretion system (T2SS), protein F	pilC	-	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
k59_1061139_1	340177.Cag_0616	7.55e-15	81.3	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Big_3_2,CHU_C,Flg_new,LRR_5
k59_1236948_1	706587.Desti_0217	2.26e-69	230.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42MQJ@68525|delta/epsilon subdivisions,2WJIX@28221|Deltaproteobacteria,2MR3H@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
k59_1061142_1	290340.AAur_1356	2.3e-14	73.9	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,1W8GA@1268|Micrococcaceae	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1354239_1	1121106.JQKB01000010_gene489	2.06e-62	215.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JPMJ@204441|Rhodospirillales	204441|Rhodospirillales	V	COG0841 Cation multidrug efflux pump	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_121513_1	265072.Mfla_1003	2.82e-33	130.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,2KKP9@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_766705_1	395961.Cyan7425_2548	2.23e-16	83.6	COG1262@1|root,COG4301@1|root,COG1262@2|Bacteria,COG4301@2|Bacteria,1G2JI@1117|Cyanobacteria,3KFTD@43988|Cyanothece	1117|Cyanobacteria	S	TIGRFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
k59_297737_1	522306.CAP2UW1_2245	5.21e-120	366.0	28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,2VMEK@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Pfam Fatty acid	cti	-	-	-	-	-	-	-	-	-	-	-	CTI
k59_886781_1	349521.HCH_06589	4.36e-42	153.0	COG0845@1|root,COG0845@2|Bacteria,1R443@1224|Proteobacteria,1S3AT@1236|Gammaproteobacteria,1XPIS@135619|Oceanospirillales	135619|Oceanospirillales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_1178129_1	1049564.TevJSym_ab00850	7.14e-170	491.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1J52C@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation	deaD	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010501,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019439,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0032268,GO:0032270,GO:0033554,GO:0033592,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034655,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043170,GO:0043487,GO:0043488,GO:0043489,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045934,GO:0046483,GO:0046700,GO:0048255,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070035,GO:0070417,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097617,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902369,GO:1902373,GO:1903311,GO:1903312,GO:2000112	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DEADboxA,DbpA,Helicase_C
k59_1297834_1	983545.Glaag_1384	1.56e-85	259.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,465HR@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	COG0811 Biopolymer transport proteins	tolQ	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0017038,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0033036,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
k59_5450_1	717785.HYPMC_2367	5.54e-41	139.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2U99J@28211|Alphaproteobacteria,3N71D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	GO:0003674,GO:0003824,GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
k59_5450_2	582899.Hden_1129	1.22e-16	80.5	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2TSI7@28211|Alphaproteobacteria,3N752@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Cytochrome c-type biogenesis protein	cycH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_19
k59_1471643_1	1123504.JQKD01000032_gene4501	1.83e-44	156.0	COG2203@1|root,COG2203@2|Bacteria,1PP8V@1224|Proteobacteria,2VKHH@28216|Betaproteobacteria,4ACU3@80864|Comamonadaceae	28216|Betaproteobacteria	T	Pfam:Pyridox_oxidase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF_2,Putative_PNPOx
k59_1764913_1	1049564.TevJSym_bo00180	3.11e-37	128.0	COG3794@1|root,COG3794@2|Bacteria,1N889@1224|Proteobacteria,1SEU6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
k59_1764913_2	1122197.ATWI01000008_gene2565	2.75e-54	186.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,1RR3N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG2010 Cytochrome c, mono- and diheme variants	nirN	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_358496_1	420324.KI912026_gene5046	1.61e-95	313.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,1JR2R@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,HemolysinCabind,Peptidase_S8,W_rich_C
k59_1764919_1	519989.ECTPHS_05646	2.03e-28	110.0	COG1843@1|root,COG1843@2|Bacteria,1MXCG@1224|Proteobacteria,1RPZI@1236|Gammaproteobacteria,1WY90@135613|Chromatiales	135613|Chromatiales	N	Required for flagellar hook formation. May act as a scaffolding protein	-	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FLgD_tudor,FlgD,FlgD_ig
k59_1764919_2	90814.KL370891_gene663	2.8e-17	76.3	COG1558@1|root,COG1558@2|Bacteria,1RHI3@1224|Proteobacteria,1S653@1236|Gammaproteobacteria,460W1@72273|Thiotrichales	72273|Thiotrichales	N	Belongs to the flagella basal body rod proteins family	-	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
k59_1588756_1	1386089.N865_03045	3.82e-64	215.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,2GKQ8@201174|Actinobacteria,4FF5S@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_tranf_2_3,Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2
k59_65016_1	95619.PM1_0229040	4.23e-80	245.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	chromosome partitioning	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_1178157_1	471853.Bcav_2655	3.99e-100	297.0	COG1949@1|root,COG1949@2|Bacteria,2GJR7@201174|Actinobacteria	201174|Actinobacteria	L	3'-to-5' exoribonuclease specific for small oligoribonucleotides	orn	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360	-	ko:K13288	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	RNase_T
k59_591280_1	399549.Msed_1425	1.41e-05	48.1	COG0517@1|root,arCOG00606@2157|Archaea,2XSRA@28889|Crenarchaeota	28889|Crenarchaeota	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_649879_1	13690.CP98_02093	7.4e-22	99.4	COG3577@1|root,COG3577@2|Bacteria,1MYAD@1224|Proteobacteria,2U9RE@28211|Alphaproteobacteria,2K4GD@204457|Sphingomonadales	204457|Sphingomonadales	S	gag-polyprotein putative aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,gag-asp_proteas
k59_1413058_1	1123517.JOMR01000001_gene73	5.91e-05	46.2	2DSZ4@1|root,33I02@2|Bacteria,1NGMX@1224|Proteobacteria,1SGFG@1236|Gammaproteobacteria,461C4@72273|Thiotrichales	72273|Thiotrichales	S	ATP synthase I chain	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATP-synt_I
k59_1413058_2	1123393.KB891332_gene2796	1.32e-102	305.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,1KRNA@119069|Hydrogenophilales	119069|Hydrogenophilales	C	ATP synthase A chain	-	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1648043_1	471853.Bcav_1908	1.6e-62	212.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_1826005_1	998674.ATTE01000001_gene4360	2.32e-107	340.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,461RZ@72273|Thiotrichales	72273|Thiotrichales	E	Putative amidoligase enzyme (DUF2126)	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
k59_1764933_1	768671.ThimaDRAFT_4169	1.59e-106	327.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,1WXFC@135613|Chromatiales	135613|Chromatiales	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1530201_1	356851.JOAN01000034_gene1743	6.27e-19	95.5	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,4D9CN@85008|Micromonosporales	201174|Actinobacteria	M	Exporter of polyketide	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
k59_591290_1	1304865.JAGF01000001_gene1363	1.32e-77	250.0	COG1232@1|root,COG1232@2|Bacteria,2GMMA@201174|Actinobacteria,4F0Z0@85016|Cellulomonadaceae	201174|Actinobacteria	H	Flavin containing amine oxidoreductase	hemG	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_1001630_1	365044.Pnap_3495	0.00012	48.1	COG3937@1|root,COG3937@2|Bacteria,1RIXG@1224|Proteobacteria,2VT1J@28216|Betaproteobacteria,4ADWD@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM poly granule associated family protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
k59_1764936_1	768066.HELO_1883	1.51e-09	58.9	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1XJ61@135619|Oceanospirillales	135619|Oceanospirillales	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
k59_1764936_2	1049564.TevJSym_as00740	7.78e-41	139.0	2BG6F@1|root,32A39@2|Bacteria,1RI4Y@1224|Proteobacteria,1S5H3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1471696_1	1265505.ATUG01000003_gene342	1.09e-79	263.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIJ3@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
k59_886863_1	754477.Q7C_1002	3.61e-30	118.0	COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,1RPDG@1236|Gammaproteobacteria,460CE@72273|Thiotrichales	72273|Thiotrichales	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_886863_2	713586.KB900536_gene406	9.79e-30	119.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,1WWBR@135613|Chromatiales	135613|Chromatiales	G	PFAM glycoside hydrolase, family 77	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_945710_1	96561.Dole_3027	2.94e-51	172.0	COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,42NE6@68525|delta/epsilon subdivisions,2WJ92@28221|Deltaproteobacteria,2MJ1B@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_2
k59_180226_1	1043493.BBLU01000018_gene1582	8.1e-58	191.0	COG1266@1|root,COG1266@2|Bacteria,2GYQG@201174|Actinobacteria	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_886867_1	935839.JAGJ01000005_gene2756	2e-167	478.0	COG0126@1|root,COG0126@2|Bacteria,2GJC6@201174|Actinobacteria,4F49B@85017|Promicromonosporaceae	201174|Actinobacteria	G	Phosphoglycerate kinase	pgk	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_5496_1	1123008.KB905701_gene2152	4.25e-21	94.4	28K3Q@1|root,2Z9ST@2|Bacteria,4NGK9@976|Bacteroidetes,2FRAP@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_5496_4	1250006.JHZZ01000001_gene2918	1.02e-26	116.0	2BFD6@1|root,3296M@2|Bacteria,4NQWY@976|Bacteroidetes,1I31C@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1413088_1	1385515.N791_05130	1.69e-31	120.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,1X3GV@135614|Xanthomonadales	135614|Xanthomonadales	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	cyoE	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_1413088_2	550540.Fbal_0192	1.9e-09	60.5	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,1RQWB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Cytochrome oxidase assembly	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
k59_1297920_2	1121015.N789_13885	1.77e-17	84.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,1S24R@1236|Gammaproteobacteria,1XCKR@135614|Xanthomonadales	135614|Xanthomonadales	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
k59_1354311_1	631362.Thi970DRAFT_00879	7.32e-58	182.0	COG1569@1|root,COG1569@2|Bacteria,1N1T4@1224|Proteobacteria,1SE91@1236|Gammaproteobacteria,1WZFG@135613|Chromatiales	135613|Chromatiales	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
k59_1354311_2	631362.Thi970DRAFT_00880	3.63e-38	129.0	2EG2X@1|root,339UW@2|Bacteria,1NCM8@1224|Proteobacteria,1T0FA@1236|Gammaproteobacteria,1WZTF@135613|Chromatiales	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HicB
k59_825705_1	768671.ThimaDRAFT_3222	8.17e-73	234.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1WWMF@135613|Chromatiales	135613|Chromatiales	O	PFAM Magnesium chelatase, ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_825705_2	768671.ThimaDRAFT_3221	3.53e-32	114.0	COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria,1SCH1@1236|Gammaproteobacteria,1WYUC@135613|Chromatiales	135613|Chromatiales	S	Membrane fusogenic activity	-	-	-	ko:K09806	-	-	-	-	ko00000	-	-	-	BMFP
k59_825705_3	1163407.UU7_09475	5.16e-10	61.6	2C5U9@1|root,2Z9NJ@2|Bacteria,1R8VZ@1224|Proteobacteria,1RWKX@1236|Gammaproteobacteria,1X5HZ@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
k59_180238_1	768671.ThimaDRAFT_2663	3.27e-90	271.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,1RMFR@1236|Gammaproteobacteria,1WWRE@135613|Chromatiales	135613|Chromatiales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
k59_65077_1	593907.Celgi_1958	3.58e-131	383.0	COG1350@1|root,COG1350@2|Bacteria,2GP7D@201174|Actinobacteria	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB2	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_591316_1	644966.Tmar_1896	1.8e-05	51.2	COG3547@1|root,COG3547@2|Bacteria,1VI3C@1239|Firmicutes,25AXZ@186801|Clostridia	186801|Clostridia	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1471725_1	1207063.P24_07989	5.77e-104	325.0	COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,2TW58@28211|Alphaproteobacteria,2JPP0@204441|Rhodospirillales	204441|Rhodospirillales	V	transporter, ATP-binding protein	-	-	-	ko:K13926	-	-	-	-	ko00000	-	-	-	ABC2_membrane_3,ABC_tran
k59_1413955_2	1123401.JHYQ01000001_gene1911	2.15e-45	152.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,1RPK3@1236|Gammaproteobacteria,460KW@72273|Thiotrichales	72273|Thiotrichales	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
k59_1002294_1	452652.KSE_71820	2.58e-25	107.0	COG2188@1|root,COG2188@2|Bacteria,2GJZ1@201174|Actinobacteria,2M29B@2063|Kitasatospora	201174|Actinobacteria	K	UTRA	phnF	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
k59_1413961_1	298655.KI912266_gene2722	1.95e-20	90.1	COG5395@1|root,COG5395@2|Bacteria,2IEUZ@201174|Actinobacteria	201174|Actinobacteria	S	Predicted membrane protein (DUF2306)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2306
k59_1413961_2	367299.JOEE01000001_gene1642	8.33e-15	72.4	COG0300@1|root,COG0300@2|Bacteria,2GKAJ@201174|Actinobacteria,4FI7N@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
k59_66154_1	452637.Oter_0670	7.66e-103	315.0	COG1053@1|root,COG1053@2|Bacteria,46S7D@74201|Verrucomicrobia,3K754@414999|Opitutae	414999|Opitutae	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1299065_1	1049564.TevJSym_ax00380	1.64e-102	310.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1J4IM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_3999	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
k59_1589512_1	202952.BBLI01000011_gene1091	1.66e-12	67.4	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,3NIMZ@468|Moraxellaceae	1236|Gammaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_1589512_2	402626.Rpic_3691	1.36e-26	100.0	COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2VUFB@28216|Betaproteobacteria,1K8M3@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
k59_1472831_1	643648.Slip_1606	1.69e-62	204.0	COG1484@1|root,COG1484@2|Bacteria,1UYIT@1239|Firmicutes,24DFX@186801|Clostridia,42KKU@68298|Syntrophomonadaceae	186801|Clostridia	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_1472831_2	1112216.JH594426_gene3799	3.36e-118	362.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2K2UN@204457|Sphingomonadales	204457|Sphingomonadales	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_240796_1	713587.THITH_07195	2.01e-137	402.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WW29@135613|Chromatiales	135613|Chromatiales	S	PFAM Uncharacterised protein family UPF0027	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_6902_2	543913.D521_0523	4e-24	100.0	COG3161@1|root,COG3161@2|Bacteria,1N8BF@1224|Proteobacteria,2VU5V@28216|Betaproteobacteria,1KR67@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway	ubiC	-	4.1.3.40	ko:K03181	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R01302	RC00491,RC02148	ko00000,ko00001,ko00002,ko01000	-	-	-	Chor_lyase
k59_6902_3	95619.PM1_0202915	6.47e-23	98.2	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_1119691_1	1304883.KI912532_gene953	4.15e-122	372.0	COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,2VIV2@28216|Betaproteobacteria,2KVXE@206389|Rhodocyclales	206389|Rhodocyclales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1062130_1	1386089.N865_01380	2.05e-154	446.0	COG3344@1|root,COG3344@2|Bacteria,2GUJS@201174|Actinobacteria	201174|Actinobacteria	L	RNA-directed DNA polymerase (reverse transcriptase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_415673_1	1049564.TevJSym_ab01230	1.8e-91	275.0	COG2242@1|root,COG2242@2|Bacteria,1R79F@1224|Proteobacteria,1RY3Z@1236|Gammaproteobacteria,1J8AJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_181081_1	589865.DaAHT2_0263	2.8e-61	210.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42QM3@68525|delta/epsilon subdivisions,2WKI2@28221|Deltaproteobacteria,2MI4S@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lysin motif	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_650776_1	580332.Slit_2755	7.24e-12	63.9	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,2VWDY@28216|Betaproteobacteria,44VYI@713636|Nitrosomonadales	28216|Betaproteobacteria	S	DUF167	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
k59_650776_2	1158762.KB898051_gene860	1.11e-19	86.7	2DP15@1|root,3303T@2|Bacteria,1N7NN@1224|Proteobacteria,1S90P@1236|Gammaproteobacteria,1WZKG@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4426)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4426
k59_474583_1	553973.CLOHYLEM_05143	3.99e-06	48.1	COG2243@1|root,COG2243@2|Bacteria,1TP87@1239|Firmicutes,249DM@186801|Clostridia,2203A@1506553|Lachnoclostridium	186801|Clostridia	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	cobI	-	2.1.1.130,2.1.1.151	ko:K03394	ko00860,ko01100,map00860,map01100	-	R03948,R05808	RC00003,RC01035,RC01662	ko00000,ko00001,ko01000	-	-	-	TP_methylase
k59_474583_2	526222.Desal_2304	2.53e-44	154.0	COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,42PQA@68525|delta/epsilon subdivisions,2WNUY@28221|Deltaproteobacteria,2M887@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
k59_66203_1	1346791.M529_01275	4.48e-19	92.0	COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,1MXH9@1224|Proteobacteria,2TUMC@28211|Alphaproteobacteria,2K1W7@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterised conserved protein (DUF2156)	-	-	2.3.2.3	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504	2.A.1.3.37	-	-	DUF2156,LPG_synthase_TM
k59_1070938_2	1196835.A458_19805	8.54e-05	45.8	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1Z0JM@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_480472_1	1121943.KB899991_gene2507	1.98e-67	207.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1XK33@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth,PRA-CH,PRA-PH
k59_480472_2	380703.AHA_1567	1.45e-27	107.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,1S22I@1236|Gammaproteobacteria,1Y49S@135624|Aeromonadales	135624|Aeromonadales	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
k59_368086_1	1225184.ALXE01000019_gene4235	5.53e-52	174.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,3VYRF@53335|Pantoea	1236|Gammaproteobacteria	E	forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	iECSF_1327.ECSF_1909	HisG,HisG_C
k59_304313_1	1451261.AS96_00295	1.51e-47	175.0	COG1674@1|root,COG1716@1|root,COG1674@2|Bacteria,COG1716@2|Bacteria,2GJBR@201174|Actinobacteria,4FKDQ@85023|Microbacteriaceae	201174|Actinobacteria	DT	FtsK/SpoIIIE family	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FHA,FtsK_SpoIIIE,Yop-YscD_cpl
k59_715722_1	1121898.Q766_20710	2.02e-05	52.0	COG3291@1|root,COG3291@2|Bacteria,4NDZQ@976|Bacteroidetes,1HX5A@117743|Flavobacteriia,2NSSE@237|Flavobacterium	976|Bacteroidetes	O	gliding motility-associated C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,PKD
k59_252355_1	1121405.dsmv_3251	1.93e-108	337.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2MHZG@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
k59_1246488_2	497964.CfE428DRAFT_1024	2.53e-35	125.0	2EBIG@1|root,335IZ@2|Bacteria,46WF8@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_896365_1	319224.Sputcn32_3956	2.13e-108	324.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,2Q9JN@267890|Shewanellaceae	1236|Gammaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	e_coli_core.b3732,iAF1260.b3732,iAPECO1_1312.APECO1_2729,iB21_1397.B21_03560,iBWG_1329.BWG_3423,iE2348C_1286.E2348C_4042,iEC042_1314.EC042_4119,iEC55989_1330.EC55989_4207,iECABU_c1320.ECABU_c42160,iECBD_1354.ECBD_4300,iECB_1328.ECB_03616,iECDH10B_1368.ECDH10B_3919,iECDH1ME8569_1439.ECDH1ME8569_3620,iECD_1391.ECD_03616,iECED1_1282.ECED1_4422,iECH74115_1262.ECH74115_5168,iECIAI1_1343.ECIAI1_3916,iECIAI39_1322.ECIAI39_4336,iECNA114_1301.ECNA114_3881,iECO103_1326.ECO103_4426,iECO111_1330.ECO111_4566,iECO26_1355.ECO26_4846,iECOK1_1307.ECOK1_4181,iECP_1309.ECP_3931,iECS88_1305.ECS88_4154,iECSE_1348.ECSE_4022,iECSF_1327.ECSF_3580,iECSP_1301.ECSP_4782,iECUMN_1333.ECUMN_4262,iECW_1372.ECW_m4035,iECs_1301.ECs4674,iEKO11_1354.EKO11_4613,iETEC_1333.ETEC_4023,iEcDH1_1363.EcDH1_4235,iEcE24377_1341.EcE24377A_4247,iEcSMS35_1347.EcSMS35_4100,iEcolC_1368.EcolC_4262,iG2583_1286.G2583_4528,iJO1366.b3732,iJR904.b3732,iLF82_1304.LF82_0194,iNRG857_1313.NRG857_18585,iPC815.YPO4121,iSFV_1184.SFV_3758,iSF_1195.SF3812,iSFxv_1172.SFxv_4154,iSSON_1240.SSON_3887,iS_1188.S3956,iSbBS512_1146.SbBS512_E4189,iUMN146_1321.UM146_18850,iUMNK88_1353.UMNK88_4544,iUTI89_1310.UTI89_C4285,iWFL_1372.ECW_m4035,iY75_1357.Y75_RS18410,iZ_1308.Z5230,ic_1306.c4658	ATP-synt_ab,ATP-synt_ab_N
k59_772355_1	886379.AEWI01000010_gene628	5.11e-54	186.0	COG4624@1|root,COG4624@2|Bacteria,4NFXC@976|Bacteroidetes,2FP4U@200643|Bacteroidia,3XJD3@558415|Marinilabiliaceae	976|Bacteroidetes	C	Putative Fe-S cluster	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_10
k59_1070957_1	1123065.ATWL01000032_gene3399	4.02e-102	299.0	COG1432@1|root,COG1432@2|Bacteria,2GMV5@201174|Actinobacteria	201174|Actinobacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
k59_1655316_1	391038.Bphy_2301	6e-23	107.0	2AHB9@1|root,317MQ@2|Bacteria,1PYZ8@1224|Proteobacteria,2WE3A@28216|Betaproteobacteria,1KBIU@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_1655316_2	1380347.JNII01000007_gene406	8.71e-46	161.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_597683_1	644284.Arch_1433	2.25e-136	400.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4D45E@85005|Actinomycetales	201174|Actinobacteria	H	Belongs to the citrate synthase family	gltA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_832920_1	177437.HRM2_47440	8.57e-62	214.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WISW@28221|Deltaproteobacteria,2MIUG@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1307505_1	349102.Rsph17025_0014	9.95e-22	97.4	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,1FBKS@1060|Rhodobacter	28211|Alphaproteobacteria	S	PAN domain	MA20_30110	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,PAN_1,Thiol-ester_cl
k59_1307505_2	663610.JQKO01000017_gene1666	6.12e-20	89.7	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,2TR2R@28211|Alphaproteobacteria,3NA2Z@45404|Beijerinckiaceae	28211|Alphaproteobacteria	M	Penicillin-Binding Protein C-terminus Family	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
k59_539321_1	880072.Desac_1622	1.04e-128	373.0	COG2221@1|root,COG2221@2|Bacteria,1MVZQ@1224|Proteobacteria,42N7B@68525|delta/epsilon subdivisions,2WJYE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM sulfite reductase, dissimilatory-type beta subunit	dsrB	-	1.8.99.5	ko:K11181	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7,NIR_SIR,NIR_SIR_ferr
k59_128774_1	1249627.D779_1497	3.37e-28	111.0	COG1249@1|root,COG1249@2|Bacteria,1MVVE@1224|Proteobacteria,1RMJT@1236|Gammaproteobacteria,1WWC2@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	sthA	-	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_128774_2	396588.Tgr7_0259	8.42e-42	154.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1WXPW@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
k59_1655324_1	471853.Bcav_1246	1.01e-184	542.0	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_657090_1	1280952.HJA_13220	1.25e-92	288.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases	MA20_01050	-	1.17.1.10	ko:K15022	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00377	R00134	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3
k59_1307520_1	1410619.SRDD_03460	3.23e-38	147.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1RWPP@1236|Gammaproteobacteria,401ZW@613|Serratia	1236|Gammaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,Hpt,PAS_3,Response_reg
k59_539327_2	314278.NB231_10954	1.56e-31	118.0	2E05E@1|root,32VTR@2|Bacteria,1N5CW@1224|Proteobacteria,1S8Y5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_128783_1	1366046.HIMB11_01542	3.34e-92	280.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,3ZH54@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	C	COG1960 Acyl-CoA dehydrogenases	MA20_27425	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_368134_1	1382304.JNIL01000001_gene2138	9.59e-12	68.6	COG5421@1|root,COG5421@2|Bacteria,1TPAA@1239|Firmicutes,4HDFR@91061|Bacilli	91061|Bacilli	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1360857_1	998088.B565_0506	5.56e-86	268.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1Y43R@135624|Aeromonadales	135624|Aeromonadales	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
k59_1712927_2	857087.Metme_1494	7.58e-79	255.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1XEH5@135618|Methylococcales	135618|Methylococcales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_481263_2	998674.ATTE01000001_gene1321	2.38e-25	104.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,460VE@72273|Thiotrichales	72273|Thiotrichales	S	Sodium:solute symporter family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_1537626_1	626887.J057_06306	4.15e-65	214.0	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,1SZCP@1236|Gammaproteobacteria,46CY1@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_188248_1	1357272.AVEO02000111_gene3559	1.24e-40	139.0	COG5611@1|root,COG5611@2|Bacteria,1PD30@1224|Proteobacteria,1SHWJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
k59_657874_1	935863.AWZR01000004_gene491	5.32e-27	108.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,1RN2U@1236|Gammaproteobacteria,1X4FJ@135614|Xanthomonadales	135614|Xanthomonadales	C	oxidase, subunit	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_1072214_1	640511.BC1002_5732	4.28e-111	328.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria,1K4KX@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_305087_1	743718.Isova_2157	2.03e-75	249.0	COG4581@1|root,COG4581@2|Bacteria,2GJSV@201174|Actinobacteria,4F3M6@85017|Promicromonosporaceae	201174|Actinobacteria	L	Domain of unknown function (DUF3516)	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,DUF3516,Helicase_C
k59_833688_1	177437.HRM2_15160	2.09e-33	132.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,2MMPS@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	actB	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1537628_1	1123377.AUIV01000005_gene1695	2.44e-11	63.9	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1X2YR@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_1537628_2	1288826.MSNKSG1_00216	7.36e-33	124.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,464WM@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispA	GO:0003674,GO:0003824,GO:0004161,GO:0004337,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033383,GO:0033384,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045337,GO:0045338,GO:0071704,GO:0090407,GO:1901576	2.5.1.1,2.5.1.10,2.5.1.29	ko:K00795,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iPC815.YPO3176,iSFV_1184.SFV_0386	polyprenyl_synt
k59_772987_1	316067.Geob_2362	6.87e-55	182.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,42S4S@68525|delta/epsilon subdivisions,2WNIV@28221|Deltaproteobacteria,43S1H@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	cytidylate kinase activity	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
k59_1186354_2	1385519.N801_07640	8.62e-08	51.6	COG0346@1|root,COG0346@2|Bacteria,2IRGK@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_598418_2	1120948.KB903221_gene401	1.3e-07	52.8	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria,4E1SM@85010|Pseudonocardiales	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1772127_1	1267005.KB911255_gene2597	6.8e-69	220.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2TRUF@28211|Alphaproteobacteria,3N69P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_716508_1	362663.ECP_3973	2.68e-07	54.7	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,1S5WR@1236|Gammaproteobacteria,3XPPM@561|Escherichia	1236|Gammaproteobacteria	O	Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	iECW_1372.ECW_m4079,iECs_1301.ECs4714,iEKO11_1354.EKO11_4576,iG2583_1286.G2583_4574,iSBO_1134.SBO_3791,iSDY_1059.SDY_3968,iSF_1195.SF3854,iSSON_1240.SSON_3952,iS_1188.S3905,iWFL_1372.ECW_m4079,iZ_1308.Z5291	Thioredoxin
k59_1482679_1	1187851.A33M_4208	7.06e-82	258.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,3FCY5@34008|Rhodovulum	28211|Alphaproteobacteria	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2
k59_1421326_1	472759.Nhal_2720	3.28e-93	282.0	COG3219@1|root,COG3219@2|Bacteria,1R8C9@1224|Proteobacteria,1S23S@1236|Gammaproteobacteria,1WXZ1@135613|Chromatiales	135613|Chromatiales	S	Putative DNA-binding domain	-	-	-	ko:K09929	-	-	-	-	ko00000	-	-	-	DUF2063
k59_1421326_2	1121035.AUCH01000017_gene2261	4.26e-30	111.0	COG2259@1|root,COG2259@2|Bacteria,1RDRZ@1224|Proteobacteria,2VS2G@28216|Betaproteobacteria,2KYXS@206389|Rhodocyclales	206389|Rhodocyclales	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
k59_129568_1	1249627.D779_1527	9.01e-37	132.0	COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,1RPJT@1236|Gammaproteobacteria,1WXP4@135613|Chromatiales	135613|Chromatiales	P	ABC transporter	znuC	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
k59_129568_2	765913.ThidrDRAFT_2846	1.81e-11	63.9	COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,1T1Q3@1236|Gammaproteobacteria,1WXCI@135613|Chromatiales	135613|Chromatiales	P	PFAM periplasmic solute binding protein	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
k59_1836824_1	1115803.HMPREF1129_2372	9.49e-27	102.0	COG0717@1|root,COG0717@2|Bacteria,2GKQQ@201174|Actinobacteria,4D3KA@85005|Actinomycetales	201174|Actinobacteria	F	Belongs to the dCTP deaminase family	dcd	GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
k59_716513_1	870187.Thini_4246	4.01e-35	141.0	COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07673	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3
k59_540137_1	439235.Dalk_2651	3.44e-85	260.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42N1R@68525|delta/epsilon subdivisions,2WJ7R@28221|Deltaproteobacteria,2MHWB@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM cysteine synthase A	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1247640_1	1263831.F543_22830	6.1e-126	367.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria	1224|Proteobacteria	M	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_188273_1	335543.Sfum_3752	5.24e-25	107.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,42PCH@68525|delta/epsilon subdivisions,2WMQM@28221|Deltaproteobacteria,2MRKG@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM Three-deoxy-D-manno-octulosonic-acid transferase	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
k59_1482693_1	1278309.KB907099_gene2445	5.93e-34	119.0	COG0347@1|root,COG0347@2|Bacteria,1RI28@1224|Proteobacteria,1S62Z@1236|Gammaproteobacteria,1XK6I@135619|Oceanospirillales	135619|Oceanospirillales	K	Nitrogen regulatory protein P-II	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1072254_1	996637.SGM_5443	1.04e-08	61.6	COG0297@1|root,COG0297@2|Bacteria,2I2EE@201174|Actinobacteria	201174|Actinobacteria	G	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_1072254_2	935839.JAGJ01000011_gene412	1.57e-26	108.0	COG0438@1|root,COG0438@2|Bacteria,2ICB6@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_1596054_1	1120956.JHZK01000001_gene3483	6.58e-61	199.0	COG0491@1|root,COG0491@2|Bacteria,1MY6G@1224|Proteobacteria,2TSXC@28211|Alphaproteobacteria,1JPNP@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_188279_1	469383.Cwoe_1328	5.97e-80	264.0	COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria,4CP97@84995|Rubrobacteria	84995|Rubrobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_657907_1	573370.DMR_34710	8.96e-50	173.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,42M94@68525|delta/epsilon subdivisions,2WINB@28221|Deltaproteobacteria,2M8JZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_1537661_1	768671.ThimaDRAFT_2966	1.15e-70	233.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales	135613|Chromatiales	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_481300_1	2340.JV46_16140	5.01e-65	202.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1J5V2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_481300_2	686340.Metal_3321	4.23e-35	123.0	COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,1S5V7@1236|Gammaproteobacteria,1XF9Z@135618|Methylococcales	135618|Methylococcales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
k59_833724_1	2340.JV46_26440	1.31e-49	166.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,1RMK2@1236|Gammaproteobacteria,1J4NT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_188285_1	13035.Dacsa_2625	6.69e-28	120.0	COG3210@1|root,COG3595@1|root,COG4070@1|root,COG3210@2|Bacteria,COG3595@2|Bacteria,COG4070@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	ko:K15125,ko:K20276	ko02024,ko05133,map02024,map05133	-	-	-	ko00000,ko00001,ko00536	-	-	-	CHU_C,DUF4097,FG-GAP_2,Glug,Haemagg_act,Laminin_G_3,PA14,SprB
k59_956493_1	58123.JOFJ01000019_gene3864	5.58e-15	79.7	COG1674@1|root,COG1674@2|Bacteria,2GJBR@201174|Actinobacteria,4EFXR@85012|Streptosporangiales	201174|Actinobacteria	D	FtsK/SpoIIIE family	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_SpoIIIE,Yop-YscD_cpl
k59_481305_1	1304865.JAGF01000001_gene2441	3.7e-59	190.0	COG1941@1|root,COG1941@2|Bacteria,2GSPN@201174|Actinobacteria	201174|Actinobacteria	C	NADH ubiquinone oxidoreductase, 20	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
k59_481305_2	1304865.JAGF01000001_gene2440	1.24e-24	99.4	COG0543@1|root,COG0543@2|Bacteria,2HXFY@201174|Actinobacteria	201174|Actinobacteria	CH	Oxidoreductase	asrB	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
k59_422553_1	631362.Thi970DRAFT_04688	2.46e-84	259.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1WWT0@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_897478_1	1156919.QWC_22444	5.74e-70	223.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2VHEP@28216|Betaproteobacteria,3T2TD@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
k59_75725_1	37919.EP51_00880	9.16e-311	860.0	COG1403@1|root,COG3344@1|root,COG1403@2|Bacteria,COG3344@2|Bacteria,2GUJS@201174|Actinobacteria,4FUY0@85025|Nocardiaceae	201174|Actinobacteria	L	Group II intron, maturase-specific domain	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,Intron_maturas2,RVT_1
k59_422556_1	331869.BAL199_28035	3.86e-52	182.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit	MA20_01045	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_773020_1	1121405.dsmv_0449	1.6e-30	120.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WKYE@28221|Deltaproteobacteria,2MHUM@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA-2	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
k59_773020_2	1121405.dsmv_0450	5.83e-51	167.0	COG1014@1|root,COG1014@2|Bacteria,1N2W3@1224|Proteobacteria,42THX@68525|delta/epsilon subdivisions,2WQ6P@28221|Deltaproteobacteria,2MJX2@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	iorB-2	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
k59_833732_1	1123261.AXDW01000006_gene2464	2.36e-170	481.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1X3Z0@135614|Xanthomonadales	135614|Xanthomonadales	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_305134_1	1380354.JIAN01000009_gene3680	2.29e-36	135.0	COG2070@1|root,COG2070@2|Bacteria,2I93H@201174|Actinobacteria	201174|Actinobacteria	S	2-Nitropropane dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
k59_956506_1	717785.HYPMC_0370	6.68e-81	259.0	COG0438@1|root,COG0463@1|root,COG0438@2|Bacteria,COG0463@2|Bacteria,1MUTA@1224|Proteobacteria,2TSPN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	glycosyl transferase group 1	capM	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
k59_540172_1	1041146.ATZB01000016_gene1435	8.24e-77	242.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria,4B93D@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_657927_1	1123237.Salmuc_01166	1.1e-12	68.6	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_833735_1	935567.JAES01000012_gene907	1.56e-38	149.0	COG1629@1|root,COG1629@2|Bacteria,1QU0Y@1224|Proteobacteria,1T1KC@1236|Gammaproteobacteria,1X4MY@135614|Xanthomonadales	135614|Xanthomonadales	P	Outer membrane receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_422564_1	1267005.KB911256_gene1762	2.03e-96	294.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2TRT0@28211|Alphaproteobacteria,3N64U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1482750_1	1049564.TevJSym_ao00570	1.31e-127	375.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1J4U6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	JKL	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0019904,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0090304,GO:0097718,GO:0140098,GO:1901360,GO:1901361,GO:1901575	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C,RhlB
k59_1596094_1	765911.Thivi_4250	4.23e-127	382.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1WWE5@135613|Chromatiales	135613|Chromatiales	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_1125493_1	1504981.KO116_1904	1.96e-90	279.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1S01K@1236|Gammaproteobacteria,1XR9F@135619|Oceanospirillales	135619|Oceanospirillales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_833747_1	1283300.ATXB01000001_gene253	5.56e-43	150.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,1XEN4@135618|Methylococcales	135618|Methylococcales	M	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	dsbC	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
k59_1845508_2	1504672.669786077	1.91e-18	84.7	COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,2VHTR@28216|Betaproteobacteria,4AB3G@80864|Comamonadaceae	28216|Betaproteobacteria	S	Deoxyribodipyrimidine photo-lyase-related protein	-	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP
k59_1367981_1	926569.ANT_13810	2.79e-80	248.0	COG1077@1|root,COG1077@2|Bacteria,2G5KV@200795|Chloroflexi	200795|Chloroflexi	D	TIGRFAM cell shape determining protein, MreB Mrl family	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_1367981_2	1136177.KCA1_0566	2.17e-11	63.5	COG2344@1|root,COG2344@2|Bacteria,1TSMR@1239|Firmicutes,4HB7Q@91061|Bacilli,3F40G@33958|Lactobacillaceae	91061|Bacilli	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
k59_1543864_1	1218084.BBJK01000037_gene3487	2.44e-05	48.9	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VZ6E@28216|Betaproteobacteria,1K0K8@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_1130926_1	367299.JOEE01000008_gene389	1.13e-122	369.0	COG0187@1|root,COG0187@2|Bacteria,2GM1E@201174|Actinobacteria,4FEA1@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA topoisomerase (ATP-hydrolyzing)	gyrB2	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_377905_1	1122239.AULS01000021_gene2484	1.45e-49	181.0	COG2366@1|root,COG2366@2|Bacteria,2GISQ@201174|Actinobacteria,4FK6Q@85023|Microbacteriaceae	201174|Actinobacteria	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_839846_1	546271.Selsp_1910	7.75e-07	53.1	COG0589@1|root,COG0589@2|Bacteria,1U42B@1239|Firmicutes,4H7IH@909932|Negativicutes	909932|Negativicutes	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1845521_1	13689.BV96_04411	2.75e-41	149.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,2K0BK@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_545978_1	572477.Alvin_0490	8.38e-16	76.6	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,1WXR0@135613|Chromatiales	135613|Chromatiales	G	Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides	nagZ	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
k59_545978_2	1234364.AMSF01000082_gene2982	1.28e-13	71.2	COG1580@1|root,COG1580@2|Bacteria,1N2N9@1224|Proteobacteria,1SAF0@1236|Gammaproteobacteria,1XCM6@135614|Xanthomonadales	135614|Xanthomonadales	N	Flagellar basal body-associated protein FliL	-	-	-	-	-	-	-	-	-	-	-	-	FliL
k59_1845522_1	247634.GPB2148_159	1.25e-32	130.0	COG1026@1|root,COG1026@2|Bacteria,1MVDJ@1224|Proteobacteria,1RYNI@1236|Gammaproteobacteria,1J4Y0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Zn-dependent peptidases	-	-	-	ko:K06972	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M16C_assoc,Peptidase_M16,Peptidase_M16_C
k59_778148_1	335543.Sfum_3724	1.24e-100	310.0	COG0077@1|root,COG2876@1|root,COG0077@2|Bacteria,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,42MU4@68525|delta/epsilon subdivisions,2WJ8Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM DAHP synthetase I KDSA	-	-	2.5.1.54,5.4.99.5	ko:K03856,ko:K04516	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022,M00024,M00025	R01715,R01826	RC00435,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,DAHP_synth_1,PDT
k59_965100_1	37682.EMT00244	1.82e-120	355.0	COG0568@1|root,2QVXR@2759|Eukaryota,37Q7Q@33090|Viridiplantae,3G8RP@35493|Streptophyta,3KMSA@4447|Liliopsida,3I7DR@38820|Poales	35493|Streptophyta	K	Sigma factors are initiation factors that promote the attachment of plastid-encoded RNA polymerase (PEP) to specific initiation sites and are then released	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_965100_2	765914.ThisiDRAFT_1457	2.77e-59	197.0	COG4942@1|root,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,1RR11@1236|Gammaproteobacteria,1WW55@135613|Chromatiales	135613|Chromatiales	DM	peptidase	-	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	LysM,Peptidase_M23
k59_965100_3	1283300.ATXB01000001_gene1905	3.22e-07	51.2	COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,1RPT7@1236|Gammaproteobacteria,1XGCA@135618|Methylococcales	135618|Methylococcales	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_1368001_1	765912.Thimo_0429	3.08e-52	179.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,1WWKF@135613|Chromatiales	135613|Chromatiales	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
k59_664073_1	2340.JV46_05560	3.1e-91	279.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1J4WT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	-	-	ko:K10764	ko00270,ko00920,ko01100,map00270,map00920,map01100	-	R01288	RC00020,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1368003_1	292415.Tbd_0077	3.21e-68	224.0	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,2VHSF@28216|Betaproteobacteria,1KS6X@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Cytochrome D1 heme domain	-	-	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_194446_2	870187.Thini_2730	4.66e-25	100.0	arCOG03638@1|root,2Z8W3@2|Bacteria,1N2PH@1224|Proteobacteria,1RMI8@1236|Gammaproteobacteria,461N8@72273|Thiotrichales	72273|Thiotrichales	S	Protein of unknown function (DUF1538)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1538
k59_1490467_1	257310.BB4487	5.74e-79	263.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,3T2UZ@506|Alcaligenaceae	28216|Betaproteobacteria	C	FAD linked oxidase, C-terminal domain-containing protein 6	glpCD	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_1192592_1	631362.Thi970DRAFT_02203	9.7e-33	119.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,1WX5V@135613|Chromatiales	135613|Chromatiales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
k59_1192592_2	246195.DNO_1178	6.95e-46	155.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
k59_1192592_3	765912.Thimo_3609	3.74e-91	274.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,1WX1Y@135613|Chromatiales	135613|Chromatiales	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
k59_1368009_1	1232410.KI421425_gene1552	1.96e-90	296.0	COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
k59_1013122_1	765912.Thimo_2565	4.25e-106	314.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RN9Y@1236|Gammaproteobacteria,1WWGI@135613|Chromatiales	135613|Chromatiales	KO	TIGRFAM Hydrogenase accessory protein HypB	-	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
k59_28544_1	1089551.KE386572_gene2191	8.11e-06	49.3	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,2TTI6@28211|Alphaproteobacteria,4BQ7D@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_28544_2	1123401.JHYQ01000006_gene101	1.71e-63	200.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,46126@72273|Thiotrichales	72273|Thiotrichales	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	-	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
k59_28544_3	62928.azo2585	9.99e-11	63.2	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VIE9@28216|Betaproteobacteria,2KUR5@206389|Rhodocyclales	206389|Rhodocyclales	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,cNMP_binding
k59_604609_1	313628.LNTAR_11841	4.45e-42	152.0	COG1596@1|root,COG1596@2|Bacteria	2|Bacteria	M	polysaccharide export	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
k59_1778449_1	1458357.BG58_09870	1.09e-24	106.0	COG1538@1|root,COG1538@2|Bacteria,1REC6@1224|Proteobacteria,2VZ9S@28216|Betaproteobacteria,1KBKV@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1778449_2	1458357.BG58_09875	1.35e-71	228.0	COG1566@1|root,COG1566@2|Bacteria,1NAMI@1224|Proteobacteria,2VZSW@28216|Betaproteobacteria,1K5Z2@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2
k59_1192594_1	398767.Glov_0875	1.26e-79	249.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2WIYU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Ion transport 2 domain protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
k59_428676_2	156889.Mmc1_0540	9.32e-75	247.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2TWVC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_1543914_1	314264.ROS217_09220	1.21e-86	268.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,46NHC@74030|Roseovarius	28211|Alphaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
k59_1490484_1	1304865.JAGF01000001_gene738	3.99e-34	127.0	COG3677@1|root,COG3677@2|Bacteria,2IF2C@201174|Actinobacteria	201174|Actinobacteria	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_604617_1	395961.Cyan7425_1449	4.65e-102	311.0	COG3119@1|root,COG3119@2|Bacteria,1G3EC@1117|Cyanobacteria,3KGWJ@43988|Cyanothece	1117|Cyanobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_1130970_1	571166.KI421509_gene4150	3.74e-37	142.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TXAW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_906202_2	547559.Nmag_2690	5.4e-17	82.4	COG3247@1|root,arCOG10041@2157|Archaea,2XWIC@28890|Euryarchaeota,23V5B@183963|Halobacteria	183963|Halobacteria	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
k59_262483_1	880072.Desac_0318	7.4e-37	139.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria,2MQAI@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	TIGRFAM phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_262483_2	880072.Desac_0317	1.29e-18	80.5	COG4957@1|root,COG4957@2|Bacteria,1RGUW@1224|Proteobacteria,42VJM@68525|delta/epsilon subdivisions,2WRBG@28221|Deltaproteobacteria,2MSE2@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	PFAM ROSMUCR transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	ROS_MUCR
k59_1778453_1	1049564.TevJSym_bb00290	1.84e-131	403.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1T216@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg
k59_1778453_2	1249627.D779_0034	2.7e-135	391.0	COG3437@1|root,COG3437@2|Bacteria,1QUN9@1224|Proteobacteria,1S0ZZ@1236|Gammaproteobacteria,1WX12@135613|Chromatiales	135613|Chromatiales	KT	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	PAS,PAS_9,Response_reg
k59_135837_1	1454004.AW11_00972	1.26e-14	75.9	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,1KQ8R@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_839888_2	857087.Metme_3494	2.08e-44	150.0	COG1573@1|root,COG1573@2|Bacteria,1QJIF@1224|Proteobacteria,1THIQ@1236|Gammaproteobacteria,1XEAT@135618|Methylococcales	135618|Methylococcales	L	uracil-DNA	-	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_28583_2	1713.JOFV01000003_gene1614	1.79e-07	55.5	COG2372@1|root,COG2372@2|Bacteria,2HYZZ@201174|Actinobacteria,4F1HZ@85016|Cellulomonadaceae	201174|Actinobacteria	S	CopC domain	-	-	-	-	-	-	-	-	-	-	-	-	CopC
k59_1255750_1	1384054.N790_05560	9.9e-73	241.0	COG4773@1|root,COG4773@2|Bacteria,1MWUQ@1224|Proteobacteria,1SJYF@1236|Gammaproteobacteria,1X5UY@135614|Xanthomonadales	135614|Xanthomonadales	P	Outer membrane receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_1255750_2	1384054.N790_05555	9.51e-60	201.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria,1X3GK@135614|Xanthomonadales	135614|Xanthomonadales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_16,TPR_19,TPR_8
k59_906217_1	887898.HMPREF0551_0421	4.1e-35	132.0	COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,2WGXN@28216|Betaproteobacteria,1KINJ@119060|Burkholderiaceae	28216|Betaproteobacteria	O	OsmC-like protein	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Hydrolase_4,OsmC
k59_428700_1	1167006.UWK_00715	2.92e-119	361.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42NQG@68525|delta/epsilon subdivisions,2WJXC@28221|Deltaproteobacteria,2MJBJ@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM DNA topoisomerase III, bacteria and conjugative plasmid	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	DEAD,HRDC,Helicase_C,RecQ_Zn_bind,Topoisom_bac,Toprim,Toprim_Crpt,zf-C4_Topoisom
k59_194482_2	1123518.ARWI01000001_gene826	5.96e-20	89.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,45ZWD@72273|Thiotrichales	72273|Thiotrichales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_1719945_1	713586.KB900536_gene2363	9.72e-91	283.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WX5F@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_1719945_2	1049564.TevJSym_av00360	3.15e-47	171.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1J4UY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	general secretion pathway protein D	xcsD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_1845594_1	765913.ThidrDRAFT_3167	4.42e-203	574.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1WVXY@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_1845594_2	1123054.KB907703_gene1234	8.52e-87	276.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1WXD7@135613|Chromatiales	135613|Chromatiales	M	lytic transglycosylase	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_965181_1	582899.Hden_1265	4.89e-15	74.7	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2TR4T@28211|Alphaproteobacteria,3N63J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_965181_2	526227.Mesil_0962	1.95e-07	55.8	COG0517@1|root,COG0517@2|Bacteria,1WJ0F@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	CBS domain	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
k59_428723_1	1123267.JONN01000001_gene1238	3.14e-49	180.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,MRJP
k59_722581_1	572477.Alvin_0985	2.61e-43	157.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1WW51@135613|Chromatiales	135613|Chromatiales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_839925_1	590998.Celf_1632	2.32e-96	292.0	COG0079@1|root,COG0079@2|Bacteria,2GJ9W@201174|Actinobacteria,4F0SI@85016|Cellulomonadaceae	201174|Actinobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1543989_1	1397527.Q670_14645	3.62e-34	131.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XI69@135619|Oceanospirillales	135619|Oceanospirillales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1845604_1	261292.Nit79A3_2992	1.56e-42	149.0	2CNMZ@1|root,32SHD@2|Bacteria,1PYEV@1224|Proteobacteria,2WDN4@28216|Betaproteobacteria,37460@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1778502_1	196162.Noca_2487	5.84e-34	132.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,KAP_NTPase,PAS_4,Response_reg,TIR_2,Trans_reg_C
k59_1256846_1	1121405.dsmv_0971	8.55e-34	128.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2MHS6@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1256846_2	589865.DaAHT2_2005	4.64e-26	104.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,42M46@68525|delta/epsilon subdivisions,2WJ7G@28221|Deltaproteobacteria,2MIHH@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.5.2	ko:K00254,ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01868,R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_488250_1	270374.MELB17_22545	2.26e-55	189.0	COG3677@1|root,COG3677@2|Bacteria,1NUTK@1224|Proteobacteria,1S11R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_1491431_1	1328313.DS2_05110	1.02e-33	125.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,465Y3@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0739 Membrane proteins related to metalloendopeptidases	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_195245_1	880072.Desac_1317	8.24e-69	224.0	COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,42M2C@68525|delta/epsilon subdivisions,2WIVE@28221|Deltaproteobacteria,2MQT5@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
k59_1131844_1	1463856.JOHY01000034_gene2360	9.34e-41	153.0	COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria	201174|Actinobacteria	O	Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
k59_907269_1	1123284.KB899043_gene138	2.1e-48	171.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,4HAM2@91061|Bacilli,26NKT@186821|Sporolactobacillaceae	91061|Bacilli	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA-synt_His
k59_1663335_2	2340.JV46_24710	2.32e-47	157.0	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,1S4ZT@1236|Gammaproteobacteria,1JBSY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulfur oxidation protein SoxY	soxY	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY,SoxZ,TAT_signal
k59_488256_1	1226322.HMPREF1545_01399	1.25e-34	127.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,2N887@216572|Oscillospiraceae	186801|Clostridia	C	Electron transfer flavoprotein domain	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
k59_1318448_1	1382359.JIAL01000001_gene774	1.03e-62	206.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,3Y2FA@57723|Acidobacteria,2JI4J@204432|Acidobacteriia	204432|Acidobacteriia	C	Catalyzes the reversible hydration of fumarate to (S)- malate	-	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
k59_1131848_1	472759.Nhal_3602	2.47e-101	304.0	COG1180@1|root,COG1180@2|Bacteria,1R8XY@1224|Proteobacteria,1T0C7@1236|Gammaproteobacteria,1X2MB@135613|Chromatiales	135613|Chromatiales	O	Radical SAM superfamily	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_1779309_2	1286106.MPL1_05734	2.61e-70	218.0	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,1S5B7@1236|Gammaproteobacteria,463KN@72273|Thiotrichales	72273|Thiotrichales	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_1602932_1	765912.Thimo_0385	4.6e-06	47.8	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1TAE6@1236|Gammaproteobacteria,1WYSH@135613|Chromatiales	135613|Chromatiales	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_1193401_1	523791.Kkor_0267	7.1e-47	152.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,1XKHD@135619|Oceanospirillales	135619|Oceanospirillales	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
k59_263780_1	240016.ABIZ01000001_gene3549	4.26e-46	161.0	COG0577@1|root,COG0577@2|Bacteria,46UQN@74201|Verrucomicrobia,2IVBP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1846629_1	768671.ThimaDRAFT_4701	1.88e-94	299.0	COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria,1WX8D@135613|Chromatiales	135613|Chromatiales	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_1082713_1	768704.Desmer_4047	1.24e-25	109.0	COG5598@1|root,COG5598@2|Bacteria,1UYBQ@1239|Firmicutes,249D7@186801|Clostridia,260FT@186807|Peptococcaceae	186801|Clostridia	H	PFAM Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
k59_546838_1	1121405.dsmv_3755	2.99e-57	181.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,42RHA@68525|delta/epsilon subdivisions,2WNQW@28221|Deltaproteobacteria,2MJW2@213118|Desulfobacterales	28221|Deltaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
k59_895903_1	690850.Desaf_1999	5.25e-39	148.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2M7S1@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_954886_1	1041146.ATZB01000037_gene104	5.56e-50	176.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,4B9W8@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	MA20_17495	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_954886_2	247633.GP2143_12726	1.02e-81	244.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,1S3RP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase small subunit CoxS	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_1070485_1	1123269.NX02_20110	1.77e-83	262.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2K2UN@204457|Sphingomonadales	204457|Sphingomonadales	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1307036_1	1283300.ATXB01000001_gene1705	8.45e-47	165.0	COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,1SZW9@1236|Gammaproteobacteria,1XFPE@135618|Methylococcales	135618|Methylococcales	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
k59_421359_1	1123256.KB907927_gene1701	1.48e-44	162.0	COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,1RXT9@1236|Gammaproteobacteria,1X4PW@135614|Xanthomonadales	135614|Xanthomonadales	L	DNA polymerase beta thumb	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8,PHP
k59_1835289_1	591158.SSMG_06890	3.54e-11	67.0	COG0531@1|root,COG0531@2|Bacteria,2GJ75@201174|Actinobacteria	201174|Actinobacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_74175_1	351016.RAZWK3B_01255	5.61e-78	243.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,2P10V@2433|Roseobacter	28211|Alphaproteobacteria	E	COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_656761_1	1122604.JONR01000009_gene2465	3.35e-57	194.0	COG1538@1|root,COG1538@2|Bacteria,1N23P@1224|Proteobacteria,1RMXN@1236|Gammaproteobacteria,1X8EQ@135614|Xanthomonadales	135614|Xanthomonadales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_656761_2	314254.OA2633_11605	6.73e-06	48.1	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2V9IG@28211|Alphaproteobacteria,43Z5S@69657|Hyphomonadaceae	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1712592_2	1408422.JHYF01000003_gene918	2.13e-32	121.0	COG3404@1|root,COG3404@2|Bacteria,1V1X8@1239|Firmicutes,24JZM@186801|Clostridia,36JRA@31979|Clostridiaceae	186801|Clostridia	E	cyclohydrolase	fchA	-	-	-	-	-	-	-	-	-	-	-	FTCD_C
k59_832592_1	402881.Plav_1535	6.6e-93	304.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1360508_2	1215092.PA6_046_00230	5.17e-47	171.0	COG3497@1|root,COG3497@2|Bacteria,1MX89@1224|Proteobacteria,1RQUU@1236|Gammaproteobacteria,1YH70@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
k59_1070508_1	1396141.BATP01000021_gene152	4.3e-71	228.0	COG0657@1|root,COG0657@2|Bacteria,46URC@74201|Verrucomicrobia,2IVMY@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
k59_1124504_1	322710.Avin_14570	8.18e-86	286.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1124504_2	1122194.AUHU01000002_gene2632	4.73e-16	73.2	2ENKU@1|root,33G87@2|Bacteria,1NMH6@1224|Proteobacteria,1SGDI@1236|Gammaproteobacteria,468YW@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_480202_2	938293.CAJU020000016_gene1814	3.45e-27	106.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,22FXF@1570339|Peptoniphilaceae	186801|Clostridia	V	ABC transporter, ATP-binding protein	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_895944_1	1163407.UU7_04862	2.09e-63	213.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1X9T5@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1771070_1	1121396.KB893063_gene1210	1.44e-86	283.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MI2Z@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Hydrophobe Amphiphile Efflux-1 (HAE1) Family	bepE	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1070518_1	471853.Bcav_3816	3.46e-177	506.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria	201174|Actinobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	mrpD	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_1536492_1	1048339.KB913029_gene958	4.76e-49	171.0	COG4638@1|root,COG4638@2|Bacteria,2GMB2@201174|Actinobacteria,4EX84@85013|Frankiales	201174|Actinobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
k59_367707_1	1049564.TevJSym_bb00050	2.42e-132	395.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_1307085_1	396588.Tgr7_1453	1.42e-59	186.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,1WYQC@135613|Chromatiales	135613|Chromatiales	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
k59_1307085_2	357804.Ping_2217	1.67e-25	96.7	COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,2QIDF@267894|Psychromonadaceae	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
k59_304068_1	886293.Sinac_5969	1.18e-14	72.8	COG0152@1|root,COG0152@2|Bacteria,2IY7D@203682|Planctomycetes	203682|Planctomycetes	F	SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
k59_480211_1	187272.Mlg_0956	1.11e-119	369.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WXNN@135613|Chromatiales	135613|Chromatiales	F	PFAM glycosyl transferase family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_1482195_1	1304865.JAGF01000001_gene1912	6.08e-47	173.0	COG4995@1|root,COG4995@2|Bacteria,2GKCX@201174|Actinobacteria,4F212@85016|Cellulomonadaceae	201174|Actinobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12
k59_955968_1	926550.CLDAP_36730	5.03e-125	370.0	COG1960@1|root,COG1960@2|Bacteria,2G5J5@200795|Chloroflexi	200795|Chloroflexi	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1071666_1	457425.XNR_1697	2.59e-35	131.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	dppD	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_1071666_2	1429916.X566_16215	4.1e-07	52.4	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,3JRIW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_368739_1	525897.Dbac_2683	6.24e-41	140.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WRBN@28221|Deltaproteobacteria,2MBT4@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_1186036_1	378806.STAUR_1021	1.07e-11	70.9	COG0515@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BX5@68525|delta/epsilon subdivisions,2X77Z@28221|Deltaproteobacteria,2YY1C@29|Myxococcales	28221|Deltaproteobacteria	KLT	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,HATPase_c,Pkinase
k59_75230_1	754477.Q7C_2507	7.63e-80	263.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,45ZMV@72273|Thiotrichales	72273|Thiotrichales	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_2,OstA_C
k59_75230_2	666681.M301_0594	2.8e-118	360.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,2KKDR@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
k59_1361311_1	765914.ThisiDRAFT_1088	1.4e-18	86.3	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1WXD9@135613|Chromatiales	135613|Chromatiales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_1361311_2	1049564.TevJSym_ba00120	7.3e-57	192.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1J565@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	zinc metalloprotease	rseP	GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_304789_1	743720.Psefu_2086	2.24e-18	87.8	COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,1RNJ3@1236|Gammaproteobacteria,1YVVT@136845|Pseudomonas putida group	1236|Gammaproteobacteria	M	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_598121_1	1313172.YM304_38340	4.35e-94	287.0	COG0174@1|root,COG0174@2|Bacteria,2GJ2I@201174|Actinobacteria,4CMV7@84992|Acidimicrobiia	84992|Acidimicrobiia	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_955997_1	517418.Ctha_0772	1.79e-54	176.0	COG2839@1|root,COG2839@2|Bacteria,1FE53@1090|Chlorobi	1090|Chlorobi	S	Protein of unknown function (DUF456)	-	-	-	ko:K09793	-	-	-	-	ko00000	-	-	-	DUF456
k59_833390_1	187272.Mlg_2419	2.04e-24	98.6	COG3065@1|root,COG3065@2|Bacteria,1MZ8C@1224|Proteobacteria,1S9UB@1236|Gammaproteobacteria,1WYUD@135613|Chromatiales	135613|Chromatiales	M	PFAM Outer membrane lipoprotein Slp	-	-	-	ko:K07285	-	-	-	-	ko00000	-	-	-	Slp
k59_304794_1	1158292.JPOE01000005_gene1144	3.28e-65	210.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,1KKHM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_1007677_1	335283.Neut_1665	1.21e-105	341.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2VKDG@28216|Betaproteobacteria,371PE@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
k59_1771808_2	313624.NSP_26100	0.000114	45.4	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,1GC0N@1117|Cyanobacteria,1HR0M@1161|Nostocales	1117|Cyanobacteria	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
k59_1655814_1	452863.Achl_2083	8.87e-51	178.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,1WATE@1268|Micrococcaceae	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
k59_1713347_1	1038858.AXBA01000023_gene423	3.53e-13	68.2	arCOG09452@1|root,335JP@2|Bacteria,1RJGH@1224|Proteobacteria,2UG21@28211|Alphaproteobacteria,3EZR3@335928|Xanthobacteraceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1247191_1	292415.Tbd_0071	1.53e-147	425.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VJD9@28216|Betaproteobacteria,1KSZD@119069|Hydrogenophilales	119069|Hydrogenophilales	C	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
k59_480951_1	1379270.AUXF01000001_gene2189	1.08e-99	308.0	COG0365@1|root,COG0365@2|Bacteria,1ZU93@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Acetyl-coenzyme A synthetase N-terminus	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1836383_2	1131814.JAFO01000001_gene2457	9.53e-11	60.8	COG3791@1|root,COG3791@2|Bacteria,1N6S5@1224|Proteobacteria,2VAN5@28211|Alphaproteobacteria,3F06I@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating GFA	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_253287_1	1173026.Glo7428_0430	4.01e-60	211.0	COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria	1117|Cyanobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF,PAS_3,PAS_9
k59_833405_1	1122933.JNIY01000004_gene2532	1.34e-51	174.0	COG0083@1|root,COG0083@2|Bacteria,2GKIW@201174|Actinobacteria,4F0RU@85016|Cellulomonadaceae	201174|Actinobacteria	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_1482251_1	335659.S23_53050	5.76e-97	294.0	COG1804@1|root,COG1804@2|Bacteria,1MVK4@1224|Proteobacteria,2TWRE@28211|Alphaproteobacteria,3JSRH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	MA20_17775	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_1482251_2	537970.HCAN_0077	7.81e-10	59.3	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,42R6H@68525|delta/epsilon subdivisions,2YP0H@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_1713358_1	765914.ThisiDRAFT_0951	3.7e-156	477.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_368793_1	1219031.BBJR01000063_gene1252	9.86e-36	131.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2VHEC@28216|Betaproteobacteria,4AA7A@80864|Comamonadaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_368793_2	3067.XP_002947050.1	7.44e-27	108.0	COG1905@1|root,KOG3196@2759|Eukaryota,37PIM@33090|Viridiplantae,34H6I@3041|Chlorophyta	3041|Chlorophyta	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3,1.6.99.3	ko:K03943	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1.6	-	-	2Fe-2S_thioredx
k59_897033_1	243233.MCA1845	1.01e-120	372.0	COG4457@1|root,COG4457@2|Bacteria,1MVRQ@1224|Proteobacteria,1RPSQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Virulence	srfB	-	-	-	-	-	-	-	-	-	-	-	SrfB
k59_1071733_1	316067.Geob_3147	1.1e-31	128.0	COG0236@1|root,COG1028@1|root,COG3321@1|root,COG0236@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,42NGA@68525|delta/epsilon subdivisions,2WJK3@28221|Deltaproteobacteria,43W01@69541|Desulfuromonadales	28221|Deltaproteobacteria	IQ	PFAM Beta-ketoacyl synthase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,FabA,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
k59_253302_2	713587.THITH_15740	1.1e-36	131.0	COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,1RMUT@1236|Gammaproteobacteria,1WX1H@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
k59_1421030_1	1049564.TevJSym_at00170	8.34e-64	214.0	COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,1RT8G@1236|Gammaproteobacteria,1JA1H@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	HDOD domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	HDOD
k59_304815_1	472759.Nhal_2288	8.49e-73	235.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria,1WWCF@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3329,HATPase_c,HisKA,PAS,PAS_8
k59_129262_1	224911.27349090	2.51e-30	114.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U6Z6@28211|Alphaproteobacteria,3JR0E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	1.3.99.16	ko:K00256,ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
k59_129262_2	1121861.KB899924_gene3479	2.19e-15	77.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,2JPB3@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_897039_1	1298867.AUES01000051_gene4507	3.64e-67	222.0	COG0845@1|root,COG0845@2|Bacteria,1N97Q@1224|Proteobacteria,2U22Z@28211|Alphaproteobacteria,3K3DU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,GAF,HlyD_3,HlyD_D23
k59_253310_1	177437.HRM2_05410	4.57e-77	241.0	COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,42NSB@68525|delta/epsilon subdivisions,2WIKP@28221|Deltaproteobacteria,2MJ70@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K09970	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
k59_657575_1	1049564.TevJSym_ah00300	1.26e-17	79.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1J5Q9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0006950,GO:0006970,GO:0008150,GO:0009266,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1308200_1	1125718.HMPREF1318_2369	4.94e-39	151.0	COG1484@1|root,COG1484@2|Bacteria,2GKSE@201174|Actinobacteria	201174|Actinobacteria	L	DNA-dependent DNA replication	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_716213_1	1249627.D779_4148	8.06e-110	339.0	COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,1WW3V@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA	rlmL	-	2.1.1.173,2.1.1.264	ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
k59_19708_1	153948.NAL212_2002	5.53e-21	88.2	COG2009@1|root,COG2009@2|Bacteria,1RIGZ@1224|Proteobacteria,2VSEG@28216|Betaproteobacteria,373AZ@32003|Nitrosomonadales	28216|Betaproteobacteria	C	succinate dehydrogenase, cytochrome b subunit	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_19708_2	265072.Mfla_1904	1.29e-15	77.8	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2VK2D@28216|Betaproteobacteria,2KKIN@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
k59_1071762_2	525898.Sdel_2106	3.04e-14	69.3	2E65Y@1|root,330UM@2|Bacteria,1N8U3@1224|Proteobacteria,42VZJ@68525|delta/epsilon subdivisions,2YSEQ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_897049_2	1354303.M917_1158	4.92e-05	49.7	COG3339@1|root,COG3339@2|Bacteria,1N9BI@1224|Proteobacteria,1SC8Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
k59_897049_3	1122197.ATWI01000014_gene44	1e-19	85.5	COG1192@1|root,COG1192@2|Bacteria,1MVEZ@1224|Proteobacteria,1RPWA@1236|Gammaproteobacteria,465CH@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	COG1192 ATPases involved in chromosome partitioning	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_1247240_1	1121405.dsmv_0122	2.42e-101	305.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,42MSF@68525|delta/epsilon subdivisions,2WKJ5@28221|Deltaproteobacteria,2MI15@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1099	AlaDh_PNT_C,AlaDh_PNT_N
k59_187967_1	136993.KB900626_gene2932	1.23e-76	239.0	COG3252@1|root,COG3252@2|Bacteria,1MUP6@1224|Proteobacteria,2U0JJ@28211|Alphaproteobacteria,36Z66@31993|Methylocystaceae	28211|Alphaproteobacteria	H	Cyclohydrolase (MCH)	mch	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
k59_187967_2	1267005.KB911258_gene247	1.74e-107	321.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,2TRUH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	HJ	Belongs to the RimK family	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
k59_598164_1	314285.KT71_06252	1.04e-22	97.8	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S876@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_480982_1	1429916.X566_21135	4.08e-68	218.0	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,2TRUD@28211|Alphaproteobacteria,3JT5T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Predicted integral membrane protein (DUF2189)	MA20_41380	-	-	-	-	-	-	-	-	-	-	-	DUF2189
k59_833430_1	744980.TRICHSKD4_2450	2.1e-41	142.0	2CCMQ@1|root,32RW3@2|Bacteria,1MZHB@1224|Proteobacteria,2UCC9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2794)	MA20_43795	-	-	-	-	-	-	-	-	-	-	-	DUF2794
k59_1071764_1	986075.CathTA2_1988	3.83e-11	65.1	COG0517@1|root,COG0517@2|Bacteria,1V0XU@1239|Firmicutes,4HD12@91061|Bacilli	91061|Bacilli	S	acetoin utilization protein	acuB	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
k59_1713384_1	1337093.MBE-LCI_2013	7.77e-264	736.0	COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,2TTW4@28211|Alphaproteobacteria,2P9FK@245186|Loktanella	28211|Alphaproteobacteria	T	PrkA AAA domain	yeaG	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
k59_1600038_1	446469.Sked_20910	2.56e-168	477.0	COG2519@1|root,COG2519@2|Bacteria,2GJPD@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	trmI	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
k59_1842410_1	1163617.SCD_n00391	1.04e-81	247.0	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2VH27@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A,Sugar-bind
k59_602347_1	367299.JOEE01000003_gene2706	1.28e-118	365.0	COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4FF6A@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1365790_1	1267005.KB911257_gene687	6.66e-85	268.0	COG4547@1|root,COG4547@2|Bacteria,1MX11@1224|Proteobacteria,2TS4N@28211|Alphaproteobacteria,3N691@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	cobalt chelatase	cobT	-	6.6.1.2	ko:K09883	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	CobT,CobT_C
k59_192287_1	1306174.JODP01000001_gene4675	5.06e-44	162.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GM2E@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD2	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1078608_1	1122212.AULO01000012_gene1021	1.45e-34	136.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1XI7H@135619|Oceanospirillales	135619|Oceanospirillales	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	mltF	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
k59_426421_1	1123229.AUBC01000026_gene4087	1.37e-18	85.1	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2TU5C@28211|Alphaproteobacteria,3JR92@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Probable molybdopterin binding domain	cinA1	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
k59_776219_1	411476.BACOVA_03345	4.65e-54	191.0	COG3250@1|root,COG3250@2|Bacteria,4NH5T@976|Bacteroidetes,2FMQ4@200643|Bacteroidia,4APW5@815|Bacteroidaceae	976|Bacteroidetes	G	COG NOG09951 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	DUF1793,DUF4964,DUF4965,DUF5127
k59_962066_1	1304865.JAGF01000001_gene2951	2.64e-97	298.0	COG0327@1|root,COG0327@2|Bacteria,2GKHZ@201174|Actinobacteria,4F0E5@85016|Cellulomonadaceae	201174|Actinobacteria	S	Belongs to the GTP cyclohydrolase I type 2 NIF3 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	NIF3
k59_1425327_1	1089552.KI911559_gene2411	0.000965	41.6	COG3090@1|root,COG3090@2|Bacteria,1MVKS@1224|Proteobacteria,2U08K@28211|Alphaproteobacteria,2JSXA@204441|Rhodospirillales	204441|Rhodospirillales	G	COG3090 TRAP-type C4-dicarboxylate transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_1425327_2	1238182.C882_0338	4.14e-19	85.9	COG1638@1|root,COG1638@2|Bacteria,1MWAW@1224|Proteobacteria,2TV91@28211|Alphaproteobacteria,2JRN7@204441|Rhodospirillales	204441|Rhodospirillales	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1776133_1	84531.JMTZ01000006_gene3514	1.87e-46	169.0	COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1X4R3@135614|Xanthomonadales	135614|Xanthomonadales	E	homoserine dehydrogenase	thrA	-	1.1.1.3,2.7.2.4	ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3
k59_1660204_1	686340.Metal_1126	4.56e-42	149.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1XDTI@135618|Methylococcales	135618|Methylococcales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1660204_2	426114.THI_2700	5.82e-42	146.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2VPZV@28216|Betaproteobacteria,1KK51@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
k59_1842424_1	95619.PM1_0202845	4.62e-101	298.0	COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	GO:0000287,GO:0003674,GO:0003824,GO:0004588,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_2819,iECIAI39_1322.ECIAI39_4161,iEcSMS35_1347.EcSMS35_3977,iUTI89_1310.UTI89_C4186	Pribosyltran
k59_1842424_2	288000.BBta_7340	9.17e-31	120.0	COG2211@1|root,COG2211@2|Bacteria,1QTSE@1224|Proteobacteria,2TWGV@28211|Alphaproteobacteria,3JS00@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Acetyl-coenzyme A transporter 1	ampG	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	Acatn,MFS_1
k59_25043_1	744979.R2A130_0099	4.17e-30	119.0	COG3713@1|root,COG3713@2|Bacteria,1N0BC@1224|Proteobacteria,2U7QE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	MltA-interacting MipA family protein	-	-	-	-	-	-	-	-	-	-	-	-	MipA
k59_1252742_1	1049564.TevJSym_bo00190	1.14e-81	270.0	COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,1RQ9A@1236|Gammaproteobacteria,1J616@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	ko:K02569	-	-	-	-	ko00000	-	-	-	Cytochrom_NNT,EB_dh
k59_1128992_1	1260251.SPISAL_02640	1.31e-30	118.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1WWGT@135613|Chromatiales	135613|Chromatiales	S	Permease YjgP YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_1128992_2	523791.Kkor_1822	1.19e-21	94.7	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,1XH34@135619|Oceanospirillales	135619|Oceanospirillales	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_903092_1	765911.Thivi_2864	1.33e-85	263.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1WX4M@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_903092_2	1131269.AQVV01000014_gene175	0.000222	43.9	COG1883@1|root,COG1883@2|Bacteria	2|Bacteria	C	oxaloacetate decarboxylase activity	gcdB	-	4.1.1.3,4.1.1.70	ko:K01572,ko:K01615	ko00362,ko00620,ko00650,ko01100,ko01120,map00362,map00620,map00650,map01100,map01120	-	R00217,R03028	RC00040,RC00832	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1,3.B.1.1.3	-	-	OAD_beta
k59_962072_1	1283300.ATXB01000001_gene2011	9.26e-45	154.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,1XE5I@135618|Methylococcales	135618|Methylococcales	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_962072_2	396588.Tgr7_2914	6.97e-58	194.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1WVVC@135613|Chromatiales	135613|Chromatiales	F	TIGRFAM dihydroorotase, multifunctional complex type	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_1717668_1	472759.Nhal_0542	2.76e-31	114.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,1WYQV@135613|Chromatiales	135613|Chromatiales	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
k59_81284_1	754477.Q7C_2190	1.21e-07	52.4	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,45ZZM@72273|Thiotrichales	72273|Thiotrichales	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
k59_81284_2	519989.ECTPHS_03884	2.67e-108	326.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1WX7A@135613|Chromatiales	135613|Chromatiales	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_903094_1	313624.NSP_41490	1.4e-30	122.0	COG0526@1|root,COG3391@1|root,COG0526@2|Bacteria,COG3391@2|Bacteria,1G3NB@1117|Cyanobacteria,1HMXB@1161|Nostocales	1117|Cyanobacteria	O	PFAM AhpC TSA family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,NHL,Thioredoxin_8
k59_1011151_1	1163617.SCD_n01883	2.06e-158	469.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,2WEVG@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	ko:K16886	-	-	-	-	ko00000	-	-	-	Fer4,FlpD,Pyr_redox_2
k59_1011151_2	1123401.JHYQ01000007_gene512	2.06e-123	363.0	COG1148@1|root,COG1148@2|Bacteria,1Q0ZF@1224|Proteobacteria,1RYIC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	FAD dependent oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388,ko:K16885	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Pyr_redox_2
k59_81292_1	857087.Metme_2063	1.38e-71	237.0	COG3291@1|root,COG3291@2|Bacteria,1R5MQ@1224|Proteobacteria,1TI1G@1236|Gammaproteobacteria,1XGA7@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c5530 family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1660224_1	743718.Isova_2078	3.22e-42	157.0	COG4987@1|root,COG4987@2|Bacteria,2H79B@201174|Actinobacteria,4F41C@85017|Promicromonosporaceae	201174|Actinobacteria	V	TIGRFAM ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC	cydC	-	-	ko:K06148,ko:K16012	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.129	-	-	ABC_membrane,ABC_tran
k59_1365825_1	1047013.AQSP01000122_gene2249	3.34e-81	259.0	28NDD@1|root,2ZBG6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1011162_1	1121921.KB898709_gene119	4.67e-11	63.5	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RP0T@1236|Gammaproteobacteria,2PPZV@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	I	Phospholipase D Active site motif	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2,PLDc_N
k59_1011162_2	761193.Runsl_2123	8.35e-17	82.4	COG5002@1|root,COG5002@2|Bacteria,4PP2P@976|Bacteroidetes,47YFN@768503|Cytophagia	976|Bacteroidetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_903113_2	768671.ThimaDRAFT_0576	1e-33	116.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1WZ1Y@135613|Chromatiales	135613|Chromatiales	K	PFAM Cold-shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_1717687_1	1121923.GPUN_0121	3.5e-54	178.0	COG3751@1|root,COG3751@2|Bacteria,1RD3H@1224|Proteobacteria,1S40I@1236|Gammaproteobacteria,46712@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	2OG-Fe(II) oxygenase	-	-	-	ko:K07394	-	-	-	-	ko00000	-	-	-	2OG-FeII_Oxy_3
k59_1129017_1	56110.Oscil6304_0344	3.5e-64	204.0	COG0395@1|root,COG0395@2|Bacteria,1G0JV@1117|Cyanobacteria,1H7WS@1150|Oscillatoriales	2|Bacteria	G	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_720590_1	314278.NB231_10979	5.24e-25	101.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,1WY32@135613|Chromatiales	135613|Chromatiales	P	SMART Rhodanese domain protein	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_903126_1	365528.KB891266_gene5954	9.74e-18	87.4	COG0455@1|root,COG0455@2|Bacteria,2IARP@201174|Actinobacteria,4ERDT@85013|Frankiales	201174|Actinobacteria	D	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
k59_1660239_1	1121918.ARWE01000001_gene383	2.75e-100	304.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,42MVJ@68525|delta/epsilon subdivisions,2WKM4@28221|Deltaproteobacteria,43T3E@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Aldehyde dehydrogenase family	mmsA	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_192338_1	156889.Mmc1_1170	3.74e-132	384.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VFW2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	TIGRFAM poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
k59_1314306_1	1121015.N789_11155	2.57e-05	46.2	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,1X3AV@135614|Xanthomonadales	135614|Xanthomonadales	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_1314306_2	1095769.CAHF01000011_gene2273	1.84e-18	84.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2VH6I@28216|Betaproteobacteria,472J2@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
k59_661996_2	367299.JOEE01000001_gene2092	3.91e-71	229.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4FE77@85021|Intrasporangiaceae	201174|Actinobacteria	C	NADH dehydrogenase	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1487787_1	713586.KB900536_gene1024	2.47e-05	44.3	COG0316@1|root,COG0316@2|Bacteria,1RKPC@1224|Proteobacteria,1SB76@1236|Gammaproteobacteria,1WYKT@135613|Chromatiales	135613|Chromatiales	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
k59_1487787_2	1163617.SCD_n02704	1.43e-50	174.0	COG1249@1|root,COG1249@2|Bacteria,1RB5F@1224|Proteobacteria	1224|Proteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	lpdA_2	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1842475_1	381666.H16_A1028	1.76e-59	196.0	COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2VJ5X@28216|Betaproteobacteria,1K1CS@119060|Burkholderiaceae	28216|Betaproteobacteria	M	glycosyl transferase group 1	gtrA	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
k59_374898_1	314278.NB231_14036	3.08e-29	108.0	2AGHX@1|root,316QI@2|Bacteria,1RI7I@1224|Proteobacteria,1S8W9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_374898_2	1128421.JAGA01000002_gene1399	1.49e-128	382.0	COG1032@1|root,COG1032@2|Bacteria,2NQJQ@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_776260_1	314254.OA2633_00725	2.48e-88	275.0	COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2TRN0@28211|Alphaproteobacteria,43X30@69657|Hyphomonadaceae	28211|Alphaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_1078688_1	765912.Thimo_2734	7.52e-47	162.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,1RS3E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_25095_1	381666.H16_B1201	4.05e-44	160.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,2VMB7@28216|Betaproteobacteria,1KBYR@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Major Facilitator Superfamily	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	MFS_1,TLC
k59_81341_1	859657.RPSI07_1464	4.13e-37	130.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2VSVW@28216|Betaproteobacteria,1K70R@119060|Burkholderiaceae	28216|Betaproteobacteria	U	PFAM Biopolymer transport protein ExbD TolR	exbD1	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_903143_1	1122603.ATVI01000011_gene2081	8.47e-159	458.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1RMVU@1236|Gammaproteobacteria,1X68C@135614|Xanthomonadales	135614|Xanthomonadales	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
k59_903143_2	290397.Adeh_2305	2.07e-15	75.9	COG5322@1|root,COG5322@2|Bacteria,1R60X@1224|Proteobacteria,42Q8F@68525|delta/epsilon subdivisions,2WK4X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_258870_1	1121861.KB899930_gene178	2.43e-61	207.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,2JQAX@204441|Rhodospirillales	204441|Rhodospirillales	V	ABC-type multidrug transport system, ATPase and permease	msbA	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1078699_1	1523503.JPMY01000001_gene3707	3.26e-10	65.9	COG2271@1|root,COG2271@2|Bacteria,1R9N6@1224|Proteobacteria,1S08F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1314323_1	472759.Nhal_3273	4.7e-46	159.0	COG3103@1|root,COG4991@2|Bacteria,1MX7M@1224|Proteobacteria,1RS74@1236|Gammaproteobacteria,1WY3A@135613|Chromatiales	135613|Chromatiales	T	SH3 domain	-	-	-	ko:K07184	-	-	-	-	ko00000	-	-	-	SH3_3
k59_602417_1	1005048.CFU_1065	2.9e-37	130.0	COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria,2VU39@28216|Betaproteobacteria,474U5@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
k59_25114_1	1229203.KI301992_gene2133	3.81e-17	79.0	COG0250@1|root,COG0250@2|Bacteria,2GJFW@201174|Actinobacteria,3UWJ1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusG
k59_25114_2	548476.cauri_0354	6.63e-55	174.0	COG0080@1|root,COG0080@2|Bacteria,2IFCK@201174|Actinobacteria,22MWG@1653|Corynebacteriaceae	201174|Actinobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_662014_1	545264.KB898750_gene314	2.61e-56	186.0	COG4261@1|root,COG4261@2|Bacteria,1MVXJ@1224|Proteobacteria,1RNKV@1236|Gammaproteobacteria,1WW87@135613|Chromatiales	135613|Chromatiales	S	Bacterial lipid A biosynthesis acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Lip_A_acyltrans
k59_1541789_2	1043205.AFYF01000029_gene243	2.97e-73	232.0	COG4149@1|root,COG4149@2|Bacteria,2GJFB@201174|Actinobacteria,4FF2T@85021|Intrasporangiaceae	201174|Actinobacteria	P	Molybdate ABC transporter permease	modB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,BPD_transp_1,TOBE
k59_1078723_1	582899.Hden_0708	1.89e-31	119.0	COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria,3N8G4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
k59_1078723_2	1521187.JPIM01000127_gene250	8.16e-16	72.8	COG3293@1|root,COG3293@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_1717735_2	28444.JODQ01000002_gene4082	1.9e-126	383.0	COG0747@1|root,COG0747@2|Bacteria,2GNKN@201174|Actinobacteria,4EGG4@85012|Streptosporangiales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_903179_1	670307.HYPDE_34523	1.21e-51	184.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,3N6E3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the helicase family. UvrD subfamily	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_82421_1	85643.Tmz1t_2591	1.21e-91	275.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2VIUV@28216|Betaproteobacteria,2KV37@206389|Rhodocyclales	206389|Rhodocyclales	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
k59_82421_2	1122599.AUGR01000006_gene3673	1.49e-33	126.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria,1XHRX@135619|Oceanospirillales	135619|Oceanospirillales	S	protein conserved in bacteria	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
k59_1079740_1	1049564.TevJSym_ad01120	3.91e-159	484.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1J5AR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	COG1643 HrpA-like helicases	hrpA	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_721332_1	1123256.KB907938_gene560	5.72e-30	116.0	COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,1RPY4@1236|Gammaproteobacteria,1X811@135614|Xanthomonadales	135614|Xanthomonadales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
k59_721332_2	1123256.KB907938_gene561	1.43e-54	187.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1X50J@135614|Xanthomonadales	135614|Xanthomonadales	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_1600813_1	867845.KI911784_gene1291	2.04e-245	693.0	COG1053@1|root,COG1053@2|Bacteria,2G5YB@200795|Chloroflexi,374WX@32061|Chloroflexia	32061|Chloroflexia	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_662713_1	768671.ThimaDRAFT_2990	2.83e-82	246.0	COG0607@1|root,COG0607@2|Bacteria,1MZ87@1224|Proteobacteria,1S98V@1236|Gammaproteobacteria,1WY49@135613|Chromatiales	135613|Chromatiales	P	PFAM Rhodanese-like	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1718452_1	479431.Namu_0308	1.94e-248	701.0	COG1263@1|root,COG1264@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,2GKPM@201174|Actinobacteria	201174|Actinobacteria	G	Phosphotransferase System	-	-	2.7.1.193,2.7.1.199,2.7.1.208	ko:K02749,ko:K02750,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804	ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111	M00265,M00266,M00267,M00268	R02738,R04111,R05199	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.1,4.A.1.1.10,4.A.1.1.15,4.A.1.1.16,4.A.1.1.2,4.A.1.1.3,4.A.1.1.4,4.A.1.1.5,4.A.1.1.7,4.A.1.1.8	-	-	PTS_EIIB,PTS_EIIC
k59_662714_1	414684.RC1_2977	2.12e-57	191.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,2TRV3@28211|Alphaproteobacteria,2JPRI@204441|Rhodospirillales	204441|Rhodospirillales	T	COG1702 Phosphate starvation-inducible protein PhoH	ybeZ	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_1253886_1	1005048.CFU_0175	7.37e-47	169.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2VIE8@28216|Betaproteobacteria,4762F@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Peptidase family M3	dcp	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_1253896_1	472759.Nhal_1290	9.38e-101	327.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1WWGW@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM ATP-dependent helicase HrpA	-	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_82470_1	187272.Mlg_1950	9.2e-50	164.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria,1WY8Z@135613|Chromatiales	135613|Chromatiales	S	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
k59_82470_2	314278.NB231_03772	1.36e-26	107.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales	135613|Chromatiales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_913773_1	278957.ABEA03000041_gene2213	2.12e-27	105.0	COG0359@1|root,COG0359@2|Bacteria,46SYE@74201|Verrucomicrobia,3K82A@414999|Opitutae	414999|Opitutae	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
k59_913773_2	653733.Selin_1470	1.61e-09	57.0	COG0629@1|root,COG0629@2|Bacteria	2|Bacteria	L	single-stranded DNA binding	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_1606663_1	713586.KB900536_gene2461	7.46e-13	77.4	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1WXQN@135613|Chromatiales	135613|Chromatiales	EQ	PFAM Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k59_1135662_1	765912.Thimo_2643	3.03e-190	543.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1WWAI@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,Pribosyltran
k59_913780_1	700508.D174_15265	1.23e-05	48.1	COG1020@1|root,COG1020@2|Bacteria,2GPHZ@201174|Actinobacteria,23298@1762|Mycobacteriaceae	201174|Actinobacteria	I	Belongs to the long-chain O-acyltransferase family	-	-	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
k59_913780_2	742823.HMPREF9465_00624	5.46e-25	103.0	COG2021@1|root,COG2021@2|Bacteria,1QU6N@1224|Proteobacteria,2WGNS@28216|Betaproteobacteria,4PS3G@995019|Sutterellaceae	28216|Betaproteobacteria	E	Alpha/beta hydrolase family	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
k59_433481_1	331869.BAL199_26821	9.46e-66	219.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,4BPFM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	phbC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
k59_270335_1	479434.Sthe_0790	7.81e-09	57.4	COG0511@1|root,COG0511@2|Bacteria,2G94M@200795|Chloroflexi,27YJ8@189775|Thermomicrobia	189775|Thermomicrobia	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	-	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
k59_270335_2	305900.GV64_08605	2.33e-61	192.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,1S3PX@1236|Gammaproteobacteria,1XJM2@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
k59_1324999_1	1123322.KB904658_gene1288	8.72e-60	194.0	COG0182@1|root,COG0182@2|Bacteria,2GJJA@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
k59_1017269_1	413404.Rmag_0862	2.84e-25	103.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1J5XD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	dsrL	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,Fer4_9,NADH_4Fe-4S,Pyr_redox_2
k59_1017269_2	1123400.KB904780_gene1910	7.41e-30	113.0	2E6CU@1|root,3310G@2|Bacteria,1NBK1@1224|Proteobacteria,1S5EP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	dsrJ	-	-	-	-	-	-	-	-	-	-	-	-
k59_1017269_3	1255043.TVNIR_0850	1.55e-82	251.0	COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,1RRYZ@1236|Gammaproteobacteria,1WVZM@135613|Chromatiales	135613|Chromatiales	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_7
k59_1432616_1	1415779.JOMH01000001_gene3134	1.24e-62	200.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1S670@1236|Gammaproteobacteria,1X9PH@135614|Xanthomonadales	135614|Xanthomonadales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_1432616_2	662479.C440_14339	9.31e-07	50.1	COG0444@1|root,arCOG00181@2157|Archaea,2XSTM@28890|Euryarchaeota,23SR3@183963|Halobacteria	183963|Halobacteria	E	COG0444 ABC-type dipeptide oligopeptide nickel transport system, ATPase component	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1606677_2	869210.Marky_0572	9.22e-36	132.0	COG0626@1|root,COG0626@2|Bacteria,1WK1T@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM Cys Met metabolism PLP-dependent enzyme	-	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_668792_1	292415.Tbd_0568	3.2e-36	140.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,1KRKZ@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
k59_1087759_1	1380354.JIAN01000007_gene88	8.46e-54	189.0	COG1199@1|root,COG1199@2|Bacteria,2GKT8@201174|Actinobacteria,4F0ZQ@85016|Cellulomonadaceae	201174|Actinobacteria	KL	HELICc2	dinG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
k59_316499_1	670307.HYPDE_22573	1.4e-56	197.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,3N63C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Penicillin-binding protein, 1A family	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
k59_913819_1	1322246.BN4_10802	2.13e-19	90.5	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WKS0@28221|Deltaproteobacteria,2M7YU@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_782377_1	270374.MELB17_15756	4.4e-42	144.0	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,1S40D@1236|Gammaproteobacteria,467CU@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	adenosyltransferase	pduO	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans,Haem_degrading
k59_1607413_1	519989.ECTPHS_00060	1.45e-109	339.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales	135613|Chromatiales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_610363_1	1123065.ATWL01000007_gene3259	3.79e-199	583.0	COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_93536_3	395495.Lcho_0420	3.94e-29	110.0	COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,2WGT1@28216|Betaproteobacteria,1KPCN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_974376_1	314265.R2601_00770	1.4e-58	189.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2TT2Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_669577_1	991905.SL003B_2904	7.23e-84	259.0	COG1275@1|root,COG1275@2|Bacteria,1MVPG@1224|Proteobacteria,2U072@28211|Alphaproteobacteria,4BSFS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Voltage-dependent anion channel	tehA	-	-	ko:K03304	-	-	-	-	ko00000,ko02000	2.A.16.1	-	-	SLAC1
k59_1088734_1	639030.JHVA01000001_gene1264	5.21e-31	118.0	COG3126@1|root,COG3187@1|root,COG3126@2|Bacteria,COG3187@2|Bacteria,3Y8W7@57723|Acidobacteria	57723|Acidobacteria	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META,YscW
k59_93539_1	1123393.KB891316_gene1488	9.28e-13	68.6	COG2920@1|root,COG2920@2|Bacteria,1N3YM@1224|Proteobacteria,2W3KZ@28216|Betaproteobacteria,1KT63@119069|Hydrogenophilales	119069|Hydrogenophilales	P	DsrC like protein	-	-	-	-	-	-	-	-	-	-	-	-	DsrC
k59_915344_1	1234364.AMSF01000025_gene3638	5.4e-67	230.0	COG0591@1|root,COG0642@1|root,COG0784@1|root,COG0591@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,1X43U@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
k59_317318_1	237609.PSAKL28_31720	5.95e-106	327.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,1RZMQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Recombinase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
k59_387037_1	1286106.MPL1_00757	3.38e-79	248.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,461TR@72273|Thiotrichales	72273|Thiotrichales	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_1497325_2	338963.Pcar_0067	1.22e-44	150.0	COG0517@1|root,COG0517@2|Bacteria,1QQRM@1224|Proteobacteria,42TVT@68525|delta/epsilon subdivisions,2WQBQ@28221|Deltaproteobacteria,43VA2@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_1497325_3	5911.EAR92099	1.15e-25	111.0	28M59@1|root,2QTN6@2759|Eukaryota,3ZC89@5878|Ciliophora	5878|Ciliophora	S	Lipase maturation factor	-	-	-	-	-	-	-	-	-	-	-	-	LMF1
k59_1326579_1	56780.SYN_01627	4.74e-84	262.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,42KZG@68525|delta/epsilon subdivisions,2WIQ5@28221|Deltaproteobacteria,2MRH5@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
k59_271492_1	396588.Tgr7_2114	5.13e-62	216.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales	135613|Chromatiales	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_141351_1	1249627.D779_4058	1.19e-24	95.9	2BRPS@1|root,32KPD@2|Bacteria,1PAWY@1224|Proteobacteria,1STPX@1236|Gammaproteobacteria,1X1Q8@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1136398_1	1125863.JAFN01000001_gene3206	3.98e-49	171.0	COG2159@1|root,COG2159@2|Bacteria,1QZ3W@1224|Proteobacteria,42PKB@68525|delta/epsilon subdivisions,2WM59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_38112_1	1123392.AQWL01000002_gene2006	8.47e-07	50.8	2DP15@1|root,3303T@2|Bacteria,1PYYU@1224|Proteobacteria,2WE2T@28216|Betaproteobacteria,1KT3Q@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Domain of unknown function (DUF4426)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4426
k59_38112_2	1158165.KB898873_gene598	2.45e-36	129.0	COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria,1WXWD@135613|Chromatiales	135613|Chromatiales	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
k59_271503_1	555779.Dthio_PD0626	4.08e-24	102.0	COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,42U06@68525|delta/epsilon subdivisions,2WP2C@28221|Deltaproteobacteria,2M7QN@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1783743_1	880072.Desac_2265	5.34e-87	274.0	COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,42M49@68525|delta/epsilon subdivisions,2WJ5G@28221|Deltaproteobacteria,2MR17@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Elongation factor Tu domain 2	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
k59_915379_1	670307.HYPDE_38078	1.35e-135	391.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2TRD8@28211|Alphaproteobacteria,3N6K8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_93582_1	1035308.AQYY01000001_gene2479	9.6e-41	154.0	COG1074@1|root,COG1074@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase activity	recB	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1549318_1	1192868.CAIU01000021_gene3149	4.23e-39	149.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,43H7J@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	penicillin-binding protein	pbpC	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
k59_199933_1	187272.Mlg_1378	3.04e-66	224.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1WX5E@135613|Chromatiales	135613|Chromatiales	M	PFAM Lytic	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
k59_1373395_1	1033802.SSPSH_002045	2.79e-61	203.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Mg2 and Co2 transporter CorB	yfjD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1497356_1	1121933.AUHH01000043_gene3559	1.6e-124	362.0	COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria	201174|Actinobacteria	L	PFAM IstB domain protein ATP-binding protein	dnaA_2	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_845586_1	765911.Thivi_2824	4.32e-30	121.0	COG5380@1|root,COG5380@2|Bacteria,1N6UY@1224|Proteobacteria,1S03R@1236|Gammaproteobacteria,1WX19@135613|Chromatiales	135613|Chromatiales	O	lipid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1262882_1	1380391.JIAS01000013_gene3805	1.01e-12	78.2	COG2982@1|root,COG2982@2|Bacteria,1RARX@1224|Proteobacteria,2U6TW@28211|Alphaproteobacteria,2JRRG@204441|Rhodospirillales	204441|Rhodospirillales	M	AsmA-like C-terminal region	-	-	-	ko:K07290	-	-	-	-	ko00000	9.B.121	-	-	AsmA,AsmA_2
k59_551770_1	313603.FB2170_12286	5.29e-130	382.0	COG0059@1|root,COG0059@2|Bacteria,4NFYV@976|Bacteroidetes,1HYM2@117743|Flavobacteriia,2PGMX@252356|Maribacter	976|Bacteroidetes	EH	Acetohydroxy acid isomeroreductase, catalytic domain	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
k59_317356_1	1304865.JAGF01000001_gene2856	2.98e-85	263.0	COG3239@1|root,COG3239@2|Bacteria,2GJKF@201174|Actinobacteria,4F1WW@85016|Cellulomonadaceae	201174|Actinobacteria	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
k59_387105_1	313628.LNTAR_04151	2.7e-18	87.0	COG1349@1|root,COG1349@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	3.6.4.12	ko:K02444,ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	AlbA_2,DUF1670,DeoRC,HATPase_c_4,HTH_DeoR
k59_1088786_1	690850.Desaf_0046	6.7e-105	321.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2WJ5B@28221|Deltaproteobacteria,2M7XR@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	PFAM Glutamyl glutaminyl-tRNA synthetase, class Ic, catalytic	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C
k59_915421_1	349521.HCH_04804	3e-143	422.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1XHPQ@135619|Oceanospirillales	135619|Oceanospirillales	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_199948_1	675817.VDA_003436	3.57e-64	213.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1XSMB@135623|Vibrionales	135623|Vibrionales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA1	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_199948_2	1123261.AXDW01000029_gene3612	8.83e-49	160.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,1X56E@135614|Xanthomonadales	135614|Xanthomonadales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_1433468_1	1249627.D779_1852	4.98e-88	287.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales	135613|Chromatiales	E	Vitamin B12 dependent methionine synthase activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_669616_1	1089544.KB912942_gene2769	5.46e-05	45.8	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,4E12D@85010|Pseudonocardiales	201174|Actinobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_669616_2	1089544.KB912942_gene2770	1.35e-149	429.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4DZDF@85010|Pseudonocardiales	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_387118_2	471853.Bcav_1253	2.82e-35	126.0	2DPN9@1|root,332RH@2|Bacteria,2GRGX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_845596_1	1396141.BATP01000039_gene1381	1.74e-59	209.0	COG4630@1|root,COG4631@1|root,COG4630@2|Bacteria,COG4631@2|Bacteria,46Z71@74201|Verrucomicrobia,2IWQ8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	F	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_38163_1	439235.Dalk_5064	1.18e-19	90.1	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Fer4_4,Fer4_7,NAD_binding_8,Pyr_redox_2
k59_38163_2	439235.Dalk_3063	1.8e-27	103.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42RK0@68525|delta/epsilon subdivisions,2WNZZ@28221|Deltaproteobacteria,2MK05@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
k59_1088792_1	1077972.ARGLB_094_00160	5.87e-16	78.2	COG3064@1|root,COG3271@1|root,COG3064@2|Bacteria,COG3271@2|Bacteria,2H973@201174|Actinobacteria	201174|Actinobacteria	M	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I36,Transglycosylas,VCBS
k59_1088792_2	290399.Arth_3185	2.04e-05	48.9	COG1404@1|root,COG3867@1|root,COG4733@1|root,COG5184@1|root,COG1404@2|Bacteria,COG3867@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	3.2.1.14,3.2.1.23,3.2.1.89	ko:K01183,ko:K01190,ko:K01224	ko00052,ko00511,ko00520,ko00600,ko01100,map00052,map00511,map00520,map00600,map01100	-	R01105,R01206,R01678,R02334,R03355,R04783,R06114	RC00049,RC00452,RC00467	ko00000,ko00001,ko01000	-	GH18	-	B_lectin,F5_F8_type_C,RCC1,RicinB_lectin_2,SLH
k59_1854982_1	1033802.SSPSH_002855	2.52e-10	56.6	COG3197@1|root,COG3197@2|Bacteria	2|Bacteria	P	Cytochrome oxidase maturation protein	ccoS	-	-	-	-	-	-	-	-	-	-	-	FixS
k59_1854982_2	207954.MED92_03797	1.52e-60	213.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XHFD@135619|Oceanospirillales	135619|Oceanospirillales	P	P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_1136441_1	187272.Mlg_0869	3.33e-55	193.0	COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,1S3FX@1236|Gammaproteobacteria,1X0GV@135613|Chromatiales	135613|Chromatiales	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1433482_2	1454010.JEOE01000021_gene2548	4.6e-39	132.0	COG0198@1|root,COG0198@2|Bacteria,2IKP2@201174|Actinobacteria,4F1DR@85016|Cellulomonadaceae	201174|Actinobacteria	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
k59_1497382_2	420662.Mpe_A0156	9.16e-10	60.5	2DB8N@1|root,2Z7S9@2|Bacteria,1PZ8J@1224|Proteobacteria,2VSMZ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF3047)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3047
k59_1018036_1	590998.Celf_2134	6.26e-94	281.0	COG0518@1|root,COG0518@2|Bacteria,2GNA6@201174|Actinobacteria	201174|Actinobacteria	F	glutamine amidotransferase	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,Methyltransf_11
k59_206897_1	1049564.TevJSym_aa02290	5.52e-70	236.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1J58G@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_324140_1	1265503.KB905164_gene2039	1.62e-46	164.0	COG0668@1|root,COG1340@1|root,COG0668@2|Bacteria,COG1340@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,2Q7JN@267889|Colwelliaceae	1236|Gammaproteobacteria	M	Mechanosensitive ion channel	VP2168	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel
k59_324140_2	1123377.AUIV01000012_gene702	3.83e-67	223.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1X3IX@135614|Xanthomonadales	135614|Xanthomonadales	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1556052_1	760142.Hipma_1517	1.33e-43	151.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,42QX8@68525|delta/epsilon subdivisions,2WMNR@28221|Deltaproteobacteria,2M71A@213113|Desulfurellales	28221|Deltaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_788749_1	1123401.JHYQ01000006_gene148	1.71e-75	250.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,45ZPW@72273|Thiotrichales	72273|Thiotrichales	P	heavy metal translocating P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_47317_2	756272.Plabr_2921	1.92e-34	121.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_1866706_1	768671.ThimaDRAFT_0726	1.9e-104	315.0	COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,1RXX2@1236|Gammaproteobacteria,1WX24@135613|Chromatiales	135613|Chromatiales	S	VWA-like domain (DUF2201)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2201,DUF2201_N
k59_986252_1	1123368.AUIS01000007_gene2819	6.37e-127	369.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,2NCEM@225057|Acidithiobacillales	1236|Gammaproteobacteria	BQ	Histone deacetylase domain	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
k59_617125_1	1110502.TMO_1355	4.58e-113	347.0	COG5309@1|root,COG5309@2|Bacteria,1MWJJ@1224|Proteobacteria,2U19Q@28211|Alphaproteobacteria,2JQVV@204441|Rhodospirillales	204441|Rhodospirillales	G	beta (1-6) glucans synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_17
k59_735252_1	1123392.AQWL01000008_gene1236	1.06e-91	299.0	COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,2VI5M@28216|Betaproteobacteria	28216|Betaproteobacteria	S	homolog of phage Mu protein gp47	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
k59_558500_1	272943.RSP_1729	1.54e-60	189.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2U6ZH@28211|Alphaproteobacteria,1FBR1@1060|Rhodobacter	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
k59_558500_2	1282876.BAOK01000001_gene1733	3.63e-37	127.0	COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,2UC01@28211|Alphaproteobacteria,4BQQD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
k59_852305_1	765912.Thimo_1580	1.37e-123	379.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1RQK9@1236|Gammaproteobacteria,1WWPF@135613|Chromatiales	135613|Chromatiales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.6	ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1096087_1	452652.KSE_68510	6.46e-34	132.0	COG0730@1|root,COG0730@2|Bacteria,2I5VT@201174|Actinobacteria,2M5BE@2063|Kitasatospora	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_1440258_1	203267.TWT_550	1.81e-32	115.0	COG0185@1|root,COG0185@2|Bacteria,2IKMS@201174|Actinobacteria	201174|Actinobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_1440258_2	953739.SVEN_4384	2.02e-55	175.0	COG0091@1|root,COG0091@2|Bacteria,2IM3J@201174|Actinobacteria	201174|Actinobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_617133_1	714943.Mucpa_6196	1.37e-08	59.3	COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes,1INN3@117747|Sphingobacteriia	976|Bacteroidetes	E	PFAM Aminotransferase class I and II	bioF	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_617133_2	526227.Mesil_2958	3.03e-44	153.0	COG0451@1|root,COG0451@2|Bacteria,1WNCR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	PFAM NAD dependent epimerase dehydratase family	-	-	1.1.1.203	ko:K18981	ko00053,map00053	-	R10841	RC00066	ko00000,ko00001,ko01000	-	-	-	Epimerase
k59_852306_2	105559.Nwat_0748	2.97e-44	154.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNXA@1236|Gammaproteobacteria,1WWTQ@135613|Chromatiales	135613|Chromatiales	E	PFAM aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_558504_1	471853.Bcav_2349	9.58e-124	368.0	COG0504@1|root,COG0504@2|Bacteria,2GJ13@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1699	CTP_synth_N,GATase
k59_735263_2	1147.D082_15160	8.57e-05	46.2	COG0025@1|root,COG0589@1|root,COG0025@2|Bacteria,COG0589@2|Bacteria,1G1BR@1117|Cyanobacteria	1117|Cyanobacteria	PT	PFAM Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,Usp
k59_280268_1	1121937.AUHJ01000003_gene3134	2.44e-25	107.0	COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,1RPGN@1236|Gammaproteobacteria,465RT@72275|Alteromonadaceae	1236|Gammaproteobacteria	MU	COG1538 Outer membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1142228_1	1304275.C41B8_10328	0.000219	44.7	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RM9H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG0767 ABC-type transport system involved in resistance to organic solvents, permease component	mlaE	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_1142228_2	519989.ECTPHS_01719	4.87e-42	146.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1WW98@135613|Chromatiales	135613|Chromatiales	Q	PFAM ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_735271_1	762376.AXYL_04599	4.49e-42	145.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,2VH8U@28216|Betaproteobacteria,3T2AH@506|Alcaligenaceae	28216|Betaproteobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
k59_105246_1	56780.SYN_00126	1.06e-15	77.4	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ4Z@28221|Deltaproteobacteria,2MR4Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	NU	Type IV secretion-system coupling protein DNA-binding domain	pilT1	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_105246_2	497964.CfE428DRAFT_5641	6.1e-53	176.0	COG2805@1|root,COG2805@2|Bacteria,46SY2@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	PFAM type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_1504858_1	866774.HMPREF9248_0813	0.000341	50.4	COG0826@1|root,COG0826@2|Bacteria,2GKTB@201174|Actinobacteria,4CU8Z@84998|Coriobacteriia	84998|Coriobacteriia	O	Peptidase, U32 family	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
k59_852338_1	765910.MARPU_08835	1.29e-22	97.8	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,1WX7U@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_852338_2	1109445.AGSX01000019_gene1748	1.43e-84	263.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,1Z09G@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	L	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase	rarA	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_1205189_1	1121918.ARWE01000001_gene50	1.99e-41	159.0	COG3291@1|root,COG3420@1|root,COG3291@2|Bacteria,COG3420@2|Bacteria,1Q5XI@1224|Proteobacteria,437EC@68525|delta/epsilon subdivisions,2X2KQ@28221|Deltaproteobacteria,43VY4@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1023699_1	1232410.KI421419_gene2478	2.8e-175	506.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42N5M@68525|delta/epsilon subdivisions,2WIIV@28221|Deltaproteobacteria,43RYP@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Aconitase C-terminal domain	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2763	Aconitase,Aconitase_C
k59_986337_1	471853.Bcav_3155	1.75e-154	467.0	COG0085@1|root,COG0085@2|Bacteria,2GJ81@201174|Actinobacteria	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_676687_1	472759.Nhal_0935	3.57e-79	251.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1S14K@1236|Gammaproteobacteria,1X0FN@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX2	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_927228_1	1408418.JNJH01000028_gene1475	3.98e-41	142.0	COG1943@1|root,COG1943@2|Bacteria,1QZS9@1224|Proteobacteria,2TYDM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
k59_398822_1	1237149.C900_02923	8.36e-68	218.0	COG0304@1|root,COG0304@2|Bacteria,4NFC8@976|Bacteroidetes,47N4W@768503|Cytophagia	976|Bacteroidetes	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1789577_1	765913.ThidrDRAFT_3637	8.59e-86	261.0	COG0119@1|root,COG0119@2|Bacteria,1MVQG@1224|Proteobacteria,1RPPW@1236|Gammaproteobacteria,1WW82@135613|Chromatiales	135613|Chromatiales	E	PFAM Pyruvate carboxyltransferase	-	-	4.1.3.39	ko:K01666	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R00750	RC00307,RC00371	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
k59_1732608_1	375286.mma_0447	2.81e-17	84.0	COG2010@1|root,COG4654@1|root,COG2010@2|Bacteria,COG4654@2|Bacteria,1QVK1@1224|Proteobacteria	1224|Proteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	soxD	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrome_CBB3
k59_1732608_2	543913.D521_0985	6.23e-29	114.0	COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,2VI1T@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Molybdopterin binding	soxC	-	-	ko:K17225	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Mo-co_dimer,Oxidored_molyb
k59_1675248_1	292415.Tbd_0601	5.49e-93	282.0	COG1085@1|root,COG1085@2|Bacteria,1MU3E@1224|Proteobacteria,2VN1T@28216|Betaproteobacteria,1KSVG@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Domain of unknown function (DUF4931)	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	-
k59_1675248_2	458817.Shal_2321	7.17e-20	87.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,2QAC6@267890|Shewanellaceae	1236|Gammaproteobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008840,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_2492,iJN746.PP_1237,iYL1228.KPN_02812	DHDPS
k59_986363_1	566466.NOR53_2219	6.23e-22	103.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1RQJX@1236|Gammaproteobacteria,1J8V9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	Q	Protein of unknown function (DUF1298)	atfA1	-	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
k59_1142271_1	1304865.JAGF01000001_gene2859	9.43e-15	79.0	COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4F2PZ@85016|Cellulomonadaceae	201174|Actinobacteria	L	Helix-hairpin-helix motif	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
k59_1023715_1	754476.Q7A_1603	3.06e-84	258.0	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,1RMH5@1236|Gammaproteobacteria,4617A@72273|Thiotrichales	72273|Thiotrichales	E	Belongs to the arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
k59_105321_1	1304883.KI912532_gene1931	2.57e-99	306.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2VH3P@28216|Betaproteobacteria,2KVZ5@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_1205212_1	420324.KI911965_gene1167	5.65e-39	137.0	COG0454@1|root,COG0456@2|Bacteria,1N6RY@1224|Proteobacteria,2TSVU@28211|Alphaproteobacteria,1JV23@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	PFAM GCN5-related N-acetyltransferase	MA20_25245	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1205212_2	426117.M446_2664	2.18e-18	79.7	COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2TQZM@28211|Alphaproteobacteria,1JRES@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
k59_558568_1	1121861.KB899940_gene3722	1.49e-182	513.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria,2JV2N@204441|Rhodospirillales	204441|Rhodospirillales	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_441363_1	653733.Selin_1868	4.88e-12	67.4	COG2111@1|root,COG2111@2|Bacteria	2|Bacteria	P	Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	DUF4040,MnhB
k59_441363_2	713586.KB900536_gene2686	1.73e-14	70.1	COG1563@1|root,COG1563@2|Bacteria	2|Bacteria	P	Domain of unknown function (DUF4040)	mnhB	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB
k59_441363_3	318167.Sfri_2737	3.25e-20	83.6	COG1320@1|root,COG1320@2|Bacteria,1N75I@1224|Proteobacteria,1SCHB@1236|Gammaproteobacteria,2QE0F@267890|Shewanellaceae	1236|Gammaproteobacteria	P	Na+/H+ antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_986378_1	1049564.TevJSym_ac01960	2.91e-109	317.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
k59_735344_1	1120999.JONM01000002_gene607	6.35e-12	70.9	COG2199@1|root,COG3706@2|Bacteria,1RD8D@1224|Proteobacteria,2VS5N@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_852378_1	593907.Celgi_2506	1.02e-63	206.0	COG1305@1|root,COG1305@2|Bacteria,2GMD7@201174|Actinobacteria	201174|Actinobacteria	E	transglutaminase	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
k59_324242_1	1408422.JHYF01000003_gene927	4.91e-65	224.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,36DHP@31979|Clostridiaceae	186801|Clostridia	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_927283_1	1415780.JPOG01000001_gene1824	2.82e-45	167.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,1S4M3@1236|Gammaproteobacteria,1X9CV@135614|Xanthomonadales	135614|Xanthomonadales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
k59_148437_1	1122603.ATVI01000007_gene1660	8.34e-43	155.0	COG0642@1|root,COG2205@2|Bacteria,1QTVU@1224|Proteobacteria,1RPFY@1236|Gammaproteobacteria,1XD6R@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase-like ATPases	-	-	2.7.13.3	ko:K07637	ko01503,ko02020,map01503,map02020	M00444,M00709,M00721,M00723,M00724,M00744	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HATPase_c
k59_1142288_1	522306.CAP2UW1_1910	2.76e-164	478.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VZHX@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1205235_1	326427.Cagg_3834	3.01e-71	235.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi,3756Y@32061|Chloroflexia	32061|Chloroflexia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_1338626_1	519989.ECTPHS_05591	2.14e-93	288.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1WVXY@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_207804_1	1500257.JQNM01000004_gene143	1.03e-34	140.0	COG0457@1|root,COG0607@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0607@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,HEAT_2,Rhodanese,TPR_16,TPR_19,TPR_8,TolB_N
k59_1676128_1	1125863.JAFN01000001_gene1735	6.07e-111	327.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,42RHF@68525|delta/epsilon subdivisions,2WNRC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1206028_1	765911.Thivi_3738	1.2e-70	236.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1WVV0@135613|Chromatiales	135613|Chromatiales	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_1097126_1	269799.Gmet_2767	4.89e-102	320.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42Y60@68525|delta/epsilon subdivisions,2WUR1@28221|Deltaproteobacteria,43T95@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_928626_1	446469.Sked_05120	2.98e-53	191.0	COG1139@1|root,COG1139@2|Bacteria,2GJDR@201174|Actinobacteria	201174|Actinobacteria	C	Iron-sulfur cluster binding protein	lutB	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
k59_1733403_1	626887.J057_09431	4.2e-30	113.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1S5Y0@1236|Gammaproteobacteria,467SF@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	gtrA	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_1733403_2	768671.ThimaDRAFT_1995	2.3e-28	106.0	COG4783@1|root,COG4783@2|Bacteria,1N76P@1224|Proteobacteria,1T4CE@1236|Gammaproteobacteria,1X1B8@135613|Chromatiales	135613|Chromatiales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1733403_3	1033802.SSPSH_003461	4.06e-61	205.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA	trkH	GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031224,GO:0031226,GO:0031420,GO:0034220,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046983,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	iPC815.YPO3762,iSFV_1184.SFV_3651	TrkH
k59_48954_1	945713.IALB_1660	1.25e-36	130.0	COG2391@1|root,COG2391@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_281701_1	1340493.JNIF01000003_gene4121	8.94e-18	89.4	COG4219@1|root,COG4219@2|Bacteria,3Y301@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1615197_2	1123400.KB904791_gene127	3.76e-93	278.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria,45ZXZ@72273|Thiotrichales	72273|Thiotrichales	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodB	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
k59_1615197_3	1120973.AQXL01000119_gene533	4.23e-97	302.0	COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,4HADJ@91061|Bacilli,279NS@186823|Alicyclobacillaceae	91061|Bacilli	L	IMS family HHH motif	dinB	GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0050896	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k59_1733407_1	1131814.JAFO01000001_gene39	1.2e-47	176.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,3F11N@335928|Xanthobacteraceae	28211|Alphaproteobacteria	I	Biotin carboxylase C-terminal domain	MA20_30205	-	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_928645_1	319236.JCM19294_1011	3.96e-26	108.0	COG0626@1|root,COG0626@2|Bacteria,4PKE6@976|Bacteroidetes,1IJ8Q@117743|Flavobacteriia,3HJDI@363408|Nonlabens	976|Bacteroidetes	E	Cys/Met metabolism PLP-dependent enzyme	-	-	4.4.1.8	ko:K01760	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_106734_1	96561.Dole_2741	8.12e-42	142.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,42RJQ@68525|delta/epsilon subdivisions,2WNDS@28221|Deltaproteobacteria,2MJTB@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_1024450_1	765420.OSCT_1289	1.71e-73	224.0	COG0041@1|root,COG0041@2|Bacteria,2G6JS@200795|Chloroflexi,375UD@32061|Chloroflexia	32061|Chloroflexia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
k59_1790344_1	1385519.N801_16075	3.79e-143	415.0	COG1051@1|root,COG1051@2|Bacteria,2I2P7@201174|Actinobacteria,4FJZ0@85021|Intrasporangiaceae	201174|Actinobacteria	F	Pfam:DUF2029	-	-	-	-	-	-	-	-	-	-	-	-	GT87
k59_1505921_1	570952.ATVH01000013_gene2859	9.88e-11	58.9	COG0745@1|root,COG0745@2|Bacteria,1MZ8W@1224|Proteobacteria,2U9PK@28211|Alphaproteobacteria,2JTJJ@204441|Rhodospirillales	204441|Rhodospirillales	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_442179_1	292415.Tbd_0990	3.57e-06	48.9	COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,2VHI6@28216|Betaproteobacteria,1KRJA@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
k59_48990_1	1123368.AUIS01000009_gene2489	2.42e-57	199.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,2NC1J@225057|Acidithiobacillales	225057|Acidithiobacillales	H	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_1562691_2	713586.KB900536_gene1714	4.92e-58	187.0	COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria,1WXWD@135613|Chromatiales	135613|Chromatiales	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
k59_289387_1	644282.Deba_2944	4.08e-79	263.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_623766_1	319003.Bra1253DRAFT_06189	7.77e-30	121.0	COG0154@1|root,COG0154@2|Bacteria,1MWWQ@1224|Proteobacteria,2TSN9@28211|Alphaproteobacteria,3JS0D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_1277892_1	498761.HM1_1149	1.07e-09	59.3	COG0279@1|root,COG0279@2|Bacteria,1V5W5@1239|Firmicutes,24INX@186801|Clostridia	186801|Clostridia	G	isomerase	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
k59_1277892_2	765912.Thimo_0207	1.01e-17	87.4	COG0457@1|root,COG0457@2|Bacteria,1MXK4@1224|Proteobacteria,1RNFM@1236|Gammaproteobacteria,1WXT3@135613|Chromatiales	135613|Chromatiales	S	Oxygen tolerance	-	-	-	-	-	-	-	-	-	-	-	-	BatD
k59_331029_1	1417296.U879_20780	1.03e-91	275.0	COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,2VFYH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
k59_1739288_1	525245.HMPREF0044_1127	1.17e-60	208.0	COG2966@1|root,COG3610@1|root,COG2966@2|Bacteria,COG3610@2|Bacteria,2HJJ3@201174|Actinobacteria,4D3P6@85005|Actinomycetales	201174|Actinobacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	ThrE
k59_996119_1	717785.HYPMC_3829	2.26e-180	517.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2TR1R@28211|Alphaproteobacteria,3N6IY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_1739290_1	261292.Nit79A3_3046	5.02e-33	127.0	COG1249@1|root,COG1249@2|Bacteria,1MXQ3@1224|Proteobacteria,2VK4G@28216|Betaproteobacteria,37273@32003|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1739290_2	768671.ThimaDRAFT_1207	6.04e-26	107.0	COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1WWFZ@135613|Chromatiales	135613|Chromatiales	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase
k59_1876908_1	1523503.JPMY01000002_gene3837	5.4e-61	197.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,1RPYX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	COG1214 Inactive homolog of metal-dependent proteases	yeaZ	GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
k59_623781_1	471853.Bcav_1874	3.91e-39	147.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_996148_1	1108045.GORHZ_118_00080	3.31e-241	665.0	COG2048@1|root,COG2048@2|Bacteria	2|Bacteria	C	Heterodisulfide reductase, subunit B	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_447960_1	2074.JNYD01000009_gene5147	1.16e-46	158.0	COG1309@1|root,COG1309@2|Bacteria,2GM0B@201174|Actinobacteria,4E3WE@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_115300_1	1089553.Tph_c03600	2.2e-46	156.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FUA@68295|Thermoanaerobacterales	186801|Clostridia	S	B12 binding domain	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
k59_1103410_1	42345.XP_008810250.1	7.15e-11	62.0	COG1640@1|root,2QU40@2759|Eukaryota,37QV5@33090|Viridiplantae,3G7Z8@35493|Streptophyta,3KVEM@4447|Liliopsida	35493|Streptophyta	G	4-alpha-glucanotransferase	DPE1	GO:0000023,GO:0000025,GO:0000272,GO:0003674,GO:0003824,GO:0004133,GO:0004134,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005982,GO:0005983,GO:0005984,GO:0005996,GO:0006006,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009311,GO:0009313,GO:0009501,GO:0009507,GO:0009536,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019318,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0055114,GO:0071704,GO:1901575	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_1512091_1	243231.GSU2101	1.48e-85	275.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria,43TNZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Glycine radical	-	-	2.3.1.54,4.1.99.11,4.3.99.4	ko:K00656,ko:K07540,ko:K20038	ko00620,ko00623,ko00640,ko00650,ko01100,ko01120,ko01220,map00620,map00623,map00640,map00650,map01100,map01120,map01220	M00418	R00212,R05598,R06987	RC00004,RC01181,RC01433,RC01434,RC02742,RC02833	ko00000,ko00001,ko00002,ko01000	-	-	-	Gly_radical,PFL-like
k59_565212_1	485915.Dret_1795	9.35e-83	257.0	COG0475@1|root,COG0475@2|Bacteria,1RFKE@1224|Proteobacteria,43B2P@68525|delta/epsilon subdivisions,2X6GM@28221|Deltaproteobacteria,2M9P0@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1740452_1	1121935.AQXX01000109_gene480	1.33e-104	332.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1XHSN@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_410402_1	446466.Cfla_1633	1.23e-155	447.0	COG1350@1|root,COG1350@2|Bacteria,2GP7D@201174|Actinobacteria	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB2	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1740453_1	1038862.KB893895_gene7163	1.43e-22	96.7	COG1075@1|root,COG1075@2|Bacteria,1NJNA@1224|Proteobacteria,2TSQC@28211|Alphaproteobacteria,3JSU2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Alpha beta hydrolase	MA20_16715	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Lipase_2
k59_156370_1	1380394.JADL01000002_gene1228	2.21e-95	292.0	COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,2TRTR@28211|Alphaproteobacteria,2JR46@204441|Rhodospirillales	204441|Rhodospirillales	Q	Homospermidine synthase	hss	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_997791_1	1089546.AQUI01000002_gene4529	4.03e-68	226.0	COG4585@1|root,COG4585@2|Bacteria,2HF0E@201174|Actinobacteria,40AC3@622450|Actinopolysporales	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07778	ko02020,map02020	M00479	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HisKA_3
k59_1447726_1	596154.Alide2_2291	2.33e-64	210.0	COG1711@1|root,COG1711@2|Bacteria,1RIA0@1224|Proteobacteria,2VIHJ@28216|Betaproteobacteria,4AB02@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3014)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3014
k59_1513284_1	1122604.JONR01000055_gene4119	4.45e-38	130.0	COG1146@1|root,COG1146@2|Bacteria,1NCXI@1224|Proteobacteria	1224|Proteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6,Fer4_7
k59_1279113_1	1157632.AQWQ01000008_gene5078	1.2e-23	102.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_566315_1	696747.NIES39_L06140	1.6e-90	276.0	COG0179@1|root,COG0179@2|Bacteria,1G06Y@1117|Cyanobacteria,1H915@1150|Oscillatoriales	1117|Cyanobacteria	Q	COGs COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1 7-dioic acid hydratase (catechol pathway)	hpcE	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
k59_1031698_1	1385521.N803_00455	1.42e-16	78.2	COG0042@1|root,COG0042@2|Bacteria,2GJ8I@201174|Actinobacteria,4FFGK@85021|Intrasporangiaceae	201174|Actinobacteria	J	tRNA-dihydrouridine synthase	dus	GO:0008150,GO:0010565,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0080090	-	-	-	-	-	-	-	-	-	-	Dus
k59_1031698_2	367299.JOEE01000009_gene332	4.26e-85	255.0	COG4430@1|root,COG4430@2|Bacteria,2II0D@201174|Actinobacteria,4FGFM@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
k59_997806_1	28583.AMAG_05543T0	9.97e-05	46.2	COG1208@1|root,KOG1462@2759|Eukaryota,38BZJ@33154|Opisthokonta,3NXWR@4751|Fungi	4751|Fungi	J	Translation Initiation Factor	GCD1	GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005085,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005851,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0010646,GO:0010648,GO:0019222,GO:0019538,GO:0019899,GO:0031323,GO:0031326,GO:0032045,GO:0032101,GO:0032102,GO:0032104,GO:0032105,GO:0032107,GO:0032108,GO:0032268,GO:0032991,GO:0034248,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0051020,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903574,GO:1903832,GO:2000112	-	ko:K03241	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
k59_997806_2	94122.Shewana3_2005	4.47e-59	200.0	COG1922@1|root,COG2148@1|root,COG1922@2|Bacteria,COG2148@2|Bacteria,1N1HD@1224|Proteobacteria,1RP6P@1236|Gammaproteobacteria,2QAQA@267890|Shewanellaceae	1236|Gammaproteobacteria	M	TIGRFAM glycosyl transferase, WecB TagA CpsF family	gumM	-	2.4.1.187	ko:K05946,ko:K13660	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Bac_transf,Glyco_tran_WecB
k59_938564_2	1286171.EAL2_c10400	1.67e-61	209.0	COG0275@1|root,COG0682@1|root,COG0275@2|Bacteria,COG0682@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,25UQQ@186806|Eubacteriaceae	186801|Clostridia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_1212527_1	96561.Dole_1015	1.12e-41	147.0	COG1463@1|root,COG1463@2|Bacteria,1MYEF@1224|Proteobacteria,42SPY@68525|delta/epsilon subdivisions,2WP3D@28221|Deltaproteobacteria,2MPV3@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	-	-	-	ko:K02067,ko:K06192	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_859703_1	1121405.dsmv_0364	4.46e-36	123.0	COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,42VAI@68525|delta/epsilon subdivisions,2WRI4@28221|Deltaproteobacteria,2MKRV@213118|Desulfobacterales	28221|Deltaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_859703_2	1121405.dsmv_0363	1.32e-75	231.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NR9@68525|delta/epsilon subdivisions,2WKX1@28221|Deltaproteobacteria,2MHZU@213118|Desulfobacterales	28221|Deltaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1796402_1	765913.ThidrDRAFT_2808	2.23e-13	70.5	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,1RQXJ@1236|Gammaproteobacteria,1WVX1@135613|Chromatiales	135613|Chromatiales	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3708
k59_1796402_2	1049564.TevJSym_ax00040	1.29e-34	128.0	COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,1RN9U@1236|Gammaproteobacteria,1J5D1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0226 ABC-type phosphate transport system, periplasmic component	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_449061_1	640511.BC1002_6327	1.43e-48	176.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2VP1W@28216|Betaproteobacteria,1KCPK@119060|Burkholderiaceae	28216|Betaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_410432_1	1037409.BJ6T_83010	5.03e-158	446.0	COG3293@1|root,COG3293@2|Bacteria,1NCPP@1224|Proteobacteria	1224|Proteobacteria	L	Transposase proposed to express due to -1 translational frameshift at the sequence 5'-AAAAAC-3'	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
k59_743322_1	2340.JV46_14330	1.26e-25	110.0	COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_1149230_1	1089551.KE386572_gene2180	0.000636	46.6	COG0457@1|root,COG0457@2|Bacteria,1Q5MK@1224|Proteobacteria,2VBYX@28211|Alphaproteobacteria,4BT6H@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	D	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	SPOR,TPR_1,TPR_8
k59_566337_1	765913.ThidrDRAFT_2111	3.68e-92	274.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,1WWJX@135613|Chromatiales	135613|Chromatiales	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
k59_1388006_1	626887.J057_14420	3.24e-100	321.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,464YC@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG5009 Membrane carboxypeptidase penicillin-binding protein	mrcA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_332213_1	1206733.BAGC01000004_gene5882	1.86e-29	110.0	COG0599@1|root,COG0599@2|Bacteria	2|Bacteria	S	peroxiredoxin activity	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
k59_1563788_1	1033802.SSPSH_000578	1.12e-174	497.0	COG4948@1|root,COG4948@2|Bacteria,1MVFW@1224|Proteobacteria,1RYMG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	-	-	4.2.1.81	ko:K22209	-	-	-	-	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_290918_2	1254432.SCE1572_24150	5.06e-66	219.0	2DSHD@1|root,33G4R@2|Bacteria	2|Bacteria	-	-	-	-	1.13.11.33	ko:K19246	ko00590,ko01100,map00590,map01100	-	R01593	RC00561	ko00000,ko00001,ko01000	-	-	-	Lipoxygenase
k59_1740492_1	686578.AFFX01000013_gene2211	1.21e-56	192.0	COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_1740492_2	572477.Alvin_0511	2.39e-08	55.1	COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,1RXZ7@1236|Gammaproteobacteria,1WWXE@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function DUF87	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
k59_859737_1	1304865.JAGF01000001_gene1311	2.74e-97	297.0	COG0617@1|root,COG0617@2|Bacteria,2GMT1@201174|Actinobacteria,4F0T3@85016|Cellulomonadaceae	201174|Actinobacteria	J	metal-dependent phosphohydrolase HD sub domain	pcnA	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
k59_1513337_1	879212.DespoDRAFT_00272	1.01e-30	125.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,2MHQJ@213118|Desulfobacterales	28221|Deltaproteobacteria	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_1279164_1	478801.Ksed_12150	1.73e-50	170.0	COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,1ZVD7@145357|Dermacoccaceae	201174|Actinobacteria	G	ROK family	ppgK	-	2.7.1.2,2.7.1.63	ko:K00845,ko:K00886	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786,R02187,R02189	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_1447783_1	1122134.KB893650_gene323	1.65e-69	226.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1XIJ5@135619|Oceanospirillales	135619|Oceanospirillales	O	ATPase with chaperone activity	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_1621994_1	545264.KB898753_gene1780	6.01e-65	205.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,1WX1J@135613|Chromatiales	135613|Chromatiales	I	Enoyl- acyl-carrier-protein reductase NADH	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1621994_2	1163617.SCD_n01160	1.92e-152	452.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Extracellular solute-binding protein	oppA	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
k59_938630_1	906968.Trebr_1669	5.36e-24	103.0	COG0482@1|root,COG0482@2|Bacteria,2J6BI@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_1563807_1	66429.JOFL01000016_gene156	9.11e-24	100.0	COG0604@1|root,COG2185@1|root,COG0604@2|Bacteria,COG2185@2|Bacteria,2GKFF@201174|Actinobacteria	201174|Actinobacteria	C	reductase	ccrA2	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043880,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363	1.3.1.86	ko:K17829	ko00650,ko01120,ko01130,ko01200,map00650,map01120,map01130,map01200	-	R09738	RC00076	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_507827_1	403833.Pmob_0903	4.98e-07	51.6	COG2403@1|root,COG2403@2|Bacteria,2GCJ5@200918|Thermotogae	200918|Thermotogae	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_938641_2	1121405.dsmv_0075	5.43e-41	152.0	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,42MX2@68525|delta/epsilon subdivisions,2WIUV@28221|Deltaproteobacteria,2MJZI@213118|Desulfobacterales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_859760_2	550540.Fbal_0843	1.99e-19	86.7	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,1RNVU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	nucleoside triphosphate pyrophosphohydrolase	mazG	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.9	ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000	-	-	iAF1260.b2781,iBWG_1329.BWG_2516,iE2348C_1286.E2348C_3048,iEC55989_1330.EC55989_3056,iECDH10B_1368.ECDH10B_2948,iECDH1ME8569_1439.ECDH1ME8569_2691,iECH74115_1262.ECH74115_4041,iECIAI1_1343.ECIAI1_2889,iECO103_1326.ECO103_3324,iECO111_1330.ECO111_3505,iECO26_1355.ECO26_3851,iECOK1_1307.ECOK1_3155,iECP_1309.ECP_2762,iECSE_1348.ECSE_3039,iECSP_1301.ECSP_3733,iECW_1372.ECW_m2990,iECs_1301.ECs3641,iEKO11_1354.EKO11_0987,iEcDH1_1363.EcDH1_0907,iEcE24377_1341.EcE24377A_3085,iEcHS_1320.EcHS_A2925,iEcolC_1368.EcolC_0931,iG2583_1286.G2583_3433,iJO1366.b2781,iJR904.b2781,iSBO_1134.SBO_2662,iSSON_1240.SSON_2938,iSbBS512_1146.SbBS512_E3092,iUMN146_1321.UM146_02665,iUMNK88_1353.UMNK88_3464,iUTI89_1310.UTI89_C3150,iWFL_1372.ECW_m2990,iY75_1357.Y75_RS14470,iZ_1308.Z4096	MazG
k59_116962_1	477184.KYC_12153	1.16e-22	99.4	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2VNQX@28216|Betaproteobacteria,3T8QX@506|Alcaligenaceae	28216|Betaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_449118_1	1448857.JFAP01000014_gene73	1.35e-133	399.0	COG1232@1|root,COG1232@2|Bacteria,1R0KQ@1224|Proteobacteria,42NBG@68525|delta/epsilon subdivisions,2YN02@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	hemG	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_1796453_1	717231.Flexsi_0440	2.04e-77	244.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_332248_1	519989.ECTPHS_11497	2.51e-83	265.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1WWE5@135613|Chromatiales	135613|Chromatiales	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_1563818_1	367299.JOEE01000006_gene696	6.3e-101	298.0	COG0704@1|root,COG0704@2|Bacteria,2GKAD@201174|Actinobacteria,4FEIT@85021|Intrasporangiaceae	201174|Actinobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_449120_1	28229.ND2E_2947	4.32e-45	153.0	COG1845@1|root,COG1845@2|Bacteria,1RDNK@1224|Proteobacteria,1S1HC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_1104731_1	446471.Xcel_2217	6.36e-113	339.0	COG0433@1|root,COG0433@2|Bacteria,2GM12@201174|Actinobacteria,4F3GJ@85017|Promicromonosporaceae	201174|Actinobacteria	S	Domain of unknown function DUF87	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
k59_156457_1	309801.trd_0850	2.19e-11	69.7	COG0728@1|root,COG0728@2|Bacteria,2G5MD@200795|Chloroflexi,27XGY@189775|Thermomicrobia	189775|Thermomicrobia	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_507851_1	1304877.KI519400_gene1087	6.3e-06	48.5	COG3043@1|root,COG3043@2|Bacteria,1RHGD@1224|Proteobacteria,2U6Q2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Electron transfer subunit of the periplasmic nitrate reductase complex NapAB	napB	-	-	ko:K02568	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798	RC02812	ko00000,ko00001,ko00002	-	-	-	NapB
k59_507851_2	1238182.C882_3700	4.26e-26	105.0	COG0348@1|root,COG0348@2|Bacteria,1MWR5@1224|Proteobacteria,2TS5E@28211|Alphaproteobacteria,2JQVY@204441|Rhodospirillales	204441|Rhodospirillales	C	4Fe-4S binding domain	napH	-	-	ko:K02574	-	-	-	-	ko00000	-	-	-	Fer4_5,Fer4_6
k59_332259_1	267608.RSc2694	9.85e-16	78.2	COG3121@1|root,COG3121@2|Bacteria,1R4RJ@1224|Proteobacteria,2VXCK@28216|Betaproteobacteria,1KD2X@119060|Burkholderiaceae	28216|Betaproteobacteria	NU	Pili and flagellar-assembly chaperone, PapD N-terminal domain	papD	-	-	ko:K07346	-	-	-	-	ko00000,ko02035,ko02044,ko03110	-	-	-	PapD_N
k59_332259_2	1122951.ATUE01000009_gene424	0.000337	42.7	COG5430@1|root,COG5430@2|Bacteria	2|Bacteria	S	Spore Coat Protein U domain	-	-	-	-	-	-	-	-	-	-	-	-	SCPU
k59_214747_1	1279019.ARQK01000061_gene1794	4.84e-23	94.7	COG3011@1|root,COG3011@2|Bacteria,1PV30@1224|Proteobacteria,1SCCX@1236|Gammaproteobacteria,1WZJ7@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function, DUF393	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
k59_625028_1	472759.Nhal_1189	8.05e-20	90.5	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_625028_2	365044.Pnap_1606	1.24e-25	103.0	COG1295@1|root,COG1295@2|Bacteria,1NH82@1224|Proteobacteria,2VJW7@28216|Betaproteobacteria,4AAJH@80864|Comamonadaceae	28216|Betaproteobacteria	S	Virulence factor BrkB	-	-	-	-	-	-	-	-	-	-	-	-	Virul_fac_BrkB
k59_1740557_1	95619.PM1_0226365	6.33e-128	377.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_1001480_2	1123228.AUIH01000005_gene706	3.85e-08	60.5	2EC19@1|root,3360G@2|Bacteria,1N87W@1224|Proteobacteria,1S7E3@1236|Gammaproteobacteria,1XMCG@135619|Oceanospirillales	135619|Oceanospirillales	S	Peptidoglycan-binding protein, CsiV	-	-	-	-	-	-	-	-	-	-	-	-	CsiV
k59_1001480_3	380358.XALC_2066	8.53e-32	125.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1X4J8@135614|Xanthomonadales	135614|Xanthomonadales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_358276_1	517418.Ctha_1151	1.6e-17	88.6	COG0068@1|root,COG0068@2|Bacteria,1FDST@1090|Chlorobi	1090|Chlorobi	O	Belongs to the carbamoyltransferase HypF family	-	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_945427_1	1353537.TP2_08140	2.39e-07	53.5	COG2135@1|root,COG2135@2|Bacteria,1RER4@1224|Proteobacteria,2U0W2@28211|Alphaproteobacteria,2XMPQ@285107|Thioclava	28211|Alphaproteobacteria	S	Belongs to the SOS response-associated peptidase family	MA20_42060	-	-	-	-	-	-	-	-	-	-	-	SRAP
k59_945427_2	357808.RoseRS_1055	3.17e-42	149.0	COG0626@1|root,COG0626@2|Bacteria,2G5M2@200795|Chloroflexi,376G2@32061|Chloroflexia	32061|Chloroflexia	E	PFAM Cys Met metabolism pyridoxal-phosphate-dependent	-	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1118864_1	446471.Xcel_1503	3.02e-74	250.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2GN09@201174|Actinobacteria,4F3YP@85017|Promicromonosporaceae	201174|Actinobacteria	E	GXGXG motif	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_297609_1	1121875.KB907546_gene2203	2.95e-134	391.0	COG2367@1|root,COG2367@2|Bacteria,4NE3C@976|Bacteroidetes,1HZYJ@117743|Flavobacteriia	976|Bacteroidetes	V	beta-lactamase	per1	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
k59_1354113_1	765912.Thimo_0089	4.94e-125	366.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1WWZW@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_1236826_1	593907.Celgi_2663	1.59e-08	55.8	COG1477@1|root,COG1477@2|Bacteria,2GN6F@201174|Actinobacteria	201174|Actinobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_1236826_2	1035308.AQYY01000002_gene670	9.99e-25	99.8	COG3976@1|root,COG3976@2|Bacteria	2|Bacteria	S	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
k59_825520_1	1304888.ATWF01000001_gene1463	2.72e-13	67.0	COG0135@1|root,COG0135@2|Bacteria,2GFQH@200930|Deferribacteres	200930|Deferribacteres	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
k59_825520_2	1304885.AUEY01000012_gene1780	2.12e-55	176.0	COG1403@1|root,COG1403@2|Bacteria,1RGZQ@1224|Proteobacteria,42REM@68525|delta/epsilon subdivisions,2WNMG@28221|Deltaproteobacteria,2MJT7@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH
k59_766611_1	572477.Alvin_1647	1.6e-104	316.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1WX54@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_945434_1	298655.KI912266_gene4746	2.8e-27	114.0	28H5N@1|root,2Z7I8@2|Bacteria,2IC8E@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_180042_1	2340.JV46_22040	4.65e-83	261.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1J5GP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008883,GO:0009058,GO:0009064,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_1375,iECSF_1327.ECSF_1186,iUTI89_1310.UTI89_C1404	GlutR_N,GlutR_dimer,Shikimate_DH
k59_1061783_2	1123401.JHYQ01000027_gene3115	2.67e-33	120.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria,460CA@72273|Thiotrichales	72273|Thiotrichales	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_591796_1	446466.Cfla_3716	1.73e-10	67.0	COG0515@1|root,COG0515@2|Bacteria,2GM4A@201174|Actinobacteria,4F24D@85016|Cellulomonadaceae	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_1472426_1	395493.BegalDRAFT_3318	1.07e-203	589.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,4608B@72273|Thiotrichales	72273|Thiotrichales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_65777_2	396588.Tgr7_2494	3.82e-151	439.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_6332_1	518766.Rmar_1656	8.96e-102	324.0	COG0019@1|root,COG0527@1|root,COG0019@2|Bacteria,COG0527@2|Bacteria,4NFWR@976|Bacteroidetes,1FIKN@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Belongs to the Orn Lys Arg decarboxylase class-II family	-	-	2.7.2.4,4.1.1.20	ko:K00928,ko:K12526	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00451,R00480	RC00002,RC00043,RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_887592_1	1385935.N836_11090	5.53e-45	160.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_359258_1	545276.KB898735_gene1311	3.25e-94	281.0	COG1586@1|root,COG1586@2|Bacteria,1MXPT@1224|Proteobacteria,1RQSX@1236|Gammaproteobacteria,1WX2Z@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speD	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
k59_359258_2	754477.Q7C_1021	2e-86	261.0	COG2941@1|root,COG2941@2|Bacteria,1RAA1@1224|Proteobacteria,1RPMV@1236|Gammaproteobacteria,460NH@72273|Thiotrichales	72273|Thiotrichales	H	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol	coq7	-	-	ko:K06134	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00128	R04984,R08775	RC01254	ko00000,ko00001,ko00002,ko01000	-	-	-	COQ7
k59_359258_3	1182590.BN5_04220	2.66e-34	124.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria,1YFG1@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Bacterial transferase hexapeptide (six repeats)	yrdA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0009987,GO:0016043,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071840	-	-	-	-	-	-	-	-	-	-	Hexapep
k59_1119441_1	262543.Exig_0625	1.09e-110	324.0	COG0447@1|root,COG0447@2|Bacteria,1UHNU@1239|Firmicutes,4HAD0@91061|Bacilli	91061|Bacilli	H	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)	menB	-	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_650431_1	742727.HMPREF9447_02592	1.62e-56	198.0	COG2273@1|root,COG3533@1|root,COG2273@2|Bacteria,COG3533@2|Bacteria,4PNXU@976|Bacteroidetes,2FRD1@200643|Bacteroidia	976|Bacteroidetes	G	Ricin-type beta-trefoil lectin domain-like	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,RicinB_lectin_2
k59_180777_1	1304880.JAGB01000002_gene2397	4.38e-06	51.2	COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,248RY@186801|Clostridia	186801|Clostridia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_1237622_1	2340.JV46_16270	5.4e-50	175.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1J4IR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663	-	ko:K03688	-	-	-	-	ko00000	-	-	iYL1228.KPN_04331	ABC1
k59_1707068_1	1151118.KB895791_gene1899	2.52e-30	125.0	COG1361@1|root,COG1361@2|Bacteria,2I8F1@201174|Actinobacteria,1WBGC@1268|Micrococcaceae	201174|Actinobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
k59_359267_1	1121405.dsmv_0217	1.18e-43	153.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,42TGK@68525|delta/epsilon subdivisions,2WRBS@28221|Deltaproteobacteria,2MPUS@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
k59_1472449_1	316067.Geob_3838	3.39e-75	248.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria,43T3A@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_1119445_1	706587.Desti_1206	2.32e-133	392.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2MQXU@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_946502_1	1713.JOFV01000003_gene1659	9.18e-42	143.0	COG4803@1|root,COG4803@2|Bacteria,2IHYU@201174|Actinobacteria,4F1DQ@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1269)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
k59_1589296_1	96561.Dole_2107	1.47e-41	140.0	28NQ4@1|root,2ZBPU@2|Bacteria,1RCN1@1224|Proteobacteria,42QPC@68525|delta/epsilon subdivisions,2WMVS@28221|Deltaproteobacteria,2MJR9@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1589296_2	1121405.dsmv_1048	1.96e-30	115.0	COG1234@1|root,COG1234@2|Bacteria,1PPRD@1224|Proteobacteria,42N8A@68525|delta/epsilon subdivisions,2WKHD@28221|Deltaproteobacteria,2MIHV@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
k59_359279_2	593907.Celgi_0935	4.38e-29	106.0	COG1872@1|root,COG1872@2|Bacteria,2GQSC@201174|Actinobacteria	201174|Actinobacteria	EGP	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
k59_298372_1	671143.DAMO_2019	2.94e-28	112.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_298372_2	266835.14025561	2.37e-10	57.8	COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2UBSS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1472465_1	349102.Rsph17025_0799	1.76e-134	388.0	COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,2TVIR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	hmm pf01609	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_533072_1	768671.ThimaDRAFT_3799	2.77e-62	203.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1WWK3@135613|Chromatiales	135613|Chromatiales	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_1354820_1	1123251.ATWM01000004_gene1799	1e-101	313.0	2CC51@1|root,2Z7IU@2|Bacteria,2GM14@201174|Actinobacteria,4FIFS@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2397
k59_1413671_1	631362.Thi970DRAFT_03555	5.24e-40	144.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1WWER@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
k59_1413671_2	1236542.BALM01000003_gene630	8.01e-22	88.2	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,2QAP4@267890|Shewanellaceae	1236|Gammaproteobacteria	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019171,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iJN746.PP_1602	FabA
k59_240306_2	446466.Cfla_1903	8.77e-20	87.8	COG1793@1|root,COG1793@2|Bacteria,2IKE5@201174|Actinobacteria	201174|Actinobacteria	L	dna ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
k59_1707083_2	285535.JOEY01000060_gene8955	1.97e-06	51.2	COG0402@1|root,COG0402@2|Bacteria,2GM63@201174|Actinobacteria	201174|Actinobacteria	F	Pfam Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_359288_1	999141.GME_18113	8.67e-28	108.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1XH5S@135619|Oceanospirillales	135619|Oceanospirillales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_359288_2	435908.IDSA_01430	1.04e-60	202.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,2QG08@267893|Idiomarinaceae	1236|Gammaproteobacteria	U	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
k59_946523_2	446471.Xcel_1099	1.35e-19	80.5	COG1264@1|root,COG1264@2|Bacteria,2IQIB@201174|Actinobacteria,4F4SM@85017|Promicromonosporaceae	201174|Actinobacteria	G	phosphotransferase system, EIIB	-	-	2.7.1.193	ko:K02803	ko00520,ko02060,map00520,map02060	M00267	R05199	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7	-	-	PTS_EIIB
k59_1707088_1	398578.Daci_4005	8.9e-81	263.0	COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,2VJ9A@28216|Betaproteobacteria,4A9VA@80864|Comamonadaceae	28216|Betaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
k59_6406_1	2340.JV46_27220	8.65e-08	52.8	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RQBM@1236|Gammaproteobacteria,1J57D@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Aminotransferase class I and II	yfdZ	GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	iEcSMS35_1347.EcSMS35_2531,iSBO_1134.SBO_2405	Aminotran_1_2
k59_6406_2	637389.Acaty_c0335	2.01e-26	102.0	COG3737@1|root,COG3737@2|Bacteria,1N083@1224|Proteobacteria,1SD91@1236|Gammaproteobacteria,2ND4B@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
k59_1707091_1	1123392.AQWL01000007_gene873	7.44e-58	194.0	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,1MXK5@1224|Proteobacteria,2VKXP@28216|Betaproteobacteria,1KS3P@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
k59_1354830_1	292415.Tbd_1063	4.83e-32	114.0	2C3CF@1|root,32RRR@2|Bacteria,1MZUG@1224|Proteobacteria,2VV6N@28216|Betaproteobacteria,1KTC2@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Protein of unknown function (DUF3175)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3175
k59_180804_1	713586.KB900536_gene2364	8.88e-175	500.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1WXA3@135613|Chromatiales	135613|Chromatiales	U	General secretion pathway protein F	-	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
k59_180804_2	1452718.JBOY01000064_gene2580	2.33e-98	301.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_1061840_1	1179773.BN6_41110	2.13e-63	206.0	COG1215@1|root,COG1215@2|Bacteria,2GKKV@201174|Actinobacteria,4DYMN@85010|Pseudonocardiales	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2,GtrA
k59_1648641_1	1125863.JAFN01000001_gene2493	2.71e-36	140.0	COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,42NQM@68525|delta/epsilon subdivisions,2WK76@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	denitrification pathway	cbcY	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Ni_hydr_CYTB
k59_1413690_1	472759.Nhal_2283	2.31e-85	261.0	COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,1RP5A@1236|Gammaproteobacteria,1WY1K@135613|Chromatiales	135613|Chromatiales	P	TIGRFAM 3'(2'),5'-bisphosphate nucleotidase	-	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
k59_946543_1	555779.Dthio_PD2090	5.16e-109	339.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2M7U0@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1002105_1	243233.MCA0799	1.11e-90	272.0	COG0235@1|root,COG0235@2|Bacteria,1RE8T@1224|Proteobacteria,1S3UF@1236|Gammaproteobacteria,1XDKT@135618|Methylococcales	135618|Methylococcales	G	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P)	mtnB	-	4.2.1.109	ko:K08964	ko00270,ko01100,map00270,map01100	M00034	R07392	RC01939	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
k59_1002105_2	83406.HDN1F_13920	7.58e-12	66.2	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,1J5GM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_359312_1	439235.Dalk_3905	1.79e-09	63.9	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2WJKC@28221|Deltaproteobacteria,2MJ79@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_1178745_2	1123400.KB904749_gene816	6.57e-56	176.0	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,460ZB@72273|Thiotrichales	72273|Thiotrichales	C	Belongs to the glutaredoxin family. Monothiol subfamily	grxD	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
k59_946549_1	1146883.BLASA_0959	1.33e-49	171.0	COG4122@1|root,COG4122@2|Bacteria	2|Bacteria	E	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24,TylF
k59_887666_1	177437.HRM2_25410	6e-66	216.0	COG3385@1|root,COG5659@1|root,COG3385@2|Bacteria,COG5659@2|Bacteria,1R97Q@1224|Proteobacteria,42UH7@68525|delta/epsilon subdivisions,2X6SD@28221|Deltaproteobacteria,2MPID@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_6440_1	161934.XP_010675485.1	6.96e-23	100.0	COG2264@1|root,2QQTZ@2759|Eukaryota,37HS7@33090|Viridiplantae,3G84X@35493|Streptophyta	35493|Streptophyta	J	Ribosomal protein L11	-	-	-	-	-	-	-	-	-	-	-	-	PrmA
k59_826273_1	1286093.C266_06434	4.02e-50	172.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria,1K4KX@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_1826867_1	1031288.AXAA01000008_gene1236	1e-26	111.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,36FZW@31979|Clostridiaceae	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	aor	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS09915	AFOR_C,AFOR_N
k59_1648661_1	243090.RB12468	1.26e-10	67.0	28ISR@1|root,2Z8RV@2|Bacteria,2IXAN@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF4129)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
k59_946557_1	983917.RGE_29440	9.74e-48	171.0	COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,1RGKE@1224|Proteobacteria,2VKTE@28216|Betaproteobacteria,1KP06@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,PAS,PAS_3,PAS_4
k59_946560_1	335543.Sfum_3614	5.19e-51	179.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,43CFM@68525|delta/epsilon subdivisions,2X7QN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_122131_1	1279019.ARQK01000035_gene1554	1.26e-82	253.0	28I2K@1|root,2Z86N@2|Bacteria,1R1GA@1224|Proteobacteria,1RRPU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_122131_2	1190603.AJYD01000005_gene3913	6.28e-25	101.0	COG0483@1|root,COG0483@2|Bacteria,1NFR1@1224|Proteobacteria,1S31N@1236|Gammaproteobacteria,1Y0NG@135623|Vibrionales	135623|Vibrionales	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_1826881_1	211586.SO_3202	8.3e-63	197.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,1SYDF@1236|Gammaproteobacteria,2QAKC@267890|Shewanellaceae	1236|Gammaproteobacteria	NT	PFAM CheW domain protein	cheW	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
k59_1354851_3	742159.HMPREF0004_5331	1.54e-20	92.4	2CJ6B@1|root,32S9B@2|Bacteria,1N2I4@1224|Proteobacteria,2VV7N@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Thermostable hemolysin	-	-	-	-	-	-	-	-	-	-	-	-	T_hemolysin
k59_1002122_1	1298858.AUEL01000016_gene2602	8.09e-78	247.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2TRWK@28211|Alphaproteobacteria,43I12@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_479145_1	287.DR97_3483	2.46e-31	114.0	COG1522@1|root,COG1522@2|Bacteria,1RHD9@1224|Proteobacteria,1S6TQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional	nirD	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
k59_479145_2	1255043.TVNIR_1645	1.03e-53	174.0	COG1522@1|root,COG1522@2|Bacteria,1NVYY@1224|Proteobacteria,1S620@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	COG1522 Transcriptional regulators	nirL	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
k59_894454_1	671143.DAMO_0668	7.24e-34	132.0	COG0002@1|root,COG0002@2|Bacteria,2NNN5@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily	argC	GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.38	ko:K00145,ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00028,M00031,M00763,M00845	R03443,R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1782,iSSON_1240.SSON_4131,iYO844.BSU11190	Semialdhyde_dh,Semialdhyde_dhC
k59_1770045_1	290512.Paes_1895	7.6e-111	342.0	COG2989@1|root,COG2989@2|Bacteria,1FEJK@1090|Chlorobi	1090|Chlorobi	S	PFAM Peptidoglycan-binding domain 1 protein	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_1770045_2	435908.IDSA_11600	9.97e-61	189.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,1S3QK@1236|Gammaproteobacteria,2QG0Y@267893|Idiomarinaceae	1236|Gammaproteobacteria	J	Ribosomal protein L17	rplQ	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
k59_1770045_3	519989.ECTPHS_13183	1.9e-174	494.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1WWB2@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_1770045_4	34506.g5327	6.23e-65	222.0	COG0097@1|root,COG0098@1|root,COG0099@1|root,COG0100@1|root,COG0200@1|root,COG0522@1|root,KOG0408@2759|Eukaryota,KOG0846@2759|Eukaryota,KOG0877@2759|Eukaryota,KOG3254@2759|Eukaryota,KOG3301@2759|Eukaryota,KOG3311@2759|Eukaryota,3A0A4@33154|Opisthokonta,3BPCP@33208|Metazoa,3D14Y@33213|Bilateria,40D5S@6231|Nematoda,1KVYK@119089|Chromadorea,40TQD@6236|Rhabditida	33208|Metazoa	J	Ribosomal protein S11	MRPS11	GO:0000028,GO:0000313,GO:0000314,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0005761,GO:0005763,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006414,GO:0006415,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0019866,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0031090,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032543,GO:0032984,GO:0032991,GO:0033554,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0042769,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0050896,GO:0051606,GO:0051716,GO:0065003,GO:0070013,GO:0070125,GO:0070126,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0098798,GO:0140053,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
k59_1479570_1	313589.JNB_01470	4.96e-16	77.4	COG0723@1|root,COG0723@2|Bacteria,2GIX6@201174|Actinobacteria,4FE3Q@85021|Intrasporangiaceae	201174|Actinobacteria	C	Ubiquinol-cytochrome C reductase	qcrA	-	-	ko:K03890	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Rieske
k59_1479570_2	367299.JOEE01000004_gene1440	7.82e-83	251.0	COG2010@1|root,COG2010@2|Bacteria,2GKUB@201174|Actinobacteria,4FF7E@85021|Intrasporangiaceae	201174|Actinobacteria	C	Cystathionine beta-lyase	qcrC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03889	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrome_CBB3
k59_249691_1	622637.KE124774_gene1614	4.06e-63	205.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,2TYKR@28211|Alphaproteobacteria,36Z9G@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Nickel-dependent hydrogenase	-	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
k59_249691_2	595536.ADVE02000001_gene768	1.14e-10	61.2	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,2TVJC@28211|Alphaproteobacteria,36ZAX@31993|Methylocystaceae	28211|Alphaproteobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
k59_714320_2	1033730.CAHG01000012_gene1976	9.05e-26	105.0	COG1947@1|root,COG1947@2|Bacteria,2GKXD@201174|Actinobacteria,4DPS0@85009|Propionibacteriales	201174|Actinobacteria	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0040007,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_537973_1	1123023.JIAI01000002_gene5619	3.12e-20	95.1	COG2202@1|root,COG2203@1|root,COG4585@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4585@2|Bacteria,2I312@201174|Actinobacteria,4DZGK@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02480	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3,PAS_4
k59_249693_1	1506583.JQJY01000003_gene3260	6.28e-20	95.1	COG2234@1|root,COG2234@2|Bacteria,4NFZR@976|Bacteroidetes,1HXXH@117743|Flavobacteriia,2NTUJ@237|Flavobacterium	976|Bacteroidetes	U	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PD40,PDZ_2,Peptidase_M28
k59_1653861_1	565045.NOR51B_1314	6.09e-32	130.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_2160,iPC815.YPO2428	B3_4,B5,FDX-ACB,tRNA_bind
k59_1069002_2	1306406.ASHX01000001_gene4422	1.47e-26	108.0	COG1502@1|root,COG1502@2|Bacteria,2GM0P@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
k59_1123588_1	396588.Tgr7_1165	3.41e-19	86.3	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,1WX71@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_1123588_2	1049564.TevJSym_ba00140	4.86e-18	83.2	COG4589@1|root,COG4589@2|Bacteria,1R34Q@1224|Proteobacteria,1T63B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
k59_1833855_1	207559.Dde_1930	1.15e-167	473.0	28J6X@1|root,2Z92E@2|Bacteria,1R426@1224|Proteobacteria,42NPX@68525|delta/epsilon subdivisions,2WMA7@28221|Deltaproteobacteria,2MD13@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1711643_1	1229781.C272_03010	5.26e-08	50.4	2EHMB@1|root,33BD3@2|Bacteria,2HYRS@201174|Actinobacteria,4FAEZ@85019|Brevibacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_655694_2	349741.Amuc_0755	0.000431	43.9	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	ko:K02843,ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_tran_WbsX,Glyco_transf_9
k59_127359_1	1232437.KL662040_gene2120	4.48e-60	199.0	COG1641@1|root,COG1641@2|Bacteria,1MUKU@1224|Proteobacteria,42MHQ@68525|delta/epsilon subdivisions,2WJAC@28221|Deltaproteobacteria,2MHXQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
k59_831469_1	187272.Mlg_2254	2.88e-09	60.1	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1WX07@135613|Chromatiales	135613|Chromatiales	M	PFAM Cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_831469_2	1335757.SPICUR_01810	4.91e-41	144.0	COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,1RRT8@1236|Gammaproteobacteria,1WX90@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1365)	-	-	-	ko:K09701	-	-	-	-	ko00000	-	-	-	DUF1365
k59_596431_1	1150599.MPHLEI_15681	5.04e-29	110.0	COG0220@1|root,COG0220@2|Bacteria,2GJ8R@201174|Actinobacteria,234QK@1762|Mycobacteriaceae	201174|Actinobacteria	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
k59_596431_2	710421.Mycch_0186	2.55e-45	153.0	COG1432@1|root,COG1432@2|Bacteria,2GMV5@201174|Actinobacteria,234E5@1762|Mycobacteriaceae	201174|Actinobacteria	S	NYN domain	-	-	-	ko:K06860	-	-	-	-	ko00000	-	-	-	NYN
k59_1833875_1	1121937.AUHJ01000013_gene856	5.66e-122	368.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,46493@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	membrane GTPase involved in stress response	typA	GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_16141_1	446471.Xcel_1481	2.3e-58	189.0	COG0637@1|root,COG0637@2|Bacteria,2GJNG@201174|Actinobacteria,4F46E@85017|Promicromonosporaceae	201174|Actinobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_1244584_1	933262.AXAM01000030_gene805	7.17e-53	177.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,42TVX@68525|delta/epsilon subdivisions,2WQZU@28221|Deltaproteobacteria,2MNMU@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	Rod-binding,SLT
k59_186069_1	292415.Tbd_1306	3.71e-35	139.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,1KSQ2@119069|Hydrogenophilales	28216|Betaproteobacteria	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_655712_1	710696.Intca_2912	1.15e-73	241.0	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria,4FEZA@85021|Intrasporangiaceae	201174|Actinobacteria	G	Alpha-amylase domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_1359563_2	395493.BegalDRAFT_0112	4.5e-118	343.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,1RMMG@1236|Gammaproteobacteria,463Q9@72273|Thiotrichales	72273|Thiotrichales	S	PFAM Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1359563_3	1049564.TevJSym_as00540	0.000251	45.1	29QAQ@1|root,30B9W@2|Bacteria,1RGQ5@1224|Proteobacteria,1S5E4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1069050_1	203122.Sde_0805	2.09e-128	377.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,4649C@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Belongs to the GARS family	purD	GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01945,ko:K13713	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729	GARS_A,GARS_C,GARS_N
k59_714360_1	1304865.JAGF01000001_gene2307	1.88e-81	253.0	COG1609@1|root,COG1609@2|Bacteria,2GQER@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein LacI	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
k59_1359572_1	765914.ThisiDRAFT_0842	2.51e-34	125.0	COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria,1WXST@135613|Chromatiales	135613|Chromatiales	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	cpdA	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos
k59_1359572_2	572477.Alvin_1106	5.91e-79	245.0	COG1723@1|root,COG1723@2|Bacteria,1MWYM@1224|Proteobacteria,1S0B9@1236|Gammaproteobacteria,1WXSQ@135613|Chromatiales	135613|Chromatiales	S	Uncharacterised ACR, YagE family COG1723	-	-	-	-	-	-	-	-	-	-	-	-	DUF155
k59_771280_1	571166.KI421509_gene3325	1.58e-11	61.2	COG2010@1|root,COG2010@2|Bacteria,1RDSI@1224|Proteobacteria,2TWTZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Nitric oxide reductase	norC	-	-	ko:K02305	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002	3.D.4.10	-	-	Cytochrom_C
k59_127393_1	590998.Celf_1970	2.87e-69	235.0	COG1198@1|root,COG1198@2|Bacteria,2GKES@201174|Actinobacteria,4F24Z@85016|Cellulomonadaceae	201174|Actinobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
k59_1535541_1	472759.Nhal_3055	3.15e-88	276.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RNES@1236|Gammaproteobacteria,1X2HE@135613|Chromatiales	135613|Chromatiales	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_655734_1	105559.Nwat_1710	1.43e-08	56.6	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,1WWXY@135613|Chromatiales	135613|Chromatiales	S	Permease YjgP YjgQ	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_655734_2	1046714.AMRX01000007_gene2247	3.49e-29	120.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,465H9@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	permeases	lptF	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	iECED1_1282.ECED1_5114,iUMNK88_1353.UMNK88_5207	YjgP_YjgQ
k59_1593951_2	713586.KB900536_gene534	6.57e-126	393.0	COG0574@1|root,COG0574@2|Bacteria,1P35R@1224|Proteobacteria,1SWBY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
k59_771284_1	1189612.A33Q_2364	1.5e-36	128.0	COG0745@1|root,COG0745@2|Bacteria,4NP5C@976|Bacteroidetes,47Q8S@768503|Cytophagia	976|Bacteroidetes	KT	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_771284_2	926550.CLDAP_10060	1.98e-06	50.4	COG0591@1|root,COG5002@1|root,COG0591@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,HATPase_c,HisKA,Response_reg,SSF,SpoIIE
k59_16199_1	204773.HEAR2507	2.9e-54	175.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2VUIT@28216|Betaproteobacteria,476WJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
k59_16199_2	67332.FM21_36060	1.21e-21	96.3	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_72827_1	670307.HYPDE_31178	2.88e-12	66.6	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2TRYX@28211|Alphaproteobacteria,3N6XH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	membrane transporter protein	MA20_43555	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_72827_2	1267005.KB911263_gene1393	5.14e-21	91.3	COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,2TSRR@28211|Alphaproteobacteria,3N6A3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs	dusA	-	-	ko:K05539	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_479218_1	465817.ETA_20780	6.56e-41	141.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1RQ1J@1236|Gammaproteobacteria,3X4EF@551|Erwinia	1236|Gammaproteobacteria	K	response regulator	uvrY	GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007	-	ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_479218_2	1266914.ATUK01000012_gene194	2.78e-26	107.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1WW79@135613|Chromatiales	135613|Chromatiales	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
k59_366326_1	349521.HCH_05426	2.77e-79	251.0	COG4773@1|root,COG4773@2|Bacteria,1QWRF@1224|Proteobacteria,1RN9A@1236|Gammaproteobacteria,1XHTP@135619|Oceanospirillales	135619|Oceanospirillales	P	Receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1535553_1	1449347.JQLN01000002_gene2419	4.76e-73	235.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,2M05B@2063|Kitasatospora	201174|Actinobacteria	I	Carboxyl transferase domain	accD1	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1535553_2	366602.Caul_3157	1.07e-35	132.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,2KFW4@204458|Caulobacterales	204458|Caulobacterales	C	Dehydrogenase	-	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_953573_1	292415.Tbd_2655	2.36e-109	330.0	COG1009@1|root,COG1009@2|Bacteria,1MW9F@1224|Proteobacteria,2VIC8@28216|Betaproteobacteria,1KSTE@119069|Hydrogenophilales	119069|Hydrogenophilales	C	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_771293_1	999141.GME_03937	6.92e-68	214.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,1XJCZ@135619|Oceanospirillales	135619|Oceanospirillales	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
k59_771293_2	1397527.Q670_09095	2.12e-09	58.5	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1XH57@135619|Oceanospirillales	135619|Oceanospirillales	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_1123634_2	526227.Mesil_0570	6.49e-38	153.0	COG0507@1|root,COG1112@1|root,COG0507@2|Bacteria,COG1112@2|Bacteria	2|Bacteria	L	Superfamily I DNA and RNA helicases and helicase subunits	-	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_11,AAA_12,AAA_30,PDDEXK_1,UvrD_C_2,Viral_helicase1
k59_1770126_1	880072.Desac_1145	1.51e-84	276.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_1305769_1	2055.JNXA01000013_gene2835	2.43e-38	142.0	COG2197@1|root,COG2197@2|Bacteria,2GPKD@201174|Actinobacteria,4GBGV@85026|Gordoniaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, luxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE
k59_1069101_1	1229172.JQFA01000002_gene3128	1.42e-17	83.2	COG2403@1|root,COG2403@2|Bacteria,1G1FF@1117|Cyanobacteria,1HEMN@1150|Oscillatoriales	1117|Cyanobacteria	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	cobW
k59_1069101_2	706587.Desti_3042	4.43e-97	289.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,42PP3@68525|delta/epsilon subdivisions,2X227@28221|Deltaproteobacteria,2MQQ2@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_1069101_3	314278.NB231_10523	3.21e-19	85.9	COG1980@1|root,COG1980@2|Bacteria,1MXM7@1224|Proteobacteria,1SKUG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	-	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
k59_16244_1	911045.PSE_4528	8.15e-20	90.9	COG1024@1|root,COG1024@2|Bacteria,1MUD7@1224|Proteobacteria,2U230@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase	-	-	-	ko:K13816	ko02020,ko02024,map02020,map02024	-	-	-	ko00000,ko00001	-	-	-	ECH_1
k59_1244661_1	1463900.JOIX01000024_gene5678	2.07e-07	53.5	COG1273@1|root,COG1273@2|Bacteria,2GJMU@201174|Actinobacteria	201174|Actinobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050790,GO:0050896,GO:0051340,GO:0051351,GO:0051716,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
k59_1244661_2	47763.JNZA01000028_gene6135	6.95e-19	87.8	COG0025@1|root,COG0025@2|Bacteria,2I37Q@201174|Actinobacteria	201174|Actinobacteria	P	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1835069_1	439235.Dalk_2978	2.07e-104	306.0	COG1216@1|root,COG1216@2|Bacteria,1R50T@1224|Proteobacteria,42P74@68525|delta/epsilon subdivisions,2WK88@28221|Deltaproteobacteria,2MJIE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_23
k59_1360336_2	1116472.MGMO_41c00150	8.77e-74	224.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,1RQ7F@1236|Gammaproteobacteria,1XF8T@135618|Methylococcales	135618|Methylococcales	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_1654810_1	596320.NEIFL0001_0157	9.22e-16	83.6	COG2270@1|root,COG2270@2|Bacteria,1QUVA@1224|Proteobacteria,2WHTQ@28216|Betaproteobacteria,2KU4X@206351|Neisseriales	206351|Neisseriales	S	AmpG muropeptide MFS transporter K08218	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
k59_1070262_1	743721.Psesu_1225	9.25e-13	68.9	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria,1X4MV@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_1070262_2	204669.Acid345_4162	6.99e-12	64.7	COG1438@1|root,COG1438@2|Bacteria,3Y551@57723|Acidobacteria,2JJTA@204432|Acidobacteriia	204432|Acidobacteriia	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
k59_1306841_1	1254432.SCE1572_02520	6.95e-151	451.0	COG0827@1|root,COG0827@2|Bacteria,1MVG5@1224|Proteobacteria,42PJ2@68525|delta/epsilon subdivisions,2WPNM@28221|Deltaproteobacteria,2YVTI@29|Myxococcales	28221|Deltaproteobacteria	L	DNA modification methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I,TaqI_C
k59_1844027_1	713587.THITH_10355	3.17e-65	215.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM NADH-quinone oxidoreductase, chain G	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,NADH-G_4Fe-4S_3
k59_193378_1	471853.Bcav_2477	2.67e-17	81.3	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the peptidase M16 family	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1601103_1	77586.LPERR02G04860.1	3.4e-12	65.5	COG1012@1|root,KOG2730@1|root,KOG2451@2759|Eukaryota,KOG2730@2759|Eukaryota,37Q0D@33090|Viridiplantae,3G9A0@35493|Streptophyta,3KY7I@4447|Liliopsida,3ICJH@38820|Poales	35493|Streptophyta	C	Belongs to the aldehyde dehydrogenase family	-	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006105,GO:0006520,GO:0006536,GO:0006538,GO:0006540,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009448,GO:0009450,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0019752,GO:0031974,GO:0032787,GO:0036094,GO:0042133,GO:0042135,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.2.1.24	ko:K17761	ko00250,ko00650,ko01100,map00250,map00650,map01100	-	R00713	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_1601103_2	266835.14024661	7.65e-31	116.0	COG3369@1|root,COG3592@1|root,COG3369@2|Bacteria,COG3592@2|Bacteria,1RCN9@1224|Proteobacteria,2U878@28211|Alphaproteobacteria,43MTM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	CDGSH-type zinc finger. Function unknown.	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_19,Ferritin-like,zf-CDGSH
k59_427550_1	1049564.TevJSym_bb00310	2.95e-46	151.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	bigR	-	-	ko:K03892,ko:K07721,ko:K22042,ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
k59_134749_1	1120983.KB894574_gene1102	8.03e-65	223.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,1JPZW@119043|Rhodobiaceae	28211|Alphaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1012153_1	156889.Mmc1_2137	3.21e-98	297.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system large permease component	dctM	GO:0005575,GO:0016020,GO:0016021,GO:0031224,GO:0044425	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM,DctQ
k59_193392_1	1443665.JACA01000035_gene2263	2.01e-26	108.0	COG2355@1|root,COG2355@2|Bacteria,4NEBG@976|Bacteroidetes,1HXGJ@117743|Flavobacteriia,2YIUA@290174|Aquimarina	976|Bacteroidetes	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273,ko:K01274	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_C26,Peptidase_M19
k59_1426489_1	1163409.UUA_16438	1.62e-46	170.0	COG0591@1|root,COG0642@1|root,COG0784@1|root,COG0591@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,1X43U@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
k59_1129961_1	1095769.CAHF01000023_gene602	3.12e-12	68.6	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,472YU@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_1129961_2	398579.Spea_2001	2.32e-09	60.1	COG4313@1|root,COG4313@2|Bacteria,1MWCX@1224|Proteobacteria,1S4A1@1236|Gammaproteobacteria,2QAT2@267890|Shewanellaceae	1236|Gammaproteobacteria	C	COG4313 Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
k59_1844055_1	925409.KI911562_gene776	1.16e-55	198.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,4NDVA@976|Bacteroidetes,1IPFU@117747|Sphingobacteriia	976|Bacteroidetes	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1718787_1	1391646.AVSU01000015_gene2989	6.44e-112	333.0	COG1915@1|root,COG1915@2|Bacteria,1TT91@1239|Firmicutes,24A6C@186801|Clostridia,25SWN@186804|Peptostreptococcaceae	186801|Clostridia	S	PFAM LOR SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_376459_1	216595.PFLU_0480	2.48e-32	130.0	COG0515@1|root,COG3307@1|root,COG0515@2|Bacteria,COG3307@2|Bacteria,1NAGR@1224|Proteobacteria,1S0J2@1236|Gammaproteobacteria,1YQJW@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	KLMT	O-antigen ligase like membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Kdo,Wzy_C
k59_1012165_1	1267005.KB911263_gene1340	6.33e-79	262.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,2TTGI@28211|Alphaproteobacteria,3N9E8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Phosphate acyltransferases	aas	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase,MFS_1
k59_82893_1	313628.LNTAR_00270	4.61e-25	104.0	COG2907@1|root,COG2907@2|Bacteria	2|Bacteria	S	Flavin containing amine oxidoreductase	-	-	-	ko:K06954	-	-	-	-	ko00000	-	-	-	Amino_oxidase,NAD_binding_8
k59_82893_2	1123253.AUBD01000007_gene708	4.29e-51	170.0	COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,1RRT8@1236|Gammaproteobacteria,1X449@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1365)	-	-	-	ko:K09701	-	-	-	-	ko00000	-	-	-	DUF1365
k59_544979_1	926550.CLDAP_29120	2.71e-148	423.0	COG0667@1|root,COG0667@2|Bacteria,2G5V3@200795|Chloroflexi	200795|Chloroflexi	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1718791_1	994479.GL877878_gene3539	8.68e-35	127.0	COG2062@1|root,COG2062@2|Bacteria,2GJ0I@201174|Actinobacteria,4E5Q6@85010|Pseudonocardiales	201174|Actinobacteria	T	Phosphoglycerate mutase family	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
k59_1718791_2	1380370.JIBA01000015_gene305	3.51e-84	256.0	29VND@1|root,30H5P@2|Bacteria,2ICBQ@201174|Actinobacteria,4FHGV@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_722306_1	1043493.BBLU01000018_gene1535	9.66e-84	261.0	COG4320@1|root,COG4320@2|Bacteria,2GKEK@201174|Actinobacteria	201174|Actinobacteria	K	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
k59_1367705_1	1122604.JONR01000003_gene1519	1.08e-103	311.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPGB@1236|Gammaproteobacteria,1X4QM@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_135533_2	335543.Sfum_3631	8.1e-39	132.0	COG2052@1|root,COG2052@2|Bacteria,1N0KP@1224|Proteobacteria,42TSK@68525|delta/epsilon subdivisions,2WQHH@28221|Deltaproteobacteria,2MS3J@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Belongs to the UPF0296 family	-	-	-	ko:K09777	-	-	-	-	ko00000	-	-	-	DUF370
k59_964764_4	1122951.ATUE01000005_gene1750	0.00036	41.6	COG1595@1|root,COG1595@2|Bacteria,1R9WC@1224|Proteobacteria,1SA30@1236|Gammaproteobacteria,3NJEX@468|Moraxellaceae	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE1	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1012879_1	1469245.JFBG01000023_gene1275	9.84e-82	256.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1S1KY@1236|Gammaproteobacteria,1X28H@135613|Chromatiales	135613|Chromatiales	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_1012879_2	713586.KB900536_gene2820	1.72e-45	158.0	COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,1SEJ8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_545705_1	1713.JOFV01000001_gene1941	4.36e-31	126.0	COG0801@1|root,COG1539@1|root,COG0801@2|Bacteria,COG1539@2|Bacteria,2H3G6@201174|Actinobacteria,4F0X7@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
k59_261961_1	859653.HIMB5_00008580	4.24e-41	146.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,4BPA4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	dctM1	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_261961_2	765913.ThidrDRAFT_0849	0.000358	44.7	COG0589@1|root,COG0589@2|Bacteria,1NB6E@1224|Proteobacteria,1SEN6@1236|Gammaproteobacteria,1WZ7A@135613|Chromatiales	135613|Chromatiales	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_194169_1	443255.SCLAV_3221	4.13e-68	225.0	COG5002@1|root,COG5002@2|Bacteria,2GJY7@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	senX3	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:1901564	2.7.13.3	ko:K07768	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_964770_1	1049564.TevJSym_aa01890	4.83e-108	327.0	COG0699@1|root,COG0699@2|Bacteria,1MV59@1224|Proteobacteria,1RYGW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_1601865_1	1163408.UU9_00844	1.19e-13	75.1	COG4773@1|root,COG4773@2|Bacteria,1NZCG@1224|Proteobacteria,1T1NA@1236|Gammaproteobacteria,1X3J2@135614|Xanthomonadales	135614|Xanthomonadales	P	receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1845187_1	95619.PM1_0218220	2.32e-16	78.2	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_1845187_2	572477.Alvin_0952	1.09e-41	145.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,1WWA0@135613|Chromatiales	135613|Chromatiales	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
k59_663826_1	1313172.YM304_07270	1.5e-66	223.0	COG1835@1|root,COG1835@2|Bacteria,2GKI5@201174|Actinobacteria,4CNC6@84992|Acidimicrobiia	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_194175_1	471853.Bcav_1929	2.6e-81	265.0	COG0439@1|root,COG0454@1|root,COG1042@1|root,COG0439@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria	201174|Actinobacteria	C	CoA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_905825_1	1163617.SCD_n02012	7.51e-82	254.0	COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,2VNGV@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_905825_2	1211115.ALIQ01000030_gene2226	6.31e-28	114.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,3NAA1@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_1081299_1	1122603.ATVI01000005_gene3042	7.79e-07	54.3	COG0668@1|root,COG0668@2|Bacteria,1N4UN@1224|Proteobacteria,1T9TX@1236|Gammaproteobacteria,1XBUR@135614|Xanthomonadales	135614|Xanthomonadales	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
k59_261982_1	488538.SAR116_2094	3.26e-40	152.0	COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,2U1SX@28211|Alphaproteobacteria,4BPZ2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	N	ABC-type uncharacterized transport system	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_transp_aux
k59_1490138_1	1304865.JAGF01000001_gene1532	9.71e-82	250.0	COG4097@1|root,COG4097@2|Bacteria	2|Bacteria	P	nitric oxide dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Fer2,Ferric_reduct,NAD_binding_1
k59_1081308_1	1089552.KI911559_gene2871	1.83e-60	202.0	COG2710@1|root,COG2710@2|Bacteria,1MUGI@1224|Proteobacteria,2TU7U@28211|Alphaproteobacteria,2JQIN@204441|Rhodospirillales	204441|Rhodospirillales	C	Nitrogenase component 1 type Oxidoreductase	bchY	-	1.3.7.14,1.3.7.15	ko:K11334	ko00860,ko01110,map00860,map01110	-	R09053,R09060	RC01008	ko00000,ko00001,ko01000	-	-	-	Oxidored_nitro
k59_377601_1	1517416.IDAT_09840	2.54e-24	95.9	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S8RS@1236|Gammaproteobacteria,2QG3Q@267893|Idiomarinaceae	1236|Gammaproteobacteria	U	Biopolymer	tolR	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032153,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
k59_377601_2	1268239.PALB_31880	9.71e-36	127.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,2Q0T1@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	U	COG0811 Biopolymer transport proteins	tolQ	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0017038,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0033036,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
k59_1081309_1	1007105.PT7_2187	3.46e-41	146.0	COG1638@1|root,COG1638@2|Bacteria,1P3MK@1224|Proteobacteria	1224|Proteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	ko:K11688	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
k59_722323_2	998674.ATTE01000001_gene4168	2.42e-134	399.0	COG1196@1|root,COG1196@2|Bacteria,1MVMQ@1224|Proteobacteria,1S2MH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_261997_1	1185653.A1A1_00735	2.11e-09	63.5	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli,26ECD@186818|Planococcaceae	91061|Bacilli	E	substrate-binding protein	dppA_1	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_28096_1	1121022.ABENE_13040	7.57e-35	136.0	COG5659@1|root,COG5659@2|Bacteria,1MWAV@1224|Proteobacteria,2U2Q3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_311151_1	1122604.JONR01000010_gene3999	2.64e-108	337.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1X4NS@135614|Xanthomonadales	135614|Xanthomonadales	M	Lytic murein transglycosylase	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
k59_964802_1	1121933.AUHH01000042_gene3588	1.57e-09	57.4	COG3576@1|root,COG3576@2|Bacteria,2H4XW@201174|Actinobacteria	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
k59_964802_3	1121374.KB891591_gene3526	1.86e-13	66.6	COG2261@1|root,COG2261@2|Bacteria,1N72Y@1224|Proteobacteria,1SCD4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM Transglycosylase-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
k59_428402_1	545276.KB898727_gene384	1.89e-44	164.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1WWGW@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM ATP-dependent helicase HrpA	-	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_1543622_1	768671.ThimaDRAFT_2966	2.07e-93	295.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales	135613|Chromatiales	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_1081330_1	472759.Nhal_0548	6.9e-57	192.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales	135613|Chromatiales	S	modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_1543623_2	876044.IMCC3088_2038	5.98e-33	117.0	COG1320@1|root,COG1320@2|Bacteria	2|Bacteria	P	monovalent cation:proton antiporter activity	mnhG	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_377624_1	768671.ThimaDRAFT_0181	2.27e-07	52.8	COG2608@1|root,COG2608@2|Bacteria	2|Bacteria	P	mercury ion transmembrane transporter activity	-	-	3.6.3.4	ko:K01533,ko:K07213	ko04978,map04978	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	HMA
k59_377624_2	1123070.KB899251_gene665	6.85e-16	78.6	COG0805@1|root,COG0805@2|Bacteria,46T26@74201|Verrucomicrobia,2ITNJ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_663851_1	590998.Celf_3098	1.28e-109	359.0	COG1112@1|root,COG1112@2|Bacteria,2GKJW@201174|Actinobacteria,4F0UY@85016|Cellulomonadaceae	201174|Actinobacteria	L	Superfamily I DNA and RNA helicases and helicase subunits	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DUF4011
k59_964822_1	278957.ABEA03000072_gene3020	1.51e-08	61.6	COG2202@1|root,COG2208@1|root,COG2202@2|Bacteria,COG2208@2|Bacteria,46SWK@74201|Verrucomicrobia,3K87J@414999|Opitutae	414999|Opitutae	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,PAS_3,SpoIIE
k59_1543627_1	765913.ThidrDRAFT_1378	7.22e-140	418.0	COG1404@1|root,COG4287@1|root,COG1404@2|Bacteria,COG4287@2|Bacteria,1NP5V@1224|Proteobacteria,1RS87@1236|Gammaproteobacteria,1X0VB@135613|Chromatiales	135613|Chromatiales	O	PhoPQ-activated pathogenicity-related protein	-	-	-	-	-	-	-	-	-	-	-	-	PhoPQ_related
k59_663852_1	1323361.JPOC01000002_gene4473	6.12e-43	150.0	COG2227@1|root,COG2227@2|Bacteria,2IIRY@201174|Actinobacteria,4FYEA@85025|Nocardiaceae	201174|Actinobacteria	H	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
k59_663852_3	593907.Celgi_0059	1.11e-30	112.0	COG0607@1|root,COG0607@2|Bacteria,2HFZ1@201174|Actinobacteria,4F2X6@85016|Cellulomonadaceae	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1601907_1	156889.Mmc1_2108	1.17e-58	193.0	COG2006@1|root,COG2006@2|Bacteria,1QMGX@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
k59_839643_1	1307759.JOMJ01000003_gene808	1.68e-53	184.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,42N91@68525|delta/epsilon subdivisions,2WIMM@28221|Deltaproteobacteria,2M8Z2@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
k59_777953_1	522306.CAP2UW1_2826	3.53e-97	303.0	COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VH3T@28216|Betaproteobacteria,1KQAC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	SNARE associated Golgi protein	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,SNARE_assoc
k59_28136_1	983917.RGE_31920	6.59e-73	224.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2VIJ2@28216|Betaproteobacteria,1KJRV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	cytochrome C oxidase	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
k59_1012932_2	316407.85674377	1.36e-19	85.9	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,1S5YQ@1236|Gammaproteobacteria,3XPJ1@561|Escherichia	1236|Gammaproteobacteria	J	Rescues stalled ribosomes. Can hydrolyze peptidyl-tRNA on ribosomes stalled by both non-stop mRNAs and mRNAs that contain rare codon clusters or ribosomes stalled in the middle of mRNA. First identified as a complementary ribosome rescue system when the stalled ribosome cannot be rescued by the SsrA(tmRNA)-SmpB quality control system or the alternative ribosome-rescue factor A (arfA)	yaeJ	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
k59_1012932_3	1415779.JOMH01000001_gene2103	1.7e-09	58.9	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,1X4U5@135614|Xanthomonadales	135614|Xanthomonadales	S	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	MMPL
k59_1255390_1	1189612.A33Q_3727	2.8e-55	192.0	COG0339@1|root,COG0339@2|Bacteria,4NFYA@976|Bacteroidetes,47KDS@768503|Cytophagia	976|Bacteroidetes	E	PFAM Peptidase family M3	-	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_1845262_1	1282876.BAOK01000001_gene3452	2.16e-135	406.0	COG0028@1|root,COG2146@1|root,COG0028@2|Bacteria,COG2146@2|Bacteria,1MWKP@1224|Proteobacteria,2TQK6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	poxB	-	1.2.3.3,1.2.5.1	ko:K00156,ko:K00158	ko00620,ko01100,map00620,map01100	-	R00207,R03145	RC00860,RC02745	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1719677_1	391603.FBALC1_06438	1.79e-53	189.0	COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1HYRS@117743|Flavobacteriia	976|Bacteroidetes	M	Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_377655_1	323848.Nmul_A0535	1.17e-31	126.0	COG3319@1|root,COG3319@2|Bacteria,1N402@1224|Proteobacteria,2W4G7@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1255401_1	634500.EbC_02760	8.52e-81	255.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,3X4RF@551|Erwinia	1236|Gammaproteobacteria	F	Glycinamide ribonucleotide synthetase	purD	GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01945,ko:K13713	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729	GARS_A,GARS_C,GARS_N
k59_1317080_1	29486.NJ56_02180	3e-43	142.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,41GAB@629|Yersinia	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
k59_1497426_1	1123278.KB893556_gene3798	2.73e-40	158.0	COG2304@1|root,COG2304@2|Bacteria,4P9PS@976|Bacteroidetes,47WEN@768503|Cytophagia	976|Bacteroidetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	Tyrosinase,VWA_2
k59_1668396_1	95619.PM1_0225450	1.61e-83	268.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0488 ATPase components of ABC transporters with duplicated ATPase domains	uup	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_93750_1	82654.Pse7367_2569	7.27e-73	237.0	COG2208@1|root,COG2208@2|Bacteria,1G3MK@1117|Cyanobacteria,1H9X2@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Sporulation stage II, protein E C-terminal	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF,GAF_2,HAMP,HisKA,Response_reg,SpoIIE
k59_317431_1	981384.AEYW01000001_gene1535	1.02e-48	166.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,4NCXC@97050|Ruegeria	28211|Alphaproteobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_1607517_1	765914.ThisiDRAFT_1725	8.87e-140	406.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1WW77@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
k59_1018082_1	765911.Thivi_2767	8.03e-26	107.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1WWA8@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_1018082_2	1397527.Q670_03445	1.06e-13	70.5	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XH4Q@135619|Oceanospirillales	135619|Oceanospirillales	V	efflux pump	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_434439_1	596151.DesfrDRAFT_1613	5.37e-34	135.0	COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,1RCHY@1224|Proteobacteria,42R1G@68525|delta/epsilon subdivisions,2WMR7@28221|Deltaproteobacteria,2M83U@213115|Desulfovibrionales	28221|Deltaproteobacteria	KT	SMART protein phosphatase 2C domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE
k59_1497443_1	886293.Sinac_5242	6.32e-39	135.0	2C3PP@1|root,2Z954@2|Bacteria,2J2AE@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_38268_1	96561.Dole_0632	2.13e-58	204.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,2MI09@213118|Desulfobacterales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_728198_1	1454010.JEOE01000048_gene1472	1.77e-40	137.0	COG1320@1|root,COG1320@2|Bacteria,2IQXD@201174|Actinobacteria,4F1FT@85016|Cellulomonadaceae	201174|Actinobacteria	P	TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit	mrpG	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_728198_2	1454010.JEOE01000048_gene1471	2.34e-11	64.7	COG2212@1|root,COG2212@2|Bacteria,2GRIE@201174|Actinobacteria,4F1FD@85016|Cellulomonadaceae	201174|Actinobacteria	P	Multiple resistance and pH regulation protein F (MrpF / PhaF)	mrpF	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
k59_141469_1	1049564.TevJSym_bh00100	2.35e-70	224.0	COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1J59K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	TPR_1,TPR_16,TPR_2,VWA_2
k59_974622_1	998088.B565_0934	1.12e-61	196.0	COG3063@1|root,COG3063@2|Bacteria,1RD9T@1224|Proteobacteria,1S3R3@1236|Gammaproteobacteria,1Y540@135624|Aeromonadales	135624|Aeromonadales	NU	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_8
k59_387270_1	56780.SYN_00551	1.24e-63	214.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,2MQ74@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Penicillin-binding protein, dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928	PBP_dimer,Transpeptidase
k59_271658_1	472759.Nhal_3711	2.26e-55	184.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1WW00@135613|Chromatiales	135613|Chromatiales	H	Belongs to the ALAD family	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_271658_2	998088.B565_2045	2.07e-25	102.0	COG1595@1|root,COG1595@2|Bacteria,1R9ZN@1224|Proteobacteria,1S27W@1236|Gammaproteobacteria,1Y5NI@135624|Aeromonadales	135624|Aeromonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1725889_1	864051.BurJ1DRAFT_4556	8.58e-90	290.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KJ2M@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	AcrB/AcrD/AcrF family	acrD	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_915571_2	391625.PPSIR1_06031	5.63e-24	103.0	COG4188@1|root,COG4188@2|Bacteria,1MW2N@1224|Proteobacteria,42W4F@68525|delta/epsilon subdivisions,2WR90@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,DLH,PAF-AH_p_II
k59_38277_1	1500890.JQNL01000001_gene750	2.73e-73	234.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1X3DQ@135614|Xanthomonadales	135614|Xanthomonadales	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI
k59_38277_2	757424.Hsero_0358	5.45e-13	69.7	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2WGFR@28216|Betaproteobacteria,473XN@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Transporter associated domain	corB	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1497454_1	1168065.DOK_15204	1.43e-40	149.0	COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,1RR1C@1236|Gammaproteobacteria,1J5C4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1373484_1	1286106.MPL1_09260	6.17e-44	165.0	COG2199@1|root,COG2200@1|root,COG2204@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG2204@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,460I2@72273|Thiotrichales	72273|Thiotrichales	T	diguanylate cyclase (GGDEF) domain	-	-	-	ko:K21025	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	EAL,GGDEF,PAS_9
k59_1607534_1	1267534.KB906754_gene3193	1.01e-07	59.7	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	ytcC	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	ko:K06338,ko:K16695	-	-	-	-	ko00000,ko02000	2.A.66.2.7	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
k59_434463_1	207954.MED92_10219	1.11e-14	76.3	COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,1T214@1236|Gammaproteobacteria,1XI74@135619|Oceanospirillales	135619|Oceanospirillales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
k59_669715_2	1304865.JAGF01000001_gene3831	2.68e-48	167.0	COG0758@1|root,COG0758@2|Bacteria,2GKDA@201174|Actinobacteria,4F0K2@85016|Cellulomonadaceae	201174|Actinobacteria	LU	DNA recombination-mediator protein A	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_1783845_1	1123072.AUDH01000003_gene838	2.09e-44	156.0	COG0613@1|root,COG0613@2|Bacteria,1PBDI@1224|Proteobacteria,2U1HY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PHP family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_200045_2	886293.Sinac_6188	1.79e-50	176.0	COG0129@1|root,COG0129@2|Bacteria,2IWXV@203682|Planctomycetes	203682|Planctomycetes	H	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_1668433_1	1380393.JHVP01000005_gene3685	1.04e-18	85.1	2CK3K@1|root,32SBH@2|Bacteria,2IQJH@201174|Actinobacteria,4EW97@85013|Frankiales	201174|Actinobacteria	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
k59_271694_1	1049564.TevJSym_aa01580	3.42e-54	187.0	COG1216@1|root,COG1216@2|Bacteria,1MX5Z@1224|Proteobacteria,1RMDY@1236|Gammaproteobacteria,1J53J@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2
k59_974676_1	1454010.JEOE01000002_gene396	1.42e-38	144.0	COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,4F1NX@85016|Cellulomonadaceae	201174|Actinobacteria	L	SMART DNA gyrase topoisomerase IV subunit A	gyrA2	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_551894_1	543913.D521_1713	3.19e-32	124.0	COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,2VJ3T@28216|Betaproteobacteria,1KPYJ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	GM	NAD dependent epimerase/dehydratase family	yeeZ	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10,RmlD_sub_bind,TrkA_N
k59_93834_1	1304876.AZVC01000002_gene965	5.82e-52	174.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,1W9DK@1268|Micrococcaceae	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
k59_93834_2	1194165.CAJF01000009_gene814	1.66e-27	108.0	COG0451@1|root,COG0451@2|Bacteria,2I2UT@201174|Actinobacteria,4FTRG@85023|Microbacteriaceae	201174|Actinobacteria	M	Polysaccharide biosynthesis protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_610522_1	926561.KB900623_gene1017	3.4e-16	83.6	COG1033@1|root,COG1033@2|Bacteria,1UVYF@1239|Firmicutes,25J6F@186801|Clostridia,3WBJS@53433|Halanaerobiales	186801|Clostridia	S	Sterol-sensing domain of SREBP cleavage-activation	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_387331_1	1129794.C427_2477	1.66e-74	236.0	COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,1SZQR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_1725918_1	626887.J057_18040	7.71e-12	65.1	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,4655Y@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iEC55989_1330.EC55989_0819,iECO111_1330.ECO111_0837,iECO26_1355.ECO26_0902,iSDY_1059.SDY_0830	Aminotran_1_2
k59_1725918_2	768671.ThimaDRAFT_3269	3.26e-84	259.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,1WWXZ@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
k59_38319_1	1123261.AXDW01000024_gene2057	1.84e-54	188.0	COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1RNNQ@1236|Gammaproteobacteria,1X4D8@135614|Xanthomonadales	135614|Xanthomonadales	S	aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_141511_1	28444.JODQ01000001_gene2130	2.05e-27	115.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4EGD4@85012|Streptosporangiales	201174|Actinobacteria	L	Bacterial DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1607559_2	765912.Thimo_3262	3.54e-87	265.0	COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria,1WVWS@135613|Chromatiales	135613|Chromatiales	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	apaH	-	3.6.1.41	ko:K01525	ko00230,map00230	-	R00125	RC00002	ko00000,ko00001,ko01000	-	-	-	Metallophos
k59_974694_2	1163617.SCD_n00315	3.7e-65	216.0	COG3746@1|root,COG3746@2|Bacteria,1MY3M@1224|Proteobacteria,2VIIP@28216|Betaproteobacteria	28216|Betaproteobacteria	P	phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_271715_1	1122604.JONR01000050_gene3127	3.81e-79	243.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,1X31A@135614|Xanthomonadales	135614|Xanthomonadales	S	abc transporter atp-binding protein	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
k59_271715_2	95619.PM1_0206370	1.02e-11	65.5	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_1783868_1	546271.Selsp_1473	3.03e-44	150.0	COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,4H3Z7@909932|Negativicutes	909932|Negativicutes	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_1783868_2	869213.JCM21142_31262	6.83e-12	62.0	COG0256@1|root,COG0256@2|Bacteria,4NQAS@976|Bacteroidetes,47RC9@768503|Cytophagia	976|Bacteroidetes	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
k59_1497499_1	1122604.JONR01000007_gene2929	1.34e-92	283.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,1X3P8@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	yfcY	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_915657_1	1123518.ARWI01000001_gene1948	1.56e-41	150.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,4601B@72273|Thiotrichales	72273|Thiotrichales	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_915657_2	1033802.SSPSH_000611	0.000118	45.1	COG3568@1|root,COG3568@2|Bacteria,1RBWV@1224|Proteobacteria,1RYBE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_434497_1	391037.Sare_0141	5.31e-28	114.0	COG2271@1|root,COG2271@2|Bacteria,2HB3P@201174|Actinobacteria,4DCV1@85008|Micromonosporales	201174|Actinobacteria	G	PFAM major facilitator superfamily MFS_1	-	GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0015562,GO:0022857,GO:0042221,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
k59_1198571_1	762948.HMPREF0733_10276	3.85e-69	214.0	COG0099@1|root,COG0099@2|Bacteria,2IHPN@201174|Actinobacteria,1W980@1268|Micrococcaceae	201174|Actinobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_1497511_1	906968.Trebr_2577	0.000107	49.3	COG0477@1|root,COG0477@2|Bacteria,2J6CF@203691|Spirochaetes	203691|Spirochaetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	ko:K08217	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.22	-	-	MFS_1,MFS_3
k59_1373525_1	1160137.KB907307_gene2574	5.63e-57	194.0	COG1216@1|root,COG1216@2|Bacteria,2I7RE@201174|Actinobacteria,4G9VQ@85025|Nocardiaceae	201174|Actinobacteria	S	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1198574_1	1269813.ATUL01000008_gene1544	1.03e-23	98.2	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1WXB7@135613|Chromatiales	135613|Chromatiales	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_1198574_2	1122604.JONR01000014_gene254	1.37e-09	60.5	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1X6HN@135614|Xanthomonadales	135614|Xanthomonadales	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_434514_1	367299.JOEE01000008_gene458	1.75e-87	273.0	COG1960@1|root,COG1960@2|Bacteria,2GJHM@201174|Actinobacteria,4FEUI@85021|Intrasporangiaceae	201174|Actinobacteria	I	acyl-CoA dehydrogenase	aidB	-	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
k59_1199309_1	1236541.BALL01000062_gene4662	9.23e-57	179.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,1S452@1236|Gammaproteobacteria,2QBN5@267890|Shewanellaceae	1236|Gammaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010608,GO:0015935,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031329,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043487,GO:0043488,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903311,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
k59_1199309_2	1244869.H261_06019	3.05e-05	45.8	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,2TV09@28211|Alphaproteobacteria,2JSD2@204441|Rhodospirillales	204441|Rhodospirillales	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_976117_2	1304865.JAGF01000001_gene1909	2.05e-72	224.0	COG1595@1|root,COG1595@2|Bacteria,2GJUI@201174|Actinobacteria,4F2K2@85016|Cellulomonadaceae	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
k59_388738_2	91464.S7335_4243	3.48e-46	168.0	COG1262@1|root,COG1262@2|Bacteria,1G0FF@1117|Cyanobacteria,1GYJP@1129|Synechococcus	1117|Cyanobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
k59_1608300_1	429009.Adeg_1885	4.96e-23	97.8	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,42FJG@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
k59_611355_1	1304874.JAFY01000007_gene1728	1.18e-05	53.1	COG5421@1|root,COG5421@2|Bacteria,3TAD9@508458|Synergistetes	508458|Synergistetes	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_494059_2	1453501.JELR01000005_gene1704	1.45e-14	75.5	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria,465FU@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon	birA	GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
k59_388750_1	83406.HDN1F_01050	9.47e-62	190.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,1S5WR@1236|Gammaproteobacteria,1J67I@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the thioredoxin family	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	iECW_1372.ECW_m4079,iECs_1301.ECs4714,iEKO11_1354.EKO11_4576,iG2583_1286.G2583_4574,iSBO_1134.SBO_3791,iSDY_1059.SDY_3968,iSF_1195.SF3854,iSSON_1240.SSON_3952,iS_1188.S3905,iWFL_1372.ECW_m4079,iZ_1308.Z5291	Thioredoxin
k59_1199332_1	1229172.JQFA01000004_gene422	4.48e-37	140.0	COG1132@1|root,COG1132@2|Bacteria,1G02Q@1117|Cyanobacteria,1H8KQ@1150|Oscillatoriales	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_729046_1	535289.Dtpsy_1547	9.13e-20	87.8	COG0748@1|root,COG0748@2|Bacteria,1PSK9@1224|Proteobacteria,2VUY6@28216|Betaproteobacteria,4AF8P@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM pyridoxamine 5'-phosphate oxidase-related, FMN-binding	-	-	-	ko:K07226	-	-	-	-	ko00000	-	-	-	Putative_PNPOx,Pyrid_oxidase_2
k59_1434398_1	765913.ThidrDRAFT_0055	3.03e-137	400.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1WWJ0@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_1498273_1	1096930.L284_09170	2.2e-71	224.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,2K43N@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1498273_2	420324.KI911947_gene5647	1.15e-13	66.2	COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,1JVU8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_1137244_1	590409.Dd586_4064	6.87e-08	60.8	COG0697@1|root,COG0697@2|Bacteria,1MVKG@1224|Proteobacteria,1RM8T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EG	of the drug metabolite transporter (DMT) superfamily	eamA	GO:0000101,GO:0003333,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015562,GO:0015711,GO:0015804,GO:0015849,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0032973,GO:0033228,GO:0034220,GO:0042883,GO:0044425,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:0140115,GO:1903712,GO:1903825,GO:1905039	-	ko:K03298,ko:K15268	-	-	-	-	ko00000,ko02000	2.A.7.3,2.A.7.3.2	-	iECIAI39_1322.ECIAI39_1835	EamA
k59_1726745_1	322710.Avin_35020	2.03e-71	230.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,1T1MS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Hemolysins and related proteins containing CBS domains	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_976164_1	446466.Cfla_1515	3.79e-07	57.8	COG4932@1|root,COG5297@1|root,COG4932@2|Bacteria,COG5297@2|Bacteria,2GMQN@201174|Actinobacteria,4F1MZ@85016|Cellulomonadaceae	201174|Actinobacteria	G	PFAM glycoside hydrolase family 9	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_2,CBM_4_9,CelD_N,Glyco_hydro_9,I-set
k59_1550173_1	1049564.TevJSym_an00080	7.41e-73	236.0	COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J4XJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0471 Di- and tricarboxylate transporters	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_1498274_1	1304865.JAGF01000001_gene2163	2.22e-125	362.0	COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria	201174|Actinobacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_1089762_1	349102.Rsph17025_1430	5.11e-273	758.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2U9E7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_435305_1	665029.EAMY_0089	9.77e-12	70.1	COG0859@1|root,COG0859@2|Bacteria,1R4IT@1224|Proteobacteria,1RQF5@1236|Gammaproteobacteria,3X5ZR@551|Erwinia	1236|Gammaproteobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
k59_675125_2	2340.JV46_26720	6.76e-158	458.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,1JARP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Nickel-dependent hydrogenase	hydB	-	1.12.5.1,1.12.99.6	ko:K05922,ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_1673709_1	69042.WH5701_09920	9.09e-168	478.0	COG3335@1|root,COG3335@2|Bacteria,1G60T@1117|Cyanobacteria,1H3RV@1129|Synechococcus	1117|Cyanobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23
k59_1612785_1	396588.Tgr7_1035	2.52e-99	304.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1WXCW@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
k59_102770_1	367299.JOEE01000001_gene2162	1.71e-204	603.0	COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria,4FFYE@85021|Intrasporangiaceae	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1378713_1	590998.Celf_3212	9.38e-106	319.0	COG1819@1|root,COG1819@2|Bacteria	2|Bacteria	CG	transferase activity, transferring hexosyl groups	alg2	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,UDPGT
k59_498538_1	266265.Bxe_B1231	1.18e-54	186.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,1K1DV@119060|Burkholderiaceae	28216|Betaproteobacteria	MU	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
k59_439801_1	1379698.RBG1_1C00001G0048	7.04e-40	140.0	COG1941@1|root,COG1941@2|Bacteria,2NQP6@2323|unclassified Bacteria	2|Bacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Fe_hyd_lg_C,Fer4,FlpD,Oxidored_q6
k59_439801_2	880073.Calab_3045	2.92e-19	83.6	COG1908@1|root,COG1908@2|Bacteria,2NPFI@2323|unclassified Bacteria	2|Bacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	bamF	-	1.8.98.5,1.8.98.6	ko:K14127,ko:K14128	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2083	Fer4,FlpD,HTH_5
k59_1438762_1	1198232.CYCME_0399	2.56e-79	257.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,45ZQX@72273|Thiotrichales	72273|Thiotrichales	V	ABC transporter transmembrane region	-	-	-	ko:K12541	ko02010,map02010	M00330	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.3,3.A.1.109.4	-	-	ABC_membrane,ABC_tran,Peptidase_C39
k59_1673716_1	768671.ThimaDRAFT_3446	3.06e-76	247.0	COG0189@1|root,COG0454@1|root,COG0189@2|Bacteria,COG0456@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria,1WWH7@135613|Chromatiales	135613|Chromatiales	HJ	ATP-grasp	-	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,RimK
k59_1673716_2	1238182.C882_1361	6.27e-183	526.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,2JQXF@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0367 Asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_1336000_1	1249627.D779_2218	2.42e-108	322.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1WW9F@135613|Chromatiales	135613|Chromatiales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1864331_1	314345.SPV1_09583	3.28e-151	451.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria	1224|Proteobacteria	P	ATPase, P-type transporting, HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_924752_1	765911.Thivi_0060	1.13e-32	115.0	2EGXE@1|root,329EB@2|Bacteria,1NIPX@1224|Proteobacteria,1SHV3@1236|Gammaproteobacteria,1X1VS@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_924752_3	1123392.AQWL01000006_gene638	2.07e-14	76.6	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VHTK@28216|Betaproteobacteria,1KRZ9@119069|Hydrogenophilales	119069|Hydrogenophilales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_45464_2	1484157.PSNIH2_10665	1.34e-59	191.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1RQ1J@1236|Gammaproteobacteria,3VZFJ@53335|Pantoea	1236|Gammaproteobacteria	K	In Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system	uvrY	GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007	-	ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_787571_2	880073.Calab_0897	9.76e-12	70.9	COG0348@1|root,COG1152@1|root,COG0348@2|Bacteria,COG1152@2|Bacteria,2NP1X@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S binding domain	nosG	-	1.2.7.4,2.3.1.169	ko:K00192,ko:K02572,ko:K02573,ko:K14138	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00377,M00422	R07157,R08433,R10243	RC00004,RC00113,RC01144,RC02800,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_5,Fer4_7
k59_102790_1	1278307.KB906976_gene1564	8.84e-288	818.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RNWM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Exporters of the RND superfamily	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_102790_2	1323663.AROI01000011_gene3247	2.01e-89	279.0	COG1502@1|root,COG1502@2|Bacteria	2|Bacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
k59_1268794_1	396588.Tgr7_3002	2.02e-22	97.1	COG0843@1|root,COG0843@2|Bacteria,1QJ23@1224|Proteobacteria,1SKBI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	-	-	-	-	-	-	-	-	-	-	COX1
k59_1268794_2	2340.JV46_24540	5.36e-26	104.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,1J4ZG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	cyoE	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	iJN746.PP_0110	UbiA
k59_615743_1	565045.NOR51B_584	5.01e-104	311.0	COG1253@1|root,COG1253@2|Bacteria,1MWT3@1224|Proteobacteria,1RQBC@1236|Gammaproteobacteria,1J66V@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function DUF21	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
k59_1788274_1	1163617.SCD_n01613	2.58e-168	491.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Ferrous iron transport protein B	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_1864350_1	1121405.dsmv_1458	4.28e-110	332.0	COG4799@1|root,COG4799@2|Bacteria,1Q9BU@1224|Proteobacteria,42P34@68525|delta/epsilon subdivisions,2WK9S@28221|Deltaproteobacteria,2MI0B@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Carboxyl transferase domain	gcdA	-	4.1.1.70	ko:K01615	ko00362,ko00650,ko01120,map00362,map00650,map01120	-	R03028	RC00832	ko00000,ko00001,ko01000,ko02000	3.B.1.1.3	-	-	Carboxyl_trans
k59_1674548_1	1255043.TVNIR_0497	2.1e-30	124.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,1WWT6@135613|Chromatiales	135613|Chromatiales	M	Surface antigen variable number	-	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,POTRA_TamA_1
k59_675991_1	1469245.JFBG01000010_gene599	1.11e-107	337.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,1T1JA@1236|Gammaproteobacteria,1X2PM@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM formate dehydrogenase, alpha subunit	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_323525_1	555779.Dthio_PD2189	9.35e-74	226.0	COG3335@1|root,COG3335@2|Bacteria,1N5WI@1224|Proteobacteria,42R7X@68525|delta/epsilon subdivisions,2WQV8@28221|Deltaproteobacteria,2MEUM@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_323525_2	331678.Cphamn1_1252	3.25e-43	145.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_279317_1	1234364.AMSF01000095_gene2626	3.74e-154	449.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1X453@135614|Xanthomonadales	135614|Xanthomonadales	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
k59_279317_2	396588.Tgr7_2151	2.98e-48	159.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria,1WYDP@135613|Chromatiales	135613|Chromatiales	K	Ribosomal-protein-alanine acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
k59_1731916_1	1123065.ATWL01000002_gene1585	8.22e-08	49.3	2DRA3@1|root,33AVR@2|Bacteria,2GQK2@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
k59_985224_1	1205680.CAKO01000008_gene4166	2.89e-33	129.0	COG0183@1|root,COG0183@2|Bacteria,1MVPC@1224|Proteobacteria,2VEVD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acetyl-coa acetyltransferase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	-
k59_985224_2	1127134.NOCYR_4283	3.1e-07	51.2	COG0494@1|root,COG0494@2|Bacteria,2II41@201174|Actinobacteria,4FUWP@85025|Nocardiaceae	201174|Actinobacteria	L	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_1337412_1	472759.Nhal_3386	9.77e-19	86.7	COG0438@1|root,COG0438@2|Bacteria,1QF9A@1224|Proteobacteria,1RMDT@1236|Gammaproteobacteria,1WW1R@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_1337412_2	748247.AZKH_0602	3.68e-35	125.0	COG1943@1|root,COG1943@2|Bacteria,1P8IT@1224|Proteobacteria,2W5PJ@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
k59_397694_1	471853.Bcav_1103	1.21e-52	185.0	COG1322@1|root,COG1322@2|Bacteria,2GP4U@201174|Actinobacteria	201174|Actinobacteria	S	RmuC domain protein	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
k59_1613617_1	498761.HM1_0291	4.99e-08	55.5	COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,247KE@186801|Clostridia	186801|Clostridia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_323533_1	1121013.P873_01970	4.79e-31	117.0	COG3809@1|root,COG3809@2|Bacteria,1N33W@1224|Proteobacteria,1SASZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-TFIIB
k59_1865713_1	446469.Sked_37980	1.07e-44	157.0	COG1475@1|root,COG1475@2|Bacteria,2GNRN@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the ParB family	parB	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_1204509_1	1172188.KB911825_gene3555	3.28e-98	303.0	COG0489@1|root,COG3944@1|root,COG0489@2|Bacteria,COG3944@2|Bacteria,2GJ1Y@201174|Actinobacteria,4FFZV@85021|Intrasporangiaceae	201174|Actinobacteria	DM	biosynthesis protein	wcoI	-	-	-	-	-	-	-	-	-	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
k59_1379576_1	497964.CfE428DRAFT_3476	6.43e-33	127.0	COG0457@1|root,COG0457@2|Bacteria,46TQ7@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
k59_1141679_1	479435.Kfla_3702	1.09e-88	266.0	COG1119@1|root,COG1119@2|Bacteria,2GIXX@201174|Actinobacteria,4DNDT@85009|Propionibacteriales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	ylmA	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_788239_1	1121271.AUCM01000011_gene2026	6.03e-74	229.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2U7DN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG2148 Sugar transferases involved in lipopolysaccharide synthesis	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
k59_1095371_1	1026882.MAMP_02816	1.31e-184	530.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,45ZNP@72273|Thiotrichales	72273|Thiotrichales	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_557900_1	396588.Tgr7_1275	3.69e-27	107.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1WWD8@135613|Chromatiales	135613|Chromatiales	O	Belongs to the HypD family	-	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
k59_676011_1	1026882.MAMP_00158	1.27e-47	172.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,4603Y@72273|Thiotrichales	72273|Thiotrichales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_147710_1	1122962.AULH01000014_gene900	1.72e-48	169.0	COG1653@1|root,COG1653@2|Bacteria,1R6PD@1224|Proteobacteria,2U3EP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
k59_1674574_1	985054.JQEZ01000002_gene3207	1.73e-23	98.2	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2TSFW@28211|Alphaproteobacteria,4NAFC@97050|Ruegeria	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_1674574_2	536019.Mesop_3996	3.94e-17	76.3	COG3737@1|root,COG3737@2|Bacteria,1N083@1224|Proteobacteria,2UAJD@28211|Alphaproteobacteria,43JZE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
k59_1379585_1	631362.Thi970DRAFT_04978	8.93e-51	167.0	COG0801@1|root,COG0801@2|Bacteria,1RHNN@1224|Proteobacteria,1S62M@1236|Gammaproteobacteria,1WYX8@135613|Chromatiales	135613|Chromatiales	H	PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK	-	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
k59_788244_1	1267005.KB911257_gene944	1.11e-55	176.0	COG2142@1|root,COG2142@2|Bacteria,1MZND@1224|Proteobacteria,2UC3G@28211|Alphaproteobacteria,3N77Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	sdhD	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_1731945_1	472759.Nhal_0495	3.7e-87	267.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1WVUV@135613|Chromatiales	135613|Chromatiales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_926168_1	1043205.AFYF01000051_gene3030	3.08e-06	48.9	2DR0Y@1|root,339QH@2|Bacteria,2GSDX@201174|Actinobacteria,4FI51@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF4235)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4235
k59_926168_2	1713.JOFV01000006_gene2684	1.38e-19	83.6	COG1320@1|root,COG1320@2|Bacteria,2IQXD@201174|Actinobacteria,4F1FT@85016|Cellulomonadaceae	201174|Actinobacteria	P	TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit	mrpG	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_1504078_1	1255043.TVNIR_1350	3.35e-122	380.0	28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria,1S1M3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
k59_46404_1	1249627.D779_1784	2.72e-71	219.0	COG2020@1|root,COG2020@2|Bacteria,1RCMY@1224|Proteobacteria,1S2XW@1236|Gammaproteobacteria,1WY1R@135613|Chromatiales	135613|Chromatiales	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_926172_1	383381.EH30_11810	1.82e-40	143.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2TT1R@28211|Alphaproteobacteria,2K1YI@204457|Sphingomonadales	204457|Sphingomonadales	E	HMGL-like	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
k59_926172_2	644966.Tmar_0947	6.02e-12	65.5	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,3WCVT@538999|Clostridiales incertae sedis	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_985283_1	1048339.KB913029_gene3492	1.03e-27	113.0	COG1200@1|root,COG1200@2|Bacteria,2GKA3@201174|Actinobacteria,4ERTE@85013|Frankiales	201174|Actinobacteria	L	nucleic acid binding OB-fold tRNA helicase-type	recG	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge,tRNA_anti-codon
k59_985283_2	1323361.JPOC01000075_gene3536	6.67e-25	98.6	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4G0U1@85025|Nocardiaceae	201174|Actinobacteria	L	Conserved hypothetical protein 95	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
k59_557916_1	292415.Tbd_2397	1.18e-63	219.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,1KSFJ@119069|Hydrogenophilales	119069|Hydrogenophilales	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_499374_1	1238184.CM001792_gene491	9.3e-21	95.5	COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,4H9QK@91061|Bacilli,23JQI@182709|Oceanobacillus	91061|Bacilli	H	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
k59_985287_1	1283283.ATXA01000004_gene4289	2.56e-84	270.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sulfatase	atsB	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF1269,Sulfatase
k59_1789007_1	1123252.ATZF01000011_gene3131	3.02e-91	297.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,4H9NB@91061|Bacilli,27AZA@186824|Thermoactinomycetaceae	91061|Bacilli	L	TRCF	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_440688_1	298386.PBPRA1988	4.45e-162	490.0	COG0479@1|root,COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0479@2|Bacteria,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1XVUA@135623|Vibrionales	135623|Vibrionales	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_397762_1	1121923.GPUN_2248	5.75e-77	242.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,464UB@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0668 Small-conductance mechanosensitive channel	mscS	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel,TM_helix
k59_1269696_1	396588.Tgr7_0774	8.6e-157	449.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1WVUV@135613|Chromatiales	135613|Chromatiales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_676039_1	1163617.SCD_n02497	1.49e-77	243.0	COG2010@1|root,COG3439@1|root,COG2010@2|Bacteria,COG3439@2|Bacteria,1R6Z0@1224|Proteobacteria,2VRTH@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,DUF302
k59_323569_1	1163617.SCD_n00492	3.02e-99	302.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,2VJCC@28216|Betaproteobacteria	28216|Betaproteobacteria	M	mechanosensitive ion channel	ynaI	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
k59_1337493_2	1265503.KB905162_gene3509	3.01e-21	94.0	COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,1SND8@1236|Gammaproteobacteria,2Q86D@267889|Colwelliaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1865779_1	1384056.N787_12830	2.66e-20	92.8	COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1RKGT@1224|Proteobacteria,1S6ZQ@1236|Gammaproteobacteria,1X563@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the ompA family	mopB	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OMP_b-brl,OmpA,TSP_3
k59_46425_1	192952.MM_2866	1.23e-57	201.0	arCOG05210@1|root,arCOG05210@2157|Archaea,2Y4FW@28890|Euryarchaeota,2NB4Z@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_323586_1	765911.Thivi_0731	1.61e-62	195.0	2BW2S@1|root,32QYV@2|Bacteria,1RI5M@1224|Proteobacteria,1S614@1236|Gammaproteobacteria,1WYK8@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_147755_1	926550.CLDAP_16210	1.99e-45	152.0	COG0572@1|root,COG0572@2|Bacteria,2G6D5@200795|Chloroflexi	200795|Chloroflexi	F	Cytidine monophosphokinase	udk	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
k59_1204570_1	367299.JOEE01000001_gene1508	1.27e-106	318.0	COG3239@1|root,COG3239@2|Bacteria,2H2JW@201174|Actinobacteria,4FFD7@85021|Intrasporangiaceae	201174|Actinobacteria	I	fatty acid desaturase	desA3	-	1.14.19.3	ko:K00508	ko00591,ko01100,map00591,map01100	-	R07063	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
k59_1555488_1	1283300.ATXB01000002_gene2651	4.41e-98	304.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1XERH@135618|Methylococcales	135618|Methylococcales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1555488_2	34506.g3249	2.29e-18	85.5	COG0275@1|root,KOG2782@2759|Eukaryota,38UFJ@33154|Opisthokonta,3BEK8@33208|Metazoa,3CUSP@33213|Bilateria	33208|Metazoa	M	rRNA (cytosine-N4-)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_5
k59_1620311_1	1172188.KB911820_gene2201	5.13e-76	249.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria,4FFS7@85021|Intrasporangiaceae	201174|Actinobacteria	O	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1562139_1	1049564.TevJSym_ad00280	1.81e-104	318.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1J4U3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CP	CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	-	-	1.6.5.3	ko:K05577	ko00190,ko01100,map00190,map01100	M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	-	-	-	Proton_antipo_M,Proton_antipo_N
k59_447345_1	768671.ThimaDRAFT_0873	5.4e-153	446.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGB@1236|Gammaproteobacteria,1X1MI@135613|Chromatiales	135613|Chromatiales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1681069_1	1212548.B381_03097	3.31e-62	195.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
k59_407898_1	593907.Celgi_1627	7.33e-194	556.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4F0RF@85016|Cellulomonadaceae	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_407898_2	1385521.N803_08730	5.74e-28	111.0	COG0237@1|root,COG2320@1|root,COG0237@2|Bacteria,COG2320@2|Bacteria,2GN96@201174|Actinobacteria,4FE98@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE,GrpB
k59_741537_1	1380354.JIAN01000006_gene777	1.6e-61	197.0	COG1579@1|root,COG1579@2|Bacteria,2GP84@201174|Actinobacteria,4F15G@85016|Cellulomonadaceae	201174|Actinobacteria	S	C4-type zinc ribbon domain	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
k59_1738665_1	1123368.AUIS01000009_gene2453	1.17e-121	353.0	COG0842@1|root,COG0842@2|Bacteria,1MUF4@1224|Proteobacteria,1T54P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
k59_623171_1	590998.Celf_2891	5.69e-56	185.0	COG0739@1|root,COG0739@2|Bacteria,2GKXN@201174|Actinobacteria,4F158@85016|Cellulomonadaceae	201174|Actinobacteria	M	heme binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1511522_1	1163617.SCD_n02038	8.36e-57	189.0	COG0191@1|root,COG0191@2|Bacteria,1R6TC@1224|Proteobacteria,2VMUH@28216|Betaproteobacteria	28216|Betaproteobacteria	G	ketose-bisphosphate aldolase	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
k59_995231_1	1132855.KB913035_gene2520	7.27e-34	118.0	COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,2VUN8@28216|Betaproteobacteria,2KMX7@206350|Nitrosomonadales	206350|Nitrosomonadales	E	PFAM phosphoribosyl-ATP pyrophosphohydrolase	hisE	-	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
k59_995231_2	1479237.JMLY01000001_gene16	9.19e-70	213.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,4679A@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_5014	PRA-CH,PRA-PH
k59_935986_1	502025.Hoch_2634	2.56e-69	216.0	COG0778@1|root,COG0778@2|Bacteria,1PG5G@1224|Proteobacteria,431RK@68525|delta/epsilon subdivisions,2WWKP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_114393_1	1123296.JQKE01000017_gene1778	2.72e-24	105.0	COG1181@1|root,COG1181@2|Bacteria,1R86N@1224|Proteobacteria,2VYXM@28216|Betaproteobacteria	28216|Betaproteobacteria	M	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
k59_1681082_1	1173028.ANKO01000006_gene2043	2.92e-73	230.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	2.6.1.106	ko:K16436	ko00523,ko01055,ko01130,map00523,map01055,map01130	M00797,M00800,M00803	R06426,R06631,R08928	RC00006,RC01514,RC03347	ko00000,ko00001,ko00002,ko01000	-	-	-	DegT_DnrJ_EryC1
k59_935989_1	29581.BW37_03432	1.59e-54	186.0	COG1249@1|root,COG1249@2|Bacteria,1MXQ3@1224|Proteobacteria,2VK4G@28216|Betaproteobacteria,475TK@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	pdhD	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1562160_1	399741.Spro_0843	1.5e-54	196.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,400VD@613|Serratia	1236|Gammaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_1147683_1	1121935.AQXX01000060_gene1980	7.77e-26	105.0	COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,1RQRT@1236|Gammaproteobacteria,1XPQ5@135619|Oceanospirillales	135619|Oceanospirillales	O	XdhC and CoxI family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
k59_1147683_2	1121033.AUCF01000005_gene5222	5.45e-13	70.5	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2TR5D@28211|Alphaproteobacteria,2JPR6@204441|Rhodospirillales	204441|Rhodospirillales	H	Probable molybdopterin binding domain	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
k59_506030_1	323261.Noc_1194	2.62e-63	197.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,1S4H7@1236|Gammaproteobacteria,1WYAR@135613|Chromatiales	135613|Chromatiales	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_1794897_1	335543.Sfum_0393	2.24e-28	112.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42MMF@68525|delta/epsilon subdivisions,2WJ1F@28221|Deltaproteobacteria,2MRA9@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
k59_1386358_1	2340.JV46_13040	3.57e-183	519.0	COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J85H@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N,Transketolase_C
k59_1347779_1	713587.THITH_16065	6.68e-35	127.0	COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria,1WXWD@135613|Chromatiales	135613|Chromatiales	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
k59_1511534_1	742823.HMPREF9465_01106	5.61e-75	236.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2VHJY@28216|Betaproteobacteria,4PQQN@995019|Sutterellaceae	28216|Betaproteobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_1277348_1	323259.Mhun_1141	3.3e-78	258.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,2N916@224756|Methanomicrobia	224756|Methanomicrobia	G	PEP-utilising enzyme, TIM barrel domain	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_154652_1	1458427.BAWN01000022_gene1422	2.5e-95	287.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2W19X@28216|Betaproteobacteria,4ABCC@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_858118_1	768671.ThimaDRAFT_3385	4.55e-129	381.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RNPY@1236|Gammaproteobacteria,1WWN2@135613|Chromatiales	135613|Chromatiales	O	PFAM peptidase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
k59_858118_2	1042377.AFPJ01000052_gene1574	8.18e-27	102.0	COG2983@1|root,COG2983@2|Bacteria,1RHMX@1224|Proteobacteria,1S5XU@1236|Gammaproteobacteria,46785@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Belongs to the UPF0260 family	ycgN	-	-	ko:K09160	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_793593_1	1123368.AUIS01000008_gene2143	2.41e-41	149.0	COG2048@1|root,COG2048@2|Bacteria,1R97P@1224|Proteobacteria,1SJXJ@1236|Gammaproteobacteria,2NC1I@225057|Acidithiobacillales	225057|Acidithiobacillales	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_793593_2	371731.Rsw2DRAFT_3298	3.45e-26	105.0	COG0446@1|root,COG1148@1|root,COG0446@2|Bacteria,COG1148@2|Bacteria,1R882@1224|Proteobacteria,2U526@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD dependent oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Pyr_redox_2
k59_564585_1	675635.Psed_1667	6.17e-93	297.0	COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria,4DX4E@85010|Pseudonocardiales	201174|Actinobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_213048_1	589865.DaAHT2_0196	1.47e-41	154.0	COG2025@1|root,COG2086@1|root,COG2025@2|Bacteria,COG2086@2|Bacteria,1MUFI@1224|Proteobacteria,42M3T@68525|delta/epsilon subdivisions,2WIV8@28221|Deltaproteobacteria,2MIMG@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein, alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
k59_330434_1	1429851.X548_14385	5.95e-29	117.0	COG0475@1|root,COG0475@2|Bacteria,1RA3J@1224|Proteobacteria,1RWKQ@1236|Gammaproteobacteria,1X47M@135614|Xanthomonadales	135614|Xanthomonadales	P	Na h exchange protein	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_793608_2	1144319.PMI16_04123	2.13e-48	174.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2VP95@28216|Betaproteobacteria,476IM@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_1,TPR_16,TPR_2,TPR_6,TPR_8
k59_1102814_1	1265502.KB905953_gene748	1.53e-107	323.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2VI2V@28216|Betaproteobacteria,4A9Q6@80864|Comamonadaceae	28216|Betaproteobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_1620367_1	981384.AEYW01000005_gene3066	2.75e-05	50.8	COG3591@1|root,COG3591@2|Bacteria,1MXUN@1224|Proteobacteria,2U5EK@28211|Alphaproteobacteria,4NBVZ@97050|Ruegeria	28211|Alphaproteobacteria	E	Trypsin-like serine protease	-	-	-	ko:K04775	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Trypsin,Trypsin_2
k59_407969_1	1166016.W5S_0240	3.83e-51	177.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1MQRJ@122277|Pectobacterium	1236|Gammaproteobacteria	F	bifunctional purine biosynthesis protein PurH	purH	GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iEcHS_1320.EcHS_A4240,iPC815.YPO3728	AICARFT_IMPCHas,MGS
k59_407969_2	339671.Asuc_0648	3.97e-24	94.7	COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,1SD35@1236|Gammaproteobacteria,1Y8SU@135625|Pasteurellales	135625|Pasteurellales	K	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters	fis	GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0032991,GO:0032993,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815	-	ko:K03557	ko05111,map05111	-	-	-	ko00000,ko00001,ko03000,ko03036,ko03400	-	-	-	HTH_8
k59_330441_1	1095767.CAHD01000159_gene2942	2.88e-47	168.0	COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria,4F0PF@85016|Cellulomonadaceae	201174|Actinobacteria	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_1511561_1	1294273.roselon_00985	1.14e-37	134.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,2TS2U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	NU	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_741591_1	639283.Snov_2487	2.64e-72	226.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2TR0T@28211|Alphaproteobacteria,3EXVP@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	ATPase family associated with various cellular activities (AAA)	moxR	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_936051_1	218491.ECA0261	1.85e-19	82.4	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,1MPS0@122277|Pectobacterium	1236|Gammaproteobacteria	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	iYL1228.KPN_03664	Biotin_lipoyl
k59_447405_1	1166948.JPZL01000003_gene500	1.27e-69	223.0	COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1XIGP@135619|Oceanospirillales	135619|Oceanospirillales	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_114461_1	1122185.N792_04310	1.6e-21	90.5	COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,1X4KC@135614|Xanthomonadales	135614|Xanthomonadales	L	Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis	rnt	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360	-	ko:K03683	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_T
k59_1794931_1	335543.Sfum_2658	2.38e-76	245.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,PAS,PAS_3,PAS_9,Response_reg
k59_1738725_1	1279017.AQYJ01000022_gene2610	1.28e-16	84.7	2ASXF@1|root,31ID0@2|Bacteria,1RM30@1224|Proteobacteria,1S8I2@1236|Gammaproteobacteria,46BFQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1029938_1	367299.JOEE01000003_gene2747	6.03e-99	293.0	COG0204@1|root,COG0204@2|Bacteria,2GKM6@201174|Actinobacteria,4FEZZ@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acyltransferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_1386393_1	1123073.KB899241_gene2918	4.01e-81	248.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1X4GY@135614|Xanthomonadales	135614|Xanthomonadales	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_1386393_2	1049564.TevJSym_at00400	1.87e-62	200.0	COG3165@1|root,COG3165@2|Bacteria,1R1CM@1224|Proteobacteria,1S1SM@1236|Gammaproteobacteria,1J6XG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	yigP	-	-	ko:K03690	-	-	-	-	ko00000	-	-	-	SCP2
k59_114465_1	1349820.M707_07815	1.87e-26	104.0	COG1682@1|root,COG1682@2|Bacteria,2GP5K@201174|Actinobacteria,1W855@1268|Micrococcaceae	201174|Actinobacteria	GM	Transport permease protein	wzm	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_114465_2	266940.Krad_3885	1.44e-126	366.0	COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria	201174|Actinobacteria	GM	ABC transporter	rfbB2	-	3.6.3.40	ko:K01990,ko:K09691,ko:K09693	ko02010,map02010	M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.103,3.A.1.104	-	-	ABC_tran,Wzt_C
k59_114465_3	930171.Asphe3_25630	1.15e-16	77.0	COG0110@1|root,COG0110@2|Bacteria,2H5M0@201174|Actinobacteria,1W9C6@1268|Micrococcaceae	201174|Actinobacteria	S	Hexapeptide repeat of succinyl-transferase	wbpD	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
k59_624196_2	246195.DNO_0301	8.81e-14	73.2	COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,1RNPD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity	zapD	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0007049,GO:0008150,GO:0009987,GO:0019954,GO:0022402,GO:0022414,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044424,GO:0044444,GO:0044464,GO:0051301	-	ko:K18778	-	-	-	-	ko00000,ko03036	-	-	-	ZapD
k59_289853_1	187272.Mlg_1865	6.48e-164	489.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales	135613|Chromatiales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2
k59_683949_2	1280674.AUJK01000030_gene2050	1.66e-13	73.6	COG1198@1|root,COG1198@2|Bacteria,4NFHB@976|Bacteroidetes,2FN6Z@200643|Bacteroidia	976|Bacteroidetes	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_1349302_1	1291050.JAGE01000001_gene2893	1.1e-68	217.0	COG2801@1|root,COG2801@2|Bacteria,1TU21@1239|Firmicutes,249HN@186801|Clostridia,3WJ0S@541000|Ruminococcaceae	186801|Clostridia	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_1278341_1	1123065.ATWL01000008_gene2426	9.26e-137	393.0	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria	201174|Actinobacteria	G	inositol monophosphatase	hisN	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15,3.1.3.25	ko:K01092,ko:K05602	ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00131	R01185,R01186,R01187,R03013	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_1621293_1	717785.HYPMC_3868	8.56e-73	237.0	COG1793@1|root,COG1793@2|Bacteria,1MV3S@1224|Proteobacteria,2TRQ9@28211|Alphaproteobacteria,3N63T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DNA ligase	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
k59_996845_1	765912.Thimo_1210	5.08e-78	235.0	COG1765@1|root,COG1765@2|Bacteria,1N1RR@1224|Proteobacteria,1S3KI@1236|Gammaproteobacteria,1WY57@135613|Chromatiales	135613|Chromatiales	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
k59_683958_1	640512.BC1003_2665	3.91e-45	166.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2VJ68@28216|Betaproteobacteria,1K2UW@119060|Burkholderiaceae	28216|Betaproteobacteria	E	aminopeptidase N	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
k59_331489_1	1049564.TevJSym_ap00050	7.67e-89	286.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J57S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	cation transport ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
k59_57219_1	349124.Hhal_2302	2.3e-62	199.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,1RMFR@1236|Gammaproteobacteria,1WWRE@135613|Chromatiales	135613|Chromatiales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
k59_57219_2	754477.Q7C_609	6.02e-33	123.0	COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,460I1@72273|Thiotrichales	72273|Thiotrichales	D	Part of the ABC transporter FtsEX involved in cellular division	-	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
k59_742629_1	1049564.TevJSym_ap00050	5.65e-92	293.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J57S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	cation transport ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
k59_1795805_1	1101189.AQUO01000001_gene2023	2.13e-54	170.0	COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2UD7K@28211|Alphaproteobacteria,2PZ9E@265|Paracoccus	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1795805_2	1367847.JCM7686_pAMI4p359	6.63e-55	178.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2PVSB@265|Paracoccus	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve,rve_3
k59_289878_2	1037409.BJ6T_32510	1.64e-12	68.2	COG0583@1|root,COG0583@2|Bacteria,1R785@1224|Proteobacteria,2U47K@28211|Alphaproteobacteria,3JXFZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1148613_1	1121405.dsmv_3795	1.54e-54	181.0	28J8Y@1|root,2Z943@2|Bacteria,1REXC@1224|Proteobacteria,43DCS@68525|delta/epsilon subdivisions,2X8IT@28221|Deltaproteobacteria,2MK0X@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4338
k59_1387344_1	572477.Alvin_0800	1.02e-98	303.0	COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1WWFZ@135613|Chromatiales	135613|Chromatiales	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase
k59_565641_1	670307.HYPDE_28428	6.78e-46	160.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2U0K2@28211|Alphaproteobacteria,3N6RA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Ami_3	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
k59_1103897_1	471853.Bcav_2208	7.91e-107	315.0	COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	pdtaR	GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
k59_1877620_1	1120705.FG95_02358	7.1e-34	137.0	COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2U1YP@28211|Alphaproteobacteria,2K2T9@204457|Sphingomonadales	204457|Sphingomonadales	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_214026_1	926550.CLDAP_26890	1.97e-71	227.0	COG1454@1|root,COG1454@2|Bacteria,2G6IU@200795|Chloroflexi	200795|Chloroflexi	C	PFAM iron-containing alcohol dehydrogenase	-	-	1.1.1.1,1.1.99.24	ko:K00001,ko:K11173,ko:K13954	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
k59_115966_1	42565.FP66_02560	1.63e-75	236.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1XHMA@135619|Oceanospirillales	135619|Oceanospirillales	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_57246_1	497964.CfE428DRAFT_4984	1.06e-88	283.0	COG1198@1|root,COG1198@2|Bacteria,46U3N@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_683980_1	552811.Dehly_0526	7.73e-115	338.0	COG1260@1|root,COG1260@2|Bacteria,2G5YH@200795|Chloroflexi,34CJX@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
k59_1211856_1	1174504.AJTN02000035_gene3043	4.92e-31	123.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HC4S@91061|Bacilli,1ZQZX@1386|Bacillus	91061|Bacilli	C	acyl-CoA transferases carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_742654_1	926564.KI911710_gene2859	2.47e-41	142.0	COG1670@1|root,COG1670@2|Bacteria,2IKXU@201174|Actinobacteria,4F3VQ@85017|Promicromonosporaceae	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_742654_2	743718.Isova_2190	1.06e-71	231.0	COG0064@1|root,COG0064@2|Bacteria,2GJJH@201174|Actinobacteria,4F3EP@85017|Promicromonosporaceae	201174|Actinobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_1512581_1	935839.JAGJ01000015_gene2100	4.96e-81	252.0	COG1181@1|root,COG1181@2|Bacteria,2GRWM@201174|Actinobacteria,4F3P7@85017|Promicromonosporaceae	201174|Actinobacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_513701_1	1249627.D779_1388	7.91e-132	381.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,1RMXS@1236|Gammaproteobacteria,1WW0T@135613|Chromatiales	135613|Chromatiales	E	PFAM Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
k59_513701_2	322710.Avin_03210	9.74e-17	78.6	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iUTI89_1310.UTI89_C0772,iZ_1308.Z0993	Aminotran_3
k59_1689352_1	171693.BN988_01574	1.34e-06	55.8	COG0730@1|root,COG0730@2|Bacteria,1TPMA@1239|Firmicutes,4HCYJ@91061|Bacilli,23JT3@182709|Oceanobacillus	91061|Bacilli	S	Sulfite exporter TauE/SafE	yunE	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_632282_2	1288083.AUKR01000023_gene481	1.84e-10	60.8	COG2963@1|root,COG2963@2|Bacteria,2IMAC@201174|Actinobacteria	201174|Actinobacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_1690614_1	765912.Thimo_0766	2.42e-59	184.0	COG4451@1|root,COG4451@2|Bacteria,1R9ZE@1224|Proteobacteria,1S3XZ@1236|Gammaproteobacteria,1X23Q@135613|Chromatiales	135613|Chromatiales	C	PFAM Ribulose bisphosphate carboxylase, small chain	-	-	4.1.1.39	ko:K01602	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_small
k59_1747935_1	243090.RB8939	4.47e-09	57.4	COG0640@1|root,COG0640@2|Bacteria,2J3B8@203682|Planctomycetes	203682|Planctomycetes	K	Bacterial regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
k59_1220363_1	1163617.SCD_n02608	5.93e-05	44.7	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2VIZB@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	ko:K11102	-	-	-	-	ko00000,ko02000	2.A.23.1.1,2.A.23.1.2	-	-	SDF
k59_867984_1	1125863.JAFN01000001_gene3086	3.57e-46	160.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42P5W@68525|delta/epsilon subdivisions,2WMA6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_800470_2	1163409.UUA_05732	2.43e-35	139.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1X2XN@135614|Xanthomonadales	135614|Xanthomonadales	M	penicillin-binding protein	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_1455696_1	765910.MARPU_04245	6.83e-35	129.0	COG0583@1|root,COG0583@2|Bacteria,1MVHT@1224|Proteobacteria,1RN7G@1236|Gammaproteobacteria,1WXTT@135613|Chromatiales	135613|Chromatiales	K	PFAM HTH transcriptional regulator, LysR	-	-	-	ko:K03717	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_339874_1	314285.KT71_02627	1.44e-48	174.0	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S0KQ@1236|Gammaproteobacteria,1J82F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_221890_1	640081.Dsui_0508	3.39e-90	288.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,2KUYS@206389|Rhodocyclales	206389|Rhodocyclales	C	nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC	napA	-	-	ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1455698_1	1312954.KI914883_gene1539	3.14e-30	119.0	COG0582@1|root,COG0582@2|Bacteria,2GISN@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	int8	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
k59_1113652_2	1123366.TH3_18684	5.94e-54	176.0	COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,2UBYU@28211|Alphaproteobacteria,2JTKP@204441|Rhodospirillales	204441|Rhodospirillales	C	Prokaryotic cytochrome b561	-	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
k59_1395359_1	4555.Si006533m	0.000607	48.5	COG0666@1|root,2QR1Y@2759|Eukaryota,37IVM@33090|Viridiplantae,3GBNF@35493|Streptophyta,3KVWT@4447|Liliopsida,3IFZA@38820|Poales	35493|Streptophyta	O	Ankyrin repeat	-	GO:0003674,GO:0003824,GO:0004842,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016567,GO:0016740,GO:0019538,GO:0019787,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070647,GO:0071704,GO:0140096,GO:1901564	2.3.2.27	ko:K19044	-	-	-	-	ko00000,ko01000,ko04121	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5
k59_1040123_1	765912.Thimo_1292	2.15e-57	186.0	COG0847@1|root,COG0847@2|Bacteria,1RAF1@1224|Proteobacteria,1S9PP@1236|Gammaproteobacteria,1WWV8@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_1113655_1	631362.Thi970DRAFT_02291	6.33e-128	387.0	COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,1WWRD@135613|Chromatiales	135613|Chromatiales	M	HAD-superfamily hydrolase, subfamily IIB	-	-	2.4.1.14	ko:K00696	ko00500,ko01100,map00500,map01100	-	R00766	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth
k59_1040127_1	556268.OFAG_00391	2.94e-217	628.0	COG1204@1|root,COG1204@2|Bacteria,1PG9I@1224|Proteobacteria,2WCVD@28216|Betaproteobacteria,4789R@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
k59_1220384_1	523791.Kkor_1874	4.68e-51	179.0	COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria,1XIQ4@135619|Oceanospirillales	135619|Oceanospirillales	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_1522510_1	1116472.MGMO_8c00560	8.13e-64	199.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,1XF3J@135618|Methylococcales	135618|Methylococcales	C	TIGRFAM SUF system FeS	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
k59_750722_1	1150600.ADIARSV_1273	9.08e-11	63.2	COG3222@1|root,COG3222@2|Bacteria,4NM7F@976|Bacteroidetes,1ISU2@117747|Sphingobacteriia	976|Bacteroidetes	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
k59_750722_2	713586.KB900536_gene513	7.48e-62	195.0	29GYT@1|root,303WG@2|Bacteria,1RET9@1224|Proteobacteria,1S6VD@1236|Gammaproteobacteria,1X0VV@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_750722_3	1177181.T9A_00322	9.66e-07	54.7	COG2153@1|root,COG2153@2|Bacteria,1NIM6@1224|Proteobacteria,1SHTY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein acetylation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1395371_1	713586.KB900536_gene3082	3.06e-57	203.0	COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QUWB@1224|Proteobacteria,1T23G@1236|Gammaproteobacteria,1X2J6@135613|Chromatiales	135613|Chromatiales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_1522522_1	522306.CAP2UW1_3932	1.23e-32	126.0	COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,2VIYN@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Periplasmic copper-binding	-	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
k59_455996_1	863365.XHC_3963	7.27e-44	154.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,1X4QH@135614|Xanthomonadales	135614|Xanthomonadales	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_1571508_1	1408224.SAMCCGM7_c1848	4.54e-11	69.3	COG2706@1|root,COG2931@1|root,COG3391@1|root,COG4932@1|root,COG2706@2|Bacteria,COG2931@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,4B9MG@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,HCBP_related,HemolysinCabind,Lipase_GDSL_2,P_proprotein,Peptidase_S8
k59_868032_1	1255043.TVNIR_3194	8.19e-79	256.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1WWE3@135613|Chromatiales	135613|Chromatiales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1288460_1	983328.AFGH01000030_gene551	8.22e-27	107.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2YMZW@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_1288460_2	1218108.KB908292_gene1537	4.75e-05	44.7	2EHBZ@1|root,33B3U@2|Bacteria,4NZK3@976|Bacteroidetes,1I71Q@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_750755_1	1380358.JADJ01000029_gene4043	2.83e-32	122.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1XIAX@135619|Oceanospirillales	135619|Oceanospirillales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_750755_2	1123256.KB907926_gene645	9.42e-07	49.3	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria,1X3CN@135614|Xanthomonadales	135614|Xanthomonadales	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
k59_800509_1	744980.TRICHSKD4_4797	1.08e-82	262.0	COG0330@1|root,COG0330@2|Bacteria,1MW1D@1224|Proteobacteria,2TRE5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_1571524_1	666684.AfiDRAFT_0149	1.14e-69	221.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,3JQZ0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	tdcB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006520,GO:0006563,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016841,GO:0016853,GO:0016854,GO:0016855,GO:0017144,GO:0018249,GO:0019538,GO:0019752,GO:0019842,GO:0030170,GO:0030378,GO:0030848,GO:0036094,GO:0036211,GO:0036361,GO:0042219,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046416,GO:0046437,GO:0046872,GO:0047661,GO:0048037,GO:0050662,GO:0070178,GO:0070179,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_339921_2	472759.Nhal_0831	1.38e-10	60.8	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,1S4U5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	serine threonine protein phosphatase	-	-	3.1.3.16	ko:K01090,ko:K11890,ko:K20074	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000,ko01009,ko02044	-	-	-	PP2C_2
k59_1629666_1	1121405.dsmv_2934	2.39e-85	268.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,42N6D@68525|delta/epsilon subdivisions,2X5IJ@28221|Deltaproteobacteria,2MI9M@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Carboxyl transferase domain	mccB	-	6.4.1.4,6.4.1.5	ko:K01969,ko:K13778	ko00280,ko00281,ko01100,map00280,map00281,map01100	M00036	R03494,R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3290	Carboxyl_trans
k59_632357_1	983917.RGE_07310	7.95e-30	114.0	COG1075@1|root,COG1075@2|Bacteria,1NJNA@1224|Proteobacteria,2VPNT@28216|Betaproteobacteria,1KNTZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,PGAP1
k59_632357_2	1120936.KB907220_gene1988	6.79e-26	107.0	COG0657@1|root,COG0657@2|Bacteria,2GTEV@201174|Actinobacteria,4EPWP@85012|Streptosporangiales	201174|Actinobacteria	I	Carboxylesterase family	lipM	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
k59_1113728_2	469610.HMPREF0189_01341	2.4e-43	156.0	COG0477@1|root,COG2814@2|Bacteria,1R3WC@1224|Proteobacteria,2VKT9@28216|Betaproteobacteria,1KKFE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1288493_1	484770.UFO1_0921	2.05e-26	109.0	COG0715@1|root,COG0715@2|Bacteria,1UY07@1239|Firmicutes,4H26X@909932|Negativicutes	909932|Negativicutes	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
k59_456014_1	631362.Thi970DRAFT_04885	1.49e-91	293.0	COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,1RPD2@1236|Gammaproteobacteria,1WXID@135613|Chromatiales	135613|Chromatiales	S	doubled CXXCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Paired_CXXCH_1,TPR_19,TPR_8
k59_868060_1	365046.Rta_33710	3.52e-71	222.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VJAP@28216|Betaproteobacteria,4AA6B@80864|Comamonadaceae	28216|Betaproteobacteria	C	Cytochrome c oxidase subunit III	coxC	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_1288494_2	1038858.AXBA01000017_gene1083	3.92e-38	132.0	2D1BA@1|root,32TAA@2|Bacteria,1RJQD@1224|Proteobacteria,2U780@28211|Alphaproteobacteria,3F02D@335928|Xanthobacteraceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1455765_1	768671.ThimaDRAFT_0602	6.29e-135	420.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW08@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1040208_2	446470.Snas_0649	1.48e-13	69.3	COG0640@1|root,COG0640@2|Bacteria,2IM1K@201174|Actinobacteria,4F08K@85014|Glycomycetales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
k59_339937_1	1379270.AUXF01000005_gene747	8.96e-75	248.0	COG0542@1|root,COG0542@2|Bacteria,1ZT9Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1220449_1	187272.Mlg_2135	8.25e-35	129.0	COG0826@1|root,COG0826@2|Bacteria,1MWFW@1224|Proteobacteria,1RMWM@1236|Gammaproteobacteria,1WVVX@135613|Chromatiales	135613|Chromatiales	O	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_U32
k59_1220449_2	557598.LHK_00306	5.9e-13	67.8	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VH51@28216|Betaproteobacteria,2KPRJ@206351|Neisseriales	206351|Neisseriales	O	Peptidase, U32 family	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
k59_456027_1	643867.Ftrac_0474	6.62e-72	233.0	COG0604@1|root,COG0604@2|Bacteria,4NF0Z@976|Bacteroidetes,47XCM@768503|Cytophagia	976|Bacteroidetes	C	COGs COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_1288528_1	396588.Tgr7_0226	2.48e-110	333.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WX5F@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_573325_1	1047013.AQSP01000124_gene2678	2.96e-58	187.0	COG3167@1|root,COG3167@2|Bacteria,2NPUF@2323|unclassified Bacteria	2|Bacteria	NU	Pilus assembly protein, PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
k59_1113775_1	335543.Sfum_1469	1.08e-138	400.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,42MK7@68525|delta/epsilon subdivisions,2WJCJ@28221|Deltaproteobacteria,2MRHZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Fructose-bisphosphate aldolase class-II	fbaA	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
k59_1288536_1	314278.NB231_05791	6.43e-81	249.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1WW9Z@135613|Chromatiales	135613|Chromatiales	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
k59_1155806_1	96561.Dole_2003	1.97e-46	160.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,42MVD@68525|delta/epsilon subdivisions,2WIY3@28221|Deltaproteobacteria,2MIPS@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1113795_1	156889.Mmc1_2138	7.92e-12	64.3	COG3090@1|root,COG3090@2|Bacteria,1R3YK@1224|Proteobacteria,2TU4N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	dctQ	-	-	ko:K11689	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
k59_1113795_2	156889.Mmc1_2137	1.95e-62	204.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system large permease component	dctM	GO:0005575,GO:0016020,GO:0016021,GO:0031224,GO:0044425	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM,DctQ
k59_868116_1	1265505.ATUG01000003_gene496	9.83e-07	53.1	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,42NAX@68525|delta/epsilon subdivisions,2WJF5@28221|Deltaproteobacteria,2MIA9@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Putative nucleotidyltransferase substrate binding domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,PAS_8,cNMP_binding,sCache_2
k59_750814_1	1049564.TevJSym_af00840	5.32e-62	209.0	COG3249@1|root,COG3249@2|Bacteria,1N0PD@1224|Proteobacteria,1S9C4@1236|Gammaproteobacteria,1J69V@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	VV2512	-	-	ko:K09938	-	-	-	-	ko00000	-	-	-	DUF2066
k59_750814_2	413404.Rmag_0267	6.17e-27	104.0	COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,1SAHT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA2	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_1220480_1	1144312.PMI09_00843	2.36e-91	280.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria,4B7GK@82115|Rhizobiaceae	28211|Alphaproteobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
k59_1155810_1	413816.BBJP01000027_gene1834	4.55e-31	127.0	COG0145@1|root,arCOG01511@2157|Archaea,2XT1J@28890|Euryarchaeota,23SV5@183963|Halobacteria	183963|Halobacteria	E	COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit	hyuA1	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k59_1455821_1	880072.Desac_0637	1.66e-50	174.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42MMF@68525|delta/epsilon subdivisions,2WJ1F@28221|Deltaproteobacteria,2MRA9@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
k59_868121_1	1121439.dsat_1312	8.36e-12	72.8	COG0308@1|root,COG0308@2|Bacteria,1PEPK@1224|Proteobacteria,42NJ8@68525|delta/epsilon subdivisions,2WM57@28221|Deltaproteobacteria,2MA7F@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_0348	Peptidase_M1
k59_1690759_1	1120959.ATXF01000008_gene614	1.37e-51	184.0	COG1483@1|root,COG1483@2|Bacteria,2GMTG@201174|Actinobacteria	201174|Actinobacteria	S	ATPase (AAA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_800553_1	1521187.JPIM01000002_gene3139	1.17e-106	317.0	COG0409@1|root,COG0409@2|Bacteria,2G5MS@200795|Chloroflexi,376PX@32061|Chloroflexia	32061|Chloroflexia	O	TIGRFAM hydrogenase expression formation protein HypD	-	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
k59_1040281_1	379066.GAU_3117	8.31e-53	188.0	COG4447@1|root,COG4447@2|Bacteria,1ZSRH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
k59_1522663_1	1500893.JQNB01000001_gene1344	3.77e-15	76.3	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1X43I@135614|Xanthomonadales	135614|Xanthomonadales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1522663_2	631362.Thi970DRAFT_03484	9.35e-74	224.0	2AAM4@1|root,30ZYM@2|Bacteria,1RFTG@1224|Proteobacteria,1S4UQ@1236|Gammaproteobacteria,1WYA8@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_573352_1	439235.Dalk_1464	4.29e-43	154.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,43B8Z@68525|delta/epsilon subdivisions,2X6NB@28221|Deltaproteobacteria,2MPI8@213118|Desulfobacterales	1224|Proteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_163874_1	1049564.TevJSym_as00660	3.14e-11	64.3	COG1033@1|root,COG2409@1|root,COG1033@2|Bacteria,COG2409@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,1J5BG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	MMPL family	IV02_10640	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_163874_2	1049564.TevJSym_as00670	2.48e-42	153.0	COG3103@1|root,COG3103@2|Bacteria,1MVX1@1224|Proteobacteria,1S3BH@1236|Gammaproteobacteria,1J9WR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Sh3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AMIN
k59_1040294_1	1036674.A28LD_0978	1.2e-36	139.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1S3EU@1236|Gammaproteobacteria,2QGY6@267893|Idiomarinaceae	1236|Gammaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_691787_1	314285.KT71_15019	1.01e-66	219.0	COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,1RPU1@1236|Gammaproteobacteria,1J8UX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494	1.6.5.8	ko:K00346	-	-	-	-	ko00000,ko01000	-	-	-	NQRA,NQRA_SLBB
k59_1288584_1	1191523.MROS_0083	1.13e-65	226.0	2DB7A@1|root,2Z7KK@2|Bacteria	2|Bacteria	S	COG NOG06097 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_115
k59_1220500_1	883.DvMF_0823	2.44e-54	186.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M7UM@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1690776_1	1230342.CTM_03975	5.42e-59	202.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,36DIR@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
k59_1572985_1	1304883.KI912532_gene2878	6.1e-18	84.0	COG2202@1|root,COG2203@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VI6T@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_9
k59_1057159_2	713586.KB900536_gene1880	3.32e-84	275.0	COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,1WWWU@135613|Chromatiales	135613|Chromatiales	C	CoA-binding domain protein	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_881345_1	472759.Nhal_3336	0.00096	48.5	COG5338@1|root,COG5338@2|Bacteria,1RH6I@1224|Proteobacteria,1SZUD@1236|Gammaproteobacteria,1WYQI@135613|Chromatiales	135613|Chromatiales	S	Putative beta-barrel porin 2	-	-	-	-	-	-	-	-	-	-	-	-	BBP2_2
k59_293893_1	331869.BAL199_18816	5.66e-80	258.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,2TRMQ@28211|Alphaproteobacteria,4BRG0@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
k59_176520_1	396588.Tgr7_2896	6.44e-95	283.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,1RMXS@1236|Gammaproteobacteria,1WW0T@135613|Chromatiales	135613|Chromatiales	E	PFAM Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
k59_176520_2	583345.Mmol_1984	1.61e-60	197.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,2VJS2@28216|Betaproteobacteria,2KKXB@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
k59_1409302_2	1123393.KB891332_gene2691	5.74e-88	270.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2VKHP@28216|Betaproteobacteria,1KSNS@119069|Hydrogenophilales	119069|Hydrogenophilales	V	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
k59_352978_1	749414.SBI_05548	1.75e-37	145.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,Trans_reg_C
k59_599_1	1267005.KB911258_gene322	1.83e-14	78.2	COG2304@1|root,COG4961@1|root,COG2304@2|Bacteria,COG4961@2|Bacteria,1MWXU@1224|Proteobacteria,2TRQP@28211|Alphaproteobacteria,3N7FF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad,VWA
k59_940072_1	243233.MCA2976	2.94e-67	209.0	COG4567@1|root,COG4567@2|Bacteria,1RD7J@1224|Proteobacteria,1S3PE@1236|Gammaproteobacteria,1XE1Z@135618|Methylococcales	135618|Methylococcales	T	response regulator	-	-	-	ko:K15012	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg
k59_940072_2	396588.Tgr7_2453	9.05e-51	175.0	COG2885@1|root,COG2885@2|Bacteria,1PGGZ@1224|Proteobacteria,1RNFU@1236|Gammaproteobacteria,1X1X5@135613|Chromatiales	135613|Chromatiales	M	OmpA family	-	-	-	ko:K21218	ko02040,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	OmpA
k59_1115829_1	545276.KB898726_gene1098	1.47e-23	97.8	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,1WWHP@135613|Chromatiales	135613|Chromatiales	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_293913_1	794903.OPIT5_02870	1.75e-61	213.0	COG1197@1|root,COG1197@2|Bacteria,46S6Y@74201|Verrucomicrobia,3K7Q7@414999|Opitutae	414999|Opitutae	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_940075_1	1380391.JIAS01000011_gene4693	4.44e-127	369.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TT67@28211|Alphaproteobacteria,2JQ57@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1292272_1	765914.ThisiDRAFT_1630	4.21e-77	241.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1WXDA@135613|Chromatiales	135613|Chromatiales	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
k59_1233252_1	1255043.TVNIR_0128	3.37e-05	46.2	COG2199@1|root,COG3706@2|Bacteria,1RCC4@1224|Proteobacteria,1S523@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_1233252_2	1279019.ARQK01000050_gene1299	3.49e-58	187.0	COG0693@1|root,COG0693@2|Bacteria,1N7T2@1224|Proteobacteria,1RSBI@1236|Gammaproteobacteria,1WY2E@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM DJ-1 family protein	-	-	3.5.1.124	ko:K03152	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
k59_1233252_3	1089447.RHAA1_00320	9.5e-33	128.0	COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,1RNKH@1236|Gammaproteobacteria,1Y7CK@135625|Pasteurellales	135625|Pasteurellales	S	Protein involved in catalytic activity, hydrolase activity acting on carbon-nitrogen (but not peptide) bonds and carbohydrate metabolic process	Z012_04400	-	-	ko:K09798	-	-	-	-	ko00000	-	-	-	Polysacc_deac_2
k59_1233252_4	395493.BegalDRAFT_1293	2.17e-111	341.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,45ZP3@72273|Thiotrichales	72273|Thiotrichales	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_1233252_5	768671.ThimaDRAFT_2565	4.04e-46	166.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1WX4I@135613|Chromatiales	135613|Chromatiales	D	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_470030_1	439235.Dalk_0513	5.26e-34	137.0	COG0664@1|root,COG1033@1|root,COG2199@1|root,COG0664@2|Bacteria,COG1033@2|Bacteria,COG2199@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria,2MJQ7@213118|Desulfobacterales	28221|Deltaproteobacteria	K	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	GGDEF,LolA_like,MMPL,cNMP_binding
k59_117861_1	1235794.C811_02196	4.22e-06	48.1	COG0085@1|root,COG0085@2|Bacteria,2GJ81@201174|Actinobacteria,4CUH0@84998|Coriobacteriia	84998|Coriobacteriia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_59488_1	351348.Maqu_1128	8.74e-35	130.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,464GH@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	histidyl-tRNA synthetase	hisS	GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358	HGTP_anticodon,tRNA-synt_His
k59_59488_2	1216007.AOPM01000027_gene3628	1.4e-08	60.1	COG1426@1|root,COG1426@2|Bacteria,1N240@1224|Proteobacteria,1RQMV@1236|Gammaproteobacteria,2Q0QS@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	rodZ	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
k59_411334_1	1249627.D779_3250	3.95e-185	525.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1WX6G@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_1526685_1	1385517.N800_15095	2.83e-36	126.0	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1X7P3@135614|Xanthomonadales	135614|Xanthomonadales	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
k59_1233257_1	1246474.ANBE01000035_gene2570	6.32e-30	122.0	COG0460@1|root,COG0460@2|Bacteria,2GIX9@201174|Actinobacteria,4EGPT@85012|Streptosporangiales	201174|Actinobacteria	E	Homoserine dehydrogenase	hom	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.1.1.3,2.7.2.4	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1294	ACT,Homoserine_dh,NAD_binding_3
k59_1350645_1	1565129.JSFF01000005_gene2300	1.1e-48	162.0	28PFD@1|root,2ZC6I@2|Bacteria,1R8PT@1224|Proteobacteria,1S49D@1236|Gammaproteobacteria,2QEH9@267890|Shewanellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1468074_1	243233.MCA2577	1.14e-81	260.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1XER5@135618|Methylococcales	1236|Gammaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.17.1.9	ko:K00122	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_528746_1	1137799.GZ78_21080	3.6e-24	100.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1XHSK@135619|Oceanospirillales	135619|Oceanospirillales	J	SAM-dependent	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
k59_528746_2	717774.Marme_0710	2.02e-72	225.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1XH7U@135619|Oceanospirillales	135619|Oceanospirillales	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_763598_1	1278309.KB907100_gene2320	7.12e-55	183.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1XH97@135619|Oceanospirillales	135619|Oceanospirillales	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_763598_2	298386.PBPRA1404	1.59e-74	238.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1XUVI@135623|Vibrionales	135623|Vibrionales	Q	COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1292301_1	396588.Tgr7_3279	4.75e-123	358.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1T02D@1236|Gammaproteobacteria,1WW5T@135613|Chromatiales	135613|Chromatiales	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_411342_1	765911.Thivi_1855	6.25e-100	317.0	COG1328@1|root,COG1372@1|root,COG1328@2|Bacteria,COG1372@2|Bacteria,1MWMS@1224|Proteobacteria,1RNHS@1236|Gammaproteobacteria,1X2DE@135613|Chromatiales	135613|Chromatiales	F	Ribonucleoside-triphosphate reductase	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,LAGLIDADG_3,NRDD
k59_1702886_1	589865.DaAHT2_1438	3.88e-08	51.6	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,42SF6@68525|delta/epsilon subdivisions,2WPDP@28221|Deltaproteobacteria,2MJZV@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
k59_1702886_2	500632.CLONEX_00944	3.66e-63	199.0	COG0097@1|root,COG0097@2|Bacteria,1V1FC@1239|Firmicutes,2496R@186801|Clostridia	186801|Clostridia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_1820666_1	331869.BAL199_21059	7.52e-36	139.0	28HD5@1|root,2Z7PV@2|Bacteria,1R46T@1224|Proteobacteria,2U0A1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Zeta_toxin
k59_1057207_1	857087.Metme_2755	9.25e-45	158.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1XDRQ@135618|Methylococcales	135618|Methylococcales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_632_1	885580.XP_010635262.1	3.98e-49	170.0	COG2220@1|root,KOG3798@2759|Eukaryota,39UP3@33154|Opisthokonta,3BFB2@33208|Metazoa,3CWR9@33213|Bilateria,47ZVI@7711|Chordata,48Z9Y@7742|Vertebrata,3J70C@40674|Mammalia,359U9@314146|Euarchontoglires,4PVUG@9989|Rodentia	33208|Metazoa	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	NAPEPLD	GO:0001523,GO:0001659,GO:0001750,GO:0003674,GO:0003824,GO:0004620,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005768,GO:0005769,GO:0005794,GO:0005829,GO:0005886,GO:0005929,GO:0006066,GO:0006576,GO:0006629,GO:0006644,GO:0006650,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007568,GO:0008081,GO:0008150,GO:0008152,GO:0008270,GO:0009308,GO:0009987,GO:0012505,GO:0016020,GO:0016101,GO:0016298,GO:0016787,GO:0016788,GO:0019637,GO:0031090,GO:0031253,GO:0031347,GO:0031349,GO:0031410,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0031982,GO:0032101,GO:0032103,GO:0032501,GO:0032502,GO:0034308,GO:0034641,GO:0035900,GO:0036477,GO:0042439,GO:0042578,GO:0042592,GO:0042622,GO:0042802,GO:0042995,GO:0043005,GO:0043025,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043603,GO:0044106,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044297,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044441,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0045595,GO:0045597,GO:0045598,GO:0045600,GO:0046337,GO:0046486,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048521,GO:0048522,GO:0048583,GO:0048584,GO:0048871,GO:0050727,GO:0050729,GO:0050789,GO:0050793,GO:0050794,GO:0050795,GO:0050896,GO:0051094,GO:0060170,GO:0060259,GO:0065007,GO:0065008,GO:0070013,GO:0070290,GO:0070291,GO:0070292,GO:0071704,GO:0071944,GO:0080134,GO:0090335,GO:0090336,GO:0097458,GO:0097708,GO:0097730,GO:0097731,GO:0097733,GO:0098588,GO:0098590,GO:0120025,GO:0120038,GO:1901564,GO:1901615,GO:1903998,GO:1903999,GO:2000252	3.1.4.54	ko:K13985	ko04723,map04723	-	-	-	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
k59_1644236_1	1121434.AULY01000007_gene1302	9.21e-70	225.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,42QZ9@68525|delta/epsilon subdivisions,2X5HU@28221|Deltaproteobacteria,2MGRB@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Aminotransferase class-III	-	-	2.6.1.77	ko:K03851	ko00430,ko01100,map00430,map01100	-	R05652	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_411347_1	713587.THITH_08470	8.7e-124	371.0	COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,1WXBQ@135613|Chromatiales	135613|Chromatiales	O	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_587482_1	187272.Mlg_0458	2.09e-103	304.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,1RMK9@1236|Gammaproteobacteria,1WVZS@135613|Chromatiales	135613|Chromatiales	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_587482_2	1122197.ATWI01000013_gene2376	3.01e-11	62.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,464IZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Forms part of the polypeptide exit tunnel	rplD	GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003700,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008428,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030234,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032069,GO:0032074,GO:0032268,GO:0032269,GO:0032991,GO:0032993,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065003,GO:0065007,GO:0065009,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:0098772,GO:0140110,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990904,GO:2000112,GO:2000113,GO:2001141	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_353050_1	933262.AXAM01000030_gene800	1.16e-90	281.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,42MYA@68525|delta/epsilon subdivisions,2WKFB@28221|Deltaproteobacteria,2MIHP@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM Pyridoxal-dependent decarboxylase	-	-	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	EF-hand_7,Pyridoxal_deC
k59_940137_2	670292.JH26_00425	1.27e-76	237.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,1JTSW@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_1174559_1	187272.Mlg_0570	2.76e-56	190.0	COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1WX8Q@135613|Chromatiales	135613|Chromatiales	M	Cell wall hydrolase autolysin	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,LysM
k59_941573_1	1123065.ATWL01000008_gene2426	4.43e-24	98.6	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria	201174|Actinobacteria	G	inositol monophosphatase	hisN	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15,3.1.3.25	ko:K01092,ko:K05602	ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00131	R01185,R01186,R01187,R03013	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_60954_1	1348114.OM33_02685	5.26e-97	303.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria,2Q0FW@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	KT	COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K11914	-	-	-	-	ko00000,ko02044,ko03000	-	-	-	HTH_8,PAS,PAS_9,Sigma54_activat
k59_705855_1	349521.HCH_02652	4.43e-17	88.2	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1XJ2I@135619|Oceanospirillales	135619|Oceanospirillales	U	Type II secretory pathway, component ExeA	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22
k59_470943_1	1163409.UUA_10521	1.02e-50	177.0	COG0596@1|root,COG0596@2|Bacteria,1R6KU@1224|Proteobacteria,1RNTQ@1236|Gammaproteobacteria,1X2Y2@135614|Xanthomonadales	135614|Xanthomonadales	I	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
k59_294839_1	768671.ThimaDRAFT_1585	8.28e-69	218.0	COG2378@1|root,COG2378@2|Bacteria,1P2ZE@1224|Proteobacteria,1RYHJ@1236|Gammaproteobacteria,1WXZG@135613|Chromatiales	135613|Chromatiales	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
k59_705858_1	498761.HM1_2656	5.7e-06	45.8	COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,24QK9@186801|Clostridia	186801|Clostridia	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
k59_705860_1	1121481.AUAS01000001_gene4742	2.31e-08	59.7	COG1309@1|root,COG1309@2|Bacteria,4NM8G@976|Bacteroidetes,47MK9@768503|Cytophagia	976|Bacteroidetes	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_13,TetR_N
k59_1813_1	396588.Tgr7_0328	1.28e-72	226.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RMJU@1236|Gammaproteobacteria,1WXHM@135613|Chromatiales	135613|Chromatiales	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
k59_294843_1	640512.BC1003_0664	6.13e-120	360.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VZNG@28216|Betaproteobacteria,1K6IW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	similarity to GP 3192745	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_236406_1	1304865.JAGF01000001_gene1666	1.48e-166	482.0	COG1018@1|root,COG1018@2|Bacteria,2HE37@201174|Actinobacteria	201174|Actinobacteria	C	Ferric reductase domain protein transmembrane component	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Ferric_reduct,NAD_binding_1
k59_1762395_1	2340.JV46_15480	2.63e-43	143.0	COG2168@1|root,COG2168@2|Bacteria	2|Bacteria	P	tRNA wobble position uridine thiolation	tusB	GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234	-	ko:K07237	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DsrH
k59_1762395_2	2340.JV46_15490	1.05e-13	66.6	COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,1SD0S@1236|Gammaproteobacteria,1J7BW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the DsrF TusC family	tusC	GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234	-	ko:K07236	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DrsE
k59_882903_1	1095767.CAHD01000238_gene1799	1.73e-109	327.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria,4F0GG@85016|Cellulomonadaceae	201174|Actinobacteria	NU	PFAM Type II secretion system F domain	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
k59_882903_2	1125718.HMPREF1318_1904	3.46e-14	71.2	COG4965@1|root,COG4965@2|Bacteria,2I3KW@201174|Actinobacteria,4D3YB@85005|Actinomycetales	201174|Actinobacteria	U	Type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
k59_294853_1	1121438.JNJA01000006_gene226	5.59e-15	76.3	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,42TVX@68525|delta/epsilon subdivisions,2WP4F@28221|Deltaproteobacteria,2MCJ6@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Lytic transglycosylase catalytic	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	DUF4124,SLT
k59_354480_1	1454004.AW11_02007	9.5e-83	272.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KQ5Y@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	V	MMPL family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1293779_1	203122.Sde_2082	4e-12	73.6	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,4646P@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	COG3170 Tfp pilus assembly protein FimV	fimV	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	LysM,TPR_19
k59_1293779_2	1348657.M622_08570	5.41e-05	47.0	COG0619@1|root,COG0619@2|Bacteria,1N7EI@1224|Proteobacteria,2VWJT@28216|Betaproteobacteria,2KX6B@206389|Rhodocyclales	206389|Rhodocyclales	P	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	-	-	-	-	-	-	-	-	-	-	-	-	CbiQ
k59_1833_1	1280941.HY2_14375	4.91e-06	50.1	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2TQZG@28211|Alphaproteobacteria,43WQU@69657|Hyphomonadaceae	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100,1.1.1.401	ko:K00059,ko:K21883	ko00051,ko00061,ko00333,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,map00051,map00061,map00333,map00780,map01040,map01100,map01120,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11339,R11671	RC00029,RC00089,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1175490_1	215803.DB30_8138	3.26e-100	304.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2YZJI@29|Myxococcales	28221|Deltaproteobacteria	H	S-adenosyl-L-homocysteine hydrolase, NAD binding domain	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_61001_1	187272.Mlg_0413	9.11e-84	262.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1WWPA@135613|Chromatiales	135613|Chromatiales	S	modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_354487_2	1151122.AQYD01000007_gene501	3.88e-53	171.0	COG0315@1|root,COG0315@2|Bacteria,2IHR6@201174|Actinobacteria,4FNWJ@85023|Microbacteriaceae	201174|Actinobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
k59_1762407_1	279714.FuraDRAFT_0998	2.68e-41	148.0	COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,2VR9X@28216|Betaproteobacteria	28216|Betaproteobacteria	K	transcriptional regulator AsnC family	nirH	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
k59_941628_1	1454004.AW11_01349	4.67e-33	131.0	COG2911@1|root,COG3210@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,1P8N9@1224|Proteobacteria,2VMKU@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_177501_1	1304865.JAGF01000001_gene754	9.62e-98	307.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria,4F0E3@85016|Cellulomonadaceae	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1822094_1	880072.Desac_1131	1.28e-114	350.0	COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria,42NE4@68525|delta/epsilon subdivisions,2WJX6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,sCache_3_2
k59_412260_1	996637.SGM_5655	2.34e-58	204.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2GN09@201174|Actinobacteria	201174|Actinobacteria	E	Glutamate synthase	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_882934_1	1120954.ATXE01000001_gene2289	8.05e-13	71.2	COG1595@1|root,COG1595@2|Bacteria,2GK4C@201174|Actinobacteria,4DQEU@85009|Propionibacteriales	201174|Actinobacteria	K	Sigma-70, region 4	sigE	GO:0000302,GO:0000988,GO:0000990,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0043207,GO:0043254,GO:0044087,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0090034,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_118846_1	935839.JAGJ01000017_gene208	3.48e-48	161.0	2AN86@1|root,31D67@2|Bacteria,2HWWU@201174|Actinobacteria,4F4DC@85017|Promicromonosporaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3043)	-	GO:0008150,GO:0009605,GO:0009607,GO:0020012,GO:0030682,GO:0042783,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136	-	-	-	-	-	-	-	-	-	-	DUF3043
k59_118846_3	593907.Celgi_1403	3.1e-130	381.0	COG0167@1|root,COG0167@2|Bacteria,2GKC6@201174|Actinobacteria,4F0F3@85016|Cellulomonadaceae	201174|Actinobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.3.5.2,1.3.98.1	ko:K00226,ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01867,R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_941646_1	78898.MVEG_09370T0	0.000944	46.6	COG0484@1|root,KOG0715@2759|Eukaryota,38H0N@33154|Opisthokonta,3NUEY@4751|Fungi,1GVDX@112252|Fungi incertae sedis	4751|Fungi	O	DnaJ C terminal domain	MDJ1	GO:0000002,GO:0001671,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0005829,GO:0006457,GO:0006458,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006996,GO:0007005,GO:0008047,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016020,GO:0016043,GO:0019538,GO:0019866,GO:0019898,GO:0030163,GO:0030234,GO:0030544,GO:0031072,GO:0031090,GO:0031312,GO:0031314,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032781,GO:0042026,GO:0043085,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043462,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051336,GO:0051345,GO:0051603,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0071840,GO:0098772,GO:1901564,GO:1901565,GO:1901575	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_470994_1	326297.Sama_3087	1.41e-58	188.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,2Q8NC@267890|Shewanellaceae	1236|Gammaproteobacteria	S	PFAM ABC transporter related	lptB	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
k59_412270_1	367299.JOEE01000007_gene204	5.65e-18	79.3	COG5516@1|root,COG5516@2|Bacteria,2GNZF@201174|Actinobacteria,4FGX9@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative stress-induced transcription regulator	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
k59_412270_2	367299.JOEE01000007_gene203	4.55e-50	168.0	COG0697@1|root,COG0697@2|Bacteria,2GKVT@201174|Actinobacteria,4FF7Q@85021|Intrasporangiaceae	201174|Actinobacteria	EG	EamA-like transporter family	ydeD	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_647193_1	1120917.AQXM01000050_gene1038	5.14e-61	209.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,1W7N0@1268|Micrococcaceae	201174|Actinobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	ctpE	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	-	ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.23	-	-	E1-E2_ATPase,Hydrolase
k59_1234221_1	153948.NAL212_3117	5.72e-117	367.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2VJSI@28216|Betaproteobacteria,372PZ@32003|Nitrosomonadales	28216|Betaproteobacteria	L	RNA polymerase recycling family C-terminal	-	-	-	ko:K03580	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	DUF3883,Helicase_C,RapA_C,ResIII,SNF2_N
k59_476668_1	1379270.AUXF01000001_gene2572	2.23e-07	57.8	COG0589@1|root,COG0589@2|Bacteria,1ZUMR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_476668_2	292415.Tbd_1380	3.18e-46	155.0	COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,2VJ4W@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Hydrogenase expression formation protein	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
k59_417799_1	367299.JOEE01000005_gene3584	1.83e-124	368.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,4FFXT@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_69234_1	523791.Kkor_0387	1.27e-71	231.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1XHE8@135619|Oceanospirillales	135619|Oceanospirillales	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.32,1.2.1.60,1.2.1.8,1.2.1.85	ko:K00130,ko:K00151,ko:K10217	ko00260,ko00350,ko00362,ko00380,ko00622,ko01100,ko01120,ko01220,map00260,map00350,map00362,map00380,map00622,map01100,map01120,map01220	M00038,M00533,M00555,M00569	R02565,R02566,R02762,R03889,R04418,R05353	RC00080,RC00218,RC00254	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_12547_1	1238450.VIBNISOn1_1010019	0.000421	42.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1XT9F@135623|Vibrionales	135623|Vibrionales	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_12547_2	996637.SGM_5572	1.56e-35	132.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	drrA_2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1066452_1	1448139.AI20_09975	1.47e-15	75.9	COG0705@1|root,COG0705@2|Bacteria,1N8NS@1224|Proteobacteria,1SD4M@1236|Gammaproteobacteria,1Y4Y9@135624|Aeromonadales	135624|Aeromonadales	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
k59_1066452_2	1200567.JNKD01000002_gene2250	7.28e-10	58.2	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,1Y4JA@135624|Aeromonadales	135624|Aeromonadales	U	general secretion pathway protein G	exeG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
k59_1831278_1	1173024.KI912151_gene2457	1.39e-55	197.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1JJJW@1189|Stigonemataceae	1117|Cyanobacteria	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
k59_769760_2	1328313.DS2_11863	1.85e-05	46.2	2BWPY@1|root,2Z8BI@2|Bacteria,1QHHB@1224|Proteobacteria,1RP8D@1236|Gammaproteobacteria,4657P@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1241991_1	441620.Mpop_3289	1.35e-19	93.2	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2TQKJ@28211|Alphaproteobacteria,1JS9W@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_712439_1	1123073.KB899242_gene974	0.000641	47.4	COG1426@1|root,COG1426@2|Bacteria,1N240@1224|Proteobacteria,1RQMV@1236|Gammaproteobacteria,1X5X4@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
k59_712439_2	1045856.EcWSU1_03330	1.7e-36	134.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,3X1HI@547|Enterobacter	1236|Gammaproteobacteria	J	histidyl-tRNA synthetase	hisS	GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358	HGTP_anticodon,tRNA-synt_His
k59_1533858_1	314285.KT71_02502	1.8e-54	179.0	COG4798@1|root,COG4798@2|Bacteria,1NNHX@1224|Proteobacteria,1RN1A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_184112_1	644107.SL1157_1137	2.15e-94	283.0	COG0715@1|root,COG0715@2|Bacteria,1MVRA@1224|Proteobacteria,2TQPE@28211|Alphaproteobacteria,4NB7D@97050|Ruegeria	28211|Alphaproteobacteria	P	NMT1/THI5 like	-	-	-	ko:K15598	ko02010,map02010	M00442	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.17.3,3.A.1.17.6	-	-	NMT1
k59_1066491_1	257310.BB3420	5.41e-40	151.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,3T39S@506|Alcaligenaceae	28216|Betaproteobacteria	Q	ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_769771_1	1122134.KB893650_gene859	4.62e-160	468.0	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,1RNS0@1236|Gammaproteobacteria,1XICD@135619|Oceanospirillales	135619|Oceanospirillales	C	Cytochrome D1 heme domain	-	-	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_1592278_1	471853.Bcav_1187	8.31e-107	321.0	COG0579@1|root,COG0579@2|Bacteria,2GKFB@201174|Actinobacteria	201174|Actinobacteria	S	FAD dependent oxidoreductase	-	-	-	ko:K15736	-	-	-	-	ko00000,ko01000	-	-	-	DAO
k59_1357918_1	933262.AXAM01000002_gene515	3.67e-45	156.0	COG4822@1|root,COG4822@2|Bacteria,1P36Y@1224|Proteobacteria,42P9C@68525|delta/epsilon subdivisions,2WK8C@28221|Deltaproteobacteria,2MIFS@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the insertion of Co(2 ) into sirohydrochlorin	cbiKp	GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0009987,GO:0016043,GO:0016829,GO:0016852,GO:0020037,GO:0022607,GO:0042597,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050897,GO:0051259,GO:0051262,GO:0051266,GO:0065003,GO:0071840,GO:0097159,GO:1901363	4.99.1.3	ko:K02190	ko00860,ko01100,map00860,map01100	-	R05807	RC01012	ko00000,ko00001,ko01000	-	-	-	CbiK
k59_891976_1	768671.ThimaDRAFT_3686	1.07e-34	124.0	2E0F6@1|root,32W1G@2|Bacteria,1N6I3@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_829622_1	886293.Sinac_4620	5.67e-41	154.0	COG0467@1|root,COG1112@1|root,COG3827@1|root,COG0467@2|Bacteria,COG1112@2|Bacteria,COG3827@2|Bacteria,2IX3V@203682|Planctomycetes	203682|Planctomycetes	L	Protein of unknown function (DUF4011)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DUF3320,DUF4011
k59_1303172_1	765912.Thimo_2185	1.11e-58	189.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,1RNV4@1236|Gammaproteobacteria,1WX0I@135613|Chromatiales	135613|Chromatiales	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
k59_184127_1	794846.AJQU01000028_gene17	0.000133	49.7	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,4B8YI@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K21134	-	M00821	-	-	ko00000,ko00002,ko02000	2.A.6.2.27	-	-	ACR_tran
k59_184130_1	1121364.ATVG01000012_gene1572	3.1e-15	77.0	COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,22JWU@1653|Corynebacteriaceae	201174|Actinobacteria	K	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	glxR	GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_1417189_1	1384056.N787_08600	2.22e-70	228.0	COG2978@1|root,COG2978@2|Bacteria,1MUJ1@1224|Proteobacteria,1RMAI@1236|Gammaproteobacteria,1X5D5@135614|Xanthomonadales	135614|Xanthomonadales	H	AbgT putative transporter family	-	-	-	-	-	-	-	-	-	-	-	-	ABG_transport
k59_712458_1	1249627.D779_3818	2.1e-92	281.0	COG3001@1|root,COG3001@2|Bacteria,1MVHX@1224|Proteobacteria,1RRC5@1236|Gammaproteobacteria,1WXE3@135613|Chromatiales	135613|Chromatiales	G	PFAM Fructosamine	-	-	-	-	-	-	-	-	-	-	-	-	Fructosamin_kin
k59_712458_2	1205753.A989_18963	3.57e-89	275.0	COG0258@1|root,COG0258@2|Bacteria,1RAAR@1224|Proteobacteria,1RN1S@1236|Gammaproteobacteria,1X448@135614|Xanthomonadales	135614|Xanthomonadales	L	Exodeoxyribonuclease IX	exo	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
k59_1651998_1	880072.Desac_1623	4.37e-172	488.0	COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,42MRB@68525|delta/epsilon subdivisions,2WIZD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM sulfite reductase, dissimilatory-type alpha subunit	dsrA	-	1.8.99.5	ko:K11180	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_712460_1	1156935.QWE_15908	3.83e-65	216.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2TRU8@28211|Alphaproteobacteria,4B84G@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF853)	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
k59_12629_1	977880.RALTA_B1753	4.17e-06	54.3	COG3408@1|root,COG3408@2|Bacteria,1MUYU@1224|Proteobacteria,2VIMW@28216|Betaproteobacteria,1K1QU@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Amylo-alpha-1,6-glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
k59_1303194_1	330084.JNYZ01000037_gene8030	3.16e-28	114.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_1122099_1	1095767.CAHD01000115_gene56	8.85e-09	56.2	COG0494@1|root,COG0494@2|Bacteria,2GNRV@201174|Actinobacteria,4F0EQ@85016|Cellulomonadaceae	201174|Actinobacteria	L	Phosphoglycerate mutase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1,NUDIX
k59_1122099_2	33898.JRHJ01000005_gene3704	9.82e-68	227.0	COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria	201174|Actinobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_363780_1	443906.CMM_2195	1.89e-36	138.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,2GJ11@201174|Actinobacteria,4FMZ0@85023|Microbacteriaceae	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
k59_363780_2	512565.AMIS_46730	3.86e-42	142.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,4DESS@85008|Micromonosporales	201174|Actinobacteria	E	Glycine cleavage H-protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
k59_1592296_1	631362.Thi970DRAFT_04513	1.52e-120	380.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1WWGW@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM ATP-dependent helicase HrpA	-	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_1066546_1	396588.Tgr7_1833	2.02e-43	152.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1WWGC@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1357935_1	1125863.JAFN01000001_gene3444	2.28e-102	307.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42Q41@68525|delta/epsilon subdivisions,2WK4A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_594792_1	1197906.CAJQ02000033_gene2110	9.95e-09	62.0	COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,2TRBC@28211|Alphaproteobacteria,3JSHY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Beta-lactamase superfamily domain	romA	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_1592299_1	859657.RPSI07_0732	5.45e-29	112.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2VHHC@28216|Betaproteobacteria,1K1AJ@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004764,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046417,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0055114,GO:0061458,GO:0071704,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
k59_1592299_2	7209.EFO27373.2	8.75e-17	79.0	COG1249@1|root,KOG0405@2759|Eukaryota,39J8D@33154|Opisthokonta,3BDB0@33208|Metazoa,3D06N@33213|Bilateria,40BWU@6231|Nematoda,1KUKW@119089|Chromadorea	33208|Metazoa	Q	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	GSR	GO:0000003,GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0002931,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0006091,GO:0006139,GO:0006518,GO:0006575,GO:0006725,GO:0006749,GO:0006790,GO:0006807,GO:0006950,GO:0006979,GO:0007276,GO:0007283,GO:0007568,GO:0007584,GO:0008150,GO:0008152,GO:0009055,GO:0009605,GO:0009636,GO:0009897,GO:0009986,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0014823,GO:0015036,GO:0015037,GO:0015038,GO:0015949,GO:0016020,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018996,GO:0019953,GO:0022404,GO:0022414,GO:0022900,GO:0031667,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0033189,GO:0033218,GO:0033273,GO:0033554,GO:0033993,GO:0034599,GO:0034641,GO:0035094,GO:0036094,GO:0042221,GO:0042277,GO:0042303,GO:0042395,GO:0042493,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043295,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044703,GO:0045471,GO:0046483,GO:0046677,GO:0046686,GO:0046983,GO:0048037,GO:0048232,GO:0048609,GO:0050660,GO:0050661,GO:0050662,GO:0050896,GO:0051186,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0070013,GO:0070887,GO:0071704,GO:0071944,GO:0072341,GO:0097159,GO:0097237,GO:0097305,GO:0098552,GO:0098622,GO:0098754,GO:0098869,GO:1900750,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901681,GO:1901700,GO:1990748	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_125419_1	399795.CtesDRAFT_PD3115	2.91e-24	102.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria,4ABGB@80864|Comamonadaceae	28216|Betaproteobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
k59_125419_2	990285.RGCCGE502_08870	1.11e-48	160.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2U956@28211|Alphaproteobacteria,4BDZT@82115|Rhizobiaceae	28211|Alphaproteobacteria	FG	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
k59_712474_1	1037409.BJ6T_65090	3.86e-85	266.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
k59_951030_1	1479235.KK366039_gene860	4.2e-96	304.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1XIHW@135619|Oceanospirillales	135619|Oceanospirillales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,zf-C4_Topoisom
k59_70330_1	717785.HYPMC_4048	3.21e-24	99.8	COG1586@1|root,COG1586@2|Bacteria	2|Bacteria	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speD	-	2.5.1.16,4.1.1.50	ko:K00797,ko:K01611	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R00178,R01920,R02869,R08359	RC00021,RC00053,RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc,Spermine_synth
k59_712477_2	768066.HELO_2212	5.43e-74	239.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,1XP8V@135619|Oceanospirillales	135619|Oceanospirillales	S	ErfK YbiS YcfS YnhG	-	-	-	ko:K16291	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	YkuD
k59_1592310_1	631362.Thi970DRAFT_03306	2.53e-238	679.0	COG0438@1|root,COG0438@2|Bacteria,1QZ01@1224|Proteobacteria,1RZJA@1236|Gammaproteobacteria,1X05E@135613|Chromatiales	135613|Chromatiales	M	sucrose synthase	-	-	2.4.1.13	ko:K00695	ko00500,ko01100,map00500,map01100	-	R00806	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glycos_transf_1,Sucrose_synth
k59_1122124_1	768671.ThimaDRAFT_2152	9.98e-59	197.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1WW2V@135613|Chromatiales	135613|Chromatiales	M	zinc metalloprotease	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_1592312_2	1304865.JAGF01000001_gene3278	3.07e-112	347.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,2H7WY@201174|Actinobacteria,4F10M@85016|Cellulomonadaceae	201174|Actinobacteria	P	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	cdr	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
k59_12693_1	414684.RC1_2513	1.99e-103	311.0	COG2204@1|root,COG2204@2|Bacteria,1MWW5@1224|Proteobacteria,2TXAZ@28211|Alphaproteobacteria,2JQAG@204441|Rhodospirillales	204441|Rhodospirillales	K	Sigma-54 interaction domain	-	-	-	ko:K03974	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,Sigma54_activat
k59_536329_1	1238182.C882_2551	1.37e-40	149.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2TSGT@28211|Alphaproteobacteria,2JPJT@204441|Rhodospirillales	204441|Rhodospirillales	E	acetylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_829681_1	1121381.JNIV01000036_gene3361	6.9e-07	55.1	28JEU@1|root,2Z98W@2|Bacteria	2|Bacteria	S	PFAM MULE transposase, conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	MULE,Transposase_mut
k59_594826_1	879212.DespoDRAFT_01980	8.91e-18	84.3	COG1230@1|root,COG2259@1|root,COG1230@2|Bacteria,COG2259@2|Bacteria,1MVQB@1224|Proteobacteria,42MJ0@68525|delta/epsilon subdivisions,2WMDZ@28221|Deltaproteobacteria,2MIR0@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Cation efflux family	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
k59_1066625_1	1343739.PAP_09095	4.31e-37	138.0	COG0366@1|root,arCOG03430@1|root,arCOG02948@2157|Archaea,arCOG03430@2157|Archaea,2XUE6@28890|Euryarchaeota	28890|Euryarchaeota	G	Alpha amylase	malA	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Alpha-amylase_C,DUF3459
k59_536336_1	1120999.JONM01000013_gene2120	3.44e-06	52.4	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_184190_1	935548.KI912159_gene5487	4.9e-33	128.0	COG2710@1|root,COG2710@2|Bacteria,1MUGI@1224|Proteobacteria,2TU7U@28211|Alphaproteobacteria,43MSD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Nitrogenase component 1 type Oxidoreductase	bchY	-	1.3.7.14,1.3.7.15	ko:K11334	ko00860,ko01110,map00860,map01110	-	R09053,R09060	RC01008	ko00000,ko00001,ko01000	-	-	-	Oxidored_nitro
k59_184190_2	414684.RC1_2094	4.12e-106	315.0	COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,2TSKC@28211|Alphaproteobacteria,2JQA6@204441|Rhodospirillales	204441|Rhodospirillales	P	Belongs to the NifH BchL ChlL family	bchX	-	1.3.7.14,1.3.7.15	ko:K11333	ko00860,ko01110,map00860,map01110	-	R09053,R09060	RC01008	ko00000,ko00001,ko01000	-	-	-	Fer4_NifH
k59_1592324_1	765910.MARPU_08435	3.97e-59	200.0	COG3746@1|root,COG3746@2|Bacteria,1MY3M@1224|Proteobacteria,1RZ3M@1236|Gammaproteobacteria,1WWSF@135613|Chromatiales	135613|Chromatiales	P	phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	TonB_dep_Rec
k59_653793_1	1304865.JAGF01000001_gene3189	2.55e-109	352.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,2GM5R@201174|Actinobacteria,4F0HK@85016|Cellulomonadaceae	201174|Actinobacteria	CE	Belongs to the aldehyde dehydrogenase family	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh
k59_70376_1	439235.Dalk_5069	2.98e-49	162.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,42RCD@68525|delta/epsilon subdivisions,2WMUP@28221|Deltaproteobacteria,2MPV5@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	bamG	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_1710037_1	429009.Adeg_1532	5.6e-64	219.0	COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,247J1@186801|Clostridia,42ETP@68295|Thermoanaerobacterales	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_892081_1	1168034.FH5T_20565	4.22e-62	214.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,2FPGA@200643|Bacteroidia	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_1242134_1	335543.Sfum_1176	2.12e-111	330.0	COG0247@1|root,COG0247@2|Bacteria,1R8YC@1224|Proteobacteria,42NJW@68525|delta/epsilon subdivisions,2WIX1@28221|Deltaproteobacteria,2MR23@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_477514_1	367299.JOEE01000008_gene574	3.53e-96	291.0	COG2265@1|root,COG2265@2|Bacteria,2GP90@201174|Actinobacteria,4FFMI@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumB	-	2.1.1.189	ko:K03212	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	tRNA_U5-meth_tr
k59_1710040_1	1173025.GEI7407_2121	3.94e-90	278.0	COG1902@1|root,COG1902@2|Bacteria,1FZYT@1117|Cyanobacteria,1H861@1150|Oscillatoriales	1117|Cyanobacteria	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
k59_1477142_1	1038859.AXAU01000030_gene6762	1.76e-91	281.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,3JVHX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1303287_1	339670.Bamb_2654	1.05e-15	79.7	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,1K004@119060|Burkholderiaceae	28216|Betaproteobacteria	M	RND efflux system, outer membrane lipoprotein, NodT family	oprM	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
k59_536354_2	1384056.N787_12995	5.94e-37	126.0	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,1X7EI@135614|Xanthomonadales	135614|Xanthomonadales	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
k59_536354_3	1268239.PALB_36450	4.39e-06	45.4	COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,2Q3DD@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	J	Belongs to the universal ribosomal protein uL29 family	rpmC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
k59_1303292_1	1713.JOFV01000001_gene1982	6.33e-147	428.0	COG0380@1|root,COG0380@2|Bacteria,2GMX7@201174|Actinobacteria,4F0SW@85016|Cellulomonadaceae	201174|Actinobacteria	G	PFAM glycosyl transferase family 20	otsA	GO:0003674,GO:0003824,GO:0003825,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0030312,GO:0033554,GO:0034637,GO:0035251,GO:0040007,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0046872,GO:0046914,GO:0047260,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:0071944,GO:1901576	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,Trehalose_PPase
k59_1831434_1	1111728.ATYS01000025_gene4245	6.2e-61	203.0	COG0074@1|root,COG0074@2|Bacteria,1MX67@1224|Proteobacteria,1RQEG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Protein of unknown function (DUF1116)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1116
k59_1182246_1	471853.Bcav_0907	6.66e-10	65.9	2C8R0@1|root,32RMN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_247810_1	1254432.SCE1572_17685	4.01e-26	112.0	COG0515@1|root,COG2203@1|root,COG3829@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YI@28221|Deltaproteobacteria,2YTVN@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory protein, Fis family	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Pkinase,PocR,Sigma54_activat
k59_1769090_1	498211.CJA_1911	1.06e-84	281.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1FGBQ@10|Cellvibrio	1236|Gammaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_1005378_1	861299.J421_5626	9.63e-81	262.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
k59_478180_1	1123256.KB907950_gene3183	3.47e-67	229.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1X4MI@135614|Xanthomonadales	135614|Xanthomonadales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_1714263_1	2423.NA23_0211065	1.33e-110	332.0	COG2403@1|root,COG2403@2|Bacteria,2GCJ5@200918|Thermotogae	200918|Thermotogae	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1421951_2	391624.OIHEL45_05475	4.13e-21	92.8	COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2TRM2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0665 Glycine D-amino acid oxidases (deaminating)	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
k59_1538338_1	512565.AMIS_27760	1.41e-61	194.0	COG2343@1|root,COG2343@2|Bacteria,2IKUM@201174|Actinobacteria,4DEEM@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
k59_1538338_2	869210.Marky_0994	7.18e-40	146.0	COG2128@1|root,COG2128@2|Bacteria,1WJ8T@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Protein of unknown function (DUF3179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3179
k59_717165_1	1249627.D779_4175	5.41e-20	94.4	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales	135613|Chromatiales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_1362378_1	713586.KB900536_gene3092	1.35e-52	189.0	COG1629@1|root,COG4771@2|Bacteria,1MX42@1224|Proteobacteria,1RQ2K@1236|Gammaproteobacteria,1WWEW@135613|Chromatiales	135613|Chromatiales	P	TonB-dependent heme hemoglobin receptor	-	-	-	ko:K16087	-	-	-	-	ko00000,ko02000	1.B.14.2	-	-	Plug,TonB_dep_Rec
k59_21033_1	580332.Slit_0904	5.3e-74	238.0	COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,2VJNA@28216|Betaproteobacteria,44W97@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Nitrogenase component 1 type Oxidoreductase	nifN	-	-	ko:K02592	-	-	-	-	ko00000	-	-	-	Oxidored_nitro
k59_423186_1	768671.ThimaDRAFT_3830	3.01e-81	251.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RQ04@1236|Gammaproteobacteria,1WXUZ@135613|Chromatiales	135613|Chromatiales	U	Part of a membrane complex involved in electron transport	-	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
k59_599058_1	1123360.thalar_03255	0.000174	51.2	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2TRW2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_834338_1	768671.ThimaDRAFT_4647	3.2e-88	285.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1WWJI@135613|Chromatiales	135613|Chromatiales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_305746_1	1123261.AXDW01000001_gene1445	1.45e-88	268.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1X2X9@135614|Xanthomonadales	135614|Xanthomonadales	V	Part of the ABC transporter complex LolCDE involved in the translocation of	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
k59_305746_2	1120953.AUBH01000001_gene1241	3.48e-17	80.1	COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,1S682@1236|Gammaproteobacteria,467DJ@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	TLL0138	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
k59_1837768_1	365044.Pnap_0123	2.14e-76	241.0	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2VHUQ@28216|Betaproteobacteria,4AAAA@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM FAD linked oxidase domain protein	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1837768_2	519989.ECTPHS_05430	2.5e-34	129.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WWEY@135613|Chromatiales	135613|Chromatiales	C	FAD linked oxidase	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_370115_1	373903.Hore_06130	6.73e-16	76.6	COG0757@1|root,COG0757@2|Bacteria,1V6E8@1239|Firmicutes,24JBK@186801|Clostridia,3WBRR@53433|Halanaerobiales	186801|Clostridia	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
k59_370115_2	1276756.AUEX01000011_gene1333	1.82e-09	55.8	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2WEXA@28216|Betaproteobacteria,4A9KB@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1309522_1	883.DvMF_0040	0.000174	45.4	COG1463@1|root,COG1463@2|Bacteria,1Q6ZU@1224|Proteobacteria,42RZ3@68525|delta/epsilon subdivisions,2WNF0@28221|Deltaproteobacteria,2M8JA@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_1309522_2	247634.GPB2148_2959	1.89e-16	81.6	COG3009@1|root,COG3009@2|Bacteria,1PDJX@1224|Proteobacteria,1TAM8@1236|Gammaproteobacteria,1JBA0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K09857	-	-	-	-	ko00000	-	-	-	ABC_trans_aux
k59_717189_1	96561.Dole_0377	1.94e-28	114.0	COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria	1224|Proteobacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
k59_834340_1	1134912.AJTV01000072_gene4072	1.94e-89	273.0	COG3335@1|root,COG3335@2|Bacteria,1MXYQ@1224|Proteobacteria,2TSX4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_423189_1	1210046.B277_10511	2.39e-23	89.4	COG0227@1|root,COG0227@2|Bacteria,2GQNU@201174|Actinobacteria,4FHCB@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
k59_423189_2	367299.JOEE01000004_gene1142	1.88e-148	437.0	COG1461@1|root,COG1461@2|Bacteria,2GKII@201174|Actinobacteria,4FFN9@85021|Intrasporangiaceae	201174|Actinobacteria	S	Dihydroxyacetone kinase	dak3	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
k59_1714297_1	211165.AJLN01000116_gene3005	5.65e-33	129.0	COG3016@1|root,COG3016@2|Bacteria,1G1JQ@1117|Cyanobacteria,1JHFW@1189|Stigonemataceae	1117|Cyanobacteria	S	Haem-binding uptake, Tiki superfamily, ChaN	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg
k59_1362404_1	469381.Dpep_0780	6.13e-24	96.7	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,3TCDC@508458|Synergistetes	508458|Synergistetes	L	PFAM transposase IS3 IS911 family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1362404_2	1137799.GZ78_14485	1.92e-114	337.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,1RXYF@1236|Gammaproteobacteria,1XHWD@135619|Oceanospirillales	135619|Oceanospirillales	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_1483626_1	387093.SUN_0487	5.55e-31	111.0	COG0721@1|root,COG0721@2|Bacteria,1Q61J@1224|Proteobacteria,42VIQ@68525|delta/epsilon subdivisions,2YQAY@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
k59_1483626_2	1165841.SULAR_09024	4.06e-23	90.9	COG4802@1|root,COG4802@2|Bacteria,1QYD3@1224|Proteobacteria,42PN1@68525|delta/epsilon subdivisions,2YMYE@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	CP	PFAM Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B,Rhodanese
k59_834347_1	1122138.AQUZ01000019_gene8163	2.07e-57	187.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4DQD4@85009|Propionibacteriales	201174|Actinobacteria	E	Amino acid amide ABC transporter ATP-binding protein 2, HAAT family	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_76601_2	1121296.JONJ01000001_gene1778	2.04e-09	57.8	COG3404@1|root,COG3404@2|Bacteria,1V1X8@1239|Firmicutes,24JZM@186801|Clostridia,223XR@1506553|Lachnoclostridium	186801|Clostridia	E	Formiminotransferase-cyclodeaminase	fchA	-	4.3.1.4	ko:K01746	ko00670,ko01100,map00670,map01100	-	R02302	RC00688	ko00000,ko00001,ko01000	-	-	-	FTCD_C
k59_1772778_1	717785.HYPMC_4175	3.6e-179	541.0	COG3087@1|root,COG5001@1|root,COG3087@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3N644@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC	MA20_18100	-	3.1.4.52	ko:K13245	ko04112,map04112	-	R08991	RC00296	ko00000,ko00001,ko01000	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,EAL,GGDEF,PAS_3
k59_305762_1	1249627.D779_0902	8.91e-40	142.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1WXUC@135613|Chromatiales	135613|Chromatiales	S	ABC-type transport system involved in multi-copper enzyme maturation, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_76603_1	1125718.HMPREF1318_2640	7.99e-83	255.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,4D3IY@85005|Actinomycetales	201174|Actinobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1483640_1	537013.CLOSTMETH_03881	2.02e-25	107.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,24BAN@186801|Clostridia,3WG8E@541000|Ruminococcaceae	186801|Clostridia	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
k59_76604_1	933262.AXAM01000042_gene1836	1.31e-68	213.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,42SVD@68525|delta/epsilon subdivisions,2WPFX@28221|Deltaproteobacteria,2MJWM@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
k59_540808_1	382464.ABSI01000011_gene2994	1.49e-16	75.1	2DQ7E@1|root,3353C@2|Bacteria,46SU5@74201|Verrucomicrobia,2IUQR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Domain of unknown function (DUF5069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5069
k59_540808_2	111780.Sta7437_0377	1.83e-17	80.1	COG1741@1|root,COG1741@2|Bacteria,1G0UH@1117|Cyanobacteria,3VJ25@52604|Pleurocapsales	1117|Cyanobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
k59_1073476_1	396588.Tgr7_3090	6.71e-86	271.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RR5Z@1236|Gammaproteobacteria,1WXE4@135613|Chromatiales	135613|Chromatiales	J	Allophanate hydrolase	-	-	3.5.1.54	ko:K01457	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120	-	R00005	RC02756	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_1073479_1	765913.ThidrDRAFT_0090	2.62e-69	216.0	COG1043@1|root,COG1043@2|Bacteria,1QKYH@1224|Proteobacteria,1S0N9@1236|Gammaproteobacteria,1WXE9@135613|Chromatiales	135613|Chromatiales	I	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
k59_423209_1	999547.KI421503_gene73	4.63e-62	200.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,281ZM@191028|Leisingera	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
k59_1483650_1	471853.Bcav_3149	1.52e-68	224.0	COG2211@1|root,COG2211@2|Bacteria,2HD4Y@201174|Actinobacteria	201174|Actinobacteria	G	Major Facilitator	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
k59_1422002_1	1209072.ALBT01000025_gene3750	7.86e-110	327.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,1FFZ3@10|Cellvibrio	1236|Gammaproteobacteria	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	GO:0003674,GO:0003824,GO:0004076,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	iZ_1308.Z0994	BATS,Radical_SAM
k59_254637_1	1353537.TP2_09910	9.86e-19	84.3	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2TR8F@28211|Alphaproteobacteria,2XMQJ@285107|Thioclava	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	soxH	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1657442_1	2074.JNYD01000014_gene7142	4.02e-151	435.0	COG0306@1|root,COG0306@2|Bacteria,2GJHK@201174|Actinobacteria,4E1VE@85010|Pseudonocardiales	201174|Actinobacteria	P	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_1657442_2	883069.HMPREF9238_00905	7.62e-23	95.1	2EGCD@1|root,33A46@2|Bacteria,2I6U8@201174|Actinobacteria,4D88J@85005|Actinomycetales	201174|Actinobacteria	S	Septum formation	-	-	-	-	-	-	-	-	-	-	-	-	Septum_form
k59_1009015_1	1173026.Glo7428_1743	5.86e-16	78.6	COG0743@1|root,COG0743@2|Bacteria,1G2CU@1117|Cyanobacteria	1117|Cyanobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_1009015_2	1121405.dsmv_2170	4.58e-43	150.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,42NJ0@68525|delta/epsilon subdivisions,2WJ7A@28221|Deltaproteobacteria,2MIEV@213118|Desulfobacterales	28221|Deltaproteobacteria	M	SMART PDZ DHR GLGF domain protein	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_1249507_1	446466.Cfla_2420	8.08e-09	63.2	COG3206@1|root,COG3206@2|Bacteria,2GPMH@201174|Actinobacteria,4F2H2@85016|Cellulomonadaceae	201174|Actinobacteria	M	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
k59_1363049_2	446469.Sked_08040	1.44e-18	87.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria	201174|Actinobacteria	P	Heavy metal translocating P-type atpase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K12954,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3,3.A.3.5	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
k59_1539047_1	247633.GP2143_06464	6.22e-24	100.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,1RP6E@1236|Gammaproteobacteria,1J4XC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	COG0084 Mg-dependent DNase	ycfH	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
k59_1187679_1	497964.CfE428DRAFT_3440	2.87e-46	162.0	COG3869@1|root,COG3869@2|Bacteria,46S55@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Protein-arginine kinase	mcsB	-	2.7.14.1	ko:K19405	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	ATP-gua_Ptrans
k59_130951_1	1255043.TVNIR_2154	8.84e-119	346.0	COG0702@1|root,COG0702@2|Bacteria,1N12V@1224|Proteobacteria,1S93R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
k59_1484530_1	935567.JAES01000002_gene773	2.27e-117	360.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1X37M@135614|Xanthomonadales	135614|Xanthomonadales	C	aconitate hydratase	acnA	-	4.2.1.117	ko:K20455	ko00640,map00640	-	R11263	RC01152	ko00000,ko00001,ko01000	-	-	-	Aconitase,Aconitase_C
k59_1714940_1	56780.SYN_00140	9.35e-78	249.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MRC1@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_541416_1	472759.Nhal_1173	7.46e-20	87.8	COG2062@1|root,COG2062@2|Bacteria,1RGWQ@1224|Proteobacteria,1S9W7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine phosphatase superfamily (branch 1)	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
k59_130963_1	1026882.MAMP_01049	1.54e-81	251.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,4609T@72273|Thiotrichales	72273|Thiotrichales	OU	signal peptide peptidase SppA, 36K type	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_958289_1	402881.Plav_1614	2.05e-63	211.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2TRPX@28211|Alphaproteobacteria,1JN0M@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_717841_1	272134.KB731324_gene3495	1.25e-58	191.0	COG3177@1|root,COG3177@2|Bacteria,1G3Q5@1117|Cyanobacteria,1H88N@1150|Oscillatoriales	1117|Cyanobacteria	K	filamentation induced by cAMP protein Fic	-	-	-	-	-	-	-	-	-	-	-	-	DUF4172,Fic,Fic_N
k59_1187695_2	331869.BAL199_10882	8.94e-74	234.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,2TQQB@28211|Alphaproteobacteria,4BPD7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Elongator protein 3, MiaB family, Radical SAM	MA20_42330	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_77460_1	762963.HMPREF9056_00409	1.36e-78	275.0	COG5263@1|root,COG5479@1|root,COG5263@2|Bacteria,COG5479@2|Bacteria,2GNDB@201174|Actinobacteria,4D3RQ@85005|Actinomycetales	201174|Actinobacteria	M	N-acetylmuramoyl-L-alanine amidase	csp	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,LGFP
k59_1422666_2	497964.CfE428DRAFT_3411	4.13e-21	87.0	COG0721@1|root,COG0721@2|Bacteria,46TA2@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
k59_1422666_3	298655.KI912267_gene6763	2.52e-63	210.0	COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,4ES8T@85013|Frankiales	201174|Actinobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	GO:0008150,GO:0040007	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_1249538_1	686340.Metal_1349	2.22e-113	338.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,1XG8N@135618|Methylococcales	135618|Methylococcales	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_306370_1	933262.AXAM01000020_gene26	1.37e-74	244.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2WJTT@28221|Deltaproteobacteria,2MITA@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
k59_1074708_1	1301098.PKB_4797	2.23e-26	106.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0042380,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046490,GO:0048037,GO:0051536,GO:0051538,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI1_1343.ECIAI1_0030,iECW_1372.ECW_m0028,iEKO11_1354.EKO11_3884,iEcHS_1320.EcHS_A0031,iEcolC_1368.EcolC_3626,iPC815.YPO0477,iSFV_1184.SFV_0023,iSF_1195.SF0026,iSFxv_1172.SFxv_0027,iS_1188.S0028,iWFL_1372.ECW_m0028,iYL1228.KPN_00024	LYTB
k59_1074708_2	1027273.GZ77_08750	6.62e-18	82.0	COG4968@1|root,COG4968@2|Bacteria,1N6QE@1224|Proteobacteria,1SCBS@1236|Gammaproteobacteria,1XMB2@135619|Oceanospirillales	135619|Oceanospirillales	NU	Type IV minor pilin ComP, DNA uptake sequence receptor	-	-	-	-	-	-	-	-	-	-	-	-	ComP_DUS,N_methyl
k59_1773419_1	631362.Thi970DRAFT_03306	1.02e-208	601.0	COG0438@1|root,COG0438@2|Bacteria,1QZ01@1224|Proteobacteria,1RZJA@1236|Gammaproteobacteria,1X05E@135613|Chromatiales	135613|Chromatiales	M	sucrose synthase	-	-	2.4.1.13	ko:K00695	ko00500,ko01100,map00500,map01100	-	R00806	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glycos_transf_1,Sucrose_synth
k59_482651_1	1009370.ALO_21876	4.05e-27	102.0	COG3293@1|root,COG3293@2|Bacteria,1UQVM@1239|Firmicutes,4H8RS@909932|Negativicutes	909932|Negativicutes	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_482651_2	484022.Fphi_0257	2.71e-12	67.0	COG3293@1|root,COG3293@2|Bacteria,1P5HD@1224|Proteobacteria,1RSHY@1236|Gammaproteobacteria,462TQ@72273|Thiotrichales	72273|Thiotrichales	L	ISFtu2. Transposase, member of the IS5 family. Identical to Q8GM03	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_1249548_1	858215.Thexy_0263	2.27e-97	300.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,42FHK@68295|Thermoanaerobacterales	186801|Clostridia	F	PFAM formate-tetrahydrofolate ligase FTHFS	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_1657479_1	497964.CfE428DRAFT_3537	4.92e-35	133.0	COG0621@1|root,COG0621@2|Bacteria,46S6B@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_1539084_1	999611.KI421504_gene494	2.3e-119	353.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,282GA@191028|Leisingera	28211|Alphaproteobacteria	L	Integrase core domain	istA	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1249551_1	935863.AWZR01000003_gene2660	1.27e-93	278.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,1RPU6@1236|Gammaproteobacteria,1X3EF@135614|Xanthomonadales	135614|Xanthomonadales	C	COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit	-	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
k59_1714962_1	471853.Bcav_4217	7.72e-67	219.0	COG1475@1|root,COG5373@1|root,COG1475@2|Bacteria,COG5373@2|Bacteria,2GNRN@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the ParB family	parB	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_541436_1	545276.KB898731_gene2229	1.41e-95	292.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1WXP9@135613|Chromatiales	135613|Chromatiales	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_1363087_1	1198232.CYCME_0292	5.72e-212	602.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,460VE@72273|Thiotrichales	72273|Thiotrichales	S	Sodium:solute symporter family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_717860_2	1226994.AMZB01000134_gene4670	3.62e-26	110.0	COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,1RPD2@1236|Gammaproteobacteria,1YFCT@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_16,TPR_19,TPR_20,TPR_8
k59_371056_1	765912.Thimo_3124	2.71e-67	208.0	COG2030@1|root,COG2030@2|Bacteria,1NKYS@1224|Proteobacteria,1SI2B@1236|Gammaproteobacteria,1WZQH@135613|Chromatiales	135613|Chromatiales	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
k59_958328_2	273677.BW34_01670	2.78e-07	51.6	COG1814@1|root,COG1814@2|Bacteria,2GIZ3@201174|Actinobacteria,4FNA8@85023|Microbacteriaceae	201174|Actinobacteria	S	VIT family	pcl	-	-	-	-	-	-	-	-	-	-	-	VIT1
k59_1074741_1	1255043.TVNIR_1411	1.44e-67	214.0	COG2738@1|root,COG2738@2|Bacteria,1RDJH@1224|Proteobacteria,1S4QY@1236|Gammaproteobacteria,1X0PS@135613|Chromatiales	135613|Chromatiales	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K06973	-	-	-	-	ko00000	-	-	-	Zn_peptidase_2
k59_1422686_1	925775.XVE_3411	9.58e-33	126.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1X31B@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1422686_2	261292.Nit79A3_2781	2.63e-19	86.3	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,2VHZZ@28216|Betaproteobacteria,3729W@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
k59_1773435_1	926550.CLDAP_24510	1.89e-36	142.0	COG2273@1|root,COG2273@2|Bacteria,2G7RY@200795|Chloroflexi	200795|Chloroflexi	G	Glycoside hydrolase family 16	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16
k59_381739_1	1210908.HSB1_43480	3.49e-53	181.0	COG0334@1|root,arCOG01352@2157|Archaea,2XU0F@28890|Euryarchaeota,23S08@183963|Halobacteria	183963|Halobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_969021_1	1500259.JQLD01000017_gene4691	1.13e-31	127.0	28M5B@1|root,2ZAJ4@2|Bacteria,1R7Y9@1224|Proteobacteria,2U94U@28211|Alphaproteobacteria,4BCYK@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_138465_1	1244869.H261_06219	4.98e-76	239.0	COG3770@1|root,COG3770@2|Bacteria,1MU9I@1224|Proteobacteria,2TR3K@28211|Alphaproteobacteria,2JSKX@204441|Rhodospirillales	204441|Rhodospirillales	M	Penicillin-insensitive murein endopeptidase	mepA	-	-	ko:K07261	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M74
k59_1259253_1	1286106.MPL1_05544	4.33e-113	341.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,45ZQZ@72273|Thiotrichales	72273|Thiotrichales	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI
k59_88210_1	382464.ABSI01000005_gene1266	6.2e-46	165.0	COG2070@1|root,COG2070@2|Bacteria,46UTY@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Nitronate monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
k59_780544_1	1121403.AUCV01000004_gene1944	4.45e-27	108.0	COG1934@1|root,COG1934@2|Bacteria,1RM28@1224|Proteobacteria,42V9N@68525|delta/epsilon subdivisions,2WRB1@28221|Deltaproteobacteria,2MM6S@213118|Desulfobacterales	28221|Deltaproteobacteria	S	OstA-like protein	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
k59_780544_2	929713.NIASO_14925	6.12e-35	127.0	COG1137@1|root,COG1137@2|Bacteria,4NDUG@976|Bacteroidetes,1IQQ1@117747|Sphingobacteriia	976|Bacteroidetes	S	ABC transporter	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
k59_725175_1	338969.Rfer_3754	8.68e-148	431.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2VJZN@28216|Betaproteobacteria,4A9YY@80864|Comamonadaceae	28216|Betaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
k59_607414_1	443218.AS9A_2461	3.13e-69	224.0	COG0069@1|root,COG2146@1|root,COG0069@2|Bacteria,COG2146@2|Bacteria,2GME2@201174|Actinobacteria,234V0@1762|Mycobacteriaceae	201174|Actinobacteria	EP	Conserved region in glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_9,Glu_syn_central,Glu_synthase,Rieske
k59_1085026_1	498211.CJA_3267	0.000532	42.7	COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,1S8UU@1236|Gammaproteobacteria,1FH8I@10|Cellvibrio	1236|Gammaproteobacteria	O	Thioredoxin-like	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
k59_1133739_1	246200.SPO3027	2.04e-36	134.0	COG0079@1|root,COG0079@2|Bacteria,1MWPU@1224|Proteobacteria,2TRV5@28211|Alphaproteobacteria,4NBK0@97050|Ruegeria	28211|Alphaproteobacteria	E	Aminotransferase class I and II	hisC1	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_910036_1	933262.AXAM01000009_gene1476	2.78e-91	291.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2MIKT@213118|Desulfobacterales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_88220_1	1047013.AQSP01000124_gene2653	4.14e-86	279.0	COG0249@1|root,COG0249@2|Bacteria,2NNN6@2323|unclassified Bacteria	2|Bacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_1370643_1	1121878.AUGL01000024_gene3722	2.66e-35	131.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_666727_1	1894.JOER01000018_gene4965	6.56e-21	85.9	COG0295@1|root,COG0295@2|Bacteria,2IHP7@201174|Actinobacteria	201174|Actinobacteria	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	GO:0003674,GO:0003824,GO:0004126,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006213,GO:0006216,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008655,GO:0009056,GO:0009058,GO:0009112,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009972,GO:0009987,GO:0016020,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019856,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042455,GO:0043094,GO:0043100,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046087,GO:0046108,GO:0046109,GO:0046112,GO:0046131,GO:0046132,GO:0046133,GO:0046134,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0047844,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0072529,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1,dCMP_cyt_deam_2
k59_666727_2	590998.Celf_2866	1.49e-101	306.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria,4F0RB@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM peptidase M20	amiA	-	-	ko:K01436,ko:K06048	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_266896_1	1313304.CALK_1522	3.24e-121	374.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria	2|Bacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1430443_1	446469.Sked_28340	1.03e-34	137.0	COG1983@1|root,COG1983@2|Bacteria,2GIVS@201174|Actinobacteria	201174|Actinobacteria	KT	PspC domain protein	pspC	-	-	-	-	-	-	-	-	-	-	-	DUF2154,PspC
k59_1430443_2	471856.Jden_0655	1.76e-20	92.4	COG1983@1|root,COG4585@1|root,COG1983@2|Bacteria,COG4585@2|Bacteria,2GJ4J@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	tcsS3	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,PspC
k59_1370651_1	765911.Thivi_3470	7.75e-94	287.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1WWT4@135613|Chromatiales	135613|Chromatiales	U	Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_431365_1	1219035.NT2_27_00020	6.89e-10	66.2	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,2K503@204457|Sphingomonadales	204457|Sphingomonadales	L	PFAM Transposase IS116 IS110 IS902 family, Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1665334_1	381666.H16_A0309	1.1e-16	81.3	COG1280@1|root,COG1280@2|Bacteria,1MXAI@1224|Proteobacteria,2VN4R@28216|Betaproteobacteria,1KGSB@119060|Burkholderiaceae	28216|Betaproteobacteria	E	LysE type translocator	-	-	-	ko:K05834	-	-	-	-	ko00000,ko02000	2.A.76.1.1	-	-	LysE
k59_1546556_1	1336243.JAEA01000013_gene3247	1.48e-92	298.0	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2TRUN@28211|Alphaproteobacteria,1JT39@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Aminotran_3,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,Methyltransf_12,PP-binding,Thioesterase,ketoacyl-synt
k59_138486_1	1205680.CAKO01000030_gene4935	1e-119	376.0	COG1132@1|root,COG4988@1|root,COG1132@2|Bacteria,COG4988@2|Bacteria,1MUBM@1224|Proteobacteria,2U0IT@28211|Alphaproteobacteria,2JQVP@204441|Rhodospirillales	204441|Rhodospirillales	V	ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
k59_910076_1	1454010.JEOE01000001_gene675	2.07e-68	227.0	COG0815@1|root,COG0815@2|Bacteria,2GJ9F@201174|Actinobacteria,4F0G7@85016|Cellulomonadaceae	201174|Actinobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_548761_1	880072.Desac_0259	6.29e-66	216.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria,2MQUI@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
k59_1195423_2	639030.JHVA01000001_gene3479	2.17e-08	59.7	COG0457@1|root,COG0457@2|Bacteria,3Y3VT@57723|Acidobacteria,2JHXZ@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_910077_1	1249627.D779_0142	1.21e-47	165.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,1RMAE@1236|Gammaproteobacteria,1WWTZ@135613|Chromatiales	135613|Chromatiales	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
k59_1781146_2	391615.ABSJ01000026_gene144	1.71e-87	261.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,1J5ZJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_1781146_3	395019.Bmul_1261	4.96e-41	143.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2VH2E@28216|Betaproteobacteria,1K0E6@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_431375_1	367299.JOEE01000005_gene3511	1.46e-118	349.0	COG0133@1|root,COG0133@2|Bacteria,2GM7Z@201174|Actinobacteria,4FF8X@85021|Intrasporangiaceae	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PALP
k59_266936_1	1454010.JEOE01000058_gene1075	5.19e-86	266.0	COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,4F0ZK@85016|Cellulomonadaceae	201174|Actinobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_725208_1	76114.ebA2533	2.04e-126	382.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,2KUY0@206389|Rhodocyclales	206389|Rhodocyclales	S	COG0488 ATPase components of ABC transporters with duplicated ATPase domains	yheS	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_1195426_1	999547.KI421500_gene2162	2.68e-42	150.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,2TR7U@28211|Alphaproteobacteria,27ZED@191028|Leisingera	28211|Alphaproteobacteria	M	Mechanosensitive ion channel	mscS	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel,TM_helix
k59_88262_2	595593.JREV01000019_gene3158	1.23e-22	95.1	COG2334@1|root,COG2334@2|Bacteria,2I8IC@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_969092_1	243159.AFE_2861	1e-78	246.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,1RP16@1236|Gammaproteobacteria,2NCFN@225057|Acidithiobacillales	225057|Acidithiobacillales	M	Secretion protein, HlyD	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
k59_381813_1	1163617.SCD_n01804	1.07e-105	315.0	28IVT@1|root,2Z8U5@2|Bacteria,1R7G9@1224|Proteobacteria,2W17G@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_780574_2	1184609.KILIM_076_00070	3.52e-16	77.0	COG0008@1|root,COG0008@2|Bacteria,2H1TZ@201174|Actinobacteria,4F6GF@85018|Dermatophilaceae	201174|Actinobacteria	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
k59_1370671_2	713587.THITH_01370	3.1e-12	65.9	COG3302@1|root,COG3302@2|Bacteria,1MWY1@1224|Proteobacteria,1S09K@1236|Gammaproteobacteria,1WX6Q@135613|Chromatiales	135613|Chromatiales	S	PFAM DMSO reductase anchor subunit (DmsC)	-	-	-	ko:K21309	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001	-	-	-	DmsC
k59_33302_1	765911.Thivi_1305	7.51e-23	95.1	COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,1S05R@1236|Gammaproteobacteria,1WXBW@135613|Chromatiales	135613|Chromatiales	C	nitrate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_33302_2	2340.JV46_26680	2.68e-25	103.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,1RNTJ@1236|Gammaproteobacteria,1JB7M@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
k59_381818_1	396014.BF93_08480	4.82e-10	65.5	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2GXGF@201174|Actinobacteria,4FCDY@85020|Dermabacteraceae	201174|Actinobacteria	M	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
k59_1493764_1	13035.Dacsa_2625	4.69e-21	100.0	COG3210@1|root,COG3595@1|root,COG4070@1|root,COG3210@2|Bacteria,COG3595@2|Bacteria,COG4070@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	ko:K15125,ko:K20276	ko02024,ko05133,map02024,map05133	-	-	-	ko00000,ko00001,ko00536	-	-	-	CHU_C,DUF4097,FG-GAP_2,Glug,Haemagg_act,Laminin_G_3,PA14,SprB
k59_1085084_1	743299.Acife_1818	8.28e-39	143.0	COG1453@1|root,COG1453@2|Bacteria,1NIR6@1224|Proteobacteria,1T3EJ@1236|Gammaproteobacteria,2NC25@225057|Acidithiobacillales	225057|Acidithiobacillales	S	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
k59_969108_1	335543.Sfum_0773	1.17e-10	60.5	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,42V5C@68525|delta/epsilon subdivisions,2WRC4@28221|Deltaproteobacteria,2MQND@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	PTS HPr component phosphorylation site	ptsH	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
k59_969108_2	177437.HRM2_19030	4.59e-45	162.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,42P77@68525|delta/epsilon subdivisions,2WK7E@28221|Deltaproteobacteria,2MIQB@213118|Desulfobacterales	28221|Deltaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_33311_1	1249627.D779_0403	3.02e-126	364.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1WWZU@135613|Chromatiales	135613|Chromatiales	M	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
k59_1546580_1	1283284.AZUK01000001_gene1734	8.92e-27	115.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1Y51C@135624|Aeromonadales	135624|Aeromonadales	NU	Neisseria PilC beta-propeller domain	-	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
k59_1259329_1	2340.JV46_13030	1.17e-97	291.0	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,1S7ID@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_969117_1	1521187.JPIM01000024_gene697	1.79e-78	251.0	COG0318@1|root,COG0318@2|Bacteria,2G5Q8@200795|Chloroflexi,376GY@32061|Chloroflexia	32061|Chloroflexia	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_88297_1	367299.JOEE01000007_gene103	6.6e-101	307.0	COG1012@1|root,COG1012@2|Bacteria,2GJ95@201174|Actinobacteria,4FFEM@85021|Intrasporangiaceae	201174|Actinobacteria	C	part of alternative pathway from alpha-ketoglutarate to succinate	gabD2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009013,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1133799_1	95619.PM1_0219330	8.19e-41	152.0	COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	ykoW	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9
k59_780594_1	1380347.JNII01000007_gene308	9.22e-85	269.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria,4ERPW@85013|Frankiales	201174|Actinobacteria	KOT	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
k59_1259345_1	1095769.CAHF01000010_gene1267	3.6e-13	66.2	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,2VRMG@28216|Betaproteobacteria,4741N@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Molybdopterin converting factor, large subunit	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
k59_1259345_2	742823.HMPREF9465_00316	5.06e-26	98.6	COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,2VVSP@28216|Betaproteobacteria,4PRBP@995019|Sutterellaceae	28216|Betaproteobacteria	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
k59_1259345_3	232721.Ajs_3203	5.53e-12	65.1	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VIFK@28216|Betaproteobacteria,4AB3M@80864|Comamonadaceae	28216|Betaproteobacteria	H	MoeA domain protein domain I and II	moeA1	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_267001_1	1713.JOFV01000003_gene1438	2.47e-57	193.0	COG0454@1|root,COG0456@2|Bacteria,2I8J8@201174|Actinobacteria,4F1YB@85016|Cellulomonadaceae	201174|Actinobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1430508_1	367299.JOEE01000005_gene3468	2.51e-174	489.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4FEMK@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_197124_2	472759.Nhal_3801	8.56e-67	211.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1WWCV@135613|Chromatiales	135613|Chromatiales	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_431416_1	1116472.MGMO_8c00480	3e-49	177.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1XEG1@135618|Methylococcales	135618|Methylococcales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_1546598_1	1120947.ATUX01000007_gene800	1.87e-10	60.1	COG2755@1|root,COG2755@2|Bacteria,2IA8J@201174|Actinobacteria,4D55Z@85005|Actinomycetales	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
k59_1546598_2	266940.Krad_1228	1.54e-78	263.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase E1 component	kgd	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1248c	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_33366_1	105559.Nwat_1439	3.3e-19	87.0	COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,1RQWX@1236|Gammaproteobacteria,1WZGU@135613|Chromatiales	135613|Chromatiales	C	PFAM Glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_33366_2	90675.XP_010424272.1	1.48e-17	88.6	COG0363@1|root,KOG3147@2759|Eukaryota,37JE7@33090|Viridiplantae,3GFR3@35493|Streptophyta,3HR5D@3699|Brassicales	35493|Streptophyta	G	6-phosphogluconolactonase	-	GO:0002229,GO:0002239,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006081,GO:0006082,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009605,GO:0009607,GO:0009617,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0042126,GO:0042128,GO:0042579,GO:0042742,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046496,GO:0050896,GO:0051156,GO:0051186,GO:0051704,GO:0051707,GO:0051775,GO:0052689,GO:0055086,GO:0071461,GO:0071704,GO:0071941,GO:0072524,GO:0098542,GO:1901135,GO:1901360,GO:1901564,GO:2001057	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
k59_33366_3	1026882.MAMP_03168	1.68e-77	238.0	COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,1S0GN@1236|Gammaproteobacteria,4612H@72273|Thiotrichales	72273|Thiotrichales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1134392_1	1267534.KB906755_gene3906	7.41e-42	155.0	COG3064@1|root,COG3064@2|Bacteria,3Y6QP@57723|Acidobacteria	57723|Acidobacteria	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
k59_1431157_1	1307761.L21SP2_2602	4.66e-61	207.0	COG3808@1|root,COG3808@2|Bacteria,2J6RD@203691|Spirochaetes	203691|Spirochaetes	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1547175_1	1384054.N790_07215	4.19e-62	211.0	COG0457@1|root,COG0457@2|Bacteria,1Q3YA@1224|Proteobacteria,1RN2D@1236|Gammaproteobacteria,1X4T5@135614|Xanthomonadales	135614|Xanthomonadales	S	Peptidase family M49	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M49
k59_1371270_1	589873.EP13_07255	1.53e-36	125.0	COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,1S8UC@1236|Gammaproteobacteria,467T6@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	yciI	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K05527,ko:K09780	-	-	-	-	ko00000,ko03000	-	-	-	YCII
k59_1371270_2	1123256.KB907926_gene751	4.17e-26	99.4	COG0271@1|root,COG0271@2|Bacteria,1QCDM@1224|Proteobacteria,1RTFD@1236|Gammaproteobacteria,1X7ES@135614|Xanthomonadales	135614|Xanthomonadales	T	Belongs to the BolA IbaG family	-	-	-	ko:K05527	-	-	-	-	ko00000,ko03000	-	-	-	BolA
k59_139118_1	10116.ENSRNOP00000054244	2.77e-11	70.1	COG1011@1|root,COG3173@1|root,KOG1469@2759|Eukaryota,KOG3085@2759|Eukaryota,38BWX@33154|Opisthokonta,3BDYX@33208|Metazoa,3CUUN@33213|Bilateria,48ABS@7711|Chordata,4933E@7742|Vertebrata,3JAB2@40674|Mammalia,35FNE@314146|Euarchontoglires,4Q3AZ@9989|Rodentia	33208|Metazoa	I	Acyl-CoA dehydrogenase, C-terminal domain	ACAD10	GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0031974,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	-	ko:K11729	-	-	-	-	ko00000	-	-	-	APH,Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,HAD_2,Hydrolase
k59_89374_2	90813.JQMT01000001_gene813	8.92e-08	50.4	COG5007@1|root,COG5007@2|Bacteria	2|Bacteria	K	2 iron, 2 sulfur cluster binding	yrbA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051536,GO:0051537,GO:0051540	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	BolA
k59_911214_1	1123368.AUIS01000028_gene1326	2.35e-31	128.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_911214_2	1479237.JMLY01000001_gene1603	2.43e-47	158.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RR3R@1236|Gammaproteobacteria,465VZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_549430_1	640081.Dsui_1450	2.79e-86	263.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,2VM6F@28216|Betaproteobacteria,2KUQG@206389|Rhodocyclales	206389|Rhodocyclales	T	Serine/threonine phosphatases, family 2C, catalytic domain	pppL	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
k59_725834_1	65093.PCC7418_0644	5.67e-29	112.0	COG0667@1|root,COG0667@2|Bacteria,1G2Y9@1117|Cyanobacteria	1117|Cyanobacteria	C	aldo keto reductase	-	-	1.1.1.91	ko:K05882	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
k59_725834_2	1211112.ALJC01000105_gene2315	3.67e-98	295.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Belongs to the NadC ModD family	nadC	GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_0109	QRPTase_C,QRPTase_N
k59_34545_1	589865.DaAHT2_0407	7.87e-05	44.7	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKJX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_34545_2	926556.Echvi_2421	5.54e-22	97.8	COG5000@1|root,COG5000@2|Bacteria,4NEWF@976|Bacteroidetes,47JZG@768503|Cytophagia	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_970242_1	2340.JV46_21990	2.69e-76	239.0	COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,1RQAK@1236|Gammaproteobacteria,1J4HP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Phosphoenolpyruvate phosphomutase	aceA	GO:0003674,GO:0003824,GO:0004451,GO:0005488,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046487,GO:0071704	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	e_coli_core.b4015,iAF1260.b4015,iB21_1397.B21_03847,iBWG_1329.BWG_3671,iE2348C_1286.E2348C_4318,iEC042_1314.EC042_4377,iEC55989_1330.EC55989_4500,iECABU_c1320.ECABU_c45310,iECBD_1354.ECBD_4022,iECB_1328.ECB_03887,iECDH10B_1368.ECDH10B_4204,iECDH1ME8569_1439.ECDH1ME8569_3871,iECD_1391.ECD_03887,iECED1_1282.ECED1_4722,iECIAI1_1343.ECIAI1_4235,iECIAI39_1322.ECIAI39_4401,iECNA114_1301.ECNA114_4164,iECO103_1326.ECO103_4759,iECO111_1330.ECO111_4827,iECO26_1355.ECO26_5119,iECP_1309.ECP_4225,iECSE_1348.ECSE_4300,iECSF_1327.ECSF_3865,iECUMN_1333.ECUMN_4541,iECW_1372.ECW_m4374,iEKO11_1354.EKO11_4310,iETEC_1333.ETEC_4270,iEcDH1_1363.EcDH1_3982,iEcE24377_1341.EcE24377A_4557,iEcHS_1320.EcHS_A4249,iEcSMS35_1347.EcSMS35_4469,iEcolC_1368.EcolC_4015,iJN746.PP_4116,iJO1366.b4015,iJR904.b4015,iLF82_1304.LF82_0012,iNRG857_1313.NRG857_20015,iSDY_1059.SDY_4328,iUMNK88_1353.UMNK88_4859,iWFL_1372.ECW_m4374,iY75_1357.Y75_RS20880	ICL
k59_970242_2	316275.VSAL_I2557	1.1e-11	63.5	COG0684@1|root,COG0684@2|Bacteria,1RH18@1224|Proteobacteria,1RS9U@1236|Gammaproteobacteria,1XX44@135623|Vibrionales	135623|Vibrionales	H	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions	-	-	-	ko:K02553	-	-	-	-	ko00000,ko03019	-	-	-	RraA-like
k59_34546_2	96561.Dole_2551	1.38e-60	198.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,42MJT@68525|delta/epsilon subdivisions,2WJ7W@28221|Deltaproteobacteria,2MHNI@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_315009_2	1121439.dsat_0674	2.85e-08	54.7	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,42NYV@68525|delta/epsilon subdivisions,2WPI0@28221|Deltaproteobacteria,2MFWD@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_867656_1	1158165.KB898877_gene1211	2.25e-104	337.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,1RMW9@1236|Gammaproteobacteria,1WXFY@135613|Chromatiales	135613|Chromatiales	G	Glycosyltransferase 36 associated	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
k59_1802454_1	1121405.dsmv_0430	7.72e-21	90.1	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WJYV@28221|Deltaproteobacteria,2MJ0G@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_1747719_1	101510.RHA1_ro01673	2.32e-21	96.3	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4FUYC@85025|Nocardiaceae	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Helicase_C,ResIII,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1629306_1	1267005.KB911258_gene362	1.42e-72	226.0	COG5402@1|root,COG5402@2|Bacteria,1N26C@1224|Proteobacteria,2TT9K@28211|Alphaproteobacteria,3N79F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1214)	MA20_15585	-	-	-	-	-	-	-	-	-	-	-	DUF1214
k59_1522120_1	857087.Metme_0526	4.14e-39	150.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,1XEJM@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0753 family	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k59_573030_1	1198449.ACAM_0126	6.27e-16	80.9	COG0382@1|root,arCOG00476@2157|Archaea,2XQNM@28889|Crenarchaeota	28889|Crenarchaeota	H	PFAM UbiA prenyltransferase	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
k59_632100_1	1260251.SPISAL_00065	5.18e-56	187.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1WXMZ@135613|Chromatiales	135613|Chromatiales	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_1571192_1	713586.KB900536_gene2191	1.68e-86	271.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1WWEC@135613|Chromatiales	135613|Chromatiales	S	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
k59_1629334_1	1304865.JAGF01000001_gene2392	8.8e-163	470.0	COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria,4F12N@85016|Cellulomonadaceae	201174|Actinobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1802490_1	1117315.AHCA01000004_gene895	1.1e-23	103.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,2Q00P@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	COG1519 3-deoxy-D-manno-octulosonic-acid transferase	kdtA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	iECNA114_1301.ECNA114_3778,iUMNK88_1353.UMNK88_4417	Glycos_transf_1,Glycos_transf_N
k59_1220118_1	367299.JOEE01000004_gene981	3.41e-112	337.0	COG0018@1|root,COG0018@2|Bacteria,2GKQ3@201174|Actinobacteria,4FE5V@85021|Intrasporangiaceae	201174|Actinobacteria	J	Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_455791_2	713586.KB900536_gene612	1.24e-53	188.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales	135613|Chromatiales	D	DNA segregation ATPase FtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1395124_1	497965.Cyan7822_3772	3.17e-49	172.0	COG5361@1|root,COG5361@2|Bacteria,1G49Q@1117|Cyanobacteria,3KFX6@43988|Cyanothece	1117|Cyanobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_455793_2	105559.Nwat_2242	1.01e-15	73.6	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1WWUP@135613|Chromatiales	135613|Chromatiales	V	PFAM N-acetylmuramoyl-L-alanine amidase family 2	-	-	3.5.1.28	ko:K03806	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	Amidase_2
k59_632119_1	312284.A20C1_05931	5.17e-49	162.0	COG1528@1|root,COG1528@2|Bacteria,2IG5S@201174|Actinobacteria,3UXFR@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	Ferritin-like domain	bfrB	GO:0001666,GO:0003674,GO:0003824,GO:0004322,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009987,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0030312,GO:0033212,GO:0033214,GO:0036293,GO:0042592,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051235,GO:0051238,GO:0051409,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070482,GO:0071944,GO:0097577,GO:0098771	1.16.3.1	ko:K22336	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
k59_1630730_1	266835.14025498	8.32e-12	65.5	COG0010@1|root,COG3457@1|root,COG0010@2|Bacteria,COG3457@2|Bacteria,1MW9K@1224|Proteobacteria,2U36W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the arginase family	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,Arginase
k59_1630730_2	267747.PPA2280	2.73e-54	192.0	COG5012@1|root,COG5012@2|Bacteria,2I5QU@201174|Actinobacteria,4DWZR@85009|Propionibacteriales	201174|Actinobacteria	S	D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit	-	-	5.4.3.5	ko:K17898	ko00472,map00472	-	R02461	RC00719	ko00000,ko00001,ko01000	-	-	-	B12-binding,Lys-AminoMut_A,OAM_dimer
k59_1691663_1	243164.DET0166	3.85e-121	352.0	COG2801@1|root,COG2801@2|Bacteria,2G8GQ@200795|Chloroflexi,34DDP@301297|Dehalococcoidia	301297|Dehalococcoidia	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_692643_1	944479.JQLX01000016_gene317	6.26e-69	223.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42PAM@68525|delta/epsilon subdivisions,2WJZW@28221|Deltaproteobacteria,2M6SZ@213113|Desulfurellales	28221|Deltaproteobacteria	E	Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_340844_1	1266908.AQPB01000043_gene1431	3.13e-61	202.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQMI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	Type II secretory pathway component PulF	mshG	-	-	ko:K02505,ko:K12278	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
k59_801185_1	1304865.JAGF01000001_gene2477	5.44e-82	273.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,COG1145@2|Bacteria,2I995@201174|Actinobacteria	201174|Actinobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_751870_1	1123393.KB891317_gene2367	7.35e-67	226.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJI0@28216|Betaproteobacteria,1KSRU@119069|Hydrogenophilales	119069|Hydrogenophilales	P	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
k59_164878_1	864051.BurJ1DRAFT_0559	1.07e-41	138.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2VU4I@28216|Betaproteobacteria,1KMDV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA1	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
k59_164878_2	1173026.Glo7428_3186	2.89e-18	80.9	COG4891@1|root,COG4891@2|Bacteria,1G7CI@1117|Cyanobacteria	1117|Cyanobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
k59_1156583_1	1349820.M707_22620	2.38e-15	76.6	COG0730@1|root,COG0730@2|Bacteria,2I5VT@201174|Actinobacteria,1W7ZT@1268|Micrococcaceae	201174|Actinobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_1630756_1	1123229.AUBC01000014_gene2869	3.23e-84	273.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2TVZI@28211|Alphaproteobacteria,3JTEA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Formate dehydrogenase, alpha subunit	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1630760_1	485915.Dret_1795	2.65e-63	206.0	COG0475@1|root,COG0475@2|Bacteria,1RFKE@1224|Proteobacteria,43B2P@68525|delta/epsilon subdivisions,2X6GM@28221|Deltaproteobacteria,2M9P0@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1572615_1	649638.Trad_0500	9.05e-27	111.0	COG1105@1|root,COG1105@2|Bacteria,1WMFJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	PFAM pfkB family carbohydrate kinase	-	-	2.7.1.11	ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
k59_1630762_1	765911.Thivi_4487	1.3e-45	169.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1WW7V@135613|Chromatiales	135613|Chromatiales	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_1289888_1	1283300.ATXB01000001_gene2393	9.86e-116	340.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,1XE3K@135618|Methylococcales	135618|Methylococcales	M	PFAM YkuD domain	-	-	-	ko:K16291	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	YkuD
k59_164904_1	981384.AEYW01000028_gene4249	1.25e-37	137.0	COG1409@1|root,COG1409@2|Bacteria,1NI34@1224|Proteobacteria	1224|Proteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_1456795_1	247490.KSU1_C1443	9.26e-29	119.0	COG1234@1|root,COG1234@2|Bacteria,2J27A@203682|Planctomycetes	203682|Planctomycetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_869156_1	439235.Dalk_5087	5.07e-192	541.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,43B8Z@68525|delta/epsilon subdivisions,2X6NB@28221|Deltaproteobacteria,2MPI8@213118|Desulfobacterales	1224|Proteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_574132_1	450380.JPSY01000001_gene843	2.65e-87	274.0	COG2865@1|root,COG2865@2|Bacteria,2I3IG@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
k59_869161_1	367299.JOEE01000001_gene1724	2.74e-47	159.0	2DQVM@1|root,338Y0@2|Bacteria,2ISKA@201174|Actinobacteria,4FGKE@85021|Intrasporangiaceae	201174|Actinobacteria	S	LppX_LprAFG lipoprotein	-	-	-	ko:K14954	ko05152,map05152	-	-	-	ko00000,ko00001	-	-	-	LppX_LprAFG
k59_1803554_1	571166.KI421509_gene1284	1.79e-83	266.0	COG1178@1|root,COG1178@2|Bacteria,1MXZZ@1224|Proteobacteria,2TT7F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type Fe3 transport system permease component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_1221426_1	879212.DespoDRAFT_03201	5.38e-110	332.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2MHPV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1289936_1	243233.MCA0568	1.81e-66	212.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1XE51@135618|Methylococcales	135618|Methylococcales	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_1115190_1	446469.Sked_20330	1.92e-58	187.0	COG0300@1|root,COG0300@2|Bacteria,2H30G@201174|Actinobacteria	201174|Actinobacteria	S	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1630819_1	870187.Thini_3699	2.45e-18	82.4	COG2979@1|root,COG2979@2|Bacteria,1RGEB@1224|Proteobacteria,1S9HB@1236|Gammaproteobacteria,46319@72273|Thiotrichales	72273|Thiotrichales	S	Protein of unknown function (DUF533)	-	-	-	-	-	-	-	-	-	-	-	-	DUF533
k59_1691742_1	555079.Toce_0243	8.05e-54	195.0	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.17.1.10,1.17.1.9,1.97.1.9	ko:K00123,ko:K12527,ko:K15022	ko00450,ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00450,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519,R07229	RC02420,RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Pyr_redox_2,Pyr_redox_3
k59_1691742_2	1168034.FH5T_19015	9.73e-41	149.0	COG0644@1|root,COG0644@2|Bacteria,4P040@976|Bacteroidetes	976|Bacteroidetes	C	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1115207_1	367299.JOEE01000001_gene1632	4.09e-87	265.0	COG0604@1|root,COG0604@2|Bacteria,2GK7Y@201174|Actinobacteria,4FF13@85021|Intrasporangiaceae	201174|Actinobacteria	C	NADPH quinone	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1115207_2	1206101.AZXC01000019_gene1530	1.28e-25	100.0	COG0454@1|root,COG0456@2|Bacteria,2INVM@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	2.3.1.57	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
k59_1524021_1	930171.Asphe3_17860	2e-37	131.0	2E4PM@1|root,32ZI9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1630830_1	1123229.AUBC01000024_gene4584	3.67e-27	115.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2TRSN@28211|Alphaproteobacteria,3JV15@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	AsmA-like C-terminal region	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
k59_869200_1	1894.JOER01000088_gene3402	1.3e-08	57.8	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_869200_2	436229.JOEH01000004_gene326	2.91e-144	425.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,2NEN1@228398|Streptacidiphilus	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_633255_2	312153.Pnuc_1064	4.53e-19	85.9	COG1595@1|root,COG1595@2|Bacteria,1R9WC@1224|Proteobacteria,2VQ28@28216|Betaproteobacteria,1K3KU@119060|Burkholderiaceae	28216|Betaproteobacteria	K	RNA polymerase	sigE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_751963_1	4081.Solyc07g041510.1.1	0.000357	49.3	COG0457@1|root,KOG2002@2759|Eukaryota,37N0J@33090|Viridiplantae,3G9UW@35493|Streptophyta,44BUK@71274|asterids	35493|Streptophyta	P	Tetratricopeptide repeat	-	GO:0000122,GO:0000428,GO:0000785,GO:0000993,GO:0001098,GO:0001099,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006325,GO:0006355,GO:0006357,GO:0006464,GO:0006479,GO:0006807,GO:0006996,GO:0008023,GO:0008150,GO:0008152,GO:0008213,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009909,GO:0009910,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010638,GO:0016020,GO:0016043,GO:0016569,GO:0016570,GO:0016571,GO:0016591,GO:0016593,GO:0018022,GO:0018023,GO:0018193,GO:0018205,GO:0019219,GO:0019222,GO:0019538,GO:0019899,GO:0030880,GO:0031056,GO:0031058,GO:0031060,GO:0031062,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031399,GO:0031401,GO:0031974,GO:0031981,GO:0032259,GO:0032268,GO:0032270,GO:0032784,GO:0032786,GO:0032968,GO:0032991,GO:0033043,GO:0033044,GO:0034243,GO:0034968,GO:0035327,GO:0036211,GO:0043170,GO:0043175,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044451,GO:0044464,GO:0044877,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045944,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048580,GO:0048581,GO:0048831,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051254,GO:0051276,GO:0051568,GO:0051569,GO:0051571,GO:0055029,GO:0060255,GO:0061695,GO:0065007,GO:0070013,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0080182,GO:1901564,GO:1902275,GO:1902494,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1905269,GO:1990234,GO:2000026,GO:2000112,GO:2000113,GO:2000241,GO:2000242,GO:2001141,GO:2001252	-	ko:K15176	-	-	-	-	ko00000,ko03021	-	-	-	TPR_1,TPR_16,TPR_2,TPR_6,TPR_8
k59_1691749_2	765912.Thimo_3344	9.64e-18	80.1	2DNYF@1|root,32ZSU@2|Bacteria,1N8ZB@1224|Proteobacteria,1S5ZH@1236|Gammaproteobacteria,1WYS0@135613|Chromatiales	135613|Chromatiales	S	PFAM HupH hydrogenase expression protein, C-terminal conserved region	-	-	-	ko:K03618	-	-	-	-	ko00000	-	-	-	HupH_C
k59_1289969_1	740709.A10D4_11581	4.09e-28	106.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,1S24R@1236|Gammaproteobacteria,2QF1C@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Belongs to the UPF0312 family	yceI	-	-	-	-	-	-	-	-	-	-	-	YceI
k59_1115227_1	1380380.JIAX01000010_gene281	1.9e-08	62.4	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2TVQS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type Fe3 transport system permease component	afuB2	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_801246_1	305700.B447_11947	1.42e-74	238.0	COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2VMKW@28216|Betaproteobacteria,2KYIB@206389|Rhodocyclales	206389|Rhodocyclales	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
k59_1041681_2	1279019.ARQK01000060_gene2192	9.44e-52	172.0	COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,1S3VU@1236|Gammaproteobacteria,1WXXM@135613|Chromatiales	135613|Chromatiales	S	HAD-superfamily hydrolase, subfamily IA, variant 1	-	-	3.1.3.105	ko:K22292	ko00520,map00520	-	R11785	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_1524041_1	1177594.MIC448_1210009	7.37e-11	70.1	COG2189@1|root,COG2189@2|Bacteria,2I7C7@201174|Actinobacteria	201174|Actinobacteria	L	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
k59_340926_1	1385518.N798_06935	1.19e-91	270.0	COG2343@1|root,COG2343@2|Bacteria,2IKUM@201174|Actinobacteria,4FGD7@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
k59_1289983_1	1125863.JAFN01000001_gene1445	2.89e-54	176.0	COG4393@1|root,COG4393@2|Bacteria,1R507@1224|Proteobacteria,42NQA@68525|delta/epsilon subdivisions,2WQ0C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2318
k59_801251_1	574966.KB898652_gene1642	2.12e-49	172.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1XIU0@135619|Oceanospirillales	135619|Oceanospirillales	C	FAD linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1289984_1	637389.Acaty_c0108	8.81e-19	86.3	COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1MVH7@1224|Proteobacteria,1S09Z@1236|Gammaproteobacteria,2NDFK@225057|Acidithiobacillales	225057|Acidithiobacillales	KL	ParB-like nuclease domain	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase,ParBc
k59_1396505_1	396588.Tgr7_0751	2.38e-34	125.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1WWVP@135613|Chromatiales	135613|Chromatiales	C	PFAM Cytochrome C1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
k59_1396505_2	316275.VSAL_I2659	1.35e-10	60.5	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria,1XTQ9@135623|Vibrionales	135623|Vibrionales	O	stringent starvation protein A	sspA	-	-	ko:K03599	-	-	-	-	ko00000,ko02000,ko03021	1.A.12.3.1	-	-	GST_C,GST_N,GST_N_3
k59_515351_1	1122622.ATWJ01000009_gene3145	1.19e-37	141.0	COG1432@1|root,COG1432@2|Bacteria,2HB6H@201174|Actinobacteria,4FFNZ@85021|Intrasporangiaceae	201174|Actinobacteria	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
k59_1524052_1	1232437.KL662031_gene2518	2.15e-86	263.0	COG1152@1|root,COG1152@2|Bacteria,1R2X2@1224|Proteobacteria,43DHE@68525|delta/epsilon subdivisions,2X8P7@28221|Deltaproteobacteria,2MK7W@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1456874_1	765912.Thimo_1750	1.98e-27	101.0	2ESGD@1|root,335Y7@2|Bacteria,1NC37@1224|Proteobacteria,1SFHH@1236|Gammaproteobacteria,1WZK6@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1456874_2	1128421.JAGA01000003_gene3138	1.83e-35	129.0	COG1136@1|root,COG1136@2|Bacteria	2|Bacteria	V	lipoprotein transporter activity	-	GO:0008150,GO:0009405,GO:0009605,GO:0009607,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1524057_1	1394178.AWOO02000064_gene77	4.55e-98	291.0	28P5T@1|root,2ZC0N@2|Bacteria,2GP34@201174|Actinobacteria,4EGR1@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_584399_1	1454004.AW11_02488	1.31e-117	347.0	COG0394@1|root,COG0704@1|root,COG0394@2|Bacteria,COG0704@2|Bacteria	2|Bacteria	P	negative regulation of phosphate transmembrane transport	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	1.20.4.1,3.1.3.48	ko:K01104,ko:K02039,ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	PhoU
k59_1759665_1	96561.Dole_2037	6.97e-84	265.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,2MHZK@213118|Desulfobacterales	28221|Deltaproteobacteria	EH	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_704311_1	414684.RC1_0381	1.2e-60	206.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2JPR7@204441|Rhodospirillales	204441|Rhodospirillales	I	COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit	-	-	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_1169917_2	1383055.S5YQY8_9CAUD	7.1e-14	77.8	4QH13@10239|Viruses,4QWVB@35237|dsDNA viruses  no RNA stage,4QT10@28883|Caudovirales,4QNAI@10699|Siphoviridae	10699|Siphoviridae	S	nuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_811315_1	1123257.AUFV01000003_gene1059	8.39e-60	191.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria,1X6GJ@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
k59_811315_2	76869.PputGB1_5128	6.12e-19	86.3	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1YWNV@136845|Pseudomonas putida group	1236|Gammaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	GO:0000166,GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b3389,iBWG_1329.BWG_3080,iECDH10B_1368.ECDH10B_3564,iECDH1ME8569_1439.ECDH1ME8569_3268,iECNA114_1301.ECNA114_3486,iEcDH1_1363.EcDH1_0324,iJO1366.b3389,iJR904.b3389,iY75_1357.Y75_RS20275	DHQ_synthase
k59_1169938_1	1163617.SCD_n01883	4.75e-91	288.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,2WEVG@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	ko:K16886	-	-	-	-	ko00000	-	-	-	Fer4,FlpD,Pyr_redox_2
k59_1169963_2	1121405.dsmv_2076	5.61e-28	109.0	COG3568@1|root,COG3568@2|Bacteria,1RBWV@1224|Proteobacteria,42QPA@68525|delta/epsilon subdivisions,2WMPU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_644115_1	314287.GB2207_04089	7.61e-27	111.0	COG2304@1|root,COG2304@2|Bacteria,1QBPM@1224|Proteobacteria,1RQIU@1236|Gammaproteobacteria,1J4PZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Secreted protein, containing von Willebrand factor (VWF) type	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1815894_1	590998.Celf_0609	1.06e-90	278.0	COG3642@1|root,COG3642@2|Bacteria,2GIX0@201174|Actinobacteria,4F13Z@85016|Cellulomonadaceae	201174|Actinobacteria	T	Domain of unknown function (DUF4032)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4032,Kdo
k59_1169993_1	367299.JOEE01000006_gene707	5.69e-101	305.0	COG0215@1|root,COG0215@2|Bacteria,2GJF2@201174|Actinobacteria,4FECH@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
k59_704393_1	296591.Bpro_4334	1.16e-166	475.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria,4ABVU@80864|Comamonadaceae	28216|Betaproteobacteria	L	Integrase, catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_584474_1	265072.Mfla_1007	5.71e-05	46.6	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2VI4M@28216|Betaproteobacteria,2KM33@206350|Nitrosomonadales	206350|Nitrosomonadales	K	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
k59_1815919_1	441620.Mpop_2368	5.76e-52	192.0	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,1JS5X@119045|Methylobacteriaceae	28211|Alphaproteobacteria	QU	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
k59_584477_2	494419.ALPM01000031_gene3258	9.95e-35	120.0	COG2161@1|root,COG2161@2|Bacteria,2IQ6H@201174|Actinobacteria,1WBU7@1268|Micrococcaceae	201174|Actinobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	yefM	-	-	ko:K19159	-	-	-	-	ko00000,ko02048	-	-	-	PhdYeFM_antitox
k59_1759777_1	1463895.JODA01000031_gene2660	1.05e-12	68.6	COG2175@1|root,COG2175@2|Bacteria,2GNUC@201174|Actinobacteria	201174|Actinobacteria	Q	taurine catabolism dioxygenase	-	-	1.14.11.17	ko:K03119,ko:K22303	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
k59_1759777_2	388399.SSE37_19132	8.97e-59	186.0	COG2105@1|root,COG2105@2|Bacteria,1N80E@1224|Proteobacteria,2U5YU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Gamma-glutamyl cyclotransferase, AIG2-like	-	-	-	-	-	-	-	-	-	-	-	-	GGACT
k59_1815942_2	1307759.JOMJ01000003_gene1692	2.06e-45	162.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1PFBF@1224|Proteobacteria,42RAR@68525|delta/epsilon subdivisions,2WN52@28221|Deltaproteobacteria,2MAC7@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,SpoIIE
k59_1759787_1	384765.SIAM614_11383	3.34e-115	339.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2U0UY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
k59_1815948_1	1082933.MEA186_30901	1.13e-33	133.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_1408306_1	870187.Thini_2856	7.74e-48	165.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,460B0@72273|Thiotrichales	72273|Thiotrichales	T	PFAM PhoH-like protein	-	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
k59_1408306_2	1049564.TevJSym_ax00240	1.51e-09	61.2	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,1T1YP@1236|Gammaproteobacteria,1JC1F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3
k59_525111_1	383372.Rcas_3954	2.14e-77	246.0	COG0530@1|root,COG0530@2|Bacteria,2G6GV@200795|Chloroflexi,376V8@32061|Chloroflexia	32061|Chloroflexia	P	PFAM sodium calcium exchanger membrane region	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_1642151_1	314345.SPV1_13202	8.27e-109	326.0	COG0531@1|root,COG0531@2|Bacteria,1QXK2@1224|Proteobacteria	1224|Proteobacteria	E	amino acid	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	AA_permease_2
k59_1815996_1	1225184.ALXE01000038_gene3222	3.07e-19	87.8	COG3012@1|root,COG3318@1|root,COG3012@2|Bacteria,COG3318@2|Bacteria,1N0JQ@1224|Proteobacteria,1SUIC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the UPF0149 family	-	-	-	ko:K07039	-	-	-	-	ko00000	-	-	-	SEC-C,UPF0149
k59_704467_2	1500893.JQNB01000001_gene609	4.98e-16	77.4	COG4970@1|root,COG4970@2|Bacteria,1NBWI@1224|Proteobacteria,1S5MN@1236|Gammaproteobacteria,1X78Z@135614|Xanthomonadales	135614|Xanthomonadales	NU	COG4970 Tfp pilus assembly protein FimT	-	-	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspH,N_methyl
k59_1816013_2	706587.Desti_2020	9.29e-26	102.0	COG1028@1|root,COG1028@2|Bacteria,1MUAY@1224|Proteobacteria,42NIM@68525|delta/epsilon subdivisions,2WMK8@28221|Deltaproteobacteria,2MR0R@213462|Syntrophobacterales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_1170171_2	1198452.Jab_1c09890	1.17e-81	253.0	COG2972@1|root,COG2972@2|Bacteria,1QYRK@1224|Proteobacteria,2WHJ2@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Protein of unknown function (DUF3365)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HAMP
k59_1759858_1	452652.KSE_22420	1.47e-18	90.9	COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria,2M2M0@2063|Kitasatospora	201174|Actinobacteria	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_1759860_1	751994.AGIG01000034_gene616	8.95e-21	86.3	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,1S40Y@1236|Gammaproteobacteria,1JB52@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs	xdhC	-	1.2.5.3,1.3.99.16	ko:K03518,ko:K07302,ko:K13480	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	iECH74115_1262.ECH74115_4158,iECSP_1301.ECSP_3838,iECs_1301.ECs3741,iZ_1308.Z4207	Fer2,Fer2_2
k59_1057907_2	457429.ABJI02000540_gene1529	2.94e-13	71.2	COG1307@1|root,COG1307@2|Bacteria,2GIUV@201174|Actinobacteria	201174|Actinobacteria	S	DegV family	-	-	-	-	-	-	-	-	-	-	-	-	DegV
k59_1351301_1	1108045.GORHZ_055_00130	1.57e-47	163.0	2EA1Q@1|root,33470@2|Bacteria,2HCTN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DoxD
k59_941200_1	1479235.KK366039_gene2960	2.53e-18	84.7	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1XIG9@135619|Oceanospirillales	135619|Oceanospirillales	P	phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_1586000_1	1049564.TevJSym_af00240	7.4e-80	261.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1J4HR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the peptidase S16 family	ycbZ	-	-	ko:K04770	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C
k59_1527305_1	247633.GP2143_15196	7.85e-101	306.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1J4SX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	gltP	-	-	ko:K03309	-	-	-	-	ko00000	2.A.23	-	-	SDF
k59_1821702_1	396588.Tgr7_2414	1.54e-150	449.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1WWDE@135613|Chromatiales	135613|Chromatiales	T	Belongs to the PEP-utilizing enzyme family	-	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_646892_1	34007.IT40_19065	0.000165	46.2	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2TVQD@28211|Alphaproteobacteria,2PW3Q@265|Paracoccus	28211|Alphaproteobacteria	O	PPIC-type PPIASE domain	ppiC	-	5.2.1.8	ko:K01802,ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3
k59_646892_2	1123073.KB899241_gene3170	1.36e-16	79.0	COG1682@1|root,COG1682@2|Bacteria,1N0X3@1224|Proteobacteria,1RYWI@1236|Gammaproteobacteria,1X7JB@135614|Xanthomonadales	135614|Xanthomonadales	GM	Transport permease protein	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
k59_1409932_1	566466.NOR53_1444	1.86e-85	268.0	COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,1RN78@1236|Gammaproteobacteria,1J840@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	iJN746.PP_2845	Amidohydro_1,Urease_alpha
k59_177217_1	247634.GPB2148_366	1.19e-77	241.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1J5A9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	ATPases involved in chromosome partitioning	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_177217_2	1268239.PALB_22130	8.57e-10	60.5	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,2Q1CH@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_1057934_1	996637.SGM_2115	1.06e-26	115.0	COG0515@1|root,COG0515@2|Bacteria,2GJTV@201174|Actinobacteria	201174|Actinobacteria	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_236108_1	396588.Tgr7_1828	2.44e-49	169.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,1RNYA@1236|Gammaproteobacteria,1WW0S@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III, delta'	-	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
k59_118561_1	32049.SYNPCC7002_A2735	6.33e-10	63.9	COG0515@1|root,COG0515@2|Bacteria,1G0B6@1117|Cyanobacteria,1H2HB@1129|Synechococcus	1117|Cyanobacteria	KLT	Domain of unknown function (DUF4189)	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF4189,Pkinase
k59_588148_1	1304865.JAGF01000001_gene3547	4.35e-95	310.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,2GN09@201174|Actinobacteria,4F12G@85016|Cellulomonadaceae	201174|Actinobacteria	E	glutamate synthase alpha subunit domain protein	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_529425_1	1043493.BBLU01000002_gene1760	4.21e-10	59.7	arCOG07533@1|root,2ZF5I@2|Bacteria,2IMPX@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
k59_1527327_1	1049564.TevJSym_ab01500	5.66e-77	244.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1J4KC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_4,DNA_pol3_tau_5
k59_999266_2	1049564.TevJSym_at00190	1.39e-65	203.0	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria,1J5X0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
k59_354144_1	158500.BV97_01200	2.47e-20	98.2	COG0326@1|root,COG0326@2|Bacteria,1QWE9@1224|Proteobacteria	1224|Proteobacteria	O	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	DUF3883
k59_999267_1	497321.C664_06978	5.57e-72	229.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VI6I@28216|Betaproteobacteria,2KUW2@206389|Rhodocyclales	206389|Rhodocyclales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_529438_1	768671.ThimaDRAFT_1574	4.19e-207	583.0	COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,1RPGZ@1236|Gammaproteobacteria,1WWD2@135613|Chromatiales	135613|Chromatiales	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
k59_529438_2	391615.ABSJ01000014_gene1600	1.04e-26	101.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,1J6D5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
k59_705644_1	398720.MED217_17680	3.17e-27	116.0	COG3696@1|root,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,1IJ7V@117743|Flavobacteriia,2XI5J@283735|Leeuwenhoekiella	976|Bacteroidetes	P	MMPL family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran,OEP
k59_294623_1	28072.Nos7524_1286	3.9e-28	117.0	COG2931@1|root,COG3210@1|root,COG3291@1|root,COG3595@1|root,COG4070@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG3595@2|Bacteria,COG4070@2|Bacteria,1GHDQ@1117|Cyanobacteria,1HUA0@1161|Nostocales	1117|Cyanobacteria	Q	Domain of unknown function (DUF4114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114
k59_1821756_1	572477.Alvin_1103	2.53e-84	273.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1WVV0@135613|Chromatiales	135613|Chromatiales	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_60662_1	1255043.TVNIR_1307	1.27e-82	271.0	COG0457@1|root,COG0457@2|Bacteria,1QZTW@1224|Proteobacteria,1T54Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
k59_294628_1	1249627.D779_1617	5.51e-72	226.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales	135613|Chromatiales	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
k59_1527335_1	518766.Rmar_1473	5.54e-13	72.4	COG1309@1|root,COG1309@2|Bacteria,4NPAQ@976|Bacteroidetes,1FJF4@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
k59_1527335_2	1121035.AUCH01000022_gene3192	5.72e-139	410.0	COG2159@1|root,COG2159@2|Bacteria,1R7E1@1224|Proteobacteria,2VPY4@28216|Betaproteobacteria,2KVED@206389|Rhodocyclales	206389|Rhodocyclales	S	Amidohydrolase	uxuA	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_1527335_3	159087.Daro_2879	1.29e-70	216.0	COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,2VRAZ@28216|Betaproteobacteria,2KWM5@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the UPF0178 family	-	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
k59_1762200_1	383372.Rcas_1559	4.1e-45	159.0	COG0460@1|root,COG0460@2|Bacteria,2G6PU@200795|Chloroflexi,376TN@32061|Chloroflexia	32061|Chloroflexia	C	PFAM homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
k59_705656_1	709986.Deima_0512	5.71e-56	191.0	COG2986@1|root,COG2986@2|Bacteria,1WISU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM Phenylalanine and histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
k59_470737_1	56780.SYN_02126	1.28e-64	209.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,2MQ79@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	nifS-1	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_470737_2	269799.Gmet_0991	0.00036	43.1	COG0694@1|root,COG0822@1|root,COG1251@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,COG1251@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2WJBU@28221|Deltaproteobacteria,43U7A@69541|Desulfuromonadales	28221|Deltaproteobacteria	CO	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins	nifU	-	-	ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
k59_1541_1	367299.JOEE01000008_gene444	3.27e-96	286.0	2AIF4@1|root,318WM@2|Bacteria,2GK8R@201174|Actinobacteria,4FG7B@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3000)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3000
k59_588189_1	367299.JOEE01000011_gene3189	5.42e-140	412.0	COG1217@1|root,COG1217@2|Bacteria,2GJUJ@201174|Actinobacteria,4FEJF@85021|Intrasporangiaceae	201174|Actinobacteria	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_882593_1	105559.Nwat_1567	4.87e-17	78.6	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1WYRM@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_1242613_1	1479239.JQMU01000001_gene2411	5.48e-45	161.0	COG3540@1|root,COG3540@2|Bacteria,1R5RU@1224|Proteobacteria,2U4KZ@28211|Alphaproteobacteria,2K8XM@204457|Sphingomonadales	204457|Sphingomonadales	P	PhoD-like phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	PhoD
k59_595131_1	1198232.CYCME_0690	3.31e-17	80.5	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,1RNN4@1236|Gammaproteobacteria,45ZSA@72273|Thiotrichales	72273|Thiotrichales	O	PFAM Carbamoyltransferase	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
k59_595131_2	1132855.KB913035_gene919	8.49e-12	68.6	COG1718@1|root,COG1718@2|Bacteria,1QY37@1224|Proteobacteria,2VKUD@28216|Betaproteobacteria,2KKE5@206350|Nitrosomonadales	206350|Nitrosomonadales	DT	Lipopolysaccharide kinase (Kdo/WaaP) family	-	-	-	-	-	-	-	-	-	-	-	-	Kdo
k59_1592636_1	318167.Sfri_2291	1.56e-75	251.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,2QAEU@267890|Shewanellaceae	1236|Gammaproteobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_1652413_1	1123401.JHYQ01000020_gene956	1.29e-71	233.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,46032@72273|Thiotrichales	72273|Thiotrichales	P	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
k59_70816_1	1122603.ATVI01000008_gene2466	1.56e-39	143.0	COG0406@1|root,COG0406@2|Bacteria,1RB0S@1224|Proteobacteria,1SAC4@1236|Gammaproteobacteria,1XBXM@135614|Xanthomonadales	135614|Xanthomonadales	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_70816_2	1397527.Q670_11845	2.69e-06	49.3	COG4221@1|root,COG4221@2|Bacteria,1QVS5@1224|Proteobacteria,1T2IN@1236|Gammaproteobacteria,1XJRH@135619|Oceanospirillales	135619|Oceanospirillales	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_951533_1	1254432.SCE1572_38865	4.72e-28	115.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1R7WZ@1224|Proteobacteria,42Q3R@68525|delta/epsilon subdivisions,2WM5A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	SMART protein phosphatase 2C domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,SSF,SpoIIE
k59_1768759_2	1133849.O3I_017615	8.5e-40	143.0	COG1960@1|root,COG1960@2|Bacteria,2GVSU@201174|Actinobacteria,4G61E@85025|Nocardiaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K11731	ko00281,map00281	-	R08089	RC01893	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1122449_1	1454010.JEOE01000008_gene1851	6.83e-171	501.0	COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria	201174|Actinobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_1417651_1	1123503.KB908058_gene746	0.000899	41.2	COG0711@1|root,COG0711@2|Bacteria,1MZGU@1224|Proteobacteria,2UBVW@28211|Alphaproteobacteria,2KGUT@204458|Caulobacterales	204458|Caulobacterales	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
k59_1417651_2	744985.HIMB59_00007670	1.81e-28	103.0	COG0636@1|root,COG0636@2|Bacteria,1MZBU@1224|Proteobacteria,2UFPN@28211|Alphaproteobacteria,4BQV8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_595145_1	1449126.JQKL01000011_gene3550	1.73e-15	80.1	COG0247@1|root,COG0247@2|Bacteria,1UZQ0@1239|Firmicutes,24E5H@186801|Clostridia	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17
k59_13449_1	1353528.DT23_04175	3.28e-15	80.9	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2TS8U@28211|Alphaproteobacteria,2XM4H@285107|Thioclava	28211|Alphaproteobacteria	I	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
k59_477853_1	296591.Bpro_4149	4.75e-96	308.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VKRS@28216|Betaproteobacteria,4AAXQ@80864|Comamonadaceae	28216|Betaproteobacteria	T	His Kinase A (phospho-acceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
k59_830072_1	330214.NIDE0496	3.71e-44	158.0	COG2379@1|root,COG2379@2|Bacteria,3J16T@40117|Nitrospirae	40117|Nitrospirae	H	MOFRL family	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
k59_1768779_1	314256.OG2516_18440	2.62e-42	158.0	COG2931@1|root,COG3210@1|root,COG4070@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria,2V8V8@28211|Alphaproteobacteria,2PFGF@252301|Oceanicola	28211|Alphaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_247175_1	1380347.JNII01000007_gene381	1.42e-33	135.0	COG3858@1|root,COG5479@1|root,COG3858@2|Bacteria,COG5479@2|Bacteria,2GNDB@201174|Actinobacteria,4ESE3@85013|Frankiales	201174|Actinobacteria	M	Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme.	csp	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,LGFP
k59_536686_1	1304888.ATWF01000002_gene296	4.26e-08	58.2	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_892575_1	502025.Hoch_1234	3.12e-57	200.0	COG1293@1|root,COG1293@2|Bacteria,1QUKW@1224|Proteobacteria,42T1A@68525|delta/epsilon subdivisions,2WR1H@28221|Deltaproteobacteria,2YW1R@29|Myxococcales	68525|delta/epsilon subdivisions	K	RNA-binding protein homologous to eukaryotic snRNP	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1534298_2	446466.Cfla_2069	1.29e-145	419.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria,4F1YY@85016|Cellulomonadaceae	201174|Actinobacteria	GK	ROK family	glkA	GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044464,GO:0046835,GO:0051156,GO:0071704,GO:1901135	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_1534298_3	446471.Xcel_2001	2.55e-21	92.4	2DQFV@1|root,336KJ@2|Bacteria,2I0MX@201174|Actinobacteria,4F4WP@85017|Promicromonosporaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1534298_4	471853.Bcav_1904	1.12e-25	101.0	COG0204@1|root,COG0204@2|Bacteria,2GJ6V@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_247194_2	1101195.Meth11DRAFT_2120	4.19e-51	176.0	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,2W9RF@28216|Betaproteobacteria,2KNR5@206350|Nitrosomonadales	206350|Nitrosomonadales	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_125872_1	187272.Mlg_2774	4.11e-38	144.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales	135613|Chromatiales	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_125872_2	2325.TKV_c18920	1.36e-29	116.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,42EZ0@68295|Thermoanaerobacterales	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1,5.1.1.18	ko:K01775,ko:K18348	ko00473,ko01100,ko01502,ko02020,map00473,map01100,map01502,map02020	M00652	R00401	RC00285	ko00000,ko00001,ko00002,ko01000,ko01011,ko01504	-	-	-	Acyl_transf_3,Ala_racemase_C,Ala_racemase_N
k59_1831900_1	767029.HMPREF9154_0821	2.71e-82	253.0	COG2896@1|root,COG2896@2|Bacteria,2GN0V@201174|Actinobacteria,4DP3D@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
k59_1831900_2	479433.Caci_8251	9.67e-09	53.1	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	moaD	-	2.8.1.12	ko:K03636,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
k59_951588_1	261292.Nit79A3_3206	2.36e-117	342.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2VKP0@28216|Betaproteobacteria,372US@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Protein of unknown function (DUF692)	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
k59_830091_1	290399.Arth_0897	2.79e-24	97.8	COG0662@1|root,COG0662@2|Bacteria,2IKT6@201174|Actinobacteria	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_1303797_1	1197706.AKKK01000047_gene3292	1.25e-40	152.0	COG1940@1|root,COG1940@2|Bacteria,2GNFJ@201174|Actinobacteria	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,ROK
k59_125881_1	926569.ANT_18640	5.64e-78	254.0	COG3808@1|root,COG3808@2|Bacteria,2G5N7@200795|Chloroflexi	200795|Chloroflexi	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_712909_1	1042375.AFPL01000032_gene899	2.66e-15	71.6	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,1RU3J@1236|Gammaproteobacteria,46BFD@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Sulfur oxidation protein SoxY	-	-	-	-	-	-	-	-	-	-	-	-	SoxY
k59_712909_2	1268622.AVS7_01211	1.38e-36	126.0	COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,2VU95@28216|Betaproteobacteria,4AEQV@80864|Comamonadaceae	28216|Betaproteobacteria	S	Sulphur oxidation protein SoxZ	soxZ	-	-	ko:K17227	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxZ
k59_712909_3	1415754.JQMK01000013_gene117	1.85e-41	144.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,1RS6A@1236|Gammaproteobacteria,469SU@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	C-type monoheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the intermediary formation of conspicuous sulfur globules inside of the cells	soxA	-	1.8.2.2	ko:K17222,ko:K19713	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	-	-	-	-
k59_536707_1	644801.Psest_1321	1.1e-87	267.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,1RQQT@1236|Gammaproteobacteria,1Z1FE@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
k59_1831914_1	237727.NAP1_03750	8.86e-65	225.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2KCZ7@204457|Sphingomonadales	204457|Sphingomonadales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1303803_1	1437882.AZRU01000050_gene5318	1.74e-44	157.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,1YFBF@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_892601_2	1283300.ATXB01000001_gene817	6.9e-84	262.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,1XEM7@135618|Methylococcales	135618|Methylococcales	E	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
k59_419043_1	1415780.JPOG01000001_gene1075	4.78e-182	546.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,1RSHX@1236|Gammaproteobacteria,1X3T3@135614|Xanthomonadales	135614|Xanthomonadales	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_70884_1	981384.AEYW01000016_gene19	1.17e-43	159.0	COG3659@1|root,COG3659@2|Bacteria,1R8TI@1224|Proteobacteria,2URIQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Carbohydrate-selective porin, OprB family	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB
k59_70884_2	981384.AEYW01000004_gene1771	2.64e-11	64.7	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1768806_1	1089546.AQUI01000002_gene3659	6.47e-22	94.7	COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria,408NI@622450|Actinopolysporales	201174|Actinobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_1831920_1	493475.GARC_2259	1.46e-74	240.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,1RMCN@1236|Gammaproteobacteria,4650I@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG0659 Sulfate permease and related transporters (MFS superfamily)	dauA_1	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1067207_2	1249627.D779_1392	4.51e-27	109.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1WVWH@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_1592699_1	768671.ThimaDRAFT_1211	3.56e-115	372.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon
k59_477891_1	1244869.H261_05794	4.67e-31	122.0	COG4269@1|root,COG4269@2|Bacteria,1MW5P@1224|Proteobacteria,2U0EV@28211|Alphaproteobacteria,2JTAG@204441|Rhodospirillales	204441|Rhodospirillales	S	Bacterial protein of unknown function (DUF898)	-	-	-	-	-	-	-	-	-	-	-	-	DUF898
k59_654219_1	572477.Alvin_1387	1.84e-116	344.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1WWEM@135613|Chromatiales	135613|Chromatiales	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_830119_1	469383.Cwoe_3510	6.83e-74	234.0	COG0743@1|root,COG0743@2|Bacteria,2GIRV@201174|Actinobacteria,4CPQ0@84995|Rubrobacteria	84995|Rubrobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_1358381_2	1120792.JAFV01000001_gene3539	2.27e-30	127.0	COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,2TT33@28211|Alphaproteobacteria,36ZVJ@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Phage portal protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_portal
k59_1831934_2	1454010.JEOE01000009_gene3054	1.57e-74	226.0	COG0590@1|root,COG0590@2|Bacteria,2IM3Z@201174|Actinobacteria,4F1B3@85016|Cellulomonadaceae	201174|Actinobacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.1,3.5.4.33	ko:K01485,ko:K11991	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922,R10223	RC00074,RC00477,RC00514,RC00809	ko00000,ko00001,ko01000,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
k59_1652500_1	1187851.A33M_0944	1.08e-61	207.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria,3FCYB@34008|Rhodovulum	28211|Alphaproteobacteria	O	Peptidase M16 inactive domain	MA20_05655	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_125907_1	1052684.PPM_4596	2.67e-15	82.0	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,4HAFP@91061|Bacilli,26SD1@186822|Paenibacillaceae	91061|Bacilli	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	acrB1	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_536730_1	1049564.TevJSym_ab00170	1e-62	204.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,1S03J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Major facilitator superfamily	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_247263_1	1095772.CAHH01000015_gene1037	9.59e-50	170.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase	aspB	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_247263_2	1206101.AZXC01000009_gene552	9.96e-27	100.0	COG3602@1|root,COG3602@2|Bacteria,2IM16@201174|Actinobacteria	201174|Actinobacteria	S	ACT domain	-	-	-	ko:K09964	-	-	-	-	ko00000	-	-	-	ACT_3,ACT_7,Acetyltransf_1
k59_712932_1	472759.Nhal_3797	1.15e-95	292.0	COG2807@1|root,COG2807@2|Bacteria,1QW3Y@1224|Proteobacteria,1T2RW@1236|Gammaproteobacteria,1X2P1@135613|Chromatiales	135613|Chromatiales	P	PFAM Major Facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
k59_1303837_1	1048339.KB913029_gene295	1.17e-117	342.0	COG2801@1|root,COG2801@2|Bacteria,2GKDY@201174|Actinobacteria,4ESNN@85013|Frankiales	201174|Actinobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_951634_1	305900.GV64_15180	4.82e-152	436.0	28HAQ@1|root,2Z7N0@2|Bacteria,1N5R2@1224|Proteobacteria,1RNKD@1236|Gammaproteobacteria,1XNW3@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_951634_2	1454004.AW11_02613	1.13e-44	148.0	2CNK3@1|root,32SH9@2|Bacteria,1N02U@1224|Proteobacteria,2VUNW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of Unknown function (DUF2784)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2784
k59_951634_3	1323663.AROI01000031_gene1917	3.84e-55	172.0	COG3461@1|root,COG3461@2|Bacteria,1MZZN@1224|Proteobacteria,1S688@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	ko:K09700	-	-	-	-	ko00000	-	-	-	-
k59_184632_1	227377.CBU_1544	9.64e-64	208.0	COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,1JEXQ@118969|Legionellales	118969|Legionellales	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_1592718_1	1262449.CP6013_1280	1.71e-104	319.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2485A@186801|Clostridia,36DJ6@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,HTH_18,LeuA_dimer
k59_248316_2	999549.KI421514_gene289	1.04e-33	128.0	COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2TSUS@28211|Alphaproteobacteria,2828R@191028|Leisingera	28211|Alphaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
k59_419594_1	1333856.L686_19345	2.02e-89	286.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1Z1CH@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_185258_1	1122194.AUHU01000007_gene104	1.07e-61	202.0	COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,1RQHX@1236|Gammaproteobacteria,46503@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Rossmann fold nucleotide-binding protein	ygdH	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016798,GO:0016799,GO:0044424,GO:0044444,GO:0044464,GO:0047405	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DUF3412,DUF4478,Lysine_decarbox
k59_713551_1	768671.ThimaDRAFT_2746	1.25e-160	466.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1WX77@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
k59_71716_1	439235.Dalk_3266	2.2e-23	99.4	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_1358881_1	471853.Bcav_2161	8.23e-155	457.0	COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_478445_1	266940.Krad_1151	1.07e-89	269.0	COG1595@1|root,COG1595@2|Bacteria,2GK4C@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigE	GO:0000302,GO:0000988,GO:0000990,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0043207,GO:0043254,GO:0044087,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0090034,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_478445_2	1454010.JEOE01000020_gene2610	8.26e-31	125.0	COG5662@1|root,COG5662@2|Bacteria,2HY0V@201174|Actinobacteria,4F2E6@85016|Cellulomonadaceae	201174|Actinobacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
k59_478445_3	1033736.CAHK01000052_gene1194	8.66e-08	55.1	COG1826@1|root,COG1826@2|Bacteria,2IR0U@201174|Actinobacteria,4FA13@85019|Brevibacteriaceae	201174|Actinobacteria	U	mttA/Hcf106 family	tatB	GO:0008150,GO:0040007	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_713556_1	420662.Mpe_A0069	8.38e-21	92.4	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,1KJ47@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KLT	PFAM Protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE2,Pkinase
k59_713556_2	426114.THI_0772	6.92e-45	162.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,1KIWT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
k59_830696_2	690597.JH730961_gene4525	1.08e-56	193.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1YNC6@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	J	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	GO:0002097,GO:0002101,GO:0002136,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016879,GO:0032267,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
k59_1418300_1	84531.JMTZ01000085_gene1357	2.7e-78	253.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1X3IW@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_14624_1	1121405.dsmv_0269	1.29e-11	65.5	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
k59_537290_1	1121362.A605_03595	2.28e-24	107.0	COG3385@1|root,COG3385@2|Bacteria,2H68X@201174|Actinobacteria,22MSP@1653|Corynebacteriaceae	201174|Actinobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_1304653_1	1232410.KI421419_gene2503	7.54e-112	329.0	COG1313@1|root,COG1313@2|Bacteria,1NZAK@1224|Proteobacteria,42NYF@68525|delta/epsilon subdivisions,2WIT2@28221|Deltaproteobacteria,43SFJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Radical_SAM
k59_1478549_1	1255043.TVNIR_3803	7.53e-91	285.0	COG1269@1|root,COG1269@2|Bacteria,1QGFB@1224|Proteobacteria,1RQRW@1236|Gammaproteobacteria,1WWNC@135613|Chromatiales	135613|Chromatiales	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_126573_1	1132855.KB913035_gene1470	8.64e-71	226.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2VIQW@28216|Betaproteobacteria,2KKT3@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
k59_1363428_1	794903.OPIT5_16815	2.5e-90	288.0	COG1048@1|root,COG1048@2|Bacteria,46SFS@74201|Verrucomicrobia,3K7UQ@414999|Opitutae	414999|Opitutae	C	Aconitase family (aconitate hydratase)	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_1839195_2	479434.Sthe_2315	6.82e-49	169.0	COG2855@1|root,COG2855@2|Bacteria,2G98G@200795|Chloroflexi	200795|Chloroflexi	S	Conserved hypothetical protein 698	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
k59_1657868_1	1123261.AXDW01000003_gene1861	8.97e-26	111.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1X3SF@135614|Xanthomonadales	135614|Xanthomonadales	U	Type II secretory pathway, component HofQ	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_1657868_2	1123261.AXDW01000003_gene1862	4.88e-12	63.2	COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,1S6VJ@1236|Gammaproteobacteria,1X61Y@135614|Xanthomonadales	135614|Xanthomonadales	NU	pilus assembly protein pilp	pilP	-	-	ko:K02665	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilP
k59_958828_1	1386089.N865_07215	8.32e-120	361.0	COG1926@1|root,COG2312@1|root,COG1926@2|Bacteria,COG2312@2|Bacteria,2GJUU@201174|Actinobacteria	201174|Actinobacteria	Q	phosphoribosyltransferase	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Erythro_esteras,Pribosyltran
k59_1250061_1	1218084.BBJK01000120_gene6892	2.54e-90	296.0	COG0439@1|root,COG1984@1|root,COG2049@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,1MU4H@1224|Proteobacteria,2WGI2@28216|Betaproteobacteria,1K3CB@119060|Burkholderiaceae	28216|Betaproteobacteria	EI	urea carboxylase	uca	-	6.3.4.6	ko:K01941	ko00220,ko00791,ko01100,map00220,map00791,map01100	-	R00774	RC00378	ko00000,ko00001,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D
k59_899843_1	1210046.B277_09902	1.91e-74	231.0	COG0363@1|root,COG0363@2|Bacteria,2GMQ2@201174|Actinobacteria,4FEN6@85021|Intrasporangiaceae	201174|Actinobacteria	G	6-phosphogluconolactonase	pgl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:1901135,GO:1901360,GO:1901564	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
k59_483014_1	446466.Cfla_1508	8.13e-79	247.0	COG0195@1|root,COG0195@2|Bacteria,2GJDJ@201174|Actinobacteria,4F0JV@85016|Cellulomonadaceae	201174|Actinobacteria	K	Participates in both transcription termination and antitermination	nusA	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0040007,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
k59_1597784_1	1198452.Jab_2c01520	1.8e-110	342.0	COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,4736W@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
k59_835408_1	1121935.AQXX01000141_gene2012	1.54e-60	195.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,1RPBB@1236|Gammaproteobacteria,1XIQ5@135619|Oceanospirillales	135619|Oceanospirillales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
k59_1839223_1	645127.ckrop_1943	2.49e-48	174.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,22KEE@1653|Corynebacteriaceae	201174|Actinobacteria	P	cation transport ATPase	copB	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686,ko:K21887	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3,3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
k59_600064_1	342610.Patl_2901	6.82e-06	50.1	COG3767@1|root,COG3767@2|Bacteria,1N9HK@1224|Proteobacteria,1SD4Q@1236|Gammaproteobacteria,2Q1NP@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_600064_2	713586.KB900536_gene2708	4.66e-25	100.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,1RQ9H@1236|Gammaproteobacteria,1WWJ1@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0276 family	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
k59_835416_1	595593.JREV01000020_gene2063	1.72e-52	190.0	COG1674@1|root,COG1716@1|root,COG1674@2|Bacteria,COG1716@2|Bacteria,2GJBR@201174|Actinobacteria,1W7X5@1268|Micrococcaceae	201174|Actinobacteria	DT	FtsK/SpoIIIE family	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_SpoIIIE,Yop-YscD_cpl
k59_78028_1	177437.HRM2_44680	5.87e-18	85.9	COG4974@1|root,COG4974@2|Bacteria,1NY1A@1224|Proteobacteria,42NX3@68525|delta/epsilon subdivisions,2WME4@28221|Deltaproteobacteria,2MPJH@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_372650_1	1121935.AQXX01000135_gene3757	1.63e-59	196.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1S1W6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
k59_1598477_1	159087.Daro_2711	6e-53	185.0	COG0810@1|root,COG1193@1|root,COG3064@1|root,COG0810@2|Bacteria,COG1193@2|Bacteria,COG3064@2|Bacteria,1REKC@1224|Proteobacteria,2VRYT@28216|Betaproteobacteria	28216|Betaproteobacteria	M	TonB C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_2
k59_1250966_1	1276756.AUEX01000015_gene1996	2.65e-161	464.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VIYF@28216|Betaproteobacteria,4AAS7@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM carboxyl transferase	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1540143_1	95619.PM1_0204980	5.45e-86	266.0	COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	dna polymerase III delta subunit	holA	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delt_C,DNA_pol3_delta
k59_372656_2	1430440.MGMSRv2_3272	4.33e-59	201.0	COG0726@1|root,COG0726@2|Bacteria,1MWR2@1224|Proteobacteria,2V6MG@28211|Alphaproteobacteria,2JQTK@204441|Rhodospirillales	204441|Rhodospirillales	G	xylanase chitin deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
k59_79063_1	479433.Caci_1953	1.85e-33	134.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria	201174|Actinobacteria	F	Drug exporters of the RND superfamily	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
k59_959905_1	1123392.AQWL01000003_gene280	2.56e-53	186.0	28K74@1|root,2Z9VA@2|Bacteria,1R8MQ@1224|Proteobacteria,2VZJU@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_600796_1	1304865.JAGF01000001_gene385	1.58e-32	127.0	COG2366@1|root,COG2366@2|Bacteria,2GISQ@201174|Actinobacteria,4F0SH@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_600796_2	888050.HMPREF9004_0568	7.44e-22	91.3	COG0212@1|root,COG0212@2|Bacteria,2IKWR@201174|Actinobacteria,4D33A@85005|Actinomycetales	201174|Actinobacteria	H	5-formyltetrahydrofolate cyclo-ligase	ygfA	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
k59_483731_1	56780.SYN_01984	3.62e-63	201.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,42N0I@68525|delta/epsilon subdivisions,2WMUX@28221|Deltaproteobacteria,2MQHN@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
k59_660443_1	1304865.JAGF01000001_gene3099	5.32e-98	296.0	COG0446@1|root,COG0446@2|Bacteria,2GRTN@201174|Actinobacteria	201174|Actinobacteria	P	pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DsrC,Pyr_redox_2
k59_542556_1	717785.HYPMC_2872	6.97e-120	349.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2TRXE@28211|Alphaproteobacteria,3N699@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_1485987_1	880072.Desac_2454	2.27e-08	54.3	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,42U68@68525|delta/epsilon subdivisions,2WQJS@28221|Deltaproteobacteria,2MQQN@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
k59_1540159_1	472759.Nhal_0256	2.37e-94	284.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,1WWEI@135613|Chromatiales	135613|Chromatiales	H	PFAM UBA THIF-type NAD FAD binding	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
k59_1774512_2	1049564.TevJSym_aq00110	8.45e-155	460.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1J4DP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378	DALR_1,tRNA_synt_2f
k59_1076600_2	59538.XP_005974149.1	7.17e-27	111.0	COG0458@1|root,KOG0370@2759|Eukaryota,38CAC@33154|Opisthokonta,3B9FF@33208|Metazoa,3CS9A@33213|Bilateria,4804V@7711|Chordata,490QX@7742|Vertebrata,3J7SX@40674|Mammalia	33208|Metazoa	F	aspartate binding	Cad	-	2.1.3.2,3.5.2.3,6.3.5.5	ko:K11540	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R01397,R01993,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00632,RC02750,RC02798,RC02850,RC03314	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Amidohydro_1,CPSase_L_D2,CPSase_L_D3,CPSase_sm_chain,GATase,MGS,OTCace,OTCace_N
k59_959931_1	426117.M446_1342	5.04e-19	87.8	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2TR5X@28211|Alphaproteobacteria,1JZ5G@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Peptidase family M28	amaB	GO:0003674,GO:0005488,GO:0005515,GO:0042802	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1540167_1	477974.Daud_1072	9.33e-70	220.0	COG1313@1|root,COG1313@2|Bacteria,1TRUV@1239|Firmicutes,247VW@186801|Clostridia,2613G@186807|Peptococcaceae	186801|Clostridia	C	radical SAM domain protein	PflX	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
k59_1364226_1	768671.ThimaDRAFT_1821	2.01e-83	268.0	COG1680@1|root,COG1680@2|Bacteria,1PGQT@1224|Proteobacteria,1SWR7@1236|Gammaproteobacteria,1X19R@135613|Chromatiales	135613|Chromatiales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_424995_1	1394178.AWOO02000041_gene8777	0.000326	46.6	COG1670@1|root,COG1670@2|Bacteria,2IQW2@201174|Actinobacteria,4EJRW@85012|Streptosporangiales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006104,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_424995_2	686340.Metal_2274	4.99e-09	58.9	COG2885@1|root,COG2911@1|root,COG2982@1|root,COG2885@2|Bacteria,COG2911@2|Bacteria,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,1RNPC@1236|Gammaproteobacteria,1XE60@135618|Methylococcales	135618|Methylococcales	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
k59_1188889_1	1146883.BLASA_1050	6.53e-16	75.1	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4EV2Q@85013|Frankiales	201174|Actinobacteria	K	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1188889_2	67267.JNXT01000002_gene6169	1.08e-33	131.0	COG4585@1|root,COG4585@2|Bacteria,2I8C1@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_719025_1	322710.Avin_42650	3.64e-55	183.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,1RMYQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	GO:0000166,GO:0002097,GO:0003674,GO:0005488,GO:0005524,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
k59_959938_1	1304865.JAGF01000001_gene1621	5.4e-88	279.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4F0UZ@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
k59_1840309_1	1353537.TP2_00585	1.79e-17	92.0	COG0771@1|root,COG2911@1|root,COG2931@1|root,COG4625@1|root,COG4935@1|root,COG0771@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,COG4935@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,DUF4214,HemolysinCabind,Hint_2
k59_1485998_1	1122609.AUGT01000003_gene2318	5.01e-72	235.0	COG3848@1|root,COG3848@2|Bacteria,2I3FP@201174|Actinobacteria,4DVNT@85009|Propionibacteriales	201174|Actinobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
k59_1540180_1	648996.Theam_0110	1.13e-28	116.0	COG2074@1|root,COG2074@2|Bacteria,2G4F4@200783|Aquificae	200783|Aquificae	G	ATP cone domain	-	-	-	ko:K05715	-	-	R02664	RC00002,RC00017	ko00000,ko01000	-	-	-	ATP-cone
k59_660470_1	1035308.AQYY01000001_gene1989	3.18e-88	270.0	COG0624@1|root,COG0624@2|Bacteria	2|Bacteria	E	succinyl-diaminopimelate desuccinylase activity	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_542576_1	743836.AYNA01000121_gene2519	2.98e-91	275.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,36XYF@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	ppk2	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008976,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0044237	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
k59_1312133_1	572477.Alvin_2794	7.63e-42	153.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1WVX9@135613|Chromatiales	135613|Chromatiales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_425005_1	768671.ThimaDRAFT_2904	2.25e-112	335.0	COG5557@1|root,COG5557@2|Bacteria,1MXP7@1224|Proteobacteria,1RS7Z@1236|Gammaproteobacteria,1WX2A@135613|Chromatiales	135613|Chromatiales	C	PFAM Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_1010030_1	396588.Tgr7_2024	4.03e-76	248.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1WX4B@135613|Chromatiales	135613|Chromatiales	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_1716134_1	555778.Hneap_0228	1.79e-41	147.0	COG0561@1|root,COG0561@2|Bacteria,1QDJR@1224|Proteobacteria,1RSEI@1236|Gammaproteobacteria,1WX4S@135613|Chromatiales	135613|Chromatiales	S	HAD-superfamily hydrolase, subfamily IIB	-	-	-	-	-	-	-	-	-	-	-	-	S6PP,YcgL
k59_79136_1	395493.BegalDRAFT_0529	7.87e-25	98.2	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria	1224|Proteobacteria	U	general secretion pathway protein G	gspG2	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
k59_900993_1	861299.J421_3545	2.54e-73	237.0	COG2987@1|root,COG2987@2|Bacteria,1ZSQX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
k59_900996_1	998674.ATTE01000001_gene479	7.91e-23	97.4	COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria,4613W@72273|Thiotrichales	72273|Thiotrichales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
k59_900996_2	416269.APL_0022	7.27e-06	47.4	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1Y7FF@135625|Pasteurellales	135625|Pasteurellales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0032153,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0098552,GO:0098562	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_1312155_1	439235.Dalk_0804	7.52e-39	142.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,2MHTP@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1276	CTP_synth_N,GATase
k59_1312155_2	1121405.dsmv_0791	3.49e-12	66.6	COG1651@1|root,COG1651@2|Bacteria,1RKYF@1224|Proteobacteria,42T64@68525|delta/epsilon subdivisions,2WP82@28221|Deltaproteobacteria,2MNDC@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
k59_425019_1	1042375.AFPL01000032_gene902	2.67e-115	344.0	COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,1RP2M@1236|Gammaproteobacteria,46AFY@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Mo-co oxidoreductase dimerisation domain	-	-	-	ko:K17225	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Mo-co_dimer,Oxidored_molyb
k59_719058_1	713586.KB900536_gene3045	8.23e-12	65.5	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,1S2ET@1236|Gammaproteobacteria,1WWDD@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_600849_1	580332.Slit_2777	2.84e-128	381.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,2VMUK@28216|Betaproteobacteria	28216|Betaproteobacteria	O	serine protease	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
k59_542600_1	351348.Maqu_0966	2.82e-131	384.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,465C7@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Belongs to the aspartokinase family	lysC	GO:0003674,GO:0003824,GO:0004072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0044237	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
k59_1540208_1	326298.Suden_1813	4.32e-153	446.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2YQN3@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_901003_1	1502852.FG94_04436	2.08e-23	90.1	COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2VW58@28216|Betaproteobacteria,4752V@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Belongs to the UPF0434 family	ycaR	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
k59_901003_2	1049564.TevJSym_al00460	3.12e-116	347.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1J5MP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009029,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iBWG_1329.BWG_0767,iECDH10B_1368.ECDH10B_0985,iPC815.YPO1396	LpxK
k59_1010045_1	371731.Rsw2DRAFT_3304	4.92e-47	155.0	COG2210@1|root,COG2210@2|Bacteria,1RDUG@1224|Proteobacteria,2U6FZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
k59_1598558_1	572477.Alvin_1433	2.27e-44	162.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,1WWAN@135613|Chromatiales	135613|Chromatiales	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_600854_1	278957.ABEA03000060_gene3093	4.86e-123	362.0	COG0468@1|root,COG0468@2|Bacteria,46SIZ@74201|Verrucomicrobia,3K737@414999|Opitutae	414999|Opitutae	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_1658757_1	1198232.CYCME_0531	1.05e-06	51.2	COG2433@1|root,COG2433@2|Bacteria,1R1QS@1224|Proteobacteria,1T58I@1236|Gammaproteobacteria,463VZ@72273|Thiotrichales	72273|Thiotrichales	S	Domain of unknown function (DUF4124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124
k59_1540215_1	765911.Thivi_3496	2.06e-45	155.0	COG3440@1|root,COG3440@2|Bacteria,1QMZS@1224|Proteobacteria,1RWDA@1236|Gammaproteobacteria,1WZFC@135613|Chromatiales	135613|Chromatiales	V	Restriction endonuclease	-	-	-	ko:K07454	-	-	-	-	ko00000	-	-	-	HNH_2
k59_660502_1	570967.JMLV01000009_gene1084	2.42e-86	274.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TXAW@28211|Alphaproteobacteria,2JRIA@204441|Rhodospirillales	204441|Rhodospirillales	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_307589_1	1123261.AXDW01000007_gene2232	5.61e-139	402.0	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,1RMRY@1236|Gammaproteobacteria,1X4SK@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
k59_190829_1	1123393.KB891326_gene128	5.05e-86	260.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,2VJKH@28216|Betaproteobacteria,1KSKW@119069|Hydrogenophilales	119069|Hydrogenophilales	KO	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
k59_1076675_1	926569.ANT_13140	2.02e-39	138.0	COG1595@1|root,COG1595@2|Bacteria,2G6T5@200795|Chloroflexi	200795|Chloroflexi	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_542612_1	671143.DAMO_0507	1.62e-79	245.0	COG0462@1|root,COG0462@2|Bacteria,2NNP6@2323|unclassified Bacteria	2|Bacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2848	Pribosyl_synth,Pribosyltran_N
k59_719071_1	95619.PM1_0203270	5.03e-294	816.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_960010_2	519989.ECTPHS_13203	4.2e-211	601.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1WW0N@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1127679_1	1380394.JADL01000003_gene5176	2.97e-54	186.0	COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2TS1C@28211|Alphaproteobacteria,2JPFT@204441|Rhodospirillales	204441|Rhodospirillales	S	Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
k59_79178_1	335543.Sfum_0540	2.25e-66	232.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,42MKN@68525|delta/epsilon subdivisions,2WJV6@28221|Deltaproteobacteria,2MQHQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Secretin and TonB N terminus short domain	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_307599_1	1231391.AMZF01000060_gene1340	3.96e-79	254.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2VHBQ@28216|Betaproteobacteria,3T2Q4@506|Alcaligenaceae	28216|Betaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_1010059_1	572477.Alvin_0800	3.7e-30	121.0	COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1WWFZ@135613|Chromatiales	135613|Chromatiales	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase
k59_1658774_1	1122194.AUHU01000004_gene1370	7.49e-82	259.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,4664R@72275|Alteromonadaceae	1236|Gammaproteobacteria	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_1840397_1	1217718.ALOU01000038_gene3393	3.78e-58	192.0	COG3181@1|root,COG3181@2|Bacteria,1R7CA@1224|Proteobacteria,2VPK1@28216|Betaproteobacteria,1KCA0@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_1774584_1	565045.NOR51B_478	6.26e-149	432.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,1J5CE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
k59_483816_1	1120941.AUBL01000077_gene1498	1.12e-29	115.0	COG0491@1|root,COG0491@2|Bacteria,2GJU0@201174|Actinobacteria,4D4N8@85005|Actinomycetales	201174|Actinobacteria	S	Metallo-beta-lactamase domain protein	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
k59_1256981_2	1276920.ADIAG_00434	1.61e-38	144.0	COG1073@1|root,COG1073@2|Bacteria,2IHUE@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_5
k59_1491639_1	1121405.dsmv_1445	1.52e-71	233.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2MI6Q@213118|Desulfobacterales	28221|Deltaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_1318685_1	713587.THITH_09725	1.94e-68	213.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,1RMMG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
k59_1846854_2	1027273.GZ77_22955	5.37e-113	330.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1XI8X@135619|Oceanospirillales	135619|Oceanospirillales	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
k59_1720930_1	864069.MicloDRAFT_00010680	1.41e-49	171.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,1JRXN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM transposase mutator type	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_779056_1	1121875.KB907548_gene1629	5.29e-46	165.0	COG0668@1|root,COG0668@2|Bacteria,4NHU7@976|Bacteroidetes,1I0RF@117743|Flavobacteriia	976|Bacteroidetes	M	Mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
k59_1491645_1	96561.Dole_2111	1.41e-92	283.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NMZ@68525|delta/epsilon subdivisions,2WIZ0@28221|Deltaproteobacteria,2MINS@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
k59_1082918_1	1027273.GZ77_21110	2.27e-36	138.0	2DBI5@1|root,2Z9EN@2|Bacteria,1PMHG@1224|Proteobacteria,1RQE1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Exodeoxyribonuclease VIII	-	-	-	ko:K10906	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF3799
k59_85677_1	946483.Cenrod_2110	4.5e-100	301.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,4AAQZ@80864|Comamonadaceae	28216|Betaproteobacteria	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_1720939_1	420662.Mpe_A1146	1.81e-47	164.0	COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,2VH2I@28216|Betaproteobacteria,1KJIP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Belongs to the pseudomonas-type ThrB family	thrB	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
k59_1846871_1	1035308.AQYY01000001_gene2330	1.36e-89	272.0	COG0472@1|root,COG0472@2|Bacteria,1TP8W@1239|Firmicutes,247S7@186801|Clostridia,2606V@186807|Peptococcaceae	186801|Clostridia	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_379265_2	765913.ThidrDRAFT_0720	1.59e-107	316.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria,1WXBT@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
k59_966476_1	1120971.AUCA01000005_gene2238	5.23e-17	76.3	COG3666@1|root,COG3666@2|Bacteria,1VIPQ@1239|Firmicutes,4HNQW@91061|Bacilli	91061|Bacilli	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6
k59_1193582_1	927704.SELR_00600	0.000136	44.7	COG0279@1|root,COG0279@2|Bacteria,1V5W5@1239|Firmicutes,4H443@909932|Negativicutes	909932|Negativicutes	G	SIS domain	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
k59_1663528_1	1254432.SCE1572_12880	4.37e-48	173.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42VXX@68525|delta/epsilon subdivisions,2X6CT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1779516_1	367299.JOEE01000005_gene3516	1.65e-109	349.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,2GN09@201174|Actinobacteria,4FFMF@85021|Intrasporangiaceae	201174|Actinobacteria	E	glutamate synthase	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_907569_1	1123320.KB889640_gene4335	4.06e-10	65.5	2DBV7@1|root,2ZB9P@2|Bacteria,2IGRZ@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
k59_379288_1	550540.Fbal_1355	2.28e-23	105.0	COG2067@1|root,COG3637@1|root,COG2067@2|Bacteria,COG3637@2|Bacteria,1NRHE@1224|Proteobacteria,1SZT8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IM	Putative outer membrane beta-barrel porin, MtrB/PioB	-	-	-	-	-	-	-	-	-	-	-	-	MtrB_PioB
k59_1603130_1	1320556.AVBP01000015_gene887	5.94e-18	76.6	COG1942@1|root,COG1942@2|Bacteria,1NBW3@1224|Proteobacteria,2UHFK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
k59_1318740_2	472759.Nhal_3945	9.29e-42	140.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,1S25H@1236|Gammaproteobacteria,1WY0Q@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
k59_1082953_1	572477.Alvin_1618	2.41e-96	291.0	COG1363@1|root,COG1363@2|Bacteria,1MXEU@1224|Proteobacteria,1RSHP@1236|Gammaproteobacteria,1WWZP@135613|Chromatiales	135613|Chromatiales	G	peptidase M42	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
k59_1082953_2	765913.ThidrDRAFT_2547	4.8e-142	419.0	COG0189@1|root,COG0454@1|root,COG0189@2|Bacteria,COG0456@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria,1WWH7@135613|Chromatiales	135613|Chromatiales	HJ	ATP-grasp	-	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,RimK
k59_1257015_1	765910.MARPU_09580	1.56e-16	80.5	COG3378@1|root,COG4643@1|root,COG3378@2|Bacteria,COG4643@2|Bacteria,1QVIS@1224|Proteobacteria,1S02S@1236|Gammaproteobacteria,1X0DD@135613|Chromatiales	135613|Chromatiales	S	Phage plasmid primase P4 family	-	-	-	ko:K06919	-	-	-	-	ko00000	-	-	-	Toprim_3
k59_1257015_2	765910.MARPU_09575	2.85e-30	117.0	2EM8C@1|root,33EXF@2|Bacteria,1NKAT@1224|Proteobacteria,1SIRP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1257015_4	765910.MARPU_09570	6.41e-258	730.0	COG5525@1|root,COG5525@2|Bacteria,1MVS3@1224|Proteobacteria,1RRH5@1236|Gammaproteobacteria,1WZVA@135613|Chromatiales	135613|Chromatiales	S	Phage terminase large subunit (GpA)	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_GpA
k59_1491684_1	375286.mma_2658	1.04e-76	250.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,4726K@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Domain of unknown function (DUF3488)	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
k59_840862_1	1173024.KI912151_gene1639	1.73e-38	136.0	COG1309@1|root,COG1309@2|Bacteria,1G5IR@1117|Cyanobacteria,1JKA7@1189|Stigonemataceae	1117|Cyanobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1779526_1	335543.Sfum_1901	4.12e-29	117.0	COG5421@1|root,COG5421@2|Bacteria,1R7NE@1224|Proteobacteria,42M25@68525|delta/epsilon subdivisions,2WKHV@28221|Deltaproteobacteria,2MR3N@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_907583_1	671143.DAMO_1997	4e-55	186.0	COG0538@1|root,COG0538@2|Bacteria,2NS4M@2323|unclassified Bacteria	2|Bacteria	C	Isocitrate/isopropylmalate dehydrogenase	icd	GO:0003674,GO:0003824,GO:0003862,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022900,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJN746.PP_4011,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144	Iso_dh
k59_1369042_1	644548.SCNU_00495	4.35e-14	68.9	COG3093@1|root,COG3093@2|Bacteria,2IR2S@201174|Actinobacteria,4GERZ@85026|Gordoniaceae	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	higA	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
k59_1369042_2	864069.MicloDRAFT_00011820	2.19e-41	139.0	2EB38@1|root,33540@2|Bacteria,1NBMZ@1224|Proteobacteria,2UXHG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_605672_1	211165.AJLN01000153_gene663	9.58e-73	231.0	COG2230@1|root,COG2230@2|Bacteria,1G3TN@1117|Cyanobacteria,1JK00@1189|Stigonemataceae	1117|Cyanobacteria	M	Putative methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_1132072_1	1035308.AQYY01000001_gene1812	1.21e-68	222.0	COG4325@1|root,COG4325@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
k59_488485_1	593907.Celgi_0631	1.73e-72	233.0	COG1282@1|root,COG1282@2|Bacteria,2GNKB@201174|Actinobacteria,4F0EA@85016|Cellulomonadaceae	201174|Actinobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_1369046_1	314271.RB2654_18828	1.82e-117	344.0	COG1744@1|root,COG1744@2|Bacteria,1MWTM@1224|Proteobacteria,2TSZU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ABC-type transport system, periplasmic component surface lipoprotein	MA20_34830	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
k59_1663546_1	756272.Plabr_2400	8.68e-33	126.0	COG5607@1|root,COG5607@2|Bacteria	2|Bacteria	F	PFAM CHAD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
k59_1663547_1	713586.KB900536_gene289	6.18e-51	183.0	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,1RNP1@1236|Gammaproteobacteria,1WWFF@135613|Chromatiales	135613|Chromatiales	V	ABC-type transport system, involved in lipoprotein release, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_605680_1	526225.Gobs_2761	7.77e-83	268.0	COG1018@1|root,COG2124@1|root,COG1018@2|Bacteria,COG2124@2|Bacteria,2GJCV@201174|Actinobacteria,4ETZ7@85013|Frankiales	201174|Actinobacteria	C	Oxidoreductase FAD-binding	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,NAD_binding_1,p450
k59_136892_1	1121405.dsmv_1907	3.55e-28	117.0	COG1397@1|root,COG2365@1|root,COG1397@2|Bacteria,COG2365@2|Bacteria,1NTUR@1224|Proteobacteria,42NWG@68525|delta/epsilon subdivisions,2WJYQ@28221|Deltaproteobacteria,2MJ49@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ADP-ribosylglycohydrolase	-	-	3.2.2.24	ko:K05521	-	-	-	-	ko00000,ko01000	-	-	-	ADP_ribosyl_GH
k59_136892_2	1380358.JADJ01000003_gene4557	9.91e-30	118.0	COG0583@1|root,COG0583@2|Bacteria,1MWM1@1224|Proteobacteria,1RZDI@1236|Gammaproteobacteria,1XP09@135619|Oceanospirillales	135619|Oceanospirillales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1720989_1	471853.Bcav_3529	1.12e-79	249.0	COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria	201174|Actinobacteria	C	malic enzyme	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
k59_379325_1	1335757.SPICUR_02045	1.26e-112	348.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales	135613|Chromatiales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1544960_1	1121405.dsmv_3492	5.75e-122	364.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,2MI03@213118|Desulfobacterales	28221|Deltaproteobacteria	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657,ko:K13503	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_1720990_1	298386.PBPRB1708	4.66e-32	125.0	COG3385@1|root,COG3385@2|Bacteria,1R55Y@1224|Proteobacteria,1RRSD@1236|Gammaproteobacteria,1XVIP@135623|Vibrionales	135623|Vibrionales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_665141_1	765913.ThidrDRAFT_1661	1.66e-17	80.9	COG0724@1|root,COG0724@2|Bacteria,1P27V@1224|Proteobacteria,1SRKC@1236|Gammaproteobacteria,1X1B5@135613|Chromatiales	135613|Chromatiales	S	PFAM RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_488505_1	367299.JOEE01000009_gene295	1.9e-111	332.0	COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4FECW@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	corC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1082990_1	1108045.GORHZ_078_00120	5.66e-63	208.0	COG0025@1|root,COG0025@2|Bacteria,2GKCK@201174|Actinobacteria,4GAJY@85026|Gordoniaceae	201174|Actinobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1491716_1	269084.syc0190_d	2.08e-14	74.7	COG2095@1|root,COG2095@2|Bacteria,1G6CY@1117|Cyanobacteria,1H04C@1129|Synechococcus	1117|Cyanobacteria	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
k59_547041_1	655815.ZPR_4711	7.41e-35	132.0	COG2801@1|root,COG2801@2|Bacteria,4NRIR@976|Bacteroidetes,1I4VB@117743|Flavobacteriia	976|Bacteroidetes	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1846955_1	631362.Thi970DRAFT_01906	1.4e-150	438.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,1WWBR@135613|Chromatiales	135613|Chromatiales	G	PFAM glycoside hydrolase, family 77	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_30235_2	671143.DAMO_1309	2.58e-71	218.0	COG1943@1|root,COG1943@2|Bacteria,2NRRG@2323|unclassified Bacteria	2|Bacteria	L	Transposase IS200 like	isplu5A	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_1720996_1	598659.NAMH_0699	4.4e-47	166.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,42M2M@68525|delta/epsilon subdivisions,2YMS3@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
k59_966547_1	1713.JOFV01000002_gene538	4.89e-33	131.0	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4F0HT@85016|Cellulomonadaceae	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_379340_1	243233.MCA1306	7.58e-66	224.0	COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,1RP0D@1236|Gammaproteobacteria,1XE04@135618|Methylococcales	135618|Methylococcales	O	Belongs to the heat shock protein 70 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3731,HSP70
k59_1721808_1	710696.Intca_0537	8.34e-93	290.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4FFHB@85021|Intrasporangiaceae	201174|Actinobacteria	V	ABC transporter	yfiC	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_196198_1	572477.Alvin_2030	5.63e-80	245.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,1RNSW@1236|Gammaproteobacteria,1WWX4@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
k59_31519_1	768671.ThimaDRAFT_0605	8.59e-121	361.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WWEY@135613|Chromatiales	135613|Chromatiales	C	FAD linked oxidase	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1369813_1	710696.Intca_2912	8.27e-79	256.0	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria,4FEZA@85021|Intrasporangiaceae	201174|Actinobacteria	G	Alpha-amylase domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_967689_1	765913.ThidrDRAFT_3254	1.86e-76	250.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,1WWMA@135613|Chromatiales	135613|Chromatiales	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_606490_1	1049564.TevJSym_aq00490	3.02e-80	252.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1J4PN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009226,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0018130,GO:0019134,GO:0019438,GO:0030203,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0042546,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046872,GO:0055086,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903509	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iECED1_1282.ECED1_4420,iYL1228.KPN_04135	Hexapep,Hexapep_2,NTP_transf_3
k59_606490_2	1182590.BN5_04416	5.16e-19	86.3	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1YDG9@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009987,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iE2348C_1286.E2348C_4039,iEC042_1314.EC042_4115,iECIAI39_1322.ECIAI39_4333,iECNA114_1301.ECNA114_3878,iECOK1_1307.ECOK1_4178,iECSF_1327.ECSF_3577,iECUMN_1333.ECUMN_4259,iEcSMS35_1347.EcSMS35_4097,iLF82_1304.LF82_0844,iNRG857_1313.NRG857_18570,iSFV_1184.SFV_3755,iSF_1195.SF3809,iSFxv_1172.SFxv_4151,iS_1188.S3959,iUMN146_1321.UM146_18835,iUTI89_1310.UTI89_C4281	GATase_6,SIS
k59_313365_1	396588.Tgr7_2406	8.95e-66	219.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1WX4H@135613|Chromatiales	135613|Chromatiales	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	OapA,Peptidase_M23
k59_430477_1	717772.THIAE_09345	1.6e-37	144.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,4622X@72273|Thiotrichales	72273|Thiotrichales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_489296_1	1297570.MESS4_p50001	3.16e-71	223.0	COG0730@1|root,COG0730@2|Bacteria,1MVA4@1224|Proteobacteria,2U2D5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	TauE
k59_380484_2	1221522.B723_14700	8.01e-42	153.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RMDA@1236|Gammaproteobacteria,1YSWX@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	MU	Outer membrane efflux protein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
k59_1721832_1	2340.JV46_19050	6.7e-49	175.0	COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,1T214@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3306,Fer4,Fer4_10,Fer4_6,Fer4_7
k59_1664386_1	1120970.AUBZ01000002_gene842	6.07e-14	75.9	29JMV@1|root,306J6@2|Bacteria,1RDSQ@1224|Proteobacteria,1S492@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2860)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2860
k59_430484_1	1255043.TVNIR_3306	1.72e-23	91.3	COG2026@1|root,COG2026@2|Bacteria,1N76D@1224|Proteobacteria,1SCNM@1236|Gammaproteobacteria,1WZG1@135613|Chromatiales	135613|Chromatiales	DJ	TIGRFAM Addiction module toxin, RelE StbE	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
k59_430484_2	1163617.SCD_n01303	3.85e-45	147.0	COG3668@1|root,COG3668@2|Bacteria,1N016@1224|Proteobacteria,2VVYK@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Plasmid stabilization system	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
k59_137643_1	794903.OPIT5_11255	8.87e-110	335.0	COG0012@1|root,COG0012@2|Bacteria,46UY8@74201|Verrucomicrobia	74201|Verrucomicrobia	J	GTP binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_606510_1	1392540.P256_02179	2.05e-22	97.4	COG0111@1|root,COG0111@2|Bacteria,1N5TD@1224|Proteobacteria,1RMFW@1236|Gammaproteobacteria,3NKB6@468|Moraxellaceae	1236|Gammaproteobacteria	H	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate	pdxB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0033711,GO:0034641,GO:0036001,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.1.1.290	ko:K03473	ko00750,ko01100,map00750,map01100	M00124	R04210	RC00084	ko00000,ko00001,ko00002,ko01000	-	-	iZ_1308.Z3582	2-Hacid_dh,2-Hacid_dh_C,DUF3410
k59_606510_2	2340.JV46_07080	8.6e-41	147.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1J4ZC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_665889_1	765913.ThidrDRAFT_0898	6.62e-31	118.0	COG2143@1|root,COG2143@2|Bacteria,1QDKY@1224|Proteobacteria,1RZ7R@1236|Gammaproteobacteria,1WX5T@135613|Chromatiales	135613|Chromatiales	O	Thioredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
k59_665889_2	395493.BegalDRAFT_3110	3.43e-76	235.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,460UW@72273|Thiotrichales	72273|Thiotrichales	IQ	short-chain dehydrogenase reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_39027_1	180332.JTGN01000023_gene1623	3.64e-60	212.0	COG3507@1|root,COG3533@1|root,COG5492@1|root,COG3507@2|Bacteria,COG3533@2|Bacteria,COG5492@2|Bacteria,1TW7Y@1239|Firmicutes,24AP8@186801|Clostridia	186801|Clostridia	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_916754_1	765911.Thivi_2291	6.22e-26	108.0	COG3515@1|root,COG3515@2|Bacteria,1NK35@1224|Proteobacteria,1RQHZ@1236|Gammaproteobacteria,1WYRE@135613|Chromatiales	135613|Chromatiales	S	ImpA, N-terminal, type VI secretion system	-	-	-	ko:K11902	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	ImpA_N
k59_1328044_1	1219035.NT2_01_01250	5.52e-08	59.3	COG3746@1|root,COG3746@2|Bacteria,1RA39@1224|Proteobacteria,2U0ZX@28211|Alphaproteobacteria,2K1KI@204457|Sphingomonadales	204457|Sphingomonadales	P	phosphate-selective porin	-	-	-	ko:K07221	-	-	-	-	ko00000,ko02000	1.B.5.1	-	-	Porin_O_P
k59_975841_1	1317118.ATO8_02755	4.62e-07	56.6	COG1657@1|root,COG1657@2|Bacteria,1NACB@1224|Proteobacteria,2UWYN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1089566_2	472759.Nhal_3004	2.36e-29	116.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,1RP3U@1236|Gammaproteobacteria,1WZUN@135613|Chromatiales	135613|Chromatiales	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
k59_670366_1	1123242.JH636437_gene6091	5.15e-171	503.0	COG0433@1|root,COG0433@2|Bacteria,2IY71@203682|Planctomycetes	203682|Planctomycetes	L	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87,PDDEXK_1
k59_200689_1	713586.KB900536_gene1304	6.29e-08	55.8	COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria	1224|Proteobacteria	T	PFAM Forkhead-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
k59_1199169_1	1499967.BAYZ01000027_gene1810	2.89e-09	64.7	COG2203@1|root,COG3920@1|root,COG2203@2|Bacteria,COG3920@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
k59_318150_1	1144342.PMI40_00361	1.2e-06	50.1	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,2VHI1@28216|Betaproteobacteria,472SF@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_318150_2	795666.MW7_2669	9.68e-28	110.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,2VI7V@28216|Betaproteobacteria,1JZY7@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
k59_916770_2	414684.RC1_1475	1.28e-38	133.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2U75U@28211|Alphaproteobacteria,2JT3D@204441|Rhodospirillales	204441|Rhodospirillales	Q	COG4665 TRAP-type mannitol chloroaromatic compound transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_493912_1	1268622.AVS7_01705	4.94e-52	169.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2VR4X@28216|Betaproteobacteria,4ADXJ@80864|Comamonadaceae	28216|Betaproteobacteria	I	Cyclase dehydrase	ratA	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
k59_493912_2	715451.ambt_07035	8.11e-28	105.0	COG2914@1|root,COG2914@2|Bacteria,1MZCH@1224|Proteobacteria,1SCHG@1236|Gammaproteobacteria,467WA@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Belongs to the UPF0125 (RnfH) family	rnfH	-	-	ko:K09801	-	-	-	-	ko00000	-	-	-	Ub-RnfH
k59_388510_1	1267005.KB911255_gene2625	2.02e-69	225.0	COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2TT1X@28211|Alphaproteobacteria,3N7WM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Domain of unknown function (DUF3390)	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_17,Fer4_8,LUD_dom
k59_95004_1	349124.Hhal_1072	1.37e-118	347.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,1RMR5@1236|Gammaproteobacteria,1WWC7@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	prpB	-	4.1.3.30	ko:K03417	ko00640,map00640	-	R00409	RC00286,RC00287	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
k59_1550032_1	1349820.M707_07825	6.16e-146	437.0	COG5617@1|root,COG5617@2|Bacteria,2HKW0@201174|Actinobacteria,1W929@1268|Micrococcaceae	201174|Actinobacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_917668_2	1076550.LH22_18535	4.26e-18	88.2	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,3VZFS@53335|Pantoea	1236|Gammaproteobacteria	M	Belongs to the peptidase S1C family	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016020,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	1.3.1.74,3.4.21.107	ko:K04771,ko:K04772,ko:K08070	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
k59_1857251_1	187272.Mlg_1344	2.05e-126	379.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1WW67@135613|Chromatiales	135613|Chromatiales	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_729375_1	1137799.GZ78_00175	9.38e-65	213.0	COG4783@1|root,COG4783@2|Bacteria,1RAJB@1224|Proteobacteria,1SA1F@1236|Gammaproteobacteria,1XPS8@135619|Oceanospirillales	135619|Oceanospirillales	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_553035_2	459349.CLOAM1527	2.17e-29	119.0	COG4658@1|root,COG4658@2|Bacteria,2NP3H@2323|unclassified Bacteria	2|Bacteria	U	Part of a membrane complex involved in electron transport	rnfD	-	1.6.5.8	ko:K00347,ko:K03614	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
k59_846864_1	765913.ThidrDRAFT_3401	4.96e-121	352.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,1RNPS@1236|Gammaproteobacteria,1WW1D@135613|Chromatiales	135613|Chromatiales	M	PFAM VacJ family lipoprotein	-	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
k59_389384_1	1121405.dsmv_1005	3.84e-110	337.0	COG2766@1|root,COG2766@2|Bacteria,1PXNG@1224|Proteobacteria,42N5G@68525|delta/epsilon subdivisions,2WINM@28221|Deltaproteobacteria,2MINW@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Serine protein kinase	prkA	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
k59_1498587_1	243231.GSU1269	7.06e-65	227.0	COG1470@1|root,COG5276@1|root,COG1470@2|Bacteria,COG5276@2|Bacteria,1NTT8@1224|Proteobacteria,42ZD4@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
k59_729381_1	1267005.KB911257_gene1077	5.96e-74	250.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,3N63N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Alpha-2-Macroglobulin	MA20_30110	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,PAN_1,Thiol-ester_cl
k59_917697_1	485915.Dret_1963	4.91e-45	157.0	COG1150@1|root,COG2181@1|root,COG1150@2|Bacteria,COG2181@2|Bacteria,1QUKA@1224|Proteobacteria,42MNE@68525|delta/epsilon subdivisions,2WIN3@28221|Deltaproteobacteria,2M85U@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	qmoC	-	-	ko:K16887	-	-	-	-	ko00000	-	-	-	Fer4_17,Fer4_8,Fer4_9,Nitrate_red_gam
k59_917697_2	335543.Sfum_1286	2.97e-131	394.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,42NNE@68525|delta/epsilon subdivisions,2WJZX@28221|Deltaproteobacteria,2MRB1@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	qmoB	-	-	ko:K16886	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_9,FlpD,Pyr_redox_2
k59_1090073_1	795359.TOPB45_1303	1.64e-13	73.9	COG0046@1|root,COG1828@1|root,COG0046@2|Bacteria,COG1828@2|Bacteria,2GH61@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,PurS
k59_553045_1	1028800.RG540_CH13770	1.64e-36	135.0	COG0258@1|root,COG0258@2|Bacteria,1MYSI@1224|Proteobacteria,2U60N@28211|Alphaproteobacteria,4BJMF@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	5'-3' exonuclease, N-terminal resolvase-like domain	-	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc_N
k59_846873_1	247639.MGP2080_05887	2.28e-68	235.0	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RZ2T@1236|Gammaproteobacteria,1JBTX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Hexapep_2,PP-binding
k59_1669607_1	1123371.ATXH01000013_gene1510	2.72e-94	300.0	COG0550@1|root,COG0550@2|Bacteria,2GH60@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	Bacterial DNA topoisomeraes I ATP-binding domain	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
k59_1784825_2	765912.Thimo_1967	4.96e-54	181.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,1WVX4@135613|Chromatiales	135613|Chromatiales	I	TIGRFAM acetyl-CoA carboxylase, biotin carboxylase	-	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_553050_1	1150600.ADIARSV_1362	3.72e-12	71.6	COG3291@1|root,COG3291@2|Bacteria,4NHAX@976|Bacteroidetes,1IRW7@117747|Sphingobacteriia	976|Bacteroidetes	S	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9
k59_729398_1	319224.Sputcn32_2772	4.33e-53	173.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,2QBS7@267890|Shewanellaceae	1236|Gammaproteobacteria	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	pgpA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	iECSP_1301.ECSP_0485,iECUMN_1333.ECUMN_0456,iECs_1301.ECs0471,iG2583_1286.G2583_0529,iPC815.YPO3179,iZ_1308.Z0520	PgpA
k59_846875_1	926560.KE387023_gene3658	1.54e-38	137.0	COG0500@1|root,COG2226@2|Bacteria,1WMEJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_846875_2	479431.Namu_0372	5.64e-78	235.0	COG0748@1|root,COG0748@2|Bacteria,2IP6Y@201174|Actinobacteria	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
k59_846875_3	1297865.APJD01000004_gene5296	1.45e-23	104.0	COG1680@1|root,COG1680@2|Bacteria,1NHIY@1224|Proteobacteria,2U0A3@28211|Alphaproteobacteria,3JT7A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_670876_1	888056.HMPREF9062_1292	3.02e-14	73.6	COG0228@1|root,COG0228@2|Bacteria,2IKU0@201174|Actinobacteria,4D5N7@85005|Actinomycetales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
k59_670876_2	411464.DESPIG_01572	1.19e-15	70.9	COG1837@1|root,COG1837@2|Bacteria,1N7IX@1224|Proteobacteria,42TXI@68525|delta/epsilon subdivisions,2WQBS@28221|Deltaproteobacteria,2MCGN@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Belongs to the UPF0109 family	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
k59_1374645_1	1121405.dsmv_0778	1.25e-55	189.0	COG0477@1|root,COG0477@2|Bacteria,1MWUR@1224|Proteobacteria,43BPW@68525|delta/epsilon subdivisions,2X714@28221|Deltaproteobacteria,2MI7Z@213118|Desulfobacterales	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_611745_1	1144275.COCOR_05728	2.63e-83	282.0	COG4630@1|root,COG4631@1|root,COG4630@2|Bacteria,COG4631@2|Bacteria,1NQSR@1224|Proteobacteria,43C3C@68525|delta/epsilon subdivisions,2X7DZ@28221|Deltaproteobacteria,2YWS9@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	xdhB	-	1.17.1.4	ko:K13482	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
k59_784223_1	665571.STHERM_c21570	7.35e-115	347.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,2J5JF@203691|Spirochaetes	203691|Spirochaetes	C	Oxaloacetate decarboxylase, alpha subunit	oadA	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_1727102_1	1247963.JPHU01000021_gene17	2.05e-33	131.0	COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,2TTGG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cusB	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	CusF_Ec,HlyD_D23,HlyD_D4
k59_670885_1	56780.SYN_01156	1.51e-75	249.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2MQ92@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K01338,ko:K04076,ko:K04770	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Lon_C
k59_611756_1	380358.XALC_3137	8.84e-152	442.0	COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,1S1TG@1236|Gammaproteobacteria,1X9XT@135614|Xanthomonadales	135614|Xanthomonadales	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_318703_1	1116472.MGMO_6c00070	1.09e-78	249.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1XEW1@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_318703_2	870187.Thini_0887	0.000272	42.7	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,460BG@72273|Thiotrichales	72273|Thiotrichales	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	cyoA	-	1.10.3.10,1.9.3.1	ko:K02275,ko:K02297	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081,R11335	RC00016,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX2,COX2_TM,COX_ARM
k59_1727118_1	1380393.JHVP01000002_gene1501	7.31e-51	174.0	COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4ERJ6@85013|Frankiales	201174|Actinobacteria	M	Belongs to the EPSP synthase family. MurA subfamily	murA	GO:0008150,GO:0040007	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_1727118_2	1003195.SCAT_4201	4.31e-08	52.4	COG2096@1|root,COG2096@2|Bacteria,2GMHN@201174|Actinobacteria	201174|Actinobacteria	S	adenosyltransferase	yvqK	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
k59_553078_1	1123065.ATWL01000001_gene413	2.33e-111	326.0	COG0149@1|root,COG0149@2|Bacteria,2GJXZ@201174|Actinobacteria	201174|Actinobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
k59_917770_1	411684.HPDFL43_21579	2.62e-47	160.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TU63@28211|Alphaproteobacteria,43RD9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k59_95997_1	745411.B3C1_04635	2.09e-88	285.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1J98P@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Domain of unknown function (DUF1974)	fadE	GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	iSbBS512_1146.SbBS512_E0217	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_1857358_1	335543.Sfum_1044	1.99e-66	222.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria,2MR0P@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA-2	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_494447_1	1149133.ppKF707_5614	6.3e-76	248.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1YF1J@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_1727127_1	204669.Acid345_1682	1.96e-26	114.0	COG0457@1|root,COG0457@2|Bacteria,3Y2IK@57723|Acidobacteria,2JKNM@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8,UnbV_ASPIC,VCBS
k59_389481_1	2340.JV46_08190	1.79e-21	91.7	COG2242@1|root,COG2242@2|Bacteria,1R79F@1224|Proteobacteria,1RY3Z@1236|Gammaproteobacteria,1J8AJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_389481_2	1249627.D779_4003	2.04e-20	99.0	2DS07@1|root,33DXS@2|Bacteria,1QWHF@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_389481_3	156889.Mmc1_0518	3.84e-107	325.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TS80@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_435688_1	216596.RL1127	3.35e-33	134.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,TPR_16,TPR_19,TPR_2,TPR_8
k59_1498632_1	1232410.KI421421_gene3769	4.87e-49	171.0	COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,42NTH@68525|delta/epsilon subdivisions,2WJ8N@28221|Deltaproteobacteria,43S96@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
k59_1374680_1	886293.Sinac_1185	1.88e-34	123.0	COG0378@1|root,COG0378@2|Bacteria,2J22S@203682|Planctomycetes	203682|Planctomycetes	KO	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	ko:K03189	-	-	-	-	ko00000	-	-	-	cobW
k59_1374680_2	1136138.JH604622_gene2208	1.24e-22	96.3	COG0829@1|root,COG0829@2|Bacteria,1NY7J@1224|Proteobacteria,1RY0U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureD	-	-	ko:K03190	-	-	-	-	ko00000	-	-	-	UreD
k59_784250_1	1386089.N865_03210	4.08e-135	402.0	COG3039@1|root,COG3547@1|root,COG3039@2|Bacteria,COG3547@2|Bacteria,2HW75@201174|Actinobacteria	201174|Actinobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_611779_1	1048983.EL17_09835	5.83e-07	53.5	COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,47JBS@768503|Cytophagia	976|Bacteroidetes	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
k59_976880_1	1121405.dsmv_2870	1.7e-74	241.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2WJPF@28221|Deltaproteobacteria,2MHXP@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_917798_2	1121106.JQKB01000116_gene5362	5.82e-14	72.0	COG1961@1|root,COG3039@1|root,COG1961@2|Bacteria,COG3039@2|Bacteria,1MXTN@1224|Proteobacteria,2TYT4@28211|Alphaproteobacteria,2JWYX@204441|Rhodospirillales	204441|Rhodospirillales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_5
k59_1329107_1	1249627.D779_1371	1.23e-181	520.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales	135613|Chromatiales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_1608727_1	1410676.JNKL01000008_gene57	0.000622	46.2	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1Y430@135624|Aeromonadales	135624|Aeromonadales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_96032_1	1121405.dsmv_3385	1.56e-49	166.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,42MI2@68525|delta/epsilon subdivisions,2WJ5W@28221|Deltaproteobacteria,2MIJR@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2848	Pribosyl_synth,Pribosyltran_N
k59_1374687_1	1304865.JAGF01000001_gene2689	9.76e-70	222.0	COG5002@1|root,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4F13N@85016|Cellulomonadaceae	201174|Actinobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_1498644_2	1267005.KB911255_gene2538	3.96e-17	83.2	COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,2TRP0@28211|Alphaproteobacteria,3N88X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Lytic murein transglycosylase	MA20_44755	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	PG_binding_1,SLT_2
k59_1857400_1	743719.PaelaDRAFT_3582	2.84e-81	264.0	COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,4HAZK@91061|Bacilli,26RQ2@186822|Paenibacillaceae	91061|Bacilli	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_729459_1	631362.Thi970DRAFT_01415	5.45e-72	228.0	COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,1S44I@1236|Gammaproteobacteria,1WYJP@135613|Chromatiales	135613|Chromatiales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1374693_2	1265502.KB905949_gene952	2.62e-40	144.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2VHTW@28216|Betaproteobacteria,4AAJM@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	TIGRFAM Drug resistance transporter Bcr CflA subfamily	bcr	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_1329133_1	987059.RBXJA2T_15588	5.1e-32	133.0	COG0642@1|root,COG0834@1|root,COG2461@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG2205@2|Bacteria,COG2461@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,1KJCZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	4HB_MCP_1,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg,SBP_bac_3
k59_1857417_1	572477.Alvin_1520	1.05e-41	142.0	COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,1S3QT@1236|Gammaproteobacteria,1WXYR@135613|Chromatiales	135613|Chromatiales	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
k59_435714_1	1122135.KB893135_gene637	2.27e-54	189.0	COG2966@1|root,COG3610@1|root,COG2966@2|Bacteria,COG3610@2|Bacteria,1NH2X@1224|Proteobacteria,2U69Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative threonine/serine exporter	-	-	-	-	-	-	-	-	-	-	-	-	ThrE,ThrE_2
k59_784267_1	391735.Veis_0365	1.69e-34	128.0	COG0406@1|root,COG0406@2|Bacteria,1RB0S@1224|Proteobacteria,2VJR8@28216|Betaproteobacteria,4AABW@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM Phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_494483_1	585531.HMPREF0063_11756	3.21e-47	165.0	COG0372@1|root,COG0372@2|Bacteria,2GKST@201174|Actinobacteria,4DP3K@85009|Propionibacteriales	201174|Actinobacteria	C	Belongs to the citrate synthase family	citA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_1095775_1	1122933.JNIY01000011_gene1208	2.19e-58	202.0	COG3119@1|root,COG3119@2|Bacteria,2H59R@201174|Actinobacteria,4F222@85016|Cellulomonadaceae	201174|Actinobacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1095775_2	471853.Bcav_0375	3.25e-128	376.0	COG1215@1|root,COG1215@2|Bacteria,2GMKV@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_985844_1	908612.HMPREF9720_2461	1.46e-31	122.0	COG0205@1|root,COG0205@2|Bacteria,4NF8F@976|Bacteroidetes,2FMPI@200643|Bacteroidia,22UGZ@171550|Rikenellaceae	976|Bacteroidetes	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
k59_104774_1	880073.Calab_3567	8.88e-60	202.0	COG3666@1|root,COG3666@2|Bacteria,2NPCA@2323|unclassified Bacteria	2|Bacteria	L	COGs COG3666 Transposase and inactivated derivatives	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1095779_1	655812.HMPREF0061_1689	2.82e-63	204.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli,27DIH@186827|Aerococcaceae	91061|Bacilli	D	Phage integrase, N-terminal SAM-like domain	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1866295_1	469383.Cwoe_1820	5.2e-148	434.0	COG2072@1|root,COG2072@2|Bacteria,2GMDH@201174|Actinobacteria,4CS42@84995|Rubrobacteria	84995|Rubrobacteria	P	Flavin-binding monooxygenase-like	-	-	-	-	-	-	-	-	-	-	-	-	FMO-like
k59_206661_1	1121405.dsmv_3691	9.71e-59	192.0	COG3547@1|root,COG3547@2|Bacteria,1NP2U@1224|Proteobacteria,43A5Q@68525|delta/epsilon subdivisions,2X2AM@28221|Deltaproteobacteria,2MPDW@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_926723_1	525903.Taci_1260	1.04e-25	110.0	COG0733@1|root,COG0733@2|Bacteria,3T9W5@508458|Synergistetes	508458|Synergistetes	P	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_499716_1	395961.Cyan7425_3233	9.83e-40	149.0	COG0659@1|root,COG0659@2|Bacteria,1G0NU@1117|Cyanobacteria,3KH90@43988|Cyanothece	1117|Cyanobacteria	P	Sulfate transporter antisigma-factor antagonist STAS	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1141985_1	869213.JCM21142_41533	9.98e-116	357.0	COG3808@1|root,COG3808@2|Bacteria,4NF2I@976|Bacteroidetes,47MRY@768503|Cytophagia	976|Bacteroidetes	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase,OmpA
k59_1789296_1	639283.Snov_0742	4.6e-54	194.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2TRUM@28211|Alphaproteobacteria,3EYZF@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Domain of unknown function (DUF3458_C) ARM repeats	pepN	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
k59_206670_2	290397.Adeh_4122	6.35e-51	185.0	COG0784@1|root,COG0840@1|root,COG1511@1|root,COG4251@1|root,COG0784@2|Bacteria,COG0840@2|Bacteria,COG1511@2|Bacteria,COG4251@2|Bacteria,1NC9X@1224|Proteobacteria,43BZ2@68525|delta/epsilon subdivisions,2X79T@28221|Deltaproteobacteria,2YU1H@29|Myxococcales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,Response_reg
k59_852054_2	870187.Thini_4182	5.38e-56	185.0	COG0446@1|root,COG0446@2|Bacteria,1QA17@1224|Proteobacteria,1RSA6@1236|Gammaproteobacteria,45ZTC@72273|Thiotrichales	72273|Thiotrichales	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1614010_2	1274.HX89_00160	7.21e-08	57.8	COG3335@1|root,COG3335@2|Bacteria,2GJQI@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_29,HTH_32
k59_788544_1	522772.Dacet_1168	2.02e-40	154.0	COG0784@1|root,COG2198@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_1789306_1	179408.Osc7112_1728	3.31e-09	53.9	COG1872@1|root,COG1872@2|Bacteria,1G935@1117|Cyanobacteria,1HD36@1150|Oscillatoriales	1117|Cyanobacteria	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
k59_1789306_2	425104.Ssed_1657	5.08e-73	223.0	2DJ8V@1|root,3050U@2|Bacteria,1RE7U@1224|Proteobacteria,1SNMT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	-
k59_441041_1	1121405.dsmv_2303	7.89e-99	291.0	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,42SPM@68525|delta/epsilon subdivisions,2WMYY@28221|Deltaproteobacteria,2MK4C@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Haemolysin-III related	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
k59_1732316_1	367299.JOEE01000006_gene773	2.02e-35	138.0	COG0151@1|root,COG0151@2|Bacteria,2I62N@201174|Actinobacteria,4FE38@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the GarS family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_499733_1	765913.ThidrDRAFT_2816	6.9e-65	220.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1WXQF@135613|Chromatiales	135613|Chromatiales	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_499733_2	156889.Mmc1_0519	5.68e-09	58.5	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TS80@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1338085_1	471852.Tcur_3248	1.1e-18	80.1	COG0537@1|root,COG0537@2|Bacteria,2IHPT@201174|Actinobacteria,4EJSG@85012|Streptosporangiales	201174|Actinobacteria	FG	HIT domain	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	DcpS_C,HIT
k59_1440027_1	1535422.ND16A_0646	2.17e-32	129.0	COG0758@1|root,COG0758@2|Bacteria,1N2UI@1224|Proteobacteria	1224|Proteobacteria	LU	DNA mediated transformation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1095821_1	1172181.KB911701_gene858	9.36e-11	62.4	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_1095821_2	351607.Acel_0953	3.83e-43	146.0	arCOG04740@1|root,31PZA@2|Bacteria,2GP15@201174|Actinobacteria,4EVI8@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_499741_1	686340.Metal_1163	4.11e-117	355.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1XE08@135618|Methylococcales	135618|Methylococcales	C	NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding	-	-	1.12.1.2	ko:K18005	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S
k59_1338099_1	1121937.AUHJ01000005_gene2218	1.88e-28	118.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,4649V@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_1674969_1	1397666.RS24_00311	6.15e-71	224.0	COG0803@1|root,COG0803@2|Bacteria,1R91T@1224|Proteobacteria,2TRDQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
k59_1732334_1	316058.RPB_3306	1.56e-06	55.8	COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,2U05W@28211|Alphaproteobacteria,3JV47@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_integrase
k59_1504553_1	1396141.BATP01000007_gene5771	5.32e-29	118.0	COG1502@1|root,COG1502@2|Bacteria,46U9X@74201|Verrucomicrobia,2ITQD@203494|Verrucomicrobiae	2|Bacteria	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_398388_1	335543.Sfum_1991	1.32e-75	244.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MQU1@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
k59_1866385_1	670307.HYPDE_41603	4.77e-155	458.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2TRH3@28211|Alphaproteobacteria,3N6CB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_558300_1	452637.Oter_2603	5.11e-39	148.0	COG2864@1|root,COG2864@2|Bacteria	2|Bacteria	C	formate dehydrogenase	cbcY	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C7,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese
k59_616951_1	1198232.CYCME_0386	8.93e-150	440.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNNJ@1236|Gammaproteobacteria,4607G@72273|Thiotrichales	72273|Thiotrichales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1504572_1	1292034.OR37_02974	2.28e-24	94.7	COG3609@1|root,COG3609@2|Bacteria,1N9NJ@1224|Proteobacteria,2UG3J@28211|Alphaproteobacteria,2KHHY@204458|Caulobacterales	204458|Caulobacterales	K	addiction module antidote protein, CC2985 family	-	GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0046983,GO:0051259,GO:0051262,GO:0051290,GO:0051291,GO:0065003,GO:0071840	-	ko:K07746	-	-	-	-	ko00000,ko02048	-	-	-	ParD_antitoxin
k59_926826_1	439235.Dalk_2884	2.61e-54	175.0	COG1051@1|root,COG1051@2|Bacteria,1MZHT@1224|Proteobacteria,42S22@68525|delta/epsilon subdivisions,2WNBV@28221|Deltaproteobacteria,2MK8Y@213118|Desulfobacterales	28221|Deltaproteobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N_2
k59_616954_1	1101190.ARWB01000001_gene2656	9.55e-20	89.0	COG2266@1|root,COG2266@2|Bacteria,1RFQ8@1224|Proteobacteria,2U7WE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	MobA-like NTP transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
k59_206728_1	595460.RRSWK_03108	1.98e-40	150.0	COG1520@1|root,COG1520@2|Bacteria,2IWR8@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
k59_1555869_1	377629.TERTU_4644	2.54e-18	82.4	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,2PMYX@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	D	Ferrous iron transport protein B	engB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
k59_47033_1	593907.Celgi_0935	4.36e-22	89.4	COG1872@1|root,COG1872@2|Bacteria,2GQSC@201174|Actinobacteria	201174|Actinobacteria	EGP	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
k59_47033_2	223283.PSPTO_1361	2.03e-35	136.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RR5Z@1236|Gammaproteobacteria,1Z9AJ@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	J	Amidase	atzF	-	3.5.1.54	ko:K01457	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120	-	R00005	RC02756	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_148148_1	550540.Fbal_0130	1.83e-09	55.8	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019103,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0051259,GO:0051260,GO:0055086,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
k59_148148_2	511062.GU3_03150	1.11e-24	104.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1Y3V3@135624|Aeromonadales	135624|Aeromonadales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k59_47041_1	743718.Isova_0826	8.23e-76	259.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GJD0@201174|Actinobacteria,4F3NY@85017|Promicromonosporaceae	201174|Actinobacteria	L	UvrD/REP helicase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,PDDEXK_1,UvrD-helicase,UvrD_C
k59_1732996_2	765911.Thivi_3828	3.23e-48	160.0	COG2891@1|root,COG2891@2|Bacteria,1RER7@1224|Proteobacteria,1S8VI@1236|Gammaproteobacteria,1WYH2@135613|Chromatiales	135613|Chromatiales	M	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins	-	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
k59_1732996_3	1121004.ATVC01000031_gene1518	5.43e-24	103.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,2KPKN@206351|Neisseriales	206351|Neisseriales	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_1096644_1	1144275.COCOR_06541	4.02e-112	330.0	COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,42P6R@68525|delta/epsilon subdivisions,2WKXS@28221|Deltaproteobacteria,2YUES@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the peptidase S33 family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
k59_281028_1	706587.Desti_1337	2.33e-41	155.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MQ8R@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
k59_500448_1	1430440.MGMSRv2_1763	8.65e-100	301.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2TRKB@28211|Alphaproteobacteria,2JPD3@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
k59_106001_1	1304275.C41B8_00145	4.33e-38	139.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1380726_1	479431.Namu_4080	6.94e-72	239.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4ERQZ@85013|Frankiales	201174|Actinobacteria	G	pyruvate phosphate dikinase, PEP	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_441777_1	471853.Bcav_2061	8.68e-97	291.0	COG0805@1|root,COG0805@2|Bacteria,2GJK8@201174|Actinobacteria	201174|Actinobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_1205624_1	1267005.KB911259_gene3866	9.88e-72	228.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2TQWH@28211|Alphaproteobacteria,3N67C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1271048_1	471853.Bcav_0228	1.99e-167	511.0	COG1643@1|root,COG3170@1|root,COG1643@2|Bacteria,COG3170@2|Bacteria,2GIWX@201174|Actinobacteria	201174|Actinobacteria	L	ATP-dependent helicase	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_1440747_1	713586.KB900536_gene2406	2.79e-18	82.8	COG3087@1|root,COG3087@2|Bacteria,1RCC0@1224|Proteobacteria,1SBGX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
k59_324640_1	247639.MGP2080_05977	2.33e-94	304.0	COG1629@1|root,COG1629@2|Bacteria,1MV8W@1224|Proteobacteria,1RQEQ@1236|Gammaproteobacteria,1J4HT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_735783_1	794903.OPIT5_26155	4.66e-72	238.0	COG0318@1|root,COG0318@2|Bacteria,46SG3@74201|Verrucomicrobia,3K8JV@414999|Opitutae	414999|Opitutae	IQ	Phosphate acyltransferases	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C,Acyltransferase
k59_1733002_1	580332.Slit_1119	1.46e-25	107.0	COG3278@1|root,COG3278@2|Bacteria,1P8T0@1224|Proteobacteria,2VNAW@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the heme-copper respiratory oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1733002_3	28229.ND2E_0218	6.56e-42	143.0	COG3945@1|root,COG3945@2|Bacteria,1N383@1224|Proteobacteria,1S89I@1236|Gammaproteobacteria,2Q85A@267889|Colwelliaceae	1236|Gammaproteobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
k59_1733002_4	572477.Alvin_1393	9.61e-37	130.0	COG3154@1|root,COG3154@2|Bacteria,1RB7T@1224|Proteobacteria,1RMJD@1236|Gammaproteobacteria,1WY2A@135613|Chromatiales	135613|Chromatiales	I	Sterol-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
k59_1733002_5	1283300.ATXB01000002_gene2631	4.38e-66	208.0	COG1814@1|root,COG1814@2|Bacteria,1RBQN@1224|Proteobacteria,1S2ZU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1733002_6	177439.DP2436	1.98e-24	94.7	COG1888@1|root,COG1888@2|Bacteria,1N92Y@1224|Proteobacteria	1224|Proteobacteria	S	Uncharacterized ArCR, COG1888	-	-	-	ko:K09732	-	-	-	-	ko00000	-	-	-	DUF211
k59_441787_1	1342301.JASD01000008_gene2483	8.38e-18	81.6	COG3788@1|root,COG3788@2|Bacteria,1RDHP@1224|Proteobacteria,2UDRD@28211|Alphaproteobacteria,3ZXT8@60136|Sulfitobacter	28211|Alphaproteobacteria	S	MAPEG family	-	-	-	ko:K07136	-	-	-	-	ko00000	-	-	-	MAPEG
k59_441787_2	1122970.AUHC01000013_gene1074	2.28e-60	189.0	COG3565@1|root,COG3565@2|Bacteria,1RD7C@1224|Proteobacteria,2U78G@28211|Alphaproteobacteria,2K4FM@204457|Sphingomonadales	204457|Sphingomonadales	S	dioxygenase of extradiol dioxygenase family	-	-	-	ko:K06991	-	-	-	-	ko00000	-	-	-	Glyoxalase
k59_441787_3	1123392.AQWL01000005_gene3207	4.03e-52	173.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2VIN4@28216|Betaproteobacteria,1KS77@119069|Hydrogenophilales	119069|Hydrogenophilales	H	Coproporphyrinogen III oxidase	-	-	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
k59_677169_1	663610.JQKO01000001_gene865	2.57e-150	456.0	COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,2TW58@28211|Alphaproteobacteria,3NAP2@45404|Beijerinckiaceae	28211|Alphaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K13926	-	-	-	-	ko00000	-	-	-	ABC2_membrane_3,ABC_tran
k59_500469_1	335543.Sfum_1173	2.53e-74	248.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_6,Pyr_redox_2
k59_207414_2	479432.Sros_8856	1.51e-63	195.0	COG1695@1|root,COG1695@2|Bacteria,2IM8U@201174|Actinobacteria,4EPD2@85012|Streptosporangiales	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
k59_207414_3	1278078.G419_02275	5.04e-64	197.0	COG4817@1|root,COG4817@2|Bacteria,2IMFK@201174|Actinobacteria,4G98S@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1048)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1048
k59_324646_1	335543.Sfum_0184	1.46e-68	219.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,42NUT@68525|delta/epsilon subdivisions,2WKQX@28221|Deltaproteobacteria,2MRX6@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_789186_1	317619.ANKN01000126_gene3251	7.53e-17	87.0	COG1216@1|root,COG1216@2|Bacteria,1G48C@1117|Cyanobacteria	1117|Cyanobacteria	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1867546_1	562973.HMPREF0059_01700	3.07e-55	177.0	COG0231@1|root,COG0231@2|Bacteria,2GJMS@201174|Actinobacteria,4D340@85005|Actinomycetales	201174|Actinobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
k59_1675722_1	762984.HMPREF9445_00693	3.35e-12	72.4	COG0457@1|root,COG0457@2|Bacteria,4NERG@976|Bacteroidetes,2FMK5@200643|Bacteroidia,4AK7T@815|Bacteroidaceae	976|Bacteroidetes	S	COG NOG06393 non supervised orthologous group	batD	-	-	-	-	-	-	-	-	-	-	-	BatD,TPR_2
k59_281076_1	105559.Nwat_1363	5.19e-49	171.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1WY1X@135613|Chromatiales	135613|Chromatiales	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
k59_441795_1	1035308.AQYY01000001_gene2075	2.3e-17	79.0	COG2361@1|root,COG2361@2|Bacteria	2|Bacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
k59_441795_2	1171373.PACID_21710	5.18e-08	52.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2,PhdYeFM_antitox
k59_1789978_1	479431.Namu_3116	1.82e-51	169.0	arCOG14808@1|root,308PC@2|Bacteria,2IIBU@201174|Actinobacteria,4EV3D@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF4956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4956
k59_48232_1	313589.JNB_13603	3.99e-57	177.0	COG0360@1|root,COG0360@2|Bacteria,2IQHD@201174|Actinobacteria,4FGY5@85021|Intrasporangiaceae	201174|Actinobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
k59_48232_2	367299.JOEE01000001_gene1468	6.55e-79	238.0	COG0629@1|root,COG0629@2|Bacteria,2GMM3@201174|Actinobacteria,4FEK7@85021|Intrasporangiaceae	201174|Actinobacteria	L	Single-stranded DNA-binding protein	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_1505448_1	631362.Thi970DRAFT_02649	4.85e-46	169.0	COG0398@1|root,COG1502@1|root,COG0398@2|Bacteria,COG1502@2|Bacteria,1MV8I@1224|Proteobacteria,1RSB6@1236|Gammaproteobacteria,1WXPA@135613|Chromatiales	135613|Chromatiales	I	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	PLDc,PLDc_2,SNARE_assoc
k59_1867556_1	1304865.JAGF01000001_gene3369	5.35e-30	112.0	COG0515@1|root,COG0515@2|Bacteria,2GTP2@201174|Actinobacteria	201174|Actinobacteria	KLT	Protein of unknown function (DUF3105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3105
k59_859820_1	768671.ThimaDRAFT_4343	2.76e-54	182.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1WWS2@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_938727_1	713586.KB900536_gene2557	3.39e-114	343.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1WWXH@135613|Chromatiales	135613|Chromatiales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1622055_1	626887.J057_20375	5.46e-09	57.0	COG1344@1|root,COG1344@2|Bacteria,1PJUJ@1224|Proteobacteria,1RPNR@1236|Gammaproteobacteria,466JS@72275|Alteromonadaceae	1236|Gammaproteobacteria	N	Belongs to the bacterial flagellin family	flgL	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
k59_1622055_2	396588.Tgr7_1226	5.07e-27	115.0	COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,1RMEA@1236|Gammaproteobacteria,1WW11@135613|Chromatiales	135613|Chromatiales	N	TIGRFAM Flagellar hook-associated protein, FlgK	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
k59_1447861_1	1233950.IW22_23305	2.94e-26	99.8	COG0776@1|root,COG0776@2|Bacteria,4NSK6@976|Bacteroidetes,1I43K@117743|Flavobacteriia,3ZSBA@59732|Chryseobacterium	976|Bacteroidetes	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_1447865_1	1114970.PSF113_2433	1.57e-90	280.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,1RPR3@1236|Gammaproteobacteria,1YNZM@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	FL	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
k59_743431_1	1123065.ATWL01000007_gene3309	4.42e-92	281.0	COG0042@1|root,COG0042@2|Bacteria,2GJ8I@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	GO:0008150,GO:0010565,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0080090	-	-	-	-	-	-	-	-	-	-	Dus
k59_743431_2	1123065.ATWL01000007_gene3306	9.03e-47	155.0	COG5438@1|root,COG5438@2|Bacteria,2GKJ4@201174|Actinobacteria	201174|Actinobacteria	S	YibE F family protein	-	-	-	-	-	-	-	-	-	-	-	-	YibE_F
k59_1031845_1	469383.Cwoe_3622	7.9e-05	45.1	COG0290@1|root,COG0290@2|Bacteria,2GJGT@201174|Actinobacteria,4CQ6T@84995|Rubrobacteria	84995|Rubrobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
k59_1031845_2	880072.Desac_2309	1.93e-106	327.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2WJ2N@28221|Deltaproteobacteria,2MQSY@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_1279269_1	1454004.AW11_00116	1.95e-68	222.0	COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,2VVC6@28216|Betaproteobacteria	28216|Betaproteobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_4
k59_938753_1	215803.DB30_3094	5.53e-44	155.0	COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,42Q9D@68525|delta/epsilon subdivisions,2WK21@28221|Deltaproteobacteria,2YXB7@29|Myxococcales	28221|Deltaproteobacteria	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
k59_938753_2	448385.sce4900	6.5e-65	207.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,42MY6@68525|delta/epsilon subdivisions,2WMDC@28221|Deltaproteobacteria,2YU5V@29|Myxococcales	28221|Deltaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1513442_1	1117943.SFHH103_02485	5.18e-28	110.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2UQRR@28211|Alphaproteobacteria,4BN9U@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1513442_2	1267533.KB906744_gene80	9.37e-07	50.4	COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,3Y3JK@57723|Acidobacteria,2JIZX@204432|Acidobacteriia	204432|Acidobacteriia	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3
k59_1388118_1	502025.Hoch_0163	1.27e-90	277.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,42Q9U@68525|delta/epsilon subdivisions,2X5CC@28221|Deltaproteobacteria,2Z0TN@29|Myxococcales	28221|Deltaproteobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
k59_1388118_2	314287.GB2207_11178	1.89e-53	176.0	28KE4@1|root,2ZA0D@2|Bacteria,1MXZT@1224|Proteobacteria,1RYV4@1236|Gammaproteobacteria,1J6JN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_117068_1	396588.Tgr7_3185	5.57e-229	654.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales	135613|Chromatiales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_743448_1	266834.SMc04227	2.72e-09	63.9	COG0840@1|root,COG4564@1|root,COG0840@2|Bacteria,COG4564@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,4B8S0@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	chemotaxis protein	mcpV	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_2,sCache_2
k59_625092_1	1235835.C814_02338	4.36e-21	99.8	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_2
k59_938772_1	948106.AWZT01000005_gene4527	2.76e-56	189.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2VI3U@28216|Betaproteobacteria,1K2CP@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_58515_1	1110502.TMO_0953	8.54e-06	47.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TRI8@28211|Alphaproteobacteria,2JPIE@204441|Rhodospirillales	204441|Rhodospirillales	S	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
k59_58515_2	301.JNHE01000002_gene2308	2.72e-124	373.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1YFAV@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	G	Belongs to the pyruvate kinase family	pykA	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_1513458_1	671143.DAMO_3066	1.14e-05	48.1	COG0318@1|root,COG0318@2|Bacteria,2NQWW@2323|unclassified Bacteria	2|Bacteria	IQ	AMP-binding enzyme	JD73_00810	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C_2
k59_684771_1	140110.NechaP94964	1.36e-35	136.0	COG1104@1|root,KOG1549@2759|Eukaryota,39V6W@33154|Opisthokonta,3NWXZ@4751|Fungi,3QMGP@4890|Ascomycota,212Y6@147550|Sordariomycetes,3TGXV@5125|Hypocreales,1FSD3@110618|Nectriaceae	4751|Fungi	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_684771_2	1387312.BAUS01000002_gene561	1.67e-32	125.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2VHJ4@28216|Betaproteobacteria,2KKFE@206350|Nitrosomonadales	206350|Nitrosomonadales	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_938782_1	340099.Teth39_0233	2.85e-59	189.0	COG0588@1|root,COG0588@2|Bacteria,1TQFP@1239|Firmicutes,248XG@186801|Clostridia,42FWV@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmA	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
k59_410667_1	1007105.PT7_0088	1.85e-09	64.7	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,1QU90@1224|Proteobacteria,2VHNR@28216|Betaproteobacteria,3T1RI@506|Alcaligenaceae	28216|Betaproteobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	3.1.11.5	ko:K01144	-	-	-	-	ko00000,ko01000	-	-	-	PDDEXK_1
k59_214824_1	1191523.MROS_1977	2.19e-48	176.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	korA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_684788_1	768671.ThimaDRAFT_0239	4.76e-110	346.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,1WW9S@135613|Chromatiales	135613|Chromatiales	E	Bacterial transglutaminase-like N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
k59_58548_1	2340.JV46_18360	7.31e-38	133.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,1RP3R@1236|Gammaproteobacteria,1J54R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	iECDH1ME8569_1439.ECDH1ME8569_2134,iSFV_1184.SFV_2275,iSFxv_1172.SFxv_2517,iUTI89_1310.UTI89_C2477,ic_1306.c2736	Cytochrom_C_asm
k59_58548_2	472759.Nhal_0856	3.48e-29	112.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,1RRFJ@1236|Gammaproteobacteria,1WWPG@135613|Chromatiales	135613|Chromatiales	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
k59_58570_2	631362.Thi970DRAFT_01953	4.56e-87	258.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,1WWE7@135613|Chromatiales	135613|Chromatiales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_684804_1	765912.Thimo_2436	6.11e-18	83.2	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1WXQX@135613|Chromatiales	135613|Chromatiales	L	DNA photolyase	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_1513498_1	1283284.AZUK01000001_gene2324	5.85e-29	112.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,1Y3NM@135624|Aeromonadales	135624|Aeromonadales	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
k59_625139_1	195253.Syn6312_3680	5.04e-11	68.6	COG1295@1|root,COG1295@2|Bacteria,1G3Q3@1117|Cyanobacteria,1GZ2A@1129|Synechococcus	1117|Cyanobacteria	S	Virulence factor BrkB	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
k59_938836_1	666681.M301_1211	1.71e-36	138.0	COG3746@1|root,COG3746@2|Bacteria,1MY3M@1224|Proteobacteria,2VIIP@28216|Betaproteobacteria	28216|Betaproteobacteria	P	phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1104874_2	1249627.D779_4053	2.15e-46	156.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,1S22U@1236|Gammaproteobacteria,1X0RX@135613|Chromatiales	135613|Chromatiales	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_743493_2	1134474.O59_002517	1.79e-195	543.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1S1B0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	-	-	2.5.1.15	ko:K18974	ko00790,ko01100,map00790,map01100	-	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko01000,ko01504	-	-	-	Pterin_bind
k59_743493_3	1177594.MIC448_1230003	5.97e-75	224.0	COG2076@1|root,COG2076@2|Bacteria	2|Bacteria	P	Multidrug Resistance protein	emrE	-	-	ko:K03297,ko:K18975	-	-	-	-	ko00000,ko02000	2.A.7.1,2.A.7.1.11	-	-	Multi_Drug_Res
k59_156580_1	1283300.ATXB01000001_gene1045	8.91e-56	188.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1XE5N@135618|Methylococcales	135618|Methylococcales	C	Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7
k59_1513510_1	1347392.CCEZ01000007_gene2134	9.87e-79	246.0	COG1494@1|root,COG1494@2|Bacteria,1TP0D@1239|Firmicutes,249PW@186801|Clostridia,36E1S@31979|Clostridiaceae	186801|Clostridia	G	Fructose-1,6-bisphosphatase	glpX	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
k59_566540_1	97139.C824_04483	0.000274	48.5	COG2148@1|root,COG2148@2|Bacteria,1TP49@1239|Firmicutes,249F1@186801|Clostridia,36DJ2@31979|Clostridiaceae	186801|Clostridia	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
k59_1563955_1	1463879.JOHP01000015_gene4652	2.96e-08	55.1	COG0561@1|root,COG0561@2|Bacteria	2|Bacteria	Q	phosphatase activity	supH	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
k59_1563955_2	666681.M301_0545	7.62e-08	56.6	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,2VHMU@28216|Betaproteobacteria,2KP6A@206350|Nitrosomonadales	206350|Nitrosomonadales	O	DnaJ molecular chaperone homology domain	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
k59_684825_1	1094184.KWO_0121990	3.63e-22	89.0	COG3052@1|root,COG3052@2|Bacteria,1N71C@1224|Proteobacteria,1SG3Y@1236|Gammaproteobacteria,1X8BD@135614|Xanthomonadales	135614|Xanthomonadales	C	Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism	mdcC	-	-	ko:K13931	-	-	-	-	ko00000,ko02000	3.B.1.1.4	-	-	ACP
k59_684825_2	1144319.PMI16_05014	4.74e-54	183.0	COG1788@1|root,COG1788@2|Bacteria,1R1R7@1224|Proteobacteria,2WI4N@28216|Betaproteobacteria,4727J@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	malonate decarboxylase, alpha subunit	mdcA	-	2.3.1.187	ko:K13929	-	-	R08944	RC00012,RC00014	ko00000,ko01000,ko02000	3.B.1.1.4	-	-	Mal_decarbox_Al
k59_938875_1	1049564.TevJSym_ad00070	4.9e-123	369.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1J4XI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_1149412_1	1121943.KB899999_gene1372	1.48e-26	105.0	COG1136@1|root,COG1136@2|Bacteria,1NCFC@1224|Proteobacteria,1S18G@1236|Gammaproteobacteria,1XR7I@135619|Oceanospirillales	135619|Oceanospirillales	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_1149412_2	472759.Nhal_1408	1.2e-31	126.0	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,1RNP1@1236|Gammaproteobacteria,1WWFF@135613|Chromatiales	135613|Chromatiales	V	ABC-type transport system, involved in lipoprotein release, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_156594_1	1454004.AW11_03580	1.42e-94	291.0	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VHA3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Phospholipase, patatin family	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_1740713_1	360910.BAV1945	6.98e-43	165.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VIZZ@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Domain of unknown function (DUF4347)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,DUF4347
k59_743516_1	501479.ACNW01000062_gene2740	9.95e-45	160.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_1796587_2	1121374.KB891585_gene1950	1.46e-80	254.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL
k59_1149413_1	1144319.PMI16_00398	9.09e-13	73.2	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,472UU@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	iorB1	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_1279362_1	283942.IL1698	6.02e-82	264.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,2QF8S@267893|Idiomarinaceae	1236|Gammaproteobacteria	M	transglycosylase	mltD	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_58642_2	941449.dsx2_0771	1.19e-11	65.1	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,42SCQ@68525|delta/epsilon subdivisions,2WPZQ@28221|Deltaproteobacteria,2MAU8@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
k59_1622160_1	290400.Jann_2550	7.94e-47	160.0	COG5012@1|root,COG5012@2|Bacteria,1RDEU@1224|Proteobacteria,2TVXN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	cobalamin binding protein	mtbC	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
k59_332413_1	754476.Q7A_2063	3.42e-166	474.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,1RNZZ@1236|Gammaproteobacteria,4600E@72273|Thiotrichales	72273|Thiotrichales	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_332413_2	472759.Nhal_0872	1.06e-87	265.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,1RMHS@1236|Gammaproteobacteria,1WY1C@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
k59_332413_3	754476.Q7A_2065	4.47e-41	148.0	COG3170@1|root,COG3170@2|Bacteria,1RDXQ@1224|Proteobacteria,1T42I@1236|Gammaproteobacteria,460XW@72273|Thiotrichales	72273|Thiotrichales	NU	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
k59_1513548_1	1038922.PflQ2_4214	6.48e-24	101.0	COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,1S4TG@1236|Gammaproteobacteria,1YNNB@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	G	6-phosphogluconolactonase	pgl	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
k59_566575_1	644801.Psest_3724	1.46e-112	349.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1Z0AH@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_1622169_1	443144.GM21_3463	1.22e-59	200.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA-2	GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Alpha-amylase,Glyco_transf_5,Glycos_transf_1
k59_1031989_1	1240350.AMZE01000004_gene2440	3.57e-07	53.1	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,1S9Q1@1236|Gammaproteobacteria,1YVP8@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	MobA-like NTP transferase domain	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
k59_291267_1	1267005.KB911255_gene2983	3.81e-97	301.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TQRZ@28211|Alphaproteobacteria,3N6FH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ABC transporter	yheS	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_1212767_1	1031711.RSPO_c02845	2.19e-55	182.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2VHGK@28216|Betaproteobacteria,1K4AM@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
k59_795151_2	765910.MARPU_03445	0.000552	39.3	COG3205@1|root,COG3205@2|Bacteria,1N85D@1224|Proteobacteria,1SCCN@1236|Gammaproteobacteria,1WZ8X@135613|Chromatiales	135613|Chromatiales	S	Predicted membrane protein (DUF2061)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2061
k59_567739_1	1265313.HRUBRA_00800	3.93e-68	220.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1J5FS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	MacB-like periplasmic core domain	VP1997	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_450525_1	1047013.AQSP01000064_gene1482	2.4e-79	249.0	COG0104@1|root,COG0104@2|Bacteria,2NNYU@2323|unclassified Bacteria	2|Bacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_1389319_1	1082705.JIBP01000007_gene1289	1.51e-07	57.8	COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,1RMJ1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Belongs to the 'phage' integrase family	Z012_11675	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase
k59_293097_1	765913.ThidrDRAFT_2188	8.04e-108	345.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales	135613|Chromatiales	E	glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_215976_1	1049564.TevJSym_ad00270	4.9e-106	322.0	COG1008@1|root,COG1008@2|Bacteria,1R6UV@1224|Proteobacteria,1S0HQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	overlaps another CDS with the same product name	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1106443_1	1116472.MGMO_84c00070	2.11e-73	229.0	COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria,1S58J@1236|Gammaproteobacteria,1XG72@135618|Methylococcales	135618|Methylococcales	D	Cellulose biosynthesis protein BcsQ	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
k59_626496_1	338969.Rfer_0318	1.24e-77	248.0	COG2303@1|root,COG2303@2|Bacteria,1NV3A@1224|Proteobacteria,2VMNU@28216|Betaproteobacteria	28216|Betaproteobacteria	E	GMC oxidoreductase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_293100_1	395493.BegalDRAFT_3230	4.18e-57	183.0	COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,460DN@72273|Thiotrichales	72273|Thiotrichales	L	Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis	rnt	-	-	ko:K03683	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_T
k59_1742068_1	365046.Rta_17260	1.69e-31	118.0	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,2VMD6@28216|Betaproteobacteria,4ACVC@80864|Comamonadaceae	28216|Betaproteobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60,4.6.1.12	ko:K00991,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
k59_1742068_2	1121015.N789_02015	3.67e-25	97.1	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,1X5Z0@135614|Xanthomonadales	135614|Xanthomonadales	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
k59_1397429_1	1278309.KB907099_gene2469	1.67e-10	66.6	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XHGD@135619|Oceanospirillales	135619|Oceanospirillales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9
k59_634049_1	1454010.JEOE01000021_gene2511	1.88e-17	76.6	COG0736@1|root,COG0736@2|Bacteria,2IQF6@201174|Actinobacteria,4F2JV@85016|Cellulomonadaceae	201174|Actinobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
k59_634049_2	1227261.HMPREF0043_00885	3.22e-60	205.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2GJHB@201174|Actinobacteria,4D3EG@85005|Actinomycetales	201174|Actinobacteria	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
k59_1222461_1	522306.CAP2UW1_2978	2.82e-55	181.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_1222461_2	1550073.JROH01000052_gene3082	1.31e-10	60.1	COG3917@1|root,COG3917@2|Bacteria,1MV6E@1224|Proteobacteria,2TVJ4@28211|Alphaproteobacteria,2K0YH@204457|Sphingomonadales	204457|Sphingomonadales	Q	2-hydroxychromene-2-carboxylate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
k59_693664_1	396588.Tgr7_1159	9.58e-57	183.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,1RN0Z@1236|Gammaproteobacteria,1WW47@135613|Chromatiales	135613|Chromatiales	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_1525218_1	1210046.B277_11395	2.97e-164	484.0	COG1251@1|root,COG1251@2|Bacteria,2GJ3U@201174|Actinobacteria,4FF81@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	nirB	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
k59_870285_1	1173020.Cha6605_5356	2.17e-26	107.0	COG3666@1|root,COG3666@2|Bacteria,1GEUC@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1157476_1	754476.Q7A_2829	1.76e-85	264.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,4602E@72273|Thiotrichales	72273|Thiotrichales	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
k59_457642_1	471853.Bcav_1713	1.15e-99	307.0	COG3266@1|root,COG3266@2|Bacteria,2I44K@201174|Actinobacteria	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_870287_1	187272.Mlg_0809	1.9e-102	301.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,1WW35@135613|Chromatiales	135613|Chromatiales	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_1804373_1	1049564.TevJSym_bc00360	1.06e-213	595.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,1RNTJ@1236|Gammaproteobacteria,1JB7M@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
k59_1042879_1	1279009.ADICEAN_03421	2.92e-96	297.0	COG1032@1|root,COG1032@2|Bacteria,4NFPW@976|Bacteroidetes,47N80@768503|Cytophagia	976|Bacteroidetes	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
k59_1457885_1	1120959.ATXF01000012_gene3189	3.71e-57	198.0	COG0620@1|root,COG0620@2|Bacteria,2GIXA@201174|Actinobacteria,4FKBX@85023|Microbacteriaceae	201174|Actinobacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	metE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0040007,GO:0042084,GO:0042085,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050667,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_1,Meth_synt_2
k59_693683_1	1268622.AVS7_00495	1.03e-06	52.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2VHD0@28216|Betaproteobacteria,4A9M0@80864|Comamonadaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_693683_2	859657.RPSI07_1373	1.45e-08	58.2	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,1JZXQ@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NADH-quinone oxidoreductase	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_752986_2	631362.Thi970DRAFT_00378	1.66e-32	130.0	COG5380@1|root,COG5380@2|Bacteria,1N6UY@1224|Proteobacteria,1S03R@1236|Gammaproteobacteria,1WX19@135613|Chromatiales	135613|Chromatiales	O	lipid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_752986_3	1366050.N234_03440	6.33e-39	142.0	COG0628@1|root,COG0628@2|Bacteria,1R5W4@1224|Proteobacteria,2VM0C@28216|Betaproteobacteria,1K34V@119060|Burkholderiaceae	28216|Betaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_516002_1	1128421.JAGA01000004_gene2610	1.45e-104	317.0	COG2225@1|root,COG2225@2|Bacteria	2|Bacteria	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	aceB	GO:0003674,GO:0003824,GO:0004474,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044424,GO:0044464,GO:0046487,GO:0046912,GO:0071704	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_4499,iLF82_1304.LF82_0013,iNRG857_1313.NRG857_20010	Malate_synthase
k59_1457892_1	999141.GME_17022	7.19e-37	138.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1XHB9@135619|Oceanospirillales	135619|Oceanospirillales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_1457892_2	713586.KB900536_gene2731	1.45e-25	98.6	COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,1RP6W@1236|Gammaproteobacteria,1WX8R@135613|Chromatiales	135613|Chromatiales	I	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length	fabA	-	4.2.1.59,5.3.3.14	ko:K01716	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639	RC00831,RC01078,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
k59_1692787_1	1244869.H261_03968	1.38e-09	63.5	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,2TV2G@28211|Alphaproteobacteria,2JRYP@204441|Rhodospirillales	204441|Rhodospirillales	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	DUF3305,NTP_transf_3
k59_1692787_2	1123401.JHYQ01000007_gene545	9.06e-20	94.4	COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,1T214@1236|Gammaproteobacteria,461U9@72273|Thiotrichales	72273|Thiotrichales	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3306,Fer4
k59_1692787_3	553385.JEMF01000099_gene1639	1.8e-20	98.2	COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,1T214@1236|Gammaproteobacteria,1XI74@135619|Oceanospirillales	135619|Oceanospirillales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
k59_166020_1	1089545.KB913037_gene5915	5.71e-58	203.0	COG3250@1|root,COG3250@2|Bacteria,2I9Q2@201174|Actinobacteria,4EAA4@85010|Pseudonocardiales	201174|Actinobacteria	G	Ricin-type beta-trefoil lectin domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,RicinB_lectin_2
k59_1222489_2	1236959.BAMT01000010_gene3264	2.18e-63	195.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,2VSI3@28216|Betaproteobacteria,2KMXA@206350|Nitrosomonadales	206350|Nitrosomonadales	C	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q4
k59_1804382_1	519989.ECTPHS_06922	8.02e-67	206.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,1S3PT@1236|Gammaproteobacteria,1WX50@135613|Chromatiales	135613|Chromatiales	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
k59_693693_2	2340.JV46_26150	2.09e-86	258.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1J4YR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EH	COG0512 Anthranilate para-aminobenzoate synthases component II	pabA	GO:0000162,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_3095,iEC042_1314.EC042_3623,iECABU_c1320.ECABU_c37840,iECED1_1282.ECED1_4024,iECNA114_1301.ECNA114_3463,iECOK1_1307.ECOK1_3780,iECP_1309.ECP_3451,iECS88_1305.ECS88_3751,iECSF_1327.ECSF_3187,iLF82_1304.LF82_1586,iNRG857_1313.NRG857_16660,iUMN146_1321.UM146_16880,iUTI89_1310.UTI89_C3863,ic_1306.c4135	GATase
k59_1222496_1	247634.GPB2148_498	9.01e-59	206.0	COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,1S52W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C
k59_1457909_1	1121405.dsmv_2103	1.45e-37	145.0	COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,42NGA@68525|delta/epsilon subdivisions,2WJK3@28221|Deltaproteobacteria,2MJ23@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	TIGRFAM Polyketide-type polyunsaturated fatty acid synthase, PfaA	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,FabA,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
k59_802088_1	1123228.AUIH01000002_gene1522	1.19e-46	159.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1XH75@135619|Oceanospirillales	135619|Oceanospirillales	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_802088_2	399795.CtesDRAFT_PD3245	6.77e-35	131.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2VH0Z@28216|Betaproteobacteria,4AAXS@80864|Comamonadaceae	28216|Betaproteobacteria	S	Peptidogalycan biosysnthesis/recognition	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
k59_693714_1	288000.BBta_6892	3.14e-62	204.0	28NXH@1|root,2ZBV3@2|Bacteria,1RDDP@1224|Proteobacteria,2U1V5@28211|Alphaproteobacteria,3JWJZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1157512_1	96561.Dole_0668	4.25e-73	224.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,42RVP@68525|delta/epsilon subdivisions,2WNCX@28221|Deltaproteobacteria,2MJVF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Appr-1-p processing domain protein	ymdB	-	-	-	-	-	-	-	-	-	-	-	Macro
k59_224149_1	999141.GME_18363	2.09e-28	114.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XI69@135619|Oceanospirillales	135619|Oceanospirillales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1157515_1	1121933.AUHH01000002_gene1855	1.35e-38	140.0	COG0042@1|root,COG0042@2|Bacteria,2GJ8I@201174|Actinobacteria,4DNZA@85009|Propionibacteriales	201174|Actinobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	GO:0008150,GO:0010565,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0080090	-	-	-	-	-	-	-	-	-	-	Dus
k59_458840_1	1033802.SSPSH_002348	4.06e-135	395.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iUTI89_1310.UTI89_C0772,iZ_1308.Z0993	Aminotran_3
k59_1398851_1	1122951.ATUE01000008_gene215	1.33e-100	323.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,3NJS6@468|Moraxellaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1750931_1	309807.SRU_0899	4.51e-21	93.2	COG0733@1|root,COG0733@2|Bacteria,4NGQ5@976|Bacteroidetes,1FJPU@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_1750931_2	493475.GARC_0757	4.43e-36	132.0	COG3268@1|root,COG3268@2|Bacteria,1MVI3@1224|Proteobacteria,1RSCK@1236|Gammaproteobacteria,463XY@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Saccharopine dehydrogenase	lys	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
k59_1158653_1	765913.ThidrDRAFT_1882	1.06e-16	79.7	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,1WWUF@135613|Chromatiales	135613|Chromatiales	S	PFAM Patatin	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_1158653_2	870187.Thini_3697	2.87e-111	336.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,45ZYG@72273|Thiotrichales	72273|Thiotrichales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1805500_1	349521.HCH_00947	5.52e-06	53.9	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1T23Q@1236|Gammaproteobacteria,1XRKI@135619|Oceanospirillales	135619|Oceanospirillales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_803248_1	1110502.TMO_0959	1.18e-13	75.5	COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,2U0C9@28211|Alphaproteobacteria,2JR94@204441|Rhodospirillales	204441|Rhodospirillales	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
k59_1750939_1	768671.ThimaDRAFT_3002	1.88e-121	382.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RMPV@1236|Gammaproteobacteria,1WW6H@135613|Chromatiales	135613|Chromatiales	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_1633508_1	590998.Celf_2311	1.23e-85	272.0	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria	201174|Actinobacteria	G	alpha amylase, catalytic	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_1398872_1	314607.KB13_272	0.00059	44.7	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,2VIDH@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K18306	ko02024,map02024	M00644	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2.20,2.A.6.2.32,8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1398872_2	1384054.N790_00805	4.47e-90	295.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X3PQ@135614|Xanthomonadales	135614|Xanthomonadales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	mdtB	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_694950_1	765914.ThisiDRAFT_2319	6.35e-41	153.0	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,1RQZJ@1236|Gammaproteobacteria,1WYXF@135613|Chromatiales	135613|Chromatiales	I	PFAM membrane protein involved in aromatic hydrocarbon degradation	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_1044572_2	68260.JOAY01000031_gene3129	8.75e-44	147.0	COG1487@1|root,COG1487@2|Bacteria,2IS29@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07062	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
k59_803258_1	675812.VHA_001341	2.04e-38	149.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,1XVNX@135623|Vibrionales	135623|Vibrionales	M	Small-conductance mechanosensitive channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel
k59_754417_1	153948.NAL212_2617	1.35e-40	138.0	COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,2VN9B@28216|Betaproteobacteria,371TV@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_754417_2	1249627.D779_1392	8.04e-109	332.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1WVWH@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_516938_1	204773.HEAR1237	8.37e-88	275.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,472GV@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_343103_1	396014.BF93_04970	1.14e-33	120.0	COG0054@1|root,COG0054@2|Bacteria,2II1Z@201174|Actinobacteria,4FCTM@85020|Dermabacteraceae	201174|Actinobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0040007,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
k59_343103_2	928724.SacglDRAFT_01790	6.4e-60	197.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2GIWJ@201174|Actinobacteria,4DXCJ@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	GO:0005575,GO:0005576,GO:0008150,GO:0040007	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1415	DHBP_synthase,GTP_cyclohydro2
k59_1633533_1	909943.HIMB100_00014610	1.02e-39	148.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2TTPX@28211|Alphaproteobacteria,4BT8J@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Molydopterin dinucleotide binding domain	fdhF	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1044595_1	1123065.ATWL01000001_gene453	1.66e-261	763.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,2GN09@201174|Actinobacteria	201174|Actinobacteria	E	Glutamate synthase	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1459264_1	926569.ANT_10070	5.43e-131	376.0	COG0090@1|root,COG0090@2|Bacteria,2G65E@200795|Chloroflexi	200795|Chloroflexi	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_1459273_1	350054.Mflv_5132	1.69e-30	124.0	COG0392@1|root,COG0392@2|Bacteria,2GMAV@201174|Actinobacteria,234XJ@1762|Mycobacteriaceae	201174|Actinobacteria	T	integral membrane protein	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
k59_694984_1	697281.Mahau_1317	3.27e-11	62.8	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42FF9@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_694984_2	240016.ABIZ01000001_gene3213	2.2e-44	154.0	COG0332@1|root,COG0332@2|Bacteria,46SE2@74201|Verrucomicrobia,2ITMR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_871994_1	247634.GPB2148_2206	9.28e-31	123.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVS@1236|Gammaproteobacteria,1J55S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA
k59_871994_2	1279017.AQYJ01000022_gene2614	5.33e-12	65.9	COG0457@1|root,COG0457@2|Bacteria,1RC07@1224|Proteobacteria,1S36N@1236|Gammaproteobacteria,46864@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
k59_1805545_1	998674.ATTE01000001_gene356	6.49e-119	347.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,4606Q@72273|Thiotrichales	72273|Thiotrichales	L	Exodeoxyribonuclease III xth	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_1805545_2	472759.Nhal_0455	2.87e-81	260.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1WW1J@135613|Chromatiales	135613|Chromatiales	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	-	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_225565_1	1499680.CCFE01000031_gene3716	2.05e-30	120.0	COG0549@1|root,COG0549@2|Bacteria,1TP9H@1239|Firmicutes,4H9QD@91061|Bacilli,1ZB4U@1386|Bacillus	91061|Bacilli	E	Belongs to the carbamate kinase family	cpkA	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_1750986_1	497964.CfE428DRAFT_0593	8.88e-56	191.0	COG3666@1|root,COG3666@2|Bacteria,46S8M@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1805547_1	1120956.JHZK01000001_gene3397	3.53e-28	109.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,2U1SQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
k59_1805547_2	768671.ThimaDRAFT_2820	1.9e-42	147.0	COG3713@1|root,COG3713@2|Bacteria,1N0BC@1224|Proteobacteria	1224|Proteobacteria	M	MltA-interacting MipA family protein	-	-	-	ko:K07274	-	-	-	-	ko00000,ko02000	9.B.99.1	-	-	MipA
k59_803306_1	1121430.JMLG01000001_gene2338	1.36e-87	278.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia,2605J@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.5,1.8.5.6	ko:K08352,ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R10149,R11487	RC00168,RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_343145_1	1038869.AXAN01000046_gene4377	3.13e-17	88.2	COG0745@1|root,COG0784@1|root,COG4191@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2W1GP@28216|Betaproteobacteria,1K0TI@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,Response_reg
k59_1044649_1	313589.JNB_19343	2.47e-116	345.0	COG0174@1|root,COG0174@2|Bacteria,2GM3K@201174|Actinobacteria,4FETN@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the glutamine synthetase family	glnA4	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_225579_1	472759.Nhal_2058	5.13e-78	252.0	COG1305@1|root,COG1305@2|Bacteria,1MVV3@1224|Proteobacteria,1RRIA@1236|Gammaproteobacteria,1X0CC@135613|Chromatiales	135613|Chromatiales	E	7 transmembrane helices usually fused to an inactive transglutaminase	-	-	-	-	-	-	-	-	-	-	-	-	7TM_transglut,Transglut_i_TM
k59_1158727_2	187272.Mlg_2132	2.82e-29	116.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales	135613|Chromatiales	E	Vitamin B12 dependent methionine synthase activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_1750997_1	392499.Swit_5131	2.58e-39	139.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TS16@28211|Alphaproteobacteria,2K22R@204457|Sphingomonadales	204457|Sphingomonadales	L	COG1484 DNA replication protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_1750997_2	1121438.JNJA01000007_gene1627	7.31e-67	214.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42SM4@68525|delta/epsilon subdivisions,2WPVD@28221|Deltaproteobacteria,2MGHY@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1641829_1	367299.JOEE01000004_gene1022	1.28e-88	283.0	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4FFTS@85021|Intrasporangiaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 65, C-terminal domain	-	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
k59_1467447_1	1454010.JEOE01000005_gene1647	2.46e-105	319.0	COG0617@1|root,COG0617@2|Bacteria,2GMT1@201174|Actinobacteria,4F0T3@85016|Cellulomonadaceae	201174|Actinobacteria	J	metal-dependent phosphohydrolase HD sub domain	pcnA	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
k59_643868_1	367299.JOEE01000001_gene1529	3.56e-114	333.0	COG0656@1|root,COG0656@2|Bacteria,2GJQ7@201174|Actinobacteria,4FEXY@85021|Intrasporangiaceae	201174|Actinobacteria	S	Aldo/keto reductase family	dkgA	-	1.1.1.346	ko:K06221	-	-	R08878	RC00089	ko00000,ko01000	-	-	-	Aldo_ket_red
k59_643868_2	367299.JOEE01000002_gene2241	1.02e-15	75.5	COG1387@1|root,COG1387@2|Bacteria,2GMFH@201174|Actinobacteria,4FE7U@85021|Intrasporangiaceae	201174|Actinobacteria	E	Helix-hairpin-helix domain	polX	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	HHH_8,PHP
k59_469500_1	1249627.D779_3956	1.19e-140	413.0	COG0189@1|root,COG0454@1|root,COG0189@2|Bacteria,COG0456@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria,1WWH7@135613|Chromatiales	135613|Chromatiales	HJ	ATP-grasp	-	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,RimK
k59_643873_1	1313304.CALK_1232	5.26e-18	82.8	COG0101@1|root,COG0101@2|Bacteria	2|Bacteria	J	tRNA pseudouridine synthase activity	truA	GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_819945_1	479431.Namu_2326	1.61e-269	746.0	COG4320@1|root,COG4320@2|Bacteria,2GKEK@201174|Actinobacteria,4ETQ2@85013|Frankiales	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
k59_820018_1	1265505.ATUG01000001_gene3026	1.42e-81	270.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_820092_1	1283299.AUKG01000001_gene3194	1.4e-22	99.4	COG2804@1|root,COG2804@2|Bacteria,2I8C2@201174|Actinobacteria,4CS5C@84995|Rubrobacteria	84995|Rubrobacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE,T2SSE_N
k59_820119_1	1415779.JOMH01000001_gene3147	1.67e-51	187.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1X527@135614|Xanthomonadales	135614|Xanthomonadales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_820198_1	519989.ECTPHS_07242	3.69e-143	419.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales	135613|Chromatiales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_820218_1	196164.23493233	1.91e-21	88.2	COG1320@1|root,COG1320@2|Bacteria,2HTMK@201174|Actinobacteria,22QPV@1653|Corynebacteriaceae	201174|Actinobacteria	P	Na+/H+ antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_820218_2	318167.Sfri_2738	3.01e-07	53.5	COG1563@1|root,COG1563@2|Bacteria,1N7YY@1224|Proteobacteria,1SHR3@1236|Gammaproteobacteria,2QE6E@267890|Shewanellaceae	1236|Gammaproteobacteria	P	Domain of unknown function (DUF4040)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4040
k59_820243_1	936455.KI421499_gene8165	4.93e-19	87.4	COG1196@1|root,COG4717@1|root,COG1196@2|Bacteria,COG4717@2|Bacteria,1MVAW@1224|Proteobacteria,2TTMD@28211|Alphaproteobacteria,3JXFP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_27
k59_820262_2	572477.Alvin_2358	2.71e-44	146.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,1S5XT@1236|Gammaproteobacteria,1WYH7@135613|Chromatiales	135613|Chromatiales	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_820262_3	1049564.TevJSym_aa00080	1.62e-12	65.1	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,1J4GK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0000028,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_820429_1	266748.HY04_00970	1.27e-67	221.0	COG1012@1|root,COG1012@2|Bacteria,4NFPJ@976|Bacteroidetes,1HX3I@117743|Flavobacteriia,3ZQAN@59732|Chryseobacterium	976|Bacteroidetes	C	Belongs to the aldehyde dehydrogenase family	pcd	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_820564_1	590998.Celf_3030	1.11e-119	375.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4F0YF@85016|Cellulomonadaceae	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_820703_1	765912.Thimo_0084	1.18e-38	135.0	COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,1S3S0@1236|Gammaproteobacteria,1WY4Z@135613|Chromatiales	135613|Chromatiales	NU	PFAM Fimbrial assembly	-	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
k59_820703_2	349521.HCH_05972	1.02e-13	71.2	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1XH3V@135619|Oceanospirillales	135619|Oceanospirillales	NU	Pilus assembly protein	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_820711_1	768671.ThimaDRAFT_0364	7.08e-85	266.0	COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,1RNUM@1236|Gammaproteobacteria,1WW3E@135613|Chromatiales	135613|Chromatiales	S	Deoxyribodipyrimidine photo-lyase-related protein	-	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP
k59_820800_1	112098.XP_008614743.1	1.04e-28	119.0	COG0265@1|root,KOG1421@2759|Eukaryota	2759|Eukaryota	O	serine-type endopeptidase activity	DEG7	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009314,GO:0009416,GO:0009507,GO:0009536,GO:0009628,GO:0009642,GO:0009644,GO:0009892,GO:0010109,GO:0010205,GO:0016787,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0042548,GO:0043155,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043467,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0071704,GO:0140096,GO:1901564,GO:1905156	-	-	-	-	-	-	-	-	-	-	PDZ_1,PDZ_2,Trypsin_2
k59_820844_1	1713.JOFV01000008_gene3256	2.44e-141	423.0	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria,4F26G@85016|Cellulomonadaceae	201174|Actinobacteria	G	Alpha-amylase domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_820896_1	713586.KB900537_gene3266	3.43e-12	64.3	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,1X10Z@135613|Chromatiales	135613|Chromatiales	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	-	-	-	-	-	-	-	-	-	SSB
k59_820965_1	1380387.JADM01000004_gene3075	9.92e-67	218.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RSN1@1236|Gammaproteobacteria,1XIFM@135619|Oceanospirillales	135619|Oceanospirillales	I	COG1398 Fatty-acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,FA_desaturase
k59_820977_1	1120998.AUFC01000014_gene1662	2.75e-05	51.6	COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,1UYU1@1239|Firmicutes,248FM@186801|Clostridia	186801|Clostridia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD,HD_5,PAS
k59_821008_1	765420.OSCT_0100	7.3e-47	161.0	COG1028@1|root,COG1028@2|Bacteria,2G8G1@200795|Chloroflexi,376VW@32061|Chloroflexia	32061|Chloroflexia	IQ	short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_821009_1	1121405.dsmv_1080	9.06e-85	258.0	COG0755@1|root,COG0755@2|Bacteria,1RG6M@1224|Proteobacteria,43BH8@68525|delta/epsilon subdivisions,2X6VM@28221|Deltaproteobacteria,2MPIN@213118|Desulfobacterales	28221|Deltaproteobacteria	O	TIGRFAM cytochrome c-type biogenesis protein CcsB	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
k59_821136_1	266264.Rmet_1517	4.35e-97	293.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,2VHJ3@28216|Betaproteobacteria,1K4K1@119060|Burkholderiaceae	28216|Betaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Mannitol_dh_C
k59_821136_2	62928.azo0196	4.09e-06	48.5	COG2378@1|root,COG2378@2|Bacteria,1P2ZE@1224|Proteobacteria,2VMDI@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Helix-turn-helix type 11	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
k59_821166_1	1042375.AFPL01000036_gene2997	3.05e-186	536.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,1RPGT@1236|Gammaproteobacteria,465WE@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	acsA	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_821232_1	765910.MARPU_12150	8.25e-85	259.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales	135613|Chromatiales	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
k59_821232_2	1049564.TevJSym_aa00800	1.04e-76	240.0	COG0596@1|root,COG0596@2|Bacteria,1QUBR@1224|Proteobacteria,1RSF9@1236|Gammaproteobacteria,1J6DZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters	bioH	GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016787,GO:0016788,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0052689,GO:0071704,GO:0072330,GO:0090499,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.1.85	ko:K02170	ko00780,ko01100,map00780,map01100	M00572	R09725	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	iBWG_1329.BWG_3103,iECBD_1354.ECBD_0333,iECDH10B_1368.ECDH10B_3587,iECDH1ME8569_1439.ECDH1ME8569_3291,iETEC_1333.ETEC_3662,iEcDH1_1363.EcDH1_0301,iJO1366.b3412,iY75_1357.Y75_RS20155	Abhydrolase_1,Abhydrolase_6
k59_821232_3	765911.Thivi_1763	4.66e-31	120.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1WVW0@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_821250_1	224914.BMEII0560	4.99e-49	159.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,2U9BY@28211|Alphaproteobacteria,1J320@118882|Brucellaceae	28211|Alphaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
k59_821315_1	62928.azo0810	4.45e-32	121.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,2VR85@28216|Betaproteobacteria,2KW7C@206389|Rhodocyclales	206389|Rhodocyclales	Q	ABC-type transport system involved in resistance to organic solvents, auxiliary component	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
k59_821484_1	768671.ThimaDRAFT_4428	1e-173	492.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,1WZPM@135613|Chromatiales	135613|Chromatiales	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_821528_1	1192124.LIG30_4012	7.04e-62	201.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VI81@28216|Betaproteobacteria,1JZUI@119060|Burkholderiaceae	28216|Betaproteobacteria	V	ABC transporter	ybhF_1	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_821558_1	1123247.AUIJ01000002_gene2171	7.36e-68	226.0	COG0348@1|root,COG3901@1|root,COG0348@2|Bacteria,COG3901@2|Bacteria,1MY5M@1224|Proteobacteria,2TR0X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CK	COG3901 Regulator of nitric oxide reductase transcription	nosR	-	-	ko:K19339	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind,Fer4_5
k59_821576_1	631362.Thi970DRAFT_04731	3.67e-53	188.0	COG0466@1|root,COG0466@2|Bacteria,1NTR5@1224|Proteobacteria,1RPID@1236|Gammaproteobacteria,1WWG2@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_821618_2	367299.JOEE01000009_gene239	1.02e-184	517.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4FFXF@85021|Intrasporangiaceae	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	nodI	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
k59_821674_1	84588.SYNW0985	6.78e-41	155.0	COG2931@1|root,COG3209@1|root,COG3898@1|root,COG5625@1|root,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3898@2|Bacteria,COG5625@2|Bacteria,1GJ0A@1117|Cyanobacteria,1H18T@1129|Synechococcus	1117|Cyanobacteria	Q	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347
k59_821687_1	393595.ABO_2584	1.12e-40	154.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1XIVW@135619|Oceanospirillales	135619|Oceanospirillales	EQ	N-methylhydantoinase A acetone carboxylase, beta subunit	hyuA	-	3.5.2.14,3.5.2.9	ko:K01469,ko:K01473	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00251,R03187	RC00553,RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_821726_2	76114.ebA5132	2.07e-72	222.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2VIJ2@28216|Betaproteobacteria,2KVRX@206389|Rhodocyclales	206389|Rhodocyclales	C	COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit	-	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
k59_821763_1	1267005.KB911265_gene3586	8.12e-72	232.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2TQPV@28211|Alphaproteobacteria,3N68W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_821852_1	1492922.GY26_16945	8.43e-53	172.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1JAGB@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Ami_2	ampD	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043170,GO:0044424,GO:0044464,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	3.5.1.28	ko:K01447,ko:K03806	-	-	R04112	RC00064,RC00141	ko00000,ko01000,ko01011	-	-	iAF1260.b0110,iB21_1397.B21_00108,iBWG_1329.BWG_0103,iEC55989_1330.EC55989_0103,iECBD_1354.ECBD_3509,iECB_1328.ECB_00109,iECDH10B_1368.ECDH10B_0090,iECDH1ME8569_1439.ECDH1ME8569_0104,iECD_1391.ECD_00109,iECIAI1_1343.ECIAI1_0107,iECO103_1326.ECO103_0110,iECO111_1330.ECO111_0111,iECO26_1355.ECO26_0112,iECSE_1348.ECSE_0110,iECW_1372.ECW_m0107,iEKO11_1354.EKO11_3806,iETEC_1333.ETEC_0106,iEcDH1_1363.EcDH1_3492,iEcE24377_1341.EcE24377A_0112,iEcHS_1320.EcHS_A0114,iEcolC_1368.EcolC_3549,iJO1366.b0110,iSFV_1184.SFV_0101,iSF_1195.SF0107,iSFxv_1172.SFxv_0113,iS_1188.S0109,iUMNK88_1353.UMNK88_108,iWFL_1372.ECW_m0107,iY75_1357.Y75_RS00560	Amidase_2
k59_821871_1	367299.JOEE01000004_gene973	4.07e-158	479.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4FE2X@85021|Intrasporangiaceae	201174|Actinobacteria	C	part of alternative pathway from alpha-ketoglutarate to succinate	kgd	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1248c	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_235758_2	1283300.ATXB01000001_gene1278	1.01e-44	149.0	COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,1XEYS@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0234 family	-	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
k59_998938_1	335543.Sfum_3090	8.27e-65	205.0	COG1309@1|root,COG1309@2|Bacteria,1MYVR@1224|Proteobacteria,42SV2@68525|delta/epsilon subdivisions,2WPSA@28221|Deltaproteobacteria,2MRSZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Transcriptional regulator, TetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1233673_1	367299.JOEE01000004_gene1250	2.42e-83	256.0	COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria,4FEDD@85021|Intrasporangiaceae	201174|Actinobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C,TruB_C_2,TruB_N
k59_1174955_1	323098.Nwi_1973	2.7e-83	253.0	COG0265@1|root,COG0265@2|Bacteria,1R40X@1224|Proteobacteria,2UEZS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
k59_176952_1	933262.AXAM01000004_gene2387	2.73e-26	100.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,4375Q@68525|delta/epsilon subdivisions,2X23D@28221|Deltaproteobacteria,2MMCJ@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Glutaredoxin	-	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
k59_176952_2	243233.MCA1817	1.04e-31	115.0	COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,1S8VU@1236|Gammaproteobacteria,1XFF5@135618|Methylococcales	135618|Methylococcales	J	Belongs to the HSP15 family	hslR	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
k59_1409662_1	243159.AFE_1879	4.22e-35	134.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,2NCDI@225057|Acidithiobacillales	225057|Acidithiobacillales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_1057653_1	998088.B565_1626	6.68e-64	203.0	COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,1T1GE@1236|Gammaproteobacteria,1Y52X@135624|Aeromonadales	135624|Aeromonadales	P	membrane protein, TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
k59_529141_2	697282.Mettu_0485	6.52e-60	198.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,1XDYG@135618|Methylococcales	135618|Methylococcales	E	Aminotransferase, class I	-	-	2.6.1.17	ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1644664_2	340177.Cag_1662	4.19e-109	321.0	COG1028@1|root,COG1028@2|Bacteria,1FDUA@1090|Chlorobi	1090|Chlorobi	IQ	Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_60253_1	118797.XP_007446525.1	2.34e-68	220.0	COG0468@1|root,KOG1433@2759|Eukaryota,3AI1H@33154|Opisthokonta,3BXPE@33208|Metazoa,3DE5Z@33213|Bilateria	33208|Metazoa	L	Mitochondrial DNA repair protein recA homolog	-	-	-	-	-	-	-	-	-	-	-	-	RecA
k59_60253_2	1565129.JSFF01000002_gene3442	6.18e-08	55.5	COG1514@1|root,COG1514@2|Bacteria,1QEB6@1224|Proteobacteria,1TAWU@1236|Gammaproteobacteria,2QCHE@267890|Shewanellaceae	1236|Gammaproteobacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
k59_705344_1	68570.DC74_7418	5.01e-13	71.6	COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.53	ko:K00038	ko00140,ko01100,map00140,map01100	-	R04831,R04834,R04844,R04847	RC00139,RC01219,RC01220	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
k59_705344_2	675635.Psed_2069	5.32e-05	44.7	COG1024@1|root,COG1024@2|Bacteria,2H1U4@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_1821372_1	640512.BC1003_0664	1.63e-67	219.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VZNG@28216|Betaproteobacteria,1K6IW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	similarity to GP 3192745	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1152_1	1121405.dsmv_2856	1.15e-63	213.0	COG3039@1|root,COG3039@2|Bacteria,1PKUP@1224|Proteobacteria,43ECD@68525|delta/epsilon subdivisions,2X0BQ@28221|Deltaproteobacteria,2MP4F@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_470434_2	414684.RC1_3131	4.99e-147	433.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TQWP@28211|Alphaproteobacteria,2JQ0B@204441|Rhodospirillales	204441|Rhodospirillales	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1293030_1	1168034.FH5T_20555	2.6e-59	208.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,4NFTI@976|Bacteroidetes,2FNSJ@200643|Bacteroidia	976|Bacteroidetes	C	CoA binding domain protein	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1703271_1	644968.DFW101_2778	6.8e-26	112.0	COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,1RCHY@1224|Proteobacteria,42R1G@68525|delta/epsilon subdivisions,2WMR7@28221|Deltaproteobacteria,2M9WC@213115|Desulfovibrionales	28221|Deltaproteobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE
k59_1116273_1	743718.Isova_0826	2.92e-80	272.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GJD0@201174|Actinobacteria,4F3NY@85017|Promicromonosporaceae	201174|Actinobacteria	L	UvrD/REP helicase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,PDDEXK_1,UvrD-helicase,UvrD_C
k59_1468504_1	743719.PaelaDRAFT_3529	2.16e-66	214.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,4HA4E@91061|Bacilli,26QZ3@186822|Paenibacillaceae	91061|Bacilli	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_353775_1	2340.JV46_10670	4.61e-161	465.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,1T20U@1236|Gammaproteobacteria,1JAKX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Nickel-dependent hydrogenase	-	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
k59_764025_1	85643.Tmz1t_3172	2.68e-91	274.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2VHN6@28216|Betaproteobacteria,2KW8C@206389|Rhodocyclales	206389|Rhodocyclales	L	PFAM IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_1233700_1	1223542.GM1_066_00020	9.54e-40	141.0	COG2801@1|root,COG2801@2|Bacteria,2GKDY@201174|Actinobacteria,4GECQ@85026|Gordoniaceae	201174|Actinobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
k59_1233700_2	298653.Franean1_2613	2.87e-23	92.4	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_1468509_1	262968.Q5YFK8_9VIRU	1.18e-25	110.0	4QFET@10239|Viruses,4QY0D@35237|dsDNA viruses  no RNA stage	10239|Viruses	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1174975_1	1049564.TevJSym_ap00550	8.24e-34	125.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1J5UV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_1174975_2	937774.TEQUI_1050	5.37e-24	107.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,3T1EQ@506|Alcaligenaceae	28216|Betaproteobacteria	C	Catalyzes the transfer of electrons from NADH to ubiquinone	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1821402_1	1049564.TevJSym_ah00170	3.83e-114	340.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria,1J4WY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_646667_1	1121459.AQXE01000019_gene1898	1.28e-60	201.0	COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria,1MU3V@1224|Proteobacteria,42NRF@68525|delta/epsilon subdivisions,2WJZ6@28221|Deltaproteobacteria,2M8PV@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_411744_1	765912.Thimo_0110	9.66e-61	209.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1WWCN@135613|Chromatiales	135613|Chromatiales	S	Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
k59_764038_1	1122194.AUHU01000002_gene2848	2.54e-30	125.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,4645X@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_705373_1	1123368.AUIS01000011_gene1125	2.41e-36	140.0	COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,1RQGJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	type II and III secretion system protein	mshL	-	-	ko:K12282	-	-	-	-	ko00000,ko02044	-	-	-	STN,Secretin,Secretin_N_2
k59_1644699_1	1448139.AI20_18000	5.36e-07	57.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1Y478@135624|Aeromonadales	135624|Aeromonadales	D	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_646670_1	1194165.CAJF01000016_gene1326	9.6e-30	114.0	COG1609@1|root,COG1609@2|Bacteria,2GNVD@201174|Actinobacteria,4FMFK@85023|Microbacteriaceae	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
k59_646670_2	1122611.KB903985_gene3778	1.15e-39	140.0	COG0662@1|root,COG0662@2|Bacteria,2I83H@201174|Actinobacteria,4EJIE@85012|Streptosporangiales	201174|Actinobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_1195_1	1313172.YM304_09490	1.74e-95	310.0	COG1201@1|root,COG1201@2|Bacteria,2I6VR@201174|Actinobacteria,4CNBF@84992|Acidimicrobiia	84992|Acidimicrobiia	L	DEAD-like helicases superfamily	-	-	-	ko:K03724,ko:K06877	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C
k59_1821421_1	1267005.KB911258_gene555	4.6e-147	446.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2TQZU@28211|Alphaproteobacteria,3N6ID@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_60316_1	1121933.AUHH01000015_gene459	2.04e-22	88.2	2EM5W@1|root,335MU@2|Bacteria,2GVYV@201174|Actinobacteria	201174|Actinobacteria	S	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
k59_1591062_1	1166018.FAES_1856	4.1e-36	131.0	COG0270@1|root,COG0270@2|Bacteria,4P3WE@976|Bacteroidetes	976|Bacteroidetes	L	C-5 cytosine-specific DNA methylase	-	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
k59_476207_1	367299.JOEE01000001_gene1977	3e-113	333.0	COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria,4FE4C@85021|Intrasporangiaceae	201174|Actinobacteria	S	Coenzyme F420 biosynthesis-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
k59_949216_1	1487923.DP73_13630	2.91e-76	244.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2480U@186801|Clostridia,260QA@186807|Peptococcaceae	186801|Clostridia	H	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1121025_2	420662.Mpe_A1369	3.91e-102	307.0	COG2354@1|root,COG2354@2|Bacteria,1MVYU@1224|Proteobacteria,2VHTU@28216|Betaproteobacteria,1KJK3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF808)	yedI	-	-	ko:K09781	-	-	-	-	ko00000	-	-	-	DUF808
k59_828251_1	1713.JOFV01000012_gene784	1.01e-33	128.0	COG1073@1|root,COG1073@2|Bacteria,2I2KN@201174|Actinobacteria,4F25W@85016|Cellulomonadaceae	201174|Actinobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
k59_1356681_1	396588.Tgr7_0882	1.12e-69	224.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1WWHC@135613|Chromatiales	135613|Chromatiales	J	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
k59_1301435_1	313612.L8106_12370	2.37e-92	285.0	COG5361@1|root,COG5361@2|Bacteria,1G49Q@1117|Cyanobacteria,1H9SH@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_768762_1	1033806.HTIA_0923	1.76e-37	133.0	arCOG03965@1|root,arCOG03965@2157|Archaea,2Y30I@28890|Euryarchaeota,23Z5S@183963|Halobacteria	183963|Halobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_593627_1	472759.Nhal_3504	7.5e-80	252.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1WX73@135613|Chromatiales	135613|Chromatiales	M	PFAM Three-deoxy-D-manno-octulosonic-acid transferase	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N,Kdo
k59_1767247_2	590998.Celf_1154	7.15e-09	56.2	COG4420@1|root,COG4420@2|Bacteria,2GJRV@201174|Actinobacteria,4F2F3@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
k59_300218_1	765913.ThidrDRAFT_2406	2.6e-62	200.0	COG3677@1|root,COG3677@2|Bacteria,1NUTK@1224|Proteobacteria,1S11R@1236|Gammaproteobacteria,1WZ4K@135613|Chromatiales	135613|Chromatiales	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_535017_2	518766.Rmar_0453	2.95e-12	68.6	COG0210@1|root,COG0210@2|Bacteria,4NGP6@976|Bacteroidetes,1FITZ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1415789_1	1366050.N234_10135	5.95e-12	73.9	COG3497@1|root,COG3497@2|Bacteria,1MX89@1224|Proteobacteria,2VM4U@28216|Betaproteobacteria,1K9P6@119060|Burkholderiaceae	28216|Betaproteobacteria	S	COG Phage tail sheath protein FI	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
k59_949243_1	313612.L8106_11487	6.7e-24	106.0	COG0517@1|root,COG2202@1|root,COG2203@1|root,COG3920@1|root,COG0517@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3920@2|Bacteria,1GHCI@1117|Cyanobacteria,1H8J3@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,HATPase_c,HisKA_2,PAS,PAS_3,PAS_4,PAS_8,PAS_9
k59_1830861_1	1304865.JAGF01000001_gene1278	4.33e-38	150.0	COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,4F1P9@85016|Cellulomonadaceae	201174|Actinobacteria	KLT	PFAM Serine threonine-protein kinase-like domain	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_1830861_2	743718.Isova_0018	4.38e-56	180.0	COG0512@1|root,COG0512@2|Bacteria,2GJUX@201174|Actinobacteria,4F3HV@85017|Promicromonosporaceae	201174|Actinobacteria	EH	Peptidase C26	trpG	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_653394_2	1033802.SSPSH_001126	3.62e-40	135.0	COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,1SAAA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Rieske 2Fe-2S	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
k59_594482_1	880072.Desac_2562	8.7e-154	451.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WIX6@28221|Deltaproteobacteria,2MR22@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
k59_1357611_1	596154.Alide2_3597	3e-26	111.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,4AAIW@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM Phospholipase D Transphosphatidylase	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_769520_1	225937.HP15_58	1.56e-31	116.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,463YM@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	GTP cyclohydrolase I	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
k59_891521_1	765912.Thimo_2173	1.49e-55	187.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1WXEF@135613|Chromatiales	135613|Chromatiales	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_891521_2	1122212.AULO01000010_gene127	9e-130	376.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,1XHC4@135619|Oceanospirillales	135619|Oceanospirillales	G	catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis	fbaA	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
k59_1709680_1	930166.CD58_17715	4.25e-109	329.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Fad linked oxidase	glcD	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	iJN746.PP_3745,iLF82_1304.LF82_0831,iNRG857_1313.NRG857_14750	FAD-oxidase_C,FAD_binding_4
k59_477125_1	404380.Gbem_1031	9.9e-94	298.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2WJG7@28221|Deltaproteobacteria,43STK@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_1241544_1	1713.JOFV01000012_gene740	2.97e-81	253.0	COG1570@1|root,COG1570@2|Bacteria,2GJAS@201174|Actinobacteria,4F0DT@85016|Cellulomonadaceae	201174|Actinobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_1357613_1	340177.Cag_0616	6.06e-08	59.3	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Big_3_2,CHU_C,Flg_new,LRR_5
k59_653402_1	96561.Dole_1694	1.35e-97	303.0	COG0205@1|root,COG0205@2|Bacteria,1R560@1224|Proteobacteria,42P6N@68525|delta/epsilon subdivisions,2WINA@28221|Deltaproteobacteria,2MHN0@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Phosphofructokinase	pfp	-	2.7.1.11,2.7.1.90	ko:K00895,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_69840_1	880072.Desac_1929	8.41e-69	214.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,42VBM@68525|delta/epsilon subdivisions,2WSA4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_125067_1	1120948.KB903218_gene2088	9.84e-70	227.0	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,4DXII@85010|Pseudonocardiales	201174|Actinobacteria	C	TIGRFAM Dihydrolipoamide dehydrogenase	lpd	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
k59_125067_2	1121878.AUGL01000011_gene856	2.66e-73	233.0	COG0438@1|root,COG0438@2|Bacteria,1PDW1@1224|Proteobacteria,1RZIK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Capsular polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_1065900_1	28072.Nos7524_1286	1.93e-10	67.8	COG2931@1|root,COG3210@1|root,COG3291@1|root,COG3595@1|root,COG4070@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG3595@2|Bacteria,COG4070@2|Bacteria,1GHDQ@1117|Cyanobacteria,1HUA0@1161|Nostocales	1117|Cyanobacteria	Q	Domain of unknown function (DUF4114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114
k59_769527_1	497964.CfE428DRAFT_6300	1.84e-74	251.0	COG1216@1|root,COG3250@1|root,COG1216@2|Bacteria,COG3250@2|Bacteria,46SAC@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_72,Glycos_transf_2
k59_125068_2	554065.XP_005849108.1	8.08e-51	167.0	COG3542@1|root,2RM2D@2759|Eukaryota,37S4B@33090|Viridiplantae,34P9W@3041|Chlorophyta	3041|Chlorophyta	S	Cupin superfamily (DUF985)	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_5
k59_1121827_1	378806.STAUR_1777	1.05e-68	221.0	COG1446@1|root,COG1446@2|Bacteria,1MWFC@1224|Proteobacteria,42NRH@68525|delta/epsilon subdivisions,2WNIB@28221|Deltaproteobacteria,2YV7G@29|Myxococcales	28221|Deltaproteobacteria	E	Asparaginase	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
k59_69845_1	435908.IDSA_00305	2.58e-31	113.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,1S3Q7@1236|Gammaproteobacteria,2QG4T@267893|Idiomarinaceae	1236|Gammaproteobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
k59_69845_2	1248232.BANQ01000088_gene2636	9.18e-76	228.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria,1XSDR@135623|Vibrionales	135623|Vibrionales	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
k59_69845_3	545276.KB898735_gene1315	5.45e-49	157.0	COG3411@1|root,COG3411@2|Bacteria,1MZR4@1224|Proteobacteria,1S8U3@1236|Gammaproteobacteria,1WYUE@135613|Chromatiales	135613|Chromatiales	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
k59_363344_1	1167006.UWK_00367	4.57e-51	177.0	COG2905@1|root,COG2905@2|Bacteria,1R0B9@1224|Proteobacteria,43CTI@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K04739	ko04910,map04910	-	-	-	ko00000,ko00001	-	-	-	DUF4388,cNMP_binding
k59_829302_1	452637.Oter_1417	2.2e-30	122.0	COG0795@1|root,COG0795@2|Bacteria,46STR@74201|Verrucomicrobia,3K762@414999|Opitutae	414999|Opitutae	S	Predicted permease YjgP/YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_183804_1	555778.Hneap_1235	3.43e-12	66.2	COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,1RNUM@1236|Gammaproteobacteria,1WW3E@135613|Chromatiales	135613|Chromatiales	S	Deoxyribodipyrimidine photo-lyase-related protein	-	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP
k59_183804_2	1026882.MAMP_01198	1.75e-74	232.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria,462CA@72273|Thiotrichales	72273|Thiotrichales	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
k59_418281_1	748247.AZKH_3691	8.5e-84	256.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2VKZV@28216|Betaproteobacteria,2KVW9@206389|Rhodocyclales	206389|Rhodocyclales	S	Inhibitor of apoptosis-promoting Bax1	-	-	-	ko:K19416	-	M00742	-	-	ko00000,ko00002,ko02000	1.A.14.2.1	-	-	Bax1-I
k59_1065922_1	96561.Dole_2133	4.01e-82	256.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,42M9X@68525|delta/epsilon subdivisions,2WJ7E@28221|Deltaproteobacteria,2MIA5@213118|Desulfobacterales	28221|Deltaproteobacteria	L	AAA ATPase	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_1830896_1	1249627.D779_0578	1.89e-192	550.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1WX7K@135613|Chromatiales	135613|Chromatiales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1533575_2	604331.AUHY01000035_gene2448	3.8e-13	70.9	COG0664@1|root,COG0664@2|Bacteria,1WJXH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	COGs COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase	-	GO:0000166,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0017076,GO:0019219,GO:0019222,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0046983,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_712126_1	1487921.DP68_14725	1.02e-51	178.0	COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia,36GDB@31979|Clostridiaceae	186801|Clostridia	L	PFAM transposase, mutator	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_477145_1	1713.JOFV01000008_gene3216	1.43e-79	265.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2GJGR@201174|Actinobacteria,4F147@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM ComEC Rec2-related protein	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_69854_1	471853.Bcav_1120	1.65e-197	565.0	COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1241583_1	1121405.dsmv_0092	4.52e-27	114.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,42MFX@68525|delta/epsilon subdivisions,2WJ91@28221|Deltaproteobacteria,2MIXG@213118|Desulfobacterales	28221|Deltaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_1533578_1	177437.HRM2_20910	2.07e-89	272.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43BSG@68525|delta/epsilon subdivisions,2WM56@28221|Deltaproteobacteria,2MHKW@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
k59_1357636_1	78245.Xaut_1091	4.12e-38	148.0	COG1404@1|root,COG1404@2|Bacteria,1R5H7@1224|Proteobacteria,2UEP3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_1065936_1	1267535.KB906767_gene733	1.74e-58	198.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,3Y3TK@57723|Acidobacteria	57723|Acidobacteria	KOT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3,Response_reg
k59_245721_1	519989.ECTPHS_01769	2.24e-99	300.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1X0EW@135613|Chromatiales	135613|Chromatiales	O	Trypsin	-	-	-	ko:K04691	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
k59_1416861_1	1713.JOFV01000002_gene705	5.53e-48	166.0	COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria,4F2FU@85016|Cellulomonadaceae	201174|Actinobacteria	GM	ATPases associated with a variety of cellular activities	-	-	3.6.3.40	ko:K01990,ko:K09693	ko02010,map02010	M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.104	-	-	ABC_tran,Wzt_C
k59_1416861_2	1121952.ATXT01000015_gene240	2.28e-123	359.0	COG1682@1|root,COG1682@2|Bacteria,2GP5K@201174|Actinobacteria,4FNBV@85023|Microbacteriaceae	201174|Actinobacteria	GM	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_1121839_1	1095767.CAHD01000216_gene2682	3.49e-98	295.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_1065940_1	317025.Tcr_0057	2.86e-06	48.9	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,45ZMU@72273|Thiotrichales	72273|Thiotrichales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1065940_2	1117647.M5M_08255	6.11e-15	77.0	COG0845@1|root,COG0845@2|Bacteria,1R4JA@1224|Proteobacteria,1RPS5@1236|Gammaproteobacteria,1J60K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_891569_1	1123401.JHYQ01000029_gene1956	2.87e-59	191.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,4606Q@72273|Thiotrichales	72273|Thiotrichales	L	Exodeoxyribonuclease III xth	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_1533588_1	1043493.BBLU01000004_gene2724	9.72e-50	165.0	COG0637@1|root,COG0637@2|Bacteria,2I2IT@201174|Actinobacteria	201174|Actinobacteria	G	Beta-phosphoglucomutase family hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Hydrolase
k59_12045_1	744980.TRICHSKD4_0980	8.02e-89	271.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TSRF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	ET	COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain	aapJ	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K09969	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
k59_1709723_1	471853.Bcav_4032	2.67e-58	203.0	COG0392@1|root,COG0392@2|Bacteria,2GMAV@201174|Actinobacteria	201174|Actinobacteria	T	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
k59_1181869_1	713587.THITH_10965	4.75e-28	113.0	COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,1RPTU@1236|Gammaproteobacteria,1WXF3@135613|Chromatiales	135613|Chromatiales	I	Membrane protein involved in aromatic hydrocarbon degradation	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_1768126_1	177437.HRM2_27290	4.06e-51	170.0	COG2813@1|root,COG2813@2|Bacteria,1QWNH@1224|Proteobacteria,42TUN@68525|delta/epsilon subdivisions,2X74C@28221|Deltaproteobacteria,2MKFR@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_16
k59_1476646_1	566466.NOR53_1455	1.74e-88	280.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1J5D2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_12061_1	1123371.ATXH01000015_gene1654	2.42e-59	204.0	COG0369@1|root,COG1151@2|Bacteria,2GHI8@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Prismane/CO dehydrogenase family	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
k59_1241626_1	471853.Bcav_3966	1.44e-75	236.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_594533_1	1051632.TPY_0826	1.78e-05	52.4	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,3WCCU@538999|Clostridiales incertae sedis	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_477177_1	33898.JRHJ01000008_gene4671	6.86e-41	149.0	COG1653@1|root,COG1653@2|Bacteria,2I8TG@201174|Actinobacteria	201174|Actinobacteria	G	transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
k59_1357658_1	1187848.AJYQ01000008_gene535	7.37e-79	249.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,1RQ31@1236|Gammaproteobacteria,1XV2J@135623|Vibrionales	135623|Vibrionales	E	COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_1768134_1	941449.dsx2_3189	1.32e-79	242.0	COG2009@1|root,2ZBTX@2|Bacteria,1RB22@1224|Proteobacteria,42NAY@68525|delta/epsilon subdivisions,2WMPM@28221|Deltaproteobacteria,2M7WC@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM fumarate reductase respiratory complex	-	-	-	ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_1830951_1	172088.AUGA01000006_gene8000	2.27e-70	224.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2TSRZ@28211|Alphaproteobacteria,3JUE8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_1476652_1	497321.C664_12985	3.35e-42	141.0	COG0607@1|root,COG0607@2|Bacteria,1MZPW@1224|Proteobacteria,2VU52@28216|Betaproteobacteria,2KWZX@206389|Rhodocyclales	206389|Rhodocyclales	P	rhodanese-related sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1476652_2	768671.ThimaDRAFT_3045	4.73e-97	296.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1WX73@135613|Chromatiales	135613|Chromatiales	M	PFAM Three-deoxy-D-manno-octulosonic-acid transferase	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N,Kdo
k59_536006_1	1123514.KB905899_gene842	1.18e-166	491.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_653462_2	653386.HMPREF0975_02055	4.63e-53	176.0	COG1544@1|root,COG1544@2|Bacteria,2GMYF@201174|Actinobacteria,4D3AN@85005|Actinomycetales	201174|Actinobacteria	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
k59_183856_1	572477.Alvin_0107	1.14e-21	89.7	2B7TJ@1|root,32102@2|Bacteria,1RHKS@1224|Proteobacteria,1S7PY@1236|Gammaproteobacteria,1WYNN@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF5063)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5063
k59_183856_2	2340.JV46_15990	1.37e-52	168.0	COG0316@1|root,COG0316@2|Bacteria,1RFIX@1224|Proteobacteria,1S3SB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the HesB IscA family	-	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
k59_477185_1	96561.Dole_0715	2.43e-64	199.0	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,42QW5@68525|delta/epsilon subdivisions,2WP71@28221|Deltaproteobacteria,2MJKH@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
k59_477185_2	888727.HMPREF9092_0696	7.51e-14	66.2	COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,24QV1@186801|Clostridia,3WCNW@538999|Clostridiales incertae sedis	186801|Clostridia	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
k59_1357666_1	314287.GB2207_05427	8.03e-93	290.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1J5CM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1066005_1	68223.JNZY01000010_gene1897	3.59e-97	302.0	COG4320@1|root,COG4320@2|Bacteria,2GKEK@201174|Actinobacteria	201174|Actinobacteria	K	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
k59_125124_1	926550.CLDAP_29440	1.91e-37	129.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	lsrG	-	5.3.1.32	ko:K11530	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	ABM
k59_125124_2	573370.DMR_27750	8e-07	52.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,42NP2@68525|delta/epsilon subdivisions,2WIY2@28221|Deltaproteobacteria,2M8N5@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
k59_1363820_1	765911.Thivi_3821	2.43e-148	428.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,1RNGN@1236|Gammaproteobacteria,1WXFQ@135613|Chromatiales	135613|Chromatiales	G	PFAM Glucose Sorbosone dehydrogenase	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	GSDH
k59_1076074_1	999141.GME_16062	1.52e-35	127.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,1XH4S@135619|Oceanospirillales	135619|Oceanospirillales	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_23
k59_1076074_2	59538.XP_005976936.1	1.85e-06	52.4	COG0147@1|root,KOG1223@2759|Eukaryota,38FJ5@33154|Opisthokonta	33154|Opisthokonta	E	anthranilate synthase activity	TRP2	GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_1009692_2	78345.BMERY_0944	5.25e-32	117.0	COG1917@1|root,COG1917@2|Bacteria,2IHSV@201174|Actinobacteria,4D0ZF@85004|Bifidobacteriales	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_1076076_1	1267005.KB911265_gene3631	3.37e-81	265.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2TR7V@28211|Alphaproteobacteria,3N6HF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DEAD/H associated	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_542189_1	1353537.TP2_00600	2.49e-82	263.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,2XM2W@285107|Thioclava	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	-	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SecA_DEAD,SecA_PP_bind
k59_900407_2	582744.Msip34_0288	1.03e-17	78.6	COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,2VUPV@28216|Betaproteobacteria,2KN3Q@206350|Nitrosomonadales	206350|Nitrosomonadales	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
k59_424627_1	585531.HMPREF0063_10697	8.54e-60	194.0	COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,4DQ8M@85009|Propionibacteriales	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA2	GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_835823_2	1049564.TevJSym_af00190	2.49e-70	216.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,1S60Z@1236|Gammaproteobacteria,1J698@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	GO:0002097,GO:0002100,GO:0003674,GO:0003824,GO:0004000,GO:0005488,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008251,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0052717,GO:0071704,GO:0090304,GO:1901360	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
k59_900416_1	768671.ThimaDRAFT_2228	3.35e-09	56.2	COG3665@1|root,COG3665@2|Bacteria,1N9DM@1224|Proteobacteria,1RR1E@1236|Gammaproteobacteria,1WW97@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM Urea carboxylase-associated protein 1	-	-	-	ko:K09967	-	-	-	-	ko00000	-	-	-	DUF1989
k59_900416_2	768671.ThimaDRAFT_2227	1.14e-97	289.0	COG3665@1|root,COG3665@2|Bacteria,1N2KR@1224|Proteobacteria,1RN5H@1236|Gammaproteobacteria,1WY7K@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM Urea carboxylase-associated protein 2	-	-	-	ko:K09967	-	-	-	-	ko00000	-	-	-	DUF1989
k59_1311585_2	1232410.KI421417_gene2727	2.5e-22	101.0	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,42N9J@68525|delta/epsilon subdivisions,2X2B8@28221|Deltaproteobacteria,43U8G@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	-	-	-	-	-	-	-	-	-	Toluene_X
k59_1539803_1	1453496.AT03_09880	3.99e-19	92.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	fadD	GO:0001676,GO:0003674,GO:0003824,GO:0004467,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006635,GO:0006637,GO:0006644,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009898,GO:0009987,GO:0015645,GO:0016020,GO:0016042,GO:0016054,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019395,GO:0019637,GO:0019693,GO:0019752,GO:0030258,GO:0031406,GO:0032787,GO:0033293,GO:0033865,GO:0033875,GO:0034032,GO:0034440,GO:0034641,GO:0035383,GO:0036041,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046395,GO:0046483,GO:0050896,GO:0051186,GO:0055086,GO:0055114,GO:0070538,GO:0071704,GO:0071944,GO:0072329,GO:0072521,GO:0090407,GO:0098552,GO:0098562,GO:1901135,GO:1901360,GO:1901564,GO:1901575,GO:1901576	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	iSF_1195.SF1423,iSFxv_1172.SFxv_1611,iS_1188.S1538	AMP-binding,AMP-binding_C
k59_190424_1	1158146.KB907125_gene2383	2.75e-43	161.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1WVV2@135613|Chromatiales	135613|Chromatiales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_1715751_1	438753.AZC_1033	1.68e-48	155.0	2AMHV@1|root,31CDG@2|Bacteria,1RGVA@1224|Proteobacteria,2U98Q@28211|Alphaproteobacteria,3EZQE@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1153)	MA20_11245	-	-	-	-	-	-	-	-	-	-	-	DUF1153
k59_1658320_1	1144325.PMI22_00727	1.39e-28	115.0	COG2365@1|root,COG2365@2|Bacteria,1R4XF@1224|Proteobacteria,1RMPM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Protein tyrosine serine phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Y_phosphatase3
k59_1188522_1	118166.JH976537_gene4704	8.27e-79	260.0	COG0474@1|root,COG0474@2|Bacteria,1G2C4@1117|Cyanobacteria,1HE7Y@1150|Oscillatoriales	1117|Cyanobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_22917_1	765913.ThidrDRAFT_2649	1.02e-19	89.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1WWAE@135613|Chromatiales	135613|Chromatiales	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_22917_2	876044.IMCC3088_1541	7.27e-27	100.0	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,1S9AI@1236|Gammaproteobacteria,1J6U6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
k59_22917_3	768671.ThimaDRAFT_4605	1.79e-17	77.4	COG0662@1|root,COG0662@2|Bacteria,1QUHG@1224|Proteobacteria,1T1Z6@1236|Gammaproteobacteria,1WZ1B@135613|Chromatiales	135613|Chromatiales	G	PFAM Cupin 2, conserved barrel	-	-	-	ko:K11312	-	-	-	-	ko00000	-	-	-	Cupin_2
k59_424642_1	864051.BurJ1DRAFT_3045	2.13e-09	58.2	COG1229@1|root,COG1229@2|Bacteria,1NX13@1224|Proteobacteria,2VK99@28216|Betaproteobacteria,1KJGV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Amidohydrolase family	fhcA	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
k59_424642_2	717785.HYPMC_1889	1.44e-33	127.0	COG1029@1|root,COG1029@2|Bacteria,1R64R@1224|Proteobacteria,2TVI1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Formylmethanofuran dehydrogenase, subunit B	-	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	-
k59_1485600_1	1123257.AUFV01000008_gene745	1.99e-09	59.7	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,1RPGT@1236|Gammaproteobacteria,1X5HI@135614|Xanthomonadales	135614|Xanthomonadales	I	Acetyl-coenzyme A synthetase N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ACAS_N,AMP-binding
k59_1485600_2	335283.Neut_0977	3.45e-66	207.0	28Z54@1|root,2ZKXF@2|Bacteria,1RAVB@1224|Proteobacteria,2WCWZ@28216|Betaproteobacteria,373XF@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1658324_1	1408322.JHYK01000009_gene2319	1.95e-17	84.3	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,27JRU@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_1658324_2	1410622.JNKY01000018_gene674	2.87e-14	70.1	COG0359@1|root,COG0359@2|Bacteria,1V6QG@1239|Firmicutes,24MT6@186801|Clostridia,27N8W@186928|unclassified Lachnospiraceae	186801|Clostridia	J	binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
k59_718695_1	472759.Nhal_2574	2.04e-129	377.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,1RZ45@1236|Gammaproteobacteria,1WWNT@135613|Chromatiales	135613|Chromatiales	S	Metallophosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
k59_718695_2	107636.JQNK01000009_gene2679	1.33e-27	108.0	COG0575@1|root,COG0575@2|Bacteria,1N4I3@1224|Proteobacteria,2U7WC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	CDP-archaeol synthase	-	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
k59_600477_1	697282.Mettu_0395	2.44e-92	285.0	COG5520@1|root,COG5520@2|Bacteria,1N9T9@1224|Proteobacteria,1RP92@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 30 family	-	-	3.2.1.45	ko:K01201	ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH30	-	Glyco_hydro_30,Glyco_hydro_30C
k59_600477_2	768671.ThimaDRAFT_4559	4.01e-73	237.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WXWA@135613|Chromatiales	135613|Chromatiales	U	sulphate transporter	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
k59_1009720_1	880072.Desac_2227	1.15e-34	125.0	COG2259@1|root,COG2259@2|Bacteria,1NC5I@1224|Proteobacteria,42V27@68525|delta/epsilon subdivisions,2WS2G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Methylamine	-	-	-	-	-	-	-	-	-	-	-	-	MauE
k59_1839794_1	519989.ECTPHS_01379	3.82e-76	238.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1WWFQ@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
k59_959428_1	266940.Krad_0242	1.12e-20	97.1	COG3119@1|root,COG3119@2|Bacteria,2H59R@201174|Actinobacteria	201174|Actinobacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1311612_1	1127673.GLIP_1996	2.21e-52	186.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D9@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	mdtB	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_1423522_1	367299.JOEE01000001_gene2029	1.27e-47	166.0	COG1333@1|root,COG1333@2|Bacteria,2GMGH@201174|Actinobacteria,4FE3H@85021|Intrasporangiaceae	201174|Actinobacteria	O	cytochrome C	-	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
k59_1423522_2	367299.JOEE01000001_gene2028	2e-95	284.0	COG0785@1|root,COG0785@2|Bacteria,2GJW3@201174|Actinobacteria,4FF34@85021|Intrasporangiaceae	201174|Actinobacteria	O	cytochrome c biogenesis protein	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
k59_256513_2	1121861.KB899918_gene3300	4.67e-27	105.0	COG0695@1|root,COG0695@2|Bacteria,1R2GN@1224|Proteobacteria,2TZK6@28211|Alphaproteobacteria,2JZ32@204441|Rhodospirillales	204441|Rhodospirillales	O	Protein of unknown function (DUF3429)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3429
k59_1009724_1	1158050.KB895454_gene1529	1.2e-45	152.0	COG0071@1|root,COG0071@2|Bacteria,2GQGQ@201174|Actinobacteria,1WBR0@1268|Micrococcaceae	201174|Actinobacteria	O	Belongs to the small heat shock protein (HSP20) family	hspX	GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016310,GO:0019538,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0036294,GO:0040007,GO:0040008,GO:0042221,GO:0042594,GO:0043170,GO:0043207,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045926,GO:0046777,GO:0048519,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0065007,GO:0070482,GO:0070887,GO:0071453,GO:0071456,GO:0071496,GO:0071704,GO:0071944,GO:0075136,GO:1901564	-	-	-	-	-	-	-	-	-	-	HSP20
k59_131821_1	2340.JV46_04470	1.05e-05	47.4	COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria,1J7D0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07673	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3
k59_131821_2	2340.JV46_03880	4.47e-57	184.0	COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,1RNXI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	response regulator	-	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_1839804_1	1049564.TevJSym_ah00950	4.36e-76	248.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1J54K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdZ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_835848_1	749222.Nitsa_0627	1.05e-44	151.0	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,42MJU@68525|delta/epsilon subdivisions,2YM7H@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iIT341.HP0646	NTP_transferase
k59_835848_2	1049564.TevJSym_ab00900	1.22e-73	222.0	COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,1S343@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Pfam Rhodanese-like	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_78607_2	768671.ThimaDRAFT_2445	4.7e-67	230.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales	135613|Chromatiales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1188539_1	187272.Mlg_1440	3.76e-78	245.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1WW0V@135613|Chromatiales	135613|Chromatiales	M	lipoprotein releasing system, transmembrane protein, LolC E family	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_1188539_2	1123261.AXDW01000001_gene1445	2.17e-94	283.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1X2X9@135614|Xanthomonadales	135614|Xanthomonadales	V	Part of the ABC transporter complex LolCDE involved in the translocation of	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
k59_900459_1	908612.HMPREF9720_1785	2.36e-30	120.0	COG0611@1|root,COG0611@2|Bacteria,4P05Y@976|Bacteroidetes,2FX67@200643|Bacteroidia,22UA9@171550|Rikenellaceae	976|Bacteroidetes	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	-	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_1076147_1	765913.ThidrDRAFT_0423	7.73e-69	230.0	COG2885@1|root,COG3267@1|root,COG2885@2|Bacteria,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1WXX2@135613|Chromatiales	135613|Chromatiales	U	SMART AAA ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,OmpA
k59_1659547_1	395493.BegalDRAFT_0512	3.72e-07	49.3	COG2863@1|root,COG2863@2|Bacteria	2|Bacteria	C	cytochrome	-	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K17230	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_1659547_2	331678.Cphamn1_0010	2.82e-32	124.0	COG0446@1|root,COG0446@2|Bacteria,1FDM3@1090|Chlorobi	1090|Chlorobi	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.2.3	ko:K17229	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2
k59_24260_1	187272.Mlg_1104	2.04e-09	57.8	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,1T2DW@1236|Gammaproteobacteria,1X2PB@135613|Chromatiales	135613|Chromatiales	EQ	PFAM Hydantoinase B oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_24260_2	1123514.KB905899_gene1880	7.65e-73	226.0	COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,1S8F8@1236|Gammaproteobacteria,4638B@72273|Thiotrichales	72273|Thiotrichales	S	Urate oxidase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
k59_1313339_1	768671.ThimaDRAFT_1715	4.62e-132	379.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,1WWC1@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM FeS assembly ATPase SufC	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
k59_1128410_1	290397.Adeh_3592	2.43e-34	129.0	2DKHM@1|root,309GY@2|Bacteria,1RFJ6@1224|Proteobacteria,43BG3@68525|delta/epsilon subdivisions,2X6UE@28221|Deltaproteobacteria,2Z3CV@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1541036_1	1267005.KB911259_gene3886	1.49e-32	117.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,2U70Z@28211|Alphaproteobacteria,3N6RG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
k59_1541036_2	1267005.KB911259_gene3885	1e-95	284.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2TSKM@28211|Alphaproteobacteria,3N6TD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
k59_1077767_1	795666.MW7_1387	1.2e-122	369.0	COG1055@1|root,COG1055@2|Bacteria,1MXKG@1224|Proteobacteria,2VI3Y@28216|Betaproteobacteria,1K04Q@119060|Burkholderiaceae	28216|Betaproteobacteria	P	antiporter	arsB	-	-	-	-	-	-	-	-	-	-	-	CitMHS_2
k59_373936_1	367299.JOEE01000002_gene2289	2.9e-129	376.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4FFAU@85021|Intrasporangiaceae	201174|Actinobacteria	E	in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor	aspC	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.6.1.1,2.6.1.2,2.6.1.66	ko:K00812,ko:K14260	ko00220,ko00250,ko00270,ko00290,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00258,R00355,R00694,R00734,R00896,R01215,R02433,R02619,R05052	RC00006,RC00008,RC00036	ko00000,ko00001,ko01000,ko01007	-	-	iNJ661.Rv0337c	Aminotran_1_2
k59_1365111_1	2340.JV46_18250	2.48e-107	327.0	COG1109@1|root,COG1109@2|Bacteria,1MUB3@1224|Proteobacteria,1RNFZ@1236|Gammaproteobacteria,1J9DB@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	manB	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_961170_1	1499967.BAYZ01000101_gene3614	2.28e-68	219.0	COG0366@1|root,COG0366@2|Bacteria,2NREA@2323|unclassified Bacteria	2|Bacteria	G	Glycosyl hydrolase family 70	amyS	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,CBM_20,DUF1939
k59_373949_1	324602.Caur_2136	1.1e-34	136.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,2G6C1@200795|Chloroflexi,376FK@32061|Chloroflexia	32061|Chloroflexia	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
k59_1077782_1	356829.BITS_0443	1.28e-73	234.0	COG0330@1|root,COG0330@2|Bacteria,2GM0Z@201174|Actinobacteria,4D1Z1@85004|Bifidobacteriales	201174|Actinobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_601685_1	1267005.KB911260_gene3542	4.15e-159	454.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2TR87@28211|Alphaproteobacteria,3N633@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k59_1010702_1	1283300.ATXB01000001_gene798	4.56e-115	338.0	COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,1RNAA@1236|Gammaproteobacteria,1XDTD@135618|Methylococcales	135618|Methylococcales	IQ	short-chain dehydrogenase reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1775481_2	768671.ThimaDRAFT_1574	3.69e-216	609.0	COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,1RPGZ@1236|Gammaproteobacteria,1WWD2@135613|Chromatiales	135613|Chromatiales	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
k59_543399_1	1195246.AGRI_14580	2.85e-79	255.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,46499@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG0608 Single-stranded DNA-specific exonuclease	recJ	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_1077794_1	935839.JAGJ01000007_gene3244	3.42e-150	454.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2GMFD@201174|Actinobacteria,4F3GF@85017|Promicromonosporaceae	201174|Actinobacteria	J	B3/4 domain	pheT	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_258008_1	948106.AWZT01000002_gene6452	2.8e-24	102.0	COG2207@1|root,COG2207@2|Bacteria,1R4MG@1224|Proteobacteria,2VIP9@28216|Betaproteobacteria,1K6QW@119060|Burkholderiaceae	28216|Betaproteobacteria	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_258008_2	1121935.AQXX01000116_gene5166	4.63e-15	74.7	COG3320@1|root,COG4221@1|root,COG3320@2|Bacteria,COG4221@2|Bacteria,1QSHC@1224|Proteobacteria,1RQP8@1236|Gammaproteobacteria,1XMDW@135619|Oceanospirillales	135619|Oceanospirillales	M	dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4,adh_short
k59_1252032_1	998674.ATTE01000001_gene2458	1.79e-96	289.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,460P6@72273|Thiotrichales	72273|Thiotrichales	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	cyoE	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_1717028_2	1906.SFRA_22205	2.06e-10	70.9	COG4995@1|root,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,NB-ARC,SIR2_2
k59_902242_1	378806.STAUR_5870	4.25e-05	45.8	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,42N8G@68525|delta/epsilon subdivisions,2WKBC@28221|Deltaproteobacteria,2YXKR@29|Myxococcales	28221|Deltaproteobacteria	E	Amino acid kinase family	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_902242_2	583355.Caka_3035	2.67e-60	208.0	COG0165@1|root,COG0165@2|Bacteria,46SCX@74201|Verrucomicrobia,3KA2P@414999|Opitutae	414999|Opitutae	E	Argininosuccinate lyase C-terminal	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_133006_1	716541.ECL_00802	2.87e-36	133.0	COG0604@1|root,COG0604@2|Bacteria,1MU4N@1224|Proteobacteria,1RNSV@1236|Gammaproteobacteria,3X02B@547|Enterobacter	1236|Gammaproteobacteria	C	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
k59_1487035_2	760117.JN27_18505	3.24e-93	301.0	COG4249@1|root,COG4249@2|Bacteria,1MYPK@1224|Proteobacteria	1224|Proteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
k59_1313395_1	1121481.AUAS01000004_gene1592	1.33e-13	74.3	COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,4NDV1@976|Bacteroidetes,47JGM@768503|Cytophagia	976|Bacteroidetes	G	COGs COG2133 Glucose sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,GSDH
k59_1313395_2	1322246.BN4_10816	8.99e-21	89.7	COG2045@1|root,COG2045@2|Bacteria,1N3KG@1224|Proteobacteria,431UT@68525|delta/epsilon subdivisions,2WWVQ@28221|Deltaproteobacteria,2MAMW@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Belongs to the ComB family	-	-	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
k59_1189750_2	2340.JV46_18900	2.62e-72	219.0	COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,1S343@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Pfam Rhodanese-like	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1128443_1	768671.ThimaDRAFT_2269	3.8e-135	395.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1WWVW@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM cytochrome c oxidase accessory protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
k59_1487036_1	765912.Thimo_1916	2.23e-86	277.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WWIV@135613|Chromatiales	135613|Chromatiales	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_601700_2	862965.PARA_01650	2.94e-84	261.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1Y7SN@135625|Pasteurellales	135625|Pasteurellales	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
k59_1321552_2	314345.SPV1_03478	1.51e-47	160.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria	1224|Proteobacteria	Q	Methyltransferase type 11	arsM	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_31
k59_1015601_1	686340.Metal_3700	4.4e-37	141.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,1XE14@135618|Methylococcales	135618|Methylococcales	M	Sporulation related domain	-	-	-	ko:K16291	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	LysM,SPOR,YkuD
k59_548904_1	264732.Moth_0081	3.32e-94	309.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,42EQJ@68295|Thermoanaerobacterales	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1085227_1	1049564.TevJSym_bg00290	1.56e-134	385.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,1RN7C@1236|Gammaproteobacteria,1J7ZN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	CbbQ/NirQ/NorQ C-terminal	nirQ	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
k59_1085227_2	2340.JV46_05480	2.46e-43	146.0	2C0CP@1|root,32SP5@2|Bacteria,1N5DU@1224|Proteobacteria,1SJ9A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1085227_3	2340.JV46_05470	1.02e-144	417.0	COG0348@1|root,COG0348@2|Bacteria,1MUWD@1224|Proteobacteria,1RZ0Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
k59_1085227_4	1121935.AQXX01000124_gene59	1.78e-23	105.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,1XHRA@135619|Oceanospirillales	135619|Oceanospirillales	P	von Willebrand factor (vWF) type A domain	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA
k59_1781278_1	261292.Nit79A3_2722	7.69e-41	145.0	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,2WGXF@28216|Betaproteobacteria,372AF@32003|Nitrosomonadales	28216|Betaproteobacteria	M	PFAM Peptidase M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_197205_1	375451.RD1_0845	2.03e-75	240.0	COG0189@1|root,COG0189@2|Bacteria,1QZG1@1224|Proteobacteria	1224|Proteobacteria	HJ	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1493925_1	1163617.SCD_n00545	1.12e-48	162.0	2BKU0@1|root,32FA8@2|Bacteria,1RJX5@1224|Proteobacteria,2W2XB@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_33540_1	251221.35212579	4e-73	235.0	COG0439@1|root,COG0439@2|Bacteria,1G1M0@1117|Cyanobacteria	1117|Cyanobacteria	I	acetyl-CoA carboxylase, biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_1723671_2	1380354.JIAN01000008_gene3518	3.14e-130	378.0	COG0672@1|root,COG0672@2|Bacteria,2GJ22@201174|Actinobacteria	201174|Actinobacteria	P	Iron permease FTR1	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1,Peptidase_M75
k59_1196403_1	1122223.KB890687_gene2601	1.89e-33	126.0	COG2267@1|root,COG2267@2|Bacteria,1WNIJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1547450_1	1347342.BN863_33650	7.17e-46	161.0	COG0615@1|root,COG2605@1|root,COG0615@2|Bacteria,COG2605@2|Bacteria,4NGSD@976|Bacteroidetes	976|Bacteroidetes	IM	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,GHMP_kinases_C
k59_1723674_1	926564.KI911627_gene3196	2.82e-14	71.6	COG1175@1|root,COG1175@2|Bacteria,2GKJI@201174|Actinobacteria,4F53W@85017|Promicromonosporaceae	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_1723674_2	479431.Namu_1774	1.94e-68	217.0	COG0395@1|root,COG0395@2|Bacteria,2GK1V@201174|Actinobacteria,4ERSQ@85013|Frankiales	201174|Actinobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	cebG	-	-	ko:K02026,ko:K05815,ko:K10190,ko:K10242,ko:K17236	ko02010,map02010	M00198,M00199,M00206,M00207,M00602	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.23,3.A.1.1.3,3.A.1.1.34,3.A.1.1.4	-	-	BPD_transp_1
k59_911691_1	1396141.BATP01000039_gene1381	7.44e-94	307.0	COG4630@1|root,COG4631@1|root,COG4630@2|Bacteria,COG4631@2|Bacteria,46Z71@74201|Verrucomicrobia,2IWQ8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	F	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_843626_1	414684.RC1_0754	6.65e-65	211.0	COG1409@1|root,COG1409@2|Bacteria,1MXD6@1224|Proteobacteria,2TSJ4@28211|Alphaproteobacteria,2JSIK@204441|Rhodospirillales	204441|Rhodospirillales	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_1547455_1	1224318.DT73_17330	1.67e-86	263.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_1547455_2	243233.MCA1222	1.07e-36	131.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,1XEQU@135618|Methylococcales	135618|Methylococcales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
k59_1371539_1	1458357.BG58_33490	9.15e-50	171.0	COG2267@1|root,COG2267@2|Bacteria,1QU7K@1224|Proteobacteria,2WH63@28216|Betaproteobacteria,1KII6@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_35133_1	1288826.MSNKSG1_04236	1.04e-91	293.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,464UX@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG0474 Cation transport ATPase	-	-	3.6.3.6	ko:K01535,ko:K12955	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.24,3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_432333_1	1232437.KL662031_gene2542	5.74e-84	261.0	COG3202@1|root,COG3202@2|Bacteria,1RCHN@1224|Proteobacteria	1224|Proteobacteria	P	Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism	tlc4	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015931,GO:0016020,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	TLC
k59_383448_1	580332.Slit_1987	2.79e-26	109.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2VK2D@28216|Betaproteobacteria,44V6Z@713636|Nitrosomonadales	28216|Betaproteobacteria	S	PFAM glycine cleavage T protein (aminomethyl transferase)	ygfZ	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
k59_1495047_1	312284.A20C1_04131	3.63e-30	110.0	COG0537@1|root,COG0537@2|Bacteria,2IHPT@201174|Actinobacteria,3UWUX@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	FG	Scavenger mRNA decapping enzyme C-term binding	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	DcpS_C,HIT
k59_1260613_1	269799.Gmet_1168	3.96e-26	109.0	COG1624@1|root,COG1624@2|Bacteria,1PEQT@1224|Proteobacteria,42P5A@68525|delta/epsilon subdivisions,2WKPP@28221|Deltaproteobacteria,43UIQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	-	-	-	-	-	-	-	-	-	-	DisA_N,YbbR
k59_911724_1	1049564.TevJSym_ac00800	4.86e-139	407.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1J5J8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	fleQ	-	-	ko:K10941	ko02020,ko02025,ko05111,map02020,map02025,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	FleQ,HTH_8,Sigma54_activat
k59_1666318_1	765910.MARPU_14045	1.35e-44	164.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,1WWRZ@135613|Chromatiales	135613|Chromatiales	M	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k59_315315_1	439235.Dalk_1463	1.69e-90	275.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1RJT0@1224|Proteobacteria,43CRQ@68525|delta/epsilon subdivisions,2X7ZB@28221|Deltaproteobacteria,2MPB2@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_315318_2	1120954.ATXE01000001_gene1613	1.1e-16	77.0	COG1595@1|root,COG1595@2|Bacteria,2GP9D@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
k59_911742_1	1565129.JSFF01000013_gene318	2.95e-07	50.8	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,2Q9MX@267890|Shewanellaceae	1236|Gammaproteobacteria	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_911742_2	1168065.DOK_18230	6.74e-64	204.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1J5D3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_3165,iECOK1_1307.ECOK1_3701,iECS88_1305.ECS88_3669,iECUMN_1333.ECUMN_3755,iSBO_1134.SBO_3275,iUMN146_1321.UM146_16315,iUTI89_1310.UTI89_C3726	Shikimate_DH,Shikimate_dh_N
k59_1086380_1	391008.Smal_3978	1.57e-61	215.0	COG0591@1|root,COG0642@1|root,COG0745@1|root,COG0591@2|Bacteria,COG0745@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,1X43U@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
k59_268795_1	743720.Psefu_2885	3.07e-93	281.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,1RMAE@1236|Gammaproteobacteria,1YXAI@136845|Pseudomonas putida group	1236|Gammaproteobacteria	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008690,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019294,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046394,GO:0046400,GO:0046401,GO:0046872,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF1260.b0918,iB21_1397.B21_00929,iBWG_1329.BWG_0770,iECBD_1354.ECBD_2677,iECB_1328.ECB_00922,iECDH10B_1368.ECDH10B_0988,iECDH1ME8569_1439.ECDH1ME8569_0869,iECD_1391.ECD_00922,iETEC_1333.ETEC_0986,iEcDH1_1363.EcDH1_2725,iEcHS_1320.EcHS_A1025,iEcolC_1368.EcolC_2678,iJO1366.b0918,iJR904.b0918,iPC815.YPO1400,iUMNK88_1353.UMNK88_1071,iY75_1357.Y75_RS04770	CTP_transf_3
k59_1134679_1	1117647.M5M_10930	1.29e-64	212.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1J5MU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Pyruvate kinase, barrel domain	pykF	GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	iECO103_1326.ECO103_1819,iPC815.YPO2393	PK,PK_C
k59_491172_1	755178.Cyan10605_2386	1.61e-18	87.4	COG3900@1|root,COG3900@2|Bacteria,1G5FF@1117|Cyanobacteria	1117|Cyanobacteria	S	periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
k59_1666343_1	1129794.C427_0212	1.4e-75	243.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,1RQK5@1236|Gammaproteobacteria,464XB@72275|Alteromonadaceae	1236|Gammaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_608433_1	1123371.ATXH01000001_gene1284	2.12e-51	182.0	COG3005@1|root,COG3005@2|Bacteria,2GHZU@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
k59_911761_1	471853.Bcav_2890	2.17e-116	350.0	COG5282@1|root,COG5282@2|Bacteria,2GJ9K@201174|Actinobacteria	201174|Actinobacteria	H	hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
k59_1547498_1	880073.Calab_2683	3.12e-55	189.0	COG1007@1|root,COG1007@2|Bacteria,2NNMY@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_268815_1	1307759.JOMJ01000003_gene1644	0.000857	42.4	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,42NYT@68525|delta/epsilon subdivisions,2WIM3@28221|Deltaproteobacteria,2M8SY@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_268815_2	314278.NB231_16478	9.73e-50	176.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria,1WX35@135613|Chromatiales	135613|Chromatiales	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_1260654_1	1209072.ALBT01000007_gene2820	2.64e-79	258.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1FH14@10|Cellvibrio	1236|Gammaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_4,DNA_pol3_tau_5
k59_843672_1	1385519.N801_11590	1.91e-106	314.0	COG2321@1|root,COG2321@2|Bacteria,2H3UT@201174|Actinobacteria,4FFIT@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative neutral zinc metallopeptidase	ypfJ	GO:0005575,GO:0005576	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
k59_1851246_1	5334.XP_003036799.1	1.94e-22	100.0	COG1574@1|root,2QSHE@2759|Eukaryota,390UK@33154|Opisthokonta,3NXIW@4751|Fungi,3UZCZ@5204|Basidiomycota,226ID@155619|Agaricomycetes,3W4HV@5338|Agaricales	4751|Fungi	G	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_970810_1	666685.R2APBS1_0971	2.89e-106	340.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1X3ME@135614|Xanthomonadales	135614|Xanthomonadales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_970810_2	998674.ATTE01000001_gene4273	3.77e-46	152.0	COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,1S5V7@1236|Gammaproteobacteria,460RJ@72273|Thiotrichales	72273|Thiotrichales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
k59_1260657_1	1249627.D779_0083	1.52e-92	281.0	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,1RQBE@1236|Gammaproteobacteria,1WX20@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
k59_268826_1	521674.Plim_3689	6.43e-06	48.5	COG0339@1|root,COG0339@2|Bacteria,2J2A5@203682|Planctomycetes	203682|Planctomycetes	E	Peptidase family M3	-	-	3.4.15.5,3.4.24.70	ko:K01284,ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_268826_2	545276.KB898729_gene1627	1.75e-74	231.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1WWV1@135613|Chromatiales	135613|Chromatiales	L	PFAM Endonuclease Exonuclease phosphatase	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_1260658_1	330214.NIDE2979	6.19e-70	228.0	COG0265@1|root,COG0265@2|Bacteria,3J0X9@40117|Nitrospirae	2|Bacteria	M	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	htrA	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
k59_89979_1	670307.HYPDE_23763	6.67e-68	216.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2TREC@28211|Alphaproteobacteria,3N6C3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	1.3.1.98,6.3.2.4	ko:K00075,ko:K01921	ko00473,ko00520,ko00550,ko01100,ko01502,map00473,map00520,map00550,map01100,map01502	-	R01150,R03191,R03192	RC00064,RC00141,RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_491189_1	717785.HYPMC_0336	2.14e-79	248.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2TSEY@28211|Alphaproteobacteria,3N6CM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_383515_1	744980.TRICHSKD4_6203	4.96e-28	116.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	bioA	-	2.6.1.113	ko:K12256	ko00330,ko01100,map00330,map01100	-	R08714	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_268832_1	648757.Rvan_1166	7.5e-59	186.0	COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,2TV7J@28211|Alphaproteobacteria,3N6R6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
k59_608448_1	177437.HRM2_02770	6.74e-124	366.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42M11@68525|delta/epsilon subdivisions,2WK66@28221|Deltaproteobacteria,2MI46@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_781447_1	883.DvMF_1772	2.44e-20	85.1	COG2204@1|root,COG2204@2|Bacteria,1QUMA@1224|Proteobacteria,43BKZ@68525|delta/epsilon subdivisions,2X6Z5@28221|Deltaproteobacteria,2MH8W@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_781447_2	289376.THEYE_A0734	3.89e-49	161.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_1323017_1	657322.FPR_24250	1.12e-05	51.6	COG0629@1|root,COG0629@2|Bacteria,1V3WT@1239|Firmicutes,24HF9@186801|Clostridia,3WJAP@541000|Ruminococcaceae	186801|Clostridia	L	Single-stranded DNA-binding protein	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_1495121_1	1380387.JADM01000018_gene3385	9.81e-06	53.1	COG0642@1|root,COG0697@1|root,COG0784@1|root,COG0697@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XH82@135619|Oceanospirillales	135619|Oceanospirillales	T	Histidine kinase	-	-	2.7.13.3	ko:K20972,ko:K20973	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,CHASE8,HATPase_c,HisKA,Hpt,PAS_4,Response_reg
k59_89990_1	933262.AXAM01000060_gene2891	8.07e-133	389.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MI07@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	ko:K02481,ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1605699_1	1122604.JONR01000010_gene3829	4.25e-233	684.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1X36Z@135614|Xanthomonadales	135614|Xanthomonadales	E	5-methyltetrahydrofolate--homocysteine methyltransferase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_970833_1	395495.Lcho_3015	5.12e-138	404.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2VIHG@28216|Betaproteobacteria,1KMB7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_911804_2	1454010.JEOE01000001_gene671	1.18e-23	94.4	COG4702@1|root,COG4702@2|Bacteria,2IFGG@201174|Actinobacteria,4F17G@85016|Cellulomonadaceae	201174|Actinobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
k59_1431520_1	768671.ThimaDRAFT_3413	9.15e-146	430.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1WWXP@135613|Chromatiales	135613|Chromatiales	J	small GTP-binding protein	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_1086429_1	396588.Tgr7_2801	1.42e-100	295.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1WVVN@135613|Chromatiales	135613|Chromatiales	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_1495133_1	1499967.BAYZ01000113_gene2944	2.48e-112	332.0	COG0050@1|root,COG0050@2|Bacteria,2NNQV@2323|unclassified Bacteria	2|Bacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_608459_1	1267005.KB911256_gene1760	1.97e-79	249.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2TQSA@28211|Alphaproteobacteria,3N6BH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_608459_2	78245.Xaut_1845	1.27e-15	76.3	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2TTE8@28211|Alphaproteobacteria,3EYBU@335928|Xanthobacteraceae	28211|Alphaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_781456_1	396595.TK90_1668	3.45e-54	172.0	COG1403@1|root,COG1403@2|Bacteria,1RGZQ@1224|Proteobacteria,1S5V4@1236|Gammaproteobacteria,1WYBY@135613|Chromatiales	135613|Chromatiales	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH
k59_1495136_1	748247.AZKH_4168	3.64e-23	100.0	COG3735@1|root,COG3735@2|Bacteria,1RBFT@1224|Proteobacteria,2VTX0@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TraB family	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
k59_843700_1	471853.Bcav_3645	5.41e-18	82.0	COG1704@1|root,COG1704@2|Bacteria,2GPS4@201174|Actinobacteria	201174|Actinobacteria	J	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_1323048_1	318167.Sfri_1560	1.54e-97	298.0	COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,1T2MP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_35296_1	706587.Desti_1435	2.2e-33	116.0	2BZ8Q@1|root,343K9@2|Bacteria,1NAYB@1224|Proteobacteria,42W7G@68525|delta/epsilon subdivisions,2WR8Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_843711_1	1049564.TevJSym_bb00290	2.01e-68	230.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1T216@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg
k59_315383_1	396588.Tgr7_2953	2.95e-18	85.5	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1WX0Q@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
k59_268900_1	331869.BAL199_02404	3.77e-47	158.0	COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria,2TUDH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Chromosome Partitioning	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
k59_1723777_1	935840.JAEQ01000007_gene3882	2.27e-89	271.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2TSWA@28211|Alphaproteobacteria,43ISG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1495162_1	1121939.L861_23580	6.21e-88	268.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1XHSS@135619|Oceanospirillales	135619|Oceanospirillales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1086465_1	545264.KB898746_gene981	4.69e-91	286.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1WX77@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
k59_1782085_1	1121403.AUCV01000026_gene2376	8.8e-62	206.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BWI@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
k59_91448_1	1123065.ATWL01000002_gene1433	3.67e-72	221.0	COG0691@1|root,COG0691@2|Bacteria,2GJX1@201174|Actinobacteria	201174|Actinobacteria	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
k59_614463_1	69395.JQLZ01000002_gene1215	4.34e-56	186.0	COG4798@1|root,COG4798@2|Bacteria,1NNHX@1224|Proteobacteria,2U45K@28211|Alphaproteobacteria,2KGD8@204458|Caulobacterales	204458|Caulobacterales	S	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_1501835_1	1298593.TOL_2823	5.57e-08	60.1	COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,1S28B@1236|Gammaproteobacteria,1XKB0@135619|Oceanospirillales	135619|Oceanospirillales	L	nucleotidyltransferase DNA polymerase involved in DNA repair	-	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
k59_673805_2	1331060.RLDS_11435	1.54e-88	278.0	COG4938@1|root,COG4938@2|Bacteria,1NEEG@1224|Proteobacteria,2UAZA@28211|Alphaproteobacteria,2KBCU@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF3696)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15,DUF3696
k59_438497_1	631362.Thi970DRAFT_01368	1.42e-121	356.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1WW7F@135613|Chromatiales	135613|Chromatiales	EP	PFAM Binding-protein-dependent transport	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1377367_1	446471.Xcel_0788	3.49e-08	52.8	2DMIS@1|root,32RVG@2|Bacteria,2IQ99@201174|Actinobacteria,4F4P2@85017|Promicromonosporaceae	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB7	-	-	ko:K18958	-	-	-	-	ko00000,ko03000	-	-	-	AT_hook,Whib
k59_1377367_2	1095767.CAHD01000148_gene2004	5.15e-20	89.7	COG0476@1|root,COG0476@2|Bacteria,2GMJI@201174|Actinobacteria,4F2HR@85016|Cellulomonadaceae	201174|Actinobacteria	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
k59_673808_1	1158756.AQXQ01000012_gene1224	2.92e-43	144.0	2E4PM@1|root,32P93@2|Bacteria,1N4SK@1224|Proteobacteria,1SEXN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_673808_2	247490.KSU1_C0608	1.12e-81	249.0	COG0426@1|root,COG0426@2|Bacteria,2J1SN@203682|Planctomycetes	203682|Planctomycetes	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1501861_1	1150398.JIBJ01000002_gene1177	4.1e-56	194.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,1WATE@1268|Micrococcaceae	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
k59_1377377_2	870187.Thini_2050	1.31e-24	107.0	2DMSB@1|root,32TC4@2|Bacteria,1R9F1@1224|Proteobacteria,1ST3S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_673822_1	1121033.AUCF01000010_gene4432	7.02e-73	233.0	COG2010@1|root,COG2010@2|Bacteria,1REKI@1224|Proteobacteria,2UA53@28211|Alphaproteobacteria,2JWXG@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_732352_1	1298863.AUEP01000004_gene1944	4.33e-12	69.3	2BE8W@1|root,327ZW@2|Bacteria,2HDR0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_321434_1	2340.JV46_15320	1.71e-83	259.0	COG0446@1|root,COG0446@2|Bacteria,1QUQF@1224|Proteobacteria,1RP1H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	pyridine nucleotide-disulphide oxidoreductase	sqr	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_276905_1	1123229.AUBC01000007_gene39	6.9e-24	97.8	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2UFPB@28211|Alphaproteobacteria,3JZX2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	HPr Serine kinase C-terminal domain	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C
k59_276905_2	1502724.FF80_03038	9.89e-23	90.5	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2U9E5@28211|Alphaproteobacteria,3N6X6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	PFAM PTS system fructose subfamily IIA component	manX	-	2.7.1.191	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1	-	-	EIIA-man
k59_981758_1	1082933.MEA186_11006	3.25e-97	298.0	COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,2U9U2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_1139939_1	1122939.ATUD01000017_gene4041	2.09e-19	87.0	COG2025@1|root,COG2025@2|Bacteria,2GJWH@201174|Actinobacteria,4CPAU@84995|Rubrobacteria	84995|Rubrobacteria	C	Electron transfer flavoprotein domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
k59_1093226_1	443152.MDG893_18257	1.28e-70	221.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,464DZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	COG1192 ATPases involved in chromosome partitioning	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_1093226_2	519989.ECTPHS_08778	8.78e-62	196.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,1WXDT@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
k59_981773_1	1336233.JAEH01000033_gene469	2.86e-47	156.0	COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,1S6BS@1236|Gammaproteobacteria,2QBMX@267890|Shewanellaceae	1236|Gammaproteobacteria	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
k59_981773_2	1198232.CYCME_0792	1.95e-22	94.4	COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,4606H@72273|Thiotrichales	72273|Thiotrichales	P	CBS domain	-	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
k59_1202463_1	247490.KSU1_C1279	1.06e-18	89.4	COG0535@1|root,COG0535@2|Bacteria,2IZE3@203682|Planctomycetes	203682|Planctomycetes	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_1021363_1	1380393.JHVP01000001_gene2301	3.5e-84	278.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2I5GH@201174|Actinobacteria,4EX4D@85013|Frankiales	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc
k59_981776_1	1249627.D779_3766	2.1e-101	308.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,1RQGG@1236|Gammaproteobacteria,1WW8R@135613|Chromatiales	135613|Chromatiales	C	Seven times multi-haem cytochrome CxxCH	-	-	1.7.2.6	ko:K10535	ko00910,ko01120,map00910,map01120	M00528,M00804	R10164	RC00383	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrome_C554,Multi-haem_cyto
k59_1437538_1	110319.CF8_0391	0.000344	48.9	2E5CN@1|root,3304R@2|Bacteria,2IRF6@201174|Actinobacteria,4DS88@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_43876_1	1385519.N801_11155	3.01e-122	368.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,4FFP7@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_145556_1	435908.IDSA_03875	9.47e-44	154.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1SYDD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Transport Permease Protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_1333982_1	296591.Bpro_4816	1.43e-68	223.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2VJ3D@28216|Betaproteobacteria,4ABAW@80864|Comamonadaceae	28216|Betaproteobacteria	Q	D-aminoacylase domain protein	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
k59_100800_1	1121017.AUFG01000019_gene2387	1.18e-92	294.0	COG2213@1|root,COG4668@1|root,COG2213@2|Bacteria,COG4668@2|Bacteria,2GMYR@201174|Actinobacteria	201174|Actinobacteria	G	PTS system mannitol-specific	mtlA	-	2.7.1.197	ko:K02798,ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	M00274	R02704	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5	-	-	PTS_EIIA_2,PTS_EIIC,PTS_IIB
k59_1093244_1	266940.Krad_3553	1.35e-32	121.0	COG1321@1|root,COG1321@2|Bacteria,2GKMC@201174|Actinobacteria	201174|Actinobacteria	K	iron dependent repressor	ideR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
k59_732383_1	395493.BegalDRAFT_2439	1.21e-38	143.0	COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,463NJ@72273|Thiotrichales	72273|Thiotrichales	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB	hscA	-	-	-	-	-	-	-	-	-	-	-	HSP70
k59_981794_1	313590.MED134_04144	2.39e-14	72.4	COG1416@1|root,COG1416@2|Bacteria,4NQQE@976|Bacteroidetes,1I35I@117743|Flavobacteriia,37DPQ@326319|Dokdonia	976|Bacteroidetes	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
k59_981794_2	999419.HMPREF1077_00781	3.73e-42	157.0	COG0574@1|root,COG0745@1|root,COG0574@2|Bacteria,COG0745@2|Bacteria,4NGSQ@976|Bacteroidetes,2FM60@200643|Bacteroidia,22W01@171551|Porphyromonadaceae	976|Bacteroidetes	GKT	Pyruvate phosphate dikinase, PEP pyruvate binding domain	ppsA	-	-	-	-	-	-	-	-	-	-	-	PPDK_N,Response_reg
k59_43891_1	631454.N177_4194	5.34e-11	61.6	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,1JPM2@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	livH	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1139954_1	768671.ThimaDRAFT_0885	1.57e-160	461.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1WWPA@135613|Chromatiales	135613|Chromatiales	S	modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_732390_1	1121405.dsmv_0966	1.45e-53	182.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,42N3P@68525|delta/epsilon subdivisions,2WJB7@28221|Deltaproteobacteria,2MI51@213118|Desulfobacterales	28221|Deltaproteobacteria	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1259	ILVD_EDD
k59_1787821_1	3702.AT4G10320.1	4.46e-104	336.0	COG0060@1|root,KOG0434@2759|Eukaryota,37HS0@33090|Viridiplantae,3G889@35493|Streptophyta,3HQ32@3699|Brassicales	35493|Streptophyta	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010035,GO:0010038,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0019899,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042221,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046686,GO:0050896,GO:0051020,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_1554068_1	593907.Celgi_2024	1.1e-49	179.0	COG1199@1|root,COG1199@2|Bacteria,2GKT8@201174|Actinobacteria,4F0ZQ@85016|Cellulomonadaceae	201174|Actinobacteria	KL	HELICc2	dinG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
k59_1502654_1	1163617.SCD_n01356	2.97e-65	209.0	COG1638@1|root,COG1638@2|Bacteria,1PN6J@1224|Proteobacteria,2VSNQ@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_674595_1	309801.trd_0102	1.93e-17	87.8	COG0147@1|root,COG0147@2|Bacteria,2G5M7@200795|Chloroflexi,27XZ8@189775|Thermomicrobia	189775|Thermomicrobia	H	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_674595_2	1232683.ADIMK_0084	4.81e-88	280.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,464A6@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG0471 Di- and tricarboxylate transporters	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_787142_1	572477.Alvin_2835	1.4e-87	263.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1WX3P@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
k59_1730610_1	1517681.HW45_26610	6.48e-75	241.0	COG2985@1|root,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,1RQ47@1236|Gammaproteobacteria,1XWS1@135623|Vibrionales	135623|Vibrionales	U	Predicted Permease Membrane Region	-	-	-	-	-	-	-	-	-	-	-	-	Asp-Al_Ex
k59_982919_1	1395571.TMS3_0119335	1.13e-39	151.0	COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a)	lpoA	GO:0000270,GO:0003674,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	-	ko:K07121	-	-	-	-	ko00000	-	-	-	LppC
k59_1438276_1	926566.Terro_2836	3.07e-54	181.0	COG0451@1|root,COG0451@2|Bacteria,3Y3ZG@57723|Acidobacteria,2JHT7@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_787145_2	765914.ThisiDRAFT_1963	1.81e-35	127.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RSQ8@1236|Gammaproteobacteria,1WWKV@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM Succinate dehydrogenase fumarate reductase iron-sulphur protein	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
k59_1554076_1	324925.Ppha_2923	0.000725	43.1	COG0594@1|root,COG0594@2|Bacteria,1FEB5@1090|Chlorobi	1090|Chlorobi	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
k59_498045_1	1499967.BAYZ01000056_gene4882	4.89e-68	232.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K07713,ko:K07714	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,PEP_hydrolase,Sigma54_activat
k59_1612276_2	1380354.JIAN01000005_gene2724	1.27e-51	170.0	COG1309@1|root,COG1309@2|Bacteria,2I8DN@201174|Actinobacteria,4F1AF@85016|Cellulomonadaceae	201174|Actinobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
k59_1022003_1	105559.Nwat_0028	2.6e-187	534.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1WVW7@135613|Chromatiales	135613|Chromatiales	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_1022003_2	1323663.AROI01000051_gene4003	6.5e-25	103.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	peptidase	envC	GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1673222_1	1323663.AROI01000009_gene3504	5.06e-61	211.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component	ybbP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_1094016_1	261292.Nit79A3_2092	8.18e-100	300.0	COG3001@1|root,COG3001@2|Bacteria,1MVHX@1224|Proteobacteria,2VN04@28216|Betaproteobacteria,372SJ@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Fructosamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Fructosamin_kin
k59_1335147_1	645465.ACUR01000585_gene3493	9.93e-34	119.0	COG1993@1|root,COG1993@2|Bacteria,2IM7J@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
k59_1502679_1	1249627.D779_3023	1.76e-83	259.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales	135613|Chromatiales	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
k59_101960_1	713586.KB900536_gene3059	5.35e-173	496.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales	135613|Chromatiales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_1335148_1	472759.Nhal_0222	1.75e-189	563.0	COG0784@1|root,COG2199@1|root,COG2200@1|root,COG0784@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1WWNV@135613|Chromatiales	135613|Chromatiales	T	PFAM EAL domain	-	-	-	ko:K21025	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg
k59_498062_1	1442599.JAAN01000015_gene3195	1.04e-12	66.6	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,1X4I1@135614|Xanthomonadales	135614|Xanthomonadales	P	Sulfurtransferase	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_498062_2	42565.FP66_02955	2.54e-36	140.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,1XHHF@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
k59_615242_1	367299.JOEE01000009_gene330	1.05e-115	341.0	COG0042@1|root,COG0042@2|Bacteria,2GJ8I@201174|Actinobacteria,4FFGK@85021|Intrasporangiaceae	201174|Actinobacteria	J	tRNA-dihydrouridine synthase	dus	GO:0008150,GO:0010565,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0080090	-	-	-	-	-	-	-	-	-	-	Dus
k59_204937_1	864051.BurJ1DRAFT_3430	7.91e-49	164.0	COG3222@1|root,COG3222@2|Bacteria,1RB1V@1224|Proteobacteria,2VRM0@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
k59_204937_2	522306.CAP2UW1_2822	5.78e-46	154.0	COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,2VQQD@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1863456_1	1123320.KB889662_gene1547	5.95e-37	139.0	COG1929@1|root,COG1929@2|Bacteria,2GKHX@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycerate kinase type-1 family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
k59_101973_1	870187.Thini_1214	5.88e-13	71.2	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,460CN@72273|Thiotrichales	72273|Thiotrichales	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_1554105_1	365528.KB891208_gene3114	2.4e-51	173.0	COG2141@1|root,COG2141@2|Bacteria,2GM7W@201174|Actinobacteria,4ERJD@85013|Frankiales	201174|Actinobacteria	C	PFAM Luciferase-like	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_44895_2	471853.Bcav_2610	1.83e-91	272.0	COG1045@1|root,COG1045@2|Bacteria,2IHW5@201174|Actinobacteria	201174|Actinobacteria	E	Serine acetyltransferase	cysE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
k59_982978_1	880072.Desac_0544	4.25e-78	259.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MSJC@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	por	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_439333_1	311403.Arad_15024	1.95e-05	53.1	COG2244@1|root,COG2244@2|Bacteria,1MZWN@1224|Proteobacteria	1224|Proteobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3
k59_1335172_1	58123.JOFJ01000001_gene3028	2.68e-72	243.0	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4EHRZ@85012|Streptosporangiales	201174|Actinobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_556627_1	1158165.KB898874_gene1733	7.62e-24	99.4	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1WX54@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_556627_2	1211114.ALIP01000159_gene350	1.79e-38	139.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1X4R7@135614|Xanthomonadales	135614|Xanthomonadales	E	Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
k59_850399_1	367299.JOEE01000001_gene1912	9.17e-15	74.7	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2GJU7@201174|Actinobacteria,4FFX9@85021|Intrasporangiaceae	201174|Actinobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
k59_850399_2	367299.JOEE01000001_gene1913	5.92e-32	115.0	COG3255@1|root,COG3255@2|Bacteria,2IFWK@201174|Actinobacteria,4FH6K@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acyl-CoA synthase	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
k59_439337_1	96561.Dole_1930	3.36e-58	187.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria,2MJ7C@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1140594_1	8090.ENSORLP00000004959	1.99e-33	133.0	2AIEU@1|root,2RZ4M@2759|Eukaryota,39NWY@33154|Opisthokonta,3CQF8@33208|Metazoa,3E6MD@33213|Bilateria	33208|Metazoa	S	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_Tnp_Tc3_2
k59_395462_2	298386.PBPRA0169	5.42e-47	158.0	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,1S5XA@1236|Gammaproteobacteria,1XVB6@135623|Vibrionales	135623|Vibrionales	O	COG3175 Cytochrome oxidase assembly factor	coxG	-	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
k59_51329_1	309799.DICTH_0565	1.43e-53	177.0	COG5012@1|root,COG5012@2|Bacteria	2|Bacteria	T	cobalamin binding	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,URO-D
k59_109305_1	1121035.AUCH01000019_gene2858	1.2e-44	159.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2VHH5@28216|Betaproteobacteria,2KVKZ@206389|Rhodocyclales	206389|Rhodocyclales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
k59_1791781_2	713586.KB900536_gene2663	5.66e-32	114.0	COG2863@1|root,COG2863@2|Bacteria,1MZU1@1224|Proteobacteria,1SBJR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_326708_1	1255043.TVNIR_1350	8.85e-149	452.0	28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria,1S1M3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
k59_737926_1	765911.Thivi_4465	9.86e-83	256.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1WWQH@135613|Chromatiales	135613|Chromatiales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	ko:K13283	-	-	-	-	ko00000,ko02000	2.A.4.7.1	-	-	Cation_efflux,ZT_dimer
k59_52132_3	519989.ECTPHS_00090	7.91e-40	145.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1WX4Z@135613|Chromatiales	135613|Chromatiales	S	AI-2E family transporter	-	-	-	ko:K03548	-	-	-	-	ko00000,ko02000	2.A.86.1	-	-	AI-2E_transport
k59_1343750_1	1123377.AUIV01000003_gene1768	1.61e-71	225.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1X3ZT@135614|Xanthomonadales	135614|Xanthomonadales	C	Heme copper-type cytochrome quinol oxidase subunit 3	cox3	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_791436_1	110319.CF8_2797	1.52e-35	133.0	COG1063@1|root,COG1063@2|Bacteria,2H3Y2@201174|Actinobacteria	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	-	ko:K19956	ko00051,map00051	-	R03234	RC00089	ko00000,ko00001,ko01000	-	-	-	ADH_N
k59_110393_1	1121405.dsmv_1084	1.69e-107	315.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria,2MIHA@213118|Desulfobacterales	28221|Deltaproteobacteria	N	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
k59_1026401_1	289376.THEYE_A0758	2.71e-107	331.0	COG0466@1|root,COG0466@2|Bacteria,3J0DQ@40117|Nitrospirae	40117|Nitrospirae	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,Lon_C,Response_reg
k59_1383765_1	768671.ThimaDRAFT_4485	3.09e-07	58.9	COG0265@1|root,COG1075@1|root,COG2304@1|root,COG0265@2|Bacteria,COG1075@2|Bacteria,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	MA20_07505	-	1.1.3.6,1.6.5.3,3.4.21.107	ko:K00337,ko:K03333,ko:K04771,ko:K07114	ko00190,ko00984,ko01100,ko01120,ko01503,ko02020,map00190,map00984,map01100,map01120,map01503,map02020	M00144,M00728	R01459,R11945	RC00061,RC00146	ko00000,ko00001,ko00002,ko01000,ko01002,ko02000,ko03110	1.A.13.2.2,1.A.13.2.3,3.D.1	-	-	DUF1194
k59_738726_1	1304865.JAGF01000001_gene1675	6.43e-117	347.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4F24W@85016|Cellulomonadaceae	201174|Actinobacteria	E	PFAM aspartate glutamate uridylate kinase	ask	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
k59_1343773_1	795955.AFRW01000102_gene1988	2.22e-60	194.0	COG1125@1|root,COG1125@2|Bacteria,2GJHI@201174|Actinobacteria,1W7U5@1268|Micrococcaceae	201174|Actinobacteria	E	ABC transporter	proV	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	iNJ661.Rv3758c	ABC_tran
k59_503221_1	469383.Cwoe_5040	6.87e-58	189.0	COG4608@1|root,COG4608@2|Bacteria,2GMCD@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
k59_52150_1	1454004.AW11_00566	2.61e-38	135.0	COG1392@1|root,COG1392@2|Bacteria,1MXY9@1224|Proteobacteria	1224|Proteobacteria	P	Phosphate transport regulator (Distant homolog of PhoU)	UF78_21250	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_1508565_1	977880.RALTA_A1406	6.92e-79	246.0	COG3713@1|root,COG3713@2|Bacteria,1R5JE@1224|Proteobacteria,2VKVW@28216|Betaproteobacteria,1K3JQ@119060|Burkholderiaceae	28216|Betaproteobacteria	M	MltA-interacting protein MipA	-	-	-	-	-	-	-	-	-	-	-	-	MipA
k59_1145234_1	309801.trd_0495	5.85e-97	299.0	COG2225@1|root,COG2225@2|Bacteria,2G63R@200795|Chloroflexi,27Y0V@189775|Thermomicrobia	189775|Thermomicrobia	C	Malate synthase	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_738727_1	768671.ThimaDRAFT_3297	3.48e-118	355.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RYB4@1236|Gammaproteobacteria,1WVUT@135613|Chromatiales	135613|Chromatiales	CP	PFAM NADH Ubiquinone plastoquinone	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_738727_2	765913.ThidrDRAFT_4027	3.28e-26	99.8	COG1006@1|root,COG1006@2|Bacteria,1N7TX@1224|Proteobacteria,1SD0U@1236|Gammaproteobacteria,1WYVT@135613|Chromatiales	135613|Chromatiales	P	oxidoreductase, chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
k59_1343778_1	1122135.KB893137_gene1273	8.4e-81	259.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,2TT6P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC-type oligopeptide transport system periplasmic component	-	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
k59_991546_1	1095767.CAHD01000213_gene574	3.47e-38	138.0	COG3832@1|root,COG3832@2|Bacteria,2IBWM@201174|Actinobacteria	201174|Actinobacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_991546_2	118005.AWNK01000010_gene295	2.34e-12	68.2	COG1109@1|root,COG2819@1|root,COG1109@2|Bacteria,COG2819@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	algC	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Esterase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_327548_1	446468.Ndas_3454	2.88e-10	63.2	COG0582@1|root,COG0582@2|Bacteria,2IHIW@201174|Actinobacteria,4EHFB@85012|Streptosporangiales	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
k59_151882_1	326427.Cagg_1166	6.31e-77	247.0	COG2414@1|root,COG2414@2|Bacteria,2G5XP@200795|Chloroflexi,376PZ@32061|Chloroflexia	32061|Chloroflexia	C	PFAM aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_1559561_1	367299.JOEE01000004_gene1018	1.49e-59	204.0	COG3119@1|root,COG3119@2|Bacteria,2H59R@201174|Actinobacteria,4FECJ@85021|Intrasporangiaceae	201174|Actinobacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1617795_1	1502852.FG94_01101	5.53e-82	246.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2VIJ2@28216|Betaproteobacteria,472VR@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Cytochrome C oxidase, mono-heme subunit/FixO	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
k59_403965_1	335543.Sfum_3495	2.31e-106	316.0	COG1840@1|root,COG1840@2|Bacteria,1PFBM@1224|Proteobacteria,4324D@68525|delta/epsilon subdivisions,2WX6N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
k59_110436_1	1128421.JAGA01000002_gene776	3.67e-24	102.0	COG3342@1|root,COG3342@2|Bacteria,2NP87@2323|unclassified Bacteria	2|Bacteria	S	Family of unknown function (DUF1028)	fimA	-	-	-	-	-	-	-	-	-	-	-	DUF1028,PG_binding_2
k59_1792511_1	572477.Alvin_3088	7.02e-81	250.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1WWT0@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_1871988_1	324831.LGAS_0275	3.5e-13	75.9	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,4H9ZM@91061|Bacilli,3F4GY@33958|Lactobacillaceae	91061|Bacilli	J	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	2.4.2.8,6.3.4.19	ko:K04075,ko:K15780	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01132,R01229,R02142,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
k59_403975_2	1121035.AUCH01000013_gene3093	5.54e-63	199.0	COG3383@1|root,COG3383@2|Bacteria,1MXTC@1224|Proteobacteria,2WGYK@28216|Betaproteobacteria,2KZWV@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S single cluster domain	-	-	1.12.1.2	ko:K18006	-	-	-	-	ko00000,ko01000	-	-	-	Fer2_4,Fer4_15,NADH-G_4Fe-4S_3
k59_1792514_1	585531.HMPREF0063_10534	1.71e-71	239.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4DNJG@85009|Propionibacteriales	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1099758_1	1357272.AVEO02000073_gene4564	8.37e-114	338.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,1Z6H0@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_1274224_1	1041147.AUFB01000094_gene5706	4.94e-100	304.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U1Z0@28211|Alphaproteobacteria,4BMWU@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986,ko:K15342	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	Cas_Cas1,GIIM,RVT_1
k59_151905_1	565045.NOR51B_1219	2.52e-19	92.0	COG1520@1|root,COG1520@2|Bacteria,1QU2U@1224|Proteobacteria,1S1NX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Dehydrogenase	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3
k59_561842_1	765913.ThidrDRAFT_2417	1.12e-140	401.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,1RS6A@1236|Gammaproteobacteria,1WWKN@135613|Chromatiales	135613|Chromatiales	C	C-type monoheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the intermediary formation of conspicuous sulfur globules inside of the cells	-	-	-	ko:K17222	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	-
k59_1274226_1	768671.ThimaDRAFT_2470	7.16e-72	225.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1WWP3@135613|Chromatiales	135613|Chromatiales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_403990_1	395493.BegalDRAFT_0683	4.82e-51	177.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria,460G5@72273|Thiotrichales	72273|Thiotrichales	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3329,HATPase_c,HisKA,PAS,PAS_8
k59_932405_1	472759.Nhal_3760	4.28e-44	161.0	COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1RMSA@1236|Gammaproteobacteria,1X07Q@135613|Chromatiales	135613|Chromatiales	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_620492_1	1207076.ALAT01000099_gene2504	1.73e-47	167.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1Z190@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	fleR	-	-	ko:K10943	ko02020,ko05111,map02020,map05111	M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_932406_1	1163408.UU9_15832	5.01e-47	160.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1X4SF@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
k59_932406_2	1123073.KB899242_gene1407	1.14e-29	109.0	COG4496@1|root,COG4496@2|Bacteria,1NAAX@1224|Proteobacteria,1SG3S@1236|Gammaproteobacteria,1X7DY@135614|Xanthomonadales	135614|Xanthomonadales	S	protein, YerC YecD	-	-	-	-	-	-	-	-	-	-	-	-	Trp_repressor
k59_1508615_1	396588.Tgr7_2273	5.41e-55	176.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria,1WY5P@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
k59_327585_1	1461694.ATO9_12480	1.76e-24	110.0	COG0771@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2V8V8@28211|Alphaproteobacteria,2PFGF@252301|Oceanicola	28211|Alphaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_210317_1	948565.AFFP02000001_gene935	2.38e-07	54.7	COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria,1Y8FB@135625|Pasteurellales	135625|Pasteurellales	S	colicin V production	cvpA	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
k59_1443636_1	261292.Nit79A3_0158	1.32e-191	546.0	COG5433@1|root,COG5433@2|Bacteria,1MXI8@1224|Proteobacteria,2W66H@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_932416_1	1056820.KB900644_gene787	1.43e-13	77.0	COG4644@1|root,COG4644@2|Bacteria,1MUIU@1224|Proteobacteria,1RPZZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_Tn3,DUF4158
k59_991618_1	880072.Desac_2372	4.13e-70	221.0	COG1463@1|root,COG1463@2|Bacteria,1Q6ZU@1224|Proteobacteria,42RZ3@68525|delta/epsilon subdivisions,2WNF0@28221|Deltaproteobacteria,2MRII@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	MlaD protein	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_932421_2	362976.HQ_3700A	1.81e-21	97.1	COG2021@1|root,arCOG00627@2157|Archaea,2XTYY@28890|Euryarchaeota,23SBX@183963|Halobacteria	183963|Halobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_680186_1	1297742.A176_04407	6.22e-68	233.0	COG4630@1|root,COG4631@1|root,COG4630@2|Bacteria,COG4631@2|Bacteria,1NQSR@1224|Proteobacteria,43C3C@68525|delta/epsilon subdivisions,2X7DZ@28221|Deltaproteobacteria,2YWS9@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	xdhB	-	1.17.1.4	ko:K13482	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
k59_1443643_2	1304878.AUGD01000001_gene679	1.52e-46	166.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2TRMJ@28211|Alphaproteobacteria,3JT3T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	ATP-dependent helicase	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_1343867_2	1500890.JQNL01000001_gene357	6.08e-31	127.0	COG2199@1|root,COG3292@1|root,COG3292@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RQCR@1236|Gammaproteobacteria,1X4SZ@135614|Xanthomonadales	135614|Xanthomonadales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Reg_prop,Y_Y_Y
k59_404031_1	1828.JOKB01000010_gene5286	3.38e-138	417.0	COG0582@1|root,COG0582@2|Bacteria,2GNTJ@201174|Actinobacteria,4FWST@85025|Nocardiaceae	201174|Actinobacteria	L	PFAM phage integrase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
k59_1678623_1	1713.JOFV01000008_gene3221	2.48e-10	61.2	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4F0TS@85016|Cellulomonadaceae	201174|Actinobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_1678623_2	1385935.N836_21815	2.81e-88	270.0	COG0454@1|root,COG0454@2|Bacteria,1G5K5@1117|Cyanobacteria,1HCUQ@1150|Oscillatoriales	1117|Cyanobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1026467_2	266940.Krad_4119	2.29e-22	94.4	COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria	201174|Actinobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_1617851_1	1000565.METUNv1_01919	2.84e-82	256.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2VHBB@28216|Betaproteobacteria,2KUR1@206389|Rhodocyclales	206389|Rhodocyclales	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_680199_1	2340.JV46_13940	6.92e-119	353.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,1RN8U@1236|Gammaproteobacteria,1J4X4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumA	GO:0003674,GO:0003824,GO:0004333,GO:0005488,GO:0005515,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016862,GO:0016999,GO:0017144,GO:0019752,GO:0033554,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0047808,GO:0048037,GO:0050163,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_1778,iPC815.YPO3335	Fumerase,Fumerase_C
k59_52247_1	234267.Acid_4435	1.89e-32	130.0	COG3303@1|root,COG3303@2|Bacteria,3Y84F@57723|Acidobacteria	57723|Acidobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_991645_1	882083.SacmaDRAFT_3669	3.89e-112	330.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4DZDF@85010|Pseudonocardiales	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit	acoB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_1099808_1	66373.JOFQ01000013_gene6801	4.83e-40	145.0	COG0438@1|root,COG0438@2|Bacteria,2GN28@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
k59_1872074_1	1121875.KB907555_gene348	3.23e-06	55.8	COG4888@1|root,COG4888@2|Bacteria,4NEE8@976|Bacteroidetes,1HX4C@117743|Flavobacteriia	976|Bacteroidetes	S	PFAM ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_1343889_1	204773.HEAR0081	1.51e-69	226.0	COG1032@1|root,COG1032@2|Bacteria,1Q5NG@1224|Proteobacteria,2VPEG@28216|Betaproteobacteria,472QT@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Protein of unknown function (DUF4080)	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
k59_1343889_2	1283284.AZUK01000002_gene2796	8.02e-26	107.0	COG0224@1|root,COG0224@2|Bacteria,1RIE5@1224|Proteobacteria,1S3ZW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	ATP synthase gamma subunit	-	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_738810_1	382464.ABSI01000011_gene3134	1.9e-14	73.6	COG0303@1|root,COG0303@2|Bacteria,46SZB@74201|Verrucomicrobia,2IUKH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	MoeA N-terminal region (domain I and II)	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_738810_2	1163408.UU9_06274	6.44e-35	132.0	COG0314@1|root,COG0476@1|root,COG0314@2|Bacteria,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,1X3YQ@135614|Xanthomonadales	135614|Xanthomonadales	H	ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase	moeB	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,ThiF
k59_210353_1	717785.HYPMC_2879	1.62e-80	252.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2TRBX@28211|Alphaproteobacteria,3N6BX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_1208442_1	35754.JNYJ01000042_gene1381	3.51e-182	536.0	COG0068@1|root,COG0068@2|Bacteria,2GJYF@201174|Actinobacteria,4DID7@85008|Micromonosporales	201174|Actinobacteria	O	Acylphosphatase	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_1735970_1	909663.KI867149_gene3364	1.67e-96	296.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,42N30@68525|delta/epsilon subdivisions,2WJSW@28221|Deltaproteobacteria,2MQT1@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_738813_1	396595.TK90_0435	3.45e-120	363.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1WW6M@135613|Chromatiales	135613|Chromatiales	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
k59_561896_1	1117647.M5M_04175	2.37e-12	67.8	COG2933@1|root,COG2933@2|Bacteria,1MWBM@1224|Proteobacteria,1RMSB@1236|Gammaproteobacteria,1J4FE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily	rlmM	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.186	ko:K06968	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
k59_561896_2	156889.Mmc1_3551	6.01e-16	79.3	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases	-	-	1.1.1.31,1.1.1.411	ko:K00020,ko:K08319	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_1274296_1	1416752.AYME01000003_gene3028	9.46e-81	244.0	COG0396@1|root,COG0396@2|Bacteria,2GKB7@201174|Actinobacteria,4FMJI@85023|Microbacteriaceae	201174|Actinobacteria	O	ATPases associated with a variety of cellular activities	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
k59_1274296_2	273677.BW34_00133	3.82e-15	69.7	COG2146@1|root,COG2146@2|Bacteria,2IQK7@201174|Actinobacteria,4FP2S@85023|Microbacteriaceae	201174|Actinobacteria	P	Rieske-like [2Fe-2S] domain	hcaC	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
k59_285031_1	2340.JV46_29190	3.82e-272	759.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1J4HN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_110560_1	367299.JOEE01000012_gene3237	1.43e-16	77.4	COG0613@1|root,COG0613@2|Bacteria,2GNAP@201174|Actinobacteria,4FF9Y@85021|Intrasporangiaceae	201174|Actinobacteria	S	Metal-dependent phosphoesterase	PPA1328	-	3.1.3.97,3.1.4.57	ko:K07053,ko:K20859	ko00440,map00440	-	R00188,R10972,R10973,R11188	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	PHP
k59_110560_2	367299.JOEE01000012_gene3236	1.29e-45	152.0	COG1595@1|root,COG1595@2|Bacteria,2GN65@201174|Actinobacteria,4FGT6@85021|Intrasporangiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
k59_680224_1	391735.Veis_3161	3.94e-15	72.0	COG2236@1|root,COG2236@2|Bacteria,1R675@1224|Proteobacteria,2VPZG@28216|Betaproteobacteria,4AA1G@80864|Comamonadaceae	28216|Betaproteobacteria	F	PFAM Phosphoribosyltransferase	gpt	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
k59_680224_2	882378.RBRH_03721	2.08e-47	164.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2VHBR@28216|Betaproteobacteria,1K370@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_798069_2	1463821.JOGR01000005_gene2892	1.31e-53	172.0	COG2001@1|root,COG2001@2|Bacteria,2IHUB@201174|Actinobacteria,4EYNZ@85014|Glycomycetales	201174|Actinobacteria	K	MraZ protein, putative antitoxin-like	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
k59_570347_1	1267005.KB911255_gene3037	7.11e-70	225.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2U0K2@28211|Alphaproteobacteria,3N6RA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Ami_3	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
k59_1036203_1	1120948.KB903229_gene5185	7.44e-07	53.9	COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4DX45@85010|Pseudonocardiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1109531_1	977880.RALTA_B0169	1.03e-32	129.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,1K0B4@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	mucD	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_1152816_1	1552758.NC00_07235	3.05e-08	55.5	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,1RQAM@1236|Gammaproteobacteria,1X3CG@135614|Xanthomonadales	135614|Xanthomonadales	S	N-acyl-L-amino acid amidohydrolase	amaA	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_1152816_2	1163407.UU7_12399	1.83e-75	239.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,1RMMB@1236|Gammaproteobacteria,1X2Y7@135614|Xanthomonadales	135614|Xanthomonadales	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	-	-	-	-	-	-	-	-	-	-	-	-	RsgA_GTPase
k59_1687126_1	1417296.U879_08080	1.12e-53	179.0	COG0446@1|root,COG1148@1|root,COG0446@2|Bacteria,COG1148@2|Bacteria,1R882@1224|Proteobacteria,2U526@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD dependent oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Pyr_redox_2
k59_1518200_1	1142394.PSMK_08370	1.77e-65	214.0	COG1077@1|root,COG1077@2|Bacteria	2|Bacteria	D	Cell shape determining protein MreB Mrl	mreB2	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_218496_1	1235792.C808_04326	3.26e-45	160.0	COG1397@1|root,COG1397@2|Bacteria,1U2AQ@1239|Firmicutes,24KT9@186801|Clostridia	186801|Clostridia	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
k59_218496_2	1298920.KI911353_gene150	8.66e-11	63.5	COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,21ZN7@1506553|Lachnoclostridium	186801|Clostridia	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_798080_1	439235.Dalk_4360	4.28e-52	181.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria,2MHYJ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM glutamate synthase (NADPH), homotetrameric	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_864171_1	411902.CLOBOL_02296	5.92e-81	257.0	COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,21Z1Z@1506553|Lachnoclostridium	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
k59_1626008_1	1384054.N790_05985	6.75e-41	144.0	COG1073@1|root,COG1073@2|Bacteria,1R1F2@1224|Proteobacteria,1T507@1236|Gammaproteobacteria,1XDHB@135614|Xanthomonadales	135614|Xanthomonadales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
k59_453186_1	1121028.ARQE01000011_gene190	1.01e-80	253.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2TQYQ@28211|Alphaproteobacteria,2PJ9I@255475|Aurantimonadaceae	28211|Alphaproteobacteria	P	Domain of unknown function (DUF3333)	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
k59_1216896_1	349124.Hhal_1707	5.43e-89	283.0	COG1205@1|root,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,1S0XD@1236|Gammaproteobacteria,1WXNC@135613|Chromatiales	135613|Chromatiales	L	DEAD DEAH box	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
k59_688511_1	744980.TRICHSKD4_5080	6.33e-60	197.0	COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2TS1S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_453189_1	864051.BurJ1DRAFT_4252	8.11e-16	72.8	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2VR5S@28216|Betaproteobacteria,1KKUJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
k59_453189_2	572477.Alvin_1906	3.11e-143	416.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1WWPY@135613|Chromatiales	135613|Chromatiales	I	TIGRFAM acetyl-CoA carboxylase, biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_1452200_1	880073.Calab_2021	1.14e-32	120.0	COG0852@1|root,COG0852@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_1452200_2	1408473.JHXO01000009_gene3412	2.86e-09	55.8	COG0377@1|root,COG0377@2|Bacteria,4NFKT@976|Bacteroidetes,2FMK8@200643|Bacteroidia	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	ndhK	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_218527_1	1217718.ALOU01000007_gene1258	1.49e-05	47.8	COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,2W0N2@28216|Betaproteobacteria	28216|Betaproteobacteria	O	PPIC-type PPIASE domain	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase_2
k59_218527_2	981384.AEYW01000003_gene2002	2.5e-15	76.3	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4ND0W@97050|Ruegeria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_1452209_1	387093.SUN_1618	1.21e-56	179.0	COG0848@1|root,COG0848@2|Bacteria,1N9DN@1224|Proteobacteria,42V0H@68525|delta/epsilon subdivisions,2YQ7R@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	U	biopolymer transport protein	exbD2	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_1744913_1	1504319.GM45_4135	1.39e-74	235.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,3UWKD@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Belongs to the complex I 49 kDa subunit family	nuoD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_1744913_2	1410634.JHVD01000011_gene2241	1.62e-11	63.5	COG1905@1|root,COG1905@2|Bacteria,2GKG0@201174|Actinobacteria,4DN2R@85009|Propionibacteriales	201174|Actinobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_1518260_1	754477.Q7C_2462	3.03e-170	494.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,46011@72273|Thiotrichales	72273|Thiotrichales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_1567813_1	1267005.KB911256_gene1988	6.22e-61	213.0	COG2982@1|root,COG2982@2|Bacteria,1QWQT@1224|Proteobacteria,2TX2D@28211|Alphaproteobacteria,3N6W2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_218539_1	1125863.JAFN01000001_gene1218	8.76e-23	102.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_570394_1	765912.Thimo_0678	1.88e-42	154.0	COG3359@1|root,COG3359@2|Bacteria,1R5KG@1224|Proteobacteria,1RY3P@1236|Gammaproteobacteria,1WXHZ@135613|Chromatiales	135613|Chromatiales	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
k59_629344_1	220341.16502491	5.33e-40	142.0	COG1842@1|root,COG1842@2|Bacteria,1NC7S@1224|Proteobacteria,1RS0G@1236|Gammaproteobacteria,3ZJJV@590|Salmonella	1236|Gammaproteobacteria	KT	PspA/IM30 family	pspA	GO:0003674,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0008289,GO:0009266,GO:0009271,GO:0009408,GO:0009605,GO:0009607,GO:0009615,GO:0009628,GO:0009889,GO:0009898,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019897,GO:0019898,GO:0031234,GO:0031323,GO:0031326,GO:0042802,GO:0043167,GO:0043168,GO:0043207,GO:0043433,GO:0044092,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0050896,GO:0051090,GO:0051171,GO:0051252,GO:0051704,GO:0051707,GO:0060187,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0098552,GO:0098562,GO:0098586,GO:1903506,GO:2000112,GO:2001141	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
k59_747313_2	768671.ThimaDRAFT_2708	3.67e-63	201.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,1RMR5@1236|Gammaproteobacteria,1WYK9@135613|Chromatiales	135613|Chromatiales	G	Isocitrate lyase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
k59_864221_1	870187.Thini_1175	6.04e-35	133.0	COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,1RP3E@1236|Gammaproteobacteria,45ZZS@72273|Thiotrichales	72273|Thiotrichales	M	Belongs to the BCCT transporter (TC 2.A.15) family	-	-	-	ko:K02168,ko:K03451	-	-	-	-	ko00000,ko02000	2.A.15,2.A.15.1.3,2.A.15.1.4	-	-	BCCT
k59_1284173_1	1254432.SCE1572_40490	4.48e-97	298.0	COG0539@1|root,COG2183@1|root,COG0539@2|Bacteria,COG2183@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2YU9B@29|Myxococcales	28221|Deltaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_1518287_1	1121406.JAEX01000005_gene3049	4.89e-58	191.0	COG0765@1|root,COG0765@2|Bacteria,1MX3E@1224|Proteobacteria,42N9B@68525|delta/epsilon subdivisions,2WIYW@28221|Deltaproteobacteria,2M9VH@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	-	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1,SBP_bac_3
k59_1799908_1	335541.Swol_1118	9.15e-30	122.0	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,42JRM@68298|Syntrophomonadaceae	186801|Clostridia	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	nolG2	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_160318_1	887898.HMPREF0551_2285	0.000855	40.0	COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2VUFB@28216|Betaproteobacteria,1K8M3@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
k59_160318_2	553217.ENHAE0001_0879	1.41e-47	166.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,3NIMZ@468|Moraxellaceae	1236|Gammaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_1626056_1	234267.Acid_1377	6.55e-09	61.2	COG2244@1|root,COG2244@2|Bacteria,3Y8IW@57723|Acidobacteria	57723|Acidobacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1284180_1	1499967.BAYZ01000074_gene2163	1.07e-45	166.0	COG0342@1|root,COG0342@2|Bacteria,2NNNU@2323|unclassified Bacteria	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_798115_1	1304865.JAGF01000001_gene3158	2.87e-88	286.0	COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria,4F0Y6@85016|Cellulomonadaceae	201174|Actinobacteria	L	DEAD DEAH box helicase domain protein	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
k59_160319_1	1123253.AUBD01000011_gene2078	3.75e-182	527.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,1RYFT@1236|Gammaproteobacteria,1X3IT@135614|Xanthomonadales	1236|Gammaproteobacteria	EU	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_1518301_1	1713.JOFV01000001_gene2068	5.92e-23	98.6	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87,Zot
k59_1744944_1	1187851.A33M_2236	2.99e-67	210.0	COG5385@1|root,COG5385@2|Bacteria,1MVEY@1224|Proteobacteria,2TSE6@28211|Alphaproteobacteria,3FDG9@34008|Rhodovulum	28211|Alphaproteobacteria	S	Histidine phosphotransferase C-terminal domain	MA20_46320	-	-	ko:K13588	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001	-	-	-	HPTransfase
k59_1567853_1	710696.Intca_0074	1.18e-114	343.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	gtsA	-	-	ko:K17315	ko02010,map02010	M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.24,3.A.1.1.30	-	-	SBP_bac_1,SBP_bac_8
k59_511973_1	1202962.KB907154_gene751	4.18e-11	69.7	29I5E@1|root,3052G@2|Bacteria,1QR7E@1224|Proteobacteria,1SMYW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Flagellar assembly protein T, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FlgT_N
k59_629374_1	1540221.JQNI01000002_gene2813	1.23e-54	186.0	COG0730@1|root,COG2391@1|root,COG0730@2|Bacteria,COG2391@2|Bacteria,1WIAC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_570438_2	1249627.D779_0665	1.65e-33	121.0	2AAM4@1|root,30ZYM@2|Bacteria,1RFTG@1224|Proteobacteria,1S4UQ@1236|Gammaproteobacteria,1WYA8@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_336646_1	658187.LDG_9061	1.67e-84	265.0	COG3385@1|root,COG3385@2|Bacteria,1R8M9@1224|Proteobacteria,1S1W5@1236|Gammaproteobacteria,1JDGB@118969|Legionellales	118969|Legionellales	L	to transposase (IS4 family)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_160348_1	991905.SL003B_2304	3.63e-74	234.0	COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,2TW9Z@28211|Alphaproteobacteria,4BPHC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	V	Barrel-sandwich domain of CusB or HlyD membrane-fusion	yhiI	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1746507_3	1454004.AW11_01123	1.41e-69	217.0	COG0356@1|root,COG0356@2|Bacteria,1RBEV@1224|Proteobacteria,2WGC1@28216|Betaproteobacteria	28216|Betaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	-	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1286469_2	751945.Theos_0129	2.85e-26	107.0	COG0165@1|root,COG0165@2|Bacteria,1WI7D@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_1038072_1	1125863.JAFN01000001_gene1439	2.18e-63	210.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	DUF3347,HlyD_D23
k59_513434_1	1151126.AQYI01000002_gene290	1.28e-24	110.0	COG0739@1|root,COG0739@2|Bacteria,2GXEC@201174|Actinobacteria,4FTBE@85023|Microbacteriaceae	201174|Actinobacteria	M	Peptidase family M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
k59_630910_1	96561.Dole_1179	7.46e-32	121.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,42PSG@68525|delta/epsilon subdivisions,2WKYN@28221|Deltaproteobacteria,2MJ9P@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
k59_866179_1	1049564.TevJSym_aa01830	2.94e-55	193.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1SNU0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_454680_2	768671.ThimaDRAFT_3380	1.23e-17	82.4	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,1WXSE@135613|Chromatiales	135613|Chromatiales	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	-	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
k59_1154380_2	1121918.ARWE01000001_gene2400	9.51e-25	99.4	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1MW67@1224|Proteobacteria,42SGH@68525|delta/epsilon subdivisions,2X7RI@28221|Deltaproteobacteria,43VYJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Phosphoribosyl-AMP cyclohydrolase	hisI	-	3.5.4.19,3.6.1.31	ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
k59_571908_1	1411123.JQNH01000001_gene492	4.87e-24	99.8	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2TT1U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	GO:0003674,GO:0003824,GO:0004733,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
k59_220258_2	187272.Mlg_1992	7.22e-70	213.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,1WYRV@135613|Chromatiales	135613|Chromatiales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
k59_1569730_1	1121405.dsmv_1839	7.02e-37	132.0	COG0517@1|root,COG2204@1|root,COG0517@2|Bacteria,COG2204@2|Bacteria,1NMVW@1224|Proteobacteria,42N24@68525|delta/epsilon subdivisions,2WIQ6@28221|Deltaproteobacteria,2MJ9K@213118|Desulfobacterales	28221|Deltaproteobacteria	T	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Response_reg
k59_1393740_1	1177154.Y5S_02154	0.000559	47.0	COG0834@1|root,COG2206@1|root,COG0834@2|Bacteria,COG2206@2|Bacteria,1MV37@1224|Proteobacteria,1RM9C@1236|Gammaproteobacteria,1XN3B@135619|Oceanospirillales	135619|Oceanospirillales	ET	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5,SBP_bac_3
k59_1038116_1	1304865.JAGF01000001_gene622	8.94e-39	139.0	COG3642@1|root,COG3642@2|Bacteria,2GIX0@201174|Actinobacteria,4F13Z@85016|Cellulomonadaceae	201174|Actinobacteria	T	Domain of unknown function (DUF4032)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4032,Kdo
k59_1038116_2	944560.HMPREF9058_0550	2.69e-42	150.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4D3P8@85005|Actinomycetales	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	ugpC	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
k59_1627833_1	323850.Shew_0020	2.11e-67	220.0	COG0006@1|root,COG0006@2|Bacteria,1MURT@1224|Proteobacteria,1RMKT@1236|Gammaproteobacteria,2Q948@267890|Shewanellaceae	1236|Gammaproteobacteria	E	Splits dipeptides with a prolyl residue in the C- terminal position	pepQ	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009056,GO:0009987,GO:0016787,GO:0016805,GO:0019538,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0070573,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_799359_2	765910.MARPU_13720	1.36e-29	110.0	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,1S2ZH@1236|Gammaproteobacteria,1WXZY@135613|Chromatiales	135613|Chromatiales	S	Sulfur oxidation protein SoxY	-	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY
k59_1038121_1	1095767.CAHD01000136_gene2298	6.84e-169	485.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2GM09@201174|Actinobacteria,4F12B@85016|Cellulomonadaceae	201174|Actinobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_1454088_1	243233.MCA3060	6.35e-50	168.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1XDQQ@135618|Methylococcales	135618|Methylococcales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
k59_1454088_2	1249627.D779_0912	5.63e-39	132.0	COG3118@1|root,COG3118@2|Bacteria,1RI6E@1224|Proteobacteria,1S8B4@1236|Gammaproteobacteria,1WYJW@135613|Chromatiales	135613|Chromatiales	O	Belongs to the thioredoxin family	-	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	Thioredoxin
k59_1111702_2	440512.C211_10730	2.23e-11	60.8	COG2841@1|root,COG2841@2|Bacteria,1NGDM@1224|Proteobacteria,1SGT6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09794	-	-	-	-	ko00000	-	-	-	DUF465
k59_338374_1	1207063.P24_16892	1.13e-36	147.0	COG2982@1|root,COG2982@2|Bacteria,1MUAN@1224|Proteobacteria,2U26R@28211|Alphaproteobacteria,2JPQ3@204441|Rhodospirillales	204441|Rhodospirillales	M	AsmA family	-	-	-	ko:K07289,ko:K07290	-	-	-	-	ko00000	9.B.121	-	-	AsmA,AsmA_2
k59_630963_1	933262.AXAM01000010_gene1385	9.36e-48	162.0	COG0711@1|root,COG0711@2|Bacteria,1N97K@1224|Proteobacteria,42VYP@68525|delta/epsilon subdivisions,2WR6T@28221|Deltaproteobacteria,2MK1E@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
k59_1520567_1	1121459.AQXE01000012_gene2349	2.92e-14	70.5	COG2945@1|root,COG2945@2|Bacteria,1QY8I@1224|Proteobacteria,43CAB@68525|delta/epsilon subdivisions,2X7KV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1454102_1	1313421.JHBV01000014_gene3891	0.000148	50.4	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,OMP_b-brl_3,Plug
k59_690192_1	497964.CfE428DRAFT_5662	5.03e-37	145.0	COG0249@1|root,COG0249@2|Bacteria,46SCK@74201|Verrucomicrobia	74201|Verrucomicrobia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_162100_1	472759.Nhal_3534	5.92e-180	519.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1WXKA@135613|Chromatiales	135613|Chromatiales	G	PFAM Alpha amylase, catalytic	-	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_690202_1	765913.ThidrDRAFT_3478	6.77e-47	175.0	COG1196@1|root,COG1196@2|Bacteria,1R4SX@1224|Proteobacteria,1RVI9@1236|Gammaproteobacteria,1WVYM@135613|Chromatiales	135613|Chromatiales	A	Domain of Unknown Function (DUF349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF349
k59_1801406_1	460265.Mnod_6193	2.2e-27	114.0	COG0642@1|root,COG2205@2|Bacteria,1QTVU@1224|Proteobacteria,2TW3R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	2CSK_N,HATPase_c
k59_1627894_1	1445613.JALM01000081_gene1016	6.32e-19	90.5	COG0154@1|root,COG0154@2|Bacteria,2I9DH@201174|Actinobacteria,4E9Q5@85010|Pseudonocardiales	201174|Actinobacteria	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
k59_571982_1	1391646.AVSU01000057_gene1207	1.11e-33	132.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,25QHI@186804|Peptostreptococcaceae	186801|Clostridia	G	Pyruvate kinase	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
k59_338397_2	247156.NFA_7770	1.14e-34	118.0	COG0199@1|root,COG0199@2|Bacteria,2IQ8R@201174|Actinobacteria,4G30T@85025|Nocardiaceae	201174|Actinobacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
k59_338397_3	367299.JOEE01000001_gene2188	7.33e-55	173.0	COG0096@1|root,COG0096@2|Bacteria,2IHQZ@201174|Actinobacteria,4FGBW@85021|Intrasporangiaceae	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
k59_1756457_1	1042377.AFPJ01000014_gene1680	6.16e-73	231.0	COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria,466B8@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	DNA polymerase III, delta subunit	holA	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delt_C,DNA_pol3_delta
k59_1230837_1	1463879.JOHP01000029_gene4919	3.04e-30	118.0	2BWNB@1|root,32WFI@2|Bacteria,2IAXT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_879402_1	706587.Desti_2454	4.86e-89	273.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MQ86@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Acyl-CoA dehydrogenase	-	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0036094,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0048037,GO:0050660,GO:0050662,GO:0051259,GO:0051262,GO:0052890,GO:0055114,GO:0065003,GO:0071840,GO:0097159,GO:1901265,GO:1901363	1.3.8.10,1.3.8.11	ko:K19066,ko:K19067	ko00362,ko01120,map00362,map01120	-	R09252,R10601	RC00248,RC02035	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_3306	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_349109_1	863365.XHC_1294	1.84e-81	264.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1X4Q2@135614|Xanthomonadales	135614|Xanthomonadales	S	transporter	oliA	-	-	-	-	-	-	-	-	-	-	-	OPT
k59_1813923_1	1123242.JH636435_gene1916	3.22e-38	142.0	COG2230@1|root,COG2230@2|Bacteria,2IYIJ@203682|Planctomycetes	203682|Planctomycetes	M	COG2230 Cyclopropane fatty acid synthase and related	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_1813923_2	1205908.AKXW01000004_gene3088	2.23e-05	46.6	COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,1RRT8@1236|Gammaproteobacteria,1XW4E@135623|Vibrionales	135623|Vibrionales	S	Protein of unknown function (DUF1365)	-	-	-	ko:K09701	-	-	-	-	ko00000	-	-	-	DUF1365
k59_703060_1	593907.Celgi_1840	4.57e-22	98.2	COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria,4F0IV@85016|Cellulomonadaceae	201174|Actinobacteria	O	PFAM AAA ATPase central domain protein	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
k59_642741_1	553385.JEMF01000123_gene284	3.61e-54	189.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,1RP55@1236|Gammaproteobacteria,1XI4T@135619|Oceanospirillales	135619|Oceanospirillales	P	iron ABC transporter permease	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_1168056_1	1203554.HMPREF1476_02322	1.53e-29	117.0	COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,2VJX1@28216|Betaproteobacteria,4PQ95@995019|Sutterellaceae	28216|Betaproteobacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_523688_1	1032480.MLP_44240	3.7e-13	77.0	COG2801@1|root,COG3415@1|root,COG2801@2|Bacteria,COG3415@2|Bacteria,2GP8B@201174|Actinobacteria	201174|Actinobacteria	L	Transposition protein	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_23,HTH_28,HTH_29,Mu-transpos_C,rve
k59_1758470_1	1249627.D779_1950	1.14e-58	201.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1WVWQ@135613|Chromatiales	135613|Chromatiales	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C
k59_234127_1	1123368.AUIS01000003_gene1581	6.18e-82	256.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,2NC36@225057|Acidithiobacillales	225057|Acidithiobacillales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_234128_1	1049564.TevJSym_af00910	7.87e-90	273.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1J4F3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_642766_1	1353537.TP2_13825	3.88e-93	287.0	COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,2TRVM@28211|Alphaproteobacteria,2XNUB@285107|Thioclava	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF839)	-	-	-	ko:K07093	-	-	-	-	ko00000	-	-	-	DUF839
k59_1466473_1	1122135.KB893134_gene3606	2.94e-91	284.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2TR3H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_1168095_1	1499967.BAYZ01000095_gene4283	8.07e-144	417.0	COG1473@1|root,COG1473@2|Bacteria,2NQJY@2323|unclassified Bacteria	2|Bacteria	E	Peptidase dimerisation domain	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_234137_1	1209072.ALBT01000066_gene1107	4.15e-94	304.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,1FGZ5@10|Cellvibrio	1236|Gammaproteobacteria	E	Putative amidoligase enzyme (DUF2126)	IV02_11925	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
k59_467893_1	1123393.KB891327_gene428	7.48e-41	154.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1KSPT@119069|Hydrogenophilales	119069|Hydrogenophilales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,Response_reg
k59_1813993_1	371731.Rsw2DRAFT_2397	1.19e-08	54.3	COG1321@1|root,COG1321@2|Bacteria,1RH2Z@1224|Proteobacteria,2UA17@28211|Alphaproteobacteria,1FCS2@1060|Rhodobacter	28211|Alphaproteobacteria	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	ko:K11924	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress
k59_1813993_2	371731.Rsw2DRAFT_2396	1.06e-73	234.0	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,2TUTC@28211|Alphaproteobacteria,1FCCH@1060|Rhodobacter	28211|Alphaproteobacteria	P	H( )-stimulated, divalent metal cation uptake system	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
k59_1640996_1	543728.Vapar_0262	6.82e-84	260.0	COG0304@1|root,COG0304@2|Bacteria,1N91E@1224|Proteobacteria,2VJR3@28216|Betaproteobacteria,4ACEW@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabB	-	2.3.1.179,2.3.1.41	ko:K00647,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1813999_1	926569.ANT_18990	1.88e-28	109.0	COG0250@1|root,COG0250@2|Bacteria,2G6A3@200795|Chloroflexi	200795|Chloroflexi	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
k59_1813999_2	1293054.HSACCH_00906	0.000614	40.4	COG0690@1|root,COG0690@2|Bacteria,1VK48@1239|Firmicutes,24UI4@186801|Clostridia,3WAYQ@53433|Halanaerobiales	186801|Clostridia	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
k59_1407249_2	1122185.N792_04920	5.1e-54	176.0	COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,1S3TQ@1236|Gammaproteobacteria,1X6HJ@135614|Xanthomonadales	135614|Xanthomonadales	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_467931_1	66373.JOFQ01000003_gene5724	6.65e-73	235.0	COG2303@1|root,COG2303@2|Bacteria,2I5YA@201174|Actinobacteria	201174|Actinobacteria	E	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N
k59_1758514_2	1232437.KL661988_gene118	8.95e-33	122.0	COG1648@1|root,COG1648@2|Bacteria,1RB3H@1224|Proteobacteria,42QT2@68525|delta/epsilon subdivisions,2WN1F@28221|Deltaproteobacteria,2MJPS@213118|Desulfobacterales	28221|Deltaproteobacteria	H	TIGRFAM siroheme synthase	cysG	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_M
k59_1583938_1	1267005.KB911260_gene3517	7.61e-114	353.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,3N68D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1168152_1	1089552.KI911559_gene3172	2.04e-87	266.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS4J@28211|Alphaproteobacteria,2JQS9@204441|Rhodospirillales	204441|Rhodospirillales	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_351507_1	573413.Spirs_0345	9.39e-101	304.0	COG4177@1|root,COG4177@2|Bacteria,2J7RK@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_583464_1	1399115.U719_05130	6.07e-05	50.4	COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2208@2|Bacteria,1TS3B@1239|Firmicutes,4HCRR@91061|Bacilli	91061|Bacilli	T	response regulator	rsbU	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
k59_523755_1	1123354.AUDR01000013_gene656	1.13e-39	145.0	COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2VIAV@28216|Betaproteobacteria,1KS5M@119069|Hydrogenophilales	119069|Hydrogenophilales	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
k59_810270_1	371731.Rsw2DRAFT_1386	1.93e-30	118.0	COG0697@1|root,COG0697@2|Bacteria,1RFZW@1224|Proteobacteria,2TRXD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_351510_1	1236501.BAJU01000104_gene3338	5.2e-08	54.3	COG0811@1|root,COG0811@2|Bacteria,1NMPB@1224|Proteobacteria,2TVM9@28211|Alphaproteobacteria,2JRH9@204441|Rhodospirillales	204441|Rhodospirillales	U	TonB dependent biopolymer transporter integral cytoplasmic membrane subunit, working with ExbD	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_351510_2	1234595.C725_2014	7.74e-07	55.8	COG0810@1|root,COG0810@2|Bacteria,1RCAG@1224|Proteobacteria,2U664@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Periplasmic protein TonB, links inner and outer membranes	tonB	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
k59_351510_3	794903.OPIT5_03680	2.93e-11	63.5	COG0129@1|root,COG0129@2|Bacteria,46SBY@74201|Verrucomicrobia,3K7M4@414999|Opitutae	414999|Opitutae	EG	Dehydratase family	-	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_703156_1	1118235.CAJH01000027_gene1930	1.24e-22	102.0	COG4206@1|root,COG4206@2|Bacteria,1MUZG@1224|Proteobacteria,1RP7I@1236|Gammaproteobacteria,1X3BA@135614|Xanthomonadales	135614|Xanthomonadales	H	Outer membrane receptor proteins mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1814071_1	926549.KI421517_gene2255	3.07e-33	132.0	COG0526@1|root,COG3391@1|root,COG0526@2|Bacteria,COG3391@2|Bacteria,4NK8G@976|Bacteroidetes,47N27@768503|Cytophagia	976|Bacteroidetes	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Thioredoxin_8
k59_642842_1	765911.Thivi_3596	1.67e-92	276.0	COG2941@1|root,COG2941@2|Bacteria,1RAA1@1224|Proteobacteria,1RPMV@1236|Gammaproteobacteria,1WWM4@135613|Chromatiales	135613|Chromatiales	H	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol	coq7	-	-	ko:K06134	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00128	R04984,R08775	RC01254	ko00000,ko00001,ko00002,ko01000	-	-	-	COQ7
k59_1056356_1	367299.JOEE01000001_gene2206	6.55e-86	261.0	COG0202@1|root,COG0202@2|Bacteria,2GJJ5@201174|Actinobacteria,4FF7C@85021|Intrasporangiaceae	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_1056357_1	1267005.KB911255_gene2995	2.57e-80	253.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TR1W@28211|Alphaproteobacteria,3N6IU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	FP	Ppx/GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_1056362_1	225937.HP15_277	2.93e-80	256.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,464ZX@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	ATPase with chaperone activity	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_1407308_1	525246.HMPREF0058_2228	2.76e-23	102.0	COG0739@1|root,COG0739@2|Bacteria,2GM7Q@201174|Actinobacteria,4D81C@85005|Actinomycetales	201174|Actinobacteria	M	Peptidase, M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_523797_1	765911.Thivi_1256	4.56e-11	59.3	2ES8A@1|root,33JSY@2|Bacteria,1NHTH@1224|Proteobacteria,1SHN8@1236|Gammaproteobacteria,1WZPR@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_468025_1	1267535.KB906767_gene1214	3.41e-26	110.0	COG2433@1|root,COG2433@2|Bacteria,3Y7F1@57723|Acidobacteria	57723|Acidobacteria	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
k59_1407324_2	590998.Celf_1919	6.19e-41	145.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,2GMFH@201174|Actinobacteria	201174|Actinobacteria	E	PHP domain	polX	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	HHH_8,PHP
k59_1814138_1	1121385.AQXW01000004_gene2310	5.34e-10	63.9	COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria,1ZW37@145357|Dermacoccaceae	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
k59_703214_1	395493.BegalDRAFT_2688	1.34e-71	246.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,462AI@72273|Thiotrichales	72273|Thiotrichales	P	PFAM von Willebrand factor type A domain	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	-
k59_351578_1	439235.Dalk_2844	2.31e-47	171.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2MI3D@213118|Desulfobacterales	28221|Deltaproteobacteria	L	UvrD REP helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1056407_1	1335757.SPICUR_07745	1.24e-139	407.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1WXB6@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_1056407_2	1541065.JRFE01000008_gene5026	1.86e-21	87.0	COG0271@1|root,COG0271@2|Bacteria,1G7V3@1117|Cyanobacteria,3VKKH@52604|Pleurocapsales	1117|Cyanobacteria	T	BolA-like protein	colA	-	-	-	-	-	-	-	-	-	-	-	BolA
k59_642900_1	472759.Nhal_2749	1.77e-45	152.0	COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,1RNSJ@1236|Gammaproteobacteria,1WY08@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4_21
k59_642900_2	713587.THITH_04385	2.69e-57	182.0	COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,1WX8K@135613|Chromatiales	135613|Chromatiales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
k59_523851_1	521393.JH806634_gene2336	3.07e-90	281.0	COG5421@1|root,COG5421@2|Bacteria,2GK2A@201174|Actinobacteria,4D4NA@85005|Actinomycetales	201174|Actinobacteria	L	An automated process has identified a potential problem with this gene model	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_642903_1	335543.Sfum_0314	3.42e-116	343.0	COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,42PN2@68525|delta/epsilon subdivisions,2WM53@28221|Deltaproteobacteria,2MRX0@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_523854_1	1121405.dsmv_0625	1.13e-51	169.0	2ARUS@1|root,31H6C@2|Bacteria,1RFAK@1224|Proteobacteria,42SPB@68525|delta/epsilon subdivisions,2WPJK@28221|Deltaproteobacteria,2MKD1@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Type I restriction enzyme R protein N terminus (HSDR_N)	-	-	-	-	-	-	-	-	-	-	-	-	HSDR_N_2
k59_1466591_1	439235.Dalk_2268	4.28e-43	157.0	COG4191@1|root,COG4191@2|Bacteria,1R682@1224|Proteobacteria,42P91@68525|delta/epsilon subdivisions,2WKQI@28221|Deltaproteobacteria,2MJEK@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9
k59_1168293_1	1249627.D779_0331	3.79e-142	413.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,1WWG7@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_1814187_1	83406.HDN1F_29010	1.1e-130	411.0	COG0433@1|root,COG0433@2|Bacteria,1NAXG@1224|Proteobacteria,1SJQR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	3'(2'),5'-bisphosphate nucleotidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Inovirus_Gp2
k59_1814187_2	83406.HDN1F_29020	1.34e-22	95.5	2CBBK@1|root,2ZADC@2|Bacteria,1R4ED@1224|Proteobacteria,1RS9S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_583543_1	935839.JAGJ01000011_gene426	4.09e-56	190.0	COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria,4F51G@85017|Promicromonosporaceae	201174|Actinobacteria	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_1814199_1	671143.DAMO_1522	2.05e-51	174.0	COG2267@1|root,COG2267@2|Bacteria,2NPTF@2323|unclassified Bacteria	2|Bacteria	I	Alpha/beta hydrolase family	mhpC	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
k59_1168315_1	324602.Caur_3417	0.000343	45.4	COG0805@1|root,COG0805@2|Bacteria,2G6SP@200795|Chloroflexi,375NQ@32061|Chloroflexia	32061|Chloroflexia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_1168315_2	1445613.JALM01000016_gene6077	2.35e-10	59.7	COG1826@1|root,COG1826@2|Bacteria,2GQQX@201174|Actinobacteria,4E7RK@85010|Pseudonocardiales	201174|Actinobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	GO:0008150,GO:0040007	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_703268_1	768671.ThimaDRAFT_2230	5.94e-88	279.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RR5Z@1236|Gammaproteobacteria,1WXE4@135613|Chromatiales	135613|Chromatiales	J	Allophanate hydrolase	-	-	3.5.1.54	ko:K01457	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120	-	R00005	RC02756	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_234328_2	1267005.KB911255_gene2513	1.35e-111	340.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TT3Z@28211|Alphaproteobacteria,3N6MB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Peptidase M23	MA20_20375	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1056512_1	768671.ThimaDRAFT_0819	5.37e-58	189.0	COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,1RREE@1236|Gammaproteobacteria,1WWMU@135613|Chromatiales	135613|Chromatiales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1056512_2	156889.Mmc1_0048	1.88e-16	75.5	COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,2U9K5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	DsrC like protein	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_583578_1	395493.BegalDRAFT_0118	4.61e-59	202.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,461PA@72273|Thiotrichales	72273|Thiotrichales	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_1584059_2	1254432.SCE1572_22030	7.77e-05	47.8	COG0515@1|root,COG0745@1|root,COG3266@1|root,COG0515@2|Bacteria,COG0745@2|Bacteria,COG3266@2|Bacteria,1NVZF@1224|Proteobacteria,42ZUK@68525|delta/epsilon subdivisions,2X7NR@28221|Deltaproteobacteria,2Z3H7@29|Myxococcales	28221|Deltaproteobacteria	T	Domain of unknown function (DUF4388)	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF4388,Response_reg
k59_810385_1	395493.BegalDRAFT_0739	6.47e-23	102.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,4604X@72273|Thiotrichales	72273|Thiotrichales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
k59_1407402_1	1410612.JNKO01000014_gene784	4.37e-09	55.8	COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,247ZR@186801|Clostridia,2PQPI@265975|Oribacterium	186801|Clostridia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_1407402_2	511995.CFPG_285	6.15e-37	129.0	COG0103@1|root,COG0103@2|Bacteria,4NNN1@976|Bacteroidetes,2FSGZ@200643|Bacteroidia	976|Bacteroidetes	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
k59_1056522_1	105559.Nwat_0670	8.38e-64	213.0	COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,1RNF3@1236|Gammaproteobacteria,1WWVY@135613|Chromatiales	135613|Chromatiales	T	PFAM MucB RseB	-	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	MucB_RseB,MucB_RseB_C
k59_468190_1	909663.KI867150_gene1794	1.05e-34	135.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2MQD2@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1814276_1	388051.AUFE01000008_gene1694	8.92e-21	96.3	COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,2VMBE@28216|Betaproteobacteria,1K513@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_6,Fer4_7
k59_1814280_1	935866.JAER01000038_gene4169	4.91e-85	280.0	COG5013@1|root,COG5013@2|Bacteria,2GKZU@201174|Actinobacteria,4DNS8@85009|Propionibacteriales	201174|Actinobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	narG	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding
k59_1056552_1	596151.DesfrDRAFT_2468	6.3e-88	269.0	COG4974@1|root,COG4974@2|Bacteria,1NY1A@1224|Proteobacteria,42NX3@68525|delta/epsilon subdivisions,2WME4@28221|Deltaproteobacteria,2M98A@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_468218_1	1117108.PAALTS15_02202	1.74e-70	228.0	COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,4H9P8@91061|Bacilli,26QKI@186822|Paenibacillaceae	91061|Bacilli	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	GO:0000003,GO:0000160,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0019954,GO:0023052,GO:0030436,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035556,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043934,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
k59_586298_2	768671.ThimaDRAFT_0912	5.93e-48	168.0	COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,1RQ8F@1236|Gammaproteobacteria,1X14E@135613|Chromatiales	135613|Chromatiales	P	Periplasmic copper-binding protein (NosD)	-	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
k59_1830062_1	1713.JOFV01000007_gene2975	3.09e-96	308.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4F0QU@85016|Cellulomonadaceae	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
k59_1064764_1	153721.MYP_3868	5.91e-45	164.0	COG3507@1|root,COG4677@1|root,COG3507@2|Bacteria,COG4677@2|Bacteria,4NITR@976|Bacteroidetes	976|Bacteroidetes	G	Pectinesterase	-	-	-	-	-	-	-	-	-	-	-	-	Mfa_like_1,Pectinesterase
k59_1416174_1	1122194.AUHU01000015_gene3021	1.87e-63	201.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,466HT@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036220,GO:0036222,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046983,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	iEC55989_1330.EC55989_3247,iECO111_1330.ECO111_3702,iECSE_1348.ECSE_3222,iECW_1372.ECW_m3212,iEKO11_1354.EKO11_0774,iEcE24377_1341.EcE24377A_3298,iWFL_1372.ECW_m3212	Ham1p_like
k59_890804_1	1158146.KB907122_gene434	5.6e-40	139.0	COG5615@1|root,COG5615@2|Bacteria,1RH6D@1224|Proteobacteria,1S6S2@1236|Gammaproteobacteria,1WZE3@135613|Chromatiales	135613|Chromatiales	S	Copper resistance protein D	-	-	-	-	-	-	-	-	-	-	-	-	CopD
k59_890804_2	1348114.OM33_13380	6.09e-20	81.3	COG2975@1|root,COG2975@2|Bacteria,1N7C1@1224|Proteobacteria,1SC9F@1236|Gammaproteobacteria,2Q3IZ@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Iron-sulphur cluster assembly	iscX	GO:0003674,GO:0004857,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0030234,GO:0031163,GO:0043086,GO:0043167,GO:0043169,GO:0044085,GO:0044092,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050790,GO:0051186,GO:0065007,GO:0065009,GO:0071840,GO:0098772	-	-	-	-	-	-	-	-	-	-	Fe-S_assembly
k59_244542_1	946077.W5A_05113	4.93e-136	417.0	COG5549@1|root,COG5549@2|Bacteria,4NEA0@976|Bacteroidetes,1HWUW@117743|Flavobacteriia	976|Bacteroidetes	O	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
k59_652808_1	1121438.JNJA01000008_gene3982	6.79e-108	328.0	COG2204@1|root,COG2204@2|Bacteria,1MVWX@1224|Proteobacteria,42MIB@68525|delta/epsilon subdivisions,2WJQK@28221|Deltaproteobacteria,2M80M@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Sigma54_activat
k59_1301952_1	765911.Thivi_3570	8.28e-80	247.0	COG2227@1|root,COG2227@2|Bacteria,1NN3B@1224|Proteobacteria,1T1TQ@1236|Gammaproteobacteria,1WX2V@135613|Chromatiales	135613|Chromatiales	J	Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs	cmoB	-	-	ko:K15257	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_9
k59_300552_1	292415.Tbd_1536	6.91e-63	200.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2VJ5G@28216|Betaproteobacteria,1KRK3@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
k59_69078_1	1049564.TevJSym_ah00930	3.46e-83	253.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,1RS6A@1236|Gammaproteobacteria,1J7ZS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Thiosulfate-oxidizing multienzyme system protein SoxA	soxA	-	1.8.2.2	ko:K17222,ko:K19713	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	-	-	-	-
k59_69078_3	977880.RALTA_A3016	1.51e-29	117.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2VJTS@28216|Betaproteobacteria,1K2Y9@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K11751,ko:K17224	ko00230,ko00240,ko00760,ko00920,ko01100,ko01110,ko01120,map00230,map00240,map00760,map00920,map01100,map01110,map01120	M00595	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R10151	RC00017,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	-	-	-	5_nucleotid_C
k59_828661_1	1122933.JNIY01000003_gene653	2.48e-49	165.0	COG0024@1|root,COG0024@2|Bacteria,2GKKB@201174|Actinobacteria,4F0VK@85016|Cellulomonadaceae	201174|Actinobacteria	J	TIGRFAM methionine aminopeptidase, type I	mapA	GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016020,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901605	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_769064_2	857087.Metme_3943	4.23e-32	122.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1XDXR@135618|Methylococcales	135618|Methylococcales	J	PFAM Aminoacyl-tRNA synthetase, class II (G H P S), conserved region	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_10823_1	1150399.AQYK01000002_gene3302	3.1e-30	115.0	COG3173@1|root,COG3173@2|Bacteria,2GKUU@201174|Actinobacteria,4FNDU@85023|Microbacteriaceae	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_476562_1	420662.Mpe_A1272	7.27e-100	299.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,2VIJV@28216|Betaproteobacteria,1KIUZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_828662_1	999541.bgla_1g37600	7.68e-25	102.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VQ9H@28216|Betaproteobacteria,1K0W8@119060|Burkholderiaceae	28216|Betaproteobacteria	K	regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_244579_1	1121875.KB907550_gene636	8.94e-86	272.0	COG2015@1|root,COG2015@2|Bacteria,4NJE2@976|Bacteroidetes	976|Bacteroidetes	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_244579_2	1249627.D779_4053	5.82e-151	428.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,1S22U@1236|Gammaproteobacteria,1X0RX@135613|Chromatiales	135613|Chromatiales	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_890832_1	443152.MDG893_08871	2.18e-151	446.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,4645B@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_1475773_1	322710.Avin_13080	2e-32	121.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
k59_1475773_2	2340.JV46_24120	1.75e-32	118.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria,1J56A@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	COG0625 Glutathione S-transferase	sspA	GO:0001000,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0008150,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0042594,GO:0043175,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03599	-	-	-	-	ko00000,ko02000,ko03021	1.A.12.3.1	-	-	GST_C,GST_N,GST_N_3
k59_535393_1	926550.CLDAP_14720	2.12e-50	178.0	COG0322@1|root,COG0322@2|Bacteria,2G651@200795|Chloroflexi	200795|Chloroflexi	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_828668_2	243924.LT42_16350	1.01e-42	145.0	COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,1S94K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA polymerase III chi subunit	holC	GO:0005575,GO:0005622,GO:0005623,GO:0006275,GO:0008150,GO:0009314,GO:0009360,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010556,GO:0010557,GO:0010604,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032298,GO:0032991,GO:0042575,GO:0043846,GO:0043847,GO:0044424,GO:0044464,GO:0045740,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051173,GO:0060255,GO:0061695,GO:0065007,GO:0080090,GO:0090329,GO:1902494,GO:1990234,GO:2000105,GO:2000112	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
k59_828668_3	1217705.F900_03011	3.32e-05	45.4	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,3NJ24@468|Moraxellaceae	1236|Gammaproteobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_69099_1	1267005.KB911255_gene2458	2.74e-74	249.0	COG3206@1|root,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	-
k59_1533010_1	1173020.Cha6605_4495	1.11e-76	244.0	COG5659@1|root,COG5659@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_890839_1	864069.MicloDRAFT_00046900	4.69e-41	150.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,1JTC7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1475778_1	288000.BBta_7817	6.76e-35	120.0	COG3293@1|root,COG3293@2|Bacteria,1QWUV@1224|Proteobacteria,2TX63@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2
k59_1475778_2	288000.BBta_7818	6.03e-65	201.0	COG3293@1|root,COG3293@2|Bacteria,1RDDI@1224|Proteobacteria,2UAE0@28211|Alphaproteobacteria,3K60B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DUF4096
k59_244588_1	1249627.D779_2931	7.26e-37	129.0	COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria,1SA44@1236|Gammaproteobacteria,1X24M@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_244588_2	1223545.GS4_04_00340	2.69e-38	131.0	COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria,4GEGG@85026|Gordoniaceae	201174|Actinobacteria	O	Thioredoxin-like domain	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_949799_1	644282.Deba_2537	2.37e-141	426.0	COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,42M86@68525|delta/epsilon subdivisions,2WIT1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Subunit R is required for both nuclease and ATPase activities, but not for modification	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HSDR_N,ResIII
k59_183203_1	936548.HMPREF1136_1734	1.95e-06	48.5	COG1825@1|root,COG1825@2|Bacteria,2GJPJ@201174|Actinobacteria,4D4B1@85005|Actinomycetales	201174|Actinobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_183203_2	768671.ThimaDRAFT_0287	8.46e-97	290.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1WWSB@135613|Chromatiales	135613|Chromatiales	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_652841_1	243231.GSU2691	5.89e-60	200.0	COG2267@1|root,COG2267@2|Bacteria,1MX2H@1224|Proteobacteria,42MNT@68525|delta/epsilon subdivisions,2WJZS@28221|Deltaproteobacteria,43SWW@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1709862_1	66692.ABC0508	9.69e-47	161.0	COG0451@1|root,COG0451@2|Bacteria,1V34Y@1239|Firmicutes,4HCJE@91061|Bacilli,1ZD5U@1386|Bacillus	91061|Bacilli	M	GDP-mannose 4,6 dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_1709862_2	519989.ECTPHS_03929	3.91e-17	79.3	COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,1RQ7W@1236|Gammaproteobacteria,1X286@135613|Chromatiales	135613|Chromatiales	C	Oxidoreductase FAD-binding domain	-	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind
k59_301266_1	1385518.N798_08805	2.38e-56	186.0	COG2816@1|root,COG2816@2|Bacteria,2GJZY@201174|Actinobacteria,4FFWB@85021|Intrasporangiaceae	201174|Actinobacteria	L	Nudix hydrolase	nudC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
k59_184002_1	103690.17134509	1.9e-44	152.0	COG0500@1|root,COG2226@2|Bacteria,1G0GS@1117|Cyanobacteria,1HM74@1161|Nostocales	1117|Cyanobacteria	Q	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_891812_1	631362.Thi970DRAFT_03699	3.38e-161	465.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1WWGZ@135613|Chromatiales	135613|Chromatiales	J	PFAM tRNA synthetase class II (G H P and S)	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_950813_2	1317118.ATO8_10438	1.79e-18	86.7	COG4725@1|root,COG4725@2|Bacteria,1R553@1224|Proteobacteria,2TRP6@28211|Alphaproteobacteria,4KNET@93682|Roseivivax	28211|Alphaproteobacteria	KT	Belongs to the MT-A70-like family	-	-	-	-	-	-	-	-	-	-	-	-	MT-A70
k59_1831133_1	396588.Tgr7_1389	6.62e-91	275.0	COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,1RRT8@1236|Gammaproteobacteria,1WX90@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1365)	-	-	-	ko:K09701	-	-	-	-	ko00000	-	-	-	DUF1365
k59_12361_1	1408445.JHXP01000003_gene992	2.53e-68	227.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1JCH1@118969|Legionellales	118969|Legionellales	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	yfcX	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_594664_1	1122611.KB903939_gene305	1.04e-68	229.0	COG0457@1|root,COG0457@2|Bacteria,2IFW2@201174|Actinobacteria	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_363601_2	670292.JH26_20430	2.11e-42	147.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2TR2V@28211|Alphaproteobacteria,1JTIT@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
k59_1066278_1	240016.ABIZ01000001_gene2354	1.66e-93	291.0	COG0664@1|root,COG2066@1|root,COG0664@2|Bacteria,COG2066@2|Bacteria,46USD@74201|Verrucomicrobia,2ITM7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	ET	Glutaminase	-	-	-	-	-	-	-	-	-	-	-	-	Glutaminase,cNMP_binding
k59_1533765_2	1278073.MYSTI_04986	6.93e-24	102.0	COG4942@1|root,COG4942@2|Bacteria,1MXRZ@1224|Proteobacteria,42M6D@68525|delta/epsilon subdivisions,2WM2J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Protein of unknown function (DUF3375)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3375
k59_12380_1	617140.AJZE01000057_gene2121	7.33e-17	83.2	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1XU6J@135623|Vibrionales	135623|Vibrionales	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	ubiF	-	-	ko:K03184	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R06146,R08775	RC01254	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FAD_binding_3,SE
k59_12380_2	1282876.BAOK01000002_gene226	1.11e-62	211.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2TRZU@28211|Alphaproteobacteria,4BQ2I@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	CH	FAD binding domain	ubiH	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_653605_2	1005395.CSV86_19028	9.83e-05	48.9	2E9FY@1|root,333P7@2|Bacteria,1N8S6@1224|Proteobacteria,1S77C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_70132_1	1095772.CAHH01000072_gene493	6.71e-19	81.6	COG0545@1|root,COG0545@2|Bacteria,2GJK2@201174|Actinobacteria	201174|Actinobacteria	O	Peptidyl-prolyl cis-trans isomerase	fkbP	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
k59_70132_2	2074.JNYD01000020_gene2700	2.23e-29	107.0	2B64X@1|root,31Z1U@2|Bacteria,2H1JT@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4332
k59_1651887_2	471853.Bcav_2017	2.55e-27	108.0	COG0169@1|root,COG0169@2|Bacteria,2GPQQ@201174|Actinobacteria	201174|Actinobacteria	E	Shikimate dehydrogenase	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2552c	Shikimate_DH,Shikimate_dh_N
k59_829518_1	1283284.AZUK01000001_gene2456	9.22e-64	201.0	COG0634@1|root,COG0634@2|Bacteria	2|Bacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_246117_1	670307.HYPDE_35973	3.49e-168	500.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2TQSP@28211|Alphaproteobacteria,3N6CN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_1651891_1	1121405.dsmv_3751	5.73e-107	334.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria,2MI13@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_891848_1	1148.1001647	8.04e-85	276.0	COG0475@1|root,COG0589@1|root,COG0475@2|Bacteria,COG0589@2|Bacteria,1G00D@1117|Cyanobacteria,1H4SF@1142|Synechocystis	1117|Cyanobacteria	P	Sodium/hydrogen exchanger family	nhaS5	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,Usp
k59_70151_1	1403819.BATR01000196_gene6596	4.82e-52	179.0	COG3344@1|root,COG3344@2|Bacteria,46TQ6@74201|Verrucomicrobia	74201|Verrucomicrobia	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_1357831_2	1449976.KALB_3072	9.4e-23	99.8	COG3509@1|root,COG3509@2|Bacteria,2IGF9@201174|Actinobacteria,4E6XS@85010|Pseudonocardiales	201174|Actinobacteria	Q	Esterase PHB depolymerase	lpqC	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Esterase,Esterase_phd
k59_1709889_1	1267005.KB911265_gene3627	8.7e-19	95.5	COG0790@1|root,COG3170@1|root,COG0790@2|Bacteria,COG3170@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,3N6X8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Sel1-like repeats.	-	-	-	ko:K07126,ko:K13582	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	PG_binding_1,Sel1
k59_1476891_1	367299.JOEE01000008_gene439	1.13e-101	315.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,2GJ50@201174|Actinobacteria,4FF41@85021|Intrasporangiaceae	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase	fadB	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_1476891_2	367299.JOEE01000008_gene440	1.04e-103	310.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4FER0@85021|Intrasporangiaceae	201174|Actinobacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_769712_1	631362.Thi970DRAFT_00795	4.35e-98	295.0	arCOG03638@1|root,2Z7NN@2|Bacteria,1R3Y6@1224|Proteobacteria,1RTWY@1236|Gammaproteobacteria,1X2HW@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1538)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1538
k59_1303042_1	713586.KB900536_gene663	1.34e-29	119.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WW5M@135613|Chromatiales	135613|Chromatiales	EH	Anthranilate synthase component I	-	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_653629_1	941449.dsx2_1611	1.35e-17	79.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,42RB9@68525|delta/epsilon subdivisions,2WMPE@28221|Deltaproteobacteria,2MB1R@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	bfr	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
k59_653629_2	387631.Asulf_01274	1.05e-50	164.0	COG1720@1|root,arCOG00761@2157|Archaea,2XY3D@28890|Euryarchaeota,246RS@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
k59_246137_1	998674.ATTE01000001_gene2010	1.61e-39	140.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,1S8R3@1236|Gammaproteobacteria,460FY@72273|Thiotrichales	72273|Thiotrichales	M	PFAM Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_477352_1	1381123.AYOD01000016_gene2749	2.71e-81	256.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2TRFV@28211|Alphaproteobacteria,43IYT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_769714_1	234267.Acid_5155	4.67e-51	181.0	COG1716@1|root,COG3829@1|root,COG1716@2|Bacteria,COG3829@2|Bacteria,3Y6K2@57723|Acidobacteria	57723|Acidobacteria	KT	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat,Yop-YscD_cpl
k59_712378_1	478741.JAFS01000001_gene1289	4.46e-27	106.0	COG0491@1|root,COG0491@2|Bacteria,46S7X@74201|Verrucomicrobia,37GB4@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_712378_2	240016.ABIZ01000001_gene1263	1.84e-11	67.8	COG1266@1|root,COG1266@2|Bacteria,46WKN@74201|Verrucomicrobia,2IUVF@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
k59_1709898_1	292415.Tbd_0706	2.52e-142	414.0	COG3746@1|root,COG3746@2|Bacteria,1QYIH@1224|Proteobacteria	1224|Proteobacteria	P	Phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
k59_246147_1	1100721.ALKO01000003_gene1945	2.29e-11	74.3	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria,4AJ2F@80864|Comamonadaceae	28216|Betaproteobacteria	M	Surface antigen	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k59_363653_1	1469245.JFBG01000036_gene1994	1.19e-42	153.0	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,1WWFE@135613|Chromatiales	135613|Chromatiales	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
k59_950881_2	351016.RAZWK3B_11096	6.44e-51	166.0	COG0735@1|root,COG0735@2|Bacteria,1MZIW@1224|Proteobacteria,2U9G4@28211|Alphaproteobacteria,2P35R@2433|Roseobacter	28211|Alphaproteobacteria	P	COG0735 Fe2 Zn2 uptake regulation proteins	zur	-	-	ko:K09823	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	FUR
k59_594707_1	572477.Alvin_2906	1.72e-69	224.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1WW09@135613|Chromatiales	135613|Chromatiales	CH	Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	-	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_484023_1	519989.ECTPHS_02541	9.94e-111	328.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1WWTH@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
k59_1364509_1	285514.JNWO01000001_gene4097	4.67e-77	243.0	COG1168@1|root,COG1168@2|Bacteria,2GJFQ@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase, class I	patB	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1716398_1	367299.JOEE01000004_gene1165	8.32e-150	436.0	COG0541@1|root,COG0541@2|Bacteria,2GK4R@201174|Actinobacteria,4FEYZ@85021|Intrasporangiaceae	201174|Actinobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_1424148_1	1122933.JNIY01000003_gene971	1.14e-90	280.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,4F10W@85016|Cellulomonadaceae	201174|Actinobacteria	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
k59_23667_1	555079.Toce_1671	9.82e-107	330.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,42F1Y@68295|Thermoanaerobacterales	186801|Clostridia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_1659011_1	1232410.KI421414_gene2883	2.49e-95	300.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2WIZF@28221|Deltaproteobacteria,43SZI@69541|Desulfuromonadales	28221|Deltaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_542846_1	216591.BCAL3240	0.000508	42.7	COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,2VJV6@28216|Betaproteobacteria,1K3K7@119060|Burkholderiaceae	28216|Betaproteobacteria	GM	ABC transporter	kpsT	-	3.6.3.38	ko:K09689	ko02010,map02010	M00249	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.101	-	-	ABC_tran
k59_542846_2	1479237.JMLY01000001_gene750	2.64e-74	234.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,1RMDF@1236|Gammaproteobacteria,465Z0@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	btuC	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
k59_1312539_1	744872.Spica_1884	7.24e-47	171.0	COG0475@1|root,COG1762@1|root,COG0475@2|Bacteria,COG1762@2|Bacteria,2J603@203691|Spirochaetes	203691|Spirochaetes	GPT	PFAM Sodium hydrogen exchanger family	napA-1	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,PTS_EIIA_2
k59_775298_2	1122933.JNIY01000005_gene1698	1.44e-14	73.9	COG0341@1|root,COG0341@2|Bacteria,2GJRS@201174|Actinobacteria,4F0UU@85016|Cellulomonadaceae	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_79567_1	326297.Sama_2803	1.9e-09	62.0	2DNTA@1|root,32Z1C@2|Bacteria,1NCZW@1224|Proteobacteria,1SDTR@1236|Gammaproteobacteria,2QBY6@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
k59_79567_2	396588.Tgr7_0294	3.93e-07	55.1	COG3271@1|root,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,1S2EC@1236|Gammaproteobacteria,1X0UF@135613|Chromatiales	135613|Chromatiales	NU	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2,TPR_16
k59_1077034_1	979556.MTES_1639	1.34e-23	103.0	COG0577@1|root,COG0577@2|Bacteria,2GKF3@201174|Actinobacteria,4FKY1@85023|Microbacteriaceae	201174|Actinobacteria	V	Efflux ABC transporter, permease protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_836466_1	1238184.CM001792_gene1596	2.22e-10	65.9	COG1536@1|root,COG1536@2|Bacteria,1TP01@1239|Firmicutes,4HAFZ@91061|Bacilli,23JIU@182709|Oceanobacillus	91061|Bacilli	N	FliG middle domain	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
k59_23693_1	330214.NIDE1766	4.08e-14	73.9	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cusB	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	DUF3347,HlyD_D23,HlyD_D4
k59_23693_2	1300345.LF41_1741	3.41e-33	127.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1X3MW@135614|Xanthomonadales	135614|Xanthomonadales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
k59_1251370_1	765911.Thivi_4469	1.77e-120	357.0	COG1018@1|root,COG1018@2|Bacteria,1MV41@1224|Proteobacteria,1RMPJ@1236|Gammaproteobacteria,1WZKR@135613|Chromatiales	135613|Chromatiales	C	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress	hmp	-	1.14.12.17	ko:K05916	ko05132,map05132	-	-	-	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2,Globin,NAD_binding_1
k59_960394_1	590998.Celf_2772	3.63e-147	437.0	COG0296@1|root,COG0296@2|Bacteria,2GJ5C@201174|Actinobacteria,4F22N@85016|Cellulomonadaceae	201174|Actinobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0055114,GO:0071704,GO:0071944,GO:1901576	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_1189195_1	880072.Desac_1143	2.76e-79	261.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MQB6@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_901409_1	572477.Alvin_0252	3.62e-69	229.0	COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,1WWRD@135613|Chromatiales	135613|Chromatiales	M	HAD-superfamily hydrolase, subfamily IIB	-	-	2.4.1.14	ko:K00696	ko00500,ko01100,map00500,map01100	-	R00766	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth
k59_960397_1	452863.Achl_1275	1.67e-35	136.0	COG1928@1|root,COG1928@2|Bacteria,2I2H1@201174|Actinobacteria,1W7US@1268|Micrococcaceae	201174|Actinobacteria	O	C-terminal four TMM region of protein-O-mannosyltransferase	pmt	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	PMT,PMT_4TMC
k59_542862_1	1249627.D779_1592	1.9e-67	220.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1WWHC@135613|Chromatiales	135613|Chromatiales	J	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
k59_542862_2	998088.B565_0663	7.26e-49	162.0	COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,1S63J@1236|Gammaproteobacteria,1Y4HB@135624|Aeromonadales	135624|Aeromonadales	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	-	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
k59_542862_3	523791.Kkor_0352	2.05e-87	264.0	COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,1RRXT@1236|Gammaproteobacteria,1XMSX@135619|Oceanospirillales	135619|Oceanospirillales	F	COG1428 Deoxynucleoside kinases	-	-	-	-	-	-	-	-	-	-	-	-	dNK
k59_542862_4	765912.Thimo_3512	6.44e-13	68.2	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,1RM8D@1236|Gammaproteobacteria,1WWMY@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_1312577_1	1157635.KB892042_gene171	8.69e-30	130.0	COG1674@1|root,COG1674@2|Bacteria,2INKZ@201174|Actinobacteria	201174|Actinobacteria	D	ftsk spoiiie	-	-	-	-	-	-	-	-	-	-	-	-	DUF87
k59_1716452_1	675816.VIA_002850	2.63e-14	70.1	COG2020@1|root,COG2020@2|Bacteria,1MZ7S@1224|Proteobacteria,1S8Y4@1236|Gammaproteobacteria,1XX3I@135623|Vibrionales	135623|Vibrionales	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_1312579_1	324925.Ppha_2833	5.99e-51	176.0	COG0318@1|root,COG0318@2|Bacteria,1FDAB@1090|Chlorobi	1090|Chlorobi	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_1189209_1	765911.Thivi_3684	1.09e-11	61.6	COG0790@1|root,COG0790@2|Bacteria,1N293@1224|Proteobacteria,1SBGP@1236|Gammaproteobacteria,1WYX5@135613|Chromatiales	135613|Chromatiales	S	Sel1-like repeats.	-	-	-	-	-	-	-	-	-	-	-	-	Sel1
k59_1189209_2	1178482.BJB45_00375	1.67e-24	102.0	COG0789@1|root,COG0789@2|Bacteria,1R9SN@1224|Proteobacteria,1S967@1236|Gammaproteobacteria,1XMH1@135619|Oceanospirillales	135619|Oceanospirillales	K	Transcriptional	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
k59_1840804_1	644076.SCH4B_0953	3.69e-62	210.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TXAW@28211|Alphaproteobacteria,4NBEB@97050|Ruegeria	28211|Alphaproteobacteria	S	hmm pf01979	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_960419_1	1120998.AUFC01000001_gene1732	7.51e-83	263.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,248G8@186801|Clostridia,3WCE4@538999|Clostridiales incertae sedis	186801|Clostridia	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
k59_542873_1	395493.BegalDRAFT_2379	2.1e-44	154.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,460GY@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
k59_836495_1	1367847.JCM7686_2367	9.71e-40	145.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2TQQV@28211|Alphaproteobacteria,2PWK8@265|Paracoccus	28211|Alphaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_484091_1	478801.Ksed_24100	7.98e-13	68.6	28NWB@1|root,2ZBU7@2|Bacteria,2GJ74@201174|Actinobacteria,1ZW5E@145357|Dermacoccaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3027)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3027
k59_484091_2	471853.Bcav_0848	9.37e-69	209.0	COG1278@1|root,COG1278@2|Bacteria,2IKXN@201174|Actinobacteria	201174|Actinobacteria	K	Cold-shock'	cspB	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_23724_1	1123399.AQVE01000032_gene778	2.26e-100	308.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,1RSCT@1236|Gammaproteobacteria,4624S@72273|Thiotrichales	72273|Thiotrichales	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_1010288_1	1304865.JAGF01000001_gene1359	1.99e-29	117.0	COG1587@1|root,COG1587@2|Bacteria,2GMJZ@201174|Actinobacteria,4F1KG@85016|Cellulomonadaceae	201174|Actinobacteria	H	Uroporphyrinogen-III synthase HemD	hemD	-	2.1.1.107,4.2.1.75	ko:K01719,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
k59_373189_1	871963.Desdi_0250	1.47e-66	214.0	COG5557@1|root,COG5557@2|Bacteria,1UYGM@1239|Firmicutes,24EQA@186801|Clostridia,263KI@186807|Peptococcaceae	186801|Clostridia	C	PFAM Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k59_542877_1	1122622.ATWJ01000014_gene448	1.96e-45	160.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4FG41@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_901450_1	1034943.BN1094_03383	7.04e-91	290.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1JCZ4@118969|Legionellales	118969|Legionellales	I	Domain of unknown function (DUF1974)	fadE_2	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_1540549_1	1267005.KB911255_gene2710	3.39e-19	85.5	COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2U6K4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG0631 Serine threonine protein phosphatase	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
k59_1540549_2	1267005.KB911255_gene2709	3.73e-77	240.0	COG1716@1|root,COG1716@2|Bacteria,1RHU9@1224|Proteobacteria,2UBJ6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG1716 FOG FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
k59_1840822_1	1111131.HMPREF1255_0473	9.27e-06	53.1	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4DNAM@85009|Propionibacteriales	201174|Actinobacteria	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1540550_1	710696.Intca_3339	4.81e-144	420.0	COG2987@1|root,COG2987@2|Bacteria,2GP10@201174|Actinobacteria,4FERC@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
k59_960437_1	1289135.A966_06545	1.23e-80	251.0	COG0216@1|root,COG0216@2|Bacteria,2J5KY@203691|Spirochaetes	203691|Spirochaetes	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_1659075_1	1267005.KB911259_gene3930	1.24e-133	395.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria,3N67T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_1598900_1	743836.AYNA01000054_gene82	3.12e-13	70.9	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,2V487@28211|Alphaproteobacteria,36ZQF@31993|Methylocystaceae	28211|Alphaproteobacteria	CH	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
k59_1598900_2	1255043.TVNIR_2172	3.03e-59	194.0	COG1152@1|root,COG1152@2|Bacteria,1QX31@1224|Proteobacteria,1T35A@1236|Gammaproteobacteria,1X2UN@135613|Chromatiales	135613|Chromatiales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
k59_1364612_1	591157.SSLG_01662	1.12e-78	258.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_775352_1	522306.CAP2UW1_2419	4.85e-76	232.0	2DZXC@1|root,32VMF@2|Bacteria,1N29I@1224|Proteobacteria	1224|Proteobacteria	S	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C92
k59_373226_1	977880.RALTA_A2918	9.72e-98	292.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2VHG6@28216|Betaproteobacteria,1K3PH@119060|Burkholderiaceae	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_1716497_1	1283300.ATXB01000001_gene924	9.76e-43	158.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1XE90@135618|Methylococcales	135618|Methylococcales	O	TIGRFAM SUF system FeS cluster assembly, SufD	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_191155_1	138119.DSY4729	9.43e-40	150.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,24BBE@186801|Clostridia,260K6@186807|Peptococcaceae	186801|Clostridia	C	Fe-S oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8,Nitrate_red_gam
k59_79691_1	716928.AJQT01000017_gene4599	9.12e-28	114.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TYVX@28211|Alphaproteobacteria,4BEIZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0007275,GO:0007399,GO:0008150,GO:0009987,GO:0010975,GO:0016020,GO:0019867,GO:0022008,GO:0030154,GO:0031090,GO:0031344,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0032501,GO:0032502,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045595,GO:0045664,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050773,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051239,GO:0051960,GO:0060284,GO:0065007,GO:0098588,GO:0098805,GO:0120035,GO:2000026	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
k59_1189253_1	1041146.ATZB01000008_gene2192	1.96e-105	325.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_1716505_1	521674.Plim_3544	3.98e-89	270.0	COG0115@1|root,COG0115@2|Bacteria,2IY3N@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_373248_1	472759.Nhal_3178	1.51e-145	424.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1WXP7@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_23780_1	1440774.Y900_004375	7.84e-152	446.0	COG0209@1|root,COG0209@2|Bacteria,2GKX9@201174|Actinobacteria,232JS@1762|Mycobacteriaceae	201174|Actinobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdE	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005971,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0016728,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0051063,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0071944,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	RNR_N,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_720209_1	439496.RBY4I_1390	1.96e-24	98.2	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2TT6A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
k59_720209_2	1163617.SCD_n01889	2.2e-09	55.5	2E7PJ@1|root,33255@2|Bacteria,1NANJ@1224|Proteobacteria,2W4P4@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_24640_1	1385521.N803_09845	8.16e-45	153.0	COG0494@1|root,COG0494@2|Bacteria,2GKG9@201174|Actinobacteria,4FGAE@85021|Intrasporangiaceae	201174|Actinobacteria	L	Nudix hydrolase	nudL	-	-	ko:K18568	ko00332,ko01130,map00332,map01130	-	R10747	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_1190009_1	880070.Cycma_4552	9.47e-223	653.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,4NF4F@976|Bacteroidetes,47U87@768503|Cytophagia	976|Bacteroidetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_775990_1	1385521.N803_03880	3.61e-25	97.8	2E37T@1|root,32Y7G@2|Bacteria,2HKU0@201174|Actinobacteria,4FHMR@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
k59_775990_2	367299.JOEE01000006_gene715	5.19e-50	169.0	COG3642@1|root,COG3642@2|Bacteria,2GIX0@201174|Actinobacteria,4FE9W@85021|Intrasporangiaceae	201174|Actinobacteria	T	Domain of unknown function (DUF4032)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4032,Kdo
k59_1659858_1	1342301.JASD01000008_gene2513	3.13e-107	333.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,3ZVE0@60136|Sulfitobacter	28211|Alphaproteobacteria	EQ	Hydantoinase/oxoprolinase N-terminal region	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k59_1841971_1	105559.Nwat_0804	5.12e-60	204.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,1WWAN@135613|Chromatiales	135613|Chromatiales	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1424994_1	765910.MARPU_11670	4.73e-83	257.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1WW77@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	-	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_661625_1	269799.Gmet_1553	4.38e-33	129.0	COG0577@1|root,COG0577@2|Bacteria,1R6DP@1224|Proteobacteria,42PWX@68525|delta/epsilon subdivisions,2WJSB@28221|Deltaproteobacteria,43TM4@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_543659_1	653733.Selin_0151	2.73e-57	197.0	COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria	2|Bacteria	P	domain, Protein	sdcS	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_484874_1	1049564.TevJSym_ba00210	1.36e-153	464.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1J51H@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019538,GO:0019752,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0070569,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_1779708_1	1266925.JHVX01000010_gene1357	1.29e-59	204.0	COG0308@1|root,COG0308@2|Bacteria,1PVVK@1224|Proteobacteria,2VIU3@28216|Betaproteobacteria,3722N@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
k59_195645_1	521460.Athe_1519	1.74e-21	101.0	COG1067@1|root,COG1067@2|Bacteria,1TQT5@1239|Firmicutes,248NE@186801|Clostridia,42FSR@68295|Thermoanaerobacterales	186801|Clostridia	O	Endopeptidase La	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C
k59_907854_1	1231241.Mc24_09209	4.57e-14	77.0	COG0086@1|root,COG0086@2|Bacteria,2GC23@200918|Thermotogae	200918|Thermotogae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_264409_1	243275.TDE_0588	3.82e-43	157.0	COG2986@1|root,COG2986@2|Bacteria,2J72J@203691|Spirochaetes	203691|Spirochaetes	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
k59_379565_1	69279.BG36_10785	2.58e-14	77.8	COG1652@1|root,COG1652@2|Bacteria,1MWMR@1224|Proteobacteria,2U7UH@28211|Alphaproteobacteria,43GQP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	protein containing LysM domain	lysM	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_1132276_1	743718.Isova_2242	3.44e-32	128.0	COG5340@1|root,COG5340@2|Bacteria,2II40@201174|Actinobacteria	201174|Actinobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4
k59_429904_1	1120956.JHZK01000003_gene251	1.21e-44	162.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TTBG@28211|Alphaproteobacteria,1JNK8@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Voltage gated chloride channel	clcA	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	Voltage_CLC
k59_1193792_1	1382356.JQMP01000003_gene2500	7.65e-08	52.0	COG0858@1|root,COG0858@2|Bacteria,2G73E@200795|Chloroflexi,27YJU@189775|Thermomicrobia	189775|Thermomicrobia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
k59_1193792_2	765914.ThisiDRAFT_1474	5.66e-100	317.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales	135613|Chromatiales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_1319032_1	441620.Mpop_1974	4.79e-59	185.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,2U5CS@28211|Alphaproteobacteria,1JUK8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
k59_1428847_1	471853.Bcav_1595	4.07e-134	391.0	COG1181@1|root,COG1181@2|Bacteria,2GITC@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_547202_1	243233.MCA3092	9.21e-59	187.0	COG1573@1|root,COG1573@2|Bacteria,1QJIF@1224|Proteobacteria,1THIQ@1236|Gammaproteobacteria,1XEAT@135618|Methylococcales	135618|Methylococcales	L	uracil-DNA	-	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_312724_1	1123065.ATWL01000008_gene2443	1.84e-91	275.0	COG1595@1|root,COG1595@2|Bacteria,2GJ02@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	sigH	GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1603323_1	666681.M301_0483	1.27e-40	151.0	COG4191@1|root,COG4585@1|root,COG4191@2|Bacteria,COG4585@2|Bacteria,1N1PW@1224|Proteobacteria,2VU49@28216|Betaproteobacteria	28216|Betaproteobacteria	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_779267_1	1049564.TevJSym_at00390	4.65e-76	244.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1J4IR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663	-	ko:K03688	-	-	-	-	ko00000	-	-	iYL1228.KPN_04331	ABC1
k59_86036_2	1121861.KB899921_gene3056	1.82e-08	59.3	COG0748@1|root,COG0748@2|Bacteria,1RFVC@1224|Proteobacteria,2TV14@28211|Alphaproteobacteria,2JS7X@204441|Rhodospirillales	204441|Rhodospirillales	P	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07226	-	-	-	-	ko00000	-	-	-	DUF2470,Putative_PNPOx,Pyrid_oxidase_2
k59_86036_3	1283284.AZUK01000001_gene1723	0.000248	41.6	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1Y5WU@135624|Aeromonadales	135624|Aeromonadales	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K22042	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
k59_966802_1	768671.ThimaDRAFT_3827	1.41e-133	387.0	COG2878@1|root,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,1RPC4@1236|Gammaproteobacteria,1WWC5@135613|Chromatiales	135613|Chromatiales	C	Fe-S cluster	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4
k59_1132289_1	1082931.KKY_221	1.48e-08	54.7	COG2141@1|root,COG2141@2|Bacteria,1MXQU@1224|Proteobacteria,2U1X1@28211|Alphaproteobacteria,3N8KI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_1132289_2	1137269.AZWL01000043_gene1269	8.23e-13	70.1	COG0778@1|root,COG1478@1|root,COG0778@2|Bacteria,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria	201174|Actinobacteria	C	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives	fbiB	GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase,Nitroreductase
k59_379592_1	1128421.JAGA01000004_gene2499	2.24e-16	83.6	COG0747@1|root,COG0747@2|Bacteria	2|Bacteria	E	dipeptide transport	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1428861_1	1283300.ATXB01000002_gene2568	1.2e-13	70.5	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,1RZ45@1236|Gammaproteobacteria,1XFSP@135618|Methylococcales	135618|Methylococcales	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
k59_1428861_2	1123368.AUIS01000019_gene1223	1.86e-61	191.0	2AHT8@1|root,3185S@2|Bacteria,1RH98@1224|Proteobacteria,1S7UG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_312738_1	485913.Krac_7825	4.76e-49	174.0	COG0173@1|root,COG0173@2|Bacteria,2G5RX@200795|Chloroflexi	200795|Chloroflexi	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_966813_1	1049564.TevJSym_ad00300	1.03e-216	609.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1J90E@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_1132300_1	395493.BegalDRAFT_0488	2.86e-141	427.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1428864_1	1144325.PMI22_00598	6.31e-23	97.4	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1S3FP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1428864_2	1144325.PMI22_00608	2.44e-37	139.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1S3FP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_312744_1	446468.Ndas_0347	6.73e-09	63.2	COG4585@1|root,COG4585@2|Bacteria,2GJKG@201174|Actinobacteria,4EIWD@85012|Streptosporangiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_1779745_1	1357275.AVEL02000109_gene4432	8.1e-24	102.0	COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,1RPGF@1236|Gammaproteobacteria,1Z6IK@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	V	MatE	dinF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
k59_1779745_2	1121935.AQXX01000075_gene5431	1.2e-06	49.3	COG4221@1|root,COG4221@2|Bacteria,1QXBX@1224|Proteobacteria,1T4IE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short
k59_1491946_1	1121405.dsmv_1990	8.09e-64	216.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,42PT5@68525|delta/epsilon subdivisions,2WIPN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NADH-quinone oxidoreductase, chain G	nuoG-2	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1369267_1	330214.NIDE2857	4.28e-125	363.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_1428869_3	768671.ThimaDRAFT_0347	2.21e-29	112.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,1RMAE@1236|Gammaproteobacteria,1WWTZ@135613|Chromatiales	135613|Chromatiales	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
k59_1545157_1	390235.PputW619_4189	4.8e-70	238.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1YVXW@136845|Pseudomonas putida group	1236|Gammaproteobacteria	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,iJN746.PP_1037,ic_1306.c3080	AIRS_C,GATase_5
k59_907912_1	935839.JAGJ01000002_gene913	3.88e-109	333.0	COG4320@1|root,COG4320@2|Bacteria,2GKEK@201174|Actinobacteria	201174|Actinobacteria	K	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
k59_907912_2	1223542.GM1_003_01660	5.46e-19	85.1	COG5361@1|root,COG5361@2|Bacteria,2GKTA@201174|Actinobacteria,4GBT8@85026|Gordoniaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1257318_1	1120970.AUBZ01000002_gene830	2.77e-67	215.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,1RM7W@1236|Gammaproteobacteria,4654B@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	potF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0019808,GO:0019810,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0051179,GO:0051234,GO:0070405,GO:0071702,GO:0071705	-	ko:K11073	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	iB21_1397.B21_00865,iECBD_1354.ECBD_2740,iECB_1328.ECB_00859,iECD_1391.ECD_00859,iEcHS_1320.EcHS_A0957,iEcolC_1368.EcolC_2742,iPC815.YPO1331	SBP_bac_8
k59_1257318_2	414684.RC1_1459	2.6e-11	63.5	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2JPVQ@204441|Rhodospirillales	204441|Rhodospirillales	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	-	ko:K11076	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	ABC_tran,TOBE_2
k59_724482_1	1267005.KB911258_gene230	6.87e-54	177.0	COG1131@1|root,COG1131@2|Bacteria,1MX56@1224|Proteobacteria,2TTQM@28211|Alphaproteobacteria,3N8KD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	ATPases associated with a variety of cellular activities	MA20_34505	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1545920_1	404589.Anae109_3714	7.87e-42	139.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,42U7E@68525|delta/epsilon subdivisions,2WPZP@28221|Deltaproteobacteria,2YVK0@29|Myxococcales	28221|Deltaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
k59_1545920_2	96561.Dole_0550	2.01e-24	101.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2MHPV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_967957_1	192222.Cj0597	3.29e-11	62.8	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,42MK7@68525|delta/epsilon subdivisions,2YMEQ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	G	fructose-bisphosphate aldolase	fbaA	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
k59_967957_2	794903.OPIT5_07630	6.28e-23	93.2	COG0526@1|root,COG0526@2|Bacteria,46SXQ@74201|Verrucomicrobia,3K8IG@414999|Opitutae	414999|Opitutae	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_7
k59_1848355_1	382464.ABSI01000020_gene121	4.61e-81	260.0	COG0500@1|root,COG0500@2|Bacteria,46YTR@74201|Verrucomicrobia,2IU3A@203494|Verrucomicrobiae	203494|Verrucomicrobiae	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Response_reg
k59_1320209_1	1280950.HJO_16982	1.29e-07	56.2	28MWZ@1|root,2ZB46@2|Bacteria,1R7K6@1224|Proteobacteria,2U4ZP@28211|Alphaproteobacteria,43ZSI@69657|Hyphomonadaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_666060_1	243233.MCA3077	8.51e-72	225.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1XDJA@135618|Methylococcales	135618|Methylococcales	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_31894_1	667632.KB890219_gene632	5.59e-25	104.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,1JZPR@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_265696_1	1307761.L21SP2_0276	2.56e-22	95.9	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,2J6WY@203691|Spirochaetes	203691|Spirochaetes	C	Iron only hydrogenase large subunit, C-terminal domain	hymC	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,NADH-G_4Fe-4S_3
k59_265696_2	338963.Pcar_1844	5.18e-45	159.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,43SYY@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Respiratory-chain NADH dehydrogenase 51 Kd subunit	-	-	1.12.1.3,1.6.5.3	ko:K00124,ko:K00335,ko:K18331	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_137828_1	1121019.AUMN01000016_gene3664	2.03e-82	261.0	COG1651@1|root,COG3004@1|root,COG1651@2|Bacteria,COG3004@2|Bacteria,2GKIK@201174|Actinobacteria,1WAVZ@1268|Micrococcaceae	201174|Actinobacteria	P	Na+/H+ antiporter 1	nhaA	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiport_1,Thioredoxin_4
k59_265699_1	595460.RRSWK_00060	1.68e-43	148.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
k59_265699_2	1232683.ADIMK_3977	1.41e-161	466.0	COG0391@1|root,COG0391@2|Bacteria,1NW3K@1224|Proteobacteria,1RQP9@1236|Gammaproteobacteria,4667U@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Uncharacterised protein family UPF0052	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
k59_841887_1	1123400.KB904755_gene2588	2.7e-100	300.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,45ZQT@72273|Thiotrichales	72273|Thiotrichales	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	-	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
k59_1370033_1	1095767.CAHD01000068_gene3063	1.18e-09	60.1	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749,ko:K17763,ko:K20978	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko03021	-	-	-	Protoglobin,STAS,STAS_2
k59_380741_1	1304885.AUEY01000001_gene3312	7.01e-67	221.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MHU5@213118|Desulfobacterales	28221|Deltaproteobacteria	S	pfam abc-1	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
k59_137836_1	1267005.KB911256_gene2073	8.05e-44	163.0	COG0664@1|root,COG1752@1|root,COG0664@2|Bacteria,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2TVQR@28211|Alphaproteobacteria,3N8X3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin,cNMP_binding
k59_1492922_1	1123257.AUFV01000020_gene2075	5.59e-38	144.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,1RN57@1236|Gammaproteobacteria,1X48I@135614|Xanthomonadales	135614|Xanthomonadales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
k59_313597_1	1156844.KB891803_gene2448	1.44e-59	202.0	COG2066@1|root,COG2066@2|Bacteria,2GKAV@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the glutaminase family	glsA	-	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Glutaminase,STAS,STAS_2,cNMP_binding
k59_548034_1	765420.OSCT_2719	3.68e-74	236.0	COG0167@1|root,COG0167@2|Bacteria,2G5T6@200795|Chloroflexi,3766V@32061|Chloroflexia	32061|Chloroflexia	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_1370040_1	1094980.Mpsy_1634	3.4e-32	127.0	COG0138@1|root,arCOG02824@2157|Archaea,2XT5P@28890|Euryarchaeota,2N92Z@224756|Methanomicrobia	224756|Methanomicrobia	F	TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase	-	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0571	AICARFT_IMPCHas,MGS
k59_265723_1	247634.GPB2148_793	1.33e-13	71.6	COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,1RQBF@1236|Gammaproteobacteria,1J62W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the peptidase S11 family	pbpG	GO:0003674,GO:0003824,GO:0004175,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K07262	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
k59_1848397_1	640132.Srot_0033	6.76e-20	89.4	2CHRY@1|root,30Z9E@2|Bacteria,2IJQT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1194682_1	1049564.TevJSym_ah00960	8.98e-53	174.0	COG0231@1|root,COG0231@2|Bacteria,1NWY9@1224|Proteobacteria,1RQ0N@1236|Gammaproteobacteria,1J673@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	COG0231 Translation elongation factor P (EF-P) translation initiation factor 5A (eIF-5A)	yeiP	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
k59_1014893_1	471852.Tcur_3730	1.44e-13	72.4	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,4EG16@85012|Streptosporangiales	201174|Actinobacteria	S	Uncharacterised protein family (UPF0182)	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_1664606_1	1323663.AROI01000006_gene3021	1.55e-30	126.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	Tfp pilus assembly protein tip-associated adhesin PilY1	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
k59_968014_1	1232410.KI421421_gene3631	1.51e-102	310.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,42MNS@68525|delta/epsilon subdivisions,2WSQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	MFS_1,TLC
k59_968014_2	211165.AJLN01000017_gene2088	3.33e-17	79.0	COG1309@1|root,COG1309@2|Bacteria,1G8UZ@1117|Cyanobacteria	1117|Cyanobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_31981_1	1121405.dsmv_2651	7.21e-61	204.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales	68525|delta/epsilon subdivisions	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_380779_1	1121939.L861_00135	2.29e-31	122.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RQJD@1236|Gammaproteobacteria,1XHCP@135619|Oceanospirillales	135619|Oceanospirillales	K	transcriptional regulator	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_87219_1	1042375.AFPL01000026_gene3760	1.84e-26	113.0	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1T1I1@1236|Gammaproteobacteria,46CYF@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_9
k59_724542_1	1384056.N787_11945	1.03e-75	239.0	COG2962@1|root,COG2962@2|Bacteria,1MX5G@1224|Proteobacteria,1RMAC@1236|Gammaproteobacteria,1X3PF@135614|Xanthomonadales	135614|Xanthomonadales	S	EamA-like transporter family	rarD	-	-	ko:K05786	-	-	-	-	ko00000,ko02000	2.A.7.7	-	-	EamA
k59_1194701_1	797209.ZOD2009_18045	2.23e-15	72.8	COG0251@1|root,arCOG01630@2157|Archaea,2XY4I@28890|Euryarchaeota,23X7B@183963|Halobacteria	183963|Halobacteria	J	translation initiation inhibitor, yjgF family	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_1604117_1	105559.Nwat_0767	6e-144	419.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1WWD4@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_841927_1	68194.JNXR01000004_gene4562	2.41e-50	182.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_87229_1	686340.Metal_0749	9.12e-89	268.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,1XE78@135618|Methylococcales	135618|Methylococcales	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
k59_968032_1	396588.Tgr7_2469	1.18e-95	293.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1WX8S@135613|Chromatiales	135613|Chromatiales	P	PFAM phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_1492966_1	1094715.CM001373_gene1641	1.92e-50	171.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,1RNHI@1236|Gammaproteobacteria,1JDZD@118969|Legionellales	118969|Legionellales	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
k59_1664623_1	471856.Jden_1108	1.23e-49	169.0	COG0016@1|root,COG0016@2|Bacteria,2GJGG@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_919085_1	879212.DespoDRAFT_02457	1.64e-54	193.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2MIYJ@213118|Desulfobacterales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1858693_1	335543.Sfum_2648	2.82e-92	281.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42NW8@68525|delta/epsilon subdivisions,2WJY1@28221|Deltaproteobacteria,2MQTN@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Dehydrogenase, E1 component	bkdA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_390778_1	744980.TRICHSKD4_4097	6.8e-135	400.0	COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,2TRVM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	phosphatase	-	-	-	ko:K07093	-	-	-	-	ko00000	-	-	-	DUF839
k59_612491_1	223926.28808615	3.15e-55	191.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RSP9@1236|Gammaproteobacteria,1XXZ7@135623|Vibrionales	135623|Vibrionales	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_273802_1	485915.Dret_0075	9.85e-59	194.0	COG0240@1|root,COG0240@2|Bacteria,1MXI9@1224|Proteobacteria,42TEU@68525|delta/epsilon subdivisions,2WPTF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM NAD NADP octopine nopaline dehydrogenase	-	-	1.5.1.28	ko:K04940	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored,Octopine_DH
k59_730198_1	1035308.AQYY01000001_gene2593	1.8e-116	343.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,248H9@186801|Clostridia,263YH@186807|Peptococcaceae	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase	pdxB	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_495193_1	1163617.SCD_n01907	2.4e-55	185.0	COG2863@1|root,COG2863@2|Bacteria,1RBXV@1224|Proteobacteria,2VQHD@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_978212_1	1297570.MESS4_290017	3.5e-23	97.8	2E06S@1|root,32UJS@2|Bacteria,1N30K@1224|Proteobacteria,2UDJX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_978212_2	1144307.PMI04_02525	6.01e-08	53.9	2DNBN@1|root,32WN2@2|Bacteria,1N5BF@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
k59_1090848_1	493475.GARC_0034	1.83e-78	249.0	COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,1SJVX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	FAD dependent oxidoreductase	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
k59_1435523_1	446466.Cfla_2585	6.21e-179	511.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2GITZ@201174|Actinobacteria,4F0EC@85016|Cellulomonadaceae	201174|Actinobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006183,GO:0006195,GO:0006204,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009125,GO:0009126,GO:0009127,GO:0009128,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009154,GO:0009156,GO:0009158,GO:0009161,GO:0009163,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009169,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009261,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046037,GO:0046039,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
k59_1435523_2	471853.Bcav_3056	3.79e-64	214.0	COG0789@1|root,COG0789@2|Bacteria,2I8T8@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding_2,MerR_1
k59_1435523_3	1454010.JEOE01000012_gene1563	8.58e-10	55.1	2CC1Y@1|root,32S23@2|Bacteria,2IQS5@201174|Actinobacteria,4F1GH@85016|Cellulomonadaceae	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB3	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
k59_1200459_1	743299.Acife_3211	2.92e-55	184.0	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,1RN4G@1236|Gammaproteobacteria,2NC9T@225057|Acidithiobacillales	225057|Acidithiobacillales	C	FAD binding domain	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_671687_1	177437.HRM2_02020	5.88e-33	128.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42PUP@68525|delta/epsilon subdivisions,2WMAH@28221|Deltaproteobacteria,2MN7Y@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_436456_1	395492.Rleg2_3777	3.07e-43	151.0	COG3440@1|root,COG3440@2|Bacteria,1NE0N@1224|Proteobacteria,2TV2B@28211|Alphaproteobacteria,4BDVT@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	HNH endonuclease	-	-	-	ko:K07454	-	-	-	-	ko00000	-	-	-	HNH_2
k59_1551318_1	388399.SSE37_03280	3.1e-59	191.0	COG1126@1|root,COG1126@2|Bacteria,1MWKQ@1224|Proteobacteria,2TSCU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC-type polar amino acid transport system ATPase component	-	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran
k59_1551318_2	314231.FP2506_17974	2.95e-42	147.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,2TU33@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	COG2998 ABC-type tungstate transport system, permease component	tupA	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
k59_273829_1	272943.RSP_1590	8.72e-11	65.1	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,1FAQQ@1060|Rhodobacter	28211|Alphaproteobacteria	T	Two component, sigma54 specific transcriptional regulator, fis family	luxO	-	-	ko:K10912	ko02020,ko02024,ko05111,map02020,map02024,map05111	M00513	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_273829_2	371731.Rsw2DRAFT_2586	2.17e-29	113.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2TR90@28211|Alphaproteobacteria,1FBDW@1060|Rhodobacter	28211|Alphaproteobacteria	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_1138285_1	243233.MCA2447	2.43e-127	389.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1XDRZ@135618|Methylococcales	135618|Methylococcales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_1858754_1	1297865.APJD01000069_gene5777	1.52e-15	79.7	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3JR1M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_319502_1	1254432.SCE1572_24420	3.06e-52	187.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,42NFP@68525|delta/epsilon subdivisions,2X7WN@28221|Deltaproteobacteria,2YXQ6@29|Myxococcales	28221|Deltaproteobacteria	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_1330490_1	573413.Spirs_2458	4.46e-89	273.0	COG1156@1|root,COG1156@2|Bacteria,2J574@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_612535_1	570967.JMLV01000004_gene499	3e-66	214.0	COG3660@1|root,COG3660@2|Bacteria,1R70U@1224|Proteobacteria,2TQWV@28211|Alphaproteobacteria,2JTHZ@204441|Rhodospirillales	204441|Rhodospirillales	M	Mitochondrial fission ELM1	-	-	-	ko:K07276	-	-	-	-	ko00000	-	-	-	Mito_fiss_Elm1
k59_390858_1	697282.Mettu_2365	3.16e-09	60.8	COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,1RSJC@1236|Gammaproteobacteria,1XEMK@135618|Methylococcales	135618|Methylococcales	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_390858_2	745411.B3C1_06473	1.04e-09	58.2	2DP15@1|root,3303T@2|Bacteria,1N7NN@1224|Proteobacteria,1S90P@1236|Gammaproteobacteria,1J6SN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4426)	PP5099	-	-	-	-	-	-	-	-	-	-	-	DUF4426
k59_1019746_1	1463854.JOHT01000016_gene6977	5.24e-83	291.0	COG1502@1|root,COG1502@2|Bacteria,2IEFK@201174|Actinobacteria	201174|Actinobacteria	I	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_1551348_1	521003.COLINT_02563	2.6e-05	51.2	COG2385@1|root,COG2385@2|Bacteria,2I2J0@201174|Actinobacteria	201174|Actinobacteria	D	Pfam Stage II sporulation	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,ChW,VCBS
k59_919182_1	288000.BBta_2154	2.46e-15	82.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2V4ME@28211|Alphaproteobacteria,3JX3G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_7,Response_reg
k59_847702_1	1284352.AOIG01000009_gene1773	6.65e-17	81.6	COG0491@1|root,COG0491@2|Bacteria,1V5YS@1239|Firmicutes,4HVTY@91061|Bacilli,26V4N@186822|Paenibacillaceae	91061|Bacilli	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_553866_1	765914.ThisiDRAFT_1157	5.37e-103	330.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1019753_1	367299.JOEE01000002_gene2377	4.08e-127	367.0	COG0388@1|root,COG0388@2|Bacteria,2GMQA@201174|Actinobacteria,4FE90@85021|Intrasporangiaceae	201174|Actinobacteria	S	apolipoprotein N-acyltransferase	mtnU	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
k59_919197_1	225849.swp_4746	7.27e-10	63.9	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,2QB92@267890|Shewanellaceae	1236|Gammaproteobacteria	M	surface antigen variable number repeat protein	plpD	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k59_273885_1	713586.KB900536_gene1938	6.72e-70	238.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,NB-ARC,cNMP_binding
k59_1551364_1	367299.JOEE01000008_gene567	2.69e-65	223.0	COG0419@1|root,COG0419@2|Bacteria,2GKYR@201174|Actinobacteria,4FFJY@85021|Intrasporangiaceae	201174|Actinobacteria	L	COG0419 ATPase involved in DNA repair	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SbcCD_C
k59_847719_1	1461580.CCAS010000022_gene2388	2.95e-23	103.0	COG0860@1|root,COG1876@1|root,COG0860@2|Bacteria,COG1876@2|Bacteria,1UZ9V@1239|Firmicutes,4I2DK@91061|Bacilli,1ZEBE@1386|Bacillus	91061|Bacilli	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,ChW
k59_847719_2	1172188.KB911824_gene3388	3.09e-13	68.9	COG2898@1|root,COG2898@2|Bacteria,2GM2C@201174|Actinobacteria,4FEF8@85021|Intrasporangiaceae	201174|Actinobacteria	S	Uncharacterised conserved protein (DUF2156)	lysX	-	-	-	-	-	-	-	-	-	-	-	DUF2156
k59_1090929_2	1232410.KI421426_gene1511	8.69e-78	240.0	COG1136@1|root,COG1136@2|Bacteria,1RE7J@1224|Proteobacteria,43AW8@68525|delta/epsilon subdivisions,2X6AH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_978334_1	589924.Ferp_0003	0.000132	45.1	COG1060@1|root,arCOG00656@2157|Archaea,2XU6S@28890|Euryarchaeota,245QQ@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO)	cofH	-	2.5.1.77	ko:K11781	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
k59_978334_2	909663.KI867149_gene3195	3.7e-46	157.0	COG2107@1|root,COG2107@2|Bacteria,1NYEA@1224|Proteobacteria,42MXB@68525|delta/epsilon subdivisions,2WIMS@28221|Deltaproteobacteria,2MRUI@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Menaquinone biosynthesis	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
k59_97463_1	261292.Nit79A3_0138	2.88e-59	195.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_32
k59_1858830_2	95619.PM1_0228815	3.24e-88	270.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_3165,iECOK1_1307.ECOK1_3701,iECS88_1305.ECS88_3669,iECUMN_1333.ECUMN_3755,iSBO_1134.SBO_3275,iUMN146_1321.UM146_16315,iUTI89_1310.UTI89_C3726	Shikimate_DH,Shikimate_dh_N
k59_1858830_3	1122604.JONR01000068_gene4230	2.4e-76	233.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria,1X514@135614|Xanthomonadales	135614|Xanthomonadales	S	carbonic	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
k59_1858830_4	62928.azo0659	3.08e-05	45.1	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2VHFA@28216|Betaproteobacteria,2KYJ7@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1375459_1	1122604.JONR01000028_gene3493	3.93e-40	139.0	COG0500@1|root,COG2226@2|Bacteria,1RANW@1224|Proteobacteria,1S1F0@1236|Gammaproteobacteria,1X5TS@135614|Xanthomonadales	135614|Xanthomonadales	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
k59_847724_1	760117.JN27_13480	3.5e-75	243.0	COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,2VHGV@28216|Betaproteobacteria,472BD@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB	hscA	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141	-	ko:K04044	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
k59_1551376_1	1410624.JNKK01000006_gene1923	1.1e-25	97.1	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,24QJE@186801|Clostridia,27PMB@186928|unclassified Lachnospiraceae	186801|Clostridia	K	'Cold-shock' DNA-binding domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_1670494_1	1049564.TevJSym_ac00480	2.04e-67	221.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1J4I6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	JKL	DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlE	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_1019762_1	471853.Bcav_1900	4.17e-209	600.0	COG0322@1|root,COG2176@1|root,COG0322@2|Bacteria,COG2176@2|Bacteria,2GMC0@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase III, epsilon subunit	dnaQ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,UVR
k59_1019762_2	1306174.JODP01000009_gene6542	1.69e-10	59.7	2EGHN@1|root,33A9R@2|Bacteria,2GSZ1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1019762_3	471856.Jden_1442	7.56e-139	413.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria	201174|Actinobacteria	I	AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_1375475_1	1284686.HMPREF1630_06910	1.41e-42	157.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,22G6N@1570339|Peptoniphilaceae	186801|Clostridia	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
k59_1551388_1	1255043.TVNIR_3824	6.95e-129	380.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1WWBG@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_1858859_1	1112214.AHIS01000027_gene1020	5.85e-76	269.0	COG0726@1|root,COG1215@1|root,COG3858@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,1MXG7@1224|Proteobacteria,2TVZ5@28211|Alphaproteobacteria,2K1ER@204457|Sphingomonadales	204457|Sphingomonadales	GM	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_18,Glyco_tranf_2_3,Polysacc_deac_1
k59_1265059_1	998674.ATTE01000001_gene1872	4.47e-185	545.0	COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria,46062@72273|Thiotrichales	72273|Thiotrichales	HJM	Carbamoyl-phosphate synthase L chain, ATP binding domain	cphA	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	CPSase_L_D2,Mur_ligase_C,Mur_ligase_M,RimK
k59_1858867_1	439235.Dalk_3994	1.11e-159	469.0	COG5421@1|root,COG5421@2|Bacteria,1R6MI@1224|Proteobacteria,42U8I@68525|delta/epsilon subdivisions,2WQCY@28221|Deltaproteobacteria,2MNWM@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1499508_1	1279017.AQYJ01000025_gene645	2.97e-12	65.5	COG1802@1|root,COG1802@2|Bacteria,1NDRT@1224|Proteobacteria,1RYXQ@1236|Gammaproteobacteria,466TS@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	COG1802 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_1499508_2	765912.Thimo_2679	1.21e-76	236.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,1RMR5@1236|Gammaproteobacteria,1WWC7@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	prpB	-	4.1.3.30	ko:K03417	ko00640,map00640	-	R00409	RC00286,RC00287	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
k59_1499512_1	709032.Sulku_2130	2.21e-59	197.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42T55@68525|delta/epsilon subdivisions,2YQJT@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	Glycosyl transferase 4-like	-	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1
k59_919300_1	419947.MRA_1160	1.27e-73	230.0	COG3293@1|root,COG3293@2|Bacteria,2GN92@201174|Actinobacteria,239P5@1762|Mycobacteriaceae	201174|Actinobacteria	L	Transposase DDE domain	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2
k59_847759_1	113395.AXAI01000009_gene2628	1.07e-17	80.5	COG4032@1|root,COG4032@2|Bacteria,1R53S@1224|Proteobacteria,2TT20@28211|Alphaproteobacteria,3JTZJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	MA20_15000	-	4.1.1.79	ko:K06034	ko00680,ko01120,map00680,map01120	M00358	R05774	RC00506	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_N
k59_847759_2	331869.BAL199_03359	1.64e-23	96.7	COG0028@1|root,COG0028@2|Bacteria,1R6QP@1224|Proteobacteria,2TUEF@28211|Alphaproteobacteria,4BSZC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EH	COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase	MA20_15005	-	4.1.1.79	ko:K13039	ko00680,ko01120,map00680,map01120	M00358	R05774	RC00506	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_495317_1	1300350.DSW25_11810	8.53e-74	236.0	COG4177@1|root,COG4177@2|Bacteria,1NY9G@1224|Proteobacteria,2TTSN@28211|Alphaproteobacteria,3ZXP7@60136|Sulfitobacter	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1671192_2	595460.RRSWK_03964	8.24e-40	136.0	2DMKI@1|root,32S70@2|Bacteria,2J03R@203682|Planctomycetes	203682|Planctomycetes	S	SpoIIAA-like	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
k59_98668_1	1127131.WEISSC39_01590	1.39e-11	68.9	COG2367@1|root,COG2367@2|Bacteria,1VBZ3@1239|Firmicutes,4HN99@91061|Bacilli,4AZ0W@81850|Leuconostocaceae	91061|Bacilli	V	Beta-lactamase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase2
k59_1860094_1	1159870.KB907784_gene742	5.95e-121	379.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,3T78H@506|Alcaligenaceae	28216|Betaproteobacteria	C	Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits	-	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
k59_202800_1	765913.ThidrDRAFT_2847	1.8e-82	259.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,1RR7X@1236|Gammaproteobacteria,1WW9A@135613|Chromatiales	135613|Chromatiales	G	PFAM carbohydrate kinase	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
k59_1265899_1	28229.ND2E_1882	1.53e-57	194.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,1RNQI@1236|Gammaproteobacteria,2Q7EN@267889|Colwelliaceae	1236|Gammaproteobacteria	M	Mannose-6-phosphate isomerase	cpsB	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_1201202_1	765911.Thivi_3998	4.47e-112	340.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1WW1V@135613|Chromatiales	135613|Chromatiales	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
k59_672504_1	1121405.dsmv_3066	1.35e-36	141.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,2MHU0@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_554588_1	1121015.N789_11575	1.5e-30	118.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,1X3T4@135614|Xanthomonadales	135614|Xanthomonadales	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	dsbC	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
k59_554588_2	1265490.JHVY01000022_gene2391	8.79e-21	86.7	COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the UPF0234 family	yajQ	GO:0000049,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
k59_1020325_1	1049564.TevJSym_as00340	1.66e-44	156.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,1RMDQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_1382956_2	1232437.KL662047_gene5175	1.92e-12	64.7	COG1917@1|root,COG1917@2|Bacteria,1N0G1@1224|Proteobacteria,42U3P@68525|delta/epsilon subdivisions,2WPN5@28221|Deltaproteobacteria,2MNEN@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_1616984_1	1082933.MEA186_30901	2.73e-23	109.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_931322_1	1123518.ARWI01000001_gene1023	1.43e-46	154.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,1S1Z1@1236|Gammaproteobacteria,460IG@72273|Thiotrichales	72273|Thiotrichales	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_931322_2	1547445.LO80_07525	2.89e-21	87.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,1S5V2@1236|Gammaproteobacteria,460WC@72273|Thiotrichales	72273|Thiotrichales	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
k59_1870957_1	933262.AXAM01000001_gene336	9.57e-87	271.0	COG1960@1|root,COG1960@2|Bacteria,1NU73@1224|Proteobacteria,42Z96@68525|delta/epsilon subdivisions,2WTTK@28221|Deltaproteobacteria,2MN2J@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_790862_1	768671.ThimaDRAFT_2565	6.41e-78	251.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1WX4I@135613|Chromatiales	135613|Chromatiales	D	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1507886_1	1417296.U879_13505	0.0	905.0	COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,2U9U2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_1507886_2	1122614.JHZF01000020_gene202	2.83e-78	233.0	COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,2U7TH@28211|Alphaproteobacteria,2PER1@252301|Oceanicola	28211|Alphaproteobacteria	L	IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k59_1507886_3	1417296.U879_13495	1.19e-49	162.0	COG2963@1|root,COG2963@2|Bacteria,1N60A@1224|Proteobacteria,2UDY7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_402949_2	876269.ARWA01000001_gene1073	3.96e-11	65.9	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2TV9T@28211|Alphaproteobacteria,3NAFI@45404|Beijerinckiaceae	28211|Alphaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_1144575_1	765911.Thivi_2495	1.29e-65	209.0	COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,1RZQ2@1236|Gammaproteobacteria,1WXSM@135613|Chromatiales	135613|Chromatiales	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_990559_2	1254432.SCE1572_10500	1.41e-68	218.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,42MCP@68525|delta/epsilon subdivisions,2WJDS@28221|Deltaproteobacteria,2YWXN@29|Myxococcales	28221|Deltaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	iAF987.Gmet_0409	Glycos_transf_4,MraY_sig1
k59_284149_1	1304885.AUEY01000006_gene724	4.64e-58	185.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2WJDF@28221|Deltaproteobacteria,2MIR4@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_284149_2	439235.Dalk_3162	1.85e-38	133.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,42NAA@68525|delta/epsilon subdivisions,2WNMN@28221|Deltaproteobacteria,2MJ2A@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_1099077_1	1249627.D779_1421	3.48e-07	53.1	COG0845@1|root,COG0845@2|Bacteria,1MWZ9@1224|Proteobacteria,1RM91@1236|Gammaproteobacteria,1WX23@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
k59_1099077_2	1353537.TP2_13440	3.2e-57	181.0	COG3255@1|root,COG3255@2|Bacteria,1RI49@1224|Proteobacteria,2UF1P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1507918_2	653386.HMPREF0975_00467	2.38e-05	50.1	COG0215@1|root,COG0215@2|Bacteria,2GJF2@201174|Actinobacteria,4D4GB@85005|Actinomycetales	201174|Actinobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
k59_402987_1	1304865.JAGF01000001_gene3303	9.02e-78	243.0	COG0673@1|root,COG0673@2|Bacteria,2IE7D@201174|Actinobacteria	201174|Actinobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_990584_1	1535422.ND16A_0236	1.76e-27	117.0	COG2982@1|root,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,1RNPC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748,OmpA
k59_443923_1	1121403.AUCV01000004_gene2045	5.04e-51	174.0	29J9T@1|root,3067A@2|Bacteria,1RE8D@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF2860)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2860
k59_1273558_1	697282.Mettu_4268	3.22e-91	298.0	28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria,1S1M3@1236|Gammaproteobacteria,1XDZM@135618|Methylococcales	135618|Methylococcales	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
k59_561161_1	926564.KI911615_gene4424	6.38e-06	52.0	COG5628@1|root,COG5628@2|Bacteria,2IIBP@201174|Actinobacteria	201174|Actinobacteria	S	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1099855_2	446469.Sked_18010	7.42e-54	178.0	COG0284@1|root,COG0284@2|Bacteria,2GKWK@201174|Actinobacteria	201174|Actinobacteria	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_932513_1	1125700.HMPREF9195_00503	1.38e-97	298.0	COG0281@1|root,COG0281@2|Bacteria,2J5DN@203691|Spirochaetes	203691|Spirochaetes	C	Malic enzyme, NAD binding domain	mdh	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
k59_444717_1	244581.IM40_08665	2.58e-34	131.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2TS2H@28211|Alphaproteobacteria,47FC6@766|Rickettsiales	766|Rickettsiales	M	COG1560 Lauroyl myristoyl acyltransferase	htrB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_991731_1	227086.JGI_V11_57641	9.09e-31	120.0	COG1816@1|root,KOG1097@2759|Eukaryota	2759|Eukaryota	F	hypoxanthine salvage	-	GO:0000034,GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046083,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046113,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
k59_991731_2	556269.ACDQ01000001_gene1247	6.8e-06	47.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2VH5M@28216|Betaproteobacteria,472B6@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_152009_1	911045.PSE_1104	5.35e-42	150.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TU0K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_152009_2	697282.Mettu_4009	4.34e-28	112.0	COG0398@1|root,COG0398@2|Bacteria,1MVF3@1224|Proteobacteria,1SA94@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_791558_1	439235.Dalk_0594	2.03e-07	57.8	COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,42N3Y@68525|delta/epsilon subdivisions,2WJFS@28221|Deltaproteobacteria,2MJEA@213118|Desulfobacterales	28221|Deltaproteobacteria	M	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_152016_1	1267005.KB911255_gene2962	2.81e-101	303.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,2TQVX@28211|Alphaproteobacteria,3N678@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	endonuclease III	mutY	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
k59_503364_1	264198.Reut_A1741	4.27e-153	453.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2VH5H@28216|Betaproteobacteria,1K3VG@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_1099890_1	933262.AXAM01000001_gene361	9.8e-96	293.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,42M9X@68525|delta/epsilon subdivisions,2WJ7E@28221|Deltaproteobacteria,2MIA5@213118|Desulfobacterales	28221|Deltaproteobacteria	L	AAA ATPase	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_1343988_1	1205680.CAKO01000004_gene3563	9.07e-30	117.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2TQVI@28211|Alphaproteobacteria,2JQXC@204441|Rhodospirillales	204441|Rhodospirillales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_738870_1	446466.Cfla_1796	7.02e-70	221.0	COG2255@1|root,COG2255@2|Bacteria,2GJZF@201174|Actinobacteria,4F0UA@85016|Cellulomonadaceae	201174|Actinobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_738870_2	935839.JAGJ01000003_gene1458	7.64e-30	113.0	COG1862@1|root,COG1862@2|Bacteria,2I0MQ@201174|Actinobacteria,4F4UK@85017|Promicromonosporaceae	201174|Actinobacteria	U	Preprotein translocase subunit	-	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
k59_561955_1	109760.SPPG_08431T0	4.39e-07	56.6	COG2966@1|root,2QPMM@2759|Eukaryota,39PMF@33154|Opisthokonta,3NWBX@4751|Fungi	4751|Fungi	S	Duf1212 domain membrane protein	PRM10	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0012505,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034220,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0098656,GO:1903825,GO:1905039	-	-	-	-	-	-	-	-	-	-	ThrE,ThrE_2
k59_932560_1	1121946.AUAX01000004_gene523	1.14e-08	58.2	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4D9HX@85008|Micromonosporales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1145370_1	1131269.AQVV01000009_gene1094	3.52e-31	125.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_1383926_1	1121935.AQXX01000132_gene2644	3.84e-84	263.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1XH53@135619|Oceanospirillales	135619|Oceanospirillales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	coxA	-	1.10.3.10,1.9.3.1	ko:K02274,ko:K02298	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081,R11335	RC00016,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX1
k59_1383926_3	1469245.JFBG01000016_gene965	9.2e-59	189.0	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,1S5XA@1236|Gammaproteobacteria,1X0T0@135613|Chromatiales	135613|Chromatiales	O	PFAM Cytochrome c oxidase assembly protein CtaG Cox11	-	-	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
k59_1099911_1	1121356.AQUW01000002_gene1693	2.51e-20	89.4	COG2326@1|root,COG2326@2|Bacteria,2GKRN@201174|Actinobacteria,22JKC@1653|Corynebacteriaceae	201174|Actinobacteria	S	polyphosphate kinase	ppk2	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005525,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006183,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030808,GO:0031323,GO:0031326,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046777,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051704,GO:0055086,GO:0062012,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0080090,GO:0090407,GO:0097159,GO:0097367,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
k59_1099911_2	710687.KI912270_gene3680	7.72e-34	125.0	COG5031@1|root,COG5031@2|Bacteria,2IF2J@201174|Actinobacteria,236U3@1762|Mycobacteriaceae	201174|Actinobacteria	H	ubiquinone biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_285120_1	1280952.HJA_07102	1.25e-75	237.0	28JJ3@1|root,2Z9C7@2|Bacteria,1R3Y0@1224|Proteobacteria,2U0DT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_22330	-	-	-	-	-	-	-	-	-	-	-	-
k59_680284_1	768671.ThimaDRAFT_1369	1.91e-107	335.0	COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,1QTS5@1224|Proteobacteria,1RMJS@1236|Gammaproteobacteria,1WW9Q@135613|Chromatiales	135613|Chromatiales	C	belongs to the CobB CobQ family	-	-	2.3.1.8	ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,DRTGG,PTA_PTB
k59_1617942_1	243233.MCA2039	1.62e-105	340.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1XEDS@135618|Methylococcales	135618|Methylococcales	E	Glutamate synthase	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_327714_1	1304865.JAGF01000001_gene2391	2.98e-24	99.0	COG0736@1|root,COG0736@2|Bacteria	2|Bacteria	I	holo-[acyl-carrier-protein] synthase activity	acpS	-	2.7.8.7	ko:K00997,ko:K06925	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000,ko03016	-	-	-	ACPS
k59_1443746_1	1267005.KB911259_gene3836	6.09e-57	182.0	COG0454@1|root,COG0454@2|Bacteria,1QUD7@1224|Proteobacteria,2U5MN@28211|Alphaproteobacteria,3N7GM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	ko:K03830	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_10
k59_1508773_1	977880.RALTA_A2486	3.34e-110	335.0	COG0436@1|root,COG0436@2|Bacteria,1QE0D@1224|Proteobacteria,2VIUB@28216|Betaproteobacteria,1K0XZ@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate	asdA	-	4.1.1.12	ko:K09758	ko00250,ko00270,ko01100,ko01230,map00250,map00270,map01100,map01230	-	R00397,R00863	RC00282,RC00399,RC00400	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
k59_52384_2	572477.Alvin_3112	1.42e-90	270.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1WWXG@135613|Chromatiales	135613|Chromatiales	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
k59_1792642_1	1216007.AOPM01000008_gene1386	6.93e-39	135.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,1S24R@1236|Gammaproteobacteria,2Q2KN@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Belongs to the UPF0312 family	yceI	-	-	-	-	-	-	-	-	-	-	-	YceI
k59_1792642_2	712898.Pvag_0860	4.69e-50	166.0	COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,1S3RF@1236|Gammaproteobacteria,3W00P@53335|Pantoea	1236|Gammaproteobacteria	C	Cytochrome B561	yceJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
k59_52392_1	1380394.JADL01000012_gene1023	2.33e-82	255.0	COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,2TRCC@28211|Alphaproteobacteria,2JQJ4@204441|Rhodospirillales	204441|Rhodospirillales	E	Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal	-	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
k59_1872232_1	765912.Thimo_0727	1.04e-28	119.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1WXD9@135613|Chromatiales	135613|Chromatiales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_1145399_1	247633.GP2143_16276	5.79e-71	223.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,1J5A0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_110698_1	177437.HRM2_14460	1.89e-38	139.0	28K4S@1|root,2Z9TM@2|Bacteria,1N4AQ@1224|Proteobacteria,42PSN@68525|delta/epsilon subdivisions,2WNF4@28221|Deltaproteobacteria,2MM7R@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1443765_2	247156.NFA_41220	5.93e-52	178.0	COG0583@1|root,COG0583@2|Bacteria,2GMPE@201174|Actinobacteria,4FURE@85025|Nocardiaceae	201174|Actinobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LysR_substrate
k59_1443765_3	1121405.dsmv_2676	8.01e-19	86.7	COG4924@1|root,COG4924@2|Bacteria,1P11B@1224|Proteobacteria,42QM0@68525|delta/epsilon subdivisions,2WJ1X@28221|Deltaproteobacteria,2MMKB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Uncharacterized protein conserved in bacteria C-term(DUF2220)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2220,DUF3322
k59_1274451_1	768671.ThimaDRAFT_0847	1.56e-93	295.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1SA31@1236|Gammaproteobacteria	1224|Proteobacteria	T	SMART ATP-binding region, ATPase-like	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3
k59_1208553_1	880072.Desac_0500	2.86e-31	121.0	COG1804@1|root,COG1804@2|Bacteria,1NWFC@1224|Proteobacteria,4300F@68525|delta/epsilon subdivisions,2X2A6@28221|Deltaproteobacteria,2MRS4@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_1208553_2	1121468.AUBR01000012_gene2600	2.59e-37	137.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia	186801|Clostridia	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_1145421_1	1121378.KB899719_gene408	4e-62	196.0	COG0605@1|root,COG0605@2|Bacteria,1WIJ1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	radicals which are normally produced within the cells and which are toxic to biological systems	sodA	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
k59_1617987_1	395964.KE386496_gene179	1.73e-12	71.6	COG0604@1|root,COG0604@2|Bacteria,1R6TV@1224|Proteobacteria,2U1JE@28211|Alphaproteobacteria,3NAVV@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
k59_327756_1	1068978.AMETH_1716	3.82e-35	135.0	COG0582@1|root,COG0582@2|Bacteria,2GISN@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	intA	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
k59_1508819_1	478801.Ksed_06210	3.13e-65	201.0	COG0662@1|root,COG0662@2|Bacteria,2IMPE@201174|Actinobacteria	201174|Actinobacteria	G	COG0662 Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_1508819_2	1193181.BN10_130055	8.82e-52	170.0	COG0580@1|root,COG0580@2|Bacteria,2GKK3@201174|Actinobacteria,4FFX1@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the MIP aquaporin (TC 1.A.8) family	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
k59_620671_1	1232410.KI421415_gene3030	2.95e-24	105.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42N8Y@68525|delta/epsilon subdivisions,2WIR7@28221|Deltaproteobacteria,43SUM@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	pyridine nucleotide-disulphide oxidoreductase dimerisation region	lpdA-2	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim,SNARE_assoc
k59_1508821_1	522306.CAP2UW1_1231	1.05e-28	112.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2VI78@28216|Betaproteobacteria,1KPN2@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_1736099_1	1123065.ATWL01000005_gene1351	1.35e-108	327.0	COG0114@1|root,COG0114@2|Bacteria,2GKWY@201174|Actinobacteria	201174|Actinobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_991873_1	1284686.HMPREF1630_04915	3.01e-12	65.5	COG4708@1|root,COG4708@2|Bacteria,1V9YK@1239|Firmicutes,24N9H@186801|Clostridia,22H5S@1570339|Peptoniphilaceae	186801|Clostridia	S	QueT transporter	-	-	-	-	-	-	-	-	-	-	-	-	QueT
k59_991873_2	1283299.AUKG01000001_gene3180	5.14e-21	92.0	COG0796@1|root,COG0796@2|Bacteria,2GN4I@201174|Actinobacteria,4CQ0N@84995|Rubrobacteria	84995|Rubrobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
k59_1736103_1	870187.Thini_2000	3.13e-67	209.0	COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,1S302@1236|Gammaproteobacteria,462CF@72273|Thiotrichales	72273|Thiotrichales	C	Protein of unknown function (DUF3501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
k59_791638_1	717785.HYPMC_4587	6.04e-88	264.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2TUSG@28211|Alphaproteobacteria,3N6WW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
k59_562036_1	1040982.AXAL01000012_gene882	3.27e-34	135.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2TRJE@28211|Alphaproteobacteria,43IBC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Circularly permuted ATP-grasp type 2	MA20_16190	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
k59_932678_1	710696.Intca_0075	1.29e-118	347.0	COG1175@1|root,COG1175@2|Bacteria,2GJWM@201174|Actinobacteria	201174|Actinobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17316	ko02010,map02010	M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.24,3.A.1.1.30	-	-	BPD_transp_1
k59_1026608_1	1004785.AMBLS11_10535	3.5e-60	211.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,463YW@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_863558_1	1304865.JAGF01000001_gene2441	4e-106	311.0	COG1941@1|root,COG1941@2|Bacteria,2GSPN@201174|Actinobacteria	201174|Actinobacteria	C	NADH ubiquinone oxidoreductase, 20	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
k59_863564_1	1116472.MGMO_3c00030	2.73e-18	87.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XDYH@135618|Methylococcales	135618|Methylococcales	T	Diguanylate cyclase phosphodiesterase with PAS PAC	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9,Response_reg
k59_1567175_2	765912.Thimo_3676	6.63e-62	198.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1T02D@1236|Gammaproteobacteria,1WW5T@135613|Chromatiales	135613|Chromatiales	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_1686588_2	63737.Npun_R3338	2.82e-25	108.0	COG4249@1|root,COG4249@2|Bacteria,1G42B@1117|Cyanobacteria,1HPW7@1161|Nostocales	1117|Cyanobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
k59_1686593_1	768671.ThimaDRAFT_0569	1.44e-54	187.0	COG1169@1|root,COG1169@2|Bacteria,1MVB7@1224|Proteobacteria,1RNSR@1236|Gammaproteobacteria,1WX25@135613|Chromatiales	135613|Chromatiales	HQ	isochorismate	-	-	5.4.4.2	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
k59_336007_1	497964.CfE428DRAFT_5440	5.99e-113	359.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,46TG1@74201|Verrucomicrobia	74201|Verrucomicrobia	E	B12 binding domain	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_1799419_1	1236541.BALL01000011_gene1805	2.96e-09	55.8	COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,1S3PQ@1236|Gammaproteobacteria,2Q8XC@267890|Shewanellaceae	1236|Gammaproteobacteria	L	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010468,GO:0010604,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0033554,GO:0034353,GO:0034641,GO:0034655,GO:0043167,GO:0043169,GO:0043170,GO:0043487,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0045935,GO:0046483,GO:0046700,GO:0046872,GO:0048518,GO:0048519,GO:0048522,GO:0050779,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:1901360,GO:1901361,GO:1901575	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
k59_1799419_2	631362.Thi970DRAFT_02737	3.72e-50	165.0	COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria,1WXJF@135613|Chromatiales	135613|Chromatiales	E	HAD-superfamily subfamily IB hydrolase, TIGR01490	-	-	-	-	-	-	-	-	-	-	-	-	HAD
k59_1451624_1	1123228.AUIH01000008_gene2428	6.45e-55	190.0	COG2807@1|root,COG2807@2|Bacteria,1NXQ2@1224|Proteobacteria,1RXXM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1567187_2	519989.ECTPHS_10636	4.69e-49	162.0	COG0791@1|root,COG0791@2|Bacteria,1N0EE@1224|Proteobacteria,1RP3P@1236|Gammaproteobacteria,1WYJV@135613|Chromatiales	135613|Chromatiales	M	pfam nlp p60	-	-	-	ko:K13695	-	-	-	-	ko00000,ko01002	-	-	-	NLPC_P60
k59_1517492_2	471853.Bcav_2314	2.07e-55	179.0	COG1585@1|root,COG1585@2|Bacteria,2IHZU@201174|Actinobacteria	201174|Actinobacteria	OU	Membrane protein implicated in regulation of membrane protease activity	nfeD	-	-	-	-	-	-	-	-	-	-	-	NfeD
k59_1517492_3	1095767.CAHD01000215_gene542	2.09e-104	308.0	COG1119@1|root,COG1119@2|Bacteria,2GIXX@201174|Actinobacteria,4F0VB@85016|Cellulomonadaceae	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	ylmA	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_1391423_1	1410650.JHWL01000013_gene455	3.86e-17	82.0	COG0523@1|root,COG0523@2|Bacteria,1TPCG@1239|Firmicutes,248XD@186801|Clostridia,4BW4I@830|Butyrivibrio	186801|Clostridia	S	CobW/HypB/UreG, nucleotide-binding domain	cobW	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
k59_746711_2	103690.17135031	1.71e-33	127.0	COG1611@1|root,COG1611@2|Bacteria,1G0JD@1117|Cyanobacteria,1HS06@1161|Nostocales	1117|Cyanobacteria	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_687990_1	1163409.UUA_08361	7.68e-54	180.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,1S9NJ@1236|Gammaproteobacteria,1X5C8@135614|Xanthomonadales	135614|Xanthomonadales	P	COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit	-	-	1.14.12.1,1.14.15.7	ko:K00499,ko:K16319	ko00260,ko00627,ko01120,map00260,map00627,map01120	M00637	R00823,R00825,R07409	RC00087,RC00192	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
k59_863599_2	765912.Thimo_2753	9.81e-65	201.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,1RQ0Y@1236|Gammaproteobacteria,1WXYG@135613|Chromatiales	135613|Chromatiales	Q	PFAM Mammalian cell entry related domain protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_1517509_1	717785.HYPMC_1118	9.1e-55	182.0	29APY@1|root,2ZXPR@2|Bacteria,1R817@1224|Proteobacteria,2TSBC@28211|Alphaproteobacteria,3N8C4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1849)	MA20_36210	-	-	-	-	-	-	-	-	-	-	-	DUF1849
k59_569885_1	1485545.JQLW01000006_gene476	4.4e-63	214.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria	1224|Proteobacteria	I	Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate	yfcX	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_1391435_1	471853.Bcav_2215	6.08e-96	293.0	COG0469@1|root,COG0469@2|Bacteria,2GJY8@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the pyruvate kinase family	pyk	GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_863609_1	1121456.ATVA01000014_gene729	4.35e-49	162.0	COG1636@1|root,COG1636@2|Bacteria,1MUG5@1224|Proteobacteria,42M1E@68525|delta/epsilon subdivisions,2WMR5@28221|Deltaproteobacteria,2MAS4@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queH	-	1.17.99.6	ko:K09765	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF208
k59_1108915_1	335543.Sfum_2077	1.49e-26	107.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42P0M@68525|delta/epsilon subdivisions,2WJMC@28221|Deltaproteobacteria,2MR1W@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	AMP-dependent synthetase and ligase	-	-	6.2.1.1,6.2.1.32	ko:K01895,ko:K08295	ko00010,ko00620,ko00627,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00627,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R00982,R01354	RC00004,RC00012,RC00043,RC00070,RC00174,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_1451669_1	367299.JOEE01000003_gene2826	1.17e-46	158.0	COG2345@1|root,COG2345@2|Bacteria,2IR6V@201174|Actinobacteria,4FGMS@85021|Intrasporangiaceae	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_IclR
k59_1799455_1	717785.HYPMC_1744	2.94e-61	205.0	COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,2TRM3@28211|Alphaproteobacteria,3N6ST@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_217984_1	1121372.AULK01000004_gene1320	2.19e-09	63.5	COG1609@1|root,COG1609@2|Bacteria,2GNVD@201174|Actinobacteria,4FMFK@85023|Microbacteriaceae	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
k59_1517553_1	1123073.KB899241_gene2741	3.49e-33	132.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1X31Q@135614|Xanthomonadales	135614|Xanthomonadales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_159776_1	629773.AORY01000015_gene1237	3.05e-18	85.5	COG0741@1|root,COG0741@2|Bacteria,1MUMA@1224|Proteobacteria,2TSA5@28211|Alphaproteobacteria,2K190@204457|Sphingomonadales	204457|Sphingomonadales	M	transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_1035724_2	1206733.BAGC01000041_gene1874	1.82e-16	78.6	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4FXF4@85025|Nocardiaceae	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1744416_1	452652.KSE_43800	5.34e-59	196.0	COG0037@1|root,COG0037@2|Bacteria,2GJR4@201174|Actinobacteria,2M26Z@2063|Kitasatospora	201174|Actinobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	GO:0008150,GO:0040007	2.4.2.8,6.3.4.19	ko:K00760,ko:K04075	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016	-	-	-	ATP_bind_3,TilS
k59_1391485_1	710696.Intca_2900	2.31e-52	166.0	COG3093@1|root,COG3093@2|Bacteria,2IR2S@201174|Actinobacteria,4FHGX@85021|Intrasporangiaceae	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	higA	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
k59_1216410_2	314607.KB13_603	0.000113	45.8	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2VIYX@28216|Betaproteobacteria,1KPW2@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Nitrite and sulphite reductase 4Fe-4S domain	cysI	-	1.8.1.2,1.8.7.1	ko:K00381,ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858,R00859,R03600	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_628861_1	935839.JAGJ01000003_gene1380	4.55e-24	100.0	2E4C2@1|root,32Z7M@2|Bacteria,2IFS5@201174|Actinobacteria,4F4VX@85017|Promicromonosporaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3093)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3093
k59_1451703_1	1031711.RSPO_c00818	8.91e-34	127.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,1K4Q2@119060|Burkholderiaceae	28216|Betaproteobacteria	NU	twitching motility protein	pilU	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_1451703_2	1122201.AUAZ01000015_gene729	3.92e-11	65.1	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,46AEQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	Type II/IV secretion system protein	uptC	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_1686671_1	935839.JAGJ01000033_gene137	0.0	1019.0	COG1674@1|root,COG1716@1|root,COG1674@2|Bacteria,COG1716@2|Bacteria,2GJBR@201174|Actinobacteria,4F3NK@85017|Promicromonosporaceae	201174|Actinobacteria	DT	FtsK/SpoIIIE family	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_SpoIIIE,Yop-YscD_cpl
k59_1035745_1	1385518.N798_05720	2.83e-64	200.0	COG0622@1|root,COG0622@2|Bacteria,2IFVB@201174|Actinobacteria,4FGEM@85021|Intrasporangiaceae	201174|Actinobacteria	S	Calcineurin-like phosphoesterase superfamily domain	ysnB	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
k59_1035745_2	2074.JNYD01000007_gene2036	6.25e-09	53.9	COG2388@1|root,COG2388@2|Bacteria,2GQNP@201174|Actinobacteria,4E6IW@85010|Pseudonocardiales	201174|Actinobacteria	S	GCN5-related N-acetyl-transferase	-	-	-	ko:K06975	-	-	-	-	ko00000	-	-	-	Acetyltransf_CG
k59_746770_1	1232437.KL661965_gene3270	6.12e-111	337.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MJNF@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_1152411_2	1333856.L686_01035	1.21e-16	80.1	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1Z0AH@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_1517599_1	1396141.BATP01000039_gene1364	1.84e-23	101.0	COG2143@1|root,COG2143@2|Bacteria,46Z6E@74201|Verrucomicrobia,2IW7D@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	Thioredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_7
k59_1625527_1	398580.Dshi_1554	9.68e-92	275.0	COG3622@1|root,COG3622@2|Bacteria,1MV53@1224|Proteobacteria,2TSVI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the hyi family	ygbM	-	5.3.1.35	ko:K22131	-	-	-	-	ko00000,ko01000	-	-	-	AP_endonuc_2
k59_336106_1	95619.PM1_0230135	7.88e-40	147.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria	1224|Proteobacteria	L	transposase IS116 IS110 IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_628880_1	261292.Nit79A3_1078	2.72e-43	162.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VHNB@28216|Betaproteobacteria,371VU@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Belongs to the helicase family. UvrD subfamily	addA	-	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1283421_1	243233.MCA1458	5.83e-143	414.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,1XE38@135618|Methylococcales	135618|Methylococcales	T	PFAM PhoH-like protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_1283421_2	1117315.AHCA01000003_gene235	1.29e-18	85.5	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,2Q0P3@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_1108997_2	1123284.KB899049_gene1823	5.15e-22	95.5	COG5421@1|root,COG5421@2|Bacteria,1TPAA@1239|Firmicutes,4HDFR@91061|Bacilli,26PAP@186821|Sporolactobacillaceae	91061|Bacilli	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_452775_1	1304865.JAGF01000001_gene1991	1.29e-72	228.0	COG1105@1|root,COG1105@2|Bacteria,2GK7E@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the carbohydrate kinase PfkB family	fruK	-	2.7.1.11,2.7.1.56	ko:K00882,ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R02071,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
k59_1517638_1	384765.SIAM614_07663	9.99e-101	307.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2TRMA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	urtB	-	-	ko:K11960	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
k59_863705_1	316278.SynRCC307_1125	2.91e-36	136.0	COG0540@1|root,COG0540@2|Bacteria,1GMD7@1117|Cyanobacteria,1GYW3@1129|Synechococcus	1117|Cyanobacteria	F	Belongs to the ATCase OTCase family	-	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_1519357_1	713586.KB900536_gene1624	6.1e-31	114.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	yafP	-	-	ko:K03830	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
k59_1392809_1	765911.Thivi_3994	1.76e-81	246.0	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,1RMQ2@1236|Gammaproteobacteria,1WXB5@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
k59_1626873_1	393595.ABO_0785	1.14e-83	278.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1XH4B@135619|Oceanospirillales	135619|Oceanospirillales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_1110614_1	1121957.ATVL01000008_gene4409	9.82e-52	185.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,47UBJ@768503|Cytophagia	976|Bacteroidetes	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_1568735_1	1265313.HRUBRA_01483	1.03e-77	245.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,1J4SM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Permease	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_1568735_2	338966.Ppro_2750	3.77e-05	47.4	COG1132@1|root,COG1132@2|Bacteria,1MVJD@1224|Proteobacteria,42PP5@68525|delta/epsilon subdivisions,2WNMV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM ABC transporter	-	-	-	ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1	-	-	ABC_membrane,ABC_tran
k59_1519380_1	590998.Celf_2431	5.83e-135	403.0	COG4988@1|root,COG4988@2|Bacteria,2I2DP@201174|Actinobacteria,4F1V8@85016|Cellulomonadaceae	201174|Actinobacteria	V	TIGRFAM ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD	cydD	-	-	ko:K16013	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.129	-	-	ABC_membrane,ABC_tran
k59_1153599_1	472759.Nhal_0731	1.28e-19	88.2	COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,1RMF1@1236|Gammaproteobacteria,1WXIP@135613|Chromatiales	135613|Chromatiales	E	Belongs to the agmatine deiminase family	aguA	-	-	-	-	-	-	-	-	-	-	-	PAD_porph
k59_1153599_2	379731.PST_2645	3.4e-13	67.0	2ENKU@1|root,33G87@2|Bacteria,1NMH6@1224|Proteobacteria,1SGDI@1236|Gammaproteobacteria,1Z35K@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1519386_1	1126627.BAWE01000005_gene6111	4.78e-09	64.7	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_1037067_1	1048339.KB913029_gene2475	7.05e-62	199.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4ES7T@85013|Frankiales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_1153603_1	640081.Dsui_1152	1.19e-07	53.5	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2VKZS@28216|Betaproteobacteria,2KUS6@206389|Rhodocyclales	206389|Rhodocyclales	C	Nickel-dependent hydrogenase	hoxC	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_1153603_2	439235.Dalk_2282	8.16e-20	89.7	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WKC0@28221|Deltaproteobacteria,2MI11@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K10819	-	-	-	-	ko00000,ko01000	-	-	-	HATPase_c,HisKA,PAS_8,PAS_9,sCache_3_2
k59_1217711_2	1304865.JAGF01000001_gene3515	6.71e-80	252.0	COG1926@1|root,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria	201174|Actinobacteria	Q	phosphoribosyltransferase	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
k59_630092_1	1134474.O59_002167	2.14e-23	99.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,1RQ65@1236|Gammaproteobacteria,1FGED@10|Cellvibrio	1236|Gammaproteobacteria	O	Uncharacterized protein family (UPF0051)	sufB	GO:0003674,GO:0005488,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840	-	ko:K09014	-	-	-	-	ko00000	-	-	iAPECO1_1312.APECO1_760,iECH74115_1262.ECH74115_2397,iECSF_1327.ECSF_1543,iECSP_1301.ECSP_2250,iUTI89_1310.UTI89_C1875,ic_1306.c2078	UPF0051
k59_1745699_1	1244869.H261_07468	5.52e-58	194.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TUIC@28211|Alphaproteobacteria,2JQGG@204441|Rhodospirillales	204441|Rhodospirillales	P	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component	-	-	-	ko:K15578	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16.1	-	-	ABC_tran
k59_748138_1	985255.APHJ01000021_gene1241	3.51e-38	147.0	COG1538@1|root,COG3696@1|root,COG1538@2|Bacteria,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,1IJ7V@117743|Flavobacteriia,2P787@244698|Gillisia	976|Bacteroidetes	P	AcrB/AcrD/AcrF family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran,OEP
k59_1285443_1	876269.ARWA01000001_gene1935	9.06e-29	130.0	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3NBW4@45404|Beijerinckiaceae	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	3.4.24.40	ko:K01406,ko:K07004	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CBM60,HemolysinCabind,P_proprotein,Peptidase_M10_C,Peptidase_S8
k59_1153614_1	935839.JAGJ01000020_gene107	1.26e-47	157.0	COG0853@1|root,COG0853@2|Bacteria,2IHTC@201174|Actinobacteria,4F4BT@85017|Promicromonosporaceae	201174|Actinobacteria	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	GO:0003674,GO:0003824,GO:0004068,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006523,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0030312,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
k59_1153614_2	1385518.N798_13670	2.71e-80	256.0	COG0029@1|root,COG0029@2|Bacteria,2I2IJ@201174|Actinobacteria,4FE43@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16,2.4.2.19	ko:K00278,ko:K00767	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481,R03348	RC00006,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1519415_1	187272.Mlg_0365	4.03e-08	53.1	COG3103@1|root,COG4991@2|Bacteria,1MX7M@1224|Proteobacteria,1RS74@1236|Gammaproteobacteria,1WY3A@135613|Chromatiales	135613|Chromatiales	T	SH3 domain	-	-	-	ko:K07184	-	-	-	-	ko00000	-	-	-	SH3_3
k59_1519415_2	546264.NEIFLAOT_01323	3.41e-70	233.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,2KPPB@206351|Neisseriales	206351|Neisseriales	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_453971_1	1304865.JAGF01000001_gene3585	5.85e-113	346.0	COG0339@1|root,COG0339@2|Bacteria,2GM2Z@201174|Actinobacteria	201174|Actinobacteria	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	dcp	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_1757050_1	396588.Tgr7_2774	5.69e-100	305.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1WWPJ@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
k59_641271_1	1380380.JIAX01000008_gene1799	1.8e-114	348.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TTBG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Chloride channel	clcA	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	Voltage_CLC
k59_465803_1	1232410.KI421420_gene3140	5.04e-28	107.0	2E9HQ@1|root,333QT@2|Bacteria,1N8T3@1224|Proteobacteria,42VQK@68525|delta/epsilon subdivisions,2WRJ5@28221|Deltaproteobacteria,43VXM@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_465807_1	272943.RSP_2559	3.06e-50	179.0	COG1132@1|root,COG1132@2|Bacteria,1MVJD@1224|Proteobacteria,2U2HD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG1132 ABC-type multidrug transport system, ATPase and permease components	-	-	-	ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1	-	-	ABC_membrane,ABC_tran
k59_809003_1	631362.Thi970DRAFT_00706	1.47e-111	348.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
k59_1701767_2	760568.Desku_0027	9.41e-61	193.0	COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,2612W@186807|Peptococcaceae	186801|Clostridia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
k59_465833_1	1260251.SPISAL_00245	3.01e-39	141.0	COG1192@1|root,COG1192@2|Bacteria,1QWQB@1224|Proteobacteria,1T3RE@1236|Gammaproteobacteria,1X2QA@135613|Chromatiales	135613|Chromatiales	D	Involved in chromosome partitioning	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_232565_1	765911.Thivi_0744	3.13e-70	235.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1WXPB@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_174755_1	313628.LNTAR_24059	1.39e-66	219.0	COG0111@1|root,COG0111@2|Bacteria	2|Bacteria	EH	4-phosphoerythronate dehydrogenase activity	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_349826_1	497321.C664_07268	4.42e-95	281.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VK6R@28216|Betaproteobacteria,2KVYG@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4
k59_1701785_1	1049564.TevJSym_aa00470	1.09e-142	426.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,1J4KB@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	nirB	-	1.18.1.1,1.7.1.15	ko:K00362,ko:K05297	ko00071,ko00910,ko01120,map00071,map00910,map01120	M00530	R00787,R02000	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Rieske_2
k59_1231550_1	1121924.ATWH01000021_gene3327	6.94e-81	268.0	COG0637@1|root,COG1554@1|root,COG0637@2|Bacteria,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4FM83@85023|Microbacteriaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 65 central catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2
k59_810413_2	1089547.KB913013_gene524	1.94e-13	70.9	294DM@1|root,2ZRTK@2|Bacteria,4NPQ1@976|Bacteroidetes,47R3S@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4184)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4184
k59_643008_1	593907.Celgi_2424	2.28e-120	360.0	COG0366@1|root,COG0366@2|Bacteria,2GIV1@201174|Actinobacteria,4F0PT@85016|Cellulomonadaceae	201174|Actinobacteria	G	SMART alpha amylase catalytic sub domain	treS	GO:0000023,GO:0000271,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016160,GO:0016161,GO:0016787,GO:0016798,GO:0016853,GO:0016866,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046872,GO:0047471,GO:0055114,GO:0071704,GO:0071944,GO:1901576	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	iNJ661.Rv0126	Alpha-amylase,Malt_amylase_C
k59_234414_1	1123366.TH3_10426	1.09e-38	147.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,2JPKY@204441|Rhodospirillales	204441|Rhodospirillales	CE	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
k59_468270_1	2340.JV46_05260	1.09e-95	291.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria,1J515@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Flavocytochrome c sulphide dehydrogenase, flavin-binding	fccB	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.8.2.3	ko:K17229	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2,TAT_signal
k59_583627_1	765910.MARPU_16675	6.42e-108	332.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1WWAT@135613|Chromatiales	135613|Chromatiales	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_703352_1	502025.Hoch_3531	6.96e-90	288.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIWK@28221|Deltaproteobacteria,2YU9H@29|Myxococcales	28221|Deltaproteobacteria	CP	Domain of unknown function (DUF4040)	mrpA	-	-	ko:K05559,ko:K05565	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
k59_523994_1	1187851.A33M_1578	5.05e-13	68.9	COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,2TSKC@28211|Alphaproteobacteria,3FDRP@34008|Rhodovulum	28211|Alphaproteobacteria	P	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP	bchL	-	1.3.7.7	ko:K04037	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06282	RC01008	ko00000,ko00001,ko01000	-	-	-	Fer4_NifH
k59_523994_2	768671.ThimaDRAFT_1072	1.25e-60	207.0	COG1429@1|root,COG1429@2|Bacteria,1MU5W@1224|Proteobacteria,1RQED@1236|Gammaproteobacteria,1WWVH@135613|Chromatiales	135613|Chromatiales	H	CobN magnesium chelatase	bchH	-	6.6.1.1	ko:K03403	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	CobN-Mg_chel,DUF3479
k59_1407461_1	767434.Fraau_1806	1.92e-82	256.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1X46A@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
k59_234432_1	443144.GM21_3331	2.44e-94	296.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1814367_1	765912.Thimo_0432	8.36e-121	368.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1407466_1	1485544.JQKP01000015_gene2087	9.44e-35	136.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2VHKJ@28216|Betaproteobacteria,44VU4@713636|Nitrosomonadales	28216|Betaproteobacteria	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_810452_1	94122.Shewana3_3196	7.08e-32	124.0	COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,2QAZ1@267890|Shewanellaceae	1236|Gammaproteobacteria	O	PFAM AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_468303_1	765911.Thivi_2349	6.07e-108	316.0	COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,1S37E@1236|Gammaproteobacteria,1WWWB@135613|Chromatiales	135613|Chromatiales	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_1056655_1	1217718.ALOU01000016_gene3187	9.26e-17	79.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2VHBB@28216|Betaproteobacteria,1K01J@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	hemN2	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_1056655_2	1211115.ALIQ01000208_gene3368	1.08e-40	147.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria,3N9R5@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Citrate synthase, C-terminal domain	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_468318_1	1123354.AUDR01000017_gene77	2.14e-52	180.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,1KSGF@119069|Hydrogenophilales	119069|Hydrogenophilales	H	Mur ligase family, glutamate ligase domain	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_468327_1	596151.DesfrDRAFT_0647	9.79e-23	102.0	COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,42QJC@68525|delta/epsilon subdivisions,2WPI2@28221|Deltaproteobacteria,2M9VY@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_10,TPR_16,TPR_19,TPR_4,TPR_8
k59_703396_1	1029824.AFID01000001_gene2152	7.78e-06	54.3	COG3266@1|root,COG3266@2|Bacteria,2I2EC@201174|Actinobacteria,1W81Z@1268|Micrococcaceae	201174|Actinobacteria	S	Domain of Unknown Function (DUF349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF349
k59_1641199_1	643648.Slip_2357	4.66e-05	46.6	COG0517@1|root,COG0517@2|Bacteria,1V0XU@1239|Firmicutes,24I2P@186801|Clostridia,42JYZ@68298|Syntrophomonadaceae	186801|Clostridia	S	PFAM CBS domain containing protein	acuB	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
k59_1056699_1	2340.JV46_05290	3.46e-84	266.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J595@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	cation transport ATPase	ccoI	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_351809_1	870187.Thini_0322	2.91e-77	254.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,460EP@72273|Thiotrichales	72273|Thiotrichales	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_643101_1	1121937.AUHJ01000002_gene3417	2.81e-38	149.0	COG2200@1|root,COG4191@1|root,COG2200@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg
k59_1168556_1	985054.JQEZ01000004_gene798	4.09e-85	271.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2TQJ7@28211|Alphaproteobacteria,4NAXP@97050|Ruegeria	28211|Alphaproteobacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_1641215_1	1123236.KB899377_gene312	8.59e-19	84.7	COG2133@1|root,COG2133@2|Bacteria,1R74P@1224|Proteobacteria,1RSG0@1236|Gammaproteobacteria,4676D@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
k59_1641215_2	392500.Swoo_4378	5.79e-84	277.0	28HKI@1|root,2Z7VC@2|Bacteria,1MW0I@1224|Proteobacteria,1RQ5H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1758810_1	224911.27349556	8.59e-12	69.7	2919Q@1|root,2ZNWS@2|Bacteria,1NAF5@1224|Proteobacteria,2U3AC@28211|Alphaproteobacteria,3JVYY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	MA20_20955	-	-	-	-	-	-	-	-	-	-	-	-
k59_810499_1	571166.KI421509_gene3588	1.07e-91	278.0	COG5361@1|root,COG5361@2|Bacteria,1NZZJ@1224|Proteobacteria,2TV8A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_468385_1	391625.PPSIR1_23134	9.16e-31	117.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42N78@68525|delta/epsilon subdivisions,2WM0M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	mechanosensitive ion channel	mscS-2	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_643111_1	381666.H16_A0257	6.78e-38	139.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria,1K3UE@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
k59_643111_2	1244083.CSUNSWCD_2044	1.44e-19	85.1	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2YMDK@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
k59_1466765_1	114615.BRADO4221	2.15e-114	340.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2TQW9@28211|Alphaproteobacteria,3JTRP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Beta-eliminating lyase	metY	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003961,GO:0004124,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0050667,GO:0071265,GO:0071266,GO:0071268,GO:0071269,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47,2.5.1.49	ko:K01738,ko:K01740	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R01287,R03601,R04859	RC00020,RC02814,RC02821,RC02848	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1168583_1	1049564.TevJSym_at00390	8.91e-137	402.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1J4IR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663	-	ko:K03688	-	-	-	-	ko00000	-	-	iYL1228.KPN_04331	ABC1
k59_468407_1	472759.Nhal_0484	3.9e-164	481.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1WWDS@135613|Chromatiales	135613|Chromatiales	M	Catalyzes cross-linking of the peptidoglycan cell wall at the division septum	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
k59_234526_1	743720.Psefu_3515	2.58e-51	183.0	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,1YWIN@136845|Pseudomonas putida group	1236|Gammaproteobacteria	I	Belongs to the GPAT DAPAT family	plsB	GO:0003674,GO:0003824,GO:0004366,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006629,GO:0006631,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0031224,GO:0031226,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iECs_1301.ECs5024,iG2583_1286.G2583_4866	Acyltransferase
k59_703451_1	243233.MCA2541	7.41e-138	404.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XDX4@135618|Methylococcales	135618|Methylococcales	T	Nitrogen regulation	-	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_234531_3	1120968.AUBX01000014_gene2484	0.000619	42.7	COG0604@1|root,COG0604@2|Bacteria,4NHHT@976|Bacteroidetes,47N64@768503|Cytophagia	976|Bacteroidetes	C	COGs COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_N_2,ADH_zinc_N_2
k59_1168610_1	35128.Thaps10331	3.38e-08	60.8	2CZH9@1|root,2SACR@2759|Eukaryota,2XDZJ@2836|Bacillariophyta	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_703457_1	498211.CJA_3477	4.26e-68	214.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,1FFV7@10|Cellvibrio	1236|Gammaproteobacteria	D	Necessary for normal cell division and for the maintenance of normal septation	engB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
k59_524126_1	1149133.ppKF707_0221	6.06e-26	98.6	COG2929@1|root,COG2929@2|Bacteria,1MZKJ@1224|Proteobacteria,1S984@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
k59_524126_2	237368.SCABRO_01789	6.12e-38	127.0	2E3TC@1|root,32YQV@2|Bacteria	2|Bacteria	S	copG family	-	-	-	-	-	-	-	-	-	-	-	-	CopG_antitoxin
k59_234558_1	713586.KB900536_gene970	1.54e-37	141.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,1WW8I@135613|Chromatiales	135613|Chromatiales	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_1641267_2	686578.AFFX01000005_gene4348	4.86e-12	70.5	COG0609@1|root,COG4559@1|root,COG0609@2|Bacteria,COG4559@2|Bacteria	2|Bacteria	P	heme-transporting ATPase activity	hmuV	GO:0000041,GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0008150,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0030001,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085	1.14.15.20,3.6.3.33,3.6.3.34	ko:K02013,ko:K02015,ko:K06074,ko:K21480	ko00860,ko01100,ko01110,ko02010,map00860,map01100,map01110,map02010	M00240,M00241	R11579	RC01270	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.13,3.A.1.14	-	-	ABC_tran,FecCD
k59_1641269_2	1286170.RORB6_22960	3.27e-08	57.4	COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,1RN29@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box) 5'-GGA TG GA-3'	acoK	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,AAA_25,GerE,TPR_12
k59_1758883_1	697282.Mettu_3502	5.37e-30	122.0	COG3290@1|root,COG3447@1|root,COG3614@1|root,COG3920@1|root,COG3290@2|Bacteria,COG3447@2|Bacteria,COG3614@2|Bacteria,COG3920@2|Bacteria,1PGPR@1224|Proteobacteria,1RX1U@1236|Gammaproteobacteria,1XGJY@135618|Methylococcales	135618|Methylococcales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_2
k59_1407562_1	765913.ThidrDRAFT_4169	3.78e-145	427.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1WWG8@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
k59_468484_1	1380356.JNIK01000016_gene3489	8.19e-29	108.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_468484_2	1380356.JNIK01000016_gene3488	5.3e-75	229.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
k59_583742_1	1049564.TevJSym_bo00200	3.59e-147	429.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1N3PN@1224|Proteobacteria,1RNS0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Nitrite reductase	nirS	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_583750_1	443144.GM21_2197	7.63e-79	247.0	COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,42N0R@68525|delta/epsilon subdivisions,2WMPF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Fer2_BFD
k59_234584_1	1121405.dsmv_2608	2.23e-93	285.0	COG0498@1|root,COG0498@2|Bacteria	2|Bacteria	E	threonine synthase activity	-	-	2.5.1.76,4.2.3.1	ko:K01733,ko:K15527	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,PALP
k59_1814596_1	1304865.JAGF01000001_gene562	4.04e-110	346.0	COG0507@1|root,COG0507@2|Bacteria,2GJRK@201174|Actinobacteria	201174|Actinobacteria	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_30,TrwC
k59_1814600_2	996637.SGM_6724	5.5e-14	70.5	COG0012@1|root,COG0012@2|Bacteria,2GIXI@201174|Actinobacteria	201174|Actinobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_524173_1	446466.Cfla_3093	3.28e-55	178.0	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,4F0JA@85016|Cellulomonadaceae	201174|Actinobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_524173_2	1380354.JIAN01000005_gene1822	2.48e-22	95.5	COG2267@1|root,COG2267@2|Bacteria,2I2IM@201174|Actinobacteria,4F0TB@85016|Cellulomonadaceae	201174|Actinobacteria	I	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_524175_1	243233.MCA2378	7.15e-31	122.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,1RPBP@1236|Gammaproteobacteria,1XET3@135618|Methylococcales	135618|Methylococcales	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
k59_1466834_1	314278.NB231_15368	4.56e-85	270.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1S48Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_1641304_1	590998.Celf_2839	7.79e-58	193.0	COG0340@1|root,COG0340@2|Bacteria,2GN8Q@201174|Actinobacteria,4F19S@85016|Cellulomonadaceae	201174|Actinobacteria	H	PFAM biotin lipoate A B protein ligase	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
k59_703535_1	1158318.ATXC01000001_gene476	1.78e-18	94.4	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,DUF3858,Transglut_core
k59_351954_1	1198232.CYCME_2166	8.01e-36	135.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,45ZPB@72273|Thiotrichales	72273|Thiotrichales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_63410_1	666681.M301_2484	1.49e-95	287.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2VMWQ@28216|Betaproteobacteria,2KKWQ@206350|Nitrosomonadales	206350|Nitrosomonadales	Q	BAAT / Acyl-CoA thioester hydrolase C terminal	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_179150_1	1123393.KB891333_gene2645	3.22e-109	323.0	COG1180@1|root,COG1180@2|Bacteria,1R8XY@1224|Proteobacteria,2WFUM@28216|Betaproteobacteria,1KTIG@119069|Hydrogenophilales	119069|Hydrogenophilales	O	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
k59_120522_1	471853.Bcav_3479	1.76e-43	153.0	COG0679@1|root,COG0679@2|Bacteria,2GNIA@201174|Actinobacteria	201174|Actinobacteria	S	auxin efflux carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
k59_885292_1	1120949.KB903356_gene8498	1.89e-21	92.0	COG0702@1|root,COG0702@2|Bacteria,2GK1A@201174|Actinobacteria,4DA62@85008|Micromonosporales	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
k59_885292_2	1234364.AMSF01000080_gene3020	4.3e-44	161.0	COG0642@1|root,COG0642@2|Bacteria,1N6S8@1224|Proteobacteria,1RRCJ@1236|Gammaproteobacteria,1X67V@135614|Xanthomonadales	135614|Xanthomonadales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HisKA
k59_707596_1	1313265.JNIE01000004_gene422	3.08e-35	130.0	COG1423@1|root,COG1423@2|Bacteria	2|Bacteria	L	RNA ligase	-	-	6.5.1.1	ko:K07468	-	-	R00381	RC00005	ko00000,ko01000	-	-	-	RNA_ligase
k59_1060079_1	1408418.JNJH01000024_gene24	4.74e-46	159.0	COG2267@1|root,COG2267@2|Bacteria,1NVD4@1224|Proteobacteria,2URW5@28211|Alphaproteobacteria,2JWPZ@204441|Rhodospirillales	204441|Rhodospirillales	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_885296_1	1435356.Y013_01655	1.13e-69	219.0	28P5T@1|root,2ZC0N@2|Bacteria,2GP34@201174|Actinobacteria,4FX63@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1118158_1	999419.HMPREF1077_00448	4.71e-16	72.8	COG0222@1|root,COG0222@2|Bacteria,4NQAQ@976|Bacteroidetes,2FSJH@200643|Bacteroidia,22Y4T@171551|Porphyromonadaceae	976|Bacteroidetes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
k59_1118158_2	765911.Thivi_4194	9.12e-33	129.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1235912_1	296591.Bpro_4805	1.54e-26	108.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2VJ2W@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_238258_2	1177928.TH2_15302	1.5e-12	67.8	COG2885@1|root,COG2885@2|Bacteria,1NA0J@1224|Proteobacteria,2UFTJ@28211|Alphaproteobacteria,2JU47@204441|Rhodospirillales	204441|Rhodospirillales	M	COG2885 outer membrane protein and related peptidoglycan-associated (lipo)proteins	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
k59_1177199_1	1283300.ATXB01000001_gene1792	3.19e-100	310.0	COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,1RMH4@1236|Gammaproteobacteria,1XDPA@135618|Methylococcales	135618|Methylococcales	T	Histidine kinase	-	-	2.7.13.3	ko:K15011	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c
k59_4123_1	765910.MARPU_10725	4.97e-128	375.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RQ04@1236|Gammaproteobacteria,1WXUZ@135613|Chromatiales	135613|Chromatiales	U	Part of a membrane complex involved in electron transport	-	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
k59_765886_1	1108045.GORHZ_129_00050	6.5e-98	292.0	COG1266@1|root,COG1266@2|Bacteria,2GYQG@201174|Actinobacteria,4GEKG@85026|Gordoniaceae	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_1060096_1	408672.NBCG_01462	2.23e-58	196.0	COG1653@1|root,COG1653@2|Bacteria,2GJXB@201174|Actinobacteria,4DP01@85009|Propionibacteriales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10232	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1,SBP_bac_8
k59_179176_1	1131553.JIBI01000030_gene2443	2.15e-65	217.0	COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,2VJP0@28216|Betaproteobacteria,3721K@32003|Nitrosomonadales	28216|Betaproteobacteria	HJ	RimK-like ATPgrasp N-terminal domain	rimK	-	-	-	-	-	-	-	-	-	-	-	RLAN,RimK
k59_238269_1	1443125.Z962_06850	6.85e-13	73.2	COG0635@1|root,COG0635@2|Bacteria,1TUUY@1239|Firmicutes,2490N@186801|Clostridia,36GCR@31979|Clostridiaceae	186801|Clostridia	H	coproporphyrinogen III oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_63462_1	404380.Gbem_2751	1.43e-46	159.0	COG4589@1|root,COG4589@2|Bacteria,1R34Q@1224|Proteobacteria,42QTH@68525|delta/epsilon subdivisions,2WQ6V@28221|Deltaproteobacteria,43SXU@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM phosphatidate cytidylyltransferase	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
k59_1647009_1	642492.Clole_2841	4.81e-23	98.6	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia	186801|Clostridia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_1235929_1	471856.Jden_0931	1.25e-103	315.0	COG0488@1|root,COG0488@2|Bacteria,2GKBQ@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	yjjK	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
k59_765895_1	717785.HYPMC_1606	1.81e-38	137.0	2CCJC@1|root,31PRJ@2|Bacteria,1R6D1@1224|Proteobacteria,2TV8P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_885339_2	443152.MDG893_08075	3.11e-43	159.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,463XW@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0488 ATPase components of ABC transporters with duplicated ATPase domains	uup	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_1000773_1	290397.Adeh_0721	6.32e-73	242.0	COG0568@1|root,COG1196@1|root,COG0568@2|Bacteria,COG1196@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2YUHI@29|Myxococcales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1353290_1	870187.Thini_0903	8.13e-40	149.0	COG0469@1|root,COG0469@2|Bacteria,1NNNX@1224|Proteobacteria,1RYF5@1236|Gammaproteobacteria,461PZ@72273|Thiotrichales	72273|Thiotrichales	G	Pyruvate kinase, barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PK
k59_1235935_1	1265505.ATUG01000002_gene2460	2.79e-62	208.0	COG0151@1|root,COG0151@2|Bacteria,1NTMF@1224|Proteobacteria,42YB9@68525|delta/epsilon subdivisions,2WTMZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain	-	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A
k59_1705536_1	1286106.MPL1_04412	1.64e-120	362.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,45ZNP@72273|Thiotrichales	72273|Thiotrichales	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_590248_1	69328.PVLB_08150	8.37e-32	123.0	2CCYB@1|root,2Z88J@2|Bacteria,1RA8X@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_590248_2	243233.MCA1309	1.56e-20	90.1	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1XE3E@135618|Methylococcales	135618|Methylococcales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003824,GO:0004654,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_648833_1	1317118.ATO8_18175	5.93e-120	355.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_413851_1	519989.ECTPHS_03662	3.33e-65	200.0	COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,1S6Y1@1236|Gammaproteobacteria,1WYCP@135613|Chromatiales	135613|Chromatiales	K	PFAM regulatory protein, MerR	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
k59_413851_3	1198232.CYCME_1813	3.2e-23	100.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,45ZNZ@72273|Thiotrichales	72273|Thiotrichales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_765896_2	1121396.KB893065_gene1642	4.93e-21	99.4	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,42P6I@68525|delta/epsilon subdivisions,2WMAF@28221|Deltaproteobacteria,2MIAS@213118|Desulfobacterales	28221|Deltaproteobacteria	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
k59_179191_1	713587.THITH_05130	1.11e-213	600.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,1WW8H@135613|Chromatiales	135613|Chromatiales	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_648836_1	1485544.JQKP01000003_gene251	6.56e-10	70.1	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria,44VR7@713636|Nitrosomonadales	28216|Betaproteobacteria	NU	pilus assembly protein FimV	fimV	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	LysM
k59_413859_1	94624.Bpet4665	4.87e-35	137.0	COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,2VMBE@28216|Betaproteobacteria,3T668@506|Alcaligenaceae	28216|Betaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_6,Fer4_7
k59_120574_1	1026882.MAMP_01361	8.69e-63	206.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,460M9@72273|Thiotrichales	72273|Thiotrichales	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_472731_1	765911.Thivi_0952	9.11e-12	64.3	COG3278@1|root,COG3278@2|Bacteria,1P8T0@1224|Proteobacteria,1T4ST@1236|Gammaproteobacteria,1WW05@135613|Chromatiales	135613|Chromatiales	O	Belongs to the heme-copper respiratory oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_472731_2	768671.ThimaDRAFT_0822	1.11e-26	100.0	COG4309@1|root,COG4309@2|Bacteria,1NHRT@1224|Proteobacteria,1SFUF@1236|Gammaproteobacteria,1WZAD@135613|Chromatiales	135613|Chromatiales	S	Uncharacterized conserved protein (DUF2249)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2249
k59_472731_3	768671.ThimaDRAFT_0823	2.78e-07	50.4	COG3945@1|root,COG3945@2|Bacteria,1N383@1224|Proteobacteria,1S89I@1236|Gammaproteobacteria,1WZ61@135613|Chromatiales	135613|Chromatiales	S	Hemerythrin HHE	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
k59_707650_2	998674.ATTE01000001_gene4300	3.14e-61	192.0	COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,1S3P6@1236|Gammaproteobacteria,460T4@72273|Thiotrichales	72273|Thiotrichales	J	binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
k59_707650_3	472759.Nhal_2405	5.72e-35	130.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1WWJA@135613|Chromatiales	135613|Chromatiales	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_63500_1	1123236.KB899377_gene109	2.82e-06	54.3	COG1711@1|root,COG1711@2|Bacteria,1RIA0@1224|Proteobacteria,1S715@1236|Gammaproteobacteria,46D7Y@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3014)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3014
k59_1470656_1	1207063.P24_14274	5.19e-67	226.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2JPV8@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1042 Acyl-CoA synthetase (NDP forming)	yfiQ	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1412023_1	399795.CtesDRAFT_PD5446	7.66e-84	261.0	COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2VJJQ@28216|Betaproteobacteria,4ACUE@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
k59_1647035_1	582899.Hden_1023	7.89e-99	293.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2TRZ2@28211|Alphaproteobacteria,3N6KN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_531536_1	1417296.U879_20765	7.69e-78	246.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2TQRI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	COG0303 Molybdopterin biosynthesis enzyme	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_63506_1	1121921.KB898710_gene531	4.17e-38	140.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	eryB	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO
k59_179205_1	290398.Csal_2062	1.98e-62	213.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1XH5W@135619|Oceanospirillales	135619|Oceanospirillales	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1529249_1	1121428.DESHY_30126___1	2.77e-29	110.0	COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,24ND7@186801|Clostridia,2629N@186807|Peptococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iHN637.CLJU_RS01195	ATP-synt_DE,ATP-synt_DE_N
k59_944144_1	1279017.AQYJ01000028_gene2362	2.11e-08	57.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,4659K@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
k59_590277_1	1304865.JAGF01000001_gene2260	1.75e-132	394.0	COG1263@1|root,COG1264@1|root,COG2190@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,COG2190@2|Bacteria,2GK6B@201174|Actinobacteria	201174|Actinobacteria	G	Pts system	bglF	-	-	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	M00271	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6	-	-	PTS_EIIA_1,PTS_EIIB,PTS_EIIC
k59_1060135_2	3847.GLYMA09G08100.1	1.35e-25	111.0	COG4870@1|root,KOG1543@2759|Eukaryota,37SFA@33090|Viridiplantae,3G8S3@35493|Streptophyta,4JNFF@91835|fabids	35493|Streptophyta	O	Belongs to the peptidase C1 family	-	GO:0000323,GO:0002376,GO:0003674,GO:0003824,GO:0004175,GO:0004197,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005773,GO:0006508,GO:0006807,GO:0006955,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0019538,GO:0030163,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.22.16	ko:K01366	ko04142,ko04210,map04142,map04210	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Inhibitor_I29,Peptidase_C1
k59_4185_1	1151122.AQYD01000007_gene665	6.33e-90	304.0	COG2911@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG4625@1|root,COG4932@1|root,COG5373@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,COG4625@2|Bacteria,COG4932@2|Bacteria,COG5373@2|Bacteria	2|Bacteria	KLT	membrane	-	-	-	ko:K02451,ko:K03832,ko:K13735,ko:K20276,ko:K21449	ko02024,ko05100,map02024,map05100	M00331	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	1.B.40.2,2.C.1.1,9.B.42	-	-	PATR,T2SSB
k59_590281_1	426117.M446_4544	0.000165	43.1	COG0765@1|root,COG0765@2|Bacteria,1MUVX@1224|Proteobacteria,2TRAT@28211|Alphaproteobacteria,1JS48@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	MA20_06175	-	-	ko:K10003	ko02010,ko02020,map02010,map02020	M00230	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.19,3.A.1.3.4	-	-	BPD_transp_1
k59_590281_2	204773.HEAR0225	1.64e-101	301.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2VHFS@28216|Betaproteobacteria,4737I@75682|Oxalobacteraceae	28216|Betaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	gltI	-	-	ko:K10001	ko02010,ko02020,map02010,map02020	M00230	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.19,3.A.1.3.4	-	-	SBP_bac_3
k59_765925_1	450380.JPSY01000001_gene653	1.4e-30	124.0	COG2120@1|root,COG3537@1|root,COG2120@2|Bacteria,COG3537@2|Bacteria	2|Bacteria	G	Alpha-1,2-mannosidase	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PIG-L,Ricin_B_lectin,VCBS
k59_1060137_2	1123355.JHYO01000008_gene2681	2.84e-153	456.0	COG2172@1|root,COG2203@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,1PFBR@1224|Proteobacteria,2U1RE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Sigma factor PP2C-like phosphatases	rsbU	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c_2,SpoIIE
k59_296750_1	1210045.ALNP01000002_gene4101	7.11e-19	85.5	COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria	201174|Actinobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
k59_296750_2	1123065.ATWL01000004_gene2731	3.02e-27	107.0	COG5512@1|root,COG5512@2|Bacteria,2GNQ4@201174|Actinobacteria	201174|Actinobacteria	S	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
k59_121489_1	1192868.CAIU01000021_gene3143	2.02e-45	157.0	COG1120@1|root,COG1120@2|Bacteria,1QPWJ@1224|Proteobacteria,2U1TK@28211|Alphaproteobacteria,43J0K@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_358424_1	1288298.rosmuc_00533	1.74e-71	234.0	COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,2VFZH@28211|Alphaproteobacteria,46PQ0@74030|Roseovarius	28211|Alphaproteobacteria	H	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,HTH_24,PUA_2
k59_945569_1	1249627.D779_3018	1.25e-22	92.0	COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,1S3XB@1236|Gammaproteobacteria,1WYGA@135613|Chromatiales	135613|Chromatiales	F	Nudix N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N_2
k59_945569_2	1123354.AUDR01000020_gene1992	3.04e-07	53.9	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VHR2@28216|Betaproteobacteria,1KRJZ@119069|Hydrogenophilales	119069|Hydrogenophilales	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_121490_1	95619.PM1_0208860	6.56e-97	309.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_1706482_1	95619.PM1_0204745	1.91e-57	189.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008033,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016070,GO:0016740,GO:0016765,GO:0019222,GO:0031323,GO:0031326,GO:0032268,GO:0033554,GO:0034248,GO:0034470,GO:0034605,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043555,GO:0044237,GO:0044238,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0051716,GO:0052381,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990497,GO:2000112,GO:2000765	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
k59_1471596_1	414996.IL38_20295	1.51e-08	56.6	COG1925@1|root,COG3412@1|root,COG1925@2|Bacteria,COG3412@2|Bacteria,2IHRN@201174|Actinobacteria,408AP@622450|Actinopolysporales	201174|Actinobacteria	G	PTS system fructose IIA component	dhaM	-	2.7.1.121	ko:K05881	ko00561,map00561	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000,ko02000	-	-	-	EIIA-man,PTS-HPr
k59_1471596_2	1304865.JAGF01000001_gene3850	5.85e-27	104.0	2EHND@1|root,33BE5@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF4233)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4233
k59_1471596_3	590998.Celf_1491	3.08e-75	227.0	COG0105@1|root,COG0105@2|Bacteria,2IFBU@201174|Actinobacteria,4F1AC@85016|Cellulomonadaceae	201174|Actinobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004518,GO:0004550,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016787,GO:0016788,GO:0018995,GO:0019205,GO:0019538,GO:0019637,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034641,GO:0036211,GO:0042025,GO:0043170,GO:0043412,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046483,GO:0046777,GO:0046939,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072527,GO:0090304,GO:0090305,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	iNJ661.Rv2445c	NDK
k59_945579_1	32057.KB217478_gene5792	4.45e-40	149.0	COG3385@1|root,COG3385@2|Bacteria,1G2W3@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_766691_1	396588.Tgr7_2764	8.05e-109	326.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1WWJH@135613|Chromatiales	135613|Chromatiales	E	peptidase M24B, X-Pro dipeptidase aminopeptidase	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_825616_1	1267005.KB911258_gene495	7.33e-95	282.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TR8D@28211|Alphaproteobacteria,3N6FP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
k59_532437_1	28229.ND2E_1266	1.15e-41	145.0	COG2703@1|root,COG2703@2|Bacteria,1PDVZ@1224|Proteobacteria,1SGZA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Hemerythrin HHE cation binding domain	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
k59_1236938_1	207559.Dde_0402	1.01e-53	182.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42NHV@68525|delta/epsilon subdivisions,2WJBA@28221|Deltaproteobacteria,2M9AE@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	acrA	-	-	ko:K03585,ko:K18145,ko:K18295	ko01501,ko01503,map01501,map01503	M00639,M00646,M00647,M00649,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,2.A.6.2.40,8.A.1,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23
k59_1413008_1	713586.KB900536_gene2995	2.26e-122	374.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_532442_1	290399.Arth_2763	2.5e-10	60.5	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,1W88Q@1268|Micrococcaceae	201174|Actinobacteria	H	Aminotransferase	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_303298_1	472759.Nhal_3124	3.86e-15	70.5	COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,1S4YE@1236|Gammaproteobacteria,1WYAQ@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type IV pilus assembly PilZ	-	-	-	ko:K02676	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilZ
k59_303298_2	42565.FP66_12900	3.26e-28	116.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,1RNYA@1236|Gammaproteobacteria,1XIFW@135619|Oceanospirillales	135619|Oceanospirillales	L	DNA polymerase III subunit delta	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
k59_1834220_1	1304885.AUEY01000005_gene854	2.65e-67	211.0	COG1971@1|root,COG1971@2|Bacteria,1NWBY@1224|Proteobacteria,42RE2@68525|delta/epsilon subdivisions,2WNEN@28221|Deltaproteobacteria,2MK2I@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Probably functions as a manganese efflux pump	mntP	-	-	-	-	-	-	-	-	-	-	-	Mntp
k59_1834220_2	1249627.D779_3171	5.23e-07	52.8	COG0428@1|root,COG0428@2|Bacteria,1MWEZ@1224|Proteobacteria,1RNXU@1236|Gammaproteobacteria,1WWUH@135613|Chromatiales	135613|Chromatiales	P	ZIP Zinc transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
k59_953858_1	1267005.KB911256_gene1900	3.73e-43	161.0	COG2982@1|root,COG2982@2|Bacteria,1MUNH@1224|Proteobacteria,2TT0W@28211|Alphaproteobacteria,3N7AH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	AsmA family	asmA	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
k59_1770316_1	335543.Sfum_0020	3.36e-140	422.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2MQ92@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K01338,ko:K04076	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Lon_C
k59_127618_1	1352941.M877_05595	7.68e-28	116.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.17.1.9,1.6.5.3	ko:K00122,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_655929_1	670307.HYPDE_30508	1.79e-18	83.2	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,2TTQS@28211|Alphaproteobacteria,3N6MR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	Short-chain dehydrogenase reductase SDR	MA20_27940	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575	-	-	-	-	-	-	-	-	-	-	adh_short
k59_655929_2	1267005.KB911258_gene585	4.76e-28	108.0	COG1235@1|root,COG1235@2|Bacteria,1MVJH@1224|Proteobacteria,2TQQN@28211|Alphaproteobacteria,3N6M2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Beta-lactamase superfamily domain	phnP	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
k59_73122_1	1297569.MESS2_1300006	2.99e-105	310.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2TQYF@28211|Alphaproteobacteria,43J2I@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10,Fer4_17,Fer4_8
k59_1244931_1	1137799.GZ78_04645	3.66e-22	99.4	COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1RMXU@1236|Gammaproteobacteria,1XI4B@135619|Oceanospirillales	1236|Gammaproteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21.2	-	-	SSF
k59_16615_1	102129.Lepto7375DRAFT_2522	9.95e-17	89.0	COG3064@1|root,COG3064@2|Bacteria,1GQ9D@1117|Cyanobacteria,1HHWZ@1150|Oscillatoriales	1117|Cyanobacteria	M	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157
k59_1711909_1	530564.Psta_1821	1.56e-25	107.0	COG3119@1|root,COG3119@2|Bacteria,2IX0Y@203682|Planctomycetes	203682|Planctomycetes	P	PFAM sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1654169_1	519989.ECTPHS_01549	2.59e-94	286.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1WVX9@135613|Chromatiales	135613|Chromatiales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_1654169_2	522306.CAP2UW1_4043	4.47e-19	83.6	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2VVPX@28216|Betaproteobacteria,1KR6J@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	-	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_1654169_3	1123517.JOMR01000001_gene3	1.28e-18	79.7	COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,1SCC7@1236|Gammaproteobacteria,461D2@72273|Thiotrichales	72273|Thiotrichales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_1654169_4	1266914.ATUK01000011_gene2311	5.98e-18	78.2	COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,1SFNP@1236|Gammaproteobacteria,1X2FC@135613|Chromatiales	135613|Chromatiales	E	Phosphoribosyl-ATP pyrophosphohydrolase	hisE	-	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
k59_953871_1	1123065.ATWL01000009_gene999	1.29e-135	412.0	COG1205@1|root,COG1205@2|Bacteria,2GJJ6@201174|Actinobacteria	201174|Actinobacteria	L	dead DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
k59_1244937_1	1123399.AQVE01000003_gene2155	3.78e-35	130.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,4625S@72273|Thiotrichales	72273|Thiotrichales	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_1419360_1	1111732.AZOD01000013_gene1967	5.98e-54	184.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1X453@135614|Xanthomonadales	135614|Xanthomonadales	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
k59_1419360_2	760011.Spico_0376	1.14e-09	58.5	COG2270@1|root,COG2270@2|Bacteria,2J9X6@203691|Spirochaetes	203691|Spirochaetes	S	Vacuole effluxer Atg22 like	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_1419362_1	192952.MM_0357	7.58e-11	62.0	COG0334@1|root,arCOG01352@2157|Archaea,2XU0F@28890|Euryarchaeota,2N92V@224756|Methanomicrobia	28890|Euryarchaeota	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_1244946_1	1122962.AULH01000005_gene2675	7.85e-07	52.8	COG4319@1|root,COG4319@2|Bacteria,1N8K3@1224|Proteobacteria,2UXUT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
k59_771462_2	243233.MCA3076	1.34e-35	133.0	COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,1RP5U@1236|Gammaproteobacteria,1XEHX@135618|Methylococcales	135618|Methylococcales	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_420601_1	700598.Niako_3070	4.21e-63	213.0	COG1529@1|root,COG1529@2|Bacteria,4NFFU@976|Bacteroidetes,1IR1H@117747|Sphingobacteriia	976|Bacteroidetes	C	PFAM Aldehyde oxidase xanthine dehydrogenase, molybdopterin binding	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_1479985_1	446471.Xcel_2799	4.12e-35	132.0	COG1609@1|root,COG1609@2|Bacteria,2GJBJ@201174|Actinobacteria,4F5JR@85017|Promicromonosporaceae	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
k59_16644_1	96561.Dole_0706	7.54e-112	331.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2MHTQ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_1306069_1	405948.SACE_0947	2.58e-16	82.4	COG1609@1|root,COG1609@2|Bacteria,2GNVD@201174|Actinobacteria,4DX4F@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
k59_1006402_1	883.DvMF_0554	7.12e-36	142.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,42MPS@68525|delta/epsilon subdivisions,2WIUD@28221|Deltaproteobacteria,2M8H0@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_655956_1	317025.Tcr_0347	4.06e-50	168.0	COG0625@1|root,COG0625@2|Bacteria,1RD2G@1224|Proteobacteria,1S3TT@1236|Gammaproteobacteria,460NA@72273|Thiotrichales	72273|Thiotrichales	O	Glutathione S-transferase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_N_3
k59_1419374_1	621372.ACIH01000236_gene1891	4.3e-05	47.0	COG1396@1|root,COG1396@2|Bacteria,1VGAT@1239|Firmicutes,4HYM3@91061|Bacilli,26YRA@186822|Paenibacillaceae	91061|Bacilli	K	Helix-turn-helix domain	M1-354	-	-	-	-	-	-	-	-	-	-	-	HTH_3
k59_1244965_1	290340.AAur_1769	2.16e-17	80.5	COG1294@1|root,COG1294@2|Bacteria,2GMFV@201174|Actinobacteria,1W7KJ@1268|Micrococcaceae	201174|Actinobacteria	C	Cytochrome d ubiquinol oxidase, subunit II	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
k59_1771271_1	631454.N177_3991	7.02e-70	223.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Serine-pyruvate aminotransferase archaeal aspartate aminotransferase	sgaA	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_252202_1	1267005.KB911255_gene3019	6.66e-48	166.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,2TQY4@28211|Alphaproteobacteria,3N67A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Peptidase dimerisation domain	MA20_15735	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_252202_2	266779.Meso_1972	2.59e-19	86.7	COG3719@1|root,COG3719@2|Bacteria,1PTUN@1224|Proteobacteria,2TQUU@28211|Alphaproteobacteria,43JN6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Belongs to the RNase T2 family	rns	-	3.1.27.1,3.1.27.6	ko:K01166,ko:K01169	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_T2
k59_896268_1	981327.F925_00942	3.57e-84	269.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,3NIPR@468|Moraxellaceae	1236|Gammaproteobacteria	I	Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate	fadB	GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8	ko:K01782,ko:K01825	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	iLF82_1304.LF82_0614,iNRG857_1313.NRG857_19200	3HCDH,3HCDH_N,ECH_1
k59_1771281_1	396588.Tgr7_0207	1.51e-89	269.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,1WWWY@135613|Chromatiales	135613|Chromatiales	D	Belongs to the TtcA family	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
k59_1835614_1	446469.Sked_35260	6.9e-87	264.0	COG0586@1|root,COG0586@2|Bacteria,2GKGR@201174|Actinobacteria	201174|Actinobacteria	I	Pfam SNARE associated Golgi protein	dedA	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
k59_1835614_2	357808.RoseRS_0014	2.1e-52	186.0	COG0366@1|root,COG0366@2|Bacteria,2G5NW@200795|Chloroflexi,376G5@32061|Chloroflexia	32061|Chloroflexia	G	SMART alpha amylase, catalytic sub domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
k59_1420447_1	314278.NB231_16288	5.54e-14	70.5	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,1WW0C@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_1420447_2	1384056.N787_01505	1.5e-40	147.0	COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,1X361@135614|Xanthomonadales	135614|Xanthomonadales	G	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane	lapB	-	-	ko:K19804	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_7
k59_18560_1	765910.MARPU_13565	3.02e-63	202.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,1S22I@1236|Gammaproteobacteria,1WWHZ@135613|Chromatiales	135613|Chromatiales	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
k59_304256_1	335543.Sfum_3079	8.74e-49	169.0	COG0620@1|root,COG0620@2|Bacteria,1R6KI@1224|Proteobacteria,42PCN@68525|delta/epsilon subdivisions,2WKT3@28221|Deltaproteobacteria,2MRM1@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1360751_1	1240349.ANGC01000022_gene3474	3.36e-24	95.1	COG2246@1|root,COG2246@2|Bacteria,2IGKV@201174|Actinobacteria,4G0RU@85025|Nocardiaceae	201174|Actinobacteria	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
k59_1360751_2	1122997.AUDD01000007_gene900	3.98e-46	154.0	COG3428@1|root,COG3428@2|Bacteria,2GK6Y@201174|Actinobacteria,4DRJ7@85009|Propionibacteriales	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
k59_187390_1	572477.Alvin_2534	3.38e-162	478.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1WW2Y@135613|Chromatiales	135613|Chromatiales	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_368010_1	765911.Thivi_0579	4.32e-20	96.3	COG4547@1|root,COG4547@2|Bacteria,1R0ZM@1224|Proteobacteria,1RQT2@1236|Gammaproteobacteria,1WX1X@135613|Chromatiales	135613|Chromatiales	H	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	CobT,CobT_C,VWA,VWA_2
k59_304260_1	395495.Lcho_0122	1.41e-73	232.0	COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,2VH4M@28216|Betaproteobacteria,1KJNU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	purT	-	2.1.2.2	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp,Epimerase
k59_1007236_1	247634.GPB2148_3881	1.66e-110	340.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1J4U2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_832853_1	367299.JOEE01000002_gene2636	9.55e-139	405.0	COG0593@1|root,COG0593@2|Bacteria,2GJKI@201174|Actinobacteria,4FFMY@85021|Intrasporangiaceae	201174|Actinobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C
k59_480426_1	1121013.P873_04840	1.63e-44	165.0	COG1807@1|root,COG1807@2|Bacteria,1MXH5@1224|Proteobacteria,1RSQE@1236|Gammaproteobacteria,1X589@135614|Xanthomonadales	135614|Xanthomonadales	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_22,PMT_2
k59_18590_1	290340.AAur_3612	1.94e-113	345.0	COG3501@1|root,COG3501@2|Bacteria,2HGNZ@201174|Actinobacteria,1WAA4@1268|Micrococcaceae	201174|Actinobacteria	S	Rhs element vgr protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_base_V
k59_187398_1	765911.Thivi_0755	1.4e-31	126.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1RMA2@1236|Gammaproteobacteria,1WXJP@135613|Chromatiales	135613|Chromatiales	M	PFAM glycosyl transferase family 39	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_1771301_1	1385519.N801_03070	1.36e-77	245.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria,4FFQZ@85021|Intrasporangiaceae	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
k59_128709_1	1249627.D779_2947	3.65e-55	189.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria,1WWCP@135613|Chromatiales	135613|Chromatiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_128709_2	768671.ThimaDRAFT_4706	3.58e-17	80.5	COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,1RQ6N@1236|Gammaproteobacteria,1WX18@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_368032_1	1095767.CAHD01000213_gene638	1.15e-108	319.0	COG0682@1|root,COG0682@2|Bacteria,2GKSS@201174|Actinobacteria,4F25U@85016|Cellulomonadaceae	201174|Actinobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	LGT
k59_896303_1	926564.KI911642_gene2398	4.17e-62	209.0	COG2211@1|root,COG2211@2|Bacteria,2HU9J@201174|Actinobacteria,4F5R3@85017|Promicromonosporaceae	201174|Actinobacteria	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
k59_252265_1	408672.NBCG_05150	1.33e-08	55.5	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4DP4J@85009|Propionibacteriales	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_18615_1	1278307.KB906994_gene2863	1.01e-27	113.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,2QJ5B@267894|Psychromonadaceae	1236|Gammaproteobacteria	L	COG3547 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_368034_1	367299.JOEE01000012_gene3273	6.34e-103	303.0	COG3396@1|root,COG3396@2|Bacteria,2GKXZ@201174|Actinobacteria,4FFQB@85021|Intrasporangiaceae	201174|Actinobacteria	S	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like	-	-	-	-	-	-	-	-	-	-	-	-	MiaE_2
k59_187410_1	404380.Gbem_0644	2.99e-12	65.9	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,43TQ2@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_187410_2	335543.Sfum_3388	3.18e-21	90.5	COG2259@1|root,COG2259@2|Bacteria,1NC5I@1224|Proteobacteria,42V27@68525|delta/epsilon subdivisions,2WS2G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Methylamine	-	-	-	-	-	-	-	-	-	-	-	-	MauE
k59_1481484_1	314345.SPV1_00642	1.69e-28	118.0	COG3746@1|root,COG3746@2|Bacteria,1MY3M@1224|Proteobacteria	1224|Proteobacteria	P	phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_368042_1	1283300.ATXB01000001_gene965	9.58e-40	143.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,1XEE0@135618|Methylococcales	135618|Methylococcales	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_1712856_1	391615.ABSJ01000051_gene1106	7.62e-47	167.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1J4QH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Permease	perM	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K03548	-	-	-	-	ko00000,ko02000	2.A.86.1	-	-	AI-2E_transport
k59_657037_1	32057.KB217478_gene1921	9.37e-22	95.1	COG1975@1|root,COG1975@2|Bacteria,1G2SP@1117|Cyanobacteria,1HKKM@1161|Nostocales	1117|Cyanobacteria	O	XdhC Rossmann domain	-	-	-	-	-	-	-	-	-	-	-	-	XdhC_C,XdhC_CoxI
k59_657039_1	1049564.TevJSym_ac00730	1.45e-107	322.0	COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,1RM9W@1236|Gammaproteobacteria,1J55H@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	COG1157 Flagellar biosynthesis type III secretory pathway ATPase	fliI	GO:0003674,GO:0005488,GO:0005515,GO:0042802	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1481498_2	765912.Thimo_1179	1.17e-71	218.0	COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,1S3XF@1236|Gammaproteobacteria,1WY24@135613|Chromatiales	135613|Chromatiales	O	redox protein, regulator of disulfide bond formation	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
k59_1835664_1	713587.THITH_07385	2.35e-137	411.0	COG0457@1|root,COG0457@2|Bacteria,1QXGV@1224|Proteobacteria	1224|Proteobacteria	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
k59_1835664_2	243090.RB11084	5.06e-24	105.0	COG0457@1|root,COG0795@1|root,COG0457@2|Bacteria,COG0795@2|Bacteria,2IXP3@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,TPR_16
k59_1246451_2	697282.Mettu_0336	8.08e-51	178.0	COG1368@1|root,COG1368@2|Bacteria,1RG6W@1224|Proteobacteria,1RY34@1236|Gammaproteobacteria,1XFZX@135618|Methylococcales	135618|Methylococcales	M	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_421679_1	1488328.JMCL01000014_gene362	3.75e-30	115.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_1420498_1	287.DR97_217	4.75e-18	88.6	COG0515@1|root,COG0515@2|Bacteria,1MWVZ@1224|Proteobacteria,1RQBQ@1236|Gammaproteobacteria,1YFGC@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	KLT	serine threonine protein kinase	stk1	-	2.7.11.1	ko:K08282,ko:K11916,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001,ko02044	-	-	-	FGE-sulfatase,Pkinase
k59_1246458_1	1394178.AWOO02000040_gene8544	1.99e-58	197.0	COG1609@1|root,COG1609@2|Bacteria,2GK1X@201174|Actinobacteria,4EHAQ@85012|Streptosporangiales	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
k59_832898_1	572477.Alvin_2880	3.8e-69	222.0	COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,1S0Z6@1236|Gammaproteobacteria,1WXDJ@135613|Chromatiales	135613|Chromatiales	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1070938_1	244581.IM40_01945	7.77e-14	79.3	COG2982@1|root,COG2982@2|Bacteria,1MUNH@1224|Proteobacteria,2TT0W@28211|Alphaproteobacteria,47FAC@766|Rickettsiales	766|Rickettsiales	M	AsmA family	asmA	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
k59_603584_1	190650.CC_1796	1.32e-107	327.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,2KHEW@204458|Caulobacterales	204458|Caulobacterales	L	Transposase DDE domain	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1_6,DUF772
k59_1661503_1	768671.ThimaDRAFT_2445	1.66e-89	295.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales	135613|Chromatiales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1316043_1	768671.ThimaDRAFT_2746	4.66e-91	286.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1WX77@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
k59_1718910_1	1521187.JPIM01000127_gene250	1.89e-10	59.7	COG3293@1|root,COG3293@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_1718910_2	106370.Francci3_3385	1.31e-35	131.0	COG3293@1|root,COG3293@2|Bacteria,2GMT0@201174|Actinobacteria,4EV5F@85013|Frankiales	201174|Actinobacteria	L	PFAM transposase IS4 family protein	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_1489249_1	1713.JOFV01000023_gene1330	2.21e-90	278.0	COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria,4F0PF@85016|Cellulomonadaceae	201174|Actinobacteria	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_1489249_2	1454010.JEOE01000015_gene1104	1.2e-15	79.3	COG0488@1|root,COG0488@2|Bacteria,2GJ5M@201174|Actinobacteria,4F1TZ@85016|Cellulomonadaceae	201174|Actinobacteria	S	ATPases associated with a variety of cellular activities	yjjK	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_904869_1	1429916.X566_03845	2.29e-33	130.0	28H8H@1|root,2Z7KE@2|Bacteria,1MV77@1224|Proteobacteria,2TSVV@28211|Alphaproteobacteria,3JRNZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Aerotolerance regulator N-terminal	MA20_44655	-	-	-	-	-	-	-	-	-	-	-	BatA,DUF4159
k59_1367057_1	59538.XP_005974531.1	2.4e-78	261.0	COG0293@1|root,COG0294@1|root,COG0465@1|root,COG1109@1|root,KOG0731@2759|Eukaryota,KOG1220@2759|Eukaryota,KOG2544@2759|Eukaryota,KOG4589@2759|Eukaryota,38FRA@33154|Opisthokonta,3BEA7@33208|Metazoa,3CR69@33213|Bilateria,48125@7711|Chordata,492S9@7742|Vertebrata,3JC82@40674|Mammalia,4J3RZ@91561|Cetartiodactyla	33208|Metazoa	O	AFG3-like protein	-	-	-	ko:K08956	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
k59_1718912_1	1121946.AUAX01000009_gene4398	2.39e-09	63.5	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2IF27@201174|Actinobacteria,4DA39@85008|Micromonosporales	201174|Actinobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_12,Trans_reg_C
k59_1080370_1	1173020.Cha6605_5180	3e-41	150.0	COG5433@1|root,COG5433@2|Bacteria,1G2IT@1117|Cyanobacteria	1117|Cyanobacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_26915_1	498211.CJA_2421	2.81e-58	194.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria,1FG97@10|Cellvibrio	1236|Gammaproteobacteria	C	FAD dependent oxidoreductase	eryB	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO
k59_963890_1	1439940.BAY1663_00718	1.32e-21	104.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,Protoglobin
k59_1316066_1	396588.Tgr7_1535	1.03e-121	372.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1WXK8@135613|Chromatiales	135613|Chromatiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_193530_1	235985.BBPN01000002_gene5020	2.55e-44	165.0	COG1251@1|root,COG1251@2|Bacteria,2GJ3U@201174|Actinobacteria,2NF73@228398|Streptacidiphilus	201174|Actinobacteria	C	BFD-like [2Fe-2S] binding domain	nirB	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
k59_260864_1	395019.Bmul_5123	3.45e-81	269.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,1K22A@119060|Burkholderiaceae	28216|Betaproteobacteria	EQ	5-oxoprolinase	oplaH	-	3.5.2.14,3.5.2.9	ko:K01469,ko:K01473	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00251,R03187	RC00553,RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_1601246_1	1122609.AUGT01000005_gene1697	1.7e-59	204.0	COG0699@1|root,COG0699@2|Bacteria,2GM68@201174|Actinobacteria,4DPRU@85009|Propionibacteriales	201174|Actinobacteria	S	50S ribosome-binding GTPase	PPA1638	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
k59_603620_1	983920.Y88_2995	3.28e-92	289.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,2K0VT@204457|Sphingomonadales	204457|Sphingomonadales	V	ABC-type multidrug transport system, ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_904890_2	1163617.SCD_n02930	1.02e-208	582.0	COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,2VRJN@28216|Betaproteobacteria	28216|Betaproteobacteria	S	associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
k59_904890_3	580332.Slit_2280	2.91e-32	122.0	COG0240@1|root,COG0240@2|Bacteria,1RED0@1224|Proteobacteria,2W2AD@28216|Betaproteobacteria	28216|Betaproteobacteria	I	PFAM NAD-dependent glycerol-3-phosphate dehydrogenase	-	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_1426647_1	519989.ECTPHS_11717	1.69e-106	320.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1WVUW@135613|Chromatiales	135613|Chromatiales	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_1367072_2	1124983.PFLCHA0_c40600	8.78e-32	128.0	COG2207@1|root,COG2207@2|Bacteria,1R7G3@1224|Proteobacteria,1RXMK@1236|Gammaproteobacteria,1YPCC@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_1718935_2	258533.BN977_05851	9.96e-22	94.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,234F0@1762|Mycobacteriaceae	201174|Actinobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_83085_1	1230476.C207_00014	3.94e-78	245.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria,3JWD8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_83085_2	1219045.BV98_002753	1.78e-39	138.0	COG3415@1|root,COG3415@2|Bacteria,1QVAE@1224|Proteobacteria	1224|Proteobacteria	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
k59_545111_1	225937.HP15_3605	3.07e-55	191.0	COG2133@1|root,COG2133@2|Bacteria,1R65J@1224|Proteobacteria,1RYQV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Large extracellular alpha-helical protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1718940_1	396588.Tgr7_1396	3e-106	323.0	COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,1RNUM@1236|Gammaproteobacteria,1WW3E@135613|Chromatiales	135613|Chromatiales	S	Deoxyribodipyrimidine photo-lyase-related protein	-	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP
k59_260890_1	1089551.KE386572_gene896	2.76e-96	286.0	COG1028@1|root,COG1028@2|Bacteria,1MW46@1224|Proteobacteria,2TUTU@28211|Alphaproteobacteria,4BRFN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	IQ	KR domain	MA20_08760	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_83093_1	555779.Dthio_PD1141	1.83e-43	147.0	COG2087@1|root,COG2087@2|Bacteria,1RH0A@1224|Proteobacteria,42TMF@68525|delta/epsilon subdivisions,2WQNM@28221|Deltaproteobacteria,2MBTN@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate	cobU	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
k59_1601261_1	768671.ThimaDRAFT_1939	4.16e-84	260.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,1T5B6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_963936_1	926564.KI911593_gene100	2.11e-86	267.0	COG3393@1|root,COG3393@2|Bacteria,2GMD2@201174|Actinobacteria,4F3PZ@85017|Promicromonosporaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4081)	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,DUF4081,FR47
k59_1543012_1	1304885.AUEY01000080_gene1033	4.27e-126	370.0	COG2801@1|root,COG2801@2|Bacteria,1PFYJ@1224|Proteobacteria,439VW@68525|delta/epsilon subdivisions,2X5A0@28221|Deltaproteobacteria,2MP3D@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_134918_1	1453501.JELR01000001_gene2287	6.13e-39	148.0	COG0427@1|root,COG0427@2|Bacteria,1PJY0@1224|Proteobacteria,1RPS6@1236|Gammaproteobacteria,46523@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	COG0427 Acetyl-CoA hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C
k59_376696_1	1304865.JAGF01000001_gene2477	2.15e-83	276.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,COG1145@2|Bacteria,2I995@201174|Actinobacteria	201174|Actinobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_83106_1	765914.ThisiDRAFT_1142	1.21e-205	581.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1WWC9@135613|Chromatiales	135613|Chromatiales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_1661565_1	1353531.AZNX01000012_gene3824	3.43e-39	145.0	COG1024@1|root,COG1024@2|Bacteria,1MU0B@1224|Proteobacteria,2TQW3@28211|Alphaproteobacteria,4B7Z4@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	enoyl-CoA hydratase	-	-	1.1.1.31,4.2.1.17	ko:K00020,ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05066,R05595,R06411,R06412,R06942,R08093	RC00099,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_2
k59_1080429_1	589865.DaAHT2_1556	1.44e-34	123.0	COG0848@1|root,COG0848@2|Bacteria,1Q3ZH@1224|Proteobacteria,431X3@68525|delta/epsilon subdivisions,2WWDP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_1080429_2	555779.Dthio_PD2849	2.44e-49	164.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria	1224|Proteobacteria	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_1316118_1	340177.Cag_1058	7.37e-68	217.0	COG2038@1|root,COG2038@2|Bacteria,1FD5I@1090|Chlorobi	1090|Chlorobi	F	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	-	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
k59_1543014_1	1288298.rosmuc_00656	1.91e-13	72.0	COG4630@1|root,COG4630@2|Bacteria,1MWI1@1224|Proteobacteria,2TR3Q@28211|Alphaproteobacteria,46NSF@74030|Roseovarius	28211|Alphaproteobacteria	C	COG4630 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A	xdhA	-	1.17.1.4	ko:K13481	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
k59_1543014_2	680198.SCAB_8581	6.83e-16	85.1	COG1975@1|root,COG1975@2|Bacteria,2GIZS@201174|Actinobacteria	201174|Actinobacteria	O	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
k59_838971_1	935863.AWZR01000012_gene2529	4.49e-12	65.9	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1X3UC@135614|Xanthomonadales	135614|Xanthomonadales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_838971_2	1504672.669783389	3.28e-31	123.0	COG0128@1|root,COG0283@1|root,COG0128@2|Bacteria,COG0283@2|Bacteria,1MWMK@1224|Proteobacteria,2VGZF@28216|Betaproteobacteria,4AC71@80864|Comamonadaceae	28216|Betaproteobacteria	F	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin,EPSP_synthase
k59_663206_1	1123024.AUII01000006_gene4608	2.09e-32	117.0	COG3247@1|root,COG3247@2|Bacteria	2|Bacteria	U	response to pH	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
k59_663206_2	1206731.BAGB01000054_gene3812	9.67e-40	140.0	COG0208@1|root,COG0208@2|Bacteria,2GK46@201174|Actinobacteria,4FUFS@85025|Nocardiaceae	201174|Actinobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0090304,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
k59_83114_1	419947.MRA_2115	1.32e-76	253.0	COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria,235KG@1762|Mycobacteriaceae	201174|Actinobacteria	KL	SNF2 family N-terminal domain	helZ	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
k59_83114_2	1123024.AUII01000019_gene3981	7.31e-36	129.0	COG4279@1|root,COG4279@2|Bacteria,2GIYW@201174|Actinobacteria,4E233@85010|Pseudonocardiales	201174|Actinobacteria	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
k59_260926_1	590998.Celf_0222	9.83e-112	329.0	COG1266@1|root,COG1266@2|Bacteria,2GK11@201174|Actinobacteria,4F0GX@85016|Cellulomonadaceae	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_1130109_1	269797.Mbar_A2654	1.06e-17	88.2	COG0577@1|root,arCOG02315@2157|Archaea,2XYJU@28890|Euryarchaeota,2N9SS@224756|Methanomicrobia	224756|Methanomicrobia	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_486518_1	1123256.KB907935_gene2465	1.9e-13	70.1	COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,1X30R@135614|Xanthomonadales	135614|Xanthomonadales	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
k59_486518_2	1249627.D779_2233	7.75e-54	178.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,1WW0G@135613|Chromatiales	135613|Chromatiales	J	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
k59_83115_1	1537994.JQFW01000007_gene2945	4.27e-71	226.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,464Z9@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Glycerol-3-phosphate dehydrogenase	gpsA	GO:0003674,GO:0003824,GO:0004367,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006072,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	iJN746.PP_4169,iSFV_1184.SFV_3923	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_376713_1	1713.JOFV01000005_gene2259	3.94e-85	261.0	COG0385@1|root,COG0385@2|Bacteria,2GJQU@201174|Actinobacteria,4F0Q8@85016|Cellulomonadaceae	201174|Actinobacteria	S	SBF-like CPA transporter family (DUF4137)	-	-	-	ko:K14347	-	-	-	-	ko00000,ko02000,ko04147	2.A.93.1	-	-	SBF_like
k59_1844321_1	105422.BBPM01000026_gene4088	1.58e-09	59.3	COG1716@1|root,COG1716@2|Bacteria,2HPF7@201174|Actinobacteria,2NH62@228398|Streptacidiphilus	201174|Actinobacteria	T	Domain of unknown function (DUF1707)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1707,FHA
k59_1844321_2	1397528.Q671_17690	1.73e-05	47.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XHBW@135619|Oceanospirillales	135619|Oceanospirillales	P	P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_1191701_1	1267005.KB911257_gene683	1.3e-101	323.0	COG0433@1|root,COG1484@1|root,COG0433@2|Bacteria,COG1484@2|Bacteria,1P0I3@1224|Proteobacteria,2U0J8@28211|Alphaproteobacteria,3N9D3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DUF853,DUF87
k59_1601289_2	525368.HMPREF0591_3974	1.27e-14	73.2	COG2009@1|root,COG2009@2|Bacteria,2IKU7@201174|Actinobacteria,23A0P@1762|Mycobacteriaceae	201174|Actinobacteria	C	succinate dehydrogenase	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_310485_1	1038859.AXAU01000037_gene5367	6.12e-57	197.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TQSC@28211|Alphaproteobacteria,3JSH5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	UvrD-like helicase C-terminal domain	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_904966_1	472759.Nhal_2468	1.16e-117	351.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1WVYA@135613|Chromatiales	135613|Chromatiales	H	TIGRFAM molybdenum cofactor synthesis	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_1012337_1	396588.Tgr7_3085	2.3e-49	169.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RR0P@1236|Gammaproteobacteria,1X0E3@135613|Chromatiales	135613|Chromatiales	E	PFAM glutamine synthetase catalytic region	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_1012337_2	555778.Hneap_0795	5.58e-64	199.0	COG0864@1|root,COG0864@2|Bacteria,1RDN6@1224|Proteobacteria,1S85W@1236|Gammaproteobacteria,1X274@135613|Chromatiales	135613|Chromatiales	K	NikR C terminal nickel binding domain	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
k59_1012337_3	314345.SPV1_06124	9.23e-39	136.0	COG3665@1|root,COG3665@2|Bacteria,1N2KR@1224|Proteobacteria	1224|Proteobacteria	P	Urea carboxylase-associated protein 2	IV02_09290	-	-	ko:K09967	-	-	-	-	ko00000	-	-	-	DUF1989
k59_427771_1	765912.Thimo_0577	4.45e-62	199.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1WW37@135613|Chromatiales	135613|Chromatiales	O	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
k59_1844338_1	1304865.JAGF01000001_gene3093	5.96e-111	337.0	COG0296@1|root,COG0296@2|Bacteria,2GMIS@201174|Actinobacteria,4F2CG@85016|Cellulomonadaceae	201174|Actinobacteria	G	SMART alpha amylase catalytic sub domain	treZ	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0033942,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0071704,GO:1901575,GO:1901576	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
k59_1543037_1	546274.EIKCOROL_01803	4.06e-72	223.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2VQ19@28216|Betaproteobacteria,2KQWG@206351|Neisseriales	206351|Neisseriales	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
k59_1543037_2	2340.JV46_19310	4.04e-21	84.7	COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,1J708@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
k59_1543037_3	998674.ATTE01000001_gene2805	9.59e-58	181.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,460T7@72273|Thiotrichales	72273|Thiotrichales	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
k59_1489352_1	1283300.ATXB01000002_gene3190	2.31e-18	86.3	COG3079@1|root,COG3079@2|Bacteria,1N7W0@1224|Proteobacteria,1SCPW@1236|Gammaproteobacteria,1XFDI@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0149 family	-	-	-	ko:K09895	-	-	-	-	ko00000	-	-	-	UPF0149
k59_1489352_2	395493.BegalDRAFT_1731	3.59e-19	86.7	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,45ZRX@72273|Thiotrichales	72273|Thiotrichales	E	Belongs to the peptidase M24B family	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_376739_1	765910.MARPU_04170	2.25e-81	258.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales	135613|Chromatiales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_1130126_1	33898.JRHJ01000001_gene722	7.41e-102	304.0	28JC4@1|root,2Z96S@2|Bacteria,2IEPB@201174|Actinobacteria	201174|Actinobacteria	S	P22 coat protein-protein 5 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	P22_CoatProtein
k59_1130126_2	68199.JNZO01000025_gene5827	9.68e-19	82.8	2B2KJ@1|root,31V5Z@2|Bacteria,2GV1Q@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_486545_1	1439940.BAY1663_01811	2.03e-60	213.0	COG0004@1|root,COG5001@1|root,COG0004@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	2.1.1.80,3.1.1.61	ko:K03320,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02000,ko02022,ko02035	1.A.11	-	-	Ammonium_transp,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9
k59_1013074_1	1236902.ANAS01000022_gene41	5.2e-10	65.1	COG2234@1|root,COG2234@2|Bacteria,2IDP0@201174|Actinobacteria,4EFH8@85012|Streptosporangiales	201174|Actinobacteria	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_84306_1	1193181.BN10_520027	1.09e-41	154.0	COG5401@1|root,COG5401@2|Bacteria,2GJ5Y@201174|Actinobacteria,4FFE2@85021|Intrasporangiaceae	201174|Actinobacteria	S	Sporulation and spore germination	lpqB	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Germane,Gmad1
k59_1778395_1	631362.Thi970DRAFT_04432	1.3e-107	325.0	COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,1T2D1@1236|Gammaproteobacteria,1X28U@135613|Chromatiales	135613|Chromatiales	P	Sodium/hydrogen exchanger family	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger
k59_1367962_1	1198232.CYCME_1113	9.86e-87	279.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria,463WK@72273|Thiotrichales	72273|Thiotrichales	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,PP-binding
k59_1317305_1	243159.AFE_1843	3.35e-101	313.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1SJQ1@1236|Gammaproteobacteria,2NDRU@225057|Acidithiobacillales	225057|Acidithiobacillales	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_1602091_1	187272.Mlg_2353	6.81e-06	52.8	COG0463@1|root,COG0463@2|Bacteria,1RA3F@1224|Proteobacteria,1T24F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.305	ko:K16698,ko:K21363	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT2	-	Glycos_transf_2
k59_377879_1	1112217.PPL19_18005	6.57e-103	332.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_28488_1	710687.KI912270_gene565	2.97e-138	407.0	COG4584@1|root,COG4584@2|Bacteria,2GM4J@201174|Actinobacteria,2377M@1762|Mycobacteriaceae	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_778139_1	522373.Smlt1277	2.33e-68	231.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1X45Q@135614|Xanthomonadales	135614|Xanthomonadales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_782647_2	1049564.TevJSym_am00800	4.33e-29	114.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,1S2U7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_973416_2	367299.JOEE01000003_gene2683	4.35e-73	225.0	COG1024@1|root,COG1024@2|Bacteria,2GJG7@201174|Actinobacteria,4FG4Q@85021|Intrasporangiaceae	201174|Actinobacteria	I	enoyl-CoA hydratase	echA6	GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0030312,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_1088095_1	313589.JNB_12913	9.56e-35	125.0	COG1694@1|root,COG1694@2|Bacteria,2IKRC@201174|Actinobacteria,4FHQX@85021|Intrasporangiaceae	201174|Actinobacteria	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG,MazG-like
k59_92617_1	1123020.AUIE01000006_gene4013	9.94e-97	312.0	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,1S08E@1236|Gammaproteobacteria,1YENW@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Glycosyl transferase family 21	bcsA	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_17,Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,PilZ
k59_914415_1	717785.HYPMC_2585	1.89e-89	265.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2U592@28211|Alphaproteobacteria,3N6WR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_845067_1	1123354.AUDR01000016_gene1414	1.54e-30	124.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2VHBY@28216|Betaproteobacteria,1KSJ0@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Asparagine synthase	-	-	-	-	-	-	-	-	-	-	-	-	Asn_synthase,GATase_7
k59_1548825_1	1187851.A33M_1976	3.8e-68	213.0	COG1670@1|root,COG1670@2|Bacteria,1MVG4@1224|Proteobacteria,2TUIK@28211|Alphaproteobacteria,3FD4Z@34008|Rhodovulum	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	rimJ	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
k59_845070_1	1266925.JHVX01000002_gene1028	3.63e-55	189.0	COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,2VPE5@28216|Betaproteobacteria,372J2@32003|Nitrosomonadales	28216|Betaproteobacteria	Q	Saccharopine dehydrogenase C-terminal domain	hss	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_727599_1	886293.Sinac_5243	3.6e-127	370.0	COG0115@1|root,COG0115@2|Bacteria,2J2GT@203682|Planctomycetes	203682|Planctomycetes	H	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_386104_1	932678.THERU_01860	2.45e-78	248.0	COG1423@1|root,COG1423@2|Bacteria	2|Bacteria	L	RNA ligase	-	-	6.5.1.1	ko:K07468	-	-	R00381	RC00005	ko00000,ko01000	-	-	-	RNA_ligase
k59_1262254_3	450851.PHZ_c3199	7.19e-23	97.1	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2TU3I@28211|Alphaproteobacteria,2KHJJ@204458|Caulobacterales	204458|Caulobacterales	C	Cytochrome bd terminal oxidase subunit II	-	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
k59_1017566_1	399795.CtesDRAFT_PD4106	6.64e-49	167.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,2VM6E@28216|Betaproteobacteria,4AA5G@80864|Comamonadaceae	28216|Betaproteobacteria	M	lytic transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	SLT,Sel1
k59_1017566_2	1249627.D779_1866	2.62e-46	158.0	COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1RNDT@1236|Gammaproteobacteria,1WW02@135613|Chromatiales	135613|Chromatiales	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10,RmlD_sub_bind
k59_1135964_1	768671.ThimaDRAFT_0093	3.02e-98	303.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1WWEZ@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_845073_2	1035308.AQYY01000001_gene2348	1.59e-104	306.0	COG3707@1|root,COG3707@2|Bacteria,1U6TA@1239|Firmicutes,24G9P@186801|Clostridia,261NT@186807|Peptococcaceae	186801|Clostridia	T	response regulator receiver	-	-	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
k59_433843_1	1182590.BN5_00522	6.82e-19	85.5	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria,1YF30@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008033,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016070,GO:0016740,GO:0016765,GO:0019222,GO:0031323,GO:0031326,GO:0032268,GO:0033554,GO:0034248,GO:0034470,GO:0034605,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043555,GO:0044237,GO:0044238,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0051716,GO:0052381,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990497,GO:2000112,GO:2000765	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
k59_433843_2	349106.PsycPRwf_0821	6.84e-35	124.0	COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,1S8W0@1236|Gammaproteobacteria,3NK0S@468|Moraxellaceae	1236|Gammaproteobacteria	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	GO:0003674,GO:0003676,GO:0003677,GO:0003681,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016246,GO:0016441,GO:0016458,GO:0017148,GO:0019222,GO:0022607,GO:0022613,GO:0022618,GO:0030423,GO:0031047,GO:0031123,GO:0031124,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032268,GO:0032269,GO:0032270,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0035194,GO:0040029,GO:0040033,GO:0043170,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045974,GO:0045975,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:2000112,GO:2000113	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
k59_1432942_1	1035308.AQYY01000001_gene3475	1.96e-90	277.0	COG0477@1|root,COG2814@2|Bacteria,1V36U@1239|Firmicutes,2585F@186801|Clostridia,264YU@186807|Peptococcaceae	186801|Clostridia	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_386117_1	292415.Tbd_0489	1.39e-102	303.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2VKZV@28216|Betaproteobacteria,1KRBM@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Inhibitor of apoptosis-promoting Bax1	-	-	-	ko:K19416	-	M00742	-	-	ko00000,ko00002,ko02000	1.A.14.2.1	-	-	Bax1-I
k59_199446_1	446466.Cfla_2258	2.66e-141	424.0	COG0464@1|root,COG0464@2|Bacteria,2I8CR@201174|Actinobacteria	201174|Actinobacteria	O	PFAM AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_92663_1	105422.BBPM01000020_gene2779	4.62e-15	72.8	COG1569@1|root,COG1569@2|Bacteria,2IMP1@201174|Actinobacteria	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
k59_669117_1	742767.HMPREF9456_00239	1.38e-25	104.0	COG0350@1|root,COG2207@1|root,COG0350@2|Bacteria,COG2207@2|Bacteria,4NFYC@976|Bacteroidetes,2FP18@200643|Bacteroidia,22YIW@171551|Porphyromonadaceae	976|Bacteroidetes	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	ada	-	2.1.1.63	ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	DNA_binding_1,HTH_18,Methyltransf_1N
k59_387620_2	1366050.N234_14725	1.43e-51	174.0	COG0492@1|root,COG0492@2|Bacteria,1MW14@1224|Proteobacteria,2VGZS@28216|Betaproteobacteria,1K1VD@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Ferredoxin--NADP reductase	trxB2	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
k59_610691_1	1172188.KB911827_gene4320	5.41e-65	211.0	COG0769@1|root,COG0769@2|Bacteria,2I2TV@201174|Actinobacteria,4FK2H@85021|Intrasporangiaceae	201174|Actinobacteria	M	Mur ligase middle domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1727,Mur_ligase_M
k59_1089099_1	471853.Bcav_0638	5.16e-88	275.0	COG2890@1|root,COG2890@2|Bacteria,2GJPP@201174|Actinobacteria	201174|Actinobacteria	J	methyltransferase	rsmC	-	-	-	-	-	-	-	-	-	-	-	MTS
k59_1607703_1	765913.ThidrDRAFT_4183	1.92e-48	170.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1WW7K@135613|Chromatiales	135613|Chromatiales	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_434643_1	1193181.BN10_610016	1.32e-68	220.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4FFHF@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	aldC	-	1.2.1.3,1.2.1.39,1.2.1.8	ko:K00128,ko:K00130,ko:K00146	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00360,map00380,map00410,map00561,map00620,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00555	R00264,R00631,R00710,R00904,R01752,R01986,R02536,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_434643_2	1193181.BN10_610015	2.75e-21	92.0	COG0174@1|root,COG0174@2|Bacteria,2GM3K@201174|Actinobacteria,4FETN@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the glutamine synthetase family	glnA4	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_728409_1	1249627.D779_3617	7.77e-82	263.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,1X257@135613|Chromatiales	135613|Chromatiales	P	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
k59_1497659_1	1110502.TMO_1197	4.11e-62	211.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TR00@28211|Alphaproteobacteria,2JQVT@204441|Rhodospirillales	204441|Rhodospirillales	J	Amidase	-	-	3.5.1.54	ko:K01457	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120	-	R00005	RC02756	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_1136691_1	471853.Bcav_4217	5.27e-105	320.0	COG1475@1|root,COG5373@1|root,COG1475@2|Bacteria,COG5373@2|Bacteria,2GNRN@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the ParB family	parB	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_1198722_1	1298867.AUES01000037_gene748	4.16e-09	62.8	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria,2TY6Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	QU	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1607711_1	675812.VHA_001654	3.53e-87	272.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1XUVI@135623|Vibrionales	135623|Vibrionales	Q	COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_387652_2	883067.HMPREF9237_01153	5.71e-52	171.0	COG1187@1|root,COG1187@2|Bacteria,2GJ4N@201174|Actinobacteria,4D4C0@85005|Actinomycetales	201174|Actinobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_1784009_1	1249627.D779_0261	2.04e-77	231.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,1TJD2@1236|Gammaproteobacteria,1WYEP@135613|Chromatiales	135613|Chromatiales	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
k59_669918_1	367299.JOEE01000002_gene2339	2.67e-54	184.0	COG0246@1|root,COG0246@2|Bacteria,2GJ4F@201174|Actinobacteria,4FF9K@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the mannitol dehydrogenase family	mtlK	-	1.1.1.67	ko:K00045	ko00051,map00051	-	R00868	RC00085	ko00000,ko00001,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
k59_915963_1	523791.Kkor_0153	6.23e-49	160.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1RMIZ@1236|Gammaproteobacteria,1XH7Z@135619|Oceanospirillales	135619|Oceanospirillales	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	Crp,HTH_Crp_2,cNMP_binding
k59_915963_2	454957.IA64_20410	5.5e-88	267.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1X42P@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
k59_200243_1	367299.JOEE01000004_gene1156	3.16e-91	278.0	COG0451@1|root,COG0451@2|Bacteria,2GP01@201174|Actinobacteria,4FEU9@85021|Intrasporangiaceae	201174|Actinobacteria	GM	epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_1018288_1	1386089.N865_01380	9.07e-98	300.0	COG3344@1|root,COG3344@2|Bacteria,2GUJS@201174|Actinobacteria	201174|Actinobacteria	L	RNA-directed DNA polymerase (reverse transcriptase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_845905_1	28042.GU90_06225	1.68e-63	210.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,2GM21@201174|Actinobacteria,4DZAD@85010|Pseudonocardiales	201174|Actinobacteria	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	fmu	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
k59_387675_1	96561.Dole_2313	3.67e-96	295.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2MI74@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	Sigma-54 interaction domain	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	HTH_8,PAS_4,PAS_9,Sigma54_activat
k59_845906_1	1049564.TevJSym_aq00560	1.11e-160	471.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1J4RW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA helicase	uvrD	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0042802,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1855558_1	1121396.KB893101_gene476	1.5e-90	274.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42MH7@68525|delta/epsilon subdivisions,2WK12@28221|Deltaproteobacteria,2MIA2@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Electron transfer flavoprotein alpha	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
k59_1373683_1	338966.Ppro_3716	3.05e-123	358.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42R4P@68525|delta/epsilon subdivisions,2X5AT@28221|Deltaproteobacteria,43W1U@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_1373683_2	246197.MXAN_3613	1.87e-52	189.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42QTE@68525|delta/epsilon subdivisions,2WN61@28221|Deltaproteobacteria,2YUPI@29|Myxococcales	28221|Deltaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,rve
k59_1018302_1	983545.Glaag_4028	7.77e-52	168.0	COG2930@1|root,COG2930@2|Bacteria,1RCH3@1224|Proteobacteria,1S2SV@1236|Gammaproteobacteria,466VF@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Las17-binding protein actin regulator	VPA0371	-	-	-	-	-	-	-	-	-	-	-	Ysc84
k59_1784036_1	58123.JOFJ01000001_gene3300	1.66e-14	72.4	COG1251@1|root,COG1251@2|Bacteria,2I3CF@201174|Actinobacteria,4EQYP@85012|Streptosporangiales	201174|Actinobacteria	C	Reductase C-terminal	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
k59_1784036_2	388739.RSK20926_07938	3.05e-16	75.1	COG3794@1|root,COG3794@2|Bacteria,1RI9G@1224|Proteobacteria,2U7KA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
k59_1433802_2	1265505.ATUG01000002_gene2506	5.02e-94	284.0	COG5598@1|root,COG5598@2|Bacteria,1N18H@1224|Proteobacteria,43BDY@68525|delta/epsilon subdivisions,2X6SF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
k59_1549622_1	1122933.JNIY01000004_gene2094	6.4e-17	81.3	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_6,Hydrolase_4
k59_1726139_1	675812.VHA_000174	5.7e-75	244.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,1XU5H@135623|Vibrionales	135623|Vibrionales	L	DNA helicase	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
k59_94221_2	656024.FsymDg_0923	1.22e-76	237.0	arCOG08992@1|root,32VE4@2|Bacteria,2IJTQ@201174|Actinobacteria,4ESZW@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Abi_2
k59_94221_3	1304865.JAGF01000001_gene716	2.7e-99	298.0	COG3285@1|root,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4F26I@85016|Cellulomonadaceae	201174|Actinobacteria	L	TIGRFAM DNA polymerase LigD, polymerase domain protein	ligD	-	-	-	-	-	-	-	-	-	-	-	DNA_primase_S
k59_916014_1	397290.C810_03115	4.09e-05	45.1	COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,247N4@186801|Clostridia,27JEC@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Elongation factor G, domain IV	fusA2	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_916014_2	935839.JAGJ01000003_gene1536	7.07e-05	45.1	COG2220@1|root,COG2220@2|Bacteria,2GNHK@201174|Actinobacteria,4F4J7@85017|Promicromonosporaceae	201174|Actinobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
k59_916014_3	1323361.JPOC01000008_gene3450	3.94e-169	480.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4FX1U@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_845922_1	43759.JNWK01000029_gene5406	2.57e-164	475.0	COG0454@1|root,COG0464@1|root,COG0456@2|Bacteria,COG0464@2|Bacteria,2GJ07@201174|Actinobacteria	201174|Actinobacteria	KO	Belongs to the AAA ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	AAA,Acetyltransf_1
k59_1855587_1	498211.CJA_1427	1.88e-80	248.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR3Q@1236|Gammaproteobacteria,1FIIT@10|Cellvibrio	1236|Gammaproteobacteria	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve,rve_3
k59_1784041_1	349124.Hhal_1765	4.79e-40	134.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,1S644@1236|Gammaproteobacteria,1WYJ8@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_1497700_1	991905.SL003B_1319	2.89e-110	355.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,4BPWR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EQ	Hydantoinase B/oxoprolinase	oplA	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
k59_1018311_1	1380347.JNII01000005_gene3264	5.21e-133	384.0	COG0346@1|root,COG0346@2|Bacteria,2GN2E@201174|Actinobacteria,4ETGE@85013|Frankiales	201174|Actinobacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_1136733_1	713587.THITH_01990	1.27e-120	360.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k59_845926_1	977880.RALTA_A2890	2.11e-91	298.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,1K0VQ@119060|Burkholderiaceae	28216|Betaproteobacteria	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1784044_2	273075.Ta0629	7.96e-14	71.6	COG1013@1|root,arCOG01601@2157|Archaea,2XT3E@28890|Euryarchaeota,2426J@183967|Thermoplasmata	183967|Thermoplasmata	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1,1.2.7.7	ko:K00170,ko:K00187	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_271955_1	1226325.HMPREF1548_02206	7.27e-40	147.0	COG1680@1|root,COG1680@2|Bacteria,1TR9E@1239|Firmicutes,2480P@186801|Clostridia,36G4W@31979|Clostridiaceae	186801|Clostridia	V	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1855600_1	1265505.ATUG01000002_gene2174	1.67e-60	204.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WKYE@28221|Deltaproteobacteria,2MHUM@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA-2	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
k59_1855603_1	768671.ThimaDRAFT_2676	6.29e-38	142.0	COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1RPMH@1236|Gammaproteobacteria,1WXSN@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_975119_1	697282.Mettu_0112	2.8e-102	302.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,1RRVZ@1236|Gammaproteobacteria,1XEBI@135618|Methylococcales	135618|Methylococcales	S	Belongs to the BI1 family	-	-	-	ko:K19416	-	M00742	-	-	ko00000,ko00002,ko02000	1.A.14.2.1	-	-	Bax1-I
k59_728463_1	1385935.N836_24965	2.16e-13	80.9	COG2199@1|root,COG5002@1|root,COG3706@2|Bacteria,COG5002@2|Bacteria,1GQ1T@1117|Cyanobacteria,1HHSH@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,Response_reg
k59_728463_2	1163409.UUA_07944	3.59e-40	140.0	COG0745@1|root,COG0745@2|Bacteria,1RA00@1224|Proteobacteria,1S23N@1236|Gammaproteobacteria,1X3BY@135614|Xanthomonadales	135614|Xanthomonadales	K	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_1497711_1	177437.HRM2_18150	5.52e-47	162.0	COG0535@1|root,COG0535@2|Bacteria,1RG5U@1224|Proteobacteria,42RKR@68525|delta/epsilon subdivisions,2WNUX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
k59_1865929_1	1082933.MEA186_30901	1.73e-93	313.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_1504205_1	234267.Acid_3964	3.83e-21	95.1	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y7IX@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	HAMP,Pkinase
k59_1504205_2	713586.KB900536_gene2578	1.13e-53	178.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
k59_788343_1	1386089.N865_07520	2.16e-110	334.0	28HJF@1|root,2Z7UK@2|Bacteria,2ICK7@201174|Actinobacteria,4FIJ9@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1439762_1	1267005.KB911257_gene711	2.68e-113	340.0	COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2TQXW@28211|Alphaproteobacteria,3N850@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	PHB de-polymerase C-terminus	phaZ	-	3.1.1.75	ko:K05973	ko00650,map00650	-	R05118	-	ko00000,ko00001,ko01000	-	-	-	PHB_depo_C
k59_926355_1	266264.Rmet_1281	2.23e-106	319.0	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,2VH3K@28216|Betaproteobacteria,1K3J9@119060|Burkholderiaceae	28216|Betaproteobacteria	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
k59_788348_1	349124.Hhal_1210	1.02e-37	140.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1WVW7@135613|Chromatiales	135613|Chromatiales	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_1865943_1	1110697.NCAST_05_04420	1.91e-79	256.0	COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria,4FTVZ@85025|Nocardiaceae	201174|Actinobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX,Transket_pyr,Transketolase_C,Transketolase_N
k59_985477_1	96561.Dole_0794	4.38e-88	273.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,43BQX@68525|delta/epsilon subdivisions,2X71W@28221|Deltaproteobacteria,2MIFV@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
k59_1439768_1	367299.JOEE01000005_gene3552	3.73e-125	375.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4FF7R@85021|Intrasporangiaceae	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_926362_1	96561.Dole_1667	1.59e-49	172.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria,2MIN7@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
k59_1269830_2	1123400.KB904747_gene610	2.04e-72	229.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,4620M@72273|Thiotrichales	72273|Thiotrichales	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
k59_1337684_1	1357275.AVEL02000033_gene2932	3.1e-62	202.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,1RNHI@1236|Gammaproteobacteria,1Z7DC@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564	-	-	-	-	-	-	-	-	-	-	APH
k59_1379725_1	1479235.KK366039_gene2492	7.83e-45	155.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1XH9U@135619|Oceanospirillales	135619|Oceanospirillales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_1379725_2	765910.MARPU_03835	1.33e-115	334.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,1WW34@135613|Chromatiales	135613|Chromatiales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_279526_1	1331060.RLDS_04095	2.94e-38	141.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TUMG@28211|Alphaproteobacteria,2K338@204457|Sphingomonadales	204457|Sphingomonadales	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.90	ko:K00055	ko00350,ko00360,ko00622,ko00623,ko01100,ko01120,ko01220,map00350,map00360,map00622,map00623,map01100,map01120,map01220	M00537,M00538	R01763,R02611,R04304,R05282,R05347,R05348	RC00087,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_499494_1	1005048.CFU_0897	4.14e-13	65.5	2EKIA@1|root,33E87@2|Bacteria,1NNCS@1224|Proteobacteria,2VYAC@28216|Betaproteobacteria,474ZJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_616682_1	1121378.KB899708_gene1187	3.31e-95	296.0	COG0554@1|root,COG0554@2|Bacteria,1WI6Q@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_206443_1	1187851.A33M_3642	2.02e-67	208.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,2U70Y@28211|Alphaproteobacteria,3FD5F@34008|Rhodovulum	28211|Alphaproteobacteria	L	Conserved hypothetical protein 95	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
k59_1337690_1	595460.RRSWK_01400	5.43e-54	184.0	COG3547@1|root,COG3547@2|Bacteria,2J46U@203682|Planctomycetes	203682|Planctomycetes	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_20
k59_46601_1	335543.Sfum_0378	8.63e-139	404.0	COG0683@1|root,COG0683@2|Bacteria,1MX94@1224|Proteobacteria,42PYP@68525|delta/epsilon subdivisions,2WMA1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_1674727_1	314256.OG2516_15329	1.43e-33	133.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2PD06@252301|Oceanicola	28211|Alphaproteobacteria	P	Heavy-metal-associated domain	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_788363_1	572477.Alvin_0969	1.74e-133	402.0	COG0466@1|root,COG0466@2|Bacteria,1NTR5@1224|Proteobacteria,1RPID@1236|Gammaproteobacteria,1WWG2@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1504249_1	471853.Bcav_2909	6.24e-58	188.0	COG0613@1|root,COG0613@2|Bacteria,2GNAP@201174|Actinobacteria	201174|Actinobacteria	S	PHP domain	PPA1328	-	3.1.3.97,3.1.4.57	ko:K07053,ko:K20859	ko00440,map00440	-	R00188,R10972,R10973,R11188	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	PHP
k59_46606_1	1123261.AXDW01000018_gene780	7.44e-49	166.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1X3UD@135614|Xanthomonadales	135614|Xanthomonadales	H	Belongs to the prokaryotic GSH synthase family	gshB	GO:0003674,GO:0003824,GO:0004363,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
k59_1337704_2	765912.Thimo_0724	4.76e-48	167.0	COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,1RQ6M@1236|Gammaproteobacteria,1X2WY@135613|Chromatiales	135613|Chromatiales	I	Belongs to the CDS family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
k59_616695_1	765910.MARPU_02820	1.86e-49	162.0	COG5456@1|root,COG5456@2|Bacteria,1RFTY@1224|Proteobacteria,1S4W0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	PFAM FixH	-	-	-	-	-	-	-	-	-	-	-	-	FixH
k59_1379746_1	311402.Avi_3900	2.83e-37	141.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2TSZN@28211|Alphaproteobacteria,4B87U@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
k59_206459_1	215803.DB30_7910	6.31e-59	192.0	COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,42R8E@68525|delta/epsilon subdivisions,2WN6V@28221|Deltaproteobacteria,2YZHF@29|Myxococcales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1141835_1	65497.JODV01000010_gene2654	1.76e-60	198.0	COG0657@1|root,COG0657@2|Bacteria,2GJYR@201174|Actinobacteria,4E1XX@85010|Pseudonocardiales	201174|Actinobacteria	I	alpha/beta hydrolase fold	lipW	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
k59_616697_1	1395571.TMS3_0104735	2.76e-59	209.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyltransferase,Aminotran_1_2,NAD_binding_4,PP-binding,Thioesterase
k59_104464_1	83219.PM02_02485	5.35e-23	105.0	COG2114@1|root,COG2770@1|root,COG2114@2|Bacteria,COG2770@2|Bacteria,1QVNT@1224|Proteobacteria,2TWID@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
k59_926415_1	1206743.BAGM01000035_gene80	5.76e-36	140.0	COG3321@1|root,COG3321@2|Bacteria,2H477@201174|Actinobacteria,4FU0A@85025|Nocardiaceae	201174|Actinobacteria	Q	Acyl transferase domain in polyketide synthase (PKS) enzymes.	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2,Acyl_transf_1,Docking,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
k59_323703_1	1713.JOFV01000008_gene3257	1.43e-194	553.0	COG0232@1|root,COG0232@2|Bacteria,2GJ8F@201174|Actinobacteria,4F0ZB@85016|Cellulomonadaceae	201174|Actinobacteria	F	Belongs to the dGTPase family. Type 2 subfamily	dgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_323703_2	471853.Bcav_1788	5e-140	415.0	COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria	201174|Actinobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
k59_1865996_1	935863.AWZR01000006_gene1226	4.08e-129	380.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1X3AN@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1865996_2	935863.AWZR01000006_gene1225	4.31e-36	123.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,1S8X4@1236|Gammaproteobacteria,1X7EF@135614|Xanthomonadales	135614|Xanthomonadales	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
k59_1095572_1	670307.HYPDE_30423	5.46e-72	233.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,2TR89@28211|Alphaproteobacteria,3N64S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_499524_2	566466.NOR53_52	1.63e-78	244.0	COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,1RNUH@1236|Gammaproteobacteria,1J7FF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	yejE	-	-	ko:K13895	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1
k59_398014_1	439235.Dalk_1819	8.76e-24	99.4	COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42PH3@68525|delta/epsilon subdivisions,2WJZH@28221|Deltaproteobacteria,2MIN0@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
k59_398014_2	643562.Daes_0789	3e-26	105.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M97@68525|delta/epsilon subdivisions,2WJB4@28221|Deltaproteobacteria,2MEMH@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DmsC,Fer4_11,Fer4_4
k59_1674750_1	439235.Dalk_1839	3.19e-21	94.0	COG5012@1|root,COG5012@2|Bacteria,1RE0V@1224|Proteobacteria,42VZ0@68525|delta/epsilon subdivisions,2WRFJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM cobalamin B12-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
k59_851871_1	323261.Noc_1667	1.64e-62	201.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1WWWT@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_851871_2	1101195.Meth11DRAFT_1222	1.15e-25	105.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2VI25@28216|Betaproteobacteria,2KMA0@206350|Nitrosomonadales	206350|Nitrosomonadales	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_147883_1	436229.JOEH01000048_gene6895	2.36e-34	119.0	COG3856@1|root,COG3856@2|Bacteria,2IKJW@201174|Actinobacteria,2NJ6T@228398|Streptacidiphilus	201174|Actinobacteria	S	Protein of unknown function (DUF1290)	sbp	-	-	-	-	-	-	-	-	-	-	-	DUF1290
k59_147883_2	471853.Bcav_2103	1.69e-67	218.0	COG3879@1|root,COG3879@2|Bacteria,2GJ3C@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF881
k59_1095584_1	768671.ThimaDRAFT_4246	6.96e-26	102.0	COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,1RPKU@1236|Gammaproteobacteria,1WWWI@135613|Chromatiales	135613|Chromatiales	U	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
k59_398028_1	593907.Celgi_0779	6.77e-74	233.0	COG0812@1|root,COG0812@2|Bacteria,2GIV2@201174|Actinobacteria,4F0UE@85016|Cellulomonadaceae	201174|Actinobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
k59_279583_1	1166948.JPZL01000002_gene1656	2.11e-65	214.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1XHR4@135619|Oceanospirillales	135619|Oceanospirillales	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_104495_1	525897.Dbac_1840	1.89e-83	263.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,42TI5@68525|delta/epsilon subdivisions,2WQR8@28221|Deltaproteobacteria,2MG9C@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_1095587_1	1035308.AQYY01000002_gene992	4.82e-106	316.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,2600U@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
k59_788390_1	765910.MARPU_11245	1.02e-38	139.0	COG0671@1|root,COG0671@2|Bacteria,1NAJ7@1224|Proteobacteria,1SDY6@1236|Gammaproteobacteria,1WW8C@135613|Chromatiales	135613|Chromatiales	I	PFAM phosphoesterase PA-phosphatase related	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
k59_788390_2	631362.Thi970DRAFT_04738	3.11e-08	55.1	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1RMA2@1236|Gammaproteobacteria,1WXJP@135613|Chromatiales	135613|Chromatiales	M	PFAM glycosyl transferase family 39	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_1866027_1	592029.DDD_1353	5.75e-06	50.8	COG3735@1|root,COG3735@2|Bacteria,4NGNW@976|Bacteroidetes,1HYQT@117743|Flavobacteriia,3HKWR@363408|Nonlabens	976|Bacteroidetes	S	TraB family	-	-	-	-	-	-	-	-	-	-	-	-	TraB
k59_1866027_2	754477.Q7C_2652	2.83e-38	137.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,1RNEN@1236|Gammaproteobacteria,461RI@72273|Thiotrichales	72273|Thiotrichales	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_985568_1	323261.Noc_2673	6.3e-76	236.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1WX5A@135613|Chromatiales	135613|Chromatiales	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_676194_1	1229781.C272_15692	1.01e-83	258.0	COG4912@1|root,COG4912@2|Bacteria,2GNQD@201174|Actinobacteria,4F964@85019|Brevibacteriaceae	201174|Actinobacteria	L	DNA alkylation repair enzyme	alkD	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
k59_1440595_1	1429916.X566_00575	1.68e-92	273.0	COG3415@1|root,COG3415@2|Bacteria,1RDMQ@1224|Proteobacteria,2U7PU@28211|Alphaproteobacteria,3K38Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,HTH_32,HTH_33
k59_1440595_2	1429916.X566_00580	3.43e-108	313.0	COG3335@1|root,COG3335@2|Bacteria,1RDBN@1224|Proteobacteria,2VFA9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	transposable element conserved	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_1675552_1	316067.Geob_1014	1.96e-45	164.0	COG3005@1|root,COG3005@2|Bacteria,1R956@1224|Proteobacteria,42Q0X@68525|delta/epsilon subdivisions,2WMHI@28221|Deltaproteobacteria,43U0A@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
k59_47934_1	1121405.dsmv_2542	2.91e-113	342.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1MUI0@1224|Proteobacteria,42MCB@68525|delta/epsilon subdivisions,2WIRJ@28221|Deltaproteobacteria,2MISA@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Belongs to the precorrin methyltransferase family	hemD	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
k59_986804_1	2340.JV46_24280	1.36e-96	304.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria,1J9A4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	hypF	GO:0003674,GO:0003824,GO:0005488,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016740,GO:0016741,GO:0016743,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0046944,GO:0051604,GO:0071704,GO:1901564	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_207264_2	1128421.JAGA01000002_gene784	5.19e-47	166.0	COG0403@1|root,COG0403@2|Bacteria,2NNP1@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
k59_207265_1	1118235.CAJH01000028_gene2004	3.42e-89	288.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1X45Q@135614|Xanthomonadales	135614|Xanthomonadales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1556441_1	1265505.ATUG01000001_gene3609	1.31e-49	175.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria,2MI8R@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_500319_1	498211.CJA_1795	3.37e-57	187.0	2CH0A@1|root,2ZANK@2|Bacteria,1R6U4@1224|Proteobacteria,1RQ3J@1236|Gammaproteobacteria,1FH4J@10|Cellvibrio	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1789844_1	568706.BN118_0363	3.87e-70	225.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2VHDZ@28216|Betaproteobacteria,3T1NI@506|Alcaligenaceae	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1789844_2	1070319.CAGGBEG34_200045	7.71e-39	137.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2VJBW@28216|Betaproteobacteria,1K209@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_1505257_1	1049564.TevJSym_an00750	5.41e-68	212.0	COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,1J5U7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis	rnt	GO:0000287,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360	-	ko:K03683	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_T
k59_1505257_2	2340.JV46_28900	3.23e-12	62.8	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,1J68E@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the glutaredoxin family. Monothiol subfamily	grxD	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
k59_852644_1	768671.ThimaDRAFT_4243	2.68e-15	74.3	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,1RQ50@1236|Gammaproteobacteria,1WWA9@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD dependent oxidoreductase	-	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
k59_986827_1	880072.Desac_1181	1.14e-158	471.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.6	ko:K01535,ko:K12955	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.24,3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_1505262_1	926556.Echvi_3214	6.2e-79	263.0	COG3696@1|root,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,47T9M@768503|Cytophagia	976|Bacteroidetes	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787,ko:K15726	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.2,2.A.6.1.4	-	-	ACR_tran
k59_1732898_1	1499967.BAYZ01000080_gene949	1.64e-98	301.0	COG0112@1|root,COG0112@2|Bacteria,2NP28@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	iG2583_1286.G2583_3081	SHMT
k59_1142534_1	1239962.C943_01303	2.75e-84	266.0	COG5361@1|root,COG5361@2|Bacteria,4NKSK@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1096522_1	298654.FraEuI1c_0705	8.12e-76	245.0	COG1217@1|root,COG1217@2|Bacteria,2GJUJ@201174|Actinobacteria,4ES8A@85013|Frankiales	201174|Actinobacteria	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_1867314_1	590998.Celf_2220	2.17e-84	257.0	2DBPK@1|root,2ZA9M@2|Bacteria,2I87Y@201174|Actinobacteria,4F1Z5@85016|Cellulomonadaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4191)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4191
k59_1867314_2	1386089.N865_07440	4.3e-28	108.0	COG1714@1|root,COG1714@2|Bacteria,2IQMG@201174|Actinobacteria,4FHT2@85021|Intrasporangiaceae	201174|Actinobacteria	S	PFAM RDD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	RDD
k59_1023981_1	205922.Pfl01_4015	9.16e-52	172.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,1RMG1@1236|Gammaproteobacteria,1YP9W@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	Q	ABC transporter, ATP-binding protein	ybbA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1556458_1	2074.JNYD01000015_gene4443	2.59e-14	72.8	COG0313@1|root,COG0313@2|Bacteria,2GJ9Q@201174|Actinobacteria,4DXGC@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_1556458_2	446469.Sked_30390	1.32e-75	231.0	COG1335@1|root,COG1335@2|Bacteria,2IFQW@201174|Actinobacteria	201174|Actinobacteria	Q	Pfam Isochorismatase	pncA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
k59_1306148_2	765914.ThisiDRAFT_1911	3.61e-36	128.0	COG2891@1|root,COG2891@2|Bacteria,1RER7@1224|Proteobacteria,1S8VI@1236|Gammaproteobacteria,1WYH2@135613|Chromatiales	135613|Chromatiales	M	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins	-	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
k59_1245037_1	1254432.SCE1572_07660	1.31e-46	167.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2YU1G@29|Myxococcales	28221|Deltaproteobacteria	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_1834353_1	335543.Sfum_0018	5.66e-36	124.0	COG1146@1|root,COG1146@2|Bacteria,1N0QV@1224|Proteobacteria,42U2Z@68525|delta/epsilon subdivisions,2WR58@28221|Deltaproteobacteria,2MS46@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7
k59_953987_1	1121106.JQKB01000156_gene817	7.31e-107	321.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2U2G6@28211|Alphaproteobacteria,2JVRW@204441|Rhodospirillales	204441|Rhodospirillales	L	Transposase IS116/IS110/IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_16767_1	1121935.AQXX01000132_gene2686	3.44e-196	564.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1XICM@135619|Oceanospirillales	135619|Oceanospirillales	V	(ABC) transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_250376_2	977880.RALTA_B1886	5.55e-46	161.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2VPV5@28216|Betaproteobacteria,1K3I9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_73261_1	639283.Snov_0309	1.35e-34	127.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2TQMD@28211|Alphaproteobacteria,3EY86@335928|Xanthobacteraceae	28211|Alphaproteobacteria	GM	NmrA-like family	MA20_24380	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	3Beta_HSD,Epimerase,NAD_binding_10,RmlD_sub_bind
k59_596740_1	1038860.AXAP01000018_gene3119	9.51e-11	67.8	COG3673@1|root,COG3673@2|Bacteria,1NFRW@1224|Proteobacteria,2TQTY@28211|Alphaproteobacteria,3JT8P@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterized alpha/beta hydrolase domain (DUF2235)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2235
k59_1711999_1	1089453.GOSPT_141_00050	5.48e-08	53.1	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4GAZ8@85026|Gordoniaceae	201174|Actinobacteria	H	Citrate synthase, C-terminal domain	gltA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_895025_2	1123400.KB904769_gene2854	1.68e-26	102.0	COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,1S5XY@1236|Gammaproteobacteria,460VS@72273|Thiotrichales	72273|Thiotrichales	S	PFAM Uncharacterised protein family (UPF0093)	-	-	-	ko:K08973	-	-	-	-	ko00000	-	-	-	UPF0093
k59_420690_1	1386089.N865_00505	8.11e-100	296.0	COG1082@1|root,COG1082@2|Bacteria,2GJKJ@201174|Actinobacteria,4FG6M@85021|Intrasporangiaceae	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	iolE	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
k59_127733_1	177437.HRM2_32050	1.33e-13	70.1	COG3086@1|root,COG3086@2|Bacteria,1PKXC@1224|Proteobacteria,42UU9@68525|delta/epsilon subdivisions,2WPMZ@28221|Deltaproteobacteria,2MK8X@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM Positive regulator of sigma(E) RseC MucC	-	-	-	ko:K03803	-	-	-	-	ko00000,ko03021	-	-	-	RseC_MucC
k59_127733_2	706587.Desti_4266	1.86e-33	125.0	COG1143@1|root,COG1143@2|Bacteria,1R412@1224|Proteobacteria,42ND5@68525|delta/epsilon subdivisions,2WIR2@28221|Deltaproteobacteria,2MQSB@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1480115_1	1386089.N865_19270	2.54e-84	269.0	COG1299@1|root,COG1445@1|root,COG1762@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,COG1762@2|Bacteria,2GJU4@201174|Actinobacteria,4FG55@85021|Intrasporangiaceae	201174|Actinobacteria	G	Phosphotransferase system, EIIC	fruA	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2,PTS_EIIC,PTS_IIB
k59_1480115_2	644284.Arch_1461	6.97e-08	50.8	COG1925@1|root,COG1925@2|Bacteria,2GQX6@201174|Actinobacteria,4D61C@85005|Actinomycetales	201174|Actinobacteria	G	phosphocarrier, HPr family	ptsH	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
k59_954024_1	1249627.D779_2230	8.11e-72	228.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1WVYI@135613|Chromatiales	135613|Chromatiales	G	PFAM Nucleotidyl transferase	-	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_127734_1	519989.ECTPHS_03854	2.27e-157	496.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_366804_1	768671.ThimaDRAFT_4701	2.68e-64	219.0	COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria,1WX8D@135613|Chromatiales	135613|Chromatiales	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_895043_1	314275.MADE_1010790	2.37e-14	68.9	2E5B0@1|root,33033@2|Bacteria,1ND0X@1224|Proteobacteria,1SEBX@1236|Gammaproteobacteria,46BYG@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_895043_2	1123517.JOMR01000001_gene1517	4.66e-09	56.6	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,1S23A@1236|Gammaproteobacteria,460IF@72273|Thiotrichales	72273|Thiotrichales	JM	PFAM Nucleotidyl transferase	-	-	2.7.7.99	ko:K00992	ko00520,ko01100,map00520,map01100	-	R11025	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
k59_1712008_2	446469.Sked_18280	6.23e-34	122.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	merR2	-	-	-	-	-	-	-	-	-	-	-	MerR_1
k59_954027_1	2340.JV46_13030	1.42e-177	499.0	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,1S7ID@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_250436_1	768671.ThimaDRAFT_3828	1.31e-106	343.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1WX9H@135613|Chromatiales	135613|Chromatiales	C	pyruvate flavodoxin ferredoxin oxidoreductase	-	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1245090_1	1246445.ANAY01000006_gene3765	8.32e-77	248.0	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria,4EI3M@85012|Streptosporangiales	201174|Actinobacteria	G	Alpha-amylase domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_303421_1	582744.Msip34_1997	8.94e-46	151.0	COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,2VR9K@28216|Betaproteobacteria,2KMR5@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
k59_303421_2	765913.ThidrDRAFT_0510	8.27e-32	117.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1WWSM@135613|Chromatiales	135613|Chromatiales	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_1306209_1	102125.Xen7305DRAFT_00004000	3.87e-18	88.6	COG3659@1|root,COG3659@2|Bacteria	2|Bacteria	M	wide pore channel activity	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB
k59_16841_1	765914.ThisiDRAFT_0027	2.66e-64	198.0	COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S4CZ@1236|Gammaproteobacteria,1WY6S@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_16841_2	1198452.Jab_2c16710	2.13e-18	85.5	COG2199@1|root,COG2204@1|root,COG2204@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2W8YT@28216|Betaproteobacteria,476D8@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_4,Response_reg
k59_16843_1	292415.Tbd_1520	9.2e-47	163.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,2VI7V@28216|Betaproteobacteria,1KRDQ@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Domain of unknown function (DUF1730)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
k59_16843_2	105559.Nwat_0753	9.57e-12	65.1	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1WW2E@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
k59_538363_1	1175629.AJTG01000005_gene768	7.75e-25	101.0	COG2231@1|root,COG2231@2|Bacteria,1V4SG@1239|Firmicutes,4HI5U@91061|Bacilli,27ES8@186827|Aerococcaceae	91061|Bacilli	L	endonuclease III	nth2	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
k59_1480963_1	518766.Rmar_1348	1.84e-15	82.8	COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1FIP6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1654894_1	75379.Tint_0713	3.99e-76	243.0	COG1275@1|root,COG1275@2|Bacteria,1MVPG@1224|Proteobacteria,2VKP1@28216|Betaproteobacteria,1KJCH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	C4-dicarboxylate transporter malic acid transport protein	-	-	-	ko:K03304	-	-	-	-	ko00000,ko02000	2.A.16.1	-	-	SLAC1
k59_251582_1	56780.SYN_02946	1.39e-50	177.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WK44@28221|Deltaproteobacteria,2MQ56@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	MFS_1,OEP
k59_303970_1	187272.Mlg_1018	5e-100	310.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1WXYV@135613|Chromatiales	135613|Chromatiales	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	mltF	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
k59_954806_1	443144.GM21_0509	7.4e-73	233.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1654896_1	2340.JV46_13800	4.37e-46	151.0	COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,1S8XH@1236|Gammaproteobacteria,1J6QP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1393 Arsenate reductase and related proteins, glutaredoxin family	arsC	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
k59_1770979_1	1187848.AJYQ01000003_gene410	3.24e-145	423.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGA@1236|Gammaproteobacteria,1XXNF@135623|Vibrionales	135623|Vibrionales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1712516_1	765912.Thimo_2100	2.11e-36	131.0	COG0457@1|root,COG0457@2|Bacteria,1N3T7@1224|Proteobacteria,1SFI0@1236|Gammaproteobacteria,1WY1U@135613|Chromatiales	135613|Chromatiales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
k59_1712516_2	765912.Thimo_2099	6.51e-95	297.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1WWG0@135613|Chromatiales	135613|Chromatiales	L	Helicase	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
k59_367571_1	290512.Paes_0726	1.5e-111	337.0	COG1236@1|root,COG1236@2|Bacteria,1FER3@1090|Chlorobi	1090|Chlorobi	J	PFAM beta-lactamase domain protein	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
k59_1420130_2	1469245.JFBG01000038_gene1806	2.54e-19	86.3	COG1117@1|root,COG1117@2|Bacteria	2|Bacteria	P	ATPase-coupled phosphate ion transmembrane transporter activity	pstB	-	3.6.3.27,3.6.3.55	ko:K02036,ko:K06857	ko02010,map02010	M00186,M00222	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4,3.A.1.7	-	-	ABC_tran
k59_1006970_1	1267005.KB911258_gene128	3.68e-118	362.0	COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,2TTSC@28211|Alphaproteobacteria,3N6GP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Tex-like protein N-terminal domain	tex	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
k59_895836_1	1385520.N802_14485	2.21e-40	153.0	COG2931@1|root,COG2931@2|Bacteria,2GKS7@201174|Actinobacteria,4FFUE@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,HemolysinCabind,Peptidase_M91,fn3
k59_954815_1	1249627.D779_0916	3.31e-66	223.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1WXQN@135613|Chromatiales	135613|Chromatiales	EQ	PFAM Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k59_597313_1	1123401.JHYQ01000005_gene176	5.06e-60	209.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,45ZSY@72273|Thiotrichales	72273|Thiotrichales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_715348_1	367299.JOEE01000005_gene3435	1.04e-52	177.0	COG4825@1|root,COG4825@2|Bacteria,2GPAA@201174|Actinobacteria,4FE5T@85021|Intrasporangiaceae	201174|Actinobacteria	S	Thiamin pyrophosphokinase	-	-	-	-	-	-	-	-	-	-	-	-	TPPK_C
k59_715348_2	367299.JOEE01000005_gene3434	7.08e-21	91.3	COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria,4FEM6@85021|Intrasporangiaceae	201174|Actinobacteria	L	May be involved in recombinational repair of damaged DNA	recN	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
k59_1306971_1	123899.JPQP01000019_gene2730	3.2e-67	228.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,3T1NA@506|Alcaligenaceae	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	bepE_2	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1006980_1	631362.Thi970DRAFT_01937	2.74e-67	216.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RMVW@1236|Gammaproteobacteria,1WX6X@135613|Chromatiales	135613|Chromatiales	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_954838_1	420324.KI911999_gene8063	8.16e-16	77.0	2CDHC@1|root,32RXT@2|Bacteria,1N2M3@1224|Proteobacteria,2U77A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1070434_1	1304865.JAGF01000001_gene1024	2.29e-60	202.0	COG2966@1|root,COG3610@1|root,COG2966@2|Bacteria,COG3610@2|Bacteria,2HXZX@201174|Actinobacteria,4F25F@85016|Cellulomonadaceae	201174|Actinobacteria	S	Threonine/Serine exporter, ThrE	-	-	-	-	-	-	-	-	-	-	-	-	ThrE
k59_1835227_1	1049564.TevJSym_af00410	6.39e-130	381.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1J4DX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceF	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1835227_2	1247726.MIM_c19210	2.66e-23	99.4	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,2VIHA@28216|Betaproteobacteria,3T2C5@506|Alcaligenaceae	28216|Betaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceF	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_656715_1	519989.ECTPHS_01604	5.82e-16	82.4	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1WX73@135613|Chromatiales	135613|Chromatiales	M	PFAM Three-deoxy-D-manno-octulosonic-acid transferase	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N,Kdo
k59_1481021_1	670307.HYPDE_36623	1.08e-59	207.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,3N67I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_421326_1	645991.Sgly_2685	6.47e-60	209.0	COG3383@1|root,COG3383@2|Bacteria,1UI1F@1239|Firmicutes,25EAG@186801|Clostridia,260KC@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM formate dehydrogenase, alpha subunit	nuoG	-	1.17.1.10,1.6.5.3	ko:K00336,ko:K05299	ko00190,ko00680,ko00720,ko01100,ko01120,ko01200,map00190,map00680,map00720,map01100,map01120,map01200	M00144,M00377	R00134,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_656719_1	1385518.N798_00370	1.07e-13	67.0	2E37T@1|root,32Y7G@2|Bacteria,2HKU0@201174|Actinobacteria,4FHMR@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
k59_656719_2	367299.JOEE01000006_gene710	2.65e-30	111.0	COG4640@1|root,COG4640@2|Bacteria,2GSZE@201174|Actinobacteria,4FH41@85021|Intrasporangiaceae	201174|Actinobacteria	S	Interferon-induced transmembrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CD225
k59_1536435_1	267608.RSp1637	7.73e-37	137.0	COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,2VJ85@28216|Betaproteobacteria,1K347@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcription regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
k59_772069_1	1064537.AGSO01000007_gene3175	1.92e-17	86.3	COG3919@1|root,COG3919@2|Bacteria,2GM4D@201174|Actinobacteria,4FBXB@85020|Dermabacteraceae	201174|Actinobacteria	S	ATP-grasp domain	-	-	6.3.1.12	ko:K17810	-	-	-	-	ko00000,ko01000	-	-	-	CPSase_L_D2
k59_656721_1	414684.RC1_3949	1.82e-123	357.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2TRCF@28211|Alphaproteobacteria,2JQTW@204441|Rhodospirillales	204441|Rhodospirillales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	phbB	-	1.1.1.100,1.1.1.36	ko:K00023,ko:K00059	ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212	M00083,M00373,M00572	R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00103,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1007002_1	543913.D521_1147	2.3e-32	128.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2VHFX@28216|Betaproteobacteria	28216|Betaproteobacteria	J	RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL
k59_1307006_1	545276.KB898724_gene2063	1.57e-118	355.0	COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria,1X2EG@135613|Chromatiales	135613|Chromatiales	P	PUA-like domain	-	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
k59_1654957_1	1121033.AUCF01000014_gene1264	2.96e-37	134.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,2JR23@204441|Rhodospirillales	204441|Rhodospirillales	E	branched-chain amino acid transport	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
k59_1654957_2	1316936.K678_04221	2.23e-12	68.2	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria,2JPIB@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_954876_1	1177928.TH2_14667	3.35e-11	63.9	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2TSQ2@28211|Alphaproteobacteria,2JRD2@204441|Rhodospirillales	204441|Rhodospirillales	P	protein involved in response to NO	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
k59_954876_2	1121468.AUBR01000004_gene201	2.36e-14	75.5	COG3284@1|root,COG3284@2|Bacteria,1VHQN@1239|Firmicutes,25EB0@186801|Clostridia,42FFG@68295|Thermoanaerobacterales	186801|Clostridia	K	GAF modulated sigma54 specific transcriptional regulator, Fis family	-	-	-	ko:K21405	-	-	-	-	ko00000,ko03000	-	-	-	GAF,HTH_8,PAS,PAS_9,Sigma54_activat
k59_480175_2	631362.Thi970DRAFT_04447	3.73e-97	293.0	COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,1RZQ2@1236|Gammaproteobacteria,1WXSM@135613|Chromatiales	135613|Chromatiales	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_128418_1	1304865.JAGF01000001_gene2476	1.22e-116	360.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,2GJ0A@201174|Actinobacteria,4F0FS@85016|Cellulomonadaceae	201174|Actinobacteria	E	TIGRFAM glutamate synthase, NADH NADPH, small subunit	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,NAD_binding_1,Pyr_redox_2
k59_1255212_1	768671.ThimaDRAFT_4419	9.2e-88	282.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,1WWTA@135613|Chromatiales	135613|Chromatiales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1543531_1	1123355.JHYO01000019_gene1694	4.82e-76	244.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,2UPRJ@28211|Alphaproteobacteria,36Z8A@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AFOR_C,AFOR_N
k59_135464_1	1291050.JAGE01000001_gene3175	4.91e-16	84.0	COG4584@1|root,COG4584@2|Bacteria,1UW0T@1239|Firmicutes,24DDG@186801|Clostridia,3WRXH@541000|Ruminococcaceae	186801|Clostridia	L	PFAM integrase	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_964675_1	349521.HCH_05874	6.64e-48	166.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,1XIFQ@135619|Oceanospirillales	135619|Oceanospirillales	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1719533_1	321846.PS417_01955	1.5e-78	260.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	penicillin-binding protein 1A	mrcA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_1543535_1	365046.Rta_00130	2.14e-102	306.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2VJX2@28216|Betaproteobacteria,4ADRU@80864|Comamonadaceae	28216|Betaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	mdlA	-	5.1.2.2	ko:K01781	ko00627,ko01120,map00627,map01120	-	R03791,R04161	RC00998	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_311058_1	519989.ECTPHS_06482	7.88e-49	176.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1WWYN@135613|Chromatiales	135613|Chromatiales	U	type IV pilus secretin PilQ	-	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_1367658_1	765952.PUV_07640	1.29e-27	112.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,2JFRN@204428|Chlamydiae	204428|Chlamydiae	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	fadJ	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_1367658_2	1437425.CSEC_1674	3.22e-26	108.0	COG1960@1|root,COG1960@2|Bacteria,2JFSS@204428|Chlamydiae	204428|Chlamydiae	C	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1192249_1	448385.sce0655	3.12e-07	55.8	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42PPB@68525|delta/epsilon subdivisions,2X5YN@28221|Deltaproteobacteria,2YUEJ@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12
k59_1192249_3	1121405.dsmv_0138	1.01e-06	48.1	COG0745@1|root,COG0745@2|Bacteria,1NBQZ@1224|Proteobacteria,42V8P@68525|delta/epsilon subdivisions,2WS87@28221|Deltaproteobacteria,2MN9A@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_261856_1	446469.Sked_23790	2.02e-58	182.0	COG0347@1|root,COG0347@2|Bacteria,2IKN1@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the P(II) protein family	glnB	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043531,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
k59_261856_2	1713.JOFV01000004_gene3468	1.12e-14	74.3	COG0004@1|root,COG0004@2|Bacteria,2GIZK@201174|Actinobacteria,4F1S2@85016|Cellulomonadaceae	201174|Actinobacteria	P	Ammonium Transporter Family	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_27950_1	879212.DespoDRAFT_03650	1.47e-34	123.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,42UF8@68525|delta/epsilon subdivisions,2WR6W@28221|Deltaproteobacteria,2MKHJ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	RF-1 domain	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
k59_1255228_1	177437.HRM2_31500	1.03e-47	168.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,42MFX@68525|delta/epsilon subdivisions,2WJ91@28221|Deltaproteobacteria,2MIXG@213118|Desulfobacterales	28221|Deltaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_1255228_2	1121405.dsmv_0091	9.78e-12	60.8	2EINH@1|root,33CDW@2|Bacteria,1NN5W@1224|Proteobacteria,42XC5@68525|delta/epsilon subdivisions,2WT26@28221|Deltaproteobacteria,2MMA6@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1255228_3	933262.AXAM01000039_gene1153	1.83e-23	98.6	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2WJT7@28221|Deltaproteobacteria,2MI5B@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_1367663_1	1049564.TevJSym_bc00170	1.35e-116	345.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1J5M1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033817,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iAF1260.b1095,iAPECO1_1312.APECO1_176,iB21_1397.B21_01099,iBWG_1329.BWG_0943,iE2348C_1286.E2348C_1187,iEC042_1314.EC042_1165,iEC55989_1330.EC55989_1207,iECABU_c1320.ECABU_c13085,iECBD_1354.ECBD_2506,iECB_1328.ECB_01091,iECDH10B_1368.ECDH10B_1167,iECDH1ME8569_1439.ECDH1ME8569_1030,iECD_1391.ECD_01091,iECED1_1282.ECED1_1238,iECH74115_1262.ECH74115_1474,iECIAI1_1343.ECIAI1_1130,iECIAI39_1322.ECIAI39_2066,iECO103_1326.ECO103_1140,iECO111_1330.ECO111_1372,iECO26_1355.ECO26_1428,iECOK1_1307.ECOK1_1202,iECP_1309.ECP_1087,iECS88_1305.ECS88_1109,iECSE_1348.ECSE_1159,iECSF_1327.ECSF_0994,iECSP_1301.ECSP_1396,iECUMN_1333.ECUMN_1270,iECW_1372.ECW_m1203,iECs_1301.ECs1473,iEKO11_1354.EKO11_2739,iETEC_1333.ETEC_1160,iEcDH1_1363.EcDH1_2552,iEcE24377_1341.EcE24377A_1216,iEcSMS35_1347.EcSMS35_2032,iG2583_1286.G2583_1355,iJO1366.b1095,iJR904.b1095,iLF82_1304.LF82_0607,iNRG857_1313.NRG857_05280,iSF_1195.SF1099,iSFxv_1172.SFxv_1251,iS_1188.S1179,iUMN146_1321.UM146_11850,iWFL_1372.ECW_m1203,iY75_1357.Y75_RS05720,iZ_1308.Z1734,ic_1306.c1365	Ketoacyl-synt_C,ketoacyl-synt
k59_1845097_1	1005395.CSV86_21896	2.99e-10	64.3	COG1629@1|root,COG1629@2|Bacteria,1QV18@1224|Proteobacteria,1T2Q3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,STN,TonB_dep_Rec
k59_1316891_1	187272.Mlg_2225	1.35e-114	339.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1WWFJ@135613|Chromatiales	135613|Chromatiales	M	Arabinose 5-phosphate isomerase	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
k59_428319_1	928724.SacglDRAFT_02600	1.31e-08	55.5	COG0559@1|root,COG0559@2|Bacteria,2HDZ9@201174|Actinobacteria,4E2QY@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_428319_2	1380356.JNIK01000011_gene1989	1.68e-73	230.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4ESPS@85013|Frankiales	201174|Actinobacteria	E	High-affinity branched-chain amino acid transport protein (ABC superfamily	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_1662154_2	247634.GPB2148_926	5.33e-15	75.1	COG1228@1|root,COG1228@2|Bacteria	2|Bacteria	Q	imidazolonepropionase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1778075_2	1283300.ATXB01000001_gene587	1.8e-38	136.0	COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,1RR95@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
k59_604259_1	765912.Thimo_2230	3.72e-92	300.0	COG0841@1|root,COG4223@1|root,COG0841@2|Bacteria,COG4223@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW08@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1778077_2	593907.Celgi_0569	1.27e-06	50.1	2C8R0@1|root,32RMN@2|Bacteria,2HXX4@201174|Actinobacteria,4F1HB@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_487100_2	1249627.D779_1945	1.74e-21	86.7	2AHT8@1|root,3185S@2|Bacteria,1RH98@1224|Proteobacteria,1S7UG@1236|Gammaproteobacteria,1WY6X@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1367672_1	220664.PFL_1120	1.86e-29	118.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1YN59@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	L	Single-stranded-DNA-specific exonuclease RecJ	recJ	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_261884_1	296591.Bpro_5555	4.9e-71	231.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ9H@28216|Betaproteobacteria,4AC3U@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM ABC-1 domain protein	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
k59_1543558_1	1049564.TevJSym_bb00370	5.44e-15	77.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1J5V1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	signal transduction protein with a C-terminal ATPase domain	algZ	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
k59_1543558_2	396588.Tgr7_0033	6.95e-45	158.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1WWNX@135613|Chromatiales	135613|Chromatiales	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_428330_1	1265505.ATUG01000003_gene519	1.18e-14	80.9	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WKC0@28221|Deltaproteobacteria,2MN70@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
k59_1662169_1	1304883.KI912532_gene953	1.69e-81	263.0	COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,2VIV2@28216|Betaproteobacteria,2KVXE@206389|Rhodocyclales	206389|Rhodocyclales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_777871_1	1116472.MGMO_60c00070	9.54e-80	250.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,1XEKI@135618|Methylococcales	135618|Methylococcales	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
k59_311084_1	713586.KB900536_gene1698	1.53e-05	46.6	COG4769@1|root,COG4769@2|Bacteria,1RJIB@1224|Proteobacteria,1SBYC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Heptaprenyl diphosphate synthase component I	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	Hpre_diP_synt_I
k59_311084_2	1384054.N790_07690	6.15e-37	139.0	COG0810@1|root,COG0810@2|Bacteria,1R330@1224|Proteobacteria,1RQAX@1236|Gammaproteobacteria,1XCS6@135614|Xanthomonadales	135614|Xanthomonadales	M	Periplasmic protein TonB links inner and outer membranes	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
k59_261897_1	255470.cbdbA109	2.86e-52	186.0	COG0326@1|root,COG0326@2|Bacteria,2G9ND@200795|Chloroflexi	200795|Chloroflexi	O	Molecular chaperone. Has ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1719569_1	313624.NSP_30840	6.69e-63	206.0	COG3288@1|root,COG3288@2|Bacteria,1G1D1@1117|Cyanobacteria,1HJ2V@1161|Nostocales	1117|Cyanobacteria	C	PFAM Alanine dehydrogenase PNT, C-terminal domain	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_1130620_1	1197706.AKKK01000022_gene2243	6.71e-104	312.0	COG1216@1|root,COG1216@2|Bacteria,2IMYG@201174|Actinobacteria,1WA55@1268|Micrococcaceae	201174|Actinobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,PS_pyruv_trans
k59_1130620_2	1713.JOFV01000002_gene556	8.6e-35	131.0	COG0499@1|root,COG0499@2|Bacteria,2GK2Q@201174|Actinobacteria,4F0EM@85016|Cellulomonadaceae	201174|Actinobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0000098,GO:0000166,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009087,GO:0009116,GO:0009119,GO:0009987,GO:0016020,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0019899,GO:0022610,GO:0030260,GO:0030312,GO:0033353,GO:0034641,GO:0035375,GO:0035635,GO:0036094,GO:0040007,GO:0042278,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044650,GO:0046085,GO:0046128,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0048037,GO:0050662,GO:0051186,GO:0051287,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0055086,GO:0070403,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_964726_1	1304874.JAFY01000002_gene661	2.13e-51	174.0	COG0477@1|root,COG2814@2|Bacteria,3TACG@508458|Synergistetes	508458|Synergistetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_964726_2	335543.Sfum_1824	1.02e-08	55.5	COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,42R5Z@68525|delta/epsilon subdivisions,2WMPN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
k59_1490078_1	626939.HMPREF9443_02125	7.03e-21	92.4	COG1013@1|root,COG1013@2|Bacteria,1TQJ2@1239|Firmicutes,4H28P@909932|Negativicutes	909932|Negativicutes	C	thiamine pyrophosphate enzyme	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_1490078_2	1123009.AUID01000036_gene1240	1.23e-14	71.2	COG1014@1|root,COG1014@2|Bacteria,1V3RG@1239|Firmicutes,24I3Y@186801|Clostridia,26BKS@186813|unclassified Clostridiales	186801|Clostridia	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	korC	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
k59_722292_1	1304865.JAGF01000001_gene1644	3.32e-78	245.0	2B887@1|root,321GU@2|Bacteria,2H5II@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1543575_1	583355.Caka_2359	2.2e-33	127.0	COG0079@1|root,COG0079@2|Bacteria,46TNF@74201|Verrucomicrobia,3K73Y@414999|Opitutae	414999|Opitutae	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_28010_1	765910.MARPU_16695	3.43e-61	202.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,1WWCM@135613|Chromatiales	135613|Chromatiales	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
k59_428345_1	1217718.ALOU01000020_gene2205	4.49e-27	101.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,2VQ2I@28216|Betaproteobacteria,1K6Y7@119060|Burkholderiaceae	28216|Betaproteobacteria	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	iscU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
k59_604282_1	472759.Nhal_0511	4.13e-88	265.0	COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,1RYSQ@1236|Gammaproteobacteria,1X2G9@135613|Chromatiales	135613|Chromatiales	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
k59_83961_1	421052.F945_00901	4.27e-07	55.1	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,1SF1R@1236|Gammaproteobacteria,3NP0V@468|Moraxellaceae	1236|Gammaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_377540_1	555779.Dthio_PD1799	1.84e-53	190.0	COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2M8T9@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	ATPase BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
k59_663799_1	998674.ATTE01000001_gene4006	2.96e-51	174.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,46205@72273|Thiotrichales	72273|Thiotrichales	V	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
k59_663799_2	335543.Sfum_2391	3.75e-114	347.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WK9W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM ABC transporter	-	-	-	ko:K01990,ko:K01992,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC2_membrane_3,ABC_tran
k59_1719586_1	103690.17131831	3.26e-12	71.2	COG3221@1|root,COG3221@2|Bacteria,1G5J2@1117|Cyanobacteria,1HN2F@1161|Nostocales	1117|Cyanobacteria	P	Phosphonate ABC	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
k59_1427290_2	713587.THITH_11575	8.03e-89	273.0	COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,1RRKZ@1236|Gammaproteobacteria,1WWQA@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
k59_1719588_1	1454004.AW11_02153	2.04e-110	325.0	COG0348@1|root,COG0348@2|Bacteria,1MWR5@1224|Proteobacteria,2VJYI@28216|Betaproteobacteria	28216|Betaproteobacteria	C	TIGRFAM ferredoxin-type protein, NapH MauN family	napH	-	-	ko:K02574	-	-	-	-	ko00000	-	-	-	Fer4_10,Fer4_5,Fer4_6,Fer4_7,Fer4_9
k59_1778109_1	1122933.JNIY01000009_gene1371	3.73e-84	258.0	COG1011@1|root,COG1011@2|Bacteria,2GNSS@201174|Actinobacteria,4F152@85016|Cellulomonadaceae	201174|Actinobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant	-	-	3.1.3.102,3.1.3.104	ko:K07025,ko:K20862	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00548,R07280	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2
k59_1130636_2	1408422.JHYF01000002_gene2288	3.91e-06	51.2	COG1664@1|root,COG1664@2|Bacteria,1VEVU@1239|Firmicutes,24QT5@186801|Clostridia,36MUM@31979|Clostridiaceae	186801|Clostridia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_1316953_1	85643.Tmz1t_0548	4.06e-53	187.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VM2H@28216|Betaproteobacteria,2KVCG@206389|Rhodocyclales	206389|Rhodocyclales	L	COG0210 Superfamily I DNA and RNA helicases	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_664696_1	743718.Isova_1436	1.11e-28	118.0	COG0215@1|root,COG0215@2|Bacteria,2GJZR@201174|Actinobacteria,4F36U@85017|Promicromonosporaceae	201174|Actinobacteria	H	Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins	mshC	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iNJ661.Rv2130c	tRNA-synt_1e
k59_1256572_1	396588.Tgr7_0565	7.16e-76	233.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,1S23A@1236|Gammaproteobacteria,1WWYC@135613|Chromatiales	135613|Chromatiales	JM	PFAM Nucleotidyl transferase	-	-	2.7.7.99	ko:K00992	ko00520,ko01100,map00520,map01100	-	R11025	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
k59_1256572_2	1049564.TevJSym_at00710	2.67e-19	83.6	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,1J5UE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Necessary for normal cell division and for the maintenance of normal septation	engB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
k59_1082433_1	857087.Metme_2867	6.4e-08	60.1	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,1SCVJ@1236|Gammaproteobacteria,1XF4A@135618|Methylococcales	135618|Methylococcales	U	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
k59_605239_1	1201293.AKXQ01000023_gene4192	2.25e-09	63.5	2DCNX@1|root,2ZESX@2|Bacteria,1QUV9@1224|Proteobacteria,1RRBH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_546625_1	717785.HYPMC_2362	1.6e-71	231.0	COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,1MW8M@1224|Proteobacteria,2TUSJ@28211|Alphaproteobacteria,3N61U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_1368634_1	880073.Calab_3168	4.46e-63	213.0	COG2911@1|root,COG3291@1|root,COG2911@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	-
k59_778709_1	425104.Ssed_1779	4.18e-34	132.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RMKV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Amino Acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_1846359_1	443144.GM21_0439	3.67e-82	270.0	COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,43CT2@68525|delta/epsilon subdivisions,2X80K@28221|Deltaproteobacteria,43TUA@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
k59_965940_1	1150398.JIBJ01000003_gene1623	1.68e-20	93.2	COG0673@1|root,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria,1W9AJ@1268|Micrococcaceae	201174|Actinobacteria	C	oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_605245_1	446466.Cfla_3404	1.51e-84	259.0	COG4213@1|root,COG4213@2|Bacteria,2GKRE@201174|Actinobacteria,4F0VI@85016|Cellulomonadaceae	201174|Actinobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10546	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	Peripla_BP_4
k59_1368636_2	246197.MXAN_1840	4.02e-60	204.0	COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,42MUS@68525|delta/epsilon subdivisions,2WKK4@28221|Deltaproteobacteria,2YZBQ@29|Myxococcales	28221|Deltaproteobacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
k59_1193228_1	768671.ThimaDRAFT_0224	4.36e-53	184.0	COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,1RQIV@1236|Gammaproteobacteria,1X0HY@135613|Chromatiales	135613|Chromatiales	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
k59_1318212_1	156889.Mmc1_3087	3.21e-46	160.0	COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,2U1U3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_605254_1	1267005.KB911255_gene2629	8.43e-98	298.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria,3N890@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cysteine-rich domain	glcF	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7
k59_1602734_2	768671.ThimaDRAFT_3833	1.87e-101	298.0	COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,1WW9M@135613|Chromatiales	135613|Chromatiales	U	Part of a membrane complex involved in electron transport	-	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
k59_1602734_3	768671.ThimaDRAFT_3832	3.59e-60	191.0	COG4660@1|root,COG4660@2|Bacteria,1R342@1224|Proteobacteria,1T62W@1236|Gammaproteobacteria,1WW5Q@135613|Chromatiales	135613|Chromatiales	U	Part of a membrane complex involved in electron transport	-	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
k59_1428262_1	269799.Gmet_1936	9.41e-19	79.7	COG1722@1|root,COG1722@2|Bacteria,1Q1MM@1224|Proteobacteria,42X37@68525|delta/epsilon subdivisions,2WSNI@28221|Deltaproteobacteria,43VHI@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
k59_1428262_2	1123070.KB899259_gene2021	6.01e-22	93.6	COG0142@1|root,COG0142@2|Bacteria,46S62@74201|Verrucomicrobia,2IU28@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Polyprenyl synthetase	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_312099_1	948106.AWZT01000002_gene6454	1.29e-13	70.5	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,1JZW5@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Belongs to the thiolase family	atoB	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_312099_2	1163407.UU7_05224	3.13e-42	149.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1X3IG@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA	-	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1018036_2	67275.JOAP01000008_gene4021	1.93e-07	55.1	COG0494@1|root,COG0494@2|Bacteria,2GKG9@201174|Actinobacteria	201174|Actinobacteria	L	NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_1725822_1	572477.Alvin_2486	1.85e-06	51.6	COG0750@1|root,COG3016@1|root,COG0750@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,1RPWZ@1236|Gammaproteobacteria,1WX9T@135613|Chromatiales	135613|Chromatiales	O	smart pdz dhr glgf	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg,PDZ_2
k59_1725822_2	857087.Metme_4288	9.09e-68	212.0	292MF@1|root,2ZQ5C@2|Bacteria,1RCYR@1224|Proteobacteria,1S44V@1236|Gammaproteobacteria,1XF22@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3047)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3047
k59_728137_2	1380370.JIBA01000015_gene318	6.5e-06	49.3	COG1680@1|root,COG1680@2|Bacteria,2GK3A@201174|Actinobacteria,4FFEB@85021|Intrasporangiaceae	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_93670_1	234267.Acid_0438	7.91e-05	50.4	COG0664@1|root,COG4191@1|root,COG0664@2|Bacteria,COG4191@2|Bacteria,3Y99Q@57723|Acidobacteria	57723|Acidobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_493179_1	768671.ThimaDRAFT_0622	5.99e-49	176.0	COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,1RQWX@1236|Gammaproteobacteria,1WZGU@135613|Chromatiales	135613|Chromatiales	C	PFAM Glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_1783787_1	876044.IMCC3088_2535	1.66e-69	231.0	COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1T3IM@1236|Gammaproteobacteria,1J9GH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_1433493_1	933262.AXAM01000010_gene1386	3.95e-10	58.9	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,42U68@68525|delta/epsilon subdivisions,2WQJS@28221|Deltaproteobacteria,2MJKI@213118|Desulfobacterales	28221|Deltaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
k59_1433493_2	1121405.dsmv_0477	2.09e-24	101.0	COG0711@1|root,COG0711@2|Bacteria,1N97K@1224|Proteobacteria,42VYP@68525|delta/epsilon subdivisions,2WR6T@28221|Deltaproteobacteria,2MK1E@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
k59_141421_1	349521.HCH_04586	3.02e-26	107.0	28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria,1XHP8@135619|Oceanospirillales	135619|Oceanospirillales	S	Protein of unknown function (DUF1329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1329
k59_141421_2	639030.JHVA01000001_gene1264	1.61e-31	119.0	COG3126@1|root,COG3187@1|root,COG3126@2|Bacteria,COG3187@2|Bacteria,3Y8W7@57723|Acidobacteria	57723|Acidobacteria	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META,YscW
k59_974531_1	944435.AXAJ01000001_gene392	6.05e-38	140.0	COG2391@1|root,COG2391@2|Bacteria,1PF9B@1224|Proteobacteria,2VKKD@28216|Betaproteobacteria,1K2C9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_1783789_1	743718.Isova_1739	7.33e-39	136.0	2E76N@1|root,331QJ@2|Bacteria,2ITA1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1668366_1	644282.Deba_2225	1.74e-44	150.0	COG4656@1|root,COG4656@2|Bacteria,1MWAX@1224|Proteobacteria,42NJM@68525|delta/epsilon subdivisions,2WJJB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Methylene-tetrahydrofolate reductase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR_C
k59_1668366_2	1265505.ATUG01000001_gene3027	2.06e-56	177.0	COG1908@1|root,COG1908@2|Bacteria,1MZ7V@1224|Proteobacteria,42UHS@68525|delta/epsilon subdivisions,2WQMX@28221|Deltaproteobacteria,2MNI6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
k59_1373435_1	314278.NB231_05601	2.42e-81	256.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,1WWCK@135613|Chromatiales	135613|Chromatiales	M	Peptidoglycan polymerase that is essential for cell division	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_1326719_1	1348635.BBJY01000015_gene669	5.22e-35	124.0	COG0818@1|root,COG0818@2|Bacteria,1MZ3Q@1224|Proteobacteria,1S92I@1236|Gammaproteobacteria,1XXSV@135623|Vibrionales	135623|Vibrionales	M	Recycling of diacylglycerol produced during the turnover of membrane phospholipid	dgkA	-	2.7.1.107	ko:K00901	ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_prokar
k59_974541_1	380358.XALC_1281	8.05e-14	73.2	COG4970@1|root,COG4970@2|Bacteria	2|Bacteria	NU	protein transport across the cell outer membrane	fimT	-	-	ko:K08084	-	-	-	-	ko00000,ko02044	3.A.15.2	-	-	GspH,N_methyl
k59_38214_1	1454010.JEOE01000002_gene369	4e-118	356.0	COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria,4F0ST@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_783780_1	1416759.AYMR01000027_gene1408	1.16e-108	358.0	COG1749@1|root,COG1749@2|Bacteria,2I2X3@201174|Actinobacteria,4FR1T@85023|Microbacteriaceae	201174|Actinobacteria	N	Bacterial Ig-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082,Mo-co_dimer,fn3
k59_1669105_1	1266925.JHVX01000001_gene2488	2.73e-108	333.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,3725U@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Cytochrome c-type biogenesis protein CcmF	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_1784423_1	1042375.AFPL01000016_gene78	7.28e-102	303.0	COG0702@1|root,COG0702@2|Bacteria,1MW44@1224|Proteobacteria,1RTF4@1236|Gammaproteobacteria,466DI@72275|Alteromonadaceae	1236|Gammaproteobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
k59_200710_1	1168034.FH5T_18790	7.86e-46	167.0	COG1643@1|root,COG1643@2|Bacteria,4NFJ7@976|Bacteroidetes,2FWZ1@200643|Bacteroidia	976|Bacteroidetes	L	Helicase associated domain (HA2)  Add an annotation	-	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_1550037_1	991905.SL003B_3375	6.88e-84	264.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2TSFF@28211|Alphaproteobacteria,4BPWY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5,GDC-P
k59_1018685_1	472759.Nhal_2106	3.08e-80	243.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1RSPA@1236|Gammaproteobacteria,1WXV0@135613|Chromatiales	135613|Chromatiales	S	Cytokinin riboside 5'-monophosphate phosphoribohydrolase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_142166_1	450380.JPSY01000001_gene1109	4.41e-58	196.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria,4FMZR@85023|Microbacteriaceae	201174|Actinobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1137123_1	768671.ThimaDRAFT_3169	1.45e-12	71.6	2ESM0@1|root,33K5K@2|Bacteria,1N02H@1224|Proteobacteria,1SA2K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_552576_1	452637.Oter_0214	4.11e-15	72.4	COG0094@1|root,COG0094@2|Bacteria,46SP7@74201|Verrucomicrobia,3K7AF@414999|Opitutae	414999|Opitutae	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_552576_2	568703.LGG_02422	1.79e-30	110.0	COG0199@1|root,COG0199@2|Bacteria,1VEF6@1239|Firmicutes,4HKK1@91061|Bacilli,3F7KX@33958|Lactobacillaceae	91061|Bacilli	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
k59_200723_1	314278.NB231_08425	9.99e-59	195.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,1RS5D@1236|Gammaproteobacteria,1WXTX@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
k59_200723_2	1454004.AW11_02203	1.08e-52	182.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2VHBY@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Asparagine synthase	asnB1	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_95055_1	314278.NB231_13276	9.63e-16	75.9	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_95055_2	1385515.N791_03625	9.53e-40	143.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1X4F6@135614|Xanthomonadales	135614|Xanthomonadales	NU	twitching motility protein	pilU	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_272446_1	222534.KB893716_gene1860	1.03e-66	213.0	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria	201174|Actinobacteria	E	dehydrogenase	adh	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_272446_2	65497.JODV01000004_gene1456	3.29e-33	124.0	COG1396@1|root,COG1396@2|Bacteria,2GJS3@201174|Actinobacteria,4E0HY@85010|Pseudonocardiales	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
k59_916852_1	194867.ALBQ01000040_gene3153	1.97e-68	224.0	COG0793@1|root,COG0793@2|Bacteria,1MUA3@1224|Proteobacteria,2U1FI@28211|Alphaproteobacteria,2K0WR@204457|Sphingomonadales	204457|Sphingomonadales	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
k59_39100_1	28444.JODQ01000001_gene2680	8e-99	311.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,4EGSR@85012|Streptosporangiales	201174|Actinobacteria	D	Ftsk_gamma	ftsK	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_95066_1	314271.RB2654_09079	2.96e-74	246.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1042 Acyl-CoA synthetase (NDP forming)	MA20_38090	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1856451_2	314256.OG2516_08873	1.73e-60	207.0	COG0444@1|root,COG1173@1|root,COG0444@2|Bacteria,COG1173@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,2PCTN@252301|Oceanicola	28211|Alphaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02031,ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,BPD_transp_1,OppC_N,oligo_HPY
k59_975943_1	1121015.N789_08250	6.96e-79	246.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1X3IR@135614|Xanthomonadales	135614|Xanthomonadales	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,Iso_dh
k59_846421_1	1192759.AKIB01000047_gene868	4.63e-35	131.0	COG3547@1|root,COG3547@2|Bacteria,1Q4TE@1224|Proteobacteria,2TT7C@28211|Alphaproteobacteria,2K2T8@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1550062_2	1232410.KI421421_gene3309	3.06e-146	436.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2WJG7@28221|Deltaproteobacteria,43STK@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_200742_1	388051.AUFE01000003_gene728	7.48e-59	203.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria	28216|Betaproteobacteria	M	surface antigen variable number repeat protein	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k59_728948_1	880072.Desac_1263	6.6e-85	267.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42P0M@68525|delta/epsilon subdivisions,2WJMC@28221|Deltaproteobacteria,2MR1W@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	AMP-dependent synthetase and ligase	-	-	6.2.1.1,6.2.1.32	ko:K01895,ko:K08295	ko00010,ko00620,ko00627,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00627,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R00982,R01354	RC00004,RC00012,RC00043,RC00070,RC00174,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_611273_1	935840.JAEQ01000006_gene2617	4.19e-165	466.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,43IUV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_95095_1	1121405.dsmv_3645	1.93e-100	323.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2MI5C@213118|Desulfobacterales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_916882_1	765910.MARPU_09040	1.41e-57	187.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,1RQU0@1236|Gammaproteobacteria,1WW93@135613|Chromatiales	135613|Chromatiales	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_1669155_1	367299.JOEE01000006_gene830	1.1e-71	239.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4FFAH@85021|Intrasporangiaceae	201174|Actinobacteria	Q	ABC transporter	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_611275_1	32057.KB217481_gene8582	7.58e-32	115.0	COG3812@1|root,COG3812@2|Bacteria,1G61H@1117|Cyanobacteria,1HN2I@1161|Nostocales	1117|Cyanobacteria	S	Domain of unknown function (DUF1993)	-	-	-	ko:K09983	-	-	-	-	ko00000	-	-	-	DUF1993
k59_975977_1	225937.HP15_2665	1.13e-09	58.2	COG5488@1|root,COG5488@2|Bacteria,1N9B7@1224|Proteobacteria,1SF1J@1236|Gammaproteobacteria,46CDG@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Integral membrane protein (DUF2244)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2244
k59_975977_2	1894.JOER01000027_gene4472	3.98e-18	84.0	COG2897@1|root,COG2897@2|Bacteria,2GMDR@201174|Actinobacteria	201174|Actinobacteria	P	sulfurtransferase	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_1856492_3	861299.J421_0290	1.13e-17	85.5	COG0845@1|root,COG0845@2|Bacteria,1ZUP2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
k59_1784478_1	1211115.ALIQ01000052_gene2826	9.5e-08	54.7	COG4233@1|root,COG4233@2|Bacteria,1REVE@1224|Proteobacteria,2VEXK@28211|Alphaproteobacteria,3NB6J@45404|Beijerinckiaceae	28211|Alphaproteobacteria	CO	Disulphide bond corrector protein DsbC	-	-	-	-	-	-	-	-	-	-	-	-	DsbC
k59_1784478_2	107636.JQNK01000009_gene3649	7.79e-60	192.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2TTX4@28211|Alphaproteobacteria,36Y99@31993|Methylocystaceae	28211|Alphaproteobacteria	K	Uncharacterized ACR, COG1678	MA20_18155	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_1328201_1	765911.Thivi_3471	2.19e-66	211.0	COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,1RMUT@1236|Gammaproteobacteria,1WX1H@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
k59_388625_1	641491.DND132_2897	2.75e-39	148.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2M9JU@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_1374188_1	1713.JOFV01000002_gene576	5.41e-151	433.0	COG0562@1|root,COG0562@2|Bacteria,2GK2Z@201174|Actinobacteria,4F0WK@85016|Cellulomonadaceae	201174|Actinobacteria	M	UDP-galactopyranose mutase	glf	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008767,GO:0009273,GO:0009987,GO:0016020,GO:0016853,GO:0016866,GO:0030312,GO:0042546,GO:0044085,GO:0044464,GO:0071554,GO:0071766,GO:0071840,GO:0071944	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3809c	GLF,NAD_binding_8
k59_1434320_1	935839.JAGJ01000001_gene1263	2.96e-27	110.0	COG2314@1|root,COG2314@2|Bacteria,2HFED@201174|Actinobacteria,4F5XV@85017|Promicromonosporaceae	201174|Actinobacteria	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
k59_1856495_2	452637.Oter_2711	1.77e-13	69.7	COG1950@1|root,COG1950@2|Bacteria,46W1Z@74201|Verrucomicrobia,3K8BW@414999|Opitutae	414999|Opitutae	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
k59_1856495_3	1242864.D187_005060	0.000216	50.1	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_388633_1	96561.Dole_2483	1.86e-47	172.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MIJD@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1669169_1	395964.KE386496_gene398	5.58e-40	144.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,2TSPP@28211|Alphaproteobacteria,3N9W5@45404|Beijerinckiaceae	28211|Alphaproteobacteria	J	Initiation factor 2 subunit family	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
k59_916929_1	269796.Rru_A1931	2.45e-94	291.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2TRCR@28211|Alphaproteobacteria,2JSH9@204441|Rhodospirillales	204441|Rhodospirillales	C	Sulfite reductase	-	-	1.8.1.2	ko:K00381	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_670456_1	247639.MGP2080_08771	1.35e-137	400.0	COG3391@1|root,COG3391@2|Bacteria,1MXDX@1224|Proteobacteria,1S012@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	56kDa selenium binding protein (SBP56)	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
k59_1137187_1	926564.KI911627_gene3198	7.79e-94	286.0	COG1653@1|root,COG1653@2|Bacteria,2GNJW@201174|Actinobacteria,4F5DX@85017|Promicromonosporaceae	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
k59_1498199_1	196367.JNFG01000037_gene7586	4.43e-40	148.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,1K24M@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_D23
k59_200786_1	1207076.ALAT01000147_gene465	1.98e-38	131.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,1Z2VT@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	O	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
k59_611311_1	582899.Hden_1768	2.15e-88	271.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2TR04@28211|Alphaproteobacteria,3N69K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_494024_1	1049564.TevJSym_aq00480	3.06e-53	175.0	COG1047@1|root,COG1047@2|Bacteria,1RH9C@1224|Proteobacteria,1S63R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
k59_142257_1	1395571.TMS3_0104120	3.55e-25	104.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Ammonium transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_142257_2	296591.Bpro_0183	2.47e-22	89.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2VSEZ@28216|Betaproteobacteria,4AE4W@80864|Comamonadaceae	28216|Betaproteobacteria	K	Belongs to the P(II) protein family	glnK	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
k59_48990_2	83406.HDN1F_14510	1.67e-36	144.0	COG2199@1|root,COG3706@2|Bacteria,1QVPW@1224|Proteobacteria,1T2GC@1236|Gammaproteobacteria,1JAKM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_1271611_2	379731.PST_0096	4.02e-40	148.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1YZVE@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	gabD	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006105,GO:0006520,GO:0006536,GO:0006538,GO:0006540,GO:0006553,GO:0006554,GO:0006807,GO:0008150,GO:0008152,GO:0009013,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009068,GO:0009448,GO:0009450,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0019477,GO:0019752,GO:0032787,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046440,GO:0047949,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI39_1322.ECIAI39_2847,iYL1228.KPN_00256	Aldedh
k59_1441186_1	358220.C380_15335	4.34e-63	213.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2VIW3@28216|Betaproteobacteria,4ABSX@80864|Comamonadaceae	28216|Betaproteobacteria	C	NADH flavin oxidoreductase NADH oxidase	fadH	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
k59_1868276_1	439235.Dalk_3317	2.39e-67	214.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJUN@28221|Deltaproteobacteria,2MIK6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_618073_1	383372.Rcas_4308	3.2e-79	253.0	COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,2G7JD@200795|Chloroflexi,376A2@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
k59_1340058_1	367299.JOEE01000001_gene2049	3.02e-119	342.0	COG0377@1|root,COG0377@2|Bacteria,2GJXR@201174|Actinobacteria,4FFFN@85021|Intrasporangiaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_559452_1	880072.Desac_2134	1.16e-77	242.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,2MQFV@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	PFAM MotA TolQ ExbB proton channel	aglX	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
k59_1097169_1	870187.Thini_1228	1.81e-22	100.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1RZEA@1236|Gammaproteobacteria,462SF@72273|Thiotrichales	72273|Thiotrichales	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2
k59_1097169_2	987059.RBXJA2T_02422	9.82e-15	72.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2VU7C@28216|Betaproteobacteria,1KM3E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	subunit of a heme lyase	ccmH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
k59_149327_1	1123366.TH3_07907	4.98e-90	276.0	COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,2TVCB@28211|Alphaproteobacteria,2JQND@204441|Rhodospirillales	204441|Rhodospirillales	S	Cytochrome D1 heme domain	-	-	-	ko:K19345	-	-	-	-	ko00000	-	-	-	Cytochrom_D1
k59_559454_1	367299.JOEE01000004_gene1130	7.5e-113	335.0	COG0065@1|root,COG0065@2|Bacteria,2GKT7@201174|Actinobacteria,4FE5P@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_1505958_1	2340.JV46_27580	1.44e-123	379.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1RQK9@1236|Gammaproteobacteria,1J907@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	ttrA	-	1.8.5.5,1.8.5.6	ko:K08352,ko:K08357,ko:K21307	ko00920,ko01100,ko01120,ko02020,map00920,map01100,map01120,map02020	-	R10149,R10150,R11487	RC00168,RC02823,RC03109	ko00000,ko00001,ko01000,ko02000	5.A.3.10,5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_149329_1	713586.KB900536_gene427	3.13e-72	237.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_1024474_1	322710.Avin_39320	1.15e-61	194.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,1S3WJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Deacetylates O-acetyl-ADP ribose. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization activation	ymdB	GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0008150,GO:0008428,GO:0009892,GO:0010605,GO:0016787,GO:0019213,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0043086,GO:0043900,GO:0044092,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0061463,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:1900190,GO:1900231	-	-	-	-	-	-	-	-	-	-	Macro
k59_853242_1	935839.JAGJ01000008_gene1755	9.05e-15	74.3	COG1321@1|root,COG1321@2|Bacteria,2GK7P@201174|Actinobacteria,4F489@85017|Promicromonosporaceae	201174|Actinobacteria	K	FeoA	sirR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
k59_987858_1	1249627.D779_2794	7.93e-26	102.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,1WY6R@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_987858_2	572477.Alvin_2148	2.65e-62	192.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,1WYQV@135613|Chromatiales	135613|Chromatiales	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
k59_281774_1	1247963.JPHU01000019_gene3017	2.86e-80	246.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_677635_2	472759.Nhal_1062	2.41e-141	411.0	COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,1WW1A@135613|Chromatiales	135613|Chromatiales	S	PFAM Succinylglutamate desuccinylase Aspartoacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
k59_1615242_1	999611.KI421505_gene4154	2.04e-23	100.0	COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,2TRPW@28211|Alphaproteobacteria,281YC@191028|Leisingera	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_618097_1	1095767.CAHD01000015_gene915	3.91e-47	164.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,4F22I@85016|Cellulomonadaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iNJ661.Rv3152	NADHdh
k59_618097_2	44060.JODL01000034_gene3290	1.39e-17	83.2	COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria	201174|Actinobacteria	C	NADH-quinone oxidoreductase	nuoG	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_987867_1	1384057.CD33_17670	5.21e-14	77.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,4H9WW@91061|Bacilli,3IW15@400634|Lysinibacillus	91061|Bacilli	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_106816_1	765912.Thimo_1397	4.14e-73	234.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1X0HM@135613|Chromatiales	135613|Chromatiales	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_1340101_1	1126627.BAWE01000005_gene6111	2.35e-59	207.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_281786_1	768671.ThimaDRAFT_0812	2.29e-14	75.9	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,1RN7C@1236|Gammaproteobacteria,1WWZ1@135613|Chromatiales	135613|Chromatiales	S	PFAM ATPase associated with various cellular activities	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
k59_325119_1	998674.ATTE01000001_gene1834	6.38e-120	356.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,45ZP0@72273|Thiotrichales	72273|Thiotrichales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_928745_2	1286106.MPL1_06084	1.13e-25	103.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,45ZWD@72273|Thiotrichales	72273|Thiotrichales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_618107_1	1123065.ATWL01000002_gene1592	4.47e-66	206.0	COG0740@1|root,COG0740@2|Bacteria,2GKNK@201174|Actinobacteria	201174|Actinobacteria	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
k59_928746_1	1049564.TevJSym_ap00050	1.83e-105	331.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J57S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	cation transport ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
k59_1676207_1	709986.Deima_3129	4.72e-46	166.0	COG0277@1|root,COG0277@2|Bacteria,1WI90@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	FAD linked oxidases, C-terminal domain	-	-	1.1.2.4,2.5.1.26	ko:K00102,ko:K00803	ko00565,ko00620,ko01100,ko04146,map00565,map00620,map01100,map04146	-	R00197,R04311	RC00020,RC00044,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1206102_1	1268239.PALB_31100	3.51e-38	139.0	COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,2PZJ0@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	L	Belongs to the DnaA family. HdA subfamily	hda	GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113	-	ko:K10763	-	-	-	-	ko00000,ko03032	-	-	-	Bac_DnaA
k59_1505989_1	1267005.KB911264_gene3194	5.95e-88	278.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2TR86@28211|Alphaproteobacteria,3N6HP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Helicase	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_1024494_1	96561.Dole_0674	2.77e-54	183.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,42NQB@68525|delta/epsilon subdivisions,2WIWW@28221|Deltaproteobacteria,2MIPA@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM NAD-dependent glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_325124_1	1499967.BAYZ01000093_gene4034	1.19e-130	384.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
k59_106850_1	426114.THI_2666	3.81e-08	57.4	COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,1KJDZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the peptidase S11 family	pbpG	-	-	ko:K07262	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
k59_1557027_1	595460.RRSWK_03757	3.79e-68	233.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2IYDT@203682|Planctomycetes	203682|Planctomycetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_400362_1	998674.ATTE01000001_gene870	6.91e-52	172.0	COG3381@1|root,COG3381@2|Bacteria,1MWWM@1224|Proteobacteria,1S449@1236|Gammaproteobacteria,462Q6@72273|Thiotrichales	72273|Thiotrichales	S	Nitrate reductase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
k59_853273_1	543913.D521_0685	6.63e-36	129.0	COG0811@1|root,COG0811@2|Bacteria,1NMPB@1224|Proteobacteria,2VJ4U@28216|Betaproteobacteria,1KQVX@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	MotA/TolQ/ExbB proton channel family	exbB1	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_853273_2	935863.AWZR01000001_gene1559	3.58e-16	74.3	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S9R6@1236|Gammaproteobacteria,1X6GQ@135614|Xanthomonadales	135614|Xanthomonadales	U	Biopolymer	exbD1	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_736312_1	717785.HYPMC_1415	1.95e-26	108.0	COG4731@1|root,COG4731@2|Bacteria,1NHGE@1224|Proteobacteria	1224|Proteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
k59_281816_1	1249997.JHZW01000002_gene451	1.08e-14	68.2	COG3360@1|root,COG3360@2|Bacteria,4NURJ@976|Bacteroidetes,1I534@117743|Flavobacteriia,2PHT8@252356|Maribacter	976|Bacteroidetes	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
k59_1441234_1	631362.Thi970DRAFT_01542	1.36e-59	192.0	COG0119@1|root,COG0119@2|Bacteria,1MVQG@1224|Proteobacteria,1RPPW@1236|Gammaproteobacteria,1WW82@135613|Chromatiales	135613|Chromatiales	E	PFAM Pyruvate carboxyltransferase	-	-	4.1.3.39	ko:K01666	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R00750	RC00307,RC00371	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
k59_1441234_2	84531.JMTZ01000083_gene4297	1.32e-28	108.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1RPXT@1236|Gammaproteobacteria,1X6MF@135614|Xanthomonadales	135614|Xanthomonadales	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_49082_1	631362.Thi970DRAFT_04271	2.41e-67	221.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1WWMF@135613|Chromatiales	135613|Chromatiales	O	PFAM Magnesium chelatase, ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_1868367_1	452637.Oter_2944	1.06e-93	283.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
k59_1206111_1	469371.Tbis_1268	2.72e-38	136.0	COG3340@1|root,COG3340@2|Bacteria,2GZK5@201174|Actinobacteria,4DZJS@85010|Pseudonocardiales	201174|Actinobacteria	E	Peptidase family S51	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
k59_1206111_2	1894.JOER01000001_gene5258	2.86e-28	114.0	COG1233@1|root,COG1233@2|Bacteria	2|Bacteria	Q	all-trans-retinol 13,14-reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_106863_2	2340.JV46_07480	5.63e-75	239.0	28I6N@1|root,2Z89J@2|Bacteria,1MUVT@1224|Proteobacteria,1RQUY@1236|Gammaproteobacteria,1J7IW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1024499_1	1304865.JAGF01000001_gene3291	9.01e-67	223.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4F1XR@85016|Cellulomonadaceae	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
k59_1734346_1	1492922.GY26_03815	1.46e-18	91.3	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1J4PD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	GO:0003674,GO:0003824,GO:0004149,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008289,GO:0009060,GO:0009987,GO:0015980,GO:0016417,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016751,GO:0016999,GO:0017144,GO:0019752,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:0140096,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1352,iECED1_1282.ECED1_0696,iECOK1_1307.ECOK1_0726,iECS88_1305.ECS88_0752,iLF82_1304.LF82_2196,iNRG857_1313.NRG857_03235,iUMN146_1321.UM146_13990,iUTI89_1310.UTI89_C0722	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_208774_1	237368.SCABRO_03323	1.3e-34	133.0	COG3264@1|root,COG3264@2|Bacteria,2IY5W@203682|Planctomycetes	203682|Planctomycetes	M	COG3264 Small-conductance mechanosensitive channel	-	-	-	ko:K22051	-	-	-	-	ko00000,ko02000	1.A.23.1.2,1.A.23.1.3	-	-	MS_channel
k59_501728_1	768671.ThimaDRAFT_3698	3.25e-79	254.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1WWEF@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_50552_1	446471.Xcel_1359	2.07e-31	112.0	COG2146@1|root,COG2146@2|Bacteria,2IQK7@201174|Actinobacteria,4F4NT@85017|Promicromonosporaceae	201174|Actinobacteria	P	Rieske-like [2Fe-2S] domain	hcaC	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
k59_50552_2	1123065.ATWL01000001_gene551	5.3e-52	176.0	COG0719@1|root,COG0719@2|Bacteria,2GJNV@201174|Actinobacteria	201174|Actinobacteria	O	FeS assembly protein SufD	sufD	GO:0008150,GO:0009605,GO:0009607,GO:0040007,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_443085_2	2340.JV46_03430	6.16e-33	120.0	COG1192@1|root,COG1192@2|Bacteria,1MWRE@1224|Proteobacteria,1RMZN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
k59_989412_1	196162.Noca_3054	9.77e-08	56.2	COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria,4DR4Q@85009|Propionibacteriales	201174|Actinobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
k59_737239_1	1121403.AUCV01000014_gene4579	3.93e-71	238.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42N22@68525|delta/epsilon subdivisions,2WIMH@28221|Deltaproteobacteria,2MJ0S@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_1143887_1	398720.MED217_12189	1.02e-54	190.0	COG1249@1|root,COG1249@2|Bacteria,4NEMS@976|Bacteroidetes,1HZI9@117743|Flavobacteriia,2XJWR@283735|Leeuwenhoekiella	976|Bacteroidetes	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	merA	-	1.16.1.1	ko:K00520	-	-	-	-	ko00000,ko01000	-	-	-	HMA,Pyr_redox_2,Pyr_redox_dim
k59_678620_1	1304865.JAGF01000001_gene2624	6.14e-251	707.0	COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria	201174|Actinobacteria	L	helicase	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
k59_1098285_1	292563.Cyast_2005	3.82e-51	164.0	COG3651@1|root,COG3651@2|Bacteria,1G6ND@1117|Cyanobacteria	1117|Cyanobacteria	S	protein conserved in bacteria	-	-	-	ko:K09966	-	-	-	-	ko00000	-	-	-	DUF2237
k59_618977_1	983545.Glaag_0047	1.43e-52	182.0	COG2234@1|root,COG2234@2|Bacteria,1MUZ7@1224|Proteobacteria,1RS0Q@1236|Gammaproteobacteria,4653N@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_1677115_1	1047013.AQSP01000074_gene1897	6.37e-30	111.0	COG0098@1|root,COG0098@2|Bacteria,2NPGN@2323|unclassified Bacteria	2|Bacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_1677115_2	1121472.AQWN01000002_gene2057	1e-11	61.6	COG1841@1|root,COG1841@2|Bacteria,1VEG4@1239|Firmicutes,25NDI@186801|Clostridia,2639W@186807|Peptococcaceae	186801|Clostridia	J	Ribosomal protein L30	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
k59_1616160_2	314278.NB231_10778	7.78e-73	225.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1RSPA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_1869900_1	768671.ThimaDRAFT_1363	3.23e-173	496.0	COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,1RN78@1236|Gammaproteobacteria,1WWPQ@135613|Chromatiales	135613|Chromatiales	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
k59_1143902_1	1121406.JAEX01000011_gene2074	1.15e-64	212.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42MMF@68525|delta/epsilon subdivisions,2WJ1F@28221|Deltaproteobacteria,2M8PG@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
k59_108389_1	631362.Thi970DRAFT_02219	9.64e-43	154.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1WWYZ@135613|Chromatiales	135613|Chromatiales	E	PFAM Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_790272_1	34506.g3028	3.62e-22	97.8	2EGUQ@1|root,2SMPF@2759|Eukaryota,3ADXV@33154|Opisthokonta,3BZA8@33208|Metazoa,3DFB0@33213|Bilateria	33208|Metazoa	S	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4
k59_50586_1	1150469.RSPPHO_02933	1.25e-22	95.9	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,2TQZ1@28211|Alphaproteobacteria,2JTBK@204441|Rhodospirillales	204441|Rhodospirillales	S	Bacterial protein of unknown function (DUF882)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
k59_1206985_1	1276920.ADIAG_03702	1.17e-16	80.9	COG3177@1|root,COG3177@2|Bacteria,2I9ZG@201174|Actinobacteria	201174|Actinobacteria	S	Filamentation induced by cAMP protein fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic,HTH_DeoR
k59_678634_1	1118054.CAGW01000117_gene3381	1.39e-30	122.0	COG4584@1|root,COG4584@2|Bacteria,1TR5X@1239|Firmicutes,4HBD9@91061|Bacilli,26U5V@186822|Paenibacillaceae	91061|Bacilli	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1677122_2	1429046.RR21198_1559	4.29e-57	183.0	COG1846@1|root,COG1846@2|Bacteria,2GMV1@201174|Actinobacteria,4G325@85025|Nocardiaceae	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
k59_1677122_3	543632.JOJL01000015_gene8748	3.29e-38	134.0	COG2085@1|root,COG2085@2|Bacteria,2GMZ5@201174|Actinobacteria,4DBGU@85008|Micromonosporales	201174|Actinobacteria	S	NADPH-dependent F420 reductase	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
k59_1341671_1	471853.Bcav_0950	1.16e-121	365.0	COG4346@1|root,COG4346@2|Bacteria,2GITT@201174|Actinobacteria	201174|Actinobacteria	O	Dolichyl-phosphate-mannose--protein O-mannosyl transferase	pmt	GO:0000030,GO:0003674,GO:0003824,GO:0006464,GO:0006486,GO:0006493,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0019538,GO:0034645,GO:0035268,GO:0035269,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0070085,GO:0071704,GO:0097502,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	PMT,PMT_2,PMT_4TMC
k59_401903_1	768671.ThimaDRAFT_2424	9.37e-131	381.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1WVYY@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM isocitrate dehydrogenase, NADP-dependent	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,Iso_dh
k59_1036317_1	379066.GAU_0983	1.36e-18	80.1	COG2261@1|root,COG2261@2|Bacteria,1ZU62@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
k59_1687244_1	290398.Csal_1092	6.65e-08	53.5	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,1XHR6@135619|Oceanospirillales	135619|Oceanospirillales	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1687244_2	335543.Sfum_1290	1.71e-17	82.0	COG0589@1|root,COG0589@2|Bacteria,1N2H4@1224|Proteobacteria,42UE7@68525|delta/epsilon subdivisions,2WQV7@28221|Deltaproteobacteria,2MSK4@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_798142_1	765910.MARPU_09250	1.98e-114	353.0	COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,1RMNH@1236|Gammaproteobacteria,1WVVP@135613|Chromatiales	135613|Chromatiales	K	PFAM Tex-like protein N-terminal	-	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
k59_747371_1	765914.ThisiDRAFT_1666	1.89e-57	180.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,1S3Q2@1236|Gammaproteobacteria,1WYDZ@135613|Chromatiales	135613|Chromatiales	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
k59_747371_2	930169.B5T_03771	4.66e-31	114.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,1XI4I@135619|Oceanospirillales	135619|Oceanospirillales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_688603_2	1242864.D187_001772	2.89e-33	125.0	2AI7D@1|root,318MR@2|Bacteria,1Q0MU@1224|Proteobacteria,436RD@68525|delta/epsilon subdivisions,2X1E8@28221|Deltaproteobacteria,2YW7E@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1036332_1	1234364.AMSF01000015_gene3078	4.89e-55	194.0	COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,1RYUN@1236|Gammaproteobacteria,1X3FR@135614|Xanthomonadales	135614|Xanthomonadales	S	homolog of phage Mu protein gp47	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
k59_1216992_1	1121374.KB891576_gene589	6.37e-31	121.0	COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,1RPTU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_1452287_1	519989.ECTPHS_00495	2.38e-142	412.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1WWGS@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	-	-	ko:K10764	ko00270,ko00920,ko01100,map00270,map00920,map01100	-	R01288	RC00020,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_512004_1	697282.Mettu_2857	2.25e-12	66.6	COG2859@1|root,COG2859@2|Bacteria,1QU0K@1224|Proteobacteria,1RR22@1236|Gammaproteobacteria,1XGHM@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF541)	-	-	-	-	-	-	-	-	-	-	-	-	SIMPL
k59_512004_2	944435.AXAJ01000001_gene675	3.83e-23	97.4	COG3485@1|root,COG3485@2|Bacteria,1MX7W@1224|Proteobacteria,2VMB9@28216|Betaproteobacteria,1K1M2@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	PFAM intradiol ring-cleavage dioxygenase	-	-	1.13.11.37	ko:K04098	ko00361,ko00362,ko01100,ko01120,map00361,map00362,map01100,map01120	-	R03891,R04061	RC00388,RC01016	ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C,Dioxygenase_N
k59_1392087_1	105422.BBPM01000012_gene6947	4.62e-85	264.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,2NG0A@228398|Streptacidiphilus	201174|Actinobacteria	M	Glycosyl transferases group 1	mshA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_629403_1	96561.Dole_0037	3e-68	219.0	COG0457@1|root,COG0457@2|Bacteria,1RKYJ@1224|Proteobacteria,42SSS@68525|delta/epsilon subdivisions,2WPW3@28221|Deltaproteobacteria,2MNI4@213118|Desulfobacterales	28221|Deltaproteobacteria	S	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
k59_1109702_1	330214.NIDE0204	9.83e-19	85.5	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,3J13F@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
k59_1109702_2	1158756.AQXQ01000011_gene963	3.89e-63	205.0	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,1SZRM@1236|Gammaproteobacteria,1WWZE@135613|Chromatiales	135613|Chromatiales	S	Molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
k59_1109702_3	1260251.SPISAL_01690	1.77e-42	152.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1WXQX@135613|Chromatiales	135613|Chromatiales	L	DNA photolyase	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_1392088_1	1469245.JFBG01000023_gene1280	3.58e-106	323.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RN6P@1236|Gammaproteobacteria,1X2DA@135613|Chromatiales	135613|Chromatiales	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Reductase_C
k59_1392088_2	582899.Hden_2054	1.24e-10	66.2	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	poly-beta-hydroxybutyrate polymerase	phbC1	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	PHBC_N,PhaC_N
k59_1567924_2	1121921.KB898706_gene2302	7.88e-15	75.5	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,2PMN2@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	V	FtsX-like permease family	macB	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008144,GO:0008150,GO:0008559,GO:0015238,GO:0015399,GO:0015405,GO:0015893,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046618,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902495,GO:1990195,GO:1990196,GO:1990351	-	ko:K05685	ko02010,map02010	M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
k59_1452299_1	670487.Ocepr_1185	7.72e-51	179.0	COG0038@1|root,COG0569@1|root,COG0038@2|Bacteria,COG0569@2|Bacteria,1WK48@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Chloride channel protein EriC	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	TrkA_C,Voltage_CLC
k59_570474_2	1267005.KB911257_gene725	5.17e-92	277.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2TR81@28211|Alphaproteobacteria,3N63W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_688631_1	1121396.KB893083_gene436	3.07e-44	162.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2WJTT@28221|Deltaproteobacteria,2MITA@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
k59_1452308_1	335543.Sfum_1257	4.41e-62	211.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2WJ76@28221|Deltaproteobacteria,2MQVV@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_1284306_1	522306.CAP2UW1_2001	1.87e-49	166.0	COG0265@1|root,COG0265@2|Bacteria,1R40X@1224|Proteobacteria,2VMJD@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
k59_747412_1	765911.Thivi_0246	1.37e-52	182.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1WVWQ@135613|Chromatiales	135613|Chromatiales	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C
k59_747412_2	765911.Thivi_0245	1.05e-09	58.5	COG0847@1|root,COG0847@2|Bacteria,1RAF1@1224|Proteobacteria,1S9PP@1236|Gammaproteobacteria,1WWV8@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_1109726_1	768671.ThimaDRAFT_2784	3.46e-75	248.0	COG0834@1|root,COG1301@1|root,COG0834@2|Bacteria,COG1301@2|Bacteria,1P22C@1224|Proteobacteria,1RSGY@1236|Gammaproteobacteria,1WZZV@135613|Chromatiales	135613|Chromatiales	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3,SDF
k59_512034_1	265072.Mfla_0380	3.83e-30	110.0	COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,2VR62@28216|Betaproteobacteria,2KMKZ@206350|Nitrosomonadales	206350|Nitrosomonadales	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
k59_1392110_1	1158165.KB898875_gene122	6.57e-57	199.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales	135613|Chromatiales	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HTH_12,OB_RNB,RNB,S1
k59_1567946_1	1150469.RSPPHO_01498	2.77e-61	204.0	COG2710@1|root,COG2710@2|Bacteria,1MW4U@1224|Proteobacteria,2TT9B@28211|Alphaproteobacteria,2JQMW@204441|Rhodospirillales	204441|Rhodospirillales	C	Proto-chlorophyllide reductase 57 kD subunit	bchZ	-	1.3.7.14,1.3.7.15	ko:K11335	ko00860,ko01110,map00860,map01110	-	R09053,R09060	RC01008	ko00000,ko00001,ko01000	-	-	-	Oxidored_nitro,PCP_red
k59_1152969_1	1123073.KB899241_gene1957	9.61e-64	217.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1X333@135614|Xanthomonadales	135614|Xanthomonadales	I	converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA	fadE	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N,DUF1974
k59_1518416_1	1082933.MEA186_30901	1.21e-09	67.4	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_629439_2	941449.dsx2_3344	1.6e-65	212.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,2M7UU@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
k59_1284338_1	1123366.TH3_14739	6.45e-51	177.0	COG4949@1|root,COG4949@2|Bacteria,1MVI2@1224|Proteobacteria,2TSQJ@28211|Alphaproteobacteria,2JQW2@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF3422)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3422
k59_1687305_1	1121935.AQXX01000103_gene1384	2.79e-116	346.0	COG3268@1|root,COG3268@2|Bacteria,1MVI3@1224|Proteobacteria,1RSCK@1236|Gammaproteobacteria,1XJ33@135619|Oceanospirillales	135619|Oceanospirillales	S	Saccharopine dehydrogenase NADP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
k59_336719_1	1304865.JAGF01000001_gene370	6.72e-120	360.0	COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria,4F1CX@85016|Cellulomonadaceae	201174|Actinobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
k59_160420_1	395495.Lcho_0484	3.94e-46	172.0	COG2227@1|root,COG2520@1|root,COG2227@2|Bacteria,COG2520@2|Bacteria	2|Bacteria	J	tRNA (guanine(37)-N(1))-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_11,Methyltransf_21,Methyltransf_23,Methyltransf_25
k59_1745042_1	522306.CAP2UW1_1025	5.37e-101	304.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,1KQGY@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_512063_1	1121013.P873_11685	3.13e-55	188.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1X3DS@135614|Xanthomonadales	135614|Xanthomonadales	CH	Catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol	visC	-	-	ko:K03184,ko:K18800	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04987,R06146,R08768,R08775	RC00046,RC01254	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3,SE
k59_1452354_1	1424334.W822_22660	4.14e-89	273.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,3T2IU@506|Alcaligenaceae	28216|Betaproteobacteria	I	Fatty acid desaturase	ole1	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	DDE_Tnp_ISL3,FA_desaturase
k59_1452354_2	305900.GV64_05440	1.53e-21	90.9	COG2176@1|root,COG2176@2|Bacteria,1QUVW@1224|Proteobacteria,1RM8J@1236|Gammaproteobacteria,1XNJ0@135619|Oceanospirillales	135619|Oceanospirillales	L	3' exoribonuclease, RNase T-like	-	-	-	-	-	-	-	-	-	-	-	-	RNase_T
k59_1518460_1	29581.BW37_05501	8.36e-10	65.5	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,472EF@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_1284374_1	1120956.JHZK01000001_gene3368	2.8e-39	144.0	COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,2TTBA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1626203_1	396588.Tgr7_0259	4.42e-69	232.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1WXPW@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
k59_1109782_1	1304865.JAGF01000001_gene3492	4.86e-88	271.0	COG2132@1|root,COG2132@2|Bacteria,2IDXQ@201174|Actinobacteria	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_3
k59_512072_1	1265505.ATUG01000001_gene3405	1.73e-77	247.0	COG1624@1|root,COG1624@2|Bacteria,1PEQT@1224|Proteobacteria,42P5A@68525|delta/epsilon subdivisions,2WKPP@28221|Deltaproteobacteria,2MIQR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N,YbbR
k59_688692_1	1499967.BAYZ01000154_gene1466	1.25e-70	231.0	COG0699@1|root,COG0699@2|Bacteria	2|Bacteria	T	ATPase. Has a role at an early stage in the morphogenesis of the spore coat	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_864389_1	987059.RBXJA2T_17906	2.44e-06	53.1	COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,2VNC8@28216|Betaproteobacteria,1KKJ8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	Type IV pilus biogenesis stability protein PilW	pilF	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	TPR_16,TPR_17,TPR_19,TPR_2,TPR_8
k59_453372_1	880072.Desac_1216	5.55e-68	220.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJKZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Response regulator receiver	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1518495_1	1123075.AUDP01000016_gene3450	3.42e-19	92.0	COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,3WGI4@541000|Ruminococcaceae	186801|Clostridia	M	Penicillin-binding Protein	spoVD	-	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
k59_1687354_1	861299.J421_0897	4.05e-102	310.0	COG0031@1|root,COG0031@2|Bacteria,1ZTA6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EK	Domain in cystathionine beta-synthase and other proteins.	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
k59_453381_1	1232410.KI421413_gene593	1.29e-81	251.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,42NMR@68525|delta/epsilon subdivisions,2WJQR@28221|Deltaproteobacteria,43S21@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_1452390_2	1380358.JADJ01000003_gene4557	1.59e-26	107.0	COG0583@1|root,COG0583@2|Bacteria,1MWM1@1224|Proteobacteria,1RZDI@1236|Gammaproteobacteria,1XP09@135619|Oceanospirillales	135619|Oceanospirillales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1392184_1	502025.Hoch_5266	2.63e-51	174.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,42PWI@68525|delta/epsilon subdivisions,2WKFE@28221|Deltaproteobacteria,2YUTV@29|Myxococcales	28221|Deltaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.4.1.15	ko:K05396	ko00270,map00270	-	R01874	RC00382	ko00000,ko00001,ko01000	-	-	-	PALP
k59_160470_1	227377.CBU_2011	5.31e-16	74.3	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1JDWB@118969|Legionellales	118969|Legionellales	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
k59_160470_2	1122197.ATWI01000010_gene1170	1.19e-102	310.0	COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,465QJ@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	Belongs to the 'phage' integrase family. XerC subfamily	xerC	GO:0000150,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0042150,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0071139,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_160470_3	1255043.TVNIR_0082	2.05e-10	61.2	COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S9SC@1236|Gammaproteobacteria,1WY2X@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function, DUF484	-	-	-	ko:K09921	-	-	-	-	ko00000	-	-	-	DUF484
k59_453385_1	1454010.JEOE01000008_gene1851	3.42e-106	331.0	COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria	201174|Actinobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_1687365_1	713587.THITH_01340	3.37e-176	498.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1WW2B@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
k59_1626241_1	1122130.AUHN01000005_gene2388	3.14e-87	266.0	COG1272@1|root,COG1272@2|Bacteria,2GJGQ@201174|Actinobacteria	201174|Actinobacteria	S	protein hemolysin III	hlyIII	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
k59_336787_1	1304865.JAGF01000001_gene3080	1.4e-114	350.0	COG1882@1|root,COG1882@2|Bacteria,2GTTT@201174|Actinobacteria,4F0Z2@85016|Cellulomonadaceae	201174|Actinobacteria	C	Pyruvate formate lyase-like	pflB	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
k59_688719_1	1163617.SCD_n00492	1.56e-125	369.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,2VJCC@28216|Betaproteobacteria	28216|Betaproteobacteria	M	mechanosensitive ion channel	ynaI	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
k59_336789_1	391295.SSU05_1404	0.000515	47.8	COG1011@1|root,COG1011@2|Bacteria,1V3WC@1239|Firmicutes,4HHZ7@91061|Bacilli,1WSAC@1307|Streptococcus suis	91061|Bacilli	S	HAD-hyrolase-like	-	-	3.1.3.5	ko:K07025,ko:K08723	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_1452410_1	1117314.PCIT_21960	9.83e-60	203.0	COG1231@1|root,COG1231@2|Bacteria,1R5ZI@1224|Proteobacteria,1S0X5@1236|Gammaproteobacteria,2Q40A@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	E	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_1217138_1	1510531.JQJJ01000013_gene181	1.4e-87	271.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2TRN1@28211|Alphaproteobacteria,3JSH2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038,ko:K21977	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k59_1036501_1	572477.Alvin_0167	7.73e-121	367.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1WVWQ@135613|Chromatiales	135613|Chromatiales	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C
k59_1036501_2	765912.Thimo_1294	2.37e-29	115.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,1WW58@135613|Chromatiales	135613|Chromatiales	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_688755_1	391038.Bphy_5504	2.12e-62	215.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1K0FI@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Efflux pump membrane transporter	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1568093_1	1121468.AUBR01000034_gene1377	1.23e-94	294.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24E00@186801|Clostridia,42FQ1@68295|Thermoanaerobacterales	1239|Firmicutes	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_689769_2	795666.MW7_2835	2.63e-132	407.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria,1K17G@119060|Burkholderiaceae	28216|Betaproteobacteria	G	SMART alpha amylase, catalytic sub domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_513178_1	933262.AXAM01000040_gene1210	4.39e-112	334.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,42MBN@68525|delta/epsilon subdivisions,2WINT@28221|Deltaproteobacteria,2MIZ6@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_1627430_1	391595.RLO149_c015470	1.44e-163	464.0	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,2TT7X@28211|Alphaproteobacteria,2P2I1@2433|Roseobacter	28211|Alphaproteobacteria	E	ornithine cyclodeaminase, mu-crystallin homolog	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
k59_748659_1	1123392.AQWL01000003_gene290	1.16e-103	321.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,1KSG5@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Inorganic H+ pyrophosphatase	-	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1801021_1	717785.HYPMC_4628	3.17e-49	163.0	COG1846@1|root,COG1846@2|Bacteria,1RJRY@1224|Proteobacteria,2UA4D@28211|Alphaproteobacteria,3N8VY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
k59_799067_1	479433.Caci_8116	4.32e-18	87.0	COG1080@1|root,COG1080@2|Bacteria,2GIZZ@201174|Actinobacteria	201174|Actinobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_1697740_1	933262.AXAM01000002_gene566	2.78e-09	57.4	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MIZ@68525|delta/epsilon subdivisions,2WIUX@28221|Deltaproteobacteria,2MHR5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	CHASE5,HAMP,HATPase_c,HisKA,dCache_1,dCache_2
k59_1697740_2	439235.Dalk_2250	2.88e-59	187.0	COG0745@1|root,COG0745@2|Bacteria,1QW16@1224|Proteobacteria,43BR7@68525|delta/epsilon subdivisions,2X723@28221|Deltaproteobacteria,2MPIZ@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_1048475_1	1172188.KB911826_gene28	1.08e-96	296.0	COG0318@1|root,COG0318@2|Bacteria,2GN9C@201174|Actinobacteria,4FF7B@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	menE	GO:0003674,GO:0003824,GO:0008150,GO:0008756,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0040007	4.2.1.113,6.2.1.26	ko:K01911,ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030,R04031	RC00004,RC00014,RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_875712_1	1125863.JAFN01000001_gene3191	9.25e-34	124.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,42TVX@68525|delta/epsilon subdivisions,2WP4F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Lytic transglycosylase catalytic	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	DUF4124,SLT
k59_346015_1	933262.AXAM01000033_gene1642	1.95e-87	275.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MI52@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
k59_757662_1	670292.JH26_02305	0.000895	46.6	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,1JSYN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
k59_170671_1	335543.Sfum_0098	2.36e-77	253.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MQZP@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_519103_1	472759.Nhal_2423	1.11e-116	350.0	COG2170@1|root,COG2170@2|Bacteria,1MXET@1224|Proteobacteria,1RPKZ@1236|Gammaproteobacteria,1WWXK@135613|Chromatiales	135613|Chromatiales	S	glutamate--cysteine ligase	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
k59_519103_2	1123368.AUIS01000019_gene1205	9.35e-48	163.0	COG3608@1|root,COG3608@2|Bacteria,1R784@1224|Proteobacteria,1RRY6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM Succinylglutamate desuccinylase Aspartoacylase	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
k59_1697762_1	1112274.KI911560_gene1295	7.57e-50	172.0	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,2W9RF@28216|Betaproteobacteria,2KNR5@206350|Nitrosomonadales	206350|Nitrosomonadales	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_1808283_1	1267005.KB911257_gene1020	5.45e-161	459.0	COG1072@1|root,COG1072@2|Bacteria,1MV3M@1224|Proteobacteria,2TS7E@28211|Alphaproteobacteria,3N64A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Pantothenic acid kinase	coaA	-	2.7.1.33	ko:K00867	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
k59_697890_2	1122180.Lokhon_00941	3.46e-44	147.0	COG1416@1|root,COG1416@2|Bacteria,1RKXJ@1224|Proteobacteria,2UA5Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	DsrE/DsrF-like family	-	-	-	ko:K09004	-	-	-	-	ko00000	-	-	-	DrsE
k59_1161518_1	1255043.TVNIR_1307	9.26e-116	361.0	COG0457@1|root,COG0457@2|Bacteria,1QZTW@1224|Proteobacteria,1T54Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
k59_637864_1	926569.ANT_26050	2.68e-84	253.0	COG5433@1|root,COG5433@2|Bacteria,2G91M@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_578934_1	317655.Sala_2168	1.26e-81	254.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,2K3IJ@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_875757_1	933262.AXAM01000002_gene575	3.75e-71	231.0	COG0589@1|root,COG0589@2|Bacteria,1REA3@1224|Proteobacteria,42RXY@68525|delta/epsilon subdivisions,2WNM6@28221|Deltaproteobacteria,2MJWG@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1462127_1	1157634.KB912965_gene2488	2.11e-81	252.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_697924_1	1215092.PA6_001_00380	1.29e-36	135.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1YE8T@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	GO:0000166,GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b3389,iBWG_1329.BWG_3080,iECDH10B_1368.ECDH10B_3564,iECDH1ME8569_1439.ECDH1ME8569_3268,iECNA114_1301.ECNA114_3486,iEcDH1_1363.EcDH1_0324,iJO1366.b3389,iJR904.b3389,iY75_1357.Y75_RS20275	DHQ_synthase
k59_697924_2	1218075.BAYA01000022_gene5181	1.55e-19	87.4	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,1K15K@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Belongs to the dGTPase family. Type 2 subfamily	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_1048575_1	1304885.AUEY01000004_gene1016	2.7e-19	90.5	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,42MNH@68525|delta/epsilon subdivisions,2WJ4G@28221|Deltaproteobacteria,2MINK@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_461707_2	765911.Thivi_0907	6.61e-52	171.0	2CDCV@1|root,308Y1@2|Bacteria,1N74F@1224|Proteobacteria,1S130@1236|Gammaproteobacteria,1WWVV@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1227560_1	1035308.AQYY01000001_gene2295	1.06e-109	320.0	COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,247XY@186801|Clostridia,260NI@186807|Peptococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_1227560_2	1032480.MLP_11020	3.81e-10	55.8	COG0185@1|root,COG0185@2|Bacteria,2IKMS@201174|Actinobacteria,4DR2Q@85009|Propionibacteriales	201174|Actinobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_1753696_1	765914.ThisiDRAFT_0718	1.11e-86	279.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1WW5E@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_875817_1	1125863.JAFN01000001_gene2287	2.63e-31	122.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	TIGRFAM type IV pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_1808356_1	986075.CathTA2_3008	4.09e-58	195.0	COG2256@1|root,COG2256@2|Bacteria,1TPVV@1239|Firmicutes,4HAIS@91061|Bacilli	91061|Bacilli	L	ATPase related to the helicase subunit of the Holliday junction resolvase	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_637931_1	713586.KB900536_gene1804	8.13e-104	332.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1WXM6@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_1636958_1	426114.THI_2275	7.78e-17	85.9	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2W8XA@28216|Betaproteobacteria,1KPEJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_461725_1	1121861.KB899936_gene363	1.08e-07	55.5	COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,2TUCW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_461725_2	269796.Rru_A2357	1.67e-41	146.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TQKK@28211|Alphaproteobacteria,2JPDK@204441|Rhodospirillales	204441|Rhodospirillales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K12369	ko02010,map02010	M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_875822_1	1123251.ATWM01000001_gene549	1.01e-101	314.0	COG0366@1|root,COG0366@2|Bacteria,2GKT9@201174|Actinobacteria,4FEVJ@85021|Intrasporangiaceae	201174|Actinobacteria	G	Alpha amylase, catalytic domain	ams	-	2.4.1.4	ko:K05341	ko00500,map00500	-	R01823	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
k59_875824_1	478801.Ksed_15740	5.29e-47	171.0	COG1835@1|root,COG2755@1|root,COG1835@2|Bacteria,COG2755@2|Bacteria,2GKI5@201174|Actinobacteria,1ZWME@145357|Dermacoccaceae	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_1579109_1	871968.DESME_13980	5.15e-64	210.0	COG2848@1|root,COG2848@2|Bacteria,1TQG8@1239|Firmicutes,247K4@186801|Clostridia,260TZ@186807|Peptococcaceae	186801|Clostridia	S	UPF0210 protein	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
k59_637941_1	196367.JNFG01000004_gene5418	3.77e-14	72.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2VINZ@28216|Betaproteobacteria,1JZXA@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
k59_637941_2	1297569.MESS2_1590039	0.000679	42.7	COG0154@1|root,COG0154@2|Bacteria,1MU51@1224|Proteobacteria,2TS1E@28211|Alphaproteobacteria,43IDU@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_1697860_1	272568.GDI0174	6.15e-41	148.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,2TQUM@28211|Alphaproteobacteria,2JQN9@204441|Rhodospirillales	204441|Rhodospirillales	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
k59_1753726_1	1485544.JQKP01000013_gene1807	6.48e-74	233.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2VH91@28216|Betaproteobacteria,44V1D@713636|Nitrosomonadales	28216|Betaproteobacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_1753726_2	416269.APL_0929	1.98e-35	122.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,1S5XD@1236|Gammaproteobacteria,1Y8WG@135625|Pasteurellales	135625|Pasteurellales	C	Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of 2Fe2S cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system	iscA	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
k59_1697882_1	1122970.AUHC01000005_gene1833	4.03e-15	75.1	COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria,2K1IW@204457|Sphingomonadales	204457|Sphingomonadales	H	glutamate--cysteine ligase	-	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GCS2
k59_757804_1	367299.JOEE01000002_gene2407	7.72e-20	86.3	COG3682@1|root,COG3682@2|Bacteria,2IIIT@201174|Actinobacteria,4FHMJ@85021|Intrasporangiaceae	201174|Actinobacteria	K	Transcriptional regulator	blaI	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
k59_1048702_1	228410.NE0466	1.53e-41	155.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria,372CT@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Protein of unknown function (DUF3417)	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_1579165_1	550540.Fbal_3229	1.43e-14	75.1	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,CHASE4,EAL,GGDEF
k59_1637005_1	335543.Sfum_2561	9.58e-58	189.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,42NGQ@68525|delta/epsilon subdivisions,2WJRX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.25,4.1.3.34	ko:K01644,ko:K18292	ko00660,ko01100,ko02020,map00660,map01100,map02020	-	R00237,R00362	RC00067,RC00502,RC01118,RC01205	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
k59_1808418_1	78245.Xaut_3413	1.71e-44	157.0	COG4313@1|root,COG4313@2|Bacteria,1PC95@1224|Proteobacteria,2U0FJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
k59_579056_1	332101.JIBU02000045_gene3293	3.38e-14	78.2	COG4191@1|root,COG4191@2|Bacteria,1VCNJ@1239|Firmicutes	1239|Firmicutes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HATPase_c,HisKA,PAS,PAS_9,dCache_1
k59_875899_1	395961.Cyan7425_0411	8.87e-39	136.0	COG1611@1|root,COG1611@2|Bacteria,1G5P3@1117|Cyanobacteria,3KI0E@43988|Cyanothece	1117|Cyanobacteria	S	TIGRFAM TIGR00725 family protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_461785_1	870187.Thini_1961	2.31e-129	377.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,45ZYQ@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	-	-	-	-	-	-	-	-	-	-	-	-	Cys_Met_Meta_PP
k59_1402580_1	2340.JV46_17470	4.31e-92	287.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1J4EZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009987,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iE2348C_1286.E2348C_4039,iEC042_1314.EC042_4115,iECIAI39_1322.ECIAI39_4333,iECNA114_1301.ECNA114_3878,iECOK1_1307.ECOK1_4178,iECSF_1327.ECSF_3577,iECUMN_1333.ECUMN_4259,iEcSMS35_1347.EcSMS35_4097,iLF82_1304.LF82_0844,iNRG857_1313.NRG857_18570,iSFV_1184.SFV_3755,iSF_1195.SF3809,iSFxv_1172.SFxv_4151,iS_1188.S3959,iUMN146_1321.UM146_18835,iUTI89_1310.UTI89_C4281	GATase_6,SIS
k59_1462239_1	177437.HRM2_38220	7.53e-56	191.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MIZ@68525|delta/epsilon subdivisions,2WIUX@28221|Deltaproteobacteria,2MHR5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	CHASE5,HAMP,HATPase_c,HisKA,dCache_1,dCache_2
k59_1753768_1	1123236.KB899383_gene2700	3.28e-38	151.0	COG1506@1|root,COG1506@2|Bacteria,1P6E1@1224|Proteobacteria,1RPRK@1236|Gammaproteobacteria,464ZW@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Dipeptidyl peptidase IV (DPP IV) N-terminal region	dpp4	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
k59_1753770_1	396595.TK90_2136	9.55e-95	287.0	COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,1WW4G@135613|Chromatiales	135613|Chromatiales	P	PFAM CBS domain	-	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
k59_1048747_1	768671.ThimaDRAFT_2784	2.82e-70	235.0	COG0834@1|root,COG1301@1|root,COG0834@2|Bacteria,COG1301@2|Bacteria,1P22C@1224|Proteobacteria,1RSGY@1236|Gammaproteobacteria,1WZZV@135613|Chromatiales	135613|Chromatiales	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3,SDF
k59_875922_2	1205680.CAKO01000040_gene480	3.57e-51	173.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TQYV@28211|Alphaproteobacteria,2JPU4@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_639442_2	265072.Mfla_0417	1.77e-46	156.0	COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,2VRJE@28216|Betaproteobacteria,2KMUF@206350|Nitrosomonadales	206350|Nitrosomonadales	S	TPM domain	-	-	-	-	-	-	-	-	-	-	-	-	TPM_phosphatase
k59_347772_1	314264.ROS217_08259	8.61e-117	343.0	COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2TSQ3@28211|Alphaproteobacteria,46NUM@74030|Roseovarius	28211|Alphaproteobacteria	E	amino acid aldolase or racemase	dhaa	-	4.1.3.41	ko:K18425	-	-	-	-	ko00000,ko01000	-	-	-	Ala_racemase_N,D-ser_dehydrat
k59_347774_1	292415.Tbd_1501	3.19e-08	50.8	2ESIQ@1|root,33K3E@2|Bacteria,1NJ20@1224|Proteobacteria,2WCCZ@28216|Betaproteobacteria,1KTFU@119069|Hydrogenophilales	119069|Hydrogenophilales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_347774_2	870187.Thini_2823	1.3e-89	275.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,4609F@72273|Thiotrichales	72273|Thiotrichales	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_520334_1	553385.JEMF01000074_gene1336	3.16e-26	106.0	COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,1RN53@1236|Gammaproteobacteria,1XHIN@135619|Oceanospirillales	135619|Oceanospirillales	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.68	ko:K00154	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
k59_520334_2	1423144.Gal_01681	4.98e-13	67.0	COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,2U5GC@28211|Alphaproteobacteria,34FH1@302485|Phaeobacter	28211|Alphaproteobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
k59_1229453_1	395964.KE386496_gene2360	2.27e-46	156.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2TS3W@28211|Alphaproteobacteria,3NCY5@45404|Beijerinckiaceae	28211|Alphaproteobacteria	V	ATPases associated with a variety of cellular activities	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1229453_2	358681.BBR47_08890	0.000206	44.7	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,4HATE@91061|Bacilli,26RXK@186822|Paenibacillaceae	91061|Bacilli	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_759592_1	1267005.KB911257_gene762	7.74e-82	251.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TSM8@28211|Alphaproteobacteria,3N6JG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase	gyaR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_230468_1	590998.Celf_1076	5.07e-151	432.0	COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria,4F0G6@85016|Cellulomonadaceae	201174|Actinobacteria	F	PFAM IMP dehydrogenase GMP reductase	guaB3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	IMPDH
k59_759600_1	555779.Dthio_PD3188	1.14e-116	356.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,431TI@68525|delta/epsilon subdivisions,2WWAP@28221|Deltaproteobacteria,2MB98@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc,DUF4338
k59_172613_1	1123368.AUIS01000005_gene305	1.78e-138	433.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,2NCFC@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Conserved region in glutamate synthase	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1163442_1	1396141.BATP01000047_gene3919	4.19e-40	152.0	COG2208@1|root,COG3850@1|root,COG2208@2|Bacteria,COG3850@2|Bacteria,46U96@74201|Verrucomicrobia,2ITU0@203494|Verrucomicrobiae	2|Bacteria	KT	Sigma factor PP2C-like phosphatases	-	-	2.7.11.1,2.7.13.3,3.1.3.3	ko:K03407,ko:K07315,ko:K12132	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035,ko03021	-	-	-	4HB_MCP_1,GGDEF,HAMP,HATPase_c,Hpt,PAS_4,PAS_9,Pkinase,Response_reg,SpoIIE,dCache_1,sCache_3_2
k59_463418_1	511062.GU3_14560	6.99e-27	115.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1Y44T@135624|Aeromonadales	135624|Aeromonadales	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1810080_1	1294143.H681_15160	2.09e-10	57.4	COG4736@1|root,COG4736@2|Bacteria,1NGAN@1224|Proteobacteria,1SGJ2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Cbb3-type cytochrome oxidase, subunit 3	ccoQ	-	-	ko:K00407	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixQ
k59_807440_1	1380354.JIAN01000007_gene89	3.98e-67	220.0	COG2262@1|root,COG2262@2|Bacteria,2GK55@201174|Actinobacteria,4F0W2@85016|Cellulomonadaceae	201174|Actinobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_347828_1	1336249.JADW01000006_gene4081	3.01e-13	75.9	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,4B7RK@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	mdtC	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_877876_1	471853.Bcav_3822	1.16e-36	138.0	2CFFB@1|root,32S1S@2|Bacteria,2IA1Q@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_230503_1	937774.TEQUI_1050	7.4e-24	105.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,3T1EQ@506|Alcaligenaceae	28216|Betaproteobacteria	C	Catalyzes the transfer of electrons from NADH to ubiquinone	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1051230_1	697282.Mettu_0105	7.13e-51	179.0	COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,1RMUU@1236|Gammaproteobacteria,1XE0W@135618|Methylococcales	135618|Methylococcales	N	Flagellar biosynthetic protein FlhF	-	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
k59_1755266_1	243924.LT42_24275	1.15e-45	160.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,1RMQC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides	-	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
k59_1755266_2	1040986.ATYO01000017_gene817	0.000208	46.2	COG3473@1|root,COG3473@2|Bacteria,1RA2D@1224|Proteobacteria,2U5UC@28211|Alphaproteobacteria,43JH9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	Ectoine utilization protein EutA	eutA	-	5.2.1.1	ko:K01799	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Glu_race
k59_580659_2	1177179.A11A3_06495	3.5e-21	90.1	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,1RMK2@1236|Gammaproteobacteria,1XHYZ@135619|Oceanospirillales	135619|Oceanospirillales	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_807476_1	472759.Nhal_0186	1.37e-82	249.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1WW37@135613|Chromatiales	135613|Chromatiales	O	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
k59_807476_2	243233.MCA1233	3.23e-109	319.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria,1XETJ@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
k59_463510_1	378806.STAUR_4195	1.52e-60	206.0	2DGYZ@1|root,2ZXTY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1810144_1	1120953.AUBH01000002_gene1453	2.3e-18	85.9	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,464U2@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_13,Fer4_16,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_699707_2	351348.Maqu_3344	2.21e-38	143.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,4651T@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_520417_2	1307759.JOMJ01000003_gene2192	0.000725	44.7	COG0737@1|root,COG0737@2|Bacteria,1NDBC@1224|Proteobacteria,42V2W@68525|delta/epsilon subdivisions,2WS9M@28221|Deltaproteobacteria,2MFZB@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
k59_591220_2	590998.Celf_1401	8.39e-22	92.8	2DQFD@1|root,336I2@2|Bacteria,2I6ZS@201174|Actinobacteria,4F33U@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_887340_1	189753.AXAS01000102_gene5975	2.08e-60	200.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U1Z0@28211|Alphaproteobacteria,3JW1X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986,ko:K15342	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	Cas_Cas1,GIIM,RVT_1
k59_415159_1	472759.Nhal_0265	1.45e-65	218.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1WW2F@135613|Chromatiales	135613|Chromatiales	P	Chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
k59_415159_2	498211.CJA_0885	1.43e-26	105.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria,1FGQM@10|Cellvibrio	1236|Gammaproteobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iSSON_1240.SSON_4131	Semialdhyde_dh,Semialdhyde_dhC
k59_650237_1	1233950.IW22_12735	5.01e-94	290.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,4NE85@976|Bacteroidetes,1HY7H@117743|Flavobacteriia,3ZP7F@59732|Chryseobacterium	976|Bacteroidetes	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumB	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
k59_415163_1	2340.JV46_22260	5.46e-78	247.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1J4DF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iEcHS_1320.EcHS_A4240,iPC815.YPO3728	AICARFT_IMPCHas,MGS
k59_474073_1	1120956.JHZK01000042_gene3051	7.99e-57	197.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,1JQ5T@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1298398_1	106370.Francci3_3562	5.35e-94	301.0	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4ERI2@85013|Frankiales	201174|Actinobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_298145_1	649638.Trad_2275	2.37e-42	154.0	COG0364@1|root,COG0364@2|Bacteria,1WJ2H@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_1765278_1	471853.Bcav_2332	1.34e-52	187.0	COG1403@1|root,COG1403@2|Bacteria,2IMMB@201174|Actinobacteria	201174|Actinobacteria	L	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_359027_1	935839.JAGJ01000004_gene1976	2.75e-45	171.0	COG0392@1|root,COG0392@2|Bacteria,2GMAV@201174|Actinobacteria,4F3N4@85017|Promicromonosporaceae	201174|Actinobacteria	T	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
k59_591640_1	1122963.AUHB01000004_gene2953	1.02e-55	176.0	COG0494@1|root,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,2U7A4@28211|Alphaproteobacteria,36YA2@31993|Methylocystaceae	28211|Alphaproteobacteria	L	NUDIX domain	mutT	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Acetyltransf_3,NUDIX,NUDIX_4
k59_767017_1	1380354.JIAN01000008_gene3319	5.81e-17	79.3	COG0500@1|root,COG2226@2|Bacteria,2GJSF@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_1298404_1	2340.JV46_13150	1.27e-99	306.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,1J4RJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_1237404_1	1122201.AUAZ01000042_gene1270	1.12e-165	472.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,465EU@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG3547 Transposase and inactivated derivatives	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1472197_1	1370122.JHXQ01000003_gene1255	7.33e-05	51.6	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,4B88P@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	ybaL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
k59_1589124_1	1165094.RINTHH_19790	2.76e-13	70.5	COG0003@1|root,COG0003@2|Bacteria,1G1UB@1117|Cyanobacteria,1HIFP@1161|Nostocales	1117|Cyanobacteria	P	TIGRFAM arsenite-activated ATPase ArsA	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
k59_6036_1	1437824.BN940_03426	4.87e-95	311.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,3T2UZ@506|Alcaligenaceae	28216|Betaproteobacteria	C	FAD linked oxidase, C-terminal domain-containing protein 6	glpCD	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_1237414_1	1173021.ALWA01000013_gene3047	3.49e-91	296.0	COG0841@1|root,COG0841@2|Bacteria,1G0C2@1117|Cyanobacteria	1117|Cyanobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_708940_2	2754.EH55_04395	4.63e-23	98.2	COG1212@1|root,COG1212@2|Bacteria,3TA3G@508458|Synergistetes	508458|Synergistetes	H	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
k59_1001926_1	1304865.JAGF01000001_gene1614	2.92e-108	342.0	COG0493@1|root,COG4624@1|root,COG0493@2|Bacteria,COG4624@2|Bacteria,2GJ0A@201174|Actinobacteria,4F0FS@85016|Cellulomonadaceae	201174|Actinobacteria	E	TIGRFAM glutamate synthase, NADH NADPH, small subunit	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2
k59_415190_2	768671.ThimaDRAFT_2472	7.43e-73	222.0	2EQWI@1|root,33IGB@2|Bacteria,1NH87@1224|Proteobacteria,1SP5X@1236|Gammaproteobacteria,1X0X6@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_65583_1	591167.Sfla_6616	1.31e-34	124.0	COG3439@1|root,COG3439@2|Bacteria,2IKVF@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_826047_1	1395571.TMS3_0119015	5.37e-31	120.0	COG3268@1|root,COG3268@2|Bacteria,1MVI3@1224|Proteobacteria,1RS16@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Saccharopine dehydrogenase	lys	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
k59_1472227_1	1380355.JNIJ01000020_gene3830	4.31e-49	167.0	COG2740@1|root,COG2740@2|Bacteria,1RHPR@1224|Proteobacteria,2U9RY@28211|Alphaproteobacteria,3JUXE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Protein of unknown function (DUF448)	MA20_23920	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448,Ribosomal_L7Ae
k59_1648436_1	1120944.JONS01000001_gene2015	3.13e-09	63.5	COG1408@1|root,COG1408@2|Bacteria,2GM8M@201174|Actinobacteria,4D4CT@85005|Actinomycetales	201174|Actinobacteria	S	PFAM Metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
k59_1826586_1	631362.Thi970DRAFT_01556	3.01e-54	182.0	COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,1WW1A@135613|Chromatiales	135613|Chromatiales	S	PFAM Succinylglutamate desuccinylase Aspartoacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
k59_415203_1	879212.DespoDRAFT_03206	7.87e-99	310.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MHRD@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1530604_1	768671.ThimaDRAFT_2364	1.16e-84	272.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
k59_1237443_1	387093.SUN_1729	1.22e-67	208.0	COG1943@1|root,COG1943@2|Bacteria,1RF1K@1224|Proteobacteria,42VRT@68525|delta/epsilon subdivisions,2YQZ0@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	L	COGs COG1943 Transposase and inactivated derivatives	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_887410_1	269799.Gmet_3395	1.2e-102	311.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2WJQQ@28221|Deltaproteobacteria,43TF1@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	belongs to the aldehyde dehydrogenase family	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3395	Aldedh
k59_1706932_1	1031711.RSPO_c00175	4e-78	250.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2VHN5@28216|Betaproteobacteria,1K180@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_887412_1	2340.JV46_03650	1.36e-85	263.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RR4I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_474127_1	1121405.dsmv_3583	8.39e-117	337.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,42N5W@68525|delta/epsilon subdivisions,2WIU3@28221|Deltaproteobacteria,2MIQ4@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_1826605_3	420324.KI912010_gene8984	3.5e-39	145.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2TVFI@28211|Alphaproteobacteria,1JXMK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Site-specific recombinase, DNA invertase Pin	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,Recombinase,Resolvase,Zn_ribbon_recom
k59_415214_1	1304865.JAGF01000001_gene1581	3.4e-111	326.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,4F1V0@85016|Cellulomonadaceae	201174|Actinobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1530610_1	756067.MicvaDRAFT_0595	4.53e-43	171.0	COG0517@1|root,COG2202@1|root,COG2905@1|root,COG5000@1|root,COG5001@1|root,COG0517@2|Bacteria,COG2202@2|Bacteria,COG2905@2|Bacteria,COG5000@2|Bacteria,COG5001@2|Bacteria,1G0BS@1117|Cyanobacteria,1H9V4@1150|Oscillatoriales	1117|Cyanobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_1706938_1	880072.Desac_0499	5.8e-121	358.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,42NP0@68525|delta/epsilon subdivisions,2WVG4@28221|Deltaproteobacteria,2MRQ6@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_887420_1	743719.PaelaDRAFT_0553	5.56e-06	47.8	COG0420@1|root,COG0420@2|Bacteria,1TWMI@1239|Firmicutes,4HCA0@91061|Bacilli,26S26@186822|Paenibacillaceae	91061|Bacilli	L	DNA repair exonuclease	yhaO	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2
k59_65623_1	1279017.AQYJ01000022_gene2608	4.46e-08	57.0	COG2304@1|root,COG2304@2|Bacteria,1QBPM@1224|Proteobacteria,1RQIU@1236|Gammaproteobacteria,466ZS@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Secreted protein, containing von Willebrand factor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_359097_1	1123355.JHYO01000029_gene3742	0.0	1033.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2TQYD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	napA	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0048037,GO:0051536,GO:0051540,GO:0055114	-	ko:K00372,ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530,M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_767056_1	446466.Cfla_1371	6.84e-129	391.0	COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,4F12Z@85016|Cellulomonadaceae	201174|Actinobacteria	E	PFAM Peptidase M1 membrane alanine aminopeptidase	pepN	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
k59_240054_1	717785.HYPMC_2597	6.38e-70	213.0	COG0720@1|root,COG0720@2|Bacteria,1RI8E@1224|Proteobacteria,2U8NH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	synthase	-	-	-	-	-	-	-	-	-	-	-	-	PTPS
k59_240054_2	1211115.ALIQ01000215_gene2362	2.14e-31	120.0	COG0438@1|root,COG0438@2|Bacteria,1PENP@1224|Proteobacteria,2V82R@28211|Alphaproteobacteria,3NBUI@45404|Beijerinckiaceae	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_1765333_1	2340.JV46_11210	1.32e-31	119.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1J5F5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_1765333_2	511062.GU3_06105	2.69e-29	112.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1Y473@135624|Aeromonadales	135624|Aeromonadales	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_1178600_1	765913.ThidrDRAFT_0491	1.62e-06	50.4	COG2703@1|root,COG2703@2|Bacteria,1PGB2@1224|Proteobacteria,1S66U@1236|Gammaproteobacteria,1WYK7@135613|Chromatiales	135613|Chromatiales	P	TIGRFAM hemerythrin-like metal-binding	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
k59_1648469_1	290399.Arth_3962	2.35e-111	329.0	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria,1W8IY@1268|Micrococcaceae	201174|Actinobacteria	E	alcohol dehydrogenase	adh	-	-	ko:K18369	ko00640,map00640	-	R10703	RC00545	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
k59_65635_1	1231241.Mc24_09099	3.36e-50	181.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,2GCR9@200918|Thermotogae	200918|Thermotogae	I	PFAM ATPase, BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
k59_1826622_1	1123279.ATUS01000001_gene1972	8.92e-55	182.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1J4TG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the CarA family	carA	GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1950,iUTI89_1310.UTI89_C0036,ic_1306.c0040	CPSase_sm_chain,GATase
k59_1826622_2	1249627.D779_2923	1.03e-110	325.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1WXGX@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
k59_240069_1	765913.ThidrDRAFT_1050	4.54e-60	200.0	COG0659@1|root,COG0664@1|root,COG0659@2|Bacteria,COG0664@2|Bacteria,1MVWV@1224|Proteobacteria	1224|Proteobacteria	P	COG0659 Sulfate permease and related transporters (MFS superfamily	bicA	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp,cNMP_binding
k59_1765344_1	1146883.BLASA_2024	3.12e-11	66.2	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria	201174|Actinobacteria	NU	Type ii secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
k59_1765344_2	1292020.H483_0115365	1.74e-52	175.0	COG4965@1|root,COG4965@2|Bacteria,2H577@201174|Actinobacteria	201174|Actinobacteria	U	Type ii secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF,VWA_2
k59_1237477_1	1121374.KB891587_gene3034	3.67e-66	218.0	COG3437@1|root,COG4191@1|root,COG3437@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RR5W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Phosphonate-bd,Response_reg
k59_1472283_1	1095767.CAHD01000213_gene637	2.23e-224	664.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2GN09@201174|Actinobacteria,4F12G@85016|Cellulomonadaceae	201174|Actinobacteria	E	glutamate synthase alpha subunit domain protein	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_359126_1	526222.Desal_3047	2.04e-178	536.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MG2T@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_650322_1	519989.ECTPHS_03076	4.13e-97	310.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1WX68@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1826642_1	243231.GSU0453	1.04e-23	99.8	COG0775@1|root,COG0775@2|Bacteria,1NDXU@1224|Proteobacteria,42TU4@68525|delta/epsilon subdivisions,2WQX3@28221|Deltaproteobacteria,43U5Q@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnB	-	3.2.2.26	ko:K11783	ko00130,ko01110,map00130,map01110	-	R08587	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
k59_887455_1	713586.KB900536_gene2946	1.33e-20	87.0	COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,1S8VU@1236|Gammaproteobacteria,1WYI6@135613|Chromatiales	135613|Chromatiales	J	Belongs to the HSP15 family	-	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
k59_887455_2	1283300.ATXB01000001_gene1470	1.45e-30	111.0	COG1051@1|root,COG1051@2|Bacteria,1MWNH@1224|Proteobacteria,1S56W@1236|Gammaproteobacteria,1XF4J@135618|Methylococcales	135618|Methylococcales	F	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
k59_1589191_1	1469613.JT55_13990	9.66e-29	117.0	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2TRA7@28211|Alphaproteobacteria,3FCYE@34008|Rhodovulum	28211|Alphaproteobacteria	C	FAD binding domain	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1354724_1	177437.HRM2_38950	3.58e-83	269.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MPY1@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
k59_887461_1	472759.Nhal_0023	3.89e-80	254.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1WVY6@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
k59_6165_1	351348.Maqu_0073	7.49e-22	94.4	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RR1B@1236|Gammaproteobacteria,46421@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	ATP-dependent helicase HrpB	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_6165_2	1341679.P253_01492	6.86e-13	73.6	COG3904@1|root,COG3904@2|Bacteria,1N4W6@1224|Proteobacteria,1S5D1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	periplasmic protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1119369_1	742159.HMPREF0004_0196	1.38e-07	62.4	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria,3T8VD@506|Alcaligenaceae	28216|Betaproteobacteria	M	Mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
k59_1473079_1	1121918.ARWE01000001_gene3562	1.45e-75	234.0	COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria	1224|Proteobacteria	Q	Methyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31,Ubie_methyltran
k59_1473079_2	472759.Nhal_2917	3.98e-25	95.9	arCOG11477@1|root,32TJG@2|Bacteria,1MYXX@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
k59_1593113_1	717785.HYPMC_1647	8.36e-52	168.0	COG1278@1|root,COG1278@2|Bacteria,1RAUE@1224|Proteobacteria,2U0S7@28211|Alphaproteobacteria,3N6P7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Cold-shock	cspB	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_1478344_1	1000565.METUNv1_01604	3.69e-90	280.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KVV3@206389|Rhodocyclales	206389|Rhodocyclales	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_185124_1	1163408.UU9_10652	3.1e-78	258.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1X47W@135614|Xanthomonadales	135614|Xanthomonadales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_830577_1	644282.Deba_2892	1.16e-27	117.0	COG0457@1|root,COG0501@1|root,COG0457@2|Bacteria,COG0501@2|Bacteria,1R5A7@1224|Proteobacteria,42MP6@68525|delta/epsilon subdivisions,2WK92@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	peptidase M48, Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_11,TPR_17
k59_478325_2	471853.Bcav_3070	7.84e-53	172.0	COG0454@1|root,COG0456@2|Bacteria,2IM9R@201174|Actinobacteria	201174|Actinobacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
k59_71539_1	177437.HRM2_02420	1.35e-58	190.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria,2MJ7C@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_893247_1	1502851.FG93_02488	3.41e-51	179.0	COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,2TS69@28211|Alphaproteobacteria,3JS5W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	chvG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K14980	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Sensor_TM1,Stimulus_sens_1
k59_14371_2	666685.R2APBS1_3830	3.64e-85	276.0	COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,1X3Z7@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyltransferase	aas	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase,MFS_1
k59_248106_1	247156.NFA_18600	1.26e-25	107.0	COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria,4FU8B@85025|Nocardiaceae	201174|Actinobacteria	E	Belongs to the TrpC family	trpC	GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
k59_248106_2	520709.F985_00586	1.46e-08	55.5	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,1S41P@1236|Gammaproteobacteria,3NIWQ@468|Moraxellaceae	1236|Gammaproteobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
k59_1067836_1	1158756.AQXQ01000005_gene221	4.51e-102	316.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1WW4U@135613|Chromatiales	135613|Chromatiales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_1652971_1	247490.KSU1_D0636	1.28e-46	167.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,Methyltransf_11,Methyltransf_23,Methyltransf_25
k59_595611_1	1056820.KB900632_gene2210	5.74e-81	255.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,1RNXE@1236|Gammaproteobacteria,2PMN4@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	K	Segregation and condensation complex subunit ScpB	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
k59_14384_1	1121920.AUAU01000011_gene175	2.17e-31	120.0	COG0345@1|root,COG0345@2|Bacteria,3Y41B@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
k59_1418191_1	1336208.JADY01000038_gene33	0.000294	42.7	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2UFRX@28211|Alphaproteobacteria,2JU4S@204441|Rhodospirillales	204441|Rhodospirillales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_1418191_2	1123073.KB899241_gene3192	4.43e-74	234.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1X4QV@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_126431_2	292415.Tbd_0023	2.53e-27	103.0	COG4783@1|root,COG4783@2|Bacteria,1N76P@1224|Proteobacteria,2VVKK@28216|Betaproteobacteria,1KT9R@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_952265_1	926560.KE387026_gene4252	1.37e-83	254.0	COG2508@1|root,COG2508@2|Bacteria,1WM8X@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	QT	Bacterial regulatory protein, Fis family	-	-	-	ko:K09684	-	-	-	-	ko00000,ko03000	-	-	-	HTH_30,PucR
k59_14400_1	1077972.ARGLB_078_00050	2.38e-11	60.8	COG3847@1|root,COG3847@2|Bacteria,2GX2Y@201174|Actinobacteria	201174|Actinobacteria	U	PFAM Flp Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
k59_14400_2	1150398.JIBJ01000005_gene3343	4.16e-10	60.1	COG4961@1|root,COG4961@2|Bacteria	2|Bacteria	U	PFAM TadE family protein	-	-	-	ko:K12513	-	-	-	-	ko00000,ko02044	-	-	-	TadE
k59_770558_1	1444711.CCJF01000005_gene461	1.33e-61	210.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,2JFEX@204428|Chlamydiae	204428|Chlamydiae	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_1067851_1	404589.Anae109_4120	1.04e-71	227.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42N7U@68525|delta/epsilon subdivisions,2WJ81@28221|Deltaproteobacteria,2Z0MS@29|Myxococcales	28221|Deltaproteobacteria	C	Radical SAM superfamily	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_1067851_2	330214.NIDE3807	1.33e-34	125.0	COG0396@1|root,COG0396@2|Bacteria,3J19D@40117|Nitrospirae	40117|Nitrospirae	O	ABC transporter	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
k59_537192_1	1230476.C207_00264	2.27e-130	378.0	COG0111@1|root,COG0111@2|Bacteria,1MW0R@1224|Proteobacteria,2TWC9@28211|Alphaproteobacteria,3JVP3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_365045_1	762982.HMPREF9442_00419	2.47e-99	318.0	COG4733@1|root,COG4733@2|Bacteria,4PMTT@976|Bacteroidetes,2G0FY@200643|Bacteroidia	976|Bacteroidetes	U	Alginate lyase	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase
k59_71582_1	1165841.SULAR_00240	2.07e-67	211.0	COG0500@1|root,COG0500@2|Bacteria,1MVSK@1224|Proteobacteria,42N9H@68525|delta/epsilon subdivisions,2YMGK@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs	cmoB	-	-	ko:K15257	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_9
k59_1478394_1	913325.N799_06645	6.51e-32	122.0	COG0031@1|root,COG0517@1|root,COG0031@2|Bacteria,COG0517@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1X4GC@135614|Xanthomonadales	135614|Xanthomonadales	E	Cystathionine beta-synthase	cysB	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
k59_1478394_2	672.VV93_v1c08630	2.19e-18	84.3	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1XTR8@135623|Vibrionales	135623|Vibrionales	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	Methyltransf_31
k59_248150_1	1304883.KI912532_gene2886	3.48e-27	110.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VH6U@28216|Betaproteobacteria,2KZSZ@206389|Rhodocyclales	206389|Rhodocyclales	L	PFAM integrase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,rve
k59_126444_1	446462.Amir_6482	1.35e-12	74.3	COG0515@1|root,COG0515@2|Bacteria,2GIW5@201174|Actinobacteria,4E1N3@85010|Pseudonocardiales	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,Septum_form
k59_1304501_1	471853.Bcav_1748	2.67e-157	451.0	COG1420@1|root,COG1420@2|Bacteria,2GKF5@201174|Actinobacteria	201174|Actinobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HTH_DeoR,HrcA
k59_1478396_1	521393.JH806632_gene44	1.01e-65	223.0	COG0514@1|root,COG1040@1|root,COG0514@2|Bacteria,COG1040@2|Bacteria,2GJSS@201174|Actinobacteria,4D34E@85005|Actinomycetales	201174|Actinobacteria	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
k59_893291_1	648757.Rvan_2907	2.88e-126	375.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2TQSW@28211|Alphaproteobacteria,3N6JD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_419518_2	1298863.AUEP01000010_gene4490	1.54e-37	140.0	2B482@1|root,32B63@2|Bacteria,2HYG5@201174|Actinobacteria,4DUMR@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_14423_1	1035308.AQYY01000001_gene3017	2.74e-96	290.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,260XK@186807|Peptococcaceae	186801|Clostridia	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.83,1.1.1.85,1.1.1.93,4.1.1.73	ko:K00052,ko:K07246	ko00290,ko00630,ko00650,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00630,map00650,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00215,R00994,R01751,R02545,R04426,R06180,R10052	RC00084,RC00105,RC00417,RC00594,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_71592_1	768706.Desor_3622	1.24e-20	91.3	COG0777@1|root,COG0777@2|Bacteria,1TP4U@1239|Firmicutes,248QK@186801|Clostridia,26062@186807|Peptococcaceae	186801|Clostridia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_248163_1	309807.SRU_1930	2.6e-57	192.0	COG0297@1|root,COG0297@2|Bacteria,4PKP8@976|Bacteroidetes,1FJT6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Starch synthase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glyco_transf_5,Glycos_transf_1
k59_952291_1	377629.TERTU_0105	5.73e-147	429.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,2PN3I@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	S	Sodium:solute symporter family	actP	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_1418919_2	63737.Npun_R5724	2.87e-147	427.0	COG3033@1|root,COG3033@2|Bacteria,1G33V@1117|Cyanobacteria,1HQEM@1161|Nostocales	1117|Cyanobacteria	E	Beta-eliminating lyase	tpl	-	4.1.99.2	ko:K01668	ko00350,map00350	-	R00728	RC00355,RC00364	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_537846_1	1123368.AUIS01000029_gene1289	3.63e-182	524.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,2NBWK@225057|Acidithiobacillales	1236|Gammaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1593787_1	1122135.KB893151_gene3113	2.22e-47	171.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2U0EN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_15835_2	713586.KB900536_gene1010	7.91e-98	297.0	COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,1RZQ2@1236|Gammaproteobacteria,1WXSM@135613|Chromatiales	135613|Chromatiales	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_15840_1	446466.Cfla_3317	2.78e-41	153.0	COG1112@1|root,COG1112@2|Bacteria,2H3MV@201174|Actinobacteria	201174|Actinobacteria	L	Type III restriction enzyme res subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,NERD,UvrD_C_2
k59_1006063_1	998088.B565_0300	9.52e-78	242.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1Y42E@135624|Aeromonadales	135624|Aeromonadales	M	Arabinose 5-phosphate isomerase	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
k59_1006063_2	1111454.HMPREF1250_0722	9.42e-07	49.3	COG1778@1|root,COG1778@2|Bacteria,1V5JJ@1239|Firmicutes,4H4ID@909932|Negativicutes	909932|Negativicutes	S	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family	kdsC	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
k59_72565_1	56780.SYN_03249	1.55e-61	202.0	COG3464@1|root,COG3464@2|Bacteria,1N2V1@1224|Proteobacteria,42TEG@68525|delta/epsilon subdivisions,2WPXW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Helix-turn-helix domain of transposase family ISL3	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_953303_1	1146883.BLASA_2168	0.000116	41.6	COG2161@1|root,COG2161@2|Bacteria,2GRC8@201174|Actinobacteria	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
k59_953303_2	590998.Celf_3144	6.98e-22	95.1	COG0507@1|root,COG0507@2|Bacteria,2GJRK@201174|Actinobacteria	201174|Actinobacteria	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_30,TrwC
k59_1833662_1	765913.ThidrDRAFT_3979	5.48e-63	204.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RPM1@1236|Gammaproteobacteria,1WW4Q@135613|Chromatiales	135613|Chromatiales	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_831323_1	1449068.JMLQ01000009_gene3661	8.38e-29	109.0	COG1514@1|root,COG1514@2|Bacteria,2IFPP@201174|Actinobacteria,4G2MC@85025|Nocardiaceae	201174|Actinobacteria	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
k59_249472_1	1123508.JH636443_gene5018	4.16e-21	89.4	COG3324@1|root,COG3324@2|Bacteria,2J3W8@203682|Planctomycetes	203682|Planctomycetes	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
k59_249472_2	1713.JOFV01000003_gene1672	2.09e-25	102.0	COG0258@1|root,COG0258@2|Bacteria,2GKTZ@201174|Actinobacteria,4F0ZP@85016|Cellulomonadaceae	201174|Actinobacteria	L	PFAM 5'-3' exonuclease, N-terminal resolvase-like domain	polA_1	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
k59_1006070_1	1121351.AUAP01000001_gene655	2.44e-13	77.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2VHBB@28216|Betaproteobacteria,2KPUQ@206351|Neisseriales	206351|Neisseriales	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_1123494_1	765910.MARPU_00280	1.68e-61	202.0	COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,1RMAV@1236|Gammaproteobacteria,1WZAK@135613|Chromatiales	135613|Chromatiales	U	Involved in arsenical resistance. Thought to form the channel of an arsenite pump	arsB	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB
k59_1123494_2	765910.MARPU_00275	1.75e-08	55.5	2FHYC@1|root,349RC@2|Bacteria,1P31R@1224|Proteobacteria,1SRZR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_302933_2	1437882.AZRU01000046_gene5131	1.89e-08	57.4	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,1RS3I@1236|Gammaproteobacteria,1YFBW@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	yhiI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_185949_1	435908.IDSA_08400	2.09e-25	109.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,2QEZB@267893|Idiomarinaceae	1236|Gammaproteobacteria	E	Peptidase family M3	prlC	GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006465,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0034645,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051604,GO:0070011,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901576	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_714234_1	292415.Tbd_2810	1.02e-23	103.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VH4J@28216|Betaproteobacteria,1KRGP@119069|Hydrogenophilales	119069|Hydrogenophilales	S	ABC transporter C-terminal domain	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_1305522_1	197221.22294709	1.11e-29	117.0	COG1215@1|root,COG1215@2|Bacteria,1G1IP@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glyco_tranf_2_3,Glycos_transf_2
k59_537890_1	314278.NB231_05651	8.63e-36	140.0	COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,1WX80@135613|Chromatiales	135613|Chromatiales	M	PFAM LppC	-	-	-	ko:K07121	-	-	-	-	ko00000	-	-	-	LppC
k59_537890_2	1175306.GWL_40320	5.33e-08	51.6	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,2VU20@28216|Betaproteobacteria,474NW@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
k59_655596_1	243924.LT42_18565	8.58e-77	241.0	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,1RMBF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	heptosyltransferase	rfaF	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	iECH74115_1262.ECH74115_4993,iECSP_1301.ECSP_4617,iECs_1301.ECs4498,iG2583_1286.G2583_4359,iZ_1308.Z5047	Glyco_transf_9
k59_366124_1	1318628.MARLIPOL_00583	1.95e-33	134.0	COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,464YJ@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	TPR_1,TPR_2,VWA_2
k59_1418967_1	1121875.KB907546_gene2203	1.65e-18	84.0	COG2367@1|root,COG2367@2|Bacteria,4NE3C@976|Bacteroidetes,1HZYJ@117743|Flavobacteriia	976|Bacteroidetes	V	beta-lactamase	per1	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
k59_1418967_2	1038867.AXAY01000041_gene5542	8.86e-30	117.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,3JSY1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1305537_1	765911.Thivi_0017	2.08e-70	223.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,1RNH3@1236|Gammaproteobacteria,1WWNS@135613|Chromatiales	135613|Chromatiales	I	TIGRFAM malonyl CoA-acyl carrier protein transacylase	-	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
k59_894348_1	67373.JOBF01000012_gene4007	1.02e-63	207.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1183985_1	331678.Cphamn1_1233	1.66e-72	233.0	COG0581@1|root,COG0581@2|Bacteria,1FE3G@1090|Chlorobi	1090|Chlorobi	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstA	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
k59_1479466_1	1328313.DS2_15924	2.66e-21	98.6	COG5001@1|root,COG5001@2|Bacteria,1QV5H@1224|Proteobacteria,1T299@1236|Gammaproteobacteria,467MN@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,LapD_MoxY_N
k59_1244442_2	1429046.RR21198_5965	7.18e-63	207.0	COG3385@1|root,COG3385@2|Bacteria,2H68X@201174|Actinobacteria,4FXGX@85025|Nocardiaceae	201174|Actinobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_15947_1	1266909.AUAG01000025_gene1847	6.52e-83	250.0	COG4636@1|root,COG4636@2|Bacteria,1RCFH@1224|Proteobacteria,1S3NE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
k59_15953_1	1283283.ATXA01000007_gene3861	1.53e-14	75.1	COG1226@1|root,COG1226@2|Bacteria,2GJS6@201174|Actinobacteria,4EX0Y@85013|Frankiales	201174|Actinobacteria	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_C,TrkA_N
k59_1068895_1	580332.Slit_0139	1.01e-109	339.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,44VBN@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_1833730_1	391735.Veis_3120	3.13e-12	65.5	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2VH5M@28216|Betaproteobacteria,4AB5K@80864|Comamonadaceae	28216|Betaproteobacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_1833730_2	768671.ThimaDRAFT_0249	1.39e-108	325.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,1WWZH@135613|Chromatiales	135613|Chromatiales	EH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_714256_1	767434.Fraau_2996	4.28e-47	168.0	COG0477@1|root,COG0477@2|Bacteria,1R9KU@1224|Proteobacteria,1T4K2@1236|Gammaproteobacteria,1XDAH@135614|Xanthomonadales	135614|Xanthomonadales	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_23539_1	83406.HDN1F_05210	8.04e-66	209.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1J5E4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0004042,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016407,GO:0016410,GO:0016597,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0033554,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.7.2.8	ko:K00930,ko:K22478	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00259,R02649	RC00002,RC00004,RC00043,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_2508,iB21_1397.B21_03793,iEC55989_1330.EC55989_4441,iECB_1328.ECB_03844,iECDH10B_1368.ECDH10B_4147,iECDH1ME8569_1439.ECDH1ME8569_3827,iECD_1391.ECD_03844,iECH74115_1262.ECH74115_5419,iECIAI1_1343.ECIAI1_4167,iECO103_1326.ECO103_4715,iECOK1_1307.ECOK1_4431,iECS88_1305.ECS88_4414,iECSE_1348.ECSE_4252,iETEC_1333.ETEC_4227,iEcE24377_1341.EcE24377A_4498,iEcHS_1320.EcHS_A4193,iEcolC_1368.EcolC_4057,iSbBS512_1146.SbBS512_E4445,iUMN146_1321.UM146_20050,iUMNK88_1353.UMNK88_4797,iUTI89_1310.UTI89_C4550,iY75_1357.Y75_RS17255	AA_kinase,NAT
k59_1840571_1	555779.Dthio_PD2497	2.85e-32	117.0	COG1528@1|root,COG1528@2|Bacteria,1R9ZC@1224|Proteobacteria,42S74@68525|delta/epsilon subdivisions,2WNFJ@28221|Deltaproteobacteria,2MBEX@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Iron-storage protein	ftn	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
k59_1840571_2	243232.MJ_0737	1.33e-10	56.6	COG1773@1|root,arCOG05047@2157|Archaea	2157|Archaea	C	iron ion binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_836335_1	765911.Thivi_1389	1.74e-12	71.2	COG3637@1|root,COG3637@2|Bacteria,1QYQM@1224|Proteobacteria,1T59D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1716300_1	314264.ROS217_20117	3.95e-41	147.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2TS2H@28211|Alphaproteobacteria,46QJ0@74030|Roseovarius	28211|Alphaproteobacteria	M	COG1560 Lauroyl myristoyl acyltransferase	msbB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_1312360_1	1120970.AUBZ01000027_gene1531	4.75e-52	173.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,4654U@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide	uppS	GO:0000270,GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006066,GO:0006629,GO:0006720,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	iECBD_1354.ECBD_3445,iECOK1_1307.ECOK1_0175,iECSE_1348.ECSE_0173,iECW_1372.ECW_m0170,iEKO11_1354.EKO11_3744,iEcDH1_1363.EcDH1_3429,iEcE24377_1341.EcE24377A_0178,iEcHS_1320.EcHS_A0176,iNRG857_1313.NRG857_00890,iSFV_1184.SFV_0157,iUMN146_1321.UM146_23675,iUMNK88_1353.UMNK88_178,iWFL_1372.ECW_m0170,iY75_1357.Y75_RS00880	Prenyltransf
k59_960190_1	1121413.JMKT01000009_gene1951	8.64e-55	182.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,42R8Z@68525|delta/epsilon subdivisions,2WMXX@28221|Deltaproteobacteria,2MAE4@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin,cNMP_binding
k59_1598716_1	68260.JOAY01000064_gene798	1.18e-25	103.0	COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria	201174|Actinobacteria	F	IMP dehydrogenase	guaB3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	IMPDH
k59_1598716_2	1170318.PALO_02130	1.32e-33	118.0	COG1605@1|root,COG1605@2|Bacteria,2IQ46@201174|Actinobacteria,4DRPY@85009|Propionibacteriales	201174|Actinobacteria	E	Chorismate mutase type II	tyrA	-	5.4.99.5	ko:K04092	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2
k59_719219_1	1121405.dsmv_2974	1.22e-110	347.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2X5GV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EF	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_542751_1	304371.MCP_0988	1.8e-131	375.0	arCOG01638@1|root,arCOG01638@2157|Archaea,2Y3ZV@28890|Euryarchaeota,2NB2D@224756|Methanomicrobia	224756|Methanomicrobia	Q	Methyltransferase type	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
k59_1598725_1	529818.AMSG_07273T0	5.36e-10	60.8	COG2226@1|root,KOG1540@2759|Eukaryota	2759|Eukaryota	H	2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity	UBIE	-	-	-	-	-	-	-	-	-	-	-	Ubie_methyltran
k59_775218_1	713586.KB900536_gene315	5.43e-57	185.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,1RMAE@1236|Gammaproteobacteria,1WWTZ@135613|Chromatiales	135613|Chromatiales	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
k59_1840612_1	637389.Acaty_c1993	1.77e-21	92.8	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,2NC51@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	-	-	ko:K10764	ko00270,ko00920,ko01100,map00270,map00920,map01100	-	R01288	RC00020,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1840612_2	1123377.AUIV01000020_gene2449	5.88e-43	149.0	COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,1RNGA@1236|Gammaproteobacteria,1X4VY@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF455
k59_1540391_1	644801.Psest_2926	1.45e-122	364.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,1RQI4@1236|Gammaproteobacteria,1Z1JK@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	DinB superfamily	egtB	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
k59_836360_1	1122604.JONR01000010_gene3920	1.46e-73	228.0	COG3186@1|root,COG3186@2|Bacteria,1MU29@1224|Proteobacteria,1RQBJ@1236|Gammaproteobacteria,1X3NW@135614|Xanthomonadales	135614|Xanthomonadales	E	Phenylalanine-4-hydroxylase	phhA	-	1.14.16.1	ko:K00500	ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230	-	R01795,R07211	RC00490	ko00000,ko00001,ko01000	-	-	-	Biopterin_H
k59_1189094_1	1035308.AQYY01000001_gene2470	1.12e-93	289.0	COG0464@1|root,COG0464@2|Bacteria,1TPQZ@1239|Firmicutes,24BQK@186801|Clostridia,2653P@186807|Peptococcaceae	186801|Clostridia	O	Holliday junction DNA helicase ruvB N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_23584_2	864702.OsccyDRAFT_2201	3.71e-58	197.0	COG0119@1|root,COG0119@2|Bacteria,1G0JT@1117|Cyanobacteria,1H77Z@1150|Oscillatoriales	1117|Cyanobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1840620_1	1517681.HW45_06100	9.69e-35	133.0	COG4775@1|root,COG4775@2|Bacteria,1QVN6@1224|Proteobacteria,1T2FG@1236|Gammaproteobacteria,1Y3BX@135623|Vibrionales	135623|Vibrionales	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
k59_1658928_1	2074.JNYD01000064_gene6755	9.15e-151	431.0	COG3039@1|root,COG3039@2|Bacteria,2GJQM@201174|Actinobacteria,4DZWS@85010|Pseudonocardiales	201174|Actinobacteria	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_3
k59_660661_1	398767.Glov_1392	1.7e-62	216.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43U04@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1312405_1	305700.B447_07137	1.83e-131	390.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2VJEQ@28216|Betaproteobacteria,2KUQ3@206389|Rhodocyclales	206389|Rhodocyclales	G	BT1 family	-	-	-	-	-	-	-	-	-	-	-	-	BT1
k59_901268_1	941449.dsx2_1623	4.09e-119	355.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42Q49@68525|delta/epsilon subdivisions,2X5E9@28221|Deltaproteobacteria,2M8TQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1424075_1	1267005.KB911256_gene1762	3.83e-84	262.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2TRT0@28211|Alphaproteobacteria,3N64U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_257221_2	1713.JOFV01000018_gene220	7.24e-69	222.0	COG0382@1|root,COG0382@2|Bacteria,2GJT3@201174|Actinobacteria,4F157@85016|Cellulomonadaceae	201174|Actinobacteria	H	UbiA prenyltransferase family	ubiA	-	-	-	-	-	-	-	-	-	-	-	UbiA
k59_1189102_1	762963.HMPREF9056_00409	2.44e-39	150.0	COG5263@1|root,COG5479@1|root,COG5263@2|Bacteria,COG5479@2|Bacteria,2GNDB@201174|Actinobacteria,4D3RQ@85005|Actinomycetales	201174|Actinobacteria	M	N-acetylmuramoyl-L-alanine amidase	csp	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,LGFP
k59_836367_1	1461694.ATO9_12480	1.69e-50	187.0	COG0771@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2V8V8@28211|Alphaproteobacteria,2PFGF@252301|Oceanicola	28211|Alphaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1189105_2	448385.sce4763	3.06e-44	159.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,42PMM@68525|delta/epsilon subdivisions,2X37C@28221|Deltaproteobacteria,2YUQZ@29|Myxococcales	28221|Deltaproteobacteria	S	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
k59_1540407_1	1267005.KB911255_gene2763	4.81e-100	293.0	COG1376@1|root,COG1376@2|Bacteria,1NHM3@1224|Proteobacteria,2UHVV@28211|Alphaproteobacteria,3N8IS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_1840641_1	1120988.AXWV01000041_gene825	2.03e-26	97.4	COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,1SCEJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
k59_1840641_2	631362.Thi970DRAFT_03282	1.45e-40	134.0	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,1S8UG@1236|Gammaproteobacteria,1WYZ3@135613|Chromatiales	135613|Chromatiales	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
k59_1840641_3	1429851.X548_20735	5.63e-08	53.1	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,1X4CG@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
k59_132369_1	204773.HEAR1601	2.74e-09	57.4	COG1285@1|root,COG1285@2|Bacteria,1MURJ@1224|Proteobacteria,2W2IK@28216|Betaproteobacteria,478R5@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	MgtC family	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
k59_132369_2	266835.14021654	4.87e-19	88.2	COG4318@1|root,COG4318@2|Bacteria,1MVIY@1224|Proteobacteria,2TSB0@28211|Alphaproteobacteria,43NZ6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Putative ParB-like nuclease	-	-	-	-	-	-	-	-	-	-	-	-	ParBc_2
k59_1076929_1	765910.MARPU_00855	3.37e-193	547.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1WXB2@135613|Chromatiales	135613|Chromatiales	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
k59_836381_2	720555.BATR1942_01065	4.55e-12	69.7	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UZKW@1239|Firmicutes,4HF1S@91061|Bacilli,1ZPXG@1386|Bacillus	91061|Bacilli	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
k59_373034_1	1307761.L21SP2_1019	9.57e-110	338.0	COG0010@1|root,COG3457@1|root,COG0010@2|Bacteria,COG3457@2|Bacteria,2JA1N@203691|Spirochaetes	203691|Spirochaetes	E	Alanine racemase, N-terminal domain	-	-	5.1.1.12	ko:K21898	ko00472,map00472	-	R00672	RC00302	ko00000,ko00001,ko01000	-	-	-	Ala_racemase_N
k59_373034_2	555079.Toce_1485	2.01e-25	105.0	COG2185@1|root,COG2185@2|Bacteria,1UJHA@1239|Firmicutes,25F35@186801|Clostridia	186801|Clostridia	I	D-Lysine 5,6-aminomutase alpha subunit	-	-	5.4.3.5	ko:K17898	ko00472,map00472	-	R02461	RC00719	ko00000,ko00001,ko01000	-	-	-	B12-binding,Lys-AminoMut_A,OAM_dimer
k59_1189116_1	883066.HMPREF9233_00242	8.65e-37	141.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4D3YV@85005|Actinomycetales	201174|Actinobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_1189116_2	1110502.TMO_3482	4.82e-35	130.0	COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,2TU4P@28211|Alphaproteobacteria,2JPXU@204441|Rhodospirillales	204441|Rhodospirillales	V	COG0842 ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_1598766_1	1121106.JQKB01000072_gene881	3.52e-26	99.4	COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_1598766_2	411684.HPDFL43_01400	1.09e-10	62.4	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,43IUV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_601047_1	1279019.ARQK01000053_gene2114	4.78e-53	178.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1SKFC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_901297_1	378806.STAUR_0336	5.67e-61	209.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42R6X@68525|delta/epsilon subdivisions,2WMY9@28221|Deltaproteobacteria,2Z18Z@29|Myxococcales	28221|Deltaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_257246_1	999550.KI421507_gene2094	6.53e-07	50.4	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2TSW3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	N-acetylmuramoyl-L-alanine amidase	ampD	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	2.5.1.3,3.5.1.28	ko:K00788,ko:K01447,ko:K03806,ko:K11066	ko00730,ko01100,map00730,map01100	M00127	R03223,R04112,R10712	RC00064,RC00141,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Amidase_2,PG_binding_1
k59_1364470_1	1125700.HMPREF9195_01651	3.47e-31	125.0	COG3250@1|root,COG3250@2|Bacteria,2J5N4@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 2 family	lacZ	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_1010212_1	768671.ThimaDRAFT_2667	2.87e-30	123.0	COG2319@1|root,COG2319@2|Bacteria,1MWJA@1224|Proteobacteria,1T4BE@1236|Gammaproteobacteria,1WW20@135613|Chromatiales	135613|Chromatiales	T	WD40 repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DUF4062,WD40
k59_23619_1	292415.Tbd_1446	2.83e-69	227.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,2VJIQ@28216|Betaproteobacteria,1KSJ5@119069|Hydrogenophilales	119069|Hydrogenophilales	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8
k59_1251283_1	1122611.KB903940_gene2055	2.27e-126	387.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4EGTA@85012|Streptosporangiales	201174|Actinobacteria	P	Cation transporter/ATPase, N-terminus	ctpF	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.8	ko:K01537,ko:K12953	-	-	-	-	ko00000,ko01000	3.A.3,3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_1424100_1	935839.JAGJ01000004_gene1957	5.74e-144	420.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,4F39K@85017|Promicromonosporaceae	201174|Actinobacteria	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1251285_1	572477.Alvin_2212	3.52e-100	307.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1WWPJ@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
k59_132385_1	1121033.AUCF01000012_gene990	5.17e-62	207.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,2JPVD@204441|Rhodospirillales	204441|Rhodospirillales	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	-	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8
k59_1251287_1	1049564.TevJSym_aa01610	2.75e-10	62.0	COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,1RS2S@1236|Gammaproteobacteria,1J5V4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	fliD	GO:0001539,GO:0003674,GO:0005198,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009420,GO:0009421,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,FliD_C,FliD_N
k59_1251287_2	765914.ThisiDRAFT_2568	7.05e-42	142.0	COG1516@1|root,COG1516@2|Bacteria,1MZ3G@1224|Proteobacteria,1S8TQ@1236|Gammaproteobacteria,1WYGU@135613|Chromatiales	135613|Chromatiales	N	flagellar protein FliS	-	-	-	ko:K02422	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliS
k59_23628_1	7370.XP_005190835.1	3.2e-11	69.7	COG5184@1|root,KOG1426@2759|Eukaryota,39G0B@33154|Opisthokonta,3BDQC@33208|Metazoa,3CSPJ@33213|Bilateria,41WRC@6656|Arthropoda,3SIQ0@50557|Insecta,44Y9D@7147|Diptera	33208|Metazoa	DZ	Regulator of chromosome	RCC1	GO:0000082,GO:0000226,GO:0000228,GO:0000278,GO:0000785,GO:0000790,GO:0000793,GO:0000794,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0005085,GO:0005087,GO:0005088,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005654,GO:0005694,GO:0005737,GO:0006606,GO:0006607,GO:0006810,GO:0006886,GO:0006913,GO:0006996,GO:0007010,GO:0007017,GO:0007049,GO:0007051,GO:0007052,GO:0007059,GO:0007088,GO:0007275,GO:0007346,GO:0007399,GO:0007417,GO:0008104,GO:0008150,GO:0008536,GO:0009790,GO:0009792,GO:0009987,GO:0010564,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016032,GO:0016043,GO:0017016,GO:0017038,GO:0019899,GO:0022008,GO:0022402,GO:0022607,GO:0030154,GO:0031090,GO:0031267,GO:0031490,GO:0031491,GO:0031492,GO:0031965,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032386,GO:0032501,GO:0032502,GO:0032879,GO:0032991,GO:0033036,GO:0033043,GO:0033365,GO:0034504,GO:0034613,GO:0042393,GO:0042886,GO:0043167,GO:0043168,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044770,GO:0044772,GO:0044843,GO:0044877,GO:0045184,GO:0045595,GO:0046822,GO:0046907,GO:0046982,GO:0046983,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050789,GO:0050793,GO:0050794,GO:0051020,GO:0051049,GO:0051128,GO:0051169,GO:0051170,GO:0051179,GO:0051225,GO:0051234,GO:0051239,GO:0051259,GO:0051262,GO:0051290,GO:0051291,GO:0051641,GO:0051649,GO:0051704,GO:0051726,GO:0051783,GO:0051960,GO:0060284,GO:0060341,GO:0065003,GO:0065007,GO:0065009,GO:0070013,GO:0070727,GO:0070925,GO:0071702,GO:0071705,GO:0071840,GO:0072594,GO:0097159,GO:0098772,GO:1901363,GO:1901681,GO:1902850,GO:1903047,GO:2000026	-	ko:K11493	-	-	-	-	ko00000,ko03019,ko03036	-	-	-	RCC1,RCC1_2
k59_601058_1	357804.Ping_1039	4.18e-30	115.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock. Lacks autonomous chaperone activity	cbpA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0097159,GO:1901363	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
k59_601058_2	1116472.MGMO_145c00070	1.95e-24	96.3	COG0789@1|root,COG0789@2|Bacteria,1N9MT@1224|Proteobacteria,1SE7J@1236|Gammaproteobacteria,1XFP5@135618|Methylococcales	135618|Methylococcales	K	MerR HTH family regulatory protein	-	-	-	ko:K18997	-	-	-	-	ko00000,ko03036	-	-	-	MerR_2
k59_1716377_1	1242864.D187_008763	6.96e-46	158.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,42R8B@68525|delta/epsilon subdivisions,2X5KI@28221|Deltaproteobacteria,2YUUJ@29|Myxococcales	28221|Deltaproteobacteria	L	Endonuclease/Exonuclease/phosphatase family	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_1598783_1	1049564.TevJSym_ap00710	2.36e-70	215.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,1J60X@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_1486305_1	1547437.LL06_25465	4.52e-88	266.0	COG1346@1|root,COG1346@2|Bacteria,1MV81@1224|Proteobacteria,2TSP3@28211|Alphaproteobacteria,43Q6M@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	LrgB-like family	-	-	-	-	-	-	-	-	-	-	-	-	LrgB
k59_23634_2	391616.OA238_c38840	9.78e-72	228.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_1189140_1	366602.Caul_3942	9.33e-17	81.3	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2KFVS@204458|Caulobacterales	204458|Caulobacterales	S	Sulfotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_14,TPR_16,TPR_19,TPR_8
k59_1189140_2	1163409.UUA_08376	3.27e-23	100.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria,1X3QV@135614|Xanthomonadales	135614|Xanthomonadales	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.5.8.1,1.5.8.2	ko:K00317	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R01588,R02511	RC00185,RC00556,RC00557,RC00732	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
k59_425235_1	118005.AWNK01000003_gene2230	2.69e-260	739.0	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria	2|Bacteria	G	chondroitin AC lyase activity	ndvB	-	2.4.1.12,3.2.1.58	ko:K00694,ko:K01210,ko:K03292	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R00308,R02889,R03115	RC00005,RC00467	ko00000,ko00001,ko01000,ko01003,ko02000	2.A.2,4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Glyco_hydro_17,Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,MFS_2
k59_373070_2	595460.RRSWK_04197	3.79e-53	171.0	COG5500@1|root,COG5500@2|Bacteria,2J3PN@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF1772)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1772
k59_542815_1	1049564.TevJSym_as00320	2.29e-107	317.0	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria,1J5TZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	COG0501 Zn-dependent protease with chaperone function	Z012_09445	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_132401_1	96561.Dole_0720	2.24e-71	218.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,42QS6@68525|delta/epsilon subdivisions,2WMPD@28221|Deltaproteobacteria,2MJFM@213118|Desulfobacterales	28221|Deltaproteobacteria	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_1010230_1	402881.Plav_1288	1.64e-29	118.0	COG0457@1|root,COG0457@2|Bacteria,1NG0U@1224|Proteobacteria,2U0YA@28211|Alphaproteobacteria,1JNV7@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
k59_837181_1	1525715.IX54_04725	1.05e-22	102.0	COG2979@1|root,COG2979@2|Bacteria,1REJ3@1224|Proteobacteria,2U7XR@28211|Alphaproteobacteria,2PW6S@265|Paracoccus	28211|Alphaproteobacteria	S	Protein of unknown function (DUF533)	-	-	-	-	-	-	-	-	-	-	-	-	DUF533
k59_1775693_1	471853.Bcav_0840	3.96e-25	100.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoP	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1841846_1	305900.GV64_09815	2.97e-99	305.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1XI2S@135619|Oceanospirillales	135619|Oceanospirillales	J	Involved in the processing of the 5'end of 16S rRNA	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_543564_1	1191523.MROS_1522	4.15e-06	54.3	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
k59_661527_1	710685.MycrhN_1390	9.65e-08	52.4	COG1028@1|root,COG1028@2|Bacteria,2IBHM@201174|Actinobacteria,235RR@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1841851_1	582899.Hden_3323	8.54e-108	320.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria,3N6AE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_909509_1	1000565.METUNv1_02313	1.2e-49	176.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,2KU6T@206389|Rhodocyclales	206389|Rhodocyclales	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_607088_1	395493.BegalDRAFT_1376	4.82e-17	82.8	COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,460I1@72273|Thiotrichales	72273|Thiotrichales	D	Part of the ABC transporter FtsEX involved in cellular division	-	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
k59_1084645_1	1713.JOFV01000010_gene1199	2.53e-104	309.0	COG0024@1|root,COG0024@2|Bacteria,2GKKB@201174|Actinobacteria,4F0VK@85016|Cellulomonadaceae	201174|Actinobacteria	J	TIGRFAM methionine aminopeptidase, type I	mapA	GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016020,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901605	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_1370359_1	1123065.ATWL01000025_gene1855	2.72e-63	223.0	COG2378@1|root,COG2378@2|Bacteria,2I8XQ@201174|Actinobacteria	201174|Actinobacteria	K	Helicase conserved C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_3
k59_724877_1	1049564.TevJSym_bp00160	9.81e-93	282.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1J5CN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	COG4992 Ornithine acetylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1430075_2	1049564.TevJSym_bf00120	4.14e-47	161.0	COG1897@1|root,COG1897@2|Bacteria,1MV64@1224|Proteobacteria,1RM7T@1236|Gammaproteobacteria,1J6TN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	metAS	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0008899,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.46	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	M00017	R01777	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	iECUMN_1333.ECUMN_4539,iSBO_1134.SBO_4033,iSbBS512_1146.SbBS512_E4507	HTS
k59_87683_1	595593.JREV01000042_gene3956	9.93e-10	64.3	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,1W808@1268|Micrococcaceae	201174|Actinobacteria	KLT	Protein tyrosine kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k59_313957_1	56780.SYN_01409	3.41e-67	224.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42N5M@68525|delta/epsilon subdivisions,2WIIV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2763	Aconitase,Aconitase_C
k59_1320758_1	265729.GS18_0200215	7.54e-92	279.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,4H9YB@91061|Bacilli,1ZBA4@1386|Bacillus	91061|Bacilli	E	Belongs to the ABC transporter superfamily	appF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_381235_1	367299.JOEE01000003_gene2900	8.84e-59	187.0	COG2884@1|root,COG2884@2|Bacteria,2GJE1@201174|Actinobacteria,4FF75@85021|Intrasporangiaceae	201174|Actinobacteria	D	Cell division	ftsE	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_381235_2	367299.JOEE01000003_gene2899	1.31e-41	144.0	COG2177@1|root,COG2177@2|Bacteria,2GJMA@201174|Actinobacteria,4FE39@85021|Intrasporangiaceae	201174|Actinobacteria	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
k59_968527_2	572477.Alvin_2725	6.71e-41	151.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1WWAD@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_1546273_1	1123393.KB891316_gene1212	2.61e-88	267.0	28I2K@1|root,2ZAEK@2|Bacteria,1R9HK@1224|Proteobacteria,2VZM5@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_909538_1	1443665.JACA01000023_gene3713	6.05e-35	136.0	COG1574@1|root,COG1574@2|Bacteria,4NFMV@976|Bacteroidetes,1HZ70@117743|Flavobacteriia,2YGMM@290174|Aquimarina	976|Bacteroidetes	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_968533_1	1121887.AUDK01000004_gene431	9.4e-14	77.4	COG2911@1|root,COG3210@1|root,COG3533@1|root,COG4625@1|root,COG4733@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG3533@2|Bacteria,COG4625@2|Bacteria,COG4733@2|Bacteria,4PPKP@976|Bacteroidetes,1IKQ3@117743|Flavobacteriia,2P0T3@237|Flavobacterium	976|Bacteroidetes	U	Alginate lyase	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Laminin_G_3
k59_313966_1	1049564.TevJSym_be00360	2.19e-29	120.0	COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1T213@1236|Gammaproteobacteria,1J5VV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	signal transduction histidine kinase	phoQ	-	2.7.13.3	ko:K07637	ko01503,ko02020,map01503,map02020	M00444,M00709,M00721,M00723,M00724,M00744	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HATPase_c,PhoQ_Sensor
k59_968537_1	1121013.P873_04140	3.92e-69	218.0	COG0491@1|root,COG0491@2|Bacteria,1R4FA@1224|Proteobacteria,1S1QD@1236|Gammaproteobacteria,1X36I@135614|Xanthomonadales	135614|Xanthomonadales	S	metallo-beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_381256_1	926564.KI911624_gene4090	1.26e-28	113.0	COG0715@1|root,COG0715@2|Bacteria,2HH8J@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	ssuA_3	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
k59_1493358_1	1304865.JAGF01000001_gene719	1.13e-102	317.0	COG5337@1|root,COG5337@2|Bacteria,2GN9M@201174|Actinobacteria,4F20J@85016|Cellulomonadaceae	201174|Actinobacteria	M	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH
k59_1493358_2	1123072.AUDH01000015_gene2153	0.000928	48.5	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,2JQS7@204441|Rhodospirillales	204441|Rhodospirillales	P	COG0474 Cation transport ATPase	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_489892_1	1116472.MGMO_17c00180	7.95e-98	310.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1XDY0@135618|Methylococcales	135618|Methylococcales	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1015203_1	1121106.JQKB01000002_gene3334	4.12e-06	48.1	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2TRK9@28211|Alphaproteobacteria,2JPHM@204441|Rhodospirillales	204441|Rhodospirillales	I	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep,Hexapep_2
k59_1015203_2	240016.ABIZ01000001_gene4595	7.59e-45	159.0	COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,46SG1@74201|Verrucomicrobia,2ITYH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	IM	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	fabZ	-	3.5.1.108,4.2.1.59	ko:K16363	ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212	M00060,M00083	R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965	RC00166,RC00300,RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005	-	-	-	FabA,LpxC
k59_1015203_3	4792.ETI45680	8.91e-15	76.6	KOG2352@1|root,KOG2352@2759|Eukaryota,3Q70N@4776|Peronosporales	4776|Peronosporales	E	polyadenylation-dependent snoRNA 3'-end processing	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
k59_1546285_1	743722.Sph21_5118	1.26e-15	77.8	COG0405@1|root,COG0405@2|Bacteria,4NG3X@976|Bacteroidetes,1IPXR@117747|Sphingobacteriia	976|Bacteroidetes	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1546285_3	471854.Dfer_2714	5.93e-20	91.3	COG1473@1|root,COG1473@2|Bacteria,4NGBI@976|Bacteroidetes,47JXE@768503|Cytophagia	976|Bacteroidetes	S	PFAM Peptidase family M20 M25 M40	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_431061_1	335543.Sfum_2378	1.04e-102	312.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,42MST@68525|delta/epsilon subdivisions,2WKAN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
k59_196776_1	426114.THI_3253	4.84e-15	79.7	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2VKS0@28216|Betaproteobacteria,1KMIV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_197493_1	472759.Nhal_2070	6.45e-49	177.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1WWJI@135613|Chromatiales	135613|Chromatiales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_1781535_1	1151119.KB895497_gene3334	1.21e-06	53.5	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2,AP_endonuc_2_N
k59_549205_1	671143.DAMO_2213	4.02e-44	158.0	COG1078@1|root,COG1078@2|Bacteria,2NPZN@2323|unclassified Bacteria	2|Bacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
k59_725610_2	367299.JOEE01000004_gene1403	3.97e-21	88.2	COG1714@1|root,COG1714@2|Bacteria,2IQMG@201174|Actinobacteria,4FHT2@85021|Intrasporangiaceae	201174|Actinobacteria	S	PFAM RDD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	RDD
k59_1781539_1	1713.JOFV01000002_gene616	1.65e-56	192.0	COG2723@1|root,COG2723@2|Bacteria,2GJAF@201174|Actinobacteria,4F0XE@85016|Cellulomonadaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 1	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
k59_725614_1	211114.JOEF01000032_gene1954	1.48e-24	99.8	2AVV0@1|root,31MNQ@2|Bacteria,2GJKP@201174|Actinobacteria,4E2PK@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF3159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3159
k59_725614_2	43354.JOIJ01000008_gene3005	2.38e-31	116.0	COG0266@1|root,COG0266@2|Bacteria,2GKUI@201174|Actinobacteria,4E0QZ@85010|Pseudonocardiales	201174|Actinobacteria	L	Belongs to the FPG family	nei1	GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0003906,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034599,GO:0034641,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070887,GO:0071704,GO:0090304,GO:0097159,GO:0097506,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K05522,ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_1322076_1	713586.KB900537_gene3288	6.17e-34	136.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_843117_1	314285.KT71_03017	1.01e-45	170.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1RWT6@1236|Gammaproteobacteria,1J7Y7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1665810_1	237368.SCABRO_03668	1.29e-30	124.0	COG5421@1|root,COG5421@2|Bacteria,2J33B@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1322083_1	522306.CAP2UW1_3863	2.68e-16	81.6	COG1008@1|root,COG1008@2|Bacteria,1R6UV@1224|Proteobacteria,2VHFZ@28216|Betaproteobacteria,1KR8C@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1322083_2	1049564.TevJSym_ad00280	4.4e-37	139.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1J4U3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CP	CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	-	-	1.6.5.3	ko:K05577	ko00190,ko01100,map00190,map01100	M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	-	-	-	Proton_antipo_M,Proton_antipo_N
k59_431826_1	1123253.AUBD01000002_gene1204	1.38e-95	302.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1X3EQ@135614|Xanthomonadales	135614|Xanthomonadales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
k59_314798_1	765912.Thimo_1686	1.48e-94	295.0	COG0480@1|root,COG0480@2|Bacteria,1PMU3@1224|Proteobacteria,1S00P@1236|Gammaproteobacteria,1WXBY@135613|Chromatiales	135613|Chromatiales	J	small GTP-binding protein	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_843127_2	768671.ThimaDRAFT_3507	4.15e-27	108.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,1WVX4@135613|Chromatiales	135613|Chromatiales	I	TIGRFAM acetyl-CoA carboxylase, biotin carboxylase	-	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_490645_1	367299.JOEE01000001_gene1879	2.73e-97	297.0	COG4147@1|root,COG4147@2|Bacteria,2GM3H@201174|Actinobacteria,4FFFQ@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_197519_1	1500894.JQNN01000001_gene4599	2.51e-15	87.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,473ZF@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_1850333_1	670307.HYPDE_36878	2.12e-107	323.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,3N6EF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
k59_1494337_1	396588.Tgr7_2051	2.74e-37	136.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1WWD4@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_1494337_2	765952.PUV_11640	2.81e-23	92.0	COG0105@1|root,COG0105@2|Bacteria,2JG27@204428|Chlamydiae	204428|Chlamydiae	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk2	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
k59_34142_1	224911.27350644	2.69e-86	271.0	COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,2TRUJ@28211|Alphaproteobacteria,3JQY8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	MA20_45030	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_1015881_1	472759.Nhal_1189	3.08e-80	264.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_549234_2	498211.CJA_1897	5.87e-53	177.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,1FHFN@10|Cellvibrio	1236|Gammaproteobacteria	T	Metal dependent phosphohydrolases with conserved 'HD' motif.	rpfG	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,Response_reg
k59_607913_2	243231.GSU0573	4.18e-41	146.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,42MY6@68525|delta/epsilon subdivisions,2WMDC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_969894_1	519989.ECTPHS_05325	7.46e-146	421.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1WW43@135613|Chromatiales	135613|Chromatiales	J	TIGRFAM Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_969894_2	1121116.KB894765_gene906	2.92e-05	47.4	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,2VHAM@28216|Betaproteobacteria,4AC87@80864|Comamonadaceae	28216|Betaproteobacteria	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
k59_1850347_2	441620.Mpop_3223	2.29e-87	273.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TTE1@28211|Alphaproteobacteria,1JT8D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
k59_1085652_1	196162.Noca_0440	6.19e-82	256.0	COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria,4DNQY@85009|Propionibacteriales	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
k59_969913_1	862751.SACTE_2876	7.69e-87	271.0	COG2273@1|root,COG2273@2|Bacteria,2GJQP@201174|Actinobacteria	201174|Actinobacteria	G	PFAM glycoside hydrolase, family 16	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16,Ricin_B_lectin
k59_490666_1	1109445.AGSX01000186_gene2359	3.47e-67	216.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,1Z0ND@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	E	COG0436 Aspartate tyrosine aromatic aminotransferase	dapC	-	2.6.1.17	ko:K14261,ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_667211_1	670307.HYPDE_30528	2.16e-110	333.0	COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2TQKA@28211|Alphaproteobacteria,3N62K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
k59_1547021_1	1121033.AUCF01000026_gene2913	2.2e-133	387.0	COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria,2JR4P@204441|Rhodospirillales	204441|Rhodospirillales	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_1371117_1	713587.THITH_02145	7.57e-92	280.0	COG1910@1|root,COG1910@2|Bacteria,1MVS4@1224|Proteobacteria,1RY8Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,PBP_like
k59_1371117_2	298386.PBPRA1888	4.17e-26	109.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XTA5@135623|Vibrionales	135623|Vibrionales	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_969922_1	391615.ABSJ01000038_gene417	5.93e-27	107.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1J4NI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Signal transduction histidine kinase, nitrogen specific	glnL	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
k59_969922_2	1333856.L686_01995	1.39e-88	275.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1Z0M4@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	glnG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_89090_1	713586.KB900536_gene2702	5.09e-57	197.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,1WWF7@135613|Chromatiales	135613|Chromatiales	H	TonB-dependent Receptor Plug	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
k59_1605203_1	1163617.SCD_n00309	3.35e-43	149.0	COG0500@1|root,COG2226@2|Bacteria,1RDI3@1224|Proteobacteria	1224|Proteobacteria	Q	Pfam Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
k59_89099_1	1267005.KB911264_gene3169	1.1e-30	117.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2TSUZ@28211|Alphaproteobacteria,3N685@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	-	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_8
k59_1665868_1	713586.KB900536_gene484	5.22e-35	132.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1WVVK@135613|Chromatiales	135613|Chromatiales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_267844_2	745411.B3C1_17912	5.83e-21	94.0	COG3137@1|root,COG3137@2|Bacteria,1N9KB@1224|Proteobacteria,1S68E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Protein of unknown function, DUF481	-	-	-	ko:K07283	-	-	-	-	ko00000	-	-	-	DUF481
k59_1015911_2	1049564.TevJSym_bm00090	1.15e-52	169.0	COG3118@1|root,COG3118@2|Bacteria,1RHRZ@1224|Proteobacteria,1S7F0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_382683_1	648757.Rvan_3213	2.14e-40	150.0	COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria,2TZ0I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c3	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
k59_1085685_1	1245471.PCA10_21870	4.37e-89	268.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,1RXE9@1236|Gammaproteobacteria,1YJ0W@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1322184_1	34007.IT40_17345	1.13e-16	79.7	COG0464@1|root,COG0464@2|Bacteria,1MUCN@1224|Proteobacteria,2TVFY@28211|Alphaproteobacteria,2PUIZ@265|Paracoccus	28211|Alphaproteobacteria	O	ATPase family associated with various cellular activities (AAA)	cbbX	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_1322184_2	640511.BC1002_3210	1.28e-45	161.0	COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,2VIJT@28216|Betaproteobacteria,1K0KJ@119060|Burkholderiaceae	28216|Betaproteobacteria	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp2	-	3.1.3.11,3.1.3.37	ko:K01086,ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R01845,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
k59_314846_1	697282.Mettu_2217	1.46e-40	144.0	COG0430@1|root,COG0430@2|Bacteria,1MX7Q@1224|Proteobacteria,1RSFF@1236|Gammaproteobacteria,1XE7B@135618|Methylococcales	135618|Methylococcales	A	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009975,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
k59_1605218_1	1122137.AQXF01000006_gene926	7.72e-35	129.0	COG2992@1|root,COG2992@2|Bacteria,1RD3U@1224|Proteobacteria,2U71B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	FlgJ-related protein	bax	-	-	ko:K03796	-	-	-	-	ko00000	-	GH73	-	Glucosaminidase
k59_1322189_1	326427.Cagg_2342	4.93e-59	204.0	COG0477@1|root,COG2814@2|Bacteria,2G6DM@200795|Chloroflexi,375GE@32061|Chloroflexia	32061|Chloroflexia	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K08151	-	M00668	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75	-	-	MFS_1,Sugar_tr
k59_1850408_1	768671.ThimaDRAFT_1821	8.12e-62	211.0	COG1680@1|root,COG1680@2|Bacteria,1PGQT@1224|Proteobacteria,1SWR7@1236|Gammaproteobacteria,1X19R@135613|Chromatiales	135613|Chromatiales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_781014_1	298655.KI912266_gene1775	1.68e-120	360.0	COG4603@1|root,COG4603@2|Bacteria,2GKAZ@201174|Actinobacteria,4EU1I@85013|Frankiales	201174|Actinobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_781014_2	298655.KI912266_gene1774	2.23e-08	54.3	COG1079@1|root,COG1079@2|Bacteria,2GKMB@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_1665884_1	1333856.L686_00990	2.13e-49	182.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1YZXM@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	U	COG4796 Type II secretory pathway, component HofQ	pilQ	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	-	ko:K02507,ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_382709_1	237727.NAP1_09667	8.93e-19	88.2	COG1082@1|root,COG1082@2|Bacteria,1NNTS@1224|Proteobacteria,2U06E@28211|Alphaproteobacteria,2K1T2@204457|Sphingomonadales	204457|Sphingomonadales	G	Glycosyl-hydrolase 97 C-terminal, oligomerisation	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	GH97_C,GH97_N,Glyco_hydro_97
k59_89138_1	103733.JNYO01000025_gene8924	2.31e-110	335.0	COG1032@1|root,COG1032@2|Bacteria,2ISAI@201174|Actinobacteria	201174|Actinobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_143771_1	1454004.AW11_02394	7.42e-209	588.0	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VHA3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Phospholipase, patatin family	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_143773_1	498211.CJA_1505	8.49e-49	176.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1FG0D@10|Cellvibrio	1236|Gammaproteobacteria	C	2-oxoglutarate dehydrogenase N-terminus	sucA	GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1375720_1	1117647.M5M_01710	2.34e-118	358.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,1J4Y1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0042802,GO:0043021,GO:0043022,GO:0043170,GO:0043335,GO:0043412,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0051083,GO:0061077,GO:0071704,GO:0140096,GO:1901564	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
k59_391377_1	1123519.PSJM300_10225	1.65e-31	119.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,1S22I@1236|Gammaproteobacteria,1YZT8@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	GO:0003674,GO:0003824,GO:0004416,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
k59_391377_2	1249627.D779_2322	3.11e-81	248.0	COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,1RMS7@1236|Gammaproteobacteria,1WWCG@135613|Chromatiales	135613|Chromatiales	C	PFAM Phosphoribulokinase uridine kinase	-	-	2.7.1.19	ko:K00855	ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200	M00165,M00166	R01523	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
k59_978844_1	748658.KB907318_gene1063	6.34e-95	296.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,1RR35@1236|Gammaproteobacteria,1WXAB@135613|Chromatiales	135613|Chromatiales	P	TrkA-N domain	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_N
k59_1609806_1	1437610.BREU_1196	2.46e-79	245.0	COG1209@1|root,COG1209@2|Bacteria,2GP20@201174|Actinobacteria,4CZ5F@85004|Bifidobacteriales	201174|Actinobacteria	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005996,GO:0006006,GO:0006139,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009117,GO:0009141,GO:0009147,GO:0009200,GO:0009211,GO:0009219,GO:0009225,GO:0009226,GO:0009262,GO:0009394,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019299,GO:0019300,GO:0019305,GO:0019318,GO:0019319,GO:0019438,GO:0019637,GO:0019692,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0045226,GO:0046075,GO:0046364,GO:0046379,GO:0046383,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0334	NTP_transferase
k59_319809_1	85643.Tmz1t_3198	3.78e-07	54.3	COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,2VIV2@28216|Betaproteobacteria,2KVXE@206389|Rhodocyclales	206389|Rhodocyclales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_672048_2	261292.Nit79A3_3002	8.86e-20	93.2	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,3724V@32003|Nitrosomonadales	28216|Betaproteobacteria	I	acyl-CoA dehydrogenase	fadE	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_1609813_1	446469.Sked_09370	7.33e-11	64.7	COG1040@1|root,COG1040@2|Bacteria,2I9PA@201174|Actinobacteria	201174|Actinobacteria	S	phosphoribosyltransferase	pyrE_1	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
k59_274290_1	290399.Arth_0757	9.48e-70	216.0	COG3409@1|root,COG3409@2|Bacteria,2IM37@201174|Actinobacteria,1WBE2@1268|Micrococcaceae	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_554187_1	1121889.AUDM01000049_gene1307	5.84e-14	76.3	COG3666@1|root,COG3666@2|Bacteria,4NEDD@976|Bacteroidetes,1HYXT@117743|Flavobacteriia,2NVAA@237|Flavobacterium	976|Bacteroidetes	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1091264_2	1122599.AUGR01000004_gene2205	6.4e-63	199.0	COG2176@1|root,COG2176@2|Bacteria,1QUVW@1224|Proteobacteria,1RM8J@1236|Gammaproteobacteria,1XNJ0@135619|Oceanospirillales	135619|Oceanospirillales	L	3' exoribonuclease, RNase T-like	-	-	-	-	-	-	-	-	-	-	-	-	RNase_T
k59_1551664_1	367299.JOEE01000008_gene457	1.64e-54	181.0	COG2326@1|root,COG2326@2|Bacteria,2GKRN@201174|Actinobacteria,4FFBT@85021|Intrasporangiaceae	201174|Actinobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_391416_1	561175.KB894097_gene217	1.4e-24	98.6	COG1579@1|root,COG1579@2|Bacteria,2GP84@201174|Actinobacteria,4EH3Z@85012|Streptosporangiales	201174|Actinobacteria	S	C4-type zinc ribbon domain	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
k59_391416_2	1214242.B446_12040	6.09e-56	193.0	COG0328@1|root,COG0406@1|root,COG0328@2|Bacteria,COG0406@2|Bacteria,2GJ9R@201174|Actinobacteria	201174|Actinobacteria	GL	phosphoglycerate mutase	-	-	3.1.26.4,3.1.3.73	ko:K02226,ko:K22316	ko00860,ko01100,ko03030,map00860,map01100,map03030	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	His_Phos_1,RVT_3
k59_41121_2	265072.Mfla_1763	3.43e-17	83.6	COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,2VTYR@28216|Betaproteobacteria,2KN1Z@206350|Nitrosomonadales	206350|Nitrosomonadales	O	HupE / UreJ protein	-	-	-	ko:K03192	-	-	-	-	ko00000	-	-	-	HupE_UreJ
k59_730627_1	1232410.KI421416_gene2619	8.48e-83	254.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WM7T@28221|Deltaproteobacteria,43TRG@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran,DUF4162
k59_1859388_2	1249627.D779_3802	6.16e-66	216.0	COG2214@1|root,COG2981@1|root,COG2214@2|Bacteria,COG2981@2|Bacteria,1MVFT@1224|Proteobacteria,1RMQT@1236|Gammaproteobacteria,1WWYG@135613|Chromatiales	135613|Chromatiales	E	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway	cysZ	-	-	ko:K06203	-	-	-	-	ko00000	-	-	-	DnaJ,EI24
k59_1375760_1	521393.JH806633_gene1804	2.98e-63	207.0	COG1560@1|root,COG1560@2|Bacteria,2GM7B@201174|Actinobacteria,4D43F@85005|Actinomycetales	201174|Actinobacteria	M	Lipid A biosynthesis	htrB	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.3.1.265	ko:K22311	-	-	-	-	ko00000,ko01000	-	-	-	Lip_A_acyltrans
k59_1785815_1	1121439.dsat_1711	1.22e-81	257.0	COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,42PJC@68525|delta/epsilon subdivisions,2WJB9@28221|Deltaproteobacteria,2M980@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	ATP synthase alpha/beta family, beta-barrel domain	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_319842_1	102232.GLO73106DRAFT_00029500	4.3e-12	73.2	COG2931@1|root,COG3386@1|root,COG2931@2|Bacteria,COG3386@2|Bacteria,1G3DW@1117|Cyanobacteria	1117|Cyanobacteria	Q	Polymorphic membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4114,DUF4347,HemolysinCabind
k59_319842_2	1313172.YM304_11550	2.97e-10	62.0	COG2035@1|root,COG2035@2|Bacteria,2I8HU@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	ko:K08974	-	-	-	-	ko00000	-	-	-	DUF368
k59_1728270_1	452637.Oter_2109	1.04e-85	261.0	COG0180@1|root,COG0180@2|Bacteria,46SA6@74201|Verrucomicrobia,3K7UW@414999|Opitutae	414999|Opitutae	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_1859406_1	402881.Plav_0582	3.03e-19	84.0	COG1586@1|root,COG1586@2|Bacteria,1RH88@1224|Proteobacteria,2U5D3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speH	-	2.5.1.16,4.1.1.50	ko:K00797,ko:K01611	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R00178,R01920,R02869,R08359	RC00021,RC00053,RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc,Spermine_synt_N,Spermine_synth
k59_919812_1	706587.Desti_0964	2.68e-122	384.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,42P6X@68525|delta/epsilon subdivisions,2WK8U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
k59_143829_1	1134474.O59_000505	9.12e-38	140.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,1FG23@10|Cellvibrio	1236|Gammaproteobacteria	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_1375773_1	1125863.JAFN01000001_gene1039	1.77e-34	135.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2WJ1G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
k59_1859412_1	765912.Thimo_0084	4.72e-61	195.0	COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,1S3S0@1236|Gammaproteobacteria,1WY4Z@135613|Chromatiales	135613|Chromatiales	NU	PFAM Fimbrial assembly	-	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
k59_1859412_2	1049564.TevJSym_bb00160	6.63e-08	52.8	COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1J6DF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	Pilus assembly protein, PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
k59_919821_1	522306.CAP2UW1_1017	1.52e-09	61.6	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2VHBA@28216|Betaproteobacteria,1KR7P@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function DUF21	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1331146_1	861299.J421_3848	1.44e-103	318.0	COG0443@1|root,COG0443@2|Bacteria,1ZT75@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_391472_1	1120936.KB907222_gene2322	5.19e-42	162.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria,4ER96@85012|Streptosporangiales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
k59_1138585_2	713586.KB900536_gene3029	5.27e-63	204.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1WXB7@135613|Chromatiales	135613|Chromatiales	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_319857_1	1249627.D779_0025	2.86e-77	256.0	COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,1WXH7@135613|Chromatiales	135613|Chromatiales	I	SMART Phospholipid glycerol acyltransferase	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase,MFS_1
k59_98058_1	177437.HRM2_26600	1.81e-85	271.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,42ME9@68525|delta/epsilon subdivisions,2WKF0@28221|Deltaproteobacteria,2MHW2@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_495610_1	1035308.AQYY01000001_gene3295	7.22e-130	392.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
k59_1200837_1	1232437.KL662031_gene2522	9.96e-36	135.0	COG1148@1|root,COG1148@2|Bacteria,1PH3R@1224|Proteobacteria,42PTD@68525|delta/epsilon subdivisions,2WIZ5@28221|Deltaproteobacteria,2MMSZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Pyr_redox_2
k59_1200837_2	706587.Desti_4264	2.28e-25	104.0	COG1148@1|root,COG1148@2|Bacteria,1PZ04@1224|Proteobacteria,42PT3@68525|delta/epsilon subdivisions,2WMJU@28221|Deltaproteobacteria,2MR5J@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	FAD dependent oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2
k59_1091320_1	1123257.AUFV01000001_gene1884	1.04e-106	321.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,1X3E0@135614|Xanthomonadales	135614|Xanthomonadales	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
k59_1020036_1	1386089.N865_04905	3.99e-24	101.0	COG0673@1|root,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria,4FENB@85021|Intrasporangiaceae	201174|Actinobacteria	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_1020036_2	1385518.N798_01560	9.23e-62	199.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2GXGF@201174|Actinobacteria,4FGQH@85021|Intrasporangiaceae	201174|Actinobacteria	M	Peptidoglycan-binding	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
k59_1375790_1	765913.ThidrDRAFT_1894	8.39e-43	147.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1WXGX@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
k59_730668_1	765912.Thimo_1399	6.44e-101	308.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WWS4@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_274379_1	2340.JV46_14220	3.69e-55	176.0	COG2703@1|root,COG2703@2|Bacteria,1N59F@1224|Proteobacteria	1224|Proteobacteria	P	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
k59_436879_1	446469.Sked_20120	7.9e-129	393.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_848062_1	706587.Desti_1112	9.61e-86	259.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WISZ@28221|Deltaproteobacteria,2MQ9P@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_98084_1	1206730.BAGA01000047_gene3858	1.5e-49	166.0	COG3836@1|root,COG3836@2|Bacteria,2HGEA@201174|Actinobacteria,4FZVX@85025|Nocardiaceae	201174|Actinobacteria	G	HpcH/HpaI aldolase/citrate lyase family	hpaI	-	4.1.2.52,4.1.2.53	ko:K02510,ko:K12660	ko00051,ko00350,ko01120,map00051,map00350,map01120	-	R01645,R01647,R02261	RC00307,RC00435,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
k59_98084_2	1381751.JAJB01000010_gene2517	1.94e-28	108.0	COG3971@1|root,COG3971@2|Bacteria,2GPBI@201174|Actinobacteria,4F8CV@85019|Brevibacteriaceae	201174|Actinobacteria	Q	hydratase	hpaH	-	-	ko:K02509	ko00350,ko01120,map00350,map01120	-	R04132,R06897	RC01615,RC02595	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
k59_319876_1	570967.JMLV01000004_gene702	7.53e-38	146.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,2JPP9@204441|Rhodospirillales	204441|Rhodospirillales	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,PAN_1,Thiol-ester_cl
k59_612918_1	118005.AWNK01000017_gene985	1.16e-80	255.0	COG4584@1|root,COG4584@2|Bacteria	2|Bacteria	L	PFAM Integrase catalytic	istA	-	-	-	-	-	-	-	-	-	-	-	rve
k59_98092_1	903818.KI912268_gene2168	8.49e-18	85.1	COG5433@1|root,COG5433@2|Bacteria	2|Bacteria	L	transposase activity	tnp4	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_848065_1	1123393.KB891326_gene42	1.52e-103	338.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2VKDG@28216|Betaproteobacteria,1KSRI@119069|Hydrogenophilales	119069|Hydrogenophilales	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
k59_1375804_1	390989.JOEG01000003_gene4552	3e-11	67.4	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4D8SX@85008|Micromonosporales	201174|Actinobacteria	V	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_202428_1	765913.ThidrDRAFT_2299	1.9e-200	592.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1WXAA@135613|Chromatiales	135613|Chromatiales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_848066_1	694431.DESACE_08570	1.18e-36	137.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42MSQ@68525|delta/epsilon subdivisions,2WISJ@28221|Deltaproteobacteria,2M691@213113|Desulfurellales	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK-1	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
k59_1499920_1	1380355.JNIJ01000094_gene274	4.25e-17	85.9	COG3509@1|root,COG3509@2|Bacteria,1MXUI@1224|Proteobacteria,2TUS5@28211|Alphaproteobacteria,3JRUS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
k59_1091346_1	886293.Sinac_0400	1.68e-66	213.0	COG4249@1|root,COG4249@2|Bacteria,2IZ2A@203682|Planctomycetes	203682|Planctomycetes	S	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_495642_1	1249627.D779_2248	9.98e-105	318.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1WXQX@135613|Chromatiales	135613|Chromatiales	L	DNA photolyase	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_392720_1	240015.ACP_2592	3.38e-78	248.0	COG0180@1|root,COG0180@2|Bacteria,3Y2VN@57723|Acidobacteria,2JHXI@204432|Acidobacteriia	204432|Acidobacteriia	J	aminoacyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_320493_2	1502724.FF80_02595	4.68e-07	50.4	COG0494@1|root,COG0494@2|Bacteria,1MZ5D@1224|Proteobacteria,2UBX9@28211|Alphaproteobacteria,3N918@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_980210_1	153948.NAL212_2974	6.69e-27	114.0	COG2911@1|root,COG2911@2|Bacteria,1N08J@1224|Proteobacteria	1224|Proteobacteria	M	Dicarboxylate transport	-	-	-	-	-	-	-	-	-	-	-	-	DctA-YdbH
k59_203134_1	550540.Fbal_1700	8.28e-56	195.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_2160,iPC815.YPO2428	B3_4,B5,FDX-ACB,tRNA_bind
k59_921097_1	1184607.AUCHE_03_01650	0.000665	40.0	2C4MW@1|root,32RKK@2|Bacteria,2IQ6A@201174|Actinobacteria,4F74G@85018|Dermatophilaceae	201174|Actinobacteria	S	Lsr2	lsr	-	-	-	-	-	-	-	-	-	-	-	Lsr2
k59_921097_2	935839.JAGJ01000020_gene102	3.98e-09	54.3	2B1V1@1|root,31UB1@2|Bacteria,2I0PK@201174|Actinobacteria,4F538@85017|Promicromonosporaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1552424_1	1118054.CAGW01000081_gene2682	6.91e-60	197.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli,26WSQ@186822|Paenibacillaceae	91061|Bacilli	C	CoA-transferase family III	-	-	2.8.3.19	ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_392734_1	1049564.TevJSym_aw00020	3.86e-147	440.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMA7@1236|Gammaproteobacteria,1J4SD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	COG0308 Aminopeptidase N	pepN	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	iECIAI1_1343.ECIAI1_0973,iECO103_1326.ECO103_0977,iECP_1309.ECP_0944,iECSE_1348.ECSE_0993,iECW_1372.ECW_m1042,iEKO11_1354.EKO11_2898,iWFL_1372.ECW_m1042	DUF3458,DUF3458_C,Peptidase_M1
k59_437589_2	177439.DP2724	1.16e-23	100.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,42MJT@68525|delta/epsilon subdivisions,2WJ7W@28221|Deltaproteobacteria,2MHNI@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_1728954_1	448385.sce4911	1.24e-38	147.0	COG1858@1|root,COG1858@2|Bacteria,1MWAT@1224|Proteobacteria,42Y6Q@68525|delta/epsilon subdivisions,2WU96@28221|Deltaproteobacteria,2YVFI@29|Myxococcales	28221|Deltaproteobacteria	C	Di-haem cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG
k59_320502_1	1049564.TevJSym_bo00090	1.69e-101	308.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,1RR3N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG2010 Cytochrome c, mono- and diheme variants	nirN	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_1020585_1	671143.DAMO_0659	7.39e-10	60.1	COG5373@1|root,COG5373@2|Bacteria	2|Bacteria	KLT	membrane	-	-	-	ko:K02451,ko:K03832	-	M00331	-	-	ko00000,ko00002,ko02000,ko02044	2.C.1.1,9.B.42	-	-	T2SSB
k59_49454_1	1042375.AFPL01000006_gene2979	1.19e-07	52.8	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,46552@72275|Alteromonadaceae	1236|Gammaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabB	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iAF1260.b2323,iAPECO1_1312.APECO1_4241,iB21_1397.B21_02208,iBWG_1329.BWG_2097,iE2348C_1286.E2348C_2463,iEC042_1314.EC042_2564,iEC55989_1330.EC55989_2567,iECABU_c1320.ECABU_c26560,iECBD_1354.ECBD_1336,iECB_1328.ECB_02248,iECDH10B_1368.ECDH10B_2485,iECDH1ME8569_1439.ECDH1ME8569_2261,iECD_1391.ECD_02248,iECED1_1282.ECED1_2787,iECIAI1_1343.ECIAI1_2400,iECIAI39_1322.ECIAI39_2472,iECNA114_1301.ECNA114_2414,iECO103_1326.ECO103_2787,iECO111_1330.ECO111_3071,iECO26_1355.ECO26_3311,iECOK1_1307.ECOK1_2605,iECP_1309.ECP_2362,iECS88_1305.ECS88_2471,iECSE_1348.ECSE_2632,iECSF_1327.ECSF_2200,iECUMN_1333.ECUMN_2663,iECW_1372.ECW_m2512,iEKO11_1354.EKO11_1442,iETEC_1333.ETEC_2459,iEcDH1_1363.EcDH1_1333,iEcHS_1320.EcHS_A2474,iEcSMS35_1347.EcSMS35_2480,iEcolC_1368.EcolC_1329,iJN746.PP_4175,iJO1366.b2323,iJR904.b2323,iLF82_1304.LF82_0605,iNRG857_1313.NRG857_11765,iSBO_1134.SBO_2360,iUMN146_1321.UM146_05195,iUTI89_1310.UTI89_C2608,iWFL_1372.ECW_m2512,iY75_1357.Y75_RS12180,ic_1306.c2869	Ketoacyl-synt_C,ketoacyl-synt
k59_49454_2	469383.Cwoe_4226	3.18e-219	622.0	COG2303@1|root,COG2303@2|Bacteria,2GJ3J@201174|Actinobacteria,4CRRH@84995|Rubrobacteria	84995|Rubrobacteria	E	GMC oxidoreductase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_149609_1	666685.R2APBS1_0795	2.18e-153	442.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,1RMP0@1236|Gammaproteobacteria,1X4KU@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1506290_1	1267005.KB911258_gene96	2.05e-56	181.0	COG4964@1|root,COG4964@2|Bacteria,1R3QI@1224|Proteobacteria,2UGFC@28211|Alphaproteobacteria,3N93Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Pilus formation protein N terminal region	pilQ	-	-	-	-	-	-	-	-	-	-	-	T2SS-T3SS_pil_N
k59_559699_1	1415778.JQMM01000001_gene1581	5.02e-97	295.0	COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,1J56D@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,DUF3335
k59_49480_1	96561.Dole_0978	1.74e-67	225.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,42N15@68525|delta/epsilon subdivisions,2WJ0Y@28221|Deltaproteobacteria,2MHMT@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM Carbamoyltransferase	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
k59_208130_1	555079.Toce_0276	6.85e-59	192.0	COG0521@1|root,COG2258@1|root,COG0521@2|Bacteria,COG2258@2|Bacteria,1V3XM@1239|Firmicutes,24HG2@186801|Clostridia,42G8D@68295|Thermoanaerobacterales	186801|Clostridia	H	TIGRFAM molybdenum cofactor synthesis domain	mog	-	-	-	-	-	-	-	-	-	-	-	MOSC,MoCF_biosynth
k59_559702_1	765912.Thimo_0947	1.4e-48	164.0	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,1RMP3@1236|Gammaproteobacteria,1WWKK@135613|Chromatiales	135613|Chromatiales	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
k59_559702_2	1049564.TevJSym_ak00310	2.3e-77	238.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,1J5CU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0016783,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
k59_1024672_2	419947.MRA_1573	2.27e-22	92.8	COG1487@1|root,COG1487@2|Bacteria,2ISE2@201174|Actinobacteria,23B4F@1762|Mycobacteriaceae	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0040008,GO:0043170,GO:0043207,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0045926,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0071704,GO:0075136,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113	-	-	-	-	-	-	-	-	-	-	PIN
k59_1024672_4	1120797.KB908270_gene2918	2.02e-28	106.0	COG3654@1|root,COG3654@2|Bacteria,2IR34@201174|Actinobacteria,239VE@1762|Mycobacteriaceae	201174|Actinobacteria	S	Death-on-curing protein	doc	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
k59_790353_1	471853.Bcav_1102	8.97e-112	330.0	COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria	201174|Actinobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
k59_1616286_1	670292.JH26_17795	9.68e-91	275.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,1JRED@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	PFAM Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_108535_1	1049564.TevJSym_ae00910	2.58e-77	243.0	COG0477@1|root,COG2814@2|Bacteria,1MV8D@1224|Proteobacteria,1RNF0@1236|Gammaproteobacteria,1J4TF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1677241_1	640081.Dsui_1126	7.48e-40	150.0	COG4206@1|root,COG4206@2|Bacteria,1N71E@1224|Proteobacteria,2VJZ9@28216|Betaproteobacteria	28216|Betaproteobacteria	H	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_989600_1	385682.AFSL01000063_gene1561	4.54e-21	97.1	COG3014@1|root,COG3014@2|Bacteria,4NIIU@976|Bacteroidetes,2FQVB@200643|Bacteroidia,3XJT4@558415|Marinilabiliaceae	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	ko:K09859	-	-	-	-	ko00000	-	-	-	TPR_2
k59_108544_1	471853.Bcav_3173	2.35e-109	325.0	COG1816@1|root,COG1816@2|Bacteria,2GKJP@201174|Actinobacteria	201174|Actinobacteria	F	Adenosine deaminase	add	GO:0000034,GO:0003674,GO:0003824,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046083,GO:0046100,GO:0046101,GO:0046112,GO:0046113,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
k59_619100_1	313628.LNTAR_13952	1.02e-17	83.2	COG0497@1|root,COG0497@2|Bacteria	2|Bacteria	L	DNA recombination	recN	-	-	ko:K03631,ko:K07459	-	-	-	-	ko00000,ko03400	-	-	-	AAA_15,SMC_N
k59_1272875_1	314345.SPV1_13202	3.96e-90	276.0	COG0531@1|root,COG0531@2|Bacteria,1QXK2@1224|Proteobacteria	1224|Proteobacteria	E	amino acid	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	AA_permease_2
k59_208939_1	1193181.BN10_770001	1.06e-94	286.0	COG0861@1|root,COG0861@2|Bacteria,2GIWU@201174|Actinobacteria,4FEUG@85021|Intrasporangiaceae	201174|Actinobacteria	P	Tellurium resistance protein TerC	terC	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
k59_560481_1	1187848.AJYQ01000004_gene194	5.18e-07	55.8	COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,1RPHW@1236|Gammaproteobacteria,1XVMH@135623|Vibrionales	135623|Vibrionales	M	Male sterility protein	galE-1	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_930425_1	439496.RBY4I_2914	7.85e-32	121.0	COG1715@1|root,COG1715@2|Bacteria,1Q2VY@1224|Proteobacteria,2TVMP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	restriction endonuclease	mrr	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	Mrr_N,Mrr_cat
k59_1677265_1	1121405.dsmv_1696	2.64e-80	258.0	COG4581@1|root,COG4581@2|Bacteria,1QUPR@1224|Proteobacteria,42NSH@68525|delta/epsilon subdivisions,2WKD7@28221|Deltaproteobacteria,2MHX7@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DEAD DEAH box helicase	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,DSHCT,DUF3516,Helicase_C
k59_443250_1	1122933.JNIY01000003_gene1068	1.65e-48	166.0	COG0765@1|root,COG0765@2|Bacteria,2GNBH@201174|Actinobacteria,4F29Z@85016|Cellulomonadaceae	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	gluD	-	-	ko:K10007	ko02010,map02010	M00233	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.9	-	-	BPD_transp_1
k59_1870080_2	443144.GM21_2024	1.2e-15	79.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2WMQK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
k59_1144030_1	1051632.TPY_0663	3.55e-62	210.0	COG1331@1|root,COG1331@2|Bacteria,1TPRD@1239|Firmicutes,248PD@186801|Clostridia	186801|Clostridia	O	Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_1382302_1	1049564.TevJSym_ad00280	2.42e-91	284.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1J4U3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CP	CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	-	-	1.6.5.3	ko:K05577	ko00190,ko01100,map00190,map01100	M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	-	-	-	Proton_antipo_M,Proton_antipo_N
k59_50737_1	864069.MicloDRAFT_00015940	2.63e-40	147.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2U3ZY@28211|Alphaproteobacteria,1JZ61@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_1144034_1	1121035.AUCH01000015_gene2504	2.65e-34	130.0	COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,2VQGZ@28216|Betaproteobacteria,2KYI0@206389|Rhodocyclales	206389|Rhodocyclales	PT	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,cNMP_binding
k59_283423_1	314278.NB231_03817	1.48e-93	297.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM NADH-quinone oxidoreductase, chain G	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1442295_1	1227261.HMPREF0043_00252	4.57e-62	210.0	COG1640@1|root,COG1640@2|Bacteria,2GM5Z@201174|Actinobacteria,4D33D@85005|Actinomycetales	201174|Actinobacteria	G	4-alpha-glucanotransferase	malQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_326177_1	1415780.JPOG01000001_gene894	2.25e-54	183.0	COG0108@1|root,COG0108@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1X31N@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_108582_1	1304885.AUEY01000002_gene357	8.12e-44	159.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WK44@28221|Deltaproteobacteria,2MJ5Q@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	MFS_1,OEP
k59_1025305_2	1120934.KB894416_gene4090	1.44e-96	289.0	COG0656@1|root,COG0656@2|Bacteria,2GJQ7@201174|Actinobacteria,4DZ9X@85010|Pseudonocardiales	201174|Actinobacteria	S	Aldo keto	-	-	1.1.1.346	ko:K06221	-	-	R08878	RC00089	ko00000,ko01000	-	-	-	Aldo_ket_red
k59_208964_1	626887.J057_10366	2.37e-25	105.0	COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,1SEJ8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_208964_2	1265505.ATUG01000002_gene1779	6.52e-16	77.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria,2MIT8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_854346_1	1049564.TevJSym_bt00080	1.55e-63	202.0	COG2834@1|root,COG2834@2|Bacteria,1R5U8@1224|Proteobacteria	1224|Proteobacteria	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
k59_560509_1	768671.ThimaDRAFT_1381	4.13e-122	361.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1WX79@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
k59_1558099_1	879212.DespoDRAFT_00150	1.23e-11	65.1	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42TZ6@68525|delta/epsilon subdivisions,2WQY3@28221|Deltaproteobacteria,2MN04@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_443268_1	519989.ECTPHS_01899	1.34e-53	181.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1WVUV@135613|Chromatiales	135613|Chromatiales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_108590_2	483219.LILAB_01375	2.88e-91	290.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,42M40@68525|delta/epsilon subdivisions,2WIM4@28221|Deltaproteobacteria,2YUC0@29|Myxococcales	28221|Deltaproteobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_1207139_1	675635.Psed_6853	2e-06	47.4	COG3439@1|root,COG3439@2|Bacteria,2IKVF@201174|Actinobacteria,4E4ZR@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_1207139_2	2045.KR76_02635	1.24e-175	498.0	COG0598@1|root,COG0598@2|Bacteria,2GKNZ@201174|Actinobacteria,4DPRY@85009|Propionibacteriales	201174|Actinobacteria	P	CorA-like Mg2+ transporter protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_108602_1	2340.JV46_18390	9.58e-94	297.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1J4J1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Cytochrome c-type biogenesis protein	ccmF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_1677303_1	1396141.BATP01000020_gene55	1.01e-07	58.9	COG2304@1|root,COG2304@2|Bacteria,46VTY@74201|Verrucomicrobia	2|Bacteria	G	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,FG-GAP_2,FctA,VWA,VWA_2
k59_108608_1	643867.Ftrac_1087	0.000232	46.6	COG0616@1|root,COG0616@2|Bacteria,4NES1@976|Bacteroidetes,47KQH@768503|Cytophagia	976|Bacteroidetes	OU	signal peptide peptidase SppA, 36K type	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_108608_2	717774.Marme_1286	4.9e-27	107.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RMNY@1236|Gammaproteobacteria,1XIGQ@135619|Oceanospirillales	135619|Oceanospirillales	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_501928_1	1218352.B597_010240	7.91e-29	110.0	COG3133@1|root,COG3133@2|Bacteria,1RA1D@1224|Proteobacteria,1S8SF@1236|Gammaproteobacteria,1Z0MR@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	M	COG3133 Outer membrane lipoprotein	-	-	-	ko:K06077	-	-	-	-	ko00000	-	-	-	Rick_17kDa_Anti
k59_1382343_1	1121405.dsmv_3691	6.08e-95	289.0	COG3547@1|root,COG3547@2|Bacteria,1NP2U@1224|Proteobacteria,43A5Q@68525|delta/epsilon subdivisions,2X2AM@28221|Deltaproteobacteria,2MPDW@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1025332_1	1282876.BAOK01000001_gene2255	4.68e-121	355.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2TS3R@28211|Alphaproteobacteria,4BPBB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_619158_1	1035308.AQYY01000001_gene1922	3.8e-118	342.0	COG0692@1|root,COG0692@2|Bacteria,1TPSN@1239|Firmicutes,247N9@186801|Clostridia,261C6@186807|Peptococcaceae	186801|Clostridia	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine	ung	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_1144068_1	589865.DaAHT2_0484	5.14e-34	131.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42N7X@68525|delta/epsilon subdivisions,2WMM9@28221|Deltaproteobacteria,2MMU3@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1616372_1	177437.HRM2_15530	6.01e-82	259.0	COG0668@1|root,COG3064@1|root,COG0668@2|Bacteria,COG3064@2|Bacteria,1N596@1224|Proteobacteria,42Z9C@68525|delta/epsilon subdivisions,2WUFQ@28221|Deltaproteobacteria,2MN3G@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel
k59_854371_1	933262.AXAM01000004_gene2371	1.36e-93	289.0	28I62@1|root,2Z896@2|Bacteria,1MWB8@1224|Proteobacteria,42P7E@68525|delta/epsilon subdivisions,2WKM1@28221|Deltaproteobacteria,2MIBX@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1616375_1	595460.RRSWK_04629	1.13e-100	306.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1,Glycos_transf_2
k59_1870142_2	1430440.MGMSRv2_4143	1.41e-34	125.0	COG0454@1|root,COG0456@2|Bacteria,1NCNY@1224|Proteobacteria,2UF7T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_560543_1	1173021.ALWA01000031_gene2823	1.15e-25	103.0	COG1064@1|root,COG1064@2|Bacteria,1G327@1117|Cyanobacteria	1117|Cyanobacteria	S	Zinc-binding alcohol dehydrogenase family protein	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_283467_1	367299.JOEE01000004_gene1002	2.35e-158	455.0	COG0055@1|root,COG0055@2|Bacteria,2GIY6@201174|Actinobacteria,4FE4V@85021|Intrasporangiaceae	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1870145_2	472759.Nhal_2557	1.13e-41	146.0	COG1295@1|root,COG1295@2|Bacteria,1NH82@1224|Proteobacteria,1S3T8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ribonuclease BN	-	-	-	-	-	-	-	-	-	-	-	-	Virul_fac_BrkB
k59_1144079_1	640081.Dsui_2884	4.84e-38	135.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,2VR4C@28216|Betaproteobacteria,2KW6V@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	-	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
k59_737479_1	326442.PSHAa0856	7e-53	183.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,1RNH4@1236|Gammaproteobacteria,2Q05M@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	ybaL	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
k59_1144085_2	1304865.JAGF01000001_gene3580	7.53e-37	134.0	COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria,4F1QP@85016|Cellulomonadaceae	201174|Actinobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
k59_1442358_2	648757.Rvan_0470	1.12e-15	78.2	COG1596@1|root,COG1596@2|Bacteria,1RE48@1224|Proteobacteria,2U75D@28211|Alphaproteobacteria,3N8F3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	polysaccharide export	gumB	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
k59_989732_1	367299.JOEE01000010_gene3315	8.75e-149	428.0	COG0174@1|root,COG0174@2|Bacteria,2GJ2I@201174|Actinobacteria,4FF3Q@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the glutamine synthetase family	glnA2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_1677334_1	1449347.JQLN01000006_gene2646	4e-103	311.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,2M0B7@2063|Kitasatospora	201174|Actinobacteria	S	Reductase C-terminal	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
k59_1677334_2	298653.Franean1_4344	6.1e-57	184.0	2B3JS@1|root,31W90@2|Bacteria,2GP1G@201174|Actinobacteria,4ETB0@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1677334_3	1385519.N801_03195	2.81e-58	195.0	COG2234@1|root,COG2234@2|Bacteria,2IDP0@201174|Actinobacteria,4FE57@85021|Intrasporangiaceae	201174|Actinobacteria	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_989734_1	1347342.BN863_27680	2.61e-13	74.7	COG3137@1|root,COG3137@2|Bacteria,4PPYQ@976|Bacteroidetes,1HZDK@117743|Flavobacteriia	976|Bacteroidetes	M	Protein of unknown function, DUF481	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
k59_619192_1	95619.PM1_0210870	3.26e-59	191.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7,3.1.26.4	ko:K02342,ko:K14159	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_H,RNase_T
k59_1144096_1	526226.Gbro_2688	1.41e-21	94.4	COG1708@1|root,COG1708@2|Bacteria,2IPHD@201174|Actinobacteria,4GBWX@85026|Gordoniaceae	201174|Actinobacteria	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
k59_989744_1	697282.Mettu_2523	1.96e-112	348.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1XEJP@135618|Methylococcales	135618|Methylococcales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_150552_1	1304865.JAGF01000001_gene1528	4.18e-77	243.0	COG5002@1|root,COG5002@2|Bacteria,2I3U8@201174|Actinobacteria	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_501977_1	472759.Nhal_1172	5.75e-07	48.1	COG0011@1|root,COG0011@2|Bacteria,1N1NM@1224|Proteobacteria,1SAV8@1236|Gammaproteobacteria,1WZPV@135613|Chromatiales	135613|Chromatiales	S	Thiamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
k59_1677344_1	1158292.JPOE01000002_gene2981	6.67e-62	199.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2VJK6@28216|Betaproteobacteria,1KKGZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	ATPases associated with a variety of cellular activities	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_1207207_1	1234364.AMSF01000055_gene1029	3.83e-13	75.1	COG4223@1|root,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,1RYCQ@1236|Gammaproteobacteria,1XDAZ@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1631)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631
k59_859503_1	640511.BC1002_6328	9.03e-44	145.0	COG1006@1|root,COG1006@2|Bacteria	2|Bacteria	P	Multisubunit Na H antiporter MnhC subunit	-	-	-	ko:K05560,ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
k59_156184_1	1049564.TevJSym_ai00210	6.61e-116	351.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1J4VX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_938285_1	641526.ADIWIN_1176	6.42e-98	302.0	COG0366@1|root,COG0366@2|Bacteria,4NGC8@976|Bacteroidetes,1HWR1@117743|Flavobacteriia	976|Bacteroidetes	G	Alpha-amylase domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
k59_1349985_1	585531.HMPREF0063_12970	2.8e-79	246.0	COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria,4DN1G@85009|Propionibacteriales	201174|Actinobacteria	F	IMP dehydrogenase / GMP reductase domain	guaB3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	IMPDH
k59_1682525_1	1396141.BATP01000020_gene17	7.39e-66	209.0	COG4313@1|root,COG4313@2|Bacteria,46UHV@74201|Verrucomicrobia,2IVEU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
k59_997525_2	745411.B3C1_04685	1.41e-68	217.0	COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,1J6CU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Belongs to the DnaA family. HdA subfamily	hda	GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113	-	ko:K10763	-	-	-	-	ko00000,ko03032	-	-	-	Bac_DnaA
k59_997525_4	1158756.AQXQ01000009_gene1040	2.26e-25	99.8	COG3308@1|root,COG3308@2|Bacteria,1N5UB@1224|Proteobacteria,1SAAJ@1236|Gammaproteobacteria,1X1QR@135613|Chromatiales	135613|Chromatiales	S	Predicted membrane protein (DUF2069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2069
k59_997525_5	572477.Alvin_1633	1.3e-97	288.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,1S23B@1236|Gammaproteobacteria,1WW1Q@135613|Chromatiales	135613|Chromatiales	S	Belongs to the WrbA family	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
k59_624729_2	765912.Thimo_2530	6.21e-58	192.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1WW0B@135613|Chromatiales	135613|Chromatiales	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_684446_1	397278.JOJN01000029_gene956	2.88e-91	275.0	COG2801@1|root,COG2801@2|Bacteria,2GJ3V@201174|Actinobacteria,4DUKR@85009|Propionibacteriales	201174|Actinobacteria	L	Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	LZ_Tnp_IS481,rve,rve_3
k59_331990_1	1191523.MROS_2293	5.97e-78	252.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria	2|Bacteria	F	GMP synthase (glutamine-hydrolyzing) activity	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.3.1.128,6.3.5.2	ko:K01951,ko:K03790	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002,ko03009	-	-	iJN746.PP_1032,iLJ478.TM1820,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833	GATase,GMP_synt_C,NAD_synthase
k59_214509_1	1122604.JONR01000001_gene2003	1.32e-31	123.0	COG3719@1|root,COG3719@2|Bacteria,1PTUN@1224|Proteobacteria,1S7WD@1236|Gammaproteobacteria,1X79Y@135614|Xanthomonadales	135614|Xanthomonadales	J	Ribonuclease T2 family	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuclease_T2
k59_214509_2	314345.SPV1_00647	6.01e-15	74.3	COG0803@1|root,COG0803@2|Bacteria,1PQEX@1224|Proteobacteria	1224|Proteobacteria	P	Periplasmic solute binding protein	znuA	-	-	ko:K02077	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
k59_1513084_1	196162.Noca_0159	2.97e-40	144.0	COG1672@1|root,COG1672@2|Bacteria,2GWBV@201174|Actinobacteria,4DNB8@85009|Propionibacteriales	201174|Actinobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
k59_1513084_3	471852.Tcur_0697	3.26e-50	172.0	COG0588@1|root,COG0588@2|Bacteria,2GK8F@201174|Actinobacteria,4EFVY@85012|Streptosporangiales	201174|Actinobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031323,GO:0031329,GO:0032787,GO:0032991,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
k59_410182_1	590998.Celf_1839	7.41e-85	275.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4F28A@85016|Cellulomonadaceae	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_57960_2	1117647.M5M_05690	2.72e-18	81.6	COG3637@1|root,COG3637@2|Bacteria,1PES3@1224|Proteobacteria,1RWRV@1236|Gammaproteobacteria,1J77C@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	OmpA-like transmembrane domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
k59_1278926_1	224911.27352647	0.000931	42.0	COG0834@1|root,COG0834@2|Bacteria,1MVBK@1224|Proteobacteria,2U0E1@28211|Alphaproteobacteria,3JWI3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K10001	ko02010,ko02020,map02010,map02020	M00230	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.19,3.A.1.3.4	-	-	SBP_bac_3
k59_859523_1	1267005.KB911256_gene1877	6.56e-64	216.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2TTA4@28211|Alphaproteobacteria,3N7PS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	yjcG	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_859523_2	1187851.A33M_1117	7.45e-40	136.0	COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,2U945@28211|Alphaproteobacteria,3FEFX@34008|Rhodovulum	28211|Alphaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
k59_1212346_1	95619.PM1_0225625	1.23e-22	98.2	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Lipoprotein releasing system transmembrane protein	lolE	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_1513097_1	644282.Deba_1805	4.13e-92	279.0	COG0845@1|root,COG0845@2|Bacteria,1MV1R@1224|Proteobacteria,42PEF@68525|delta/epsilon subdivisions,2WJ93@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_1740305_1	521393.JH806632_gene67	8.16e-135	404.0	COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,4D36J@85005|Actinomycetales	201174|Actinobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1563622_1	631362.Thi970DRAFT_03691	2.79e-40	146.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,1RQGG@1236|Gammaproteobacteria,1WW8R@135613|Chromatiales	135613|Chromatiales	C	Seven times multi-haem cytochrome CxxCH	-	-	1.7.2.6	ko:K10535	ko00910,ko01120,map00910,map01120	M00528,M00804	R10164	RC00383	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrome_C554,Multi-haem_cyto
k59_1563622_2	765911.Thivi_1284	1.2e-40	140.0	COG3005@1|root,COG3005@2|Bacteria,1NI00@1224|Proteobacteria,1S16Q@1236|Gammaproteobacteria,1WWYE@135613|Chromatiales	135613|Chromatiales	C	PFAM NapC NirT cytochrome c	-	-	-	ko:K03532	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	5.A.3.4	-	-	Cytochrom_NNT
k59_507605_1	1198452.Jab_2c32980	3.25e-52	184.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria,4728K@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Ferrous iron transport protein B C terminus	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_1447573_1	1449350.OCH239_20365	9.13e-53	178.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TTAW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_624768_1	713587.THITH_14335	1.44e-55	177.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1WXDE@135613|Chromatiales	135613|Chromatiales	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_1350045_1	367299.JOEE01000005_gene3515	9.8e-44	152.0	COG0682@1|root,COG0682@2|Bacteria,2GKSS@201174|Actinobacteria,4FFGE@85021|Intrasporangiaceae	201174|Actinobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	-	-	-	-	-	-	-	-	-	LGT
k59_410228_1	234267.Acid_7147	1.87e-134	389.0	COG0714@1|root,COG0714@2|Bacteria,3Y6Z3@57723|Acidobacteria	57723|Acidobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
k59_156240_1	555779.Dthio_PD2250	3.77e-71	228.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,42R8Z@68525|delta/epsilon subdivisions,2WMXX@28221|Deltaproteobacteria,2MAE4@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin,cNMP_binding
k59_1682574_1	101510.RHA1_ro00462	1.24e-12	75.1	COG3328@1|root,COG3666@1|root,COG3328@2|Bacteria,COG3666@2|Bacteria,2HW2F@201174|Actinobacteria,4G8FB@85025|Nocardiaceae	201174|Actinobacteria	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_794837_1	1267005.KB911255_gene2940	3.28e-118	375.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3N644@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC	MA20_18100	-	3.1.4.52	ko:K13245	ko04112,map04112	-	R08991	RC00296	ko00000,ko00001,ko01000	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,EAL,GGDEF,PAS_3
k59_859556_1	1415778.JQMM01000001_gene2181	2.22e-245	684.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1J5DU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA1	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_214546_1	880072.Desac_2420	6.86e-88	289.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MQ8R@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
k59_1740321_1	1121405.dsmv_2161	8.5e-90	279.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2MHPV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1683463_1	930166.CD58_23035	1.14e-32	125.0	COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,1RNCG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Metal-dependent phosphoesterases (PHP family)	trpH	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004534,GO:0004536,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006521,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008409,GO:0009987,GO:0010565,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016796,GO:0016895,GO:0016896,GO:0019222,GO:0030145,GO:0031323,GO:0033238,GO:0034641,GO:0035312,GO:0042578,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090357,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
k59_1741264_1	518766.Rmar_0337	2.87e-15	78.6	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,4NEP3@976|Bacteroidetes,1FIWT@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Pyruvate:ferredoxin oxidoreductase core domain II	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_1741264_2	1049564.TevJSym_bb00040	2.73e-18	83.6	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,1RZ7Y@1236|Gammaproteobacteria,1J5GQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_567047_2	446469.Sked_36290	2.91e-40	135.0	COG0776@1|root,COG0776@2|Bacteria,2IKQR@201174|Actinobacteria	201174|Actinobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_625716_1	338963.Pcar_0058	4.33e-80	248.0	COG3640@1|root,COG3640@2|Bacteria,1RB02@1224|Proteobacteria,42NBP@68525|delta/epsilon subdivisions,2WKS7@28221|Deltaproteobacteria,43TD8@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Anion-transporting ATPase	cooC	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
k59_508496_1	367299.JOEE01000002_gene2465	5.9e-47	153.0	COG1196@1|root,COG1196@2|Bacteria,2IMXX@201174|Actinobacteria,4FHC2@85021|Intrasporangiaceae	201174|Actinobacteria	D	Protein of unknown function (DUF4446)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4446
k59_508496_2	367299.JOEE01000002_gene2464	3.52e-50	168.0	COG0077@1|root,COG0077@2|Bacteria,2GJQ5@201174|Actinobacteria,4FG1M@85021|Intrasporangiaceae	201174|Actinobacteria	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
k59_567048_2	1454010.JEOE01000019_gene2349	1.03e-18	84.0	COG0356@1|root,COG0356@2|Bacteria,2H3PR@201174|Actinobacteria,4F0IJ@85016|Cellulomonadaceae	201174|Actinobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_157086_1	439235.Dalk_3615	2.88e-105	322.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2MJ2X@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_795527_1	2340.JV46_24740	2.15e-96	293.0	COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,1RXX2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative metallopeptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2201,DUF2201_N
k59_1032527_1	1049564.TevJSym_by00060	1.76e-19	81.3	2E7PJ@1|root,33255@2|Bacteria,1NANJ@1224|Proteobacteria,1SDCV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1032527_2	292415.Tbd_1502	2.52e-76	239.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria,1KRDF@119069|Hydrogenophilales	119069|Hydrogenophilales	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_1741287_1	713586.KB900536_gene454	1.2e-104	308.0	COG1011@1|root,COG1011@2|Bacteria,1MVWN@1224|Proteobacteria,1RR0H@1236|Gammaproteobacteria,1X0PW@135613|Chromatiales	135613|Chromatiales	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_332943_1	1267005.KB911255_gene2597	9.57e-09	55.5	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2TRUF@28211|Alphaproteobacteria,3N69P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_332943_2	670307.HYPDE_40798	1.57e-98	290.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,2TRMC@28211|Alphaproteobacteria,3N6E9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
k59_449817_1	1396141.BATP01000028_gene2309	2.32e-73	231.0	COG0002@1|root,COG0002@2|Bacteria,46SA3@74201|Verrucomicrobia,2IU18@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Semialdehyde dehydrogenase, NAD binding domain	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_744009_1	1172185.KB911533_gene34	8.65e-21	87.8	2E1KM@1|root,32WY3@2|Bacteria,2GUNE@201174|Actinobacteria	201174|Actinobacteria	S	Methylmuconolactone methyl-isomerase	-	-	-	-	-	-	-	-	-	-	-	-	EthD
k59_1032536_1	631362.Thi970DRAFT_04738	1.79e-48	171.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1RMA2@1236|Gammaproteobacteria,1WXJP@135613|Chromatiales	135613|Chromatiales	M	PFAM glycosyl transferase family 39	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_1448493_1	1268635.Loa_02345	1.46e-114	338.0	COG3039@1|root,COG3039@2|Bacteria,1Q9AW@1224|Proteobacteria,1RNU1@1236|Gammaproteobacteria,1JEXN@118969|Legionellales	118969|Legionellales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_3
k59_1388690_2	572477.Alvin_0107	4.66e-29	110.0	2B7TJ@1|root,32102@2|Bacteria,1RHKS@1224|Proteobacteria,1S7PY@1236|Gammaproteobacteria,1WYNN@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF5063)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5063
k59_292094_1	96561.Dole_2486	5.2e-31	114.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,42M39@68525|delta/epsilon subdivisions,2WJEZ@28221|Deltaproteobacteria,2MI50@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
k59_292094_2	187272.Mlg_1363	2e-08	55.5	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,1WXKW@135613|Chromatiales	135613|Chromatiales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_685322_1	1304865.JAGF01000001_gene3939	1.44e-136	397.0	COG1732@1|root,COG1732@2|Bacteria,2GJWY@201174|Actinobacteria,4F1HX@85016|Cellulomonadaceae	201174|Actinobacteria	M	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
k59_685322_2	1095767.CAHD01000234_gene2791	9.13e-69	217.0	COG1174@1|root,COG1174@2|Bacteria,2GYTC@201174|Actinobacteria,4F2D4@85016|Cellulomonadaceae	201174|Actinobacteria	E	PFAM binding-protein-dependent transport systems inner membrane component	proW	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
k59_292105_1	1380354.JIAN01000007_gene89	2.23e-110	333.0	COG2262@1|root,COG2262@2|Bacteria,2GK55@201174|Actinobacteria,4F0W2@85016|Cellulomonadaceae	201174|Actinobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_1105537_1	1123518.ARWI01000001_gene1058	1.58e-119	356.0	COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,1RQJ4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the Orn Lys Arg decarboxylase class-II family	speC	-	4.1.1.17,4.1.1.20	ko:K01581,ko:K01586	ko00300,ko00330,ko00480,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map00330,map00480,map01100,map01110,map01120,map01130,map01230	M00016,M00134,M00525,M00526,M00527	R00451,R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_0864	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_1448502_2	522306.CAP2UW1_4329	3.28e-34	123.0	COG3917@1|root,COG3917@2|Bacteria,1RDNQ@1224|Proteobacteria,2VQJ1@28216|Betaproteobacteria,1KQTA@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	Q	DSBA-like thioredoxin domain	-	-	5.99.1.4	ko:K14584	ko00626,ko01100,ko01120,ko01220,map00626,map01100,map01120,map01220	M00534	R05137	RC03084	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	DSBA
k59_625762_2	314345.SPV1_03033	1.99e-50	167.0	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria	1224|Proteobacteria	T	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
k59_1564473_1	1209984.BN978_04824	1.65e-136	412.0	COG3497@1|root,COG3497@2|Bacteria,2GMJA@201174|Actinobacteria,2386C@1762|Mycobacteriaceae	201174|Actinobacteria	S	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
k59_1279976_1	631454.N177_2502	2.97e-32	124.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria,1JNJQ@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1105550_1	1463858.JOHR01000001_gene6365	8.2e-07	53.9	COG3424@1|root,COG3424@2|Bacteria,2GV0U@201174|Actinobacteria	201174|Actinobacteria	Q	synthase	pks11	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006629,GO:0006725,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009698,GO:0009699,GO:0009714,GO:0009715,GO:0009987,GO:0016020,GO:0016043,GO:0019438,GO:0019748,GO:0022607,GO:0032991,GO:0034081,GO:0042180,GO:0042181,GO:0042546,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:1901360,GO:1901362,GO:1901576	-	ko:K16167	-	-	-	-	ko00000,ko01008	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
k59_567100_1	1122132.AQYH01000005_gene632	1.18e-51	171.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2TV3J@28211|Alphaproteobacteria,4B7PK@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
k59_1448515_1	765911.Thivi_4194	3.21e-99	322.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_508550_1	335543.Sfum_2759	4.48e-145	421.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2WJ7H@28221|Deltaproteobacteria,2MQ82@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC,GARS_A,GARS_C,GARS_N
k59_157136_1	472759.Nhal_1481	1.33e-65	214.0	COG2403@1|root,COG2403@2|Bacteria,1MV4C@1224|Proteobacteria	1224|Proteobacteria	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_157136_2	472759.Nhal_1480	2.01e-13	69.7	COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,1RP78@1236|Gammaproteobacteria,1X09I@135613|Chromatiales	135613|Chromatiales	E	Amino acid kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_1032578_1	1095767.CAHD01000235_gene2859	1.23e-45	166.0	COG5549@1|root,COG5549@2|Bacteria,2IJMT@201174|Actinobacteria	201174|Actinobacteria	O	PFAM peptidase M10A and M12B, matrixin and adamalysin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
k59_1683525_2	1485544.JQKP01000005_gene328	8.19e-10	57.0	2A8Y3@1|root,30Y1Q@2|Bacteria,1PJWW@1224|Proteobacteria,2W88P@28216|Betaproteobacteria,44WJJ@713636|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_567106_2	666685.R2APBS1_2752	1.83e-37	131.0	2E31J@1|root,32Y1Y@2|Bacteria,1N745@1224|Proteobacteria,1SCMM@1236|Gammaproteobacteria,1X8QA@135614|Xanthomonadales	135614|Xanthomonadales	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
k59_1388721_1	335543.Sfum_3649	6.81e-233	654.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2WIZQ@28221|Deltaproteobacteria,2MQZI@213462|Syntrophobacterales	28221|Deltaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_1797065_1	768671.ThimaDRAFT_0728	7.23e-38	131.0	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,1S2ZH@1236|Gammaproteobacteria,1WXZY@135613|Chromatiales	135613|Chromatiales	S	Sulfur oxidation protein SoxY	-	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY
k59_1683533_1	331678.Cphamn1_1145	2.16e-21	95.1	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	int	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_1458806_5	446466.Cfla_0126	7.11e-29	115.0	2DR5D@1|root,33A8R@2|Bacteria,2HXX5@201174|Actinobacteria,4F1HD@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2993)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2993
k59_1458806_6	471853.Bcav_3955	3.47e-134	403.0	COG1276@1|root,COG3336@1|root,COG1276@2|Bacteria,COG3336@2|Bacteria,2GKIR@201174|Actinobacteria	201174|Actinobacteria	P	Cytochrome c oxidase	-	-	-	ko:K02351,ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	Caa3_CtaG,CopD
k59_1158271_1	713587.THITH_02075	3.64e-12	67.8	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRR1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1158271_2	388399.SSE37_03275	2.53e-07	51.2	COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,2TUHN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type tungstate transport system, periplasmic component	-	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
k59_1526223_1	396588.Tgr7_0853	1.06e-73	228.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria	1224|Proteobacteria	C	Thiosulfate-oxidizing multienzyme system protein SoxA	-	-	1.8.2.2	ko:K17222,ko:K19713	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	-	-	-	-
k59_1458820_1	367299.JOEE01000005_gene3493	9.68e-104	305.0	COG3201@1|root,COG3201@2|Bacteria,2GMBT@201174|Actinobacteria,4FFX0@85021|Intrasporangiaceae	201174|Actinobacteria	H	Nicotinamide mononucleotide transporter	pnuC	-	-	ko:K03811	-	-	-	-	ko00000,ko02000	4.B.1.1	-	-	NMN_transporter
k59_753926_1	572477.Alvin_1175	1.94e-06	49.3	COG4659@1|root,COG4659@2|Bacteria,1R6FE@1224|Proteobacteria,1RYZ7@1236|Gammaproteobacteria,1WXWE@135613|Chromatiales	135613|Chromatiales	U	Part of a membrane complex involved in electron transport	-	-	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
k59_753926_2	765911.Thivi_3184	1.43e-106	313.0	COG4660@1|root,COG4660@2|Bacteria,1R342@1224|Proteobacteria,1T62W@1236|Gammaproteobacteria,1WW5Q@135613|Chromatiales	135613|Chromatiales	U	Part of a membrane complex involved in electron transport	-	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
k59_458441_1	293826.Amet_0047	4.15e-27	110.0	COG0476@1|root,COG0476@2|Bacteria,1TQ3U@1239|Firmicutes,25CJC@186801|Clostridia,36GDP@31979|Clostridiaceae	186801|Clostridia	H	UBA THIF-type NAD FAD binding protein	moeB	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
k59_1693774_1	1049564.TevJSym_ag00670	9.94e-161	454.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,1RN7C@1236|Gammaproteobacteria,1JB5W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	CbbQ/NirQ/NorQ C-terminal	norQ	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
k59_1693774_2	177439.DP0011	5.88e-09	57.4	2EZKA@1|root,33SRC@2|Bacteria,1NSR5@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1750569_1	1488328.JMCL01000030_gene2286	1.26e-11	66.2	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RQTW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_634851_1	342610.Patl_1856	2.23e-05	50.1	COG0834@1|root,COG0834@2|Bacteria,1RIGN@1224|Proteobacteria,1RR7F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain	pedG	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
k59_1158299_1	1255043.TVNIR_2414	5.98e-144	429.0	COG0709@1|root,COG1252@1|root,COG0709@2|Bacteria,COG1252@2|Bacteria,1MWFG@1224|Proteobacteria,1RQ5Q@1236|Gammaproteobacteria,1X13W@135613|Chromatiales	135613|Chromatiales	CE	AIR synthase related protein, N-terminal domain	-	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C,Pyr_redox_2
k59_166963_1	96561.Dole_0013	1.38e-76	245.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria,2MIIZ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_516638_1	1049564.TevJSym_ba00030	2.54e-153	467.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1J4NP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA polymerase III, alpha subunit	dnaE	GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_871416_1	1303518.CCALI_01338	8.55e-26	111.0	COG0457@1|root,COG3629@1|root,COG3903@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3903@2|Bacteria	2|Bacteria	K	ADP binding	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_22,BTAD,Guanylate_cyc,NB-ARC,TPR_10,TPR_12,TPR_8,Trans_reg_C
k59_225072_1	314254.OA2633_08499	3.96e-47	162.0	COG3509@1|root,COG3509@2|Bacteria,1QYYG@1224|Proteobacteria,2U47F@28211|Alphaproteobacteria,43ZMJ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	Q	depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_516641_1	56780.SYN_01746	1.1e-35	134.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,42ME1@68525|delta/epsilon subdivisions,2WJNY@28221|Deltaproteobacteria,2MRJF@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_871425_1	1123279.ATUS01000001_gene1998	1.78e-91	285.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,1RMGS@1236|Gammaproteobacteria,1J5JZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	alkK	-	6.2.1.44	ko:K20034	ko00920,map00920	-	R10820	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_634871_1	1122604.JONR01000018_gene1081	1.43e-05	46.6	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1X36A@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_166987_1	1496688.ER33_14330	2.08e-57	186.0	COG2085@1|root,COG2085@2|Bacteria,1G18H@1117|Cyanobacteria	1117|Cyanobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
k59_1750611_1	1122236.KB905146_gene1902	5.31e-49	172.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2VJ75@28216|Betaproteobacteria,2KNIV@206350|Nitrosomonadales	206350|Nitrosomonadales	P	NnrS protein	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
k59_1633097_1	765910.MARPU_12695	3.77e-98	311.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1WWSC@135613|Chromatiales	135613|Chromatiales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_694593_1	1035308.AQYY01000002_gene43	1.04e-84	265.0	COG0498@1|root,COG0498@2|Bacteria,1TPR0@1239|Firmicutes,248YY@186801|Clostridia,25ZZJ@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS16355	PALP,Thr_synth_N
k59_1526300_1	351348.Maqu_1436	1.99e-56	197.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,464XN@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_1693849_2	305900.GV64_05105	6.58e-10	57.0	2C0ET@1|root,33A9M@2|Bacteria,1NGE5@1224|Proteobacteria,1SGID@1236|Gammaproteobacteria,1XMR9@135619|Oceanospirillales	135619|Oceanospirillales	S	TIGRFAM TIGR02449 family protein	-	-	-	ko:K09892	-	-	-	-	ko00000,ko03036	-	-	-	-
k59_1526304_1	1226994.AMZB01000122_gene2690	3.98e-72	246.0	COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1YEZ2@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Signal transducing histidine kinase, homodimeric domain	chpA	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_1526304_2	1144325.PMI22_02634	5.17e-12	65.9	COG0835@1|root,COG0835@2|Bacteria,1NA8G@1224|Proteobacteria,1SCB2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NT	chemotaxis signal transduction protein	chpC	-	-	ko:K06598	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
k59_802915_1	522306.CAP2UW1_1517	1.12e-85	279.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2VI9F@28216|Betaproteobacteria,1KPWD@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_167016_1	1047013.AQSP01000115_gene356	3.94e-77	253.0	COG0436@1|root,COG0436@2|Bacteria,2NP1C@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase	aspB	GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297	2.6.1.1,2.6.1.14	ko:K00812,ko:K22457	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R01346,R02433,R02619,R05052	RC00006,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	iHN637.CLJU_RS06550	Aminotran_1_2
k59_1633109_1	1267005.KB911258_gene233	2.89e-93	283.0	COG0683@1|root,COG0683@2|Bacteria,1MWGW@1224|Proteobacteria,2TRSD@28211|Alphaproteobacteria,3N8CB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Periplasmic binding protein	MA20_34515	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_871478_1	240016.ABIZ01000001_gene5612	2.17e-77	241.0	COG0136@1|root,COG0136@2|Bacteria,46S74@74201|Verrucomicrobia,2ITM6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_754010_1	1094715.CM001373_gene825	3.68e-73	230.0	COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,1RZQU@1236|Gammaproteobacteria,1JDG6@118969|Legionellales	118969|Legionellales	S	Glucose-regulated metallo-peptidase M90	mtfA	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90
k59_1750620_1	522306.CAP2UW1_2831	2.69e-116	344.0	COG4886@1|root,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	-	-	3.1.1.53,3.2.1.4	ko:K01179,ko:K05970	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CAP,CBM_4_9,CelD_N,Flg_new,Glyco_hydro_9,LRR_5,fn3
k59_1574929_1	983545.Glaag_4490	8.58e-90	288.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,4656T@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG2217 Cation transport ATPase	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_225132_1	743718.Isova_3015	1.15e-56	189.0	COG1192@1|root,COG1192@2|Bacteria,2GMU7@201174|Actinobacteria,4F3TJ@85017|Promicromonosporaceae	201174|Actinobacteria	D	AAA domain	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_575838_1	1298593.TOL_0445	3.17e-21	85.1	COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,1SCRA@1236|Gammaproteobacteria,1XMVY@135619|Oceanospirillales	135619|Oceanospirillales	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
k59_1750625_1	472759.Nhal_2858	1.39e-72	229.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,1WXR0@135613|Chromatiales	135613|Chromatiales	G	Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides	nagZ	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
k59_694616_1	953739.SVEN_6960	9.66e-32	124.0	COG0789@1|root,COG0789@2|Bacteria,2I8T8@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	litR	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
k59_1458907_1	404589.Anae109_0218	1.36e-59	202.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,42NA6@68525|delta/epsilon subdivisions,2WIMU@28221|Deltaproteobacteria,2YU9T@29|Myxococcales	28221|Deltaproteobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_1805218_2	1265503.KB905163_gene2065	2.08e-29	107.0	COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,1S8QZ@1236|Gammaproteobacteria,2Q74Q@267889|Colwelliaceae	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
k59_1805218_3	1111732.AZOD01000026_gene662	2.7e-23	96.3	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,1X4QH@135614|Xanthomonadales	135614|Xanthomonadales	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_1633134_1	351348.Maqu_1032	1.84e-55	185.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,467I6@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	COG0436 Aspartate tyrosine aromatic aminotransferase	aspC	-	2.6.1.1,2.6.1.84	ko:K00812,ko:K12252	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052,R08197	RC00006,RC00008	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1044099_1	644282.Deba_0084	1.1e-75	245.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1R561@1224|Proteobacteria,42NEB@68525|delta/epsilon subdivisions,2WM1V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CJ	Acetyl-CoA hydrolase transferase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1,Acetyltransf_3
k59_1633137_1	765912.Thimo_2741	1.08e-38	131.0	2EH48@1|root,33AW7@2|Bacteria,1NIYU@1224|Proteobacteria,1SEZV@1236|Gammaproteobacteria,1WZ9F@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_225146_1	1004785.AMBLS11_02665	2.61e-45	156.0	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria,466GI@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050518,GO:0070567,GO:0071704,GO:1901576	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2747,iBWG_1329.BWG_2483,iEC55989_1330.EC55989_3019,iECDH10B_1368.ECDH10B_2915,iECDH1ME8569_1439.ECDH1ME8569_2657,iECIAI1_1343.ECIAI1_2848,iECO103_1326.ECO103_3289,iECO111_1330.ECO111_3471,iECO26_1355.ECO26_3816,iECSE_1348.ECSE_2999,iECW_1372.ECW_m2953,iEKO11_1354.EKO11_1022,iEcDH1_1363.EcDH1_0941,iEcE24377_1341.EcE24377A_3048,iEcHS_1320.EcHS_A2885,iEcolC_1368.EcolC_0965,iJO1366.b2747,iJR904.b2747,iPC815.YPO3361,iSBO_1134.SBO_2773,iSDY_1059.SDY_2946,iSSON_1240.SSON_2895,iSbBS512_1146.SbBS512_E3127,iUMNK88_1353.UMNK88_3422,iWFL_1372.ECW_m2953,iY75_1357.Y75_RS14300	IspD
k59_342758_1	1439940.BAY1663_03082	1.29e-91	282.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,1RQVT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1458927_2	454957.IA64_01405	1.03e-90	295.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,1RN48@1236|Gammaproteobacteria,1X36U@135614|Xanthomonadales	135614|Xanthomonadales	CE	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
k59_1574956_1	590998.Celf_0156	1.75e-87	276.0	2BZJQ@1|root,334P7@2|Bacteria,2I8YZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
k59_1574956_2	1033736.CAHK01000032_gene1493	0.000963	41.2	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria,4F9HS@85019|Brevibacteriaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	mtrA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016310,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K07670	ko02020,map02020	M00461	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1398550_1	367299.JOEE01000004_gene1045	5.32e-40	144.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,4FFWW@85021|Intrasporangiaceae	201174|Actinobacteria	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1398550_2	1151119.KB895491_gene1851	1.5e-39	149.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,1W8BP@1268|Micrococcaceae	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537,ko:K12953	-	-	-	-	ko00000,ko01000	3.A.3,3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_575869_1	272134.KB731324_gene1285	6.64e-15	73.6	COG2890@1|root,COG2890@2|Bacteria,1G51W@1117|Cyanobacteria,1HBZ4@1150|Oscillatoriales	1117|Cyanobacteria	J	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_575869_2	225937.HP15_2144	6.9e-10	60.5	COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,1S8UU@1236|Gammaproteobacteria,4677J@72275|Alteromonadaceae	1236|Gammaproteobacteria	CO	Thioredoxin-like	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
k59_871537_1	404589.Anae109_1612	9.35e-109	319.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2WJ1I@28221|Deltaproteobacteria,2YW96@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
k59_225171_1	909943.HIMB100_00004300	2.06e-94	290.0	COG2223@1|root,COG2223@2|Bacteria,1MW71@1224|Proteobacteria,2TWVJ@28211|Alphaproteobacteria,4BP5M@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1158400_1	292415.Tbd_2647	9.2e-34	118.0	COG4576@1|root,COG4576@2|Bacteria,1N7B1@1224|Proteobacteria,2VX39@28216|Betaproteobacteria,1KTBA@119069|Hydrogenophilales	119069|Hydrogenophilales	CQ	Ethanolamine utilisation protein EutN/carboxysome	-	-	-	-	-	-	-	-	-	-	-	-	EutN_CcmL
k59_1158400_2	1458427.BAWN01000011_gene680	1.16e-49	158.0	COG4576@1|root,COG4576@2|Bacteria,1MZNS@1224|Proteobacteria,2VUR7@28216|Betaproteobacteria	28216|Betaproteobacteria	CQ	Ethanolamine utilisation protein EutN/carboxysome	-	-	-	-	-	-	-	-	-	-	-	-	EutN_CcmL
k59_1044159_1	882.DVU_0258	9.85e-47	168.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1QZPK@1224|Proteobacteria,42NQE@68525|delta/epsilon subdivisions,2WJPH@28221|Deltaproteobacteria,2M8MZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_4,PAS_9,Response_reg
k59_1633189_1	75379.Tint_0726	9.97e-24	97.8	COG0664@1|root,COG0664@2|Bacteria,1NI7I@1224|Proteobacteria	1224|Proteobacteria	T	PFAM Cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_1805260_1	247156.NFA_32370	8.42e-51	166.0	COG5646@1|root,COG5646@2|Bacteria,2IINN@201174|Actinobacteria,4G0JA@85025|Nocardiaceae	201174|Actinobacteria	S	InterPro IPR014922	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
k59_634967_1	754477.Q7C_2281	1.78e-56	191.0	COG1295@1|root,COG1959@1|root,COG1295@2|Bacteria,COG1959@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,45ZQW@72273|Thiotrichales	72273|Thiotrichales	K	TIGRFAM YihY family protein (not ribonuclease BN)	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
k59_1458959_1	365528.KB891192_gene3604	1.59e-70	220.0	COG1028@1|root,COG1028@2|Bacteria,2GMG3@201174|Actinobacteria,4ERGA@85013|Frankiales	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1458959_2	196162.Noca_1828	3.45e-11	62.4	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4DPEV@85009|Propionibacteriales	201174|Actinobacteria	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_634973_1	1249627.D779_0480	3.67e-60	192.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,1WX9J@135613|Chromatiales	135613|Chromatiales	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_634973_2	631362.Thi970DRAFT_05000	3.16e-22	96.3	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RY8P@1236|Gammaproteobacteria,1WWGX@135613|Chromatiales	135613|Chromatiales	E	PFAM amino acid permease-associated region	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_1633210_2	742767.HMPREF9456_01259	5.18e-14	70.9	COG2220@1|root,COG2220@2|Bacteria,4NFJ4@976|Bacteroidetes,2FNMD@200643|Bacteroidia,22YAB@171551|Porphyromonadaceae	976|Bacteroidetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
k59_225205_1	1121405.dsmv_0687	1.09e-38	144.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria,2MJ1V@213118|Desulfobacterales	28221|Deltaproteobacteria	S	TIGRFAM TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_225205_2	933262.AXAM01000016_gene149	6.49e-50	176.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM penicillin-binding protein, 1A family	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
k59_634980_1	1280950.HJO_04705	1.14e-19	87.4	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,2TRC9@28211|Alphaproteobacteria,43W7G@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	MazG family	mazG	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
k59_575920_1	1068980.ARVW01000001_gene1768	8.81e-13	72.8	COG1595@1|root,COG1595@2|Bacteria,2HGII@201174|Actinobacteria,4E5WC@85010|Pseudonocardiales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_871604_1	425104.Ssed_0613	1.93e-95	301.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,2QA7M@267890|Shewanellaceae	1236|Gammaproteobacteria	M	PFAM MscS Mechanosensitive ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel
k59_1633245_1	257310.BB3815	2.1e-57	193.0	COG0477@1|root,COG2814@2|Bacteria,1QW9T@1224|Proteobacteria,2W1Q9@28216|Betaproteobacteria,3T5SY@506|Alcaligenaceae	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1750727_1	1384056.N787_11595	1.1e-63	211.0	COG1757@1|root,COG1757@2|Bacteria,1MVDF@1224|Proteobacteria,1RS40@1236|Gammaproteobacteria,1X56I@135614|Xanthomonadales	135614|Xanthomonadales	C	Na+/H+ antiporter family	-	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
k59_696251_1	107636.JQNK01000009_gene1461	4.23e-75	230.0	COG1670@1|root,COG1670@2|Bacteria,1RB1I@1224|Proteobacteria,2U5AF@28211|Alphaproteobacteria,36ZI0@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Domain of unknown function (DUF4202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4202
k59_1460562_1	68570.DC74_4741	1.07e-05	45.8	COG0245@1|root,COG0245@2|Bacteria,2II8H@201174|Actinobacteria	201174|Actinobacteria	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008685,GO:0009058,GO:0009987,GO:0016114,GO:0016829,GO:0016849,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0051483,GO:0071704,GO:1901576	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3581c	YgbB
k59_1460562_2	1906.SFRA_08805	1.38e-53	179.0	COG1211@1|root,COG1211@2|Bacteria,2GNHP@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
k59_1460562_3	58123.JOFJ01000020_gene3738	8.41e-16	72.0	COG1329@1|root,COG1329@2|Bacteria,2GKSU@201174|Actinobacteria,4EFNK@85012|Streptosporangiales	201174|Actinobacteria	K	transcriptional regulator	carD	GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0040007,GO:0042594,GO:0044419,GO:0050896,GO:0051704,GO:0051716,GO:0071496	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
k59_344370_1	1121445.ATUZ01000013_gene1153	9.5e-62	199.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NTG@68525|delta/epsilon subdivisions,2WKHW@28221|Deltaproteobacteria,2M8FK@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	PFAM ABC transporter related	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
k59_1577040_2	991905.SL003B_1916	4.41e-22	95.1	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2TQKT@28211|Alphaproteobacteria,4BPBW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_1752111_1	384765.SIAM614_16427	3.33e-48	167.0	COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2TS0X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	nasF	-	-	ko:K15576	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	NMT1_2
k59_1408915_2	472175.EL18_01626	2.6e-46	158.0	COG3216@1|root,COG3216@2|Bacteria,1QA1I@1224|Proteobacteria,2TS9W@28211|Alphaproteobacteria,43K7Z@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
k59_812026_1	1049564.TevJSym_ab00630	1.4e-14	73.2	COG0577@1|root,COG0577@2|Bacteria,1QRYR@1224|Proteobacteria,1S0ZU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	tagS	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_812026_2	1049564.TevJSym_ab00640	1.1e-109	323.0	COG1136@1|root,COG1136@2|Bacteria,1RCXK@1224|Proteobacteria,1S7TZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	abc transporter atp-binding protein	attE	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1642913_1	717773.Thicy_0346	7.95e-11	68.6	COG2911@1|root,COG3210@1|root,COG3595@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG3595@2|Bacteria,1P8N9@1224|Proteobacteria,1RYB2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1760541_1	1268237.G114_18506	6.64e-41	155.0	COG0260@1|root,COG0260@2|Bacteria,1MXP6@1224|Proteobacteria,1RYKJ@1236|Gammaproteobacteria,1Y6IF@135624|Aeromonadales	135624|Aeromonadales	E	Belongs to the peptidase M17 family	-	-	3.4.11.1,3.4.11.5	ko:K01255,ko:K01259	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00135,R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17
k59_1760554_1	335543.Sfum_3600	1.05e-78	238.0	COG4871@1|root,COG4871@2|Bacteria,1RF0E@1224|Proteobacteria,42RKU@68525|delta/epsilon subdivisions,2WNHT@28221|Deltaproteobacteria,2MRPZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Putative Fe-S cluster	-	-	-	-	-	-	-	-	-	-	-	-	FeS
k59_645085_1	454957.IA64_19085	1.59e-87	272.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1X55Q@135614|Xanthomonadales	135614|Xanthomonadales	EH	component I	pabB	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_1642930_1	439235.Dalk_4847	9.37e-59	194.0	COG3385@1|root,COG3385@2|Bacteria,1RCTP@1224|Proteobacteria,431NI@68525|delta/epsilon subdivisions,2WWWQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1171106_1	713586.KB900536_gene2552	3.17e-64	202.0	COG2143@1|root,COG2143@2|Bacteria,1RB3S@1224|Proteobacteria,1S2A7@1236|Gammaproteobacteria,1WXYQ@135613|Chromatiales	135613|Chromatiales	O	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
k59_1760603_1	401526.TcarDRAFT_2056	1.35e-36	140.0	COG0621@1|root,COG0621@2|Bacteria,1TNYN@1239|Firmicutes,4H1VJ@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_1760603_2	335543.Sfum_0418	6.28e-54	173.0	COG1259@1|root,COG1259@2|Bacteria,1RFFV@1224|Proteobacteria,42SCI@68525|delta/epsilon subdivisions,2WPWT@28221|Deltaproteobacteria,2MQHM@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
k59_645148_1	290398.Csal_1552	5.52e-86	264.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1XHPM@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_1171142_1	765910.MARPU_00500	1.59e-193	548.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1WXUS@135613|Chromatiales	135613|Chromatiales	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_812108_1	582899.Hden_2871	1.02e-136	402.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,3N6AK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	etf	GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070013,GO:0098573,GO:0098798,GO:1902494,GO:1990204	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8,Thi4
k59_526045_1	566461.SSFG_00378	6.81e-31	124.0	COG3591@1|root,COG3591@2|Bacteria,2GJVS@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the glycosyl hydrolase 3 family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_645219_2	1461693.ATO10_13579	5.03e-26	103.0	COG5530@1|root,COG5530@2|Bacteria,1R6P3@1224|Proteobacteria,2TUPW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2270
k59_585504_1	270374.MELB17_19981	4.77e-52	186.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,464DC@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_1760695_1	697282.Mettu_1699	2.27e-46	171.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XFYJ@135618|Methylococcales	135618|Methylococcales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF,PAS_4,PAS_9
k59_1171217_1	335543.Sfum_3683	7.42e-48	163.0	2C0QF@1|root,32R7C@2|Bacteria,1MYZK@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_526127_1	1278073.MYSTI_03336	8.72e-77	251.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,43BBS@68525|delta/epsilon subdivisions,2X6QY@28221|Deltaproteobacteria,2YU79@29|Myxococcales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_526132_1	1279017.AQYJ01000022_gene2737	1.32e-61	215.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,464K7@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG1643 HrpA-like helicases	hrpA	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_526150_1	157783.LK03_12445	1.15e-33	128.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,1RMFK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NT	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	cheR	GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0050896	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
k59_526150_2	1123228.AUIH01000041_gene2965	3.75e-08	54.3	COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1N81M@1224|Proteobacteria,1RPS1@1236|Gammaproteobacteria,1XHJD@135619|Oceanospirillales	135619|Oceanospirillales	T	Two component signalling adaptor domain	-	-	-	ko:K03415	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	CheW,Response_reg
k59_1643116_1	56780.SYN_00025	2.26e-44	158.0	COG0845@1|root,COG0845@2|Bacteria,1MUMV@1224|Proteobacteria,42PK1@68525|delta/epsilon subdivisions,2WJ65@28221|Deltaproteobacteria,2MQ6M@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_1816911_1	765914.ThisiDRAFT_1140	1.34e-08	55.5	COG5341@1|root,COG5341@2|Bacteria	2|Bacteria	S	NusG domain II	-	-	-	-	-	-	-	-	-	-	-	-	NusG_II
k59_1816911_2	1415780.JPOG01000001_gene143	5.59e-26	101.0	COG4769@1|root,COG4769@2|Bacteria,1RJIB@1224|Proteobacteria,1SBYC@1236|Gammaproteobacteria,1XANM@135614|Xanthomonadales	135614|Xanthomonadales	S	Heptaprenyl diphosphate synthase component I	-	-	-	-	-	-	-	-	-	-	-	-	Hpre_diP_synt_I
k59_1816915_1	1267005.KB911259_gene3689	3.42e-29	119.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,3N63V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	ko:K21470,ko:K21572	-	-	-	-	ko00000,ko01002,ko01011,ko02000	8.A.46.1,8.A.46.3	-	-	PG_binding_1,YkuD
k59_585590_2	1454004.AW11_03549	1.15e-47	168.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,2VMUK@28216|Betaproteobacteria	28216|Betaproteobacteria	O	serine protease	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
k59_1816930_1	1123401.JHYQ01000011_gene1437	3.09e-96	302.0	COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,1RN9V@1236|Gammaproteobacteria,460AS@72273|Thiotrichales	72273|Thiotrichales	C	radical SAM protein YgiQ	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
k59_1171288_1	1049564.TevJSym_aq00490	2.23e-82	258.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1J4PN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009226,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0018130,GO:0019134,GO:0019438,GO:0030203,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0042546,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046872,GO:0055086,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903509	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iECED1_1282.ECED1_4420,iYL1228.KPN_04135	Hexapep,Hexapep_2,NTP_transf_3
k59_812230_1	1265313.HRUBRA_01473	1.4e-68	225.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria,1J8WI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	AMP-binding enzyme	JD73_00810	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C_2,PP-binding
k59_526196_1	326297.Sama_1463	2.4e-134	396.0	COG3203@1|root,COG3203@2|Bacteria,1QYZC@1224|Proteobacteria,1T3Y7@1236|Gammaproteobacteria,2Q951@267890|Shewanellaceae	1236|Gammaproteobacteria	M	outer membrane porin, OprD family	-	-	-	-	-	-	-	-	-	-	-	-	OprD
k59_526196_2	326297.Sama_1464	3.03e-09	57.0	COG2159@1|root,COG2159@2|Bacteria,1R8EW@1224|Proteobacteria,1RYM3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_526207_3	1123399.AQVE01000002_gene2290	2.87e-06	48.9	COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,460CK@72273|Thiotrichales	72273|Thiotrichales	K	acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10,DUF3335
k59_645354_1	1278073.MYSTI_07208	3.69e-32	123.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2WQ59@28221|Deltaproteobacteria,2YV5F@29|Myxococcales	28221|Deltaproteobacteria	O	Redoxin	prx-4	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_526228_1	439235.Dalk_4000	2.02e-70	215.0	COG0537@1|root,COG0537@2|Bacteria,1RHYQ@1224|Proteobacteria,42SEG@68525|delta/epsilon subdivisions,2WPFW@28221|Deltaproteobacteria,2MNPP@213118|Desulfobacterales	28221|Deltaproteobacteria	FG	HIT domain	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	CwfJ_C_1,HIT
k59_1171343_1	1123261.AXDW01000014_gene3280	1.32e-61	197.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1X3PE@135614|Xanthomonadales	135614|Xanthomonadales	F	Belongs to the SAICAR synthetase family	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
k59_812278_1	1121405.dsmv_2304	3.24e-68	211.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria	1224|Proteobacteria	I	phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	clsB	-	-	ko:K06131,ko:K06132	ko00564,ko01100,map00564,map01100	-	R07390,R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_645413_1	1211815.CBYP010000073_gene3618	6.87e-15	72.0	COG0262@1|root,COG0262@2|Bacteria,2IN33@201174|Actinobacteria	201174|Actinobacteria	H	PFAM bifunctional deaminase-reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_1816987_1	330214.NIDE0816	1.75e-29	124.0	COG0745@1|root,COG0784@1|root,COG2198@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG5002@2|Bacteria,3J0ZF@40117|Nitrospirae	2|Bacteria	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,CHASE8,GAF,GAF_3,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_1171372_1	177437.HRM2_11810	8.77e-29	117.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P5K@68525|delta/epsilon subdivisions,2WMEF@28221|Deltaproteobacteria,2MJFC@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1643865_2	1045009.AFXQ01000011_gene484	2.62e-42	146.0	COG1101@1|root,COG1101@2|Bacteria,2GNP6@201174|Actinobacteria,1W7P6@1268|Micrococcaceae	201174|Actinobacteria	S	ABC transporter	-	-	-	ko:K05833	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
k59_1232932_1	1043493.BBLU01000004_gene2725	1.63e-224	644.0	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria	201174|Actinobacteria	G	hydrolase, family 65, central catalytic	-	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
k59_352404_1	998674.ATTE01000001_gene2612	6.88e-41	147.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,4620M@72273|Thiotrichales	72273|Thiotrichales	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
k59_822001_1	398767.Glov_1358	7.2e-83	248.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,42QS6@68525|delta/epsilon subdivisions,2WMPD@28221|Deltaproteobacteria,43TH5@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_1702560_1	1121447.JONL01000002_gene1996	5.92e-75	240.0	COG4782@1|root,COG4782@2|Bacteria,1PSSD@1224|Proteobacteria,430S8@68525|delta/epsilon subdivisions,2WW3H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Alpha/beta hydrolase of unknown function (DUF900)	-	-	-	-	-	-	-	-	-	-	-	-	DUF900
k59_1467758_1	2340.JV46_25530	3.1e-28	114.0	COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,1RMJ1@1236|Gammaproteobacteria,1J5R3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_integrase
k59_939469_1	1123065.ATWL01000009_gene999	2.24e-159	475.0	COG1205@1|root,COG1205@2|Bacteria,2GJJ6@201174|Actinobacteria	201174|Actinobacteria	L	dead DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
k59_645892_1	1035308.AQYY01000002_gene327	2.5e-92	293.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia,2601Z@186807|Peptococcaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_939478_1	429009.Adeg_0886	3.02e-30	114.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,42G9G@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_822014_1	1123073.KB899242_gene1182	7.62e-30	122.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1X3DY@135614|Xanthomonadales	135614|Xanthomonadales	C	NADH-quinone oxidoreductase	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_352429_1	1095767.CAHD01000046_gene1417	1.24e-37	134.0	COG3981@1|root,COG3981@2|Bacteria,2IGK9@201174|Actinobacteria	201174|Actinobacteria	L	Gcn5-related n-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3
k59_1643890_1	929556.Solca_0287	1.65e-84	258.0	COG0074@1|root,COG0074@2|Bacteria,4NE6B@976|Bacteroidetes,1INZ1@117747|Sphingobacteriia	976|Bacteroidetes	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA,Succ_CoA_lig
k59_1350353_2	96561.Dole_2255	3.61e-19	87.0	COG0247@1|root,COG0247@2|Bacteria,1R467@1224|Proteobacteria,42NIQ@68525|delta/epsilon subdivisions,2WIUU@28221|Deltaproteobacteria,2MQ10@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	hmcF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17
k59_1585153_1	395493.BegalDRAFT_3522	1.1e-64	214.0	COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,1RNXP@1236|Gammaproteobacteria,45ZTY@72273|Thiotrichales	72273|Thiotrichales	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme	-	-	-	-	-	-	-	-	-	-	-	-	RLAN,RimK
k59_1585153_2	395493.BegalDRAFT_3521	2.5e-39	141.0	COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,460CK@72273|Thiotrichales	72273|Thiotrichales	K	acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10,DUF3335
k59_939506_1	1049564.TevJSym_bo00190	5.95e-96	307.0	COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,1RQ9A@1236|Gammaproteobacteria,1J616@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	ko:K02569	-	-	-	-	ko00000	-	-	-	Cytochrom_NNT,EB_dh
k59_117561_1	313612.L8106_11342	1.68e-05	53.1	COG1357@1|root,COG1357@2|Bacteria,1G37B@1117|Cyanobacteria,1HAA6@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Pentapeptide repeats (8 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
k59_293665_2	998088.B565_3183	1.02e-54	183.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,1RN67@1236|Gammaproteobacteria,1Y52B@135624|Aeromonadales	135624|Aeromonadales	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
k59_1115541_1	765911.Thivi_4560	6.57e-67	218.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1WX1C@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_1702589_1	391615.ABSJ01000050_gene1170	9.85e-11	66.2	COG3156@1|root,COG3156@2|Bacteria,1RBNV@1224|Proteobacteria,1SASH@1236|Gammaproteobacteria,1JAPT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Type II secretion system (T2SS), protein K	gspK	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
k59_117565_1	1244869.H261_19024	4.16e-42	147.0	COG3677@1|root,COG3677@2|Bacteria,1REPF@1224|Proteobacteria,2U8CB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_293670_1	323261.Noc_0352	9.04e-59	196.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WXBN@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD linked oxidase domain protein	-	-	1.1.5.12	ko:K03777	ko00620,ko01120,map00620,map01120	-	R00704,R11591	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_293670_2	247634.GPB2148_2962	2.23e-10	58.5	COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,1S8WT@1236|Gammaproteobacteria,1J6MW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Stringent starvation protein B	sspB	GO:0000502,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0009376,GO:0009893,GO:0009894,GO:0009896,GO:0010604,GO:0019222,GO:0019899,GO:0031597,GO:0032781,GO:0032991,GO:0042176,GO:0042802,GO:0042803,GO:0043085,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043462,GO:0044093,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045732,GO:0046983,GO:0048518,GO:0050789,GO:0050790,GO:0051117,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051336,GO:0051345,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:1901363,GO:1902494,GO:1904949,GO:1905368,GO:1905369,GO:1990904	-	ko:K03600	-	-	-	-	ko00000,ko03021	-	-	-	SspB
k59_998166_1	1397528.Q671_15965	1.7e-90	276.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1XI3Q@135619|Oceanospirillales	135619|Oceanospirillales	M	Catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_1820113_1	504472.Slin_0576	1.4e-30	124.0	COG0308@1|root,COG0308@2|Bacteria,4NGTZ@976|Bacteroidetes,47MWS@768503|Cytophagia	976|Bacteroidetes	E	Peptidase family M1 domain	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
k59_528493_1	1201290.M902_0851	7.23e-05	45.8	COG5184@1|root,COG5184@2|Bacteria,1QX3H@1224|Proteobacteria,42QVK@68525|delta/epsilon subdivisions,2MTTS@213481|Bdellovibrionales,2WN77@28221|Deltaproteobacteria	213481|Bdellovibrionales	DZ	cell wall surface anchor family protein	-	-	-	-	-	-	-	-	-	-	-	-	RCC1,RCC1_2
k59_763329_1	367299.JOEE01000004_gene1212	1.32e-152	438.0	COG1748@1|root,COG1748@2|Bacteria,2GMQ1@201174|Actinobacteria,4FFH8@85021|Intrasporangiaceae	201174|Actinobacteria	E	COG1748 Saccharopine dehydrogenase and related	lys1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_704630_1	2340.JV46_21580	2.01e-88	267.0	COG0457@1|root,COG0457@2|Bacteria,1R85G@1224|Proteobacteria,1S0MD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_704630_2	1249627.D779_2141	3.14e-24	92.4	2E3CD@1|root,32YBP@2|Bacteria,1N8PD@1224|Proteobacteria,1SCSK@1236|Gammaproteobacteria,1WZ7C@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_704630_3	1430440.MGMSRv2_3913	9.3e-09	56.2	COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,2U84I@28211|Alphaproteobacteria,2JVNW@204441|Rhodospirillales	204441|Rhodospirillales	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_1585182_1	1323663.AROI01000009_gene3479	2.62e-61	213.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RYP9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
k59_117588_1	768671.ThimaDRAFT_3029	1.53e-94	297.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,1X2UG@135613|Chromatiales	135613|Chromatiales	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_411086_2	35754.JNYJ01000071_gene4228	2.97e-32	115.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	lsrG	-	5.3.1.32	ko:K11530	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	ABM
k59_704636_1	575540.Isop_0635	2.98e-40	150.0	COG0348@1|root,COG1143@1|root,COG0348@2|Bacteria,COG1143@2|Bacteria,2IZ24@203682|Planctomycetes	203682|Planctomycetes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_7
k59_587226_1	1267534.KB906754_gene3219	6.68e-15	80.5	COG0421@1|root,COG0421@2|Bacteria,3Y6UP@57723|Acidobacteria	57723|Acidobacteria	E	Spermine/spermidine synthase domain	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
k59_293692_1	290512.Paes_0646	6.66e-09	57.8	COG2963@1|root,COG2963@2|Bacteria,1FES5@1090|Chlorobi	2|Bacteria	L	PFAM transposase IS3 IS911 family protein	-	-	-	ko:K07483,ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1,TniQ,TnsD
k59_176299_1	472759.Nhal_2872	1.62e-96	316.0	COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1SYTD@1236|Gammaproteobacteria,1X2IM@135613|Chromatiales	135613|Chromatiales	EO	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M1,Peptidase_M28
k59_1409092_1	1440774.Y900_027885	7.16e-95	288.0	COG0674@1|root,COG0674@2|Bacteria,2I995@201174|Actinobacteria,237Z9@1762|Mycobacteriaceae	201174|Actinobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	porA	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1409092_2	1454004.AW11_01660	3.32e-79	241.0	COG1014@1|root,COG1014@2|Bacteria,1N12F@1224|Proteobacteria,2VQ8C@28216|Betaproteobacteria	28216|Betaproteobacteria	C	TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit	porC	-	1.2.1.58,1.2.7.1	ko:K00172,ko:K18357	ko00010,ko00020,ko00360,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00360,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R02450,R08034	RC00004,RC00250,RC02742,RC02833,RC02860	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
k59_352522_1	1304865.JAGF01000001_gene2834	2.52e-144	427.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2I312@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HATPase_c_2,HisKA_3
k59_352522_2	562973.HMPREF0059_02038	3.09e-35	125.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,4D39I@85005|Actinomycetales	201174|Actinobacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1643947_1	1163617.SCD_n00416	2.04e-85	273.0	COG2831@1|root,COG2831@2|Bacteria,1MWEC@1224|Proteobacteria,2VJXF@28216|Betaproteobacteria	28216|Betaproteobacteria	U	hemolysin activation secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	POTRA_2,ShlB
k59_536462_1	396588.Tgr7_0696	2.32e-07	52.8	COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1WWFZ@135613|Chromatiales	135613|Chromatiales	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase
k59_829808_1	1033736.CAHK01000007_gene2310	2.53e-43	159.0	COG0739@1|root,COG0739@2|Bacteria,2GKXN@201174|Actinobacteria,4F9K5@85019|Brevibacteriaceae	201174|Actinobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_1534062_1	953739.SVEN_0306	8.61e-06	52.4	COG1680@1|root,COG1680@2|Bacteria,2GJQG@201174|Actinobacteria	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,Peptidase_M6
k59_1182338_1	1027273.GZ77_13125	2.07e-33	124.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1XJ61@135619|Oceanospirillales	135619|Oceanospirillales	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
k59_1182338_2	1129374.AJE_13699	2.72e-71	225.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,464HV@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_1066836_1	1304865.JAGF01000001_gene2260	5.47e-87	275.0	COG1263@1|root,COG1264@1|root,COG2190@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,COG2190@2|Bacteria,2GK6B@201174|Actinobacteria	201174|Actinobacteria	G	Pts system	bglF	-	-	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	M00271	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6	-	-	PTS_EIIA_1,PTS_EIIB,PTS_EIIC
k59_892241_1	1463921.JODF01000077_gene192	1.26e-69	226.0	COG0624@1|root,COG0624@2|Bacteria,2GM84@201174|Actinobacteria	201174|Actinobacteria	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_892241_2	1386089.N865_04890	1.23e-25	104.0	COG3965@1|root,COG3965@2|Bacteria,2HXXU@201174|Actinobacteria,4FIDE@85021|Intrasporangiaceae	201174|Actinobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
k59_125594_1	717606.PaecuDRAFT_0475	2.42e-35	132.0	COG1307@1|root,COG1307@2|Bacteria,1TRM7@1239|Firmicutes,4HBIR@91061|Bacilli,26S8K@186822|Paenibacillaceae	91061|Bacilli	S	DegV family	degV3	-	-	-	-	-	-	-	-	-	-	-	DegV
k59_246693_1	1049564.TevJSym_bw00080	7.85e-122	362.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1J5FV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_1242313_1	1121033.AUCF01000029_gene293	1.41e-23	99.4	2C7F6@1|root,2Z8AK@2|Bacteria,1PEE5@1224|Proteobacteria,2TTH2@28211|Alphaproteobacteria,2JR3R@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1242313_2	426117.M446_3081	1.31e-11	65.1	28NIR@1|root,2ZBK2@2|Bacteria,1RAAF@1224|Proteobacteria,2U5XR@28211|Alphaproteobacteria,1JTAC@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_951257_1	941449.dsx2_2392	4.29e-110	346.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42N22@68525|delta/epsilon subdivisions,2WIMH@28221|Deltaproteobacteria,2M91S@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_653921_1	1123228.AUIH01000001_gene1377	1.62e-37	153.0	2C2C7@1|root,2Z85G@2|Bacteria,1PD07@1224|Proteobacteria,1RP6G@1236|Gammaproteobacteria,1XIKZ@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_477642_1	1169143.KB911040_gene2876	1.01e-88	286.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,1JZNE@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Formate dehydrogenase alpha subunit	fdsA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_418791_1	697282.Mettu_4376	1.17e-141	414.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1XDNE@135618|Methylococcales	135618|Methylococcales	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	-	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
k59_1122262_2	292415.Tbd_1582	2.06e-85	276.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2VKF8@28216|Betaproteobacteria,1KSFY@119069|Hydrogenophilales	119069|Hydrogenophilales	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_1652183_1	153948.NAL212_2720	2.45e-50	172.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2VJIC@28216|Betaproteobacteria,372NX@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_594958_1	2340.JV46_10460	1.01e-42	141.0	COG2146@1|root,COG2146@2|Bacteria,1N03R@1224|Proteobacteria,1S9CV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	nitrite reductase	nirD	-	1.7.1.15	ko:K00363	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,Rieske_2
k59_594958_2	1163617.SCD_n02266	3.81e-44	159.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1768564_1	1123073.KB899241_gene2690	2.3e-97	303.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1X5SE@135614|Xanthomonadales	135614|Xanthomonadales	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_364044_1	158189.SpiBuddy_1049	1.73e-22	103.0	COG3014@1|root,COG3014@2|Bacteria,2J7CY@203691|Spirochaetes	203691|Spirochaetes	S	protein conserved in bacteria	-	-	-	ko:K09859	-	-	-	-	ko00000	-	-	-	-
k59_364044_2	1121104.AQXH01000001_gene978	6.92e-09	56.2	COG3417@1|root,COG3417@2|Bacteria,4NFXF@976|Bacteroidetes,1IQZR@117747|Sphingobacteriia	976|Bacteroidetes	M	Peptidoglycan-synthase activator LpoB	-	-	-	ko:K07337	-	-	-	-	ko00000	-	-	-	LpoB
k59_246726_1	762963.HMPREF9056_00409	2.63e-30	124.0	COG5263@1|root,COG5479@1|root,COG5263@2|Bacteria,COG5479@2|Bacteria,2GNDB@201174|Actinobacteria,4D3RQ@85005|Actinomycetales	201174|Actinobacteria	M	N-acetylmuramoyl-L-alanine amidase	csp	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,LGFP
k59_1066867_1	765912.Thimo_0119	1.8e-138	412.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1WXQN@135613|Chromatiales	135613|Chromatiales	EQ	PFAM Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k59_418812_1	395494.Galf_2265	9.43e-96	307.0	COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,1MV6M@1224|Proteobacteria,2VIEC@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Helicase	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SWIM
k59_1477358_1	1005048.CFU_0788	5.46e-30	115.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2VHW8@28216|Betaproteobacteria,473WN@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
k59_364060_1	1049564.TevJSym_ar00510	1.24e-56	183.0	COG4106@1|root,COG4106@2|Bacteria,1QWJU@1224|Proteobacteria	1224|Proteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
k59_892285_1	517417.Cpar_0088	4.91e-114	339.0	COG0004@1|root,COG0004@2|Bacteria,1FDG1@1090|Chlorobi	1090|Chlorobi	P	PFAM Rh family protein ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_1303489_1	762963.HMPREF9056_02063	1.55e-69	219.0	COG1192@1|root,COG1192@2|Bacteria,2GJX3@201174|Actinobacteria,4D3TD@85005|Actinomycetales	201174|Actinobacteria	D	CobQ CobB MinD ParA nucleotide binding domain protein	soj	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_1303489_2	471853.Bcav_2159	6.77e-86	261.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	xerD	GO:0008150,GO:0040007	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_536477_4	1144275.COCOR_02835	3.09e-56	189.0	COG4249@1|root,COG4249@2|Bacteria,1R45G@1224|Proteobacteria,42WYW@68525|delta/epsilon subdivisions,2WTAZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
k59_70605_1	880072.Desac_1578	3.14e-88	271.0	COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,42NJB@68525|delta/epsilon subdivisions,2WM62@28221|Deltaproteobacteria,2MS28@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2333)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2333
k59_246764_1	1122933.JNIY01000009_gene1351	1.1e-139	410.0	COG0119@1|root,COG0119@2|Bacteria,2GKYT@201174|Actinobacteria,4F102@85016|Cellulomonadaceae	201174|Actinobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA2	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1768583_1	765910.MARPU_15960	1.07e-91	272.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1WVXJ@135613|Chromatiales	135613|Chromatiales	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
k59_1534106_1	1121904.ARBP01000041_gene4946	1.44e-21	99.8	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,4NDXU@976|Bacteroidetes,47JK3@768503|Cytophagia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg
k59_1592488_1	1249627.D779_1785	9.74e-109	346.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1WX8F@135613|Chromatiales	135613|Chromatiales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_1710190_1	1167006.UWK_00715	6.27e-139	413.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42NQG@68525|delta/epsilon subdivisions,2WJXC@28221|Deltaproteobacteria,2MJBJ@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM DNA topoisomerase III, bacteria and conjugative plasmid	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	DEAD,HRDC,Helicase_C,RecQ_Zn_bind,Topoisom_bac,Toprim,Toprim_Crpt,zf-C4_Topoisom
k59_1122284_1	472759.Nhal_0867	6.96e-35	127.0	COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,1S3RM@1236|Gammaproteobacteria,1WYEW@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1122284_2	472759.Nhal_1114	3.26e-25	105.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,1S059@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_1004953_1	1123024.AUII01000014_gene4289	4.55e-65	214.0	COG1690@1|root,COG1690@2|Bacteria,2GIUP@201174|Actinobacteria,4E0T7@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the RtcB family	rtcB	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_1358157_1	314345.SPV1_00345	2.27e-73	246.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria	1224|Proteobacteria	P	ATPase, P-type transporting, HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_712679_1	1095769.CAHF01000011_gene2676	2.48e-146	437.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2VKDZ@28216|Betaproteobacteria,472NE@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Aconitase C-terminal domain	acnD	-	4.2.1.117,4.2.1.3	ko:K01681,ko:K20455	ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900,R11263	RC00497,RC00498,RC00618,RC01152	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_712679_2	1415754.JQMK01000002_gene3600	1.1e-15	75.5	COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,1RNE6@1236|Gammaproteobacteria,464AI@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	prpF	-	-	ko:K09788	ko00640,map00640	-	R11264	RC03405	ko00000,ko00001,ko01000	-	-	-	PrpF
k59_301603_1	292415.Tbd_1583	2.64e-66	207.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VJ7G@28216|Betaproteobacteria,1KSMU@119069|Hydrogenophilales	119069|Hydrogenophilales	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_301603_2	1123368.AUIS01000028_gene1326	9.79e-40	150.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_184367_2	96561.Dole_2746	9.71e-25	103.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42M1W@68525|delta/epsilon subdivisions,2WK53@28221|Deltaproteobacteria,2MIJV@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_246788_1	96561.Dole_0330	9.59e-22	94.0	COG3168@1|root,COG3168@2|Bacteria,1N39F@1224|Proteobacteria,42U30@68525|delta/epsilon subdivisions,2WRT8@28221|Deltaproteobacteria,2MPRF@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Pilus assembly protein, PilP	-	-	-	ko:K02665	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilP
k59_1592495_1	335543.Sfum_3769	1.69e-63	209.0	COG1413@1|root,COG3012@1|root,COG1413@2|Bacteria,COG3012@2|Bacteria,1QZ4P@1224|Proteobacteria	1224|Proteobacteria	C	Pfam SEC-C motif	-	-	-	-	-	-	-	-	-	-	-	-	SEC-C
k59_712683_1	1144325.PMI22_00608	7.79e-87	271.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1S3FP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_1768596_1	1121405.dsmv_2999	1.16e-81	255.0	COG1013@1|root,COG1014@1|root,COG1013@2|Bacteria,COG1014@2|Bacteria,1R7US@1224|Proteobacteria,42PFT@68525|delta/epsilon subdivisions,2WMBJ@28221|Deltaproteobacteria,2MJ1Z@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,TPP_enzyme_C
k59_951319_1	314292.VAS14_21407	1.44e-30	124.0	COG0165@1|root,COG1246@1|root,COG0165@2|Bacteria,COG1246@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1XSAT@135623|Vibrionales	135623|Vibrionales	E	belongs to the lyase 1 family. Argininosuccinate lyase subfamily	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,4.3.2.1	ko:K14681	ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230	M00028,M00029,M00844	R00259,R01086	RC00004,RC00064,RC00445,RC00447	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C2,Acetyltransf_1,Lyase_1
k59_594992_1	1212548.B381_11038	3.51e-152	447.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1Z0GJ@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	L	single-stranded-DNA-specific exonuclease RecJ	recJ	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_418844_1	1449976.KALB_4145	1.21e-20	92.8	COG1155@1|root,COG1155@2|Bacteria,2HESQ@201174|Actinobacteria,4DYJN@85010|Pseudonocardiales	201174|Actinobacteria	C	ATPsynthase alpha/beta subunit N-term extension	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_1710192_2	748658.KB907313_gene2072	6.06e-49	159.0	COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,1S8XH@1236|Gammaproteobacteria,1X13D@135613|Chromatiales	135613|Chromatiales	P	Arsenate reductase and related	-	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
k59_1710192_3	765912.Thimo_1636	2.72e-100	295.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,1S23B@1236|Gammaproteobacteria,1WW1Q@135613|Chromatiales	135613|Chromatiales	S	Belongs to the WrbA family	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
k59_1710192_4	395493.BegalDRAFT_2716	4.43e-49	167.0	COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,4611E@72273|Thiotrichales	72273|Thiotrichales	L	Belongs to the DnaA family. HdA subfamily	-	-	-	ko:K10763	-	-	-	-	ko00000,ko03032	-	-	-	Bac_DnaA
k59_829877_1	187272.Mlg_2558	1.01e-134	407.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales	135613|Chromatiales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1004965_1	1168059.KB899087_gene3612	1.63e-24	107.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_892327_1	670307.HYPDE_37628	8.15e-83	264.0	COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1RGCV@1224|Proteobacteria,2US4Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_4
k59_1303533_1	1304865.JAGF01000001_gene3274	8.94e-134	399.0	COG1640@1|root,COG1640@2|Bacteria,2GM5Z@201174|Actinobacteria,4F0RR@85016|Cellulomonadaceae	201174|Actinobacteria	G	PFAM glycoside hydrolase family 77	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_595003_1	1123368.AUIS01000005_gene485	3.19e-97	298.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,2NBSD@225057|Acidithiobacillales	225057|Acidithiobacillales	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_13139_1	572477.Alvin_1108	2.37e-119	349.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,1WWXT@135613|Chromatiales	135613|Chromatiales	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_536519_2	314278.NB231_10693	2.28e-65	210.0	COG0697@1|root,COG0697@2|Bacteria,1RJFE@1224|Proteobacteria,1RZF0@1236|Gammaproteobacteria,1WWYW@135613|Chromatiales	135613|Chromatiales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1066941_1	323261.Noc_2559	1.89e-41	157.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM NADH-quinone oxidoreductase, chain G	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_892343_1	243233.MCA3076	2.81e-95	295.0	COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,1RP5U@1236|Gammaproteobacteria,1XEHX@135618|Methylococcales	135618|Methylococcales	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_1534145_2	522306.CAP2UW1_4252	6.3e-34	128.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2VXAW@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_1303549_1	76114.ebA6535	7.05e-27	103.0	COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,2VRXM@28216|Betaproteobacteria,2KYQK@206389|Rhodocyclales	206389|Rhodocyclales	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
k59_1303549_2	1198232.CYCME_0186	1.2e-13	69.7	COG3663@1|root,COG3663@2|Bacteria,1RAVZ@1224|Proteobacteria,1S2GN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells	mug	-	3.2.2.28	ko:K03649	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_1477441_1	1157637.KB892110_gene4250	5.62e-130	391.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria	201174|Actinobacteria	P	Sulfate transporter	-	GO:0000103,GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006790,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008152,GO:0008272,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0017076,GO:0019001,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0097159,GO:0098656,GO:0098660,GO:0098661,GO:1901265,GO:1901363,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1242432_1	1173028.ANKO01000018_gene1193	4.49e-112	330.0	COG0153@1|root,COG0153@2|Bacteria,1G2KU@1117|Cyanobacteria,1HA2U@1150|Oscillatoriales	1117|Cyanobacteria	H	GHMP kinases N terminal domain	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_N
k59_1243376_2	1280706.AUJE01000060_gene305	2.16e-24	97.8	COG2109@1|root,COG2109@2|Bacteria,1V70U@1239|Firmicutes,4H4HZ@909932|Negativicutes	909932|Negativicutes	H	cob(I)yrinic acid a,c-diamide adenosyltransferase	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
k59_71595_1	1163617.SCD_n00589	4.22e-66	209.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2VJPI@28216|Betaproteobacteria	28216|Betaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_1005529_1	439496.RBY4I_975	1.02e-101	306.0	COG3666@1|root,COG3666@2|Bacteria,1QW5T@1224|Proteobacteria,2TWNW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase and inactivated derivatives	tnp*	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1183207_1	589865.DaAHT2_1452	3.8e-57	185.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,42NV2@68525|delta/epsilon subdivisions,2WNJ1@28221|Deltaproteobacteria,2MJKX@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_830619_1	1504319.GM45_4145	9.89e-165	471.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,3UWD5@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_713465_1	926560.KE387023_gene3658	4.43e-73	228.0	COG0500@1|root,COG2226@2|Bacteria,1WMEJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_595643_1	686340.Metal_3622	6.09e-30	113.0	2EAFX@1|root,334J9@2|Bacteria,1R3G6@1224|Proteobacteria,1TGY3@1236|Gammaproteobacteria,1XGX5@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_544129_5	1380391.JIAS01000012_gene4558	1.41e-11	73.6	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2TRU2@28211|Alphaproteobacteria,2JPMY@204441|Rhodospirillales	204441|Rhodospirillales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
k59_544129_6	180281.CPCC7001_2036	1.24e-69	249.0	COG0210@1|root,COG0210@2|Bacteria,1G17G@1117|Cyanobacteria,22RWZ@167375|Cyanobium	1117|Cyanobacteria	L	DNA helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_544129_9	186497.PF0212	2.5e-23	111.0	COG0417@1|root,arCOG00328@2157|Archaea,2XU1K@28890|Euryarchaeota,242Z2@183968|Thermococci	183968|Thermococci	L	DNA polymerase	pol	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1,Intein_splicing,LAGLIDADG_3
k59_81585_1	1245471.PCA10_55690	3.3e-49	179.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1YE43@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	czcA	-	-	ko:K18138,ko:K18303	ko01501,ko01503,map01501,map01503	M00642,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.17	-	-	ACR_tran
k59_1842738_1	85643.Tmz1t_3892	8.32e-122	366.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VZHX@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1660441_1	335543.Sfum_3071	1.81e-68	216.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,42M2I@68525|delta/epsilon subdivisions,2WMSH@28221|Deltaproteobacteria,2MQBV@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_662162_1	156889.Mmc1_2110	2.11e-76	241.0	COG1453@1|root,COG1453@2|Bacteria,1RAU3@1224|Proteobacteria	1224|Proteobacteria	S	PFAM aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red
k59_426669_1	367299.JOEE01000001_gene1882	6.42e-80	249.0	COG3275@1|root,COG3275@2|Bacteria,2GJD4@201174|Actinobacteria,4FE5E@85021|Intrasporangiaceae	201174|Actinobacteria	T	Signal transduction histidine kinase	-	-	2.7.13.3	ko:K02478	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,HATPase_c,His_kinase
k59_1078949_1	525897.Dbac_1089	3.99e-41	144.0	2E9FY@1|root,333P7@2|Bacteria,1N8S6@1224|Proteobacteria,42XWP@68525|delta/epsilon subdivisions,2WSIE@28221|Deltaproteobacteria,2MFM6@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1129185_1	1307761.L21SP2_1019	9.31e-64	214.0	COG0010@1|root,COG3457@1|root,COG0010@2|Bacteria,COG3457@2|Bacteria,2JA1N@203691|Spirochaetes	203691|Spirochaetes	E	Alanine racemase, N-terminal domain	-	-	5.1.1.12	ko:K21898	ko00472,map00472	-	R00672	RC00302	ko00000,ko00001,ko01000	-	-	-	Ala_racemase_N
k59_1717887_1	1121448.DGI_1591	3.2e-08	60.5	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,42NUT@68525|delta/epsilon subdivisions,2WKQX@28221|Deltaproteobacteria,2M80N@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_1776369_1	1121943.KB900003_gene2829	3.51e-28	116.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1XH8T@135619|Oceanospirillales	135619|Oceanospirillales	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_1541959_1	189753.AXAS01000020_gene1688	1.2e-53	184.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,3JQQI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Belongs to the peptidase S1C family	MA20_07235	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_375175_1	1255043.TVNIR_0489	1.43e-17	79.7	COG4314@1|root,COG4314@2|Bacteria,1RID8@1224|Proteobacteria	1224|Proteobacteria	C	NosL	-	-	-	-	-	-	-	-	-	-	-	-	NosL
k59_375175_2	179408.Osc7112_1949	1.19e-05	48.9	COG2836@1|root,COG2836@2|Bacteria,1G2RF@1117|Cyanobacteria,1H7WZ@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Ferric reductase like transmembrane component	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2,Ferric_reduct
k59_1314571_1	1268237.G114_01689	3.62e-09	57.8	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1Y3YG@135624|Aeromonadales	135624|Aeromonadales	J	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
k59_1314571_2	981384.AEYW01000001_gene1580	2.95e-44	150.0	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,2TUNB@28211|Alphaproteobacteria,4ND6Y@97050|Ruegeria	28211|Alphaproteobacteria	Q	Isochorismatase family	-	-	3.5.1.110	ko:K09020	ko00240,ko01100,map00240,map01100	-	R09947,R09980	RC02737,RC02738	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
k59_962405_1	582899.Hden_2309	3.32e-70	237.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,3N6H7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	PD-(D/E)XK nuclease superfamily	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
k59_1600268_1	1396418.BATQ01000160_gene4912	6.18e-67	224.0	COG3547@1|root,COG3547@2|Bacteria,46WNP@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1253082_1	667014.Thein_0970	6.19e-73	234.0	COG0107@1|root,COG0118@1|root,COG0107@2|Bacteria,COG0118@2|Bacteria,2GGYN@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K01663,ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase,His_biosynth
k59_1488016_1	384765.SIAM614_28831	7.97e-105	317.0	COG5361@1|root,COG5361@2|Bacteria,1MX31@1224|Proteobacteria,2UNXG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_776432_1	1037409.BJ6T_79390	2.49e-85	269.0	COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria,2TRKA@28211|Alphaproteobacteria,3JSZG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_776432_2	158500.BV97_05778	2.41e-125	363.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,2K38A@204457|Sphingomonadales	204457|Sphingomonadales	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_720805_1	598467.BrE312_0277	1.52e-112	333.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_4275,iECH74115_1262.ECH74115_5243,iECIAI1_1343.ECIAI1_3991,iECO103_1326.ECO103_4362,iECO111_1330.ECO111_4628,iECO26_1355.ECO26_4784,iECSE_1348.ECSE_4086,iEKO11_1354.EKO11_4554,iPC815.YPO3849	Porphobil_deam,Porphobil_deamC
k59_376313_1	504832.OCAR_7157	2.67e-106	322.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2TR0F@28211|Alphaproteobacteria,3JV0H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	D-isomer specific 2-hydroxyacid dehydrogenase	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_1718675_1	545276.KB898727_gene453	2.76e-80	263.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales	135613|Chromatiales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_1488990_1	204773.HEAR2616	6.27e-48	169.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,4739P@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Peptidase family M48	yggG_1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
k59_26539_1	1207075.PputUW4_02305	1.29e-81	255.0	28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1329
k59_963567_1	670307.HYPDE_34038	1.57e-94	289.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TSCR@28211|Alphaproteobacteria,3N6E8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_1129879_1	666685.R2APBS1_2365	4.17e-83	259.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1X3DM@135614|Xanthomonadales	135614|Xanthomonadales	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
k59_1129879_2	765912.Thimo_3378	1.49e-100	310.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1WW89@135613|Chromatiales	135613|Chromatiales	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
k59_721557_1	247633.GP2143_16596	4.7e-59	189.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,1RPYV@1236|Gammaproteobacteria,1J4ZS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	GO:0000287,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009157,GO:0009162,GO:0009165,GO:0009176,GO:0009177,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032259,GO:0034641,GO:0034654,GO:0042083,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046073,GO:0046385,GO:0046483,GO:0046872,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2827,iAPECO1_1312.APECO1_3678,iBWG_1329.BWG_2562,iE2348C_1286.E2348C_3096,iEC042_1314.EC042_3024,iEC55989_1330.EC55989_3103,iECABU_c1320.ECABU_c31240,iECDH10B_1368.ECDH10B_2997,iECDH1ME8569_1439.ECDH1ME8569_2734,iECED1_1282.ECED1_3283,iECH74115_1262.ECH74115_4093,iECIAI1_1343.ECIAI1_2935,iECIAI39_1322.ECIAI39_3246,iECNA114_1301.ECNA114_2885,iECO103_1326.ECO103_3386,iECO111_1330.ECO111_3555,iECO26_1355.ECO26_3899,iECOK1_1307.ECOK1_3231,iECP_1309.ECP_2840,iECS88_1305.ECS88_3122,iECSE_1348.ECSE_3084,iECSF_1327.ECSF_2642,iECSP_1301.ECSP_3779,iECUMN_1333.ECUMN_3154,iECW_1372.ECW_m3069,iECs_1301.ECs3684,iEKO11_1354.EKO11_0914,iETEC_1333.ETEC_3014,iEcDH1_1363.EcDH1_0864,iEcE24377_1341.EcE24377A_3147,iEcSMS35_1347.EcSMS35_2974,iG2583_1286.G2583_3481,iJO1366.b2827,iJR904.b2827,iLF82_1304.LF82_2267,iNRG857_1313.NRG857_13965,iSSON_1240.SSON_2984,iUMN146_1321.UM146_02290,iUMNK88_1353.UMNK88_3511,iUTI89_1310.UTI89_C3229,iWFL_1372.ECW_m3069,iY75_1357.Y75_RS14705,iYL1228.KPN_03236,iZ_1308.Z4144,ic_1306.c3422	Thymidylat_synt
k59_721557_2	1121937.AUHJ01000010_gene1660	1.65e-37	134.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,4655B@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009898,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_1777182_1	1120792.JAFV01000001_gene3898	2.15e-86	270.0	COG0747@1|root,COG0747@2|Bacteria,1MWR7@1224|Proteobacteria,2TS51@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC-type dipeptide transport system periplasmic component	MA20_22710	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5,TAT_signal
k59_1191398_1	288705.RSal33209_2644	2.61e-30	120.0	COG4948@1|root,COG4948@2|Bacteria,2GJJR@201174|Actinobacteria,1W7Y6@1268|Micrococcaceae	201174|Actinobacteria	M	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	GO:0008150,GO:0040007	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0553	MR_MLE_C
k59_904573_1	314285.KT71_02627	5.07e-32	130.0	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S0KQ@1236|Gammaproteobacteria,1J82F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1488997_1	1209984.BN978_04815	1.48e-56	201.0	COG3299@1|root,COG3299@2|Bacteria	2|Bacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
k59_1426408_1	1304865.JAGF01000001_gene2951	4.56e-52	178.0	COG0327@1|root,COG0327@2|Bacteria,2GKHZ@201174|Actinobacteria,4F0E5@85016|Cellulomonadaceae	201174|Actinobacteria	S	Belongs to the GTP cyclohydrolase I type 2 NIF3 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	NIF3
k59_134677_1	765911.Thivi_1112	1.43e-74	240.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1WWGN@135613|Chromatiales	135613|Chromatiales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_838695_1	391625.PPSIR1_12378	1.29e-19	85.1	COG2343@1|root,COG2343@2|Bacteria,1RJ3M@1224|Proteobacteria,435H4@68525|delta/epsilon subdivisions,2X99Q@28221|Deltaproteobacteria,2Z2SQ@29|Myxococcales	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
k59_838695_2	743718.Isova_1640	7.42e-137	402.0	COG0124@1|root,COG0124@2|Bacteria,2GIYJ@201174|Actinobacteria,4F3PX@85017|Promicromonosporaceae	201174|Actinobacteria	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_1777184_1	552811.Dehly_0447	3.1e-132	386.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,2G8GQ@200795|Chloroflexi,34DDP@301297|Dehalococcoidia	301297|Dehalococcoidia	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_1426412_1	1205753.A989_01040	2.09e-30	124.0	COG1164@1|root,COG1164@2|Bacteria,1MWYN@1224|Proteobacteria,1RS2Q@1236|Gammaproteobacteria,1X3UN@135614|Xanthomonadales	135614|Xanthomonadales	E	Angiotensin-converting enzyme	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
k59_26559_1	2340.JV46_22740	4.48e-69	213.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria,1J6C3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046983,GO:0070037,GO:0070038,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
k59_1777185_1	223926.28806081	5.59e-10	60.5	COG0679@1|root,COG0679@2|Bacteria,1N1X9@1224|Proteobacteria,1RMV0@1236|Gammaproteobacteria,1XSDV@135623|Vibrionales	135623|Vibrionales	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
k59_1777185_2	1121033.AUCF01000024_gene212	7.58e-11	60.8	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,2TUNB@28211|Alphaproteobacteria,2JQY6@204441|Rhodospirillales	204441|Rhodospirillales	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_486256_1	1713.JOFV01000010_gene1148	6.42e-149	441.0	COG3957@1|root,COG3957@2|Bacteria,2GN27@201174|Actinobacteria,4F0XD@85016|Cellulomonadaceae	201174|Actinobacteria	G	PFAM Xylulose 5-phosphate Fructose 6-phosphate phosphoketolase-like	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
k59_838705_1	1267005.KB911257_gene914	5.25e-159	476.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2TS8V@28211|Alphaproteobacteria,3N6G9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	FtsX-like permease family	MA20_43810	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_82788_1	349521.HCH_05919	8.76e-20	85.9	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,1RNV4@1236|Gammaproteobacteria,1XJ9Q@135619|Oceanospirillales	135619|Oceanospirillales	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
k59_82788_2	1415778.JQMM01000001_gene281	4.29e-08	54.7	COG0428@1|root,COG0428@2|Bacteria,1R40E@1224|Proteobacteria,1RRYS@1236|Gammaproteobacteria,1J6RV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	ZIP Zinc transporter	-	-	-	ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11	-	-	Zip
k59_1542793_1	652103.Rpdx1_4679	2.56e-08	55.5	COG2020@1|root,COG2020@2|Bacteria,1MZ7S@1224|Proteobacteria,2UCNU@28211|Alphaproteobacteria,3K13F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_26588_1	58123.JOFJ01000003_gene1996	1.38e-54	189.0	COG0160@1|root,COG0160@2|Bacteria,2GKVH@201174|Actinobacteria,4EGMW@85012|Streptosporangiales	201174|Actinobacteria	E	Aminotransferase class-III	-	-	1.2.1.18,1.2.1.27,2.6.1.19	ko:K00140,ko:K00823	ko00250,ko00280,ko00410,ko00562,ko00640,ko00650,ko01100,ko01120,ko01200,map00250,map00280,map00410,map00562,map00640,map00650,map01100,map01120,map01200	M00013,M00027	R00705,R00706,R00908,R00922,R00935,R01648	RC00004,RC00006,RC00062,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1542794_1	1286106.MPL1_12191	1.7e-30	113.0	COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,1S402@1236|Gammaproteobacteria,460SP@72273|Thiotrichales	72273|Thiotrichales	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
k59_486276_1	95619.PM1_0209975	6.72e-25	107.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1S358@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	COG4235 Cytochrome c biogenesis factor	cycH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_2
k59_427519_1	1121405.dsmv_2224	1.38e-67	230.0	COG0577@1|root,COG2234@1|root,COG0577@2|Bacteria,COG2234@2|Bacteria,1MVYE@1224|Proteobacteria,42PKN@68525|delta/epsilon subdivisions,2WIWP@28221|Deltaproteobacteria,2MIQI@213118|Desulfobacterales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,PA,Peptidase_M28
k59_1366885_1	870187.Thini_1237	9.26e-90	276.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria,45ZTP@72273|Thiotrichales	72273|Thiotrichales	S	Flavocytochrome c sulphide dehydrogenase, flavin-binding	-	-	1.8.2.3	ko:K17229	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2
k59_1426445_1	367299.JOEE01000004_gene1066	6.53e-142	421.0	COG0272@1|root,COG0272@2|Bacteria,2GJUY@201174|Actinobacteria,4FE3B@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
k59_1315808_1	1182553.XP_007740092.1	1.72e-09	64.7	COG1132@1|root,KOG0055@2759|Eukaryota,39W4T@33154|Opisthokonta,3NZ4A@4751|Fungi,3QQN8@4890|Ascomycota,20AEX@147545|Eurotiomycetes	4751|Fungi	Q	Multidrug resistance protein	-	-	3.6.3.44	ko:K05658	ko02010,ko04976,ko05206,ko05226,map02010,map04976,map05206,map05226	-	-	-	ko00000,ko00001,ko01000,ko02000,ko04090,ko04147	3.A.1.201	-	-	ABC_membrane,ABC_tran
k59_82818_1	1280953.HOC_07314	1.82e-64	213.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2TQMA@28211|Alphaproteobacteria,43X3X@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	COG1271 Cytochrome bd-type quinol oxidase, subunit 1	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_310208_1	1158756.AQXQ01000012_gene2038	4.72e-51	175.0	COG0540@1|root,COG0540@2|Bacteria,1R3Q5@1224|Proteobacteria,1RYCN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the ATCase OTCase family	-	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_427528_1	1121439.dsat_0860	3.32e-08	54.3	COG0577@1|root,COG0577@2|Bacteria,1RC4T@1224|Proteobacteria,42QZ6@68525|delta/epsilon subdivisions,2WMU4@28221|Deltaproteobacteria,2MB5S@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
k59_427528_2	1322246.BN4_11999	3.58e-76	234.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,4308T@68525|delta/epsilon subdivisions,2WKJ3@28221|Deltaproteobacteria,2M84K@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	PFAM ABC transporter	lolD-2	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1844000_1	331869.BAL199_26771	2.88e-32	127.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2TRQD@28211|Alphaproteobacteria,4BQ27@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Sugar (and other) transporter	MA20_01870	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_1315813_1	891968.Anamo_2052	3.15e-26	108.0	COG1489@1|root,COG1833@1|root,COG1489@2|Bacteria,COG1833@2|Bacteria,3TB3T@508458|Synergistetes	508458|Synergistetes	S	Belongs to the SfsA family	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	DUF123,SfsA
k59_26619_1	367299.JOEE01000003_gene2861	1.55e-35	123.0	COG0234@1|root,COG0234@2|Bacteria,2IHRC@201174|Actinobacteria,4FH47@85021|Intrasporangiaceae	201174|Actinobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groES2	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
k59_82821_1	1220583.GOACH_09_00110	2.23e-86	267.0	29XPH@1|root,30JF3@2|Bacteria,2GRCU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_603423_1	1123400.KB904768_gene3402	7.15e-114	338.0	COG1910@1|root,COG1910@2|Bacteria,1MVS4@1224|Proteobacteria,1RY8Q@1236|Gammaproteobacteria,463K2@72273|Thiotrichales	72273|Thiotrichales	P	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,PBP_like
k59_963642_1	768671.ThimaDRAFT_1458	6.82e-130	381.0	COG2304@1|root,COG2304@2|Bacteria,1N2UU@1224|Proteobacteria,1RXGJ@1236|Gammaproteobacteria,1WX7E@135613|Chromatiales	135613|Chromatiales	S	von Willebrand factor, type A	-	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	VWA_2
k59_662992_1	582899.Hden_3169	5.07e-122	361.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2TVZH@28211|Alphaproteobacteria,3N81A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Transporter associated domain	corB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_1601089_1	29730.Gorai.004G270500.1	2.58e-17	78.2	COG0229@1|root,KOG0856@2759|Eukaryota,37I4S@33090|Viridiplantae,3GE85@35493|Streptophyta	35493|Streptophyta	O	methionine sulfoxide reductase	MSRB1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0016491,GO:0016667,GO:0016671,GO:0033743,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0050896,GO:0055114	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
k59_1661333_1	522306.CAP2UW1_2531	2.9e-19	86.7	COG3198@1|root,COG3198@2|Bacteria,1N75J@1224|Proteobacteria,2VTYE@28216|Betaproteobacteria	28216|Betaproteobacteria	S	FixH	-	-	-	ko:K09926	-	-	-	-	ko00000	-	-	-	FixH
k59_1661333_2	1348114.OM33_10205	5.98e-11	62.8	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,2Q19B@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	P	Cation transport ATPase	ccoI	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_310220_1	411466.ACTODO_02207	1.09e-35	131.0	COG0313@1|root,COG0313@2|Bacteria,2GJ9Q@201174|Actinobacteria,4D4DW@85005|Actinomycetales	201174|Actinobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_1718756_1	1408303.JNJJ01000045_gene1118	3.2e-35	135.0	COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,4H9YC@91061|Bacilli,1ZB8H@1386|Bacillus	91061|Bacilli	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
k59_1191460_1	1304865.JAGF01000001_gene1528	1.49e-18	86.3	COG5002@1|root,COG5002@2|Bacteria,2I3U8@201174|Actinobacteria	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_1542819_1	1255043.TVNIR_3399	4.05e-39	142.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,1RNZZ@1236|Gammaproteobacteria,1WWGF@135613|Chromatiales	135613|Chromatiales	F	PFAM AIR synthase related protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_1542819_2	396588.Tgr7_2254	2.11e-86	262.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,1RMHS@1236|Gammaproteobacteria,1WY1C@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
k59_1542819_3	754476.Q7A_2065	1.55e-34	130.0	COG3170@1|root,COG3170@2|Bacteria,1RDXQ@1224|Proteobacteria,1T42I@1236|Gammaproteobacteria,460XW@72273|Thiotrichales	72273|Thiotrichales	NU	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
k59_963659_1	644107.SL1157_3194	1.26e-125	384.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2TTPX@28211|Alphaproteobacteria,4NANY@97050|Ruegeria	28211|Alphaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdhF	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1718759_1	1417296.U879_08365	1.41e-76	242.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQNK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1087891_1	1163617.SCD_n01500	4.92e-76	251.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_1372723_1	1397278.AYMV01000007_gene257	6.22e-16	87.4	COG1277@1|root,COG1277@2|Bacteria,2ID14@201174|Actinobacteria,4FTTD@85023|Microbacteriaceae	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_1135799_1	425104.Ssed_2951	4.82e-63	213.0	COG1922@1|root,COG2148@1|root,COG1922@2|Bacteria,COG2148@2|Bacteria,1N1HD@1224|Proteobacteria,1RP6P@1236|Gammaproteobacteria,2QAQA@267890|Shewanellaceae	1236|Gammaproteobacteria	M	TIGRFAM glycosyl transferase, WecB TagA CpsF family	gumM	-	2.4.1.187	ko:K05946,ko:K13660	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Bac_transf,Glyco_tran_WecB
k59_385751_1	1504672.669783332	2.72e-36	140.0	COG0586@1|root,COG0671@1|root,COG0586@2|Bacteria,COG0671@2|Bacteria,1R0F3@1224|Proteobacteria,2VQN3@28216|Betaproteobacteria,4AJY0@80864|Comamonadaceae	28216|Betaproteobacteria	I	PAP2 superfamily	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	LssY_C,PAP2,SNARE_assoc
k59_1432754_1	1121405.dsmv_2227	1.83e-86	275.0	28HQ2@1|root,2Z7XV@2|Bacteria,1P4Z7@1224|Proteobacteria,42NSG@68525|delta/epsilon subdivisions,2WJ6K@28221|Deltaproteobacteria,2MJCF@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_316618_1	1121405.dsmv_1099	6.89e-119	347.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42N06@68525|delta/epsilon subdivisions,2WK5N@28221|Deltaproteobacteria,2MMZ0@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Transketolase, pyrimidine binding domain	bkdB	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K00167	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_551023_1	1123070.KB899249_gene281	1.72e-50	176.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,46VPA@74201|Verrucomicrobia,2IW7I@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	TrkA-N domain	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
k59_1783130_1	2340.JV46_13300	3.41e-68	232.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J582@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18989	-	M00720	-	-	ko00000,ko00002,ko02000	2.A.6.2.30	-	-	ACR_tran
k59_37069_1	324602.Caur_1461	7.56e-68	216.0	COG0183@1|root,COG0183@2|Bacteria,2GAQ4@200795|Chloroflexi,3770V@32061|Chloroflexia	32061|Chloroflexia	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1496537_1	1121439.dsat_0639	7.38e-44	160.0	COG0243@1|root,COG0243@2|Bacteria,1R5ZE@1224|Proteobacteria,42QK1@68525|delta/epsilon subdivisions,2WPX8@28221|Deltaproteobacteria,2MEF8@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_1725045_1	1249627.D779_0228	9.9e-123	369.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_1725045_2	396588.Tgr7_2065	1.68e-49	168.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1WX0P@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_1853592_1	517417.Cpar_0333	1.91e-06	49.3	COG2170@1|root,COG2170@2|Bacteria,1FEUU@1090|Chlorobi	1090|Chlorobi	S	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1853592_2	1249627.D779_3881	7.02e-97	288.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,1S23A@1236|Gammaproteobacteria,1WWYC@135613|Chromatiales	135613|Chromatiales	JM	PFAM Nucleotidyl transferase	-	-	2.7.7.99	ko:K00992	ko00520,ko01100,map00520,map01100	-	R11025	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
k59_1853592_3	572477.Alvin_0409	1.59e-124	367.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1WWRK@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
k59_551033_1	1121937.AUHJ01000026_gene38	5.34e-137	398.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria,464M3@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Transposase, Mutator family	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_1853598_2	765911.Thivi_4240	3.1e-67	210.0	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,1RNF8@1236|Gammaproteobacteria,1WVVE@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
k59_1853599_1	1191523.MROS_1561	7.07e-22	97.8	COG0111@1|root,COG0111@2|Bacteria	2|Bacteria	EH	4-phosphoerythronate dehydrogenase activity	pdxB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0033711,GO:0034641,GO:0036001,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.1.1.290	ko:K03473	ko00750,ko01100,map00750,map01100	M00124	R04210	RC00084	ko00000,ko00001,ko00002,ko01000	-	-	iZ_1308.Z3582	2-Hacid_dh,2-Hacid_dh_C,DUF3410
k59_385787_1	395493.BegalDRAFT_2551	6.8e-92	285.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,45ZVD@72273|Thiotrichales	72273|Thiotrichales	E	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_609736_1	1043493.BBLU01000002_gene1760	8.61e-46	157.0	arCOG07533@1|root,2ZF5I@2|Bacteria,2IMPX@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
k59_140728_1	391615.ABSJ01000032_gene722	2.18e-16	81.6	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Peptidoglycan polymerase that is essential for cell division	ftsW	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_140728_2	187272.Mlg_2195	5.33e-67	218.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1WWI1@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_1725059_1	367299.JOEE01000002_gene2229	2.05e-99	297.0	COG0702@1|root,COG0702@2|Bacteria,2GIZA@201174|Actinobacteria,4FED9@85021|Intrasporangiaceae	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
k59_1783143_2	1123401.JHYQ01000007_gene542	2.31e-254	724.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,461JN@72273|Thiotrichales	72273|Thiotrichales	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_844926_1	335543.Sfum_2902	4.53e-54	177.0	COG0688@1|root,COG0688@2|Bacteria,1NNH6@1224|Proteobacteria,42YJ1@68525|delta/epsilon subdivisions,2WTZP@28221|Deltaproteobacteria,2MR4E@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Phosphatidylserine decarboxylase	-	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
k59_1853624_1	471853.Bcav_3287	0.000169	43.9	COG1246@1|root,COG1246@2|Bacteria,2GJBT@201174|Actinobacteria	201174|Actinobacteria	E	N-acetylglutamate synthase	argA	GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
k59_1853624_2	446469.Sked_06830	2.4e-35	130.0	COG2390@1|root,COG2390@2|Bacteria,2GMIM@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	ko:K05346	-	-	-	-	ko00000,ko03000	-	-	-	HTH_23,HTH_28,MarR_2,Sigma70_r4,Sugar-bind
k59_973148_1	1122611.KB903940_gene2055	7.19e-142	431.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4EGTA@85012|Streptosporangiales	201174|Actinobacteria	P	Cation transporter/ATPase, N-terminus	ctpF	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.8	ko:K01537,ko:K12953	-	-	-	-	ko00000,ko01000	3.A.3,3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_609743_1	177437.HRM2_10690	1.83e-96	290.0	COG0674@1|root,COG0674@2|Bacteria,1MWCI@1224|Proteobacteria,42NJY@68525|delta/epsilon subdivisions,2WIW3@28221|Deltaproteobacteria,2MHPN@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	vorA	-	1.2.7.11,1.2.7.3,1.2.7.7	ko:K00174,ko:K00186	ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197,R07160,R08566,R08567	RC00004,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1307	PFOR_II,POR_N
k59_914148_1	335543.Sfum_1711	2.09e-40	144.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,42M15@68525|delta/epsilon subdivisions,2WIQN@28221|Deltaproteobacteria,2MQ9T@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_551055_1	1713.JOFV01000002_gene579	1.64e-51	171.0	COG1216@1|root,COG1216@2|Bacteria,2GMQQ@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
k59_385831_1	768671.ThimaDRAFT_1328	3.63e-98	305.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1X0QV@135613|Chromatiales	135613|Chromatiales	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_1496572_1	640081.Dsui_3442	5.26e-120	353.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,2VKI2@28216|Betaproteobacteria,2KX65@206389|Rhodocyclales	206389|Rhodocyclales	S	FAD-dependent pyridine nucleotide-disulfide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_140746_1	1165096.ARWF01000001_gene2210	4.21e-21	96.7	COG0607@1|root,COG2905@1|root,COG0607@2|Bacteria,COG2905@2|Bacteria,1R9Q1@1224|Proteobacteria,2VQGZ@28216|Betaproteobacteria,2KNP5@206350|Nitrosomonadales	206350|Nitrosomonadales	PT	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,cNMP_binding
k59_551060_1	1122599.AUGR01000025_gene1468	9.98e-53	184.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,1XIPX@135619|Oceanospirillales	135619|Oceanospirillales	S	mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_92391_1	1300345.LF41_3143	4.03e-90	279.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1X393@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	-	-	-	-	-	-	-	-	-	-	PALP
k59_1853657_1	159450.NH14_22810	2.26e-47	161.0	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,2VQNZ@28216|Betaproteobacteria,1K1BD@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM cytochrome c, class I	cyc	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_199311_2	519989.ECTPHS_05040	1.6e-35	127.0	COG3151@1|root,COG3151@2|Bacteria,1NAPI@1224|Proteobacteria,1SEY8@1236|Gammaproteobacteria,1WYT2@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1249)	-	-	-	ko:K09920	-	-	-	-	ko00000	-	-	-	DUF1249
k59_199311_3	1112217.PPL19_15584	2.43e-35	132.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Fad linked oxidase	glcD	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	iJN746.PP_3745,iLF82_1304.LF82_0831,iNRG857_1313.NRG857_14750	FAD-oxidase_C,FAD_binding_4
k59_1372783_1	880072.Desac_1450	2.61e-88	264.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,42N5W@68525|delta/epsilon subdivisions,2WIU3@28221|Deltaproteobacteria,2MQ8I@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_92402_1	1282356.H045_21915	4.66e-59	188.0	COG1462@1|root,COG1462@2|Bacteria,1NDU8@1224|Proteobacteria,1RPPY@1236|Gammaproteobacteria,1YPTT@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	M	Curli production assembly	csgG	-	-	-	-	-	-	-	-	-	-	-	CsgG
k59_844951_1	584708.Apau_0079	1.89e-19	91.7	COG0845@1|root,COG0845@2|Bacteria,3T9UB@508458|Synergistetes	508458|Synergistetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
k59_92406_1	1304865.JAGF01000001_gene933	2.89e-178	509.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4F0I7@85016|Cellulomonadaceae	201174|Actinobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0008150,GO:0040007	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
k59_1853667_1	102129.Lepto7375DRAFT_0024	1.51e-28	121.0	COG4252@1|root,COG4252@2|Bacteria,1G1KA@1117|Cyanobacteria,1H888@1150|Oscillatoriales	1117|Cyanobacteria	T	transmembrane sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,CHAT
k59_1197768_1	309807.SRU_0538	4.58e-28	120.0	COG0210@1|root,COG0210@2|Bacteria,4NDWN@976|Bacteroidetes,1FIWU@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1087966_1	1279017.AQYJ01000022_gene2613	1.6e-63	214.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVS@1236|Gammaproteobacteria,46674@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA
k59_973199_1	640081.Dsui_3430	2.23e-116	363.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,2KVY2@206389|Rhodocyclales	206389|Rhodocyclales	P	AcrB/AcrD/AcrF family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
k59_1135855_1	713587.THITH_08145	1.26e-113	332.0	COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,1RREE@1236|Gammaproteobacteria,1WWMU@135613|Chromatiales	135613|Chromatiales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_92419_1	420662.Mpe_A1787	1.01e-30	111.0	COG4274@1|root,COG4274@2|Bacteria,1RHJ3@1224|Proteobacteria,2VXBZ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
k59_609768_1	2340.JV46_19120	3.44e-84	261.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1JBG6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cysteine-rich domain	dgcB	-	-	ko:K21834	-	-	-	-	ko00000	-	-	-	CCG,DUF3483,Fer4_8
k59_609768_2	1417296.U879_20705	2.93e-73	228.0	COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,2UIT4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	nitrate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1432811_1	590998.Celf_1386	8.8e-21	94.0	COG0699@1|root,COG0699@2|Bacteria,2GM68@201174|Actinobacteria,4F0FD@85016|Cellulomonadaceae	201174|Actinobacteria	S	50S ribosome-binding GTPase	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N,MMR_HSR1
k59_1372799_1	1041159.AZUW01000008_gene4169	2.48e-73	240.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2TS9R@28211|Alphaproteobacteria,4B7DW@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	glcB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_782558_1	323848.Nmul_A2472	1.8e-48	168.0	COG1752@1|root,COG1752@2|Bacteria,1PIHH@1224|Proteobacteria,2VHKX@28216|Betaproteobacteria,3722R@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_1197776_1	439235.Dalk_3266	2.37e-100	325.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_1783178_2	926550.CLDAP_26090	1.71e-81	246.0	COG3335@1|root,COG3335@2|Bacteria,2G9N4@200795|Chloroflexi	200795|Chloroflexi	L	IS630 family ISRj1-like transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_92434_1	1049564.TevJSym_aw00630	9.12e-21	96.3	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J4C2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	ykoW	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9
k59_1725109_1	471853.Bcav_2151	7.75e-95	291.0	COG0287@1|root,COG0287@2|Bacteria,2GKB4@201174|Actinobacteria	201174|Actinobacteria	E	Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
k59_1549361_1	926692.AZYG01000016_gene590	1.1e-48	172.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1TQNH@1239|Firmicutes,2487I@186801|Clostridia,3WB33@53433|Halanaerobiales	186801|Clostridia	H	Belongs to the precorrin methyltransferase family	cobA	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15755	HEM4,Porphobil_deam,Porphobil_deamC,TP_methylase
k59_1549361_2	706587.Desti_2617	2.38e-38	144.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2MQD2@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	PFAM UvrD REP helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_271601_1	990285.RGCCGE502_15820	4.65e-31	124.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,2TVUJ@28211|Alphaproteobacteria,4BB1J@82115|Rhizobiaceae	28211|Alphaproteobacteria	CP	NADH dehydrogenase I, subunit N related protein	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_1497410_2	768671.ThimaDRAFT_2385	5.99e-68	208.0	COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria,1WY9X@135613|Chromatiales	135613|Chromatiales	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
k59_1549367_1	990285.RGCCGE502_10416	8.38e-21	89.0	COG1853@1|root,COG1853@2|Bacteria,1RHHD@1224|Proteobacteria,2UB9E@28211|Alphaproteobacteria,4BEXM@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	4-hydroxyphenylacetate 3-monooxygenase	nmoB	-	1.16.8.1	ko:K13786	ko00860,ko01100,map00860,map01100	-	R05218	RC01010	ko00000,ko00001,ko01000	-	-	-	Flavin_Reduct
k59_1549367_2	96561.Dole_1725	1.06e-24	96.7	COG0216@1|root,COG0216@2|Bacteria,1R348@1224|Proteobacteria,43DJ0@68525|delta/epsilon subdivisions,2X8QA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	PFAM Class I peptide chain release factor	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
k59_317415_1	929506.CbC4_2134	4.09e-117	347.0	COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,2481T@186801|Clostridia,36EA3@31979|Clostridiaceae	186801|Clostridia	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_551831_1	1249627.D779_3884	3.36e-79	242.0	COG4322@1|root,COG4322@2|Bacteria,1R4WQ@1224|Proteobacteria,1SZ11@1236|Gammaproteobacteria,1WX5W@135613|Chromatiales	135613|Chromatiales	S	Uncharacterized protein conserved in bacteria (DUF2272)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2272
k59_551831_2	983548.Krodi_2834	1.01e-21	94.4	COG0366@1|root,COG0366@2|Bacteria,4NIGP@976|Bacteroidetes,1I061@117743|Flavobacteriia,37EKE@326319|Dokdonia	976|Bacteroidetes	G	Alpha amylase catalytic	-	-	2.4.1.7	ko:K00690	ko00500,map00500	-	R00803	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
k59_199998_1	1121439.dsat_0858	2.17e-79	266.0	COG0577@1|root,COG2234@1|root,COG0577@2|Bacteria,COG2234@2|Bacteria,1MVYE@1224|Proteobacteria,42PKN@68525|delta/epsilon subdivisions,2WIWP@28221|Deltaproteobacteria,2M8ZJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,PA,Peptidase_M28
k59_93726_1	768671.ThimaDRAFT_1231	1.3e-95	297.0	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,1RMC2@1236|Gammaproteobacteria,1WVZ5@135613|Chromatiales	135613|Chromatiales	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	-	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
k59_1433520_1	640512.BC1003_0664	1.84e-67	220.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VZNG@28216|Betaproteobacteria,1K6IW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	similarity to GP 3192745	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1326763_1	857087.Metme_0511	2.6e-115	338.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,1RMPD@1236|Gammaproteobacteria,1XDXA@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG,ThiS
k59_324468_1	443152.MDG893_03860	2.72e-42	160.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D1@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1732862_1	1207063.P24_13568	2.5e-12	72.4	COG1167@1|root,COG1167@2|Bacteria,1R0YZ@1224|Proteobacteria,2TYV4@28211|Alphaproteobacteria,2JS8F@204441|Rhodospirillales	204441|Rhodospirillales	EK	Uncharacterized protein conserved in bacteria (DUF2066)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2066
k59_47909_1	713586.KB900536_gene2579	1.81e-43	153.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_47909_2	396588.Tgr7_0459	5.32e-12	65.9	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
k59_105759_1	933262.AXAM01000017_gene3137	3.23e-91	296.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1143@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1143@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MHRJ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	poR	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_852615_1	667014.Thein_2156	1.2e-38	147.0	COG0178@1|root,COG0178@2|Bacteria,2GGUR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_324469_1	1120999.JONM01000004_gene3470	4.32e-07	49.7	COG1943@1|root,COG1943@2|Bacteria,1RCWW@1224|Proteobacteria,2VSPX@28216|Betaproteobacteria,2KRB8@206351|Neisseriales	206351|Neisseriales	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_324469_2	1163617.SCD_n01599	7.89e-48	159.0	COG0680@1|root,COG0680@2|Bacteria,1MZE1@1224|Proteobacteria,2VTPX@28216|Betaproteobacteria	28216|Betaproteobacteria	C	hydrogenase maturation protease	hoxW	-	-	-	-	-	-	-	-	-	-	-	-
k59_324469_3	2340.JV46_10670	2.2e-35	132.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,1T20U@1236|Gammaproteobacteria,1JAKX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Nickel-dependent hydrogenase	-	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
k59_1789822_1	1380393.JHVP01000007_gene4406	2.48e-19	89.0	28QKY@1|root,2ZD2Q@2|Bacteria,2IM53@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_986797_1	999141.GME_10271	2.48e-29	110.0	COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria,1XHYH@135619|Oceanospirillales	135619|Oceanospirillales	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
k59_986797_2	396588.Tgr7_0109	6.66e-39	136.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Exodeoxyribonuclease III	crc	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_280794_1	666681.M301_0034	1.49e-176	501.0	COG3185@1|root,COG3185@2|Bacteria,1R5AJ@1224|Proteobacteria,2W11Y@28216|Betaproteobacteria,2KKMU@206350|Nitrosomonadales	206350|Nitrosomonadales	E	4-Hydroxyphenylpyruvate dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_207256_1	446471.Xcel_2217	8.26e-111	335.0	COG0433@1|root,COG0433@2|Bacteria,2GM12@201174|Actinobacteria,4F3GJ@85017|Promicromonosporaceae	201174|Actinobacteria	S	Domain of unknown function DUF87	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
k59_105774_1	1322246.BN4_20337	0.000101	43.9	COG1055@1|root,COG1055@2|Bacteria,1QUC0@1224|Proteobacteria,42NUZ@68525|delta/epsilon subdivisions,2WJNH@28221|Deltaproteobacteria,2M9FX@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Sodium sulphate symporter	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
k59_105774_2	439235.Dalk_2249	1.49e-72	239.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MIZ@68525|delta/epsilon subdivisions,2WIUX@28221|Deltaproteobacteria,2MHR5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	CHASE5,HAMP,HATPase_c,HisKA,dCache_1,dCache_2
k59_500303_1	1125700.HMPREF9195_02283	1.94e-27	115.0	COG0285@1|root,COG0285@2|Bacteria,2J5CZ@203691|Spirochaetes	203691|Spirochaetes	H	TIGRFAM folylpolyglutamate synthase dihydrofolate synthase	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_986800_1	1229205.BUPH_08508	9.25e-92	275.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VNSH@28216|Betaproteobacteria,1KGQD@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_148698_1	1122603.ATVI01000012_gene1128	3.54e-55	183.0	COG0583@1|root,COG0583@2|Bacteria,1MZTA@1224|Proteobacteria,1RN7R@1236|Gammaproteobacteria,1X54Q@135614|Xanthomonadales	135614|Xanthomonadales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1615500_2	754477.Q7C_791	3.52e-22	98.2	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,45ZVU@72273|Thiotrichales	72273|Thiotrichales	M	PFAM AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA
k59_49489_1	713586.KB900536_gene2182	2.3e-63	204.0	COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1WW4W@135613|Chromatiales	135613|Chromatiales	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1868784_1	367299.JOEE01000003_gene2869	1.57e-53	174.0	2E4AX@1|root,32Z6K@2|Bacteria,2I0B2@201174|Actinobacteria,4FGYV@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF2017)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2017
k59_1868784_2	479433.Caci_7556	5.94e-12	64.3	COG0796@1|root,COG0796@2|Bacteria,2GN4I@201174|Actinobacteria	201174|Actinobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	GO:0000270,GO:0003674,GO:0003824,GO:0004857,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008657,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010911,GO:0016020,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0030234,GO:0032780,GO:0034645,GO:0036361,GO:0042030,GO:0042546,GO:0043086,GO:0043170,GO:0043462,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0047661,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0072586,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:2000371,GO:2000372	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
k59_325368_1	1123322.KB904682_gene4729	6.98e-13	69.3	COG1028@1|root,COG1028@2|Bacteria,2GK6C@201174|Actinobacteria	201174|Actinobacteria	IQ	reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_325368_2	1337936.IJ00_16175	3e-09	58.5	COG2366@1|root,COG2366@2|Bacteria,1G4M5@1117|Cyanobacteria,1HU4F@1161|Nostocales	1117|Cyanobacteria	S	penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_107280_1	999141.GME_11992	1.61e-71	223.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,1RMDF@1236|Gammaproteobacteria,1XIU2@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
k59_1097519_2	1279017.AQYJ01000028_gene2180	5.87e-17	78.2	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,1RPYV@1236|Gammaproteobacteria,464KC@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
k59_1271995_1	1172188.KB911828_gene4126	3.93e-22	90.9	2C4JJ@1|root,32RE3@2|Bacteria,2IKF1@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1269)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
k59_49507_1	375286.mma_2982	1.77e-24	107.0	COG4191@1|root,COG4191@2|Bacteria,1QU7R@1224|Proteobacteria,2VICU@28216|Betaproteobacteria,473E9@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	pilS	-	2.7.13.3	ko:K02668,ko:K10125	ko02020,map02020	M00501,M00504	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS_8
k59_282239_1	1121124.JNIX01000016_gene2047	6.1e-24	100.0	COG0861@1|root,COG0861@2|Bacteria,1PN8B@1224|Proteobacteria,2TUV5@28211|Alphaproteobacteria,2KF4E@204458|Caulobacterales	204458|Caulobacterales	P	PFAM Integral membrane protein TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
k59_677929_1	1120999.JONM01000008_gene2040	4.06e-35	134.0	COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria,2KQ9B@206351|Neisseriales	206351|Neisseriales	M	NlpB/DapX lipoprotein	-	-	-	ko:K07287	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	Lipoprotein_18
k59_677929_2	396588.Tgr7_0827	8.5e-114	335.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1WWMV@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_988377_1	991905.SL003B_1307	6.71e-89	290.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria,4BTG1@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Vitamin B12 dependent methionine synthase, activation domain	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_1024691_1	177437.HRM2_22100	1.89e-84	280.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2
k59_1381468_1	204669.Acid345_4117	8.13e-32	134.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
k59_442494_1	1123399.AQVE01000002_gene2374	6.43e-85	262.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,46064@72273|Thiotrichales	72273|Thiotrichales	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_1340629_1	439235.Dalk_1916	5.24e-53	167.0	COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,42SE4@68525|delta/epsilon subdivisions,2WP4K@28221|Deltaproteobacteria,2MK4M@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
k59_1340629_2	1267533.KB906735_gene5130	2.06e-17	80.5	COG0087@1|root,COG0087@2|Bacteria,3Y2H7@57723|Acidobacteria,2JI91@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_1506354_1	543632.JOJL01000027_gene2880	8.67e-28	108.0	2EC8S@1|root,33677@2|Bacteria,2GUT2@201174|Actinobacteria,4DKKZ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1506354_2	479431.Namu_4841	1.53e-05	47.8	COG4850@1|root,COG4850@2|Bacteria,2GKPS@201174|Actinobacteria,4EV8N@85013|Frankiales	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2183)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2183
k59_1868846_1	367299.JOEE01000003_gene2992	7.64e-82	262.0	COG1287@1|root,COG1287@2|Bacteria,2IF8Q@201174|Actinobacteria,4FGAK@85021|Intrasporangiaceae	201174|Actinobacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_1868853_1	1244869.H261_01552	2.78e-80	242.0	COG1622@1|root,COG1622@2|Bacteria,1NZNI@1224|Proteobacteria,2UJSY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	cytochrome c oxidase (Subunit II)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1557281_1	1300345.LF41_2649	4.31e-44	162.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9I0@135614|Xanthomonadales	135614|Xanthomonadales	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1557281_2	1267533.KB906742_gene675	6.83e-09	58.9	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria	57723|Acidobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1506364_1	575540.Isop_3456	5.49e-11	60.5	COG0720@1|root,COG0720@2|Bacteria,2J000@203682|Planctomycetes	203682|Planctomycetes	H	COG0720 6-pyruvoyl-tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
k59_1506364_2	426114.THI_1224	6.21e-81	251.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VI9I@28216|Betaproteobacteria,1KJKV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Ammonium Transporter	-	-	-	ko:K03320,ko:K06580	-	-	-	-	ko00000,ko02000,ko04090	1.A.11,1.A.11.4	-	-	Ammonium_transp
k59_559745_1	1218352.B597_005700	2.69e-23	93.6	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria,1YZWH@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO0053,iSDY_1059.SDY_4064	CTP_transf_like
k59_559745_2	913325.N799_10320	6.18e-41	154.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1X5EZ@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC transporter transmembrane region	hlyB	-	-	ko:K11004	ko02010,ko03070,ko05133,map02010,map03070,map05133	M00325,M00575	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.1,3.A.1.109.2	-	-	ABC_membrane,ABC_tran,Peptidase_C39
k59_618399_1	1026882.MAMP_00163	8.08e-35	131.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,45ZRS@72273|Thiotrichales	72273|Thiotrichales	C	TIGRFAM nitrite reductase NAD(P)H , large subunit	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
k59_929277_2	1210045.ALNP01000008_gene4543	9.15e-53	170.0	COG0522@1|root,COG0522@2|Bacteria,2GIRX@201174|Actinobacteria	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_282303_1	314225.ELI_01405	5.26e-45	150.0	2EGQ7@1|root,33AGD@2|Bacteria,1NI1N@1224|Proteobacteria,2UJJ3@28211|Alphaproteobacteria,2K5B7@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_49583_1	640081.Dsui_2039	2.12e-61	201.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,2KV3P@206389|Rhodocyclales	206389|Rhodocyclales	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_49583_2	1150469.RSPPHO_02409	6.8e-11	62.8	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2TQW9@28211|Alphaproteobacteria,2JPGS@204441|Rhodospirillales	204441|Rhodospirillales	E	COG2873 O-acetylhomoserine sulfhydrylase	-	-	2.5.1.47,2.5.1.49	ko:K01738,ko:K01740	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R01287,R03601,R04859	RC00020,RC02814,RC02821,RC02848	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding_2,Cys_Met_Meta_PP
k59_1340658_1	396588.Tgr7_1012	2.52e-241	675.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1WVZB@135613|Chromatiales	135613|Chromatiales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_282316_1	472175.EL18_03223	8.61e-117	362.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,43NDE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_501200_1	1381751.JAJB01000063_gene264	8.41e-56	193.0	COG0151@1|root,COG0152@1|root,COG0151@2|Bacteria,COG0152@2|Bacteria,2GK3H@201174|Actinobacteria,4F9EC@85019|Brevibacteriaceae	201174|Actinobacteria	F	Phosphoribosylglycinamide synthetase, C domain	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01923,ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
k59_1143360_1	1265313.HRUBRA_01495	1.43e-34	128.0	COG1597@1|root,COG1597@2|Bacteria,1RIZ6@1224|Proteobacteria,1S4KN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
k59_1143360_2	1265313.HRUBRA_01494	1.36e-17	81.6	COG1597@1|root,COG1597@2|Bacteria,1RB97@1224|Proteobacteria,1S4B3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	lipid kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Mmp37
k59_325423_1	290399.Arth_3208	9.58e-45	163.0	COG2976@1|root,COG2976@2|Bacteria,2GNIS@201174|Actinobacteria,1WBAK@1268|Micrococcaceae	201174|Actinobacteria	S	Protein of unknown function (DUF4012)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4012
k59_208198_1	335543.Sfum_3990	7.15e-15	73.9	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,Phage_int_SAM_1,Phage_int_SAM_3,Phage_integrase,zf-IS66
k59_1340679_1	575540.Isop_2292	6.46e-91	288.0	COG1505@1|root,COG1505@2|Bacteria,2IXRJ@203682|Planctomycetes	203682|Planctomycetes	E	Prolyl oligopeptidase	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_1206409_1	631362.Thi970DRAFT_03041	1.24e-35	132.0	COG2863@1|root,COG2863@2|Bacteria,1RBXV@1224|Proteobacteria,1SEAS@1236|Gammaproteobacteria,1X1G7@135613|Chromatiales	135613|Chromatiales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_1024726_1	1125863.JAFN01000001_gene1434	1.61e-33	117.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,42TPZ@68525|delta/epsilon subdivisions,2WQ0P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
k59_1024726_2	335543.Sfum_1234	1.07e-70	233.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,2MQ7E@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_988480_1	631362.Thi970DRAFT_03551	1.63e-93	285.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,1WX71@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_1097606_1	381666.H16_B0315	1.79e-26	108.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VNB8@28216|Betaproteobacteria,1KGH9@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1097606_2	1192124.LIG30_2704	5.32e-33	126.0	COG1309@1|root,COG1309@2|Bacteria,1N014@1224|Proteobacteria,2VVAF@28216|Betaproteobacteria,1K44V@119060|Burkholderiaceae	28216|Betaproteobacteria	K	regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1097606_3	1151116.Q7S_14460	6.41e-130	379.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,3FHF2@34037|Rahnella	1236|Gammaproteobacteria	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_1097606_4	1121374.KB891575_gene1524	3.92e-08	52.8	COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,1S94R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_618430_2	1121468.AUBR01000012_gene2601	6.39e-95	278.0	2F0YS@1|root,33U0E@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_107420_1	1292373.H640_05903	7.81e-35	130.0	COG0019@1|root,COG0019@2|Bacteria,2GKAI@201174|Actinobacteria,4DPUN@85009|Propionibacteriales	201174|Actinobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_107420_2	1449355.JQNR01000005_gene4419	3.01e-30	118.0	COG0460@1|root,COG0460@2|Bacteria,2GIX9@201174|Actinobacteria	201174|Actinobacteria	E	homoserine dehydrogenase	hom	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.1.1.3,2.7.2.4	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1294	ACT,Homoserine_dh,NAD_binding_3
k59_1506427_1	670292.JH26_00425	1.25e-172	485.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,1JTSW@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_149711_1	1049564.TevJSym_ac01600	3.2e-61	200.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1J7FM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	GM	NAD(P)H-binding	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
k59_736642_1	1123392.AQWL01000002_gene1698	1.31e-129	398.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,1KS0K@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_1206416_1	1123258.AQXZ01000014_gene4985	3.86e-121	365.0	COG3845@1|root,COG3845@2|Bacteria,2H7KJ@201174|Actinobacteria,4G9EK@85025|Nocardiaceae	201174|Actinobacteria	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
k59_149720_1	1123073.KB899241_gene1972	1.23e-86	278.0	COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,1RR50@1236|Gammaproteobacteria,1XBWN@135614|Xanthomonadales	135614|Xanthomonadales	S	M61 glycyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M61
k59_929377_1	998674.ATTE01000001_gene1687	2.65e-12	65.1	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,460JJ@72273|Thiotrichales	72273|Thiotrichales	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
k59_929377_2	1122604.JONR01000018_gene1117	1.21e-54	180.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1X31Z@135614|Xanthomonadales	135614|Xanthomonadales	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_208230_1	1304865.JAGF01000001_gene2569	1.1e-90	283.0	COG1316@1|root,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria,4F26Q@85016|Cellulomonadaceae	201174|Actinobacteria	K	TIGRFAM cell envelope-related function transcriptional attenuator, LytR CpsA family	yvhJ	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
k59_400959_1	631362.Thi970DRAFT_03932	2.28e-74	243.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,1RNQ2@1236|Gammaproteobacteria,1WW39@135613|Chromatiales	135613|Chromatiales	GM	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
k59_49688_1	765911.Thivi_4353	8.33e-164	475.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1WXIB@135613|Chromatiales	135613|Chromatiales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_208231_1	335543.Sfum_1661	7.23e-169	503.0	COG1026@1|root,COG1026@2|Bacteria,1MVDJ@1224|Proteobacteria,42MRG@68525|delta/epsilon subdivisions,2WJ5Q@28221|Deltaproteobacteria,2MQW0@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Peptidase M16C associated	PREP	-	-	ko:K06972	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M16C_assoc,Peptidase_M16,Peptidase_M16_C
k59_678019_1	1163617.SCD_n02706	9.74e-103	312.0	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,2VI93@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,CbiA,GATase_3
k59_282408_1	472759.Nhal_0349	4.61e-14	70.9	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1WXB6@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_282408_2	765912.Thimo_2751	5.05e-20	84.7	COG3113@1|root,COG3113@2|Bacteria,1NGIE@1224|Proteobacteria,1SGH6@1236|Gammaproteobacteria,1WZDQ@135613|Chromatiales	135613|Chromatiales	S	NTP binding protein (Contains STAS domain)	-	-	-	ko:K07122	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	STAS_2
k59_618461_1	469618.FVAG_01562	2.99e-38	146.0	COG0060@1|root,COG0060@2|Bacteria,3788C@32066|Fusobacteria	32066|Fusobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_1272142_1	572477.Alvin_1359	1.11e-150	449.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales	135613|Chromatiales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_509554_2	338969.Rfer_4168	9.86e-85	262.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VMYW@28216|Betaproteobacteria,4AGYA@80864|Comamonadaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_1623593_1	367299.JOEE01000004_gene1016	2.49e-134	392.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria,4FF6V@85021|Intrasporangiaceae	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_626829_1	1267005.KB911257_gene1038	7.7e-53	182.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2TQSW@28211|Alphaproteobacteria,3N6JD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_1684559_1	948106.AWZT01000098_gene2282	3.09e-107	319.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2VJ2W@28216|Betaproteobacteria,1K2WR@119060|Burkholderiaceae	28216|Betaproteobacteria	S	transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_686273_1	572477.Alvin_1283	1.63e-104	317.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1WVXY@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_1389621_1	1206741.BAFX01000060_gene6627	3.17e-32	127.0	COG0770@1|root,COG0770@2|Bacteria,2GK0Y@201174|Actinobacteria,4FWIU@85025|Nocardiaceae	201174|Actinobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	GO:0008150,GO:0040007	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_509575_1	644107.SL1157_0469	1.69e-107	321.0	COG1638@1|root,COG1638@2|Bacteria,1P574@1224|Proteobacteria,2TUDW@28211|Alphaproteobacteria,4NAYZ@97050|Ruegeria	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1515307_1	556269.ACDQ01000014_gene735	4.65e-65	214.0	COG3033@1|root,COG3033@2|Bacteria,1NG5U@1224|Proteobacteria,2VKQ4@28216|Betaproteobacteria	28216|Betaproteobacteria	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	tnaA	-	4.1.99.1,4.1.99.2	ko:K01667,ko:K01668	ko00350,ko00380,map00350,map00380	-	R00673,R00728	RC00209,RC00355,RC00364	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_1515309_1	1122915.AUGY01000085_gene6144	4.44e-54	188.0	COG1483@1|root,COG1483@2|Bacteria	2|Bacteria	C	ATPase (AAA superfamily	-	-	-	ko:K06922	-	-	-	-	ko00000	-	-	-	DUF499
k59_509586_1	880072.Desac_0836	9.62e-77	255.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MQTI@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
k59_1742453_1	1286093.C266_23266	1.7e-54	177.0	COG4681@1|root,COG4681@2|Bacteria,1RDR9@1224|Proteobacteria,2VR81@28216|Betaproteobacteria,1K28A@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM YaeQ family protein	yaeQ	-	-	-	-	-	-	-	-	-	-	-	YaeQ
k59_1684605_1	382464.ABSI01000012_gene2198	4.16e-64	223.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C
k59_1150777_1	1323663.AROI01000016_gene460	4.7e-100	295.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
k59_1449617_1	768671.ThimaDRAFT_0223	5.54e-13	67.8	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,1RN1W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
k59_796362_1	1500893.JQNB01000001_gene411	1.56e-59	206.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1X4MI@135614|Xanthomonadales	135614|Xanthomonadales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_796362_2	1235279.C772_02581	5.57e-11	63.9	COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,4H9SZ@91061|Bacilli,26EHQ@186818|Planococcaceae	91061|Bacilli	U	symporter	agcS	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_452126_2	666685.R2APBS1_1476	2.02e-18	86.7	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1X4G8@135614|Xanthomonadales	135614|Xanthomonadales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_569301_1	686340.Metal_3918	8.13e-08	57.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,1XED6@135618|Methylococcales	135618|Methylococcales	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_569301_2	765913.ThidrDRAFT_2991	1.36e-17	75.1	2AJN3@1|root,31A9F@2|Bacteria,1QMVM@1224|Proteobacteria,1TK62@1236|Gammaproteobacteria,1WZRM@135613|Chromatiales	135613|Chromatiales	S	Cysteine-rich CPXCG	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_CPXG
k59_1450999_1	177437.HRM2_27230	1.48e-84	268.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2WJCI@28221|Deltaproteobacteria,2MHS8@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_1743732_1	926569.ANT_01060	2.89e-09	57.0	COG5012@1|root,COG5012@2|Bacteria,2G66F@200795|Chloroflexi	200795|Chloroflexi	D	cobalamin binding	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding
k59_1743747_1	713587.THITH_06845	2.12e-79	245.0	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,1RQBE@1236|Gammaproteobacteria,1WX20@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
k59_1743747_2	713587.THITH_07415	2.25e-62	207.0	COG0223@1|root,COG1024@1|root,COG0223@2|Bacteria,COG1024@2|Bacteria,1MWYJ@1224|Proteobacteria,1RZSE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IJ	Belongs to the enoyl-CoA hydratase isomerase family	hoxX	-	-	ko:K19640	-	-	-	-	ko00000,ko02022	-	-	-	ECH_1,Formyl_trans_C,Formyl_trans_N
k59_452144_1	1380354.JIAN01000006_gene1054	3.79e-77	246.0	COG1271@1|root,COG1271@2|Bacteria,2GJE4@201174|Actinobacteria,4F0IB@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM cytochrome bd ubiquinol oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_1516723_1	1454010.JEOE01000003_gene214	2.13e-57	189.0	COG0365@1|root,COG0365@2|Bacteria,2I2IW@201174|Actinobacteria,4F2DQ@85016|Cellulomonadaceae	201174|Actinobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
k59_569328_2	1304865.JAGF01000001_gene2217	6.33e-12	63.9	COG1309@1|root,COG1309@2|Bacteria,2HG87@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1390835_1	1396141.BATP01000060_gene4560	3.41e-19	94.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,46UAE@74201|Verrucomicrobia,2IV44@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_12,WD40
k59_569330_1	452637.Oter_3541	1.62e-92	292.0	COG0843@1|root,COG1845@1|root,COG0843@2|Bacteria,COG1845@2|Bacteria,46S4Q@74201|Verrucomicrobia,3K7EE@414999|Opitutae	74201|Verrucomicrobia	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274,ko:K15408	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_1566616_1	1385521.N803_03665	2.43e-131	383.0	COG0494@1|root,COG2062@1|root,COG0494@2|Bacteria,COG2062@2|Bacteria,2GNRV@201174|Actinobacteria,4FF7Y@85021|Intrasporangiaceae	201174|Actinobacteria	L	phosphohistidine phosphatase	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1,NUDIX
k59_1566616_2	953739.SVEN_3904	5.44e-35	134.0	COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria	201174|Actinobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_1516741_1	1123371.ATXH01000045_gene1871	6.48e-116	344.0	28I4Y@1|root,2Z88D@2|Bacteria,2GI90@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_687451_1	1049564.TevJSym_ak00640	1.31e-24	107.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1J4R4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_1215739_1	1313172.YM304_28950	6.57e-46	154.0	COG0560@1|root,COG0560@2|Bacteria,2H4ZQ@201174|Actinobacteria	201174|Actinobacteria	E	haloacid dehalogenase-like hydrolase	-	-	2.7.1.39,3.1.3.3	ko:K02203	ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230	M00018	R00582,R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD
k59_1108181_1	977880.RALTA_A2600	6.11e-101	305.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2VI2T@28216|Betaproteobacteria,1K1FI@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
k59_217449_1	1379270.AUXF01000001_gene2209	3.07e-70	224.0	COG0332@1|root,COG0332@2|Bacteria,1ZU9P@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_863002_1	367299.JOEE01000007_gene134	2.86e-69	216.0	COG1214@1|root,COG1214@2|Bacteria,2GMTM@201174|Actinobacteria,4FH78@85021|Intrasporangiaceae	201174|Actinobacteria	O	peptidase M22	yeaZ	GO:0002949,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
k59_335443_1	1089455.MOPEL_094_00020	2.56e-24	104.0	COG4284@1|root,COG4284@2|Bacteria,2I2G3@201174|Actinobacteria,4F6B8@85018|Dermatophilaceae	201174|Actinobacteria	G	UTP--glucose-1-phosphate uridylyltransferase	ugp	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPGP
k59_335443_2	1304885.AUEY01000022_gene3385	8.7e-16	76.3	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WJ7X@28221|Deltaproteobacteria,2MIWF@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iAF987.Gmet_2853	Aminotran_4
k59_1743783_1	686578.AFFX01000001_gene1414	3.97e-56	184.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,1S22U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1624839_1	1235457.C404_01335	7.75e-49	160.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VR39@28216|Betaproteobacteria,1K5JG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
k59_1451053_1	471853.Bcav_1977	2.5e-115	339.0	COG0115@1|root,COG0115@2|Bacteria,2GN5Z@201174|Actinobacteria	201174|Actinobacteria	EH	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_1451053_2	1095767.CAHD01000200_gene2363	1.72e-145	424.0	COG0147@1|root,COG0147@2|Bacteria,2GN7D@201174|Actinobacteria,4F1NN@85016|Cellulomonadaceae	201174|Actinobacteria	EH	chorismate binding enzyme	pabB	-	2.6.1.85,4.1.3.38	ko:K01665,ko:K03342	ko00790,map00790	-	R01716,R05553	RC00010,RC01418,RC01843,RC02148	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4,Chorismate_bind
k59_1686022_2	710687.KI912270_gene6000	3.43e-35	128.0	COG3588@1|root,COG3588@2|Bacteria,2GN1A@201174|Actinobacteria,233KA@1762|Mycobacteriaceae	201174|Actinobacteria	G	Aldolase	fda	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
k59_1151887_2	1121286.AUMT01000010_gene3939	0.000509	48.1	COG1216@1|root,COG1216@2|Bacteria,4NRF1@976|Bacteroidetes,1I2Y2@117743|Flavobacteriia,3ZNYW@59732|Chryseobacterium	976|Bacteroidetes	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1282552_2	261292.Nit79A3_2700	1.91e-36	125.0	COG1531@1|root,COG1531@2|Bacteria,1N7PM@1224|Proteobacteria,2W6WU@28216|Betaproteobacteria,374JG@32003|Nitrosomonadales	28216|Betaproteobacteria	AJ	Protein of unknown function (DUF504)	-	-	-	-	-	-	-	-	-	-	-	-	DUF504
k59_1282552_3	671143.DAMO_0419	4.57e-11	63.2	COG2234@1|root,COG2234@2|Bacteria,2NQ2F@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M28	yfbL	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
k59_569357_1	313628.LNTAR_11846	1.09e-26	108.0	COG2327@1|root,COG2327@2|Bacteria	2|Bacteria	S	slime layer polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
k59_569357_2	1033810.HLPCO_001414	5.95e-18	82.0	COG0424@1|root,COG0424@2|Bacteria,2NPJA@2323|unclassified Bacteria	2|Bacteria	D	Maf-like protein	maf	GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0022402,GO:0022607,GO:0030428,GO:0032506,GO:0044085,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0090529,GO:1902410,GO:1903047	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_1035098_1	472759.Nhal_0353	7.94e-55	179.0	COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,1RNBU@1236|Gammaproteobacteria,1WY4I@135613|Chromatiales	135613|Chromatiales	S	NGG1p interacting factor 3	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
k59_217475_2	426114.THI_0149	3.45e-77	239.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2VHWI@28216|Betaproteobacteria,1KJRF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	CbbQ/NirQ/NorQ C-terminal	cbbQ	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
k59_687483_1	1038862.KB893884_gene688	1.09e-61	212.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_335474_1	933262.AXAM01000050_gene3478	4.13e-81	248.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,42P58@68525|delta/epsilon subdivisions,2WKYK@28221|Deltaproteobacteria,2MIV5@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0547	Asp_Glu_race
k59_1798995_1	1121020.JIAG01000016_gene644	1.26e-09	64.3	COG1361@1|root,COG3291@1|root,COG4719@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,COG4719@2|Bacteria,2I8F1@201174|Actinobacteria,1WC6E@1268|Micrococcaceae	201174|Actinobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
k59_1798995_2	105559.Nwat_0622	1.14e-61	196.0	COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,1RSM2@1236|Gammaproteobacteria,1WX5K@135613|Chromatiales	135613|Chromatiales	L	Belongs to the Nudix hydrolase family	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_687485_1	292415.Tbd_1263	8.01e-84	264.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,2VJT0@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hoxH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
k59_1151910_2	1051985.l11_18860	2.45e-26	110.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,2KPC3@206351|Neisseriales	206351|Neisseriales	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
k59_797371_1	55529.EKX37986	1.17e-19	87.8	2CY47@1|root,2S1X0@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_797371_2	6669.EFX61642	1.36e-11	63.9	2E6PU@1|root,2SDCQ@2759|Eukaryota,3ABW1@33154|Opisthokonta,3BVKN@33208|Metazoa,3DJX5@33213|Bilateria,4239J@6656|Arthropoda	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_159283_1	497964.CfE428DRAFT_4541	1.77e-13	70.1	COG0232@1|root,COG0232@2|Bacteria	2|Bacteria	F	Belongs to the dGTPase family. Type 2 subfamily	dgt	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	iJN678.dgt	HD,HD_assoc
k59_159283_2	1166948.JPZL01000004_gene237	7.97e-37	138.0	COG0128@1|root,COG0287@1|root,COG0128@2|Bacteria,COG0287@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1XIJ8@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	1.3.1.12,2.5.1.19	ko:K00210,ko:K00800	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00022,M00025	R01728,R03460	RC00125,RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase,PDH
k59_1282596_1	1304865.JAGF01000001_gene1464	1.94e-30	119.0	COG4143@1|root,COG4143@2|Bacteria,2GMWD@201174|Actinobacteria,4F20D@85016|Cellulomonadaceae	201174|Actinobacteria	P	TIGRFAM ABC transporter, periplasmic binding protein, thiB subfamily	tbpA	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6
k59_1799008_1	1249627.D779_2579	1.87e-70	221.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,1RR9N@1236|Gammaproteobacteria,1WX27@135613|Chromatiales	135613|Chromatiales	S	permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
k59_1799008_2	1049564.TevJSym_ae00910	2.51e-118	350.0	COG0477@1|root,COG2814@2|Bacteria,1MV8D@1224|Proteobacteria,1RNF0@1236|Gammaproteobacteria,1J4TF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1516832_1	1267005.KB911256_gene1961	3.39e-28	112.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2TRFV@28211|Alphaproteobacteria,3N6IF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_1516832_2	1267005.KB911256_gene1962	5.97e-75	228.0	COG5480@1|root,COG5480@2|Bacteria,1RISQ@1224|Proteobacteria,2U9NW@28211|Alphaproteobacteria,3N71I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1036)	MA20_03870	-	-	-	-	-	-	-	-	-	-	-	DUF1036
k59_1516837_1	396588.Tgr7_1682	1.94e-62	204.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,1RPNX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1282609_1	768671.ThimaDRAFT_0870	3.32e-70	218.0	COG3009@1|root,COG3009@2|Bacteria,1N9IG@1224|Proteobacteria,1SCIM@1236|Gammaproteobacteria,1X1Z1@135613|Chromatiales	135613|Chromatiales	S	ABC-type transport auxiliary lipoprotein component	-	-	-	-	-	-	-	-	-	-	-	-	ABC_trans_aux
k59_159294_1	1177154.Y5S_00153	9.39e-10	62.4	COG1075@1|root,COG1075@2|Bacteria,1N2W0@1224|Proteobacteria,1S2JW@1236|Gammaproteobacteria,1XP3H@135619|Oceanospirillales	135619|Oceanospirillales	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1516845_1	1108849.XP_002566331.1	6.2e-16	82.0	COG1104@1|root,KOG1549@2759|Eukaryota,39V6W@33154|Opisthokonta,3NWXZ@4751|Fungi,3QMGP@4890|Ascomycota,20FCR@147545|Eurotiomycetes,3S5FB@5042|Eurotiales	4751|Fungi	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_1799020_1	266940.Krad_4162	1.37e-96	288.0	COG0274@1|root,COG0274@2|Bacteria,2GJIR@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
k59_1052568_1	102125.Xen7305DRAFT_00043980	2.04e-25	102.0	COG2928@1|root,COG2928@2|Bacteria	2|Bacteria	S	Conserved Protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
k59_1810938_1	1121405.dsmv_2089	2.94e-58	193.0	COG0702@1|root,COG0702@2|Bacteria,1QZ67@1224|Proteobacteria,42TVU@68525|delta/epsilon subdivisions,2X7SH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
k59_640351_1	981369.JQMJ01000003_gene7949	6.68e-34	125.0	COG1082@1|root,COG1082@2|Bacteria,2GJ6E@201174|Actinobacteria,2NFDF@228398|Streptacidiphilus	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
k59_640351_2	1410634.JHVD01000002_gene247	6.21e-33	119.0	2DC18@1|root,2ZCCT@2|Bacteria,2IBBW@201174|Actinobacteria,4DUJG@85009|Propionibacteriales	201174|Actinobacteria	S	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
k59_1052575_1	1499967.BAYZ01000048_gene2702	3.49e-70	219.0	COG3752@1|root,COG3752@2|Bacteria,2NR3R@2323|unclassified Bacteria	2|Bacteria	S	3-oxo-5-alpha-steroid 4-dehydrogenase	yfhH	-	1.3.1.22	ko:K12343	ko00140,map00140	-	R02208,R02497,R08954,R10242	RC00145	ko00000,ko00001,ko01000	-	-	-	DUF1295
k59_1700702_1	1121405.dsmv_0618	3.45e-97	301.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,42PSJ@68525|delta/epsilon subdivisions,2WJDD@28221|Deltaproteobacteria,2MHWQ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	reductase, alpha subunit	aprA	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
k59_640365_1	1454004.AW11_02845	4.71e-118	352.0	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,2VPFR@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_464595_1	572477.Alvin_0037	1.62e-38	135.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1WX04@135613|Chromatiales	135613|Chromatiales	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_464595_2	631362.Thi970DRAFT_03474	7.06e-24	99.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1WWNZ@135613|Chromatiales	135613|Chromatiales	K	Belongs to the ParB family	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_348761_2	388413.ALPR1_04898	1.04e-48	169.0	COG4799@1|root,COG4799@2|Bacteria,4NEMJ@976|Bacteroidetes,47K3E@768503|Cytophagia	976|Bacteroidetes	I	Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta)	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_1052617_1	367299.JOEE01000005_gene3471	9.43e-32	123.0	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,4FEJ7@85021|Intrasporangiaceae	201174|Actinobacteria	EF	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_1052617_2	367299.JOEE01000005_gene3472	1.49e-54	178.0	COG0543@1|root,COG0543@2|Bacteria,2HQ24@201174|Actinobacteria,4FFS3@85021|Intrasporangiaceae	201174|Actinobacteria	C	Dihydroorotate oxidase	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
k59_173652_1	713586.KB900536_gene2920	4.76e-95	284.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,1RMWC@1236|Gammaproteobacteria,1WWK4@135613|Chromatiales	135613|Chromatiales	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
k59_173652_2	1249627.D779_3464	2.08e-59	185.0	COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,1S5XX@1236|Gammaproteobacteria,1WYID@135613|Chromatiales	135613|Chromatiales	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
k59_348770_1	1249627.D779_3714	1.03e-79	267.0	COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,1RR5W@1236|Gammaproteobacteria,1WX8Z@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	2.7.13.3	ko:K02482,ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,MASE1,PAS_4,PAS_9
k59_581473_1	443144.GM21_1112	4.67e-87	283.0	COG0204@1|root,COG1647@1|root,COG0204@2|Bacteria,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,42NBK@68525|delta/epsilon subdivisions,2WIUP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Serine aminopeptidase, S33	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Acyltransferase,Hydrolase_4
k59_231494_1	765952.PUV_14580	8.02e-102	315.0	COG0365@1|root,COG0365@2|Bacteria,2JFRM@204428|Chlamydiae	204428|Chlamydiae	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_879033_1	765914.ThisiDRAFT_1947	1.75e-75	253.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1WX8F@135613|Chromatiales	135613|Chromatiales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_1230496_1	1297617.JPJD01000012_gene849	2.13e-10	60.8	COG1481@1|root,COG1481@2|Bacteria,1TP2X@1239|Firmicutes,2484M@186801|Clostridia,268FN@186813|unclassified Clostridiales	186801|Clostridia	K	May be required for sporulation	whiA	-	-	ko:K09762	-	-	-	-	ko00000	-	-	-	HTH_WhiA,LAGLIDADG_WhiA,WhiA_N
k59_1230496_2	997296.PB1_09602	6.91e-08	58.2	COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,4H9NS@91061|Bacilli,1ZCF9@1386|Bacillus	91061|Bacilli	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gapA	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_1464447_1	1278309.KB907103_gene1195	2.08e-53	185.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,1RNH4@1236|Gammaproteobacteria,1XHDV@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
k59_760709_1	367299.JOEE01000004_gene1155	9.95e-136	417.0	COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,4FFAB@85021|Intrasporangiaceae	201174|Actinobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_1756172_1	644966.Tmar_0100	2.01e-78	262.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,3WCCX@538999|Clostridiales incertae sedis	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_231516_1	1286106.MPL1_12000	1.44e-70	222.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,45ZR2@72273|Thiotrichales	72273|Thiotrichales	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_581496_1	1961.JOAK01000016_gene5233	1.72e-35	136.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria	201174|Actinobacteria	OT	Pyridine nucleotide-disulphide oxidoreductase	trxB2	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,cNMP_binding
k59_1052683_1	666686.B1NLA3E_05580	1.41e-71	225.0	COG2084@1|root,COG2084@2|Bacteria,1TR4F@1239|Firmicutes,4H9MA@91061|Bacilli,1ZBSG@1386|Bacillus	91061|Bacilli	I	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases	glxR	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_1052691_1	1123256.KB907925_gene1399	1.69e-59	196.0	COG1226@1|root,COG1226@2|Bacteria,1MXQP@1224|Proteobacteria,1SWIH@1236|Gammaproteobacteria,1XAQW@135614|Xanthomonadales	135614|Xanthomonadales	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_N
k59_808245_1	869213.JCM21142_52279	9.93e-56	188.0	COG1449@1|root,COG1449@2|Bacteria,4NFXW@976|Bacteroidetes,47P2J@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 57 family	amyA	-	3.2.1.1	ko:K07405	ko00500,ko01100,map00500,map01100	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH57	-	Glyco_hydro_57
k59_1230533_1	1085623.GNIT_3417	5.41e-61	199.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,1T1RB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	NADH flavin oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_581509_1	335543.Sfum_3227	1.21e-38	138.0	COG4244@1|root,COG4892@1|root,COG4244@2|Bacteria,COG4892@2|Bacteria,1N3DP@1224|Proteobacteria,42U1X@68525|delta/epsilon subdivisions,2WQFI@28221|Deltaproteobacteria,2MRX2@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Cytochrome b5-like Heme/Steroid binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CopD,Cyt-b5
k59_464689_1	1123518.ARWI01000001_gene60	2.52e-55	184.0	COG2267@1|root,COG2267@2|Bacteria,1QUQ9@1224|Proteobacteria,1T20W@1236|Gammaproteobacteria,463VD@72273|Thiotrichales	72273|Thiotrichales	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
k59_1581938_1	314287.GB2207_01492	1.09e-17	82.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,1RNH3@1236|Gammaproteobacteria,1J5AJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	COG0331 (acyl-carrier-protein) S-malonyltransferase	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iEcE24377_1341.EcE24377A_1213,iJN746.PP_1913,iPC815.YPO1598	Acyl_transf_1
k59_1581938_2	1212548.B381_14853	3.77e-28	106.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,1YZXY@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	U	general secretion pathway protein G	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
k59_1464478_1	204669.Acid345_4083	1.55e-92	293.0	COG1195@1|root,COG3593@1|root,COG1195@2|Bacteria,COG3593@2|Bacteria,3Y7ZQ@57723|Acidobacteria	57723|Acidobacteria	L	Protein of unknown function (DUF2813)	-	-	-	ko:K07459	-	-	-	-	ko00000	-	-	-	DUF2813
k59_1052718_1	1121017.AUFG01000035_gene694	2.62e-51	167.0	COG4113@1|root,COG4113@2|Bacteria,2GR4U@201174|Actinobacteria,4FHJX@85021|Intrasporangiaceae	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
k59_1052718_2	1096756.ATKN01000013_gene646	7.96e-27	107.0	COG0294@1|root,COG0294@2|Bacteria,2GJNI@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
k59_1052719_1	367299.JOEE01000005_gene3615	3.23e-127	369.0	COG2896@1|root,COG2896@2|Bacteria,2GN0V@201174|Actinobacteria,4FFGU@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
k59_1052719_2	367299.JOEE01000005_gene3614	5.18e-62	198.0	COG3346@1|root,COG3346@2|Bacteria,2GR90@201174|Actinobacteria,4FGD6@85021|Intrasporangiaceae	201174|Actinobacteria	S	SURF1-like protein	-	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	SURF1
k59_1164798_2	641491.DND132_1416	3.09e-35	133.0	COG1571@1|root,COG1571@2|Bacteria,1REWB@1224|Proteobacteria,42QPN@68525|delta/epsilon subdivisions,2WN6E@28221|Deltaproteobacteria,2MG9H@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	tRNA wobble cytosine modification	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_879094_1	105559.Nwat_2753	1.31e-61	202.0	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria,1WX4U@135613|Chromatiales	135613|Chromatiales	T	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD_5
k59_464706_1	1158756.AQXQ01000012_gene1500	1.3e-67	209.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,1RN32@1236|Gammaproteobacteria,1WWN9@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
k59_464706_2	349124.Hhal_1758	3.93e-25	102.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1WXDH@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_348862_2	713586.KB900536_gene167	1.63e-155	442.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1WX3I@135613|Chromatiales	135613|Chromatiales	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1405327_1	1280954.HPO_02292	0.000335	48.5	COG1629@1|root,COG1629@2|Bacteria,1R479@1224|Proteobacteria,2TV3V@28211|Alphaproteobacteria,43Z4Z@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,STN,TonB_dep_Rec
k59_1230575_1	1085623.GNIT_0046	1.98e-62	210.0	COG2234@1|root,COG2234@2|Bacteria,1MUZ7@1224|Proteobacteria,1RS0Q@1236|Gammaproteobacteria,4653N@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_1052758_1	349521.HCH_01466	1.27e-114	362.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XH3T@135619|Oceanospirillales	135619|Oceanospirillales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1756235_1	1157708.KB907455_gene3236	1.11e-149	433.0	COG0584@1|root,COG0584@2|Bacteria,1MVWZ@1224|Proteobacteria,2VHU2@28216|Betaproteobacteria,4AASP@80864|Comamonadaceae	28216|Betaproteobacteria	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_1756246_1	1123013.AUIC01000002_gene1190	6.41e-25	108.0	COG0791@1|root,COG0791@2|Bacteria,2GIWB@201174|Actinobacteria,4FKYP@85023|Microbacteriaceae	201174|Actinobacteria	M	NlpC/P60 family	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,PG_binding_1
k59_640494_1	1047013.AQSP01000128_gene452	1.11e-100	306.0	COG0403@1|root,COG0403@2|Bacteria,2NNP1@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
k59_879147_1	1049564.TevJSym_an00750	1.98e-84	255.0	COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,1J5U7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis	rnt	GO:0000287,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360	-	ko:K03683	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_T
k59_173781_1	1307761.L21SP2_2277	3.89e-76	241.0	COG3344@1|root,COG3344@2|Bacteria	2|Bacteria	L	reverse transcriptase	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,HNH,RVT_1
k59_1405341_1	1122194.AUHU01000005_gene946	3.65e-124	382.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,464S9@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_2160,iPC815.YPO2428	B3_4,B5,FDX-ACB,tRNA_bind
k59_1230601_1	1396418.BATQ01000042_gene6402	4.83e-06	54.3	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	ko:K15125	ko05133,map05133	-	-	-	ko00000,ko00001,ko00536	-	-	-	Beta_helix,CUB,Calx-beta,DUF3739,Haemagg_act,SdrD_B
k59_879150_1	1500894.JQNN01000001_gene3271	1.57e-73	242.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria,4728K@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Ferrous iron transport protein B C terminus	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_879150_2	556269.ACDQ01000017_gene935	1.99e-13	67.8	COG1918@1|root,COG1918@2|Bacteria	2|Bacteria	P	iron ion homeostasis	feoA	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
k59_1639280_1	335543.Sfum_3202	5.78e-104	313.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,42M84@68525|delta/epsilon subdivisions,2WJ5V@28221|Deltaproteobacteria,2MQX5@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
k59_760806_1	768671.ThimaDRAFT_3828	0.0	968.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1WX9H@135613|Chromatiales	135613|Chromatiales	C	pyruvate flavodoxin ferredoxin oxidoreductase	-	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_233333_1	1304872.JAGC01000009_gene111	8.53e-28	116.0	COG0642@1|root,COG0745@1|root,COG0642@2|Bacteria,COG0745@2|Bacteria,1NWAF@1224|Proteobacteria,43BKC@68525|delta/epsilon subdivisions,2X6YB@28221|Deltaproteobacteria,2MH8E@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_8,Response_reg
k59_1232304_1	1380391.JIAS01000012_gene4081	4.71e-08	55.1	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,2TRRU@28211|Alphaproteobacteria,2JQ4F@204441|Rhodospirillales	204441|Rhodospirillales	GK	ROK family	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	ROK
k59_1232304_2	1211115.ALIQ01000204_gene4786	1.09e-22	90.9	2DNWQ@1|root,32ZJY@2|Bacteria,1Q49Z@1224|Proteobacteria,2VASF@28211|Alphaproteobacteria,3NBMC@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3572)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3572
k59_1055147_1	42256.RradSPS_2485	4.56e-146	428.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4CRNM@84995|Rubrobacteria	84995|Rubrobacteria	EQ	PFAM Hydantoinase B oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_350639_1	926564.KI911765_gene4581	3.26e-35	140.0	COG1403@1|root,COG1403@2|Bacteria,2HAHI@201174|Actinobacteria,4F3G4@85017|Promicromonosporaceae	201174|Actinobacteria	V	Domain of unknown function (DUF222)	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_1167042_1	335543.Sfum_1265	1.85e-56	196.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,42NF0@68525|delta/epsilon subdivisions,2WIJK@28221|Deltaproteobacteria,2MQFN@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
k59_642045_1	754436.JCM19237_173	8.14e-13	66.2	arCOG03638@1|root,2Z8W3@2|Bacteria,1N2PH@1224|Proteobacteria,1RMI8@1236|Gammaproteobacteria,1XUA3@135623|Vibrionales	135623|Vibrionales	S	Protein of unknown function (DUF1538)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1538
k59_642045_2	1283300.ATXB01000001_gene2296	8.8e-48	155.0	COG0347@1|root,COG0347@2|Bacteria,1RI28@1224|Proteobacteria,1S62Z@1236|Gammaproteobacteria,1XFB1@135618|Methylococcales	135618|Methylococcales	K	Nitrogen regulatory protein P-II	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_642045_3	1049564.TevJSym_ai00560	7.42e-25	96.3	COG2905@1|root,COG2905@2|Bacteria,1MZGY@1224|Proteobacteria,1S86K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_702376_1	1249627.D779_0584	1.83e-82	271.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales	135613|Chromatiales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_762618_1	2340.JV46_28370	1.93e-50	167.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1J5QR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Belongs to the peptidase S26 family	lepB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_762618_2	105559.Nwat_0675	1.18e-10	61.2	COG4969@1|root,COG4969@2|Bacteria,1N71K@1224|Proteobacteria,1SCYD@1236|Gammaproteobacteria,1WYXD@135613|Chromatiales	135613|Chromatiales	NU	Domain of unknown function (DUF4845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4845
k59_233349_1	225937.HP15_953	2.18e-77	247.0	COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,1RRA5@1236|Gammaproteobacteria,46AE0@72275|Alteromonadaceae	1236|Gammaproteobacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
k59_175564_1	323261.Noc_1657	2.79e-71	223.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,1RP6E@1236|Gammaproteobacteria,1WXA1@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM hydrolase, TatD family	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
k59_522948_1	713586.KB900536_gene2586	5.23e-77	256.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales	135613|Chromatiales	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_466860_2	646529.Desaci_2662	8.16e-07	50.8	COG0477@1|root,COG2814@2|Bacteria,1TPPY@1239|Firmicutes,247T9@186801|Clostridia,25ZYZ@186807|Peptococcaceae	186801|Clostridia	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_809643_1	489825.LYNGBM3L_02000	8.02e-98	308.0	COG1834@1|root,COG1915@1|root,COG1834@2|Bacteria,COG1915@2|Bacteria,1G2AU@1117|Cyanobacteria,1H7S0@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM LOR SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf,Saccharop_dh_N
k59_1055213_1	237368.SCABRO_02098	1.1e-29	119.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2IX0T@203682|Planctomycetes	203682|Planctomycetes	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PEP-utilizers,PPDK_N
k59_1583359_1	765911.Thivi_1773	3.76e-06	46.6	2BU1D@1|root,32PA2@2|Bacteria,1N4TV@1224|Proteobacteria,1SBJ8@1236|Gammaproteobacteria,1WZ1H@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1583359_2	1120999.JONM01000010_gene4043	4.75e-11	63.2	COG1720@1|root,COG1720@2|Bacteria,1MUF0@1224|Proteobacteria,2VMVI@28216|Betaproteobacteria,2KQTV@206351|Neisseriales	206351|Neisseriales	S	Methyltransferase, YaeB family	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
k59_350688_1	1249997.JHZW01000003_gene3217	1.75e-77	241.0	COG0451@1|root,COG0451@2|Bacteria,4NGJ6@976|Bacteroidetes,1HZK8@117743|Flavobacteriia,2PGAN@252356|Maribacter	976|Bacteroidetes	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_1232358_1	1123251.ATWM01000004_gene1863	7.85e-82	250.0	COG1011@1|root,COG1011@2|Bacteria,2HHHH@201174|Actinobacteria,4FIFT@85021|Intrasporangiaceae	201174|Actinobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
k59_240698_2	1230476.C207_03370	1.87e-22	93.2	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2U9GC@28211|Alphaproteobacteria,3JQWH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
k59_767361_2	273068.TTE0480	6.89e-11	63.9	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,42F9U@68295|Thermoanaerobacterales	186801|Clostridia	K	Periplasmic binding protein LacI transcriptional regulator	ccpA	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
k59_1472762_1	666685.R2APBS1_0310	1.88e-43	159.0	COG1668@1|root,COG1668@2|Bacteria,1R3RG@1224|Proteobacteria,1RQT1@1236|Gammaproteobacteria,1X3GM@135614|Xanthomonadales	135614|Xanthomonadales	CP	permease	natB	-	-	ko:K09696	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.115	-	-	ABC2_membrane_2,ABC2_membrane_3
k59_1472769_1	485915.Dret_2112	2.1e-19	93.2	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,42MBW@68525|delta/epsilon subdivisions,2WK2Z@28221|Deltaproteobacteria,2M972@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	TIGRFAM ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Rrf2,Virul_fac_BrkB
k59_1589492_2	1304885.AUEY01000154_gene135	1.32e-33	117.0	COG2442@1|root,COG2442@2|Bacteria,1N96I@1224|Proteobacteria,42VWX@68525|delta/epsilon subdivisions,2X6NY@28221|Deltaproteobacteria,2MP3C@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
k59_240708_1	1123234.AUKI01000020_gene897	1.04e-69	232.0	COG2195@1|root,COG2195@2|Bacteria,4NG8I@976|Bacteroidetes,1HWUA@117743|Flavobacteriia	976|Bacteroidetes	E	aminoacyl-histidine dipeptidase	pepD	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_1648859_1	870187.Thini_1187	4.06e-163	479.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,4608U@72273|Thiotrichales	72273|Thiotrichales	P	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
k59_6829_1	1249997.JHZW01000002_gene283	3.69e-113	342.0	COG2382@1|root,COG2382@2|Bacteria,4NGBK@976|Bacteroidetes,1I15X@117743|Flavobacteriia,2PGC0@252356|Maribacter	976|Bacteroidetes	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_1707286_1	1485544.JQKP01000015_gene2087	5.24e-30	122.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2VHKJ@28216|Betaproteobacteria,44VU4@713636|Nitrosomonadales	28216|Betaproteobacteria	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1765710_1	293227.XP_008713228.1	7.84e-43	159.0	COG1053@1|root,KOG2404@2759|Eukaryota,39DTI@33154|Opisthokonta,3NVIV@4751|Fungi,3QRIN@4890|Ascomycota,20CCV@147545|Eurotiomycetes,3MVTV@451870|Chaetothyriomycetidae	4751|Fungi	C	FAD binding domain	-	GO:0008150,GO:0008152,GO:0019748	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
k59_474531_1	913865.DOT_6141	5.13e-20	94.7	COG2096@1|root,COG3193@1|root,COG2096@2|Bacteria,COG3193@2|Bacteria,1V3PI@1239|Firmicutes,24C7G@186801|Clostridia,263CK@186807|Peptococcaceae	186801|Clostridia	S	Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans,Haem_degrading
k59_6836_1	471853.Bcav_1989	8.77e-114	330.0	COG0217@1|root,COG0217@2|Bacteria,2GJ4G@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
k59_1472791_2	1265505.ATUG01000001_gene4348	1.32e-37	130.0	COG0023@1|root,COG0023@2|Bacteria,1MZ8T@1224|Proteobacteria,42TW6@68525|delta/epsilon subdivisions,2WQNT@28221|Deltaproteobacteria,2MKRE@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Translation initiation factor SUI1	yciH	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
k59_1472791_3	237368.SCABRO_00505	4.91e-06	47.8	COG2996@1|root,COG2996@2|Bacteria,2J1Y7@203682|Planctomycetes	203682|Planctomycetes	S	S1 domain	-	-	-	ko:K00243	-	-	-	-	ko00000	-	-	-	S1_2
k59_474535_1	1415780.JPOG01000001_gene2395	1.06e-69	224.0	COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,1RPGZ@1236|Gammaproteobacteria,1X3XE@135614|Xanthomonadales	135614|Xanthomonadales	E	Glycine cleavage system P-protein	-	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
k59_1119663_1	1184607.AUCHE_05_06090	3.03e-95	299.0	COG1882@1|root,COG1882@2|Bacteria,2GTTT@201174|Actinobacteria,4F7MD@85018|Dermatophilaceae	201174|Actinobacteria	C	Glycine radical	pflB	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
k59_299261_1	1304865.JAGF01000001_gene3604	6.6e-86	282.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4F0IU@85016|Cellulomonadaceae	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1707898_1	1178482.BJB45_19110	1.07e-90	280.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XI3Y@135619|Oceanospirillales	135619|Oceanospirillales	T	Response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes	glnG	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1473700_2	47839.CCAU010000021_gene3123	6.81e-29	117.0	COG0343@1|root,COG0343@2|Bacteria,2I9KU@201174|Actinobacteria,238ZT@1762|Mycobacteriaceae	201174|Actinobacteria	J	queuine tRNA-ribosyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_122969_1	391037.Sare_4708	1.18e-12	67.8	COG1194@1|root,COG1194@2|Bacteria,2GJD9@201174|Actinobacteria,4D9MC@85008|Micromonosporales	201174|Actinobacteria	L	FES	mutY	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_827194_1	1300345.LF41_1818	1.36e-51	184.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1X4W6@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the peptidase S41A family	prc	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF3340,PDZ,Peptidase_S41
k59_181697_1	1121405.dsmv_2161	2.75e-104	318.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2MHPV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_534014_1	1045009.AFXQ01000011_gene482	6.33e-52	174.0	COG2984@1|root,COG2984@2|Bacteria,2GKNV@201174|Actinobacteria,1W7KU@1268|Micrococcaceae	201174|Actinobacteria	S	sugar ABC transporter, substrate-binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
k59_1238799_2	395493.BegalDRAFT_3110	2.99e-43	149.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,460UW@72273|Thiotrichales	72273|Thiotrichales	IQ	short-chain dehydrogenase reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_888897_1	13035.Dacsa_2625	2.26e-14	80.5	COG3210@1|root,COG3595@1|root,COG4070@1|root,COG3210@2|Bacteria,COG3595@2|Bacteria,COG4070@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	ko:K15125,ko:K20276	ko02024,ko05133,map02024,map05133	-	-	-	ko00000,ko00001,ko00536	-	-	-	CHU_C,DUF4097,FG-GAP_2,Glug,Haemagg_act,Laminin_G_3,PA14,SprB
k59_1828136_1	497321.C664_02695	2.17e-60	189.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2VR52@28216|Betaproteobacteria,2KWB1@206389|Rhodocyclales	206389|Rhodocyclales	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
k59_1828136_2	580332.Slit_1049	6.35e-07	50.1	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,44VHC@713636|Nitrosomonadales	28216|Betaproteobacteria	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
k59_67098_1	1033736.CAHK01000024_gene1855	7.31e-134	412.0	COG2812@1|root,COG2812@2|Bacteria,2GJKA@201174|Actinobacteria,4F90I@85019|Brevibacteriaceae	201174|Actinobacteria	L	DNA polymerase III subunits gamma and tau domain III	dnaX	GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
k59_1414668_1	68170.KL590535_gene3762	4.57e-35	134.0	COG1277@1|root,COG1277@2|Bacteria,2ID14@201174|Actinobacteria,4E7AP@85010|Pseudonocardiales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_1179593_2	246197.MXAN_1844	2.3e-36	132.0	COG3501@1|root,COG3501@2|Bacteria,1R540@1224|Proteobacteria,42Q1X@68525|delta/epsilon subdivisions,2WM75@28221|Deltaproteobacteria,2YWGN@29|Myxococcales	28221|Deltaproteobacteria	S	Baseplate assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1179593_3	1009370.ALO_12301	2.57e-20	94.0	COG0553@1|root,COG0827@1|root,COG0553@2|Bacteria,COG0827@2|Bacteria,1VMRR@1239|Firmicutes,4H73C@909932|Negativicutes	909932|Negativicutes	L	Type III restriction enzyme, res subunit	-	-	-	-	-	-	-	-	-	-	-	-	ResIII
k59_651427_1	105559.Nwat_0645	8.11e-97	288.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,1WWC1@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM FeS assembly ATPase SufC	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
k59_827206_1	1267005.KB911263_gene1291	1.68e-59	197.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,3N69C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Sigma-54 interaction domain	ntrC	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat
k59_360570_1	395493.BegalDRAFT_2998	5.9e-18	79.0	2D186@1|root,32TA3@2|Bacteria,1N5ZE@1224|Proteobacteria,1S92Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_360570_2	187272.Mlg_2482	3.65e-39	141.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1WX4Z@135613|Chromatiales	135613|Chromatiales	S	AI-2E family transporter	-	-	-	ko:K03548	-	-	-	-	ko00000,ko02000	2.A.86.1	-	-	AI-2E_transport
k59_416317_1	1408254.T458_18495	3.87e-32	124.0	COG1012@1|root,COG1012@2|Bacteria,1UHQT@1239|Firmicutes,4IS6J@91061|Bacilli,277DN@186822|Paenibacillaceae	91061|Bacilli	C	Aldehyde dehydrogenase family	acdH	-	1.1.1.1,1.2.1.10,1.2.1.87	ko:K04072,ko:K13922	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00640,map00650,map01100,map01110,map01120,map01130,map01220	-	R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927,R09097	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh
k59_1120208_1	680198.SCAB_87071	1.18e-10	67.8	COG0745@1|root,COG1511@1|root,COG2203@1|root,COG4251@1|root,COG0745@2|Bacteria,COG1511@2|Bacteria,COG2203@2|Bacteria,COG4251@2|Bacteria,2GKQX@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,Response_reg
k59_67110_1	335543.Sfum_1582	5.56e-100	299.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,42MIX@68525|delta/epsilon subdivisions,2WJ5K@28221|Deltaproteobacteria,2MR47@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_710045_1	1177154.Y5S_03501	2.47e-48	176.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,1RPH9@1236|Gammaproteobacteria,1XHU5@135619|Oceanospirillales	135619|Oceanospirillales	E	COG1305 Transglutaminase-like enzymes	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
k59_475232_1	267608.RSp1201	3.71e-24	97.8	COG3637@1|root,COG3637@2|Bacteria,1N7IC@1224|Proteobacteria,2VVZ0@28216|Betaproteobacteria,1K72N@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	pagL	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008653,GO:0009279,GO:0009311,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0016788,GO:0019637,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0042802,GO:0042803,GO:0043170,GO:0044237,GO:0044238,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044425,GO:0044462,GO:0044464,GO:0046493,GO:0046983,GO:0050528,GO:0052689,GO:0071704,GO:0071944,GO:1901135,GO:1901269,GO:1903509	-	ko:K12976	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	PagL
k59_475232_2	1123518.ARWI01000001_gene1711	4.55e-56	186.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,45ZWY@72273|Thiotrichales	72273|Thiotrichales	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_888917_1	1131269.AQVV01000011_gene2518	2.14e-34	137.0	COG0188@1|root,COG0188@2|Bacteria	2|Bacteria	L	DNA topoisomerase II activity	parC	GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363	5.99.1.3	ko:K02469,ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_122993_2	439235.Dalk_1431	4.18e-44	150.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,42QWG@68525|delta/epsilon subdivisions,2WN1U@28221|Deltaproteobacteria,2MICR@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_710047_2	1266925.JHVX01000004_gene1223	4.91e-24	98.2	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2WFRY@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
k59_241967_1	446466.Cfla_3404	8.5e-162	461.0	COG4213@1|root,COG4213@2|Bacteria,2GKRE@201174|Actinobacteria,4F0VI@85016|Cellulomonadaceae	201174|Actinobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10546	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	Peripla_BP_4
k59_241969_1	686340.Metal_2681	3.73e-52	178.0	COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,1T1NH@1236|Gammaproteobacteria,1XEBV@135618|Methylococcales	135618|Methylococcales	EGP	PFAM Major Facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
k59_1473736_1	590998.Celf_1971	2.9e-166	474.0	COG0192@1|root,COG0192@2|Bacteria,2GJ4U@201174|Actinobacteria,4F0YK@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_1828169_1	477974.Daud_0175	8.61e-84	280.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,25ZY7@186807|Peptococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_67130_1	713587.THITH_07135	1.05e-41	143.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria,1WYWI@135613|Chromatiales	135613|Chromatiales	KT	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
k59_1062811_2	1396418.BATQ01000189_gene762	1.87e-49	171.0	COG3344@1|root,COG3344@2|Bacteria,46TQ6@74201|Verrucomicrobia	74201|Verrucomicrobia	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_241977_1	765910.MARPU_01110	1.75e-116	356.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1WWWW@135613|Chromatiales	135613|Chromatiales	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
k59_299297_1	1122962.AULH01000015_gene770	2.48e-82	252.0	COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,2TUPZ@28211|Alphaproteobacteria,36XR9@31993|Methylocystaceae	28211|Alphaproteobacteria	E	N-formylglutamate amidohydrolase	MA20_06380	-	3.5.1.68	ko:K01458	ko00340,ko00630,map00340,map00630	-	R00525	RC00165,RC00323	ko00000,ko00001,ko01000	-	-	-	FGase
k59_123001_2	926692.AZYG01000040_gene1536	1.06e-24	107.0	COG1560@1|root,COG1560@2|Bacteria,1TT7A@1239|Firmicutes,24HMK@186801|Clostridia,3WANH@53433|Halanaerobiales	186801|Clostridia	M	PFAM Bacterial lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_360597_1	1209072.ALBT01000061_gene983	3.36e-37	134.0	COG3161@1|root,COG3161@2|Bacteria,1N8BF@1224|Proteobacteria,1SDX2@1236|Gammaproteobacteria,1FHHG@10|Cellvibrio	1236|Gammaproteobacteria	H	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway	ubiC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008813,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.1.3.40	ko:K03181	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R01302	RC00491,RC02148	ko00000,ko00001,ko00002,ko01000	-	-	iZ_1308.Z5638	Chor_lyase
k59_360597_2	395493.BegalDRAFT_1199	7.17e-58	188.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,4602J@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_651452_2	765911.Thivi_3088	9.24e-16	74.7	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1WW5V@135613|Chromatiales	135613|Chromatiales	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
k59_1590149_2	68223.JNZY01000010_gene1938	1.81e-157	449.0	COG4989@1|root,COG4989@2|Bacteria,2GM3C@201174|Actinobacteria	201174|Actinobacteria	S	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1590149_3	1227261.HMPREF0043_02272	2.01e-12	71.2	2BA6N@1|root,323KN@2|Bacteria,2H8A6@201174|Actinobacteria,4D6NN@85005|Actinomycetales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1355725_1	1095772.CAHH01000042_gene1201	1.71e-48	173.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,2GM21@201174|Actinobacteria	201174|Actinobacteria	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	fmu	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
k59_947855_1	1492922.GY26_13880	5.48e-05	44.7	COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria,1J5QX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Phosphoserine phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
k59_947855_2	1265502.KB905978_gene490	3.14e-32	125.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,2VK1S@28216|Betaproteobacteria,4ACFA@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	btuC	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
k59_1355727_1	244582.JQAK01000001_gene747	4.81e-25	107.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2TQNY@28211|Alphaproteobacteria,47EV3@766|Rickettsiales	766|Rickettsiales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_181746_1	1397528.Q671_07845	3.51e-62	195.0	COG5615@1|root,COG5615@2|Bacteria,1N3BK@1224|Proteobacteria,1T0D6@1236|Gammaproteobacteria,1XRQ9@135619|Oceanospirillales	135619|Oceanospirillales	S	Copper resistance protein D	-	-	-	-	-	-	-	-	-	-	-	-	CopD
k59_1238871_1	439235.Dalk_1236	6.56e-105	310.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,42N4U@68525|delta/epsilon subdivisions,2WJR7@28221|Deltaproteobacteria,2MHSN@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
k59_827249_1	446468.Ndas_3922	6.11e-112	339.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4EGMP@85012|Streptosporangiales	201174|Actinobacteria	C	Fumarate reductase flavoprotein C-term	sdhA	-	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_592735_2	426114.THI_3096	2.41e-08	53.1	COG3462@1|root,COG3462@2|Bacteria,1NGXC@1224|Proteobacteria,2VY74@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
k59_1766378_1	468556.AQYG01000037_gene2723	1.86e-06	54.3	COG0406@1|root,COG0406@2|Bacteria,2GJYU@201174|Actinobacteria,4GAD0@85026|Gordoniaceae	201174|Actinobacteria	G	Phosphoglycerate mutase family	gpmB	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237	3.1.3.85,5.4.2.11	ko:K01834,ko:K22306	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
k59_1179645_1	614083.AWQR01000014_gene2466	1.92e-19	85.5	COG0625@1|root,COG0625@2|Bacteria,1RD2G@1224|Proteobacteria,2VRS9@28216|Betaproteobacteria,4ADMR@80864|Comamonadaceae	28216|Betaproteobacteria	O	Glutathione S-transferase	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_N_3
k59_1421136_2	1380356.JNIK01000002_gene4843	2.25e-07	53.1	COG0582@1|root,COG0582@2|Bacteria,2GTYQ@201174|Actinobacteria,4EW1T@85013|Frankiales	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
k59_716310_1	1149133.ppKF707_6095	3.23e-30	121.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_188066_1	247633.GP2143_01062	5.2e-23	98.6	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1J4R8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022607,GO:0022611,GO:0022613,GO:0022618,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0043021,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0065003,GO:0065007,GO:0070925,GO:0071826,GO:0071840,GO:0090069,GO:0090071,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_188066_2	380394.Lferr_0459	1.61e-10	61.6	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria,2NBRR@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	-	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
k59_1713467_1	1217718.ALOU01000007_gene1259	1.66e-77	241.0	COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2VM5U@28216|Betaproteobacteria,1KF02@119060|Burkholderiaceae	28216|Betaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
k59_1125304_1	300852.55772399	3.38e-27	110.0	COG2865@1|root,COG2865@2|Bacteria,1WIVH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_4
k59_481077_1	1123288.SOV_1c09240	2e-42	164.0	COG3210@1|root,COG4733@1|root,COG5295@1|root,COG3210@2|Bacteria,COG4733@2|Bacteria,COG5295@2|Bacteria,1U3AW@1239|Firmicutes,4H2WE@909932|Negativicutes	909932|Negativicutes	U	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Glug,Haemagg_act
k59_956206_1	1005048.CFU_2876	5.23e-08	58.2	COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,2VMZQ@28216|Betaproteobacteria,47245@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	negative regulator of sigma E activity	rseB	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	MucB_RseB,MucB_RseB_C
k59_1308346_2	1112217.PPL19_14000	1.26e-50	169.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008033,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016070,GO:0016740,GO:0016765,GO:0019222,GO:0031323,GO:0031326,GO:0032268,GO:0033554,GO:0034248,GO:0034470,GO:0034605,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043555,GO:0044237,GO:0044238,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0051716,GO:0052381,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990497,GO:2000112,GO:2000765	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
k59_1713474_1	765913.ThidrDRAFT_0290	1.85e-116	366.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales	135613|Chromatiales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1186188_1	1197706.AKKK01000006_gene1206	3.71e-43	144.0	COG3070@1|root,COG3070@2|Bacteria,2IRAD@201174|Actinobacteria	201174|Actinobacteria	K	TfoX N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
k59_481084_2	1335757.SPICUR_01535	9.88e-23	91.7	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,1WYPW@135613|Chromatiales	135613|Chromatiales	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
k59_598270_1	266835.14022074	1.45e-07	60.5	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2TRKK@28211|Alphaproteobacteria,43HAU@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Mechanosensitive ion channel	kefA	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	DUF3772,MS_channel
k59_772859_1	66377.JOBH01000018_gene2434	9.88e-87	286.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_716339_1	269797.Mbar_A1370	1.95e-47	167.0	COG4012@1|root,arCOG04365@2157|Archaea,2XUWU@28890|Euryarchaeota,2N9HK@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative pyruvate format-lyase activating enzyme (DUF1786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1786
k59_657705_1	1121918.ARWE01000001_gene3458	9.53e-96	292.0	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,42KZP@68525|delta/epsilon subdivisions,2WKSV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_368968_1	525904.Tter_1074	1.12e-62	217.0	COG0587@1|root,COG0587@2|Bacteria,2NNVY@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase	dnaE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_422353_1	232346.JHQL01000004_gene1661	6.47e-14	77.8	COG1401@1|root,COG3440@1|root,COG1401@2|Bacteria,COG3440@2|Bacteria,1QGT7@1224|Proteobacteria,1RSHW@1236|Gammaproteobacteria,1XIY9@135619|Oceanospirillales	135619|Oceanospirillales	V	COG1401 GTPase subunit of restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1655960_1	314278.NB231_13206	2.66e-16	81.6	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1WW09@135613|Chromatiales	135613|Chromatiales	CH	Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	-	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_1071968_1	318167.Sfri_2286	2.42e-37	138.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,2QAGX@267890|Shewanellaceae	1236|Gammaproteobacteria	C	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_1071968_2	1265313.HRUBRA_01919	4.49e-50	162.0	COG1006@1|root,COG1006@2|Bacteria,1RGU1@1224|Proteobacteria,1S6BB@1236|Gammaproteobacteria,1J68T@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
k59_1125323_1	187272.Mlg_1362	3.22e-108	331.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1WWEF@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_422358_1	870187.Thini_1237	6.66e-94	289.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria,45ZTP@72273|Thiotrichales	72273|Thiotrichales	S	Flavocytochrome c sulphide dehydrogenase, flavin-binding	-	-	1.8.2.3	ko:K17229	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2
k59_1537487_1	1049564.TevJSym_ad00290	7.77e-67	230.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,1J980@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2309)	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k59_481105_1	1123393.KB891332_gene2745	4.5e-107	321.0	COG2203@1|root,COG2203@2|Bacteria,1PP8V@1224|Proteobacteria,2VKHH@28216|Betaproteobacteria,1KSKH@119069|Hydrogenophilales	119069|Hydrogenophilales	T	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,Putative_PNPOx
k59_481105_2	1123392.AQWL01000002_gene1721	2.66e-18	80.5	COG3576@1|root,COG3576@2|Bacteria,1PT76@1224|Proteobacteria,2WAES@28216|Betaproteobacteria,1KT2I@119069|Hydrogenophilales	119069|Hydrogenophilales	S	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_897229_1	1267005.KB911259_gene3832	4.12e-77	243.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRCI@28211|Alphaproteobacteria,3N6JF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX1	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_1836605_1	1517416.IDAT_09255	1.55e-50	168.0	COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,1T1GE@1236|Gammaproteobacteria,2QF8T@267893|Idiomarinaceae	1236|Gammaproteobacteria	P	Integral membrane protein TerC family	ygdQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	TerC
k59_598286_1	382464.ABSI01000013_gene1768	8.84e-83	274.0	COG0187@1|root,COG0187@2|Bacteria,46SDH@74201|Verrucomicrobia,2IU0E@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_1713499_1	941449.dsx2_0772	1.13e-70	229.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,2M7ZB@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_75499_1	794903.OPIT5_19065	2.03e-42	148.0	COG2738@1|root,COG2738@2|Bacteria,46THF@74201|Verrucomicrobia,3K7WD@414999|Opitutae	414999|Opitutae	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K06973	-	-	-	-	ko00000	-	-	-	Zn_peptidase_2
k59_188102_2	1235279.C772_02740	4.89e-14	79.0	COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,4HASP@91061|Bacilli,26E7E@186818|Planococcaceae	91061|Bacilli	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_253550_1	911045.PSE_2743	1.22e-21	98.6	COG2357@1|root,COG2357@2|Bacteria,1RDE9@1224|Proteobacteria,2UHFA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Region found in RelA / SpoT proteins	-	-	-	-	-	-	-	-	-	-	-	-	RelA_SpoT
k59_539967_1	29581.BW37_01018	7.8e-52	179.0	COG4782@1|root,COG4782@2|Bacteria,1MVAD@1224|Proteobacteria,2VV6E@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Alpha/beta hydrolase of unknown function (DUF900)	-	-	-	-	-	-	-	-	-	-	-	-	DUF900
k59_1308392_1	765912.Thimo_3321	7.83e-101	300.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,1WX9J@135613|Chromatiales	135613|Chromatiales	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_1836609_2	439375.Oant_2262	5.93e-15	70.5	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2U6Z9@28211|Alphaproteobacteria,1J2VN@118882|Brucellaceae	28211|Alphaproteobacteria	O	Redoxin	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_1247428_1	911045.PSE_2845	0.000162	43.9	COG1360@1|root,COG3455@1|root,COG1360@2|Bacteria,COG3455@2|Bacteria,1MU13@1224|Proteobacteria,2TTGF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	Protein conserved in bacteria	impK	-	-	ko:K11892	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	DotU,OmpA
k59_1247428_2	1123401.JHYQ01000001_gene1797	8.23e-52	179.0	COG0220@1|root,COG0220@2|Bacteria,1QYIP@1224|Proteobacteria,1T5B9@1236|Gammaproteobacteria,463MF@72273|Thiotrichales	72273|Thiotrichales	J	Predicted methyltransferase regulatory domain	-	-	-	-	-	-	-	-	-	-	-	-	MethyTransf_Reg
k59_1836612_1	546274.EIKCOROL_00668	1.28e-54	189.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,2KPUY@206351|Neisseriales	206351|Neisseriales	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
k59_1186225_1	1283300.ATXB01000001_gene2448	7.75e-123	375.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1XE70@135618|Methylococcales	135618|Methylococcales	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HTH_12,OB_RNB,RNB,S1
k59_1483507_1	582899.Hden_2948	7.2e-71	228.0	COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2TS0X@28211|Alphaproteobacteria,3N62Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	nrt	-	-	ko:K15576,ko:K22067	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000,ko02022	3.A.1.16.1,3.A.1.16.2	-	-	NMT1_2
k59_481876_1	399739.Pmen_0154	3.82e-140	425.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1YD1K@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1837645_1	187272.Mlg_2287	2.02e-88	271.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,1WX82@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_76469_1	1122603.ATVI01000007_gene1516	9.46e-27	119.0	COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,1X5V0@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
k59_1483515_1	1121403.AUCV01000020_gene3109	1.87e-44	162.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1QUMN@1224|Proteobacteria,43BMA@68525|delta/epsilon subdivisions,2X6ZG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	hdrA	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
k59_957286_2	1387312.BAUS01000002_gene393	3.63e-31	115.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2VR66@28216|Betaproteobacteria,2KMQV@206350|Nitrosomonadales	206350|Nitrosomonadales	U	type II secretion system protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
k59_957286_3	713586.KB900536_gene2469	0.000394	43.5	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1WWYV@135613|Chromatiales	135613|Chromatiales	NU	Type II secretion system	-	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
k59_305675_1	156889.Mmc1_1035	6.04e-40	152.0	COG0642@1|root,COG0745@1|root,COG2199@1|root,COG2202@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,HATPase_c,HisKA,Hpt,NMT1,PAS,PAS_9,Response_reg
k59_1596677_1	1254432.SCE1572_51635	3e-15	78.2	COG3250@1|root,COG3250@2|Bacteria,1R5U9@1224|Proteobacteria	1224|Proteobacteria	G	Vitamin K-dependent gamma-carboxylase	-	-	-	-	-	-	-	-	-	-	-	-	VKG_Carbox
k59_254509_1	1123392.AQWL01000002_gene1819	1.98e-28	113.0	COG2262@1|root,COG2262@2|Bacteria,1QV04@1224|Proteobacteria,2WGNW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function (DUF3482)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3482,MMR_HSR1
k59_1483524_1	1122604.JONR01000006_gene2736	5.84e-55	197.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,1X43U@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
k59_834276_1	246197.MXAN_0222	3.63e-134	392.0	COG0604@1|root,COG0604@2|Bacteria,1QY04@1224|Proteobacteria,43AHJ@68525|delta/epsilon subdivisions,2X5XS@28221|Deltaproteobacteria,2YUNY@29|Myxococcales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
k59_1837664_1	768671.ThimaDRAFT_1240	7.93e-74	228.0	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,1RMQ2@1236|Gammaproteobacteria,1WXB5@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
k59_20967_1	471853.Bcav_2453	2.83e-206	624.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria	201174|Actinobacteria	L	dead DEAH box helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
k59_1656718_1	1121405.dsmv_2950	1.37e-78	251.0	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,42QF7@68525|delta/epsilon subdivisions,2WJAU@28221|Deltaproteobacteria,2MJ5H@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07644	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS_9,Response_reg
k59_1186947_1	648757.Rvan_1139	2.23e-93	302.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2TSVH@28211|Alphaproteobacteria,3N6I3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Putative amidoligase enzyme (DUF2126)	MA20_16195	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
k59_1309429_1	1210884.HG799464_gene10801	8.49e-23	101.0	COG4948@1|root,COG4948@2|Bacteria,2IX42@203682|Planctomycetes	203682|Planctomycetes	M	Mandelate racemase muconate lactonizing enzyme	-	-	5.1.1.20,5.5.1.1	ko:K01856,ko:K19802	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	M00568	R05300,R05390,R06989,R08116,R09229,R10938	RC00903,RC01038,RC01108,RC01321,RC01356,RC03309	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_254516_1	471853.Bcav_2250	1.04e-116	343.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria	201174|Actinobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_188854_1	519989.ECTPHS_06872	1.77e-64	209.0	COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,1RPY4@1236|Gammaproteobacteria,1WVV1@135613|Chromatiales	135613|Chromatiales	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
k59_370035_1	367299.JOEE01000003_gene3031	8.99e-167	478.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4FEHJ@85021|Intrasporangiaceae	201174|Actinobacteria	I	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	pccB	GO:0003674,GO:0003824,GO:0003989,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009317,GO:0009987,GO:0015977,GO:0016020,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0030312,GO:0032787,GO:0032991,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:0071944,GO:0072329,GO:1901575,GO:1902494	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_898294_1	471853.Bcav_3814	4.32e-26	100.0	COG2212@1|root,COG2212@2|Bacteria	2|Bacteria	P	antiporter activity	mrpF	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
k59_898294_2	590998.Celf_0331	2.48e-41	141.0	COG1320@1|root,COG1320@2|Bacteria,2IQXD@201174|Actinobacteria,4F1FT@85016|Cellulomonadaceae	201174|Actinobacteria	P	TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit	mrpG	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_1538318_1	1143323.M787_0557	3.15e-16	82.4	COG0215@1|root,COG0215@2|Bacteria,2JFNB@204428|Chlamydiae	204428|Chlamydiae	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
k59_76517_1	882083.SacmaDRAFT_0617	4.51e-118	345.0	COG0175@1|root,COG0175@2|Bacteria,2GK5Y@201174|Actinobacteria,4E928@85010|Pseudonocardiales	201174|Actinobacteria	EH	sulfate reduction	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1362354_1	926550.CLDAP_29370	6.47e-25	105.0	COG0354@1|root,COG0354@2|Bacteria,2G8ZM@200795|Chloroflexi	200795|Chloroflexi	S	Glycine cleavage T-protein C-terminal barrel domain	-	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_1483550_1	1265313.HRUBRA_02024	1.76e-45	156.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,1RMR8@1236|Gammaproteobacteria,1J5YA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
k59_1483550_2	2340.JV46_28430	4.4e-82	258.0	COG4651@1|root,COG4651@2|Bacteria,1QUQS@1224|Proteobacteria,1T21E@1236|Gammaproteobacteria,1J57I@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Kef-type K transport	kefC_1	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1125979_1	743718.Isova_0152	8.9e-52	179.0	COG1112@1|root,COG3662@1|root,COG1112@2|Bacteria,COG3662@2|Bacteria,2GJD2@201174|Actinobacteria,4F59G@85017|Promicromonosporaceae	201174|Actinobacteria	L	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
k59_1309460_1	2340.JV46_19050	5.69e-32	129.0	COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,1T214@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3306,Fer4,Fer4_10,Fer4_6,Fer4_7
k59_481920_1	289376.THEYE_A2073	3.38e-07	57.8	COG0455@1|root,COG0455@2|Bacteria,3J0JR@40117|Nitrospirae	40117|Nitrospirae	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31
k59_1538330_1	1265505.ATUG01000002_gene969	6.56e-16	77.0	COG0412@1|root,COG0412@2|Bacteria,1RD65@1224|Proteobacteria	1224|Proteobacteria	Q	Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1073371_1	880073.Calab_1044	0.000189	45.1	COG0421@1|root,COG0421@2|Bacteria,2NNTV@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
k59_1073371_2	452637.Oter_2660	8.91e-19	84.0	COG5061@1|root,COG5061@2|Bacteria	2|Bacteria	OU	protein folding in endoplasmic reticulum	satE	-	-	ko:K19134	-	-	-	-	ko00000,ko02048	-	-	-	DUF3307
k59_898314_1	1035308.AQYY01000001_gene2689	2.85e-30	110.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	HTH_3,HTH_31,NTP_transf_2
k59_1362368_1	1304865.JAGF01000001_gene2564	5.86e-103	315.0	COG0642@1|root,COG2205@2|Bacteria,2I3HN@201174|Actinobacteria,4F0KP@85016|Cellulomonadaceae	201174|Actinobacteria	T	SMART ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_964154_1	194867.ALBQ01000011_gene172	7.4e-31	122.0	COG2271@1|root,COG2271@2|Bacteria,1MV04@1224|Proteobacteria,2U253@28211|Alphaproteobacteria,2K1NR@204457|Sphingomonadales	204457|Sphingomonadales	G	Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
k59_27242_1	356851.JOAN01000015_gene2597	1.03e-47	189.0	COG2706@1|root,COG2755@1|root,COG3209@1|root,COG2706@2|Bacteria,COG2755@2|Bacteria,COG3209@2|Bacteria,2GMBB@201174|Actinobacteria,4DBAV@85008|Micromonosporales	201174|Actinobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PT-HINT,RHS_repeat,Ricin_B_lectin,VCBS
k59_1080651_1	1207063.P24_05857	3.97e-22	95.9	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,2JQKH@204441|Rhodospirillales	204441|Rhodospirillales	S	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_1080651_2	1007105.PT7_1519	4.49e-32	120.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2VMR0@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TRAP transporter solute receptor, TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_310623_1	555779.Dthio_PD1799	1.08e-56	202.0	COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2M8T9@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	ATPase BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
k59_1192874_1	1095767.CAHD01000126_gene1207	2.25e-82	259.0	COG1169@1|root,COG1169@2|Bacteria,2GKE8@201174|Actinobacteria,4F0VS@85016|Cellulomonadaceae	201174|Actinobacteria	HQ	chorismate binding enzyme	menF	-	5.4.4.2	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
k59_262901_1	349521.HCH_03760	7.87e-83	274.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XH4Q@135619|Oceanospirillales	135619|Oceanospirillales	V	efflux pump	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1720191_1	1121405.dsmv_2390	1.12e-153	437.0	COG3385@1|root,COG3385@2|Bacteria,1R8CS@1224|Proteobacteria,42P9F@68525|delta/epsilon subdivisions,2WKTA@28221|Deltaproteobacteria,2MJAY@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_2
k59_1192878_1	1713.JOFV01000002_gene706	1.41e-112	331.0	COG1682@1|root,COG1682@2|Bacteria,2GP5K@201174|Actinobacteria,4F2UM@85016|Cellulomonadaceae	201174|Actinobacteria	GM	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_965483_1	1123073.KB899241_gene2677	1.57e-64	214.0	COG0318@1|root,COG0318@2|Bacteria,1MXPB@1224|Proteobacteria,1RRD5@1236|Gammaproteobacteria,1X4JQ@135614|Xanthomonadales	135614|Xanthomonadales	IQ	Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_965483_2	666685.R2APBS1_3767	8.73e-14	68.6	COG0764@1|root,COG0764@2|Bacteria,1NGGK@1224|Proteobacteria,1SJ6T@1236|Gammaproteobacteria,1X85H@135614|Xanthomonadales	135614|Xanthomonadales	I	3-hydroxymyristoyl 3-hydroxydecanoyl-(acyl carrier protein)	-	-	-	-	-	-	-	-	-	-	-	-	FabA,PS-DH
k59_84746_1	1163407.UU7_11230	3.17e-08	62.0	COG0457@1|root,COG0745@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0745@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9I0@135614|Xanthomonadales	135614|Xanthomonadales	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_8
k59_1082034_2	2340.JV46_23290	1.24e-59	190.0	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,1S40Q@1236|Gammaproteobacteria,1J5QA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_1490817_1	485913.Krac_2401	3.32e-12	67.0	COG0053@1|root,COG0053@2|Bacteria,2G5MK@200795|Chloroflexi	200795|Chloroflexi	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_1490817_2	498761.HM1_1803	5.88e-26	106.0	COG1271@1|root,COG1271@2|Bacteria,1TRH4@1239|Firmicutes,24D51@186801|Clostridia	186801|Clostridia	C	oxidase, subunit	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_1317766_1	1304885.AUEY01000005_gene842	3.84e-85	267.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria,2MJG3@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_1544196_1	1232410.KI421426_gene1458	2.99e-72	244.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43U04@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_194730_1	469371.Tbis_0693	2.49e-36	150.0	COG1674@1|root,COG1674@2|Bacteria,2GJBR@201174|Actinobacteria,4DXDB@85010|Pseudonocardiales	201174|Actinobacteria	D	FtsK/SpoIIIE family	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_SpoIIIE
k59_664385_1	1123251.ATWM01000001_gene645	5.17e-43	153.0	COG1131@1|root,COG1131@2|Bacteria,2IBJD@201174|Actinobacteria,4FIR1@85021|Intrasporangiaceae	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_1013394_1	1463879.JOHP01000003_gene5656	4.84e-53	181.0	COG0706@1|root,COG0706@2|Bacteria,2GJBU@201174|Actinobacteria	201174|Actinobacteria	U	Membrane protein insertase, YidC Oxa1 family	yidC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
k59_1778782_1	765910.MARPU_16330	5.35e-23	97.4	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1WX9W@135613|Chromatiales	135613|Chromatiales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
k59_1778782_2	1355368.JART01000021_gene1624	5.04e-64	211.0	COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,42MI1@68525|delta/epsilon subdivisions,2YMPQ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	I	Sulfatase	eptA	-	2.7.8.43	ko:K03760	ko01503,map01503	M00722	R11555,R11556,R11557	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DUF1705,Sulfatase
k59_965503_1	2340.JV46_08850	4.29e-116	347.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,1J5CE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL
k59_136143_1	396588.Tgr7_1849	2.94e-198	559.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,1WW57@135613|Chromatiales	135613|Chromatiales	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
k59_136143_2	471857.Svir_22420	1.08e-30	121.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4DY9U@85010|Pseudonocardiales	201174|Actinobacteria	C	aconitate hydratase	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_378320_1	590998.Celf_2867	1.62e-88	274.0	COG0836@1|root,COG0836@2|Bacteria,2GIRM@201174|Actinobacteria,4F20H@85016|Cellulomonadaceae	201174|Actinobacteria	M	Nucleotidyl transferase	manC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_378320_2	935839.JAGJ01000010_gene372	6.26e-59	196.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria,4F40D@85017|Promicromonosporaceae	201174|Actinobacteria	S	Peptidase family M20/M25/M40	amiA	-	-	ko:K01436,ko:K06048	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_722822_1	1385521.N803_11885	2.82e-33	120.0	COG3742@1|root,COG3742@2|Bacteria,2IS39@201174|Actinobacteria,4FJ9T@85021|Intrasporangiaceae	201174|Actinobacteria	S	PIN domain	-	-	-	ko:K19686	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
k59_965504_1	933262.AXAM01000011_gene1755	5.24e-31	122.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42P5P@68525|delta/epsilon subdivisions,2WITN@28221|Deltaproteobacteria,2MJ25@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_9,Pyr_redox_2
k59_965504_2	1121405.dsmv_1953	2.49e-115	341.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,2MJ3H@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_194744_1	1121013.P873_00835	1.82e-06	55.1	COG0515@1|root,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria,1S0IU@1236|Gammaproteobacteria,1X4DU@135614|Xanthomonadales	135614|Xanthomonadales	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12
k59_84774_1	1210884.HG799469_gene14206	1.18e-30	124.0	COG2433@1|root,COG2433@2|Bacteria,2IYQC@203682|Planctomycetes	203682|Planctomycetes	S	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_722831_1	1112217.PPL19_11047	7.14e-46	162.0	COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_1256150_1	1230342.CTM_01465	1.61e-20	96.3	COG1145@1|root,COG4624@1|root,COG1145@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,24BF5@186801|Clostridia,36E2Y@31979|Clostridiaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_7,PAS
k59_194746_1	272568.GDI0049	1.94e-18	85.9	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2TRHP@28211|Alphaproteobacteria,2JPQQ@204441|Rhodospirillales	204441|Rhodospirillales	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_194746_2	519989.ECTPHS_03909	1.1e-32	120.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yqgF	GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
k59_311754_1	572477.Alvin_2888	7.72e-69	223.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1WVY3@135613|Chromatiales	135613|Chromatiales	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_778455_1	1267005.KB911255_gene2897	1.33e-102	315.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,3N7Z7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Extracellular solute-binding protein	yejA	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
k59_428999_1	522306.CAP2UW1_1750	2.79e-127	370.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2VH6Y@28216|Betaproteobacteria	28216|Betaproteobacteria	P	phosphate transport system permease	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_965528_1	401053.AciPR4_0575	7.98e-17	83.6	COG2204@1|root,COG2204@2|Bacteria,3Y41F@57723|Acidobacteria,2JIZR@204432|Acidobacteriia	204432|Acidobacteriia	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_906623_1	1121104.AQXH01000004_gene92	5.61e-32	129.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IT7X@117747|Sphingobacteriia	976|Bacteroidetes	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,HTH_18,TPR_2,TPR_8
k59_487770_1	1049564.TevJSym_ab00160	4.35e-88	263.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1J64K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1662839_1	1005995.GTPT_2252	7.95e-45	155.0	COG0518@1|root,COG0518@2|Bacteria,1MV9U@1224|Proteobacteria,1S49E@1236|Gammaproteobacteria,4BUMW@82986|Tatumella	1236|Gammaproteobacteria	F	Peptidase C26	guaA_2	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
k59_311767_1	675635.Psed_5463	2.16e-14	72.8	COG0250@1|root,COG0250@2|Bacteria,2GJFW@201174|Actinobacteria,4E05Z@85010|Pseudonocardiales	201174|Actinobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusG
k59_311767_2	471853.Bcav_3163	1.36e-24	95.1	COG0690@1|root,COG0690@2|Bacteria,2GQFP@201174|Actinobacteria	201174|Actinobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
k59_1720240_1	1304865.JAGF01000001_gene1582	1.27e-149	441.0	COG0842@1|root,COG0842@2|Bacteria,2GN6S@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_1602441_1	1267533.KB906742_gene776	6.17e-85	275.0	COG3250@1|root,COG3250@2|Bacteria,3Y32Q@57723|Acidobacteria,2JHZD@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glyco_hydro_2_N
k59_1131332_1	95619.PM1_0213405	2.89e-59	206.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0003674,GO:0003824,GO:0003887,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1082093_1	1121405.dsmv_3411	7.35e-52	179.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,42NKY@68525|delta/epsilon subdivisions,2WJJG@28221|Deltaproteobacteria,2MHKD@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_664423_1	555778.Hneap_0971	9.3e-61	209.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_311773_1	713586.KB900536_gene2324	1.76e-82	251.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1WZW4@135613|Chromatiales	135613|Chromatiales	L	Endonuclease/Exonuclease/phosphatase family	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_604951_2	1192034.CAP_6065	5.36e-17	80.5	COG1061@1|root,COG3886@1|root,COG1061@2|Bacteria,COG3886@2|Bacteria,1MV9F@1224|Proteobacteria,42NS1@68525|delta/epsilon subdivisions,2WQXY@28221|Deltaproteobacteria,2YWZQ@29|Myxococcales	28221|Deltaproteobacteria	KL	Domain of unknown function (DUF3427)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3427,Helicase_C,PLDc_2,ResIII
k59_263009_1	765911.Thivi_3723	5.59e-90	275.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1WW40@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM Tyrosine recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_84826_1	314230.DSM3645_13630	5.2e-63	217.0	COG1450@1|root,COG1450@2|Bacteria,2J2IJ@203682|Planctomycetes	203682|Planctomycetes	NU	Bacterial type II/III secretion system short domain	-	-	-	-	-	-	-	-	-	-	-	-	Secretin_N
k59_487791_1	349521.HCH_01903	7.4e-39	142.0	COG3977@1|root,COG3977@2|Bacteria,1MVRW@1224|Proteobacteria,1RNK1@1236|Gammaproteobacteria,1XHID@135619|Oceanospirillales	135619|Oceanospirillales	E	catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids	-	-	2.6.1.66	ko:K00835	ko00290,ko01100,ko01110,ko01130,map00290,map01100,map01110,map01130	-	R01215	RC00008,RC00036	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_487791_2	1224136.AMFN01000023_gene1894	8.7e-05	45.4	COG1011@1|root,COG1011@2|Bacteria,1N0I6@1224|Proteobacteria,1RQ41@1236|Gammaproteobacteria,283BU@191675|unclassified Enterobacteriaceae	1236|Gammaproteobacteria	S	Haloacid dehalogenase-like hydrolase	yigB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0018130,GO:0022611,GO:0032502,GO:0034641,GO:0042364,GO:0042578,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043726,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.3.102,3.1.3.104	ko:K20862	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00548,R07280	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2
k59_664439_1	543728.Vapar_4498	7.81e-89	275.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2VIE4@28216|Betaproteobacteria,4AJH7@80864|Comamonadaceae	28216|Betaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_840212_1	722419.PH505_ad00140	1.56e-23	107.0	COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,2PZDP@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_1845993_1	1713.JOFV01000001_gene1958	1.37e-51	169.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4F0T8@85016|Cellulomonadaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	regX3	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1013445_1	1238182.C882_1059	1.08e-116	350.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,2JPV0@204441|Rhodospirillales	204441|Rhodospirillales	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_136200_1	945713.IALB_0305	9.27e-35	121.0	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_84840_1	378806.STAUR_3533	2.74e-79	247.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42MUK@68525|delta/epsilon subdivisions,2X5CN@28221|Deltaproteobacteria,2YUF4@29|Myxococcales	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.31	ko:K02052,ko:K11072	ko02010,ko02024,map02010,map02024	M00193,M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11,3.A.1.11.1	-	-	ABC_tran,TOBE_2
k59_1846005_1	680198.SCAB_29961	1.53e-51	178.0	COG1653@1|root,COG1653@2|Bacteria,2I8TG@201174|Actinobacteria	201174|Actinobacteria	G	transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
k59_194797_1	1304865.JAGF01000001_gene1651	1.61e-85	280.0	COG0507@1|root,COG0507@2|Bacteria,2GJRK@201174|Actinobacteria	201174|Actinobacteria	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_30,TrwC
k59_1082128_2	1380391.JIAS01000011_gene5414	5.65e-42	152.0	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2TRT9@28211|Alphaproteobacteria,2JPUI@204441|Rhodospirillales	28211|Alphaproteobacteria	E	Oxidative deamination of D-amino acids	-	-	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO
k59_263044_1	319003.Bra1253DRAFT_06748	1.02e-100	303.0	COG2235@1|root,COG2235@2|Bacteria,1NCGV@1224|Proteobacteria,2TU0Z@28211|Alphaproteobacteria,3JWPM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Amidinotransferase	arcA	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
k59_194807_1	749414.SBI_00800	4.41e-30	120.0	COG0673@1|root,COG0673@2|Bacteria,2GJCY@201174|Actinobacteria	201174|Actinobacteria	G	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose)	iolG	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_722896_1	617140.AJZE01000078_gene1847	1.92e-46	166.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGA@1236|Gammaproteobacteria,1XXNF@135623|Vibrionales	135623|Vibrionales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1720279_1	686578.AFFX01000003_gene432	1.43e-69	219.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iSSON_1240.SSON_4131	Semialdhyde_dh,Semialdhyde_dhC
k59_1720279_2	270374.MELB17_20321	5.33e-20	92.4	2DA4I@1|root,32TUN@2|Bacteria,1N0WK@1224|Proteobacteria,1S6HI@1236|Gammaproteobacteria,467DY@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1720279_3	1318628.MARLIPOL_15712	3.08e-42	143.0	COG1664@1|root,COG1664@2|Bacteria,1PDPX@1224|Proteobacteria,1S9XY@1236|Gammaproteobacteria,46885@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG1664 Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_84864_1	96561.Dole_0268	4.73e-23	102.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria,2MHM6@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	nifM	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
k59_1317878_2	1255043.TVNIR_1238	1.62e-73	228.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,1RNH2@1236|Gammaproteobacteria,1WWM8@135613|Chromatiales	135613|Chromatiales	IQ	TIGRFAM acetoacetyl-CoA reductase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
k59_1450283_1	1463856.JOHY01000120_gene1079	2.39e-68	232.0	COG3250@1|root,COG3250@2|Bacteria,2I9Q2@201174|Actinobacteria	201174|Actinobacteria	G	Glycosyl hydrolases family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,RicinB_lectin_2
k59_158625_1	234267.Acid_5701	3.89e-37	136.0	COG2224@1|root,COG2224@2|Bacteria,3Y345@57723|Acidobacteria	57723|Acidobacteria	C	Isocitrate lyase family	-	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
k59_1215022_1	1347392.CCEZ01000049_gene1510	1.75e-28	115.0	COG1404@1|root,COG1404@2|Bacteria,1VD5C@1239|Firmicutes,24C2E@186801|Clostridia,36H8D@31979|Clostridiaceae	186801|Clostridia	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_1034347_1	1232410.KI421422_gene2086	4.83e-146	436.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TIGRFAM TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1450293_1	1123355.JHYO01000034_gene563	1.08e-63	219.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,36XHA@31993|Methylocystaceae	28211|Alphaproteobacteria	P	AcrB/AcrD/AcrF family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_158635_2	631362.Thi970DRAFT_01620	4.24e-81	243.0	COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,1S37E@1236|Gammaproteobacteria,1WWWB@135613|Chromatiales	135613|Chromatiales	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_1685297_1	269797.Mbar_A2393	2.54e-13	74.3	COG0609@1|root,arCOG01007@2157|Archaea,2XT1A@28890|Euryarchaeota,2N9H7@224756|Methanomicrobia	224756|Methanomicrobia	P	FecCD transport family	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	iAF692.Mbar_A1173	FecCD
k59_1281790_1	595460.RRSWK_01373	2.57e-69	233.0	COG0515@1|root,COG0515@2|Bacteria,2IXG3@203682|Planctomycetes	203682|Planctomycetes	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	HDOD,Pkinase,dCache_1
k59_1151299_1	547163.BN979_06261	1.39e-89	283.0	COG2373@1|root,COG2373@2|Bacteria,2H4M3@201174|Actinobacteria,236MB@1762|Mycobacteriaceae	201174|Actinobacteria	S	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,Catalase
k59_1624210_1	446466.Cfla_1119	3.43e-99	301.0	COG0064@1|root,COG0064@2|Bacteria,2GJJH@201174|Actinobacteria,4F0FH@85016|Cellulomonadaceae	201174|Actinobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_1685298_1	471853.Bcav_1260	5.48e-27	105.0	2DTCB@1|root,33JPI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1685298_2	1304865.JAGF01000001_gene2671	4.4e-36	137.0	COG0455@1|root,COG0455@2|Bacteria,2IARP@201174|Actinobacteria,4F1X2@85016|Cellulomonadaceae	201174|Actinobacteria	D	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
k59_216848_1	1245469.S58_22090	5.5e-08	54.3	COG1116@1|root,COG1116@2|Bacteria,1R53G@1224|Proteobacteria,2U0HV@28211|Alphaproteobacteria,3JV4G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ABC transporter	atsC	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
k59_216848_2	626887.J057_08586	6.21e-34	131.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,1S25T@1236|Gammaproteobacteria,46AP6@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	blaB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,NUDIX
k59_1516024_1	1121106.JQKB01000011_gene404	1.02e-19	90.9	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2TS2H@28211|Alphaproteobacteria,2JQV6@204441|Rhodospirillales	204441|Rhodospirillales	M	COG1560 Lauroyl myristoyl acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_451546_1	472759.Nhal_3792	2.1e-167	474.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_796840_1	1380354.JIAN01000011_gene3203	4.94e-87	264.0	COG1814@1|root,COG1814@2|Bacteria,2GIZ3@201174|Actinobacteria	201174|Actinobacteria	S	membrane	pcl	-	-	-	-	-	-	-	-	-	-	-	VIT1
k59_862304_2	1408444.JHYC01000030_gene1292	7.61e-37	138.0	COG0475@1|root,COG0475@2|Bacteria,1RB9F@1224|Proteobacteria,1S398@1236|Gammaproteobacteria,1JDR9@118969|Legionellales	118969|Legionellales	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1624227_1	1121405.dsmv_1484	2.09e-84	257.0	COG0407@1|root,COG0407@2|Bacteria,1PXIF@1224|Proteobacteria,42SKI@68525|delta/epsilon subdivisions,2WPBF@28221|Deltaproteobacteria,2MKAD@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_1624227_2	1121430.JMLG01000016_gene381	1.57e-25	97.8	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_1743110_1	596151.DesfrDRAFT_1726	1.01e-30	110.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42V9Q@68525|delta/epsilon subdivisions,2WRRT@28221|Deltaproteobacteria,2MCID@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_1743110_2	1218084.BBJK01000070_gene5026	3.35e-32	122.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2WGFK@28216|Betaproteobacteria,1K2CC@119060|Burkholderiaceae	28216|Betaproteobacteria	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	hprA	-	1.1.1.29,1.1.1.399,1.1.1.95	ko:K00018,ko:K00058	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00020,M00346	R00717,R01388,R01513	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_796842_1	326298.Suden_1813	4.2e-98	303.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2YQN3@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_745586_1	338966.Ppro_0188	2.73e-48	169.0	COG3385@1|root,COG3385@2|Bacteria,1R8CS@1224|Proteobacteria,42P9F@68525|delta/epsilon subdivisions,2WKTA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_2
k59_334774_1	574966.KB898647_gene2172	2.88e-36	139.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1XHCM@135619|Oceanospirillales	135619|Oceanospirillales	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_1107474_1	1304865.JAGF01000001_gene1993	1.01e-123	374.0	COG1299@1|root,COG1445@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,2GJU4@201174|Actinobacteria	201174|Actinobacteria	GT	Phosphotransferase System	fruA	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2,PTS_EIIC,PTS_IIB
k59_1624238_1	1318628.MARLIPOL_05410	3.25e-46	152.0	COG0745@1|root,COG0745@2|Bacteria,1RHCU@1224|Proteobacteria,1SBB6@1236|Gammaproteobacteria,46B2G@72275|Alteromonadaceae	1236|Gammaproteobacteria	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_862317_1	1304275.C41B8_05828	2.73e-82	257.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051301,GO:0051704,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_862317_2	1165096.ARWF01000001_gene174	6.54e-37	140.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VIAU@28216|Betaproteobacteria,2KMG1@206350|Nitrosomonadales	206350|Nitrosomonadales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_158673_1	215803.DB30_3249	1.8e-09	56.6	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,42TV9@68525|delta/epsilon subdivisions,2WNAN@28221|Deltaproteobacteria,2YV81@29|Myxococcales	28221|Deltaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_158673_2	1249627.D779_0109	3.11e-39	145.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1WXE2@135613|Chromatiales	135613|Chromatiales	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_862322_1	748280.NH8B_1724	3.29e-22	99.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2VH9C@28216|Betaproteobacteria,2KPYP@206351|Neisseriales	206351|Neisseriales	S	Permease, YjgP YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_745600_1	1249627.D779_0258	9.47e-66	222.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1WXQF@135613|Chromatiales	135613|Chromatiales	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_216880_1	247490.KSU1_C1305	2.24e-92	288.0	COG0296@1|root,COG0296@2|Bacteria,2IXS1@203682|Planctomycetes	203682|Planctomycetes	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_1798459_2	227086.JGI_V11_54110	1.03e-32	125.0	COG2230@1|root,2QQW3@2759|Eukaryota	2759|Eukaryota	M	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	CMAS
k59_568762_1	506534.Rhein_2914	7.81e-101	303.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1WWWF@135613|Chromatiales	135613|Chromatiales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_451581_1	1304865.JAGF01000001_gene3175	4.83e-15	74.3	COG0223@1|root,COG0223@2|Bacteria,2GKH5@201174|Actinobacteria,4F0YA@85016|Cellulomonadaceae	201174|Actinobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_451581_2	1095767.CAHD01000208_gene129	1.28e-99	307.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,2GM21@201174|Actinobacteria,4F0N1@85016|Cellulomonadaceae	201174|Actinobacteria	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	fmu	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
k59_627549_1	329726.AM1_6037	2.04e-23	99.4	COG3547@1|root,COG3547@2|Bacteria,1G1N1@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase is116 is110 is902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1685348_1	1049564.TevJSym_bh00230	1.43e-52	171.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,1RRP3@1236|Gammaproteobacteria,1J5UD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_1685348_2	1249627.D779_0074	3.76e-35	124.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,1WVVY@135613|Chromatiales	135613|Chromatiales	E	imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
k59_569979_1	1415780.JPOG01000001_gene2281	9.06e-13	68.6	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1X3EN@135614|Xanthomonadales	135614|Xanthomonadales	O	Belongs to the peptidase S1C family	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
k59_569979_2	1123393.KB891316_gene2020	1.72e-17	78.6	2AY99@1|root,31QBJ@2|Bacteria,1RI92@1224|Proteobacteria,2VSPH@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_797817_1	1449351.RISW2_10800	5.71e-82	259.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,4KKKQ@93682|Roseivivax	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_797817_2	101852.XP_008083198.1	0.00018	45.1	COG0318@1|root,KOG1176@2759|Eukaryota,38D90@33154|Opisthokonta,3NWZC@4751|Fungi,3QR0I@4890|Ascomycota,20ZV2@147548|Leotiomycetes	4751|Fungi	I	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_1391545_1	1104324.P186_0587	4.86e-14	71.2	COG0778@1|root,arCOG00288@2157|Archaea,2XQMS@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_1391545_2	243233.MCA2737	5.86e-36	125.0	2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SHAU@1236|Gammaproteobacteria,1XFBV@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_797824_1	446466.Cfla_1934	8.2e-78	251.0	COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria,4F0S9@85016|Cellulomonadaceae	201174|Actinobacteria	G	Belongs to the transketolase family	tkt	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_1625570_1	160492.XF_2328	6.77e-47	165.0	COG1668@1|root,COG1668@2|Bacteria,1R3RG@1224|Proteobacteria,1RQT1@1236|Gammaproteobacteria,1X3GM@135614|Xanthomonadales	135614|Xanthomonadales	CP	permease	natB	-	-	ko:K09696	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.115	-	-	ABC2_membrane_2,ABC2_membrane_3
k59_746820_1	1123386.AUIW01000014_gene479	1.02e-57	194.0	COG1060@1|root,COG1060@2|Bacteria,1WIMY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate	mqnE	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
k59_863723_1	1121405.dsmv_1320	1.62e-74	248.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MIZ3@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_159854_1	1123377.AUIV01000027_gene829	8.63e-83	251.0	COG4555@1|root,COG4555@2|Bacteria,1QU2T@1224|Proteobacteria,1RY2V@1236|Gammaproteobacteria,1X307@135614|Xanthomonadales	135614|Xanthomonadales	CP	abc transporter atp-binding protein	-	-	3.6.3.7	ko:K09697	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.115	-	-	ABC_tran
k59_1686737_1	1049564.TevJSym_bt00150	2.31e-54	178.0	COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,1S0KH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	O-Methyltransferase	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_1391561_2	498211.CJA_2566	1.37e-41	146.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,1RYD7@1236|Gammaproteobacteria,1FG1K@10|Cellvibrio	1236|Gammaproteobacteria	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
k59_1567351_1	768671.ThimaDRAFT_2148	1.3e-62	195.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,1WWV2@135613|Chromatiales	135613|Chromatiales	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
k59_1567351_2	765912.Thimo_0729	1.24e-53	179.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1WWER@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
k59_1283502_2	686340.Metal_1309	1.92e-71	232.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1XE02@135618|Methylococcales	135618|Methylococcales	M	TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_1625598_1	290318.Cvib_0380	4.83e-42	155.0	COG2989@1|root,COG2989@2|Bacteria,1FEJK@1090|Chlorobi	1090|Chlorobi	S	PFAM Peptidoglycan-binding domain 1 protein	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_1517697_1	1120953.AUBH01000002_gene1490	5.14e-86	280.0	COG5549@1|root,COG5549@2|Bacteria,1QVUS@1224|Proteobacteria,1RN8A@1236|Gammaproteobacteria,469WV@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117
k59_336168_1	684949.ATTJ01000001_gene2229	2.49e-07	52.0	COG0411@1|root,COG0411@2|Bacteria,1WJG8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_336168_2	1125863.JAFN01000001_gene3440	3.69e-51	169.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M9C@68525|delta/epsilon subdivisions,2WJ75@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_1283515_1	911045.PSE_3737	1.59e-37	147.0	COG1289@1|root,COG1289@2|Bacteria	2|Bacteria	S	transmembrane transporter activity	VPA1578	-	-	-	-	-	-	-	-	-	-	-	FUSC
k59_746850_1	367299.JOEE01000001_gene1979	1.44e-109	317.0	COG0634@1|root,COG0634@2|Bacteria,2GMDZ@201174|Actinobacteria,4FESD@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_1035834_3	591158.SSMG_08295	1.65e-39	154.0	COG0270@1|root,COG0270@2|Bacteria,2GJS2@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family	-	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
k59_570018_1	765910.MARPU_01850	2.28e-35	128.0	COG1011@1|root,COG1011@2|Bacteria,1NH15@1224|Proteobacteria,1RP27@1236|Gammaproteobacteria,1WW6W@135613|Chromatiales	135613|Chromatiales	E	subfamily IA, variant 3	-	-	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD,HAD_2,Hydrolase
k59_570018_2	265072.Mfla_2600	1.3e-25	98.6	2A8M8@1|root,30XPN@2|Bacteria,1PJIW@1224|Proteobacteria,2W80P@28216|Betaproteobacteria,2KN7S@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1035835_1	572477.Alvin_3075	7.51e-115	348.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1WXBH@135613|Chromatiales	135613|Chromatiales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_336178_1	177437.HRM2_18950	4.19e-124	358.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,2MI6N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	qrcC	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
k59_628966_1	439235.Dalk_0006	8.48e-43	160.0	COG2202@1|root,COG4191@1|root,COG5000@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,42PKS@68525|delta/epsilon subdivisions,2WJBK@28221|Deltaproteobacteria,2MHTB@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
k59_1451829_1	404589.Anae109_3527	7.31e-30	120.0	COG1360@1|root,COG1360@2|Bacteria	2|Bacteria	N	Flagellar Motor Protein	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	OmpA
k59_1391614_1	751994.AGIG01000028_gene1918	1e-77	240.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1J4Q3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iSSON_1240.SSON_3886,iYL1228.KPN_04138	ATP-synt
k59_175365_1	465515.Mlut_18610	1.63e-29	115.0	COG0150@1|root,COG0150@2|Bacteria,2GJNY@201174|Actinobacteria,1W7UB@1268|Micrococcaceae	201174|Actinobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_175365_2	1304865.JAGF01000001_gene933	8.97e-80	251.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4F0I7@85016|Cellulomonadaceae	201174|Actinobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0008150,GO:0040007	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
k59_466586_2	880070.Cycma_2656	4.24e-18	89.0	COG1119@1|root,COG1119@2|Bacteria,4NEWY@976|Bacteroidetes,47K9D@768503|Cytophagia	976|Bacteroidetes	P	ABC-type molybdenum transport system ATPase component photorepair protein PhrA	modF	-	-	ko:K05776	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	-	-	-	ABC_tran
k59_1757627_1	1032480.MLP_31930	5.45e-145	442.0	COG1190@1|root,COG2898@1|root,COG1190@2|Bacteria,COG2898@2|Bacteria,2GKE0@201174|Actinobacteria,4DQ4F@85009|Propionibacteriales	201174|Actinobacteria	J	Uncharacterised conserved protein (DUF2156)	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DUF2156,tRNA-synt_2,tRNA-synt_2_TM,tRNA_anti-codon
k59_762451_1	439235.Dalk_3266	3.13e-55	194.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_1054939_1	203122.Sde_0065	9.82e-15	73.2	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,46541@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG1055 Na H antiporter NhaD and related arsenite permeases	nhaD	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_641889_2	1502851.FG93_05369	2.45e-16	77.4	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2TQQ1@28211|Alphaproteobacteria,3JSIG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
k59_1812731_1	1235457.C404_09650	1.63e-25	107.0	COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,2VQEZ@28216|Betaproteobacteria,1K2A9@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1812731_2	713586.KB900536_gene146	4.64e-130	380.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,1WWET@135613|Chromatiales	135613|Chromatiales	E	PFAM Aminotransferase class I and II	-	-	2.6.1.17	ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1406530_1	629773.AORY01000004_gene442	1.47e-30	119.0	COG3509@1|root,COG3509@2|Bacteria,1R1R8@1224|Proteobacteria,2U1WD@28211|Alphaproteobacteria,2K0S3@204457|Sphingomonadales	204457|Sphingomonadales	Q	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
k59_350485_1	635013.TherJR_2223	9.93e-37	142.0	COG1470@1|root,COG5276@1|root,COG1470@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	Big_5,CarboxypepD_reg,DUF1566,He_PIG,LVIVD,SLH
k59_1166863_1	670292.JH26_16510	2.51e-72	226.0	COG1028@1|root,COG1028@2|Bacteria,1RAEZ@1224|Proteobacteria,2U7DM@28211|Alphaproteobacteria,1JT55@119045|Methylobacteriaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	csgA	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_702241_1	644284.Arch_0148	7.86e-18	89.4	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,2GIT4@201174|Actinobacteria,4D3U9@85005|Actinomycetales	201174|Actinobacteria	CP	Domain related to MnhB subunit of Na+/H+ antiporter	mrpA/mrpB	-	-	ko:K05565,ko:K14086	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
k59_1166866_1	1454004.AW11_00972	1.53e-50	182.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,1KQ8R@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1757668_1	1267005.KB911259_gene4062	4.12e-92	283.0	COG0304@1|root,COG0304@2|Bacteria,1MXZ7@1224|Proteobacteria,2TVEB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	synthase	fabF2	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ketoacyl-synt
k59_809528_1	522306.CAP2UW1_2293	3.03e-58	191.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VHPC@28216|Betaproteobacteria,1KR31@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4,TAT_signal
k59_1054988_1	1379270.AUXF01000003_gene3500	1.19e-32	127.0	COG4108@1|root,COG4108@2|Bacteria,1ZSMR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,RF3_C
k59_1812769_1	314278.NB231_00750	4.44e-46	164.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria,1WWCF@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3329,HATPase_c,HisKA,PAS,PAS_8
k59_1166887_1	472759.Nhal_1240	4.01e-77	239.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria,1WXJX@135613|Chromatiales	135613|Chromatiales	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
k59_1232209_1	706439.HMPREF9057_03173	4.64e-85	259.0	COG4221@1|root,COG4221@2|Bacteria,2GMGQ@201174|Actinobacteria,4D3H2@85005|Actinomycetales	201174|Actinobacteria	S	Oxidoreductase, short chain dehydrogenase reductase family protein	sdh	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1757693_1	335543.Sfum_0294	1.93e-23	104.0	COG0591@1|root,COG1842@1|root,COG3852@1|root,COG0591@2|Bacteria,COG1842@2|Bacteria,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,43CEX@68525|delta/epsilon subdivisions,2X7PW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HisKA,PAS
k59_762521_1	471853.Bcav_2905	2.16e-82	253.0	COG3396@1|root,COG3396@2|Bacteria,2GKXZ@201174|Actinobacteria	201174|Actinobacteria	S	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like	-	-	-	-	-	-	-	-	-	-	-	-	MiaE_2
k59_1702453_1	631362.Thi970DRAFT_00111	1.27e-62	206.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria,1WWQN@135613|Chromatiales	135613|Chromatiales	H	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
k59_1232235_1	1216976.AX27061_3878	3.81e-82	251.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VHYN@28216|Betaproteobacteria,3T3A0@506|Alcaligenaceae	28216|Betaproteobacteria	E	ABC-type branched-chain amino acid transport systems ATPase component	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_809559_1	1207076.ALAT01000099_gene2432	1.18e-95	299.0	COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,1RNJ3@1236|Gammaproteobacteria,1Z28Q@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	M	COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_641958_1	518766.Rmar_2223	1.44e-51	172.0	COG0861@1|root,COG0861@2|Bacteria,4NFFD@976|Bacteroidetes,1FIQZ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Integral membrane protein TerC family	-	-	-	-	-	-	-	-	-	-	-	-	TerC
k59_1055050_1	751994.AGIG01000035_gene357	5.88e-108	329.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1J7VQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	5'-nucleotidase, C-terminal domain	soxB	-	-	ko:K17224	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	5_nucleotid_C
k59_1406573_1	498211.CJA_3396	3.02e-67	225.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1FGJ1@10|Cellvibrio	1236|Gammaproteobacteria	L	it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction	rep	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022402,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044786,GO:0044787,GO:0046483,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K03656,ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1406573_2	631362.Thi970DRAFT_04271	3.46e-82	261.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1WWMF@135613|Chromatiales	135613|Chromatiales	O	PFAM Magnesium chelatase, ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_1166935_1	56107.Cylst_6163	5.13e-97	298.0	COG1032@1|root,COG1032@2|Bacteria,1G01Y@1117|Cyanobacteria,1HMJH@1161|Nostocales	1117|Cyanobacteria	C	PFAM Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
k59_233269_1	1033802.SSPSH_002850	1.54e-28	115.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	PFAM von Willebrand factor type A	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA
k59_233269_2	292415.Tbd_2158	1.35e-80	249.0	COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,2VN8Q@28216|Betaproteobacteria,1KS9T@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Mut7-C ubiquitin	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
k59_582823_1	509191.AEDB02000067_gene825	1.56e-34	135.0	COG1022@1|root,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,25E9H@186801|Clostridia,3WI3M@541000|Ruminococcaceae	186801|Clostridia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_809573_1	796620.VIBC2010_08558	1.72e-57	193.0	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,1RP4P@1236|Gammaproteobacteria,1XSW6@135623|Vibrionales	135623|Vibrionales	S	NAD FAD-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_1812855_1	717773.Thicy_0726	2.5e-51	171.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,1RPII@1236|Gammaproteobacteria,46091@72273|Thiotrichales	72273|Thiotrichales	S	PFAM Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_175499_1	1123368.AUIS01000008_gene2246	3.81e-62	214.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Acyl-CoA synthetase (NDP forming)	yfiQ	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006475,GO:0006807,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0022607,GO:0032459,GO:0032462,GO:0034212,GO:0036211,GO:0043170,GO:0043254,GO:0043412,GO:0043543,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0052858,GO:0061733,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:1901564	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_762573_1	392499.Swit_1066	3.65e-41	154.0	COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2U1C8@28211|Alphaproteobacteria,2K263@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_1406594_2	1500894.JQNN01000001_gene939	1.06e-24	103.0	COG4972@1|root,COG4972@2|Bacteria,1N0HS@1224|Proteobacteria,2VQYY@28216|Betaproteobacteria,473FM@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	Pilus assembly protein	-	-	-	ko:K12279	-	-	-	-	ko00000,ko02044	-	-	-	PilM_2
k59_1055115_1	870187.Thini_3829	9.4e-08	58.9	COG2885@1|root,COG2885@2|Bacteria,1P1AB@1224|Proteobacteria,1RMCQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the ompA family	oprF	-	-	-	-	-	-	-	-	-	-	-	OmpA
k59_522899_1	396588.Tgr7_0799	2.44e-158	458.0	COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,1WXAG@135613|Chromatiales	135613|Chromatiales	E	PFAM sodium alanine symporter	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_522899_2	1114970.PSF113_0543	5.37e-44	150.0	COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,1S60F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Aspartyl protease	orf	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
k59_582848_1	471853.Bcav_0002	3.49e-126	370.0	COG0592@1|root,COG0592@2|Bacteria,2GJK3@201174|Actinobacteria	201174|Actinobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_582848_2	446469.Sked_00040	1.96e-16	78.2	COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria	201174|Actinobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
k59_762590_1	996637.SGM_6239	2.34e-53	189.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,2GJ11@201174|Actinobacteria	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
k59_1757764_1	314285.KT71_07794	2.37e-73	235.0	COG1473@1|root,COG1473@2|Bacteria,1MX6N@1224|Proteobacteria,1SMAR@1236|Gammaproteobacteria,1J84W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer
k59_1812897_1	754476.Q7A_1269	4.6e-94	289.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,45ZY4@72273|Thiotrichales	72273|Thiotrichales	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_466801_1	1049564.TevJSym_by00030	1.35e-151	451.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1J4T4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iECOK1_1307.ECOK1_0652,iECS88_1305.ECS88_0684,iNRG857_1313.NRG857_02925,iPC815.YPO2610	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1465863_1	439235.Dalk_3322	2.7e-67	218.0	COG0438@1|root,COG0438@2|Bacteria,1N9EV@1224|Proteobacteria,42PK2@68525|delta/epsilon subdivisions,2WJS7@28221|Deltaproteobacteria,2MIWA@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_643873_2	1218173.BALCAV_0205085	7.51e-22	89.0	COG0203@1|root,COG0203@2|Bacteria,1V6JQ@1239|Firmicutes,4HGX2@91061|Bacilli,1ZG80@1386|Bacillus	91061|Bacilli	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
k59_704172_1	367299.JOEE01000002_gene2329	1.32e-75	241.0	COG0642@1|root,COG2205@2|Bacteria,2GIV9@201174|Actinobacteria,4FF2V@85021|Intrasporangiaceae	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_469546_1	765912.Thimo_1803	2.23e-57	187.0	COG1363@1|root,COG1363@2|Bacteria,1MXEU@1224|Proteobacteria,1RSHP@1236|Gammaproteobacteria,1WWZP@135613|Chromatiales	135613|Chromatiales	G	peptidase M42	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
k59_469546_2	631362.Thi970DRAFT_00640	9.8e-69	224.0	COG0189@1|root,COG0454@1|root,COG0189@2|Bacteria,COG0456@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria,1WWH7@135613|Chromatiales	135613|Chromatiales	HJ	ATP-grasp	-	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,RimK
k59_704193_2	366602.Caul_4355	1.28e-46	159.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2U2QE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3547 Transposase and inactivated derivatives	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_643912_2	696369.KI912183_gene1130	8.17e-16	79.7	COG1150@1|root,COG1150@2|Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	-	-	1.17.1.9	ko:K00125,ko:K03646	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000,ko02000	2.C.1.2	-	-	Fer4,Fer4_17,Fer4_8,FrhB_FdhB_C
k59_1641893_2	367299.JOEE01000001_gene1516	6.53e-93	286.0	COG0402@1|root,COG0402@2|Bacteria,2GM63@201174|Actinobacteria,4FF0Y@85021|Intrasporangiaceae	201174|Actinobacteria	F	Amidohydrolase family	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_704200_1	1249627.D779_3757	3.46e-91	289.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1WW51@135613|Chromatiales	135613|Chromatiales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_811181_1	670307.HYPDE_35843	4.93e-10	67.4	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,3N70G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
k59_704201_1	1267005.KB911255_gene2424	2.13e-97	288.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,2TT3P@28211|Alphaproteobacteria,3N6WY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Phosphate acyltransferases	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_1169721_1	35754.JNYJ01000009_gene1822	6.95e-94	290.0	COG2160@1|root,COG2160@2|Bacteria,2GJNB@201174|Actinobacteria,4DAIF@85008|Micromonosporales	201174|Actinobacteria	G	Catalyzes the conversion of L-arabinose to L-ribulose	araA	-	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	-	Arabinose_Iso_C,Arabinose_Isome
k59_524872_1	1068980.ARVW01000001_gene5379	8.46e-23	98.6	COG0697@1|root,COG0697@2|Bacteria,2I8X5@201174|Actinobacteria	201174|Actinobacteria	EG	of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_811198_1	572477.Alvin_0350	1.74e-82	254.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria,1WVXU@135613|Chromatiales	135613|Chromatiales	H	Belongs to the NadC ModD family	-	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
k59_469627_1	1267005.KB911255_gene2897	2.18e-88	278.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,3N7Z7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Extracellular solute-binding protein	yejA	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
k59_469629_1	746697.Aeqsu_1607	5.55e-17	80.1	2DBMF@1|root,2Z9YG@2|Bacteria,4NPWU@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1467584_1	983920.Y88_0359	2.16e-68	222.0	COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2TSHG@28211|Alphaproteobacteria,2K1R5@204457|Sphingomonadales	204457|Sphingomonadales	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
k59_469636_1	1026882.MAMP_00831	3.57e-14	75.9	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1S2IK@1236|Gammaproteobacteria,463P1@72273|Thiotrichales	72273|Thiotrichales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_1815686_1	96561.Dole_0222	2.44e-72	231.0	COG0057@1|root,COG0057@2|Bacteria,1R8ZT@1224|Proteobacteria,42PY6@68525|delta/epsilon subdivisions,2WKEI@28221|Deltaproteobacteria,2MII4@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_811229_1	979556.MTES_0621	1.5e-61	204.0	COG3845@1|root,COG3845@2|Bacteria,2H7KJ@201174|Actinobacteria,4FKR5@85023|Microbacteriaceae	201174|Actinobacteria	S	ATPases associated with a variety of cellular activities	yufO	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
k59_524925_1	402881.Plav_2276	6.71e-48	169.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2TT32@28211|Alphaproteobacteria,1JNAF@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_1815699_1	590998.Celf_2349	1.46e-85	261.0	COG1385@1|root,COG1385@2|Bacteria,2GTKX@201174|Actinobacteria,4F0KK@85016|Cellulomonadaceae	201174|Actinobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
k59_524932_2	446469.Sked_08550	1.67e-70	216.0	COG0041@1|root,COG0041@2|Bacteria,2IFFD@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	GO:0008150,GO:0040007	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3275c	AIRC
k59_1641964_1	713586.KB900536_gene1465	2.88e-107	330.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1WVYF@135613|Chromatiales	135613|Chromatiales	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_644002_1	1122137.AQXF01000007_gene3526	1.27e-29	109.0	COG2142@1|root,COG2142@2|Bacteria,1MZND@1224|Proteobacteria,2UC3G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	succinate dehydrogenase	sdhD	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_644002_2	582899.Hden_3240	1.37e-26	101.0	COG2009@1|root,COG2009@2|Bacteria,1N02N@1224|Proteobacteria,2UC47@28211|Alphaproteobacteria,3N7AM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	succinate dehydrogenase	sdhC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_1759635_1	1146883.BLASA_1772	5.96e-48	177.0	COG4974@1|root,COG4974@2|Bacteria,2I56I@201174|Actinobacteria,4ERUD@85013|Frankiales	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1169839_1	335543.Sfum_1970	1.54e-130	376.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,42MVW@68525|delta/epsilon subdivisions,2WKKC@28221|Deltaproteobacteria,2MQGV@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Oxidoreductase NAD-binding domain	hdrF	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
k59_1584881_1	367299.JOEE01000002_gene2624	6.41e-101	317.0	COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,4FFGX@85021|Intrasporangiaceae	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0008094,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034335,GO:0042623,GO:0061505,GO:0140097	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1641989_1	1121405.dsmv_2479	3.44e-43	154.0	COG3659@1|root,COG3659@2|Bacteria,1Q0I4@1224|Proteobacteria,42WBJ@68525|delta/epsilon subdivisions,2WS5J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Carbohydrate-selective porin OprB	-	-	-	-	-	-	-	-	-	-	-	-	OprB
k59_1641995_1	1333856.L686_07080	6.66e-23	97.1	COG0010@1|root,COG0010@2|Bacteria,1NCRN@1224|Proteobacteria,1RNKI@1236|Gammaproteobacteria,1Z3P6@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	E	Arginase family	hutG	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016813,GO:0019439,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0052803,GO:0052805,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.5.3.11,3.5.3.8	ko:K01479,ko:K01480	ko00330,ko00340,ko01100,map00330,map00340,map01100	M00045,M00133	R01157,R02285	RC00024,RC00221,RC00329,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
k59_1641995_2	1120953.AUBH01000002_gene1407	4.7e-19	87.8	COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,1RMI9@1236|Gammaproteobacteria,464FR@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	COG1228 Imidazolonepropionase and related amidohydrolases	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
k59_125138_1	1049564.TevJSym_ac01060	1.64e-67	221.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,1J895@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Starch synthase catalytic domain	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_1181904_1	1304865.JAGF01000001_gene923	8.85e-70	220.0	COG1087@1|root,COG1087@2|Bacteria,2GMCW@201174|Actinobacteria,4F0IT@85016|Cellulomonadaceae	201174|Actinobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE1	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_12125_1	880072.Desac_1463	8.38e-47	172.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2MR0B@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1066042_2	1068980.ARVW01000001_gene4419	1.65e-14	69.7	COG0346@1|root,COG0346@2|Bacteria,2IFKS@201174|Actinobacteria,4E5EV@85010|Pseudonocardiales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
k59_418345_1	1209984.BN978_04814	7.92e-25	108.0	COG3299@1|root,COG3299@2|Bacteria	2|Bacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
k59_1181907_1	439235.Dalk_3373	3.75e-66	219.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,42N1H@68525|delta/epsilon subdivisions,2WJ0R@28221|Deltaproteobacteria,2MHVX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1066044_1	930169.B5T_01411	3.67e-08	53.9	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,1XHWW@135619|Oceanospirillales	135619|Oceanospirillales	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_1830998_1	446471.Xcel_0483	3.93e-95	288.0	COG0142@1|root,COG0142@2|Bacteria,2GMB4@201174|Actinobacteria,4F3UX@85017|Promicromonosporaceae	201174|Actinobacteria	H	Polyprenyl synthetase	hepT	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_1476696_2	420324.KI911934_gene211	6.35e-75	235.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2TRN4@28211|Alphaproteobacteria,1JRT7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	TIGRFAM glycine cleavage system T protein	gcvT	GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_1709767_1	472759.Nhal_0221	7.67e-86	265.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1WXP3@135613|Chromatiales	135613|Chromatiales	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_1592069_1	1089546.AQUI01000002_gene4395	7.83e-05	50.1	COG0839@1|root,COG0839@2|Bacteria,2GKRS@201174|Actinobacteria,40A2S@622450|Actinopolysporales	201174|Actinobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_1241684_1	1304872.JAGC01000005_gene2164	1.74e-17	80.9	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,42M7N@68525|delta/epsilon subdivisions,2WM4F@28221|Deltaproteobacteria,2MAN1@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.10.3.10,1.9.3.1	ko:K02275,ko:K02297	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081,R11335	RC00016,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX2,COX2_TM,COX_ARM,Cytochrom_C,Cytochrome_CBB3
k59_1768173_1	1304865.JAGF01000001_gene3213	3.56e-95	302.0	COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,4F10T@85016|Cellulomonadaceae	201174|Actinobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_12160_1	754436.JCM19237_2331	1.14e-07	53.1	COG2223@1|root,COG2223@2|Bacteria,1MW71@1224|Proteobacteria,1RN10@1236|Gammaproteobacteria,1XSI0@135623|Vibrionales	135623|Vibrionales	P	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1709777_1	401526.TcarDRAFT_1679	4.82e-127	379.0	COG1055@1|root,COG1055@2|Bacteria,1TRZC@1239|Firmicutes,4H2X6@909932|Negativicutes	909932|Negativicutes	P	Dicarboxylate carrier	-	-	-	-	-	-	-	-	-	-	-	-	MatC_N
k59_245877_1	870967.VIS19158_09149	4.42e-08	57.8	COG3464@1|root,COG3464@2|Bacteria,1N2V1@1224|Proteobacteria,1RN1I@1236|Gammaproteobacteria,1XWEU@135623|Vibrionales	135623|Vibrionales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3
k59_245877_2	351160.RCIX171	5.62e-06	49.3	COG3464@1|root,arCOG04913@2157|Archaea,2Y0Z8@28890|Euryarchaeota,2NB64@224756|Methanomicrobia	224756|Methanomicrobia	L	zinc-finger of transposase IS204/IS1001/IS1096/IS1165	-	-	-	ko:K07485	-	-	-	-	ko00000	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_653503_1	933262.AXAM01000005_gene2490	4.7e-26	108.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria,2MHZP@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	Signal transducing histidine kinase, homodimeric	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
k59_653503_2	933262.AXAM01000005_gene2489	2.82e-23	97.1	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42MR2@68525|delta/epsilon subdivisions,2WKKH@28221|Deltaproteobacteria,2MJG1@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N,Response_reg
k59_245879_1	879212.DespoDRAFT_01337	2.47e-106	319.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,42MXS@68525|delta/epsilon subdivisions,2WKEK@28221|Deltaproteobacteria,2MI5R@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Seven times multi-haem cytochrome CxxCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Multi-haem_cyto
k59_477220_2	765910.MARPU_14225	3.32e-111	332.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1WWYB@135613|Chromatiales	135613|Chromatiales	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_477220_3	323848.Nmul_A2492	1.14e-17	82.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2VI7I@28216|Betaproteobacteria,3725K@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
k59_363477_1	1120959.ATXF01000008_gene614	1.65e-49	181.0	COG1483@1|root,COG1483@2|Bacteria,2GMTG@201174|Actinobacteria	201174|Actinobacteria	S	ATPase (AAA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1831023_2	1042375.AFPL01000056_gene2362	8.53e-24	97.4	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,1S22I@1236|Gammaproteobacteria,466DR@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	GO:0003674,GO:0003824,GO:0004416,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
k59_1476731_1	335543.Sfum_0080	2.41e-101	306.0	COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,42MN2@68525|delta/epsilon subdivisions,2WIMJ@28221|Deltaproteobacteria,2MR8K@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pfam:DUF162	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
k59_1533670_1	314287.GB2207_07552	3.23e-134	400.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,1RM95@1236|Gammaproteobacteria,1J4GW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_1302888_1	335543.Sfum_3687	1.62e-90	275.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42RCI@68525|delta/epsilon subdivisions,2WM55@28221|Deltaproteobacteria,2MQDQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_1302892_1	225937.HP15_3687	2.48e-09	58.9	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,4649M@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_1302892_2	1121921.KB898706_gene3352	1.99e-39	138.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,2PN2U@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_653534_1	468059.AUHA01000002_gene563	5.54e-68	231.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IR3J@117747|Sphingobacteriia	976|Bacteroidetes	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,Guanylate_cyc,HTH_18,TPR_8
k59_1476761_1	1341151.ASZU01000003_gene2366	5e-09	62.8	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HB7D@91061|Bacilli,27BIZ@186824|Thermoactinomycetaceae	91061|Bacilli	O	Subtilase family	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	PPC,Peptidase_S8
k59_829424_1	1121382.JQKG01000005_gene3259	1.32e-112	345.0	COG0569@1|root,COG2985@1|root,COG0569@2|Bacteria,COG2985@2|Bacteria,1WM9F@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Predicted Permease Membrane Region	-	-	-	-	-	-	-	-	-	-	-	-	Asp-Al_Ex,TrkA_C
k59_125201_1	928724.SacglDRAFT_02261	1.58e-60	198.0	COG2267@1|root,COG2267@2|Bacteria,2IFK6@201174|Actinobacteria,4E52V@85010|Pseudonocardiales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_301218_1	1240349.ANGC01000051_gene4108	4.84e-51	171.0	COG2135@1|root,COG2135@2|Bacteria,2GKY8@201174|Actinobacteria,4FUQR@85025|Nocardiaceae	201174|Actinobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
k59_12247_1	1049564.TevJSym_aj00510	2.69e-59	199.0	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,1J6D6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Citrate transporter	nhaD	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_477259_1	543632.JOJL01000024_gene2042	2.92e-17	79.7	COG0309@1|root,COG0309@2|Bacteria,2GJ7N@201174|Actinobacteria,4DHG8@85008|Micromonosporales	201174|Actinobacteria	O	AIR synthase related protein, C-terminal domain	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
k59_477259_2	543632.JOJL01000024_gene2043	1.15e-80	248.0	COG0409@1|root,COG0409@2|Bacteria,2GMHA@201174|Actinobacteria,4DGUE@85008|Micromonosporales	201174|Actinobacteria	O	Hydrogenase formation hypA family	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
k59_1121942_1	1265502.KB905946_gene1123	4.33e-106	338.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2VJ2F@28216|Betaproteobacteria,4A9MX@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narG	-	1.7.5.1	ko:K00370,ko:K17050	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
k59_70041_1	471853.Bcav_2926	1.34e-82	258.0	COG5542@1|root,COG5542@2|Bacteria,2GJQF@201174|Actinobacteria	201174|Actinobacteria	NT	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2,PMT_2
k59_12256_1	439235.Dalk_4002	7.38e-114	337.0	COG0232@1|root,COG0232@2|Bacteria,1R6QQ@1224|Proteobacteria,42M0H@68525|delta/epsilon subdivisions,2WJ33@28221|Deltaproteobacteria,2MHN1@213118|Desulfobacterales	28221|Deltaproteobacteria	F	SMART metal-dependent phosphohydrolase HD region	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_1831065_1	1123392.AQWL01000002_gene1774	2.28e-186	543.0	COG0348@1|root,COG3901@1|root,COG0348@2|Bacteria,COG3901@2|Bacteria,1MY5M@1224|Proteobacteria,2VH7V@28216|Betaproteobacteria	28216|Betaproteobacteria	CK	FMN-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind,Fer4_10,Fer4_5
k59_1831065_2	1049564.TevJSym_bg00250	1.9e-25	104.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,1J4NX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	von Willebrand factor (vWF) type A domain	norD	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_2
k59_70045_1	1232410.KI421425_gene1553	1.09e-106	334.0	COG4932@1|root,COG4932@2|Bacteria,1QZFW@1224|Proteobacteria	1224|Proteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
k59_12259_1	103733.JNYO01000020_gene1908	6.39e-10	59.3	COG1231@1|root,COG1231@2|Bacteria,2GMV0@201174|Actinobacteria,4DZ53@85010|Pseudonocardiales	201174|Actinobacteria	E	Flavin containing amine oxidoreductase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_12259_2	1179773.BN6_59250	7.82e-29	115.0	COG1231@1|root,COG1231@2|Bacteria,2GMV0@201174|Actinobacteria,4DZ53@85010|Pseudonocardiales	201174|Actinobacteria	E	Flavin containing amine oxidoreductase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_1533704_1	768671.ThimaDRAFT_2144	2.16e-109	344.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1066178_1	1386089.N865_06725	4.59e-132	385.0	COG0604@1|root,COG0604@2|Bacteria,2GKFF@201174|Actinobacteria,4FFKA@85021|Intrasporangiaceae	201174|Actinobacteria	C	NADPH quinone reductase	ccr	-	1.3.1.86	ko:K17829	ko00650,ko01120,ko01130,ko01200,map00650,map01120,map01130,map01200	-	R09738	RC00076	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1476783_1	1298863.AUEP01000011_gene650	1.01e-24	104.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria,4DTMA@85009|Propionibacteriales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
k59_1476783_2	1380354.JIAN01000005_gene1963	1.97e-22	93.6	COG2197@1|root,COG2197@2|Bacteria,2IFE7@201174|Actinobacteria	201174|Actinobacteria	KT	regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1181977_1	543913.D521_0999	6.97e-08	55.8	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2VPZV@28216|Betaproteobacteria,1KQ1Y@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
k59_1181977_2	452637.Oter_3554	1.52e-08	57.8	COG0134@1|root,COG0134@2|Bacteria,46TR6@74201|Verrucomicrobia,3K7YE@414999|Opitutae	414999|Opitutae	E	Belongs to the TrpC family	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
k59_1241779_1	756272.Plabr_4750	1.56e-236	671.0	COG3119@1|root,COG3119@2|Bacteria,2IX0Y@203682|Planctomycetes	203682|Planctomycetes	P	PFAM sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1476791_1	633149.Bresu_1433	3.4e-65	209.0	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2TU3I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	oxidase subunit	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
k59_1476791_2	1121124.JNIX01000009_gene2790	1.82e-10	62.8	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2TQMA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	oxidase subunit	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_1066194_1	522306.CAP2UW1_3911	6.28e-45	152.0	COG1143@1|root,COG1143@2|Bacteria,1QZJJ@1224|Proteobacteria,2WHVP@28216|Betaproteobacteria	28216|Betaproteobacteria	C	4Fe-4S binding domain	-	-	-	ko:K02572	-	-	-	-	ko00000	-	-	-	-
k59_653562_1	1232437.KL662020_gene690	5.24e-46	169.0	COG0204@1|root,COG1647@1|root,COG0204@2|Bacteria,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,42NBK@68525|delta/epsilon subdivisions,2WIUP@28221|Deltaproteobacteria,2MHMP@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Acyltransferase,Hydrolase_4
k59_1066200_1	1070319.CAGGBEG34_250048	7.28e-46	168.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,1JZZ1@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_70073_1	1215092.PA6_028_00580	3.45e-11	64.7	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RZ3B@1236|Gammaproteobacteria,1YDT6@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9
k59_70073_2	1027273.GZ77_15620	1.03e-37	132.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1XJ7K@135619|Oceanospirillales	135619|Oceanospirillales	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_363555_1	1221522.B723_21680	1.47e-47	159.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,1RMG1@1236|Gammaproteobacteria,1YP9W@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	Q	ABC transporter, ATP-binding protein	ybbA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_950793_1	880526.KE386488_gene1083	1.76e-97	296.0	COG0015@1|root,COG0015@2|Bacteria,4NFY8@976|Bacteroidetes,2FMYF@200643|Bacteroidia,22UZK@171550|Rikenellaceae	976|Bacteroidetes	F	Adenylosuccinate lyase C-terminal	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,ASL_C,Lyase_1
k59_653571_2	1713.JOFV01000001_gene1966	2.69e-24	98.6	COG1211@1|root,COG1211@2|Bacteria,2GNHP@201174|Actinobacteria,4F191@85016|Cellulomonadaceae	201174|Actinobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
k59_125245_1	384765.SIAM614_13748	2.79e-76	239.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	fbpC	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
k59_246035_1	105559.Nwat_0622	1.1e-61	196.0	COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,1RSM2@1236|Gammaproteobacteria,1WX5K@135613|Chromatiales	135613|Chromatiales	L	Belongs to the Nudix hydrolase family	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_1066230_1	1255043.TVNIR_1572	1.18e-140	426.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WW6D@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_1302981_1	1267005.KB911259_gene3839	6.05e-143	415.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2TQVM@28211|Alphaproteobacteria,3N7T4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Aminotransferase class I and II	dapL	-	2.6.1.17	ko:K14261,ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_653586_1	596151.DesfrDRAFT_2501	1.08e-107	326.0	COG1566@1|root,COG1566@2|Bacteria,1MWG0@1224|Proteobacteria,42NAT@68525|delta/epsilon subdivisions,2WPPB@28221|Deltaproteobacteria,2MBTW@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1417047_1	927658.AJUM01000010_gene1352	6.35e-24	107.0	COG0642@1|root,COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,4NDXU@976|Bacteroidetes,2FRUD@200643|Bacteroidia	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_9,Response_reg
k59_1303671_1	227882.SAV_3707	1.54e-17	81.3	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria	201174|Actinobacteria	E	dehydrogenase	adh	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
k59_951475_1	59538.XP_005977051.1	1.28e-13	69.3	COG0031@1|root,KOG1252@2759|Eukaryota,38B7H@33154|Opisthokonta,3BBJK@33208|Metazoa,3CY68@33213|Bilateria,488CX@7711|Chordata,48W7H@7742|Vertebrata,3J8K4@40674|Mammalia	33208|Metazoa	E	cysteine biosynthetic process from serine	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1477554_1	631454.N177_3957	3.54e-114	358.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria,1JMZX@119043|Rhodobiaceae	28211|Alphaproteobacteria	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_477802_1	1415779.JOMH01000001_gene183	6.72e-80	256.0	28MBM@1|root,2ZAQ2@2|Bacteria,1R5V6@1224|Proteobacteria,1S0K0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_477802_2	1906.SFRA_18065	2.11e-19	93.2	COG0515@1|root,COG0515@2|Bacteria,2IAZC@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_247062_1	1082931.KKY_3119	2.41e-82	264.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2TQNJ@28211|Alphaproteobacteria,3N67M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysC	-	2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU,GTP_EFTU_D2
k59_536632_1	1121405.dsmv_3100	2.94e-55	179.0	COG2974@1|root,COG2974@2|Bacteria,1RCUH@1224|Proteobacteria,42QVW@68525|delta/epsilon subdivisions,2WN5B@28221|Deltaproteobacteria,2MJPM@213118|Desulfobacterales	28221|Deltaproteobacteria	L	May be involved in recombination	-	-	-	-	-	-	-	-	-	-	-	-	RdgC
k59_595119_1	1517416.IDAT_07150	1.45e-39	142.0	COG0019@1|root,COG0019@2|Bacteria,1MW3T@1224|Proteobacteria,1RP8C@1236|Gammaproteobacteria,2QFJH@267893|Idiomarinaceae	1236|Gammaproteobacteria	H	Belongs to the Orn Lys Arg decarboxylase class-II family. NspC subfamily	nspC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019842,GO:0030170,GO:0034641,GO:0036094,GO:0042401,GO:0042710,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044010,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044764,GO:0045312,GO:0046204,GO:0046983,GO:0048037,GO:0050662,GO:0051704,GO:0070279,GO:0071704,GO:0097159,GO:0097164,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.1.1.96	ko:K13747	ko00330,ko01100,map00330,map01100	-	R09081,R09082	RC00299	ko00000,ko00001,ko01000	-	-	-	Orn_DAP_Arg_deC
k59_595119_2	314345.SPV1_09198	4.99e-56	185.0	COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria	1224|Proteobacteria	E	Saccharopine dehydrogenase	LYS1	-	1.5.1.43,1.5.1.7	ko:K00290,ko:K13746	ko00300,ko00310,ko00330,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map00330,map01100,map01110,map01130,map01230	M00030,M00032	R00715,R09079,R09080	RC00053,RC00217,RC00225,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0902	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_1592629_1	1173026.Glo7428_3055	3.08e-06	57.8	COG2931@1|root,COG2931@2|Bacteria,1G2GC@1117|Cyanobacteria	1117|Cyanobacteria	Q	FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,HemolysinCabind
k59_1422286_2	857087.Metme_1888	1.17e-48	172.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XDW6@135618|Methylococcales	135618|Methylococcales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1074012_1	935839.JAGJ01000018_gene2345	8.64e-99	306.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4F3YB@85017|Promicromonosporaceae	201174|Actinobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_77004_1	290340.AAur_3143	3.18e-35	147.0	COG1404@1|root,COG1404@2|Bacteria,2GJYH@201174|Actinobacteria,1W8B3@1268|Micrococcaceae	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	LGFP,Peptidase_S8,SLH,VCBS
k59_773808_1	338963.Pcar_0272	1.81e-140	412.0	COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,42PC9@68525|delta/epsilon subdivisions,2WKA4@28221|Deltaproteobacteria,43SZ4@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Na+ dependent nucleoside transporter C-terminus	-	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Gate,Nucleos_tra2_C,Nucleos_tra2_N
k59_1126311_1	459495.SPLC1_S100750	1.98e-87	278.0	COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,1G16R@1117|Cyanobacteria,1H85V@1150|Oscillatoriales	1117|Cyanobacteria	C	belongs to the CobB CobQ family	pta	-	2.3.1.8	ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,DRTGG,PTA_PTB
k59_1249025_1	243233.MCA2447	7.28e-90	291.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1XDRZ@135618|Methylococcales	135618|Methylococcales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_1422298_2	153948.NAL212_2601	9.5e-35	124.0	COG1943@1|root,COG1943@2|Bacteria,1QKQ2@1224|Proteobacteria,2WC8F@28216|Betaproteobacteria,374G1@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
k59_773811_1	1386089.N865_03090	1.76e-28	114.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
k59_1187344_1	593907.Celgi_0077	3.08e-94	285.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4F0IR@85016|Cellulomonadaceae	201174|Actinobacteria	E	PFAM aminotransferase class I and II	aspB	-	2.6.1.1,2.6.1.17,2.6.1.2,2.6.1.66	ko:K00812,ko:K14260,ko:K14267	ko00220,ko00250,ko00270,ko00290,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01130,map01210,map01230	M00016	R00258,R00355,R00694,R00734,R00896,R01215,R02433,R02619,R04475,R05052	RC00006,RC00008,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_130617_1	595494.Tola_0699	2.28e-69	214.0	COG2519@1|root,COG2519@2|Bacteria,1MXAK@1224|Proteobacteria,1RSIH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Methyl-transferase	yjhP	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
k59_130617_2	1047013.AQSP01000076_gene1473	1.18e-20	87.4	COG2020@1|root,COG2020@2|Bacteria,2NR07@2323|unclassified Bacteria	2|Bacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_1838210_1	396588.Tgr7_1069	5.32e-108	321.0	COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,1RN94@1236|Gammaproteobacteria,1WXKU@135613|Chromatiales	135613|Chromatiales	S	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
k59_899716_1	662479.C440_00390	2.16e-26	112.0	COG0855@1|root,arCOG04535@2157|Archaea,2XTCF@28890|Euryarchaeota,23TUG@183963|Halobacteria	183963|Halobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_958710_1	1209984.BN978_05384	5.44e-16	79.3	COG1680@1|root,COG1680@2|Bacteria,2GK3A@201174|Actinobacteria,23431@1762|Mycobacteriaceae	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_958710_2	1132836.RCCGE510_20779	6.45e-07	52.4	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_1839081_1	933262.AXAM01000004_gene2356	3.93e-72	243.0	COG0574@1|root,COG0745@1|root,COG0574@2|Bacteria,COG0745@2|Bacteria,1N38V@1224|Proteobacteria,42MWC@68525|delta/epsilon subdivisions,2WKAZ@28221|Deltaproteobacteria,2MICZ@213118|Desulfobacterales	28221|Deltaproteobacteria	GT	pyruvate phosphate dikinase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2,PPDK_N
k59_899717_2	1123511.KB905862_gene2352	1.05e-24	103.0	COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,4H2F8@909932|Negativicutes	909932|Negativicutes	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_958712_1	1267005.KB911257_gene936	1.4e-22	91.7	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2TRPD@28211|Alphaproteobacteria,3N9HQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Reversible hydration of carbon dioxide	cynT	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
k59_1249945_1	1267005.KB911257_gene1003	5.26e-84	255.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2TTFF@28211|Alphaproteobacteria,3N6P9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_1075245_1	1234595.C725_0753	1.04e-56	197.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,HemolysinCabind,Sulfatase
k59_482935_1	991905.SL003B_2384	3.36e-73	227.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,2TRY6@28211|Alphaproteobacteria,4BQ3T@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N,YjbR
k59_774344_1	591159.ACEZ01000002_gene6094	2.35e-32	123.0	COG0070@1|root,COG0070@2|Bacteria,2IB5W@201174|Actinobacteria	201174|Actinobacteria	E	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1539364_1	158500.BV97_01400	2.86e-32	127.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2U1EJ@28211|Alphaproteobacteria,2K06V@204457|Sphingomonadales	204457|Sphingomonadales	U	Type II secretory pathway, component ExeA	exeA	-	-	-	-	-	-	-	-	-	-	-	AAA_22
k59_899735_1	1041147.AUFB01000050_gene4052	1.9e-108	327.0	COG3385@1|root,COG3385@2|Bacteria,1PHKQ@1224|Proteobacteria,2VGVZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_1126883_1	96561.Dole_0187	5.9e-47	162.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,42NBV@68525|delta/epsilon subdivisions,2WK0F@28221|Deltaproteobacteria,2MI38@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
k59_255891_1	395493.BegalDRAFT_1138	4.28e-72	233.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,45ZXV@72273|Thiotrichales	72273|Thiotrichales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_1597721_1	471853.Bcav_1925	3.37e-87	266.0	COG0454@1|root,COG0456@2|Bacteria,2IGFQ@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_131275_1	580332.Slit_2292	1.2e-95	298.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria,44VA4@713636|Nitrosomonadales	28216|Betaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_131275_2	856793.MICA_1960	0.000734	43.1	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2UFRX@28211|Alphaproteobacteria,4BQZP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Hsp20/alpha crystallin family	hspC2	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_1773697_1	298654.FraEuI1c_0531	3.75e-85	265.0	COG1744@1|root,COG1744@2|Bacteria	2|Bacteria	ET	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp,TAT_signal
k59_1188008_1	765910.MARPU_01865	5.81e-21	93.6	COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,1QTS5@1224|Proteobacteria,1RMJS@1236|Gammaproteobacteria,1WW9Q@135613|Chromatiales	135613|Chromatiales	C	belongs to the CobB CobQ family	-	-	2.3.1.8	ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,DRTGG,PTA_PTB
k59_1188008_2	472759.Nhal_1152	4.85e-52	167.0	COG0071@1|root,COG0071@2|Bacteria,1NA27@1224|Proteobacteria,1S97S@1236|Gammaproteobacteria,1WYZX@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
k59_1188008_3	472759.Nhal_1151	1.42e-67	207.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S9S6@1236|Gammaproteobacteria,1WY94@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_77903_1	1205753.A989_00310	1.66e-23	104.0	COG0526@1|root,COG0526@2|Bacteria,1MWU8@1224|Proteobacteria,1SFUW@1236|Gammaproteobacteria,1X970@135614|Xanthomonadales	135614|Xanthomonadales	M	Protein of unknown function, DUF255	-	-	5.3.4.1	ko:K01829	-	-	-	-	ko00000,ko01000	-	-	-	Thioredoxin_7
k59_1075272_1	395493.BegalDRAFT_3230	2.49e-51	167.0	COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,460DN@72273|Thiotrichales	72273|Thiotrichales	L	Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis	rnt	-	-	ko:K03683	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_T
k59_1075272_2	62928.azo1279	8.37e-27	110.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2VI1Z@28216|Betaproteobacteria,2KWI8@206389|Rhodocyclales	206389|Rhodocyclales	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
k59_424163_1	1249627.D779_3712	9.68e-67	213.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,1WWXY@135613|Chromatiales	135613|Chromatiales	S	Permease YjgP YjgQ	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_958735_1	56780.SYN_02657	1.55e-65	210.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,42TG6@68525|delta/epsilon subdivisions,2WQ8T@28221|Deltaproteobacteria,2MRYG@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_482946_1	367299.JOEE01000001_gene2162	8.58e-102	325.0	COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria,4FFYE@85021|Intrasporangiaceae	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_22332_1	472759.Nhal_0765	2.02e-127	375.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1WVW0@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1773702_1	497321.C664_15598	4.82e-61	194.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,2VIWQ@28216|Betaproteobacteria,2KVP4@206389|Rhodocyclales	206389|Rhodocyclales	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
k59_189913_1	697282.Mettu_2218	3.31e-15	69.7	COG1531@1|root,COG1531@2|Bacteria,1N7PM@1224|Proteobacteria,1SRSR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	AJ	Protein of unknown function (DUF504)	-	-	-	-	-	-	-	-	-	-	-	-	DUF504
k59_189913_2	1122164.JHWF01000002_gene757	5.02e-43	146.0	COG1544@1|root,COG1544@2|Bacteria,1RJ55@1224|Proteobacteria,1S5AA@1236|Gammaproteobacteria,1JE6E@118969|Legionellales	118969|Legionellales	J	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
k59_189913_3	187272.Mlg_2213	8.98e-84	261.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the peptidase S1C family	degS	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0051788,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564	-	ko:K04691,ko:K04772	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
k59_1597732_2	477228.YO5_16168	1.6e-35	122.0	COG1734@1|root,COG1734@2|Bacteria,1MZIB@1224|Proteobacteria,1S8SP@1236|Gammaproteobacteria,1Z3A1@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	T	DnaK suppressor protein	ybiI	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
k59_1075291_1	768671.ThimaDRAFT_2628	5.9e-130	375.0	COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,1RSGA@1236|Gammaproteobacteria,1WW8S@135613|Chromatiales	135613|Chromatiales	S	PFAM conserved	-	-	-	ko:K02069	-	M00211	-	-	ko00000,ko00002,ko02000	9.B.25.1	-	-	UPF0014
k59_1075291_2	768671.ThimaDRAFT_2629	1.3e-20	88.2	COG4619@1|root,COG4619@2|Bacteria,1QTWV@1224|Proteobacteria,1S627@1236|Gammaproteobacteria,1WXSI@135613|Chromatiales	135613|Chromatiales	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_1310919_1	589865.DaAHT2_1923	2.54e-29	107.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,42UWR@68525|delta/epsilon subdivisions,2WQRB@28221|Deltaproteobacteria,2MP1G@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
k59_1310919_2	929558.SMGD1_1693	5.92e-11	66.2	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2YN0B@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	CP	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_1249983_1	292415.Tbd_0990	9.76e-137	397.0	COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,2VHI6@28216|Betaproteobacteria,1KRJA@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
k59_482955_1	631362.Thi970DRAFT_03690	1.2e-95	291.0	COG2863@1|root,COG2863@2|Bacteria,1R5BS@1224|Proteobacteria,1RYHW@1236|Gammaproteobacteria,1WWNB@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_CBB3
k59_958755_1	1049564.TevJSym_al00520	8.03e-40	144.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1J578@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	COG4591 ABC-type transport system, involved in lipoprotein release, permease component	lolC	GO:0005575,GO:0005623,GO:0005886,GO:0008104,GO:0008150,GO:0016020,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_1249990_1	1245469.S58_58890	2.27e-96	290.0	COG1633@1|root,COG1633@2|Bacteria,1N5FH@1224|Proteobacteria,2TU0E@28211|Alphaproteobacteria,3JWTC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	acsF	-	1.14.13.81	ko:K04035	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06265,R06266,R06267,R10068	RC00741,RC01491,RC01492,RC03042	ko00000,ko00001,ko01000	-	-	-	Rubrerythrin
k59_131300_1	472759.Nhal_1449	2.9e-78	253.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1WX4B@135613|Chromatiales	135613|Chromatiales	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_424182_1	28258.KP05_02865	1.92e-46	157.0	COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,1RNPQ@1236|Gammaproteobacteria,1XJQK@135619|Oceanospirillales	135619|Oceanospirillales	F	Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_774376_1	1121017.AUFG01000003_gene3425	1.09e-48	167.0	COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria,4FEXA@85021|Intrasporangiaceae	201174|Actinobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	GO:0008150,GO:0040007	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_22373_1	1089552.KI911559_gene1267	7.34e-06	47.8	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,2JPGU@204441|Rhodospirillales	204441|Rhodospirillales	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.96	ko:K16871	ko00250,ko00650,ko01100,ko01120,map00250,map00650,map01100,map01120	M00027	R10178	RC00008,RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_3
k59_22373_2	983917.RGE_34950	3.55e-47	162.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHEJ@28216|Betaproteobacteria,1KKFY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
k59_1485025_1	1283300.ATXB01000001_gene1437	6.01e-92	279.0	COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,1RP5A@1236|Gammaproteobacteria,1XF6C@135618|Methylococcales	135618|Methylococcales	P	Inositol monophosphatase family	-	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
k59_1188050_1	1169144.KB910944_gene2339	5.81e-19	92.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,4HA3G@91061|Bacilli,1ZSG3@1386|Bacillus	91061|Bacilli	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_4,PAS_9
k59_1597760_1	1370122.JHXQ01000010_gene1508	6.37e-16	79.7	COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,2TRPY@28211|Alphaproteobacteria,4B79Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Oligoendopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
k59_659627_2	337191.KTR9_2446	7.85e-21	95.9	COG0507@1|root,COG1112@1|root,COG1305@1|root,COG0507@2|Bacteria,COG1112@2|Bacteria,COG1305@2|Bacteria,2GKJW@201174|Actinobacteria,4GC98@85026|Gordoniaceae	201174|Actinobacteria	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DUF3320,DUF4011
k59_541767_1	1123371.ATXH01000028_gene21	6.04e-19	82.8	COG1100@1|root,COG1100@2|Bacteria,2GIDK@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Ras family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
k59_371543_1	543728.Vapar_1811	2.16e-06	53.9	COG3658@1|root,COG3658@2|Bacteria,1RB03@1224|Proteobacteria,2VUDN@28216|Betaproteobacteria,4AENH@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM cytochrome B561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_659628_1	765914.ThisiDRAFT_1142	9.31e-116	346.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1WWC9@135613|Chromatiales	135613|Chromatiales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_1126925_1	1122194.AUHU01000004_gene1489	2.93e-54	182.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,466CP@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
k59_371546_1	519989.ECTPHS_07102	1.31e-82	262.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1WW6G@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_774390_1	1123392.AQWL01000006_gene573	1.54e-32	115.0	COG0607@1|root,COG0607@2|Bacteria,1MZPW@1224|Proteobacteria,2VU52@28216|Betaproteobacteria,1KT5Y@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_774390_2	637389.Acaty_c0734	9.17e-12	65.9	COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,1S0KH@1236|Gammaproteobacteria,2NCCA@225057|Acidithiobacillales	225057|Acidithiobacillales	O	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_835382_1	590998.Celf_3406	1.85e-112	347.0	COG0277@1|root,COG2141@1|root,COG0277@2|Bacteria,COG2141@2|Bacteria,2GKRH@201174|Actinobacteria,4F27N@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,Bac_luciferase,FAD_binding_4,Hemerythrin
k59_1715295_1	1123320.KB889675_gene3974	1.59e-26	113.0	COG0477@1|root,COG2814@2|Bacteria,2H4H5@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K05557	-	-	-	-	ko00000,ko02000	2.A.1.3.7	-	-	MFS_1
k59_659634_1	1089551.KE386572_gene2469	1.26e-35	147.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria,4BR9R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Penicillin amidase	quiP	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_1250043_1	670307.HYPDE_41323	5.57e-25	107.0	COG4223@1|root,COG4223@2|Bacteria,1N3EE@1224|Proteobacteria,2VAHJ@28211|Alphaproteobacteria,3N97M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	DZ	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1597771_1	1713.JOFV01000013_gene1049	1.5e-11	63.9	COG0147@1|root,COG0147@2|Bacteria,2GKJT@201174|Actinobacteria,4F0MA@85016|Cellulomonadaceae	201174|Actinobacteria	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_911093_1	713586.KB900536_gene626	8.62e-37	141.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales	135613|Chromatiales	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_1494518_1	1123401.JHYQ01000003_gene2051	2.47e-93	284.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,1RP5V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	With LivFGHM is involved in the high affinity leucine transport	livK	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_725749_1	452637.Oter_0845	9.67e-25	104.0	COG2864@1|root,COG3005@1|root,COG2864@2|Bacteria,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB,Paired_CXXCH_1
k59_781070_1	1163617.SCD_n01356	1.56e-123	363.0	COG1638@1|root,COG1638@2|Bacteria,1PN6J@1224|Proteobacteria,2VSNQ@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_382820_1	187272.Mlg_1646	2.12e-151	447.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,1RPVI@1236|Gammaproteobacteria,1WXV7@135613|Chromatiales	135613|Chromatiales	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	glcB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_1431105_1	380394.Lferr_1358	9.61e-49	179.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,2NCDM@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Belongs to the UPF0753 family	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k59_1547120_1	477228.YO5_07002	4.03e-23	98.2	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1Z0J9@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010876,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0030203,GO:0031224,GO:0031226,GO:0033036,GO:0034203,GO:0034204,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097035,GO:1901135,GO:1901137,GO:1901264,GO:1901505,GO:1901564,GO:1901566,GO:1901576	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	iECO103_1326.ECO103_1114	MVIN
k59_1547120_2	1122599.AUGR01000024_gene1367	1.03e-07	50.1	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,1S9AI@1236|Gammaproteobacteria,1XKYP@135619|Oceanospirillales	135619|Oceanospirillales	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
k59_1723338_1	76636.JOEC01000003_gene1694	1.54e-71	228.0	COG1914@1|root,COG1914@2|Bacteria,2GJSM@201174|Actinobacteria,4FKID@85023|Microbacteriaceae	201174|Actinobacteria	P	Natural resistance-associated macrophage protein	mntH	GO:0000041,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006828,GO:0006829,GO:0008150,GO:0030001,GO:0034220,GO:0034755,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071421,GO:0071577,GO:0071578,GO:0072511,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098739,GO:0099587	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
k59_89269_1	1049564.TevJSym_at00140	9.52e-61	193.0	COG0235@1|root,COG0235@2|Bacteria,1RE8T@1224|Proteobacteria,1S3UF@1236|Gammaproteobacteria,1J69Y@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P)	mtnB	-	4.1.1.104,4.2.1.109	ko:K08964,ko:K22130	ko00270,ko01100,map00270,map01100	M00034	R07392	RC01939	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
k59_1260108_1	903818.KI912269_gene112	1.14e-99	323.0	COG0366@1|root,COG3408@1|root,COG0366@2|Bacteria,COG3408@2|Bacteria,3Y2ZW@57723|Acidobacteria	57723|Acidobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
k59_1196063_1	1122197.ATWI01000008_gene2824	3.95e-50	175.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,465QH@72275|Alteromonadaceae	1236|Gammaproteobacteria	CP	COG0651 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	phaD	-	1.6.5.3	ko:K00342,ko:K05561,ko:K05568	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M
k59_1431111_1	1167006.UWK_02541	3.4e-13	75.1	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2MMGR@213118|Desulfobacterales	28221|Deltaproteobacteria	T	CHASE2	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_268041_1	1232410.KI421415_gene2975	4.91e-127	377.0	COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,42MPG@68525|delta/epsilon subdivisions,2WKW8@28221|Deltaproteobacteria,43UK8@69541|Desulfuromonadales	28221|Deltaproteobacteria	HJ	RimK-like ATPgrasp N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Dala_Dala_lig_C,RLAN,RimK
k59_34423_1	1121033.AUCF01000008_gene5744	7.35e-45	158.0	COG0741@1|root,COG0741@2|Bacteria,1MUMA@1224|Proteobacteria,2TSA5@28211|Alphaproteobacteria,2JSV4@204441|Rhodospirillales	204441|Rhodospirillales	M	transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_1494554_1	396588.Tgr7_1464	1.29e-54	183.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,1WWK8@135613|Chromatiales	135613|Chromatiales	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
k59_197670_1	1380354.JIAN01000006_gene514	2.23e-80	242.0	COG0054@1|root,COG0054@2|Bacteria,2II1Z@201174|Actinobacteria,4F2FY@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
k59_382858_2	396588.Tgr7_0108	4.29e-65	203.0	COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria,1WWYM@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
k59_1371235_1	933262.AXAM01000029_gene2745	9.12e-66	210.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,42QE5@68525|delta/epsilon subdivisions,2WM8R@28221|Deltaproteobacteria,2MHVT@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
k59_549379_1	1453501.JELR01000002_gene766	9.03e-125	361.0	COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,1T1GE@1236|Gammaproteobacteria,4670C@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Integral membrane protein TerC family	ygdQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	TerC
k59_843288_1	880072.Desac_0736	1.94e-139	412.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,42PSJ@68525|delta/epsilon subdivisions,2WJDD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	reductase alpha subunit	aprA	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
k59_1085838_1	1454010.JEOE01000046_gene1943	2.3e-10	60.5	COG1846@1|root,COG1846@2|Bacteria,2HGXY@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	MarR
k59_1085838_2	211114.JOEF01000041_gene6022	3.56e-06	53.9	COG0628@1|root,COG0628@2|Bacteria,2GK0H@201174|Actinobacteria,4E8MG@85010|Pseudonocardiales	201174|Actinobacteria	S	AI-2E family transporter	-	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K20469	-	-	-	-	ko00000,ko02000	2.A.86.1.7	-	-	AI-2E_transport
k59_1494559_1	198628.Dda3937_00238	3.12e-54	179.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,2JDVT@204037|Dickeya	1236|Gammaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006780,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046394,GO:0046483,GO:0046501,GO:0046502,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO3734,iSBO_1134.SBO_4018	URO-D
k59_1494559_2	317619.ANKN01000230_gene216	9.71e-21	89.7	COG3001@1|root,COG3001@2|Bacteria,1G040@1117|Cyanobacteria,1MM08@1212|Prochloraceae	1117|Cyanobacteria	G	Ribulosamine erythrulosamine 3-kinase potentially involved in protein deglycation	-	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237	-	-	-	-	-	-	-	-	-	-	Fructosamin_kin
k59_490789_1	1254432.SCE1572_18575	1.76e-16	84.7	COG2267@1|root,COG2303@1|root,COG2267@2|Bacteria,COG2303@2|Bacteria,1QQ8F@1224|Proteobacteria,42PWF@68525|delta/epsilon subdivisions,2WKVA@28221|Deltaproteobacteria,2YYIQ@29|Myxococcales	28221|Deltaproteobacteria	E	GMC oxidoreductase	choD	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_549380_1	1449069.JMLO01000018_gene539	6.49e-31	115.0	COG1309@1|root,COG1309@2|Bacteria,2GV75@201174|Actinobacteria,4FX2S@85025|Nocardiaceae	201174|Actinobacteria	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
k59_549380_2	1151061.CAJY01000032_gene2184	2.41e-08	58.2	COG2267@1|root,COG2267@2|Bacteria,2I9XP@201174|Actinobacteria	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Hydrolase_4
k59_1322372_1	288705.RSal33209_2163	5.07e-09	53.5	COG0089@1|root,COG0089@2|Bacteria,2IQ7V@201174|Actinobacteria,1W9GE@1268|Micrococcaceae	201174|Actinobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_1322372_2	1095767.CAHD01000130_gene1300	5.14e-108	317.0	COG0088@1|root,COG0088@2|Bacteria,2GJYJ@201174|Actinobacteria,4F0Z8@85016|Cellulomonadaceae	201174|Actinobacteria	J	Forms part of the polypeptide exit tunnel	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_1431126_1	765910.MARPU_08845	2.03e-11	60.8	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1S8RQ@1236|Gammaproteobacteria,1WZ4Z@135613|Chromatiales	135613|Chromatiales	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
k59_1431126_2	95619.PM1_0221865	5.94e-101	305.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	ATPase related to the helicase subunit of the Holliday junction resolvase	rarA	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
k59_1850582_1	1177181.T9A_02225	2.46e-24	102.0	COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1XIJV@135619|Oceanospirillales	135619|Oceanospirillales	S	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_1850582_2	1121921.KB898714_gene1806	2.26e-41	144.0	COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,1RN6Q@1236|Gammaproteobacteria,2PN2K@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	F	Formyl transferase	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT,Formyl_trans_N
k59_1371243_1	1049564.TevJSym_ad00270	7.5e-124	369.0	COG1008@1|root,COG1008@2|Bacteria,1R6UV@1224|Proteobacteria,1S0HQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	overlaps another CDS with the same product name	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1085862_1	933262.AXAM01000067_gene855	1.26e-31	126.0	2A7N3@1|root,30WK3@2|Bacteria,1NERD@1224|Proteobacteria,42P7M@68525|delta/epsilon subdivisions,2WJTH@28221|Deltaproteobacteria,2MIHK@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_34466_1	1121405.dsmv_3065	5.07e-42	147.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,42N3Z@68525|delta/epsilon subdivisions,2WIPM@28221|Deltaproteobacteria,2MITD@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
k59_34466_2	879212.DespoDRAFT_01261	8.95e-37	128.0	COG1335@1|root,COG1335@2|Bacteria,1MU5N@1224|Proteobacteria,42RN4@68525|delta/epsilon subdivisions,2WP37@28221|Deltaproteobacteria,2MK0T@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM Isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_1781705_1	765912.Thimo_1486	8.51e-21	90.5	COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,1RQ6N@1236|Gammaproteobacteria,1WWGR@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1781705_2	1249627.D779_2934	1.67e-82	261.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1RSFG@1236|Gammaproteobacteria,1WW9R@135613|Chromatiales	135613|Chromatiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_1494581_1	502025.Hoch_0655	1.06e-131	412.0	COG3497@1|root,COG3497@2|Bacteria,1MX89@1224|Proteobacteria,42QD3@68525|delta/epsilon subdivisions,2WKMQ@28221|Deltaproteobacteria,2YZ9F@29|Myxococcales	28221|Deltaproteobacteria	S	Phage tail sheath protein subtilisin-like domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
k59_268104_1	553385.JEMF01000047_gene3323	1.66e-113	333.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1XHW3@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_432011_1	396588.Tgr7_0696	3.36e-81	256.0	COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1WWFZ@135613|Chromatiales	135613|Chromatiales	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase
k59_268106_1	301.JNHE01000004_gene1644	2.89e-27	115.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1YD4J@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	P	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
k59_1322406_1	566466.NOR53_3005	7.78e-58	195.0	COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,1RQJY@1236|Gammaproteobacteria,1J58C@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	COG2939 Carboxypeptidase C (cathepsin A)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
k59_911197_1	1082933.MEA186_33884	8.07e-47	168.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16,Trans_reg_C
k59_1666008_2	765911.Thivi_3158	1.91e-34	130.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXFK@135613|Chromatiales	135613|Chromatiales	GM	nucleoside-diphosphate sugar epimerase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
k59_1781716_1	317025.Tcr_1445	3.32e-27	112.0	COG5000@1|root,COG5000@2|Bacteria,1QUG9@1224|Proteobacteria,1T1Y1@1236|Gammaproteobacteria,460K3@72273|Thiotrichales	72273|Thiotrichales	T	PAS domain	-	-	2.7.13.3	ko:K10942	ko02020,ko05111,map02020,map05111	M00515	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_8
k59_726542_2	471853.Bcav_1010	6.27e-64	214.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1851913_1	1203554.HMPREF1476_02188	5.97e-45	158.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,2VI2X@28216|Betaproteobacteria,4PQC8@995019|Sutterellaceae	28216|Betaproteobacteria	E	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
k59_781731_2	639283.Snov_1456	2.93e-20	82.8	COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,2UF59@28211|Alphaproteobacteria,3F04F@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	Ribosomal L29 protein	rpmC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
k59_781731_3	314231.FP2506_06151	1.5e-22	88.2	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,2UBRF@28211|Alphaproteobacteria,2PK28@255475|Aurantimonadaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
k59_912404_1	375451.RD1_2370	4.25e-60	197.0	COG0583@1|root,COG0583@2|Bacteria,1PR6U@1224|Proteobacteria,2TUC6@28211|Alphaproteobacteria,2P128@2433|Roseobacter	28211|Alphaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1606005_1	330214.NIDE4063	9.47e-39	140.0	COG1748@1|root,COG1748@2|Bacteria	2|Bacteria	E	saccharopine dehydrogenase activity	lysDH	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP
k59_1606005_2	1385517.N800_05345	1.62e-56	189.0	COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,1RRMM@1236|Gammaproteobacteria,1X2YX@135614|Xanthomonadales	135614|Xanthomonadales	E	phospho-2-dehydro-3-deoxyheptonate aldolase	dhs1	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
k59_912409_1	1249627.D779_3177	2.46e-65	208.0	COG2242@1|root,COG2242@2|Bacteria,1R79F@1224|Proteobacteria,1RY3Z@1236|Gammaproteobacteria,1WX5D@135613|Chromatiales	135613|Chromatiales	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
k59_1431877_1	1192034.CAP_2889	2.07e-48	161.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,42RQ6@68525|delta/epsilon subdivisions,2WNCZ@28221|Deltaproteobacteria,2YV53@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
k59_550132_2	765912.Thimo_2956	3.85e-33	116.0	COG2154@1|root,COG2154@2|Bacteria,1N7XJ@1224|Proteobacteria,1T12K@1236|Gammaproteobacteria,1X2MX@135613|Chromatiales	135613|Chromatiales	H	Pterin 4 alpha carbinolamine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Pterin_4a
k59_1606007_1	765911.Thivi_0684	4.94e-54	181.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria,1WWQN@135613|Chromatiales	135613|Chromatiales	H	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
k59_668088_1	204669.Acid345_0942	1.15e-93	286.0	COG0334@1|root,COG0334@2|Bacteria,3Y3B4@57723|Acidobacteria,2JI4Q@204432|Acidobacteriia	2|Bacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_432765_1	497964.CfE428DRAFT_4653	1.96e-53	186.0	COG1199@1|root,COG1199@2|Bacteria,46SCS@74201|Verrucomicrobia	74201|Verrucomicrobia	L	SMART helicase c2	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
k59_1323658_2	479432.Sros_0582	2.96e-05	52.4	COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,4EGRX@85012|Streptosporangiales	201174|Actinobacteria	Q	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044464,GO:0071944	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_971495_1	1415780.JPOG01000001_gene3066	1.91e-50	170.0	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,1RPJA@1236|Gammaproteobacteria,1X57R@135614|Xanthomonadales	135614|Xanthomonadales	S	Predicted integral membrane protein (DUF2189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2189
k59_1666745_1	768671.ThimaDRAFT_0168	5.35e-96	305.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1WWSC@135613|Chromatiales	135613|Chromatiales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_384158_1	1123377.AUIV01000001_gene879	9.65e-40	147.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X34J@135614|Xanthomonadales	135614|Xanthomonadales	V	Efflux pump membrane transporter	mexB	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_384158_2	663610.JQKO01000010_gene2110	0.000297	44.7	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2TT21@28211|Alphaproteobacteria,3NANK@45404|Beijerinckiaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_90658_1	1123399.AQVE01000027_gene31	2.27e-66	225.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,4604N@72273|Thiotrichales	72273|Thiotrichales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_1495565_1	485916.Dtox_3192	7.13e-26	100.0	COG0779@1|root,COG0779@2|Bacteria,1V6KT@1239|Firmicutes,24N1G@186801|Clostridia,2629C@186807|Peptococcaceae	186801|Clostridia	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
k59_550154_1	556268.OFAG_00660	1.49e-46	170.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,472C3@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GAF_2,GGDEF,HAMP,PAS,PAS_3,PAS_4,PAS_9
k59_35892_1	1121468.AUBR01000023_gene2763	4.5e-86	275.0	COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1TRH3@1239|Firmicutes,24ATZ@186801|Clostridia,42FES@68295|Thermoanaerobacterales	186801|Clostridia	HP	TIGRFAM molybdenum cofactor synthesis	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
k59_781758_1	765910.MARPU_10275	1.49e-120	359.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,1RNQI@1236|Gammaproteobacteria,1WW64@135613|Chromatiales	135613|Chromatiales	M	Belongs to the mannose-6-phosphate isomerase type 2 family	-	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_1135036_1	882378.RBRH_00926	1.05e-77	249.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,2VHA7@28216|Betaproteobacteria,1K1JB@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_912465_1	883.DvMF_0705	6.64e-55	193.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1QFX3@1224|Proteobacteria,42PIP@68525|delta/epsilon subdivisions,2WKWI@28221|Deltaproteobacteria,2MG9J@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Pyruvate phosphate dikinase, PEP pyruvate-binding	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_971521_1	686340.Metal_2634	1.26e-54	201.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1XETE@135618|Methylococcales	135618|Methylococcales	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA_C
k59_315762_1	1255043.TVNIR_1944	4.14e-104	316.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1WXM2@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_668110_1	1125863.JAFN01000001_gene1803	2e-07	58.2	COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,42STV@68525|delta/epsilon subdivisions,2WKKA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Tellurite resistance protein TerB	-	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
k59_139882_1	765911.Thivi_1410	2.36e-57	186.0	29Y76@1|root,30K0S@2|Bacteria,1N3S0@1224|Proteobacteria,1SNR1@1236|Gammaproteobacteria,1X0NU@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF3611)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3611
k59_90690_1	765911.Thivi_3617	2.03e-100	296.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,1WWQJ@135613|Chromatiales	135613|Chromatiales	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
k59_1606037_1	935863.AWZR01000002_gene1145	3.38e-100	308.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1X4N0@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
k59_1371944_1	1713.JOFV01000005_gene2187	8.69e-104	311.0	COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria,4F13G@85016|Cellulomonadaceae	201174|Actinobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	GO:0008150,GO:0040007	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_432793_1	1232410.KI421421_gene3709	1.95e-97	295.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,43TW1@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1862667_1	385682.AFSL01000088_gene913	3.83e-45	161.0	COG0501@1|root,COG0501@2|Bacteria,4NESF@976|Bacteroidetes,2FPDQ@200643|Bacteroidia,3XJ8P@558415|Marinilabiliaceae	976|Bacteroidetes	O	CAAX prenyl protease N-terminal, five membrane helices	-	-	3.4.24.84	ko:K03799,ko:K06013	ko00900,ko01130,map00900,map01130	M00743	R09845	RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
k59_277336_1	446466.Cfla_1220	2e-64	208.0	COG5002@1|root,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4F13N@85016|Cellulomonadaceae	201174|Actinobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_277336_2	1454010.JEOE01000033_gene2935	2.12e-12	65.5	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria,4F0QK@85016|Cellulomonadaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	cseB	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_1202715_1	335543.Sfum_1977	6.11e-79	260.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MQTI@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
k59_394671_1	439235.Dalk_1624	1.06e-51	183.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MQ2S@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
k59_1611765_1	666681.M301_2066	4.78e-100	305.0	COG3547@1|root,COG3547@2|Bacteria,1QYJU@1224|Proteobacteria,2W4PJ@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_20
k59_732634_1	398580.Dshi_3172	1.84e-22	99.4	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2TVHI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome D1 heme domain	nirN	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_732634_2	991905.SL003B_0569	4.5e-28	110.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2TTS5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	biosynthesis protein E	nirJ	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
k59_1140157_2	1122197.ATWI01000008_gene2982	3.8e-84	262.0	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,464WH@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	Reduces the stability of FtsZ polymers in the presence of ATP	zapE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032153,GO:0044424,GO:0044464,GO:0051301	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
k59_982193_1	1123487.KB892868_gene1249	5.86e-47	170.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,2KVJT@206389|Rhodocyclales	206389|Rhodocyclales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1730152_1	713586.KB900536_gene2869	1.91e-88	275.0	COG0312@1|root,COG0312@2|Bacteria,1NSH6@1224|Proteobacteria,1RR3H@1236|Gammaproteobacteria,1WW71@135613|Chromatiales	135613|Chromatiales	S	modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
k59_394682_1	1095767.CAHD01000005_gene2435	6.1e-156	464.0	COG1012@1|root,COG1454@1|root,COG1012@2|Bacteria,COG1454@2|Bacteria,2GJI2@201174|Actinobacteria,4F0XP@85016|Cellulomonadaceae	201174|Actinobacteria	C	belongs to the iron- containing alcohol dehydrogenase family	adhE	-	1.1.1.1,1.2.1.10,1.2.1.81	ko:K04072,ko:K15515	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	-	R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh,Fe-ADH
k59_497573_1	1249627.D779_4113	2.31e-164	507.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon
k59_394692_1	765913.ThidrDRAFT_4551	1.6e-53	179.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1WXQP@135613|Chromatiales	135613|Chromatiales	U	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_1437816_1	1125863.JAFN01000001_gene2425	4.7e-10	60.8	COG4656@1|root,COG4656@2|Bacteria,1PJE1@1224|Proteobacteria,42P69@68525|delta/epsilon subdivisions,2WIM9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB
k59_1437816_2	1000565.METUNv1_00425	1.2e-51	169.0	COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,2VN5I@28216|Betaproteobacteria,2KVNK@206389|Rhodocyclales	206389|Rhodocyclales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4_21
k59_1730165_1	870967.VIS19158_20082	1.13e-06	47.0	2AXU7@1|root,31PV8@2|Bacteria,1QMI8@1224|Proteobacteria,1TJTK@1236|Gammaproteobacteria,1Y1NS@135623|Vibrionales	135623|Vibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1787436_1	1249627.D779_3611	2.95e-37	141.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1WWHQ@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_1021605_1	222534.KB893739_gene1479	2.16e-28	117.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4EXCJ@85013|Frankiales	201174|Actinobacteria	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_1334418_1	977880.RALTA_A2871	3.51e-50	165.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2VJPI@28216|Betaproteobacteria,1K0YG@119060|Burkholderiaceae	28216|Betaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_1334418_2	882378.RBRH_02288	3.33e-13	67.4	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2VI38@28216|Betaproteobacteria,1K1DU@119060|Burkholderiaceae	28216|Betaproteobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_44338_1	933262.AXAM01000016_gene165	1.98e-99	296.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2WJY0@28221|Deltaproteobacteria,2MI2P@213118|Desulfobacterales	28221|Deltaproteobacteria	F	PFAM SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
k59_674126_2	886293.Sinac_4715	3.08e-15	80.1	COG0568@1|root,COG0568@2|Bacteria,2IY72@203682|Planctomycetes	203682|Planctomycetes	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03086,ko:K03093	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
k59_1672749_1	338966.Ppro_1571	1.28e-153	445.0	COG3961@1|root,COG3961@2|Bacteria,1MW2F@1224|Proteobacteria,42NMB@68525|delta/epsilon subdivisions,2WKP7@28221|Deltaproteobacteria,43TST@69541|Desulfuromonadales	28221|Deltaproteobacteria	GH	Belongs to the TPP enzyme family	-	-	4.1.1.74	ko:K04103	ko00380,ko01100,map00380,map01100	-	R01974	RC00506	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1140181_1	1168067.JAGP01000001_gene1537	6.08e-34	118.0	COG0727@1|root,COG0727@2|Bacteria,1MZPF@1224|Proteobacteria,1S8T7@1236|Gammaproteobacteria,462MT@72273|Thiotrichales	72273|Thiotrichales	S	Putative zinc- or iron-chelating domain	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
k59_1140181_2	765911.Thivi_3983	4.14e-27	104.0	COG0529@1|root,COG0529@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria,1WY0V@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
k59_1377699_1	640512.BC1003_4750	1.2e-37	145.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,1KG5N@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	amp-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,Acyltransferase,PP-binding
k59_674133_1	1288826.MSNKSG1_18315	2.11e-103	335.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,465BS@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	COG0067 Glutamate synthase domain 1	gltB	GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iBWG_1329.BWG_2914,iECDH10B_1368.ECDH10B_3387,iECDH1ME8569_1439.EcDH1_0495,iEcDH1_1363.EcDH1_0495,iPC815.YPO3557	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_145873_1	221288.JH992901_gene2043	4.43e-23	104.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1JHSG@1189|Stigonemataceae	1117|Cyanobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9
k59_923184_1	765911.Thivi_0921	1.46e-100	301.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RMN3@1236|Gammaproteobacteria,1WW1E@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_556169_1	243233.MCA1475	2.55e-214	614.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1XEQR@135618|Methylococcales	135618|Methylococcales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_1672760_1	340.xcc-b100_0919	6.5e-24	96.7	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,1RNF8@1236|Gammaproteobacteria,1X403@135614|Xanthomonadales	135614|Xanthomonadales	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
k59_1334441_1	768671.ThimaDRAFT_1425	4.88e-40	138.0	COG2941@1|root,COG2941@2|Bacteria,1RAA1@1224|Proteobacteria,1RPMV@1236|Gammaproteobacteria,1WWM4@135613|Chromatiales	135613|Chromatiales	H	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol	coq7	-	-	ko:K06134	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00128	R04984,R08775	RC01254	ko00000,ko00001,ko00002,ko01000	-	-	-	COQ7
k59_1334441_2	1255043.TVNIR_0365	7.46e-15	78.2	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1WWXD@135613|Chromatiales	135613|Chromatiales	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_17,Fer4_7,Fer4_8
k59_1334442_1	1162668.LFE_2212	2.3e-84	261.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	5.3.1.12	ko:K01812,ko:K02529,ko:K16210	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	2.A.2.5	-	-	DDE_Tnp_ISAZ013,Peripla_BP_3
k59_1437838_1	1219076.N646_4010	3.84e-45	167.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1XVAE@135623|Vibrionales	135623|Vibrionales	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	-	ko:K05565	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,NADH5_C,Proton_antipo_M,Proton_antipo_N
k59_145880_1	1121459.AQXE01000001_gene2827	6.31e-82	261.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2M88M@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_674142_1	555779.Dthio_PD3174	5.66e-64	213.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,42P1M@68525|delta/epsilon subdivisions,2WKJ2@28221|Deltaproteobacteria,2M9BD@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	PFAM peptidase M48 Ste24p	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
k59_674142_2	497964.CfE428DRAFT_1483	4.68e-07	50.4	COG0436@1|root,COG0436@2|Bacteria,46TMR@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	-	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_849919_1	749927.AMED_3573	2.26e-14	78.6	COG4995@1|root,COG4995@2|Bacteria,2IJMG@201174|Actinobacteria	201174|Actinobacteria	S	SIR2-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,SIR2_2
k59_786783_1	760117.JN27_09435	9.55e-57	195.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,4735B@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1437843_1	713586.KB900536_gene3003	5.3e-07	52.4	COG1716@1|root,COG1716@2|Bacteria,1PGN8@1224|Proteobacteria,1SEK2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
k59_1437843_2	314287.GB2207_04099	2.94e-45	154.0	29B18@1|root,2ZY02@2|Bacteria,1REMG@1224|Proteobacteria,1S4B1@1236|Gammaproteobacteria,1JA2W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_556185_1	1035191.HMPREF0185_02589	5.73e-90	290.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria,2KFVI@204458|Caulobacterales	204458|Caulobacterales	S	PFAM peptidase M16 domain protein	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_614815_1	398511.BpOF4_12185	1.46e-06	53.9	COG1595@1|root,COG1595@2|Bacteria,1V9ZH@1239|Firmicutes,4HGNB@91061|Bacilli,1ZGEX@1386|Bacillus	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1202775_1	1121033.AUCF01000029_gene299	5.43e-59	193.0	28PES@1|root,2ZC68@2|Bacteria,1RBB8@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1672782_1	1054213.HMPREF9946_02640	9.41e-70	235.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JQH0@204441|Rhodospirillales	204441|Rhodospirillales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K21134	-	M00821	-	-	ko00000,ko00002,ko02000	2.A.6.2.27	-	-	ACR_tran
k59_145901_1	1172180.KB911792_gene3696	1.61e-107	327.0	COG1155@1|root,COG1155@2|Bacteria,2HESQ@201174|Actinobacteria	201174|Actinobacteria	C	ATPsynthase alpha/beta subunit N-term extension	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_923219_1	102129.Lepto7375DRAFT_3127	1.41e-23	97.8	COG0454@1|root,COG0454@2|Bacteria,1G5K5@1117|Cyanobacteria,1HCUQ@1150|Oscillatoriales	1117|Cyanobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_321774_3	1380347.JNII01000007_gene407	1.77e-81	268.0	COG0438@1|root,COG0438@2|Bacteria,2I6NY@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
k59_394768_1	1121121.KB894284_gene486	5.37e-78	256.0	COG0247@1|root,COG0348@1|root,COG0247@2|Bacteria,COG0348@2|Bacteria,1TPG1@1239|Firmicutes,4HB2J@91061|Bacilli,26QYF@186822|Paenibacillaceae	91061|Bacilli	C	4Fe-4S dicluster domain	ywjF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_438868_1	1122185.N792_12495	7.15e-123	365.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1X4FV@135614|Xanthomonadales	135614|Xanthomonadales	C	IG-like fold at C-terminal of FixG, putative oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
k59_732705_1	382464.ABSI01000023_gene560	1.3e-59	200.0	COG0064@1|root,COG0064@2|Bacteria,46S5X@74201|Verrucomicrobia,2ITJA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_1335459_2	1163617.SCD_n01356	6.47e-75	234.0	COG1638@1|root,COG1638@2|Bacteria,1PN6J@1224|Proteobacteria,2VSNQ@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1140733_1	1267005.KB911259_gene3845	5.88e-91	286.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2TS0S@28211|Alphaproteobacteria,3N7Z1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
k59_1203394_1	314278.NB231_12691	2.09e-81	266.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales	135613|Chromatiales	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_983274_1	258594.RPA4721	1.26e-12	68.6	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,2U2F7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_983274_2	1123228.AUIH01000057_gene3707	7.46e-37	138.0	COG2304@1|root,COG2304@2|Bacteria,1PDQV@1224|Proteobacteria,1RPGD@1236|Gammaproteobacteria,1XN5K@135619|Oceanospirillales	135619|Oceanospirillales	NT	FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP_2
k59_1438485_1	926569.ANT_30570	2.89e-91	278.0	COG4956@1|root,COG4956@2|Bacteria,2G5YK@200795|Chloroflexi	200795|Chloroflexi	S	SMART Nucleotide binding protein, PINc	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
k59_498255_1	1121405.dsmv_1968	4.5e-71	219.0	COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,42U8S@68525|delta/epsilon subdivisions,2WQ8V@28221|Deltaproteobacteria,2MKT7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	nuoE-1	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_498255_2	760568.Desku_3135	5.93e-10	61.6	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,24D58@186801|Clostridia,2618B@186807|Peptococcaceae	186801|Clostridia	C	NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_1335464_1	1071679.BG57_19475	6.74e-134	393.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2VJHJ@28216|Betaproteobacteria,1K2U2@119060|Burkholderiaceae	28216|Betaproteobacteria	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k59_1335464_2	1178482.BJB45_17795	2.68e-222	625.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria,1XI3H@135619|Oceanospirillales	135619|Oceanospirillales	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.113	ko:K12256	ko00330,ko01100,map00330,map01100	-	R08714	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_733402_2	237368.SCABRO_03231	8.55e-47	154.0	COG4828@1|root,COG4828@2|Bacteria,2J4U0@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1622)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1622
k59_1140741_1	311403.Arad_2003	2.42e-37	127.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,2U73D@28211|Alphaproteobacteria,4BE27@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_1094242_1	1157635.KB892009_gene3393	2.02e-25	106.0	COG1735@1|root,COG1735@2|Bacteria,2GMZ6@201174|Actinobacteria	201174|Actinobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	ko:K07048	-	-	-	-	ko00000	-	-	-	PTE
k59_983286_1	335543.Sfum_1994	3.01e-24	106.0	COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,43C2J@68525|delta/epsilon subdivisions,2X7D5@28221|Deltaproteobacteria,2MQEP@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
k59_1554305_1	1123519.PSJM300_13315	1.41e-135	402.0	COG0028@1|root,COG0028@2|Bacteria,1P76A@1224|Proteobacteria,1RP3S@1236|Gammaproteobacteria,1Z0H2@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	EH	COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_322422_1	243233.MCA1114	1.75e-116	352.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1XE8Y@135618|Methylococcales	135618|Methylococcales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_674856_1	1386089.N865_00055	2.89e-66	219.0	COG1271@1|root,COG1271@2|Bacteria,2GJE4@201174|Actinobacteria,4FFIS@85021|Intrasporangiaceae	201174|Actinobacteria	C	cytochrome bd ubiquinol oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_924224_1	1056820.KB900632_gene2210	1.2e-79	251.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,1RNXE@1236|Gammaproteobacteria,2PMN4@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	K	Segregation and condensation complex subunit ScpB	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
k59_924224_2	1415778.JQMM01000001_gene2026	4.67e-14	71.2	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,1RQU0@1236|Gammaproteobacteria,1J4GT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_205163_1	314278.NB231_17318	6.73e-13	67.0	COG0582@1|root,COG0582@2|Bacteria,1P1R9@1224|Proteobacteria,1RRV0@1236|Gammaproteobacteria,1WZGX@135613|Chromatiales	135613|Chromatiales	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
k59_205163_2	768671.ThimaDRAFT_0298	4.53e-95	287.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1WWA7@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_1673457_1	1236541.BALL01000024_gene2926	1.9e-48	169.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria,2QAJ6@267890|Shewanellaceae	1236|Gammaproteobacteria	C	PFAM FAD dependent oxidoreductase	eryB	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO
k59_1268519_1	391625.PPSIR1_13430	5.46e-18	84.7	COG5587@1|root,COG5587@2|Bacteria,1R8B4@1224|Proteobacteria,42RKE@68525|delta/epsilon subdivisions,2WS0D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
k59_1612527_1	1437882.AZRU01000001_gene2167	8.59e-53	184.0	COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1YDHM@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily	gshA	GO:0003674,GO:0003824,GO:0004357,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0010038,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042221,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046685,GO:0046689,GO:0046872,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0070887,GO:0071241,GO:0071243,GO:0071248,GO:0071288,GO:0071704,GO:1901564,GO:1901566,GO:1901576	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	iEC042_1314.EC042_2885	Glu_cys_ligase
k59_1673462_1	1379698.RBG1_1C00001G0216	6.47e-32	125.0	COG0845@1|root,COG0845@2|Bacteria,2NPBH@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
k59_850590_1	1380394.JADL01000009_gene3266	9.14e-88	268.0	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,2TRRU@28211|Alphaproteobacteria,2JQ4F@204441|Rhodospirillales	204441|Rhodospirillales	GK	ROK family	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	ROK
k59_850590_2	498211.CJA_2653	9.02e-06	53.1	COG3725@1|root,COG3725@2|Bacteria,1MYFA@1224|Proteobacteria,1SE2J@1236|Gammaproteobacteria,1FG90@10|Cellvibrio	1236|Gammaproteobacteria	V	Membrane protein required for beta-lactamase induction	ampE	-	-	ko:K03807	-	-	-	-	ko00000	-	-	-	CobD_Cbib
k59_1144375_1	335543.Sfum_0676	2.71e-57	191.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2WIN7@28221|Deltaproteobacteria,2MQWN@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Biotin carboxylase C-terminal domain	accC	-	6.3.4.14,6.4.1.1,6.4.1.2	ko:K01959,ko:K01961	ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230	M00082,M00173,M00376,M00620	R00344,R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_1207490_1	765913.ThidrDRAFT_4071	7.11e-113	337.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1WX8S@135613|Chromatiales	135613|Chromatiales	P	PFAM phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_1558488_2	1158756.AQXQ01000012_gene1997	3.02e-51	165.0	2BK43@1|root,32EHP@2|Bacteria,1RDAC@1224|Proteobacteria,1S4CA@1236|Gammaproteobacteria,1WY9U@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_990199_1	713586.KB900536_gene449	1.8e-40	145.0	COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,1RMYN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_990199_2	458817.Shal_1375	9.33e-08	54.7	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,2Q8SD@267890|Shewanellaceae	1236|Gammaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_1342424_1	247634.GPB2148_793	1.42e-111	331.0	COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,1RQBF@1236|Gammaproteobacteria,1J62W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the peptidase S11 family	pbpG	GO:0003674,GO:0003824,GO:0004175,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K07262	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
k59_326569_1	1033802.SSPSH_000418	4.33e-95	293.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	glnG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_51198_1	1296415.JACC01000015_gene826	9.48e-80	253.0	COG4147@1|root,COG4147@2|Bacteria,4NHPT@976|Bacteroidetes,1HXQN@117743|Flavobacteriia,2YHN0@290174|Aquimarina	976|Bacteroidetes	S	Sodium:solute symporter family	actP	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_51198_2	1131269.AQVV01000016_gene1854	1e-19	82.4	COG4327@1|root,COG4327@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4212)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4212
k59_560911_1	500635.MITSMUL_05393	2.5e-46	161.0	COG0416@1|root,COG0416@2|Bacteria,1TPXS@1239|Firmicutes,4H1ZZ@909932|Negativicutes	909932|Negativicutes	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_402634_1	562973.HMPREF0059_00803	3.34e-44	154.0	COG0152@1|root,COG0152@2|Bacteria,2GK3H@201174|Actinobacteria,4D3WQ@85005|Actinomycetales	201174|Actinobacteria	F	Belongs to the SAICAR synthetase family	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01923,ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
k59_931951_1	1547437.LL06_04450	2.07e-89	275.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2U3I9@28211|Alphaproteobacteria,43IG3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K00895,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_991153_1	859657.RPSI07_2230	1.18e-11	67.4	COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria,1K0WM@119060|Burkholderiaceae	28216|Betaproteobacteria	M	(Lipo)protein	nlpB	-	-	ko:K07287	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	Lipoprotein_18
k59_991153_2	396588.Tgr7_0827	2.35e-64	205.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1WWMV@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_620171_1	1121937.AUHJ01000009_gene1553	1.71e-94	293.0	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,1RNS0@1236|Gammaproteobacteria,46ADA@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Cytochrome D1 heme domain	nirS	-	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_738459_1	550540.Fbal_1356	1.5e-52	177.0	COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria,1RZUI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	cytochrome C family protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Paired_CXXCH_1
k59_1871571_1	1121124.JNIX01000008_gene2429	8.66e-95	281.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2TSAM@28211|Alphaproteobacteria,2KEZ9@204458|Caulobacterales	204458|Caulobacterales	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_1871571_2	768671.ThimaDRAFT_2440	1.62e-16	79.3	COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1WWZ8@135613|Chromatiales	135613|Chromatiales	S	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_931960_1	349521.HCH_00031	1.57e-46	162.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1XIPZ@135619|Oceanospirillales	135619|Oceanospirillales	S	protein containing LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_51869_1	1049564.TevJSym_ap00050	1.09e-109	342.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J57S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	cation transport ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
k59_327264_1	941449.dsx2_2253	7.59e-05	50.1	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,42MX3@68525|delta/epsilon subdivisions,2WKI4@28221|Deltaproteobacteria,2MA90@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Transglycosylase SLT domain	-	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
k59_738468_2	1121920.AUAU01000004_gene751	4.01e-56	188.0	COG1748@1|root,COG1748@2|Bacteria,3Y84N@57723|Acidobacteria	57723|Acidobacteria	E	Saccharopine dehydrogenase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_1735611_1	1267533.KB906733_gene3355	5.89e-33	133.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_1871588_1	880072.Desac_1967	5.4e-88	279.0	COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria,2MQWJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit	-	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
k59_738469_1	697282.Mettu_0192	8.84e-24	99.4	29SM0@1|root,30DSB@2|Bacteria,1RFFC@1224|Proteobacteria,1T0JT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF4239)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4239
k59_738469_2	1190603.AJYD01000041_gene2689	2.37e-13	70.5	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,1RQN1@1236|Gammaproteobacteria,1XU72@135623|Vibrionales	135623|Vibrionales	S	transport system periplasmic component	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_284613_1	1249627.D779_0248	6.23e-114	345.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1WXXQ@135613|Chromatiales	135613|Chromatiales	G	Alpha amylase catalytic	-	-	2.4.1.7	ko:K00690	ko00500,map00500	-	R00803	RC00028	ko00000,ko00001,ko01000	-	GH13	-	-
k59_1343400_2	323261.Noc_2339	1.08e-57	188.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria,1WWNR@135613|Chromatiales	135613|Chromatiales	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2,5.1.3.5	ko:K01784,ko:K12448	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R01473,R02984	RC00289,RC00528	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_444332_1	1454010.JEOE01000002_gene369	4.24e-72	235.0	COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria,4F0ST@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_1443351_1	255470.cbdbA133	2.96e-48	171.0	COG0842@1|root,COG0842@2|Bacteria,2G7IS@200795|Chloroflexi,34CUZ@301297|Dehalococcoidia	301297|Dehalococcoidia	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_991184_1	1121035.AUCH01000003_gene1322	1.45e-22	95.1	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,2VIRF@28216|Betaproteobacteria,2KVDF@206389|Rhodocyclales	206389|Rhodocyclales	E	periplasmic protein kinase ArgK and related GTPases of G3E family	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
k59_991184_2	1223521.BBJX01000004_gene2554	4.93e-115	351.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VIT2@28216|Betaproteobacteria,4AA6N@80864|Comamonadaceae	28216|Betaproteobacteria	I	Methylmalonyl-CoA mutase large subunit	icmF	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
k59_1559268_2	765910.MARPU_13475	7.98e-22	94.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,1WXMF@135613|Chromatiales	135613|Chromatiales	O	PFAM Thioredoxin	-	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_1443353_1	699246.HMPREF0868_1537	4.47e-82	251.0	COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,247XY@186801|Clostridia,267V8@186813|unclassified Clostridiales	186801|Clostridia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_1735618_1	1307761.L21SP2_2617	4.22e-78	250.0	COG0621@1|root,COG0621@2|Bacteria,2J5GF@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_1735618_2	755732.Fluta_3781	2.73e-15	75.9	COG3177@1|root,COG3177@2|Bacteria	2|Bacteria	D	Filamentation induced by cAMP protein fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic,HTH_17
k59_327275_1	1223521.BBJX01000007_gene1539	7.41e-71	224.0	COG2423@1|root,COG2423@2|Bacteria,1MWH6@1224|Proteobacteria,2VHIM@28216|Betaproteobacteria,4ABP6@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM Ornithine cyclodeaminase mu-crystallin	arcB	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
k59_327275_2	391735.Veis_0965	2.24e-21	92.0	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2VJU2@28216|Betaproteobacteria,4AB3J@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the arginase family	rocF	-	3.5.3.1,3.5.3.11,3.5.3.17,3.5.3.7	ko:K01476,ko:K01480,ko:K12255,ko:K18459	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00133,M00134	R00551,R01157,R01990	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
k59_403588_2	631362.Thi970DRAFT_04444	1.08e-68	226.0	COG3464@1|root,COG3464@2|Bacteria,1N5CJ@1224|Proteobacteria,1T4WB@1236|Gammaproteobacteria,1WZSX@135613|Chromatiales	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_991198_1	367299.JOEE01000001_gene1633	9.81e-104	311.0	COG0477@1|root,COG2814@2|Bacteria,2GK8C@201174|Actinobacteria,4FFBF@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	transporter	araJ	-	-	ko:K19577	-	-	-	-	ko00000,ko02000	2.A.1.2.65	-	-	MFS_1,Sugar_tr
k59_679883_1	580340.Tlie_0501	4.59e-65	209.0	COG0628@1|root,COG0628@2|Bacteria,3T9W6@508458|Synergistetes	508458|Synergistetes	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1383489_1	243233.MCA0509	1.21e-175	503.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1XDTS@135618|Methylococcales	135618|Methylococcales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
k59_1343419_1	666685.R2APBS1_0864	3.96e-60	216.0	COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1X3AY@135614|Xanthomonadales	135614|Xanthomonadales	T	Chemotaxis protein histidine kinase and related kinases	pilL	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_1099511_1	977880.RALTA_A1894	1.07e-80	264.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,1K3JV@119060|Burkholderiaceae	28216|Betaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_1792282_1	1163617.SCD_n02729	1.33e-123	362.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,2VI9A@28216|Betaproteobacteria	28216|Betaproteobacteria	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
k59_110086_2	196162.Noca_4470	2.17e-72	221.0	COG3260@1|root,COG3260@2|Bacteria,2IDTD@201174|Actinobacteria,4DUTR@85009|Propionibacteriales	201174|Actinobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	hycG	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
k59_991221_2	1528106.JRJE01000006_gene1097	2.6e-06	50.1	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2JQKA@204441|Rhodospirillales	204441|Rhodospirillales	P	COG2217 Cation transport ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_284652_1	290317.Cpha266_2265	4.22e-33	118.0	COG1396@1|root,COG1396@2|Bacteria,1FFMJ@1090|Chlorobi	1090|Chlorobi	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1871641_1	224911.27351252	7.15e-121	362.0	COG4303@1|root,COG4303@2|Bacteria,1MUR4@1224|Proteobacteria,2TTNA@28211|Alphaproteobacteria,3JSC5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Ethanolamine ammonia lyase large subunit (EutB)	MA20_16105	-	4.3.1.7	ko:K03735	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001,ko01000	-	-	-	EutB
k59_1871641_2	1168059.KB899087_gene481	3.21e-45	164.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2TR6F@28211|Alphaproteobacteria,3EYGW@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_1735644_1	395493.BegalDRAFT_0212	8.97e-152	438.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,460AT@72273|Thiotrichales	72273|Thiotrichales	C	Belongs to the heme-copper respiratory oxidase family	-	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_1735644_2	983917.RGE_31920	6.48e-33	119.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2VIJ2@28216|Betaproteobacteria,1KJRV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	cytochrome C oxidase	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
k59_991230_1	1122622.ATWJ01000008_gene2997	5.45e-28	111.0	COG0151@1|root,COG0151@2|Bacteria,2I7DG@201174|Actinobacteria,4FK12@85021|Intrasporangiaceae	201174|Actinobacteria	F	Carbamoyl-phosphate synthase L chain, ATP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CPSase_L_D2
k59_991230_2	1386089.N865_08430	1.45e-100	299.0	COG4947@1|root,COG4947@2|Bacteria,2I9H9@201174|Actinobacteria,4FFF6@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_561598_2	634500.EbC_35210	6.79e-26	107.0	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,1RU8R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Amidases related to nicotinamidase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_561598_4	28444.JODQ01000013_gene2840	2.87e-64	214.0	COG0154@1|root,COG0154@2|Bacteria,2GSBS@201174|Actinobacteria,4ENHI@85012|Streptosporangiales	201174|Actinobacteria	J	Amidase	-	-	3.5.1.54	ko:K01457	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120	-	R00005	RC02756	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_1443388_1	207954.MED92_04507	9.35e-78	234.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,1XJC8@135619|Oceanospirillales	135619|Oceanospirillales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_1145036_2	443143.GM18_0341	2.72e-78	258.0	COG2133@1|root,COG2133@2|Bacteria,1NRFC@1224|Proteobacteria,42YAV@68525|delta/epsilon subdivisions,2WTUF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1026246_1	367299.JOEE01000005_gene3435	1.46e-86	266.0	COG4825@1|root,COG4825@2|Bacteria,2GPAA@201174|Actinobacteria,4FE5T@85021|Intrasporangiaceae	201174|Actinobacteria	S	Thiamin pyrophosphokinase	-	-	-	-	-	-	-	-	-	-	-	-	TPPK_C
k59_561599_1	1278073.MYSTI_04285	6.36e-63	206.0	COG0252@1|root,COG0252@2|Bacteria,1MWIR@1224|Proteobacteria,42MA1@68525|delta/epsilon subdivisions,2WPWQ@28221|Deltaproteobacteria,2Z1GV@29|Myxococcales	28221|Deltaproteobacteria	EJ	Asparaginase	ansB	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
k59_503012_1	933262.AXAM01000017_gene3145	1.98e-61	212.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2
k59_327314_1	391008.Smal_0159	1.57e-51	174.0	COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,1RNBX@1236|Gammaproteobacteria,1X45S@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyl-CoA dehydrogenase	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1026252_1	319224.Sputcn32_3224	1.44e-91	286.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,2QA5R@267890|Shewanellaceae	1236|Gammaproteobacteria	M	gamma-glutamyltransferase	ggt_2	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_738524_1	439235.Dalk_3962	2.36e-92	283.0	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,42MPB@68525|delta/epsilon subdivisions,2WJUV@28221|Deltaproteobacteria,2MJ5P@213118|Desulfobacterales	28221|Deltaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB2	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_791286_1	62928.azo2158	2.08e-22	99.4	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria,2KVJB@206389|Rhodocyclales	206389|Rhodocyclales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_1735665_1	870187.Thini_0203	1.66e-26	108.0	COG4196@1|root,COG4196@2|Bacteria,1R6II@1224|Proteobacteria,1SKHQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Putative amidoligase enzyme (DUF2126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2126
k59_1735665_2	1209072.ALBT01000066_gene1107	7.66e-51	180.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,1FGZ5@10|Cellvibrio	1236|Gammaproteobacteria	E	Putative amidoligase enzyme (DUF2126)	IV02_11925	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
k59_403654_1	243233.MCA3033	2.23e-23	99.4	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1XDZC@135618|Methylococcales	135618|Methylococcales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_1678361_1	240016.ABIZ01000001_gene3547	1.4e-88	266.0	COG1136@1|root,COG1136@2|Bacteria,46UWZ@74201|Verrucomicrobia,2IVI3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_317081_1	1234364.AMSF01000066_gene2273	8.18e-79	250.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria,1X31X@135614|Xanthomonadales	135614|Xanthomonadales	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	etf-QO	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8,Thi4
k59_317081_2	1149133.ppKF707_4199	1.58e-05	47.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,1RPGT@1236|Gammaproteobacteria,1YE4H@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	Acetyl-coenzyme A synthetase N-terminus	acsA	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1326127_1	367299.JOEE01000004_gene967	1.32e-154	441.0	COG1088@1|root,COG1088@2|Bacteria,2GNDU@201174|Actinobacteria,4FFXC@85021|Intrasporangiaceae	201174|Actinobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
k59_1854428_1	1460635.JCM19038_1485	7.23e-21	96.3	COG1502@1|root,COG1502@2|Bacteria,1TPKY@1239|Firmicutes,4H9TI@91061|Bacilli	91061|Bacilli	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
k59_1018344_1	382464.ABSI01000006_gene815	7.04e-148	491.0	COG0771@1|root,COG2911@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,46UDY@74201|Verrucomicrobia,2IWGN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	Q	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_975199_1	384765.SIAM614_02591	4.96e-43	157.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1668725_1	768671.ThimaDRAFT_1009	2.76e-43	151.0	COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,1RY2B@1236|Gammaproteobacteria,1WY1Q@135613|Chromatiales	135613|Chromatiales	S	PFAM transport-associated	-	-	-	-	-	-	-	-	-	-	-	-	BON
k59_1549677_1	279714.FuraDRAFT_2624	4.19e-154	464.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2VJ54@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
k59_38660_1	1038860.AXAP01000006_gene6812	1.07e-22	99.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,2TTI6@28211|Alphaproteobacteria,3JQYI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_783461_1	446471.Xcel_0484	1.1e-143	462.0	COG4733@1|root,COG4733@2|Bacteria,2GMKC@201174|Actinobacteria,4F390@85017|Promicromonosporaceae	201174|Actinobacteria	S	fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
k59_493536_1	870187.Thini_1269	8.45e-148	426.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,4606V@72273|Thiotrichales	72273|Thiotrichales	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_317801_1	1049564.TevJSym_ac01150	1.28e-24	103.0	COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,1J51N@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane	lapB	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008653,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1903509	-	ko:K19804	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_19,TPR_7,TPR_8
k59_493550_1	880073.Calab_1044	0.000168	49.7	COG0421@1|root,COG0421@2|Bacteria,2NNTV@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
k59_1784102_1	580332.Slit_2117	6.87e-94	287.0	COG0475@1|root,COG0475@2|Bacteria,1PK6U@1224|Proteobacteria,2WAEY@28216|Betaproteobacteria,44WJS@713636|Nitrosomonadales	28216|Betaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_1327452_1	2340.JV46_15700	7.46e-76	251.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1J56C@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_317811_1	1085623.GNIT_1040	1.11e-62	202.0	COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,1RPS3@1236|Gammaproteobacteria,4656V@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_1668752_1	265072.Mfla_0381	4.76e-41	139.0	COG0346@1|root,COG0346@2|Bacteria,1RIR2@1224|Proteobacteria,2W7ZA@28216|Betaproteobacteria,2KMVH@206350|Nitrosomonadales	206350|Nitrosomonadales	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_1668752_2	765912.Thimo_1180	3.4e-55	180.0	COG1586@1|root,COG1586@2|Bacteria,1MXPT@1224|Proteobacteria,1RQSX@1236|Gammaproteobacteria,1WX2Z@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speD	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
k59_610843_1	318424.EU78_28820	2.67e-23	94.4	2A9J7@1|root,30YRK@2|Bacteria,2IRV7@201174|Actinobacteria,23F46@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2384)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2384
k59_670038_1	557598.LHK_00749	9.41e-31	115.0	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,2VQ49@28216|Betaproteobacteria,2KQEH@206351|Neisseriales	206351|Neisseriales	E	D,D-heptose 1,7-bisphosphate phosphatase	gmhB	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
k59_670038_2	768671.ThimaDRAFT_2582	2.23e-23	98.2	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1WXP3@135613|Chromatiales	135613|Chromatiales	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_434794_1	1265313.HRUBRA_01475	8.32e-91	273.0	COG0746@1|root,COG0746@2|Bacteria,1QWF1@1224|Proteobacteria,1T603@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	MobA-like NTP transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
k59_670044_1	1249627.D779_3493	1.44e-116	348.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1WWIH@135613|Chromatiales	135613|Chromatiales	CP	PFAM NADH Ubiquinone plastoquinone	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
k59_493565_1	396588.Tgr7_0636	9.43e-109	327.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1WWVW@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM cytochrome c oxidase accessory protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
k59_1549714_1	1127134.NOCYR_2828	0.0004	45.4	COG1680@1|root,COG1680@2|Bacteria,2GNNF@201174|Actinobacteria,4FWAW@85025|Nocardiaceae	201174|Actinobacteria	V	Domain of unknown function (DUF3471)	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
k59_1549714_2	1210046.B277_14533	3.86e-23	100.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria,4FEFR@85021|Intrasporangiaceae	201174|Actinobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_1497778_1	1121405.dsmv_1666	2.26e-113	357.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,2MMPS@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	actB	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1327500_1	765911.Thivi_1064	9.33e-89	291.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon
k59_387931_1	1267005.KB911259_gene3759	1.79e-92	277.0	COG0616@1|root,COG0616@2|Bacteria,1MY1I@1224|Proteobacteria,2U07G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	OU	Serine dehydrogenase proteinase	-	-	-	-	-	-	-	-	-	-	-	-	SDH_sah
k59_552222_1	864069.MicloDRAFT_00001260	7.89e-225	630.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U28T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1
k59_975297_1	1132836.RCCGE510_22074	3.41e-151	439.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2U1EH@28211|Alphaproteobacteria,4BMJ6@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
k59_1668782_1	396588.Tgr7_0945	1.87e-23	107.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1WWAA@135613|Chromatiales	135613|Chromatiales	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,SurA_N_3
k59_1607865_1	224911.27356437	2.06e-74	229.0	COG3832@1|root,COG3832@2|Bacteria,1RDAM@1224|Proteobacteria,2U5ZG@28211|Alphaproteobacteria,3JY1T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
k59_434814_1	396014.BF93_05790	1.17e-32	123.0	2AW24@1|root,31MWV@2|Bacteria,2INRH@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_94435_1	1122218.KB893653_gene1129	1.33e-26	113.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2TRKK@28211|Alphaproteobacteria,1JT49@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	PFAM MscS Mechanosensitive ion channel	kefA	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	DUF3772,MS_channel
k59_783516_1	1123073.KB899241_gene2273	3.35e-30	112.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,1S61A@1236|Gammaproteobacteria,1X6H1@135614|Xanthomonadales	135614|Xanthomonadales	S	Glutamyl-tRNA amidotransferase	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
k59_783516_2	1122134.KB893650_gene782	1.23e-15	75.9	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1XHNC@135619|Oceanospirillales	135619|Oceanospirillales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_1433937_1	765911.Thivi_1519	6.04e-136	405.0	COG0433@1|root,COG0433@2|Bacteria,1QUPX@1224|Proteobacteria,1T20D@1236|Gammaproteobacteria,1WW0J@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM conjugative coupling factor TraD, SXT TOL subfamily	-	-	-	ko:K12071	-	-	-	-	ko00000,ko02044	3.A.7.11.1	-	-	TraG-D_C,TrwB_AAD_bind
k59_317855_1	367299.JOEE01000004_gene1362	9.28e-77	241.0	COG0707@1|root,COG0707@2|Bacteria,2GJEM@201174|Actinobacteria,4FEZH@85021|Intrasporangiaceae	201174|Actinobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227,6.3.2.8	ko:K01924,ko:K02563	ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112	-	R03193,R05032,R05662	RC00005,RC00049,RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_493596_1	1042375.AFPL01000046_gene1797	6.44e-173	500.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,464KP@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_1726288_1	1049564.TevJSym_bb00040	6.92e-63	203.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,1RZ7Y@1236|Gammaproteobacteria,1J5GQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_1726288_2	1049564.TevJSym_bb00030	6.82e-28	114.0	COG1013@1|root,COG1013@2|Bacteria,1R28U@1224|Proteobacteria	1224|Proteobacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
k59_317857_1	717785.HYPMC_2060	3.48e-59	195.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2TR76@28211|Alphaproteobacteria,3N79Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	permease YjgP YjgQ	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_94452_1	1122132.AQYH01000002_gene1283	1.1e-88	278.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria,4BAGU@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_552244_1	1288826.MSNKSG1_00126	1.31e-74	235.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,465NF@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105	Glycos_transf_4,MraY_sig1
k59_94463_1	1168065.DOK_05245	3.69e-94	285.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,1J946@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_317864_1	472759.Nhal_3943	1.88e-70	231.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1WW41@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_1549748_1	1121438.JNJA01000002_gene3434	1.26e-09	59.7	COG2204@1|root,COG3852@1|root,COG2204@2|Bacteria,COG3852@2|Bacteria,1R8G5@1224|Proteobacteria,42QJD@68525|delta/epsilon subdivisions,2WJT3@28221|Deltaproteobacteria,2M8A7@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HisKA,PAS_3,Response_reg
k59_94464_1	1158610.UC3_03003	4.25e-56	189.0	COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes,4H9KU@91061|Bacilli,4AZEB@81852|Enterococcaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21,3.2.1.86	ko:K01223,ko:K05350	ko00010,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00460,map00500,map00940,map01100,map01110	-	R00026,R00839,R02558,R02887,R02985,R03527,R04949,R04998,R05133,R05134,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GT1	-	Glyco_hydro_1
k59_1198909_1	765912.Thimo_0973	2.91e-107	321.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1WW43@135613|Chromatiales	135613|Chromatiales	J	TIGRFAM Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_975344_1	926550.CLDAP_31080	4.53e-74	248.0	COG0849@1|root,COG5012@1|root,COG0849@2|Bacteria,COG5012@2|Bacteria,2G66F@200795|Chloroflexi	200795|Chloroflexi	D	cobalamin binding	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding
k59_783530_1	102232.GLO73106DRAFT_00012360	1.75e-55	182.0	COG3335@1|root,COG3335@2|Bacteria,1G53U@1117|Cyanobacteria	1117|Cyanobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_33
k59_975345_2	713586.KB900536_gene42	3.34e-28	112.0	COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,1TK7U@1236|Gammaproteobacteria,1X089@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8
k59_141861_1	765913.ThidrDRAFT_2548	3.25e-108	329.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1WXDC@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM Asparagine synthase family amidotransferase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_916291_1	765913.ThidrDRAFT_3943	1.22e-28	113.0	COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,1RMZV@1236|Gammaproteobacteria,1X2SU@135613|Chromatiales	135613|Chromatiales	O	OsmC-like protein	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Hydrolase_4,OsmC
k59_916291_2	1500897.JQNA01000002_gene2688	1.68e-43	147.0	COG3837@1|root,COG3837@2|Bacteria,1N15Q@1224|Proteobacteria,2VTYS@28216|Betaproteobacteria,1K8JK@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_493613_1	1304880.JAGB01000004_gene1490	4.7e-60	204.0	COG2801@1|root,COG2801@2|Bacteria,1TT8V@1239|Firmicutes,24BFH@186801|Clostridia	186801|Clostridia	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_32,rve
k59_200428_2	519989.ECTPHS_00500	5.1e-40	147.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,1RPKA@1236|Gammaproteobacteria,1WXPP@135613|Chromatiales	135613|Chromatiales	G	pfam mofrl	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
k59_728595_1	1249627.D779_1262	2.88e-19	87.8	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,1RQPH@1236|Gammaproteobacteria,1WX21@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_1549763_1	261292.Nit79A3_3464	1.52e-75	253.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2VJSI@28216|Betaproteobacteria,372PZ@32003|Nitrosomonadales	28216|Betaproteobacteria	L	RNA polymerase recycling family C-terminal	-	-	-	ko:K03580	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	DUF3883,Helicase_C,RapA_C,ResIII,SNF2_N
k59_1855870_1	383372.Rcas_3954	2.23e-132	388.0	COG0530@1|root,COG0530@2|Bacteria,2G6GV@200795|Chloroflexi,376V8@32061|Chloroflexia	32061|Chloroflexia	P	PFAM sodium calcium exchanger membrane region	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_1497829_1	1082933.MEA186_30901	2.09e-44	167.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_493625_1	1121335.Clst_1812	2.93e-08	57.4	COG1012@1|root,COG1454@1|root,COG1012@2|Bacteria,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,3WHK1@541000|Ruminococcaceae	186801|Clostridia	C	belongs to the iron- containing alcohol dehydrogenase family	adhE	-	1.1.1.1,1.2.1.10	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	-	R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh,Fe-ADH
k59_388024_1	519989.ECTPHS_11497	1.83e-133	397.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1WWE5@135613|Chromatiales	135613|Chromatiales	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_388024_3	1123368.AUIS01000006_gene590	7.02e-65	204.0	2BKU0@1|root,32FA8@2|Bacteria,1RJX5@1224|Proteobacteria,1SJ45@1236|Gammaproteobacteria,2NCXG@225057|Acidithiobacillales	225057|Acidithiobacillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_388024_4	1049564.TevJSym_an00750	2.54e-52	171.0	COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,1J5U7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis	rnt	GO:0000287,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360	-	ko:K03683	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_T
k59_1549769_1	1267005.KB911259_gene4074	8.05e-45	156.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,3N63V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	ko:K21470,ko:K21572	-	-	-	-	ko00000,ko01002,ko01011,ko02000	8.A.46.1,8.A.46.3	-	-	PG_binding_1,YkuD
k59_1549769_2	331869.BAL199_12636	5.91e-155	446.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1433985_1	471853.Bcav_1839	1.32e-55	184.0	COG1228@1|root,COG1228@2|Bacteria,2GJH4@201174|Actinobacteria	201174|Actinobacteria	Q	Catalyzes the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
k59_1433985_2	367299.JOEE01000001_gene1693	1.16e-41	138.0	2DR0Y@1|root,339QH@2|Bacteria,2GRBV@201174|Actinobacteria,4FHXB@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF4235)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4235
k59_317897_1	1537917.JU82_05035	2.53e-86	267.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,42MA0@68525|delta/epsilon subdivisions,2YM88@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_1668838_1	399739.Pmen_2541	6.1e-68	216.0	COG3239@1|root,COG3239@2|Bacteria,1MW29@1224|Proteobacteria,1RPHS@1236|Gammaproteobacteria,1YGW9@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	Fatty acid desaturase	alkB	-	1.14.15.3	ko:K00496	ko00071,ko00930,map00071,map00930	-	R01347,R02281,R06945	RC00478	ko00000,ko00001,ko01000	-	-	-	FA_desaturase
k59_1668838_2	264462.Bd2189	3.51e-55	182.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,42M3F@68525|delta/epsilon subdivisions,2MTN0@213481|Bdellovibrionales,2WJ32@28221|Deltaproteobacteria	213481|Bdellovibrionales	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_141891_1	1121447.JONL01000001_gene524	3.3e-51	171.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,42NFH@68525|delta/epsilon subdivisions,2WITT@28221|Deltaproteobacteria,2M8DG@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_916338_1	367299.JOEE01000003_gene2878	3.71e-24	102.0	COG1714@1|root,COG1714@2|Bacteria,2HXE4@201174|Actinobacteria,4FGCN@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2510)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510,RDD
k59_552279_1	467661.RKLH11_1968	6.12e-38	145.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2U2E4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_552279_3	1122214.AQWH01000017_gene4611	2.3e-54	185.0	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2TSRB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	4,5-dihydroxyphthalate decarboxylase	-	-	4.1.1.55	ko:K04102	ko00624,ko01100,ko01120,map00624,map01100,map01120	M00623	R01635,R05375	RC00390	ko00000,ko00001,ko00002,ko01000	-	-	-	NMT1
k59_317902_1	717785.HYPMC_0017	3.47e-46	157.0	COG5321@1|root,COG5321@2|Bacteria,1RDXW@1224|Proteobacteria,2U73Y@28211|Alphaproteobacteria,3N73Q@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	DNA repair protein MmcB-like	MA20_23405	-	-	-	-	-	-	-	-	-	-	-	MmcB-like
k59_1855907_1	288000.BBta_0450	2.4e-188	529.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,2TSAD@28211|Alphaproteobacteria,3JS5T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Function of homologous gene experimentally demonstrated in an other organism	cbbA	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
k59_272115_1	404589.Anae109_3497	4.33e-14	68.2	COG3123@1|root,COG3123@2|Bacteria,1MZ8N@1224|Proteobacteria,42TQH@68525|delta/epsilon subdivisions,2WQ2M@28221|Deltaproteobacteria,2Z1K8@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions	ppnP	-	2.4.2.1,2.4.2.2	ko:K09913	ko00230,ko00240,map00230,map00240	-	R01561,R01570,R01863,R01876,R02147,R02296,R02297	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	DUF1255
k59_272115_2	443144.GM21_3793	2.74e-26	97.8	COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,42V6T@68525|delta/epsilon subdivisions,2WRAX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
k59_501562_1	765912.Thimo_3515	1.45e-118	355.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,1WWCY@135613|Chromatiales	135613|Chromatiales	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_1734174_1	335543.Sfum_3117	4.43e-33	134.0	COG4258@1|root,COG4258@2|Bacteria,1QX46@1224|Proteobacteria,42QK9@68525|delta/epsilon subdivisions,2WKGH@28221|Deltaproteobacteria,2MSHC@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_1272557_1	313628.LNTAR_04636	8.31e-62	214.0	COG0046@1|root,COG0046@2|Bacteria	2|Bacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,iJN746.PP_1037,ic_1306.c3080	AIRS,AIRS_C,GATase_5
k59_560164_1	1246995.AFR_31675	3.37e-52	175.0	COG0627@1|root,COG0627@2|Bacteria,2GJX4@201174|Actinobacteria,4D9HJ@85008|Micromonosporales	201174|Actinobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_618792_1	697282.Mettu_0116	4.53e-51	179.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria,1XFV4@135618|Methylococcales	135618|Methylococcales	P	Na+/Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans
k59_501566_1	1379270.AUXF01000002_gene1168	5.15e-26	102.0	COG1595@1|root,COG1595@2|Bacteria,1ZT2V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1272560_1	443144.GM21_2462	1.81e-06	54.3	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
k59_1791038_2	1218084.BBJK01000145_gene7429	6.6e-17	81.3	COG1309@1|root,COG1309@2|Bacteria,1RJV4@1224|Proteobacteria,2VSIC@28216|Betaproteobacteria,1K2AV@119060|Burkholderiaceae	28216|Betaproteobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_50336_1	1121405.dsmv_2939	2.9e-41	145.0	COG2214@1|root,COG2214@2|Bacteria,1NW19@1224|Proteobacteria,43012@68525|delta/epsilon subdivisions,2WVBG@28221|Deltaproteobacteria,2MNIU@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM heat shock protein DnaJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1025041_1	909613.UO65_0516	3.46e-42	162.0	COG1196@1|root,COG1196@2|Bacteria,2GK6F@201174|Actinobacteria,4DYJA@85010|Pseudonocardiales	201174|Actinobacteria	D	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	SbcCD_C
k59_930012_1	105559.Nwat_1216	1.7e-27	101.0	COG2119@1|root,COG2119@2|Bacteria,1N85A@1224|Proteobacteria,1SAAX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
k59_930012_2	1123400.KB904769_gene2758	7.82e-07	54.7	COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,1RPW5@1236|Gammaproteobacteria,46151@72273|Thiotrichales	72273|Thiotrichales	H	PFAM UbiA prenyltransferase	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_989176_2	765912.Thimo_1350	1.25e-05	47.8	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1RZEA@1236|Gammaproteobacteria,1WWTV@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM Cytochrome c-type biogenesis protein CcmI	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_2
k59_325832_1	396588.Tgr7_2901	2.98e-30	123.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1X29W@135613|Chromatiales	135613|Chromatiales	NT	chemotaxis	-	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	MCPsignal,PilJ
k59_1272567_2	471853.Bcav_1364	7.49e-57	189.0	COG0620@1|root,COG0620@2|Bacteria,2GMPS@201174|Actinobacteria	201174|Actinobacteria	E	Methionine synthase	-	-	-	-	-	-	-	-	-	-	-	-	Meth_synt_2
k59_1557733_1	497321.C664_02180	1.13e-29	110.0	COG0680@1|root,COG0680@2|Bacteria,1MZE1@1224|Proteobacteria,2VTPX@28216|Betaproteobacteria,2KWJ7@206389|Rhodocyclales	206389|Rhodocyclales	C	maturation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1557733_2	1163617.SCD_n01600	1.09e-63	208.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,2VJT0@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hoxH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
k59_1272569_1	877424.ATWC01000007_gene183	3.21e-58	196.0	COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia,27IEF@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_1143755_1	1528106.JRJE01000006_gene1173	1.03e-16	79.0	COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,2TW0S@28211|Alphaproteobacteria,2JTTA@204441|Rhodospirillales	204441|Rhodospirillales	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_989201_1	909943.HIMB100_00007300	2.38e-98	298.0	COG1679@1|root,COG1679@2|Bacteria,1NFH4@1224|Proteobacteria,2TTR6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
k59_790138_1	765913.ThidrDRAFT_2614	1.3e-138	417.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1WXPB@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_108150_1	471875.RUMLAC_00087	1.24e-15	81.6	COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,3WGJN@541000|Ruminococcaceae	186801|Clostridia	L	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity	polC	-	2.7.7.7	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
k59_150140_1	935557.ATYB01000008_gene4833	6.08e-05	45.4	COG2267@1|root,COG2303@1|root,COG3540@1|root,COG2267@2|Bacteria,COG2303@2|Bacteria,COG3540@2|Bacteria,1QQ8F@1224|Proteobacteria,2U7D4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EI	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_150140_2	269796.Rru_A3756	2.33e-25	107.0	COG0642@1|root,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,2JR29@204441|Rhodospirillales	204441|Rhodospirillales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HATPase_c,HisKA,PAS_4,PAS_7,Response_reg
k59_1272581_1	292415.Tbd_1078	2.21e-160	469.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2VHHJ@28216|Betaproteobacteria,1KRBU@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Hsp90 protein	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
k59_1441963_1	754476.Q7A_1931	1.14e-86	287.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,4609J@72273|Thiotrichales	72273|Thiotrichales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_402853_1	95619.PM1_0211680	4.42e-46	159.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	GO:0003674,GO:0003824,GO:0004149,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008289,GO:0009060,GO:0009987,GO:0015980,GO:0016417,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016751,GO:0016999,GO:0017144,GO:0019752,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:0140096,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1352,iECED1_1282.ECED1_0696,iECOK1_1307.ECOK1_0726,iECS88_1305.ECS88_0752,iLF82_1304.LF82_2196,iNRG857_1313.NRG857_03235,iUMN146_1321.UM146_13990,iUTI89_1310.UTI89_C0722	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_402853_2	1177179.A11A3_06305	1.58e-35	132.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1XH5E@135619|Oceanospirillales	135619|Oceanospirillales	C	2-oxoglutarate dehydrogenase complex	lpdG	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1273463_1	472759.Nhal_3175	8.03e-45	155.0	COG1397@1|root,COG1397@2|Bacteria,1PMP6@1224|Proteobacteria,1TK5S@1236|Gammaproteobacteria,1WZKE@135613|Chromatiales	135613|Chromatiales	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
k59_1507821_2	1348635.BBJY01000004_gene2955	2.57e-07	56.6	COG2067@1|root,COG2067@2|Bacteria,1R3SS@1224|Proteobacteria,1S0X2@1236|Gammaproteobacteria,1XUNF@135623|Vibrionales	135623|Vibrionales	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_1735058_1	396588.Tgr7_0895	1.93e-63	213.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1WWKZ@135613|Chromatiales	135613|Chromatiales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_1735058_2	143224.JQMD01000002_gene3159	3e-05	48.5	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,4NEKW@976|Bacteroidetes,1HYXP@117743|Flavobacteriia	976|Bacteroidetes	M	Lytic murein transglycosylase	mltD	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_1098987_2	387093.SUN_2366	7.5e-39	138.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,42QAC@68525|delta/epsilon subdivisions,2YNGY@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_402860_1	765914.ThisiDRAFT_0771	1.4e-08	57.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales	135613|Chromatiales	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_402860_2	1122236.KB905145_gene2421	9.33e-68	213.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,2VI54@28216|Betaproteobacteria,2KKGV@206350|Nitrosomonadales	206350|Nitrosomonadales	Q	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_619662_1	1410676.JNKL01000010_gene2065	0.00053	42.7	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,1S3NR@1236|Gammaproteobacteria,1Y4FV@135624|Aeromonadales	135624|Aeromonadales	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
k59_402861_1	476272.RUMHYD_00332	4.49e-84	268.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,3XZ6P@572511|Blautia	186801|Clostridia	C	Psort location Cytoplasmic, score 9.98	hymB	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00335,ko:K18331,ko:K22339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_1791787_1	1449069.JMLO01000015_gene621	4.85e-235	665.0	COG0507@1|root,COG3410@1|root,COG0507@2|Bacteria,COG3410@2|Bacteria,2HNSJ@201174|Actinobacteria,4FWM8@85025|Nocardiaceae	201174|Actinobacteria	L	Uncharacterized conserved protein (DUF2075)	-	-	-	ko:K09384	-	-	-	-	ko00000	-	-	-	DUF2075
k59_790810_1	1096930.L284_09155	5.72e-32	115.0	COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria,2K3Y6@204457|Sphingomonadales	204457|Sphingomonadales	L	COG2963 Transposase and inactivated derivatives	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_284056_1	765914.ThisiDRAFT_1142	4.42e-202	572.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1WWC9@135613|Chromatiales	135613|Chromatiales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_931247_1	1408433.JHXV01000011_gene2086	6.83e-06	53.5	COG0457@1|root,COG2207@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2207@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IFYH@117743|Flavobacteriia,2PBJW@246874|Cryomorphaceae	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,Guanylate_cyc,HTH_18,TPR_8
k59_854881_1	877455.Metbo_0556	7.2e-27	110.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,23NQ3@183925|Methanobacteria	183925|Methanobacteria	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_854881_2	28042.GU90_12460	3.53e-25	100.0	COG1371@1|root,COG1371@2|Bacteria,2IS0V@201174|Actinobacteria,4E6HK@85010|Pseudonocardiales	201174|Actinobacteria	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
k59_854881_3	1120950.KB892708_gene4507	7.92e-35	128.0	COG1515@1|root,COG1515@2|Bacteria,2GJEZ@201174|Actinobacteria,4DUVR@85009|Propionibacteriales	201174|Actinobacteria	L	Endonuclease V	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
k59_1382894_1	1254432.SCE1572_38930	3.07e-32	120.0	COG2322@1|root,COG2322@2|Bacteria,1N3YI@1224|Proteobacteria,430G9@68525|delta/epsilon subdivisions,2WVW0@28221|Deltaproteobacteria,2YV26@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF420)	-	-	-	ko:K08976	-	-	-	-	ko00000	-	-	-	DUF420
k59_1382894_2	596154.Alide2_3903	6.09e-151	445.0	COG0843@1|root,COG0843@2|Bacteria,1QJ23@1224|Proteobacteria,2VKFW@28216|Betaproteobacteria,4AH9U@80864|Comamonadaceae	28216|Betaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	-	-	-	-	-	-	-	-	-	-	COX1
k59_1207642_1	28258.KP05_01225	1.33e-17	82.4	COG0128@1|root,COG0287@1|root,COG0128@2|Bacteria,COG0287@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1XIJ8@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	1.3.1.12,2.5.1.19	ko:K00210,ko:K00800	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00022,M00025	R01728,R03460	RC00125,RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase,PDH
k59_1207642_2	1523503.JPMY01000036_gene1543	1.5e-75	234.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,1RNKT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO1391,iSDY_1059.SDY_2348	Cytidylate_kin
k59_1207642_3	631362.Thi970DRAFT_04679	4.16e-06	47.8	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1WVVK@135613|Chromatiales	135613|Chromatiales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_402873_1	1459636.NTE_02178	1.64e-68	225.0	COG0028@1|root,arCOG01998@2157|Archaea,41S63@651137|Thaumarchaeota	651137|Thaumarchaeota	E	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1558681_1	1385520.N802_07865	4.26e-59	205.0	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4FFTS@85021|Intrasporangiaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 65, C-terminal domain	-	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
k59_284071_1	1304865.JAGF01000001_gene1665	7.99e-11	63.5	COG3976@1|root,COG3976@2|Bacteria,2GTTI@201174|Actinobacteria	201174|Actinobacteria	S	FMN-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
k59_1616948_1	1144312.PMI09_01001	4.24e-24	103.0	COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,2TS12@28211|Alphaproteobacteria,4B9E2@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	prephenate dehydrogenase	tyrC	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.3.1.12,1.3.1.43	ko:K00210,ko:K00220,ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025,M00040	R00732,R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
k59_1677813_1	367299.JOEE01000004_gene1417	1.24e-135	391.0	COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,4FEBS@85021|Intrasporangiaceae	201174|Actinobacteria	E	glycine cleavage system	gcvT	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_790826_1	292564.Cyagr_0049	1.13e-56	197.0	COG0028@1|root,COG0028@2|Bacteria,1G17K@1117|Cyanobacteria,22RZI@167375|Cyanobium	1117|Cyanobacteria	H	EH COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N,zinc_ribbon_2
k59_1273487_1	323261.Noc_2397	4.74e-129	381.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,1WWYU@135613|Chromatiales	135613|Chromatiales	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
k59_1342691_1	331869.BAL199_22737	3.37e-07	49.3	29U1D@1|root,30FAK@2|Bacteria,1RCY2@1224|Proteobacteria,2UF0W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1735088_1	857087.Metme_2755	7.79e-80	252.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1XDRQ@135618|Methylococcales	135618|Methylococcales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_1099009_1	935839.JAGJ01000002_gene683	5.09e-63	213.0	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4F4N0@85017|Promicromonosporaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 65, C-terminal domain	-	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
k59_1099009_2	1043493.BBLU01000004_gene2724	2.06e-54	179.0	COG0637@1|root,COG0637@2|Bacteria,2I2IT@201174|Actinobacteria	201174|Actinobacteria	G	Beta-phosphoglucomutase family hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Hydrolase
k59_1507857_1	439235.Dalk_3005	7.86e-42	143.0	COG1633@1|root,COG1633@2|Bacteria,1N4PW@1224|Proteobacteria,42UZG@68525|delta/epsilon subdivisions,2WNGQ@28221|Deltaproteobacteria,2MJYE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
k59_284086_1	1286632.P278_21990	5.08e-75	247.0	COG3808@1|root,COG3808@2|Bacteria,4NF2I@976|Bacteroidetes,1HWN8@117743|Flavobacteriia	976|Bacteroidetes	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase,OmpA
k59_1342703_1	1123371.ATXH01000006_gene891	3.19e-05	48.5	COG0628@1|root,COG0628@2|Bacteria,2GHCK@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1342703_2	640081.Dsui_2387	1.1e-46	159.0	COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,2VRE4@28216|Betaproteobacteria,2KWM9@206389|Rhodocyclales	206389|Rhodocyclales	S	AMMECR1	-	-	-	-	-	-	-	-	-	-	-	-	AMMECR1
k59_1342703_3	1121935.AQXX01000141_gene2046	4.44e-30	114.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,1RQPK@1236|Gammaproteobacteria,1XJIC@135619|Oceanospirillales	135619|Oceanospirillales	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
k59_790834_1	335543.Sfum_0091	9.69e-72	221.0	COG4117@1|root,COG4117@2|Bacteria,1R5GN@1224|Proteobacteria,42QVP@68525|delta/epsilon subdivisions,2WMT7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM cytochrome B561	cbcB	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_990495_1	207559.Dde_1858	3.03e-138	397.0	COG1715@1|root,COG1715@2|Bacteria,1R4NQ@1224|Proteobacteria,43B1F@68525|delta/epsilon subdivisions,2X6FN@28221|Deltaproteobacteria,2MH2I@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	HB1, ASXL, restriction endonuclease HTH domain	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	HARE-HTH,Mrr_cat
k59_1616970_1	1502852.FG94_00890	1.78e-25	110.0	COG0515@1|root,COG2199@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,1R7HC@1224|Proteobacteria,2WGMD@28216|Betaproteobacteria,4791R@75682|Oxalobacteraceae	28216|Betaproteobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GGDEF,Pkinase
k59_1273504_2	357804.Ping_0701	2.59e-21	93.6	COG4902@1|root,COG4902@2|Bacteria,1RHUF@1224|Proteobacteria,1S5D0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein domain (DUF2202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2202
k59_109389_1	472759.Nhal_0530	3.51e-99	317.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,1WWQ3@135613|Chromatiales	135613|Chromatiales	S	DNA internalization-related competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_109389_2	765914.ThisiDRAFT_0926	2.81e-93	278.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1WX5A@135613|Chromatiales	135613|Chromatiales	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_109389_3	1045855.DSC_09085	3.72e-34	123.0	COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,1S90K@1236|Gammaproteobacteria,1X6SD@135614|Xanthomonadales	135614|Xanthomonadales	U	Biopolymer	exbD4	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_1870940_1	572477.Alvin_1266	5e-75	233.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1WWB3@135613|Chromatiales	135613|Chromatiales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_1870940_2	765912.Thimo_2125	2.61e-19	82.0	2E189@1|root,32WNT@2|Bacteria,1N4GY@1224|Proteobacteria,1SBNR@1236|Gammaproteobacteria,1WZFT@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_402921_1	745014.OMB55_00006520	1.97e-116	343.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,1RNJH@1236|Gammaproteobacteria,1J59W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	COG1960 Acyl-CoA dehydrogenases	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1616978_1	414684.RC1_3377	2.24e-52	179.0	COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,2TUE5@28211|Alphaproteobacteria,2JPSJ@204441|Rhodospirillales	204441|Rhodospirillales	S	Sodium:neurotransmitter symporter family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_1144556_1	1123487.KB892863_gene1923	4.1e-16	77.8	2AJXH@1|root,31AKJ@2|Bacteria,1RJPF@1224|Proteobacteria,2VTF5@28216|Betaproteobacteria,2KWU0@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain of unknown function (DUF4149)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4149
k59_1144556_2	1038869.AXAN01000031_gene517	2.38e-18	82.0	COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,2VVP0@28216|Betaproteobacteria,1K760@119060|Burkholderiaceae	28216|Betaproteobacteria	J	RNA-binding protein	yhbY	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
k59_1273511_1	266940.Krad_3013	2.38e-50	170.0	COG0337@1|root,COG0337@2|Bacteria,2GIUZ@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
k59_1273511_2	593907.Celgi_1795	1.74e-55	176.0	COG0757@1|root,COG0757@2|Bacteria,2IMBY@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	GO:0003674,GO:0003824,GO:0003855,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901576	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
k59_209541_1	246197.MXAN_5499	0.00042	50.4	COG0457@1|root,COG0457@2|Bacteria,1PEH7@1224|Proteobacteria,42TVC@68525|delta/epsilon subdivisions,2WSUQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8
k59_748148_1	1122236.KB905146_gene1896	1.2e-56	185.0	COG1305@1|root,COG1305@2|Bacteria,1MVAG@1224|Proteobacteria,2VMU5@28216|Betaproteobacteria,2KNMV@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_571151_1	1121405.dsmv_0971	1.32e-99	304.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2MHS6@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_337439_1	765913.ThidrDRAFT_1739	1.67e-37	128.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,1S8VX@1236|Gammaproteobacteria,1WYZN@135613|Chromatiales	135613|Chromatiales	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_337439_2	717773.Thicy_0125	1.06e-29	112.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,1RMGR@1236|Gammaproteobacteria,45ZZI@72273|Thiotrichales	72273|Thiotrichales	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_1453059_1	439235.Dalk_1921	3.97e-73	246.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2MI5C@213118|Desulfobacterales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1392870_1	1123392.AQWL01000006_gene639	1.47e-14	73.6	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1KSIU@119069|Hydrogenophilales	119069|Hydrogenophilales	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1392870_2	1144342.PMI40_04223	1.5e-15	80.5	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VHTK@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k59_865135_1	631362.Thi970DRAFT_03247	2.76e-39	143.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1WWQM@135613|Chromatiales	135613|Chromatiales	P	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1800602_1	1121935.AQXX01000142_gene2322	5.35e-20	82.4	2E588@1|root,3300P@2|Bacteria,1N79I@1224|Proteobacteria,1SCYA@1236|Gammaproteobacteria,1XM1Y@135619|Oceanospirillales	135619|Oceanospirillales	S	Domain of unknown function (DUF5062)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5062
k59_1800602_2	105559.Nwat_2043	6.73e-18	85.5	COG0412@1|root,COG0412@2|Bacteria,1QW3K@1224|Proteobacteria,1S38F@1236|Gammaproteobacteria,1X0ND@135613|Chromatiales	135613|Chromatiales	Q	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_798704_2	1385520.N802_00940	2.36e-89	289.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,4FEFA@85021|Intrasporangiaceae	201174|Actinobacteria	D	Cell division protein FtsK	ftsK	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1745730_1	880072.Desac_2573	3.97e-92	275.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,42QQE@68525|delta/epsilon subdivisions,2WNC3@28221|Deltaproteobacteria,2MRKJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_1688023_1	1049564.TevJSym_ab00440	0.0	905.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J8SM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Citrate transporter	sac1	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_1688023_2	1123368.AUIS01000005_gene483	2.7e-15	75.1	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,2NBWP@225057|Acidithiobacillales	225057|Acidithiobacillales	C	4Fe-4S dicluster domain	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7
k59_1153642_1	648757.Rvan_3260	4.15e-05	48.5	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2TRW2@28211|Alphaproteobacteria,3N67K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_1153642_2	696369.KI912183_gene2000	1.69e-26	105.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,26093@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, C-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_689349_1	765911.Thivi_3195	2.14e-48	163.0	29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,1SBT1@1236|Gammaproteobacteria,1WYAZ@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4390)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4390
k59_689349_2	765912.Thimo_1245	2.3e-51	176.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1WVWG@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
k59_512755_1	765914.ThisiDRAFT_1709	2.05e-36	138.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1SYH1@1236|Gammaproteobacteria,1X2II@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_337476_1	159450.NH14_01140	1.14e-60	201.0	COG0369@1|root,COG1145@1|root,COG0369@2|Bacteria,COG1145@2|Bacteria,1NCKQ@1224|Proteobacteria,2VIZE@28216|Betaproteobacteria,1K05A@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Benzoyl-CoA oxygenase	boxA	-	1.14.13.208,1.18.1.2,1.19.1.1	ko:K00528,ko:K02641,ko:K15511	ko00195,ko00362,ko01100,map00195,map00362,map01100	-	R09555,R10159	RC01739	ko00000,ko00001,ko00194,ko01000	-	-	-	FAD_binding_6,Fer4,NAD_binding_1
k59_1745751_1	33178.CADATEAP00007258	7.18e-05	46.6	2E6PU@1|root,2SDCQ@2759|Eukaryota,3A8A2@33154|Opisthokonta,3P7CI@4751|Fungi,3QYXS@4890|Ascomycota	4751|Fungi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1285514_1	1298608.JCM18900_375	1.46e-40	142.0	COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,1RQB7@1236|Gammaproteobacteria,3NR82@468|Moraxellaceae	1236|Gammaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	potC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015399,GO:0015405,GO:0015417,GO:0015595,GO:0015606,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0015848,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098533,GO:0098655,GO:0098796,GO:0098797,GO:1902047,GO:1902494,GO:1902495,GO:1903711,GO:1904949,GO:1990351	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	iSBO_1134.SBO_1939	BPD_transp_1
k59_1285514_2	1122197.ATWI01000010_gene1028	2.86e-96	291.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,1RM7W@1236|Gammaproteobacteria,4654B@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	potD	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0015848,GO:0019808,GO:0019809,GO:0019810,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0051179,GO:0051234,GO:0070405,GO:0071702,GO:0071705	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	iSbBS512_1146.SbBS512_E2202	SBP_bac_6,SBP_bac_8
k59_1519470_1	670487.Ocepr_0931	3.4e-31	124.0	COG0318@1|root,COG0318@2|Bacteria,1WIAG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_1519470_2	1122243.KB903804_gene2096	1.49e-14	72.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,1S3QR@1236|Gammaproteobacteria,3NKT2@468|Moraxellaceae	1236|Gammaproteobacteria	G	Peptidyl-prolyl cis-trans	slyD	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010467,GO:0016151,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022417,GO:0031647,GO:0035821,GO:0036211,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043963,GO:0044003,GO:0044068,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044501,GO:0046872,GO:0046914,GO:0050821,GO:0050896,GO:0050897,GO:0051082,GO:0051604,GO:0051701,GO:0051704,GO:0051817,GO:0052027,GO:0052250,GO:0065007,GO:0065008,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
k59_454009_1	1095767.CAHD01000006_gene2179	7.33e-80	260.0	COG1109@1|root,COG1109@2|Bacteria,2GJ3Q@201174|Actinobacteria,4F0W7@85016|Cellulomonadaceae	201174|Actinobacteria	G	PFAM phosphoglucomutase phosphomannomutase alpha beta alpha domain I	pmmB	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_454009_2	1176165.CAJD01000023_gene1952	0.000159	43.5	COG0005@1|root,COG0005@2|Bacteria,2GKEI@201174|Actinobacteria,4F8I9@85019|Brevibacteriaceae	201174|Actinobacteria	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	GO:0003674,GO:0003824,GO:0004731,GO:0006139,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009120,GO:0009164,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046121,GO:0046122,GO:0046124,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
k59_1037149_1	471852.Tcur_4848	6.7e-62	198.0	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,4EG20@85012|Streptosporangiales	201174|Actinobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_1568833_1	1116472.MGMO_53c00440	2.71e-61	204.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,1XEKR@135618|Methylococcales	135618|Methylococcales	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_337494_1	1125863.JAFN01000001_gene2424	1.69e-37	138.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,42QE5@68525|delta/epsilon subdivisions,2WM8R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
k59_1285538_1	580332.Slit_2074	1.38e-38	138.0	COG0676@1|root,COG0676@2|Bacteria,1Q7VN@1224|Proteobacteria,2VKZK@28216|Betaproteobacteria,44V5J@713636|Nitrosomonadales	28216|Betaproteobacteria	G	Belongs to the glucose-6-phosphate 1-epimerase family	-	-	5.1.3.15	ko:K01792	ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130	-	R02739	RC00563	ko00000,ko00001,ko01000	-	-	-	Aldose_epim
k59_337496_1	367299.JOEE01000001_gene1657	2.41e-80	254.0	COG3573@1|root,COG3573@2|Bacteria,2GIYM@201174|Actinobacteria,4FFER@85021|Intrasporangiaceae	201174|Actinobacteria	S	Proposed role in polysaccahride synthesis	-	-	-	ko:K07077	-	-	-	-	ko00000	-	-	-	FAD_binding_2
k59_630166_2	1123368.AUIS01000005_gene487	4.45e-115	351.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RYC8@1236|Gammaproteobacteria,2NC3Q@225057|Acidithiobacillales	225057|Acidithiobacillales	G	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase	-	-	-	-	-	-	-	-	-	-	-	-	XFP,XFP_N
k59_1285540_1	43759.JNWK01000034_gene3044	2.73e-28	119.0	COG3325@1|root,COG3469@1|root,COG3325@2|Bacteria,COG3469@2|Bacteria,2GJGW@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 18 family	chtA	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	CBM_2,Glyco_hydro_18,fn3
k59_1217794_1	272630.MexAM1_META1p3547	1.02e-05	46.6	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2TQW9@28211|Alphaproteobacteria,1JTRA@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM Cys Met metabolism	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1217794_2	768671.ThimaDRAFT_4004	1.4e-115	339.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,1RVJU@1236|Gammaproteobacteria,1WXJS@135613|Chromatiales	135613|Chromatiales	I	Poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009058,GO:0016234,GO:0042618,GO:0042619,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0070088,GO:0071704,GO:1901440,GO:1901441,GO:1901576	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_1285561_1	1123401.JHYQ01000022_gene1120	3.9e-76	243.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,45ZXR@72273|Thiotrichales	72273|Thiotrichales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_512795_1	998674.ATTE01000001_gene2015	1.01e-47	172.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,46039@72273|Thiotrichales	72273|Thiotrichales	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)	-	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
k59_1110764_1	472759.Nhal_0795	2.29e-21	98.2	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1WWAA@135613|Chromatiales	135613|Chromatiales	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,SurA_N_3
k59_1285578_1	187272.Mlg_1964	1.08e-67	233.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM NADH-quinone oxidoreductase, chain G	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1285578_2	545276.KB898724_gene1866	2.82e-10	60.8	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1WXDH@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_1285581_1	240016.ABIZ01000001_gene292	1.88e-86	286.0	COG0265@1|root,COG0823@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2234@2|Bacteria,46T85@74201|Verrucomicrobia	74201|Verrucomicrobia	OU	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,PD40,PDZ_2,Peptidase_M28
k59_1519536_1	1323361.JPOC01000016_gene1992	1.93e-47	166.0	COG3480@1|root,COG3480@2|Bacteria,2GJDD@201174|Actinobacteria,4FVK4@85025|Nocardiaceae	201174|Actinobacteria	T	Belongs to the peptidase S16 family	lon	-	-	ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	Lon_C,PDZ_2
k59_512812_1	1298863.AUEP01000010_gene4492	3.95e-23	99.0	COG3806@1|root,COG3806@2|Bacteria,2HU8N@201174|Actinobacteria,4DSUX@85009|Propionibacteriales	201174|Actinobacteria	T	Anti-sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
k59_512812_2	1122997.AUDD01000001_gene2432	1.61e-37	134.0	COG1131@1|root,COG1131@2|Bacteria,2GNQJ@201174|Actinobacteria,4DQM7@85009|Propionibacteriales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1745804_3	631362.Thi970DRAFT_00772	1.91e-37	133.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,1S68H@1236|Gammaproteobacteria,1WYKN@135613|Chromatiales	135613|Chromatiales	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
k59_1800684_1	1298863.AUEP01000013_gene4054	6.83e-07	53.1	COG3173@1|root,COG3173@2|Bacteria,2IA48@201174|Actinobacteria,4DR9I@85009|Propionibacteriales	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_631431_1	1049564.TevJSym_ad00270	5.69e-120	361.0	COG1008@1|root,COG1008@2|Bacteria,1R6UV@1224|Proteobacteria,1S0HQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	overlaps another CDS with the same product name	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1689560_1	1267005.KB911258_gene555	2.24e-183	543.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2TQZU@28211|Alphaproteobacteria,3N6ID@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_1570364_2	1385517.N800_13170	7.77e-10	59.7	COG0848@1|root,COG0848@2|Bacteria,1RENY@1224|Proteobacteria,1S3TB@1236|Gammaproteobacteria,1X7V1@135614|Xanthomonadales	135614|Xanthomonadales	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
k59_338915_1	1335757.SPICUR_07975	4.81e-68	218.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,1WWCM@135613|Chromatiales	135613|Chromatiales	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
k59_513867_1	1713.JOFV01000003_gene1421	6.02e-89	292.0	COG0577@1|root,COG0577@2|Bacteria,2GJTZ@201174|Actinobacteria,4F1V7@85016|Cellulomonadaceae	201174|Actinobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_749675_1	323848.Nmul_A0855	2.65e-18	84.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,371UM@32003|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	odhL	GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_749675_2	396588.Tgr7_2113	2.47e-38	147.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WW1G@135613|Chromatiales	135613|Chromatiales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1287101_1	765910.MARPU_07835	4.43e-99	311.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales	135613|Chromatiales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1454685_1	1415778.JQMM01000001_gene1140	5.52e-38	145.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVS@1236|Gammaproteobacteria,1J55S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA
k59_1801868_1	933262.AXAM01000004_gene2398	4.36e-47	170.0	COG0457@1|root,COG0683@1|root,COG0457@2|Bacteria,COG0683@2|Bacteria,1R8IG@1224|Proteobacteria,42N7H@68525|delta/epsilon subdivisions,2WIUQ@28221|Deltaproteobacteria,2MHTC@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Periplasmic binding protein	-	-	-	ko:K07121	-	-	-	-	ko00000	-	-	-	LppC,Peripla_BP_6,TPR_16,TPR_6
k59_1628503_1	1232437.KL662023_gene905	2.61e-21	84.0	COG2835@1|root,COG2835@2|Bacteria,1Q1BG@1224|Proteobacteria,42WTN@68525|delta/epsilon subdivisions,2WSI9@28221|Deltaproteobacteria,2MM3G@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the UPF0434 family	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
k59_1628503_2	880072.Desac_0948	2.57e-34	129.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,43AFG@68525|delta/epsilon subdivisions,2WKA9@28221|Deltaproteobacteria,2MQMK@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	PFAM glycosyl transferase, family 9	-	-	-	ko:K02841	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_1689576_1	443152.MDG893_12363	4.28e-06	50.4	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,4659R@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Lytic murein transglycosylase	mltB	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
k59_1570382_1	880072.Desac_0603	9.02e-49	174.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,2MQXI@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Penicillin-binding Protein dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
k59_220860_2	1353537.TP2_13440	1.36e-58	184.0	COG3255@1|root,COG3255@2|Bacteria,1RI49@1224|Proteobacteria,2UF1P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1454690_1	909663.KI867150_gene1133	7.47e-69	220.0	COG0491@1|root,COG0491@2|Bacteria,1QTGK@1224|Proteobacteria,437XK@68525|delta/epsilon subdivisions,2X37I@28221|Deltaproteobacteria,2MSAK@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_749692_1	526222.Desal_1331	2.19e-65	214.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42ME4@68525|delta/epsilon subdivisions,2WJA5@28221|Deltaproteobacteria,2MA0T@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1454695_2	931627.MycrhDRAFT_2784	3.17e-56	184.0	COG0447@1|root,COG0447@2|Bacteria,2GK5G@201174|Actinobacteria,238F2@1762|Mycobacteriaceae	201174|Actinobacteria	H	enoyl-CoA hydratase isomerase family	menB	-	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_1038798_1	691883.XP_009493824.1	3.22e-78	263.0	COG0265@1|root,KOG1421@2759|Eukaryota,39J7H@33154|Opisthokonta	33154|Opisthokonta	O	serine-type endopeptidase activity	nma111	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0006508,GO:0006629,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009987,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044237,GO:0044238,GO:0044255,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	-	-	-	-	-	-	-	-	-	PDZ_1,PDZ_2,Trypsin_2
k59_338943_1	697282.Mettu_1623	9.2e-207	582.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1XEFM@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1454707_1	96561.Dole_1616	9.68e-25	101.0	COG5401@1|root,COG5401@2|Bacteria,1NA0G@1224|Proteobacteria,42V1V@68525|delta/epsilon subdivisions,2WRCV@28221|Deltaproteobacteria,2MKUK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
k59_1394368_1	1123065.ATWL01000007_gene3309	1.94e-102	308.0	COG0042@1|root,COG0042@2|Bacteria,2GJ8I@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	GO:0008150,GO:0010565,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0080090	-	-	-	-	-	-	-	-	-	-	Dus
k59_1394368_2	593907.Celgi_1263	1.51e-06	51.2	COG0366@1|root,COG0366@2|Bacteria,2GKK1@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	aml	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_20
k59_749705_1	367299.JOEE01000012_gene3272	7.18e-105	317.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4FE9C@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_1112338_1	261292.Nit79A3_2847	1.66e-89	275.0	COG2170@1|root,COG2170@2|Bacteria,1MY35@1224|Proteobacteria,2VNEE@28216|Betaproteobacteria,3743G@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Glutamate-cysteine ligase family 2(GCS2)	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
k59_338958_1	754476.Q7A_92	1.32e-49	173.0	COG1502@1|root,COG1502@2|Bacteria,1MXA6@1224|Proteobacteria,1RZZ7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
k59_338959_1	1123065.ATWL01000005_gene1351	1e-42	153.0	COG0114@1|root,COG0114@2|Bacteria,2GKWY@201174|Actinobacteria	201174|Actinobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_1454723_1	765914.ThisiDRAFT_1947	3.05e-124	392.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1WX8F@135613|Chromatiales	135613|Chromatiales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_1801902_1	314231.FP2506_09781	9.24e-65	218.0	COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,2TRVM@28211|Alphaproteobacteria,2PJ3B@255475|Aurantimonadaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF839)	-	-	-	ko:K07093	-	-	-	-	ko00000	-	-	-	DUF839
k59_220897_1	903814.ELI_4317	3.73e-37	135.0	COG1811@1|root,COG1811@2|Bacteria,1UH19@1239|Firmicutes,24AZ3@186801|Clostridia,25WNA@186806|Eubacteriaceae	186801|Clostridia	S	Protein of unknown function (DUF554)	-	-	-	ko:K07150	-	-	-	-	ko00000	-	-	-	DUF554
k59_643238_1	1249627.D779_0578	8.36e-96	297.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1WX7K@135613|Chromatiales	135613|Chromatiales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_1466851_1	1049564.TevJSym_aa00470	3.74e-247	701.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,1J4KB@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	nirB	-	1.18.1.1,1.7.1.15	ko:K00362,ko:K05297	ko00071,ko00910,ko01120,map00071,map00910,map01120	M00530	R00787,R02000	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Rieske_2
k59_351967_2	153948.NAL212_0950	2.08e-48	171.0	COG1858@1|root,COG1858@2|Bacteria,1QVCJ@1224|Proteobacteria,2WGXR@28216|Betaproteobacteria,373M7@32003|Nitrosomonadales	28216|Betaproteobacteria	C	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1407623_1	1158756.AQXQ01000005_gene250	1.49e-63	206.0	COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,1RMF1@1236|Gammaproteobacteria,1WXIP@135613|Chromatiales	135613|Chromatiales	E	Belongs to the agmatine deiminase family	aguA	-	-	-	-	-	-	-	-	-	-	-	PAD_porph
k59_468603_1	870187.Thini_3774	4.69e-84	271.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,463NI@72273|Thiotrichales	72273|Thiotrichales	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,Pyr_redox_2
k59_703567_2	1072685.IX83_08230	4.49e-13	67.4	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2VHIC@28216|Betaproteobacteria,3T240@506|Alcaligenaceae	28216|Betaproteobacteria	E	COG1126 ABC-type polar amino acid transport system, ATPase component	gltL	-	3.6.3.21	ko:K02028,ko:K10004	ko02010,ko02020,map02010,map02020	M00230,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.19,3.A.1.3.4	-	-	ABC_tran
k59_643269_1	272943.RSP_2125	3.16e-19	82.8	COG5467@1|root,COG5467@2|Bacteria,1MZRN@1224|Proteobacteria,2UC1G@28211|Alphaproteobacteria,1FC6J@1060|Rhodobacter	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1476)	MA20_09035	-	-	-	-	-	-	-	-	-	-	-	DUF1476
k59_1819551_2	1232437.KL661985_gene3573	1.8e-15	73.9	COG1633@1|root,COG1633@2|Bacteria,1N36M@1224|Proteobacteria,42UVX@68525|delta/epsilon subdivisions,2WQ53@28221|Deltaproteobacteria,2MMYP@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
k59_1819602_1	1304865.JAGF01000001_gene1911	1.54e-160	471.0	COG1404@1|root,COG1404@2|Bacteria,2GNIX@201174|Actinobacteria,4F2BU@85016|Cellulomonadaceae	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_815165_1	316067.Geob_1618	1.94e-11	70.5	COG1470@1|root,COG3055@1|root,COG3386@1|root,COG4886@1|root,COG1470@2|Bacteria,COG3055@2|Bacteria,COG3386@2|Bacteria,COG4886@2|Bacteria,1MYQG@1224|Proteobacteria,42P3T@68525|delta/epsilon subdivisions,2WKUC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Galactose oxidase, central domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566,Kelch_1,Kelch_3,Kelch_4,Kelch_6,PKD,REJ
k59_815203_1	926569.ANT_02020	4.6e-112	328.0	COG1788@1|root,COG1788@2|Bacteria,2G6IM@200795|Chloroflexi	200795|Chloroflexi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_815258_1	1123290.AUDQ01000017_gene1066	3.07e-05	45.1	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,4H9X4@91061|Bacilli,26CZP@186818|Planococcaceae	91061|Bacilli	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_815258_2	1047013.AQSP01000140_gene2544	2.7e-08	58.9	COG4591@1|root,COG4591@2|Bacteria,2NP18@2323|unclassified Bacteria	2|Bacteria	M	ABC-type transport system involved in lipoprotein release permease component	lolC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778	-	ko:K02004,ko:K09808	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.125	-	-	FtsX,MacB_PCD
k59_815319_1	323261.Noc_2863	1.61e-61	204.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1WWI1@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_815379_1	1198452.Jab_1c08720	1.07e-37	144.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2VJ3Z@28216|Betaproteobacteria,4795H@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MEDS,PAS_3,PAS_4,Response_reg
k59_815411_1	1034769.KB910518_gene1640	2.55e-40	149.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4H9NW@91061|Bacilli,26TK1@186822|Paenibacillaceae	91061|Bacilli	L	DNA polymerase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_815597_1	1094980.Mpsy_2244	9.55e-123	364.0	COG0286@1|root,arCOG02632@2157|Archaea,2XUMY@28890|Euryarchaeota,2NAA3@224756|Methanomicrobia	224756|Methanomicrobia	V	HsdM N-terminal domain	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
k59_815609_2	344747.PM8797T_00162	2.67e-09	59.7	COG1232@1|root,COG1232@2|Bacteria,2IWT1@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_815680_1	396588.Tgr7_2558	7.54e-69	223.0	COG0312@1|root,COG0312@2|Bacteria,1NSH6@1224|Proteobacteria,1RR3H@1236|Gammaproteobacteria,1WW71@135613|Chromatiales	135613|Chromatiales	S	modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
k59_815723_1	652103.Rpdx1_0117	3.17e-54	187.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,2U4RP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
k59_815723_2	522306.CAP2UW1_2572	2.1e-26	101.0	2AHT8@1|root,3185S@2|Bacteria,1RH98@1224|Proteobacteria,2VR76@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_815791_1	471853.Bcav_0004	6.2e-66	214.0	COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria	201174|Actinobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
k59_815904_1	768671.ThimaDRAFT_4448	1.72e-163	489.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1WWT9@135613|Chromatiales	1236|Gammaproteobacteria	O	Belongs to the ClpA ClpB family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
k59_816151_1	754477.Q7C_673	2.6e-33	128.0	COG3015@1|root,COG3187@1|root,COG3015@2|Bacteria,COG3187@2|Bacteria,1NZ8R@1224|Proteobacteria,1S0ZA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	MP	Copper homeostasis	cutF	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0010810,GO:0016020,GO:0019867,GO:0030155,GO:0030312,GO:0030313,GO:0031975,GO:0042802,GO:0044462,GO:0044464,GO:0050789,GO:0065007,GO:0071944	-	ko:K06079	ko01503,map01503	-	-	-	ko00000,ko00001	-	-	-	META,NlpE,NlpE_C
k59_816277_1	765914.ThisiDRAFT_0968	1.36e-106	328.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1WX1A@135613|Chromatiales	135613|Chromatiales	T	Putative nucleotidyltransferase substrate binding domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_816306_1	367299.JOEE01000001_gene2054	4.41e-83	269.0	COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,4FF98@85021|Intrasporangiaceae	201174|Actinobacteria	C	Catalyzes the transfer of electrons from NADH to quinone	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_816471_1	425104.Ssed_1749	5.4e-25	102.0	COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,1SAHT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA2	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_816571_1	1125863.JAFN01000001_gene17	2.75e-18	83.6	COG4566@1|root,COG4566@2|Bacteria,1PHNS@1224|Proteobacteria,431JN@68525|delta/epsilon subdivisions,2WWNY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_816571_2	1189619.pgond44_14063	1.46e-19	88.6	COG3292@1|root,COG4191@1|root,COG3292@2|Bacteria,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,1I0JH@117743|Flavobacteriia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,Reg_prop,Y_Y_Y
k59_816583_2	452637.Oter_2288	5.36e-25	97.4	COG0629@1|root,COG0629@2|Bacteria,46VZR@74201|Verrucomicrobia,3K80H@414999|Opitutae	414999|Opitutae	L	Single-stranded DNA-binding protein	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_816649_1	686340.Metal_2184	3.57e-59	194.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1XEEP@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_816683_1	196490.AUEZ01000095_gene5879	3.9e-23	101.0	COG3920@1|root,COG4191@1|root,COG3920@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TX7B@28211|Alphaproteobacteria,3K6ST@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	HWE histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HWE_HK,PAS_4
k59_816708_1	933262.AXAM01000008_gene1922	5.4e-142	421.0	COG0480@1|root,COG0480@2|Bacteria,1R0V4@1224|Proteobacteria,42M1F@68525|delta/epsilon subdivisions,2WIYM@28221|Deltaproteobacteria,2MHPT@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Elongation factor Tu domain 2	fusA-1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_816869_1	518766.Rmar_0342	1.9e-142	423.0	COG0209@1|root,COG0209@2|Bacteria,4NEHQ@976|Bacteroidetes,1FJVJ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrd	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
k59_816885_1	272560.BPSS2035	1.52e-69	220.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,2VHPB@28216|Betaproteobacteria,1KGV9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	beta-keto acid cleavage enzyme	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
k59_817066_1	2340.JV46_14100	3.6e-170	482.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RMGZ@1236|Gammaproteobacteria,1J7MS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_817076_1	1150469.RSPPHO_00399	2.98e-38	142.0	COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,2TTX1@28211|Alphaproteobacteria,2JQDM@204441|Rhodospirillales	204441|Rhodospirillales	O	Tellurite resistance protein TerB	djlA	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
k59_817189_1	264198.Reut_A2759	5.9e-37	132.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2VSCK@28216|Betaproteobacteria,1K00Y@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
k59_817199_1	319795.Dgeo_0886	9.9e-25	100.0	COG0479@1|root,COG0479@2|Bacteria,1WIEW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10,Fer4_8
k59_817199_2	1123376.AUIU01000016_gene222	2.32e-92	290.0	COG1053@1|root,COG1053@2|Bacteria,3J0ZM@40117|Nitrospirae	40117|Nitrospirae	C	Fumarate reductase flavoprotein C-term	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_817322_1	572477.Alvin_2601	9.68e-84	249.0	COG2210@1|root,COG2210@2|Bacteria,1RDUG@1224|Proteobacteria,1RRM7@1236|Gammaproteobacteria,1X23M@135613|Chromatiales	135613|Chromatiales	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
k59_817378_1	1122138.AQUZ01000017_gene6550	6.89e-26	108.0	COG2091@1|root,COG2091@2|Bacteria,2IQ65@201174|Actinobacteria,4DS9A@85009|Propionibacteriales	201174|Actinobacteria	H	4'-phosphopantetheinyl transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
k59_817582_1	1267005.KB911256_gene1846	2.27e-107	322.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2TQQ4@28211|Alphaproteobacteria,3N6DA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b
k59_817583_1	1434325.AZQN01000005_gene3628	3.67e-50	182.0	COG3321@1|root,COG3321@2|Bacteria,4PKD5@976|Bacteroidetes,47XYI@768503|Cytophagia	976|Bacteroidetes	Q	PKS_KR	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
k59_817618_1	35754.JNYJ01000089_gene6361	1.05e-58	199.0	COG0642@1|root,COG2205@2|Bacteria,2I2QY@201174|Actinobacteria,4DHBZ@85008|Micromonosporales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_817726_1	926569.ANT_30960	2.34e-94	283.0	COG1951@1|root,COG1951@2|Bacteria,2G6YI@200795|Chloroflexi	200795|Chloroflexi	C	Fumarate hydratase (Fumerase)	-	-	4.2.1.2	ko:K01676,ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
k59_817809_1	1173020.Cha6605_0364	1.96e-75	240.0	COG1653@1|root,COG1653@2|Bacteria,1GD71@1117|Cyanobacteria	1117|Cyanobacteria	G	PFAM Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
k59_817828_1	87626.PTD2_11474	1.66e-66	226.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,2PZGY@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_0027,iPC815.YPO0475	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_817836_1	1120956.JHZK01000003_gene274	8.86e-16	75.5	COG1873@1|root,COG1873@2|Bacteria,1QW30@1224|Proteobacteria,2UFA0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_FGFR
k59_817996_1	935839.JAGJ01000005_gene2667	1.46e-134	400.0	28MY8@1|root,2ZB54@2|Bacteria,2GMYY@201174|Actinobacteria,4F53A@85017|Promicromonosporaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_818140_1	765913.ThidrDRAFT_0916	9.39e-102	316.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1WWXP@135613|Chromatiales	135613|Chromatiales	J	small GTP-binding protein	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_818391_1	765911.Thivi_1025	1.15e-53	176.0	COG1977@1|root,COG3536@1|root,COG1977@2|Bacteria,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,1TKAA@1236|Gammaproteobacteria,1X136@135613|Chromatiales	135613|Chromatiales	H	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971,ThiS
k59_818391_2	111780.Sta7437_3828	2.14e-22	87.8	2E3CN@1|root,32YBX@2|Bacteria,1G8Z2@1117|Cyanobacteria,3VKKU@52604|Pleurocapsales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_818526_1	1178482.BJB45_20400	1.14e-05	46.2	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1XHJE@135619|Oceanospirillales	135619|Oceanospirillales	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
k59_818526_2	1122180.Lokhon_01664	9.54e-69	218.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2TR8F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0491 Zn-dependent hydrolases, including glyoxylases	soxH	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_818553_1	713586.KB900536_gene34	1.83e-116	363.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1WVV0@135613|Chromatiales	135613|Chromatiales	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_818557_1	1280674.AUJK01000034_gene1625	1.53e-27	110.0	COG1672@1|root,COG1672@2|Bacteria,4NGWE@976|Bacteroidetes	976|Bacteroidetes	S	PFAM Archaeal ATPase	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	ATPase_2,DUF234
k59_818583_1	159087.Daro_1130	9.62e-70	226.0	COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2VMKW@28216|Betaproteobacteria,2KYIB@206389|Rhodocyclales	206389|Rhodocyclales	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
k59_818662_1	1280953.HOC_19321	3.22e-16	75.1	COG3293@1|root,COG3293@2|Bacteria,1RDDI@1224|Proteobacteria,2UAE0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3293 Transposase and inactivated derivatives	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DUF4096
k59_818662_2	1267005.KB911258_gene482	1.01e-23	92.8	COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,2U9NV@28211|Alphaproteobacteria,3N7FE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	arsR	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20
k59_818696_1	670307.HYPDE_39883	4.51e-98	299.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,3N71B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	ammonium transporter	amtB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015291,GO:0015292,GO:0015669,GO:0015670,GO:0015696,GO:0015893,GO:0016020,GO:0016021,GO:0019755,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098655	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_818711_1	713587.THITH_06425	4.59e-22	97.1	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1WWVW@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM cytochrome c oxidase accessory protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
k59_818711_2	1454004.AW11_01642	6.06e-09	55.8	COG3198@1|root,COG3198@2|Bacteria,1N75J@1224|Proteobacteria,2VTYE@28216|Betaproteobacteria	28216|Betaproteobacteria	S	FixH	-	-	-	ko:K09926	-	-	-	-	ko00000	-	-	-	FixH
k59_818845_1	987059.RBXJA2T_12677	1.15e-19	82.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,2VSI3@28216|Betaproteobacteria,1KKSA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
k59_818845_2	340.xcc-b100_1634	3.71e-102	298.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,1X4BY@135614|Xanthomonadales	135614|Xanthomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_818879_1	768671.ThimaDRAFT_1995	0.000353	41.2	COG4783@1|root,COG4783@2|Bacteria,1N76P@1224|Proteobacteria,1T4CE@1236|Gammaproteobacteria,1X1B8@135613|Chromatiales	135613|Chromatiales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_818965_1	1217718.ALOU01000038_gene3331	1.4e-29	117.0	COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2VKAX@28216|Betaproteobacteria,1K3UW@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Chromate resistance	chrB	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
k59_819106_1	930169.B5T_03500	3.89e-22	102.0	COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,1XI39@135619|Oceanospirillales	135619|Oceanospirillales	M	(Lipo)protein	-	-	-	ko:K07121	-	-	-	-	ko00000	-	-	-	LppC
k59_819119_1	765910.MARPU_13905	1.39e-65	216.0	COG0318@1|root,COG0318@2|Bacteria,1MW0Y@1224|Proteobacteria,1RN35@1236|Gammaproteobacteria,1WX4Q@135613|Chromatiales	135613|Chromatiales	IQ	PFAM AMP-dependent synthetase	-	-	6.2.1.26	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_819148_1	504472.Slin_1659	6.33e-18	88.6	COG2202@1|root,COG4191@1|root,COG5002@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,4P2B2@976|Bacteroidetes,47QWM@768503|Cytophagia	976|Bacteroidetes	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_819204_1	1122933.JNIY01000003_gene1158	9.22e-169	483.0	COG0162@1|root,COG0162@2|Bacteria,2GJPR@201174|Actinobacteria,4F0UT@85016|Cellulomonadaceae	201174|Actinobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_819220_1	641526.ADIWIN_0940	6.45e-08	59.7	2E3AK@1|root,31XZF@2|Bacteria,4NRCU@976|Bacteroidetes,1I3MB@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_819262_1	469371.Tbis_1479	9.92e-33	123.0	COG0237@1|root,COG0237@2|Bacteria,2GN96@201174|Actinobacteria,4DYSR@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE,GrpB
k59_819280_1	1336233.JAEH01000046_gene3789	1.33e-65	214.0	COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,1RZYZ@1236|Gammaproteobacteria,2QATI@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_819356_1	933262.AXAM01000001_gene445	1.46e-63	217.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,2MHQJ@213118|Desulfobacterales	28221|Deltaproteobacteria	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_819368_1	1122182.KB903825_gene713	1.64e-71	223.0	COG0515@1|root,COG0515@2|Bacteria,2HUBD@201174|Actinobacteria	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_819430_1	717785.HYPMC_0764	9.22e-24	92.4	COG3750@1|root,COG3750@2|Bacteria,1N77J@1224|Proteobacteria,2UFX6@28211|Alphaproteobacteria,3N7B0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0335 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2312
k59_819476_1	876269.ARWA01000001_gene686	1.15e-19	90.1	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,3NAFU@45404|Beijerinckiaceae	28211|Alphaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	fixL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,MEDS,PAS,PAS_3,PAS_4,PAS_9
k59_819476_2	1027273.GZ77_15620	2.91e-71	222.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1XJ7K@135619|Oceanospirillales	135619|Oceanospirillales	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_819485_1	471853.Bcav_3048	1.88e-151	450.0	COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,2GJ5U@201174|Actinobacteria	201174|Actinobacteria	C	belongs to the CobB CobQ family	pta	GO:0005575,GO:0005576	2.3.1.8	ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,DRTGG,PTA_PTB
k59_819610_1	1535422.ND16A_1363	1.31e-84	269.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,2Q6Y5@267889|Colwelliaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_819668_1	446471.Xcel_2892	7.27e-70	232.0	COG1035@1|root,COG1035@2|Bacteria,2GM7P@201174|Actinobacteria,4F5F4@85017|Promicromonosporaceae	201174|Actinobacteria	C	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	FrhB_FdhB_C,FrhB_FdhB_N
k59_819675_1	1184609.KILIM_008_00090	9.3e-156	455.0	COG0038@1|root,COG0038@2|Bacteria,2GPPN@201174|Actinobacteria	201174|Actinobacteria	P	Chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	TrkA_C,Voltage_CLC
k59_819781_2	1415778.JQMM01000001_gene2175	2.43e-124	367.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1J56Y@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	-	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_1178995_1	29581.BW37_04898	1.45e-49	174.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,472YU@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_650780_1	1323361.JPOC01000028_gene3898	3e-15	84.0	COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,2GISC@201174|Actinobacteria,4FY3S@85025|Nocardiaceae	201174|Actinobacteria	L	SNF2 family N-terminal domain	helZ	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
k59_1648924_2	929712.KI912613_gene5020	5.93e-51	169.0	COG0522@1|root,COG0522@2|Bacteria,2GIRX@201174|Actinobacteria,4CRS4@84995|Rubrobacteria	84995|Rubrobacteria	J	Ribosomal protein S4/S9 N-terminal domain	-	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_6935_1	243161.TC_0787	3.37e-33	118.0	COG0105@1|root,COG0105@2|Bacteria,2JH29@204428|Chlamydiae	204428|Chlamydiae	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
k59_6935_2	1499967.BAYZ01000104_gene3626	7.06e-11	59.7	COG2331@1|root,COG2331@2|Bacteria,2NQXD@2323|unclassified Bacteria	2|Bacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
k59_1472865_1	631362.Thi970DRAFT_04432	4.73e-24	100.0	COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,1T2D1@1236|Gammaproteobacteria,1X28U@135613|Chromatiales	135613|Chromatiales	P	Sodium/hydrogen exchanger family	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger
k59_1472865_2	1348657.M622_03445	7.3e-34	128.0	COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,2VP0G@28216|Betaproteobacteria,2KVQK@206389|Rhodocyclales	206389|Rhodocyclales	P	COG0471 Di- and tricarboxylate transporters	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_1238002_2	1034943.BN1094_02596	1.38e-09	61.2	COG1426@1|root,COG1426@2|Bacteria,1PBSI@1224|Proteobacteria,1T8EH@1236|Gammaproteobacteria,1JDZI@118969|Legionellales	118969|Legionellales	S	Helix-turn-helix domain	-	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	HTH_25
k59_181093_1	1463909.KL585957_gene2958	2.15e-120	367.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria	201174|Actinobacteria	G	hydrolase, family 3	bgl2	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_298694_1	1380354.JIAN01000006_gene526	5.68e-58	201.0	COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria,4F0Y6@85016|Cellulomonadaceae	201174|Actinobacteria	L	DEAD DEAH box helicase domain protein	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
k59_592123_1	314278.NB231_15768	8.07e-22	99.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1WVZJ@135613|Chromatiales	135613|Chromatiales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_1414014_1	931627.MycrhDRAFT_2165	1.07e-246	688.0	COG1263@1|root,COG1264@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,2GKPM@201174|Actinobacteria,235ZF@1762|Mycobacteriaceae	201174|Actinobacteria	G	phosphotransferase system, EIIB	nagE	-	2.7.1.193	ko:K02802,ko:K02803,ko:K02804	ko00520,ko02060,map00520,map02060	M00267	R05199	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7	-	-	PTS_EIIA_1,PTS_EIIB,PTS_EIIC
k59_1179009_1	857087.Metme_0356	3.62e-15	74.3	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,1RM8D@1236|Gammaproteobacteria,1XET8@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_1179009_2	396588.Tgr7_0880	3.89e-46	155.0	COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,1RRXT@1236|Gammaproteobacteria,1X2ET@135613|Chromatiales	135613|Chromatiales	F	Deoxynucleoside kinase	-	-	-	-	-	-	-	-	-	-	-	-	dNK
k59_1299137_1	717785.HYPMC_0741	3.73e-20	88.2	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,2TTC7@28211|Alphaproteobacteria,3N6F2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_1299137_2	1244869.H261_18607	1.66e-39	142.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2TRHW@28211|Alphaproteobacteria,2JPV6@204441|Rhodospirillales	204441|Rhodospirillales	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
k59_533401_1	1123070.KB899249_gene264	2.52e-13	70.9	COG1236@1|root,COG1236@2|Bacteria,46SQ0@74201|Verrucomicrobia,2ITW2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Beta-Casp domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta-Casp,Lactamase_B,RMMBL
k59_240857_2	371731.Rsw2DRAFT_1853	6.85e-07	50.8	COG2516@1|root,COG2516@2|Bacteria,1MWZQ@1224|Proteobacteria,2U4HP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Radical SAM	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
k59_1002354_1	1713.JOFV01000002_gene574	8.92e-113	331.0	COG1682@1|root,COG1682@2|Bacteria,2GP5K@201174|Actinobacteria,4F2NK@85016|Cellulomonadaceae	201174|Actinobacteria	GM	ABC-2 type transporter	wzm	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_1179014_1	243233.MCA1214	1.89e-106	325.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1XDS9@135618|Methylococcales	135618|Methylococcales	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_181105_1	1142394.PSMK_08050	6.05e-90	282.0	COG3046@1|root,COG3046@2|Bacteria,2IY44@203682|Planctomycetes	203682|Planctomycetes	S	protein related to deoxyribodipyrimidine photolyase	-	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP,FAD_binding_7
k59_298703_1	593907.Celgi_0898	4.13e-78	249.0	COG1080@1|root,COG1080@2|Bacteria,2GIZZ@201174|Actinobacteria	201174|Actinobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_6968_1	861299.J421_4211	4.47e-54	181.0	COG0457@1|root,COG0457@2|Bacteria,1ZSYB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2
k59_359730_1	1300345.LF41_879	6e-37	134.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1X33P@135614|Xanthomonadales	135614|Xanthomonadales	C	Quinone oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_1827273_1	1304865.JAGF01000001_gene2260	5e-86	273.0	COG1263@1|root,COG1264@1|root,COG2190@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,COG2190@2|Bacteria,2GK6B@201174|Actinobacteria	201174|Actinobacteria	G	Pts system	bglF	-	-	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	M00271	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6	-	-	PTS_EIIA_1,PTS_EIIB,PTS_EIIC
k59_1299156_2	314278.NB231_13341	1.33e-34	132.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1X29W@135613|Chromatiales	135613|Chromatiales	NT	chemotaxis	-	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	MCPsignal,PilJ
k59_1062169_1	485913.Krac_1060	7.73e-40	137.0	COG0789@1|root,COG0789@2|Bacteria,2G9AM@200795|Chloroflexi	200795|Chloroflexi	K	Transcription regulator MerR DNA binding	-	-	-	ko:K13638	-	-	-	-	ko00000,ko03000	-	-	-	MerR,MerR-DNA-bind,MerR_1
k59_240880_1	1121918.ARWE01000001_gene21	6.83e-51	173.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,42QE5@68525|delta/epsilon subdivisions,2WM8R@28221|Deltaproteobacteria,43S58@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NQR2, RnfD, RnfE family	-	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
k59_1002361_2	1049564.TevJSym_bn00080	7.32e-88	269.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1J5P6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_359737_1	396588.Tgr7_2421	4.63e-205	577.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1WWJU@135613|Chromatiales	135613|Chromatiales	H	PFAM Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_181117_1	768671.ThimaDRAFT_4847	3.31e-172	487.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1WW00@135613|Chromatiales	135613|Chromatiales	H	Belongs to the ALAD family	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_826587_1	1341151.ASZU01000008_gene1474	6.24e-93	288.0	COG0281@1|root,COG0281@2|Bacteria,1UYHB@1239|Firmicutes,4HDRG@91061|Bacilli,27B6W@186824|Thermoactinomycetaceae	91061|Bacilli	C	Malic enzyme, N-terminal domain	mleA	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh_C,ACT_4,Malic_M,THF_DHG_CYH_C,malic
k59_1062178_1	1035308.AQYY01000002_gene762	7.72e-84	256.0	COG1064@1|root,COG1064@2|Bacteria,1TP5B@1239|Firmicutes,24GKF@186801|Clostridia	186801|Clostridia	C	TIGRFAM zinc-binding alcohol dehydrogenase family protein	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_6997_1	1163407.UU7_10551	4.49e-18	76.6	2E5S4@1|root,330GM@2|Bacteria,1NAY4@1224|Proteobacteria,1SEIX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_6997_2	406124.ACPC01000046_gene2387	6.69e-13	64.7	2DNMR@1|root,32Y5G@2|Bacteria,1VHJG@1239|Firmicutes,4HNHI@91061|Bacilli,1ZJE7@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_474630_3	1380387.JADM01000010_gene3920	2.07e-22	90.9	COG2940@1|root,COG2940@2|Bacteria,1NEQQ@1224|Proteobacteria,1SFED@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	lysine methyltransferase	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
k59_592151_1	382464.ABSI01000013_gene1559	0.000461	49.3	COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria,46WZH@74201|Verrucomicrobia,2IVZE@203494|Verrucomicrobiae	2|Bacteria	K	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C
k59_7001_1	1165841.SULAR_02558	6e-15	69.7	2DNSI@1|root,32YXC@2|Bacteria,1N7K2@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_7001_2	1177928.TH2_10124	3.87e-13	72.0	COG2207@1|root,COG2207@2|Bacteria,1R81X@1224|Proteobacteria,2TZJW@28211|Alphaproteobacteria,2JUGX@204441|Rhodospirillales	204441|Rhodospirillales	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding_2,HTH_18
k59_66276_1	1123368.AUIS01000020_gene1095	1.09e-50	173.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,2NCCE@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_66276_2	472759.Nhal_2631	1.21e-68	219.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1WWFA@135613|Chromatiales	135613|Chromatiales	E	PFAM Prephenate dehydratase	-	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
k59_1179039_1	880072.Desac_2720	5.35e-46	156.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,42QNS@68525|delta/epsilon subdivisions,2WMSN@28221|Deltaproteobacteria,2MQF7@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
k59_1531106_1	626939.HMPREF9443_00700	2.15e-33	124.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,4H35I@909932|Negativicutes	909932|Negativicutes	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_534185_1	1151126.AQYI01000002_gene336	1.15e-26	113.0	COG1305@1|root,COG1305@2|Bacteria,2HQBB@201174|Actinobacteria,4FMX9@85023|Microbacteriaceae	201174|Actinobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
k59_242240_1	96561.Dole_3052	3.75e-69	222.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ4Z@28221|Deltaproteobacteria,2MHXJ@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	PFAM type II secretion system protein E	pilT1	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_123140_1	443143.GM18_4036	1.31e-81	270.0	COG1360@1|root,COG2885@1|root,COG1360@2|Bacteria,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
k59_8373_1	1049564.TevJSym_ao00740	8.15e-76	236.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,1J4IH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Cell shape-determining protein	mreC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0043621,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944,GO:0071963	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
k59_651589_1	266264.Rmet_2705	9.39e-46	159.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2VHSA@28216|Betaproteobacteria,1K33P@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
k59_242245_1	1121352.JHZP01000002_gene1307	1.25e-49	160.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2VR7R@28216|Betaproteobacteria,2KQXS@206351|Neisseriales	206351|Neisseriales	E	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione	gloA	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
k59_242245_3	697282.Mettu_1221	3.84e-249	689.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria,1XEJG@135618|Methylococcales	135618|Methylococcales	F	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_1649702_1	187303.BN69_2285	4.66e-62	194.0	COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2U6ZN@28211|Alphaproteobacteria,36YEB@31993|Methylocystaceae	28211|Alphaproteobacteria	O	Redoxin	MA20_20905	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	Redoxin
k59_710193_1	1502770.JQMG01000001_gene908	8.68e-50	175.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2VJ75@28216|Betaproteobacteria,2KNIV@206350|Nitrosomonadales	206350|Nitrosomonadales	P	NnrS protein	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
k59_1300260_1	203122.Sde_0646	1.39e-45	155.0	COG3122@1|root,COG3122@2|Bacteria,1N15V@1224|Proteobacteria,1S5V0@1236|Gammaproteobacteria,467D6@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	yaiL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K09912	-	-	-	-	ko00000	-	-	iECW_1372.ECW_m0432,iWFL_1372.ECW_m0432	DUF2058
k59_1414866_1	247490.KSU1_C0120	1.41e-49	179.0	COG0474@1|root,COG0474@2|Bacteria,2IXV7@203682|Planctomycetes	203682|Planctomycetes	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,SBP_bac_1
k59_1239036_1	331869.BAL199_21004	3.97e-05	44.7	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TR1V@28211|Alphaproteobacteria,4BPQM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Respiratory-chain NADH dehydrogenase 51 Kd subunit	nuoEF	-	1.17.1.9,1.6.5.3	ko:K00122,ko:K00124,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_1239036_2	1469245.JFBG01000010_gene599	3.15e-158	473.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,1T1JA@1236|Gammaproteobacteria,1X2PM@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM formate dehydrogenase, alpha subunit	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_360794_1	1183438.GKIL_3602	9.31e-13	64.7	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_948048_1	1121405.dsmv_2225	1.87e-58	193.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,42RVN@68525|delta/epsilon subdivisions,2WNJW@28221|Deltaproteobacteria,2MNB1@213118|Desulfobacterales	28221|Deltaproteobacteria	M	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
k59_67345_1	411684.HPDFL43_01010	1.07e-48	161.0	COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,2U997@28211|Alphaproteobacteria,43JSH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0178 family	MA20_27470	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
k59_8394_1	765912.Thimo_2390	6.72e-81	253.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,1WWWJ@135613|Chromatiales	135613|Chromatiales	O	HflC and HflK could encode or regulate a protease	-	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
k59_1300265_1	1049564.TevJSym_ap00150	7.32e-88	277.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,1J55U@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	Q	Multicopper oxidase	pcoA	-	-	-	-	-	-	-	-	-	-	-	CopB,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_1300268_1	1348657.M622_16960	1.72e-56	197.0	COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,2VPRW@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Protein of unknown function (DUF1302)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1302
k59_948055_1	1249627.D779_1239	1.81e-73	231.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1WVUV@135613|Chromatiales	135613|Chromatiales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_948055_2	765912.Thimo_3105	7.47e-92	279.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1WXJ6@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_651604_1	1382306.JNIM01000001_gene2574	4.03e-46	165.0	COG1253@1|root,COG1253@2|Bacteria,2G6D1@200795|Chloroflexi	200795|Chloroflexi	S	CBS domain containing protein	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_1120345_1	83406.HDN1F_01240	1.37e-88	274.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1J4KM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	aminopeptidase	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_1120345_2	713586.KB900536_gene2595	4.69e-06	47.8	COG3079@1|root,COG3079@2|Bacteria,1N7W0@1224|Proteobacteria,1SCPW@1236|Gammaproteobacteria,1WYR7@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0149 family	-	-	-	ko:K09895	-	-	-	-	ko00000	-	-	-	UPF0149
k59_242274_1	1434929.X946_2967	3.07e-141	407.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2VH7F@28216|Betaproteobacteria,1K17M@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
k59_1414875_1	471853.Bcav_0903	4.55e-62	215.0	COG2366@1|root,COG2366@2|Bacteria,2GISQ@201174|Actinobacteria	201174|Actinobacteria	J	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_299445_1	1304865.JAGF01000001_gene3649	7.09e-29	118.0	2D1T0@1|root,32TBA@2|Bacteria,2I8E5@201174|Actinobacteria,4F1CG@85016|Cellulomonadaceae	201174|Actinobacteria	S	Copper transport outer membrane protein, MctB	mctB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0008150,GO:0009279,GO:0015267,GO:0015288,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0044425,GO:0044462,GO:0044464,GO:0046930,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098796	-	-	-	-	-	-	-	-	-	-	MctB
k59_1009449_2	446462.Amir_5190	1.91e-44	157.0	COG3429@1|root,COG3429@2|Bacteria,2GJ1H@201174|Actinobacteria,4E0XZ@85010|Pseudonocardiales	201174|Actinobacteria	G	PFAM Glucose-6-phosphate dehydrogenase subunit	opcA	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
k59_1075609_1	713586.KB900536_gene2691	1.7e-27	115.0	COG0651@1|root,COG0651@2|Bacteria,1N6BY@1224|Proteobacteria,1RR4C@1236|Gammaproteobacteria,1WWFY@135613|Chromatiales	135613|Chromatiales	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_190100_1	522306.CAP2UW1_1327	9.12e-60	206.0	COG1145@1|root,COG1290@1|root,COG1908@1|root,COG1145@2|Bacteria,COG1290@2|Bacteria,COG1908@2|Bacteria,1QSPU@1224|Proteobacteria,2VNFS@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_B,Fer4_7,FlpD
k59_541897_1	713587.THITH_12390	1.3e-11	70.9	COG3614@1|root,COG5001@1|root,COG3614@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVV9@135613|Chromatiales	135613|Chromatiales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GGDEF,HAMP,MASE1,PAS_9
k59_371742_1	991905.SL003B_3035	1.38e-200	562.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2TS7B@28211|Alphaproteobacteria,4BRM2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3039 Transposase and inactivated derivatives, IS5 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_1075616_1	257310.BB4854	5.04e-84	261.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2VJ7K@28216|Betaproteobacteria,3T2YB@506|Alcaligenaceae	28216|Betaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
k59_1773877_1	640511.BC1002_4705	6.42e-68	214.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2VNHU@28216|Betaproteobacteria,1K1PR@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_483127_1	1122135.KB893167_gene2170	7.95e-24	106.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2TRSN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	protein involved in outer membrane biogenesis	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
k59_1597886_1	697282.Mettu_0405	1.14e-215	629.0	COG3459@1|root,COG3459@2|Bacteria,1R1HB@1224|Proteobacteria,1T531@1236|Gammaproteobacteria,1XG0G@135618|Methylococcales	135618|Methylococcales	G	Glycosyltransferase 36 associated	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1250219_1	452637.Oter_0981	4.45e-83	261.0	COG2070@1|root,COG2070@2|Bacteria,46UTY@74201|Verrucomicrobia,3K79P@414999|Opitutae	414999|Opitutae	C	Nitronate monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
k59_1251104_1	1415778.JQMM01000001_gene2178	4.75e-89	266.0	COG0356@1|root,COG0356@2|Bacteria,1RBEV@1224|Proteobacteria,1T170@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	-	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1251104_2	1415778.JQMM01000001_gene2179	1.11e-37	128.0	COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,1SA80@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_1251104_3	1131553.JIBI01000039_gene1941	3.81e-13	67.4	COG0711@1|root,COG0711@2|Bacteria,1R6C0@1224|Proteobacteria,2VNRP@28216|Betaproteobacteria,372MR@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,DUF2934,OSCP
k59_132232_1	471853.Bcav_0742	4.52e-45	156.0	2CA7I@1|root,30E5G@2|Bacteria,2IJ78@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_719103_1	1120950.KB892798_gene2193	1.91e-78	254.0	COG0296@1|root,COG0296@2|Bacteria,2GJ5C@201174|Actinobacteria,4DPZS@85009|Propionibacteriales	201174|Actinobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0055114,GO:0071704,GO:0071944,GO:1901576	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_960056_1	998088.B565_2887	2.65e-37	147.0	COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1Y46M@135624|Aeromonadales	135624|Aeromonadales	MU	AAA domain	exeA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
k59_1598605_1	396588.Tgr7_0087	2.5e-99	317.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1WWSC@135613|Chromatiales	135613|Chromatiales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_775131_2	631362.Thi970DRAFT_04271	5.19e-94	291.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1WWMF@135613|Chromatiales	135613|Chromatiales	O	PFAM Magnesium chelatase, ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_1364322_1	330084.JNYZ01000026_gene2573	1.63e-41	152.0	COG1061@1|root,COG4951@1|root,COG1061@2|Bacteria,COG4951@2|Bacteria,2GIR9@201174|Actinobacteria	201174|Actinobacteria	L	helicase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Helicase_C,Lsr2,ResIII
k59_1364322_2	1089545.KB913037_gene3398	7.49e-32	122.0	COG1061@1|root,COG1061@2|Bacteria,2H66X@201174|Actinobacteria	201174|Actinobacteria	KL	Type III restriction enzyme res subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1486105_1	1121403.AUCV01000017_gene4526	6.4e-35	127.0	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,42M4E@68525|delta/epsilon subdivisions,2WKFT@28221|Deltaproteobacteria,2MIBF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
k59_1486105_2	1265505.ATUG01000003_gene541	8.42e-21	91.3	COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria,2MHQP@213118|Desulfobacterales	28221|Deltaproteobacteria	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
k59_1188990_1	351607.Acel_0139	2.22e-26	109.0	COG3408@1|root,COG3408@2|Bacteria,2GIUI@201174|Actinobacteria,4EUUE@85013|Frankiales	201174|Actinobacteria	G	N-terminal domain of (some) glycogen debranching enzymes	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
k59_1188990_2	396014.BF93_04890	5.17e-82	249.0	28JJ5@1|root,2Z9C9@2|Bacteria,2HB8W@201174|Actinobacteria,4FDF1@85020|Dermabacteraceae	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
k59_372849_1	1038859.AXAU01000002_gene309	6.44e-41	153.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,3JTZ5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	MA20_07375	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
k59_901093_1	246199.CUS_7758	3.98e-07	56.2	COG3735@1|root,COG3735@2|Bacteria,1V7NU@1239|Firmicutes,24IJ8@186801|Clostridia,3WJ4J@541000|Ruminococcaceae	186801|Clostridia	S	TraB family	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
k59_901093_2	754477.Q7C_1384	7.22e-12	63.9	COG0235@1|root,COG0235@2|Bacteria,1QAVF@1224|Proteobacteria,1RW3I@1236|Gammaproteobacteria,4628Z@72273|Thiotrichales	72273|Thiotrichales	G	PFAM Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
k59_1423958_1	794846.AJQU01000118_gene5102	8.46e-81	256.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,4B9CT@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1423958_2	745014.OMB55_00014350	1.3e-11	64.7	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1J54P@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_960074_1	566466.NOR53_2935	1.04e-37	145.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1SYWH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_960074_2	419947.MRA_3171	1.92e-09	57.8	COG1180@1|root,COG1180@2|Bacteria,2HQU0@201174|Actinobacteria,237XE@1762|Mycobacteriaceae	201174|Actinobacteria	H	Radical SAM superfamily	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
k59_1598617_1	572477.Alvin_2030	3.28e-90	271.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,1RNSW@1236|Gammaproteobacteria,1WWX4@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
k59_1364333_1	991905.SL003B_3826	4.58e-40	152.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2TSVH@28211|Alphaproteobacteria,4BPQH@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Putative amidoligase enzyme (DUF2126)	MA20_16195	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
k59_1774622_1	1249627.D779_3058	1.77e-46	152.0	COG0607@1|root,COG0607@2|Bacteria,1QMXA@1224|Proteobacteria,1S6DI@1236|Gammaproteobacteria,1X2DB@135613|Chromatiales	135613|Chromatiales	P	PFAM Rhodanese-like	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1774622_2	768671.ThimaDRAFT_2003	6.11e-13	62.8	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,1S8TC@1236|Gammaproteobacteria,1X2H5@135613|Chromatiales	135613|Chromatiales	O	Sulfurtransferase TusA	-	-	-	-	-	-	-	-	-	-	-	-	TusA
k59_190880_1	1121939.L861_14390	3.17e-10	60.5	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1XRDR@135619|Oceanospirillales	135619|Oceanospirillales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_190880_2	713586.KB900536_gene1527	3.95e-13	69.3	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RMKV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Amino Acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_1251127_1	472759.Nhal_0795	9.28e-62	214.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1WWAA@135613|Chromatiales	135613|Chromatiales	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,SurA_N_3
k59_1364341_1	318167.Sfri_0290	5.25e-51	179.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,2QAFC@267890|Shewanellaceae	1236|Gammaproteobacteria	P	TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_79264_1	1121935.AQXX01000131_gene2773	2.8e-20	92.0	COG1073@1|root,COG1073@2|Bacteria,1MZUA@1224|Proteobacteria,1S9ZY@1236|Gammaproteobacteria,1XM1G@135619|Oceanospirillales	135619|Oceanospirillales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
k59_372864_1	864051.BurJ1DRAFT_0976	5.5e-16	82.4	COG5309@1|root,COG5309@2|Bacteria	2|Bacteria	G	chondroitin AC lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_17
k59_1127733_1	458817.Shal_3669	1.7e-50	172.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,2QATB@267890|Shewanellaceae	1236|Gammaproteobacteria	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008784,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0019842,GO:0030170,GO:0030203,GO:0034645,GO:0036094,GO:0036361,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0048037,GO:0050662,GO:0070279,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	iPC815.YPO0321,iSBO_1134.SBO_4064,iSbBS512_1146.SbBS512_E4542,iYL1228.KPN_04440	Ala_racemase_C,Ala_racemase_N
k59_190884_1	1403819.BATR01000090_gene2627	4.87e-38	140.0	COG0006@1|root,COG0006@2|Bacteria,46U30@74201|Verrucomicrobia,2ITPD@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Aminopeptidase P, N-terminal domain	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_425101_1	596151.DesfrDRAFT_3229	4.17e-18	88.6	COG1215@1|root,COG1215@2|Bacteria,1MXG7@1224|Proteobacteria,42Q7W@68525|delta/epsilon subdivisions,2WKZ8@28221|Deltaproteobacteria,2MGZY@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.212	ko:K00752,ko:K11936	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.1.1.10,4.D.1.1.2,4.D.1.1.3,4.D.1.1.4,4.D.1.1.5	GT2	-	Glyco_tranf_2_3,Glycos_transf_2
k59_600922_1	4577.GRMZM2G363552_P01	1.28e-08	62.8	COG1404@1|root,2QPQR@2759|Eukaryota,37YNJ@33090|Viridiplantae,3GN46@35493|Streptophyta,3KU8R@4447|Liliopsida,3I3BW@38820|Poales	35493|Streptophyta	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,Peptidase_S8
k59_1658829_1	1353537.TP2_00595	4.94e-118	360.0	COG1994@1|root,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,2U0H8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Peptidase, M50 family	-	-	-	ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	Biotin_lipoyl_2,PqqD
k59_1364346_1	1385519.N801_04440	4.05e-13	72.0	COG2345@1|root,COG2345@2|Bacteria,2IAWJ@201174|Actinobacteria,4FHY6@85021|Intrasporangiaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_IclR,MarR_2
k59_1364346_2	1321775.HMPREF1980_00522	3.98e-51	174.0	COG0676@1|root,COG0676@2|Bacteria,2IIUH@201174|Actinobacteria,4D4GC@85005|Actinomycetales	201174|Actinobacteria	G	Belongs to the glucose-6-phosphate 1-epimerase family	-	-	5.1.3.15	ko:K01792	ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130	-	R02739	RC00563	ko00000,ko00001,ko01000	-	-	-	Aldose_epim
k59_1840491_1	1121129.KB903367_gene2689	3.49e-10	64.7	COG0526@1|root,COG0526@2|Bacteria,4NEX3@976|Bacteroidetes,2FN8N@200643|Bacteroidia	976|Bacteroidetes	CO	AhpC Tsa family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DUF4369,Redoxin,Thioredoxin_8
k59_1840491_2	402626.Rpic_3268	8.2e-07	50.8	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,1K0BI@119060|Burkholderiaceae	28216|Betaproteobacteria	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_2,Thioredoxin_7
k59_483868_2	158190.SpiGrapes_2261	7.36e-75	243.0	COG0438@1|root,COG0438@2|Bacteria,2JAVP@203691|Spirochaetes	203691|Spirochaetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_132270_2	472759.Nhal_2364	7.46e-129	384.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1WWEC@135613|Chromatiales	135613|Chromatiales	S	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
k59_1658839_1	1184607.AUCHE_08_00670	5.76e-76	233.0	COG0588@1|root,COG0588@2|Bacteria,2GK8F@201174|Actinobacteria,4F60Q@85018|Dermatophilaceae	201174|Actinobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031323,GO:0031329,GO:0032787,GO:0032991,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
k59_372887_1	224911.27356273	3.39e-11	62.4	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VEU2@28211|Alphaproteobacteria,3JV0I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Evidence Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran
k59_372887_2	266779.Meso_2282	9.69e-36	136.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2TTJZ@28211|Alphaproteobacteria,43JFR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1364353_1	187272.Mlg_2407	2.56e-82	276.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales	135613|Chromatiales	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_372888_1	1121439.dsat_1460	1.33e-68	228.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1QZPK@1224|Proteobacteria,42NQE@68525|delta/epsilon subdivisions,2WJPH@28221|Deltaproteobacteria,2M8MZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_4,PAS_9,Response_reg
k59_1076789_1	671143.DAMO_0963	6.13e-68	231.0	COG3696@1|root,COG3696@2|Bacteria,2NNKZ@2323|unclassified Bacteria	2|Bacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	cusA	-	-	ko:K07787,ko:K15726	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.2,2.A.6.1.4	-	iAF987.Gmet_1547	ACR_tran
k59_1189025_1	1121405.dsmv_2738	4.29e-113	345.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,2MIS9@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_1840512_1	13689.BV96_04745	4.39e-98	300.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2K2UN@204457|Sphingomonadales	204457|Sphingomonadales	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_307684_1	313589.JNB_19128	2.95e-78	254.0	COG0438@1|root,COG1413@1|root,COG0438@2|Bacteria,COG1413@2|Bacteria,2HMNV@201174|Actinobacteria,4FFZP@85021|Intrasporangiaceae	201174|Actinobacteria	CM	Glycosyltransferase Family 4	-	-	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1,HEAT_2
k59_542698_1	768671.ThimaDRAFT_2161	1.17e-99	314.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales	135613|Chromatiales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2
k59_132281_2	1049564.TevJSym_be00350	7.67e-102	301.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RMWT@1236|Gammaproteobacteria,1J59F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoP	-	-	ko:K07660	ko01503,ko02020,map01503,map02020	M00444,M00709,M00721,M00723,M00724,M00744	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_257124_1	686340.Metal_2503	3e-31	120.0	COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,1RNPD@1236|Gammaproteobacteria,1XEEY@135618|Methylococcales	135618|Methylococcales	D	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity	zapD	-	-	ko:K18778	-	-	-	-	ko00000,ko03036	-	-	-	ZapD
k59_1189028_1	631362.Thi970DRAFT_04920	2.03e-73	238.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,1RYHK@1236|Gammaproteobacteria,1WXMQ@135613|Chromatiales	135613|Chromatiales	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_1076800_1	446466.Cfla_2675	5.65e-100	295.0	COG0081@1|root,COG0081@2|Bacteria,2GM51@201174|Actinobacteria,4F0Y8@85016|Cellulomonadaceae	201174|Actinobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_901164_1	1297742.A176_07285	5.51e-29	113.0	COG1075@1|root,COG1075@2|Bacteria,1MXXB@1224|Proteobacteria,438M0@68525|delta/epsilon subdivisions,2X3VC@28221|Deltaproteobacteria,2YX83@29|Myxococcales	28221|Deltaproteobacteria	S	Lipase (class 2)	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_2
k59_1540334_1	1232683.ADIMK_2483	1.18e-69	224.0	COG0270@1|root,COG4190@1|root,COG0270@2|Bacteria,COG4190@2|Bacteria,1MV9H@1224|Proteobacteria,1RPM4@1236|Gammaproteobacteria,467KH@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	COG0270 Site-specific DNA methylase	dcm	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
k59_1010134_1	40571.JOEA01000021_gene6826	5.11e-124	381.0	COG2304@1|root,COG2304@2|Bacteria,2GJRP@201174|Actinobacteria	201174|Actinobacteria	S	tyrosinase	-	-	1.14.18.1	ko:K00505	ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916	M00042	R00731,R02078,R02363,R02383,R04693,R04884	RC00046,RC00150,RC00180	ko00000,ko00001,ko00002,ko01000	-	-	-	Tyrosinase
k59_190918_1	717785.HYPMC_0636	1.83e-95	294.0	COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,2TS4Z@28211|Alphaproteobacteria,3N994@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	MatE	matE	-	-	-	-	-	-	-	-	-	-	-	MatE
k59_132285_1	590998.Celf_3510	1.38e-201	574.0	COG1066@1|root,COG1066@2|Bacteria,2GMQ0@201174|Actinobacteria,4F1T5@85016|Cellulomonadaceae	201174|Actinobacteria	L	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
k59_132285_2	1454010.JEOE01000065_gene2082	6.11e-05	48.5	2EHBK@1|root,33B3F@2|Bacteria,2ICD4@201174|Actinobacteria,4F1KC@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1251177_1	331678.Cphamn1_2495	1.13e-22	101.0	COG1483@1|root,COG1483@2|Bacteria	2|Bacteria	C	ATPase (AAA superfamily	-	-	3.1.26.3	ko:K03685,ko:K06922	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	DUF499
k59_775179_1	204669.Acid345_4083	1.9e-112	350.0	COG1195@1|root,COG3593@1|root,COG1195@2|Bacteria,COG3593@2|Bacteria,3Y7ZQ@57723|Acidobacteria	57723|Acidobacteria	L	Protein of unknown function (DUF2813)	-	-	-	ko:K07459	-	-	-	-	ko00000	-	-	-	DUF2813
k59_1312325_1	395019.Bmul_2095	1.46e-29	112.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHGM@28216|Betaproteobacteria,1K4PE@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	fbpC	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
k59_1312325_2	1049564.TevJSym_af00050	2.02e-144	427.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,1RP55@1236|Gammaproteobacteria,1J588@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	fbpB	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_257144_1	343509.SG1616	6.55e-11	65.9	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,1RMB0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_1997,iSDY_1059.SDY_2514	Mur_ligase_C,Mur_ligase_M
k59_901183_1	467661.RKLH11_1310	1.92e-61	199.0	COG1082@1|root,COG1082@2|Bacteria,1R3UQ@1224|Proteobacteria,2U2AH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
k59_1312327_1	631362.Thi970DRAFT_03957	1.25e-78	263.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWJ6@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_660613_1	498211.CJA_0537	1.35e-28	119.0	COG1075@1|root,COG2303@1|root,COG1075@2|Bacteria,COG2303@2|Bacteria,1QQ8F@1224|Proteobacteria,1SYXY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	GMC oxidoreductase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N,PhoD
k59_1716283_1	935863.AWZR01000003_gene2853	2.27e-88	288.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1X3MQ@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_425142_1	335543.Sfum_1181	1.74e-215	608.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_966229_1	765912.Thimo_3043	8.47e-91	281.0	COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,1RPDV@1236|Gammaproteobacteria,1WXSP@135613|Chromatiales	135613|Chromatiales	G	alpha beta alpha domain I	-	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_136668_1	494419.ALPM01000122_gene1280	1e-79	255.0	COG0177@1|root,COG0177@2|Bacteria,2GNE5@201174|Actinobacteria	201174|Actinobacteria	L	PFAM HhH-GPD family protein	-	-	-	-	-	-	-	-	-	-	-	-	HhH-GPD
k59_664915_1	189753.AXAS01000023_gene789	1.18e-22	103.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2TT0E@28211|Alphaproteobacteria,3JTSC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_85439_1	1385519.N801_12410	4.08e-93	286.0	COG3266@1|root,COG3266@2|Bacteria,2I44K@201174|Actinobacteria,4FHHE@85021|Intrasporangiaceae	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_85439_2	367299.JOEE01000005_gene3442	2.96e-12	63.5	COG3012@1|root,COG3012@2|Bacteria,2IQEM@201174|Actinobacteria,4FHH7@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the UPF0225 family	ychJ	-	-	ko:K09858	-	-	-	-	ko00000	-	-	-	SEC-C
k59_840672_2	760568.Desku_2648	7.91e-08	55.8	COG0589@1|root,COG0589@2|Bacteria,1V1UN@1239|Firmicutes,24HEQ@186801|Clostridia	186801|Clostridia	T	PFAM UspA	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_840672_3	306537.jk1918	2.75e-18	77.4	COG1773@1|root,COG1773@2|Bacteria,2HN5Z@201174|Actinobacteria,22PI0@1653|Corynebacteriaceae	201174|Actinobacteria	C	Rubredoxin	rubA	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
k59_1720772_1	1267005.KB911257_gene987	2.76e-85	259.0	COG3176@1|root,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,2TUVA@28211|Alphaproteobacteria,3N6YK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Acetyltransferase (GNAT) domain	olsB	-	2.3.2.30	ko:K22310	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_5
k59_429515_1	439235.Dalk_3671	2.1e-100	302.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42M19@68525|delta/epsilon subdivisions,2WIYH@28221|Deltaproteobacteria,2MI08@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Branched-chain amino acid transport system / permease component	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1368852_1	996637.SGM_4443	3.83e-49	167.0	COG2816@1|root,COG2816@2|Bacteria,2GJZY@201174|Actinobacteria	201174|Actinobacteria	L	NADH pyrophosphatase	nudC	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
k59_1846642_1	305900.GV64_02520	1.03e-49	178.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1XIQW@135619|Oceanospirillales	135619|Oceanospirillales	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
k59_1082724_1	765912.Thimo_3680	2.13e-23	99.8	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1WWFQ@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
k59_1779332_1	395493.BegalDRAFT_0979	2.02e-82	249.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,46063@72273|Thiotrichales	72273|Thiotrichales	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_1779332_2	768671.ThimaDRAFT_1435	1.1e-118	343.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria,1WWPE@135613|Chromatiales	135613|Chromatiales	G	HAD-superfamily hydrolase, subfamily IA, variant 3	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_195278_1	1118054.CAGW01000048_gene1662	3.83e-07	54.3	COG4638@1|root,COG4638@2|Bacteria,1UZWG@1239|Firmicutes,4HBGQ@91061|Bacilli,26RJZ@186822|Paenibacillaceae	91061|Bacilli	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_195278_2	1323663.AROI01000033_gene4042	1.61e-06	47.8	COG1942@1|root,COG1942@2|Bacteria	2|Bacteria	S	isomerase activity	xylH	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
k59_1318486_1	379731.PST_1105	4.98e-40	149.0	28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria,1YZPU@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1329
k59_1491474_1	1423144.Gal_01894	1.09e-59	199.0	COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2TSX2@28211|Alphaproteobacteria,34ETS@302485|Phaeobacter	28211|Alphaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
k59_723345_1	1266998.ATUJ01000002_gene2055	8.74e-91	278.0	COG1304@1|root,COG1304@2|Bacteria,1N6KI@1224|Proteobacteria,2U0KU@28211|Alphaproteobacteria,2PX11@265|Paracoccus	28211|Alphaproteobacteria	C	FMN-dependent dehydrogenase	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
k59_488292_1	1463895.JODA01000031_gene2666	2.5e-68	216.0	COG0560@1|root,COG0560@2|Bacteria,2GKRQ@201174|Actinobacteria	201174|Actinobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
k59_605479_1	1499967.BAYZ01000008_gene5416	5.48e-28	107.0	COG0765@1|root,COG0765@2|Bacteria,2NPKZ@2323|unclassified Bacteria	2|Bacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
k59_605479_2	1121405.dsmv_0095	9.59e-31	114.0	COG0765@1|root,COG0765@2|Bacteria,1QE11@1224|Proteobacteria,42PWZ@68525|delta/epsilon subdivisions,2WM71@28221|Deltaproteobacteria,2MITV@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
k59_263824_1	472759.Nhal_0036	6.05e-58	201.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1WX02@135613|Chromatiales	135613|Chromatiales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_263824_2	339671.Asuc_0723	2.88e-29	117.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1Y7IK@135625|Pasteurellales	135625|Pasteurellales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_195292_1	1163617.SCD_n01561	1.31e-67	230.0	28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria,2VZ4M@28216|Betaproteobacteria	28216|Betaproteobacteria	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
k59_605480_1	1249627.D779_1785	1.64e-116	368.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1WX8F@135613|Chromatiales	135613|Chromatiales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_907338_1	268407.PWYN_19470	2.63e-18	84.7	COG3007@1|root,COG3007@2|Bacteria,1TWIF@1239|Firmicutes,4HCSV@91061|Bacilli,26SS7@186822|Paenibacillaceae	91061|Bacilli	I	Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA)	fabV	-	1.3.1.44,1.3.1.9	ko:K00209	ko00061,ko00650,ko01100,ko01120,ko01200,ko01212,map00061,map00650,map01100,map01120,map01200,map01212	M00083	R01171,R04429,R04724,R04955,R04958,R04961,R04966,R04969	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Eno-Rase_FAD_bd,Eno-Rase_NADH_b,Enoyl_reductase
k59_907338_2	370438.PTH_2594	4.37e-29	114.0	COG0014@1|root,COG0014@2|Bacteria,1TQ9V@1239|Firmicutes,248NX@186801|Clostridia,260NX@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_263827_1	446465.Bfae_12240	7.05e-75	238.0	COG3919@1|root,COG3919@2|Bacteria,2GM4D@201174|Actinobacteria,4FBI6@85020|Dermabacteraceae	201174|Actinobacteria	S	ATP-grasp	-	-	6.3.1.12	ko:K17810	-	-	-	-	ko00000,ko01000	-	-	-	CPSase_L_D2
k59_1082750_1	377629.TERTU_1671	8.52e-09	55.1	COG0848@1|root,COG0848@2|Bacteria,1RHI8@1224|Proteobacteria,1S6FK@1236|Gammaproteobacteria,2PPX7@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
k59_1082750_2	396588.Tgr7_0539	9.7e-64	201.0	COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1RMSA@1236|Gammaproteobacteria,1X07Q@135613|Chromatiales	135613|Chromatiales	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_312327_1	1121949.AQXT01000002_gene2090	6.48e-13	69.7	COG4307@1|root,COG4307@2|Bacteria,1MW31@1224|Proteobacteria,2TRR9@28211|Alphaproteobacteria,43ZC4@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Putative zinc-binding metallo-peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx,zinc-ribbon_6
k59_312327_2	876269.ARWA01000001_gene8	5.14e-17	76.3	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2TX4N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_195293_1	136993.KB900627_gene67	2.25e-44	172.0	COG2706@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG3291@1|root,COG2706@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,DUF5122,HemolysinCabind,Lactonase,Laminin_G_3,Peptidase_M10_C,W_rich_C
k59_1318520_1	1713.JOFV01000004_gene3297	7.76e-27	104.0	COG1438@1|root,COG1438@2|Bacteria,2GKA5@201174|Actinobacteria,4F27G@85016|Cellulomonadaceae	201174|Actinobacteria	K	Regulates arginine biosynthesis genes	argR	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
k59_1318520_2	471853.Bcav_2369	5.67e-25	100.0	COG0078@1|root,COG0078@2|Bacteria,2GJ6H@201174|Actinobacteria	201174|Actinobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_1193439_1	1713.JOFV01000002_gene505	1.15e-96	297.0	COG0460@1|root,COG0460@2|Bacteria,2GIX9@201174|Actinobacteria,4F0FA@85016|Cellulomonadaceae	201174|Actinobacteria	E	amino acid-binding ACT domain protein	hom	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.1.1.3,2.7.2.4	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1294	ACT,Homoserine_dh,NAD_binding_3
k59_723368_1	96561.Dole_2313	1.32e-88	277.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2MI74@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	Sigma-54 interaction domain	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	HTH_8,PAS_4,PAS_9,Sigma54_activat
k59_1428483_1	1128421.JAGA01000004_gene2609	1.71e-126	372.0	COG2224@1|root,COG2224@2|Bacteria	2|Bacteria	C	isocitrate lyase activity	aceA	GO:0001101,GO:0001666,GO:0003674,GO:0003824,GO:0004451,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0006102,GO:0006950,GO:0008150,GO:0008152,GO:0009268,GO:0009405,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0010033,GO:0010034,GO:0010447,GO:0016020,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0019899,GO:0032787,GO:0033554,GO:0033993,GO:0035375,GO:0036293,GO:0036294,GO:0042221,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046421,GO:0046487,GO:0046677,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0070482,GO:0070542,GO:0070887,GO:0071453,GO:0071456,GO:0071704,GO:0071944,GO:0072350,GO:0075136,GO:0075141,GO:1901700	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	e_coli_core.b4015,iAF1260.b4015,iB21_1397.B21_03847,iBWG_1329.BWG_3671,iE2348C_1286.E2348C_4318,iEC042_1314.EC042_4377,iEC55989_1330.EC55989_4500,iECABU_c1320.ECABU_c45310,iECBD_1354.ECBD_4022,iECB_1328.ECB_03887,iECDH10B_1368.ECDH10B_4204,iECDH1ME8569_1439.ECDH1ME8569_3871,iECD_1391.ECD_03887,iECED1_1282.ECED1_4722,iECIAI1_1343.ECIAI1_4235,iECIAI39_1322.ECIAI39_4401,iECNA114_1301.ECNA114_4164,iECO103_1326.ECO103_4759,iECO111_1330.ECO111_4827,iECO26_1355.ECO26_5119,iECP_1309.ECP_4225,iECSE_1348.ECSE_4300,iECSF_1327.ECSF_3865,iECUMN_1333.ECUMN_4541,iECW_1372.ECW_m4374,iEKO11_1354.EKO11_4310,iETEC_1333.ETEC_4270,iEcDH1_1363.EcDH1_3982,iEcE24377_1341.EcE24377A_4557,iEcHS_1320.EcHS_A4249,iEcSMS35_1347.EcSMS35_4469,iEcolC_1368.EcolC_4015,iJN746.PP_4116,iJO1366.b4015,iJR904.b4015,iLF82_1304.LF82_0012,iNRG857_1313.NRG857_20015,iSDY_1059.SDY_4328,iUMNK88_1353.UMNK88_4859,iWFL_1372.ECW_m4374,iY75_1357.Y75_RS20880	ICL
k59_1082771_1	880072.Desac_0544	2.88e-77	256.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MSJC@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	por	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_546861_5	1121896.JMLU01000052_gene1260	5.42e-43	160.0	2BFD6@1|root,3296M@2|Bacteria,4NQWY@976|Bacteroidetes,1I31C@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_966290_1	1115803.HMPREF1129_2731	3.85e-19	85.9	29XST@1|root,30JIN@2|Bacteria,2HV2E@201174|Actinobacteria,4D5GK@85005|Actinomycetales	201174|Actinobacteria	S	Domain of unknown function (DUF4352)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4352
k59_966290_2	396014.BF93_06195	1.49e-29	116.0	COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria,4FBKI@85020|Dermabacteraceae	201174|Actinobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1368889_1	935863.AWZR01000013_gene1535	2.42e-13	70.5	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1X3HH@135614|Xanthomonadales	135614|Xanthomonadales	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_1368889_2	743721.Psesu_2357	4.35e-31	122.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1X4P8@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_1720813_1	1249627.D779_2738	8.05e-116	345.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,1WW94@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_606287_2	1121127.JAFA01000027_gene118	3.57e-149	428.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2VIE7@28216|Betaproteobacteria,1K1B6@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
k59_1369620_1	313595.P700755_002871	6.81e-62	210.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,1HY3A@117743|Flavobacteriia,4C2VQ@83612|Psychroflexus	976|Bacteroidetes	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
k59_1847813_1	1123257.AUFV01000013_gene2779	7.47e-78	243.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria,1X7SD@135614|Xanthomonadales	135614|Xanthomonadales	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_265015_1	1382305.AZUC01000047_gene718	2.34e-34	133.0	COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,4HAG2@91061|Bacilli,26E1G@186818|Planococcaceae	91061|Bacilli	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_908457_1	1265313.HRUBRA_00889	4.83e-170	478.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,1RXYF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Integrase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_1780102_1	909663.KI867150_gene80	8.73e-73	238.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,43BFJ@68525|delta/epsilon subdivisions,2X6TY@28221|Deltaproteobacteria,2MQ4R@213462|Syntrophobacterales	1224|Proteobacteria	J	GAD domain	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_547597_1	1255043.TVNIR_2576	3.74e-194	545.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1WWIK@135613|Chromatiales	135613|Chromatiales	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_967415_1	713586.KB900536_gene148	1.72e-19	81.3	COG1393@1|root,COG1393@2|Bacteria,1MZ6S@1224|Proteobacteria,1S8TR@1236|Gammaproteobacteria,1WYR9@135613|Chromatiales	135613|Chromatiales	P	Belongs to the ArsC family	-	-	-	-	-	-	-	-	-	-	-	-	ArsC
k59_967415_2	1002339.HMPREF9373_0438	1.04e-75	233.0	COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,1RPCS@1236|Gammaproteobacteria,3NINN@468|Moraxellaceae	1236|Gammaproteobacteria	E	Belongs to the transferase hexapeptide repeat family	dapD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008666,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	iSbBS512_1146.SbBS512_E0158	Hexapep,Hexapep_2,THDPS_N_2
k59_1319677_1	1232437.KL662015_gene1286	1.21e-66	213.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2WK0K@28221|Deltaproteobacteria,2MIH5@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_779629_1	1121116.KB894766_gene228	2.42e-14	71.2	COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,2VMXI@28216|Betaproteobacteria,4AAZ1@80864|Comamonadaceae	28216|Betaproteobacteria	K	response regulator, receiver	narL	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k59_779629_2	1395571.TMS3_0102110	5.01e-32	115.0	COG0599@1|root,COG0599@2|Bacteria,1N2ZQ@1224|Proteobacteria,1SBZC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_908472_1	368407.Memar_1426	2.75e-56	191.0	COG1055@1|root,arCOG00238@2157|Archaea,2XVDU@28890|Euryarchaeota,2N961@224756|Methanomicrobia	224756|Methanomicrobia	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_1194233_1	1095767.CAHD01000122_gene2467	8.3e-77	239.0	COG0345@1|root,COG0345@2|Bacteria,2GJ7D@201174|Actinobacteria,4F0WU@85016|Cellulomonadaceae	201174|Actinobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
k59_967428_1	546414.Deide_14890	1.77e-27	113.0	COG1960@1|root,COG1960@2|Bacteria,1WJ4I@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1369642_2	2340.JV46_18710	2.23e-47	154.0	COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,1S5WU@1236|Gammaproteobacteria,1J6QE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	ybaB	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:1901363	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
k59_489109_2	5888.CAK88748	8.5e-06	50.4	COG0664@1|root,KOG1113@2759|Eukaryota	2759|Eukaryota	T	cAMP-dependent protein kinase regulator activity	PRKAR1A	GO:0000003,GO:0000166,GO:0000187,GO:0000226,GO:0000280,GO:0001704,GO:0001707,GO:0001932,GO:0001933,GO:0001934,GO:0002682,GO:0002683,GO:0002694,GO:0002695,GO:0003006,GO:0003008,GO:0003014,GO:0003091,GO:0003674,GO:0004857,GO:0004860,GO:0004862,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005813,GO:0005815,GO:0005829,GO:0005856,GO:0005886,GO:0005929,GO:0005952,GO:0006355,GO:0006357,GO:0006464,GO:0006468,GO:0006469,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0007010,GO:0007015,GO:0007017,GO:0007049,GO:0007143,GO:0007154,GO:0007162,GO:0007163,GO:0007165,GO:0007267,GO:0007268,GO:0007274,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007308,GO:0007309,GO:0007369,GO:0007389,GO:0007498,GO:0007507,GO:0007591,GO:0007596,GO:0007599,GO:0007610,GO:0007611,GO:0007612,GO:0007613,GO:0007635,GO:0008103,GO:0008150,GO:0008152,GO:0008283,GO:0008285,GO:0008306,GO:0008355,GO:0008603,GO:0009611,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009798,GO:0009887,GO:0009888,GO:0009889,GO:0009892,GO:0009893,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0009994,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010562,GO:0010563,GO:0010564,GO:0010604,GO:0010605,GO:0010628,GO:0010639,GO:0010646,GO:0010647,GO:0010648,GO:0010721,GO:0010738,GO:0010927,GO:0010948,GO:0014706,GO:0014855,GO:0015630,GO:0016020,GO:0016043,GO:0016310,GO:0016325,GO:0017076,GO:0019207,GO:0019210,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0019887,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0019932,GO:0019933,GO:0019935,GO:0019953,GO:0021700,GO:0022402,GO:0022407,GO:0022408,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030029,GO:0030036,GO:0030104,GO:0030154,GO:0030155,GO:0030234,GO:0030239,GO:0030291,GO:0030435,GO:0030551,GO:0030552,GO:0030554,GO:0030587,GO:0030951,GO:0030952,GO:0031032,GO:0031154,GO:0031156,GO:0031285,GO:0031288,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031399,GO:0031400,GO:0031401,GO:0031588,GO:0031594,GO:0031625,GO:0032147,GO:0032268,GO:0032269,GO:0032270,GO:0032501,GO:0032502,GO:0032504,GO:0032553,GO:0032555,GO:0032559,GO:0032870,GO:0032878,GO:0032944,GO:0032945,GO:0032989,GO:0032991,GO:0033002,GO:0033043,GO:0033673,GO:0033674,GO:0033762,GO:0034199,GO:0034236,GO:0035265,GO:0035556,GO:0036094,GO:0036211,GO:0040007,GO:0040020,GO:0042048,GO:0042060,GO:0042127,GO:0042129,GO:0042130,GO:0042221,GO:0042303,GO:0042325,GO:0042326,GO:0042327,GO:0042493,GO:0042592,GO:0042692,GO:0042802,GO:0042995,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043405,GO:0043406,GO:0043408,GO:0043410,GO:0043412,GO:0043434,GO:0043549,GO:0043900,GO:0043901,GO:0043934,GO:0043949,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044389,GO:0044422,GO:0044424,GO:0044425,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0044853,GO:0045121,GO:0045202,GO:0045214,GO:0045471,GO:0045595,GO:0045596,GO:0045786,GO:0045835,GO:0045859,GO:0045860,GO:0045936,GO:0045937,GO:0046006,GO:0046007,GO:0046677,GO:0048285,GO:0048332,GO:0048468,GO:0048469,GO:0048477,GO:0048513,GO:0048518,GO:0048519,GO:0048520,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0048589,GO:0048598,GO:0048599,GO:0048609,GO:0048646,GO:0048729,GO:0048731,GO:0048738,GO:0048856,GO:0048869,GO:0048871,GO:0048878,GO:0050670,GO:0050672,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050795,GO:0050817,GO:0050863,GO:0050865,GO:0050866,GO:0050868,GO:0050877,GO:0050878,GO:0050890,GO:0050891,GO:0050896,GO:0051018,GO:0051093,GO:0051128,GO:0051129,GO:0051146,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051248,GO:0051249,GO:0051250,GO:0051252,GO:0051321,GO:0051338,GO:0051347,GO:0051348,GO:0051445,GO:0051447,GO:0051703,GO:0051704,GO:0051716,GO:0051726,GO:0051783,GO:0051784,GO:0055001,GO:0055002,GO:0055017,GO:0060038,GO:0060255,GO:0060259,GO:0060281,GO:0060283,GO:0060284,GO:0060419,GO:0060537,GO:0061061,GO:0061695,GO:0061939,GO:0065007,GO:0065008,GO:0065009,GO:0070663,GO:0070664,GO:0070887,GO:0070925,GO:0071310,GO:0071375,GO:0071377,GO:0071417,GO:0071495,GO:0071704,GO:0071840,GO:0071900,GO:0071901,GO:0071902,GO:0071944,GO:0072359,GO:0072375,GO:0080090,GO:0090036,GO:0090038,GO:0090702,GO:0097159,GO:0097305,GO:0097367,GO:0097435,GO:0097546,GO:0098589,GO:0098590,GO:0098772,GO:0098805,GO:0098857,GO:0098916,GO:0099120,GO:0099536,GO:0099537,GO:0120025,GO:0120038,GO:0140013,GO:1900193,GO:1900194,GO:1901265,GO:1901363,GO:1901564,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902494,GO:1902531,GO:1902532,GO:1902533,GO:1902911,GO:1903037,GO:1903038,GO:1903046,GO:1903429,GO:1903430,GO:1903506,GO:1903538,GO:1905879,GO:1905880,GO:1990234,GO:2000112,GO:2000114,GO:2000241,GO:2000242,GO:2000253,GO:2000479,GO:2000480,GO:2001141	-	ko:K04739	ko04910,map04910	-	-	-	ko00000,ko00001	-	-	-	RIIa,cNMP_binding
k59_31222_1	118168.MC7420_1866	2.64e-49	185.0	COG2203@1|root,COG3437@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,1G07W@1117|Cyanobacteria,1H781@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_1373707_1	446466.Cfla_1352	2.73e-165	476.0	COG0488@1|root,COG0488@2|Bacteria,2GKBQ@201174|Actinobacteria,4F1R2@85016|Cellulomonadaceae	201174|Actinobacteria	S	ABC transporter	yjjK	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
k59_783432_1	748280.NH8B_3602	7.36e-41	147.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,2KPNZ@206351|Neisseriales	206351|Neisseriales	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_94266_1	1323663.AROI01000051_gene3988	2.16e-48	164.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_975138_2	314230.DSM3645_09692	1.41e-12	69.7	COG1595@1|root,COG1595@2|Bacteria,2J08Y@203682|Planctomycetes	203682|Planctomycetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1607776_1	446469.Sked_23760	1.31e-98	299.0	COG1228@1|root,COG1228@2|Bacteria,2GKRZ@201174|Actinobacteria	201174|Actinobacteria	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1549654_1	1123399.AQVE01000004_gene2538	1.8e-83	263.0	COG1100@1|root,COG1100@2|Bacteria,1R1W9@1224|Proteobacteria,1SK3H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF697,MMR_HSR1
k59_916078_1	471853.Bcav_2740	1.43e-16	79.0	2E4AX@1|root,32Z6K@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF2017)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2017
k59_1263264_1	1123518.ARWI01000001_gene1764	3.89e-103	327.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,45ZZB@72273|Thiotrichales	72273|Thiotrichales	P	Cation transporter/ATPase, N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_94289_1	388051.AUFE01000005_gene1136	1e-108	318.0	COG1741@1|root,COG1741@2|Bacteria,1MVSW@1224|Proteobacteria,2VHPA@28216|Betaproteobacteria,1K0N7@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the pirin family	yhhW_2	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
k59_94289_2	1245469.S58_51940	9.13e-06	47.4	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2U0D4@28211|Alphaproteobacteria,3JVK2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_434736_1	485915.Dret_0751	2.68e-74	235.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2WJAZ@28221|Deltaproteobacteria,2M838@213115|Desulfovibrionales	28221|Deltaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_728485_1	398525.KB900701_gene4140	4.81e-11	62.0	COG1226@1|root,32YV7@2|Bacteria,1N7MV@1224|Proteobacteria,2U76Q@28211|Alphaproteobacteria,3JYY2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
k59_728485_2	189753.AXAS01000062_gene8434	6.74e-42	155.0	COG1289@1|root,COG1289@2|Bacteria,1Q5JG@1224|Proteobacteria,2VBX6@28211|Alphaproteobacteria,3K2KA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Aromatic acid exporter family member 1	-	-	-	-	-	-	-	-	-	-	-	-	FUSC
k59_1198806_1	395493.BegalDRAFT_2600	5.5e-66	206.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,4601G@72273|Thiotrichales	72273|Thiotrichales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_1198806_2	28258.KP05_11865	6.56e-10	58.9	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1XH9U@135619|Oceanospirillales	135619|Oceanospirillales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_1327368_1	1121405.dsmv_1229	5.49e-120	347.0	COG0528@1|root,COG0528@2|Bacteria,1R19J@1224|Proteobacteria,42PME@68525|delta/epsilon subdivisions,2WJMW@28221|Deltaproteobacteria,2MJEX@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Amino acid kinase family	mosB	-	-	ko:K00947	-	-	-	-	ko00000	-	-	-	AA_kinase
k59_783448_1	765912.Thimo_3025	4.27e-24	100.0	COG2710@1|root,COG2710@2|Bacteria,1MVP0@1224|Proteobacteria,1RR8R@1236|Gammaproteobacteria,1WW6S@135613|Chromatiales	135613|Chromatiales	F	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex	bchN	-	1.3.7.7	ko:K04038	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06282	RC01008	ko00000,ko00001,ko01000	-	-	-	Oxidored_nitro
k59_783448_2	743836.AYNA01000017_gene2735	4.48e-58	185.0	294R4@1|root,2ZS4D@2|Bacteria,1RDGM@1224|Proteobacteria,2U71V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	2-vinyl bacteriochlorophyllide hydratase	bchF	GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015994,GO:0015995,GO:0018130,GO:0019438,GO:0030493,GO:0030494,GO:0033013,GO:0033014,GO:0034641,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.165	ko:K11336	ko00860,ko01110,map00860,map01110	-	R09054,R09059	RC02412	ko00000,ko00001,ko01000	-	-	-	BCHF
k59_1607789_1	1415778.JQMM01000001_gene1963	8.34e-05	49.7	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1J4XQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_1855662_1	1001585.MDS_1585	1.14e-18	89.4	COG2267@1|root,COG2267@2|Bacteria,1QTZP@1224|Proteobacteria,1RPB9@1236|Gammaproteobacteria,1YHC9@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
k59_1089187_1	314345.SPV1_06999	3.5e-81	255.0	COG2367@1|root,COG2367@2|Bacteria,1R4Y9@1224|Proteobacteria	1224|Proteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase2
k59_141765_1	471853.Bcav_2744	6.91e-38	129.0	2CAFG@1|root,32RRB@2|Bacteria,2IQ98@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3039)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3039
k59_141765_2	1074488.AGBX01000007_gene1971	1.53e-33	129.0	COG1061@1|root,COG1061@2|Bacteria,2GIU5@201174|Actinobacteria,4FBZ4@85020|Dermabacteraceae	201174|Actinobacteria	L	Type III restriction enzyme, res subunit	sdrA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ResIII
k59_670952_1	886293.Sinac_3902	1.7e-53	182.0	COG0438@1|root,COG0438@2|Bacteria,2J2SD@203682|Planctomycetes	203682|Planctomycetes	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4
k59_1199751_1	661367.LLO_2911	9.62e-56	185.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,1JF9E@118969|Legionellales	118969|Legionellales	L	Transposase IS116/IS110/IS902 family	-	GO:0003674,GO:0003824,GO:0004803,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0032196,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_976948_1	1232683.ADIMK_3980	3.8e-76	239.0	COG1493@1|root,COG1493@2|Bacteria,1R0JS@1224|Proteobacteria,1T2N5@1236|Gammaproteobacteria,46A1F@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	HPr kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_494495_1	269799.Gmet_0933	3.77e-05	47.8	COG2304@1|root,COG2373@1|root,COG3391@1|root,COG2304@2|Bacteria,COG2373@2|Bacteria,COG3391@2|Bacteria,1QU09@1224|Proteobacteria	1224|Proteobacteria	M	regulator of chromosome condensation, RCC1	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Cadherin,He_PIG,RHS_repeat
k59_1090160_1	953739.SVEN_4465	5.35e-17	84.3	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2GM09@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_1857451_1	1261545.MBE-HAL_2150	2.01e-08	56.6	COG1171@1|root,arCOG01431@2157|Archaea,2XT4W@28890|Euryarchaeota,23SNZ@183963|Halobacteria	183963|Halobacteria	E	Threonine dehydratase	ilvA1	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_4,PALP
k59_1857451_2	883.DvMF_0185	5.79e-74	230.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MRV@68525|delta/epsilon subdivisions,2WK9C@28221|Deltaproteobacteria,2M8SQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit	porB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
k59_318773_2	399741.Spro_1932	1.74e-42	154.0	COG3104@1|root,COG3104@2|Bacteria,1QXBE@1224|Proteobacteria,1RNVV@1236|Gammaproteobacteria,401XX@613|Serratia	1236|Gammaproteobacteria	E	amino acid peptide transporter	ydgR	-	-	ko:K03305,ko:K06218	-	-	-	-	ko00000,ko02048	2.A.17	-	-	MFS_1,PTR2
k59_1727177_1	1122603.ATVI01000009_gene2520	2.69e-29	113.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,1RYD7@1236|Gammaproteobacteria,1X3H9@135614|Xanthomonadales	135614|Xanthomonadales	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
k59_1727177_2	1121035.AUCH01000017_gene2243	2.85e-34	126.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2VIUV@28216|Betaproteobacteria,2KV37@206389|Rhodocyclales	206389|Rhodocyclales	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
k59_1498667_1	472759.Nhal_2913	1.02e-142	430.0	28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,1RN0X@1236|Gammaproteobacteria,1X03G@135613|Chromatiales	135613|Chromatiales	G	Fatty acid cis/trans isomerase (CTI)	-	-	-	-	-	-	-	-	-	-	-	-	CTI
k59_1434850_1	882.DVU_0999	6.96e-20	92.4	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,42MVQ@68525|delta/epsilon subdivisions,2WKBG@28221|Deltaproteobacteria,2M7VH@213115|Desulfovibrionales	28221|Deltaproteobacteria	CO	PFAM cytochrome c biogenesis protein transmembrane region	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin,Thioredoxin_7
k59_917885_2	857087.Metme_2773	1.95e-87	261.0	COG4567@1|root,COG4567@2|Bacteria,1RD7J@1224|Proteobacteria,1S3PE@1236|Gammaproteobacteria,1XE1Z@135618|Methylococcales	135618|Methylococcales	T	response regulator	-	-	-	ko:K15012	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg
k59_917885_3	1121940.AUDZ01000005_gene1902	1.63e-07	52.8	COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,1RMH4@1236|Gammaproteobacteria,1XH8P@135619|Oceanospirillales	135619|Oceanospirillales	T	Histidine kinase	-	-	2.7.13.3	ko:K15011	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c
k59_389578_1	240016.ABIZ01000001_gene5361	3.38e-34	131.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
k59_389583_1	330214.NIDE2415	4.9e-28	116.0	COG0248@1|root,COG2206@1|root,COG0248@2|Bacteria,COG2206@2|Bacteria,3J0K5@40117|Nitrospirae	2|Bacteria	FP	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	ppx	-	3.6.1.11,3.6.1.40	ko:K01524,ko:K07012	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000,ko02048	-	-	-	HD,Helicase_C,Ppx-GppA,Response_reg
k59_1137638_1	1123368.AUIS01000003_gene1591	5.75e-40	147.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,2NCE5@225057|Acidithiobacillales	225057|Acidithiobacillales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1857472_1	471853.Bcav_2427	1.15e-70	223.0	COG2047@1|root,COG2047@2|Bacteria,2GK8I@201174|Actinobacteria	201174|Actinobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
k59_976982_1	452637.Oter_1466	6.83e-95	299.0	COG0243@1|root,COG0243@2|Bacteria,46U1H@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1019207_1	292564.Cyagr_2675	1.63e-94	298.0	COG3119@1|root,COG3119@2|Bacteria,1G22U@1117|Cyanobacteria,22RRC@167375|Cyanobium	1117|Cyanobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_917900_1	1187848.AJYQ01000008_gene535	3.29e-33	129.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,1RQ31@1236|Gammaproteobacteria,1XV2J@135623|Vibrionales	135623|Vibrionales	E	COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_1608784_1	1049564.TevJSym_an00690	5.96e-14	78.6	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,1J531@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	M COG4775 Outer membrane protein protective antigen OMA87	tamA	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,POTRA_TamA_1
k59_1199770_2	247490.KSU1_C1009	7.19e-76	241.0	COG0294@1|root,COG0294@2|Bacteria,2IYYU@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
k59_1669720_1	519989.ECTPHS_06232	1.02e-98	307.0	COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1WWFZ@135613|Chromatiales	135613|Chromatiales	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase
k59_1434868_1	471852.Tcur_3087	6.27e-72	226.0	COG0667@1|root,COG0667@2|Bacteria,2GMT5@201174|Actinobacteria,4EG7B@85012|Streptosporangiales	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1857490_1	670292.JH26_15450	4.15e-64	219.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,1JR3I@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07239	-	-	-	-	ko00000	2.A.6.1	-	-	ACR_tran
k59_273098_1	314278.NB231_10523	4.04e-92	280.0	COG1980@1|root,COG1980@2|Bacteria,1MXM7@1224|Proteobacteria,1SKUG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	-	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
k59_611846_1	357804.Ping_0983	9.33e-184	533.0	COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,1RPG4@1236|Gammaproteobacteria,2QHB3@267894|Psychromonadaceae	1236|Gammaproteobacteria	C	Monomeric isocitrate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	IDH
k59_1498686_1	349124.Hhal_2328	9.06e-44	150.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1S610@1236|Gammaproteobacteria,1WY2S@135613|Chromatiales	135613|Chromatiales	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate	tsaC	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
k59_318799_1	384765.SIAM614_27133	6.56e-07	50.8	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane protein (homolog of Drosophila rhomboid)	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
k59_611848_2	261292.Nit79A3_0372	1.78e-41	145.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2VJBW@28216|Betaproteobacteria,371MG@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_1498689_1	870187.Thini_4176	3.99e-110	337.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,45ZS9@72273|Thiotrichales	72273|Thiotrichales	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_784308_1	1415780.JPOG01000001_gene875	9.09e-97	312.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X5MD@135614|Xanthomonadales	135614|Xanthomonadales	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_389648_1	452637.Oter_3478	1.25e-32	123.0	COG0059@1|root,COG0059@2|Bacteria,46SI2@74201|Verrucomicrobia,3K7PK@414999|Opitutae	74201|Verrucomicrobia	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
k59_1784946_1	187272.Mlg_0427	4.78e-37	129.0	COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,1S3PQ@1236|Gammaproteobacteria,1WXC4@135613|Chromatiales	135613|Chromatiales	L	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
k59_1784946_2	1249627.D779_1218	4.93e-11	63.5	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1WWDE@135613|Chromatiales	135613|Chromatiales	T	Belongs to the PEP-utilizing enzyme family	-	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_389655_2	572477.Alvin_0201	7.18e-51	165.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria,1WYAH@135613|Chromatiales	135613|Chromatiales	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
k59_389655_3	1049564.TevJSym_bn00100	1.5e-20	86.3	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1J62V@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	yqgE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_917962_1	367299.JOEE01000002_gene2356	8.74e-73	222.0	COG1045@1|root,COG1045@2|Bacteria,2IHW5@201174|Actinobacteria,4FGJA@85021|Intrasporangiaceae	201174|Actinobacteria	E	Serine acetyltransferase	cysE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
k59_39821_2	765913.ThidrDRAFT_3178	6.28e-82	251.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1WW7F@135613|Chromatiales	135613|Chromatiales	EP	PFAM Binding-protein-dependent transport	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_611868_1	875328.JDM601_0674	1.69e-18	79.0	2DS09@1|root,33DY5@2|Bacteria,2IR3C@201174|Actinobacteria,23AWZ@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1374774_1	1449351.RISW2_09190	3.24e-67	205.0	COG0309@1|root,COG0309@2|Bacteria,1RDJ4@1224|Proteobacteria,2U7HE@28211|Alphaproteobacteria,4KNVZ@93682|Roseivivax	28211|Alphaproteobacteria	O	Transposase, IS4	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2
k59_1374774_2	1449351.RISW2_09195	9.01e-72	216.0	COG3293@1|root,COG3293@2|Bacteria,1RDDI@1224|Proteobacteria,2U7E3@28211|Alphaproteobacteria,4KMT2@93682|Roseivivax	28211|Alphaproteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_1857559_1	1384056.N787_10150	2.36e-46	162.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1X349@135614|Xanthomonadales	135614|Xanthomonadales	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
k59_1669754_1	1485544.JQKP01000011_gene736	9.2e-136	408.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,44V2C@713636|Nitrosomonadales	28216|Betaproteobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
k59_1669754_2	1452718.JBOY01000135_gene1467	5.35e-100	296.0	COG0819@1|root,COG0819@2|Bacteria,1MVA0@1224|Proteobacteria,1RSHF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Long-chain fatty acid--CoA ligase	-	-	-	-	-	-	-	-	-	-	-	-	Haem_oxygenas_2
k59_1669754_3	1114970.PSF113_4132	6.1e-11	64.7	COG1028@1|root,COG1028@2|Bacteria,1NTI2@1224|Proteobacteria,1S2P1@1236|Gammaproteobacteria,1YPXV@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_977070_1	66692.ABC1222	8.61e-05	46.2	COG0385@1|root,COG0385@2|Bacteria,1TP85@1239|Firmicutes,4HBG6@91061|Bacilli,1ZB6V@1386|Bacillus	91061|Bacilli	S	-transporter	yocS	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	iYO844.BSU19350	SBF
k59_977070_2	316055.RPE_3199	3.54e-50	160.0	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
k59_1199821_1	395493.BegalDRAFT_3517	3.89e-32	123.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,45ZPH@72273|Thiotrichales	72273|Thiotrichales	H	PFAM aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1199821_2	1033802.SSPSH_001157	1.35e-05	48.1	COG0586@1|root,COG0586@2|Bacteria,1R0F3@1224|Proteobacteria,1RPDS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	membrane-associated protein	lssY	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	LssY_C,PAP2,SNARE_assoc
k59_1374779_1	1283300.ATXB01000001_gene2439	1.13e-106	320.0	COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,1RMRB@1236|Gammaproteobacteria,1XEA0@135618|Methylococcales	135618|Methylococcales	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
k59_39841_1	1042377.AFPJ01000036_gene1233	1.36e-73	238.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_494570_1	338963.Pcar_1589	1.47e-21	96.7	COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,42QRA@68525|delta/epsilon subdivisions,2WN1V@28221|Deltaproteobacteria,43UE5@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	beta-lactamase domain protein	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
k59_1199826_1	228410.NE2408	1.38e-36	142.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,2VHKP@28216|Betaproteobacteria,3720Z@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Competence protein ComEC Rec2	comA	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_142823_1	743718.Isova_1428	2.54e-13	71.2	COG0339@1|root,COG0339@2|Bacteria,2GM2Z@201174|Actinobacteria,4F49N@85017|Promicromonosporaceae	201174|Actinobacteria	E	Peptidase family M3	dcp	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_142823_2	67356.KL575587_gene5864	6.67e-06	49.7	COG1670@1|root,COG1670@2|Bacteria,2I8QA@201174|Actinobacteria	201174|Actinobacteria	J	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_735648_1	1286631.X805_07670	0.000132	48.9	COG2304@1|root,COG2373@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2373@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VKA9@28216|Betaproteobacteria,1KK67@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	TIGRFAM outer membrane adhesin like proteiin	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4347,He_PIG,HemolysinCabind,VWA_2
k59_399370_1	1121403.AUCV01000025_gene2290	1.44e-75	239.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NK7@68525|delta/epsilon subdivisions,2WKTV@28221|Deltaproteobacteria,2MN13@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_399370_2	177439.DP1202	4.36e-15	75.1	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,2MHX9@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_105853_1	471853.Bcav_1375	1.35e-127	390.0	COG0272@1|root,COG0272@2|Bacteria,2GJUY@201174|Actinobacteria	201174|Actinobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
k59_105853_2	935839.JAGJ01000002_gene687	2.44e-46	162.0	COG0482@1|root,COG0482@2|Bacteria,2GIUQ@201174|Actinobacteria,4F45R@85017|Promicromonosporaceae	201174|Actinobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_927782_1	796620.VIBC2010_05404	4.68e-19	87.4	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1RNVK@1236|Gammaproteobacteria,1XTSA@135623|Vibrionales	135623|Vibrionales	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA/msrB	GO:0003674,GO:0003824,GO:0008113,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016667,GO:0016671,GO:0044419,GO:0051704,GO:0055114	1.8.4.11,1.8.4.12	ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
k59_500361_1	1120956.JHZK01000002_gene850	7.06e-49	162.0	COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,2U1JG@28211|Alphaproteobacteria,1JP1Q@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function DUF45	MA20_23375	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
k59_441694_1	1366050.N234_07100	2.6e-57	187.0	2CCCK@1|root,2Z7UH@2|Bacteria,1R3SV@1224|Proteobacteria,2W0ZB@28216|Betaproteobacteria,1K2ZK@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1270944_1	350054.Mflv_3959	1.2e-53	183.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,2351D@1762|Mycobacteriaceae	201174|Actinobacteria	L	DEAD DEAH box helicase	rhlE1	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
k59_1205536_1	225117.XP_009350065.1	2.9e-11	63.9	COG0099@1|root,KOG3311@2759|Eukaryota	2759|Eukaryota	J	rRNA binding	-	GO:0000313,GO:0000314,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005763,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0031974,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0071840,GO:0098798,GO:0140053,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_1205536_2	497964.CfE428DRAFT_0509	5.02e-32	119.0	COG0100@1|root,COG0100@2|Bacteria,46STW@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
k59_280901_1	1192034.CAP_6549	5.29e-73	239.0	COG0517@1|root,COG0517@2|Bacteria,1QZT1@1224|Proteobacteria,43CN4@68525|delta/epsilon subdivisions,2X7VC@28221|Deltaproteobacteria,2Z3IG@29|Myxococcales	28221|Deltaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_852688_2	671143.DAMO_3032	4.75e-36	130.0	COG0861@1|root,COG0861@2|Bacteria,2NQFQ@2323|unclassified Bacteria	2|Bacteria	P	Integral membrane protein TerC family	terC	-	-	-	-	-	-	-	-	-	-	-	TerC
k59_789094_1	765912.Thimo_2557	0.000234	42.7	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1WVVC@135613|Chromatiales	135613|Chromatiales	F	TIGRFAM dihydroorotase, multifunctional complex type	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_789094_2	323261.Noc_0365	6.61e-71	223.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,1WWU0@135613|Chromatiales	135613|Chromatiales	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_399416_1	497964.CfE428DRAFT_3010	5.26e-65	223.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,46TRH@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Tricorn protease PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
k59_617541_1	420324.KI911934_gene172	2.76e-140	408.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JXEF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_852692_1	1232410.KI421420_gene3185	2.07e-79	249.0	COG5002@1|root,COG5002@2|Bacteria,1QU7C@1224|Proteobacteria,439YG@68525|delta/epsilon subdivisions,2WUBB@28221|Deltaproteobacteria,43UAD@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_105887_1	420246.GTNG_2284	2.26e-30	117.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,4H9QY@91061|Bacilli,1WFTK@129337|Geobacillus	91061|Bacilli	C	Electron transfer flavoprotein domain	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_1270958_1	314345.SPV1_06994	1.17e-43	156.0	COG2367@1|root,COG2367@2|Bacteria,1R6KF@1224|Proteobacteria	1224|Proteobacteria	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
k59_1789893_2	743299.Acife_2802	1.02e-56	188.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,2NC14@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
k59_1505323_1	158190.SpiGrapes_0038	1.83e-55	187.0	COG0498@1|root,COG0498@2|Bacteria,2J63T@203691|Spirochaetes	203691|Spirochaetes	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
k59_207329_1	42565.FP66_06770	2.12e-33	131.0	COG2334@1|root,COG2334@2|Bacteria,1QV5C@1224|Proteobacteria,1T293@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Ecdysteroid kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_1505324_1	1121405.dsmv_1133	4.26e-68	224.0	COG5002@1|root,COG5002@2|Bacteria,1R6WE@1224|Proteobacteria,42P99@68525|delta/epsilon subdivisions,2WK5E@28221|Deltaproteobacteria,2MPS4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K11383	ko02020,map02020	M00505	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	4HB_MCP_1,HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8
k59_986921_1	443906.CMM_1993	6.93e-46	156.0	COG2094@1|root,COG2094@2|Bacteria,2GNW1@201174|Actinobacteria,4FNW5@85023|Microbacteriaceae	201174|Actinobacteria	L	Belongs to the DNA glycosylase MPG family	alkA	GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
k59_1339174_1	1123065.ATWL01000005_gene1380	1.64e-267	746.0	COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria	201174|Actinobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iNJ661.Rv3436c	GATase_6,SIS
k59_1789907_1	765911.Thivi_1037	1.97e-67	217.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1WW48@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_280946_1	34506.g1763	6.82e-75	255.0	2D1GV@1|root,2SI2U@2759|Eukaryota,3AIRA@33154|Opisthokonta,3BYFA@33208|Metazoa,3DE5D@33213|Bilateria	33208|Metazoa	S	NQRA C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	NQRA,NQRA_SLBB
k59_399456_1	187272.Mlg_2420	2.52e-19	85.9	COG3065@1|root,COG3065@2|Bacteria,1MZ8C@1224|Proteobacteria,1S9UB@1236|Gammaproteobacteria,1WYVZ@135613|Chromatiales	135613|Chromatiales	M	PFAM Outer membrane lipoprotein Slp	-	-	-	ko:K07285	-	-	-	-	ko00000	-	-	-	Slp
k59_1440686_1	1515746.HR45_16840	1.29e-35	130.0	COG2962@1|root,COG2962@2|Bacteria,1MX5G@1224|Proteobacteria,1RMAC@1236|Gammaproteobacteria,2Q8GI@267890|Shewanellaceae	1236|Gammaproteobacteria	S	TIGRFAM RarD protein, DMT superfamily transporter	rarD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0044425,GO:0044464,GO:0071944	-	ko:K05786	-	-	-	-	ko00000,ko02000	2.A.7.7	-	-	EamA
k59_1440686_2	1384056.N787_13120	6.42e-17	80.5	COG0083@1|root,COG0083@2|Bacteria,1MW8I@1224|Proteobacteria,1RMYR@1236|Gammaproteobacteria,1X3BS@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_1270995_1	870187.Thini_3397	9.01e-69	220.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,45ZMS@72273|Thiotrichales	72273|Thiotrichales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_399477_1	1172188.KB911826_gene149	8.3e-66	218.0	COG1233@1|root,COG1233@2|Bacteria,2HX8Z@201174|Actinobacteria,4FFVH@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_1096620_1	68570.DC74_6972	1.21e-25	106.0	COG0583@1|root,COG0583@2|Bacteria,2GMPE@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	LysR_substrate
k59_1867457_1	717785.HYPMC_3322	7.65e-83	261.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	2.7.7.49	ko:K00986,ko:K07497	-	-	-	-	ko00000,ko01000	-	-	-	HTH_32,rve
k59_324601_1	1001240.GY21_04280	2.57e-27	102.0	2DQBC@1|root,335SY@2|Bacteria,2I0SM@201174|Actinobacteria,4FSZ2@85023|Microbacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1732991_1	631362.Thi970DRAFT_04194	1.03e-115	352.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1WWSQ@135613|Chromatiales	135613|Chromatiales	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_1675682_1	886293.Sinac_5687	3.11e-114	335.0	COG3385@1|root,COG3385@2|Bacteria,2J0FA@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_1096637_1	314285.KT71_16006	1.21e-100	314.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1J81W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	ATP-dependent Clp protease ATP-binding subunit ClpA	clpA	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_105982_1	367299.JOEE01000003_gene2919	6.56e-43	152.0	COG3920@1|root,COG3920@2|Bacteria,2GKMP@201174|Actinobacteria,4FE8I@85021|Intrasporangiaceae	201174|Actinobacteria	T	Histidine kinase	pdtaS	GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K00936	-	M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,H_kinase_N,HisKA_2,PAS_4
k59_105982_2	935839.JAGJ01000002_gene863	1.84e-38	129.0	2DMIE@1|root,32RSG@2|Bacteria,2IQCG@201174|Actinobacteria,4F4R6@85017|Promicromonosporaceae	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB	GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
k59_1732996_1	713586.KB900536_gene1605	7.03e-14	71.6	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,1WWKS@135613|Chromatiales	135613|Chromatiales	M	Involved in formation and maintenance of cell shape	-	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
k59_49724_1	471853.Bcav_1638	2.55e-57	186.0	COG0406@1|root,COG0406@2|Bacteria,2GJYU@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the phosphoglycerate mutase family	gpmB	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237	3.1.3.85,5.4.2.11	ko:K01834,ko:K22306	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
k59_501261_1	1278073.MYSTI_02808	1.95e-118	352.0	COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria	1224|Proteobacteria	S	major pilin protein fima	MA20_16755	-	-	-	-	-	-	-	-	-	-	-	DUF1028
k59_501261_2	1123368.AUIS01000003_gene1844	8.21e-11	63.5	2C7AT@1|root,338A4@2|Bacteria,1NF74@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_929438_1	1117318.PRUB_01314	7.23e-24	94.4	COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,1S3PW@1236|Gammaproteobacteria,2Q2J9@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	Lipocalin	blc	GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033554,GO:0044462,GO:0044464,GO:0050896,GO:0051716,GO:0071944	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
k59_208258_1	717785.HYPMC_0143	2.27e-30	120.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Resolvase	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
k59_325494_1	472759.Nhal_2016	1.48e-137	398.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1WX16@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_1097693_2	1197706.AKKK01000022_gene2267	8.15e-36	131.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria,1W8IR@1268|Micrococcaceae	201174|Actinobacteria	P	Belongs to the bacterial solute-binding protein 9 family	mntC	-	-	ko:K09818,ko:K11601	ko02010,ko02020,map02010,map02020	M00243,M00316	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.1	-	-	ZnuA
k59_282472_1	933262.AXAM01000039_gene1163	2.29e-41	152.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,2MHKJ@213118|Desulfobacterales	28221|Deltaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_501275_1	999141.GME_12900	1.89e-32	119.0	COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,1RNXB@1236|Gammaproteobacteria,1XK7W@135619|Oceanospirillales	135619|Oceanospirillales	I	Coenzyme A transferase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_trans
k59_501275_2	1121918.ARWE01000001_gene553	3.11e-57	184.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,42M0S@68525|delta/epsilon subdivisions,2WITR@28221|Deltaproteobacteria,43U8F@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	ABC transporter	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
k59_1340812_1	257310.BB2597	6.75e-12	67.8	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,3T1IK@506|Alcaligenaceae	28216|Betaproteobacteria	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
k59_988614_1	998674.ATTE01000001_gene1291	2.73e-93	291.0	COG0569@1|root,COG2985@1|root,COG0569@2|Bacteria,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,1RQ47@1236|Gammaproteobacteria,462AG@72273|Thiotrichales	72273|Thiotrichales	P	Predicted Permease Membrane Region	-	-	-	-	-	-	-	-	-	-	-	-	Asp-Al_Ex,TrkA_C
k59_559859_1	367299.JOEE01000001_gene1870	9.58e-97	295.0	COG3004@1|root,COG3004@2|Bacteria,2GKIK@201174|Actinobacteria,4FEBC@85021|Intrasporangiaceae	201174|Actinobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_988616_1	1184607.AUCHE_05_06090	7.22e-76	246.0	COG1882@1|root,COG1882@2|Bacteria,2GTTT@201174|Actinobacteria,4F7MD@85018|Dermatophilaceae	201174|Actinobacteria	C	Glycine radical	pflB	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
k59_1206475_1	582402.Hbal_2498	6.62e-16	80.9	COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,2TQVR@28211|Alphaproteobacteria,43XAB@69657|Hyphomonadaceae	28211|Alphaproteobacteria	L	COG0389 Nucleotidyltransferase DNA polymerase involved in DNA repair	imuB	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS,IMS_C
k59_1143447_1	479431.Namu_4851	3.82e-89	278.0	COG3039@1|root,COG3039@2|Bacteria,2HW75@201174|Actinobacteria,4EWBZ@85013|Frankiales	201174|Actinobacteria	L	PFAM transposase IS4 family protein	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1869065_1	519989.ECTPHS_00730	1.1e-33	125.0	COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,1S6X3@1236|Gammaproteobacteria,1WWFD@135613|Chromatiales	135613|Chromatiales	K	PFAM Cyclic nucleotide-binding	-	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_559864_1	243233.MCA0363	4.26e-35	136.0	COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,1RN89@1236|Gammaproteobacteria,1XEQ8@135618|Methylococcales	135618|Methylococcales	Q	MlaD protein	pqiB	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
k59_1506528_1	1121405.dsmv_1912	1.15e-58	191.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42RCI@68525|delta/epsilon subdivisions,2WMYC@28221|Deltaproteobacteria,2MJI4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein domain	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_1272199_1	236097.ADG881_1813	6.18e-34	134.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1XHCH@135619|Oceanospirillales	135619|Oceanospirillales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_282488_1	935839.JAGJ01000008_gene1715	1.27e-173	496.0	COG0263@1|root,COG0263@2|Bacteria,2GM8U@201174|Actinobacteria,4F3W9@85017|Promicromonosporaceae	201174|Actinobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
k59_149784_1	28042.GU90_14960	1.64e-14	74.3	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4E0V5@85010|Pseudonocardiales	201174|Actinobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_282499_1	331869.BAL199_01884	2.97e-37	133.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TRI8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ATPase (AAA)	MA20_01295	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
k59_1100646_1	1453501.JELR01000002_gene164	7.54e-78	239.0	COG2259@1|root,COG2259@2|Bacteria,1RBZP@1224|Proteobacteria,1S28E@1236|Gammaproteobacteria,466DA@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
k59_1027239_1	224911.27355863	4.45e-62	220.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3JVPA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF
k59_1736723_1	1380386.JIAW01000033_gene4050	1.9e-07	53.1	29VND@1|root,30H5P@2|Bacteria,2ICBQ@201174|Actinobacteria,238K3@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_504086_1	196162.Noca_4340	0.000209	48.9	COG0477@1|root,COG0477@2|Bacteria,COG2814@2|Bacteria,2GIUM@201174|Actinobacteria,4DNWW@85009|Propionibacteriales	201174|Actinobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_1560386_2	1122599.AUGR01000010_gene998	1.32e-47	157.0	COG2995@1|root,COG2995@2|Bacteria,1NA1F@1224|Proteobacteria,1SERF@1236|Gammaproteobacteria,1XQ7I@135619|Oceanospirillales	135619|Oceanospirillales	S	Paraquat-inducible protein A	-	-	-	-	-	-	-	-	-	-	-	-	PqiA
k59_1345031_1	1227739.Hsw_3987	1.16e-08	56.2	COG0006@1|root,COG0006@2|Bacteria,4NI0S@976|Bacteroidetes,47MY8@768503|Cytophagia	976|Bacteroidetes	E	Belongs to the peptidase M24B family	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
k59_1345031_2	1123401.JHYQ01000021_gene1007	1.18e-20	92.4	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,45ZU3@72273|Thiotrichales	72273|Thiotrichales	CH	Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	-	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_562655_1	883077.HMPREF9241_00001	9.85e-05	42.0	2DEPW@1|root,2ZNS6@2|Bacteria,2GWSK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_992777_1	225937.HP15_2235	5.95e-56	184.0	COG0720@1|root,COG0720@2|Bacteria,1MXVT@1224|Proteobacteria,1RN6H@1236|Gammaproteobacteria,464QP@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	COG0720 6-pyruvoyl-tetrahydropterin synthase	SO2179	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PTPS
k59_211131_1	1223410.KN050846_gene1076	4.68e-70	222.0	COG0457@1|root,COG0457@2|Bacteria,4NJ7M@976|Bacteroidetes,1I0QV@117743|Flavobacteriia	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_6,TPR_8
k59_1679358_1	1454010.JEOE01000017_gene1237	1.39e-57	201.0	COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,4F0S5@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1027277_2	1157490.EL26_12425	3e-13	70.5	COG0681@1|root,COG0681@2|Bacteria,1TRAV@1239|Firmicutes,4HCTU@91061|Bacilli,27APW@186823|Alicyclobacillaceae	91061|Bacilli	U	Belongs to the peptidase S26 family	sipS3	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_1793241_1	246197.MXAN_0998	1.4e-25	110.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,42Q14@68525|delta/epsilon subdivisions,2WJ8C@28221|Deltaproteobacteria,2YX9F@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
k59_111698_1	713586.KB900536_gene118	1.71e-144	423.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1WWJ8@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_1345052_1	631362.Thi970DRAFT_03137	4.33e-83	255.0	COG1720@1|root,COG1720@2|Bacteria,1MUF0@1224|Proteobacteria,1RPCX@1236|Gammaproteobacteria,1WWG4@135613|Chromatiales	135613|Chromatiales	S	PFAM Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
k59_1345052_2	395493.BegalDRAFT_1745	0.000242	42.7	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,460HQ@72273|Thiotrichales	72273|Thiotrichales	J	Specifically methylates the ribose of guanosine 2251 in 23S rRNA	rlmB	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
k59_328444_1	935839.JAGJ01000001_gene1048	2.22e-67	216.0	COG0673@1|root,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria,4F49F@85017|Promicromonosporaceae	201174|Actinobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
k59_53349_1	715451.ambt_04925	7.53e-17	84.0	COG0398@1|root,COG0398@2|Bacteria,1RDYV@1224|Proteobacteria	1224|Proteobacteria	S	Pfam SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_53349_2	1217720.ALOX01000036_gene2994	7.12e-72	228.0	COG0463@1|root,COG0463@2|Bacteria,1MW2G@1224|Proteobacteria,2TTR9@28211|Alphaproteobacteria,2JQI8@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
k59_53349_3	713586.KB900536_gene2613	2.17e-87	278.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales	135613|Chromatiales	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_856418_1	1049564.TevJSym_bq00090	3.1e-98	289.0	COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,1J4WI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
k59_405245_1	1525715.IX54_07270	0.000561	41.2	2EGD6@1|root,33A4Z@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
k59_992808_1	1082933.MEA186_30901	2.73e-43	164.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_445510_2	527002.yaldo0001_34440	1.33e-07	53.9	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,1RME6@1236|Gammaproteobacteria,41E4N@629|Yersinia	1236|Gammaproteobacteria	F	formate--tetrahydrofolate ligase	fhs	GO:0000096,GO:0000097,GO:0000105,GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006520,GO:0006547,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009108,GO:0009110,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0052803,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_856428_1	273068.TTE2791	4.91e-24	97.8	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,42F5R@68295|Thermoanaerobacterales	186801|Clostridia	D	PFAM Cobyrinic acid a,c-diamide synthase	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_856428_2	290315.Clim_2055	1.54e-13	72.0	COG1475@1|root,COG1475@2|Bacteria,1FDJC@1090|Chlorobi	1090|Chlorobi	K	Belongs to the ParB family	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_792844_2	414684.RC1_0681	5.73e-84	260.0	COG0811@1|root,COG0811@2|Bacteria,1NMPB@1224|Proteobacteria,2TVM9@28211|Alphaproteobacteria,2JRH9@204441|Rhodospirillales	204441|Rhodospirillales	U	TonB dependent biopolymer transporter integral cytoplasmic membrane subunit, working with ExbD	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_792844_3	388051.AUFE01000098_gene3760	3.11e-23	96.7	COG0811@1|root,COG0848@1|root,COG0811@2|Bacteria,COG0848@2|Bacteria,1NMPB@1224|Proteobacteria,2VJ4U@28216|Betaproteobacteria,1K1X0@119060|Burkholderiaceae	28216|Betaproteobacteria	U	MotA TolQ ExbB proton channel	exbB1	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_113033_1	1304865.JAGF01000001_gene593	5.68e-110	331.0	COG1061@1|root,COG1061@2|Bacteria,2GIR9@201174|Actinobacteria,4F0ZR@85016|Cellulomonadaceae	201174|Actinobacteria	L	type III restriction protein res subunit	ercc3	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
k59_1276399_1	1379281.AVAG01000054_gene557	4.14e-105	314.0	COG1260@1|root,COG1260@2|Bacteria,1N0D9@1224|Proteobacteria,42NWK@68525|delta/epsilon subdivisions,2WM2T@28221|Deltaproteobacteria,2MEGC@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
k59_740570_1	323848.Nmul_A0510	6.95e-86	270.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VZIT@28216|Betaproteobacteria,371QJ@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Trypsin	-	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_153668_2	1121875.KB907553_gene20	1.35e-78	247.0	COG5361@1|root,COG5361@2|Bacteria,4NKSK@976|Bacteroidetes,1IARY@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_563611_1	321846.PS417_08110	1.69e-42	152.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,1RMGC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
k59_563611_2	391615.ABSJ01000054_gene1465	9.6e-73	233.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1J4NS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_994015_1	796945.HMPREF1145_1342	3.38e-26	105.0	COG0745@1|root,COG0745@2|Bacteria,1TP9M@1239|Firmicutes,247TK@186801|Clostridia,2PRTX@265975|Oribacterium	186801|Clostridia	T	Response regulator receiver domain protein	phoP_1	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_153669_1	765912.Thimo_1118	9.82e-68	213.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1WWX5@135613|Chromatiales	135613|Chromatiales	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_153669_2	572477.Alvin_2693	1.16e-151	431.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1WXI2@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_54822_1	1009370.ALO_13784	3.29e-15	80.5	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,4H25A@909932|Negativicutes	909932|Negativicutes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1874656_1	1499967.BAYZ01000119_gene3216	2.08e-76	258.0	COG0574@1|root,COG0574@2|Bacteria,2NQHP@2323|unclassified Bacteria	2|Bacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_2,PPDK_N,Response_reg
k59_1146838_1	266264.Rmet_5216	4.52e-69	225.0	COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,2WBWX@28216|Betaproteobacteria,1K6U7@119060|Burkholderiaceae	28216|Betaproteobacteria	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C
k59_1146838_2	1218084.BBJK01000149_gene7523	1.32e-94	287.0	COG1075@1|root,COG1075@2|Bacteria,1NSK3@1224|Proteobacteria,2WG1G@28216|Betaproteobacteria,1KI8H@119060|Burkholderiaceae	28216|Betaproteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_113061_1	1202962.KB907158_gene3692	0.000347	42.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	pgpA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	iECSP_1301.ECSP_0485,iECUMN_1333.ECUMN_0456,iECs_1301.ECs0471,iG2583_1286.G2583_0529,iPC815.YPO3179,iZ_1308.Z0520	PgpA
k59_113061_2	1415778.JQMM01000001_gene2182	1.42e-70	225.0	COG0224@1|root,COG0224@2|Bacteria,1RIE5@1224|Proteobacteria,1S3ZW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	ATP synthase gamma subunit	-	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_1346445_1	543728.Vapar_5836	1.52e-104	315.0	COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,2VHJU@28216|Betaproteobacteria,4AB94@80864|Comamonadaceae	28216|Betaproteobacteria	L	Transposase zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_1210032_1	768671.ThimaDRAFT_4409	1.59e-48	163.0	COG0437@1|root,COG0437@2|Bacteria,1N9WY@1224|Proteobacteria,1RNHT@1236|Gammaproteobacteria,1WY71@135613|Chromatiales	135613|Chromatiales	C	4Fe-4S binding domain	-	-	-	ko:K02573	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4,Fer4_7
k59_1210032_2	94122.Shewana3_3432	2.17e-35	132.0	COG0348@1|root,COG0348@2|Bacteria,1MWR5@1224|Proteobacteria,1RQ1I@1236|Gammaproteobacteria,2QA3R@267890|Shewanellaceae	1236|Gammaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	napH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02574	-	-	-	-	ko00000	-	-	iEcSMS35_1347.EcSMS35_2352	Fer4,Fer4_10,Fer4_5,Fer4_6
k59_212074_1	768671.ThimaDRAFT_3356	1.3e-31	119.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales	135613|Chromatiales	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
k59_212074_2	32042.PstZobell_08822	2.9e-33	122.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,1RSHS@1236|Gammaproteobacteria,1Z11B@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_0821,iECIAI1_1343.ECIAI1_0813,iECO103_1326.ECO103_0813,iECO111_1330.ECO111_0839,iECO26_1355.ECO26_0904,iECSE_1348.ECSE_0831,iECW_1372.ECW_m0833,iEKO11_1354.EKO11_3108,iEcE24377_1341.EcE24377A_0841,iSFV_1184.SFV_0761,iSSON_1240.SSON_0757,iWFL_1372.ECW_m0833,ic_1306.c0858	AAA_26
k59_1561319_1	177437.HRM2_35880	8.42e-31	115.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,42N5N@68525|delta/epsilon subdivisions,2WMJ5@28221|Deltaproteobacteria,2MHNM@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_1561319_2	1122971.BAME01000092_gene5633	2.21e-06	48.1	COG0590@1|root,COG0590@2|Bacteria,4NNJ2@976|Bacteroidetes,2FSMJ@200643|Bacteroidia,22XW1@171551|Porphyromonadaceae	976|Bacteroidetes	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
k59_406625_1	330214.NIDE3408	1.81e-86	276.0	COG0855@1|root,COG0855@2|Bacteria	2|Bacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	iJN746.PP_5217	PP_kinase,PP_kinase_C,PP_kinase_N
k59_113087_1	1479237.JMLY01000001_gene2159	3.25e-09	63.9	COG1426@1|root,COG1426@2|Bacteria,1N240@1224|Proteobacteria,1RQMV@1236|Gammaproteobacteria,4689I@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	rodZ	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
k59_1210043_1	243233.MCA2171	1.8e-16	84.7	2ECB1@1|root,3369C@2|Bacteria,1NX58@1224|Proteobacteria,1SRD4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1619534_1	1206730.BAGA01000064_gene2355	2.35e-08	61.2	COG2230@1|root,COG2230@2|Bacteria,2IA12@201174|Actinobacteria,4FZ5I@85025|Nocardiaceae	201174|Actinobacteria	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_287744_1	913325.N799_00765	1.14e-91	281.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RPI1@1236|Gammaproteobacteria,1X3FF@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	mexA	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD,HlyD_D23
k59_1737725_1	933262.AXAM01000023_gene643	1.9e-77	250.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria,2MJ0A@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_1874704_1	1121924.ATWH01000004_gene2299	2.18e-10	67.4	COG5002@1|root,COG5002@2|Bacteria,2I2DU@201174|Actinobacteria,4FTKY@85023|Microbacteriaceae	201174|Actinobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_563657_1	1095767.CAHD01000241_gene1831	1.5e-85	261.0	COG0473@1|root,COG0473@2|Bacteria,2GK44@201174|Actinobacteria,4F23E@85016|Cellulomonadaceae	201174|Actinobacteria	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_1794100_1	156889.Mmc1_3385	9.16e-82	268.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_994077_1	439235.Dalk_4332	5.61e-113	339.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,2MIMB@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1445297_1	930169.B5T_02239	8.45e-99	303.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNN9@1236|Gammaproteobacteria,1XIW9@135619|Oceanospirillales	135619|Oceanospirillales	OU	peptidase	sohB	-	-	ko:K04774	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49,Peptidase_S49_N
k59_1874719_1	1306174.JODP01000001_gene5348	1.06e-39	139.0	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria	201174|Actinobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_1874719_2	76636.JOEC01000006_gene57	1.24e-26	103.0	COG0251@1|root,COG0251@2|Bacteria,2IHNE@201174|Actinobacteria,4FNTP@85023|Microbacteriaceae	201174|Actinobacteria	J	YjgF/chorismate_mutase-like, putative endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
k59_1794101_1	393595.ABO_0815	8.23e-47	166.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1XICI@135619|Oceanospirillales	135619|Oceanospirillales	O	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04691,ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
k59_54901_1	96561.Dole_0581	1.29e-36	131.0	COG1433@1|root,COG1433@2|Bacteria,1RHT9@1224|Proteobacteria,42T9R@68525|delta/epsilon subdivisions,2WPV5@28221|Deltaproteobacteria,2MK8D@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Dinitrogenase iron-molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
k59_329450_1	713587.THITH_07000	2.94e-24	93.2	2DYJZ@1|root,34A4Y@2|Bacteria,1P1QB@1224|Proteobacteria,1ST0Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_329450_2	1496688.ER33_10355	2.79e-17	78.2	COG1765@1|root,COG1765@2|Bacteria,1GAGW@1117|Cyanobacteria	1117|Cyanobacteria	O	PFAM OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
k59_1737738_1	10224.XP_006823892.1	6.49e-83	261.0	2D57X@1|root,2SXP9@2759|Eukaryota,3AFPT@33154|Opisthokonta,3BZ8I@33208|Metazoa	10224.XP_006823892.1|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1210063_1	472759.Nhal_2813	2.91e-33	127.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1WW6K@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_291984_1	2340.JV46_03580	6.88e-164	479.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J8SM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Citrate transporter	sac1	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_1741225_1	768671.ThimaDRAFT_0223	5.03e-88	273.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,1RN1W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
k59_567014_1	935839.JAGJ01000006_gene3427	4.84e-69	224.0	COG0138@1|root,COG0138@2|Bacteria,2GJWU@201174|Actinobacteria,4F4A6@85017|Promicromonosporaceae	201174|Actinobacteria	F	AICARFT/IMPCHase bienzyme	purH	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_567014_2	446469.Sked_28120	1.31e-82	251.0	COG0299@1|root,COG0299@2|Bacteria,2H8QB@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0034641,GO:0042558,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0071704,GO:1901360,GO:1901564	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
k59_291993_1	189753.AXAS01000001_gene3735	3.5e-172	498.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TQJR@28211|Alphaproteobacteria,3JV4X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Acetyl-coenzyme A synthetase N-terminus	prpE	GO:0003674,GO:0003824,GO:0003987,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0017144,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046950,GO:0046951,GO:0070013,GO:0071704,GO:1901568,GO:1901570,GO:1901576,GO:1902224	6.2.1.1,6.2.1.17	ko:K01895,ko:K01908	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1105455_1	1207063.P24_01450	1.89e-16	78.6	COG2180@1|root,COG2180@2|Bacteria,1MY4E@1224|Proteobacteria,2U19T@28211|Alphaproteobacteria,2JSPY@204441|Rhodospirillales	204441|Rhodospirillales	C	Nitrate reductase delta subunit	-	-	-	ko:K00373	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Nitrate_red_del
k59_1105455_2	1044.EH31_11005	2.19e-26	103.0	COG2181@1|root,COG2181@2|Bacteria,1MXGZ@1224|Proteobacteria,2TTDB@28211|Alphaproteobacteria,2K4E1@204457|Sphingomonadales	204457|Sphingomonadales	C	Nitrate reductase gamma subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_gam
k59_508471_1	1175306.GWL_39530	1.27e-27	109.0	COG3618@1|root,COG3618@2|Bacteria,1R5V9@1224|Proteobacteria,2VPT0@28216|Betaproteobacteria,476XZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_508471_2	1123367.C666_11740	2.37e-29	118.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHCV@28216|Betaproteobacteria,2KWWE@206389|Rhodocyclales	206389|Rhodocyclales	E	ABC-type dipeptide transport system, periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_508483_1	314345.SPV1_06109	6.11e-104	315.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria	1224|Proteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	atzF	-	3.5.1.54	ko:K01457	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120	-	R00005	RC02756	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_292034_1	1386089.N865_04620	6.3e-15	74.7	29VND@1|root,30H5P@2|Bacteria,2ICBQ@201174|Actinobacteria,4FHGV@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_292034_2	1120959.ATXF01000006_gene1918	1.33e-51	182.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4FMAX@85023|Microbacteriaceae	201174|Actinobacteria	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_332922_1	1125971.ASJB01000031_gene1301	1.33e-158	453.0	COG0409@1|root,COG0409@2|Bacteria,2GMHA@201174|Actinobacteria,4DYZ6@85010|Pseudonocardiales	201174|Actinobacteria	O	hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
k59_332922_2	870187.Thini_0240	1.06e-05	46.2	COG0298@1|root,COG0298@2|Bacteria,1N76Y@1224|Proteobacteria,1T0H0@1236|Gammaproteobacteria,461BU@72273|Thiotrichales	72273|Thiotrichales	O	PFAM hydrogenase expression formation protein (HUPF HYPC)	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
k59_1034067_2	1123393.KB891329_gene974	8.6e-49	163.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2VJPI@28216|Betaproteobacteria,1KSGP@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Glutamine amidotransferase class-I	-	-	-	-	-	-	-	-	-	-	-	-	GATase
k59_1034068_1	1123242.JH636435_gene1890	5.6e-29	109.0	COG0727@1|root,COG0727@2|Bacteria,2IZM1@203682|Planctomycetes	203682|Planctomycetes	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_451260_1	768671.ThimaDRAFT_2530	5.6e-78	241.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1WWT0@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_1389972_1	870187.Thini_4032	1.13e-05	47.0	2E0WU@1|root,32VAZ@2|Bacteria,1N42K@1224|Proteobacteria,1S97C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1389972_2	765911.Thivi_4072	5.84e-39	135.0	2E2DR@1|root,32XIE@2|Bacteria,1N271@1224|Proteobacteria,1SIHA@1236|Gammaproteobacteria,1X1VU@135613|Chromatiales	135613|Chromatiales	S	SseB protein N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	SseB
k59_1515715_2	396588.Tgr7_2900	1.62e-130	421.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_1623961_1	159450.NH14_30110	1.59e-18	84.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2VIME@28216|Betaproteobacteria,1JZXY@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
k59_1623961_2	526225.Gobs_4178	5.58e-21	90.1	COG0688@1|root,COG0688@2|Bacteria,2GMMF@201174|Actinobacteria,4EWEE@85013|Frankiales	201174|Actinobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
k59_568464_1	641491.DND132_0693	1.91e-89	285.0	COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,42QJC@68525|delta/epsilon subdivisions,2WPI2@28221|Deltaproteobacteria,2M9VY@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_10,TPR_16,TPR_19,TPR_4,TPR_8
k59_509990_1	1049564.TevJSym_ag01010	9.48e-46	167.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	signal transduction Histidine kinase	ntrY	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8
k59_1515730_1	196162.Noca_4918	1.02e-58	200.0	COG2197@1|root,COG2206@1|root,COG2197@2|Bacteria,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria,4DT1D@85009|Propionibacteriales	201174|Actinobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HD,HD_5
k59_796649_2	1121396.KB892941_gene3923	4.96e-38	136.0	COG1397@1|root,COG1397@2|Bacteria,1RA82@1224|Proteobacteria,42QPD@68525|delta/epsilon subdivisions,2WMNN@28221|Deltaproteobacteria,2MJI9@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
k59_1151093_1	519989.ECTPHS_05420	2.89e-28	109.0	COG1802@1|root,COG1802@2|Bacteria,1MWG2@1224|Proteobacteria,1RNYJ@1236|Gammaproteobacteria,1X2CS@135613|Chromatiales	135613|Chromatiales	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_1515734_1	590998.Celf_1429	8.56e-30	119.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,4F10W@85016|Cellulomonadaceae	201174|Actinobacteria	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
k59_1214798_1	266265.Bxe_A1418	1.19e-21	92.8	COG2267@1|root,COG2267@2|Bacteria,1NK3M@1224|Proteobacteria,2VKPD@28216|Betaproteobacteria,1KG70@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1214798_2	264198.Reut_A1329	2.76e-24	100.0	COG0683@1|root,COG0683@2|Bacteria,1MVV2@1224|Proteobacteria,2VIK5@28216|Betaproteobacteria,1KGRS@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_1107213_1	1283287.KB822577_gene3102	1.32e-136	395.0	COG1073@1|root,COG1073@2|Bacteria,2GNST@201174|Actinobacteria,4DP4F@85009|Propionibacteriales	201174|Actinobacteria	S	Prolyl oligopeptidase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	DUF1100,Peptidase_S9
k59_451295_1	1283300.ATXB01000001_gene633	2.27e-53	170.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,1XF6W@135618|Methylococcales	135618|Methylococcales	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
k59_451295_2	1203554.HMPREF1476_02446	4.68e-07	49.3	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,2VR8I@28216|Betaproteobacteria,4PQYJ@995019|Sutterellaceae	28216|Betaproteobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
k59_1151100_1	1249627.D779_0854	5.83e-80	249.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1WWZW@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_1565804_2	326427.Cagg_0521	6.03e-47	170.0	COG1668@1|root,COG1668@2|Bacteria,2G7R2@200795|Chloroflexi	200795|Chloroflexi	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_1565804_3	999425.HMPREF9186_01006	1.66e-54	184.0	COG1131@1|root,COG1131@2|Bacteria,1TPJE@1239|Firmicutes,4HB5U@91061|Bacilli	91061|Bacilli	V	ABC transporter	drrA	-	-	ko:K01990,ko:K11050	ko02010,map02010	M00254,M00298	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.130	-	-	ABC_tran,DUF4162
k59_158420_1	472759.Nhal_0505	4.51e-64	204.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1WX43@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
k59_568482_1	857087.Metme_3494	3.55e-36	128.0	COG1573@1|root,COG1573@2|Bacteria,1QJIF@1224|Proteobacteria,1THIQ@1236|Gammaproteobacteria,1XEAT@135618|Methylococcales	135618|Methylococcales	L	uracil-DNA	-	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_568482_2	1123368.AUIS01000011_gene1190	1.29e-73	229.0	COG0842@1|root,COG0842@2|Bacteria,1N55T@1224|Proteobacteria,1S29T@1236|Gammaproteobacteria,2NCSV@225057|Acidithiobacillales	225057|Acidithiobacillales	V	ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
k59_1742868_1	159450.NH14_11955	1.29e-42	157.0	COG2985@1|root,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,2VIHY@28216|Betaproteobacteria,1K26P@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Predicted Permease Membrane Region	-	-	-	ko:K07085	-	-	-	-	ko00000	2.A.81	-	-	Asp-Al_Ex,TrkA_C
k59_1034117_1	472759.Nhal_2242	1.71e-92	283.0	COG0055@1|root,COG0055@2|Bacteria,1N6UZ@1224|Proteobacteria,1RNQW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	-	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_796662_1	266834.SMc02721	5.31e-51	183.0	COG4772@1|root,COG4772@2|Bacteria,1MWDG@1224|Proteobacteria,2U4AH@28211|Alphaproteobacteria,4BGYW@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K16091	-	-	-	-	ko00000,ko02000	1.B.14.1.14	-	-	Plug,TonB_dep_Rec
k59_1214822_2	314278.NB231_12034	6.96e-65	200.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,1S3Q7@1236|Gammaproteobacteria,1WYAT@135613|Chromatiales	135613|Chromatiales	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
k59_862047_1	713586.KB900536_gene2049	1.71e-86	277.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1WWSJ@135613|Chromatiales	135613|Chromatiales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_1107250_1	448385.sce3316	1.21e-50	179.0	COG5297@1|root,COG5297@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase family 6	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase2,PSCyt3,PSD2,PSD3,PSD4,PSD5,Ricin_B_lectin
k59_1742881_1	37919.EP51_05900	3.83e-96	292.0	COG0604@1|root,COG0604@2|Bacteria,2GKFF@201174|Actinobacteria,4FZKF@85025|Nocardiaceae	201174|Actinobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.3.1.85,1.3.1.86	ko:K14446,ko:K17829	ko00630,ko00650,ko01120,ko01130,ko01200,map00630,map00650,map01120,map01130,map01200	M00373	R09291,R09738	RC00076,RC02481	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1450091_1	1504981.KO116_1904	4.75e-109	329.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1S01K@1236|Gammaproteobacteria,1XR9F@135619|Oceanospirillales	135619|Oceanospirillales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1034136_1	1234595.C725_2505	3.83e-13	73.9	COG3324@1|root,COG3324@2|Bacteria,1R81W@1224|Proteobacteria,2U6BE@28211|Alphaproteobacteria,4BS7Z@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
k59_1214836_1	398580.Dshi_0905	2.24e-11	66.6	COG2860@1|root,COG2860@2|Bacteria,1RHQN@1224|Proteobacteria,2U6B7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	UPF0126
k59_686678_1	550540.Fbal_2754	2.53e-08	50.8	COG2975@1|root,COG2975@2|Bacteria,1N7C1@1224|Proteobacteria,1SC9F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Fe-S assembly protein IscX	iscX	GO:0003674,GO:0004857,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0030234,GO:0031163,GO:0043086,GO:0043167,GO:0043169,GO:0044085,GO:0044092,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050790,GO:0051186,GO:0065007,GO:0065009,GO:0071840,GO:0098772	-	-	-	-	-	-	-	-	-	-	Fe-S_assembly
k59_686678_2	1121374.KB891586_gene2774	9e-58	187.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,1RNEJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.24,4.1.3.25,4.1.3.34	ko:K01644,ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01120,map01200,map02020	M00346,M00373,M00376	R00237,R00362,R00473,R00934	RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
k59_1107254_1	243233.MCA2174	3.44e-96	292.0	COG0803@1|root,COG0803@2|Bacteria,1RAQU@1224|Proteobacteria	1224|Proteobacteria	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
k59_1034143_1	340.xcc-b100_0908	1.14e-40	140.0	COG0251@1|root,COG0251@2|Bacteria,1RD3E@1224|Proteobacteria,1S6NI@1236|Gammaproteobacteria,1X6JQ@135614|Xanthomonadales	135614|Xanthomonadales	J	translation initiation inhibitor, yjgF family	tdcF	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_1151134_1	1122915.AUGY01000103_gene4744	6.48e-49	164.0	COG0637@1|root,COG0637@2|Bacteria,1V1N8@1239|Firmicutes,4HG58@91061|Bacilli,26VY3@186822|Paenibacillaceae	91061|Bacilli	S	Haloacid dehalogenase-like hydrolase	yhcW	GO:0003674,GO:0003824,GO:0003850,GO:0004346,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0044237,GO:0050308,GO:0050309	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_1214845_2	266117.Rxyl_0129	1.17e-06	50.1	COG0845@1|root,COG3260@1|root,COG3261@1|root,COG0845@2|Bacteria,COG3260@2|Bacteria,COG3261@2|Bacteria	2|Bacteria	C	NADH dehydrogenase	-	-	-	ko:K01991,ko:K02005,ko:K06147,ko:K16552	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18,1.B.18.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	AAA_11,AAA_12,Complex1_49kDa,HlyD_D23,Oxidored_q6
k59_1450105_1	935839.JAGJ01000018_gene2305	2.05e-94	283.0	COG0406@1|root,COG0406@2|Bacteria,2GMXF@201174|Actinobacteria,4F4DJ@85017|Promicromonosporaceae	201174|Actinobacteria	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_1151140_1	1121405.dsmv_2570	3.41e-63	201.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,42N9N@68525|delta/epsilon subdivisions,2WIY9@28221|Deltaproteobacteria,2MHVV@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ATP phosphoribosyltransferase	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
k59_1151140_2	1121405.dsmv_2571	1.94e-49	168.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WJ0U@28221|Deltaproteobacteria,2MI24@213118|Desulfobacterales	28221|Deltaproteobacteria	E	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_216672_1	983545.Glaag_0810	7.7e-41	139.0	COG0346@1|root,COG0346@2|Bacteria,1N1D4@1224|Proteobacteria,1S7IY@1236|Gammaproteobacteria,467V1@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_216672_2	272560.BPSL1406	7.84e-08	51.6	COG1544@1|root,COG1544@2|Bacteria,1RJ55@1224|Proteobacteria,2VR5Q@28216|Betaproteobacteria,1KAH3@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
k59_1742899_1	1218075.BAYA01000003_gene607	1.55e-38	143.0	28IQ7@1|root,2Z8PY@2|Bacteria,1NA66@1224|Proteobacteria,2VTQK@28216|Betaproteobacteria,1KDZW@119060|Burkholderiaceae	28216|Betaproteobacteria	S	RecT family	-	-	-	-	-	-	-	-	-	-	-	-	RecT
k59_745383_1	1249627.D779_3544	5.62e-44	154.0	COG2979@1|root,COG2979@2|Bacteria,1R95E@1224|Proteobacteria,1S2WZ@1236|Gammaproteobacteria,1WWAG@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF533)	-	-	-	-	-	-	-	-	-	-	-	-	DUF533
k59_451355_1	765913.ThidrDRAFT_1405	4.28e-63	218.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,LysM
k59_1214856_1	1449353.JQMQ01000005_gene1158	9.6e-65	209.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,2NF6S@228398|Streptacidiphilus	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_158472_1	1380354.JIAN01000006_gene467	1.38e-174	512.0	COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,4F10T@85016|Cellulomonadaceae	201174|Actinobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_216674_1	1150398.JIBJ01000008_gene668	1.79e-32	124.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,1W7WG@1268|Micrococcaceae	201174|Actinobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_216674_2	1172188.KB911827_gene4247	1.03e-30	120.0	COG3965@1|root,COG3965@2|Bacteria,2HXXU@201174|Actinobacteria,4FIDE@85021|Intrasporangiaceae	201174|Actinobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
k59_568538_1	765912.Thimo_3326	1.3e-105	331.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1WWXC@135613|Chromatiales	135613|Chromatiales	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1624045_1	1415779.JOMH01000001_gene3016	1.59e-74	251.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X5MD@135614|Xanthomonadales	135614|Xanthomonadales	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_334577_1	998674.ATTE01000001_gene3827	4.38e-62	209.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1151162_1	1168034.FH5T_14055	1.54e-68	210.0	COG0629@1|root,COG0629@2|Bacteria,4NQBK@976|Bacteroidetes,2FT5G@200643|Bacteroidia	976|Bacteroidetes	L	Single-stranded DNA-binding protein	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_1742919_1	631454.N177_2927	1.42e-73	240.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2TSTS@28211|Alphaproteobacteria,1JN0A@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	sfuB	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_1565873_1	1122622.ATWJ01000007_gene1774	1.76e-34	122.0	COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria,4FHRE@85021|Intrasporangiaceae	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	arsR	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
k59_796714_1	1121438.JNJA01000012_gene1566	1e-14	73.2	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,42MS9@68525|delta/epsilon subdivisions,2WJMS@28221|Deltaproteobacteria,2M8A2@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_796714_2	765910.MARPU_02635	1.07e-84	257.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1WWZU@135613|Chromatiales	135613|Chromatiales	M	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
k59_451381_1	1184607.AUCHE_05_04270	9.24e-75	250.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1149@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1149@2|Bacteria,2I995@201174|Actinobacteria	201174|Actinobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_216703_1	314278.NB231_05596	4.5e-18	82.8	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1WWB9@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_216703_2	396588.Tgr7_0768	1.19e-27	111.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,1WWCK@135613|Chromatiales	135613|Chromatiales	M	Peptidoglycan polymerase that is essential for cell division	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_568575_1	177437.HRM2_00650	1.19e-84	262.0	COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,42NWV@68525|delta/epsilon subdivisions,2WJWC@28221|Deltaproteobacteria,2MMJE@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Nitrate reductase, beta subunit	narH	-	1.7.5.1	ko:K00371,ko:K17051	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8	-	iAF987.Gmet_1021	Fer4_11,Nitr_red_bet_C
k59_568575_2	177437.HRM2_00660	6.2e-39	143.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,42P6X@68525|delta/epsilon subdivisions,2WK8U@28221|Deltaproteobacteria,2MN0V@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
k59_216704_1	768671.ThimaDRAFT_2365	1.25e-16	81.3	29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,1SBT1@1236|Gammaproteobacteria,1WYAZ@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4390)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4390
k59_1742938_1	1209984.BN978_04815	2.68e-23	103.0	COG3299@1|root,COG3299@2|Bacteria	2|Bacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
k59_1798311_1	930166.CD58_25120	2.39e-55	189.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_1107317_1	1449351.RISW2_05875	1.9e-29	117.0	COG2111@1|root,COG2111@2|Bacteria,1QVK4@1224|Proteobacteria,2TWGZ@28211|Alphaproteobacteria,4KNHX@93682|Roseivivax	28211|Alphaproteobacteria	P	Domain related to MnhB subunit of Na+/H+ antiporter	-	-	-	-	-	-	-	-	-	-	-	-	DUF4040,MnhB
k59_1128101_1	926569.ANT_21170	8.96e-07	55.5	COG4974@1|root,COG4974@2|Bacteria,2G8U5@200795|Chloroflexi	200795|Chloroflexi	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_373422_1	247490.KSU1_D0961	1.18e-30	125.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,2IZWU@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
k59_901690_1	246196.MSMEI_4587	9.97e-65	216.0	COG0204@1|root,COG0560@1|root,COG0204@2|Bacteria,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,233PB@1762|Mycobacteriaceae	201174|Actinobacteria	EI	HAD-superfamily subfamily IB hydrolase, TIGR01490	plsC	-	2.3.1.51,3.1.3.3	ko:K00655,ko:K15781	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase,HAD
k59_1251600_1	411462.DORLON_02412	3.78e-40	145.0	COG0130@1|root,COG0130@2|Bacteria,1TP9Y@1239|Firmicutes,24B46@186801|Clostridia,27V5K@189330|Dorea	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
k59_1716651_1	497964.CfE428DRAFT_3886	2.47e-44	156.0	COG4124@1|root,COG4124@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 26 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_26
k59_79886_1	446469.Sked_07440	2.44e-108	338.0	COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria	201174|Actinobacteria	C	NADH-quinone oxidoreductase	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_79886_2	754252.PFREUD_05210	1.64e-08	54.7	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,4DPP6@85009|Propionibacteriales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_257580_2	195105.CN97_13940	6.19e-39	138.0	COG3932@1|root,COG3932@2|Bacteria,1REE4@1224|Proteobacteria,2U7Z2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ABC-type transport system, permease components	exoD	-	-	-	-	-	-	-	-	-	-	-	ExoD
k59_719554_1	1095767.CAHD01000009_gene2145	5.52e-129	384.0	COG1217@1|root,COG1217@2|Bacteria,2GJUJ@201174|Actinobacteria,4F0JZ@85016|Cellulomonadaceae	201174|Actinobacteria	T	elongation factor Tu domain 2 protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_23910_2	1424334.W822_02240	7.66e-20	93.6	COG3713@1|root,COG3713@2|Bacteria,1NA1X@1224|Proteobacteria,2VVPV@28216|Betaproteobacteria,3T4YJ@506|Alcaligenaceae	28216|Betaproteobacteria	M	(Scaffolding) protein	mipA	-	-	ko:K07274	-	-	-	-	ko00000,ko02000	9.B.99.1	-	-	MipA
k59_836659_1	471853.Bcav_2351	1.06e-145	432.0	COG0728@1|root,COG0728@2|Bacteria,2GKWW@201174|Actinobacteria	201174|Actinobacteria	M	virulence factor MVIN family protein	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_775481_1	1403819.BATR01000191_gene6561	2.62e-21	89.7	COG0244@1|root,COG0244@2|Bacteria,46T4Q@74201|Verrucomicrobia,2IUF1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_775481_2	765869.BDW_11010	9.6e-10	56.2	COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,42SHZ@68525|delta/epsilon subdivisions,2MT33@213481|Bdellovibrionales,2WPFZ@28221|Deltaproteobacteria	213481|Bdellovibrionales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
k59_901707_1	1123360.thalar_02888	2.77e-71	231.0	COG1145@1|root,COG1290@1|root,COG1908@1|root,COG1145@2|Bacteria,COG1290@2|Bacteria,COG1908@2|Bacteria,1QSPU@1224|Proteobacteria,2UQID@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_B,FlpD
k59_132666_1	402626.Rpic_3691	3.29e-11	60.5	COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2VUFB@28216|Betaproteobacteria,1K8M3@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
k59_1540739_1	519989.ECTPHS_00909	9.08e-82	256.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1WWCI@135613|Chromatiales	135613|Chromatiales	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_1128115_1	1415779.JOMH01000001_gene2073	2.15e-60	206.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1X2ZN@135614|Xanthomonadales	135614|Xanthomonadales	S	Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
k59_425501_1	1121405.dsmv_2651	1.37e-177	511.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales	68525|delta/epsilon subdivisions	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1364789_1	519989.ECTPHS_02856	5.14e-92	287.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1WXRW@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_257618_1	323850.Shew_2175	3.88e-73	237.0	COG3067@1|root,COG3067@2|Bacteria,1MV0F@1224|Proteobacteria,1RPE3@1236|Gammaproteobacteria,2Q968@267890|Shewanellaceae	1236|Gammaproteobacteria	P	) H( ) antiporter that extrudes sodium in exchange for external protons	nhaB	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0010035,GO:0010038,GO:0010226,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042221,GO:0042592,GO:0044464,GO:0045851,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516,GO:1902600	-	ko:K03314	-	-	-	-	ko00000,ko02000	2.A.34.1	-	iECP_1309.ECP_1229,iLF82_1304.LF82_1485,iNRG857_1313.NRG857_06055,iUTI89_1310.UTI89_C1372	NhaB
k59_484306_1	395963.Bind_3497	9.5e-31	119.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,2TR14@28211|Alphaproteobacteria,3NABY@45404|Beijerinckiaceae	28211|Alphaproteobacteria	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_1189411_1	631362.Thi970DRAFT_01110	1.43e-50	178.0	COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,1RXY8@1236|Gammaproteobacteria,1WW0M@135613|Chromatiales	135613|Chromatiales	M	PFAM lipopolysaccharide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Wzz
k59_1841112_1	631362.Thi970DRAFT_04432	8e-176	502.0	COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,1T2D1@1236|Gammaproteobacteria,1X28U@135613|Chromatiales	135613|Chromatiales	P	Sodium/hydrogen exchanger family	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger
k59_1486647_1	1248232.BANQ01000032_gene3828	1.23e-41	141.0	COG3152@1|root,COG3152@2|Bacteria,1MZJ4@1224|Proteobacteria,1SA1N@1236|Gammaproteobacteria,1XY7E@135623|Vibrionales	135623|Vibrionales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF805
k59_1486647_2	323848.Nmul_A2699	1.1e-09	57.0	COG0221@1|root,COG0221@2|Bacteria,1RGCP@1224|Proteobacteria,2VRVG@28216|Betaproteobacteria,3747J@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Inorganic pyrophosphatase	-	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
k59_308148_1	105559.Nwat_3123	1.56e-81	264.0	COG0438@1|root,COG0438@2|Bacteria,1QZ01@1224|Proteobacteria,1RZJA@1236|Gammaproteobacteria,1X05E@135613|Chromatiales	135613|Chromatiales	M	sucrose synthase	-	-	2.4.1.13	ko:K00695	ko00500,ko01100,map00500,map01100	-	R00806	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glycos_transf_1,Sucrose_synth
k59_484307_1	65093.PCC7418_2893	1.11e-94	300.0	COG3119@1|root,COG3119@2|Bacteria,1G3QV@1117|Cyanobacteria	1117|Cyanobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1841113_1	546271.Selsp_1910	2.3e-11	65.1	COG0589@1|root,COG0589@2|Bacteria,1U42B@1239|Firmicutes,4H7IH@909932|Negativicutes	909932|Negativicutes	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_543095_1	1343739.PAP_05185	3.62e-40	148.0	COG2379@1|root,arCOG04170@2157|Archaea,2XSTZ@28890|Euryarchaeota,242J9@183968|Thermococci	183968|Thermococci	G	Glycerate kinase	-	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016491,GO:0016661,GO:0016662,GO:0016740,GO:0016772,GO:0043798,GO:0044237,GO:0055114	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
k59_960717_1	933262.AXAM01000023_gene655	6.63e-27	105.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,42S4I@68525|delta/epsilon subdivisions,2WNXV@28221|Deltaproteobacteria,2MNF8@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	fabG3	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_960717_2	1122137.AQXF01000003_gene2366	5.53e-88	275.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	electron transfer flavoprotein-ubiquinone oxidoreductase	etf	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8
k59_132693_1	367299.JOEE01000004_gene1373	2.52e-118	344.0	COG0564@1|root,COG0564@2|Bacteria,2GIY1@201174|Actinobacteria,4FFFW@85021|Intrasporangiaceae	201174|Actinobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_1251654_1	631362.Thi970DRAFT_00705	3.37e-88	272.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1WXC2@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1424413_2	722419.PH505_ah00160	1.45e-45	157.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,2Q1F5@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009898,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0019843,GO:0019897,GO:0019898,GO:0022613,GO:0031234,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0036211,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044877,GO:0046777,GO:0070181,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1901564	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
k59_484317_1	1144343.PMI41_00719	1.18e-31	117.0	COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,2UBS3@28211|Alphaproteobacteria,43KFX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)	hslR	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
k59_1424415_1	159450.NH14_21035	9.18e-21	95.5	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,1K1HX@119060|Burkholderiaceae	28216|Betaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1189418_1	472759.Nhal_3349	2.53e-12	72.4	COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_1189418_2	1122243.KB903778_gene952	1.53e-87	283.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,3NIKD@468|Moraxellaceae	1236|Gammaproteobacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	pilJ	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	MCPsignal,PilJ
k59_1010470_2	1207075.PputUW4_01557	4.02e-71	226.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,1RQVT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_132702_1	1150600.ADIARSV_2801	1.24e-40	151.0	COG3385@1|root,COG3385@2|Bacteria,4NKTU@976|Bacteroidetes	976|Bacteroidetes	L	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k59_1599106_1	1123400.KB904769_gene2787	1.07e-127	387.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,1RMVE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	torA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009033,GO:0009055,GO:0009060,GO:0009061,GO:0009322,GO:0009390,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016657,GO:0016661,GO:0016662,GO:0016667,GO:0016671,GO:0022900,GO:0030151,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0031975,GO:0032991,GO:0033744,GO:0033797,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0050626,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494	1.7.2.3,1.8.5.3,1.97.1.9	ko:K07306,ko:K07309,ko:K07310,ko:K07811,ko:K07812,ko:K08351	ko00450,ko00780,ko00920,ko01100,ko02020,map00450,map00780,map00920,map01100,map02020	-	R07229,R09501,R10127	RC02420,RC02555,RC03056	ko00000,ko00001,ko01000,ko02000	5.A.3.3,5.A.3.4	-	iE2348C_1286.E2348C_1672,iEC042_1314.EC042_1073,iECOK1_1307.ECOK1_3996,iECSE_1348.ECSE_0952,iEcHS_1320.EcHS_A3752,iEcolC_1368.EcolC_0165,iNRG857_1313.NRG857_07945,iNRG857_1313.NRG857_09385,iSFV_1184.SFV_1557,iUTI89_1310.UTI89_C4091,iZ_1308.Z1240	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1364820_1	985665.HPL003_14745	7.29e-68	226.0	COG0021@1|root,COG0021@2|Bacteria,1TPIB@1239|Firmicutes,4HADA@91061|Bacilli,26RNW@186822|Paenibacillaceae	91061|Bacilli	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_836715_1	765420.OSCT_1579	6.78e-06	53.1	COG0823@1|root,COG0823@2|Bacteria,2G78A@200795|Chloroflexi,375FV@32061|Chloroflexia	32061|Chloroflexia	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_308173_1	316067.Geob_3517	1.87e-63	206.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,43T7M@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_308173_2	443143.GM18_1809	6.59e-90	269.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42P96@68525|delta/epsilon subdivisions,2WJE9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1775155_1	2340.JV46_06100	3.89e-125	365.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RP6X@1236|Gammaproteobacteria,1J5GC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Peptidase family U32	yhbU	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
k59_1128159_1	686340.Metal_2566	2.71e-69	230.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1XG1W@135618|Methylococcales	135618|Methylococcales	V	ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
k59_1077404_1	1206737.BAGF01000032_gene1880	1.85e-79	250.0	COG0141@1|root,COG0141@2|Bacteria,2GKKA@201174|Actinobacteria,4FWA1@85025|Nocardiaceae	201174|Actinobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1599	Histidinol_dh
k59_1077404_2	1304865.JAGF01000001_gene3692	3.89e-30	119.0	COG0514@1|root,COG1040@1|root,COG0514@2|Bacteria,COG1040@2|Bacteria,2GJSS@201174|Actinobacteria,4F13I@85016|Cellulomonadaceae	201174|Actinobacteria	L	helicase superfamily c-terminal domain	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
k59_719616_1	313628.LNTAR_05306	1.03e-69	222.0	COG1600@1|root,COG1600@2|Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16,HEAT_2
k59_1716724_1	1123255.JHYS01000013_gene15	2.9e-26	104.0	COG4319@1|root,COG4319@2|Bacteria,1QXYE@1224|Proteobacteria,2WHS9@28216|Betaproteobacteria,4AI06@80864|Comamonadaceae	28216|Betaproteobacteria	S	Nuclear transport factor 2 (NTF2) domain	-	-	5.3.3.1	ko:K01822	ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120	M00107,M00110	R01837,R02216,R02499,R02840,R03327,R04163,R04678,R04849,R09955	RC00146,RC00762	ko00000,ko00001,ko00002,ko01000	-	-	-	SnoaL_2
k59_601381_1	384765.SIAM614_16532	1.58e-49	163.0	COG1853@1|root,COG1853@2|Bacteria,1MUPP@1224|Proteobacteria,2TT7S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
k59_257661_1	232346.JHQL01000004_gene1732	1.5e-32	127.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,1XICE@135619|Oceanospirillales	135619|Oceanospirillales	M	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
k59_257661_2	870187.Thini_0145	3.43e-47	173.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,45ZMV@72273|Thiotrichales	72273|Thiotrichales	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_2,OstA_C
k59_1424440_1	6669.EFX62991	9.03e-19	78.2	2CZUP@1|root,2SBR2@2759|Eukaryota,396NA@33154|Opisthokonta,3CB0N@33208|Metazoa,3DS94@33213|Bilateria,423X4@6656|Arthropoda	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_836732_1	367299.JOEE01000001_gene1825	6.5e-80	248.0	COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria,4FF89@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the aspartate-semialdehyde dehydrogenase family	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_601400_1	338963.Pcar_3052	1.21e-85	271.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42N7X@68525|delta/epsilon subdivisions,2WMM9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1128178_1	593750.Metfor_1904	3e-40	150.0	COG1196@1|root,arCOG00371@2157|Archaea	2157|Archaea	D	Required for chromosome condensation and partitioning	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12
k59_1251708_1	519989.ECTPHS_09138	3.09e-06	55.1	COG0651@1|root,COG0651@2|Bacteria,1N6BY@1224|Proteobacteria,1RR4C@1236|Gammaproteobacteria,1WWFY@135613|Chromatiales	135613|Chromatiales	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
k59_1010498_1	243159.AFE_2907	1.39e-120	380.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,2NBVM@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Bacterial transglutaminase-like N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
k59_775555_1	1463879.JOHP01000015_gene4530	2.29e-90	274.0	COG0745@1|root,COG0745@2|Bacteria,2GK5S@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	resD	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_308211_1	1123073.KB899241_gene3250	3.6e-29	112.0	COG3239@1|root,COG3239@2|Bacteria,1MY4I@1224|Proteobacteria,1S0IS@1236|Gammaproteobacteria,1X4IQ@135614|Xanthomonadales	135614|Xanthomonadales	I	Fatty acid desaturase	-	-	1.14.19.23,1.14.19.45	ko:K10255	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
k59_543156_1	367299.JOEE01000007_gene83	0.000519	45.4	COG1983@1|root,COG1983@2|Bacteria,2GIVS@201174|Actinobacteria,4FH64@85021|Intrasporangiaceae	201174|Actinobacteria	KT	PspC domain	pspC	-	-	-	-	-	-	-	-	-	-	-	DUF2154,PspC
k59_257692_1	1123504.JQKD01000007_gene3399	0.000604	46.2	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2VSW6@28216|Betaproteobacteria,4AEJJ@80864|Comamonadaceae	28216|Betaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1540822_1	1121405.dsmv_0971	9.66e-94	288.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2MHS6@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_960819_2	582899.Hden_0691	9.25e-129	374.0	COG1148@1|root,COG1148@2|Bacteria,1R882@1224|Proteobacteria,2U526@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD dependent oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Pyr_redox_2
k59_425584_1	1347393.HG726029_gene2047	4.47e-11	67.0	COG0793@1|root,COG0793@2|Bacteria,4NFKJ@976|Bacteroidetes,2FNZE@200643|Bacteroidia,4AKXH@815|Bacteroidaceae	976|Bacteroidetes	M	peptidase S41	-	-	-	-	-	-	-	-	-	-	-	-	PDZ,PDZ_2,Peptidase_S41
k59_425584_2	715451.ambt_10705	3.05e-09	58.2	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RMJU@1236|Gammaproteobacteria,466CG@72275|Alteromonadaceae	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	ycdF	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
k59_1841225_1	1116472.MGMO_73c00090	1.56e-167	479.0	COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,1RQHX@1236|Gammaproteobacteria,1XEVC@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4478)	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DUF3412,DUF4478,Lysine_decarbox
k59_543168_1	398511.BpOF4_10705	1.37e-34	135.0	COG2366@1|root,COG2366@2|Bacteria,1UFHA@1239|Firmicutes,4HACM@91061|Bacilli,1ZCMT@1386|Bacillus	91061|Bacilli	S	Penicillin amidase	acyII	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
k59_775567_1	765913.ThidrDRAFT_3143	1.14e-23	98.2	COG3009@1|root,COG3009@2|Bacteria,1N8BW@1224|Proteobacteria,1S576@1236|Gammaproteobacteria,1WYCB@135613|Chromatiales	135613|Chromatiales	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K09857	-	-	-	-	ko00000	-	-	-	ABC_trans_aux
k59_1314212_2	1394178.AWOO02000059_gene572	8.37e-62	192.0	COG2764@1|root,COG2764@2|Bacteria,2IKY5@201174|Actinobacteria,4EJ2E@85012|Streptosporangiales	201174|Actinobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt,Glyoxalase
k59_426405_1	1385518.N798_01040	2.61e-67	211.0	COG2141@1|root,COG2141@2|Bacteria,2GJI7@201174|Actinobacteria,4FE9E@85021|Intrasporangiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
k59_426405_2	313589.JNB_15788	1.73e-45	150.0	COG3255@1|root,COG3255@2|Bacteria,2IQBF@201174|Actinobacteria,4FH9C@85021|Intrasporangiaceae	201174|Actinobacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
k59_1541688_1	555778.Hneap_0739	6.43e-12	65.1	COG2143@1|root,COG2143@2|Bacteria,1RB3S@1224|Proteobacteria,1S2A7@1236|Gammaproteobacteria,1WXYQ@135613|Chromatiales	135613|Chromatiales	O	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
k59_1660179_1	377629.TERTU_1969	2.58e-80	265.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,2PMX1@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	D	FtsK/SpoIIIE family	ftsK	GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1011133_1	1283300.ATXB01000001_gene1568	2.05e-16	77.8	COG0224@1|root,COG0224@2|Bacteria,1RIE5@1224|Proteobacteria,1S3ZW@1236|Gammaproteobacteria,1XF9U@135618|Methylococcales	135618|Methylococcales	C	ATP synthase	-	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_1011133_2	1283300.ATXB01000001_gene1567	1.17e-28	115.0	COG0056@1|root,COG0056@2|Bacteria,1MVHM@1224|Proteobacteria,1RMVT@1236|Gammaproteobacteria,1XDQW@135618|Methylococcales	135618|Methylococcales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	-	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_374812_1	367299.JOEE01000004_gene1143	5.19e-95	298.0	COG1200@1|root,COG1200@2|Bacteria,2GKA3@201174|Actinobacteria,4FE3F@85021|Intrasporangiaceae	201174|Actinobacteria	L	ATP-dependent DNA helicase RecG	recG	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge,tRNA_anti-codon
k59_776207_2	765912.Thimo_2538	1.31e-61	202.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1WXB7@135613|Chromatiales	135613|Chromatiales	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_309105_1	90814.KL370892_gene2147	2.35e-43	152.0	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,460ST@72273|Thiotrichales	72273|Thiotrichales	C	PFAM cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_1547681_1	870187.Thini_4246	1.66e-64	216.0	COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07673	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3
k59_432586_2	446465.Bfae_10170	1.44e-31	127.0	COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria,4FCAF@85020|Dermabacteraceae	201174|Actinobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
k59_383857_1	1267005.KB911257_gene1080	2.34e-128	369.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria,3N6CS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Two component transcriptional regulator PhoB, winged helix family	phoB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_726404_1	1168059.KB899087_gene1752	1e-21	86.7	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,3F1RQ@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	'Cold-shock' DNA-binding domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_1260941_1	1266909.AUAG01000003_gene890	1.18e-12	67.4	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,1WX40@135613|Chromatiales	135613|Chromatiales	EH	PFAM Aminotransferase, class IV	-	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
k59_1260941_2	697282.Mettu_1399	4.57e-26	98.6	COG2921@1|root,COG2921@2|Bacteria,1PJDX@1224|Proteobacteria,1THTC@1236|Gammaproteobacteria,1XFN8@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0250 family	-	-	-	ko:K09158	-	-	-	-	ko00000	-	-	-	DUF493
k59_1260941_3	1123053.AUDG01000003_gene2665	1.64e-39	138.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1WX46@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_608660_1	935839.JAGJ01000002_gene760	3.7e-293	813.0	COG0018@1|root,COG0018@2|Bacteria,2GKQ3@201174|Actinobacteria,4F378@85017|Promicromonosporaceae	201174|Actinobacteria	J	Arginyl tRNA synthetase N terminal dom	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_843907_1	1049564.TevJSym_cb00050	2.77e-73	242.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1J6D9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin,Thioredoxin_7
k59_971221_1	768671.ThimaDRAFT_2784	2.05e-43	160.0	COG0834@1|root,COG1301@1|root,COG0834@2|Bacteria,COG1301@2|Bacteria,1P22C@1224|Proteobacteria,1RSGY@1236|Gammaproteobacteria,1WZZV@135613|Chromatiales	135613|Chromatiales	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3,SDF
k59_1851669_1	1454202.PPBDW_131015___1	8.71e-53	180.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1XTSW@135623|Vibrionales	135623|Vibrionales	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
k59_1495397_1	1298880.AUEV01000012_gene5069	1.12e-69	224.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria	201174|Actinobacteria	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_971231_2	998088.B565_1502	2.24e-26	105.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1Y3VU@135624|Aeromonadales	135624|Aeromonadales	S	AI-2E family transporter	-	-	-	ko:K03548	-	-	-	-	ko00000,ko02000	2.A.86.1	-	-	AI-2E_transport
k59_608668_1	1049564.TevJSym_an00390	5.25e-94	285.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,1RMUQ@1236|Gammaproteobacteria,1J4P4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iSbBS512_1146.SbBS512_E3351	PGK
k59_1666610_1	243231.GSU2433	6.84e-52	186.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,43THJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
k59_198307_1	590998.Celf_2509	8.35e-68	228.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	wgeG	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Radical_SAM,SPASM
k59_1495407_1	1255043.TVNIR_1086	3.37e-56	179.0	COG1416@1|root,COG1416@2|Bacteria,1NP3E@1224|Proteobacteria,1SF5I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DsrE/DsrF-like family	-	-	-	ko:K09004	-	-	-	-	ko00000	-	-	-	DrsE
k59_1495407_2	1123514.KB905899_gene1933	1.26e-38	139.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RR4I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1323422_1	207954.MED92_04649	3.98e-57	192.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1XHQ8@135619|Oceanospirillales	135619|Oceanospirillales	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	ubiH	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_1431754_1	1262915.BN574_00035	1.11e-22	102.0	COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,4H314@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_269259_1	754476.Q7A_1146	8.67e-82	265.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,45ZQX@72273|Thiotrichales	72273|Thiotrichales	V	ABC transporter transmembrane region	-	-	-	ko:K12541	ko02010,map02010	M00330	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.3,3.A.1.109.4	-	-	ABC_membrane,ABC_tran,Peptidase_C39
k59_1323437_1	765911.Thivi_0931	2.55e-79	249.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1WXMI@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3,HlyD_D23
k59_668703_1	479433.Caci_8707	3.64e-58	182.0	COG3304@1|root,COG3304@2|Bacteria,2IKS5@201174|Actinobacteria	201174|Actinobacteria	S	membrane	yccF	-	-	-	-	-	-	-	-	-	-	-	YccF
k59_668703_2	649743.HMPREF0972_02416	2.28e-51	176.0	COG0325@1|root,COG0325@2|Bacteria,2GMRJ@201174|Actinobacteria,4D339@85005|Actinomycetales	201174|Actinobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
k59_668703_3	1045009.AFXQ01000001_gene2266	0.000141	43.9	COG0095@1|root,COG0095@2|Bacteria,2GJV5@201174|Actinobacteria,1W7UM@1268|Micrococcaceae	201174|Actinobacteria	H	PFAM Biotin lipoate A B protein ligase	lplA	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_270243_1	2340.JV46_19800	8.04e-42	146.0	COG1796@1|root,COG1796@2|Bacteria,1QF8Z@1224|Proteobacteria,1RRQ5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Helix-hairpin-helix domain	-	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	HHH_5,HHH_8
k59_270243_2	62928.azo1701	9.4e-08	53.1	COG3235@1|root,COG3235@2|Bacteria,1RDHR@1224|Proteobacteria,2VRKF@28216|Betaproteobacteria,2KWF3@206389|Rhodocyclales	206389|Rhodocyclales	S	Cobalt uptake substrate-specific transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CbiM
k59_140475_1	1054217.TALC_01391	2.05e-46	163.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,242ID@183967|Thermoplasmata	2157|Archaea	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_727195_1	933262.AXAM01000029_gene2752	8.54e-73	234.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MAV@68525|delta/epsilon subdivisions,2WJC9@28221|Deltaproteobacteria,2MIPJ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	cimA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_36746_1	876044.IMCC3088_635	4.42e-136	396.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1MWNX@1224|Proteobacteria,1RQHG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,LZ_Tnp_IS481,rve
k59_36746_2	504472.Slin_2663	4.31e-38	132.0	COG2963@1|root,COG2963@2|Bacteria,4NQ94@976|Bacteroidetes,47T18@768503|Cytophagia	976|Bacteroidetes	L	PFAM transposase IS3 IS911 family protein	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_91896_1	326297.Sama_2190	2.53e-69	220.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,2Q92K@267890|Shewanellaceae	1236|Gammaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_36753_1	1367847.JCM7686_0518	5.01e-28	110.0	COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,2TR0C@28211|Alphaproteobacteria,2PWGS@265|Paracoccus	28211|Alphaproteobacteria	CO	Thioredoxin-like	tlpA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
k59_1548434_2	1267005.KB911262_gene3344	1.03e-29	108.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2UBRZ@28211|Alphaproteobacteria,3N735@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
k59_1548434_3	713586.KB900536_gene3062	7.77e-06	48.9	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1WVXW@135613|Chromatiales	135613|Chromatiales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
k59_1496278_1	883078.HMPREF9695_01135	1.54e-94	296.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2TRNG@28211|Alphaproteobacteria,3JRX0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Cytochrome c-type biogenesis protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_1432552_1	1121406.JAEX01000036_gene723	6.67e-08	50.8	2BWYG@1|root,2ZC7F@2|Bacteria,1RCI1@1224|Proteobacteria,42R7Y@68525|delta/epsilon subdivisions,2WMTM@28221|Deltaproteobacteria,2MB8Q@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1432552_2	1307759.JOMJ01000003_gene975	3.52e-91	274.0	COG4974@1|root,COG4974@2|Bacteria,1R440@1224|Proteobacteria,43AEK@68525|delta/epsilon subdivisions,2WM8V@28221|Deltaproteobacteria,2M9UU@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_140487_1	652103.Rpdx1_3939	4.11e-06	52.0	COG0633@1|root,COG2114@1|root,COG0633@2|Bacteria,COG2114@2|Bacteria,1N5XC@1224|Proteobacteria,2TRGX@28211|Alphaproteobacteria,3JQU2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CT	Adenylyl- / guanylyl cyclase, catalytic domain	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Guanylate_cyc
k59_140487_2	177437.HRM2_24640	0.0002	42.7	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,42SD7@68525|delta/epsilon subdivisions,2WPI5@28221|Deltaproteobacteria,2MIP3@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_270270_1	1449044.JMLE01000010_gene3651	1.37e-49	166.0	COG3064@1|root,COG3064@2|Bacteria,2IPMP@201174|Actinobacteria	201174|Actinobacteria	M	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_913683_1	479432.Sros_1804	2.01e-48	171.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4EIH8@85012|Streptosporangiales	201174|Actinobacteria	E	TOBE domain	-	-	3.6.3.31	ko:K11072,ko:K11076	ko02010,map02010	M00299,M00300	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1,3.A.1.11.2	-	-	ABC_tran,TOBE_2
k59_199062_1	65393.PCC7424_3569	8.52e-119	353.0	COG1032@1|root,COG1032@2|Bacteria,1G3ZK@1117|Cyanobacteria,3KG2X@43988|Cyanothece	1117|Cyanobacteria	C	TIGRFAM hopanoid biosynthesis associated radical SAM protein HpnJ	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
k59_1548440_1	1283300.ATXB01000001_gene1437	2.06e-40	140.0	COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,1RP5A@1236|Gammaproteobacteria,1XF6C@135618|Methylococcales	135618|Methylococcales	P	Inositol monophosphatase family	-	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
k59_492224_1	1414720.CBYM010000034_gene1888	3.09e-50	177.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,36E6C@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_727211_1	1255043.TVNIR_2527	1.43e-141	424.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WWIV@135613|Chromatiales	135613|Chromatiales	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_316435_1	314230.DSM3645_11037	3.16e-64	220.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2IXY9@203682|Planctomycetes	203682|Planctomycetes	C	Acyl-CoA synthetase (NDP forming)	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1782947_1	572477.Alvin_0544	4.05e-118	367.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,1RPDC@1236|Gammaproteobacteria,1WWR8@135613|Chromatiales	135613|Chromatiales	S	PFAM Bacterial domain of	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
k59_1017227_1	1249627.D779_3891	2.2e-100	307.0	COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,1RNCV@1236|Gammaproteobacteria,1WW63@135613|Chromatiales	135613|Chromatiales	J	tRNA modifying enzyme	-	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
k59_1667433_1	95619.PM1_0225705	4.09e-23	89.4	COG0333@1|root,COG0333@2|Bacteria,1N6RF@1224|Proteobacteria,1SC9G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
k59_1667433_2	1177179.A11A3_04495	7.17e-10	60.1	COG1399@1|root,COG1399@2|Bacteria,1PGKW@1224|Proteobacteria,1RRK3@1236|Gammaproteobacteria,1XJKJ@135619|Oceanospirillales	135619|Oceanospirillales	S	metal-binding, possibly nucleic acid-binding protein	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
k59_1432573_1	1229203.KI301992_gene1041	3.09e-52	186.0	COG0072@1|root,COG0072@2|Bacteria,2GMFD@201174|Actinobacteria,3UW7Y@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_972743_1	338969.Rfer_0831	4.09e-146	438.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2VJ54@28216|Betaproteobacteria,4ACBR@80864|Comamonadaceae	28216|Betaproteobacteria	O	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
k59_385429_1	1300345.LF41_2649	2.56e-44	166.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9I0@135614|Xanthomonadales	135614|Xanthomonadales	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_433447_1	258052.JNYV01000005_gene2320	1.4e-07	58.5	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,2M20W@2063|Kitasatospora	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
k59_1261848_1	316274.Haur_4920	5.07e-26	100.0	COG0091@1|root,COG0091@2|Bacteria,2G6ZQ@200795|Chloroflexi,375TE@32061|Chloroflexia	32061|Chloroflexia	J	its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_1724843_1	34506.g2522	5.66e-33	128.0	COG0149@1|root,KOG1643@2759|Eukaryota,3AF0M@33154|Opisthokonta,3BYE6@33208|Metazoa,3DFAF@33213|Bilateria,40QZ4@6231|Nematoda,1M0NK@119089|Chromadorea,4172J@6236|Rhabditida	2759|Eukaryota	G	Triosephosphate isomerase	-	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
k59_1724843_2	765911.Thivi_0845	2.89e-33	118.0	COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,1S6B0@1236|Gammaproteobacteria,1WYPJ@135613|Chromatiales	135613|Chromatiales	P	PFAM Rieske 2Fe-2S	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
k59_1372563_1	1255043.TVNIR_1943	4.75e-92	284.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1WW6G@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1853244_1	1380393.JHVP01000001_gene2050	7.58e-90	285.0	COG1226@1|root,COG1226@2|Bacteria	2|Bacteria	P	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)	kch	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_N
k59_972761_2	1151122.AQYD01000005_gene3510	7.14e-16	79.0	COG0745@1|root,COG1587@1|root,COG0745@2|Bacteria,COG1587@2|Bacteria,2GKMM@201174|Actinobacteria,4FM3K@85023|Microbacteriaceae	201174|Actinobacteria	HKT	Uroporphyrinogen-III synthase HemD	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,Trans_reg_C
k59_199087_1	631362.Thi970DRAFT_04466	9.72e-99	301.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1WW6N@135613|Chromatiales	135613|Chromatiales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_913741_1	1095769.CAHF01000007_gene1664	7.3e-83	251.0	COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,2VN5A@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase (SDR)	-	-	1.1.1.401	ko:K21883	ko00051,ko01120,map00051,map01120	-	R11339	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short,adh_short_C2
k59_385444_1	1123325.JHUV01000015_gene245	1.29e-41	156.0	COG0587@1|root,COG0587@2|Bacteria,2G3PZ@200783|Aquificae	200783|Aquificae	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon
k59_1197543_1	1123368.AUIS01000010_gene2370	3.4e-64	203.0	COG4798@1|root,COG4798@2|Bacteria,1QUNP@1224|Proteobacteria,1S3N0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_844728_1	1123065.ATWL01000001_gene250	2.47e-60	191.0	COG0703@1|root,COG0703@2|Bacteria,2GRFW@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
k59_270311_1	396588.Tgr7_3076	2.09e-70	221.0	COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,1RREE@1236|Gammaproteobacteria,1WWMU@135613|Chromatiales	135613|Chromatiales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_91990_1	1304885.AUEY01000022_gene3410	3.08e-55	187.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2MI3G@213118|Desulfobacterales	28221|Deltaproteobacteria	T	response regulator receiver	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_36819_1	686340.Metal_1067	2.07e-64	206.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,1RPRD@1236|Gammaproteobacteria,1XEDZ@135618|Methylococcales	135618|Methylococcales	C	alcohol dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
k59_550846_1	416870.llmg_1662	1.54e-06	51.2	COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,4HR56@91061|Bacilli,1YCG9@1357|Lactococcus	91061|Bacilli	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_550846_2	1173026.Glo7428_2556	0.000171	44.3	COG0745@1|root,COG2114@1|root,COG2197@1|root,COG2203@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2197@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,1G0F6@1117|Cyanobacteria	1117|Cyanobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	cyaC	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,Guanylate_cyc,HATPase_c,HisKA,Response_reg
k59_385458_1	1123065.ATWL01000007_gene3335	2.02e-14	72.4	COG2508@1|root,COG2508@2|Bacteria,2GN0S@201174|Actinobacteria	201174|Actinobacteria	QT	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
k59_385458_2	1298880.AUEV01000003_gene3360	1.06e-21	93.2	COG0331@1|root,COG0331@2|Bacteria,2GME0@201174|Actinobacteria	201174|Actinobacteria	I	PFAM Acyl transferase	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005835,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
k59_668766_1	666685.R2APBS1_0461	1.05e-57	201.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,1X53W@135614|Xanthomonadales	135614|Xanthomonadales	S	L,D-transpeptidase catalytic domain	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_1612380_2	1112216.JH594425_gene127	7.83e-73	232.0	COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,2TSP6@28211|Alphaproteobacteria,2K002@204457|Sphingomonadales	204457|Sphingomonadales	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
k59_1612380_3	1150474.JQJI01000004_gene441	1.08e-58	187.0	COG1898@1|root,COG1898@2|Bacteria,2GDVU@200918|Thermotogae	200918|Thermotogae	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
k59_924024_1	314278.NB231_11669	3.05e-33	124.0	COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,1WY9S@135613|Chromatiales	135613|Chromatiales	O	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host	djlA	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
k59_924024_2	380703.AHA_3185	1.3e-53	175.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,1Y3XD@135624|Aeromonadales	135624|Aeromonadales	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_983115_1	452637.Oter_2923	2.97e-09	57.0	COG1063@1|root,COG1063@2|Bacteria,46UMA@74201|Verrucomicrobia,3KA31@414999|Opitutae	74201|Verrucomicrobia	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_983115_2	1120963.KB894491_gene677	7.96e-17	83.6	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,2Q1PW@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	OU	signal peptide peptidase	sppA	GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016485,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_277998_1	519442.Huta_0754	7.09e-09	59.7	COG0589@1|root,arCOG02053@2157|Archaea,2XX8Y@28890|Euryarchaeota,23VQJ@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1140656_1	511062.GU3_02120	3.25e-88	277.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1Y3U5@135624|Aeromonadales	135624|Aeromonadales	NU	COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	exeE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_322311_1	1123368.AUIS01000006_gene588	7.17e-142	406.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,1RP7S@1236|Gammaproteobacteria,2NCP9@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Carbon-nitrogen hydrolase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
k59_1268397_1	1121434.AULY01000006_gene929	1.67e-52	186.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,43C4Y@68525|delta/epsilon subdivisions,2X7FA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_556716_1	323098.Nwi_2431	2.15e-58	194.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2TSBK@28211|Alphaproteobacteria,3JRC8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_146486_1	502025.Hoch_3218	2.22e-21	95.9	COG1451@1|root,COG1451@2|Bacteria,1P1X1@1224|Proteobacteria,4314C@68525|delta/epsilon subdivisions,2X3BB@28221|Deltaproteobacteria,2YV83@29|Myxococcales	28221|Deltaproteobacteria	S	nucleotide metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_102129_1	935565.JAEM01000006_gene3963	4.68e-20	87.8	COG2020@1|root,COG2020@2|Bacteria,1MZ7S@1224|Proteobacteria,2UBYC@28211|Alphaproteobacteria,2PX90@265|Paracoccus	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_674744_1	420324.KI912039_gene2174	1.43e-85	266.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria,1JTAK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_395604_1	1123400.KB904747_gene622	2.72e-23	99.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,4629A@72273|Thiotrichales	72273|Thiotrichales	P	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
k59_1554207_1	521393.JH806633_gene1430	1.7e-59	204.0	COG4987@1|root,COG4987@2|Bacteria,2H79B@201174|Actinobacteria,4D40H@85005|Actinomycetales	201174|Actinobacteria	CO	thiol reductant ABC exporter, CydC subunit	cydC	-	-	ko:K06148,ko:K16012	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.129	-	-	ABC_membrane,ABC_tran
k59_1730736_1	335543.Sfum_0543	2.75e-60	193.0	COG1014@1|root,COG1014@2|Bacteria,1N0EJ@1224|Proteobacteria,42UN6@68525|delta/epsilon subdivisions,2WQCE@28221|Deltaproteobacteria,2MRW1@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
k59_205061_1	1049564.TevJSym_ab01230	1.32e-53	179.0	COG2242@1|root,COG2242@2|Bacteria,1R79F@1224|Proteobacteria,1RY3Z@1236|Gammaproteobacteria,1J8AJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_1378308_1	522306.CAP2UW1_1518	3.92e-22	100.0	COG5380@1|root,COG5380@2|Bacteria,1N6UY@1224|Proteobacteria,2VRU4@28216|Betaproteobacteria	28216|Betaproteobacteria	O	lipid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_45044_1	545276.KB898726_gene943	2.7e-07	50.4	COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,1S90K@1236|Gammaproteobacteria,1WYEK@135613|Chromatiales	135613|Chromatiales	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_45044_2	472759.Nhal_0529	3.1e-53	174.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1WX5A@135613|Chromatiales	135613|Chromatiales	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k59_556729_1	748247.AZKH_1019	6.71e-45	155.0	COG5662@1|root,COG5662@2|Bacteria,1RK1X@1224|Proteobacteria,2VQDP@28216|Betaproteobacteria,2KW8V@206389|Rhodocyclales	206389|Rhodocyclales	K	transmembrane transcriptional regulator (Anti-sigma factor)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_45045_1	1415779.JOMH01000001_gene2667	3.5e-05	50.8	COG0489@1|root,COG0489@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria,1X5HE@135614|Xanthomonadales	135614|Xanthomonadales	D	protein involved in exopolysaccharide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
k59_1863658_1	335543.Sfum_4043	1.27e-17	80.5	COG2221@1|root,COG2221@2|Bacteria,1MVZQ@1224|Proteobacteria,42N7B@68525|delta/epsilon subdivisions,2WJYE@28221|Deltaproteobacteria,2MQX7@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM sulfite reductase, dissimilatory-type beta subunit	dsrB	-	1.8.99.5	ko:K11181	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7,NIR_SIR,NIR_SIR_ferr
k59_1863658_2	177437.HRM2_42370	5.07e-81	256.0	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,42M8T@68525|delta/epsilon subdivisions,2WIXE@28221|Deltaproteobacteria,2MHZW@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,CbiA,GATase_3
k59_1268416_1	177437.HRM2_32610	1.78e-80	248.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NF6@68525|delta/epsilon subdivisions,2WKVH@28221|Deltaproteobacteria,2MI4N@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_102165_1	1121035.AUCH01000012_gene2908	5.61e-73	241.0	COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,2VIV2@28216|Betaproteobacteria,2KVND@206389|Rhodocyclales	206389|Rhodocyclales	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_983170_1	1123065.ATWL01000001_gene213	2.4e-103	318.0	COG0441@1|root,COG0441@2|Bacteria,2GKTC@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
k59_322338_1	1231391.AMZF01000049_gene984	6.77e-75	236.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2VHRF@28216|Betaproteobacteria,3T1MH@506|Alcaligenaceae	28216|Betaproteobacteria	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_395640_1	1209072.ALBT01000028_gene1281	3.39e-152	439.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,1RMX0@1236|Gammaproteobacteria,1FGVH@10|Cellvibrio	1236|Gammaproteobacteria	M	UDP binding domain	wecC	-	-	ko:K02474	ko00520,map00520	-	R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_787261_1	335543.Sfum_4045	1.6e-63	194.0	COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,42SN5@68525|delta/epsilon subdivisions,2WP28@28221|Deltaproteobacteria,2MS1Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	DsrC like protein	dsrC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_787261_2	439235.Dalk_4298	7.13e-05	45.8	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,42M8T@68525|delta/epsilon subdivisions,2WIXE@28221|Deltaproteobacteria,2MHZW@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,CbiA,GATase_3
k59_1335358_1	349124.Hhal_1191	1.37e-55	176.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,1WYGS@135613|Chromatiales	135613|Chromatiales	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
k59_102172_1	1323361.JPOC01000008_gene3365	1.03e-70	234.0	COG2409@1|root,COG2409@2|Bacteria,2GIRQ@201174|Actinobacteria,4FW6E@85025|Nocardiaceae	201174|Actinobacteria	T	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
k59_1094166_2	1454010.JEOE01000002_gene394	9.15e-59	187.0	29850@1|root,2ZVAX@2|Bacteria,2GKR1@201174|Actinobacteria,4F1AA@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_439453_1	933262.AXAM01000102_gene1243	5.04e-71	233.0	COG1032@1|root,COG1032@2|Bacteria,1MU15@1224|Proteobacteria,42N12@68525|delta/epsilon subdivisions,2WK0X@28221|Deltaproteobacteria,2MI8S@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_439453_2	933262.AXAM01000013_gene1293	6.06e-10	59.3	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2WJAZ@28221|Deltaproteobacteria,2MHTR@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_787265_1	1232410.KI421416_gene2620	1.63e-68	216.0	COG0842@1|root,COG0842@2|Bacteria,1N55T@1224|Proteobacteria,42N8F@68525|delta/epsilon subdivisions,2WK3B@28221|Deltaproteobacteria,43U4Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
k59_205092_1	1120965.AUBV01000004_gene716	1.43e-35	122.0	COG4327@1|root,COG4327@2|Bacteria,4NSV7@976|Bacteroidetes	976|Bacteroidetes	S	solute sodium symporter, small subunit	-	-	-	-	-	-	-	-	-	-	-	-	DUF4212
k59_205092_2	156889.Mmc1_1042	3.47e-42	152.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2TTA4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_983196_1	1122134.KB893651_gene1782	2.23e-38	130.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,1S5XT@1236|Gammaproteobacteria,1XK4T@135619|Oceanospirillales	135619|Oceanospirillales	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_983196_2	930166.CD58_26650	2.46e-49	157.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,1S5VT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_983196_3	519989.ECTPHS_13073	1.93e-151	431.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,1RMGR@1236|Gammaproteobacteria,1WWAW@135613|Chromatiales	135613|Chromatiales	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_983196_4	1177154.Y5S_03046	3.11e-16	72.4	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,1S8VX@1236|Gammaproteobacteria,1XKG5@135619|Oceanospirillales	135619|Oceanospirillales	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_102192_1	288000.BBta_2431	1.16e-71	225.0	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2TSWQ@28211|Alphaproteobacteria,3JTDN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	MA20_26565	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_1022138_1	1304865.JAGF01000001_gene1916	1.94e-102	327.0	COG0085@1|root,COG0085@2|Bacteria,2GJ81@201174|Actinobacteria,4F0Q4@85016|Cellulomonadaceae	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1203360_1	935840.JAEQ01000001_gene2992	2.99e-09	57.4	COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2U06A@28211|Alphaproteobacteria,43GZP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	MA20_19670	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_615385_2	2340.JV46_15090	1.98e-128	377.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,1J4X6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_4393,iECSF_1327.ECSF_4063,iJN746.PP_4889	Adenylsucc_synt
k59_102199_1	344747.PM8797T_27954	8.28e-67	221.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,PRiA4_ORF3,zf-IS66
k59_983206_1	497321.C664_18207	4.88e-54	179.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VJAP@28216|Betaproteobacteria,2KVIW@206389|Rhodocyclales	206389|Rhodocyclales	C	COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_983206_2	1121013.P873_09035	0.000297	43.5	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,1S5XA@1236|Gammaproteobacteria,1X5Z6@135614|Xanthomonadales	135614|Xanthomonadales	O	cytochrome c oxidase assembly protein	cox11	-	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
k59_1730781_1	1121946.AUAX01000026_gene6225	9.83e-33	130.0	COG3899@1|root,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria,4DAX8@85008|Micromonosporales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,DZR,GerE,Guanylate_cyc,Trans_reg_C
k59_1438457_1	1049564.TevJSym_as00020	6.07e-47	168.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1J4JE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0739 Membrane proteins related to metalloendopeptidases	yebA	-	-	-	-	-	-	-	-	-	-	-	OapA,OapA_N,Peptidase_M23
k59_1203369_1	1298593.TOL_3243	1.57e-86	281.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1XHH3@135619|Oceanospirillales	135619|Oceanospirillales	M	penicillin-binding protein	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_45109_1	768671.ThimaDRAFT_4701	5.38e-85	270.0	COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria,1WX8D@135613|Chromatiales	135613|Chromatiales	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_1787989_1	870187.Thini_4190	1.28e-84	268.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,45ZSG@72273|Thiotrichales	72273|Thiotrichales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_1268466_1	367299.JOEE01000004_gene1098	5.12e-18	82.4	COG0473@1|root,COG0473@2|Bacteria,2GK44@201174|Actinobacteria,4FEDG@85021|Intrasporangiaceae	201174|Actinobacteria	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_1268466_2	367299.JOEE01000004_gene1099	3.81e-96	289.0	COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria,4FEYA@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_205123_1	446471.Xcel_2413	3.27e-122	376.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,4F45A@85017|Promicromonosporaceae	201174|Actinobacteria	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	glgX	-	3.2.1.196,3.2.1.68	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02111,R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_983238_1	471853.Bcav_3816	3.05e-154	449.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria	201174|Actinobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	mrpD	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_278092_1	765910.MARPU_04990	4.77e-117	352.0	COG0477@1|root,COG2814@2|Bacteria,1N2NP@1224|Proteobacteria,1RP1Y@1236|Gammaproteobacteria,1WWDI@135613|Chromatiales	135613|Chromatiales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1335438_1	446469.Sked_22830	1.28e-123	362.0	COG0472@1|root,COG0472@2|Bacteria,2GNEH@201174|Actinobacteria	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_674822_1	640081.Dsui_2480	5.46e-45	159.0	COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,2VIYN@28216|Betaproteobacteria,2KYII@206389|Rhodocyclales	206389|Rhodocyclales	P	Periplasmic copper-binding protein (NosD)	-	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
k59_1094217_1	648757.Rvan_0592	3.51e-105	323.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria,3N9EG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,Pyr_redox_2
k59_850548_1	933262.AXAM01000052_gene1993	1.7e-141	405.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,42MBV@68525|delta/epsilon subdivisions,2WIRE@28221|Deltaproteobacteria,2MIFY@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_439497_1	1129794.C427_0212	1.3e-105	321.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,1RQK5@1236|Gammaproteobacteria,464XB@72275|Alteromonadaceae	1236|Gammaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_924192_1	1123057.P872_02000	5.11e-51	179.0	COG4409@1|root,COG4409@2|Bacteria,4NI5M@976|Bacteroidetes,47JYZ@768503|Cytophagia	976|Bacteroidetes	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
k59_1788006_1	227377.CBU_1509	3.89e-40	149.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1JD0N@118969|Legionellales	118969|Legionellales	J	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
k59_1335459_1	1163617.SCD_n01357	5.4e-43	150.0	COG5660@1|root,32WII@2|Bacteria,1R3ME@1224|Proteobacteria	1224|Proteobacteria	S	TRAP transporter T-component	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
k59_675528_1	1121423.JONT01000001_gene2039	4.4e-78	250.0	COG1053@1|root,COG1053@2|Bacteria,1TRE8@1239|Firmicutes,247TH@186801|Clostridia,25ZZD@186807|Peptococcaceae	186801|Clostridia	C	reductase alpha subunit	-	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_45816_1	1232410.KI421417_gene2727	1.33e-20	97.8	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,42N9J@68525|delta/epsilon subdivisions,2X2B8@28221|Deltaproteobacteria,43U8G@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	-	-	-	-	-	-	-	-	-	Toluene_X
k59_925380_2	1043205.AFYF01000030_gene491	3.91e-20	83.6	2ET03@1|root,33KIA@2|Bacteria,2GYQI@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_925380_3	931627.MycrhDRAFT_3323	2.56e-21	89.7	COG1848@1|root,COG1848@2|Bacteria,2HY32@201174|Actinobacteria,23BVV@1762|Mycobacteriaceae	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
k59_147237_2	631362.Thi970DRAFT_02017	6.26e-30	119.0	COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1RSAC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	2CSK_N,HATPase_c
k59_1554967_1	1123269.NX02_27645	7.04e-82	263.0	COG2267@1|root,COG3629@1|root,COG2267@2|Bacteria,COG3629@2|Bacteria,1QU9N@1224|Proteobacteria,2TW44@28211|Alphaproteobacteria,2K7FJ@204457|Sphingomonadales	204457|Sphingomonadales	IT	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_787855_1	882378.RBRH_02235	1.6e-73	235.0	COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,2VGZX@28216|Betaproteobacteria,1K0T5@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	fumarylacetoacetate (FAA) hydrolase	mhpD2	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
k59_1613182_1	367299.JOEE01000001_gene2146	7.02e-94	278.0	COG0081@1|root,COG0081@2|Bacteria,2GM51@201174|Actinobacteria,4FEH9@85021|Intrasporangiaceae	201174|Actinobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_147240_1	1396141.BATP01000005_gene5941	4.07e-72	228.0	COG0476@1|root,COG0476@2|Bacteria,46SGF@74201|Verrucomicrobia,2IU1E@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	ThiF family	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,ThiF
k59_925389_1	1125971.ASJB01000031_gene1287	1.56e-100	301.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,4E12D@85010|Pseudonocardiales	201174|Actinobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_734148_2	998674.ATTE01000001_gene1310	7.05e-21	91.7	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed	yqeF	GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034308,GO:0034309,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046165,GO:0046395,GO:0055114,GO:0071270,GO:0071271,GO:0071704,GO:0072329,GO:1901575,GO:1901576,GO:1901615,GO:1901617	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iSSON_1240.SSON_3004	Thiolase_C,Thiolase_N
k59_557474_1	395965.Msil_1042	1.34e-52	182.0	COG2267@1|root,COG2267@2|Bacteria,1QTZP@1224|Proteobacteria,2U1G2@28211|Alphaproteobacteria,3NABB@45404|Beijerinckiaceae	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
k59_616077_1	1047013.AQSP01000086_gene2010	8.39e-71	224.0	COG0050@1|root,COG0050@2|Bacteria,2NNQV@2323|unclassified Bacteria	2|Bacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_616077_2	204669.Acid345_1225	8.31e-15	69.3	COG0051@1|root,COG0051@2|Bacteria,3Y4V5@57723|Acidobacteria,2JJAS@204432|Acidobacteriia	204432|Acidobacteriia	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
k59_211567_1	1305735.JAFT01000005_gene1280	1.32e-07	53.5	COG1028@1|root,COG1028@2|Bacteria,1MVYJ@1224|Proteobacteria,2TRJ8@28211|Alphaproteobacteria,2PDRP@252301|Oceanicola	28211|Alphaproteobacteria	IQ	KR domain	rhlG	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_211567_2	760117.JN27_06975	2.93e-10	60.8	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2VK0U@28216|Betaproteobacteria,473CM@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_1679779_1	1283300.ATXB01000001_gene2163	2.13e-40	141.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,1S9DV@1236|Gammaproteobacteria,1XFD6@135618|Methylococcales	135618|Methylococcales	P	subunit of a heme lyase	ccmH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
k59_1679779_2	1049564.TevJSym_ad01630	2.43e-85	274.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1RZEA@1236|Gammaproteobacteria,1JBT5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Cytochrome c-type biogenesis protein	ccmI	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8
k59_1679779_3	1049564.TevJSym_ak00320	3.45e-24	98.6	2FHYC@1|root,349RC@2|Bacteria,1P31R@1224|Proteobacteria,1SRZR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_1679779_4	1430440.MGMSRv2_2156	2.7e-55	186.0	COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,2V6WW@28211|Alphaproteobacteria,2JRJU@204441|Rhodospirillales	204441|Rhodospirillales	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_792480_2	246197.MXAN_7143	3.34e-47	166.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YU6E@29|Myxococcales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_504569_1	1232410.KI421422_gene2071	1.81e-89	286.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,43S73@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1560848_1	446469.Sked_15620	1.04e-92	283.0	COG1104@1|root,COG1104@2|Bacteria,2GJ2B@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the sulfur carrier protein TusA family	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5,TusA
k59_856824_1	1123065.ATWL01000005_gene1375	1.27e-30	117.0	COG1214@1|root,COG1214@2|Bacteria,2GMTM@201174|Actinobacteria	201174|Actinobacteria	O	PFAM Peptidase M22, glycoprotease	yeaZ	GO:0002949,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
k59_112387_2	555778.Hneap_0498	6.9e-32	127.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1WVXZ@135613|Chromatiales	135613|Chromatiales	MU	type I secretion outer membrane protein, TolC	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
k59_1027960_1	1112214.AHIS01000110_gene3929	2.81e-23	98.6	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,2U450@28211|Alphaproteobacteria,2K4T7@204457|Sphingomonadales	204457|Sphingomonadales	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PP2C,PP2C_2
k59_792493_1	1089551.KE386572_gene3942	7.19e-28	116.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,4BRP9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Trypsin	degPch1	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_1873986_1	568706.BN118_1299	4.84e-41	147.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VIK8@28216|Betaproteobacteria,3T1W4@506|Alcaligenaceae	28216|Betaproteobacteria	BQ	Deacetylases including yeast histone deacetylase and acetoin utilization protein	hdaH	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_1873986_2	933262.AXAM01000038_gene898	7.51e-24	97.1	COG3640@1|root,COG3640@2|Bacteria,1R819@1224|Proteobacteria,42PQR@68525|delta/epsilon subdivisions,2WKE4@28221|Deltaproteobacteria,2MIKC@213118|Desulfobacterales	28221|Deltaproteobacteria	D	PFAM Cobyrinic acid ac-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
k59_112400_1	367299.JOEE01000011_gene3212	1.69e-05	46.2	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4FF22@85021|Intrasporangiaceae	201174|Actinobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	sprI	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
k59_112400_2	367299.JOEE01000011_gene3213	2.68e-53	174.0	COG1826@1|root,COG1826@2|Bacteria,2IR0U@201174|Actinobacteria,4FHHW@85021|Intrasporangiaceae	201174|Actinobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	GO:0008150,GO:0040007	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_445935_1	435908.IDSA_07940	3.75e-40	150.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,2QF1T@267893|Idiomarinaceae	1236|Gammaproteobacteria	I	Phospholipase D. Active site motifs.	clsC	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:0090483,GO:1901576	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_856840_2	765912.Thimo_2636	8.85e-21	91.3	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,1RQZJ@1236|Gammaproteobacteria,1WX5R@135613|Chromatiales	135613|Chromatiales	I	aromatic hydrocarbon degradation	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_405907_1	1249627.D779_1436	9.09e-78	245.0	COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,1WW5X@135613|Chromatiales	135613|Chromatiales	J	Elongation factor P--(R)-beta-lysine ligase	-	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
k59_1101224_1	765911.Thivi_0936	6.88e-77	243.0	COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1WWZ8@135613|Chromatiales	135613|Chromatiales	S	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_1793662_1	1151122.AQYD01000007_gene665	6.15e-35	145.0	COG2911@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG4625@1|root,COG4932@1|root,COG5373@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,COG4625@2|Bacteria,COG4932@2|Bacteria,COG5373@2|Bacteria	2|Bacteria	KLT	membrane	-	-	-	ko:K02451,ko:K03832,ko:K13735,ko:K20276,ko:K21449	ko02024,ko05100,map02024,map05100	M00331	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	1.B.40.2,2.C.1.1,9.B.42	-	-	PATR,T2SSB
k59_112428_1	1167006.UWK_01719	4.25e-18	79.3	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,42N6H@68525|delta/epsilon subdivisions,2WNG7@28221|Deltaproteobacteria,2MHWW@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
k59_328926_1	227086.JGI_V11_85454	3.44e-09	57.8	COG0059@1|root,2QQBF@2759|Eukaryota	2759|Eukaryota	EH	ketol-acid reductoisomerase activity	ILV5	GO:0000002,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004455,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006549,GO:0006551,GO:0006573,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009295,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0031974,GO:0042645,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0055114,GO:0070013,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	iMM904.YLR355C,iND750.YLR355C	IlvC,IlvN
k59_328926_2	694440.JOMF01000004_gene1257	1.67e-42	147.0	COG1469@1|root,arCOG04301@2157|Archaea,2XT11@28890|Euryarchaeota,2N944@224756|Methanomicrobia	224756|Methanomicrobia	H	Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin	mptA	-	3.5.4.39	ko:K17488	ko00790,map00790	-	R10348	RC02504,RC03131	ko00000,ko00001,ko01000	-	-	-	GCHY-1
k59_1679822_1	1269813.ATUL01000021_gene748	7.43e-129	373.0	COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,1RMS7@1236|Gammaproteobacteria,1WWCG@135613|Chromatiales	135613|Chromatiales	C	PFAM Phosphoribulokinase uridine kinase	-	-	2.7.1.19	ko:K00855	ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200	M00165,M00166	R01523	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
k59_1275840_1	1267005.KB911258_gene601	2.83e-105	315.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TR32@28211|Alphaproteobacteria,3N6JQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_934188_1	67352.JODS01000005_gene6241	2.27e-18	91.3	COG0845@1|root,COG1579@1|root,COG0845@2|Bacteria,COG1579@2|Bacteria,2H3CU@201174|Actinobacteria	201174|Actinobacteria	M	Zn-ribbon protein possibly nucleic acid-binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1619096_1	367299.JOEE01000001_gene1848	1.03e-76	244.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4FEWA@85021|Intrasporangiaceae	201174|Actinobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_993444_1	1121935.AQXX01000109_gene480	2.68e-205	601.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1XHSN@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_1345789_1	1333856.L686_04220	5.67e-17	84.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1YZRR@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	mltF	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030203,GO:0030312,GO:0030313,GO:0031975,GO:0043170,GO:0044462,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	iBWG_1329.BWG_2322,iEC042_1314.EC042_2762,iECDH1ME8569_1439.ECDH1ME8569_2485,iECNA114_1301.ECNA114_2631,iECP_1309.ECP_2560,iECSF_1327.ECSF_2397,iECW_1372.ECW_m2786,iEKO11_1354.EKO11_1175,iEcDH1_1363.EcDH1_1110,iEcHS_1320.EcHS_A2711,iEcolC_1368.EcolC_1119,iG2583_1286.G2583_3089,iJO1366.b2558,iSFxv_1172.SFxv_2861,iUMN146_1321.UM146_03930,iUMNK88_1353.UMNK88_3212,iUTI89_1310.UTI89_C2878,iWFL_1372.ECW_m2786,iY75_1357.Y75_RS13345	SBP_bac_3,SLT
k59_681502_1	743718.Isova_2933	2.76e-73	234.0	COG2265@1|root,COG2265@2|Bacteria,2GP90@201174|Actinobacteria,4F386@85017|Promicromonosporaceae	201174|Actinobacteria	H	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumB	-	2.1.1.189	ko:K03212	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	tRNA_U5-meth_tr
k59_1511107_1	1122176.KB903565_gene3328	2.54e-100	317.0	COG0243@1|root,COG0243@2|Bacteria,4NITD@976|Bacteroidetes	976|Bacteroidetes	C	Molybdopterin oxidoreductase	-	-	1.7.2.3,1.8.5.5	ko:K07812,ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.4,5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1276904_1	136273.GY22_03860	4.45e-53	183.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,1W8QK@1268|Micrococcaceae	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_505591_2	713586.KB900536_gene1100	7.17e-199	576.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1WW5E@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1276905_1	472759.Nhal_2385	2.72e-21	89.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,1RMK9@1236|Gammaproteobacteria,1WVZS@135613|Chromatiales	135613|Chromatiales	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_1276905_2	765910.MARPU_03725	5.25e-60	190.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,1WW16@135613|Chromatiales	135613|Chromatiales	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_1561753_1	765913.ThidrDRAFT_1560	2.14e-111	338.0	COG0772@1|root,COG0772@2|Bacteria,1R537@1224|Proteobacteria,1RR9J@1236|Gammaproteobacteria,1WWS3@135613|Chromatiales	135613|Chromatiales	D	Belongs to the SEDS family	-	-	-	-	-	-	-	-	-	-	-	-	FTSW_RODA_SPOVE
k59_1875382_1	1528106.JRJE01000008_gene1488	2.36e-59	194.0	COG3386@1|root,COG3386@2|Bacteria,1MVQM@1224|Proteobacteria,2U3TF@28211|Alphaproteobacteria,2JT56@204441|Rhodospirillales	204441|Rhodospirillales	G	SMP-30/Gluconolaconase/LRE-like region	-	-	-	-	-	-	-	-	-	-	-	-	SGL
k59_793249_1	367299.JOEE01000007_gene31	7.83e-72	231.0	COG0074@1|root,COG0074@2|Bacteria,2GN20@201174|Actinobacteria,4FE7B@85021|Intrasporangiaceae	201174|Actinobacteria	C	FdrA family	-	-	-	ko:K02381	-	-	-	-	ko00000	-	-	-	CoA_binding,Ligase_CoA
k59_1794528_1	395493.BegalDRAFT_0893	3.41e-08	52.8	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1T09C@1236|Gammaproteobacteria,463TP@72273|Thiotrichales	72273|Thiotrichales	NU	Type II secretion system (T2SS), protein G	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,T2SSG
k59_1794528_2	1415780.JPOG01000001_gene1324	3.37e-25	102.0	COG2165@1|root,COG2165@2|Bacteria,1N2DZ@1224|Proteobacteria,1T5SG@1236|Gammaproteobacteria,1X7WS@135614|Xanthomonadales	135614|Xanthomonadales	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	GspH,N_methyl
k59_407339_1	1279015.KB908461_gene1813	9.73e-24	98.6	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1Y42E@135624|Aeromonadales	135624|Aeromonadales	M	Arabinose 5-phosphate isomerase	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
k59_407339_2	2340.JV46_29440	4.63e-85	254.0	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,1J685@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate	kdsC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008781,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016311,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016791,GO:0019143,GO:0033692,GO:0034637,GO:0034645,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iECO26_1355.ECO26_4302	Hydrolase_3
k59_1875401_1	1134474.O59_001871	3.49e-64	217.0	COG0339@1|root,COG0339@2|Bacteria,1R4AJ@1224|Proteobacteria,1S0F2@1236|Gammaproteobacteria,1FFXH@10|Cellvibrio	1236|Gammaproteobacteria	E	Peptidase family M3	-	-	3.4.24.15	ko:K01392	ko04614,ko05143,map04614,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M3
k59_564173_1	1121434.AULY01000009_gene2097	1.17e-59	201.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria,2M8ZR@213115|Desulfovibrionales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_288390_1	1172188.KB911820_gene2201	1.28e-100	314.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria,4FFS7@85021|Intrasporangiaceae	201174|Actinobacteria	O	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1794546_1	266264.Rmet_3809	5.59e-13	70.9	COG1804@1|root,COG1804@2|Bacteria,1MU4A@1224|Proteobacteria,2VJ1I@28216|Betaproteobacteria	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_1794546_2	1121022.ABENE_18090	2.88e-19	82.4	COG4430@1|root,COG4430@2|Bacteria,1N8ME@1224|Proteobacteria,2UT29@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905,OmdA
k59_329969_1	187272.Mlg_1311	1.44e-49	166.0	COG1136@1|root,COG1136@2|Bacteria,1NCFC@1224|Proteobacteria,1S2XY@1236|Gammaproteobacteria,1WYES@135613|Chromatiales	135613|Chromatiales	V	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_329969_2	472759.Nhal_1408	6.33e-28	117.0	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,1RNP1@1236|Gammaproteobacteria,1WWFF@135613|Chromatiales	135613|Chromatiales	V	ABC-type transport system, involved in lipoprotein release, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_55573_1	706191.PANA_1339	1.13e-49	169.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,3VYGF@53335|Pantoea	1236|Gammaproteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	GO:0000166,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	iPC815.YPO1374	Pyr_redox_2
k59_55573_2	435908.IDSA_04240	5.99e-12	68.6	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,2QFRD@267893|Idiomarinaceae	1236|Gammaproteobacteria	D	Ftsk_gamma	ftsK	GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1875424_1	1341646.CBMO010000059_gene1670	5.66e-112	336.0	COG1474@1|root,COG1474@2|Bacteria,2HM4W@201174|Actinobacteria,2354P@1762|Mycobacteriaceae	201174|Actinobacteria	LO	P-loop Domain of unknown function (DUF2791)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2791
k59_1029465_1	933262.AXAM01000019_gene1125	2.08e-33	124.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,42RIC@68525|delta/epsilon subdivisions,2WNRX@28221|Deltaproteobacteria,2MJS6@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_1029465_2	1211817.CCAT010000083_gene1491	2.01e-07	51.6	COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,2480Q@186801|Clostridia,36FTT@31979|Clostridiaceae	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS11880	GDC-P
k59_113850_1	251229.Chro_4538	3.88e-05	52.4	COG0028@1|root,COG0028@2|Bacteria,1G2XN@1117|Cyanobacteria	1117|Cyanobacteria	EH	Belongs to the TPP enzyme family	-	-	4.1.1.7	ko:K01576	ko00627,ko01120,map00627,map01120	-	R01764,R02672	RC00595	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1794559_1	883.DvMF_1987	2.64e-66	226.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WIXV@28221|Deltaproteobacteria,2M800@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Pyruvate phosphate dikinase, PEP	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
k59_329992_1	1305836.AXVE01000011_gene959	1.43e-37	137.0	COG3268@1|root,COG3268@2|Bacteria,1UYDT@1239|Firmicutes,4HCS8@91061|Bacilli,26EHD@186818|Planococcaceae	91061|Bacilli	S	Saccharopine dehydrogenase NADP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
k59_935473_1	768671.ThimaDRAFT_4705	1.24e-87	276.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria,1WWCP@135613|Chromatiales	135613|Chromatiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_1620007_2	258052.JNYV01000004_gene4551	5.52e-61	194.0	COG0288@1|root,COG0288@2|Bacteria,2GM1M@201174|Actinobacteria,2M1IJ@2063|Kitasatospora	201174|Actinobacteria	P	Carbonic anhydrase	mtcA1	GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008270,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0040007,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
k59_1620007_3	864069.MicloDRAFT_00017940	7.86e-72	221.0	COG1670@1|root,COG1670@2|Bacteria,1RHBD@1224|Proteobacteria,2U925@28211|Alphaproteobacteria,1JY09@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_1347241_1	1415756.JQMY01000001_gene2177	8.6e-54	191.0	COG3391@1|root,COG3391@2|Bacteria,1MXN7@1224|Proteobacteria,2TR83@28211|Alphaproteobacteria,2PDQH@252301|Oceanicola	28211|Alphaproteobacteria	S	GTA TIM-barrel-like domain	-	-	-	-	-	-	-	-	-	-	-	-	GTA_TIM,Phage-tail_3
k59_154267_1	1123242.JH636434_gene3794	3.36e-126	371.0	COG0686@1|root,COG0686@2|Bacteria,2IXPP@203682|Planctomycetes	203682|Planctomycetes	C	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_1029480_1	1132441.KI519455_gene2517	3.31e-31	119.0	COG0454@1|root,COG0456@2|Bacteria,2IMS5@201174|Actinobacteria,1W9YS@1268|Micrococcaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0044424,GO:0044464,GO:0048583,GO:0050789,GO:0065007,GO:0080134,GO:1902882	2.3.1.57	ko:K22441	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
k59_505666_1	1265507.KB899636_gene1134	6.08e-18	82.8	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RMN3@1236|Gammaproteobacteria,1Y3NR@135624|Aeromonadales	135624|Aeromonadales	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_505666_2	1122165.AUHS01000008_gene1094	3.82e-52	183.0	COG0019@1|root,COG0527@1|root,COG0019@2|Bacteria,COG0527@2|Bacteria,1MUA6@1224|Proteobacteria,1SZXB@1236|Gammaproteobacteria,1JD6X@118969|Legionellales	118969|Legionellales	E	Belongs to the Orn Lys Arg decarboxylase class-II family	lysAC	-	2.7.2.4,4.1.1.20	ko:K12526	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00451,R00480	RC00002,RC00043,RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_1386033_2	593907.Celgi_1656	5.7e-77	237.0	COG1386@1|root,COG1386@2|Bacteria,2GISY@201174|Actinobacteria,4F166@85016|Cellulomonadaceae	201174|Actinobacteria	K	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
k59_1386033_3	446466.Cfla_1928	1.03e-22	95.1	COG1187@1|root,COG1187@2|Bacteria,2GJ4N@201174|Actinobacteria,4F0IE@85016|Cellulomonadaceae	201174|Actinobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_1102406_1	429009.Adeg_0355	2.87e-73	231.0	COG1180@1|root,COG1180@2|Bacteria,1V170@1239|Firmicutes,24E3W@186801|Clostridia,42HNZ@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_154274_1	1485544.JQKP01000011_gene711	6.38e-59	192.0	COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,2VHPX@28216|Betaproteobacteria,44VPD@713636|Nitrosomonadales	28216|Betaproteobacteria	N	PFAM MotA TolQ ExbB proton channel	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
k59_935493_1	1027273.GZ77_17940	4.98e-92	285.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XHFG@135619|Oceanospirillales	135619|Oceanospirillales	T	regulator	hydG	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Sigma54_activat
k59_113884_1	450380.JPSY01000001_gene1186	3.95e-64	216.0	29GCA@1|root,303A5@2|Bacteria,2H1W0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_994759_1	471853.Bcav_2453	8.31e-103	340.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria	201174|Actinobacteria	L	dead DEAH box helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
k59_1875467_1	1304865.JAGF01000001_gene1582	1.46e-24	103.0	COG0842@1|root,COG0842@2|Bacteria,2GN6S@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_1875467_2	1304865.JAGF01000001_gene1581	9.38e-98	292.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,4F1V0@85016|Cellulomonadaceae	201174|Actinobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_55614_1	401053.AciPR4_1492	1.34e-50	180.0	COG0591@1|root,COG0591@2|Bacteria,3Y42K@57723|Acidobacteria,2JI5Z@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
k59_1347267_1	298655.KI912266_gene1731	4.58e-59	193.0	COG2222@1|root,COG2222@2|Bacteria,2IBP7@201174|Actinobacteria	201174|Actinobacteria	M	sugar isomerase	-	-	-	-	-	-	-	-	-	-	-	-	SIS
k59_935507_2	460265.Mnod_2880	1.43e-07	53.1	COG2979@1|root,COG2979@2|Bacteria,1R95E@1224|Proteobacteria,2VA34@28211|Alphaproteobacteria,1JY8K@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF533)	-	-	-	-	-	-	-	-	-	-	-	-	DUF533
k59_1221561_1	768671.ThimaDRAFT_4072	4.41e-51	176.0	28KQH@1|root,2ZA8A@2|Bacteria,1R5EQ@1224|Proteobacteria,1RRD9@1236|Gammaproteobacteria,1WXTM@135613|Chromatiales	135613|Chromatiales	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
k59_515414_1	670307.HYPDE_28348	3.63e-99	299.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,2TSE4@28211|Alphaproteobacteria,3N7KJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Belongs to the HypD family	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
k59_574264_1	384765.SIAM614_16427	3.48e-116	345.0	COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2TS0X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	nasF	-	-	ko:K15576	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	NMT1_2
k59_1041832_1	1266914.ATUK01000012_gene209	6.81e-16	72.0	COG2168@1|root,COG2168@2|Bacteria,1NGF3@1224|Proteobacteria,1SGPI@1236|Gammaproteobacteria,1WYI4@135613|Chromatiales	135613|Chromatiales	P	sulfur relay protein TusB DsrH	-	-	-	ko:K07237	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DsrH
k59_223245_1	631362.Thi970DRAFT_00712	4.94e-35	131.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1WWKX@135613|Chromatiales	135613|Chromatiales	LU	TIGRFAM DNA protecting protein DprA	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_223245_2	1260251.SPISAL_00265	4.62e-12	64.3	COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1WYZ6@135613|Chromatiales	135613|Chromatiales	S	Belongs to the Smg family	smg	-	-	ko:K03747	-	-	-	-	ko00000	-	-	-	DUF494
k59_633347_1	1267005.KB911260_gene3577	9.47e-86	275.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2TRC1@28211|Alphaproteobacteria,3N6K7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	RNB,S1
k59_341017_1	395493.BegalDRAFT_2421	2.7e-13	70.1	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,45ZY4@72273|Thiotrichales	72273|Thiotrichales	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_341017_2	522306.CAP2UW1_4011	3.13e-28	116.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2VH8D@28216|Betaproteobacteria,1KQCI@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Peptidase M16 inactive domain	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_869338_1	686340.Metal_1017	1.24e-42	145.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,1RRFJ@1236|Gammaproteobacteria,1XE2F@135618|Methylococcales	135618|Methylococcales	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
k59_869338_2	1049564.TevJSym_ad01710	3.57e-80	244.0	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,1S3R2@1236|Gammaproteobacteria,1J6FA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015232,GO:0015886,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019897,GO:0019898,GO:0022857,GO:0031224,GO:0031234,GO:0032991,GO:0042623,GO:0043190,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:1901678,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	iAPECO1_1312.APECO1_4358,iECED1_1282.ECED1_2666,iECS88_1305.ECS88_2348,iECUMN_1333.ECUMN_2536,iLF82_1304.LF82_0273,iNRG857_1313.NRG857_11170,iUMN146_1321.UM146_05800,iUTI89_1310.UTI89_C2479	ABC_tran
k59_692852_1	323097.Nham_3058	1.53e-08	57.0	COG3547@1|root,COG3547@2|Bacteria,1Q4TE@1224|Proteobacteria,2TT7C@28211|Alphaproteobacteria,3JUK3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1524208_1	1121405.dsmv_3752	1.23e-122	358.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,42MB0@68525|delta/epsilon subdivisions,2WJ42@28221|Deltaproteobacteria,2MI3B@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_1415	Phe_tRNA-synt_N,tRNA-synt_2d
k59_752107_1	1049564.TevJSym_aa02140	1.73e-50	176.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,1RPKA@1236|Gammaproteobacteria,1J6IQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	MOFRL family	ttuD	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
k59_752107_2	323261.Noc_2112	2.34e-87	268.0	COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,1RNGA@1236|Gammaproteobacteria,1WX4Y@135613|Chromatiales	135613|Chromatiales	G	Protein of unknown function (DUF455)	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF455
k59_1524209_1	983545.Glaag_0279	2.62e-70	231.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,1RMCN@1236|Gammaproteobacteria,463Y7@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG0659 Sulfate permease and related transporters (MFS superfamily)	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_574281_1	448385.sce7733	1.37e-64	222.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WJ2H@28221|Deltaproteobacteria,2YX1T@29|Myxococcales	28221|Deltaproteobacteria	H	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_633357_2	522306.CAP2UW1_3863	5.85e-30	122.0	COG1008@1|root,COG1008@2|Bacteria,1R6UV@1224|Proteobacteria,2VHFZ@28216|Betaproteobacteria,1KR8C@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1572837_1	1158762.KB898051_gene869	6.81e-95	303.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WVYX@135613|Chromatiales	135613|Chromatiales	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_165138_1	765912.Thimo_0783	2.16e-38	140.0	28PII@1|root,2ZC8H@2|Bacteria,1R6MG@1224|Proteobacteria,1RZZF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF4255)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4255
k59_1396625_2	555778.Hneap_2051	5.88e-86	276.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1WWSJ@135613|Chromatiales	135613|Chromatiales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_1524245_1	666681.M301_1046	9.83e-25	96.7	COG3450@1|root,COG3450@2|Bacteria	2|Bacteria	I	Protein of unknown function (DUF861)	-	-	-	ko:K06995	-	-	-	-	ko00000	-	-	-	Cupin_3
k59_1524245_2	1117314.PCIT_01610	8.89e-15	72.8	2DBI4@1|root,2Z9EH@2|Bacteria,1MXNH@1224|Proteobacteria,1RT1Y@1236|Gammaproteobacteria,2Q0EN@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
k59_1156788_1	1232683.ADIMK_3339	1.45e-52	185.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,1RNCM@1236|Gammaproteobacteria,464B9@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs	-	-	1.3.99.16	ko:K00256,ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,TAT_signal
k59_1524256_1	1167006.UWK_02851	2.85e-65	218.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2MIKT@213118|Desulfobacterales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	-	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_topoisoIV
k59_515457_1	1047013.AQSP01000119_gene1293	2.13e-96	300.0	COG1154@1|root,COG1154@2|Bacteria,2NNNA@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0008661,GO:0009058,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030145,GO:0030975,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901363,GO:1901576,GO:1901681	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_456986_1	367299.JOEE01000005_gene3567	3.53e-92	286.0	COG4177@1|root,COG4177@2|Bacteria,2GJB3@201174|Actinobacteria,4FFQT@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_633395_1	471853.Bcav_2905	2.75e-76	234.0	COG3396@1|root,COG3396@2|Bacteria,2GKXZ@201174|Actinobacteria	201174|Actinobacteria	S	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like	-	-	-	-	-	-	-	-	-	-	-	-	MiaE_2
k59_1803737_1	593907.Celgi_2058	2.52e-83	262.0	COG0595@1|root,COG0595@2|Bacteria,2GIW7@201174|Actinobacteria,4F0MZ@85016|Cellulomonadaceae	201174|Actinobacteria	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
k59_1221649_1	1500893.JQNB01000001_gene1280	3.79e-75	253.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1X465@135614|Xanthomonadales	135614|Xanthomonadales	E	Glutamate synthase	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_341081_1	522306.CAP2UW1_2119	1.36e-07	57.4	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,2VPHG@28216|Betaproteobacteria	28216|Betaproteobacteria	KLT	peptidase C14 caspase catalytic subunit p20	prkC1	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Pkinase,SHOCT
k59_341081_2	1158146.KB907123_gene581	1.15e-09	60.8	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RM8C@1236|Gammaproteobacteria,1WWUM@135613|Chromatiales	135613|Chromatiales	E	PFAM Orn DAP Arg decarboxylase 2	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_1396664_1	1178482.BJB45_09215	7.12e-55	185.0	COG0673@1|root,COG0673@2|Bacteria,1MXDE@1224|Proteobacteria,1RREC@1236|Gammaproteobacteria,1XND3@135619|Oceanospirillales	135619|Oceanospirillales	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_1749081_1	156889.Mmc1_1073	2.19e-70	224.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2TR4T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_1290262_1	472759.Nhal_3413	1e-98	293.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1S032@1236|Gammaproteobacteria,1X250@135613|Chromatiales	135613|Chromatiales	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_692932_1	1255043.TVNIR_2412	1.55e-53	180.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,1RQI4@1236|Gammaproteobacteria,1WZEX@135613|Chromatiales	135613|Chromatiales	H	DinB superfamily	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	DinB_2,FGE-sulfatase
k59_692932_2	1255043.TVNIR_2410	4.95e-44	152.0	COG0438@1|root,COG0438@2|Bacteria,1RB3J@1224|Proteobacteria,1RW61@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0438 Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
k59_1041982_1	1267005.KB911259_gene3816	6.35e-125	367.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2TQUS@28211|Alphaproteobacteria,3N6AT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
k59_1156831_1	314278.NB231_06296	3.51e-22	94.4	COG1763@1|root,COG1763@2|Bacteria,1QYTH@1224|Proteobacteria,1T3U1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Mo-molybdopterin cofactor biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1156831_2	472759.Nhal_2659	2.63e-23	97.8	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,1RQ15@1236|Gammaproteobacteria,1X0JQ@135613|Chromatiales	135613|Chromatiales	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1221680_1	380703.AHA_2273	3.74e-46	162.0	COG1752@1|root,COG1752@2|Bacteria,1R7RX@1224|Proteobacteria,1RRTH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_1524338_1	443143.GM18_4033	5.75e-41	154.0	COG1729@1|root,COG1729@2|Bacteria,1MX82@1224|Proteobacteria,42TQ9@68525|delta/epsilon subdivisions,2WR3B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
k59_1457091_1	1386089.N865_05750	3.3e-26	107.0	COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria,4FE3G@85021|Intrasporangiaceae	201174|Actinobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_165240_1	47716.JOFH01000032_gene7241	4.18e-38	132.0	COG2030@1|root,COG2030@2|Bacteria,2IFCJ@201174|Actinobacteria	201174|Actinobacteria	I	dehydratase	hadB	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
k59_165240_2	926564.KI911686_gene5557	7.99e-42	142.0	COG2030@1|root,COG2030@2|Bacteria,2GMVC@201174|Actinobacteria,4F4H1@85017|Promicromonosporaceae	201174|Actinobacteria	I	N-terminal half of MaoC dehydratase	hadA	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
k59_341123_1	1267534.KB906754_gene3465	2.76e-29	117.0	COG0491@1|root,COG0491@2|Bacteria,3Y54H@57723|Acidobacteria,2JM9F@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1042018_1	1035308.AQYY01000002_gene794	1.28e-100	298.0	COG1175@1|root,COG1175@2|Bacteria,1TQX5@1239|Firmicutes,24B1Z@186801|Clostridia	186801|Clostridia	P	abc transporter permease protein	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
k59_1803784_2	1122247.C731_0398	2.03e-07	52.0	COG0296@1|root,COG0296@2|Bacteria,2GJ5C@201174|Actinobacteria,234A0@1762|Mycobacteriaceae	201174|Actinobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0055114,GO:0071704,GO:0071944,GO:1901576	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_1457113_1	322710.Avin_39140	1.22e-49	179.0	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,1S08E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Pfam Glycosyl transferase family 2	bcsA	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_17,Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,PilZ
k59_801453_1	382464.ABSI01000005_gene1274	8.64e-25	108.0	COG1283@1|root,COG1283@2|Bacteria,46SD7@74201|Verrucomicrobia,2IVEH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Na+/Pi-cotransporter	-	-	-	-	-	-	-	-	-	-	-	-	Na_Pi_cotrans
k59_869498_1	338969.Rfer_1886	1.09e-83	272.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,2VHXU@28216|Betaproteobacteria,4ACAW@80864|Comamonadaceae	28216|Betaproteobacteria	P	Cytochrome C and Quinol oxidase polypeptide I	norB	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
k59_1631128_1	1121405.dsmv_2298	9.66e-44	161.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MIWX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CoA-binding domain protein	acs	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1803794_1	95619.PM1_0213410	1e-81	268.0	COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,1S28B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	nucleotidyltransferase DNA polymerase involved in DNA repair	imuB	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
k59_869521_1	1121405.dsmv_1745	6.54e-73	231.0	COG0620@1|root,COG0620@2|Bacteria,1R6KI@1224|Proteobacteria,42PCN@68525|delta/epsilon subdivisions,2WKT3@28221|Deltaproteobacteria,2MID3@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_694329_3	713586.KB900536_gene2226	4.17e-132	405.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
k59_871129_1	1236541.BALL01000001_gene203	4.31e-53	179.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,2Q9BN@267890|Shewanellaceae	1236|Gammaproteobacteria	V	PFAM ABC transporter related	ybhF	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_871129_2	400668.Mmwyl1_0873	6.83e-26	107.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1XHBH@135619|Oceanospirillales	135619|Oceanospirillales	U	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_1632787_1	1167006.UWK_03323	3.5e-29	117.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,42N2X@68525|delta/epsilon subdivisions,2X7GJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1398224_2	1095767.CAHD01000001_gene2417	1.02e-06	51.2	COG0596@1|root,COG0596@2|Bacteria,2GNFU@201174|Actinobacteria,4F175@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
k59_458260_1	713586.KB900536_gene118	2.79e-81	257.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1WWJ8@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_1223270_1	614083.AWQR01000009_gene553	1.87e-62	197.0	COG4929@1|root,COG4929@2|Bacteria,1MZW2@1224|Proteobacteria,2VKF7@28216|Betaproteobacteria,4AFRH@80864|Comamonadaceae	28216|Betaproteobacteria	S	GDYXXLXY protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157,DUF4401,GDYXXLXY
k59_1223273_1	652103.Rpdx1_1850	5.09e-25	108.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria,3JQMS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	UvrD-like helicase C-terminal domain	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1574634_1	1217720.ALOX01000027_gene3613	2.17e-20	90.1	COG0028@1|root,COG4032@1|root,COG0028@2|Bacteria,COG4032@2|Bacteria,1R6QP@1224|Proteobacteria,2TUEF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase	-	-	4.1.1.82	ko:K09459	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R04053	RC00506	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
k59_1574634_2	323261.Noc_1317	8.62e-27	109.0	COG1213@1|root,COG2513@1|root,COG1213@2|Bacteria,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,1RY5Q@1236|Gammaproteobacteria,1X09Q@135613|Chromatiales	135613|Chromatiales	C	Phosphoenolpyruvate phosphomutase	-	-	5.4.2.9	ko:K01841	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R00661	RC02792	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3,PEP_mutase
k59_1398232_1	1499967.BAYZ01000028_gene1229	3.12e-27	108.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_516489_1	1117943.SFHH103_02371	1.79e-70	224.0	COG0332@1|root,COG0332@2|Bacteria,1N6Z0@1224|Proteobacteria,2U1G4@28211|Alphaproteobacteria,4B72B@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	3-oxoacyl- acyl-carrier-protein synthase III	fabH2	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_753747_1	1049564.TevJSym_aa00630	8.72e-37	138.0	COG0642@1|root,COG0642@2|Bacteria,1PA1G@1224|Proteobacteria,1T1HX@1236|Gammaproteobacteria,1JC34@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_694352_1	932677.PAJ_3006	2.58e-52	169.0	COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,1S2DE@1236|Gammaproteobacteria,3VYBJ@53335|Pantoea	1236|Gammaproteobacteria	S	UPF0114 protein	yqhA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	UPF0114
k59_458279_1	706587.Desti_0167	1.62e-110	334.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42MZJ@68525|delta/epsilon subdivisions,2WJK1@28221|Deltaproteobacteria,2MQ7S@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_871169_1	396588.Tgr7_2304	1.53e-186	531.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1WWJA@135613|Chromatiales	135613|Chromatiales	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_166779_1	1380394.JADL01000001_gene2175	7.53e-19	80.9	COG2146@1|root,COG2146@2|Bacteria,1N72F@1224|Proteobacteria,2UFDN@28211|Alphaproteobacteria,2JTWK@204441|Rhodospirillales	204441|Rhodospirillales	P	COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_166779_2	765912.Thimo_2738	2.1e-115	342.0	COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,1RNZF@1236|Gammaproteobacteria,1WXRH@135613|Chromatiales	135613|Chromatiales	S	PFAM Bile acid sodium symporter	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
k59_1173983_2	96561.Dole_1504	1.62e-32	116.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,42RVK@68525|delta/epsilon subdivisions,2WNNA@28221|Deltaproteobacteria,2MJSM@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
k59_1819094_2	2340.JV46_20390	4.09e-23	99.4	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1J4U3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CP	CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	nuoL	-	1.6.5.3	ko:K00341,ko:K05559	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_1174011_1	160488.PP_1870	9.77e-05	45.4	COG0500@1|root,COG0500@2|Bacteria,1RAE4@1224|Proteobacteria,1S0RC@1236|Gammaproteobacteria,1YVGJ@136845|Pseudomonas putida group	1236|Gammaproteobacteria	H	Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family	tpm	GO:0003674,GO:0003824,GO:0008119,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008757,GO:0010035,GO:0010038,GO:0016740,GO:0016741,GO:0032259,GO:0042221,GO:0046690,GO:0050896	2.1.1.67	ko:K00569	ko00983,map00983	-	R08236,R08239,R08246	RC00003,RC00980,RC02277	ko00000,ko00001,ko01000	-	-	-	TPMT
k59_1174011_2	686340.Metal_2787	4.88e-43	152.0	COG2403@1|root,COG2403@2|Bacteria,1MV4C@1224|Proteobacteria	1224|Proteobacteria	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_814622_1	679197.HMPREF9336_01924	4.55e-58	183.0	COG0824@1|root,COG0824@2|Bacteria,2IJV6@201174|Actinobacteria	201174|Actinobacteria	S	Thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
k59_814622_2	1449357.JQLK01000005_gene2419	6.62e-08	53.1	COG1062@1|root,COG1062@2|Bacteria,1WKA5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_1174045_1	298655.KI912266_gene1775	7.33e-48	166.0	COG4603@1|root,COG4603@2|Bacteria,2GKAZ@201174|Actinobacteria,4EU1I@85013|Frankiales	201174|Actinobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_814635_2	743718.Isova_0300	4.17e-136	391.0	COG0708@1|root,COG0708@2|Bacteria,2GKEW@201174|Actinobacteria,4F4AI@85017|Promicromonosporaceae	201174|Actinobacteria	L	Endonuclease/Exonuclease/phosphatase family	xthA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_814635_3	269800.Tfu_0200	1.58e-51	182.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4EGHS@85012|Streptosporangiales	201174|Actinobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1174067_1	570268.ANBB01000004_gene135	1.86e-82	257.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4EMXE@85012|Streptosporangiales	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
k59_1174076_1	1255043.TVNIR_3018	4.19e-78	242.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,1WXPV@135613|Chromatiales	135613|Chromatiales	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	cyoE	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_814666_2	1232410.KI421425_gene1548	2.62e-88	266.0	COG0457@1|root,COG0457@2|Bacteria,1N1J2@1224|Proteobacteria,42ZHG@68525|delta/epsilon subdivisions,2WV2W@28221|Deltaproteobacteria,43UR6@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1819185_1	1122939.ATUD01000005_gene2599	8.51e-34	130.0	COG0173@1|root,COG0173@2|Bacteria,2GJHU@201174|Actinobacteria,4CPG8@84995|Rubrobacteria	84995|Rubrobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_814800_1	983917.RGE_35750	7.75e-80	248.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2VK03@28216|Betaproteobacteria,1KJYT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	TIGRFAM hydrogenase (NiFe) small subunit (hydA)	hoxK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
k59_814800_2	1123355.JHYO01000002_gene1258	4.39e-05	44.7	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2TSH1@28211|Alphaproteobacteria,36X2D@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Nickel-dependent hydrogenase	hupL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_1819290_1	572477.Alvin_1388	8.09e-20	86.3	28I2K@1|root,2Z86N@2|Bacteria,1R1GA@1224|Proteobacteria,1RRPU@1236|Gammaproteobacteria,1WXHU@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1819290_2	1121447.JONL01000002_gene1829	9.48e-12	67.4	COG0539@1|root,COG0539@2|Bacteria,1N2EJ@1224|Proteobacteria,42NXS@68525|delta/epsilon subdivisions,2WJ0A@28221|Deltaproteobacteria,2M8S3@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	PFAM RNA binding S1 domain protein	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_1819302_1	300852.55772644	1.2e-43	153.0	COG1250@1|root,COG1250@2|Bacteria,1WIN8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_814844_1	1249627.D779_1529	6.23e-24	96.3	COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,1S3QT@1236|Gammaproteobacteria,1WXYR@135613|Chromatiales	135613|Chromatiales	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
k59_1819331_1	326297.Sama_0227	4.64e-41	138.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,1S452@1236|Gammaproteobacteria,2QBN5@267890|Shewanellaceae	1236|Gammaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010608,GO:0015935,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031329,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043487,GO:0043488,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903311,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
k59_1819331_2	118797.XP_007457196.1	5.86e-39	139.0	COG0096@1|root,COG0097@1|root,KOG1754@2759|Eukaryota,KOG3254@2759|Eukaryota,39WCS@33154|Opisthokonta	33154|Opisthokonta	J	rRNA binding	MRPL6	GO:0000313,GO:0000315,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005762,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0031974,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0097159,GO:0098798,GO:0140053,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_1819393_1	1267535.KB906767_gene666	3.56e-45	154.0	28NPC@1|root,2ZBPA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1819427_1	519989.ECTPHS_10641	1.98e-49	174.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria,1WW4S@135613|Chromatiales	135613|Chromatiales	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_814981_1	768671.ThimaDRAFT_1280	1.96e-93	281.0	COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,1RR31@1236|Gammaproteobacteria,1WXBJ@135613|Chromatiales	135613|Chromatiales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1819492_2	1385517.N800_04155	3.75e-21	88.2	COG0590@1|root,COG0590@2|Bacteria,1N2FE@1224|Proteobacteria,1S35R@1236|Gammaproteobacteria,1X5NY@135614|Xanthomonadales	135614|Xanthomonadales	FJ	Cytidine and deoxycytidylate deaminase zinc-binding region	-	-	-	-	-	-	-	-	-	-	-	-	dCMP_cyt_deam_1
k59_1819533_1	930169.B5T_02691	6.79e-05	47.8	COG3386@1|root,COG3386@2|Bacteria,1MX7V@1224|Proteobacteria,1RMQK@1236|Gammaproteobacteria,1XJKP@135619|Oceanospirillales	135619|Oceanospirillales	G	Gluconolactonase	-	-	-	-	-	-	-	-	-	-	-	-	Str_synth
k59_1819551_1	880072.Desac_2166	3.74e-85	271.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,42MXV@68525|delta/epsilon subdivisions,2WIIT@28221|Deltaproteobacteria,2MRG4@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N,Transketolase_C
k59_881660_1	1043493.BBLU01000014_gene1230	1.15e-21	100.0	COG2339@1|root,COG2339@2|Bacteria,2GKR5@201174|Actinobacteria	201174|Actinobacteria	NU	membrane	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
k59_176683_1	1283283.ATXA01000004_gene4345	1.51e-57	190.0	COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria,4ESAJ@85013|Frankiales	201174|Actinobacteria	GM	PFAM ABC transporter related	rfbB2	-	3.6.3.40	ko:K01990,ko:K09691,ko:K09693	ko02010,map02010	M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.103,3.A.1.104	-	-	ABC_tran,Wzt_C
k59_176683_2	446466.Cfla_2371	4.39e-14	72.0	COG1682@1|root,COG1682@2|Bacteria,2GP5K@201174|Actinobacteria,4F2NK@85016|Cellulomonadaceae	201174|Actinobacteria	GM	ABC-2 type transporter	wzm	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_587595_1	1198232.CYCME_0531	5.09e-26	109.0	COG2433@1|root,COG2433@2|Bacteria,1R1QS@1224|Proteobacteria,1T58I@1236|Gammaproteobacteria,463VZ@72273|Thiotrichales	72273|Thiotrichales	S	Domain of unknown function (DUF4124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124
k59_587595_2	472759.Nhal_3799	7.57e-128	369.0	COG0730@1|root,COG0730@2|Bacteria,1R712@1224|Proteobacteria,1S6UI@1236|Gammaproteobacteria,1WXAK@135613|Chromatiales	135613|Chromatiales	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_411462_1	384765.SIAM614_22462	2.45e-107	320.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria	1224|Proteobacteria	L	Transposase	ISPlu13C	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1703006_1	366602.Caul_1471	4.03e-71	221.0	COG0625@1|root,COG0625@2|Bacteria,1MY47@1224|Proteobacteria,2VEYT@28211|Alphaproteobacteria,2KIIE@204458|Caulobacterales	204458|Caulobacterales	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_3,GST_N
k59_881675_1	367299.JOEE01000001_gene1702	1.54e-52	174.0	COG0454@1|root,COG0456@2|Bacteria,2HX7T@201174|Actinobacteria,4FFK4@85021|Intrasporangiaceae	201174|Actinobacteria	K	N-acetyltransferase GCN5	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_881675_2	1380356.JNIK01000018_gene845	9.38e-07	52.0	COG5401@1|root,COG5401@2|Bacteria,2IMZD@201174|Actinobacteria,4EW2W@85013|Frankiales	201174|Actinobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	AMIN
k59_59767_1	1121904.ARBP01000006_gene4035	1.07e-25	110.0	COG2208@1|root,COG3292@1|root,COG2208@2|Bacteria,COG3292@2|Bacteria,4NHSC@976|Bacteroidetes,47XEJ@768503|Cytophagia	976|Bacteroidetes	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3,Reg_prop,SpoIIE,Y_Y_Y
k59_59771_1	1198232.CYCME_0392	5.82e-63	203.0	COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,1RNZF@1236|Gammaproteobacteria,4613M@72273|Thiotrichales	72273|Thiotrichales	S	Sodium Bile acid symporter family	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
k59_881686_1	391589.RGAI101_110	4.38e-38	140.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TR2Z@28211|Alphaproteobacteria,2P1SI@2433|Roseobacter	28211|Alphaproteobacteria	C	COG0277 FAD FMN-containing dehydrogenases	dld	GO:0003674,GO:0003824,GO:0004457,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008720,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046034,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.1.1.303,1.1.1.4,1.1.2.4	ko:K00004,ko:K00102	ko00620,ko00650,map00620,map00650	-	R00197,R02855,R02946,R10504	RC00044,RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_763756_1	522306.CAP2UW1_0200	7.17e-26	103.0	COG3900@1|root,COG3900@2|Bacteria,1NXBA@1224|Proteobacteria,2WEYS@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
k59_353306_1	879212.DespoDRAFT_00401	5.38e-05	44.7	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,42MRJ@68525|delta/epsilon subdivisions,2WITA@28221|Deltaproteobacteria,2MISV@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
k59_353306_2	1121405.dsmv_1911	3.46e-42	146.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42M3T@68525|delta/epsilon subdivisions,2WIV8@28221|Deltaproteobacteria,2MIMG@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein, alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
k59_881715_1	981369.JQMJ01000004_gene2507	1.78e-104	317.0	COG0536@1|root,COG0536@2|Bacteria,2GISB@201174|Actinobacteria,2NHP0@228398|Streptacidiphilus	201174|Actinobacteria	S	GTP1/OBG	obg	GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
k59_1174713_1	314345.SPV1_08451	4.07e-77	238.0	COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator	yiaJ	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
k59_528907_2	706587.Desti_2888	5.38e-48	160.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42N2W@68525|delta/epsilon subdivisions,2WJRB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_881729_1	298655.KI912266_gene5918	8.63e-45	156.0	COG2084@1|root,COG2084@2|Bacteria,2I9EJ@201174|Actinobacteria	201174|Actinobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_848_1	472759.Nhal_1048	4.28e-95	303.0	COG1067@1|root,COG3638@1|root,COG1067@2|Bacteria,COG3638@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1WXPW@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
k59_235523_1	266117.Rxyl_1929	2.39e-149	448.0	COG1067@1|root,COG1067@2|Bacteria,2H2TE@201174|Actinobacteria	201174|Actinobacteria	O	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
k59_353337_1	999141.GME_02350	4.29e-54	182.0	COG1215@1|root,COG1215@2|Bacteria,1MWH9@1224|Proteobacteria,1RPTN@1236|Gammaproteobacteria,1XHKE@135619|Oceanospirillales	135619|Oceanospirillales	M	Glycosyl transferase	-	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	-
k59_1233438_1	1182590.BN5_03739	8.83e-98	304.0	COG2826@1|root,COG3385@1|root,COG2826@2|Bacteria,COG3385@2|Bacteria,1PQZT@1224|Proteobacteria,1TBQQ@1236|Gammaproteobacteria,1YIJZ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1292610_1	1122194.AUHU01000004_gene1388	1.38e-144	422.0	COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,464NU@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG2951 Membrane-bound lytic murein transglycosylase B	-	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	PG_binding_1,SLT_2
k59_118049_1	207954.MED92_12791	3.77e-142	419.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1XIG9@135619|Oceanospirillales	135619|Oceanospirillales	P	phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_1526842_1	439235.Dalk_0681	1.27e-40	149.0	COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria,2MIRV@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit	-	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
k59_1526842_2	96561.Dole_3185	6.6e-69	226.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MHKH@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
k59_822569_1	1249634.D781_0759	1.44e-71	228.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,402BC@613|Serratia	1236|Gammaproteobacteria	E	Cys Met metabolism	mdeA	-	2.5.1.48,4.4.1.11	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1174736_1	335543.Sfum_3462	4.29e-49	161.0	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,42TRZ@68525|delta/epsilon subdivisions,2WQRI@28221|Deltaproteobacteria,2MQNJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	transcription regulator activity	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
k59_1761727_2	1198232.CYCME_0174	6.99e-22	94.4	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,4602G@72273|Thiotrichales	72273|Thiotrichales	M	mechanosensitive ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel,TM_helix
k59_763806_2	349124.Hhal_1985	6.73e-103	308.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,1WX2E@135613|Chromatiales	135613|Chromatiales	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K00795,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_1703071_1	398767.Glov_2104	0.000125	44.3	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,42QQ4@68525|delta/epsilon subdivisions,2WQGH@28221|Deltaproteobacteria,43UAM@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_1703071_2	278963.ATWD01000001_gene2149	3.67e-28	109.0	COG0741@1|root,COG0741@2|Bacteria,3Y4SM@57723|Acidobacteria,2JJJQ@204432|Acidobacteriia	204432|Acidobacteriia	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
k59_646433_1	384765.SIAM614_28077	1.24e-09	57.8	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TS46@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	dctP	-	-	ko:K11688	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
k59_646433_2	991905.SL003B_0763	7.06e-102	300.0	COG3090@1|root,COG3090@2|Bacteria,1R3YK@1224|Proteobacteria,2TU4N@28211|Alphaproteobacteria,4BQYT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	dctQ	-	-	ko:K11689	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
k59_646433_3	1231190.NA8A_09933	2.56e-130	386.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,43N18@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	dctM	GO:0005575,GO:0016020,GO:0016021,GO:0031224,GO:0044425	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM,DctQ
k59_1116055_1	557598.LHK_02324	2.55e-87	275.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2VHXG@28216|Betaproteobacteria,2KPGU@206351|Neisseriales	206351|Neisseriales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_896_1	1043493.BBLU01000001_gene867	3.78e-154	443.0	COG2942@1|root,COG2942@2|Bacteria,2GMJ7@201174|Actinobacteria	201174|Actinobacteria	G	N-acylglucosamine 2-epimerase	-	-	-	-	-	-	-	-	-	-	-	-	GlcNAc_2-epim
k59_176758_1	296591.Bpro_5346	2.21e-175	516.0	COG3677@1|root,COG3677@2|Bacteria,1R3VM@1224|Proteobacteria,2W1BX@28216|Betaproteobacteria	28216|Betaproteobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_59918_1	713586.KB900536_gene1684	2.88e-140	414.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1WVWH@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_1174760_1	1120919.AUBI01000004_gene1919	5.94e-29	105.0	COG1670@1|root,COG1670@2|Bacteria,1MVG4@1224|Proteobacteria,2TUIK@28211|Alphaproteobacteria,2JRYR@204441|Rhodospirillales	204441|Rhodospirillales	J	Acetyltransferase (GNAT) domain	rimJ	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
k59_1174760_3	1121878.AUGL01000009_gene3305	1.31e-64	199.0	COG3791@1|root,COG3791@2|Bacteria,1PSHH@1224|Proteobacteria,1SB5F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_940532_1	1122603.ATVI01000007_gene1638	2.33e-34	124.0	COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,1S2AY@1236|Gammaproteobacteria,1X7VV@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine phosphatase superfamily (branch 1)	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
k59_940532_2	313628.LNTAR_23729	1.94e-16	79.3	COG3568@1|root,COG3568@2|Bacteria	2|Bacteria	N	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_1292708_2	380358.XALC_0317	1.46e-29	109.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,1SCFM@1236|Gammaproteobacteria,1X7GP@135614|Xanthomonadales	135614|Xanthomonadales	P	protein involved in tolerance to divalent cations	cutA	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
k59_176759_1	1158165.KB898871_gene2345	1.48e-31	121.0	COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria,1WWAM@135613|Chromatiales	135613|Chromatiales	H	Uroporphyrinogen III synthase	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
k59_176759_2	396588.Tgr7_0025	2.25e-161	461.0	COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1MV72@1224|Proteobacteria,1RPH5@1236|Gammaproteobacteria,1WXHI@135613|Chromatiales	135613|Chromatiales	C	Oxidoreductase FAD-binding domain	-	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
k59_176759_3	713586.KB900536_gene2161	7.4e-76	240.0	COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1RNDT@1236|Gammaproteobacteria,1WW02@135613|Chromatiales	135613|Chromatiales	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10,RmlD_sub_bind
k59_1585625_1	977880.RALTA_A1392	2.03e-82	266.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VIAU@28216|Betaproteobacteria,1K10Y@119060|Burkholderiaceae	28216|Betaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1057462_1	1120956.JHZK01000042_gene3046	2.89e-102	314.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2015, Alkyl sulfatase and related hydrolases	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_1829795_2	1122182.KB903833_gene5631	5.31e-25	96.7	COG0261@1|root,COG0261@2|Bacteria,2IQ9A@201174|Actinobacteria,4DE6G@85008|Micromonosporales	201174|Actinobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
k59_10372_1	335543.Sfum_2948	7.16e-105	316.0	COG2848@1|root,COG2848@2|Bacteria,1NAFG@1224|Proteobacteria,42NH7@68525|delta/epsilon subdivisions,2WJJM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	UPF0210 protein	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
k59_1240448_1	316274.Haur_0057	3.09e-43	153.0	COG1397@1|root,COG1397@2|Bacteria,2G7F9@200795|Chloroflexi,375E9@32061|Chloroflexia	32061|Chloroflexia	O	PFAM ADP-ribosylation Crystallin J1	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
k59_362232_1	765910.MARPU_02750	1.57e-107	320.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1WWQ1@135613|Chromatiales	135613|Chromatiales	H	Belongs to the ribF family	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
k59_68763_1	1335757.SPICUR_01785	3.97e-40	148.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1WXQX@135613|Chromatiales	135613|Chromatiales	L	DNA photolyase	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_1829798_1	1168289.AJKI01000016_gene1954	2.8e-55	193.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FMCU@200643|Bacteroidia,3XKI3@558415|Marinilabiliaceae	976|Bacteroidetes	G	Glycosyl hydrolase family 3 C-terminal domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_1829798_2	1122176.KB903553_gene3640	1.29e-05	46.6	COG0477@1|root,COG2814@2|Bacteria,4NE09@976|Bacteroidetes,1IP67@117747|Sphingobacteriia	976|Bacteroidetes	EGP	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
k59_593768_1	1267005.KB911255_gene2578	5.14e-66	214.0	COG0683@1|root,COG0683@2|Bacteria,1QURG@1224|Proteobacteria,2TS62@28211|Alphaproteobacteria,3N717@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	LppC putative lipoprotein	MA20_24635	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_300349_1	344747.PM8797T_10469	4.16e-185	525.0	COG1234@1|root,COG1234@2|Bacteria,2J27A@203682|Planctomycetes	203682|Planctomycetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1003810_1	768671.ThimaDRAFT_2737	5.61e-50	178.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales	135613|Chromatiales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_244175_1	158189.SpiBuddy_2362	1.37e-07	55.1	COG4227@1|root,COG4227@2|Bacteria	2|Bacteria	L	nucleotidyltransferase activity	traC	-	-	-	-	-	-	-	-	-	-	-	DUF1738
k59_711247_1	706587.Desti_1077	1.41e-14	73.9	COG0861@1|root,COG0861@2|Bacteria,1QZU6@1224|Proteobacteria,42S1Q@68525|delta/epsilon subdivisions,2WNNS@28221|Deltaproteobacteria,2MQEU@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM Integral membrane protein TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
k59_711247_2	876269.ARWA01000001_gene1773	1.47e-09	59.3	COG0861@1|root,COG0861@2|Bacteria,1QZU6@1224|Proteobacteria,2TURK@28211|Alphaproteobacteria,3NB6X@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Integral membrane protein TerC family	-	-	-	-	-	-	-	-	-	-	-	-	TerC
k59_1650763_2	395493.BegalDRAFT_3262	1.2e-49	163.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,460EK@72273|Thiotrichales	72273|Thiotrichales	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_1767385_2	439235.Dalk_3237	1.61e-56	192.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,42MRJ@68525|delta/epsilon subdivisions,2WITA@28221|Deltaproteobacteria,2MISV@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
k59_124234_1	1193181.BN10_1700015	1.73e-122	355.0	COG2801@1|root,COG2801@2|Bacteria,2GKDY@201174|Actinobacteria,4FEXK@85021|Intrasporangiaceae	201174|Actinobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_124234_2	1193181.BN10_1700014	1.85e-08	52.0	COG2963@1|root,COG2963@2|Bacteria,2ISHZ@201174|Actinobacteria	201174|Actinobacteria	L	PFAM transposase IS3 IS911 family protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_652602_1	40571.JOEA01000004_gene6317	7.91e-59	206.0	COG4249@1|root,COG4249@2|Bacteria,2IAM3@201174|Actinobacteria,4E3RZ@85010|Pseudonocardiales	201174|Actinobacteria	O	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,WD40
k59_1829818_1	446466.Cfla_1934	2.54e-100	312.0	COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria,4F0S9@85016|Cellulomonadaceae	201174|Actinobacteria	G	Belongs to the transketolase family	tkt	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_10403_1	335543.Sfum_3923	2.77e-83	267.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,2MRI6@213462|Syntrophobacterales	28221|Deltaproteobacteria	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1532789_1	649638.Trad_0271	1.52e-23	103.0	COG2202@1|root,COG4585@1|root,COG2202@2|Bacteria,COG4585@2|Bacteria,1WMUT@1297|Deinococcus-Thermus	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	mcpA	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HATPase_c,HisKA_3,MCPsignal,PAS_3,PAS_4,PAS_9
k59_1591248_1	367299.JOEE01000006_gene807	1.96e-25	103.0	COG0160@1|root,COG0160@2|Bacteria,2GIS9@201174|Actinobacteria,4FFF5@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	-	2.6.1.19,2.6.1.22	ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1591248_2	367299.JOEE01000006_gene808	1.74e-52	174.0	COG1028@1|root,COG1028@2|Bacteria,2GKW9@201174|Actinobacteria,4FIQI@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1532794_1	1415780.JPOG01000001_gene1377	2.88e-60	204.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1X3EZ@135614|Xanthomonadales	135614|Xanthomonadales	L	Single-stranded-DNA-specific exonuclease	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_244213_1	85643.Tmz1t_1788	1.27e-24	97.4	COG1845@1|root,COG1845@2|Bacteria,1RDNK@1224|Proteobacteria,2VKAY@28216|Betaproteobacteria,2KVB4@206389|Rhodocyclales	206389|Rhodocyclales	C	Heme copper-type cytochrome quinol oxidase, subunit 3	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_244213_2	1163617.SCD_n00913	3.03e-22	89.7	2DQ8G@1|root,3359N@2|Bacteria,1N7W4@1224|Proteobacteria,2VXI1@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1591249_1	96561.Dole_1354	5.29e-53	174.0	2C5J8@1|root,30F9Z@2|Bacteria,1RE16@1224|Proteobacteria,42RYB@68525|delta/epsilon subdivisions,2WNIF@28221|Deltaproteobacteria,2MJSR@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1240486_1	1452718.JBOY01000024_gene350	4.55e-68	231.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_828445_2	485914.Hmuk_2358	0.000262	45.4	COG0516@1|root,arCOG00612@2157|Archaea,2XU40@28890|Euryarchaeota,23TNA@183963|Halobacteria	183963|Halobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
k59_1767402_1	1157708.KB907455_gene3154	8.75e-24	100.0	COG0304@1|root,COG0304@2|Bacteria,1N91E@1224|Proteobacteria,2VJR3@28216|Betaproteobacteria,4ACEW@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabB	-	2.3.1.179,2.3.1.41	ko:K00647,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_1767402_2	383407.XOC_0422	1.03e-33	119.0	COG0236@1|root,COG0236@2|Bacteria,1N6RU@1224|Proteobacteria,1SCW1@1236|Gammaproteobacteria,1X7FB@135614|Xanthomonadales	135614|Xanthomonadales	IQ	acyl carrier protein	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
k59_1767402_3	62928.azo3921	6.96e-18	82.4	COG0644@1|root,COG0644@2|Bacteria,1MZVI@1224|Proteobacteria,2VH6J@28216|Betaproteobacteria,2KV83@206389|Rhodocyclales	206389|Rhodocyclales	C	Tryptophan halogenase	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
k59_244223_1	670307.HYPDE_36098	8.25e-96	285.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TSQF@28211|Alphaproteobacteria,3N7ZT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Two component transcriptional regulator	petR	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_10434_1	257313.BP1263	2.42e-48	157.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2VSHX@28216|Betaproteobacteria,3T488@506|Alcaligenaceae	28216|Betaproteobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_890535_1	221288.JH992901_gene1078	6.06e-118	356.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1FZX5@1117|Cyanobacteria,1JHD5@1189|Stigonemataceae	1117|Cyanobacteria	KOT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Response_reg
k59_890535_2	251221.35212227	5.82e-91	288.0	COG0664@1|root,COG3852@1|root,COG0664@2|Bacteria,COG3852@2|Bacteria,1GQDB@1117|Cyanobacteria	1117|Cyanobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,cNMP_binding
k59_1180972_1	933262.AXAM01000040_gene1210	3.08e-59	196.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,42MBN@68525|delta/epsilon subdivisions,2WINT@28221|Deltaproteobacteria,2MIZ6@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
k59_10447_1	1168034.FH5T_04505	3.54e-105	317.0	COG0502@1|root,COG0502@2|Bacteria,4NEI7@976|Bacteroidetes,2FM8N@200643|Bacteroidia	976|Bacteroidetes	C	In Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and IscS	hydG	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
k59_362289_1	765912.Thimo_0460	6.41e-66	217.0	COG2863@1|root,COG3258@1|root,COG2863@2|Bacteria,COG3258@2|Bacteria,1NIQK@1224|Proteobacteria,1RZH1@1236|Gammaproteobacteria,1WXQK@135613|Chromatiales	135613|Chromatiales	C	PFAM Cytochrome C	-	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0016667,GO:0016669,GO:0022900,GO:0042597,GO:0044237,GO:0044464,GO:0050338,GO:0055114	1.8.2.2	ko:K19713	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_182980_1	1123518.ARWI01000001_gene400	1.13e-136	414.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_124264_1	1184607.AUCHE_08_01400	7.45e-45	164.0	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria	201174|Actinobacteria	G	alpha amylase, catalytic	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_417491_1	1123392.AQWL01000009_gene1117	2.91e-67	221.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2VHJ5@28216|Betaproteobacteria,1KS3F@119069|Hydrogenophilales	119069|Hydrogenophilales	C	FAD binding domain	-	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
k59_417491_2	765911.Thivi_3300	4.15e-101	293.0	COG1146@1|root,COG1146@2|Bacteria,1RC9N@1224|Proteobacteria,1S3TG@1236|Gammaproteobacteria,1X27P@135613|Chromatiales	135613|Chromatiales	C	Adenosine-5'-phosphosulfate reductase beta subunit	-	-	1.8.99.2	ko:K00395	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	APS-reductase_C,Fer4_9
k59_476388_1	522306.CAP2UW1_0062	1.51e-82	258.0	COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,2WGS2@28216|Betaproteobacteria,1KR4T@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1829857_2	1294143.H681_09870	6.83e-166	476.0	COG4487@1|root,COG4487@2|Bacteria,1MWNT@1224|Proteobacteria,1S2QE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2130)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2130
k59_1301704_1	1123256.KB907925_gene1205	1.93e-67	213.0	COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1X4H8@135614|Xanthomonadales	135614|Xanthomonadales	NU	Pilus assembly protein, PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
k59_828461_1	1111732.AZOD01000005_gene874	8e-15	74.7	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1X3IV@135614|Xanthomonadales	135614|Xanthomonadales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_828461_2	765912.Thimo_3116	4.48e-73	236.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,1WX75@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_10473_1	717785.HYPMC_0031	1.28e-50	172.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TTMF@28211|Alphaproteobacteria,3N64T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739,ko:K10764	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_949520_1	1304865.JAGF01000001_gene1531	1.24e-20	90.5	COG1477@1|root,COG1477@2|Bacteria	2|Bacteria	H	protein flavinylation	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_1708987_1	1219072.VHA01S_047_00040	3.05e-28	115.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,1XSD5@135623|Vibrionales	1236|Gammaproteobacteria	P	Arylsulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_1708987_2	1449347.JQLN01000005_gene3942	8.63e-06	47.4	COG4803@1|root,COG4803@2|Bacteria,2IHYU@201174|Actinobacteria,2M2QH@2063|Kitasatospora	201174|Actinobacteria	S	Protein of unknown function (DUF1269)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
k59_10478_1	983917.RGE_24270	2.87e-37	137.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2VJZP@28216|Betaproteobacteria,1KJ83@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	peptidylprolyl isomerase	cbf2	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N_3
k59_1003853_1	396588.Tgr7_0634	1.66e-09	58.2	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,1WWRW@135613|Chromatiales	135613|Chromatiales	C	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
k59_1003853_2	743720.Psefu_2864	4.15e-09	53.9	COG4736@1|root,COG4736@2|Bacteria,1QNMB@1224|Proteobacteria,1TM7I@1236|Gammaproteobacteria,1YZ6U@136845|Pseudomonas putida group	1236|Gammaproteobacteria	O	cytochrome oxidase	-	-	-	ko:K00407	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixQ
k59_1181447_2	2340.JV46_13030	2.06e-54	179.0	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,1S7ID@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_1357285_1	296591.Bpro_4776	2.89e-67	208.0	2BVFD@1|root,32QUS@2|Bacteria,1RHF0@1224|Proteobacteria,2VT3V@28216|Betaproteobacteria,4AHPM@80864|Comamonadaceae	28216|Betaproteobacteria	S	Electron transfer DM13	-	-	-	-	-	-	-	-	-	-	-	-	DM13
k59_1357285_2	565045.NOR51B_1907	2.14e-87	276.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,1RMCN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0659 Sulfate permease and related transporters (MFS superfamily)	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_69374_1	1026882.MAMP_00222	5.14e-12	65.5	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,46034@72273|Thiotrichales	72273|Thiotrichales	U	TIGRFAM type IV pilus secretin (or competence protein) PilQ	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_891098_1	446466.Cfla_1596	7.24e-84	274.0	COG0707@1|root,COG0773@1|root,COG0707@2|Bacteria,COG0773@2|Bacteria,2GJEM@201174|Actinobacteria,4F33R@85016|Cellulomonadaceae	201174|Actinobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227,6.3.2.8	ko:K01924,ko:K02563	ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112	-	R03193,R05032,R05662	RC00005,RC00049,RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_1065264_1	999541.bgla_2g20450	6.56e-61	203.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,2VII8@28216|Betaproteobacteria,1KH3H@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor	otsA	-	2.4.1.15,2.4.1.213,2.4.1.347	ko:K00697,ko:K03692	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
k59_1065264_2	570967.JMLV01000013_gene3393	3.58e-52	180.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,2TRMQ@28211|Alphaproteobacteria,2JQKZ@204441|Rhodospirillales	204441|Rhodospirillales	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
k59_1302248_1	1464048.JNZS01000008_gene6248	6.62e-09	59.3	COG1070@1|root,COG1070@2|Bacteria,2GNCR@201174|Actinobacteria,4DER4@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the FGGY kinase family	-	-	2.7.1.12,2.7.1.17	ko:K00851,ko:K00854	ko00030,ko00040,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00040,map01100,map01110,map01120,map01130,map01200	M00014	R01639,R01737	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
k59_1709366_1	1278309.KB907101_gene404	2.7e-12	65.5	COG1180@1|root,COG1180@2|Bacteria,1RA4Z@1224|Proteobacteria,1S34Q@1236|Gammaproteobacteria,1XRSI@135619|Oceanospirillales	135619|Oceanospirillales	O	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
k59_1709366_2	1123399.AQVE01000004_gene2512	3.99e-54	179.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,460H9@72273|Thiotrichales	72273|Thiotrichales	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	cyoE	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_300788_1	290398.Csal_1227	1.09e-21	94.7	2E3D3@1|root,32YCC@2|Bacteria,1NAK2@1224|Proteobacteria,1SED0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Chalcone isomerase-like	-	-	-	-	-	-	-	-	-	-	-	-	Chalcone_3
k59_300788_2	631362.Thi970DRAFT_00034	2.55e-15	72.4	COG3011@1|root,COG3011@2|Bacteria,1PV30@1224|Proteobacteria,1SCCX@1236|Gammaproteobacteria,1WZJ7@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function, DUF393	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
k59_11293_1	395494.Galf_2592	1.75e-83	261.0	COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,2VJX1@28216|Betaproteobacteria,44VIP@713636|Nitrosomonadales	28216|Betaproteobacteria	H	UbiA prenyltransferase family	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_1476099_1	1121405.dsmv_0557	9.23e-40	149.0	COG0427@1|root,COG0454@1|root,COG0427@2|Bacteria,COG0456@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MJ4K@213118|Desulfobacterales	28221|Deltaproteobacteria	CK	PFAM Acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
k59_653055_1	1123065.ATWL01000011_gene35	1.86e-116	339.0	COG0179@1|root,COG0179@2|Bacteria,2GN2G@201174|Actinobacteria	201174|Actinobacteria	Q	2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase	fahA	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
k59_653055_2	471853.Bcav_1561	5.37e-119	348.0	COG0500@1|root,COG2226@2|Bacteria,2GK7A@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
k59_1533239_2	1499967.BAYZ01000073_gene2011	1.54e-15	72.8	COG1610@1|root,COG1610@2|Bacteria,2NPQ9@2323|unclassified Bacteria	2|Bacteria	S	Yqey-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
k59_124712_1	756272.Plabr_3405	1.46e-20	90.1	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_16,GerE,Response_reg
k59_69389_1	323261.Noc_2021	7.55e-123	381.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales	135613|Chromatiales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,Response_reg
k59_1181473_1	933262.AXAM01000020_gene22	9.39e-20	83.2	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,42V1U@68525|delta/epsilon subdivisions,2WR76@28221|Deltaproteobacteria,2MKCK@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Preprotein translocase subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
k59_1181473_2	335543.Sfum_1239	2.76e-29	117.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2WJCI@28221|Deltaproteobacteria,2MR54@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_653059_1	1304872.JAGC01000003_gene2442	1.34e-21	95.9	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,42N5I@68525|delta/epsilon subdivisions,2WM5T@28221|Deltaproteobacteria,2M9FV@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_535632_2	572477.Alvin_0133	2.02e-132	388.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1WWB9@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_711735_1	1396.DJ87_2818	8.87e-15	81.6	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,1ZBEA@1386|Bacillus	91061|Bacilli	NT	chemotaxis protein	mcpA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
k59_1302273_1	1121374.KB891576_gene355	5.98e-31	134.0	COG1629@1|root,COG1629@2|Bacteria,1QTVF@1224|Proteobacteria,1T3JT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_1186801_1	335543.Sfum_0413	3.99e-80	257.0	COG0457@1|root,COG1944@1|root,COG0457@2|Bacteria,COG1944@2|Bacteria,1MV7K@1224|Proteobacteria,42N4B@68525|delta/epsilon subdivisions,2WJ34@28221|Deltaproteobacteria,2MRDN@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8,YcaO
k59_1008312_1	1249627.D779_2404	1.5e-59	200.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1WWK5@135613|Chromatiales	135613|Chromatiales	O	FeS assembly protein SufD	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_188704_1	864051.BurJ1DRAFT_3331	2.8e-62	192.0	COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,2VSFJ@28216|Betaproteobacteria	28216|Betaproteobacteria	P	DsrC like protein	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_957085_1	883078.HMPREF9695_00853	2.39e-57	186.0	COG1028@1|root,COG1028@2|Bacteria,1MU5Y@1224|Proteobacteria,2TRNQ@28211|Alphaproteobacteria,3JRK8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	1.1.1.30	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	M00088	R01361	RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
k59_254333_1	1384056.N787_09565	5.41e-63	212.0	COG1770@1|root,COG1770@2|Bacteria,1MUED@1224|Proteobacteria,1RMSV@1236|Gammaproteobacteria,1X31I@135614|Xanthomonadales	135614|Xanthomonadales	E	peptidase	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_254333_2	1301098.PKB_0253	1.76e-06	50.4	COG0810@1|root,COG0810@2|Bacteria,1MXBE@1224|Proteobacteria,1RMI4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	tonB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0007154,GO:0007165,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0015688,GO:0015833,GO:0015889,GO:0015891,GO:0015893,GO:0016020,GO:0016021,GO:0016032,GO:0019058,GO:0019062,GO:0019904,GO:0022610,GO:0023052,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0031992,GO:0032991,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0042914,GO:0043213,GO:0044403,GO:0044406,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0044650,GO:0046813,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0051704,GO:0051716,GO:0060089,GO:0065007,GO:0071575,GO:0071702,GO:0071705,GO:0071944,GO:0098002,GO:0098552,GO:0098670,GO:0098796,GO:0098797,GO:1901678	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	iAPECO1_1312.APECO1_368,iEC55989_1330.EC55989_1350,iECABU_c1320.ECABU_c15340,iECNA114_1301.ECNA114_1423,iECO103_1326.ECO103_1353,iECP_1309.ECP_1300,iECSF_1327.ECSF_1233,iEcE24377_1341.EcE24377A_1410	TonB_C,TonB_N
k59_369812_1	439235.Dalk_2776	6.17e-55	183.0	COG0247@1|root,COG1146@1|root,COG0247@2|Bacteria,COG1146@2|Bacteria,1N5Q2@1224|Proteobacteria,42P5D@68525|delta/epsilon subdivisions,2WJ9I@28221|Deltaproteobacteria,2MI9D@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8,Fer4_9
k59_898073_1	247634.GPB2148_2326	6.82e-06	48.1	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000028,GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003723,GO:0003729,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070475,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_773398_1	1304275.C41B8_01320	5.8e-59	194.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_20787_1	324602.Caur_3745	7.53e-169	491.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_77141_1	1122212.AULO01000009_gene753	8.14e-90	273.0	COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,1S2TG@1236|Gammaproteobacteria,1XJCR@135619|Oceanospirillales	135619|Oceanospirillales	S	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_77141_2	1049564.TevJSym_ax00180	2.35e-55	186.0	COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,1RZVF@1236|Gammaproteobacteria,1JBWE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	NlpB/DapX lipoprotein	bamC	-	-	ko:K07287	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	Lipoprotein_18
k59_1187448_1	1123517.JOMR01000001_gene1508	1.16e-11	65.9	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,4602E@72273|Thiotrichales	72273|Thiotrichales	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
k59_1187448_2	1283300.ATXB01000002_gene2824	2.02e-44	152.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,1XE1X@135618|Methylococcales	135618|Methylococcales	EH	PFAM Aminotransferase, class IV	-	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
k59_130720_1	713586.KB900536_gene1092	6.23e-59	197.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1WW9V@135613|Chromatiales	135613|Chromatiales	J	TIGRFAM ribonuclease, Rne Rng family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_130720_2	998674.ATTE01000001_gene2119	4.39e-06	47.8	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,460Q4@72273|Thiotrichales	72273|Thiotrichales	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
k59_21616_1	1123368.AUIS01000010_gene2370	1.14e-39	142.0	COG4798@1|root,COG4798@2|Bacteria,1QUNP@1224|Proteobacteria,1S3N0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_1422413_1	95619.PM1_0221770	4.17e-34	130.0	COG4796@1|root,COG4796@2|Bacteria,1RCNA@1224|Proteobacteria,1SE5I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Type II secretory pathway, component	-	-	-	-	-	-	-	-	-	-	-	-	Secretin,Secretin_N
k59_423638_1	471853.Bcav_2957	9.43e-66	209.0	COG0180@1|root,COG0180@2|Bacteria,2GJ9A@201174|Actinobacteria	201174|Actinobacteria	J	Tryptophanyl-tRNA synthetase	trpS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_834774_1	870187.Thini_2169	6.91e-74	229.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RMVZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Fe-S oxidoreductase	lutA	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
k59_599477_1	1121448.DGI_1873	9.01e-62	209.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1QZPK@1224|Proteobacteria,42NQE@68525|delta/epsilon subdivisions,2WJPH@28221|Deltaproteobacteria,2M8MZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_4,PAS_9,Response_reg
k59_599477_2	1121440.AUMA01000010_gene312	6.62e-51	164.0	COG0745@1|root,COG0745@2|Bacteria,1NBDV@1224|Proteobacteria,42UVC@68525|delta/epsilon subdivisions,2WQ45@28221|Deltaproteobacteria,2MBV0@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_370729_1	1120980.JQKH01000004_gene445	3.75e-38	142.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2VH77@28216|Betaproteobacteria,2KPWC@206351|Neisseriales	206351|Neisseriales	C	L-lactate dehydrogenase	lldD	-	1.1.2.3	ko:K00101	ko00620,ko01100,map00620,map01100	-	R00196	RC00044	ko00000,ko00001,ko01000	-	-	-	FMN_dh
k59_1773217_1	1219072.VHA01S_005_00410	1.12e-72	244.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,1RMVE@1236|Gammaproteobacteria,1Y0BR@135623|Vibrionales	135623|Vibrionales	C	Molydopterin dinucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding
k59_1310152_1	765912.Thimo_1174	4.46e-92	290.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1WW41@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_255225_1	1123242.JH636435_gene1811	1.07e-12	72.8	COG2021@1|root,COG2021@2|Bacteria,2IYHN@203682|Planctomycetes	203682|Planctomycetes	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,MetW
k59_1126430_2	590998.Celf_0545	1.22e-54	193.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2GKI9@201174|Actinobacteria,4F0N4@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8
k59_423658_1	1121927.GOHSU_04_01290	1.14e-12	71.6	COG0775@1|root,COG0775@2|Bacteria,2IMZ7@201174|Actinobacteria,4GE5X@85026|Gordoniaceae	201174|Actinobacteria	F	Phosphorylase superfamily	-	-	3.2.2.1,3.2.2.9	ko:K01239,ko:K01243	ko00230,ko00270,ko00760,ko01100,ko01230,map00230,map00270,map00760,map01100,map01230	M00034,M00609	R00194,R01245,R01273,R01401,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
k59_423658_2	684949.ATTJ01000001_gene2116	1.07e-07	53.5	COG2107@1|root,COG2107@2|Bacteria,1WICQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
k59_773931_1	765912.Thimo_1933	3e-121	368.0	COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,1QTS5@1224|Proteobacteria,1RMJS@1236|Gammaproteobacteria,1WW9Q@135613|Chromatiales	135613|Chromatiales	C	belongs to the CobB CobQ family	-	-	2.3.1.8	ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,DRTGG,PTA_PTB
k59_899016_1	1239962.C943_02877	3.06e-19	89.0	COG3965@1|root,COG3965@2|Bacteria,4NZGM@976|Bacteroidetes,47STU@768503|Cytophagia	976|Bacteroidetes	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
k59_1838377_1	765911.Thivi_1421	3.83e-58	190.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RPM1@1236|Gammaproteobacteria,1WW4Q@135613|Chromatiales	135613|Chromatiales	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_1838377_2	1121459.AQXE01000004_gene1748	2.57e-44	156.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,42PSG@68525|delta/epsilon subdivisions,2WKYN@28221|Deltaproteobacteria,2MB0W@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
k59_541241_1	768671.ThimaDRAFT_4796	4.16e-11	69.3	28P52@1|root,2ZC06@2|Bacteria,1QDPX@1224|Proteobacteria,1S1Z6@1236|Gammaproteobacteria,1WY58@135613|Chromatiales	135613|Chromatiales	S	Type II secretion system protein B	-	-	-	ko:K02451	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	T2SSB
k59_1484275_2	369723.Strop_3411	1.83e-06	50.1	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4DIF7@85008|Micromonosporales	201174|Actinobacteria	J	Amidase	bam	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_1484275_3	1347086.CCBA010000023_gene2347	3.8e-36	141.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,4HAAG@91061|Bacilli,1ZPV2@1386|Bacillus	91061|Bacilli	G	Belongs to the glycosyl hydrolase 3 family	bglB	-	3.2.1.21,3.2.1.52	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	M00628	R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
k59_1773224_2	1150398.JIBJ01000004_gene2753	1.7e-113	332.0	COG0656@1|root,COG0656@2|Bacteria,2GJQ7@201174|Actinobacteria,1WAGZ@1268|Micrococcaceae	201174|Actinobacteria	S	Aldo/keto reductase family	-	-	1.1.1.346	ko:K06221	-	-	R08878	RC00089	ko00000,ko01000	-	-	-	Aldo_ket_red
k59_1538861_1	591158.SSMG_06319	2.06e-106	329.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,2GJ50@201174|Actinobacteria	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_423664_1	880072.Desac_0030	2.14e-11	64.7	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NF6@68525|delta/epsilon subdivisions,2WKVH@28221|Deltaproteobacteria,2MR9V@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_423664_2	880072.Desac_0031	2.18e-76	238.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria,2MRMI@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
k59_189406_1	263358.VAB18032_16965	9.12e-32	117.0	29P1W@1|root,30A02@2|Bacteria,2IE5P@201174|Actinobacteria,4D9GV@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_599498_1	452637.Oter_2665	5.84e-113	340.0	COG0415@1|root,COG0415@2|Bacteria,46TVC@74201|Verrucomicrobia,3K926@414999|Opitutae	414999|Opitutae	H	PFAM DNA photolyase FAD-binding	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
k59_599498_2	292415.Tbd_2635	4.69e-39	139.0	COG0494@1|root,COG0494@2|Bacteria,1MYSK@1224|Proteobacteria,2W3WC@28216|Betaproteobacteria	28216|Betaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_599499_1	717785.HYPMC_0050	2.12e-36	142.0	COG1511@1|root,COG1511@2|Bacteria,1QY7Q@1224|Proteobacteria,2TXIQ@28211|Alphaproteobacteria,3N82W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4175)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4175
k59_1422469_1	593907.Celgi_0898	1.41e-139	413.0	COG1080@1|root,COG1080@2|Bacteria,2GIZZ@201174|Actinobacteria	201174|Actinobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_1126449_1	590998.Celf_3169	1.78e-62	209.0	COG1233@1|root,COG1233@2|Bacteria,2GJAV@201174|Actinobacteria,4F0PG@85016|Cellulomonadaceae	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_370765_1	85643.Tmz1t_2726	1.38e-76	239.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2VHDA@28216|Betaproteobacteria,2KVFY@206389|Rhodocyclales	206389|Rhodocyclales	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
k59_659091_1	471852.Tcur_3850	1.72e-47	161.0	COG1496@1|root,COG1496@2|Bacteria,2GN1M@201174|Actinobacteria,4EFKZ@85012|Streptosporangiales	201174|Actinobacteria	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
k59_306207_1	767434.Fraau_2811	5.84e-86	270.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria,1X31X@135614|Xanthomonadales	135614|Xanthomonadales	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	etf-QO	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8,Thi4
k59_1538885_1	1304865.JAGF01000001_gene3857	1.27e-96	309.0	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4F11C@85016|Cellulomonadaceae	201174|Actinobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_1074377_1	1173027.Mic7113_1750	6.38e-37	135.0	COG1960@1|root,COG1960@2|Bacteria,1G3AS@1117|Cyanobacteria,1H8VI@1150|Oscillatoriales	1117|Cyanobacteria	I	PFAM Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_1074377_2	394503.Ccel_0989	9.2e-45	155.0	COG3882@1|root,COG3882@2|Bacteria,1TTCC@1239|Firmicutes,24A4U@186801|Clostridia,36G4Q@31979|Clostridiaceae	186801|Clostridia	Q	HAD-superfamily phosphatase, subfamily IIIC	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
k59_1484310_1	1038858.AXBA01000028_gene1036	3.96e-14	72.0	COG0591@1|root,COG0642@1|root,COG0784@1|root,COG0591@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,3EYE9@335928|Xanthobacteraceae	28211|Alphaproteobacteria	T	histidine kinase A domain protein	MA20_19630	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
k59_1484310_2	935261.JAGL01000024_gene28	4.53e-22	89.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2U99Y@28211|Alphaproteobacteria,43JWJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
k59_255271_1	335283.Neut_2269	7.56e-27	110.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,373XP@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_255271_2	251221.35211633	3.83e-27	106.0	COG5622@1|root,COG5622@2|Bacteria,1G656@1117|Cyanobacteria	1117|Cyanobacteria	N	Protein required for attachment to host cells	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach
k59_1310211_1	653733.Selin_0359	1.87e-17	81.3	COG0202@1|root,COG0202@2|Bacteria	2|Bacteria	K	RNA polymerase activity	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_1310211_2	1219626.HMPREF1639_01870	4.86e-15	74.3	COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,25RBB@186804|Peptostreptococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_77244_1	991905.SL003B_3362	3.3e-16	75.5	COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,2UFJJ@28211|Alphaproteobacteria,4BR0U@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex	atpI	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
k59_77244_2	991905.SL003B_3361	4.64e-13	68.2	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2TRNV@28211|Alphaproteobacteria,4BPYN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_1714794_2	1123228.AUIH01000011_gene2055	1.22e-64	200.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria,1XJKR@135619|Oceanospirillales	135619|Oceanospirillales	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
k59_1838434_1	367299.JOEE01000008_gene566	3.86e-79	259.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,2GJ11@201174|Actinobacteria,4FF6T@85021|Intrasporangiaceae	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
k59_1362913_1	1449069.JMLO01000022_gene3133	1.15e-38	143.0	COG4325@1|root,COG4325@2|Bacteria,2GWFP@201174|Actinobacteria,4FYAN@85025|Nocardiaceae	201174|Actinobacteria	S	Predicted membrane protein (DUF2254)	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009405,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0051704	-	-	-	-	-	-	-	-	-	-	DUF2254
k59_423702_1	880072.Desac_1893	4.96e-57	191.0	COG1418@1|root,COG1418@2|Bacteria,1P7YA@1224|Proteobacteria,42KZ8@68525|delta/epsilon subdivisions,2WJG1@28221|Deltaproteobacteria,2MQ65@213462|Syntrophobacterales	28221|Deltaproteobacteria	A	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
k59_423702_2	880072.Desac_1892	2.96e-36	129.0	COG1692@1|root,COG1692@2|Bacteria,1MW12@1224|Proteobacteria,42PCG@68525|delta/epsilon subdivisions,2WM8X@28221|Deltaproteobacteria,2MR9H@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
k59_1008917_1	929704.Myrod_1698	1.18e-12	68.9	COG0008@1|root,COG0008@2|Bacteria,4NEED@976|Bacteroidetes,1HXQH@117743|Flavobacteriia,47GVA@76831|Myroides	976|Bacteroidetes	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_1008917_2	998674.ATTE01000001_gene3594	7.01e-42	141.0	COG2346@1|root,COG2346@2|Bacteria,1RH21@1224|Proteobacteria,1S4I5@1236|Gammaproteobacteria,462ZB@72273|Thiotrichales	72273|Thiotrichales	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
k59_1310233_2	1254432.SCE1572_36760	1.54e-32	119.0	COG1278@1|root,COG1544@1|root,COG1278@2|Bacteria,COG1544@2|Bacteria,1RJ55@1224|Proteobacteria,42TYD@68525|delta/epsilon subdivisions,2WQSG@28221|Deltaproteobacteria,2Z1C9@29|Myxococcales	28221|Deltaproteobacteria	JK	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
k59_1538914_1	1121405.dsmv_1440	1.42e-40	152.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NHP@68525|delta/epsilon subdivisions,2X6U1@28221|Deltaproteobacteria,2MHMI@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM ribonuclease II	-	-	3.1.13.1	ko:K01147,ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
k59_659121_1	649743.HMPREF0972_00138	3.75e-10	64.3	COG4965@1|root,COG4965@2|Bacteria,2HM41@201174|Actinobacteria,4D6BD@85005|Actinomycetales	201174|Actinobacteria	U	Type ii secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	-
k59_1657319_1	56780.SYN_02589	1.29e-139	424.0	COG0458@1|root,COG0458@2|Bacteria,1NPMZ@1224|Proteobacteria,42NF3@68525|delta/epsilon subdivisions,2WM4C@28221|Deltaproteobacteria,2MQ8X@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthetase large chain, oligomerisation	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0661	CPSase_L_D2,CPSase_L_D3,MGS
k59_1597271_1	1123065.ATWL01000007_gene3336	3.19e-64	205.0	2AZHQ@1|root,31RRW@2|Bacteria,2ICDB@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1597271_2	471853.Bcav_1808	2.03e-198	561.0	COG2508@1|root,COG2508@2|Bacteria,2GN0S@201174|Actinobacteria	201174|Actinobacteria	QT	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
k59_306237_2	1123377.AUIV01000025_gene422	5.29e-12	65.1	COG0209@1|root,COG0209@2|Bacteria,1P4EH@1224|Proteobacteria,1RP1A@1236|Gammaproteobacteria,1X3FG@135614|Xanthomonadales	135614|Xanthomonadales	F	COG0209 Ribonucleotide reductase, alpha subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1838448_2	765914.ThisiDRAFT_0941	4.58e-18	83.2	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs	dgt	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0015949,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_370812_1	471853.Bcav_2311	1.16e-122	370.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_717690_1	536019.Mesop_0891	3.49e-43	152.0	COG0006@1|root,COG0006@2|Bacteria,1MVX5@1224|Proteobacteria,2TRMK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Xaa-Pro aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
k59_717690_2	1380391.JIAS01000018_gene1073	1.82e-23	95.9	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,2TSQZ@28211|Alphaproteobacteria,2JR22@204441|Rhodospirillales	204441|Rhodospirillales	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_1013312_2	888056.HMPREF9062_1742	5.08e-48	172.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,4D3BA@85005|Actinomycetales	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_194651_1	572477.Alvin_2860	3.34e-18	81.3	COG2891@1|root,COG2891@2|Bacteria,1RER7@1224|Proteobacteria,1S8VI@1236|Gammaproteobacteria,1WYH2@135613|Chromatiales	135613|Chromatiales	M	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins	-	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
k59_194651_2	349521.HCH_05333	4.94e-83	258.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,1XHGW@135619|Oceanospirillales	135619|Oceanospirillales	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
k59_487646_1	1267005.KB911255_gene2888	2.4e-296	811.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2U25Z@28211|Alphaproteobacteria,3N6AF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Biotin carboxylase	accC	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_1131203_1	1537917.JU82_07400	7.06e-50	176.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2YMI5@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	cation transport ATPase	ccoI	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_604822_1	933262.AXAM01000033_gene1647	7.47e-109	327.0	COG1456@1|root,COG1456@2|Bacteria,1R4RE@1224|Proteobacteria,42M89@68525|delta/epsilon subdivisions,2WJVQ@28221|Deltaproteobacteria,2MI7W@213118|Desulfobacterales	28221|Deltaproteobacteria	C	CO dehydrogenase acetyl-CoA synthase delta subunit	-	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
k59_1845808_1	479432.Sros_3328	2.83e-73	242.0	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria,4EI3M@85012|Streptosporangiales	201174|Actinobacteria	G	Alpha-amylase domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_1602337_1	177439.DP2422	1.36e-65	216.0	COG1040@1|root,COG1262@1|root,COG1040@2|Bacteria,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,42MAT@68525|delta/epsilon subdivisions,2WKY9@28221|Deltaproteobacteria,2MKB1@213118|Desulfobacterales	28221|Deltaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Peptidase_C14
k59_546212_1	157783.LK03_01630	1.88e-28	106.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	sigma (54) modulation protein	yhbH	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
k59_546212_2	1175306.GWL_32920	7.13e-12	64.7	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2VIH5@28216|Betaproteobacteria,47677@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Displays ATPase and GTPase activities	yhbJ	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
k59_1720136_1	446466.Cfla_0251	2.9e-34	128.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4F0VG@85016|Cellulomonadaceae	201174|Actinobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1720136_2	1120949.KB903357_gene4831	5.87e-16	77.4	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,4D9NV@85008|Micromonosporales	201174|Actinobacteria	M	exporter of polyketide	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_194660_1	443143.GM18_3565	6.53e-46	162.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
k59_84662_1	349521.HCH_02592	2.6e-89	286.0	COG2755@1|root,COG2755@2|Bacteria,1MXTS@1224|Proteobacteria,1RTPH@1236|Gammaproteobacteria,1XN5T@135619|Oceanospirillales	135619|Oceanospirillales	E	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
k59_1720145_1	1384056.N787_06560	3.89e-98	301.0	COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,1RRQE@1236|Gammaproteobacteria,1X7AT@135614|Xanthomonadales	135614|Xanthomonadales	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh_C
k59_1602351_1	82654.Pse7367_3837	9.17e-27	117.0	COG0642@1|root,COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG4191@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M6@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_965415_1	367299.JOEE01000003_gene2999	2.77e-67	219.0	COG2244@1|root,COG2244@2|Bacteria,2IP3K@201174|Actinobacteria,4FJE6@85021|Intrasporangiaceae	201174|Actinobacteria	S	polysaccharide biosynthetic process	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN,MatE,Polysacc_synt_3
k59_906496_1	313628.LNTAR_23894	7.77e-66	218.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1490760_1	1348338.ADILRU_0601	8.5e-60	201.0	COG1178@1|root,COG1178@2|Bacteria,2GKPT@201174|Actinobacteria,4FK9A@85023|Microbacteriaceae	201174|Actinobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_1720152_1	981336.F944_02972	1.65e-18	89.7	COG0438@1|root,COG0438@2|Bacteria,1QF9A@1224|Proteobacteria,1RXH5@1236|Gammaproteobacteria,3NMWJ@468|Moraxellaceae	1236|Gammaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_1845845_1	930171.Asphe3_03050	2.35e-94	285.0	COG3833@1|root,COG3833@2|Bacteria,2I2EZ@201174|Actinobacteria,1W8CM@1268|Micrococcaceae	201174|Actinobacteria	G	ABC transporter	malG	-	-	ko:K15772	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
k59_1081981_1	1415166.NONO_c64900	1.14e-10	65.9	2DB8Y@1|root,2Z7TF@2|Bacteria,2GV3U@201174|Actinobacteria,4FWV1@85025|Nocardiaceae	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2236)	lcp	-	-	-	-	-	-	-	-	-	-	-	DUF2236
k59_1013349_1	3988.XP_002538529.1	2.74e-44	159.0	COG0154@1|root,KOG1212@2759|Eukaryota	2759|Eukaryota	J	fatty acid amide hydrolase activity	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_722769_1	1267005.KB911258_gene466	3.41e-55	186.0	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,2TS8J@28211|Alphaproteobacteria,3N6T0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF559,SpoU_methylase
k59_311683_1	977880.pRALTA_0341	9.14e-32	122.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
k59_1602362_1	322710.Avin_38860	3.16e-41	149.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008194,GO:0008289,GO:0008610,GO:0008654,GO:0008915,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0019897,GO:0019898,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	iE2348C_1286.E2348C_0187,iEcolC_1368.EcolC_3478	LpxB
k59_1602362_2	1122201.AUAZ01000020_gene2724	8.39e-79	240.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1RQ4B@1236|Gammaproteobacteria,466FV@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
k59_1490769_1	1267005.KB911258_gene520	6.54e-134	390.0	COG0304@1|root,COG0304@2|Bacteria,1MV30@1224|Proteobacteria,2TRYK@28211|Alphaproteobacteria,3N7XI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	-	ko:K14660	-	-	-	-	ko00000,ko01000	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
k59_428926_1	879212.DespoDRAFT_00445	4.02e-34	137.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,2MI1W@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
k59_311684_1	378806.STAUR_3905	1.68e-28	114.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,42P0G@68525|delta/epsilon subdivisions,2WK7Y@28221|Deltaproteobacteria,2YVQ5@29|Myxococcales	28221|Deltaproteobacteria	P	PBP superfamily domain	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_28970_1	159087.Daro_2223	1.61e-193	545.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,2VMP0@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Pfam Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_84705_1	378806.STAUR_4195	2.51e-87	278.0	2DGYZ@1|root,2ZXTY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1490777_1	61647.LG71_23895	7.25e-25	104.0	COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,1RPU1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494	1.6.5.8	ko:K00346	-	-	-	-	ko00000,ko01000	-	-	-	NQRA,NQRA_SLBB
k59_546254_1	1249627.D779_3036	1.31e-69	228.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1RMA2@1236|Gammaproteobacteria,1WXJP@135613|Chromatiales	135613|Chromatiales	M	PFAM glycosyl transferase family 39	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_1081994_1	105559.Nwat_1837	3.28e-24	99.4	COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,1WXJG@135613|Chromatiales	135613|Chromatiales	L	Belongs to the DnaA family. HdA subfamily	-	-	-	ko:K10763	-	-	-	-	ko00000,ko03032	-	-	-	Bac_DnaA
k59_1720170_1	1123065.ATWL01000001_gene238	5.74e-90	281.0	COG0173@1|root,COG0173@2|Bacteria,2GJHU@201174|Actinobacteria	201174|Actinobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_906533_1	1379270.AUXF01000005_gene376	1.67e-60	199.0	COG0176@1|root,COG0176@2|Bacteria,1ZSZV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
k59_1192867_1	1267005.KB911261_gene2258	1.34e-278	803.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2TRHV@28211|Alphaproteobacteria,3N66K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_906540_1	1123070.KB899247_gene1447	1.99e-26	103.0	COG1136@1|root,COG1136@2|Bacteria,46V4K@74201|Verrucomicrobia,2IW00@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_722785_1	631362.Thi970DRAFT_02462	3.35e-73	231.0	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,1S02U@1236|Gammaproteobacteria,1WX9F@135613|Chromatiales	135613|Chromatiales	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
k59_722785_2	105559.Nwat_0291	7.08e-35	128.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1WW9Z@135613|Chromatiales	135613|Chromatiales	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
k59_1256852_17	675635.Psed_1206	5.37e-53	180.0	2DRE2@1|root,33BCC@2|Bacteria,2I4EF@201174|Actinobacteria,4EE6I@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_907372_2	1049564.TevJSym_ad00290	4.86e-57	198.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,1J980@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2309)	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k59_379098_1	1229276.DI53_1415	3.94e-86	262.0	COG0451@1|root,COG0451@2|Bacteria,4NDV4@976|Bacteroidetes,1IQ44@117747|Sphingobacteriia	976|Bacteroidetes	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
k59_1603001_1	497964.CfE428DRAFT_4539	6.76e-77	251.0	COG0855@1|root,COG0855@2|Bacteria,46SB4@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_429566_1	1384054.N790_11300	2.02e-51	178.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1X4G4@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_429566_2	227377.CBU_1675	1.76e-11	63.5	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1JC8S@118969|Legionellales	118969|Legionellales	M	3-deoxy-8-phosphooctulonate synthase activity	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
k59_1846710_1	446468.Ndas_0616	3.32e-94	278.0	COG0605@1|root,COG0605@2|Bacteria,2GJV8@201174|Actinobacteria,4EIKC@85012|Streptosporangiales	201174|Actinobacteria	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
k59_1013877_2	1132855.KB913035_gene2541	1.14e-08	58.2	COG0642@1|root,COG0642@2|Bacteria,1R49A@1224|Proteobacteria,2VKU5@28216|Betaproteobacteria,2KMC6@206350|Nitrosomonadales	206350|Nitrosomonadales	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_136730_1	1116472.MGMO_223c00120	4.04e-98	308.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1XEQA@135618|Methylococcales	135618|Methylococcales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_1256867_1	1437882.AZRU01000031_gene53	8.31e-14	74.3	COG2207@1|root,COG2207@2|Bacteria,1R5D8@1224|Proteobacteria,1RYEI@1236|Gammaproteobacteria,1YFHQ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_840735_1	2340.JV46_27860	6.21e-78	245.0	COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,1RMAV@1236|Gammaproteobacteria,1JBHG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Involved in arsenical resistance. Thought to form the channel of an arsenite pump	-	-	-	-	-	-	-	-	-	-	-	-	ArsB,CitMHS
k59_1491532_1	525368.HMPREF0591_3841	1.92e-12	68.2	COG0201@1|root,COG0201@2|Bacteria,2GJ26@201174|Actinobacteria,232W8@1762|Mycobacteriaceae	201174|Actinobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_1491532_2	397287.C807_03837	9.92e-36	125.0	COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,24HAJ@186801|Clostridia,27M5N@186928|unclassified Lachnospiraceae	186801|Clostridia	J	binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
k59_429570_1	1353531.AZNX01000037_gene3804	8.34e-80	255.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_429570_2	247634.GPB2148_990	2.36e-88	282.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_1193475_1	639282.DEFDS_2162	8.76e-49	172.0	COG1055@1|root,COG1055@2|Bacteria	2|Bacteria	P	arsenite transmembrane transporter activity	arsA	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_546882_1	1380350.JIAP01000015_gene4001	1.22e-68	234.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria,43HZE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_85536_1	399795.CtesDRAFT_PD3115	2.04e-26	106.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria,4ABGB@80864|Comamonadaceae	28216|Betaproteobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
k59_85536_2	1461579.CCNK01000020_gene516	4.18e-15	75.1	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,1Y7X5@135625|Pasteurellales	135625|Pasteurellales	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_136739_1	580332.Slit_1692	9.7e-72	225.0	COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,2VIG6@28216|Betaproteobacteria,44W7U@713636|Nitrosomonadales	28216|Betaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_195340_2	944560.HMPREF9058_2618	2.97e-38	135.0	COG4635@1|root,COG4635@2|Bacteria,2IQCQ@201174|Actinobacteria,4D5D4@85005|Actinomycetales	201174|Actinobacteria	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
k59_1603017_1	572477.Alvin_1204	1.94e-54	175.0	COG1528@1|root,COG1528@2|Bacteria,1R9ZC@1224|Proteobacteria,1RYVB@1236|Gammaproteobacteria,1WXZ0@135613|Chromatiales	135613|Chromatiales	P	Iron-storage protein	-	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
k59_840748_1	367299.JOEE01000006_gene672	1.54e-52	171.0	COG0745@1|root,COG0745@2|Bacteria,2GJGU@201174|Actinobacteria,4FE75@85021|Intrasporangiaceae	201174|Actinobacteria	KT	Transcriptional regulator	glnR	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
k59_840748_2	710696.Intca_2948	7.43e-05	44.3	COG1977@1|root,COG1977@2|Bacteria,2HXU0@201174|Actinobacteria,4FHQZ@85021|Intrasporangiaceae	201174|Actinobacteria	H	molybdopterin converting factor	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
k59_1663441_1	1267005.KB911255_gene2425	3.09e-48	174.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria,3N888@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
k59_1318589_1	1336235.JAEG01000010_gene3077	3.14e-30	115.0	COG1618@1|root,COG1618@2|Bacteria,1RHUK@1224|Proteobacteria,2U9YB@28211|Alphaproteobacteria,4BKJY@82115|Rhizobiaceae	28211|Alphaproteobacteria	F	Protein of unknown function (DUF2478)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2478
k59_1131958_1	717785.HYPMC_3257	1.57e-74	236.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,3N8ZI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_1720856_2	377629.TERTU_3060	1.5e-20	90.5	COG1416@1|root,COG1416@2|Bacteria,1NAV2@1224|Proteobacteria,1SXJ3@1236|Gammaproteobacteria,2PPIR@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_972246_1	933262.AXAM01000066_gene1678	8.06e-115	338.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,42N9Q@68525|delta/epsilon subdivisions,2WIK1@28221|Deltaproteobacteria,2MIIT@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_1782714_1	1232437.KL661966_gene3173	5.01e-87	278.0	COG2133@1|root,COG2133@2|Bacteria,1NRFC@1224|Proteobacteria,42YAV@68525|delta/epsilon subdivisions,2WTUF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_316160_1	754477.Q7C_2507	1.75e-53	189.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,45ZMV@72273|Thiotrichales	72273|Thiotrichales	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_2,OstA_C
k59_1324436_1	1411123.JQNH01000001_gene3506	8.33e-10	66.6	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2TT3G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	receptor	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
k59_1548200_1	765912.Thimo_1000	1.55e-74	235.0	COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,1RQQA@1236|Gammaproteobacteria,1X0G6@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_433170_1	765910.MARPU_11625	1.7e-100	316.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WW6D@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_1606375_1	1123399.AQVE01000004_gene2539	1.87e-74	244.0	COG1100@1|root,COG1100@2|Bacteria,1QXSV@1224|Proteobacteria,1S5FA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	50S ribosome-binding GTPase	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	DUF697,MMR_HSR1
k59_1606375_2	1123399.AQVE01000004_gene2538	1.55e-118	356.0	COG1100@1|root,COG1100@2|Bacteria,1R1W9@1224|Proteobacteria,1SK3H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF697,MMR_HSR1
k59_199448_1	471853.Bcav_2906	8.33e-56	194.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K05592,ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,Helicase_C
k59_270791_1	477641.MODMU_2054	1.64e-120	381.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2I5GH@201174|Actinobacteria,4EX4D@85013|Frankiales	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc
k59_1372934_1	1279017.AQYJ01000024_gene869	3.15e-34	128.0	COG0598@1|root,COG0598@2|Bacteria,1MWMP@1224|Proteobacteria,1RNDQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Mediates influx of magnesium ions	-	-	-	-	-	-	-	-	-	-	-	-	CorA
k59_1372934_2	1121374.KB891585_gene1948	1.11e-48	170.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Na Pi-Cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans
k59_316844_1	1160137.KB907309_gene5756	6.42e-25	110.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,2GN0J@201174|Actinobacteria,4FV24@85025|Nocardiaceae	201174|Actinobacteria	S	Circularly permuted ATP-grasp type 2	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_1,CP_ATPgrasp_2
k59_386172_2	98439.AJLL01000033_gene3218	6.08e-24	97.8	COG0396@1|root,COG0396@2|Bacteria,1G11H@1117|Cyanobacteria,1JI1N@1189|Stigonemataceae	1117|Cyanobacteria	O	ATPases associated with a variety of cellular activities	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
k59_1548870_1	1123400.KB904780_gene1837	1.72e-31	123.0	COG0515@1|root,COG0515@2|Bacteria,1QVRP@1224|Proteobacteria,1T2I6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K11912,ko:K12132	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	FGE-sulfatase,Pkinase
k59_669141_1	1206731.BAGB01000027_gene2909	2.16e-28	108.0	COG1846@1|root,COG1846@2|Bacteria,2IHP0@201174|Actinobacteria,4G2U4@85025|Nocardiaceae	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
k59_669141_2	1386089.N865_06240	2.36e-14	73.2	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4FEUF@85021|Intrasporangiaceae	201174|Actinobacteria	V	Multidrug ABC transporter ATPase	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_37412_1	1123502.AQXD01000001_gene1176	1.04e-11	66.2	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1X46N@135614|Xanthomonadales	135614|Xanthomonadales	S	permease	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_37412_2	1395571.TMS3_0109800	8.8e-30	119.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	permease	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_1262311_1	1035308.AQYY01000001_gene2224	3.7e-118	348.0	COG0644@1|root,COG0644@2|Bacteria,1TRTQ@1239|Firmicutes,24E1W@186801|Clostridia,261F2@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM geranylgeranyl reductase family	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Lycopene_cycl
k59_1017596_1	1049564.TevJSym_af00530	5.11e-182	534.0	28K74@1|root,2Z9VA@2|Bacteria,1R8MQ@1224|Proteobacteria,1SKKZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1017596_2	1049564.TevJSym_af00520	2.4e-48	159.0	2DM5Y@1|root,31UPK@2|Bacteria,1NUSA@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_609932_1	387631.Asulf_02173	7.26e-11	68.9	COG0582@1|root,arCOG01241@2157|Archaea,2XUBA@28890|Euryarchaeota	28890|Euryarchaeota	L	integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_492688_1	927658.AJUM01000047_gene3034	6.25e-114	353.0	COG3408@1|root,COG3408@2|Bacteria,4NESP@976|Bacteroidetes,2FMGH@200643|Bacteroidia	976|Bacteroidetes	G	Alpha-L-rhamnosidase N-terminal domain protein	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
k59_92740_1	335543.Sfum_0551	3.56e-56	194.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2MQTC@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_973548_1	1530186.JQEY01000001_gene1326	2.95e-43	151.0	COG1910@1|root,COG1910@2|Bacteria,1MVS4@1224|Proteobacteria,2TU96@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG1910, Periplasmic molybdate-binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,PBP_like
k59_433883_1	1123024.AUII01000007_gene4815	8e-25	106.0	COG3324@1|root,COG3324@2|Bacteria,2GJFC@201174|Actinobacteria,4E3XB@85010|Pseudonocardiales	201174|Actinobacteria	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
k59_37423_1	879212.DespoDRAFT_03599	1.16e-21	92.8	COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,42R2R@68525|delta/epsilon subdivisions,2WMSJ@28221|Deltaproteobacteria,2MJRA@213118|Desulfobacterales	28221|Deltaproteobacteria	K	transcriptional regulator, AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_AsnC-type
k59_1496794_1	76114.ebA3304	3.48e-31	116.0	COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,2VRM9@28216|Betaproteobacteria,2KVMU@206389|Rhodocyclales	206389|Rhodocyclales	F	phosphoribosyltransferase	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_1325753_1	1089545.KB913037_gene3460	2.69e-42	167.0	COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,2GISC@201174|Actinobacteria,4E1FM@85010|Pseudonocardiales	201174|Actinobacteria	L	SNF2 family N-terminal domain	helZ	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
k59_782726_1	351348.Maqu_1432	6.89e-60	202.0	COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,1RPDG@1236|Gammaproteobacteria,469FR@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
k59_551284_1	85643.Tmz1t_3851	6.37e-12	71.2	COG1639@1|root,COG2199@1|root,COG1639@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VHDQ@28216|Betaproteobacteria,2KW16@206389|Rhodocyclales	206389|Rhodocyclales	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HDOD,Response_reg
k59_1197969_1	1121405.dsmv_1462	9.89e-32	111.0	COG4311@1|root,COG4311@2|Bacteria,1Q23E@1224|Proteobacteria,42UXF@68525|delta/epsilon subdivisions,2WR1S@28221|Deltaproteobacteria,2MKEP@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Sarcosine oxidase, delta subunit family	-	-	1.5.3.1	ko:K00304	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxD
k59_1197969_2	1121405.dsmv_1463	3.74e-140	426.0	COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,42P3Z@68525|delta/epsilon subdivisions,2WKRN@28221|Deltaproteobacteria,2MJ14@213118|Desulfobacterales	28221|Deltaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer2_BFD,GCV_T,GCV_T_C,Pyr_redox_2
k59_1262332_1	631362.Thi970DRAFT_00020	0.000255	42.7	COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria,1WWAM@135613|Chromatiales	135613|Chromatiales	H	Uroporphyrinogen III synthase	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
k59_1262332_2	283942.IL2558	2.63e-57	188.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,2QF1G@267893|Idiomarinaceae	1236|Gammaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_4275,iECH74115_1262.ECH74115_5243,iECIAI1_1343.ECIAI1_3991,iECO103_1326.ECO103_4362,iECO111_1330.ECO111_4628,iECO26_1355.ECO26_4784,iECSE_1348.ECSE_4086,iEKO11_1354.EKO11_4554,iPC815.YPO3849	Porphobil_deam,Porphobil_deamC
k59_492710_2	1122194.AUHU01000004_gene1370	9.72e-126	377.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,4664R@72275|Alteromonadaceae	1236|Gammaproteobacteria	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_1372976_1	1043493.BBLU01000002_gene1817	3.52e-120	357.0	COG2223@1|root,COG2223@2|Bacteria,2GJ1I@201174|Actinobacteria	201174|Actinobacteria	P	Major Facilitator	narU	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	iNJ661.Rv0267	MFS_1
k59_1017625_1	1306174.JODP01000003_gene1921	6.33e-127	372.0	COG1672@1|root,COG1672@2|Bacteria,2GWBV@201174|Actinobacteria	201174|Actinobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
k59_1607046_1	1049564.TevJSym_ap00050	2.92e-56	196.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J57S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	cation transport ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
k59_727680_1	1265490.JHVY01000022_gene2440	2.65e-07	57.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the peptidase S1C family	degS	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0051788,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564	-	ko:K04691,ko:K04772	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
k59_727680_2	1123368.AUIS01000007_gene2683	9.1e-51	169.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RQJD@1236|Gammaproteobacteria,2NBYE@225057|Acidithiobacillales	225057|Acidithiobacillales	K	LysR substrate binding domain	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_316897_1	156889.Mmc1_0142	4.34e-13	66.6	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2U797@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.31,3.5.1.88	ko:K01450,ko:K01462	ko00270,ko00630,map00270,map00630	-	R00653	RC00165,RC00323	ko00000,ko00001,ko01000	-	-	-	Pep_deformylase
k59_316897_2	1158756.AQXQ01000011_gene890	1.49e-46	165.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1WWDN@135613|Chromatiales	135613|Chromatiales	S	PFAM Peptidoglycan-binding lysin domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_1262351_1	765910.MARPU_04675	3.52e-129	380.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,1WW94@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_1496827_1	1182590.BN5_02569	2.6e-45	156.0	COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,1YEWP@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	EH	Amino-transferase class IV	pabC	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008696,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0019842,GO:0030170,GO:0034641,GO:0036094,GO:0042558,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_177,iE2348C_1286.E2348C_1188,iECED1_1282.ECED1_1239,iECNA114_1301.ECNA114_1153,iECOK1_1307.ECOK1_1203,iECS88_1305.ECS88_1110,iECSF_1327.ECSF_0995,iECUMN_1333.ECUMN_1273,iJN746.PP_1917,iPC815.YPO1603,iUMN146_1321.UM146_11845,iUTI89_1310.UTI89_C1222,ic_1306.c1366	Aminotran_4
k59_1496827_2	519989.ECTPHS_03232	6.09e-11	64.7	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1WWK3@135613|Chromatiales	135613|Chromatiales	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_1372986_1	983545.Glaag_0081	7.99e-81	251.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,4642P@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG1194 A G-specific DNA glycosylase	mutY	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
k59_140963_1	1160721.RBI_I00217	1.25e-10	71.2	COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,247V6@186801|Clostridia,3WHXB@541000|Ruminococcaceae	186801|Clostridia	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase
k59_492722_1	710696.Intca_3112	2.51e-190	539.0	COG3547@1|root,COG3547@2|Bacteria,2IBF5@201174|Actinobacteria	201174|Actinobacteria	L	Transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_270889_1	1121405.dsmv_0483	2.49e-20	93.2	COG1418@1|root,COG1418@2|Bacteria,1P7YA@1224|Proteobacteria,42KZ8@68525|delta/epsilon subdivisions,2WJG1@28221|Deltaproteobacteria,2MHS7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
k59_1136044_1	34007.IT40_20955	2.67e-86	260.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,2PW77@265|Paracoccus	28211|Alphaproteobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_1372992_1	765912.Thimo_1819	1.7e-84	271.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1WW4U@135613|Chromatiales	135613|Chromatiales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_1372992_2	1163617.SCD_n01108	3.03e-06	48.1	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2VHFD@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_914636_2	519989.ECTPHS_07062	2.21e-49	169.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1WWH3@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_37491_1	713586.KB900536_gene2226	5e-53	188.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
k59_37491_2	519989.ECTPHS_01169	1.12e-31	120.0	29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,1SBT1@1236|Gammaproteobacteria,1WYAZ@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4390)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4390
k59_37491_3	105559.Nwat_3073	3.54e-130	386.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1WVWG@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
k59_973642_1	460265.Mnod_4690	0.000184	50.4	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,1JU2Z@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	PFAM transcriptional regulator domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
k59_914641_1	997346.HMPREF9374_3953	4e-30	118.0	COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,4HEU9@91061|Bacilli,27BTE@186824|Thermoactinomycetaceae	91061|Bacilli	P	PhoU domain	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_914658_1	2340.JV46_03830	9.03e-52	177.0	COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,1RRKZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
k59_914659_2	318167.Sfri_2283	1.93e-38	132.0	COG1320@1|root,COG1320@2|Bacteria,1QB60@1224|Proteobacteria,1T6PT@1236|Gammaproteobacteria,2QC73@267890|Shewanellaceae	1236|Gammaproteobacteria	P	TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_492745_1	590998.Celf_1618	9.29e-64	208.0	COG1589@1|root,COG1589@2|Bacteria,2H4A4@201174|Actinobacteria,4F190@85016|Cellulomonadaceae	201174|Actinobacteria	M	POTRA domain, FtsQ-type	ftsQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
k59_1607082_1	1442599.JAAN01000031_gene1435	2.78e-79	248.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1X31Z@135614|Xanthomonadales	135614|Xanthomonadales	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
k59_1854157_1	1122599.AUGR01000022_gene1626	3.47e-48	157.0	COG1432@1|root,COG1432@2|Bacteria,1MUAE@1224|Proteobacteria,1S47Z@1236|Gammaproteobacteria,1XJQI@135619|Oceanospirillales	135619|Oceanospirillales	S	nuclease	-	-	-	-	-	-	-	-	-	-	-	-	NYN
k59_1854157_2	1279015.KB908457_gene2194	1.33e-08	55.8	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RQ36@1236|Gammaproteobacteria,1Y3TY@135624|Aeromonadales	135624|Aeromonadales	L	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K05591	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DEAD,DbpA,Helicase_C
k59_433946_2	472759.Nhal_3602	7.32e-92	280.0	COG1180@1|root,COG1180@2|Bacteria,1R8XY@1224|Proteobacteria,1T0C7@1236|Gammaproteobacteria,1X2MB@135613|Chromatiales	135613|Chromatiales	O	Radical SAM superfamily	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_1433059_1	1121035.AUCH01000013_gene3091	1.04e-93	287.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,2VJT0@28216|Betaproteobacteria,2KVAX@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hoxH	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
k59_973676_2	479435.Kfla_2764	7.34e-128	383.0	COG1233@1|root,COG1233@2|Bacteria,2HZ9J@201174|Actinobacteria,4DRF3@85009|Propionibacteriales	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_92878_1	1005048.CFU_3252	3.48e-39	154.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,473ZF@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_727729_1	439235.Dalk_1125	2.64e-92	290.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42M9D@68525|delta/epsilon subdivisions,2WJ43@28221|Deltaproteobacteria,2MI8A@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_433953_1	1144275.COCOR_01127	1.98e-28	106.0	COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,42TMP@68525|delta/epsilon subdivisions,2WR9C@28221|Deltaproteobacteria,2YV89@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
k59_433953_2	1192034.CAP_3038	4.04e-16	76.3	COG0764@1|root,COG0764@2|Bacteria,1QSTA@1224|Proteobacteria,4355J@68525|delta/epsilon subdivisions,2X9PY@28221|Deltaproteobacteria,2Z23M@29|Myxococcales	28221|Deltaproteobacteria	I	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_492762_2	272123.Anacy_1537	3.04e-54	177.0	COG0454@1|root,COG0456@2|Bacteria,1G1VS@1117|Cyanobacteria,1HJUE@1161|Nostocales	1117|Cyanobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1136076_1	1410620.SHLA_3c000380	1.5e-15	75.1	COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,2TUR9@28211|Alphaproteobacteria,4BGN6@82115|Rhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1136076_2	452637.Oter_2036	4.98e-33	122.0	COG2353@1|root,COG2353@2|Bacteria,46WNH@74201|Verrucomicrobia,3K86P@414999|Opitutae	414999|Opitutae	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
k59_386359_1	472759.Nhal_0095	2.31e-79	250.0	COG0297@1|root,COG0297@2|Bacteria,1P7F2@1224|Proteobacteria,1RZVJ@1236|Gammaproteobacteria,1WX4C@135613|Chromatiales	135613|Chromatiales	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	-	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_316955_1	1056820.KB900700_gene1162	1.12e-60	201.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,2PMTN@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	P	TrkA-N domain	trkA	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0015075,GO:0015672,GO:0016020,GO:0022857,GO:0030001,GO:0034220,GO:0051179,GO:0051234,GO:0055085,GO:0098655	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	iE2348C_1286.E2348C_3552	TrkA_C,TrkA_N
k59_316955_2	1026882.MAMP_02232	1.04e-30	118.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,45ZP9@72273|Thiotrichales	72273|Thiotrichales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_1203541_2	1075090.GOAMR_40_01290	8.33e-26	102.0	2B3MQ@1|root,31WB3@2|Bacteria,2HXRR@201174|Actinobacteria,4GGPY@85026|Gordoniaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1203541_3	1120797.KB908268_gene3391	4e-45	153.0	COG2409@1|root,COG2409@2|Bacteria,2IH0P@201174|Actinobacteria	201174|Actinobacteria	S	Drug exporters of the RND superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_278288_2	1283300.ATXB01000001_gene1541	2.83e-44	149.0	COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,1S6AJ@1236|Gammaproteobacteria,1XF41@135618|Methylococcales	135618|Methylococcales	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
k59_278288_3	983545.Glaag_3084	4.83e-29	113.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,466CJ@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iSFV_1184.SFV_0382	AIRS,AIRS_C
k59_1438639_1	269797.Mbar_A3217	5.46e-75	236.0	COG0675@1|root,arCOG00684@2157|Archaea,2XSWB@28890|Euryarchaeota,2NBGF@224756|Methanomicrobia	224756|Methanomicrobia	L	Probable transposase	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
k59_615601_1	754476.Q7A_1268	8.22e-152	436.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,4605U@72273|Thiotrichales	72273|Thiotrichales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
k59_1503060_1	314285.KT71_10342	2.9e-21	99.4	COG3107@1|root,COG3107@2|Bacteria,1NRRE@1224|Proteobacteria,1SJWD@1236|Gammaproteobacteria,1J91M@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	LppC putative lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	LppC
k59_1673604_1	631362.Thi970DRAFT_04905	2.61e-50	163.0	COG5266@1|root,COG5266@2|Bacteria,1NBJ8@1224|Proteobacteria,1SGZC@1236|Gammaproteobacteria,1X2PI@135613|Chromatiales	135613|Chromatiales	P	PFAM Nickel transport complex, NikM subunit, transmembrane	-	-	-	ko:K16915	ko02010,map02010	M00246	-	-	ko00000,ko00001,ko00002,ko02000	-	-	-	-
k59_1673604_3	631362.Thi970DRAFT_04903	2.02e-34	122.0	COG0310@1|root,COG0310@2|Bacteria,1RJRC@1224|Proteobacteria,1S6H0@1236|Gammaproteobacteria,1WX9R@135613|Chromatiales	135613|Chromatiales	P	PFAM Cobalt uptake substrate-specific transmembrane region	-	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
k59_205313_1	644966.Tmar_1896	2.61e-43	157.0	COG3547@1|root,COG3547@2|Bacteria,1VI3C@1239|Firmicutes,25AXZ@186801|Clostridia	186801|Clostridia	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_983585_1	1417296.U879_08095	5.22e-152	432.0	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,2U4AQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_1022329_1	1232410.KI421414_gene2846	5.42e-29	115.0	COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,42UW6@68525|delta/epsilon subdivisions,2WQ4A@28221|Deltaproteobacteria,43T0K@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF374)	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
k59_1788166_1	631362.Thi970DRAFT_00535	1.88e-50	165.0	COG2920@1|root,COG2920@2|Bacteria,1N6BU@1224|Proteobacteria,1S6FJ@1236|Gammaproteobacteria,1WYPC@135613|Chromatiales	135613|Chromatiales	P	part of a sulfur-relay system	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_675016_1	1043493.BBLU01000018_gene1582	2.82e-35	129.0	COG1266@1|root,COG1266@2|Bacteria,2GYQG@201174|Actinobacteria	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_1268669_1	1469245.JFBG01000063_gene2350	7.12e-37	136.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,1RNYA@1236|Gammaproteobacteria,1WW0S@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III, delta'	-	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
k59_1094411_2	631362.Thi970DRAFT_02007	2e-69	233.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1WX2G@135613|Chromatiales	135613|Chromatiales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
k59_1554501_1	1283300.ATXB01000001_gene2448	1.7e-201	583.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1XE70@135618|Methylococcales	135618|Methylococcales	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HTH_12,OB_RNB,RNB,S1
k59_983623_1	582899.Hden_1945	1.07e-112	326.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,2TQK3@28211|Alphaproteobacteria,3N6IK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
k59_787479_1	710696.Intca_0795	2.72e-119	352.0	COG3547@1|root,COG3547@2|Bacteria,2IBF5@201174|Actinobacteria	201174|Actinobacteria	L	Transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1335812_1	1537994.JQFW01000022_gene191	2.1e-70	238.0	COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,1T1KJ@1236|Gammaproteobacteria,46621@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	COG1505 Serine proteases of the peptidase family S9A	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
k59_675037_1	883126.HMPREF9710_00679	5.85e-42	157.0	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2VMJF@28216|Betaproteobacteria,473TW@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Peptidase family M13	-	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
k59_1438667_1	765911.Thivi_0266	1.93e-84	262.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,1S03J@1236|Gammaproteobacteria,1WYH5@135613|Chromatiales	135613|Chromatiales	S	Major facilitator superfamily	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_557003_1	977880.RALTA_A2047	2.71e-73	226.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2VQI2@28216|Betaproteobacteria,1K0ZJ@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_396123_1	335543.Sfum_1936	3.13e-83	260.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria,2MRBS@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_146775_1	1123065.ATWL01000002_gene1723	1.82e-204	578.0	COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_146775_2	593907.Celgi_2043	3.16e-07	51.2	COG1418@1|root,COG1418@2|Bacteria,2I9DW@201174|Actinobacteria	201174|Actinobacteria	M	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
k59_924576_1	439235.Dalk_1684	1.05e-30	111.0	2CJPW@1|root,32SAH@2|Bacteria,1NAJ3@1224|Proteobacteria,42W32@68525|delta/epsilon subdivisions,2WQGF@28221|Deltaproteobacteria,2MKQ3@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1731020_1	187272.Mlg_1997	5.32e-17	78.2	COG2894@1|root,COG2894@2|Bacteria,1MUEU@1224|Proteobacteria,1RNJ0@1236|Gammaproteobacteria,1WWCA@135613|Chromatiales	135613|Chromatiales	D	Belongs to the ParA family	-	-	-	ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
k59_1731020_2	243233.MCA3068	8.55e-32	113.0	COG0851@1|root,COG0851@2|Bacteria,1N6QD@1224|Proteobacteria,1SC8W@1236|Gammaproteobacteria,1XFJ0@135618|Methylococcales	135618|Methylococcales	D	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell	minE	-	-	ko:K03608	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	MinE
k59_1731020_3	572477.Alvin_0412	4.97e-74	233.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,1WWQK@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_1439358_3	479431.Namu_2846	1.36e-105	315.0	COG0561@1|root,COG0561@2|Bacteria,2IGRF@201174|Actinobacteria	201174|Actinobacteria	S	Had-superfamily hydrolase, subfamily iib	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
k59_206037_1	471853.Bcav_3154	9.87e-118	370.0	COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1204231_1	1282876.BAOK01000001_gene2184	1.85e-102	311.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2TS4Y@28211|Alphaproteobacteria,4BPM9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_984823_1	335543.Sfum_3497	4.66e-25	107.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,42TI5@68525|delta/epsilon subdivisions,2WQR8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_499097_1	642227.HA49_19920	4.26e-37	135.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,4BTQR@82986|Tatumella	1236|Gammaproteobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_557672_1	497321.C664_07748	7.69e-18	82.8	COG0154@1|root,COG0154@2|Bacteria,1MWWQ@1224|Proteobacteria,2VKHW@28216|Betaproteobacteria,2KZSN@206389|Rhodocyclales	206389|Rhodocyclales	J	Belongs to the amidase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
k59_1439364_1	644282.Deba_1506	2.58e-24	108.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,42N1B@68525|delta/epsilon subdivisions,2WJ25@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM FAD dependent oxidoreductase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
k59_925735_1	945543.VIBR0546_04819	1.8e-39	145.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1XU9H@135623|Vibrionales	135623|Vibrionales	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	visC	-	-	ko:K18800	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04987,R08768	RC00046	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_925735_3	357808.RoseRS_4311	7.72e-38	141.0	COG1960@1|root,COG1960@2|Bacteria,2G7V8@200795|Chloroflexi,375QJ@32061|Chloroflexia	32061|Chloroflexia	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
k59_1503738_1	631362.Thi970DRAFT_00335	8.73e-65	225.0	COG4678@1|root,COG4678@2|Bacteria,1MXCR@1224|Proteobacteria,1RPZR@1236|Gammaproteobacteria,1WW1Z@135613|Chromatiales	135613|Chromatiales	G	PFAM TraG-like protein, N-terminal region	-	-	-	ko:K12056	-	-	-	-	ko00000,ko02044	3.A.7.11.1	-	-	TraG_N
k59_557675_1	1123360.thalar_02390	1.25e-78	244.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2TU72@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
k59_1865318_1	768671.ThimaDRAFT_3211	3.15e-60	200.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,1RPP2@1236|Gammaproteobacteria,1WXM4@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_1865318_2	765911.Thivi_3691	2.22e-22	95.9	COG0642@1|root,COG1225@1|root,COG1225@2|Bacteria,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,1RPP2@1236|Gammaproteobacteria,1WXM4@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_557680_2	28444.JODQ01000005_gene1223	8.63e-18	82.0	COG1181@1|root,COG1181@2|Bacteria,2GRWM@201174|Actinobacteria,4EFUD@85012|Streptosporangiales	201174|Actinobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_1269373_1	330214.NIDE2540	7.72e-70	225.0	COG0044@1|root,COG0044@2|Bacteria,3J0D7@40117|Nitrospirae	40117|Nitrospirae	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_1379325_1	1448139.AI20_05815	4.92e-132	406.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1Y3TQ@135624|Aeromonadales	135624|Aeromonadales	F	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_984866_2	146922.JOFU01000003_gene6968	5.31e-10	61.6	COG1640@1|root,COG1640@2|Bacteria,2GM5Z@201174|Actinobacteria	201174|Actinobacteria	G	4-alpha-glucanotransferase	malQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_1439380_1	1121935.AQXX01000130_gene2470	1.28e-43	167.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1XI7D@135619|Oceanospirillales	135619|Oceanospirillales	H	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_6,TPR_8
k59_1022926_1	977880.RALTA_B2190	2.09e-28	120.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,1K38N@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Phospholipase D Transphosphatidylase	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_1731709_1	1304865.JAGF01000001_gene2382	1.91e-63	210.0	COG5607@1|root,COG5607@2|Bacteria,2GJZH@201174|Actinobacteria	201174|Actinobacteria	S	CHAD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
k59_1095095_1	132113.XP_003494839.1	2.82e-87	292.0	COG1643@1|root,KOG0922@2759|Eukaryota,38C5G@33154|Opisthokonta,3BARI@33208|Metazoa,3CUB7@33213|Bilateria,41UE5@6656|Arthropoda,3SK7J@50557|Insecta,46FIZ@7399|Hymenoptera	33208|Metazoa	A	ATP-dependent RNA helicase	-	-	3.6.4.13	ko:K12818	ko03040,map03040	-	-	-	ko00000,ko00001,ko01000,ko03041	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_984884_1	272569.rrnAC0151	2.29e-31	125.0	arCOG04532@1|root,arCOG04532@2157|Archaea,2XV2M@28890|Euryarchaeota,23S53@183963|Halobacteria	183963|Halobacteria	P	COG1914 Mn2 and Fe2 transporters of the NRAMP family	-	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
k59_925776_1	375286.mma_2106	2.25e-81	249.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2VHS0@28216|Betaproteobacteria,472PA@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
k59_925776_2	1408164.MOLA814_02225	7e-10	58.5	COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2VHMQ@28216|Betaproteobacteria,1KPY7@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	L	DNA replication, recombination and repair	alkA	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
k59_557704_1	1479238.JQMZ01000001_gene911	5.18e-09	57.4	COG0189@1|root,COG4067@1|root,COG0189@2|Bacteria,COG4067@2|Bacteria,1MX62@1224|Proteobacteria,2TRUH@28211|Alphaproteobacteria,43W5H@69657|Hyphomonadaceae	28211|Alphaproteobacteria	HJO	Belongs to the RimK family	rimK	-	6.3.2.32	ko:K05844,ko:K14940	ko00680,ko01120,map00680,map01120	-	R09401	RC00064,RC00090	ko00000,ko00001,ko01000,ko03009	-	-	-	RimK,Zn_protease
k59_1503780_1	1454010.JEOE01000005_gene1723	2.28e-52	171.0	COG0589@1|root,COG0589@2|Bacteria,2GUPR@201174|Actinobacteria,4F2S1@85016|Cellulomonadaceae	201174|Actinobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1503780_2	1035308.AQYY01000002_gene760	1.44e-13	68.2	COG0239@1|root,COG0239@2|Bacteria	2|Bacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
k59_1674345_1	1288298.rosmuc_04036	1.66e-143	413.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,46PY7@74030|Roseovarius	28211|Alphaproteobacteria	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1865367_1	83406.HDN1F_15700	1.51e-144	431.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1J5A1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the ClpA ClpB family	clpA	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_206086_1	1209984.BN978_05098	6.89e-74	248.0	COG5412@1|root,COG5412@2|Bacteria,2IB04@201174|Actinobacteria,237Q0@1762|Mycobacteriaceae	201174|Actinobacteria	S	phage tail tape measure protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1337110_1	991905.SL003B_1090	3.78e-39	142.0	COG2843@1|root,COG2843@2|Bacteria,1PH1V@1224|Proteobacteria,2VENS@28211|Alphaproteobacteria,4BT2N@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
k59_1337110_2	1131553.JIBI01000004_gene351	5.57e-49	167.0	COG1073@1|root,COG1073@2|Bacteria,1N595@1224|Proteobacteria	1224|Proteobacteria	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
k59_557707_1	1095767.CAHD01000025_gene1724	1.68e-123	360.0	COG0382@1|root,COG0382@2|Bacteria,2GKJ2@201174|Actinobacteria,4F0NS@85016|Cellulomonadaceae	201174|Actinobacteria	H	UbiA prenyltransferase family	-	-	-	ko:K20616	-	-	-	-	ko00000	-	-	-	UbiA
k59_46091_1	1122132.AQYH01000002_gene1283	1.86e-126	380.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria,4BAGU@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_103845_1	314278.NB231_09408	3.79e-64	216.0	COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,1S0W3@1236|Gammaproteobacteria,1WX5N@135613|Chromatiales	135613|Chromatiales	KL	DNA RNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SWIM
k59_323359_1	697282.Mettu_2577	9.41e-110	321.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,1RP3R@1236|Gammaproteobacteria,1XDXU@135618|Methylococcales	135618|Methylococcales	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
k59_323359_2	697282.Mettu_2578	3.66e-13	63.9	COG3114@1|root,COG3114@2|Bacteria,1NGBM@1224|Proteobacteria,1SGGH@1236|Gammaproteobacteria,1XFW4@135618|Methylococcales	135618|Methylococcales	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	-	-	-	ko:K02196	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.107	-	-	CcmD
k59_323359_3	323261.Noc_0944	6.12e-52	168.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,1S5VA@1236|Gammaproteobacteria,1WXYI@135613|Chromatiales	135613|Chromatiales	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
k59_1204300_1	1463903.JOIZ01000024_gene6306	6.1e-10	62.0	COG0019@1|root,COG0019@2|Bacteria,2GIT5@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the Orn Lys Arg decarboxylase class-II family	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_1022957_1	1121441.AUCX01000007_gene1067	1.32e-88	266.0	COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,42NVB@68525|delta/epsilon subdivisions,2WK6R@28221|Deltaproteobacteria,2M88C@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfE	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
k59_734433_1	1157637.KB892110_gene4250	7.71e-179	521.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria	201174|Actinobacteria	P	Sulfate transporter	-	GO:0000103,GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006790,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008152,GO:0008272,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0017076,GO:0019001,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0097159,GO:0098656,GO:0098660,GO:0098661,GO:1901265,GO:1901363,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1561088_1	1255043.TVNIR_2414	7.29e-71	233.0	COG0709@1|root,COG1252@1|root,COG0709@2|Bacteria,COG1252@2|Bacteria,1MWFG@1224|Proteobacteria,1RQ5Q@1236|Gammaproteobacteria,1X13W@135613|Chromatiales	135613|Chromatiales	CE	AIR synthase related protein, N-terminal domain	-	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C,Pyr_redox_2
k59_1028303_1	58123.JOFJ01000002_gene2594	6.93e-89	273.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4EGFY@85012|Streptosporangiales	201174|Actinobacteria	BQ	Histone deacetylase domain	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
k59_1561091_1	1415778.JQMM01000001_gene1103	7.48e-57	183.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,1S3ST@1236|Gammaproteobacteria,1J5Z2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016043,GO:0016829,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0022607,GO:0034214,GO:0042802,GO:0043170,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0051259,GO:0061799,GO:0065003,GO:0071704,GO:0071840,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoaC
k59_54421_1	264462.Bd0254	2.14e-43	159.0	COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391	2.7.7.7	ko:K02342,ko:K03703,ko:K04096	ko00230,ko00240,ko01100,ko03030,ko03420,ko03430,ko03440,map00230,map00240,map01100,map03030,map03420,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DUF4357,GIY-YIG,RNase_T
k59_934459_1	1469245.JFBG01000012_gene931	8.3e-90	268.0	COG0607@1|root,COG0607@2|Bacteria,1REGB@1224|Proteobacteria,1S580@1236|Gammaproteobacteria,1X2R1@135613|Chromatiales	135613|Chromatiales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_54425_1	243233.MCA2982	1.02e-34	126.0	COG0637@1|root,COG0637@2|Bacteria,1QTT8@1224|Proteobacteria,1T1GC@1236|Gammaproteobacteria,1XE2I@135618|Methylococcales	135618|Methylococcales	S	PFAM Haloacid dehalogenase-like hydrolase	-	-	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_54425_2	1219375.CM002139_gene3664	1.32e-63	214.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1X3R5@135614|Xanthomonadales	135614|Xanthomonadales	JKL	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C,RhlB
k59_287297_1	649638.Trad_1985	7.43e-70	227.0	COG1488@1|root,COG1488@2|Bacteria,1WIWH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
k59_112735_1	335543.Sfum_1999	3.98e-93	289.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2WJXY@28221|Deltaproteobacteria,2MQTE@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_934469_1	448385.sce5416	1.29e-12	71.2	COG1858@1|root,COG1858@2|Bacteria,1QTHX@1224|Proteobacteria,43F3A@68525|delta/epsilon subdivisions,2WZD5@28221|Deltaproteobacteria,2YUR6@29|Myxococcales	28221|Deltaproteobacteria	C	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG
k59_934469_2	1144275.COCOR_07597	2.1e-17	82.0	COG0500@1|root,COG2226@2|Bacteria,1RB6K@1224|Proteobacteria,43DG1@68525|delta/epsilon subdivisions,2X8N0@28221|Deltaproteobacteria,2YWMM@29|Myxococcales	28221|Deltaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_740344_1	765912.Thimo_1463	2.92e-78	254.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1WWDE@135613|Chromatiales	135613|Chromatiales	T	Belongs to the PEP-utilizing enzyme family	-	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_1209818_2	1266909.AUAG01000014_gene2246	8.96e-43	142.0	COG2154@1|root,COG2154@2|Bacteria,1RH99@1224|Proteobacteria,1SAUS@1236|Gammaproteobacteria,1WZT2@135613|Chromatiales	135613|Chromatiales	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
k59_211834_1	1286106.MPL1_11683	2.9e-39	148.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,45ZVU@72273|Thiotrichales	72273|Thiotrichales	M	PFAM AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA
k59_504842_1	338963.Pcar_2558	2.41e-56	201.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,43TNR@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS,PAS_3,PAS_9,Response_reg
k59_1101534_1	384765.SIAM614_02531	6.94e-53	177.0	COG1566@1|root,COG1566@2|Bacteria,1MWG0@1224|Proteobacteria,2TRI4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_153477_1	405948.SACE_1969	1.99e-43	146.0	COG1670@1|root,COG1670@2|Bacteria,2H4AD@201174|Actinobacteria,4E4W2@85010|Pseudonocardiales	201174|Actinobacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_54465_1	1033730.CAHG01000015_gene775	1.68e-109	325.0	COG2170@1|root,COG2170@2|Bacteria,2GKAA@201174|Actinobacteria,4DNZR@85009|Propionibacteriales	201174|Actinobacteria	S	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	ybdK	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
k59_54465_2	1122933.JNIY01000003_gene688	7.79e-83	260.0	COG1041@1|root,COG1041@2|Bacteria,2I2EV@201174|Actinobacteria,4F25H@85016|Cellulomonadaceae	201174|Actinobacteria	L	tRNA (guanine-N2-)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1209831_1	1123065.ATWL01000021_gene3660	1.63e-50	171.0	COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria	201174|Actinobacteria	E	Branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_446207_1	648757.Rvan_1323	2.9e-141	406.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2TRP3@28211|Alphaproteobacteria,3N69W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_857078_1	768671.ThimaDRAFT_0612	3.18e-65	203.0	2C4C9@1|root,33X4G@2|Bacteria,1NW2V@1224|Proteobacteria,1SPB4@1236|Gammaproteobacteria,1X0VY@135613|Chromatiales	135613|Chromatiales	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
k59_406279_1	1124780.ANNU01000051_gene2088	5.7e-38	149.0	COG1643@1|root,COG1643@2|Bacteria,4NFJ7@976|Bacteroidetes,47KRZ@768503|Cytophagia	976|Bacteroidetes	L	DEAD DEAH box helicase	-	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
k59_1028361_1	1469245.JFBG01000019_gene1132	4.84e-97	307.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,1S0DI@1236|Gammaproteobacteria,1X0D5@135613|Chromatiales	135613|Chromatiales	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	ko:K16886	-	-	-	-	ko00000	-	-	-	Fer4,FlpD
k59_1680051_1	344747.PM8797T_21498	2.64e-61	209.0	COG0515@1|root,COG0515@2|Bacteria,2IXG3@203682|Planctomycetes	203682|Planctomycetes	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	HDOD,Pkinase,dCache_1
k59_622029_1	717785.HYPMC_4783	1.5e-63	205.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2TQZX@28211|Alphaproteobacteria,3N6IB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_1874358_1	270374.MELB17_17679	8.62e-57	188.0	COG0596@1|root,COG0596@2|Bacteria,1MUVB@1224|Proteobacteria,1RP4M@1236|Gammaproteobacteria,46CWZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Alpha/beta hydrolase family	-	-	3.8.1.3	ko:K01561	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_792713_1	765911.Thivi_1410	9.75e-43	149.0	29Y76@1|root,30K0S@2|Bacteria,1N3S0@1224|Proteobacteria,1SNR1@1236|Gammaproteobacteria,1X0NU@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF3611)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3611
k59_1346140_1	1415778.JQMM01000001_gene29	1.46e-108	325.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,1J4SK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0050896,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
k59_1737508_1	367299.JOEE01000001_gene1520	2.26e-49	169.0	COG0534@1|root,COG0534@2|Bacteria,2GJE3@201174|Actinobacteria,4FFX8@85021|Intrasporangiaceae	201174|Actinobacteria	V	Multidrug transporter MatE	dinF	-	-	-	-	-	-	-	-	-	-	-	MatE
k59_1101557_1	913865.DOT_1508	1.47e-67	236.0	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,26166@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_6,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Pyr_redox_2,Pyr_redox_3
k59_1276169_2	710696.Intca_1186	4.06e-152	441.0	COG0438@1|root,COG0438@2|Bacteria,2IEGK@201174|Actinobacteria,4FE9A@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
k59_1209846_1	1049564.TevJSym_cv00020	2.31e-121	358.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,1RQ01@1236|Gammaproteobacteria,1J4TK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	norB	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0016966,GO:0055114	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
k59_934519_1	1442599.JAAN01000015_gene3201	1.45e-105	333.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1X45Q@135614|Xanthomonadales	135614|Xanthomonadales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_993784_1	472759.Nhal_0092	1.28e-78	261.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWNH@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1209851_1	1043205.AFYF01000074_gene1956	7.79e-166	475.0	COG3385@1|root,COG3385@2|Bacteria,2GJUG@201174|Actinobacteria	201174|Actinobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_993787_1	261292.Nit79A3_0890	2.04e-44	157.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2VH8Q@28216|Betaproteobacteria,37261@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_1146682_1	1123393.KB891316_gene1230	3.28e-114	339.0	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,2VJ62@28216|Betaproteobacteria,1KSJA@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1619359_1	207559.Dde_1513	1.52e-93	291.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2M88M@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_792727_1	933262.AXAM01000007_gene2042	1.02e-69	228.0	COG1219@1|root,COG1219@2|Bacteria,1MWIZ@1224|Proteobacteria,42N1Z@68525|delta/epsilon subdivisions,2WJUS@28221|Deltaproteobacteria,2MHMD@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the ClpX chaperone family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
k59_993792_1	1449347.JQLN01000007_gene1078	2.51e-47	169.0	COG0366@1|root,COG0366@2|Bacteria,2GIV1@201174|Actinobacteria,2M0NU@2063|Kitasatospora	201174|Actinobacteria	G	Alpha-amylase domain	malL	-	2.4.1.4,3.2.1.1,3.2.1.20,5.4.99.16	ko:K01187,ko:K05341,ko:K05343	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R01557,R01823,R02108,R02112,R06087,R06088,R11262	RC00028,RC00049,RC00077,RC01816	ko00000,ko00001,ko01000	-	GH13,GH31	-	Alpha-amylase,DUF3459
k59_54516_2	314287.GB2207_06378	1.03e-37	130.0	COG4517@1|root,COG4517@2|Bacteria,1MZJX@1224|Proteobacteria,1S95D@1236|Gammaproteobacteria,1J6M4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	IV02_29925	-	-	-	-	-	-	-	-	-	-	-	DUF1820
k59_54516_4	767817.Desgi_0931	1.04e-87	278.0	COG0471@1|root,COG0471@2|Bacteria,1TSP2@1239|Firmicutes,24DU3@186801|Clostridia,26769@186807|Peptococcaceae	186801|Clostridia	P	Similarity to COG0471 Di- and tricarboxylate transporters(Evalue	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
k59_112817_1	590998.Celf_3547	1.32e-50	181.0	COG0577@1|root,COG0577@2|Bacteria,2GJTZ@201174|Actinobacteria,4F1V7@85016|Cellulomonadaceae	201174|Actinobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_934544_1	396588.Tgr7_1915	2.23e-77	245.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,1WVX4@135613|Chromatiales	135613|Chromatiales	I	TIGRFAM acetyl-CoA carboxylase, biotin carboxylase	-	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_153523_1	450851.PHZ_p0200	1.96e-41	149.0	COG1812@1|root,COG1812@2|Bacteria,1QPB9@1224|Proteobacteria,2U1WE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	S-adenosylmethionine synthetase (AdoMet synthetase)	-	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
k59_1561162_2	1273125.Rrhod_1426	1.81e-19	85.9	COG0454@1|root,COG0454@2|Bacteria,2I2VT@201174|Actinobacteria,4G9QQ@85025|Nocardiaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
k59_740413_1	1454004.AW11_00036	4.07e-40	147.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,2VJWM@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Na Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
k59_212707_1	1121405.dsmv_3251	1.73e-73	243.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2MHZG@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
k59_682591_1	870187.Thini_3052	2.94e-38	140.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,1RPTG@1236|Gammaproteobacteria,46219@72273|Thiotrichales	72273|Thiotrichales	F	Pyrimidine nucleoside phosphorylase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
k59_55673_1	1123253.AUBD01000004_gene1056	2.67e-49	165.0	COG0730@1|root,COG0730@2|Bacteria,1MVBS@1224|Proteobacteria,1S62V@1236|Gammaproteobacteria,1X3E6@135614|Xanthomonadales	135614|Xanthomonadales	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_564282_1	1123392.AQWL01000004_gene2579	4.89e-52	169.0	COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,2VQ3T@28216|Betaproteobacteria,1KSM7@119069|Hydrogenophilales	119069|Hydrogenophilales	L	Uracil DNA glycosylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	UDG
k59_857858_1	1249627.D779_0511	5.39e-48	161.0	28HKZ@1|root,2Z7VP@2|Bacteria,1R4QW@1224|Proteobacteria,1RZQX@1236|Gammaproteobacteria,1WX0D@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF3050)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3050
k59_622877_1	713587.THITH_14985	1.65e-18	90.1	COG1270@1|root,COG1270@2|Bacteria,1MURM@1224|Proteobacteria,1RN84@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
k59_994845_1	1267005.KB911257_gene698	2.54e-98	295.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2TRAA@28211|Alphaproteobacteria,3N6FQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1794634_1	1249627.D779_4054	4.47e-95	295.0	COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria,1S06C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Alkaline phosphatase	pafA	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
k59_622883_2	1535287.JP74_03745	7.12e-23	92.8	2AY0M@1|root,31Q26@2|Bacteria,1R3CE@1224|Proteobacteria,2U00F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
k59_113980_1	880072.Desac_1631	1.32e-54	189.0	COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1MVD5@1224|Proteobacteria,42NQY@68525|delta/epsilon subdivisions,2WISG@28221|Deltaproteobacteria,2MQ4V@213462|Syntrophobacterales	28221|Deltaproteobacteria	HP	TIGRFAM molybdenum cofactor synthesis domain	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
k59_935589_1	290512.Paes_2080	4.46e-55	187.0	COG0064@1|root,COG0064@2|Bacteria,1FDNY@1090|Chlorobi	1090|Chlorobi	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_741270_1	765910.MARPU_02975	9.57e-57	187.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RY2H@1236|Gammaproteobacteria,1WX0H@135613|Chromatiales	135613|Chromatiales	GM	epimerase dehydratase	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10
k59_1386108_1	580332.Slit_0535	3.37e-37	138.0	COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,2VQGZ@28216|Betaproteobacteria	28216|Betaproteobacteria	PT	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,cNMP_binding
k59_330116_1	367299.JOEE01000006_gene854	2.52e-98	300.0	COG0477@1|root,COG2814@2|Bacteria,2I2IS@201174|Actinobacteria,4FJZS@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_564314_1	398720.MED217_06656	8.14e-57	194.0	COG3250@1|root,COG3250@2|Bacteria,4NESZ@976|Bacteroidetes,1HXMX@117743|Flavobacteriia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.31	ko:K01195	ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01478,R04979,R07818,R08127,R08260,R10830	RC00055,RC00171,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
k59_564314_2	583355.Caka_2976	4.44e-08	54.7	COG0379@1|root,COG0379@2|Bacteria,46SA1@74201|Verrucomicrobia,3K7P4@414999|Opitutae	414999|Opitutae	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
k59_857885_1	626887.J057_10181	1.65e-62	207.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,464I1@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_0417	Anth_synt_I_N,Chorismate_bind
k59_407560_1	706587.Desti_0714	1.19e-61	199.0	COG0730@1|root,COG0730@2|Bacteria,1Q05R@1224|Proteobacteria,42NT9@68525|delta/epsilon subdivisions,2WJVB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_994895_1	1215092.PA6_046_00230	4.42e-31	124.0	COG3497@1|root,COG3497@2|Bacteria,1MX89@1224|Proteobacteria,1RQUU@1236|Gammaproteobacteria,1YH70@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
k59_857894_1	710696.Intca_0795	1.88e-05	46.6	COG3547@1|root,COG3547@2|Bacteria,2IBF5@201174|Actinobacteria	201174|Actinobacteria	L	Transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_564325_1	1033802.SSPSH_000373	6.43e-81	259.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,1RMHR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2015 Alkyl sulfatase and related hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_1738417_1	367299.JOEE01000004_gene1176	1.09e-100	298.0	COG0390@1|root,COG0390@2|Bacteria,2GMHX@201174|Actinobacteria,4FG19@85021|Intrasporangiaceae	201174|Actinobacteria	S	Uncharacterised protein family (UPF0014)	ybbM	-	-	ko:K02069	-	M00211	-	-	ko00000,ko00002,ko02000	9.B.25.1	-	-	UPF0014
k59_994896_1	713587.THITH_00820	5.85e-103	321.0	COG1205@1|root,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,1S0XD@1236|Gammaproteobacteria,1WXNC@135613|Chromatiales	135613|Chromatiales	L	DEAD DEAH box	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
k59_1799218_1	472759.Nhal_2086	2.7e-113	335.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1WWTH@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
k59_1391163_1	1303518.CCALI_02238	8.28e-65	204.0	COG4122@1|root,COG4122@2|Bacteria	2|Bacteria	E	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24,Methyltransf_3
k59_1282935_1	1049564.TevJSym_ad00270	1.2e-83	263.0	COG1008@1|root,COG1008@2|Bacteria,1R6UV@1224|Proteobacteria,1S0HQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	overlaps another CDS with the same product name	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1035387_1	680646.RMDY18_12660	2.32e-51	173.0	COG0796@1|root,COG0796@2|Bacteria,2GN4I@201174|Actinobacteria,1W8AJ@1268|Micrococcaceae	201174|Actinobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	GO:0000270,GO:0003674,GO:0003824,GO:0004857,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008657,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010911,GO:0016020,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0030234,GO:0032780,GO:0034645,GO:0036361,GO:0042030,GO:0042546,GO:0043086,GO:0043170,GO:0043462,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0047661,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0072586,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:2000371,GO:2000372	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
k59_1035387_2	521393.JH806633_gene1327	5.3e-29	111.0	COG1234@1|root,COG1234@2|Bacteria,2GMEX@201174|Actinobacteria,4D341@85005|Actinomycetales	201174|Actinobacteria	S	Beta-lactamase superfamily domain	yhfI	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_1152132_1	1268237.G114_06567	1.56e-11	65.1	28PFD@1|root,2ZC6I@2|Bacteria,1R8PT@1224|Proteobacteria,1THJU@1236|Gammaproteobacteria,1Y64V@135624|Aeromonadales	135624|Aeromonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_511169_1	765912.Thimo_2579	2.35e-142	418.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1WX2I@135613|Chromatiales	135613|Chromatiales	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
k59_1517156_1	765910.MARPU_01090	3.4e-177	503.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1WWPY@135613|Chromatiales	135613|Chromatiales	I	TIGRFAM acetyl-CoA carboxylase, biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_159486_1	1408473.JHXO01000008_gene2728	1.87e-123	370.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,4NE85@976|Bacteroidetes,2FNPE@200643|Bacteroidia	976|Bacteroidetes	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumB	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
k59_1625151_2	1211114.ALIP01000118_gene2099	1.95e-42	144.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,1S68X@1236|Gammaproteobacteria,1X5XQ@135614|Xanthomonadales	135614|Xanthomonadales	S	EVE domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EVE
k59_797563_1	582899.Hden_2527	7.2e-52	175.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2TSZ3@28211|Alphaproteobacteria,3N6F6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00410,ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
k59_797563_2	717785.HYPMC_0913	9.26e-45	149.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2TTT2@28211|Alphaproteobacteria,3N6V2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
k59_1035405_1	1437882.AZRU01000065_gene6888	1.26e-45	159.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1YDCF@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
k59_1035405_2	1323663.AROI01000007_gene2667	0.000348	43.5	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,1RNXE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
k59_1566951_1	1217718.ALOU01000112_gene4316	1.72e-102	308.0	COG1075@1|root,COG1075@2|Bacteria,1NSK3@1224|Proteobacteria,2WG1G@28216|Betaproteobacteria,1KI8H@119060|Burkholderiaceae	28216|Betaproteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_335769_1	76869.PputGB1_1629	4.79e-26	106.0	2BVHX@1|root,32QW9@2|Bacteria,1REQF@1224|Proteobacteria,1S4VN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_863347_1	1123368.AUIS01000032_gene1398	6.18e-80	262.0	COG0398@1|root,COG1502@1|root,COG0398@2|Bacteria,COG1502@2|Bacteria,1MV8I@1224|Proteobacteria,1RSB6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Pfam SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	PLDc,PLDc_2,SNARE_assoc
k59_1566955_1	335543.Sfum_1228	7.85e-243	700.0	COG0532@1|root,COG3266@1|root,COG0532@2|Bacteria,COG3266@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2MQ8J@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_1035423_1	1133850.SHJG_8840	8.41e-21	95.5	COG5659@1|root,COG5659@2|Bacteria,2GIU9@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_1391200_1	1307759.JOMJ01000003_gene2099	1.9e-37	137.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,42NJT@68525|delta/epsilon subdivisions,2WM7E@28221|Deltaproteobacteria,2MAS7@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	NmrA-like family	dfrA	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	3Beta_HSD,Epimerase
k59_798265_1	358220.C380_22380	6.45e-71	233.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,4AAB5@80864|Comamonadaceae	28216|Betaproteobacteria	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_1284515_1	1385935.N836_18715	1.62e-05	52.8	COG3335@1|root,COG3335@2|Bacteria,1GQVS@1117|Cyanobacteria,1HC3Z@1150|Oscillatoriales	1117|Cyanobacteria	L	Rhodopirellula transposase family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
k59_1284515_2	1306990.BARG01000018_gene1846	1.69e-78	249.0	COG1609@1|root,COG1609@2|Bacteria,2GK7G@201174|Actinobacteria	201174|Actinobacteria	K	Rhodopirellula transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013,HTH_Tnp_4
k59_1452454_1	685778.AORL01000001_gene146	2.49e-26	112.0	COG0726@1|root,COG1215@1|root,COG3858@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,1MXG7@1224|Proteobacteria,2TVZ5@28211|Alphaproteobacteria,2K1ER@204457|Sphingomonadales	204457|Sphingomonadales	GM	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_18,Glyco_tranf_2_3,Polysacc_deac_1
k59_747557_1	312153.Pnuc_1833	3.59e-13	69.3	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2VHNA@28216|Betaproteobacteria,1K09V@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_747557_2	1121937.AUHJ01000004_gene1021	2.39e-18	83.6	COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,468BK@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Modulates RecA activity	recX	GO:0003674,GO:0005488,GO:0005515,GO:0006282,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0048583,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0071496,GO:0080090,GO:0080134,GO:0080135,GO:0098772,GO:2001020	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
k59_1109892_1	1049564.TevJSym_aw00480	7.23e-87	262.0	COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,1RMKJ@1236|Gammaproteobacteria,1J5PK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1284523_2	1306990.BARG01000024_gene2334	5.08e-73	232.0	COG1168@1|root,COG1168@2|Bacteria,2GJFQ@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase, class I	patB	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_570624_2	1304872.JAGC01000009_gene977	1.52e-23	98.6	COG0659@1|root,COG0659@2|Bacteria,1MX1U@1224|Proteobacteria,42QCR@68525|delta/epsilon subdivisions,2WIP7@28221|Deltaproteobacteria,2MGK3@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Molybdate transporter of MFS superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_MOT1
k59_218797_1	1049564.TevJSym_aa01280	2.8e-53	176.0	COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,1S3XK@1236|Gammaproteobacteria,1J6EY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgH	GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464	-	ko:K02393	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgH
k59_688775_1	666685.R2APBS1_1806	9.12e-62	209.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,1RNQ2@1236|Gammaproteobacteria,1X4MS@135614|Xanthomonadales	135614|Xanthomonadales	GM	Multidrug MFS transporter	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
k59_1109903_1	1126627.BAWE01000005_gene6111	2.25e-46	172.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_1109905_1	1163617.SCD_n00027	2.18e-50	171.0	COG5473@1|root,COG5473@2|Bacteria,1PRHB@1224|Proteobacteria,2VTBQ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Predicted integral membrane protein (DUF2189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2189
k59_1518624_1	572477.Alvin_3113	2.67e-70	233.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1WX60@135613|Chromatiales	135613|Chromatiales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_1284555_1	316274.Haur_0623	1.28e-30	122.0	COG1721@1|root,COG1721@2|Bacteria,2G5XH@200795|Chloroflexi,374YS@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k59_688785_2	1389489.O159_24730	2.18e-90	282.0	COG1922@1|root,COG1922@2|Bacteria,2IFW3@201174|Actinobacteria,4FNYS@85023|Microbacteriaceae	201174|Actinobacteria	M	Glycosyl transferase WecB/TagA/CpsF family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_WecB,Glycos_transf_2
k59_1800115_2	1385520.N802_11295	4.84e-63	197.0	COG0251@1|root,COG0251@2|Bacteria,2IHNE@201174|Actinobacteria,4FGP9@85021|Intrasporangiaceae	201174|Actinobacteria	J	LysR family transcriptional regulator	yabJ	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
k59_1800115_3	446471.Xcel_3040	8.36e-29	103.0	2E3JZ@1|root,32YI8@2|Bacteria,2GQIX@201174|Actinobacteria,4F4XK@85017|Promicromonosporaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4177)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4177
k59_570646_1	1283300.ATXB01000001_gene996	1.31e-84	260.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,1T0C4@1236|Gammaproteobacteria,1XEHM@135618|Methylococcales	135618|Methylococcales	C	Radical SAM superfamily	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
k59_160562_2	1158601.I585_04571	1.24e-14	75.9	COG1484@1|root,COG1484@2|Bacteria,1TS3R@1239|Firmicutes,4HDHZ@91061|Bacilli,4B1CK@81852|Enterococcaceae	91061|Bacilli	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_1392282_1	1123261.AXDW01000003_gene1854	2.35e-109	352.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1X465@135614|Xanthomonadales	135614|Xanthomonadales	E	Glutamate synthase	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1392287_1	1265505.ATUG01000002_gene1613	2.95e-54	191.0	COG2204@1|root,COG3829@1|root,COG2204@2|Bacteria,COG3829@2|Bacteria,1MU0N@1224|Proteobacteria,43CWU@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1036560_2	396588.Tgr7_3010	1.27e-64	211.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1WWX1@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_160591_1	471853.Bcav_0837	1.43e-30	110.0	COG4842@1|root,COG4842@2|Bacteria,2GQI8@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the WXG100 family	-	-	-	-	-	-	-	-	-	-	-	-	WXG100
k59_864547_1	795666.MW7_3491	1.64e-102	325.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,1K532@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_336908_1	395963.Bind_0902	1.3e-15	81.6	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2TSWK@28211|Alphaproteobacteria,3NCZ3@45404|Beijerinckiaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_218856_1	1306174.JODP01000001_gene4734	1.9e-135	395.0	COG0436@1|root,COG0436@2|Bacteria,2GJMI@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase	dapC	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k59_747632_1	926569.ANT_21930	2.96e-60	206.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	3.2.1.81,3.2.1.97	ko:K01219,ko:K17624	-	-	-	-	ko00000,ko01000	-	GH101	-	Big_2,CBM_6,Cytochrome_C7,F5_F8_type_C,Glyco_hyd_101C,Glyco_hydro_101,WxL
k59_1153159_1	1232437.KL661971_gene4851	2.68e-68	229.0	COG2864@1|root,COG2864@2|Bacteria,1N5K7@1224|Proteobacteria,42U9M@68525|delta/epsilon subdivisions,2WQ6M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
k59_570689_2	471856.Jden_1522	2.63e-24	108.0	COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria	201174|Actinobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
k59_218861_1	1123392.AQWL01000002_gene1812	4.55e-112	342.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2VH3P@28216|Betaproteobacteria,1KS58@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_218861_2	640081.Dsui_2007	7.95e-40	135.0	COG4327@1|root,COG4327@2|Bacteria,1NQBY@1224|Proteobacteria,2VV4C@28216|Betaproteobacteria,2KXAM@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain of unknown function (DUF4212)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4212
k59_336918_1	261292.Nit79A3_2341	4.09e-13	72.8	COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria,372V5@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	EAL,GGDEF,HAMP,LapD_MoxY_N,PAS,PAS_3,PAS_4,PAS_9
k59_1518695_1	257313.BP2072	6.47e-21	89.4	2C852@1|root,32YB2@2|Bacteria,1RH28@1224|Proteobacteria,2VSQ3@28216|Betaproteobacteria,3T6ZC@506|Alcaligenaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
k59_1626384_1	390989.JOEG01000018_gene3650	5.45e-06	52.8	COG0454@1|root,COG0456@2|Bacteria,2I2W1@201174|Actinobacteria,4DD5J@85008|Micromonosporales	201174|Actinobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,FR47
k59_160618_1	935839.JAGJ01000003_gene1510	9.25e-55	192.0	COG1198@1|root,COG1198@2|Bacteria,2GKES@201174|Actinobacteria,4F3T8@85017|Promicromonosporaceae	201174|Actinobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
k59_1392340_1	1289387.AUKW01000009_gene4432	5.78e-150	438.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria	201174|Actinobacteria	I	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta	accD1	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_798329_1	454957.IA64_17845	2.74e-41	138.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,1S3QK@1236|Gammaproteobacteria,1X6D2@135614|Xanthomonadales	135614|Xanthomonadales	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
k59_798329_2	1249627.D779_3548	9.76e-52	173.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1WWB2@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_570700_2	653733.Selin_0056	2.09e-15	75.5	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	gspH	-	-	ko:K02456,ko:K02457,ko:K02458,ko:K02650	ko02020,ko03070,ko05111,map02020,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	GspH,N_methyl
k59_1392344_2	1173024.KI912152_gene818	4.57e-05	44.3	COG3832@1|root,COG3832@2|Bacteria,1GRIT@1117|Cyanobacteria,1JMJW@1189|Stigonemataceae	1117|Cyanobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
k59_1745244_1	518766.Rmar_0089	3.08e-73	244.0	COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1FIP6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_798331_1	1537917.JU82_10425	1.91e-35	123.0	2CHW3@1|root,32S6N@2|Bacteria,1N0I3@1224|Proteobacteria,42VYX@68525|delta/epsilon subdivisions,2YSCY@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Pathogenicity locus	-	-	-	-	-	-	-	-	-	-	-	-	Cdd1
k59_1110005_1	446466.Cfla_1049	1.79e-111	350.0	COG1012@1|root,COG1454@1|root,COG1012@2|Bacteria,COG1454@2|Bacteria,2GJI2@201174|Actinobacteria,4F0XP@85016|Cellulomonadaceae	201174|Actinobacteria	C	belongs to the iron- containing alcohol dehydrogenase family	adhE	-	1.1.1.1,1.2.1.10,1.2.1.81	ko:K04072,ko:K15515	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	-	R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh,Fe-ADH
k59_336946_1	367299.JOEE01000008_gene551	1.73e-65	204.0	COG1386@1|root,COG1386@2|Bacteria,2GISY@201174|Actinobacteria,4FFUJ@85021|Intrasporangiaceae	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
k59_218892_1	765914.ThisiDRAFT_0659	6.74e-38	141.0	COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,1RP39@1236|Gammaproteobacteria,1X2QU@135613|Chromatiales	135613|Chromatiales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_747680_1	1121952.ATXT01000015_gene244	1.01e-46	159.0	COG1216@1|root,COG1216@2|Bacteria,2I6P4@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyltransferase WbsX	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_WbsX
k59_629662_1	439235.Dalk_5090	1.47e-145	443.0	COG1018@1|root,COG1148@1|root,COG1018@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
k59_1153199_2	1121926.AXWO01000017_gene3087	7.14e-14	70.1	COG0824@1|root,COG0824@2|Bacteria,2IJV6@201174|Actinobacteria	201174|Actinobacteria	S	Thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
k59_1687552_1	344747.PM8797T_12503	5.52e-123	367.0	COG0129@1|root,COG0129@2|Bacteria,2IWXV@203682|Planctomycetes	203682|Planctomycetes	H	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_579125_1	395493.BegalDRAFT_0968	3.81e-24	101.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,46024@72273|Thiotrichales	72273|Thiotrichales	CH	Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	-	-	-	ko:K18800	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04987,R08768	RC00046	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_170969_2	225937.HP15_352	2.09e-12	66.6	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria,464RI@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iSSON_1240.SSON_4131	Semialdhyde_dh,Semialdhyde_dhC
k59_1579302_1	1869.MB27_31535	4.05e-16	78.2	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4DANT@85008|Micromonosporales	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_806161_1	574087.Acear_1158	1.45e-44	157.0	COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,248HB@186801|Clostridia,3WAG6@53433|Halanaerobiales	186801|Clostridia	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
k59_1161731_1	367299.JOEE01000012_gene3253	5e-137	411.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,2GNCW@201174|Actinobacteria,4FENX@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the GcvT family	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
k59_1161731_2	367299.JOEE01000012_gene3252	4.35e-78	239.0	COG2086@1|root,COG2086@2|Bacteria,2IB9F@201174|Actinobacteria,4FIF6@85021|Intrasporangiaceae	201174|Actinobacteria	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_1637085_1	765911.Thivi_2347	1.57e-216	600.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1WXC0@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gapA	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_1637085_2	1266925.JHVX01000007_gene2285	4.16e-05	44.7	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,372XV@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_698118_1	529709.PYCH_06630	2.03e-24	99.8	COG1013@1|root,arCOG01601@2157|Archaea,2XT3E@28890|Euryarchaeota,243A5@183968|Thermococci	183968|Thermococci	C	sulfur compound binding	vorB	-	1.2.7.7	ko:K00187	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C
k59_698118_2	933262.AXAM01000011_gene1756	6.05e-87	268.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,2MJ3H@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_346264_2	452662.SJA_C1-34470	4.88e-47	163.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria,2K0GD@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
k59_346270_1	405948.SACE_6916	1.89e-43	155.0	COG0318@1|root,COG0318@2|Bacteria,2GN9C@201174|Actinobacteria,4DYFK@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	menE	GO:0003674,GO:0003824,GO:0008150,GO:0008756,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0040007	4.2.1.113,6.2.1.26	ko:K01911,ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030,R04031	RC00004,RC00014,RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_757959_2	667015.Bacsa_2452	5.89e-70	229.0	COG0469@1|root,COG0469@2|Bacteria,4NEEU@976|Bacteroidetes,2FNU3@200643|Bacteroidia,4AKUC@815|Bacteroidaceae	976|Bacteroidetes	G	Pyruvate kinase	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_1753866_1	1288298.rosmuc_01225	1.26e-14	73.2	COG0095@1|root,COG0095@2|Bacteria,1N1T8@1224|Proteobacteria,2U1PC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_1753866_2	582899.Hden_0685	3.62e-61	200.0	COG2516@1|root,COG2516@2|Bacteria,1MWZQ@1224|Proteobacteria,2U4HP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Radical SAM	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
k59_757966_1	756272.Plabr_3615	3.03e-22	102.0	COG0004@1|root,COG0784@1|root,COG2198@1|root,COG5002@1|root,COG0004@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG5002@2|Bacteria,2J4Z7@203682|Planctomycetes	203682|Planctomycetes	T	SMART ATP-binding region ATPase domain protein	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,HATPase_c,HisKA,Hpt,PAS_9,Response_reg
k59_806193_1	877418.ATWV01000002_gene1042	5.24e-14	71.2	COG1487@1|root,COG1487@2|Bacteria,2J888@203691|Spirochaetes	203691|Spirochaetes	S	Large family of predicted nucleotide-binding domains	-	-	-	ko:K07062,ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
k59_519312_1	95619.PM1_0210150	4.97e-54	172.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
k59_698151_1	2340.JV46_14830	7.45e-11	65.1	COG1399@1|root,COG1399@2|Bacteria,1PGKW@1224|Proteobacteria,1RRK3@1236|Gammaproteobacteria,1J6U0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	metal-binding, possibly nucleic acid-binding protein	yceD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
k59_638114_1	439497.RR11_3576	1.06e-10	63.2	COG3449@1|root,COG4977@1|root,COG3449@2|Bacteria,COG4977@2|Bacteria,1QTW6@1224|Proteobacteria,2TXDF@28211|Alphaproteobacteria,4NB28@97050|Ruegeria	28211|Alphaproteobacteria	K	Transcriptional regulator, AraC family	-	-	-	ko:K13652	-	-	-	-	ko00000,ko03000	-	-	-	GyrI-like,HTH_18
k59_1579365_1	1049564.TevJSym_bd00010	7.64e-33	124.0	COG3439@1|root,COG3439@2|Bacteria,1RA8I@1224|Proteobacteria,1S34D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_346294_1	1249627.D779_2234	1.07e-58	189.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria,1WY7U@135613|Chromatiales	135613|Chromatiales	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
k59_346294_2	796620.VIBC2010_00560	2.13e-11	63.2	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,1XUB4@135623|Vibrionales	135623|Vibrionales	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
k59_1637127_1	1304865.JAGF01000001_gene3299	4.76e-49	166.0	COG5401@1|root,COG5401@2|Bacteria,2IQ3Y@201174|Actinobacteria	201174|Actinobacteria	S	Immunoglobulin-like domain of bacterial spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad2
k59_757994_1	1454004.AW11_01120	1.89e-33	126.0	COG0055@1|root,COG0055@2|Bacteria,1N6UZ@1224|Proteobacteria,2VI8G@28216|Betaproteobacteria,1KR8G@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	ATP synthase alpha/beta family, nucleotide-binding domain	atpD2	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_757995_1	886293.Sinac_5436	2.2e-65	214.0	COG1057@1|root,COG1057@2|Bacteria,2IYD8@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1402761_1	1121918.ARWE01000001_gene2971	4.45e-140	405.0	COG1363@1|root,COG1363@2|Bacteria,1MWQV@1224|Proteobacteria,42Y9B@68525|delta/epsilon subdivisions	1224|Proteobacteria	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
k59_171056_1	1123057.P872_04760	3.16e-40	155.0	COG3291@1|root,COG5498@1|root,COG3291@2|Bacteria,COG5498@2|Bacteria,4PPR2@976|Bacteroidetes,47YQN@768503|Cytophagia	976|Bacteroidetes	G	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1462371_1	243233.MCA2032	1.46e-103	311.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1XDZ4@135618|Methylococcales	135618|Methylococcales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_1462371_2	713586.KB900536_gene1580	1.54e-83	253.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,1RPK3@1236|Gammaproteobacteria,1WWEP@135613|Chromatiales	135613|Chromatiales	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
k59_1462371_3	1123257.AUFV01000016_gene3534	5.97e-17	79.7	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,1X34R@135614|Xanthomonadales	135614|Xanthomonadales	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_346309_1	471853.Bcav_1602	7.49e-55	193.0	2DBR7@1|root,2ZAIR@2|Bacteria,2IBWI@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_461922_1	706587.Desti_0656	2.11e-12	73.9	COG2010@1|root,COG2010@2|Bacteria,1RJJ2@1224|Proteobacteria,42SCM@68525|delta/epsilon subdivisions,2WPS4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c	pcmF	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_1579403_1	398578.Daci_0755	2.13e-52	179.0	COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2WGKC@28216|Betaproteobacteria,4AASD@80864|Comamonadaceae	28216|Betaproteobacteria	CI	Phosphate acetyl butaryl transferase	pta	-	2.3.1.19,2.3.1.8	ko:K00625,ko:K00634	ko00430,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921,R01174	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas,PTA_PTB
k59_876101_1	590998.Celf_2266	4.33e-119	352.0	COG0331@1|root,COG0331@2|Bacteria,2GME0@201174|Actinobacteria,4F0PZ@85016|Cellulomonadaceae	201174|Actinobacteria	I	Acyl transferase domain	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005835,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
k59_758018_1	1265505.ATUG01000002_gene1171	9.18e-57	200.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,1MWPD@1224|Proteobacteria,434EE@68525|delta/epsilon subdivisions,2WYRT@28221|Deltaproteobacteria,2MN3I@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
k59_806230_1	765910.MARPU_08925	6.13e-78	248.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1WWEZ@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1402790_1	1437824.BN940_02756	3.71e-89	267.0	COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,2VQAQ@28216|Betaproteobacteria,3T3MQ@506|Alcaligenaceae	28216|Betaproteobacteria	J	RNA pseudouridylate synthase	rluE	-	5.4.99.20	ko:K06181	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
k59_1402790_2	1123392.AQWL01000009_gene1138	9.74e-26	99.8	COG1051@1|root,COG1051@2|Bacteria,1N03W@1224|Proteobacteria,2VRC0@28216|Betaproteobacteria,1KT2E@119069|Hydrogenophilales	119069|Hydrogenophilales	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_806239_1	1219035.NT2_06_04290	1.57e-96	292.0	COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2TRKD@28211|Alphaproteobacteria,2K4EX@204457|Sphingomonadales	204457|Sphingomonadales	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_638160_1	765912.Thimo_3328	8.85e-73	243.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1WWJI@135613|Chromatiales	135613|Chromatiales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_519353_1	1132855.KB913035_gene1770	5.49e-59	195.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k59_171098_1	1122223.KB890697_gene1079	3.34e-15	79.3	COG2199@1|root,COG3903@1|root,COG3706@2|Bacteria,COG3903@2|Bacteria	2|Bacteria	K	ADP binding	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	AAA_22,BTAD,GGDEF,Guanylate_cyc,NB-ARC,Pkinase,TPR_12,Trans_reg_C
k59_698214_1	977880.RALTA_A1575	4.39e-10	58.2	COG1006@1|root,COG1006@2|Bacteria,1RH8H@1224|Proteobacteria,2VSVU@28216|Betaproteobacteria,1K8RC@119060|Burkholderiaceae	28216|Betaproteobacteria	P	H antiporter	mnhC1	-	-	ko:K05560	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	Oxidored_q2
k59_698214_2	977880.RALTA_A1574	9.89e-37	138.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2VH1Y@28216|Betaproteobacteria,1K57M@119060|Burkholderiaceae	28216|Betaproteobacteria	CP	Proton-conducting membrane transporter	mnhD	-	-	ko:K05561	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	Proton_antipo_M
k59_1402815_1	472759.Nhal_0023	4.53e-83	261.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1WVY6@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
k59_876132_1	990285.RGCCGE502_16360	7.11e-60	191.0	COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,2UA0Y@28211|Alphaproteobacteria,4B7VB@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	HupE / UreJ protein	hupE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03192	-	-	-	-	ko00000	-	-	-	HupE_UreJ
k59_579236_1	1249627.D779_4134	9.61e-129	390.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales	135613|Chromatiales	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_1049023_1	1123400.KB904768_gene3408	3.75e-211	611.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,461JN@72273|Thiotrichales	72273|Thiotrichales	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1698157_1	243233.MCA0512	1.14e-111	354.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,1XEJM@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0753 family	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k59_1637184_1	446466.Cfla_0578	9.46e-145	442.0	28HKI@1|root,2Z7VC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_519367_1	1232437.KL662077_gene1955	4.43e-61	211.0	COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MIWX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CoA-binding domain protein	acs	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1698163_1	933262.AXAM01000017_gene3121	8.56e-66	209.0	COG0500@1|root,COG2226@2|Bacteria,1RASQ@1224|Proteobacteria,42QTY@68525|delta/epsilon subdivisions,2WMN2@28221|Deltaproteobacteria,2MJIY@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_1698170_1	397945.Aave_4540	8.28e-07	52.0	COG3135@1|root,COG3135@2|Bacteria,1MUS1@1224|Proteobacteria,2VIN0@28216|Betaproteobacteria,4ABDM@80864|Comamonadaceae	28216|Betaproteobacteria	Q	PFAM Benzoate membrane transport protein	benE	-	-	ko:K05782	-	-	-	-	ko00000,ko02000	2.A.46.1	-	-	BenE
k59_1698170_2	504832.OCAR_5303	7.14e-43	149.0	COG1893@1|root,COG1893@2|Bacteria,1QMH8@1224|Proteobacteria,2TSGW@28211|Alphaproteobacteria,3JWCH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_171132_3	118005.AWNK01000007_gene561	3.82e-17	80.9	COG3149@1|root,COG3149@2|Bacteria	2|Bacteria	U	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins	mshJ	-	-	ko:K02462,ko:K12280	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSM
k59_638196_2	768671.ThimaDRAFT_1188	1.52e-55	185.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,1RMYQ@1236|Gammaproteobacteria,1WXFV@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
k59_1049056_1	558169.AGAV01000007_gene1391	1.15e-37	143.0	COG0303@1|root,COG0303@2|Bacteria,1TQJ8@1239|Firmicutes,4HAFT@91061|Bacilli	91061|Bacilli	H	Molybdopterin	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
k59_1579491_1	1454010.JEOE01000011_gene2396	6.49e-53	188.0	COG4425@1|root,COG4425@2|Bacteria,2IBWT@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta-hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_9,Abhydrolase_9_N
k59_806275_1	1049564.TevJSym_am00080	4.09e-91	275.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1J5E4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0004042,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016407,GO:0016410,GO:0016597,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0033554,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.7.2.8	ko:K00930,ko:K22478	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00259,R02649	RC00002,RC00004,RC00043,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_2508,iB21_1397.B21_03793,iEC55989_1330.EC55989_4441,iECB_1328.ECB_03844,iECDH10B_1368.ECDH10B_4147,iECDH1ME8569_1439.ECDH1ME8569_3827,iECD_1391.ECD_03844,iECH74115_1262.ECH74115_5419,iECIAI1_1343.ECIAI1_4167,iECO103_1326.ECO103_4715,iECOK1_1307.ECOK1_4431,iECS88_1305.ECS88_4414,iECSE_1348.ECSE_4252,iETEC_1333.ETEC_4227,iEcE24377_1341.EcE24377A_4498,iEcHS_1320.EcHS_A4193,iEcolC_1368.EcolC_4057,iSbBS512_1146.SbBS512_E4445,iUMN146_1321.UM146_20050,iUMNK88_1353.UMNK88_4797,iUTI89_1310.UTI89_C4550,iY75_1357.Y75_RS17255	AA_kinase,NAT
k59_1753970_1	1366050.N234_03155	3.76e-52	181.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VJI5@28216|Betaproteobacteria,1K2DS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1049058_1	883078.HMPREF9695_01781	7.47e-36	138.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2TRS4@28211|Alphaproteobacteria,3JUHV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	glycosyl transferase, family 39	MA20_30100	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
k59_1227929_1	1246459.KB898378_gene3466	7.34e-53	174.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,2U7FV@28211|Alphaproteobacteria,4B87C@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
k59_1699947_1	1049564.TevJSym_ay00370	5.96e-88	285.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1J4SF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_878121_1	582899.Hden_0635	2.11e-98	298.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,2TSTM@28211|Alphaproteobacteria,3N6DW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Amidohydrolase family	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_699848_1	1163617.SCD_n01160	9.83e-313	871.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Extracellular solute-binding protein	oppA	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
k59_1581275_1	519989.ECTPHS_00350	2.57e-40	146.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,1WWCY@135613|Chromatiales	135613|Chromatiales	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_1229725_1	1390370.O203_16175	5.11e-130	390.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria,1YDVB@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	fadH	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
k59_1463809_1	631362.Thi970DRAFT_04971	7.13e-95	285.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,1RMK2@1236|Gammaproteobacteria,1WX2M@135613|Chromatiales	135613|Chromatiales	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_1699970_1	926550.CLDAP_19660	5.88e-87	266.0	COG1172@1|root,COG1172@2|Bacteria,2G6A4@200795|Chloroflexi	200795|Chloroflexi	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
k59_1755469_1	1121403.AUCV01000031_gene2857	7.02e-40	147.0	29GCA@1|root,303A5@2|Bacteria,1NC46@1224|Proteobacteria,431AV@68525|delta/epsilon subdivisions,2WWN5@28221|Deltaproteobacteria,2MNY5@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_230738_1	266835.14025888	3.63e-32	114.0	COG2963@1|root,COG2963@2|Bacteria,1N2T5@1224|Proteobacteria,2U9CF@28211|Alphaproteobacteria,43PQB@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_230738_2	864051.BurJ1DRAFT_3279	4.66e-75	232.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VQF1@28216|Betaproteobacteria,1KPGZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_1755474_1	205922.Pfl01_4307	3.29e-13	78.6	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1RPR0@1236|Gammaproteobacteria,1YNI9@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	T	MASE2 domain	adrA	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0052621	2.7.7.65	ko:K18968	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000,ko02000	9.B.34.1.2	-	iECSF_1327.ECSF_0346,ic_1306.c0492	GGDEF,MASE2
k59_1404679_1	1267005.KB911260_gene3578	2.77e-86	278.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,2TRGN@28211|Alphaproteobacteria,3N651@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_348084_1	990285.RGCCGE502_07434	1.31e-71	239.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2TRHV@28211|Alphaproteobacteria,4B8ZF@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1700002_1	642492.Clole_2420	4.35e-15	75.1	COG0750@1|root,COG0750@2|Bacteria,1TPMC@1239|Firmicutes,247MT@186801|Clostridia	186801|Clostridia	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_1700002_2	1042376.AFPK01000013_gene37	6.59e-13	68.9	COG4589@1|root,COG4589@2|Bacteria,4NIPM@976|Bacteroidetes,1HXPT@117743|Flavobacteriia,406ET@61432|unclassified Flavobacteriaceae	976|Bacteroidetes	S	Cytidylyltransferase family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
k59_520548_1	1304865.JAGF01000001_gene439	1.81e-172	507.0	COG0515@1|root,COG0515@2|Bacteria,2GJ24@201174|Actinobacteria,4F1RI@85016|Cellulomonadaceae	201174|Actinobacteria	KLT	Protein kinase G tetratricopeptide repeat	pknG	-	2.7.11.1	ko:K14949	ko05152,map05152	-	-	-	ko00000,ko00001,ko01000,ko01001	-	-	-	Pkinase,PknG_TPR,PknG_rubred
k59_412741_1	590998.Celf_0936	3.53e-112	334.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4F0IM@85016|Cellulomonadaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_1586699_1	754476.Q7A_747	6.07e-87	270.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,46060@72273|Thiotrichales	72273|Thiotrichales	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	mltF	-	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
k59_471518_1	314254.OA2633_13560	1.32e-51	172.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2TRBW@28211|Alphaproteobacteria,43WV7@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_471518_2	189426.PODO_06100	8.32e-09	57.8	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,4H9R8@91061|Bacilli,26STM@186822|Paenibacillaceae	91061|Bacilli	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfA	-	-	ko:K16786	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
k59_61752_1	1304883.KI912532_gene1528	3.09e-53	175.0	COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2VHU3@28216|Betaproteobacteria,2KUX6@206389|Rhodocyclales	206389|Rhodocyclales	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
k59_61752_2	1304883.KI912532_gene1529	1.69e-29	114.0	COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2VN6W@28216|Betaproteobacteria,2KVGJ@206389|Rhodocyclales	206389|Rhodocyclales	M	Glycosyltransferase Family 4	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_706386_1	469371.Tbis_3360	3.14e-26	104.0	COG4315@1|root,COG4315@2|Bacteria,2GNDV@201174|Actinobacteria,4E3F9@85010|Pseudonocardiales	201174|Actinobacteria	S	Secreted repeat of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
k59_530284_1	1123368.AUIS01000002_gene1534	2.43e-105	338.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,2NBY2@225057|Acidithiobacillales	225057|Acidithiobacillales	C	Domain of unknown function (DUF3400)	-	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_999810_1	1122947.FR7_4048	2.17e-54	183.0	COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,4H2A6@909932|Negativicutes	909932|Negativicutes	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k59_1176019_1	1479237.JMLY01000001_gene3107	2.18e-86	278.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,464Q5@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_412751_1	471853.Bcav_2160	4.4e-114	335.0	COG0109@1|root,COG0109@2|Bacteria,2GJMY@201174|Actinobacteria	201174|Actinobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_412751_2	1713.JOFV01000015_gene1782	7.12e-42	148.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4F0ZS@85016|Cellulomonadaceae	201174|Actinobacteria	L	integrase domain protein SAM domain protein	xerD	GO:0008150,GO:0040007	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_883619_1	1538295.JY96_01315	5.44e-23	95.9	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2VI2C@28216|Betaproteobacteria,1KIW3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_883619_2	765912.Thimo_2526	1.68e-138	396.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,1RNUF@1236|Gammaproteobacteria,1WWM1@135613|Chromatiales	135613|Chromatiales	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_706394_1	648757.Rvan_0850	7.63e-59	197.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TUX3@28211|Alphaproteobacteria,3N645@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_61766_1	1120945.ATUW01000006_gene772	4.46e-85	266.0	COG0366@1|root,COG0366@2|Bacteria,2GNEC@201174|Actinobacteria,4D58G@85005|Actinomycetales	201174|Actinobacteria	G	Alpha amylase, catalytic domain	gtfA	-	2.4.1.7	ko:K00690	ko00500,map00500	-	R00803	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF1964
k59_1117205_1	338963.Pcar_0385	1.36e-16	80.5	COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,43BJ2@68525|delta/epsilon subdivisions,2X75C@28221|Deltaproteobacteria,43UGU@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Secretin N-terminal domain	-	-	-	ko:K02453,ko:K12282	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N_2
k59_1117205_2	1515746.HR45_08140	1.61e-110	329.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,2Q9UU@267890|Shewanellaceae	1236|Gammaproteobacteria	U	AAA domain	mshM	-	-	ko:K12283	-	-	-	-	ko00000,ko02044	-	-	-	AAA_22
k59_61769_1	675813.VIB_001646	9.44e-23	96.7	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria,1XU10@135623|Vibrionales	135623|Vibrionales	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_61769_2	522306.CAP2UW1_4428	4.38e-34	126.0	COG1397@1|root,COG1397@2|Bacteria,1NTUR@1224|Proteobacteria,2VM8T@28216|Betaproteobacteria	28216|Betaproteobacteria	O	ADP-ribosyl- dinitrogen reductase hydrolase	draG	-	3.2.2.24	ko:K05521	-	-	-	-	ko00000,ko01000	-	-	-	ADP_ribosyl_GH
k59_412758_2	926569.ANT_03790	9.75e-46	156.0	COG0463@1|root,COG0463@2|Bacteria,2GBP0@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
k59_2598_1	420324.KI912013_gene9358	1.76e-45	159.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2TT6H@28211|Alphaproteobacteria,1JRS3@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_999820_1	980584.AFPB01000133_gene3066	0.000242	45.8	COG2114@1|root,COG2114@2|Bacteria,4NMKB@976|Bacteroidetes,1IJ5A@117743|Flavobacteriia	976|Bacteroidetes	T	Protein of unknown function (DUF2652)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2652
k59_1234773_2	710696.Intca_1501	1.61e-22	94.0	COG3339@1|root,COG3339@2|Bacteria,2GQGT@201174|Actinobacteria,4FHX1@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
k59_647707_1	156889.Mmc1_1697	1.99e-70	226.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,2TU0C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0471 Di- and tricarboxylate transporters	-	-	-	ko:K03319,ko:K09477,ko:K11106,ko:K14445	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.47,2.A.47.1,2.A.47.3.2,2.A.47.3.3	-	-	Na_sulph_symp
k59_355227_2	1165096.ARWF01000001_gene1923	9.7e-17	77.4	COG3212@1|root,COG3212@2|Bacteria,1NHDB@1224|Proteobacteria,2VWE0@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Propeptide PepSY amd peptidase M4	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
k59_355227_3	338969.Rfer_0744	0.000199	43.1	COG3658@1|root,COG3658@2|Bacteria,1RB03@1224|Proteobacteria,2VQQ7@28216|Betaproteobacteria,4AJE0@80864|Comamonadaceae	28216|Betaproteobacteria	C	Cytochrome b/b6/petB	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_1411543_1	876044.IMCC3088_2039	1.05e-60	197.0	COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,1RR3K@1236|Gammaproteobacteria,1J5HN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG2111 Multisubunit Na H antiporter, MnhB subunit	-	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB
k59_1411543_2	318167.Sfri_2285	2.2e-21	87.0	COG1006@1|root,COG1006@2|Bacteria,1RGU1@1224|Proteobacteria,1S6BB@1236|Gammaproteobacteria,2QC1C@267890|Shewanellaceae	1236|Gammaproteobacteria	P	PFAM NADH-ubiquinone oxidoreductase chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
k59_1295609_1	316056.RPC_1308	7.82e-22	99.0	COG2204@1|root,COG2204@2|Bacteria,1R6SD@1224|Proteobacteria,2TUZC@28211|Alphaproteobacteria,3JX3J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Transcriptional regulator	ppsR2	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_8
k59_1823817_1	314285.KT71_00505	3.72e-77	246.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria,1J7QW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
k59_1528784_1	675812.VHA_000705	1.56e-177	513.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1XSX1@135623|Vibrionales	135623|Vibrionales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tktA	GO:0003674,GO:0003824,GO:0004802,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009987,GO:0016740,GO:0016744,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_765516_1	396588.Tgr7_3071	1.56e-87	268.0	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,1RMFS@1236|Gammaproteobacteria,1WWVD@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
k59_1295620_1	768671.ThimaDRAFT_2293	4.15e-136	392.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1WXAY@135613|Chromatiales	135613|Chromatiales	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_62821_1	164757.Mjls_5233	3.8e-74	249.0	COG0479@1|root,COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0479@2|Bacteria,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2I995@201174|Actinobacteria,237Z9@1762|Mycobacteriaceae	201174|Actinobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_62822_1	1121405.dsmv_3691	1.66e-86	265.0	COG3547@1|root,COG3547@2|Bacteria,1NP2U@1224|Proteobacteria,43A5Q@68525|delta/epsilon subdivisions,2X2AM@28221|Deltaproteobacteria,2MPDW@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1470218_1	1127134.NOCYR_2973	1.49e-114	341.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4FUUY@85025|Nocardiaceae	201174|Actinobacteria	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1352818_1	1238182.C882_0579	8.68e-84	268.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2JPYX@204441|Rhodospirillales	204441|Rhodospirillales	I	COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit	-	-	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_1117805_1	1123401.JHYQ01000013_gene613	2.05e-06	48.5	COG0830@1|root,COG0830@2|Bacteria,1MW8Q@1224|Proteobacteria,1RP91@1236|Gammaproteobacteria,460WI@72273|Thiotrichales	72273|Thiotrichales	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureF	-	-	ko:K03188	-	-	-	-	ko00000	-	-	-	UreF
k59_1117805_2	765913.ThidrDRAFT_2233	9.63e-124	355.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RP5R@1236|Gammaproteobacteria,1WXS2@135613|Chromatiales	135613|Chromatiales	KO	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG	ureG	-	-	ko:K03189	-	-	-	-	ko00000	-	-	-	cobW
k59_1235500_1	933262.AXAM01000002_gene553	1.98e-47	169.0	COG4191@1|root,COG4191@2|Bacteria,1R7KQ@1224|Proteobacteria,42PAP@68525|delta/epsilon subdivisions,2WITB@28221|Deltaproteobacteria,2MHP3@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,dCache_1
k59_943428_1	706587.Desti_0760	6.85e-127	377.0	COG0025@1|root,COG0025@2|Bacteria,1REWR@1224|Proteobacteria,437JE@68525|delta/epsilon subdivisions,2X2TE@28221|Deltaproteobacteria,2MQZ0@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_120141_1	1242864.D187_002372	3.72e-73	234.0	COG4143@1|root,COG4143@2|Bacteria,1R4IE@1224|Proteobacteria,42QHK@68525|delta/epsilon subdivisions,2WUK2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	(ABC) transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_472275_1	1267005.KB911255_gene2537	6.17e-110	334.0	2C20F@1|root,32R9J@2|Bacteria,1RKQ3@1224|Proteobacteria	1224|Proteobacteria	S	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C92
k59_1295645_1	519989.ECTPHS_10616	7.26e-77	239.0	COG0300@1|root,COG0300@2|Bacteria,1R735@1224|Proteobacteria,1RSHH@1236|Gammaproteobacteria,1WZ0W@135613|Chromatiales	135613|Chromatiales	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_356315_2	744979.R2A130_1298	1.52e-15	68.9	COG0257@1|root,COG0257@2|Bacteria,1NGBJ@1224|Proteobacteria,2UJAG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
k59_943442_1	1317124.DW2_11611	1.93e-25	109.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2TSJN@28211|Alphaproteobacteria,2XMEA@285107|Thioclava	28211|Alphaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C
k59_943442_2	338966.Ppro_1766	2.01e-12	66.2	COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,42N7S@68525|delta/epsilon subdivisions,2WMBC@28221|Deltaproteobacteria,43SAE@69541|Desulfuromonadales	28221|Deltaproteobacteria	MU	SMART AAA ATPase	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
k59_178770_1	1158756.AQXQ01000012_gene1473	6.37e-29	115.0	COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,1RNXP@1236|Gammaproteobacteria,1WX7Y@135613|Chromatiales	135613|Chromatiales	HJ	Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3,RLAN,RimK
k59_178770_2	396588.Tgr7_3067	1.59e-47	160.0	COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,1RR95@1236|Gammaproteobacteria,1WVUK@135613|Chromatiales	135613|Chromatiales	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
k59_1235513_1	270374.MELB17_19786	8.65e-14	71.2	COG1752@1|root,COG1752@2|Bacteria,1R7RX@1224|Proteobacteria,1RRTH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_1235513_2	1396858.Q666_00745	2.19e-22	95.1	COG3937@1|root,COG3937@2|Bacteria,1N7X8@1224|Proteobacteria,1T08C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Polyhydroxyalkanoate granule-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
k59_1235513_3	998088.B565_1980	5.79e-26	104.0	2AYXV@1|root,31R3M@2|Bacteria,1RHPG@1224|Proteobacteria,1SYAS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_884735_1	1049564.TevJSym_cb00050	4.36e-45	166.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1J6D9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin,Thioredoxin_7
k59_3548_1	1304865.JAGF01000001_gene2261	7.35e-88	271.0	COG2723@1|root,COG2723@2|Bacteria,2GJAF@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 1 family	bglH	-	3.2.1.86	ko:K01223	ko00010,ko00500,map00010,map00500	-	R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000	-	GT1	-	Glyco_hydro_1
k59_1528827_1	1313301.AUGC01000007_gene596	8.96e-18	83.2	COG0045@1|root,COG0045@2|Bacteria,4NFHA@976|Bacteroidetes	976|Bacteroidetes	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_1528827_2	402881.Plav_2661	1.84e-05	49.7	COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,2TW0S@28211|Alphaproteobacteria,1JP8I@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_943469_1	220664.PFL_2226	5.34e-37	142.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RYYQ@1236|Gammaproteobacteria,1YP2W@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_8,PAS_9,Response_reg
k59_1411591_1	1121438.JNJA01000002_gene3585	6.25e-19	84.0	2E46A@1|root,32Z28@2|Bacteria,1N6V5@1224|Proteobacteria,43BFN@68525|delta/epsilon subdivisions,2X6U2@28221|Deltaproteobacteria,2MH6X@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_62881_1	1230476.C207_05549	1.93e-181	525.0	COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,2TT84@28211|Alphaproteobacteria,3JTYR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0061 (SELO) family	MA20_28420	-	-	ko:K08997	-	-	-	-	ko00000	-	-	-	UPF0061
k59_356362_1	269798.CHU_1054	3.44e-78	248.0	COG3046@1|root,COG3046@2|Bacteria,4NECD@976|Bacteroidetes,47N6N@768503|Cytophagia	976|Bacteroidetes	S	Deoxyribodipyrimidine photo-lyase-related protein	-	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP,FAD_binding_7
k59_1295696_1	670487.Ocepr_1323	1.98e-22	101.0	COG2074@1|root,COG2074@2|Bacteria,1WI2U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	2-phosphoglycerate kinase	-	-	-	ko:K05715	-	-	R02664	RC00002,RC00017	ko00000,ko01000	-	-	-	AAA_33,ATP-cone
k59_1000464_1	572477.Alvin_2889	3.64e-100	302.0	COG0552@1|root,COG3087@1|root,COG0552@2|Bacteria,COG3087@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,1WW5G@135613|Chromatiales	135613|Chromatiales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
k59_1587444_1	1499967.BAYZ01000154_gene1465	1.35e-39	149.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	fucI	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006004,GO:0008150,GO:0008152,GO:0008736,GO:0008790,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019317,GO:0019318,GO:0019320,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019571,GO:0042354,GO:0042355,GO:0042802,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0046372,GO:0071704,GO:1901575	5.3.1.25,5.3.1.3	ko:K01818	ko00051,ko01120,map00051,map01120	-	R03163	RC00434	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c30720,ic_1306.c3371	Fucose_iso_C,Fucose_iso_N1,Fucose_iso_N2
k59_296294_1	519989.ECTPHS_08271	2.74e-97	300.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1WVVK@135613|Chromatiales	135613|Chromatiales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_413484_1	1121405.dsmv_0342	4.38e-98	299.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42M1W@68525|delta/epsilon subdivisions,2WK53@28221|Deltaproteobacteria,2MIJV@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_648439_1	941449.dsx2_2178	1.53e-74	238.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2M833@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	nuoF-2	-	1.12.1.3,1.6.5.3	ko:K00334,ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k59_356379_1	768671.ThimaDRAFT_0177	2.26e-97	291.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,1WVUX@135613|Chromatiales	135613|Chromatiales	M	Lipid A biosynthesis	lpxL	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_1823919_1	356851.JOAN01000014_gene1985	2.91e-92	286.0	2BK7D@1|root,32EM6@2|Bacteria,2HBWP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1235547_1	768671.ThimaDRAFT_2107	5.64e-61	192.0	2E61I@1|root,2ZBKY@2|Bacteria,1R3IR@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1646648_2	489825.LYNGBM3L_21190	2.89e-58	191.0	COG0438@1|root,COG0438@2|Bacteria,1GC2Y@1117|Cyanobacteria	1117|Cyanobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1059710_1	340177.Cag_0616	1.43e-32	133.0	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Big_3_2,CHU_C,Flg_new,LRR_5
k59_1000468_2	1255043.TVNIR_1306	3.66e-91	287.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	ybbN	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_1352882_1	1411123.JQNH01000001_gene654	5.95e-92	288.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TQWP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	gamma-glutamyltransferase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1176848_1	331678.Cphamn1_1201	1.71e-70	234.0	COG1883@1|root,COG1883@2|Bacteria,1FEQK@1090|Chlorobi	1090|Chlorobi	C	PFAM Na transporting methylmalonyl-CoA oxaloacetate decarboxylase beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
k59_1176848_2	1121451.DESAM_20125	3.8e-111	343.0	COG4770@1|root,COG5016@1|root,COG4770@2|Bacteria,COG5016@2|Bacteria,1R5RS@1224|Proteobacteria,42M3K@68525|delta/epsilon subdivisions,2X9QA@28221|Deltaproteobacteria,2M9XQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	CI	Conserved carboxylase domain	-	-	6.4.1.1	ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_178827_1	742723.HMPREF9477_01900	4.33e-18	89.7	COG2866@1|root,COG2866@2|Bacteria,1TSIY@1239|Firmicutes,249Z5@186801|Clostridia,27RRA@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
k59_237907_1	768671.ThimaDRAFT_2335	5.47e-33	122.0	2E3CB@1|root,32YBM@2|Bacteria,1N6WD@1224|Proteobacteria,1S4J5@1236|Gammaproteobacteria,1WY7R@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4154)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4154
k59_1478414_1	935863.AWZR01000006_gene1350	3.74e-49	178.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1X4J8@135614|Xanthomonadales	135614|Xanthomonadales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1358816_2	935845.JADQ01000025_gene361	8.44e-10	59.3	COG1101@1|root,COG1101@2|Bacteria,1TPAN@1239|Firmicutes,4HCHC@91061|Bacilli,26TB7@186822|Paenibacillaceae	91061|Bacilli	S	ABC transporter, ATP-binding protein	-	-	-	ko:K05833	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
k59_1358816_3	67352.JODS01000003_gene2140	2.06e-12	68.2	COG1506@1|root,COG1506@2|Bacteria,2GJW4@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase S9 prolyl oligopeptidase active site domain protein	-	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S9
k59_1769280_1	105559.Nwat_0233	1.57e-46	163.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1WXJ6@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_1418216_1	590998.Celf_0730	2.61e-136	397.0	COG1004@1|root,COG1004@2|Bacteria,2GJQB@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	rkpK	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
k59_713471_1	1313172.YM304_24190	4.19e-75	243.0	COG1199@1|root,COG1199@2|Bacteria,2GKT8@201174|Actinobacteria	201174|Actinobacteria	KL	helicase	dinG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
k59_14449_1	446466.Cfla_2397	5.09e-10	59.3	COG3920@1|root,COG3920@2|Bacteria,2GKMP@201174|Actinobacteria,4F1Y3@85016|Cellulomonadaceae	201174|Actinobacteria	T	SMART ATP-binding region ATPase domain protein	pdtaS	GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K00936	-	M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,H_kinase_N,HisKA_2,PAS_4
k59_14449_2	471853.Bcav_2830	3.09e-44	150.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2505
k59_1304527_1	876269.ARWA01000001_gene1160	9.15e-54	191.0	COG0457@1|root,COG2227@1|root,COG3914@1|root,COG0457@2|Bacteria,COG2227@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,3NAKJ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	HO	Glycosyl transferase family 41	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,Methyltransf_23,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
k59_1067887_1	305700.B447_20795	4.47e-06	47.4	COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,2VVQK@28216|Betaproteobacteria,2KX0P@206389|Rhodocyclales	206389|Rhodocyclales	KL	Belongs to the transcriptional regulatory Fis family	-	-	-	ko:K03557	ko05111,map05111	-	-	-	ko00000,ko00001,ko03000,ko03036,ko03400	-	-	-	HTH_8
k59_1067887_2	1123253.AUBD01000005_gene140	2.01e-17	81.6	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria,1X3G9@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_1418224_1	675812.VHA_001341	8.47e-55	189.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,1XVNX@135623|Vibrionales	135623|Vibrionales	M	Small-conductance mechanosensitive channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel
k59_1653018_1	1043205.AFYF01000074_gene1956	2.18e-37	137.0	COG3385@1|root,COG3385@2|Bacteria,2GJUG@201174|Actinobacteria	201174|Actinobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_1478433_1	1260251.SPISAL_00290	4.18e-08	55.1	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1WVWG@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
k59_537224_1	367299.JOEE01000002_gene2615	2.69e-61	196.0	COG3879@1|root,COG3879@2|Bacteria,2GJ9Y@201174|Actinobacteria,4FFV4@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF881)	-	-	-	-	-	-	-	-	-	-	-	-	DUF881
k59_537224_2	446466.Cfla_0022	8.62e-08	53.9	COG3764@1|root,COG3764@2|Bacteria,2GKT6@201174|Actinobacteria,4F1CV@85016|Cellulomonadaceae	201174|Actinobacteria	M	PFAM peptidase C60 sortase A and B	srtB	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
k59_713481_1	471853.Bcav_0565	1.72e-105	323.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GJW4@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase S9 prolyl oligopeptidase active site domain protein	-	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S9
k59_1304543_1	395493.BegalDRAFT_2838	7.61e-42	139.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,46133@72273|Thiotrichales	72273|Thiotrichales	J	Sigma 54 modulation protein	yhbH	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
k59_1304543_2	1165096.ARWF01000001_gene1402	1.67e-12	69.7	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2VJCH@28216|Betaproteobacteria,2KKT6@206350|Nitrosomonadales	206350|Nitrosomonadales	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
k59_185200_1	760192.Halhy_2938	3.31e-82	257.0	COG1350@1|root,COG1350@2|Bacteria,4PKSY@976|Bacteroidetes,1IVN5@117747|Sphingobacteriia	976|Bacteroidetes	E	Pyridoxal-phosphate dependent enzyme	trpB	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_537230_1	992406.RIA_1467	6.18e-49	163.0	COG0479@1|root,COG0479@2|Bacteria,4NFR3@976|Bacteroidetes,1HYVV@117743|Flavobacteriia	976|Bacteroidetes	C	Succinate dehydrogenase fumarate reductase Fe-S protein subunit	frdB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
k59_537230_2	1150864.MILUP08_42273	2.85e-30	120.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4DB6C@85008|Micromonosporales	201174|Actinobacteria	C	fumarate reductase, flavoprotein subunit	sdhA	-	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1710862_1	472759.Nhal_2328	7.04e-93	280.0	COG4787@1|root,COG4787@2|Bacteria,1NZWQ@1224|Proteobacteria,1RNVX@1236|Gammaproteobacteria,1WWVR@135613|Chromatiales	135613|Chromatiales	N	TIGRFAM flagellar basal-body rod protein FlgF	-	-	-	ko:K02391	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
k59_1653027_2	1286631.X805_21290	6.5e-64	206.0	COG0775@1|root,COG0775@2|Bacteria,1MY5S@1224|Proteobacteria,2VQBX@28216|Betaproteobacteria,1KKNE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	mtnN	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
k59_14487_1	506534.Rhein_3597	5.24e-62	214.0	COG1629@1|root,COG1629@2|Bacteria,1MX4K@1224|Proteobacteria,1RP6B@1236|Gammaproteobacteria,1X0CV@135613|Chromatiales	135613|Chromatiales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_830648_1	32057.KB217478_gene545	1.29e-106	315.0	COG2321@1|root,COG2321@2|Bacteria,1G20J@1117|Cyanobacteria,1HRR5@1161|Nostocales	1117|Cyanobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
k59_1067914_1	1415780.JPOG01000001_gene894	9.94e-86	265.0	COG0108@1|root,COG0108@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1X31N@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_713491_1	644282.Deba_0563	1.39e-08	55.5	2CDHP@1|root,32RXU@2|Bacteria,1N1BP@1224|Proteobacteria,42TPT@68525|delta/epsilon subdivisions,2WQE6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	RsbT co-antagonist protein rsbRD N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RsbRD_N
k59_893345_1	344747.PM8797T_25576	1.07e-28	115.0	COG0841@1|root,COG0841@2|Bacteria,2IY0K@203682|Planctomycetes	203682|Planctomycetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_893345_2	1121441.AUCX01000014_gene561	1.63e-13	72.4	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42NTQ@68525|delta/epsilon subdivisions,2WITY@28221|Deltaproteobacteria,2M8YW@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	PFAM peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
k59_1183237_2	1267005.KB911259_gene3759	3.83e-52	172.0	COG0616@1|root,COG0616@2|Bacteria,1MY1I@1224|Proteobacteria,2U07G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	OU	Serine dehydrogenase proteinase	-	-	-	-	-	-	-	-	-	-	-	-	SDH_sah
k59_893347_1	316067.Geob_3816	5.85e-46	170.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,43TJB@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM glycosyl transferase family 51	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
k59_185205_1	588932.JHOF01000024_gene38	1.28e-118	353.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TW14@28211|Alphaproteobacteria,2KI3M@204458|Caulobacterales	204458|Caulobacterales	E	Cys/Met metabolism PLP-dependent enzyme	-	-	4.4.1.11	ko:K01761	ko00270,ko00450,map00270,map00450	-	R00654,R04770	RC00196,RC00348,RC01209,RC01210	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_595665_2	378806.STAUR_5231	1.04e-15	81.6	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	ko:K14059	-	-	-	-	ko00000	-	-	-	Arm-DNA-bind_2,Phage_int_SAM_2,Phage_integrase
k59_1593195_1	367299.JOEE01000001_gene2059	1.92e-12	66.2	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4FEJ4@85021|Intrasporangiaceae	201174|Actinobacteria	CP	NADH ubiquinone oxidoreductase subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_1593195_2	367299.JOEE01000001_gene2060	6.06e-94	289.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4FFDF@85021|Intrasporangiaceae	201174|Actinobacteria	C	NADH ubiquinone oxidoreductase subunit	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_478404_1	391587.KAOT1_10601	3.52e-75	242.0	COG0442@1|root,COG0442@2|Bacteria,4NEAF@976|Bacteroidetes,1HXK2@117743|Flavobacteriia	976|Bacteroidetes	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
k59_537235_1	1236541.BALL01000006_gene1014	2.73e-20	86.7	COG3909@1|root,COG3909@2|Bacteria,1N1E5@1224|Proteobacteria,1S4BY@1236|Gammaproteobacteria,2QBTQ@267890|Shewanellaceae	1236|Gammaproteobacteria	C	PFAM cytochrome c class II	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_2
k59_419560_1	648757.Rvan_2746	1.94e-31	122.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2TRMX@28211|Alphaproteobacteria,3N80X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Peptidase M16 inactive domain	MA20_05660	-	-	ko:K07263,ko:K07623	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1183240_1	382464.ABSI01000017_gene68	5.44e-83	278.0	COG1404@1|root,COG3533@1|root,COG3940@1|root,COG4733@1|root,COG1404@2|Bacteria,COG3533@2|Bacteria,COG3940@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.2.1.51,3.2.1.78	ko:K01206,ko:K01218,ko:K09955	ko00051,ko00511,ko02024,map00051,map00511,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000,ko04147	-	GH26,GH29	-	Alginate_lyase,Laminin_G_3,PPC,Peptidase_M8,Peptidase_S8,RicinB_lectin_2,SLH,fn3
k59_1710875_1	1288298.rosmuc_00205	1.42e-80	246.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2U08R@28211|Alphaproteobacteria,46Q89@74030|Roseovarius	28211|Alphaproteobacteria	C	COG0479 Succinate dehydrogenase fumarate reductase, Fe-S protein subunit	frdB	-	1.3.5.4	ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_17,Fer4_8
k59_1478471_1	1121451.DESAM_21292	6.38e-22	98.6	COG0823@1|root,COG0823@2|Bacteria,1MX4U@1224|Proteobacteria,42PEP@68525|delta/epsilon subdivisions,2WJUC@28221|Deltaproteobacteria,2M91V@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Involved in the tonB-independent uptake of proteins	tmcD	-	-	-	-	-	-	-	-	-	-	-	PD40
k59_71666_1	1304275.C41B8_15942	4.45e-45	160.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	ATPase related to phosphate starvation-inducible protein PhoH	phoH	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
k59_1358851_1	1121904.ARBP01000002_gene6986	3.35e-41	152.0	COG0446@1|root,COG0446@2|Bacteria,4PKEU@976|Bacteroidetes,47KJ9@768503|Cytophagia	976|Bacteroidetes	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
k59_248260_1	911239.CF149_02114	8.47e-54	184.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_126508_1	1283287.KB822583_gene2846	1.81e-05	48.5	COG0598@1|root,COG0598@2|Bacteria,2GKNZ@201174|Actinobacteria,4DPRY@85009|Propionibacteriales	201174|Actinobacteria	P	CorA-like Mg2+ transporter protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_1304583_1	643473.KB235930_gene1881	1.35e-16	87.8	COG1361@1|root,COG2931@1|root,COG3210@1|root,COG1361@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,1GJ9G@1117|Cyanobacteria,1HR22@1161|Nostocales	1117|Cyanobacteria	QU	PFAM 3-carboxy-cis,cis-muconate lactonizing enzyme	-	-	3.4.21.10	ko:K01317	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	DUF4347,Lactonase
k59_1067940_1	717785.HYPMC_4170	9.82e-40	141.0	COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,2TS6D@28211|Alphaproteobacteria,3N76Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the pseudomonas-type ThrB family	thrB	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
k59_1067940_2	655981.L8GBV5	1.03e-05	46.6	COG0761@1|root,2QPIQ@2759|Eukaryota,39ZIT@33154|Opisthokonta	33154|Opisthokonta	IM	4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic-like	-	-	-	-	-	-	-	-	-	-	-	-	LYTB
k59_654838_1	234267.Acid_3077	4.56e-73	247.0	COG0304@1|root,COG3321@1|root,COG4221@1|root,COG0304@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,3Y347@57723|Acidobacteria	57723|Acidobacteria	Q	Acyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
k59_1478479_2	931627.MycrhDRAFT_2425	6.56e-35	123.0	COG3809@1|root,COG3809@2|Bacteria,2IKNG@201174|Actinobacteria,239EZ@1762|Mycobacteriaceae	201174|Actinobacteria	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	zf-TFIIB
k59_14535_1	566466.NOR53_3413	6.75e-15	75.5	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
k59_1710881_1	1112209.AHVZ01000026_gene1455	3.35e-05	46.6	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,3NIKK@468|Moraxellaceae	1236|Gammaproteobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0042802,GO:0043021,GO:0043022,GO:0043170,GO:0043335,GO:0043412,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0051083,GO:0061077,GO:0071704,GO:0140096,GO:1901564	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
k59_893373_1	1123267.JONN01000001_gene2092	4.07e-16	76.6	2B276@1|root,31UQJ@2|Bacteria,1QSK5@1224|Proteobacteria,2V1G7@28211|Alphaproteobacteria,2KBI1@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_126516_2	1279019.ARQK01000060_gene2227	1.62e-95	293.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1WWJ8@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_595685_1	314345.SPV1_06999	2.26e-57	193.0	COG2367@1|root,COG2367@2|Bacteria,1R4Y9@1224|Proteobacteria	1224|Proteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase2
k59_952383_1	590998.Celf_0646	2.8e-49	173.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,2I2DU@201174|Actinobacteria,4F33S@85016|Cellulomonadaceae	201174|Actinobacteria	T	histidine kinase HAMP region domain protein	phoR	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_537254_1	977880.RALTA_A1040	1.43e-42	160.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,1JZXQ@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NADH-quinone oxidoreductase	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1478487_1	323261.Noc_2074	4.01e-24	99.0	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,1RMP3@1236|Gammaproteobacteria,1WWKK@135613|Chromatiales	135613|Chromatiales	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
k59_126522_1	1415780.JPOG01000001_gene226	8.28e-55	188.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,1RN57@1236|Gammaproteobacteria,1X48I@135614|Xanthomonadales	135614|Xanthomonadales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
k59_830676_1	159087.Daro_0175	8.35e-55	189.0	COG1819@1|root,COG1819@2|Bacteria,1MVJM@1224|Proteobacteria,2VME8@28216|Betaproteobacteria,2KXTJ@206389|Rhodocyclales	206389|Rhodocyclales	CG	glycosyl	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_830676_2	1121918.ARWE01000001_gene746	3.07e-24	103.0	COG0457@1|root,COG0457@2|Bacteria,1R1JQ@1224|Proteobacteria,4377S@68525|delta/epsilon subdivisions,2WTFW@28221|Deltaproteobacteria,43U9G@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
k59_1478502_1	399739.Pmen_4370	1.35e-84	261.0	COG3239@1|root,COG3239@2|Bacteria,1MXTQ@1224|Proteobacteria,1RRM8@1236|Gammaproteobacteria,1YFKZ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
k59_1243484_1	1049564.TevJSym_ag00520	1.71e-48	165.0	COG3235@1|root,COG3235@2|Bacteria,1RDHR@1224|Proteobacteria,1S3KS@1236|Gammaproteobacteria,1JBXT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Cobalt uptake substrate-specific transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CbiM
k59_302328_1	572479.Hprae_1422	7.09e-41	149.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,3WBJB@53433|Halanaerobiales	186801|Clostridia	L	PFAM Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_1534844_1	309801.trd_0264	2.92e-12	72.4	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2G5Q5@200795|Chloroflexi,27Y10@189775|Thermomicrobia	189775|Thermomicrobia	EU	PFAM peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_1123562_1	1304865.JAGF01000001_gene2689	6.05e-75	238.0	COG5002@1|root,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4F13N@85016|Cellulomonadaceae	201174|Actinobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_1123562_2	593907.Celgi_2332	6.3e-118	347.0	COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria,4F0GT@85016|Cellulomonadaceae	201174|Actinobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_127325_1	765911.Thivi_4566	2.23e-58	196.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RQTW@1236|Gammaproteobacteria,1X2E1@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_596389_1	680646.RMDY18_12470	8.95e-38	144.0	COG1524@1|root,COG1524@2|Bacteria,2GISU@201174|Actinobacteria,1W7F4@1268|Micrococcaceae	201174|Actinobacteria	S	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
k59_16052_1	1089455.MOPEL_083_00210	4.66e-94	283.0	COG1082@1|root,COG1082@2|Bacteria,2GK1S@201174|Actinobacteria,4F6A5@85018|Dermatophilaceae	201174|Actinobacteria	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
k59_303024_1	666681.M301_2753	1.78e-89	266.0	COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,2VS28@28216|Betaproteobacteria,2KKS2@206350|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM cytochrome B561	cybB	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
k59_1535475_1	1075090.GOAMR_46_00080	4.34e-22	95.1	COG1309@1|root,COG1309@2|Bacteria,2I8NQ@201174|Actinobacteria,4GC8T@85026|Gordoniaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	amtR	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_894447_1	1211777.BN77_p10902	1.74e-23	105.0	COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria,2TRT8@28211|Alphaproteobacteria,4B7WN@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
k59_1244524_1	981336.F944_02209	5.13e-44	157.0	COG4292@1|root,COG4292@2|Bacteria,1MW5F@1224|Proteobacteria,1SEG7@1236|Gammaproteobacteria,3NJTX@468|Moraxellaceae	1236|Gammaproteobacteria	S	Bacterial low temperature requirement A protein (LtrA)	-	-	-	-	-	-	-	-	-	-	-	-	LtrA
k59_1244524_2	1496688.ER33_14330	7.35e-60	191.0	COG2085@1|root,COG2085@2|Bacteria,1G18H@1117|Cyanobacteria	1117|Cyanobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
k59_831435_1	349521.HCH_06842	1.35e-22	91.3	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,1S45S@1236|Gammaproteobacteria,1XJM8@135619|Oceanospirillales	135619|Oceanospirillales	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	bfr	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
k59_1128373_1	1172180.KB911775_gene6329	1.19e-41	142.0	COG0745@1|root,COG0745@2|Bacteria,2I8R2@201174|Actinobacteria	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_1128373_2	1906.SFRA_16455	3.07e-05	52.0	COG5002@1|root,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_24217_1	1122603.ATVI01000012_gene1127	1.23e-06	49.3	COG1182@1|root,COG1182@2|Bacteria,1P59R@1224|Proteobacteria,1S337@1236|Gammaproteobacteria,1X6B8@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity	azoR	-	-	ko:K01118	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_2
k59_24217_2	1283300.ATXB01000001_gene1724	2.51e-39	135.0	COG2259@1|root,COG2259@2|Bacteria,1MZVP@1224|Proteobacteria,1S8UI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane	yqjF	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
k59_1313280_1	1193181.BN10_940020	6.82e-165	486.0	COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,4FE8H@85021|Intrasporangiaceae	201174|Actinobacteria	E	ERAP1-like C-terminal domain	pepN	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
k59_1541003_1	2340.JV46_05530	5.32e-48	156.0	COG2010@1|root,COG2010@2|Bacteria,1RDSI@1224|Proteobacteria,1S4BC@1236|Gammaproteobacteria,1J6MF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c	norC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02305	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002	3.D.4.10	-	-	Cytochrom_C
k59_484544_1	367299.JOEE01000005_gene3592	1.47e-12	67.4	COG2197@1|root,COG3899@1|root,COG2197@2|Bacteria,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria,4FEFT@85021|Intrasporangiaceae	201174|Actinobacteria	K	LuxR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,GerE
k59_484544_2	1122997.AUDD01000001_gene2469	0.000104	48.5	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	AbfB,Glyco_hydro_43,Sigma70_r4_2
k59_1599348_1	935839.JAGJ01000013_gene2913	5.21e-38	143.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4F5EF@85017|Promicromonosporaceae	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	fadD2	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_661269_1	1121372.AULK01000003_gene292	7.65e-44	156.0	COG1216@1|root,COG1216@2|Bacteria,2HFK5@201174|Actinobacteria,4FQZF@85023|Microbacteriaceae	201174|Actinobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_80331_1	1089553.Tph_c27680	3.59e-35	125.0	COG5598@1|root,COG5598@2|Bacteria,1V8JT@1239|Firmicutes,24MEE@186801|Clostridia	186801|Clostridia	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
k59_719850_1	519989.ECTPHS_03774	4.26e-86	267.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WX6V@135613|Chromatiales	135613|Chromatiales	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_719850_2	459495.SPLC1_S033580	3.17e-60	202.0	COG2192@1|root,COG2192@2|Bacteria,1G1FV@1117|Cyanobacteria,1H9E9@1150|Oscillatoriales	1117|Cyanobacteria	O	carbamoyl transferase, NodU family	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
k59_902138_1	1118153.MOY_12012	3.9e-63	207.0	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,1XHYN@135619|Oceanospirillales	135619|Oceanospirillales	D	Reduces the stability of FtsZ polymers in the presence of ATP	zapE	-	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
k59_80337_1	765913.ThidrDRAFT_4169	6.58e-54	184.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1WWG8@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
k59_1424667_2	991905.SL003B_1999	1.4e-09	64.7	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2TRS4@28211|Alphaproteobacteria,4BRDV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	MA20_30100	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
k59_24229_1	1122602.ATXP01000001_gene1057	1.21e-10	63.9	COG3920@1|root,COG3920@2|Bacteria,2GKMP@201174|Actinobacteria,1W7FB@1268|Micrococcaceae	201174|Actinobacteria	T	Histidine kinase	pdtaS	GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K00936	-	M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,H_kinase_N,HisKA_2,PAS_4
k59_1541011_1	1121439.dsat_0129	1.31e-154	452.0	COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria,2MB19@213115|Desulfovibrionales	28221|Deltaproteobacteria	N	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
k59_1716975_1	946077.W5A_03179	1.32e-89	278.0	COG0388@1|root,COG0388@2|Bacteria,4NEAQ@976|Bacteroidetes,1HWST@117743|Flavobacteriia	976|Bacteroidetes	S	Carbon-nitrogen hydrolase	ramA_2	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
k59_1365075_1	1249627.D779_3897	7.85e-58	186.0	29HVD@1|root,304SH@2|Bacteria,1RD9R@1224|Proteobacteria,1S46Q@1236|Gammaproteobacteria,1WY83@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_601644_1	768671.ThimaDRAFT_3386	4.42e-60	199.0	COG0265@1|root,COG3016@1|root,COG0265@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,1RPWZ@1236|Gammaproteobacteria,1WX9T@135613|Chromatiales	135613|Chromatiales	O	smart pdz dhr glgf	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg,PDZ_2
k59_1541015_1	1117318.PRUB_08230	2.82e-44	160.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,2Q099@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1541015_2	870187.Thini_0328	5.38e-55	186.0	COG0388@1|root,COG1247@1|root,COG0388@2|Bacteria,COG1247@2|Bacteria,1MX4I@1224|Proteobacteria,1RP30@1236|Gammaproteobacteria,4603U@72273|Thiotrichales	72273|Thiotrichales	M	carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
k59_1424675_1	1238190.AMQY01000013_gene1108	9.8e-11	62.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XH4Q@135619|Oceanospirillales	135619|Oceanospirillales	V	efflux pump	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1424675_2	292415.Tbd_1114	5.05e-57	186.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,2VJ1J@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	fieF	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_719873_1	1120956.JHZK01000004_gene1447	9.4e-28	106.0	COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2U06A@28211|Alphaproteobacteria,1JPFB@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	helix_turn_helix, Lux Regulon	MA20_19670	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_719873_2	713587.THITH_15160	5.6e-13	66.6	COG0784@1|root,COG0784@2|Bacteria,1QEAS@1224|Proteobacteria,1SUMN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_257951_1	349521.HCH_00293	6e-64	212.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1XJDR@135619|Oceanospirillales	135619|Oceanospirillales	T	signal transduction protein with a C-terminal ATPase domain	algZ	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
k59_257951_2	981327.F925_00951	2.29e-08	55.5	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,3NIWF@468|Moraxellaceae	1236|Gammaproteobacteria	KT	LytTr DNA-binding domain	algR	-	-	ko:K08083	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
k59_836963_1	1274.HX89_04475	1.23e-14	72.8	COG1633@1|root,COG1633@2|Bacteria,2I2E1@201174|Actinobacteria,1ZWPM@145357|Dermacoccaceae	201174|Actinobacteria	S	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like	-	-	-	-	-	-	-	-	-	-	-	-	MiaE_2
k59_836963_2	1035308.AQYY01000001_gene2461	1e-18	79.3	2E3M2@1|root,32YJA@2|Bacteria	2|Bacteria	S	Atp-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3107
k59_836963_3	593907.Celgi_0971	5.68e-57	191.0	COG5479@1|root,COG5479@2|Bacteria,2GMJR@201174|Actinobacteria,4F1BQ@85016|Cellulomonadaceae	201174|Actinobacteria	M	Protein of unknown function (DUF3152)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3152
k59_775726_1	392500.Swoo_3327	2.56e-59	207.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,2Q9IC@267890|Shewanellaceae	1236|Gammaproteobacteria	S	PFAM peptidase M16 domain protein	pqqL	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_661298_1	990285.RGCCGE502_16365	1.08e-66	214.0	COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2TSX2@28211|Alphaproteobacteria,4BA0J@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
k59_132967_1	367299.JOEE01000004_gene1000	4.43e-305	839.0	COG0056@1|root,COG0056@2|Bacteria,2GJRJ@201174|Actinobacteria,4FFAR@85021|Intrasporangiaceae	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_1717835_1	880072.Desac_1136	1.95e-56	180.0	COG0824@1|root,COG0824@2|Bacteria	2|Bacteria	IQ	Thioesterase	ysmA	-	3.1.2.23	ko:K01075,ko:K07107	ko00130,ko00362,ko01100,ko01110,ko01120,map00130,map00362,map01100,map01110,map01120	-	R01301	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	4HBT,4HBT_2
k59_602519_1	1049564.TevJSym_ae00550	2.08e-125	389.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1J50T@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	czcA	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
k59_485373_1	497321.C664_07278	7.63e-114	350.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,2KVC6@206389|Rhodocyclales	206389|Rhodocyclales	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k59_1487934_1	1121861.KB899911_gene1195	8.95e-90	280.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSTW@28211|Alphaproteobacteria,2JPPG@204441|Rhodospirillales	204441|Rhodospirillales	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1314481_1	1379281.AVAG01000019_gene1056	1.85e-32	120.0	COG0834@1|root,COG0834@2|Bacteria,1MWDK@1224|Proteobacteria,42NVT@68525|delta/epsilon subdivisions,2WIRY@28221|Deltaproteobacteria,2M8N0@213115|Desulfovibrionales	28221|Deltaproteobacteria	ET	PFAM Extracellular solute-binding protein, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_1541894_1	335543.Sfum_3024	4.47e-143	420.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,2MQ8Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Thiamine pyrophosphate enzyme, central	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1541894_2	1232410.KI421418_gene2271	2.46e-12	63.2	2BNIW@1|root,32H7I@2|Bacteria,1Q1B7@1224|Proteobacteria,43761@68525|delta/epsilon subdivisions,2X24F@28221|Deltaproteobacteria,43SSX@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	ko:K09794	-	-	-	-	ko00000	-	-	-	-
k59_1129135_2	593907.Celgi_0087	1.62e-50	167.0	COG0521@1|root,COG0521@2|Bacteria,2II28@201174|Actinobacteria,4F1GX@85016|Cellulomonadaceae	201174|Actinobacteria	H	Probable molybdopterin binding domain	moaB	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
k59_25266_1	1713.JOFV01000013_gene924	3.21e-40	144.0	COG1189@1|root,COG1189@2|Bacteria,2GJVT@201174|Actinobacteria,4F2AJ@85016|Cellulomonadaceae	201174|Actinobacteria	J	ribosomal RNA methyltransferase RrmJ FtsJ	tlyA	GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
k59_662128_1	314345.SPV1_09583	1.19e-106	332.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria	1224|Proteobacteria	P	ATPase, P-type transporting, HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_1190532_1	582899.Hden_2652	4.07e-88	289.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,3N6A5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Glutamate synthase	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1078878_1	379066.GAU_3726	8.14e-26	106.0	COG3666@1|root,COG3666@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_962324_1	1279019.ARQK01000036_gene1636	2.8e-180	509.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_837813_2	1177181.T9A_03063	4.72e-104	311.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria,1XIV0@135619|Oceanospirillales	135619|Oceanospirillales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_1487948_1	631362.Thi970DRAFT_00683	5.66e-21	92.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,1WWM3@135613|Chromatiales	135613|Chromatiales	S	PFAM Alpha beta hydrolase	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4
k59_1487948_2	1411123.JQNH01000001_gene2630	4.55e-110	335.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_602531_1	316067.Geob_3773	7.76e-42	154.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,42MY5@68525|delta/epsilon subdivisions,2WKST@28221|Deltaproteobacteria,43UAH@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Peptidase dimerisation domain	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_259086_1	1283300.ATXB01000001_gene1930	2.54e-112	355.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XDJF@135618|Methylococcales	135618|Methylococcales	V	Hydrophobe Amphiphile Efflux-1 (HAE1)	-	-	-	ko:K18299	-	M00641	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2.16	-	-	ACR_tran
k59_25285_1	1121396.KB892941_gene3923	1.57e-45	157.0	COG1397@1|root,COG1397@2|Bacteria,1RA82@1224|Proteobacteria,42QPD@68525|delta/epsilon subdivisions,2WMNN@28221|Deltaproteobacteria,2MJI9@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
k59_192492_1	243090.RB6120	7.53e-68	236.0	COG0265@1|root,COG0823@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2234@2|Bacteria,2IXGY@203682|Planctomycetes	203682|Planctomycetes	U	Periplasmic component of the Tol biopolymer transport	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,PDZ_2,Peptidase_M28
k59_903341_1	1049564.TevJSym_ab00650	1.5e-55	192.0	COG2304@1|root,COG2304@2|Bacteria,1MXU0@1224|Proteobacteria,1RZHF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	serine threonine protein kinase	ppkA	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	VWA,VWA_2
k59_25287_1	493475.GARC_2202	1.32e-52	187.0	COG2755@1|root,COG2755@2|Bacteria,1MXTS@1224|Proteobacteria,1RTPH@1236|Gammaproteobacteria,46419@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
k59_1717859_1	935261.JAGL01000002_gene1479	5.68e-24	99.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2U5B1@28211|Alphaproteobacteria,43ICA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Molybdenum ABC transporter	modA	GO:0003674,GO:0005488,GO:0030973,GO:0043167,GO:0043168	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
k59_1717859_2	177439.DP0456	5.53e-118	342.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,42NZV@68525|delta/epsilon subdivisions,2WKDG@28221|Deltaproteobacteria,2MIC6@213118|Desulfobacterales	28221|Deltaproteobacteria	P	TIGRFAM molybdate ABC transporter, inner membrane subunit	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
k59_1717859_3	1123354.AUDR01000016_gene1320	4.49e-75	236.0	COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2VJ3B@28216|Betaproteobacteria,1KRYE@119069|Hydrogenophilales	119069|Hydrogenophilales	P	TOBE domain	-	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
k59_81547_1	666681.M301_0690	1.57e-101	306.0	COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria,2VJZM@28216|Betaproteobacteria,2KKZC@206350|Nitrosomonadales	206350|Nitrosomonadales	I	MaoC like domain	-	-	4.2.1.148	ko:K14449	ko00630,ko00660,ko00720,ko01120,ko01200,map00630,map00660,map00720,map01120,map01200	M00373,M00376,M00740	R05076	RC01984	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
k59_662140_1	1121405.dsmv_0691	3.95e-280	779.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales	68525|delta/epsilon subdivisions	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1660422_1	395494.Galf_2390	1.89e-102	311.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria,1MWDE@1224|Proteobacteria,2WHPR@28216|Betaproteobacteria	28216|Betaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_485399_1	1089552.KI911559_gene2426	1.05e-50	175.0	COG0614@1|root,COG0614@2|Bacteria,1RAUP@1224|Proteobacteria,2TUB0@28211|Alphaproteobacteria,2JSZ7@204441|Rhodospirillales	204441|Rhodospirillales	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
k59_25302_1	744979.R2A130_3520	2.37e-43	149.0	2C1YH@1|root,32R9E@2|Bacteria,1RF0Z@1224|Proteobacteria,2UB3H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
k59_1425539_1	519989.ECTPHS_03602	6.25e-59	189.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,1WY36@135613|Chromatiales	135613|Chromatiales	E	PFAM lipolytic protein G-D-S-L family	-	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
k59_1425539_2	68260.JOAY01000005_gene4887	9.24e-14	71.2	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_776401_1	318167.Sfri_1812	3.35e-108	324.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	FtsX,MacB_PCD
k59_1776343_1	68199.JNZO01000008_gene7629	1.49e-64	201.0	2CXR2@1|root,32T2F@2|Bacteria,2I2M0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1776343_2	1380356.JNIK01000015_gene2321	2.83e-05	45.4	2E35Q@1|root,32Y5M@2|Bacteria,2GS2Q@201174|Actinobacteria,4ETIJ@85013|Frankiales	201174|Actinobacteria	S	Short C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT
k59_1366002_1	42254.XP_004605656.1	6.03e-21	95.1	COG0160@1|root,KOG1404@2759|Eukaryota,38DZP@33154|Opisthokonta,3BF4G@33208|Metazoa,3CSSK@33213|Bilateria,486RG@7711|Chordata,48WNR@7742|Vertebrata,3JCJF@40674|Mammalia	33208|Metazoa	E	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity	AGXT2	GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006081,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006544,GO:0006545,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009078,GO:0009080,GO:0009436,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0016053,GO:0016054,GO:0016223,GO:0016740,GO:0016769,GO:0017144,GO:0019222,GO:0019265,GO:0019481,GO:0019752,GO:0019842,GO:0030170,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031974,GO:0032787,GO:0036094,GO:0042133,GO:0042136,GO:0042802,GO:0042851,GO:0042853,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045428,GO:0045429,GO:0046185,GO:0046394,GO:0046395,GO:0046487,GO:0047305,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0065007,GO:0065008,GO:0070013,GO:0070279,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1903426,GO:1903428,GO:1904407,GO:2000377,GO:2000379	2.6.1.40,2.6.1.44	ko:K00827	ko00250,ko00260,ko00270,ko00280,ko01100,ko01110,map00250,map00260,map00270,map00280,map01100,map01110	-	R00369,R00372,R02050,R10992	RC00006,RC00008,RC00018,RC00160	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_1660423_1	228410.NE1657	2.79e-35	131.0	COG0451@1|root,COG0451@2|Bacteria,1QV3X@1224|Proteobacteria,2WGXG@28216|Betaproteobacteria,371VA@32003|Nitrosomonadales	28216|Betaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_1660423_2	1265313.HRUBRA_01473	1.42e-293	814.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria,1J8WI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	AMP-binding enzyme	JD73_00810	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C_2,PP-binding
k59_1541937_1	933262.AXAM01000043_gene1197	3.68e-18	82.8	COG1465@1|root,COG1465@2|Bacteria,1P42W@1224|Proteobacteria,42MQM@68525|delta/epsilon subdivisions,2WK5X@28221|Deltaproteobacteria,2MIRC@213118|Desulfobacterales	28221|Deltaproteobacteria	E	3-dehydroquinate synthase (EC 4.6.1.3)	-	-	1.4.1.24	ko:K11646	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R08569	RC02302	ko00000,ko00001,ko01000	-	-	-	DHQS
k59_1541937_2	243231.GSU1828	2.24e-14	70.5	COG1605@1|root,COG1605@2|Bacteria,1Q1RX@1224|Proteobacteria,42U9H@68525|delta/epsilon subdivisions,2WQ7P@28221|Deltaproteobacteria,43SMW@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Chorismate mutase type II	-	-	5.4.99.5	ko:K04093	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2
k59_662153_1	338963.Pcar_1708	4.9e-44	161.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,42NKH@68525|delta/epsilon subdivisions,2WJTY@28221|Deltaproteobacteria,43S3Q@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_662153_2	228410.NE2178	6.08e-41	155.0	COG3857@1|root,COG3857@2|Bacteria	2|Bacteria	L	exonuclease activity	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
k59_259121_1	439235.Dalk_1445	1.13e-58	204.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MHZ6@213118|Desulfobacterales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_81575_1	765914.ThisiDRAFT_2746	4.16e-96	293.0	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,1RMGK@1236|Gammaproteobacteria,1WWHA@135613|Chromatiales	135613|Chromatiales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1314542_1	1163617.SCD_n01669	3.13e-11	61.6	COG1848@1|root,COG1848@2|Bacteria,1RA9A@1224|Proteobacteria,2VX83@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PIN domain	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
k59_1314542_2	1121035.AUCH01000006_gene672	7.07e-63	194.0	COG0662@1|root,COG0662@2|Bacteria,1N1XN@1224|Proteobacteria,2VTSM@28216|Betaproteobacteria,2KWJF@206389|Rhodocyclales	206389|Rhodocyclales	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_1078932_1	880072.Desac_2711	4.4e-157	451.0	COG0568@1|root,COG0568@2|Bacteria,1MXGX@1224|Proteobacteria,42PIS@68525|delta/epsilon subdivisions,2WKSS@28221|Deltaproteobacteria,2MQYD@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1425557_1	710696.Intca_0048	1.06e-99	308.0	COG1651@1|root,COG3004@1|root,COG1651@2|Bacteria,COG3004@2|Bacteria,2GM6C@201174|Actinobacteria,4FFGB@85021|Intrasporangiaceae	201174|Actinobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
k59_1717880_1	1265313.HRUBRA_01492	3.92e-185	518.0	COG1442@1|root,COG1442@2|Bacteria,1R5NA@1224|Proteobacteria,1SJX1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_544129_1	873449.STRCR_2155	0.000143	54.7	COG1061@1|root,COG4951@1|root,COG1061@2|Bacteria,COG4951@2|Bacteria,1TS5R@1239|Firmicutes,4HCVA@91061|Bacilli	91061|Bacilli	L	Type III restriction protein res subunit	XK27_08510	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,ResIII
k59_910828_1	1298593.TOL_2863	1.1e-15	77.4	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,1XHHX@135619|Oceanospirillales	135619|Oceanospirillales	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_910828_2	765911.Thivi_3362	4.38e-90	275.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,1WX6S@135613|Chromatiales	135613|Chromatiales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
k59_1724016_2	1121935.AQXX01000093_gene3418	6.66e-49	169.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RMJR@1236|Gammaproteobacteria,1XIS8@135619|Oceanospirillales	135619|Oceanospirillales	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.168	ko:K09699	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R02662,R03174,R04097,R10998	RC00004,RC02727,RC02870	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_912227_1	381666.H16_A1621	8.01e-81	266.0	COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2VNDM@28216|Betaproteobacteria,1KBX2@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Spermine/spermidine synthase domain	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
k59_90429_1	218284.CCDN010000002_gene2070	4.45e-09	62.0	COG1199@1|root,COG1199@2|Bacteria,1TPNB@1239|Firmicutes,4HD6T@91061|Bacilli,1ZAUN@1386|Bacillus	91061|Bacilli	KL	DEAD_2	uvrB3	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DEAD,DEAD_2,HBB,Helicase_C_2,PDDEXK_1
k59_35707_1	56780.SYN_00964	7.05e-58	189.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2WJ2S@28221|Deltaproteobacteria,2MQXG@213462|Syntrophobacterales	28221|Deltaproteobacteria	NT	CheB methylesterase	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
k59_35707_2	1304885.AUEY01000002_gene425	1.15e-12	67.4	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42MR2@68525|delta/epsilon subdivisions,2WKKH@28221|Deltaproteobacteria,2MJG1@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N,Response_reg
k59_781654_1	472759.Nhal_1189	2.82e-82	270.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_843940_1	622637.KE124774_gene3960	5.35e-07	49.3	COG0236@1|root,COG0236@2|Bacteria,1NHIC@1224|Proteobacteria,2UFUJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
k59_843940_2	1386089.N865_20915	1.53e-105	315.0	COG0508@1|root,COG0508@2|Bacteria,2GN5J@201174|Actinobacteria	201174|Actinobacteria	C	acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12,2.3.1.61	ko:K00627,ko:K00658	ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00307	R00209,R02569,R02570,R02571,R08549	RC00004,RC02727,RC02742,RC02833,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1086762_1	2340.JV46_14590	6.8e-93	296.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1J4ES@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_0027,iPC815.YPO0475	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_90446_2	1313301.AUGC01000017_gene802	4.47e-15	77.8	COG1092@1|root,COG1092@2|Bacteria,4NG9S@976|Bacteroidetes	976|Bacteroidetes	J	SAM-dependent methyltransferase	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
k59_315636_1	290318.Cvib_1361	1.26e-72	230.0	COG0502@1|root,COG0502@2|Bacteria	2|Bacteria	H	biotin synthase activity	thiH	GO:0003674,GO:0003824,GO:0005488,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0036355,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	iPC815.YPO3743,iSF_1195.SF4062,iSFxv_1172.SFxv_4429,iS_1188.S3673	BATS,Radical_SAM
k59_726457_1	1064537.AGSO01000011_gene2696	2.63e-11	66.2	COG0627@1|root,COG0627@2|Bacteria,2HEZG@201174|Actinobacteria,4FBC3@85020|Dermabacteraceae	201174|Actinobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_1196757_2	1121405.dsmv_0978	2.24e-28	111.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42MHF@68525|delta/epsilon subdivisions,2WJ1R@28221|Deltaproteobacteria,2MMYC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_608704_2	562970.Btus_3292	8.41e-05	48.1	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,4HA31@91061|Bacilli,27832@186823|Alicyclobacillaceae	91061|Bacilli	O	PFAM peptidase S1 and S6 chymotrypsin Hap	yyxA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_912269_1	1121405.dsmv_0273	3.69e-77	239.0	COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,43AEH@68525|delta/epsilon subdivisions,2WIU2@28221|Deltaproteobacteria,2MJUF@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	yhhJ	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
k59_912269_2	1121405.dsmv_0272	6.08e-22	94.0	COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,43BJ5@68525|delta/epsilon subdivisions,2X713@28221|Deltaproteobacteria,2MJER@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01990,ko:K13926	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3,ABC_tran
k59_383974_1	927658.AJUM01000047_gene2842	1.17e-74	238.0	COG2170@1|root,COG2170@2|Bacteria,4NGA3@976|Bacteroidetes,2G234@200643|Bacteroidia,3XJCB@558415|Marinilabiliaceae	976|Bacteroidetes	S	Glutamate-cysteine ligase family 2(GCS2)	-	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
k59_668006_1	626887.J057_23405	1.65e-74	237.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1RMVU@1236|Gammaproteobacteria,46DFU@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	COG1454 Alcohol dehydrogenase, class IV	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
k59_315647_1	589865.DaAHT2_0189	8.14e-36	132.0	COG0457@1|root,COG3271@1|root,COG0457@2|Bacteria,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,43D5Q@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2,TPR_16
k59_1851777_1	394221.Mmar10_0331	7.47e-68	226.0	COG4783@1|root,COG5616@1|root,COG4783@2|Bacteria,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,2TWZ1@28211|Alphaproteobacteria,44159@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Trans_reg_C
k59_1261018_1	1120936.KB907210_gene5565	1.77e-05	48.5	COG2944@1|root,COG2944@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K07726,ko:K13655	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	HTH_3
k59_1261018_2	1303692.SFUL_3943	3.13e-12	62.4	COG3039@1|root,COG3039@2|Bacteria,2GRAU@201174|Actinobacteria	201174|Actinobacteria	L	Domain of unknown function (DUF397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF397
k59_550052_1	1146883.BLASA_2004	1.03e-71	231.0	COG0531@1|root,COG0531@2|Bacteria,2GJ75@201174|Actinobacteria,4ERYR@85013|Frankiales	201174|Actinobacteria	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease,AA_permease_2
k59_383984_1	1184607.AUCHE_02_00680	6.16e-54	182.0	COG1922@1|root,COG2148@1|root,COG1922@2|Bacteria,COG2148@2|Bacteria,2ICDG@201174|Actinobacteria,4F772@85018|Dermatophilaceae	201174|Actinobacteria	M	Glycosyl transferase WecB/TagA/CpsF family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
k59_35755_1	1267005.KB911264_gene3190	1.03e-122	365.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TR3P@28211|Alphaproteobacteria,3N7KU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_912295_1	590998.Celf_0701	6.79e-32	129.0	COG3459@1|root,COG3459@2|Bacteria	2|Bacteria	G	carbohydrate binding	cbpA	-	2.4.1.333	ko:K21298	-	-	-	-	ko00000,ko01000	-	GH94	-	Glyco_hydro_36,Glyco_transf_36
k59_1724055_1	926550.CLDAP_08580	1.05e-24	100.0	COG3415@1|root,COG3415@2|Bacteria,2G91K@200795|Chloroflexi	200795|Chloroflexi	L	SPTR B0JRC2 Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
k59_1724056_1	644107.SL1157_3100	1.92e-26	104.0	COG1897@1|root,COG1897@2|Bacteria,1MV64@1224|Proteobacteria,2TQUF@28211|Alphaproteobacteria,4NB1C@97050|Ruegeria	28211|Alphaproteobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metAA	-	2.3.1.46	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	M00017	R01777	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	HTS
k59_1724056_2	1121271.AUCM01000001_gene3387	2.59e-23	97.8	COG1132@1|root,COG1132@2|Bacteria,1MX5V@1224|Proteobacteria,2TU1M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	(ABC) transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_139796_1	1479235.KK366039_gene1155	1.63e-59	200.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1XI7H@135619|Oceanospirillales	1236|Gammaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	mltF2	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
k59_198376_1	1123065.ATWL01000004_gene2926	6.41e-33	124.0	COG1082@1|root,COG1082@2|Bacteria,2GJ6E@201174|Actinobacteria	201174|Actinobacteria	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
k59_139797_1	1123256.KB907925_gene1156	5.97e-23	98.6	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RR6H@1236|Gammaproteobacteria,1X5MV@135614|Xanthomonadales	135614|Xanthomonadales	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_139797_2	247634.GPB2148_789	3.25e-91	276.0	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria,1J5TZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	COG0501 Zn-dependent protease with chaperone function	Z012_09445	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k59_35778_1	1123274.KB899431_gene3267	2.3e-12	67.0	COG0576@1|root,COG0576@2|Bacteria,2J7UP@203691|Spirochaetes	203691|Spirochaetes	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_1495482_1	1123255.JHYS01000030_gene195	3.63e-86	274.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2VHUG@28216|Betaproteobacteria,4ABBZ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1323540_1	367299.JOEE01000001_gene1817	9.34e-17	83.2	COG2812@1|root,COG2812@2|Bacteria,2GJKA@201174|Actinobacteria,4FEJB@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
k59_1323540_2	367299.JOEE01000001_gene1818	1.29e-41	142.0	COG0204@1|root,COG0204@2|Bacteria,2GQVG@201174|Actinobacteria,4FFRT@85021|Intrasporangiaceae	201174|Actinobacteria	I	1-acyl-sn-glycerol-3-phosphate acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_843989_1	195250.CM001776_gene3418	8.55e-23	92.4	COG0745@1|root,COG0745@2|Bacteria,1GHYV@1117|Cyanobacteria,1H36Y@1129|Synechococcus	1117|Cyanobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_668036_1	34506.g3249	1.06e-35	138.0	COG0275@1|root,KOG2782@2759|Eukaryota,38UFJ@33154|Opisthokonta,3BEK8@33208|Metazoa,3CUSP@33213|Bilateria	33208|Metazoa	M	rRNA (cytosine-N4-)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_5
k59_1196800_1	335543.Sfum_1202	9.6e-121	370.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MQB9@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_315685_1	760192.Halhy_2013	2.01e-109	327.0	COG0065@1|root,COG0065@2|Bacteria,4NG7E@976|Bacteroidetes,1INV1@117747|Sphingobacteriia	976|Bacteroidetes	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_1371865_1	3702.AT5G45410.2	2.66e-08	56.2	28ISQ@1|root,2QR3Z@2759|Eukaryota,37JJ6@33090|Viridiplantae,3G9EK@35493|Streptophyta,3HRGC@3699|Brassicales	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1371865_2	1906.SFRA_31215	7.91e-92	278.0	COG0428@1|root,COG0428@2|Bacteria	2|Bacteria	P	transporter	-	-	-	ko:K11021,ko:K16267	-	-	-	-	ko00000,ko02000,ko02042	2.A.5.4.11	-	-	Zip
k59_1371865_3	653045.Strvi_9197	1.11e-18	81.6	COG0454@1|root,COG0456@2|Bacteria,2IFM6@201174|Actinobacteria	201174|Actinobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_1323558_1	926560.KE387027_gene262	9.35e-27	104.0	2F64E@1|root,33YNP@2|Bacteria	2|Bacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,MDMPI_N
k59_726506_1	472759.Nhal_0500	8.82e-79	258.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_1323559_1	1121441.AUCX01000005_gene1398	3.7e-59	207.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MG2T@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_139810_1	1125863.JAFN01000001_gene2311	9.09e-21	92.0	COG0215@1|root,COG0215@2|Bacteria	2|Bacteria	J	cysteine-tRNA ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
k59_781705_1	1123253.AUBD01000002_gene1329	1.66e-53	173.0	COG0454@1|root,COG0456@2|Bacteria,1RJ1K@1224|Proteobacteria,1S6RV@1236|Gammaproteobacteria,1X6U1@135614|Xanthomonadales	135614|Xanthomonadales	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_35804_1	1121353.H924_12760	3.2e-07	52.4	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,22R8M@1653|Corynebacteriaceae	201174|Actinobacteria	V	COG1131 ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1431835_1	240016.ABIZ01000001_gene1277	6.52e-33	124.0	COG2255@1|root,COG2255@2|Bacteria,46SDS@74201|Verrucomicrobia,2ITRW@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_1666701_1	1265505.ATUG01000002_gene2025	2.17e-72	238.0	COG2414@1|root,COG2414@2|Bacteria,1R76Y@1224|Proteobacteria,42QE3@68525|delta/epsilon subdivisions,2WIIW@28221|Deltaproteobacteria,2MIUU@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_608760_1	1500894.JQNN01000001_gene3299	6.51e-38	141.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,472EZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17,2.6.1.81	ko:K00821,ko:K00840	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04217,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1086840_1	146922.JOFU01000030_gene5238	1.73e-42	151.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria	201174|Actinobacteria	H	Aminotransferase	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1086840_2	106370.Francci3_0488	9.93e-25	101.0	COG0113@1|root,COG0113@2|Bacteria,2GJJ0@201174|Actinobacteria,4ERR7@85013|Frankiales	201174|Actinobacteria	H	Belongs to the ALAD family	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_971412_1	1266914.ATUK01000018_gene644	6.26e-54	187.0	COG1295@1|root,COG1959@1|root,COG1295@2|Bacteria,COG1959@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1WWKW@135613|Chromatiales	135613|Chromatiales	K	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Rrf2,Virul_fac_BrkB
k59_1196824_1	477974.Daud_0175	1.12e-54	195.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,25ZY7@186807|Peptococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_432727_1	454957.IA64_02275	7.06e-73	229.0	COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,1RR5P@1236|Gammaproteobacteria,1X3A0@135614|Xanthomonadales	135614|Xanthomonadales	S	dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
k59_1666709_2	1121020.JIAG01000001_gene1032	4.93e-37	139.0	COG0494@1|root,COG0494@2|Bacteria,2GNRV@201174|Actinobacteria,1W7NH@1268|Micrococcaceae	201174|Actinobacteria	L	Belongs to the Nudix hydrolase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1,NUDIX
k59_90589_1	357808.RoseRS_0893	3.98e-42	150.0	COG3677@1|root,COG3677@2|Bacteria,2G6SJ@200795|Chloroflexi,3772U@32061|Chloroflexia	32061|Chloroflexia	L	PFAM Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_384107_1	1112212.JH584235_gene1754	1.82e-58	197.0	COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2TSHG@28211|Alphaproteobacteria,2K1R5@204457|Sphingomonadales	204457|Sphingomonadales	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
k59_269402_1	367299.JOEE01000001_gene1861	1.66e-70	215.0	COG0251@1|root,COG0251@2|Bacteria,2IHNE@201174|Actinobacteria,4FGP9@85021|Intrasporangiaceae	201174|Actinobacteria	J	LysR family transcriptional regulator	yabJ	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
k59_269402_3	367299.JOEE01000001_gene1859	1.04e-37	133.0	COG1506@1|root,COG1506@2|Bacteria,2I3Z4@201174|Actinobacteria,4FFYZ@85021|Intrasporangiaceae	201174|Actinobacteria	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Abhydrolase_6,Peptidase_S9
k59_1666720_3	218491.ECA0976	3.29e-36	132.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,1MQ8K@122277|Pectobacterium	1236|Gammaproteobacteria	L	A G-specific adenine glycosylase	mutY	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
k59_1196838_1	1150626.PHAMO_170055	2.22e-31	123.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,2JRK3@204441|Rhodospirillales	204441|Rhodospirillales	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N,Transketolase_C
k59_1196838_2	748247.AZKH_2908	3.26e-63	201.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2VIQM@28216|Betaproteobacteria,2KY5Y@206389|Rhodocyclales	206389|Rhodocyclales	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
k59_1086868_1	864069.MicloDRAFT_00003420	6.01e-62	201.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JW30@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_668075_1	555778.Hneap_1841	5.41e-97	291.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_912403_1	298653.Franean1_0474	1.03e-27	110.0	COG2801@1|root,COG2801@2|Bacteria,2GN25@201174|Actinobacteria	201174|Actinobacteria	L	Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve_3
k59_912403_2	522306.CAP2UW1_2978	1.76e-48	162.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_140688_1	234267.Acid_6655	1.97e-49	167.0	2C57D@1|root,2Z7RS@2|Bacteria,3Y3Y2@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF2891)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2891
k59_1606781_1	1123257.AUFV01000008_gene577	0.000168	48.5	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,1S7VF@1236|Gammaproteobacteria,1X54J@135614|Xanthomonadales	135614|Xanthomonadales	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	tonB1	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
k59_92287_1	177437.HRM2_01780	2.13e-77	252.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4277
k59_609702_1	870187.Thini_2383	0.000261	49.3	COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,1RNJY@1236|Gammaproteobacteria,4619H@72273|Thiotrichales	72273|Thiotrichales	H	HemX, putative uroporphyrinogen-III C-methyltransferase	-	-	2.1.1.107	ko:K02496	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000	-	-	-	HemX
k59_385737_1	1267005.KB911255_gene2617	2.09e-38	136.0	COG0583@1|root,COG0583@2|Bacteria,1MV5N@1224|Proteobacteria,2TRAX@28211|Alphaproteobacteria,3N6I8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	MA20_05050	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_556050_1	765912.Thimo_2234	1.36e-56	186.0	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,1RMFS@1236|Gammaproteobacteria,1WWVD@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
k59_1334267_1	670307.HYPDE_27853	6.29e-18	87.0	COG1196@1|root,COG1196@2|Bacteria,1QW5B@1224|Proteobacteria,2TWN5@28211|Alphaproteobacteria,3N7CD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1553514_1	5145.XP_001908914.1	1.63e-05	47.4	COG0456@1|root,KOG3139@2759|Eukaryota	2759|Eukaryota	J	N-acetyltransferase activity	-	GO:0003674,GO:0003824,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747	-	ko:K19001	-	-	-	-	ko00000,ko03036	-	-	-	Acetyltransf_1
k59_1553514_2	335543.Sfum_2170	1.42e-32	116.0	2AVEY@1|root,31M6X@2|Bacteria,1QJ1U@1224|Proteobacteria,4322P@68525|delta/epsilon subdivisions,2WWRT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
k59_1553514_3	933262.AXAM01000008_gene1954	5.62e-23	94.4	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,42QWG@68525|delta/epsilon subdivisions,2WN1U@28221|Deltaproteobacteria,2MICR@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_786683_1	768671.ThimaDRAFT_2966	1.3e-64	217.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales	135613|Chromatiales	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_497486_1	1123360.thalar_02416	2.62e-77	241.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2TRHR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
k59_674028_1	1151126.AQYI01000002_gene290	3.02e-20	96.3	COG0739@1|root,COG0739@2|Bacteria,2GXEC@201174|Actinobacteria,4FTBE@85023|Microbacteriaceae	201174|Actinobacteria	M	Peptidase family M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
k59_1140089_1	1123368.AUIS01000017_gene2565	2.84e-34	131.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RM90@1236|Gammaproteobacteria,2NCQ3@225057|Acidithiobacillales	225057|Acidithiobacillales	K	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,PAS_4,Sigma54_activat
k59_1611693_1	944481.JAFP01000001_gene1664	3.68e-41	145.0	COG0463@1|root,COG0463@2|Bacteria,1PVP4@1224|Proteobacteria,42M23@68525|delta/epsilon subdivisions,2WNU9@28221|Deltaproteobacteria,2M6AG@213113|Desulfurellales	28221|Deltaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_923028_1	933262.AXAM01000008_gene1943	1.05e-87	285.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria,2MHQD@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthetase large chain oligomerisation	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_1502152_1	257313.BP2905	1.23e-67	221.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,3T26U@506|Alcaligenaceae	28216|Betaproteobacteria	C	Glycolate oxidase subunit	glcD	-	1.1.2.4,1.1.3.15,1.1.5.12	ko:K00102,ko:K00104,ko:K03777	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475,R00704,R11591	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_394582_1	1120944.JONS01000036_gene2543	7.88e-53	171.0	COG3727@1|root,COG3727@2|Bacteria,2IKPY@201174|Actinobacteria,4D5VA@85005|Actinomycetales	201174|Actinobacteria	L	DNA mismatch endonuclease Vsr	vsr	-	-	ko:K07458	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF559,NUDIX,Vsr
k59_394582_2	1304865.JAGF01000001_gene1645	3.67e-21	93.2	COG0270@1|root,COG0270@2|Bacteria	2|Bacteria	L	DNA (cytosine-5-)-methyltransferase activity	hpaIIM	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
k59_732579_1	471853.Bcav_2240	1.64e-122	365.0	COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria	201174|Actinobacteria	S	proteasome accessory factor PafA2	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
k59_1021526_1	1384056.N787_14015	2.6e-53	189.0	COG0643@1|root,COG0784@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1X3AY@135614|Xanthomonadales	135614|Xanthomonadales	T	Chemotaxis protein histidine kinase and related kinases	pilL	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k59_674040_2	1384056.N787_13275	8.91e-14	74.7	2E4BS@1|root,32Z7C@2|Bacteria,1NBM8@1224|Proteobacteria,1T50K@1236|Gammaproteobacteria,1X8D0@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_44210_2	637390.AFOH01000122_gene413	3.95e-45	148.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,1S6FN@1236|Gammaproteobacteria,2ND3Z@225057|Acidithiobacillales	225057|Acidithiobacillales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
k59_44210_3	396588.Tgr7_0995	1.13e-39	139.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S65T@1236|Gammaproteobacteria,1WXHS@135613|Chromatiales	135613|Chromatiales	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_923046_1	179408.Osc7112_5083	6e-88	281.0	COG3957@1|root,COG3957@2|Bacteria,1G0B2@1117|Cyanobacteria,1H7CT@1150|Oscillatoriales	1117|Cyanobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
k59_438745_1	1283300.ATXB01000001_gene1907	3.6e-84	255.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1XEAN@135618|Methylococcales	135618|Methylococcales	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
k59_1334311_1	216142.LT40_06470	1.78e-69	218.0	COG3639@1|root,COG3639@2|Bacteria,1N3HU@1224|Proteobacteria	1224|Proteobacteria	P	COG3639 ABC-type phosphate phosphonate transport system permease component	phnE	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
k59_44219_1	604331.AUHY01000006_gene864	7.71e-129	389.0	COG1640@1|root,COG1640@2|Bacteria,1WJDF@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM glycoside hydrolase, family 77	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k59_44219_2	593907.Celgi_2988	2.55e-58	192.0	COG0644@1|root,COG0644@2|Bacteria,2GM2M@201174|Actinobacteria,4F10K@85016|Cellulomonadaceae	201174|Actinobacteria	C	FAD binding domain	srsC	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FAD_binding_3,FAD_oxidored
k59_1553535_1	765910.MARPU_04975	1.19e-93	288.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1WY1X@135613|Chromatiales	135613|Chromatiales	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
k59_1553535_2	1500894.JQNN01000001_gene1627	2.6e-14	70.5	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2VQ06@28216|Betaproteobacteria,473C9@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
k59_923063_1	1085623.GNIT_1435	6.22e-42	151.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,4661X@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0004048,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016829,GO:0016830,GO:0016833,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042401,GO:0042430,GO:0042435,GO:0042451,GO:0042455,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046219,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657,GO:1901659,GO:1902494	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iSBO_1134.SBO_1803,iSbBS512_1146.SbBS512_E1488,iYL1228.KPN_01256	GATase,Glycos_trans_3N,Glycos_transf_3
k59_732597_1	95619.PM1_0220345	2.19e-06	52.8	COG2373@1|root,COG2931@1|root,COG3170@1|root,COG2373@2|Bacteria,COG2931@2|Bacteria,COG3170@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	von willebrand factor, type A	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2
k59_732597_2	1128421.JAGA01000003_gene3138	1.35e-29	113.0	COG1136@1|root,COG1136@2|Bacteria	2|Bacteria	V	lipoprotein transporter activity	-	GO:0008150,GO:0009405,GO:0009605,GO:0009607,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1553545_1	1125863.JAFN01000001_gene1081	4.39e-23	100.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42NRK@68525|delta/epsilon subdivisions,2WIM6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	recD	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,UvrD_C_2
k59_1554514_2	1123072.AUDH01000001_gene3133	3.53e-18	84.7	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TTCJ@28211|Alphaproteobacteria,2JV7K@204441|Rhodospirillales	204441|Rhodospirillales	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
k59_1268696_1	1265505.ATUG01000002_gene1914	9.9e-152	436.0	arCOG03330@1|root,2Z82Q@2|Bacteria,1NS0Z@1224|Proteobacteria,42YE1@68525|delta/epsilon subdivisions,2WU19@28221|Deltaproteobacteria,2MN37@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Methanol-cobalamin methyltransferase B subunit	-	-	2.1.1.90	ko:K04480	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00356	R04384,R09098	RC00035,RC01144,RC01145,RC02440	ko00000,ko00001,ko00002,ko01000	-	-	-	MtaB
k59_278331_1	670307.HYPDE_37953	1.46e-80	246.0	COG1651@1|root,COG1651@2|Bacteria,1RFF4@1224|Proteobacteria,2U5BN@28211|Alphaproteobacteria,3N72B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Thioredoxin	MA20_42440	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
k59_1731023_1	626887.J057_19930	6.26e-15	69.7	COG3197@1|root,COG3197@2|Bacteria,1NG90@1224|Proteobacteria,1SGQG@1236|Gammaproteobacteria,46912@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	protein, possibly involved in nitrogen fixation	ccoS	-	-	-	-	-	-	-	-	-	-	-	FixS
k59_1731023_2	207954.MED92_03797	6.76e-53	190.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XHFD@135619|Oceanospirillales	135619|Oceanospirillales	P	P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_850765_2	187272.Mlg_1273	7.81e-09	56.2	COG0700@1|root,COG2715@1|root,COG0700@2|Bacteria,COG2715@2|Bacteria,1MVZ0@1224|Proteobacteria,1RRBY@1236|Gammaproteobacteria,1X06W@135613|Chromatiales	135613|Chromatiales	S	Nucleoside recognition	-	-	-	-	-	-	-	-	-	-	-	-	Gate
k59_1612712_1	1121017.AUFG01000058_gene114	3.36e-133	385.0	COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,4FFQG@85021|Intrasporangiaceae	201174|Actinobacteria	P	Part of an ABC transporter complex. Responsible for energy coupling to the transport system	cbiO	-	-	ko:K02006,ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
k59_1094441_1	1034943.BN1094_02231	4.12e-27	111.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,1RMMB@1236|Gammaproteobacteria,1JCK6@118969|Legionellales	118969|Legionellales	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
k59_557019_1	247639.MGP2080_05997	3.24e-134	394.0	COG0446@1|root,COG0446@2|Bacteria,1Q0P8@1224|Proteobacteria,1T1NQ@1236|Gammaproteobacteria,1J7YY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	1.14.19.9	ko:K14266	ko00404,ko01130,map00404,map01130	M00789,M00790	R09570	RC00949	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_halogenase
k59_1731027_1	1304865.JAGF01000001_gene3099	9.56e-55	184.0	COG0446@1|root,COG0446@2|Bacteria,2GRTN@201174|Actinobacteria	201174|Actinobacteria	P	pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DsrC,Pyr_redox_2
k59_396164_1	1144305.PMI02_04518	2.22e-96	296.0	COG3515@1|root,COG3515@2|Bacteria,1NRMK@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_102686_1	768671.ThimaDRAFT_2793	3.86e-230	643.0	COG3039@1|root,COG3039@2|Bacteria,1P2FY@1224|Proteobacteria,1SRZF@1236|Gammaproteobacteria,1X1EC@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_675087_1	467200.ACFA01000917_gene1436	2.59e-88	275.0	COG5361@1|root,COG5361@2|Bacteria,2GRDZ@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_675088_1	1123251.ATWM01000003_gene1186	1.43e-38	147.0	COG0296@1|root,COG3281@1|root,COG0296@2|Bacteria,COG3281@2|Bacteria,2GJ5C@201174|Actinobacteria,4FFH4@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0055114,GO:0071704,GO:0071944,GO:1901576	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k59_1864231_1	160799.PBOR_26405	6.44e-51	182.0	COG3534@1|root,COG3534@2|Bacteria,1TPG2@1239|Firmicutes,4HER2@91061|Bacilli,26UAZ@186822|Paenibacillaceae	91061|Bacilli	G	Alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-L-AF_C,CBM_4_9
k59_850787_2	864051.BurJ1DRAFT_2089	4.96e-19	83.2	COG2142@1|root,COG2142@2|Bacteria,1MZR9@1224|Proteobacteria,2VSJN@28216|Betaproteobacteria,1KKWA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Succinate dehydrogenase hydrophobic membrane anchor protein	sdhD	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_850787_3	85643.Tmz1t_0123	3.44e-26	102.0	COG2009@1|root,COG2009@2|Bacteria,1RIGZ@1224|Proteobacteria,2VW9X@28216|Betaproteobacteria,2KYUG@206389|Rhodocyclales	206389|Rhodocyclales	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_733666_1	211114.JOEF01000003_gene2802	1.38e-21	98.6	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4E1HJ@85010|Pseudonocardiales	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994,ko:K20470	-	-	-	-	ko00000,ko02000	2.A.6.5.6	-	-	MMPL
k59_733667_1	929712.KI912613_gene3445	3.01e-38	146.0	COG2366@1|root,COG2366@2|Bacteria,2GMDM@201174|Actinobacteria	201174|Actinobacteria	S	Penicillin amidase	-	-	3.5.1.97	ko:K07116	-	-	-	-	ko00000,ko01000	-	-	-	Penicil_amidase
k59_1335914_1	68223.JNZY01000043_gene6122	1.22e-47	166.0	COG0128@1|root,COG0128@2|Bacteria,2GJKX@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_1731061_1	1249627.D779_1252	8.46e-17	76.6	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,1WW8M@135613|Chromatiales	135613|Chromatiales	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
k59_1731061_2	765910.MARPU_14080	3.01e-122	354.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,1WX1Y@135613|Chromatiales	135613|Chromatiales	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
k59_983735_1	1300345.LF41_2797	1.82e-83	251.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,1S36X@1236|Gammaproteobacteria,1X3XG@135614|Xanthomonadales	135614|Xanthomonadales	S	FeS assembly SUF system protein SufT	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
k59_498503_1	393595.ABO_0491	4.6e-53	177.0	COG4798@1|root,COG4798@2|Bacteria,1NNHX@1224|Proteobacteria,1RN1A@1236|Gammaproteobacteria,1XJAN@135619|Oceanospirillales	135619|Oceanospirillales	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1673690_1	305700.B447_06482	5.58e-162	462.0	COG3876@1|root,COG3876@2|Bacteria,1MX3S@1224|Proteobacteria,2VMMF@28216|Betaproteobacteria,2KV9B@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
k59_1503141_1	243231.GSU0719	5.02e-97	300.0	COG0412@1|root,COG0412@2|Bacteria,1QW3K@1224|Proteobacteria,43C4E@68525|delta/epsilon subdivisions,2X7EV@28221|Deltaproteobacteria,43S1I@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_322677_1	1232683.ADIMK_2916	1.85e-40	140.0	COG1917@1|root,COG1917@2|Bacteria,1RH0Y@1224|Proteobacteria,1SNIA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_439770_1	1267005.KB911262_gene3322	3.64e-139	400.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2TQZX@28211|Alphaproteobacteria,3N6IB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_1788239_1	760192.Halhy_5945	1.29e-55	190.0	COG1228@1|root,COG1228@2|Bacteria,4NEV0@976|Bacteroidetes,1IWPE@117747|Sphingobacteriia	976|Bacteroidetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_1612761_1	859657.RPSI07_1205	1.55e-33	120.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2VR35@28216|Betaproteobacteria,1K70P@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Yqey-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
k59_1612761_2	1454004.AW11_02393	4.22e-30	116.0	COG4313@1|root,COG4313@2|Bacteria,1PRCN@1224|Proteobacteria,2VQHT@28216|Betaproteobacteria,1KQK1@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
k59_983742_1	1122622.ATWJ01000001_gene2463	4.25e-133	383.0	arCOG06481@1|root,2ZB4E@2|Bacteria,2I95D@201174|Actinobacteria,4FGJ4@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_146838_1	1027273.GZ77_05675	5.15e-77	243.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,1XH3A@135619|Oceanospirillales	135619|Oceanospirillales	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_45424_1	582899.Hden_3410	3.11e-46	166.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2TUSP@28211|Alphaproteobacteria,3N6TS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Peptidase family M23	filA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_787544_1	557598.LHK_03206	2.95e-114	338.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2VHBP@28216|Betaproteobacteria,2KPEA@206351|Neisseriales	206351|Neisseriales	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_1203649_1	1288298.rosmuc_02715	4.14e-137	398.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,2TUJ1@28211|Alphaproteobacteria,46Q3R@74030|Roseovarius	28211|Alphaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	norB	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
k59_733685_2	886293.Sinac_5051	6.03e-45	161.0	COG1502@1|root,COG1502@2|Bacteria,2IYFI@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_983762_2	446471.Xcel_1660	8e-49	171.0	COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,4F49S@85017|Promicromonosporaceae	201174|Actinobacteria	M	Glycosyl transferases group 1	pimA	GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4
k59_1335953_1	1121405.dsmv_2161	4.64e-107	324.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2MHPV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_45435_1	472759.Nhal_1151	6.29e-74	224.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S9S6@1236|Gammaproteobacteria,1WY94@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_146853_1	1548151.LS70_02415	1.21e-22	102.0	COG2855@1|root,COG2855@2|Bacteria,1MVPE@1224|Proteobacteria,42NT6@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	family UPF0324	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
k59_1268765_1	283699.D172_3325	2.86e-37	143.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,2Q0T0@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_2160,iPC815.YPO2428	B3_4,B5,FDX-ACB,tRNA_bind
k59_1335957_1	1385935.N836_31040	1.52e-18	89.7	COG4191@1|root,COG4191@2|Bacteria,1G3MW@1117|Cyanobacteria,1HH50@1150|Oscillatoriales	1117|Cyanobacteria	T	GHKL domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,cNMP_binding
k59_102763_1	748280.NH8B_3602	1.27e-50	175.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,2KPNZ@206351|Neisseriales	206351|Neisseriales	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_111416_1	1380393.JHVP01000003_gene821	1.1e-68	214.0	COG3226@1|root,COG3226@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
k59_152546_1	685727.REQ_17000	4.47e-85	260.0	COG0169@1|root,COG0169@2|Bacteria,2GPXV@201174|Actinobacteria,4FWSX@85025|Nocardiaceae	201174|Actinobacteria	E	Shikimate dehydrogenase substrate binding domain	-	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_dh_N
k59_1275036_2	1049564.TevJSym_ax00300	7.17e-79	243.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1J4GM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_1145858_1	472759.Nhal_0758	7.18e-95	301.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales	135613|Chromatiales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1679204_1	946483.Cenrod_2504	7.7e-57	187.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2VJC3@28216|Betaproteobacteria,4AAJX@80864|Comamonadaceae	28216|Betaproteobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
k59_792019_1	29581.BW37_00253	4.39e-49	166.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,2VHZ0@28216|Betaproteobacteria,4731T@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_792019_2	379731.PST_3297	3.48e-21	90.9	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1Z05P@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	iECH74115_1262.ECH74115_0142,iECSP_1301.ECSP_0134,iECs_1301.ECs0137,iG2583_1286.G2583_0137,iZ_1308.Z0144	Pantoate_ligase
k59_1793107_1	318167.Sfri_3537	1.57e-17	86.7	COG0845@1|root,COG0845@2|Bacteria,1QTZQ@1224|Proteobacteria,1T1J7@1236|Gammaproteobacteria,2QEPD@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_1384470_2	765912.Thimo_2168	1.16e-37	130.0	COG1765@1|root,COG1765@2|Bacteria,1QMYJ@1224|Proteobacteria,1TKA0@1236|Gammaproteobacteria,1X0YP@135613|Chromatiales	135613|Chromatiales	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
k59_210985_1	118166.JH976537_gene3447	6.71e-44	157.0	COG0765@1|root,COG0765@2|Bacteria,1G2E3@1117|Cyanobacteria,1H9HA@1150|Oscillatoriales	1117|Cyanobacteria	P	TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family	-	-	-	ko:K09971	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
k59_621165_1	471853.Bcav_3428	7.97e-101	313.0	COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria	201174|Actinobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_445318_1	1134912.AJTV01000034_gene2323	2.42e-61	199.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2TSFJ@28211|Alphaproteobacteria,36X96@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Dihydrodipicolinate reductase, C-terminus	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
k59_1344836_1	765910.MARPU_15895	5.14e-72	230.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1WVVC@135613|Chromatiales	135613|Chromatiales	F	TIGRFAM dihydroorotase, multifunctional complex type	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_1560266_1	880072.Desac_0718	9.29e-82	256.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2MRG9@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_503947_1	384765.SIAM614_09583	4.21e-08	53.1	COG4731@1|root,COG4731@2|Bacteria,1N7E7@1224|Proteobacteria,2UHSI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
k59_1100534_1	113395.AXAI01000008_gene834	6.15e-66	206.0	COG0822@1|root,COG0822@2|Bacteria,1RDGB@1224|Proteobacteria,2U74A@28211|Alphaproteobacteria,3JRJR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	NifU-like N terminal domain	nifU	-	-	-	-	-	-	-	-	-	-	-	NifU_N
k59_53139_1	1163617.SCD_n01729	7.56e-30	112.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2VHWI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
k59_1209019_1	396588.Tgr7_0991	1.28e-17	81.3	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1WWH3@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_1209019_2	1279019.ARQK01000036_gene1635	7.62e-68	210.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,1WWTG@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM NADH-quinone oxidoreductase, E subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_680846_1	2340.JV46_05300	2.42e-87	263.0	COG2608@1|root,COG2608@2|Bacteria,1P4YG@1224|Proteobacteria,1T20J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Heavy-metal-associated domain	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	HMA
k59_211003_2	1043205.AFYF01000046_gene2962	3.99e-17	79.3	COG4974@1|root,COG4974@2|Bacteria,2I9ZX@201174|Actinobacteria,4FIN9@85021|Intrasporangiaceae	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_621181_1	1336249.JADW01000011_gene1423	4.62e-08	59.7	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TR1D@28211|Alphaproteobacteria,4BAQR@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_1275081_1	1267005.KB911257_gene986	1.51e-106	335.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria,3N6KE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_992601_1	637389.Acaty_c2121	4.83e-93	286.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RM90@1236|Gammaproteobacteria,2NC0Q@225057|Acidithiobacillales	225057|Acidithiobacillales	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat
k59_1560272_1	765912.Thimo_0543	3.61e-108	343.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,1WW9S@135613|Chromatiales	135613|Chromatiales	E	Bacterial transglutaminase-like N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
k59_503955_1	1049564.TevJSym_bb00050	2.74e-83	268.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_1275085_2	1304275.C41B8_01787	9.08e-40	132.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,1S8WZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
k59_680854_1	631362.Thi970DRAFT_00095	1.17e-41	150.0	COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,1RMJC@1236|Gammaproteobacteria,1WWJN@135613|Chromatiales	135613|Chromatiales	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	-	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
k59_680856_1	1382304.JNIL01000001_gene827	4.33e-57	190.0	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,4HDSE@91061|Bacilli,278SD@186823|Alicyclobacillaceae	91061|Bacilli	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1275091_1	1463820.JOGW01000010_gene1112	3.52e-15	80.9	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
k59_111513_2	1157637.KB892091_gene5438	1.74e-31	117.0	COG0664@1|root,COG0664@2|Bacteria,2IRJW@201174|Actinobacteria	201174|Actinobacteria	T	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_111513_3	1304865.JAGF01000001_gene2439	1.56e-27	109.0	COG0479@1|root,COG0479@2|Bacteria,2I37A@201174|Actinobacteria	201174|Actinobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
k59_1100557_1	1041142.ATTP01000069_gene3205	1.94e-92	280.0	COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,2TS6D@28211|Alphaproteobacteria,4B7Z5@82115|Rhizobiaceae	28211|Alphaproteobacteria	F	Belongs to the pseudomonas-type ThrB family	thrB	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
k59_1736613_1	471853.Bcav_1750	4.52e-50	169.0	COG1702@1|root,COG1702@2|Bacteria,2GK0W@201174|Actinobacteria	201174|Actinobacteria	T	phosphate starvation-inducible protein PhoH	phoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_992616_1	1262914.BN533_00388	3.28e-88	278.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,4H2H6@909932|Negativicutes	909932|Negativicutes	V	Efflux ABC transporter permease protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_856302_1	748247.AZKH_1502	2.51e-22	94.4	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,2KUWF@206389|Rhodocyclales	28216|Betaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_856302_2	279714.FuraDRAFT_2622	2.49e-75	245.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,2KPV9@206351|Neisseriales	28216|Betaproteobacteria	O	Heat shock 70 kDa protein	-	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_1793144_1	1122611.KB903959_gene4234	2.34e-50	169.0	COG0559@1|root,COG0559@2|Bacteria,2GKAR@201174|Actinobacteria,4EPNF@85012|Streptosporangiales	201174|Actinobacteria	U	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
k59_503978_1	1385517.N800_13180	3.45e-51	184.0	COG2373@1|root,COG4932@1|root,COG2373@2|Bacteria,COG4932@2|Bacteria,1QZFW@1224|Proteobacteria	1224|Proteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
k59_1344883_1	1123393.KB891332_gene2766	7.75e-07	52.8	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,1KRGG@119069|Hydrogenophilales	119069|Hydrogenophilales	LU	DNA recombination-mediator protein A	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_1344883_2	379731.PST_0022	2.05e-21	93.2	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1YZTS@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	protein containing LysM domain	lysM	-	-	-	-	-	-	-	-	-	-	-	LysM
k59_992628_1	240016.ABIZ01000001_gene292	1.33e-59	207.0	COG0265@1|root,COG0823@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2234@2|Bacteria,46T85@74201|Verrucomicrobia	74201|Verrucomicrobia	OU	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,PD40,PDZ_2,Peptidase_M28
k59_211033_1	643867.Ftrac_2459	3.1e-13	71.6	2E3AK@1|root,32YA3@2|Bacteria,4NT88@976|Bacteroidetes,47V7P@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1100575_1	697282.Mettu_2802	2.96e-40	148.0	COG2199@1|root,COG3159@1|root,COG3159@2|Bacteria,COG3706@2|Bacteria,1R8F2@1224|Proteobacteria,1S284@1236|Gammaproteobacteria,1XESE@135618|Methylococcales	135618|Methylococcales	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	DUF484,GGDEF
k59_405089_1	367299.JOEE01000005_gene3575	1.28e-209	582.0	COG1481@1|root,COG1481@2|Bacteria,2GJZU@201174|Actinobacteria,4FEE7@85021|Intrasporangiaceae	201174|Actinobacteria	K	May be required for sporulation	whiA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0043937,GO:0044464,GO:0050789,GO:0050793,GO:0065007,GO:0071944	-	ko:K09762	-	-	-	-	ko00000	-	-	-	HTH_WhiA,LAGLIDADG_WhiA,WhiA_N
k59_1100582_1	953739.SVEN_3374	4.44e-15	71.6	COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria	201174|Actinobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
k59_1100582_2	367299.JOEE01000001_gene1821	7.16e-66	205.0	299JI@1|root,2ZWN1@2|Bacteria,2GMZP@201174|Actinobacteria,4FGEG@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF5063)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5063
k59_1275129_2	656024.FsymDg_2932	2.25e-28	107.0	COG3654@1|root,COG3654@2|Bacteria,2IR34@201174|Actinobacteria,4ET00@85013|Frankiales	201174|Actinobacteria	S	Fic/DOC family	-	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
k59_152637_1	765911.Thivi_1869	2.24e-128	376.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1WWNU@135613|Chromatiales	135613|Chromatiales	E	PFAM Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_152641_2	670307.HYPDE_24533	3.06e-24	104.0	COG1934@1|root,COG5375@1|root,COG1934@2|Bacteria,COG5375@2|Bacteria,1Q8G1@1224|Proteobacteria,2VEP1@28211|Alphaproteobacteria,3N9AZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Lipopolysaccharide-assembly, LptC-related	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC,OstA
k59_111573_1	1304275.C41B8_00310	1.97e-63	206.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,1RPMP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Peptidyl-prolyl cis-trans	fkpA	GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042026,GO:0042597,GO:0044464	5.2.1.8	ko:K01802,ko:K03772,ko:K03773	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
k59_1028429_1	367299.JOEE01000001_gene1896	2.29e-95	292.0	COG2890@1|root,COG2890@2|Bacteria,2GJPP@201174|Actinobacteria,4FFPS@85021|Intrasporangiaceae	201174|Actinobacteria	J	SAM-dependent methyltransferase	rsmC	-	-	-	-	-	-	-	-	-	-	-	MTS
k59_1737543_1	471853.Bcav_3232	7.24e-112	327.0	COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria	201174|Actinobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044464,GO:0071944	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_112832_1	1454004.AW11_02007	5.39e-184	544.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KQ5Y@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	V	MMPL family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_446270_2	572477.Alvin_0496	3.55e-69	217.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,1WWEI@135613|Chromatiales	135613|Chromatiales	H	PFAM UBA THIF-type NAD FAD binding	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
k59_740435_1	1120954.ATXE01000001_gene2143	1.67e-62	206.0	COG4284@1|root,COG4284@2|Bacteria,2I2G3@201174|Actinobacteria,4DPKI@85009|Propionibacteriales	201174|Actinobacteria	G	UTP--glucose-1-phosphate uridylyltransferase	ugp	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPGP
k59_1028455_1	228410.NE1409	1.04e-34	126.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2VIV6@28216|Betaproteobacteria,372C4@32003|Nitrosomonadales	28216|Betaproteobacteria	K	PFAM Signal transduction response regulator, receiver	-	-	-	ko:K07660	ko01503,ko02020,map01503,map02020	M00444,M00709,M00721,M00723,M00724,M00744	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_54584_1	663610.JQKO01000012_gene3097	1.88e-110	327.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,2U0JR@28211|Alphaproteobacteria,3NC30@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
k59_993841_1	96561.Dole_2062	2.97e-65	207.0	COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,42P8N@68525|delta/epsilon subdivisions,2WIWA@28221|Deltaproteobacteria,2MIT5@213118|Desulfobacterales	28221|Deltaproteobacteria	HP	PFAM ABC transporter related	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_1619398_2	595460.RRSWK_04805	9.03e-22	97.8	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,2IXTY@203682|Planctomycetes	203682|Planctomycetes	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
k59_1028473_1	1463934.JOCF01000039_gene3606	1.99e-25	112.0	COG0392@1|root,COG0392@2|Bacteria,2GMAV@201174|Actinobacteria	201174|Actinobacteria	T	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
k59_563490_2	1249627.D779_1191	1.21e-41	147.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,1RNGN@1236|Gammaproteobacteria,1WXFQ@135613|Chromatiales	135613|Chromatiales	G	PFAM Glucose Sorbosone dehydrogenase	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	GSDH
k59_1874475_2	679197.HMPREF9336_00281	7.57e-15	68.9	2ESIU@1|root,33K3I@2|Bacteria,2GX0D@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1276270_1	288000.BBta_1460	1.94e-212	605.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VGSR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1510493_1	572477.Alvin_2831	6.4e-134	392.0	COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,1WXN5@135613|Chromatiales	135613|Chromatiales	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,DUF3335
k59_1619411_1	1172188.KB911828_gene4085	1.84e-51	172.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4FHH6@85021|Intrasporangiaceae	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.303,1.1.1.4	ko:K00004	ko00650,map00650	-	R02855,R02946,R10504	RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1619411_2	1146883.BLASA_2511	4.75e-54	189.0	COG1129@1|root,COG1172@1|root,COG1129@2|Bacteria,COG1172@2|Bacteria,2GJ3F@201174|Actinobacteria	201174|Actinobacteria	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10440,ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran,BPD_transp_2
k59_1687725_1	439235.Dalk_3615	5.55e-91	286.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2MJ2X@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_1568468_1	314287.GB2207_01892	8.53e-67	221.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,1RMJ0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	choline-sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
k59_798504_1	187272.Mlg_0928	4.45e-20	87.8	COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,1T20F@1236|Gammaproteobacteria,1WW2D@135613|Chromatiales	135613|Chromatiales	E	PFAM Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
k59_798504_2	545264.KB898745_gene1147	2.28e-55	184.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1WXIX@135613|Chromatiales	135613|Chromatiales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_160883_1	1238190.AMQY01000023_gene456	7.59e-18	83.6	COG1262@1|root,COG1262@2|Bacteria,1MVJG@1224|Proteobacteria,1RYY6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
k59_629871_1	2340.JV46_03580	1.84e-78	254.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J8SM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Citrate transporter	sac1	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_689088_1	167555.NATL1_05571	9.87e-20	89.4	COG0548@1|root,COG0548@2|Bacteria,1G0R4@1117|Cyanobacteria,1MKK8@1212|Prochloraceae	1117|Cyanobacteria	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.argB	AA_kinase
k59_689088_2	616991.JPOO01000003_gene1908	3.28e-12	66.6	COG0078@1|root,COG0078@2|Bacteria,4NEYX@976|Bacteroidetes,1HYDI@117743|Flavobacteriia,23GMI@178469|Arenibacter	976|Bacteroidetes	E	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.11,2.1.3.9	ko:K09065,ko:K13043	ko00220,ko01100,ko01230,map00220,map01100,map01230	M00845	R07245,R08937	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_747899_1	290318.Cvib_0894	1.41e-10	62.4	COG1974@1|root,COG1974@2|Bacteria,1FFC3@1090|Chlorobi	1090|Chlorobi	KT	peptidase S24 and S26 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,Peptidase_S24
k59_747899_2	396588.Tgr7_3073	1.74e-53	181.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMFM@1236|Gammaproteobacteria,1WXWQ@135613|Chromatiales	135613|Chromatiales	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k59_866409_2	34506.g2393	3.63e-21	92.0	2D1DQ@1|root,2SHR7@2759|Eukaryota,3AGW4@33154|Opisthokonta,3BYSN@33208|Metazoa,3DEN9@33213|Bilateria,40NV0@6231|Nematoda,1M6AE@119089|Chromadorea,414KR@6236|Rhabditida	33208|Metazoa	S	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1689148_2	1348114.OM33_18540	2.2e-20	92.8	COG3568@1|root,COG3568@2|Bacteria,1RJZP@1224|Proteobacteria,1TEG0@1236|Gammaproteobacteria,2Q45R@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_1454241_1	388051.AUFE01000026_gene5215	2.09e-18	90.5	COG3447@1|root,COG3852@1|root,COG5001@1|root,COG3447@2|Bacteria,COG3852@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria,1K063@119060|Burkholderiaceae	28216|Betaproteobacteria	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,MASE1,PAS_3,PAS_4
k59_631069_1	1410633.JHWR01000001_gene1345	1.08e-06	55.8	COG1086@1|root,COG1086@2|Bacteria,1TR3W@1239|Firmicutes,247PW@186801|Clostridia,27JZ7@186928|unclassified Lachnospiraceae	186801|Clostridia	GM	CoA-binding domain	capD	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
k59_454832_2	765911.Thivi_3383	1.35e-100	305.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1WVWX@135613|Chromatiales	135613|Chromatiales	CH	TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	-	-	-	ko:K18800	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04987,R08768	RC00046	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
k59_1569921_1	446466.Cfla_1356	8.27e-229	645.0	COG0702@1|root,COG0702@2|Bacteria,2GIZA@201174|Actinobacteria,4F143@85016|Cellulomonadaceae	201174|Actinobacteria	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
k59_1628021_1	931276.Cspa_c39430	1.74e-66	218.0	COG2199@1|root,COG2199@2|Bacteria,1V04Z@1239|Firmicutes,24A7E@186801|Clostridia,36F6P@31979|Clostridiaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_1520724_1	314345.SPV1_11761	1.23e-23	99.8	COG1249@1|root,COG1249@2|Bacteria,1MVVE@1224|Proteobacteria	1224|Proteobacteria	C	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation	sthA	GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019725,GO:0022857,GO:0022890,GO:0034220,GO:0036094,GO:0042592,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0065007,GO:0065008,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363,GO:1902600	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	iECED1_1282.ECED1_4669,iECs_1301.ECs4891,iZ_1308.Z5521	Pyr_redox_2,Pyr_redox_dim
k59_1520724_2	1026882.MAMP_02816	6.07e-173	499.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,45ZNP@72273|Thiotrichales	72273|Thiotrichales	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_1746696_1	500153.JOEK01000002_gene205	5.81e-28	117.0	COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,2GJ5U@201174|Actinobacteria	201174|Actinobacteria	C	belongs to the CobB CobQ family	pta	GO:0005575,GO:0005576	2.3.1.8	ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,DRTGG,PTA_PTB
k59_631085_1	375286.mma_1958	8.47e-12	68.9	COG1463@1|root,COG1463@2|Bacteria,1R565@1224|Proteobacteria,2VK63@28216|Betaproteobacteria,473VY@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_690327_2	1504672.669783859	7.66e-21	88.6	COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,2VJXP@28216|Betaproteobacteria,4ACIE@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	fdhB	-	-	ko:K00124,ko:K07307	ko00630,ko00680,ko00920,ko01100,ko01120,ko01200,map00630,map00680,map00920,map01100,map01120,map01200	-	R00519,R09501	RC02555,RC02796	ko00000,ko00001,ko02000	5.A.3.3	-	-	Fer4_11,Fer4_7
k59_631089_1	1250232.JQNJ01000001_gene716	1.46e-05	50.8	COG4659@1|root,COG4659@2|Bacteria,4NPUB@976|Bacteroidetes,1I2MB@117743|Flavobacteriia	976|Bacteroidetes	C	FMN_bind	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
k59_631089_3	1004785.AMBLS11_14655	4.11e-11	62.0	2CH3Z@1|root,32RP9@2|Bacteria,1MZF8@1224|Proteobacteria,1S8TF@1236|Gammaproteobacteria,467CC@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2721
k59_1218937_1	408672.NBCG_01295	9.52e-18	82.8	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4DP5U@85009|Propionibacteriales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1689189_2	402626.Rpic_3261	1.12e-27	109.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2VSEK@28216|Betaproteobacteria,1KH93@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE8	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_513593_1	414684.RC1_0647	6.84e-72	232.0	COG1793@1|root,COG1793@2|Bacteria,1MV3S@1224|Proteobacteria,2TRQ9@28211|Alphaproteobacteria,2JPV7@204441|Rhodospirillales	204441|Rhodospirillales	L	ATP dependent DNA ligase C terminal region	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
k59_162256_1	1210884.HG799466_gene12658	8.65e-27	108.0	COG5433@1|root,COG5433@2|Bacteria,2J33P@203682|Planctomycetes	2|Bacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_749290_1	1163617.SCD_n00360	4.71e-73	238.0	COG0318@1|root,COG0318@2|Bacteria,1MW0Y@1224|Proteobacteria,2VPB2@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	menE	-	6.2.1.26	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_1154577_1	485913.Krac_8409	2.96e-40	152.0	COG0493@1|root,COG0493@2|Bacteria	2|Bacteria	C	'glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_1286711_1	446471.Xcel_2799	7.15e-72	227.0	COG1609@1|root,COG1609@2|Bacteria,2GJBJ@201174|Actinobacteria,4F5JR@85017|Promicromonosporaceae	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
k59_1520781_1	1235457.C404_15290	1.42e-44	160.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2VJVZ@28216|Betaproteobacteria,1JZSN@119060|Burkholderiaceae	28216|Betaproteobacteria	S	DNA recombination protein, rmuC	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
k59_454875_1	1123065.ATWL01000008_gene2400	1.61e-24	100.0	COG1714@1|root,COG1714@2|Bacteria,2H4MP@201174|Actinobacteria	201174|Actinobacteria	A	PFAM RDD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	RDD
k59_454875_2	1282887.AUJG01000002_gene882	2.05e-18	83.6	COG1309@1|root,COG1309@2|Bacteria,1V7SY@1239|Firmicutes,24JI6@186801|Clostridia	186801|Clostridia	K	transcriptional regulator TetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_162280_1	545694.TREPR_2940	7.27e-44	159.0	COG0491@1|root,COG4099@1|root,COG0491@2|Bacteria,COG4099@2|Bacteria,2JBBV@203691|Spirochaetes	203691|Spirochaetes	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_513611_1	243233.MCA0318	4.43e-76	245.0	COG1858@1|root,COG1999@1|root,COG1858@2|Bacteria,COG1999@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1XERF@135618|Methylococcales	135618|Methylococcales	C	PFAM Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
k59_1569985_1	78245.Xaut_1105	3.19e-18	76.6	COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,2UFC1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
k59_1569985_2	1085623.GNIT_3375	7.8e-67	221.0	COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,1RR67@1236|Gammaproteobacteria,466KI@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1569985_3	765914.ThisiDRAFT_0632	1.8e-77	257.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWJ6@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_338565_1	1449976.KALB_3623	5.23e-11	69.3	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria,4DXRX@85010|Pseudonocardiales	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_S8
k59_866493_1	1521187.JPIM01000054_gene3107	4.98e-32	122.0	COG0812@1|root,COG0812@2|Bacteria,2G6H3@200795|Chloroflexi,3754P@32061|Chloroflexia	32061|Chloroflexia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
k59_1801579_1	1282356.H045_13750	6.05e-23	103.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1YPPB@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_749318_1	502025.Hoch_5061	7.18e-44	162.0	COG0339@1|root,COG0339@2|Bacteria,1R4AJ@1224|Proteobacteria,43BI1@68525|delta/epsilon subdivisions,2WMHM@28221|Deltaproteobacteria,2YUF2@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase family M3	prlC	-	3.4.24.15	ko:K01392	ko04614,ko05143,map04614,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M3
k59_1393975_1	1397528.Q671_03475	3.79e-104	324.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,1RPVI@1236|Gammaproteobacteria,1XHJX@135619|Oceanospirillales	135619|Oceanospirillales	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	glcB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_1520803_1	485918.Cpin_5675	2.55e-46	173.0	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,1IQ0T@117747|Sphingobacteriia	976|Bacteroidetes	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
k59_338574_1	713586.KB900536_gene2838	1.43e-65	208.0	COG1249@1|root,COG1249@2|Bacteria	2|Bacteria	C	cell redox homeostasis	-	-	4.99.1.2	ko:K00221	-	-	-	-	ko00000,ko01000	-	-	-	MerB
k59_338580_1	1122963.AUHB01000007_gene3693	7.72e-81	258.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2TQPV@28211|Alphaproteobacteria,36XKX@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Ribosomal protein S1-like RNA-binding domain	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_1038395_1	1415778.JQMM01000001_gene1963	3.91e-29	119.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1J4XQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_1454343_1	1476583.DEIPH_ctg017orf0025	1.37e-51	183.0	COG0366@1|root,COG0366@2|Bacteria,1WIXP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM alpha amylase, catalytic	-	-	2.4.1.4	ko:K05341	ko00500,map00500	-	R01823	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
k59_1628128_1	888056.HMPREF9062_0481	4.72e-07	55.1	COG1609@1|root,COG1609@2|Bacteria,2GK1X@201174|Actinobacteria,4D3SG@85005|Actinomycetales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
k59_220513_1	189753.AXAS01000062_gene8434	2.51e-33	130.0	COG1289@1|root,COG1289@2|Bacteria,1Q5JG@1224|Proteobacteria,2VBX6@28211|Alphaproteobacteria,3K2KA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Aromatic acid exporter family member 1	-	-	-	-	-	-	-	-	-	-	-	-	FUSC
k59_1570023_1	998674.ATTE01000001_gene1596	5.03e-32	126.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,45ZRD@72273|Thiotrichales	72273|Thiotrichales	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
k59_1111966_1	1713.JOFV01000020_gene1357	2.13e-192	548.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4F1WI@85016|Cellulomonadaceae	201174|Actinobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0040007,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_1689281_1	555088.DealDRAFT_0109	6.74e-38	146.0	COG3276@1|root,COG3276@2|Bacteria,1TPQS@1239|Firmicutes,2484U@186801|Clostridia,42JS8@68298|Syntrophomonadaceae	186801|Clostridia	J	Elongation factor SelB winged helix 3	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
k59_866558_1	479431.Namu_4080	1.86e-89	286.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4ERQZ@85013|Frankiales	201174|Actinobacteria	G	pyruvate phosphate dikinase, PEP	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1154652_1	396588.Tgr7_3006	1.67e-22	88.6	2EGIJ@1|root,33AAQ@2|Bacteria,1NH9B@1224|Proteobacteria,1SX44@1236|Gammaproteobacteria,1X1XD@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF2909)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2909
k59_1154652_2	876044.IMCC3088_2521	5.31e-05	46.2	COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,1S8S0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	SURF1-like protein	surf1	-	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
k59_572186_1	1532557.JL37_17040	0.000183	43.1	COG1028@1|root,COG1028@2|Bacteria,1N4J7@1224|Proteobacteria,2VIY3@28216|Betaproteobacteria,3T6QV@506|Alcaligenaceae	28216|Betaproteobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_338640_1	743722.Sph21_2894	7.34e-88	271.0	COG1904@1|root,COG1904@2|Bacteria,4NFHS@976|Bacteroidetes,1IVSK@117747|Sphingobacteriia	976|Bacteroidetes	G	Glucuronate isomerase	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
k59_1570065_1	520709.F985_02023	6.94e-40	152.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,3NM8S@468|Moraxellaceae	1236|Gammaproteobacteria	U	Protein export membrane protein	-	-	-	ko:K18299,ko:K18902	-	M00641,M00698	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.16	-	-	ACR_tran
k59_799577_1	478741.JAFS01000002_gene667	2.01e-41	146.0	COG0176@1|root,COG0176@2|Bacteria,46TCK@74201|Verrucomicrobia,37G0B@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
k59_1689306_1	1541065.JRFE01000029_gene3541	1.82e-46	166.0	COG0659@1|root,COG0659@2|Bacteria,1G1F1@1117|Cyanobacteria,3VJ8P@52604|Pleurocapsales	1117|Cyanobacteria	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1154666_1	1267005.KB911258_gene161	7.54e-84	256.0	COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,2U5DP@28211|Alphaproteobacteria,3N8GQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the LOG family	yvdD	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_1154666_2	1267005.KB911261_gene2248	3.12e-80	248.0	COG1703@1|root,COG1703@2|Bacteria,1R44P@1224|Proteobacteria,2TW2E@28211|Alphaproteobacteria,3N8SH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
k59_1746828_1	429009.Adeg_1356	2.99e-06	52.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,42FBC@68295|Thermoanaerobacterales	186801|Clostridia	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9
k59_1038470_1	768671.ThimaDRAFT_3191	3.45e-57	194.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S720@1236|Gammaproteobacteria,1WYW3@135613|Chromatiales	135613|Chromatiales	O	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8,Trans_reg_C
k59_1520898_1	1121015.N789_12765	1.45e-85	268.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,1X591@135614|Xanthomonadales	135614|Xanthomonadales	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1,Thioredoxin_4
k59_1520898_2	1049564.TevJSym_ao00370	1.03e-37	136.0	COG0720@1|root,COG0720@2|Bacteria,1MXVT@1224|Proteobacteria,1RN6H@1236|Gammaproteobacteria,1J648@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	6-pyruvoyl tetrahydropterin synthase	SO2179	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PTPS
k59_1570091_1	1121405.dsmv_0097	1.11e-72	224.0	COG1392@1|root,COG1392@2|Bacteria,1MXY9@1224|Proteobacteria,42NPT@68525|delta/epsilon subdivisions,2WKR0@28221|Deltaproteobacteria,2MHNF@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_1746844_1	1382306.JNIM01000001_gene221	3.82e-43	154.0	COG0627@1|root,COG0627@2|Bacteria	2|Bacteria	J	Serine hydrolase involved in the detoxification of formaldehyde	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_1154684_1	1304865.JAGF01000001_gene2441	1.49e-108	318.0	COG1941@1|root,COG1941@2|Bacteria,2GSPN@201174|Actinobacteria	201174|Actinobacteria	C	NADH ubiquinone oxidoreductase, 20	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
k59_631219_2	568768.CM001975_gene1743	1.27e-12	68.9	COG4977@1|root,COG4977@2|Bacteria,1MVS8@1224|Proteobacteria,1RQ3Y@1236|Gammaproteobacteria,2JBNM@204037|Dickeya	1236|Gammaproteobacteria	K	helix-turn-helix- domain containing protein AraC type	araC	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006355,GO:0008150,GO:0008152,GO:0009056,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016052,GO:0019219,GO:0019222,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046365,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901575,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K02099	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,HTH_18,HTH_AraC
k59_1154689_1	6669.EFX82049	6.91e-10	65.1	COG5184@1|root,KOG1426@2759|Eukaryota,38GTR@33154|Opisthokonta,3BA8A@33208|Metazoa,3CR9V@33213|Bilateria,41TVS@6656|Arthropoda	33208|Metazoa	I	Regulator of chromosome condensation (RCC1) repeat	RCBTB1	GO:0001669,GO:0003674,GO:0005085,GO:0005087,GO:0005088,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008536,GO:0012505,GO:0017016,GO:0019899,GO:0030141,GO:0031267,GO:0031410,GO:0031982,GO:0043226,GO:0043227,GO:0043229,GO:0044424,GO:0044444,GO:0044464,GO:0051020,GO:0065007,GO:0065009,GO:0097223,GO:0097708,GO:0098772,GO:0099503	-	ko:K11494	-	-	-	-	ko00000,ko03036	-	-	-	BTB,RCC1
k59_1038495_1	1120956.JHZK01000042_gene3051	1.52e-81	265.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,1JQ5T@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1286854_1	1120956.JHZK01000002_gene1004	1.36e-50	173.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,1JPBG@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	acetyl-coa acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C
k59_631223_1	1123399.AQVE01000007_gene1197	1.54e-18	85.9	COG1280@1|root,COG1280@2|Bacteria,1RF18@1224|Proteobacteria,1S4TM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
k59_1689348_1	314232.SKA53_15141	1.56e-93	286.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSG6@28211|Alphaproteobacteria,2P8CX@245186|Loktanella	28211|Alphaproteobacteria	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_1038501_1	765913.ThidrDRAFT_0451	7.6e-22	96.3	COG1527@1|root,COG1527@2|Bacteria,1R7PV@1224|Proteobacteria,1S0C2@1236|Gammaproteobacteria,1WWZK@135613|Chromatiales	135613|Chromatiales	C	(C AC39) subunit	-	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
k59_1640471_1	1499967.BAYZ01000003_gene5870	1.07e-56	186.0	COG4956@1|root,COG4956@2|Bacteria,2NP0D@2323|unclassified Bacteria	2|Bacteria	S	Large family of predicted nucleotide-binding domains	yacL	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	PIN,PIN_4,TRAM
k59_466884_1	1449350.OCH239_20365	6.77e-87	268.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TTAW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_702427_1	399739.Pmen_0675	1.28e-172	487.0	COG4663@1|root,COG4663@2|Bacteria,1MUA1@1224|Proteobacteria,1RYNZ@1236|Gammaproteobacteria,1YHEZ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	Q	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1167120_1	1336243.JAEA01000008_gene934	1.78e-24	99.4	COG3485@1|root,COG3485@2|Bacteria,1MV3B@1224|Proteobacteria,2TTZJ@28211|Alphaproteobacteria,1JV1E@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	TIGRFAM protocatechuate 3,4-dioxygenase, alpha subunit	pcaG	-	1.13.11.3	ko:K00448	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
k59_1167120_2	314264.ROS217_13581	1.6e-14	71.6	COG3485@1|root,COG3485@2|Bacteria,1MUYX@1224|Proteobacteria,2TU2C@28211|Alphaproteobacteria,46QGR@74030|Roseovarius	28211|Alphaproteobacteria	Q	Protocatechuate 3,4-dioxygenase beta subunit N terminal	pcaH	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C,PCDO_beta_N
k59_350708_1	435908.IDSA_01335	7.72e-83	270.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,2QFP3@267893|Idiomarinaceae	1236|Gammaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_0027,iPC815.YPO0475	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_466905_1	706587.Desti_3788	2.77e-54	179.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,42N58@68525|delta/epsilon subdivisions,2WIQS@28221|Deltaproteobacteria,2MQWK@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	PhoH-like protein	phoH2	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_466907_1	522772.Dacet_1218	3.01e-31	123.0	COG4666@1|root,COG4666@2|Bacteria,2GEUP@200930|Deferribacteres	200930|Deferribacteres	S	transport system permease	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_466907_2	1232410.KI421422_gene2087	1.72e-10	63.2	COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WRFB@28221|Deltaproteobacteria,43UR0@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_1055262_1	1713.JOFV01000014_gene875	2.09e-95	291.0	COG4177@1|root,COG4177@2|Bacteria,2GJB3@201174|Actinobacteria,4F1SR@85016|Cellulomonadaceae	201174|Actinobacteria	E	Branched-chain amino acid transport system / permease component	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1583384_1	446471.Xcel_2988	1.73e-25	99.4	COG0634@1|root,COG0634@2|Bacteria,2GMDZ@201174|Actinobacteria,4F38R@85017|Promicromonosporaceae	201174|Actinobacteria	F	Phosphoribosyl transferase domain	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
k59_1583384_2	1033730.CAHG01000006_gene998	1.3e-21	94.7	COG0037@1|root,COG0037@2|Bacteria,2GJR4@201174|Actinobacteria,4DQ41@85009|Propionibacteriales	201174|Actinobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	GO:0008150,GO:0040007	2.4.2.8,6.3.4.19	ko:K00760,ko:K04075	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016	-	-	-	ATP_bind_3,TilS
k59_1465941_1	765911.Thivi_2434	1.21e-132	393.0	COG0768@1|root,COG0768@2|Bacteria,1R913@1224|Proteobacteria,1RSPR@1236|Gammaproteobacteria,1WXE0@135613|Chromatiales	135613|Chromatiales	M	penicillin-binding protein	-	-	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
k59_1813060_1	1121019.AUMN01000014_gene4152	1.51e-09	58.5	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,1W8HF@1268|Micrococcaceae	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1583402_1	1111121.HMPREF1247_1046	3.15e-05	49.3	COG2208@1|root,COG2208@2|Bacteria,2GJSK@201174|Actinobacteria,4CV7N@84998|Coriobacteriia	84998|Coriobacteriia	T	Stage II sporulation protein E	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,PAS,SpoIIE
k59_1583402_2	290512.Paes_0830	4.93e-31	113.0	COG2077@1|root,COG2077@2|Bacteria,1FDXA@1090|Chlorobi	1090|Chlorobi	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	tpx	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
k59_1465949_1	1408424.JHYI01000010_gene733	4.02e-05	45.8	COG0673@1|root,COG0673@2|Bacteria,1TPT5@1239|Firmicutes,4HAPJ@91061|Bacilli,1ZDI9@1386|Bacillus	91061|Bacilli	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_466959_2	795955.AFRW01000116_gene1144	1.17e-20	94.4	COG0770@1|root,COG0770@2|Bacteria,2GK0Y@201174|Actinobacteria,1W7YT@1268|Micrococcaceae	201174|Actinobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1757915_1	1500894.JQNN01000001_gene3993	6.73e-21	97.8	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,4729N@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
k59_1465964_1	313589.JNB_18188	1.86e-25	101.0	2CT9V@1|root,32SSX@2|Bacteria,2GKR6@201174|Actinobacteria,4FH9P@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4129)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
k59_1406727_1	933262.AXAM01000048_gene2591	1.07e-110	345.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2WITS@28221|Deltaproteobacteria,2MIFX@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,PurS
k59_1055352_1	62928.azo2660	2.69e-80	243.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VR39@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM PEBP family protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
k59_523078_1	1304865.JAGF01000001_gene2602	7.51e-28	107.0	COG1216@1|root,COG1216@2|Bacteria,2I2J1@201174|Actinobacteria,4F33X@85016|Cellulomonadaceae	201174|Actinobacteria	S	Glycosyltransferase like family 2	ycbB	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_762779_1	6500.XP_005109585.1	2.99e-98	307.0	COG0362@1|root,KOG2653@2759|Eukaryota,38BP7@33154|Opisthokonta,3BBQ7@33208|Metazoa,3CW4B@33213|Bilateria	33208|Metazoa	G	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	PGD	GO:0000166,GO:0003674,GO:0003824,GO:0004616,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006082,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0009051,GO:0009058,GO:0009117,GO:0009605,GO:0009607,GO:0009617,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0019222,GO:0019321,GO:0019322,GO:0019362,GO:0019520,GO:0019521,GO:0019637,GO:0019682,GO:0019693,GO:0019752,GO:0030246,GO:0031406,GO:0032787,GO:0033500,GO:0034641,GO:0036094,GO:0042592,GO:0042593,GO:0042742,GO:0043167,GO:0043168,GO:0043177,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046483,GO:0046496,GO:0048037,GO:0048519,GO:0048878,GO:0050661,GO:0050662,GO:0050789,GO:0050829,GO:0050896,GO:0051156,GO:0051186,GO:0051704,GO:0051707,GO:0055086,GO:0055114,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0072524,GO:0097159,GO:0098542,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901576	1.1.1.343,1.1.1.44	ko:K00033,ko:K11511	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko03460,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map03460	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000,ko03036,ko03400	-	-	-	6PGD,NAD_binding_2
k59_467019_2	590998.Celf_2349	9.79e-34	124.0	COG1385@1|root,COG1385@2|Bacteria,2GTKX@201174|Actinobacteria,4F0KK@85016|Cellulomonadaceae	201174|Actinobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
k59_1055372_1	1336245.JAGO01000011_gene157	6.83e-24	102.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1XHBY@135619|Oceanospirillales	135619|Oceanospirillales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_1055372_2	768671.ThimaDRAFT_2163	4.33e-43	144.0	COG0346@1|root,COG0346@2|Bacteria,1RGZ8@1224|Proteobacteria,1S66M@1236|Gammaproteobacteria,1WYT7@135613|Chromatiales	135613|Chromatiales	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
k59_1055372_3	754477.Q7C_686	3.94e-41	147.0	COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,1S416@1236|Gammaproteobacteria,4616F@72273|Thiotrichales	72273|Thiotrichales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_233532_2	768671.ThimaDRAFT_1815	9.88e-85	255.0	COG2259@1|root,COG2259@2|Bacteria,1RBZP@1224|Proteobacteria,1S28E@1236|Gammaproteobacteria,1WYB3@135613|Chromatiales	135613|Chromatiales	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
k59_809747_1	1267534.KB906755_gene4805	1.8e-12	74.3	28MAS@1|root,2ZAPE@2|Bacteria,3Y6VW@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function, DUF481	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
k59_467050_1	585531.HMPREF0063_11372	5.62e-81	248.0	COG4149@1|root,COG4149@2|Bacteria,2GJFB@201174|Actinobacteria,4DPG9@85009|Propionibacteriales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	modB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,BPD_transp_1,TOBE
k59_467050_2	1041522.MCOL_V209360	1.61e-05	47.0	COG0725@1|root,COG0725@2|Bacteria,2GMPF@201174|Actinobacteria,234BP@1762|Mycobacteriaceae	201174|Actinobacteria	P	ABC transporter, periplasmic molybdate-binding protein	modA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0040007,GO:0042597,GO:0043167,GO:0043168,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
k59_702544_1	1123239.KB898627_gene3338	7.32e-36	135.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,4HAEE@91061|Bacilli	91061|Bacilli	E	Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes	nifZ	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_523114_2	396588.Tgr7_0333	6.43e-82	256.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1WWMQ@135613|Chromatiales	135613|Chromatiales	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_702548_2	883080.HMPREF9697_02442	8.58e-44	149.0	2CUA5@1|root,32SUX@2|Bacteria,1RJP0@1224|Proteobacteria,2U9T0@28211|Alphaproteobacteria,3K0GI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Complex I intermediate-associated protein 30 (CIA30)	-	-	-	-	-	-	-	-	-	-	-	-	CIA30
k59_642222_1	580332.Slit_0818	3.16e-54	181.0	COG5660@1|root,2Z7TM@2|Bacteria,1PMCV@1224|Proteobacteria,2VWPY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TRAP transporter T-component	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
k59_762815_1	926550.CLDAP_40110	2.46e-76	238.0	COG1172@1|root,COG1172@2|Bacteria,2G6DF@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10561	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.9	-	-	BPD_transp_2
k59_467069_1	1267005.KB911257_gene930	1.16e-120	371.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,3N66E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_523123_1	794903.OPIT5_04415	2.96e-90	277.0	COG3550@1|root,COG3550@2|Bacteria,46XT4@74201|Verrucomicrobia,3K8Y8@414999|Opitutae	414999|Opitutae	S	Pfam:HipA_N	-	-	2.7.11.1	ko:K07154	-	-	-	-	ko00000,ko01000,ko01001,ko02048	-	-	-	Couple_hipA,HipA_C
k59_233558_1	1026882.MAMP_02779	1.6e-91	283.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMFM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF4113,IMS,IMS_C
k59_233558_2	1026882.MAMP_00291	6.01e-62	193.0	2E1WQ@1|root,32X5W@2|Bacteria,1N2F8@1224|Proteobacteria,1SA2N@1236|Gammaproteobacteria,462KZ@72273|Thiotrichales	72273|Thiotrichales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1466020_1	27923.ML10592a-PA	1.64e-05	49.7	COG0666@1|root,KOG0510@2759|Eukaryota,38G7Q@33154|Opisthokonta,3BCDU@33208|Metazoa	33208|Metazoa	DZ	osmolarity-sensing cation channel activity	-	GO:0005575,GO:0005623,GO:0005929,GO:0036477,GO:0042995,GO:0043025,GO:0043226,GO:0044297,GO:0044464,GO:0097458,GO:0097730,GO:0120025	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,Ion_trans
k59_642241_2	1121935.AQXX01000100_gene1295	3.46e-15	73.9	COG0517@1|root,COG0517@2|Bacteria,1QTZR@1224|Proteobacteria,1S7SY@1236|Gammaproteobacteria,1XKDN@135619|Oceanospirillales	135619|Oceanospirillales	S	COG0517 FOG CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
k59_233559_1	1123065.ATWL01000002_gene1431	1.45e-91	278.0	COG2177@1|root,COG2177@2|Bacteria,2GJMA@201174|Actinobacteria	201174|Actinobacteria	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
k59_523134_1	1163617.SCD_n02414	2.13e-29	110.0	COG0500@1|root,COG0500@2|Bacteria,1RDHE@1224|Proteobacteria,2VQIP@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Protein of unknown function (DUF938)	-	-	-	-	-	-	-	-	-	-	-	-	DUF938
k59_523134_2	1123073.KB899245_gene43	1.71e-14	70.1	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S607@1236|Gammaproteobacteria,1XCK0@135614|Xanthomonadales	135614|Xanthomonadales	O	Hsp20/alpha crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
k59_1583486_1	869213.JCM21142_31204	3.98e-61	204.0	COG1249@1|root,COG1249@2|Bacteria,4NJ2P@976|Bacteroidetes,47NRN@768503|Cytophagia	976|Bacteroidetes	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1640614_1	497964.CfE428DRAFT_0258	4.13e-19	91.7	COG0577@1|root,COG5621@1|root,COG0577@2|Bacteria,COG5621@2|Bacteria,46SI8@74201|Verrucomicrobia	74201|Verrucomicrobia	V	MacB-like periplasmic core domain	salY	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1759860_2	1123228.AUIH01000004_gene1093	5.41e-56	184.0	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,1RYJY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	carbon monoxide dehydrogenase	-	-	1.2.5.3,1.3.99.8	ko:K03519,ko:K16878	ko00365,ko01120,map00365,map01120	-	R02987,R11168	RC01856,RC02800	ko00000,ko00001,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
k59_1170206_1	1163617.SCD_n00375	1.06e-69	215.0	COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,2VR9X@28216|Betaproteobacteria	28216|Betaproteobacteria	K	transcriptional regulator AsnC family	nirH	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
k59_1816128_1	331678.Cphamn1_1670	3.05e-39	139.0	COG1397@1|root,COG1397@2|Bacteria	2|Bacteria	O	ADP-ribosylglycohydrolase	draG	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH,Inositol_P
k59_1816128_2	246195.DNO_0173	2.66e-88	285.0	COG1204@1|root,COG1204@2|Bacteria,1MW4Z@1224|Proteobacteria,1RXXN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DEAD DEAH box helicase	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
k59_1408412_1	94122.Shewana3_4109	1.46e-72	242.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,2Q9N3@267890|Shewanellaceae	1236|Gammaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1170259_1	1279017.AQYJ01000020_gene1277	8.07e-28	121.0	COG1566@1|root,COG1566@2|Bacteria,1RJ3I@1224|Proteobacteria,1S7BS@1236|Gammaproteobacteria,46ACD@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Protein of unknown function (DUF3667)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3667
k59_1170267_1	880072.Desac_1854	3.76e-51	172.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria	2|Bacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	-	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_1816195_1	926550.CLDAP_37950	1.26e-86	265.0	COG1131@1|root,COG1131@2|Bacteria,2G5RD@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_644374_1	519989.ECTPHS_01844	9.28e-122	367.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1WWDS@135613|Chromatiales	135613|Chromatiales	M	Catalyzes cross-linking of the peptidoglycan cell wall at the division septum	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
k59_644374_2	342610.Patl_3526	8.61e-07	50.4	COG3116@1|root,COG3116@2|Bacteria,1N9MH@1224|Proteobacteria,1SC7P@1236|Gammaproteobacteria,2Q2TU@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsL	GO:0000003,GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0019954,GO:0022402,GO:0022414,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0043093,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944	-	ko:K03586	-	-	-	-	ko00000,ko03036	-	-	-	FtsL
k59_644374_3	1007104.SUS17_2257	3.42e-14	73.2	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2TRQA@28211|Alphaproteobacteria,2K178@204457|Sphingomonadales	204457|Sphingomonadales	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_584659_1	590998.Celf_0907	3.32e-10	61.2	COG0560@1|root,COG0560@2|Bacteria,2GJW9@201174|Actinobacteria,4F0I8@85016|Cellulomonadaceae	201174|Actinobacteria	E	haloacid dehalogenase-like hydrolase	serB1	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HAD
k59_584659_2	469371.Tbis_0259	1.11e-23	93.2	COG0695@1|root,COG0695@2|Bacteria,2IR0P@201174|Actinobacteria,4E5DS@85010|Pseudonocardiales	201174|Actinobacteria	O	PFAM Glutaredoxin-like domain (DUF836)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF836
k59_1816209_1	1198232.CYCME_0263	1.07e-131	385.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,461TD@72273|Thiotrichales	72273|Thiotrichales	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k59_584691_1	1304865.JAGF01000001_gene3333	4.31e-49	174.0	COG2608@1|root,COG2836@1|root,COG4633@1|root,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,2IETB@201174|Actinobacteria	201174|Actinobacteria	P	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,DsbD_2,HMA
k59_811547_1	1395571.TMS3_0111900	7.99e-33	130.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	fleQ	-	-	ko:K10941	ko02020,ko02025,ko05111,map02020,map02025,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	FleQ,HTH_8,Sigma54_activat
k59_584710_1	1499686.BN1079_00720	2.16e-28	120.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	peptidylprolyl isomerase	ppiD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0061077,GO:0071575,GO:0071944,GO:0098552	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
k59_1642364_1	1123279.ATUS01000004_gene3031	4.37e-35	130.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,1RVNC@1236|Gammaproteobacteria,1J97N@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
k59_584749_1	643867.Ftrac_0675	2.31e-42	150.0	COG0330@1|root,COG0330@2|Bacteria,4NHUE@976|Bacteroidetes,47K05@768503|Cytophagia	976|Bacteroidetes	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_1170415_1	1292034.OR37_03090	8.72e-34	131.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	gamma-glutamyltransferase	ggt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_811641_1	1343739.PAP_08735	1.99e-38	139.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,244E3@183968|Thermococci	183968|Thermococci	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1170483_1	1255043.TVNIR_1444	7.29e-16	73.6	COG2142@1|root,COG2142@2|Bacteria,1RH1K@1224|Proteobacteria,1S7GT@1236|Gammaproteobacteria,1WYKS@135613|Chromatiales	135613|Chromatiales	C	Succinate dehydrogenase hydrophobic membrane anchor	-	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_1170502_2	382245.ASA_3690	7.67e-25	105.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,1RP16@1236|Gammaproteobacteria,1Y4SA@135624|Aeromonadales	135624|Aeromonadales	M	Biotin-lipoyl like	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_525446_1	96561.Dole_2696	6.74e-64	218.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2MHW3@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1170508_1	631362.Thi970DRAFT_01797	9.42e-29	114.0	COG2067@1|root,COG2067@2|Bacteria,1RJIQ@1224|Proteobacteria,1SAC1@1236|Gammaproteobacteria,1WZ89@135613|Chromatiales	135613|Chromatiales	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_824085_2	768671.ThimaDRAFT_1347	7.97e-08	53.1	28JVF@1|root,2Z9KD@2|Bacteria,1MXZ6@1224|Proteobacteria,1RY7E@1236|Gammaproteobacteria,1WX1M@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1176578_1	1283300.ATXB01000001_gene480	4.37e-62	213.0	COG0438@1|root,COG0438@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,1XDS7@135618|Methylococcales	1224|Proteobacteria	M	Sucrose phosphate synthase, sucrose phosphatase-like	mfpsA	GO:0003674,GO:0003824,GO:0005975,GO:0005984,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0034637,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0071704,GO:1901576	2.4.1.246	ko:K13058	-	-	R08947	RC00005,RC00028	ko00000,ko01000	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
k59_413237_1	1123368.AUIS01000005_gene483	3.19e-108	325.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,2NBWP@225057|Acidithiobacillales	225057|Acidithiobacillales	C	4Fe-4S dicluster domain	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7
k59_413237_2	439235.Dalk_3515	1.34e-08	55.8	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,2MHZK@213118|Desulfobacterales	28221|Deltaproteobacteria	EH	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	1.2.5.1,2.2.1.6	ko:K00156,ko:K01652	ko00290,ko00620,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00620,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R03145,R04672,R04673,R08648	RC00027,RC00106,RC00860,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1587218_1	1469607.KK073768_gene3918	7.33e-80	244.0	COG3335@1|root,COG3335@2|Bacteria,1G60T@1117|Cyanobacteria	1117|Cyanobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23
k59_1587218_2	118161.KB235918_gene79	2.41e-26	106.0	COG3415@1|root,COG3415@2|Bacteria,1GEDQ@1117|Cyanobacteria	1117|Cyanobacteria	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
k59_1823549_1	635013.TherJR_2223	5.49e-49	177.0	COG1470@1|root,COG5276@1|root,COG1470@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	Big_5,CarboxypepD_reg,DUF1566,He_PIG,LVIVD,SLH
k59_3245_1	713586.KB900536_gene3092	6.75e-30	125.0	COG1629@1|root,COG4771@2|Bacteria,1MX42@1224|Proteobacteria,1RQ2K@1236|Gammaproteobacteria,1WWEW@135613|Chromatiales	135613|Chromatiales	P	TonB-dependent heme hemoglobin receptor	-	-	-	ko:K16087	-	-	-	-	ko00000,ko02000	1.B.14.2	-	-	Plug,TonB_dep_Rec
k59_1059459_1	96561.Dole_1175	2.5e-117	350.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2WITH@28221|Deltaproteobacteria,2MHR7@213118|Desulfobacterales	28221|Deltaproteobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	algC	-	5.4.2.2,5.4.2.8	ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_237631_1	765911.Thivi_4476	3.68e-90	271.0	COG0627@1|root,COG0627@2|Bacteria,1MUID@1224|Proteobacteria,1RMR3@1236|Gammaproteobacteria,1WXDM@135613|Chromatiales	135613|Chromatiales	S	Serine hydrolase involved in the detoxification of formaldehyde	-	-	3.1.2.12	ko:K01070	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R00527	RC00167,RC00320	ko00000,ko00001,ko01000	-	CE1	-	Esterase
k59_884406_1	1348657.M622_04785	6.04e-07	50.1	COG2142@1|root,COG2142@2|Bacteria,1ND98@1224|Proteobacteria,2VVSF@28216|Betaproteobacteria,2KZ04@206389|Rhodocyclales	206389|Rhodocyclales	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_884406_2	1249627.D779_3516	3.38e-75	240.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales	135613|Chromatiales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_943130_2	1381123.AYOD01000002_gene686	6.34e-31	119.0	COG0685@1|root,COG0685@2|Bacteria,1MVWT@1224|Proteobacteria,2TTSF@28211|Alphaproteobacteria,43KAG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	COG0685 5,10-methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
k59_530855_1	335543.Sfum_0064	3.38e-109	323.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,42N8G@68525|delta/epsilon subdivisions,2WKBC@28221|Deltaproteobacteria,2MQ75@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_943134_1	1124780.ANNU01000043_gene331	1.41e-77	240.0	COG1073@1|root,COG1073@2|Bacteria,4NMZQ@976|Bacteroidetes	976|Bacteroidetes	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
k59_1295337_1	395493.BegalDRAFT_2380	5.06e-31	118.0	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,1RQBE@1236|Gammaproteobacteria,45ZXH@72273|Thiotrichales	72273|Thiotrichales	O	TIGRFAM hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
k59_589582_1	96561.Dole_1268	2.08e-134	406.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria,2MHQW@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_1763444_1	1117647.M5M_16240	1.39e-73	233.0	COG1257@1|root,COG1257@2|Bacteria,1Q6M1@1224|Proteobacteria,1RPEP@1236|Gammaproteobacteria,1J4EM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	COG1257 Hydroxymethylglutaryl-CoA reductase	-	-	1.1.1.34	ko:K00021	ko00900,ko01100,ko01110,ko01130,ko04152,ko04976,map00900,map01100,map01110,map01130,map04152,map04976	M00095	R02082	RC00004,RC00644	ko00000,ko00001,ko00002,ko01000	-	-	-	HMG-CoA_red
k59_119932_2	1211035.CD30_12960	3.97e-47	158.0	COG4665@1|root,COG4665@2|Bacteria	2|Bacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	dctQ5	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_1000285_1	316058.RPB_1175	3.52e-33	116.0	COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,2UF4F@28211|Alphaproteobacteria,3K056@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
k59_1000285_2	1333998.M2A_2465	5.84e-61	192.0	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,2U73K@28211|Alphaproteobacteria,4BQH6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	MoaE protein	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
k59_178583_2	1045009.AFXQ01000011_gene473	8.54e-66	214.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria,1W8DV@1268|Micrococcaceae	201174|Actinobacteria	P	Belongs to the bacterial solute-binding protein 9 family	mntC	-	-	ko:K02077	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
k59_1117663_1	1049564.TevJSym_aq00060	5.5e-290	797.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1J4KI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_1117663_2	754477.Q7C_584	1.1e-26	108.0	2E42P@1|root,32YZ5@2|Bacteria,1N868@1224|Proteobacteria,1SCUM@1236|Gammaproteobacteria,4614K@72273|Thiotrichales	72273|Thiotrichales	S	Domain of unknown function (DUF4124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124
k59_1295361_2	765910.MARPU_05880	5.35e-32	120.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RPM1@1236|Gammaproteobacteria,1WW4Q@135613|Chromatiales	135613|Chromatiales	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_1587248_1	2340.JV46_03910	4.01e-57	193.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1J9TH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_237661_1	85643.Tmz1t_0359	6.12e-32	130.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VP9Y@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_3282_1	765913.ThidrDRAFT_4545	2.47e-214	599.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria,1X0JE@135613|Chromatiales	135613|Chromatiales	L	PFAM transposase mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_765390_1	743718.Isova_1302	6.12e-114	359.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4F476@85017|Promicromonosporaceae	201174|Actinobacteria	L	DNA polymerase alpha chain like domain	dnaE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_472106_1	237368.SCABRO_02371	1.35e-37	134.0	2CJ51@1|root,321BV@2|Bacteria	2|Bacteria	S	Gluconate 2-dehydrogenase subunit 3	-	-	-	-	-	-	-	-	-	-	-	-	Gluconate_2-dh3
k59_648229_1	880070.Cycma_4831	1.44e-18	92.8	COG3119@1|root,COG3119@2|Bacteria,4NEDH@976|Bacteroidetes,47U90@768503|Cytophagia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_1059500_1	880072.Desac_1037	1.84e-75	241.0	COG1304@1|root,COG2221@1|root,COG1304@2|Bacteria,COG2221@2|Bacteria	2|Bacteria	C	Nitrite and sulphite reductase 4Fe-4S	yahG	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_1033	DUF1116,FMN_dh,Fer4,Glu_synthase
k59_884470_1	335543.Sfum_2565	1.17e-117	358.0	COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria,2MQWJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit	-	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
k59_707032_1	1417296.U879_08070	3.24e-65	205.0	COG1150@1|root,COG1150@2|Bacteria,1R7PH@1224|Proteobacteria,2U2FE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
k59_707032_2	582899.Hden_0690	1.28e-08	55.8	COG2048@1|root,COG2048@2|Bacteria,1R97P@1224|Proteobacteria,2TSIB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_943182_1	344747.PM8797T_12343	3.7e-34	135.0	COG0841@1|root,COG0841@2|Bacteria,2IY0S@203682|Planctomycetes	203682|Planctomycetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1177365_2	190650.CC_3499	4.88e-05	47.8	2AA4J@1|root,30ZDH@2|Bacteria,1NKJ2@1224|Proteobacteria,2UK6J@28211|Alphaproteobacteria,2KJK0@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1824695_2	471853.Bcav_1972	2.98e-282	799.0	COG3280@1|root,COG3280@2|Bacteria,2GJTB@201174|Actinobacteria	201174|Actinobacteria	G	Malto-oligosyl trehalose synthase	treY	GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
k59_1529377_1	1026882.MAMP_01660	7.21e-97	285.0	COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,1S217@1236|Gammaproteobacteria,460FA@72273|Thiotrichales	72273|Thiotrichales	L	3'-to-5' exoribonuclease specific for small oligoribonucleotides	orn	-	-	ko:K13288	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	RNase_T
k59_1529377_2	187272.Mlg_1897	3.02e-11	62.4	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,1WYU5@135613|Chromatiales	135613|Chromatiales	P	PFAM Rhodanese domain protein	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_4392_1	1116472.MGMO_45c00480	4.29e-17	79.0	COG3415@1|root,COG3415@2|Bacteria,1QIVY@1224|Proteobacteria,1TGS2@1236|Gammaproteobacteria,1XGGU@135618|Methylococcales	135618|Methylococcales	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
k59_1587967_2	1123070.KB899258_gene1876	6.96e-51	173.0	COG0438@1|root,COG0438@2|Bacteria,46VHB@74201|Verrucomicrobia,2IVB9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_1824702_1	471853.Bcav_1158	4.1e-79	249.0	COG0026@1|root,COG0026@2|Bacteria,2GJCU@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
k59_649028_1	762903.Pedsa_1942	1.15e-34	132.0	COG0034@1|root,COG0034@2|Bacteria,4NFSM@976|Bacteroidetes,1INR4@117747|Sphingobacteriia	976|Bacteroidetes	F	Amidophosphoribosyltransferase	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7
k59_649028_2	546274.EIKCOROL_00722	9.51e-07	51.2	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2VIFF@28216|Betaproteobacteria,2KQ2S@206351|Neisseriales	206351|Neisseriales	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_1705723_1	1122137.AQXF01000002_gene650	2.22e-45	159.0	COG1757@1|root,COG1757@2|Bacteria,1MVDF@1224|Proteobacteria,2TU82@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Na H antiporter	-	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
k59_824821_1	1049564.TevJSym_aj00210	5.2e-150	451.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1J56C@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_531684_1	768671.ThimaDRAFT_2470	7.18e-43	149.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1WWP3@135613|Chromatiales	135613|Chromatiales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_1470823_2	903814.ELI_3010	1.12e-31	113.0	COG0389@1|root,COG0389@2|Bacteria,1VEU0@1239|Firmicutes,24RTW@186801|Clostridia,25X8G@186806|Eubacteriaceae	186801|Clostridia	L	Pathogenicity locus	-	-	-	-	-	-	-	-	-	-	-	-	Cdd1
k59_1470823_3	631362.Thi970DRAFT_00329	6.74e-23	95.9	COG3449@1|root,COG3449@2|Bacteria,1RF2U@1224|Proteobacteria,1S2JU@1236|Gammaproteobacteria,1WY8T@135613|Chromatiales	135613|Chromatiales	L	PFAM SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
k59_944393_1	1049564.TevJSym_aj00500	2.84e-56	191.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1J50Y@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0659 Sulfate permease and related transporters (MFS superfamily)	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1764200_1	1123487.KB892857_gene2468	7.5e-52	166.0	COG0346@1|root,COG0346@2|Bacteria,1N1D4@1224|Proteobacteria,2WE8C@28216|Betaproteobacteria,2KXNA@206389|Rhodocyclales	206389|Rhodocyclales	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
k59_1060303_1	388051.AUFE01000040_gene3244	1.53e-44	148.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2VR4P@28216|Betaproteobacteria	28216|Betaproteobacteria	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_1060303_2	472759.Nhal_0650	2.23e-54	177.0	COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1WWJB@135613|Chromatiales	135613|Chromatiales	E	PFAM Amino acid-binding ACT	-	-	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT_6
k59_944400_1	471853.Bcav_3730	8.78e-31	119.0	COG0014@1|root,COG0014@2|Bacteria,2GISA@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_824832_2	1123065.ATWL01000017_gene2034	1.12e-55	178.0	COG1695@1|root,COG1695@2|Bacteria,2GMJM@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
k59_357283_1	314278.NB231_08650	1.61e-132	414.0	COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1SYTD@1236|Gammaproteobacteria,1X2IM@135613|Chromatiales	135613|Chromatiales	EO	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M1,Peptidase_M28
k59_472918_1	156889.Mmc1_2139	4.1e-50	169.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TS46@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	dctP	-	-	ko:K11688	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
k59_472918_2	243233.MCA2024	7.63e-28	103.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1XF4G@135618|Methylococcales	135618|Methylococcales	J	endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_1587995_1	502025.Hoch_6478	1.3e-97	299.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42QTE@68525|delta/epsilon subdivisions,2WN61@28221|Deltaproteobacteria,2YUPI@29|Myxococcales	28221|Deltaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,rve
k59_1236152_1	1415779.JOMH01000001_gene1179	5.19e-128	392.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1X45Q@135614|Xanthomonadales	135614|Xanthomonadales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_63795_2	572477.Alvin_2888	1.04e-13	70.9	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1WVY3@135613|Chromatiales	135613|Chromatiales	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1296645_1	1232666.JANE01000107_gene23	7.73e-06	54.3	COG4412@1|root,COG4412@2|Bacteria,1TQYP@1239|Firmicutes,4HD82@91061|Bacilli,4GYWE@90964|Staphylococcaceae	91061|Bacilli	S	Immune inhibitor A peptidase M6	-	-	-	ko:K09607	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M6
k59_1764215_1	2340.JV46_13060	8.71e-46	158.0	COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,1RQ0T@1236|Gammaproteobacteria,1J5E5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	ldh	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_1177399_1	706587.Desti_2954	4.63e-94	293.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42MUH@68525|delta/epsilon subdivisions,2WJ16@28221|Deltaproteobacteria,2MR2Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Acyl-CoA dehydrogenase	-	-	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_1412241_2	391615.ABSJ01000052_gene1294	5.56e-79	251.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RR6H@1236|Gammaproteobacteria,1J7H4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_1647251_1	572477.Alvin_1192	1.31e-60	209.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales	135613|Chromatiales	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_1824777_1	1049564.TevJSym_ar00370	2.52e-37	137.0	COG1142@1|root,COG1142@2|Bacteria,1RIXA@1224|Proteobacteria,1SBMD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_414056_1	1304865.JAGF01000001_gene2835	6.19e-78	253.0	COG4987@1|root,COG4987@2|Bacteria,2H79B@201174|Actinobacteria,4F2A0@85016|Cellulomonadaceae	201174|Actinobacteria	CO	TIGRFAM ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC	cydC	-	-	ko:K06148,ko:K16012	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.129	-	-	ABC_membrane,ABC_tran
k59_1177407_1	335543.Sfum_3200	1.95e-141	413.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Q0C@68525|delta/epsilon subdivisions,2WIIZ@28221|Deltaproteobacteria,2MRB7@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986,ko:K15342	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	Cas_Cas1,GIIM,RVT_1
k59_1412247_1	1280390.CBQR020000100_gene2335	2.09e-81	247.0	COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,4HAVS@91061|Bacilli,26R6G@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the pseudouridine synthase RsuA family	rluF	-	5.4.99.21	ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_357321_1	1249627.D779_2750	1.39e-115	360.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWAU@135613|Chromatiales	135613|Chromatiales	U	Hydrophobe Amphiphile Efflux-1 (HAE1)	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_1769091_1	96561.Dole_0577	1.15e-63	204.0	COG1149@1|root,COG1149@2|Bacteria,1MVPB@1224|Proteobacteria,42MJ5@68525|delta/epsilon subdivisions,2WJ9M@28221|Deltaproteobacteria,2MIKP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	CobQ CobB MinD ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
k59_713244_1	1515746.HR45_17565	8.55e-19	92.8	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,2QB92@267890|Shewanellaceae	1236|Gammaproteobacteria	M	surface antigen variable number repeat protein	plpD	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k59_71313_1	926556.Echvi_0516	1.73e-10	61.6	COG3534@1|root,COG3534@2|Bacteria,4NECK@976|Bacteroidetes,47JK0@768503|Cytophagia	976|Bacteroidetes	G	Alpha-L-arabinofuranosidase C-terminus	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
k59_247818_1	1095767.CAHD01000213_gene595	3.16e-152	437.0	COG0391@1|root,COG0391@2|Bacteria,2GJBW@201174|Actinobacteria,4F21B@85016|Cellulomonadaceae	201174|Actinobacteria	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
k59_1067627_1	323261.Noc_1207	2.53e-96	291.0	28JVF@1|root,2Z9KD@2|Bacteria,1MXZ6@1224|Proteobacteria,1RY7E@1236|Gammaproteobacteria,1WX1M@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_713246_1	768671.ThimaDRAFT_1206	2.65e-79	257.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1WVZ6@135613|Chromatiales	135613|Chromatiales	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF3340,PDZ,Peptidase_S41
k59_893033_1	1297742.A176_01664	6.05e-05	50.1	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,42NXB@68525|delta/epsilon subdivisions,2WMBF@28221|Deltaproteobacteria,2YW82@29|Myxococcales	28221|Deltaproteobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
k59_595469_1	765912.Thimo_3151	1.9e-117	359.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWQV@135613|Chromatiales	135613|Chromatiales	L	it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction	rep	-	3.6.4.12	ko:K03656	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_595469_2	1042375.AFPL01000030_gene517	3.33e-21	85.9	COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,1S9Z9@1236|Gammaproteobacteria,46BQQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	cyc	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	Cytochrome_CBB3
k59_713248_1	649743.HMPREF0972_02212	3.48e-24	103.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4D3VH@85005|Actinomycetales	201174|Actinobacteria	IQ	cog cog0318	fadD2	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_713248_2	1177594.MIC448_680009	4.06e-29	114.0	COG0362@1|root,COG0362@2|Bacteria,2GJ2J@201174|Actinobacteria,4FMBW@85023|Microbacteriaceae	201174|Actinobacteria	G	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
k59_478188_1	1288079.AUKN01000019_gene2750	2.1e-89	270.0	COG1082@1|root,COG1082@2|Bacteria,2GJ6E@201174|Actinobacteria	201174|Actinobacteria	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
k59_770424_1	765910.MARPU_10245	3.86e-47	172.0	COG3614@1|root,COG5002@1|root,COG3614@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1RPI4@1236|Gammaproteobacteria,1X2S5@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,PAS_9
k59_770424_2	511062.GU3_02550	1.06e-45	151.0	COG0745@1|root,COG0745@2|Bacteria,1MZAS@1224|Proteobacteria,1S9XI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG0784 FOG CheY-like receiver	cheY-1	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_1358652_1	2340.JV46_07790	3.04e-60	202.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,1RZ0U@1236|Gammaproteobacteria,1JAJ9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Fumarate reductase flavoprotein C-term	aprA	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1418043_2	472759.Nhal_3926	5.52e-55	199.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1WWY6@135613|Chromatiales	135613|Chromatiales	U	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
k59_71329_1	269799.Gmet_2767	6.15e-115	354.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42Y60@68525|delta/epsilon subdivisions,2WUR1@28221|Deltaproteobacteria,43T95@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_1067639_1	670307.HYPDE_31343	1.37e-38	143.0	COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2TR6Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TIGRFAM 40-residue YVTN family beta-propeller repeat protein	MA20_34510	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
k59_419350_1	637390.AFOH01000044_gene2204	1.65e-46	160.0	COG3185@1|root,COG3185@2|Bacteria,1R5AJ@1224|Proteobacteria,1RY8F@1236|Gammaproteobacteria,2NCB5@225057|Acidithiobacillales	225057|Acidithiobacillales	E	4-Hydroxyphenylpyruvate dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_419350_2	1121448.DGI_1753	1.13e-99	298.0	COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,42PJM@68525|delta/epsilon subdivisions,2WKJN@28221|Deltaproteobacteria,2M970@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
k59_1243147_1	1265505.ATUG01000002_gene1477	8.69e-148	424.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,42NEN@68525|delta/epsilon subdivisions,2WKJP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1122768_1	1299327.I546_2510	7.46e-35	134.0	COG1020@1|root,COG1020@2|Bacteria,2GKGU@201174|Actinobacteria,23632@1762|Mycobacteriaceae	201174|Actinobacteria	Q	Wax ester synthase-like Acyl-CoA acyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
k59_1832388_1	545276.KB898724_gene1876	7.96e-144	435.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales	135613|Chromatiales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_1358658_1	1123368.AUIS01000006_gene673	1.03e-115	347.0	COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,1RMAV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Involved in arsenical resistance. Thought to form the channel of an arsenite pump	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_1832390_1	1049564.TevJSym_aj00290	1.93e-49	171.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1J4RF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the MurCDEF family	murC	GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iECP_1309.ECP_0093	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1478182_1	1207075.PputUW4_02307	2.79e-77	254.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Exporters of the RND superfamily	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
k59_1534617_1	1121405.dsmv_0691	5.91e-95	293.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales	68525|delta/epsilon subdivisions	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1418055_1	270374.MELB17_19199	2.46e-61	196.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,4655B@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009898,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_1418055_2	1000565.METUNv1_02959	9.67e-07	49.3	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2VIIR@28216|Betaproteobacteria,2KU8Q@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
k59_595489_1	1463861.JNXE01000042_gene6722	3.72e-50	176.0	290E5@1|root,2ZN3G@2|Bacteria,2IH3T@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1593004_1	367299.JOEE01000002_gene2420	3.09e-29	113.0	COG0156@1|root,COG0156@2|Bacteria,2GISV@201174|Actinobacteria,4FFJ8@85021|Intrasporangiaceae	201174|Actinobacteria	E	8-amino-7-oxononanoate synthase	bioF	-	2.3.1.47,6.2.1.14	ko:K00652,ko:K01906	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03209,R03210,R10124	RC00004,RC00014,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2,BioW
k59_654593_1	1116472.MGMO_83c00160	1.36e-141	416.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1XESH@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
k59_1478196_1	666509.RCA23_c27560	4.07e-17	80.1	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
k59_1478196_2	1411123.JQNH01000001_gene242	1.07e-44	154.0	COG0596@1|root,COG0596@2|Bacteria,1MUVB@1224|Proteobacteria,2TREP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Alpha beta hydrolase	MA20_05720	-	3.8.1.3	ko:K01561	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_830463_1	1167006.UWK_01948	5.84e-109	330.0	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,42KZP@68525|delta/epsilon subdivisions,2WKSV@28221|Deltaproteobacteria,2MHUQ@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,PAS
k59_1243175_1	246197.MXAN_0543	1.26e-68	224.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,437V8@68525|delta/epsilon subdivisions,2X34Q@28221|Deltaproteobacteria,2YU9A@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase dimerisation domain	dapE1	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_1122783_1	446469.Sked_07590	4.61e-23	95.9	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase M48B family	htpX	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
k59_1122783_2	446466.Cfla_2698	2.16e-27	110.0	COG0493@1|root,COG0493@2|Bacteria,2GJ4A@201174|Actinobacteria,4F0XV@85016|Cellulomonadaceae	201174|Actinobacteria	E	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	fprA	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	Pyr_redox_2
k59_1769124_1	1229780.BN381_430052	5.16e-35	132.0	COG2267@1|root,COG2267@2|Bacteria,2GYP0@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)	menH	-	4.2.99.20	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08166	RC02148,RC02475	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_6
k59_14176_1	754476.Q7A_1752	1.22e-55	182.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,1RMGB@1236|Gammaproteobacteria,462RD@72273|Thiotrichales	72273|Thiotrichales	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
k59_71372_1	1303518.CCALI_01191	4.66e-54	187.0	COG2804@1|root,COG2804@2|Bacteria	2|Bacteria	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
k59_952088_3	1121924.ATWH01000024_gene1052	4.06e-13	69.3	COG1848@1|root,COG1848@2|Bacteria,2GRA5@201174|Actinobacteria,4FSPB@85023|Microbacteriaceae	201174|Actinobacteria	S	PIN domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045926,GO:0048519,GO:0050789,GO:0065007,GO:0071944	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
k59_952088_4	1122138.AQUZ01000050_gene7786	1.67e-05	47.4	2BBGE@1|root,324ZT@2|Bacteria,2HA09@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
k59_247898_1	572477.Alvin_2539	1.17e-82	265.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WWSA@135613|Chromatiales	135613|Chromatiales	U	sulphate transporter	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_1418068_1	631362.Thi970DRAFT_03306	3.87e-80	261.0	COG0438@1|root,COG0438@2|Bacteria,1QZ01@1224|Proteobacteria,1RZJA@1236|Gammaproteobacteria,1X05E@135613|Chromatiales	135613|Chromatiales	M	sucrose synthase	-	-	2.4.1.13	ko:K00695	ko00500,ko01100,map00500,map01100	-	R00806	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glycos_transf_1,Sucrose_synth
k59_1832421_1	768671.ThimaDRAFT_0777	1.65e-145	424.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1WVW6@135613|Chromatiales	135613|Chromatiales	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_654606_1	631362.Thi970DRAFT_04199	2.11e-141	410.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1WWJU@135613|Chromatiales	135613|Chromatiales	H	PFAM Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_893096_1	1120983.KB894577_gene3673	1.01e-67	226.0	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the glycosyl hydrolase 3 family	bglX	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_1478214_1	864069.MicloDRAFT_00025770	1.72e-111	332.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2TQUS@28211|Alphaproteobacteria,1JRWP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
k59_893098_1	880072.Desac_0738	5.64e-63	204.0	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,42NAI@68525|delta/epsilon subdivisions,2WJYY@28221|Deltaproteobacteria,2MR3M@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.1.25,2.7.7.4	ko:K00958,ko:K13811	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
k59_1243191_1	1408164.MOLA814_01948	6.93e-68	218.0	COG0765@1|root,COG0765@2|Bacteria,1QN80@1224|Proteobacteria,2VKTN@28216|Betaproteobacteria,1KR0Q@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
k59_1832426_1	93612.XP_008024265.1	7.47e-06	53.5	COG4799@1|root,KOG0540@2759|Eukaryota,38D8D@33154|Opisthokonta,3NZJP@4751|Fungi,3QSK0@4890|Ascomycota,2005A@147541|Dothideomycetes,4KBUA@92860|Pleosporales	4751|Fungi	EI	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
k59_1832434_1	857087.Metme_3258	5.23e-52	186.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iSFV_1184.SFV_4025	PEPcase
k59_302123_1	765912.Thimo_0728	1.79e-07	51.2	COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,1RQIE@1236|Gammaproteobacteria,1WY1I@135613|Chromatiales	135613|Chromatiales	M	PFAM Outer membrane	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
k59_302123_2	187272.Mlg_2721	3.19e-19	88.6	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1WWER@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
k59_1710715_1	2340.JV46_14790	4.38e-107	317.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1J5D9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iAF1260.b1091,iAPECO1_1312.APECO1_172,iBWG_1329.BWG_0939,iE2348C_1286.E2348C_1183,iEC55989_1330.EC55989_1203,iECABU_c1320.ECABU_c13040,iECDH10B_1368.ECDH10B_1163,iECDH1ME8569_1439.ECDH1ME8569_1026,iECED1_1282.ECED1_1234,iECH74115_1262.ECH74115_1470,iECIAI39_1322.ECIAI39_2070,iECO103_1326.ECO103_1136,iECO111_1330.ECO111_1368,iECO26_1355.ECO26_1424,iECOK1_1307.ECOK1_1198,iECP_1309.ECP_1083,iECS88_1305.ECS88_1105,iECSP_1301.ECSP_1392,iECW_1372.ECW_m1199,iECs_1301.ECs1469,iEKO11_1354.EKO11_2743,iETEC_1333.ETEC_1156,iEcDH1_1363.EcDH1_2556,iEcE24377_1341.EcE24377A_1212,iEcSMS35_1347.EcSMS35_2036,iG2583_1286.G2583_1351,iJO1366.b1091,iJR904.b1091,iLF82_1304.LF82_0609,iNRG857_1313.NRG857_05260,iSSON_1240.SSON_1111,iSbBS512_1146.SbBS512_E2233,iUMN146_1321.UM146_11870,iUMNK88_1353.UMNK88_1361,iUTI89_1310.UTI89_C1216,iWFL_1372.ECW_m1199,iY75_1357.Y75_RS05700,iZ_1308.Z1730,ic_1306.c1360	ACP_syn_III,ACP_syn_III_C
k59_1710715_2	765911.Thivi_0015	1.6e-27	109.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1WW6R@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_14218_1	1121405.dsmv_1539	1.32e-64	204.0	28PW7@1|root,32EDN@2|Bacteria,1N0AP@1224|Proteobacteria,42UF5@68525|delta/epsilon subdivisions,2WQ2P@28221|Deltaproteobacteria,2MKES@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
k59_952115_1	1278078.G419_18101	3.52e-37	134.0	COG4285@1|root,COG4285@2|Bacteria,2GNQ0@201174|Actinobacteria,4G5CJ@85025|Nocardiaceae	201174|Actinobacteria	S	Biotin-protein ligase, N terminal	-	-	-	-	-	-	-	-	-	-	-	-	BPL_N
k59_952115_2	1463845.JOIG01000006_gene1133	1.45e-12	75.1	COG2311@1|root,COG2311@2|Bacteria,2GMWJ@201174|Actinobacteria	201174|Actinobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF418
k59_1005431_1	590998.Celf_0571	1.62e-47	164.0	COG0414@1|root,COG0414@2|Bacteria,2GJEQ@201174|Actinobacteria,4F0FR@85016|Cellulomonadaceae	201174|Actinobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
k59_1067710_1	1423144.Gal_00459	1.82e-88	273.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSG6@28211|Alphaproteobacteria,34EHW@302485|Phaeobacter	28211|Alphaproteobacteria	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_713321_1	1163617.SCD_n01156	2.98e-113	346.0	28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,2VKHA@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Cytochrome c bacterial	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_cB
k59_14229_2	686340.Metal_1807	1.05e-54	187.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1XECZ@135618|Methylococcales	135618|Methylococcales	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
k59_478257_1	1122599.AUGR01000004_gene2166	7.43e-102	306.0	COG1638@1|root,COG1638@2|Bacteria,1P574@1224|Proteobacteria,1S0S8@1236|Gammaproteobacteria,1XNVZ@135619|Oceanospirillales	135619|Oceanospirillales	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_126336_1	582899.Hden_2133	4.56e-73	239.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,3N6UZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	asparagine synthase (glutamine-hydrolyzing)	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_1243234_1	446469.Sked_27470	2.59e-117	365.0	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria	201174|Actinobacteria	T	UPF0182 protein	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_302141_1	1137799.GZ78_26765	2.37e-84	262.0	COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,1XHC5@135619|Oceanospirillales	135619|Oceanospirillales	E	alanine symporter	dagA	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_1183089_1	5911.EAR99658	1.55e-09	65.1	COG2074@1|root,2QR37@2759|Eukaryota,3ZBWF@5878|Ciliophora	5878|Ciliophora	G	myo-inositol hexakisphosphate metabolic process	-	-	-	ko:K05715	-	-	R02664	RC00002,RC00017	ko00000,ko01000	-	-	-	-
k59_893144_1	452637.Oter_1462	3.3e-49	170.0	COG0607@1|root,COG2391@1|root,COG0607@2|Bacteria,COG2391@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	2.8.1.1,2.8.1.2	ko:K00406,ko:K01011,ko:K07112	ko00190,ko00270,ko00920,ko01100,ko01120,ko02020,ko04122,map00190,map00270,map00920,map01100,map01120,map02020,map04122	M00156	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	PALP,Rhodanese,Sulf_transp
k59_893144_2	452637.Oter_1463	9.58e-63	197.0	COG2391@1|root,COG2391@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_1305180_1	448385.sce3234	7.72e-149	451.0	COG1061@1|root,COG3886@1|root,COG1061@2|Bacteria,COG3886@2|Bacteria,1MV9F@1224|Proteobacteria,42NS1@68525|delta/epsilon subdivisions,2WQXY@28221|Deltaproteobacteria,2YWZQ@29|Myxococcales	28221|Deltaproteobacteria	KL	Domain of unknown function (DUF3427)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3427,Helicase_C,PLDc_2,ResIII
k59_302711_1	1260251.SPISAL_07505	3.57e-86	283.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_831086_1	1037409.BJ6T_56200	7.2e-91	284.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2TU9Q@28211|Alphaproteobacteria,3JW1M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_713993_1	298386.PBPRA1265	3.45e-214	609.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,1RMHR@1236|Gammaproteobacteria,1XUC7@135623|Vibrionales	135623|Vibrionales	Q	COG2015 Alkyl sulfatase and related hydrolases	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_1535202_1	1304865.JAGF01000001_gene687	1.93e-125	383.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria,4F0E3@85016|Cellulomonadaceae	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1305201_1	768671.ThimaDRAFT_4258	1.44e-55	183.0	COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,1WY02@135613|Chromatiales	135613|Chromatiales	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
k59_1305201_2	768671.ThimaDRAFT_4259	1.3e-32	120.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,1WW0G@135613|Chromatiales	135613|Chromatiales	J	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
k59_249084_3	268739.Nmlp_1695	4.29e-67	250.0	COG0417@1|root,COG1372@1|root,arCOG00328@2157|Archaea,arCOG03145@2157|Archaea,2XU1K@28890|Euryarchaeota,23RXE@183963|Halobacteria	183963|Halobacteria	L	COG0417 DNA polymerase elongation subunit (family B)	polB1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1,Intein_splicing
k59_478851_1	493475.GARC_2471	3.1e-46	156.0	COG3339@1|root,COG3339@2|Bacteria,1RAN7@1224|Proteobacteria,1S291@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Conserved Protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
k59_249085_1	29581.BW37_03370	3.04e-22	95.1	COG1295@1|root,COG1295@2|Bacteria,1NH82@1224|Proteobacteria,2VJW7@28216|Betaproteobacteria,472BA@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Virulence factor BrkB	-	-	-	-	-	-	-	-	-	-	-	-	Virul_fac_BrkB
k59_836085_2	489825.LYNGBM3L_68850	1.92e-84	263.0	COG5433@1|root,COG5433@2|Bacteria,1G0VN@1117|Cyanobacteria,1H992@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_959827_1	643473.KB235930_gene3520	1.92e-16	86.7	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G1G5@1117|Cyanobacteria,1HIEQ@1161|Nostocales	1117|Cyanobacteria	K	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
k59_900860_1	903818.KI912268_gene2574	4.64e-21	87.8	COG1908@1|root,COG1908@2|Bacteria	2|Bacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	hdrG	-	-	-	-	-	-	-	-	-	-	-	FlpD
k59_1127563_1	1095767.CAHD01000030_gene1069	2.17e-72	226.0	COG0667@1|root,COG0667@2|Bacteria,2GMT5@201174|Actinobacteria,4F1VU@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM aldo keto reductase	-	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
k59_1127563_2	1449069.JMLO01000021_gene3008	1.09e-31	117.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4FW36@85025|Nocardiaceae	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	livF	-	-	ko:K01995,ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_1716048_1	944479.JQLX01000012_gene1156	6.76e-16	85.1	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,439VX@68525|delta/epsilon subdivisions,2X5A1@28221|Deltaproteobacteria,2M7IX@213113|Desulfurellales	28221|Deltaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1127565_1	204669.Acid345_2948	2.02e-35	131.0	COG1180@1|root,COG1180@2|Bacteria,3Y62D@57723|Acidobacteria	57723|Acidobacteria	O	Elongator protein 3, MiaB family, Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
k59_79001_1	1209984.BN978_05869	1.09e-25	106.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,233WJ@1762|Mycobacteriaceae	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_718956_1	1108045.GORHZ_053_00480	5.76e-151	451.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4GCPV@85026|Gordoniaceae	201174|Actinobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_900873_1	367299.JOEE01000010_gene3357	3.6e-82	245.0	299E4@1|root,2ZWGX@2|Bacteria,2GM90@201174|Actinobacteria,4FGEC@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3145)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3145
k59_79002_1	471853.Bcav_2313	3.51e-93	286.0	COG0330@1|root,COG0330@2|Bacteria,2GJ1U@201174|Actinobacteria	201174|Actinobacteria	O	PFAM Band 7 protein	hflK	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7
k59_600760_1	572477.Alvin_1194	5.73e-17	78.2	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,1WY36@135613|Chromatiales	135613|Chromatiales	E	PFAM lipolytic protein G-D-S-L family	-	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
k59_600760_2	1316927.ATKI01000043_gene2927	7.05e-22	92.4	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1YPAU@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner	lolD	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051234,GO:0051641,GO:0055085,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0097159,GO:0097367,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1990778	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
k59_900883_1	246437.XP_006142868.1	1.86e-14	72.8	COG1028@1|root,KOG4170@1|root,KOG0725@2759|Eukaryota,KOG4170@2759|Eukaryota,38DZE@33154|Opisthokonta,3BA0D@33208|Metazoa,3CVGY@33213|Bilateria,480GA@7711|Chordata,49406@7742|Vertebrata,3JAEH@40674|Mammalia,35N2F@314146|Euarchontoglires	33208|Metazoa	Q	oxidoreductase activity	HSDL2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	SCP2,adh_short
k59_900883_2	1268635.Loa_01656	2.88e-21	94.7	COG0586@1|root,COG0671@1|root,COG0586@2|Bacteria,COG0671@2|Bacteria,1R0F3@1224|Proteobacteria,1RPDS@1236|Gammaproteobacteria,1JCZX@118969|Legionellales	118969|Legionellales	I	LssY C-terminus	lssY	-	-	-	-	-	-	-	-	-	-	-	LssY_C,PAP2,SNARE_assoc
k59_1076548_1	367299.JOEE01000004_gene1066	5.57e-98	305.0	COG0272@1|root,COG0272@2|Bacteria,2GJUY@201174|Actinobacteria,4FE3B@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
k59_1250943_1	240016.ABIZ01000001_gene1742	2.4e-62	208.0	COG1861@1|root,COG1861@2|Bacteria,46UVT@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_718968_1	479431.Namu_1913	1.15e-77	242.0	COG0371@1|root,COG0371@2|Bacteria,2GKWA@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase	gldA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
k59_959859_1	29495.EA26_03250	4.73e-64	220.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1XSNU@135623|Vibrionales	135623|Vibrionales	F	Carbamoyl-phosphate synthetase ammonia chain	carB	GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_836107_1	1122194.AUHU01000005_gene980	7.1e-41	144.0	COG0406@1|root,COG0406@2|Bacteria,1RHAT@1224|Proteobacteria,1S69R@1236|Gammaproteobacteria,46854@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Phosphoglycerate mutase	cobC	-	3.1.3.73,5.4.2.12	ko:K02226,ko:K15634	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00122	R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
k59_836107_2	640081.Dsui_0539	7.77e-38	139.0	COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,2VJ7T@28216|Betaproteobacteria,2KU8W@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC-type Fe3 -hydroxamate transport system, periplasmic component	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
k59_1423816_2	1415780.JPOG01000001_gene1823	2.49e-35	129.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1S4HN@1236|Gammaproteobacteria,1X9SZ@135614|Xanthomonadales	135614|Xanthomonadales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_1485955_1	396588.Tgr7_1272	1.44e-31	112.0	COG0298@1|root,COG0298@2|Bacteria,1QKV6@1224|Proteobacteria,1SE6V@1236|Gammaproteobacteria,1WZDC@135613|Chromatiales	135613|Chromatiales	O	PFAM hydrogenase expression formation protein (HUPF HYPC)	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
k59_1485955_2	765914.ThisiDRAFT_1290	2.18e-42	142.0	COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,1S5WG@1236|Gammaproteobacteria,1WYQN@135613|Chromatiales	135613|Chromatiales	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
k59_1485955_3	768671.ThimaDRAFT_2617	7.38e-55	180.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RN9Y@1236|Gammaproteobacteria,1WWGI@135613|Chromatiales	135613|Chromatiales	KO	TIGRFAM Hydrogenase accessory protein HypB	-	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
k59_836111_1	331869.BAL199_06569	2.75e-87	263.0	COG0421@1|root,COG0421@2|Bacteria,1QUUH@1224|Proteobacteria,2TW88@28211|Alphaproteobacteria,4BRWR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Spermidine synthase	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
k59_900897_1	1336243.JAEA01000017_gene557	1.45e-53	173.0	COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,2U79D@28211|Alphaproteobacteria,1JUHP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
k59_1312069_2	1117314.PCIT_13179	4.66e-12	70.1	COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,1RNM4@1236|Gammaproteobacteria,2Q3ID@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
k59_1077153_1	767029.HMPREF9154_2049	2.81e-08	54.3	COG0040@1|root,COG0040@2|Bacteria,2GNAX@201174|Actinobacteria	201174|Actinobacteria	E	ATP phosphoribosyltransferase	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
k59_1077153_2	177437.HRM2_35930	3.08e-39	141.0	COG1899@1|root,COG1899@2|Bacteria,1R3WQ@1224|Proteobacteria,42M57@68525|delta/epsilon subdivisions,2WJ6N@28221|Deltaproteobacteria,2MHW7@213118|Desulfobacterales	28221|Deltaproteobacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_257438_1	631362.Thi970DRAFT_03306	6.8e-86	276.0	COG0438@1|root,COG0438@2|Bacteria,1QZ01@1224|Proteobacteria,1RZJA@1236|Gammaproteobacteria,1X05E@135613|Chromatiales	135613|Chromatiales	M	sucrose synthase	-	-	2.4.1.13	ko:K00695	ko00500,ko01100,map00500,map01100	-	R00806	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glycos_transf_1,Sucrose_synth
k59_132535_2	1124780.ANNU01000051_gene2089	6.32e-27	100.0	COG3530@1|root,COG3530@2|Bacteria,4NUSP@976|Bacteroidetes,47RWJ@768503|Cytophagia	976|Bacteroidetes	S	Putative quorum-sensing-regulated virulence factor	-	-	-	ko:K09954	-	-	-	-	ko00000	-	-	-	QSregVF_b
k59_23781_1	794903.OPIT5_02785	8.39e-57	194.0	2C3QV@1|root,2Z7YP@2|Bacteria,46X55@74201|Verrucomicrobia,3K9QR@414999|Opitutae	414999|Opitutae	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
k59_1716522_1	71421.HI_1578	1.57e-11	68.2	COG1216@1|root,COG1216@2|Bacteria,1RDAK@1224|Proteobacteria,1S5S5@1236|Gammaproteobacteria,1Y94N@135625|Pasteurellales	135625|Pasteurellales	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_1486475_1	518766.Rmar_2140	1.48e-57	190.0	COG3676@1|root,COG3677@1|root,COG3676@2|Bacteria,COG3677@2|Bacteria,4NS7V@976|Bacteroidetes	976|Bacteroidetes	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_1010329_1	472759.Nhal_1059	5.81e-25	100.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1S48C@1236|Gammaproteobacteria,1X28M@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_1010329_2	1033802.SSPSH_001119	1.17e-31	117.0	COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,1RPT7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	Z012_09465	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_425364_1	225937.HP15_1821	2.28e-86	270.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,464VT@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0003674,GO:0003824,GO:0004044,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0034654,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iAF1260.b2312,iB21_1397.B21_02197,iBWG_1329.BWG_2086,iECBD_1354.ECBD_1347,iECB_1328.ECB_02237,iECDH10B_1368.ECDH10B_2474,iECDH1ME8569_1439.ECDH1ME8569_2250,iECD_1391.ECD_02237,iECIAI1_1343.ECIAI1_2389,iECO103_1326.ECO103_2776,iECO111_1330.ECO111_3060,iECO26_1355.ECO26_3300,iECW_1372.ECW_m2501,iEKO11_1354.EKO11_1453,iETEC_1333.ETEC_2448,iEcDH1_1363.EcDH1_1344,iEcE24377_1341.EcE24377A_2606,iEcolC_1368.EcolC_1340,iJO1366.b2312,iJR904.b2312,iSF_1195.SF2388,iSFxv_1172.SFxv_2633,iSSON_1240.SSON_2370,iS_1188.S2523,iSbBS512_1146.SbBS512_E2690,iUMNK88_1353.UMNK88_2863,iWFL_1372.ECW_m2501,iY75_1357.Y75_RS12125	GATase_6,Pribosyltran
k59_1659117_1	335543.Sfum_1473	1.57e-73	233.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,42MJA@68525|delta/epsilon subdivisions,2WJBJ@28221|Deltaproteobacteria,2MR0D@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
k59_542936_1	1121924.ATWH01000008_gene744	6.95e-39	144.0	COG1680@1|root,COG1680@2|Bacteria,2GNNF@201174|Actinobacteria,4FQWM@85023|Microbacteriaceae	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
k59_901528_2	43179.ENSSTOP00000003687	8.79e-24	99.8	COG1331@1|root,KOG2244@2759|Eukaryota,38VM1@33154|Opisthokonta,3BDEY@33208|Metazoa,3CTDG@33213|Bilateria,489FR@7711|Chordata,4910U@7742|Vertebrata,3J43A@40674|Mammalia,35MA4@314146|Euarchontoglires,4PZFV@9989|Rodentia	33208|Metazoa	O	Spermatogenesis-associated protein 20	SPATA20	GO:0000003,GO:0007276,GO:0007283,GO:0008150,GO:0019953,GO:0022414,GO:0032501,GO:0032504,GO:0044703,GO:0048232,GO:0048609,GO:0051704	-	-	-	-	-	-	-	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
k59_1659118_1	367299.JOEE01000004_gene1024	1.78e-60	189.0	COG1846@1|root,COG1846@2|Bacteria,2GKZA@201174|Actinobacteria,4FFNF@85021|Intrasporangiaceae	201174|Actinobacteria	K	MarR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
k59_1659118_2	196162.Noca_3420	8.89e-66	207.0	COG0637@1|root,COG0637@2|Bacteria,2I2IT@201174|Actinobacteria,4DN96@85009|Propionibacteriales	201174|Actinobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Hydrolase
k59_1424262_1	1454010.JEOE01000042_gene2866	2.67e-38	134.0	COG0047@1|root,COG0047@2|Bacteria,2GMJY@201174|Actinobacteria,4F12Y@85016|Cellulomonadaceae	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
k59_1424262_2	1304865.JAGF01000001_gene962	1.99e-38	131.0	COG1828@1|root,COG1828@2|Bacteria,2GQV4@201174|Actinobacteria,4F2UN@85016|Cellulomonadaceae	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
k59_1189275_1	1172188.KB911820_gene2420	1.73e-24	105.0	COG1501@1|root,COG1501@2|Bacteria,2GP4V@201174|Actinobacteria,4FG4A@85021|Intrasporangiaceae	201174|Actinobacteria	G	Glycosyl hydrolases family 31	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
k59_719448_1	1279019.ARQK01000038_gene1907	2.84e-108	320.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,1WWRH@135613|Chromatiales	135613|Chromatiales	G	Fructose-bisphosphate aldolase, class II, Calvin cycle subtype	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
k59_1077178_1	1049564.TevJSym_ap00680	1.83e-251	706.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1J4WR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_775387_1	443143.GM18_4037	2.53e-50	181.0	COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,42T0V@68525|delta/epsilon subdivisions,2WPRT@28221|Deltaproteobacteria,43TPS@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
k59_601245_1	1255043.TVNIR_1549	5.21e-152	468.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales	135613|Chromatiales	E	glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_1716544_1	671143.DAMO_2072	3.34e-13	74.3	COG1075@1|root,COG4995@1|root,COG1075@2|Bacteria,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,NB-ARC,TPR_12
k59_308010_1	62928.azo2621	7.78e-79	239.0	COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,2VSHT@28216|Betaproteobacteria,2KWE3@206389|Rhodocyclales	206389|Rhodocyclales	S	Bacterial protein of unknown function (DUF924)	-	-	-	-	-	-	-	-	-	-	-	-	DUF924
k59_1486493_1	765911.Thivi_3311	1.04e-07	51.6	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1WX8T@135613|Chromatiales	135613|Chromatiales	K	Belongs to the UPF0301 (AlgH) family	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_1486493_2	1049564.TevJSym_bn00090	2.45e-64	211.0	COG0810@1|root,COG0810@2|Bacteria,1R330@1224|Proteobacteria,1RQAX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Periplasmic protein TonB links inner and outer membranes	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
k59_1486493_3	519989.ECTPHS_03879	1.12e-37	135.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1WVY1@135613|Chromatiales	135613|Chromatiales	HJ	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
k59_1189292_1	1380391.JIAS01000011_gene5351	1.52e-06	50.4	COG3087@1|root,COG3087@2|Bacteria,1QW4V@1224|Proteobacteria,2TXJ8@28211|Alphaproteobacteria,2JZR2@204441|Rhodospirillales	204441|Rhodospirillales	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
k59_308021_1	1049564.TevJSym_aa01890	2.78e-95	293.0	COG0699@1|root,COG0699@2|Bacteria,1MV59@1224|Proteobacteria,1RYGW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_191213_1	234267.Acid_0692	1.51e-65	211.0	COG0714@1|root,COG0714@2|Bacteria,3Y4G8@57723|Acidobacteria	57723|Acidobacteria	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k59_1251513_1	411154.GFO_0311	2.29e-19	85.1	COG0589@1|root,COG0589@2|Bacteria,4NNMW@976|Bacteroidetes,1IIQF@117743|Flavobacteriia	976|Bacteroidetes	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_79775_2	35754.JNYJ01000045_gene4020	4.45e-28	112.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4DANT@85008|Micromonosporales	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_1659154_1	28072.Nos7524_1286	3.74e-10	67.4	COG2931@1|root,COG3210@1|root,COG3291@1|root,COG3595@1|root,COG4070@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG3595@2|Bacteria,COG4070@2|Bacteria,1GHDQ@1117|Cyanobacteria,1HUA0@1161|Nostocales	1117|Cyanobacteria	Q	Domain of unknown function (DUF4114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114
k59_836596_1	631362.Thi970DRAFT_01121	3.34e-79	246.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,1WXTC@135613|Chromatiales	135613|Chromatiales	L	transposase IS116 IS110 IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_23834_1	1122197.ATWI01000008_gene2680	4.16e-42	152.0	COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria,1S5IS@1236|Gammaproteobacteria,46B06@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_425416_1	1366050.N234_36085	1.3e-124	363.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria,1K2WH@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Elements of external origin	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_23,HTH_32
k59_1840977_1	1267005.KB911255_gene2534	1.39e-46	162.0	COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,2TQT2@28211|Alphaproteobacteria,3N6XJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1840977_2	591001.Acfer_1886	9.62e-05	43.9	COG0019@1|root,COG0019@2|Bacteria,1TPQI@1239|Firmicutes,4H3J8@909932|Negativicutes	909932|Negativicutes	E	carboxynorspermidine decarboxylase	nspC	-	4.1.1.96	ko:K13747	ko00330,ko01100,map00330,map01100	-	R09081,R09082	RC00299	ko00000,ko00001,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_308047_1	754436.JCM19237_2844	2.34e-147	432.0	COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,1RP89@1236|Gammaproteobacteria,1XTBK@135623|Vibrionales	135623|Vibrionales	H	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016153,GO:0016829,GO:0016835,GO:0016836,GO:0019439,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0052803,GO:0052805,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
k59_601273_1	2340.JV46_02810	1.73e-100	303.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,1J5JA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_601273_2	713586.KB900536_gene477	1.35e-196	552.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1WWHV@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_601273_3	1026882.MAMP_01993	6.29e-87	281.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,45ZYT@72273|Thiotrichales	72273|Thiotrichales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_191237_1	103690.17131947	5.19e-23	96.7	COG1087@1|root,COG1087@2|Bacteria,1G2HG@1117|Cyanobacteria,1HMNU@1161|Nostocales	1117|Cyanobacteria	M	Male sterility protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
k59_484210_1	187272.Mlg_2810	1.81e-100	308.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1WWQB@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
k59_1840979_1	1049564.TevJSym_au00160	1.16e-71	233.0	COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,1J4XK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB	hscA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051604,GO:0051716,GO:0070417,GO:0071704,GO:0097159,GO:0097367,GO:0097428,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1990230,GO:1990234	-	ko:K04044	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
k59_79798_1	944547.ABLL_1482	1.58e-52	174.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,42N0U@68525|delta/epsilon subdivisions,2YN7B@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
k59_79798_2	1038858.AXBA01000032_gene2594	1.56e-24	101.0	COG0671@1|root,COG0671@2|Bacteria,1RDK3@1224|Proteobacteria,2U7BJ@28211|Alphaproteobacteria,3EZ9R@335928|Xanthobacteraceae	28211|Alphaproteobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
k59_23850_1	376733.IT41_19790	3.38e-113	338.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2PW8K@265|Paracoccus	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_960586_1	367299.JOEE01000004_gene1191	8.17e-104	306.0	COG0052@1|root,COG0052@2|Bacteria,2GMYC@201174|Actinobacteria,4FE94@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_601276_1	398578.Daci_0116	1.08e-64	210.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VKC7@28216|Betaproteobacteria,4ABMY@80864|Comamonadaceae	28216|Betaproteobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	tdcB	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_4,PALP
k59_268168_1	519989.ECTPHS_03879	9.52e-70	221.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1WVY1@135613|Chromatiales	135613|Chromatiales	HJ	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
k59_1371286_1	1255043.TVNIR_0253	1.94e-47	162.0	COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,1WWM6@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator	-	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
k59_911234_1	566466.NOR53_1406	5.92e-21	90.9	COG2863@1|root,COG2863@2|Bacteria,1N7NU@1224|Proteobacteria,1SH3Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_843347_1	1335757.SPICUR_01180	2.29e-111	328.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,1RMFR@1236|Gammaproteobacteria,1WWRE@135613|Chromatiales	135613|Chromatiales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
k59_1260214_1	446466.Cfla_3402	7.96e-209	590.0	COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria,4F0KB@85016|Cellulomonadaceae	201174|Actinobacteria	G	PFAM ABC transporter related	-	-	3.6.3.17	ko:K10548	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.5	-	-	ABC_tran
k59_608130_1	232346.JHQL01000007_gene1909	1.98e-25	106.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,1XI99@135619|Oceanospirillales	135619|Oceanospirillales	L	glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
k59_608130_2	159450.NH14_21275	6.81e-26	97.1	COG2924@1|root,COG2924@2|Bacteria,1MZ2V@1224|Proteobacteria,2VTYU@28216|Betaproteobacteria,1K8DB@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes	yggX	-	-	-	-	-	-	-	-	-	-	-	Iron_traffic
k59_1431176_1	765912.Thimo_0459	1e-42	152.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1WVZP@135613|Chromatiales	135613|Chromatiales	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_1085933_1	187272.Mlg_1388	6.72e-44	163.0	COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,1RPGN@1236|Gammaproteobacteria,1X17T@135613|Chromatiales	135613|Chromatiales	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1085933_2	765913.ThidrDRAFT_2298	2.54e-78	254.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria,1WWE4@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	HlyD_D23
k59_315022_1	926569.ANT_10490	5.22e-49	175.0	28J5T@1|root,2Z91J@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_725851_1	330084.JNYZ01000006_gene1286	1.1e-103	315.0	COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria,4DX8R@85010|Pseudonocardiales	201174|Actinobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
k59_725851_2	224914.BMEI0025	0.000271	42.7	COG2303@1|root,COG2303@2|Bacteria,1MUK2@1224|Proteobacteria,2U08V@28211|Alphaproteobacteria,1J2DA@118882|Brucellaceae	28211|Alphaproteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N,NAD_binding_8
k59_667413_1	1193181.BN10_590051	8.18e-130	390.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4FECQ@85021|Intrasporangiaceae	201174|Actinobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_1666048_1	644282.Deba_2226	2.56e-84	280.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
k59_1371301_1	1232437.KL661985_gene3562	2.72e-84	256.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,42NK5@68525|delta/epsilon subdivisions,2WJ49@28221|Deltaproteobacteria,2MJA7@213118|Desulfobacterales	28221|Deltaproteobacteria	H	PBP superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	PBP_like_2
k59_1431182_1	471853.Bcav_3251	6.22e-59	194.0	COG0755@1|root,COG0755@2|Bacteria,2GJR1@201174|Actinobacteria	201174|Actinobacteria	O	cytochrome C	ccsB	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
k59_89439_1	338963.Pcar_0588	1.98e-86	264.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2WJI2@28221|Deltaproteobacteria,43S5S@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_1085951_1	1234364.AMSF01000098_gene2644	6.03e-79	248.0	28PII@1|root,2ZC8H@2|Bacteria,1R6MG@1224|Proteobacteria,1RZZF@1236|Gammaproteobacteria,1X769@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF4255)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4255
k59_549461_1	247490.KSU1_C1443	5.65e-32	126.0	COG1234@1|root,COG1234@2|Bacteria,2J27A@203682|Planctomycetes	203682|Planctomycetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_667423_1	768671.ThimaDRAFT_2811	2.85e-147	431.0	COG1288@1|root,COG1288@2|Bacteria,1MY1J@1224|Proteobacteria,1RS2M@1236|Gammaproteobacteria,1WZ5S@135613|Chromatiales	135613|Chromatiales	S	PFAM C4-dicarboxylate anaerobic	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
k59_383010_1	1197706.AKKK01000013_gene1966	1.31e-61	215.0	COG0739@1|root,COG3210@1|root,COG0739@2|Bacteria,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	CHB_HEX_C_1,Calx-beta,Laminin_G_3,PD40,Trypsin,VCBS
k59_1723441_1	880072.Desac_2355	7.73e-90	273.0	COG0826@1|root,COG0826@2|Bacteria,1N4QJ@1224|Proteobacteria,42YJR@68525|delta/epsilon subdivisions,2WUQ1@28221|Deltaproteobacteria,2MR6V@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Peptidase family U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
k59_1016077_1	471856.Jden_2081	1.38e-92	280.0	COG0573@1|root,COG0573@2|Bacteria,2GJDA@201174|Actinobacteria	201174|Actinobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_911277_1	1479237.JMLY01000001_gene389	1.85e-09	58.5	COG0596@1|root,COG0596@2|Bacteria,1QIT9@1224|Proteobacteria,1RNP9@1236|Gammaproteobacteria,469GQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_911277_2	887898.HMPREF0551_1085	1.9e-37	133.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2VUIT@28216|Betaproteobacteria,1KFF2@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
k59_911279_1	1123355.JHYO01000030_gene359	3.08e-55	177.0	COG1142@1|root,COG1142@2|Bacteria,1QWC6@1224|Proteobacteria,2TXIR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00196,ko:K05796	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	-	R07157,R08034	RC00250,RC02800	ko00000,ko00001	-	-	-	Fer4_4,Fer4_9
k59_911279_2	426114.THI_3176	1.56e-17	81.3	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,2VJ8P@28216|Betaproteobacteria,1KJ1B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	aorA	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
k59_725872_1	1279017.AQYJ01000029_gene3354	1.87e-37	142.0	COG3203@1|root,COG3203@2|Bacteria	2|Bacteria	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	ko:K09476	ko01501,ko02020,map01501,map02020	M00746	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.1.1.1	-	-	Porin_4
k59_432082_1	472759.Nhal_2491	3.95e-168	506.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,1RMSH@1236|Gammaproteobacteria,1WY9K@135613|Chromatiales	135613|Chromatiales	G	alpha amylase catalytic	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
k59_1016080_1	1454010.JEOE01000006_gene2141	3.68e-38	137.0	COG0039@1|root,COG0039@2|Bacteria,2GN5S@201174|Actinobacteria,4F1NU@85016|Cellulomonadaceae	201174|Actinobacteria	C	Belongs to the LDH MDH superfamily. LDH family	ldh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
k59_1016080_2	935839.JAGJ01000007_gene3175	7.37e-113	345.0	COG1199@1|root,COG1199@2|Bacteria,2GKT8@201174|Actinobacteria,4F3AC@85017|Promicromonosporaceae	201174|Actinobacteria	KL	HELICc2	dinG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
k59_1850744_2	511062.GU3_06650	5.6e-15	77.4	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria,1Y439@135624|Aeromonadales	135624|Aeromonadales	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
k59_268251_1	83219.PM02_17280	1.82e-17	81.6	COG1028@1|root,COG1028@2|Bacteria,1MWGC@1224|Proteobacteria,2TSNX@28211|Alphaproteobacteria,3ZV8K@60136|Sulfitobacter	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k59_383030_1	926560.KE387023_gene2467	3.42e-33	132.0	COG2202@1|root,COG4585@1|root,COG2202@2|Bacteria,COG4585@2|Bacteria,1WM3F@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3,PAS_4
k59_970318_1	396595.TK90_0985	1.4e-39	150.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WXY0@135613|Chromatiales	135613|Chromatiales	P	Sulfate transporter antisigma-factor antagonist STAS	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
k59_1723452_1	1267005.KB911260_gene3428	2.67e-124	364.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,2TRJK@28211|Alphaproteobacteria,3N6TA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Glycosyl hydrolase family 3 N terminal domain	nagZ	-	3.2.1.21,3.2.1.52	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	M00628	R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000	-	GH3	-	Glyco_hydro_3
k59_843381_1	1499967.BAYZ01000181_gene4486	3.42e-26	113.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,2NQ3X@2323|unclassified Bacteria	2|Bacteria	C	Domain of unknown function (DUF4445)	nqrF	GO:0005575,GO:0005622,GO:0005623,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0046858	-	ko:K04755,ko:K08952,ko:K08953,ko:K08954	-	-	-	-	ko00000,ko00194	-	-	-	DUF4445,Fer2
k59_725878_1	118168.MC7420_2791	1.73e-79	253.0	COG4313@1|root,COG4313@2|Bacteria,1G150@1117|Cyanobacteria	1117|Cyanobacteria	C	Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
k59_34638_2	1046724.KB889828_gene2913	7.22e-09	56.2	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,464H0@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
k59_1431205_1	396588.Tgr7_2405	2.76e-95	291.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1WX6G@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_268268_1	523791.Kkor_0338	8.55e-24	94.4	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,1S3QR@1236|Gammaproteobacteria,1XJUJ@135619|Oceanospirillales	135619|Oceanospirillales	O	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
k59_268268_2	1379698.RBG1_1C00001G1725	8.02e-11	63.2	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	acrD	-	-	ko:K03296,ko:K18138,ko:K18307	ko01501,ko01503,ko02024,map01501,map01503,map02024	M00644,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.20,2.A.6.2.32	-	-	ACR_tran
k59_1371327_1	1042377.AFPJ01000029_gene543	7.79e-05	48.1	COG4970@1|root,COG4970@2|Bacteria,1N0X8@1224|Proteobacteria,1SBSV@1236|Gammaproteobacteria,4695A@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	Type II transport protein GspH	fimT	-	-	ko:K08084	-	-	-	-	ko00000,ko02044	3.A.15.2	-	-	GspH,N_methyl
k59_89486_1	931626.Awo_c33550	6.25e-44	163.0	COG4631@1|root,COG4631@2|Bacteria,1UNCC@1239|Firmicutes,25H0U@186801|Clostridia	186801|Clostridia	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.17.1.4	ko:K13482	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_268271_1	675812.VHA_003463	4.77e-43	159.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1XTG6@135623|Vibrionales	135623|Vibrionales	I	COG1960 Acyl-CoA dehydrogenases	fadE	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N,DUF1974
k59_268272_1	1122194.AUHU01000003_gene2385	2.6e-80	258.0	COG0471@1|root,COG3273@1|root,COG0471@2|Bacteria,COG3273@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,465YV@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
k59_383051_2	1056816.JAFQ01000004_gene3759	9.09e-10	54.7	COG0211@1|root,COG0211@2|Bacteria,2IQDI@201174|Actinobacteria,4G21U@85025|Nocardiaceae	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
k59_1260294_1	519989.ECTPHS_10686	3.45e-40	143.0	COG1280@1|root,COG1280@2|Bacteria,1RF18@1224|Proteobacteria,1S4TM@1236|Gammaproteobacteria,1WYI1@135613|Chromatiales	135613|Chromatiales	E	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
k59_34679_1	765911.Thivi_3664	2.83e-27	108.0	COG2930@1|root,COG2930@2|Bacteria,1RCH3@1224|Proteobacteria,1S4XS@1236|Gammaproteobacteria,1WYED@135613|Chromatiales	135613|Chromatiales	S	(twin-arginine translocation) pathway signal	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1852321_2	1040983.AXAE01000025_gene4654	5.65e-50	160.0	COG3436@1|root,COG3436@2|Bacteria,1MZFT@1224|Proteobacteria,2U7MB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	PFAM IS66 Orf2 family protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
k59_781914_1	471853.Bcav_2897	3.23e-153	451.0	COG0210@1|root,COG0210@2|Bacteria,2GKRW@201174|Actinobacteria	201174|Actinobacteria	L	DNA helicase	uvrD2	GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HRDC,UvrD-helicase,UvrD_C
k59_1324051_1	933262.AXAM01000008_gene1971	1.79e-112	334.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,42M7H@68525|delta/epsilon subdivisions,2WIT7@28221|Deltaproteobacteria,2MI2A@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_3528	Seryl_tRNA_N,tRNA-synt_2b
k59_1782550_1	1006006.Mcup_1993	2.43e-24	100.0	COG1491@1|root,arCOG04130@2157|Archaea,2XQPC@28889|Crenarchaeota	28889|Crenarchaeota	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
k59_140062_1	583355.Caka_2358	1.73e-59	199.0	COG3137@1|root,COG3137@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
k59_1197083_1	290398.Csal_2062	1.77e-70	234.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1XH5W@135619|Oceanospirillales	135619|Oceanospirillales	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_971902_1	314345.SPV1_14149	6.91e-45	153.0	COG1392@1|root,COG1392@2|Bacteria,1NDTG@1224|Proteobacteria	1224|Proteobacteria	P	phosphate transport regulator (Distant homolog of PhoU)	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_1197085_1	765911.Thivi_0061	1.1e-93	294.0	COG0589@1|root,COG0730@1|root,COG0589@2|Bacteria,COG0730@2|Bacteria,1NBKV@1224|Proteobacteria,1SHMY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Universal stress protein family	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE,Usp
k59_1261348_1	1380354.JIAN01000006_gene506	1.07e-135	409.0	COG1198@1|root,COG1198@2|Bacteria,2GKES@201174|Actinobacteria,4F24Z@85016|Cellulomonadaceae	201174|Actinobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
k59_432988_1	367299.JOEE01000007_gene4	2.29e-70	220.0	COG1714@1|root,COG1714@2|Bacteria,2H4MP@201174|Actinobacteria,4FGD1@85021|Intrasporangiaceae	201174|Actinobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
k59_1087160_1	466088.CL42_13125	5.11e-06	50.1	COG1399@1|root,COG1399@2|Bacteria,1PGKW@1224|Proteobacteria,1SWVA@1236|Gammaproteobacteria,3NIVY@468|Moraxellaceae	1236|Gammaproteobacteria	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
k59_1372120_1	314278.NB231_15833	4.82e-54	183.0	COG4424@1|root,COG4424@2|Bacteria,1RGI6@1224|Proteobacteria,1S85X@1236|Gammaproteobacteria,1X13Z@135613|Chromatiales	135613|Chromatiales	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
k59_668316_1	926569.ANT_26670	3.12e-105	320.0	COG0459@1|root,COG0459@2|Bacteria,2G65N@200795|Chloroflexi	200795|Chloroflexi	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_912881_1	1448389.BAVQ01000035_gene789	5.39e-22	93.6	COG4447@1|root,COG4447@2|Bacteria,2GN53@201174|Actinobacteria	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
k59_1261357_1	1035308.AQYY01000001_gene1812	1.94e-28	113.0	COG4325@1|root,COG4325@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
k59_1782569_1	1267005.KB911257_gene920	1.27e-74	238.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,2TSCV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Major facilitator superfamily	MA20_25070	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
k59_1135226_2	573370.DMR_02350	6.17e-66	206.0	COG1335@1|root,COG1335@2|Bacteria,1RDHA@1224|Proteobacteria,42S3C@68525|delta/epsilon subdivisions,2WNV0@28221|Deltaproteobacteria,2MBI2@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	PFAM isochorismatase hydrolase	yddQ	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k59_1087162_1	471853.Bcav_2412	1.1e-68	224.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria	201174|Actinobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2155c	AlaDh_PNT_C,Mur_ligase_C,Mur_ligase_M
k59_1087162_2	1123065.ATWL01000002_gene1759	3.85e-29	117.0	COG0772@1|root,COG0772@2|Bacteria,2GKXP@201174|Actinobacteria	201174|Actinobacteria	D	Belongs to the SEDS family	ftsW	GO:0008150,GO:0040007	2.4.1.227	ko:K02563,ko:K03588	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011,ko02000,ko03036	2.A.103.1	GT28	-	FTSW_RODA_SPOVE
k59_1432132_1	768671.ThimaDRAFT_3828	3.61e-128	405.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1WX9H@135613|Chromatiales	135613|Chromatiales	C	pyruvate flavodoxin ferredoxin oxidoreductase	-	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_797846_12	1187851.A33M_2976	2.65e-24	102.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_7,Resolvase
k59_1567401_1	1174684.EBMC1_11965	5.08e-31	125.0	COG0697@1|root,COG0697@2|Bacteria,1MWSU@1224|Proteobacteria,2TSWT@28211|Alphaproteobacteria,2K1FN@204457|Sphingomonadales	204457|Sphingomonadales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_1567401_2	575586.HMPREF0016_02492	4.54e-24	99.8	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,1T1GA@1236|Gammaproteobacteria,3NK4W@468|Moraxellaceae	1236|Gammaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	iJN746.PP_2528	Cys_Met_Meta_PP
k59_1567403_1	666685.R2APBS1_3924	5.11e-24	97.1	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,1X4ZH@135614|Xanthomonadales	135614|Xanthomonadales	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
k59_1216548_1	395493.BegalDRAFT_2934	4.8e-72	241.0	COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Acyl-CoA synthetase (NDP forming)	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_159932_1	1120983.KB894570_gene1387	1.8e-05	46.6	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2TQS7@28211|Alphaproteobacteria,1JNGT@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	gor	GO:0000166,GO:0000302,GO:0000305,GO:0003674,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0017076,GO:0019725,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0065008,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901700	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_159932_2	1245471.PCA10_36070	6e-33	125.0	COG1752@1|root,COG1752@2|Bacteria,1MU6Z@1224|Proteobacteria,1RPW6@1236|Gammaproteobacteria,1YE7T@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_1567409_1	991905.SL003B_3119	8.31e-40	146.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2U2RW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_218158_1	394221.Mmar10_1474	3.7e-44	157.0	COG0845@1|root,COG0845@2|Bacteria,1MV1T@1224|Proteobacteria,2VFH0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_570061_1	471853.Bcav_0799	1.92e-62	206.0	COG1651@1|root,COG1651@2|Bacteria,2GKH8@201174|Actinobacteria	201174|Actinobacteria	O	DSBA oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
k59_1035902_1	1217720.ALOX01000224_gene344	1.14e-21	91.7	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2TRDA@28211|Alphaproteobacteria,2JP8I@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
k59_863828_1	575588.ACPN01000030_gene653	2.75e-80	267.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,3NJFY@468|Moraxellaceae	1236|Gammaproteobacteria	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)	mrcB	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008289,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031406,GO:0031975,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042277,GO:0042546,GO:0042597,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071723,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iECIAI39_1322.ECIAI39_0153,iSBO_1134.SBO_0138,iSbBS512_1146.SbBS512_E0140,iYL1228.KPN_00164	PBP1_TM,Transgly,Transpeptidase,UB2H
k59_1517796_1	1206731.BAGB01000064_gene7362	6.34e-32	122.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria,4FYN3@85025|Nocardiaceae	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_336245_2	765912.Thimo_2268	5.64e-32	129.0	COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria,1WX8D@135613|Chromatiales	135613|Chromatiales	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_797871_1	768671.ThimaDRAFT_0916	2.21e-134	402.0	COG4263@1|root,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,1RQSW@1236|Gammaproteobacteria,1WZYX@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c oxidase subunit	nosZ	-	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	COX2,Cupredoxin_1
k59_1517825_1	717785.HYPMC_2956	6.77e-75	234.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TSX9@28211|Alphaproteobacteria,3N6CA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	BQ	histone deacetylase	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
k59_1799612_1	522306.CAP2UW1_1455	2.11e-88	276.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VJJ7@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1567452_1	861299.J421_4178	7.72e-24	99.4	COG0006@1|root,COG0006@2|Bacteria,1ZSPF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
k59_1567452_2	717774.Marme_3733	1.57e-09	63.9	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1XHF9@135619|Oceanospirillales	135619|Oceanospirillales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_797876_1	1500894.JQNN01000001_gene4213	0.000506	48.1	2CJVH@1|root,2Z82D@2|Bacteria,1MX2M@1224|Proteobacteria	1224|Proteobacteria	-	-	MA20_19455	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
k59_570095_2	1713.JOFV01000002_gene592	8.4e-30	129.0	COG2385@1|root,COG5479@1|root,COG5640@1|root,COG2385@2|Bacteria,COG5479@2|Bacteria,COG5640@2|Bacteria,2GNDB@201174|Actinobacteria,4F2JD@85016|Cellulomonadaceae	201174|Actinobacteria	DM	Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme.	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,FG-GAP
k59_218201_1	1156919.QWC_05924	1.8e-33	134.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VN53@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Amp-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_1517842_1	1381123.AYOD01000049_gene13	2.46e-36	131.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,2TRXI@28211|Alphaproteobacteria,43IM9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
k59_1517842_2	224914.BMEI0623	2.44e-41	143.0	COG1309@1|root,COG1309@2|Bacteria,1RC6H@1224|Proteobacteria,2U5WX@28211|Alphaproteobacteria,1J1IF@118882|Brucellaceae	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_7,TetR_N
k59_159994_1	981369.JQMJ01000003_gene7501	2.06e-20	89.0	COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria,2NE7Q@228398|Streptacidiphilus	201174|Actinobacteria	E	Semialdehyde dehydrogenase, NAD binding domain	asd	GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3708c	Semialdhyde_dh,Semialdhyde_dhC
k59_159994_2	743718.Isova_1973	1.9e-27	107.0	COG1159@1|root,COG1159@2|Bacteria,2GJJE@201174|Actinobacteria,4F3QB@85017|Promicromonosporaceae	201174|Actinobacteria	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
k59_863878_1	1121405.dsmv_3621	9.51e-92	280.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,42P72@68525|delta/epsilon subdivisions,2WKRS@28221|Deltaproteobacteria,2MJS8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase	gyaR	-	1.1.1.26	ko:K00015,ko:K15893	ko00260,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map01100,map01110,map01120,map01130,map01200	M00532	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_1567484_1	1410674.JNKU01000004_gene1839	4.36e-31	117.0	COG0035@1|root,COG0035@2|Bacteria,1TPMT@1239|Firmicutes,4H9Y0@91061|Bacilli,3F4M0@33958|Lactobacillaceae	91061|Bacilli	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS11010	UPRTase
k59_511669_1	717774.Marme_0695	4.22e-62	209.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1XI04@135619|Oceanospirillales	135619|Oceanospirillales	L	exonuclease recJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_1451910_1	1249627.D779_2780	1.01e-87	268.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RM9E@1236|Gammaproteobacteria,1WXRI@135613|Chromatiales	135613|Chromatiales	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
k59_1451910_2	765912.Thimo_3431	6.76e-30	113.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,1RYEC@1236|Gammaproteobacteria,1WW38@135613|Chromatiales	135613|Chromatiales	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
k59_1153875_1	1077974.GOEFS_033_00080	2.05e-16	74.3	2C5MN@1|root,33A4T@2|Bacteria,2ITAQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_630387_1	1123393.KB891327_gene310	1.71e-63	205.0	COG2207@1|root,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria,2VKR0@28216|Betaproteobacteria	28216|Betaproteobacteria	K	PFAM helix-turn-helix- domain containing protein, AraC type	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
k59_1037410_1	1116472.MGMO_61c00400	6.46e-16	75.9	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,1XEIE@135618|Methylococcales	135618|Methylococcales	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_1037410_2	1163617.SCD_n01960	1.25e-17	75.9	COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,2VVV6@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	zf-CHCC
k59_1037410_3	765913.ThidrDRAFT_0070	3.08e-15	72.8	COG1943@1|root,COG1943@2|Bacteria,1P8IT@1224|Proteobacteria,1RSQC@1236|Gammaproteobacteria,1WWSI@135613|Chromatiales	135613|Chromatiales	L	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
k59_1519789_1	1120959.ATXF01000006_gene1866	3.29e-24	103.0	COG2021@1|root,COG2021@2|Bacteria,2IMKC@201174|Actinobacteria,4FQP1@85023|Microbacteriaceae	201174|Actinobacteria	E	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Hydrolase_4
k59_1627243_1	1027273.GZ77_23920	1.37e-49	175.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1XHJY@135619|Oceanospirillales	135619|Oceanospirillales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_1627243_2	523791.Kkor_0517	2.24e-05	46.2	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria,1XHV3@135619|Oceanospirillales	135619|Oceanospirillales	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
k59_630395_1	196162.Noca_3278	2.28e-91	280.0	COG0477@1|root,COG2814@2|Bacteria,2GKHG@201174|Actinobacteria,4DPT4@85009|Propionibacteriales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_748455_1	1049564.TevJSym_ac01750	3.24e-85	259.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1J5NQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	ppk2	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
k59_337761_1	1134474.O59_001818	1.22e-57	192.0	COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria,1FG4J@10|Cellvibrio	1236|Gammaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	cysB	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363	-	ko:K13634	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_1153884_1	1267005.KB911255_gene2994	1.56e-102	320.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2TRBP@28211|Alphaproteobacteria,3N6DR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_161462_1	1123065.ATWL01000007_gene3309	1.84e-85	263.0	COG0042@1|root,COG0042@2|Bacteria,2GJ8I@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	GO:0008150,GO:0010565,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0080090	-	-	-	-	-	-	-	-	-	-	Dus
k59_1111017_1	713586.KB900536_gene2913	1.41e-83	261.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1WWW0@135613|Chromatiales	135613|Chromatiales	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
k59_1111017_2	166318.Syn8016DRAFT_2329	4.58e-21	86.3	COG0229@1|root,COG0229@2|Bacteria,1G5S6@1117|Cyanobacteria,1H0VR@1129|Synechococcus	1117|Cyanobacteria	C	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
k59_1569122_1	1116472.MGMO_21c00230	3.63e-90	295.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,1RPDC@1236|Gammaproteobacteria,1XG1Q@135618|Methylococcales	135618|Methylococcales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
k59_513048_1	1304865.JAGF01000001_gene2992	1.56e-44	164.0	COG1033@1|root,COG2409@1|root,COG1033@2|Bacteria,COG2409@2|Bacteria,2GIRQ@201174|Actinobacteria,4F0TE@85016|Cellulomonadaceae	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
k59_1688332_1	367299.JOEE01000004_gene1359	3.13e-106	314.0	COG0472@1|root,COG0472@2|Bacteria,2GNEH@201174|Actinobacteria,4FEX5@85021|Intrasporangiaceae	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0008150,GO:0040007	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_1688332_2	1385521.N803_06585	2.03e-18	84.7	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4FEIE@85021|Intrasporangiaceae	201174|Actinobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2155c	AlaDh_PNT_C,Mur_ligase_C,Mur_ligase_M
k59_689636_1	187272.Mlg_0013	2.16e-126	372.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1WVZ2@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM glutamine synthetase, type I	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_1218088_1	1123229.AUBC01000034_gene1364	0.000219	48.1	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,2TST5@28211|Alphaproteobacteria,3K3W8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_337794_1	631362.Thi970DRAFT_01765	7.13e-91	281.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1WWPJ@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
k59_630426_1	349124.Hhal_0652	5.13e-75	238.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1WWIB@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_1688343_1	1095769.CAHF01000022_gene352	1.22e-07	52.8	COG2267@1|root,COG2267@2|Bacteria,1QU3E@1224|Proteobacteria,2WGMS@28216|Betaproteobacteria,4791Z@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Serine aminopeptidase, S33	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
k59_1519829_1	867903.ThesuDRAFT_01856	7.08e-76	239.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_161492_1	525897.Dbac_1840	8.71e-54	184.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,42TI5@68525|delta/epsilon subdivisions,2WQR8@28221|Deltaproteobacteria,2MG9C@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_161492_2	525897.Dbac_1841	6.6e-77	241.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42NVJ@68525|delta/epsilon subdivisions,2WJN1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
k59_1746052_1	1249627.D779_3890	1.23e-39	137.0	COG4319@1|root,COG4319@2|Bacteria,1NEUY@1224|Proteobacteria,1S6AP@1236|Gammaproteobacteria,1WYK1@135613|Chromatiales	135613|Chromatiales	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
k59_1627295_1	1250232.JQNJ01000001_gene396	1.74e-74	240.0	COG1132@1|root,COG1132@2|Bacteria,4NEAG@976|Bacteroidetes,1HY1E@117743|Flavobacteriia	976|Bacteroidetes	V	ABC transporter	-	-	-	ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
k59_337812_1	768671.ThimaDRAFT_0077	3.13e-69	224.0	COG0526@1|root,COG0526@2|Bacteria,1MWDE@1224|Proteobacteria,1S0NV@1236|Gammaproteobacteria,1WXDD@135613|Chromatiales	135613|Chromatiales	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
k59_1393213_1	497964.CfE428DRAFT_0788	8.82e-109	327.0	COG0362@1|root,COG0362@2|Bacteria,46SDE@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
k59_161506_1	572477.Alvin_1244	1.02e-36	138.0	COG0639@1|root,COG0639@2|Bacteria,1R5DR@1224|Proteobacteria,1RS9W@1236|Gammaproteobacteria,1WXS1@135613|Chromatiales	135613|Chromatiales	T	Protein phosphatase 2A homologues, catalytic domain.	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_689659_1	1380347.JNII01000007_gene308	3.9e-103	320.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria,4ERPW@85013|Frankiales	201174|Actinobacteria	KOT	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
k59_865551_1	446469.Sked_31590	1.28e-45	160.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria	201174|Actinobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016020,GO:0016465,GO:0022610,GO:0030112,GO:0030312,GO:0030313,GO:0031975,GO:0032991,GO:0036293,GO:0040007,GO:0042026,GO:0042603,GO:0043388,GO:0044093,GO:0044183,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051082,GO:0051098,GO:0051099,GO:0051101,GO:0051704,GO:0061077,GO:0065007,GO:0065009,GO:0070482,GO:0071944,GO:0101031,GO:1990220,GO:2000677,GO:2000679	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_865551_2	479431.Namu_0268	1.13e-08	52.4	COG0831@1|root,COG0831@2|Bacteria,2IKNA@201174|Actinobacteria,4ET3S@85013|Frankiales	201174|Actinobacteria	E	Belongs to the urease gamma subunit family	ureA	-	3.5.1.5	ko:K01430,ko:K14048	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Urease_beta,Urease_gamma
k59_865552_2	935567.JAES01000007_gene1868	4.14e-09	55.1	COG2259@1|root,COG2259@2|Bacteria,1MZVP@1224|Proteobacteria,1S8UI@1236|Gammaproteobacteria,1X7J3@135614|Xanthomonadales	135614|Xanthomonadales	S	PFAM DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
k59_689670_1	666685.R2APBS1_0332	7.8e-75	249.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1X4KE@135614|Xanthomonadales	135614|Xanthomonadales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1800922_1	566466.NOR53_2606	1.16e-53	177.0	COG4313@1|root,COG4313@2|Bacteria,1MWCX@1224|Proteobacteria,1S4A1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG4313 Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
k59_748525_1	198094.BA_0054	1.07e-05	53.9	COG2244@1|root,COG2244@2|Bacteria,1TNYX@1239|Firmicutes,4HACG@91061|Bacilli,1ZBBF@1386|Bacillus	91061|Bacilli	S	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid	yabM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03328	-	-	-	-	ko00000	2.A.66.2	-	-	Polysacc_synt,Polysacc_synt_C
k59_1746090_1	1120953.AUBH01000005_gene2303	2.09e-91	273.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	lolD_1	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1111095_1	471853.Bcav_3822	2.25e-35	135.0	2CFFB@1|root,32S1S@2|Bacteria,2IA1Q@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1153958_2	1485545.JQLW01000007_gene578	8.98e-11	63.9	COG2020@1|root,COG2020@2|Bacteria,1RJNV@1224|Proteobacteria	1224|Proteobacteria	O	Methyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_1218157_1	1089552.KI911559_gene1284	2.58e-59	201.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2TRXN@28211|Alphaproteobacteria,2JQ5U@204441|Rhodospirillales	204441|Rhodospirillales	M	Cell division protein FtsI penicillin-binding protein 2	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_1519901_1	519989.ECTPHS_12383	2.69e-57	186.0	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria,1WXHT@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
k59_1519901_2	1122211.JMLW01000001_gene2369	6.86e-54	174.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,1XJPI@135619|Oceanospirillales	135619|Oceanospirillales	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
k59_1393262_2	1255043.TVNIR_2982	4.24e-34	122.0	COG2193@1|root,COG2193@2|Bacteria,1PE4V@1224|Proteobacteria,1SAG5@1236|Gammaproteobacteria,1WZ24@135613|Chromatiales	135613|Chromatiales	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
k59_1569221_2	314278.NB231_17268	1.57e-32	125.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1WX0A@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_1111117_1	1269813.ATUL01000003_gene2392	4.66e-24	98.2	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,1RMHS@1236|Gammaproteobacteria,1WY1C@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
k59_1111117_2	236097.ADG881_2919	2.05e-38	138.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,1RNZZ@1236|Gammaproteobacteria,1XIE0@135619|Oceanospirillales	135619|Oceanospirillales	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_799003_1	1163409.UUA_06559	9.22e-50	179.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1X4J8@135614|Xanthomonadales	135614|Xanthomonadales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1627368_1	888056.HMPREF9062_1552	8.61e-14	71.6	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4D323@85005|Actinomycetales	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_1581657_1	1713.JOFV01000002_gene705	9.06e-100	300.0	COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria,4F2FU@85016|Cellulomonadaceae	201174|Actinobacteria	GM	ATPases associated with a variety of cellular activities	-	-	3.6.3.40	ko:K01990,ko:K09693	ko02010,map02010	M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.104	-	-	ABC_tran,Wzt_C
k59_1810751_2	644801.Psest_2017	4.38e-34	123.0	COG2153@1|root,COG2153@2|Bacteria,1MZ86@1224|Proteobacteria,1S8SK@1236|Gammaproteobacteria,1Z2ST@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	yjcF	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
k59_348512_1	283699.D172_0710	7.31e-46	159.0	2910Q@1|root,2ZNNC@2|Bacteria,1PCP3@1224|Proteobacteria,1S0BX@1236|Gammaproteobacteria,2Q4FE@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_700322_1	1082933.MEA186_30901	2.79e-115	376.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin-like,Calx-beta,DUF4347,He_PIG
k59_520882_1	1189620.AJXL01000042_gene598	4.76e-18	89.7	COG0642@1|root,COG4251@1|root,COG2205@2|Bacteria,COG4251@2|Bacteria,4NDXU@976|Bacteroidetes,1HY32@117743|Flavobacteriia,2NSQ1@237|Flavobacterium	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_9,Response_reg
k59_1581677_1	349521.HCH_00022	5.85e-135	387.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,1XHG1@135619|Oceanospirillales	135619|Oceanospirillales	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
k59_1638969_1	880072.Desac_1539	1.54e-70	229.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42M5C@68525|delta/epsilon subdivisions,2WJ54@28221|Deltaproteobacteria,2MQFP@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Lysin motif	mltD2	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
k59_464314_1	768671.ThimaDRAFT_2628	1.83e-104	308.0	COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,1RSGA@1236|Gammaproteobacteria,1WW8S@135613|Chromatiales	135613|Chromatiales	S	PFAM conserved	-	-	-	ko:K02069	-	M00211	-	-	ko00000,ko00002,ko02000	9.B.25.1	-	-	UPF0014
k59_1755929_2	1122247.C731_3595	0.000235	42.7	COG2220@1|root,COG2220@2|Bacteria,2GNXJ@201174|Actinobacteria,232B8@1762|Mycobacteriaceae	201174|Actinobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_348530_1	909663.KI867149_gene3356	2.28e-47	155.0	COG3824@1|root,COG3824@2|Bacteria,1R1JS@1224|Proteobacteria,43EIB@68525|delta/epsilon subdivisions,2X8GN@28221|Deltaproteobacteria,2MSGA@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
k59_1052277_1	318167.Sfri_1119	3.03e-37	141.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,2Q8XB@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
k59_760422_1	258594.RPA2833	8.94e-20	87.0	COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2TTFE@28211|Alphaproteobacteria,3JRQI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF815)	MA20_41470	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
k59_760422_2	717785.HYPMC_2679	3.04e-49	170.0	COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,2TUNI@28211|Alphaproteobacteria,3N6XP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	DM	Lysin motif	nlpD	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	LysM,Peptidase_M23
k59_1638974_2	448385.sce5926	7.77e-06	48.9	COG3930@1|root,COG3930@2|Bacteria,1PYFH@1224|Proteobacteria,42ZAK@68525|delta/epsilon subdivisions,2WUH8@28221|Deltaproteobacteria,2YUXI@29|Myxococcales	28221|Deltaproteobacteria	S	DUF1704	-	-	-	-	-	-	-	-	-	-	-	-	DUF1704,FGase
k59_1405088_1	765912.Thimo_1809	1.97e-113	332.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1WXNB@135613|Chromatiales	135613|Chromatiales	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_1164442_1	321327.CYA_2836	4.11e-06	53.9	COG0642@1|root,COG2203@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria,1GYFK@1129|Synechococcus	1117|Cyanobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_464356_1	1121933.AUHH01000018_gene2833	6.14e-91	282.0	COG0008@1|root,COG0008@2|Bacteria,2H1TZ@201174|Actinobacteria	201174|Actinobacteria	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
k59_808042_1	768671.ThimaDRAFT_3878	1.36e-160	465.0	COG3039@1|root,COG3039@2|Bacteria,1R6NB@1224|Proteobacteria,1S3KJ@1236|Gammaproteobacteria,1WZWM@135613|Chromatiales	135613|Chromatiales	L	Transposase	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1
k59_231278_1	1346791.M529_15195	1.09e-37	147.0	COG0745@1|root,COG3437@1|root,COG4251@1|root,COG5278@1|root,COG0745@2|Bacteria,COG3437@2|Bacteria,COG4251@2|Bacteria,COG5278@2|Bacteria,1NSQ1@1224|Proteobacteria,2TWWT@28211|Alphaproteobacteria,2KEEI@204457|Sphingomonadales	204457|Sphingomonadales	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Response_reg
k59_1810811_1	1042326.AZNV01000016_gene1639	5.74e-121	369.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,4B9AV@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1164463_1	243233.MCA1842	3.57e-100	312.0	COG2304@1|root,COG2304@2|Bacteria,1MXU0@1224|Proteobacteria,1RZHF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	serine threonine protein kinase	ppkA	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	VWA,VWA_2
k59_1230295_1	745411.B3C1_11032	2.18e-15	78.2	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1J5P6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
k59_878809_1	1123368.AUIS01000020_gene1087	1.56e-60	195.0	COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,1S3VU@1236|Gammaproteobacteria,2NBPX@225057|Acidithiobacillales	225057|Acidithiobacillales	S	HAD-hyrolase-like	-	-	3.1.3.105	ko:K22292	ko00520,map00520	-	R11785	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_1052371_1	1298593.TOL_3678	2.42e-110	330.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1XH3Y@135619|Oceanospirillales	135619|Oceanospirillales	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_1581737_1	715451.ambt_20475	1.62e-30	116.0	COG3495@1|root,COG3495@2|Bacteria,1RB8H@1224|Proteobacteria,1S4CK@1236|Gammaproteobacteria,46CS8@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3299)	-	-	-	ko:K09950	-	-	-	-	ko00000	-	-	-	DUF3299
k59_1810830_1	350058.Mvan_3265	1.53e-49	164.0	COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria,234SX@1762|Mycobacteriaceae	201174|Actinobacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_520946_1	864051.BurJ1DRAFT_4286	1.16e-39	134.0	COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,2VRJF@28216|Betaproteobacteria,1KKTZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the Smg family	smg	-	-	ko:K03747	-	-	-	-	ko00000	-	-	-	DUF494
k59_520946_2	864051.BurJ1DRAFT_0190	1.15e-18	86.7	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2VINT@28216|Betaproteobacteria,1KJN8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_808068_1	1249627.D779_3023	7.85e-32	122.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales	135613|Chromatiales	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
k59_808068_2	765913.ThidrDRAFT_3039	4.56e-39	135.0	COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,1S302@1236|Gammaproteobacteria,1WX78@135613|Chromatiales	135613|Chromatiales	C	Protein of unknown function (DUF3501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
k59_1052389_1	469610.HMPREF0189_00997	2.72e-118	357.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,1KJ0V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_464422_1	323848.Nmul_A2180	5.09e-86	264.0	COG5519@1|root,COG5519@2|Bacteria,1MW5H@1224|Proteobacteria,2VHZ7@28216|Betaproteobacteria,3732W@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Domain of unknown function (DUF927)	-	-	-	ko:K06919	-	-	-	-	ko00000	-	-	-	DUF927,PriCT_2,Toprim_3
k59_1052396_1	1385515.N791_03085	3.65e-21	92.8	COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,1RQ0T@1236|Gammaproteobacteria,1X3BT@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the Glu Leu Phe Val dehydrogenases family	leu	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_1052396_2	1279038.KB907339_gene1170	5.42e-44	153.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,2JPCY@204441|Rhodospirillales	204441|Rhodospirillales	I	COG1960 Acyl-CoA dehydrogenases	-	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1405133_1	1049564.TevJSym_ay00240	3.13e-97	298.0	COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,1RPDV@1236|Gammaproteobacteria,1J5GA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_464426_1	1249627.D779_1325	6.71e-21	93.2	COG0772@1|root,COG0772@2|Bacteria,1R537@1224|Proteobacteria,1RR9J@1236|Gammaproteobacteria,1WWS3@135613|Chromatiales	135613|Chromatiales	D	Belongs to the SEDS family	-	-	-	-	-	-	-	-	-	-	-	-	FTSW_RODA_SPOVE
k59_1756014_1	1120941.AUBL01000001_gene1419	1.62e-55	185.0	COG0107@1|root,COG0107@2|Bacteria,2GIRP@201174|Actinobacteria,4D3BI@85005|Actinomycetales	201174|Actinobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0008150,GO:0016740,GO:0016757,GO:0016763,GO:0040007	4.1.3.27	ko:K01657,ko:K02500	ko00340,ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00340,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023,M00026	R00985,R00986,R04558	RC00010,RC01190,RC01943,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_760527_2	1123052.AUDF01000002_gene501	3.11e-43	150.0	COG1349@1|root,COG1349@2|Bacteria,2H5X4@201174|Actinobacteria,4FMRK@85023|Microbacteriaceae	201174|Actinobacteria	K	DeoR C terminal sensor domain	-	-	-	ko:K02081,ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
k59_1581757_1	765913.ThidrDRAFT_2344	2.37e-21	91.3	COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,1RZQ2@1236|Gammaproteobacteria,1WXSM@135613|Chromatiales	135613|Chromatiales	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
k59_1581757_2	765911.Thivi_1025	1.11e-26	103.0	COG1977@1|root,COG3536@1|root,COG1977@2|Bacteria,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,1TKAA@1236|Gammaproteobacteria,1X136@135613|Chromatiales	135613|Chromatiales	H	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971,ThiS
k59_1405143_1	1869.MB27_01275	1.29e-12	73.2	COG0515@1|root,COG2199@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,GAF_2,GGDEF,GerE,HTH_30,MASE1,Pkinase
k59_1230342_1	519989.ECTPHS_02601	1.26e-53	181.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1WX7X@135613|Chromatiales	135613|Chromatiales	J	SAM-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
k59_1464309_1	754476.Q7A_1267	2.82e-97	288.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,4604Q@72273|Thiotrichales	72273|Thiotrichales	D	TIGRFAM Cell division ATP-binding protein FtsE	-	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_1164566_1	1249627.D779_0248	6.38e-95	295.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1WXXQ@135613|Chromatiales	135613|Chromatiales	G	Alpha amylase catalytic	-	-	2.4.1.7	ko:K00690	ko00500,map00500	-	R00803	RC00028	ko00000,ko00001,ko01000	-	GH13	-	-
k59_1810889_1	1120950.KB892760_gene5731	9.76e-79	243.0	COG0861@1|root,COG0861@2|Bacteria,2GRV3@201174|Actinobacteria	201174|Actinobacteria	P	Membrane protein TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
k59_1405171_2	521098.Aaci_0824	3.56e-08	57.4	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,4HA1H@91061|Bacilli,277ZZ@186823|Alicyclobacillaceae	91061|Bacilli	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_521007_2	857087.Metme_4192	5.4e-81	243.0	COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,1S21E@1236|Gammaproteobacteria,1XEKU@135618|Methylococcales	135618|Methylococcales	H	May be involved in the biosynthesis of molybdopterin	moaB	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
k59_878892_1	1237500.ANBA01000015_gene2293	5.98e-21	92.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,2GK62@201174|Actinobacteria,4EGFP@85012|Streptosporangiales	201174|Actinobacteria	KOT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Response_reg
k59_878892_2	1380356.JNIK01000017_gene2791	2.51e-51	181.0	COG4191@1|root,COG4191@2|Bacteria,2GMRD@201174|Actinobacteria,4ETTS@85013|Frankiales	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,cNMP_binding
k59_231393_1	768670.Calni_0912	2.02e-07	57.0	COG2020@1|root,COG2020@2|Bacteria,2GFMN@200930|Deferribacteres	200930|Deferribacteres	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_641780_1	1165096.ARWF01000001_gene2241	2.39e-95	288.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,2KKV0@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	PFAM type II secretion system protein E	-	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_582679_2	1121918.ARWE01000001_gene3254	3.28e-106	317.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_466468_1	713586.KB900536_gene1092	3.64e-92	284.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1WW9V@135613|Chromatiales	135613|Chromatiales	J	TIGRFAM ribonuclease, Rne Rng family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_1583125_1	472759.Nhal_2448	8.76e-44	154.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1WW48@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_1232065_1	933262.AXAM01000013_gene1310	4.27e-116	360.0	COG1026@1|root,COG1026@2|Bacteria,1MVDJ@1224|Proteobacteria,42MRG@68525|delta/epsilon subdivisions,2WJ5Q@28221|Deltaproteobacteria,2MINB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Peptidase M16C associated	PREP	-	-	ko:K06972	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M16C_assoc,Peptidase_M16,Peptidase_M16_C
k59_641795_2	68570.DC74_6369	3.54e-18	82.0	COG1670@1|root,COG1670@2|Bacteria,2IKXU@201174|Actinobacteria	201174|Actinobacteria	J	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_702117_1	1284679.HMPREF1626_00695	2.45e-08	55.1	COG1321@1|root,COG1321@2|Bacteria,2GK7P@201174|Actinobacteria,4D4Y5@85005|Actinomycetales	201174|Actinobacteria	K	Iron dependent repressor DNA binding domain protein	sirR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
k59_702117_2	1123065.ATWL01000007_gene3240	5.57e-141	427.0	COG1408@1|root,COG1408@2|Bacteria,2GM8M@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
k59_1465681_1	1191523.MROS_0031	1.15e-31	124.0	COG4146@1|root,COG4146@2|Bacteria	2|Bacteria	S	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
k59_1465681_2	392500.Swoo_2202	1.77e-48	168.0	COG2211@1|root,COG2211@2|Bacteria,1MX4Z@1224|Proteobacteria,1RRNW@1236|Gammaproteobacteria,2Q96J@267890|Shewanellaceae	1236|Gammaproteobacteria	G	PFAM major facilitator superfamily MFS_1	malT	-	-	ko:K16211	-	-	-	-	ko00000,ko02000	2.A.2.6	-	-	MFS_1
k59_1232074_1	1384056.N787_06560	4.71e-109	329.0	COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,1RRQE@1236|Gammaproteobacteria,1X7AT@135614|Xanthomonadales	135614|Xanthomonadales	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh_C
k59_1232074_2	1442599.JAAN01000026_gene1161	2.85e-08	55.8	2BWJV@1|root,32U7J@2|Bacteria,1N47S@1224|Proteobacteria,1S8XJ@1236|Gammaproteobacteria,1X7VT@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1054821_1	570967.JMLV01000001_gene2424	1.31e-22	95.9	COG3332@1|root,COG3332@2|Bacteria,1RDBS@1224|Proteobacteria,2TSN7@28211|Alphaproteobacteria,2JPCS@204441|Rhodospirillales	204441|Rhodospirillales	S	Transport and Golgi organisation 2	-	-	-	-	-	-	-	-	-	-	-	-	TANGO2
k59_1054821_2	1134474.O59_002205	1.59e-23	90.5	2E4UA@1|root,32ZNM@2|Bacteria,1NAZR@1224|Proteobacteria,1SC82@1236|Gammaproteobacteria,1FHQY@10|Cellvibrio	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1054821_3	497964.CfE428DRAFT_1671	2.27e-17	79.3	COG1573@1|root,COG1573@2|Bacteria,46V7R@74201|Verrucomicrobia	74201|Verrucomicrobia	L	PFAM Uracil-DNA glycosylase superfamily	-	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_175312_1	582899.Hden_1800	2.71e-121	372.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria,3N661@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_582706_1	488538.SAR116_0958	1.45e-103	306.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2TQR9@28211|Alphaproteobacteria,4BQZ5@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Amino-transferase class IV	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_522707_1	1131553.JIBI01000021_gene276	1.7e-80	249.0	COG1253@1|root,COG1253@2|Bacteria,1N0IQ@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function DUF21	-	-	-	-	-	-	-	-	-	-	-	-	DUF21
k59_1166746_1	309803.CTN_1608	6.79e-22	94.0	COG1670@1|root,COG1670@2|Bacteria,2GCW5@200918|Thermotogae	200918|Thermotogae	J	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_1757600_1	1049564.TevJSym_bf00120	2.31e-142	410.0	COG1897@1|root,COG1897@2|Bacteria,1MV64@1224|Proteobacteria,1RM7T@1236|Gammaproteobacteria,1J6TN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	metAS	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0008899,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.46	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	M00017	R01777	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	iECUMN_1333.ECUMN_4539,iSBO_1134.SBO_4033,iSbBS512_1146.SbBS512_E4507	HTS
k59_1406482_1	498761.HM1_1642	6.97e-77	243.0	COG0436@1|root,COG0436@2|Bacteria,1TP36@1239|Firmicutes,248ZV@186801|Clostridia	186801|Clostridia	E	Aminotransferase	yhdR	-	2.6.1.1	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1054877_1	1121405.dsmv_2651	3.15e-59	200.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales	68525|delta/epsilon subdivisions	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1812683_1	1304872.JAGC01000009_gene1007	9.39e-39	148.0	COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,42MA5@68525|delta/epsilon subdivisions,2WJGZ@28221|Deltaproteobacteria,2M9Y5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
k59_582738_2	686340.Metal_2982	2.27e-26	111.0	COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria,1XEHQ@135618|Methylococcales	135618|Methylococcales	H	HemY protein N-terminus	-	-	-	ko:K02498	-	-	-	-	ko00000	-	-	-	HemY_N,TPR_8
k59_1232139_1	1123511.KB905844_gene1163	2.52e-40	143.0	COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,4H2PG@909932|Negativicutes	909932|Negativicutes	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_466580_1	257313.BP2437	9.07e-28	105.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VHR2@28216|Betaproteobacteria,3T26D@506|Alcaligenaceae	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_466580_2	396588.Tgr7_1084	3.13e-12	69.7	COG3073@1|root,COG3073@2|Bacteria,1N9FN@1224|Proteobacteria,1SGPC@1236|Gammaproteobacteria,1WYNC@135613|Chromatiales	135613|Chromatiales	T	PFAM Anti sigma-E protein RseA	-	-	-	ko:K03597	-	-	-	-	ko00000,ko03021	-	-	-	RseA_N
k59_466580_3	1177181.T9A_01858	4.07e-21	97.8	COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,1RNF3@1236|Gammaproteobacteria,1XKB8@135619|Oceanospirillales	135619|Oceanospirillales	T	Negative regulator of sigma E activity	mucB	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	MucB_RseB,MucB_RseB_C
k59_414403_1	1454004.AW11_03086	4.55e-106	330.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2VIFW@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Pfam Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_238914_2	509635.N824_16215	4.93e-07	54.7	COG2085@1|root,COG2085@2|Bacteria,4NEC7@976|Bacteroidetes,1IUJA@117747|Sphingobacteriia	976|Bacteroidetes	S	Shikimate / quinate 5-dehydrogenase	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
k59_238916_1	765913.ThidrDRAFT_1984	1.25e-22	92.0	COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,1RSM2@1236|Gammaproteobacteria,1WX5K@135613|Chromatiales	135613|Chromatiales	L	Belongs to the Nudix hydrolase family	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_238916_2	388399.SSE37_23569	2.58e-18	80.9	2AGHX@1|root,316QI@2|Bacteria,1RI7I@1224|Proteobacteria,2U9H2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1060741_1	768671.ThimaDRAFT_0602	2.87e-111	353.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW08@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_414405_1	768671.ThimaDRAFT_4705	1.56e-120	360.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria,1WWCP@135613|Chromatiales	135613|Chromatiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
k59_64400_1	1242864.D187_002372	5.31e-83	261.0	COG4143@1|root,COG4143@2|Bacteria,1R4IE@1224|Proteobacteria,42QHK@68525|delta/epsilon subdivisions,2WUK2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	(ABC) transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_473316_1	187272.Mlg_2622	2.47e-166	478.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales	135613|Chromatiales	P	PFAM TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_357918_1	1172185.KB911524_gene3299	4.86e-14	70.9	COG1192@1|root,COG1192@2|Bacteria,2GNEQ@201174|Actinobacteria,4FWJC@85025|Nocardiaceae	201174|Actinobacteria	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_766412_1	1449065.JMLL01000018_gene1815	3.74e-47	169.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2TS6C@28211|Alphaproteobacteria,43HNJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1764560_1	469383.Cwoe_5389	2.3e-35	137.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria	201174|Actinobacteria	M	Exporter of polyketide	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
k59_532115_1	1122212.AULO01000015_gene2117	2.83e-22	99.0	2DA4I@1|root,32TUN@2|Bacteria,1N0WK@1224|Proteobacteria,1S6HI@1236|Gammaproteobacteria,1XK37@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1588387_1	1713.JOFV01000008_gene3234	1.02e-78	253.0	COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4F0HR@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM CBS domain containing protein	corC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_825284_1	1194165.CAJF01000005_gene2291	1.68e-105	322.0	COG0265@1|root,COG0265@2|Bacteria,2IB8S@201174|Actinobacteria	201174|Actinobacteria	O	Trypsin-like peptidase domain	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_473325_1	351016.RAZWK3B_19196	4.86e-147	424.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TTAW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1764569_1	1168059.KB899087_gene4470	3.3e-48	162.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2TU72@28211|Alphaproteobacteria,3F0X8@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	HTH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k59_1764569_2	999547.KI421500_gene3542	7.53e-33	115.0	COG2963@1|root,COG2963@2|Bacteria,1N1AA@1224|Proteobacteria,2UC5K@28211|Alphaproteobacteria,282EI@191028|Leisingera	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k59_886266_1	1121887.AUDK01000018_gene3290	1.84e-50	172.0	COG2017@1|root,COG2017@2|Bacteria,4NF5G@976|Bacteroidetes,1HZCR@117743|Flavobacteriia,2NV14@237|Flavobacterium	976|Bacteroidetes	G	Converts alpha-aldose to the beta-anomer	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
k59_886266_2	1168034.FH5T_00645	5.93e-09	56.2	COG2160@1|root,COG2160@2|Bacteria,4NHGG@976|Bacteroidetes,2FMIU@200643|Bacteroidia	976|Bacteroidetes	G	Catalyzes the conversion of L-arabinose to L-ribulose	araA	-	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	-	Arabinose_Iso_C,Arabinose_Isome
k59_1297328_1	367299.JOEE01000010_gene3330	6.12e-54	180.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,4FEG7@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0016740,GO:0016765,GO:0016829,GO:0016846	-	ko:K10764	ko00270,ko00920,ko01100,map00270,map00920,map01100	-	R01288	RC00020,RC02848	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0391	Cys_Met_Meta_PP
k59_1297328_2	367299.JOEE01000010_gene3329	3.49e-43	144.0	COG3832@1|root,COG3832@2|Bacteria,2IFJT@201174|Actinobacteria,4FGZW@85021|Intrasporangiaceae	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
k59_825287_1	1121441.AUCX01000021_gene706	3.46e-119	352.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,42MXS@68525|delta/epsilon subdivisions,2WKEK@28221|Deltaproteobacteria,2M8WD@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Seven times multi-haem cytochrome CxxCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Multi-haem_cyto
k59_649489_1	1095769.CAHF01000022_gene318	9.13e-129	391.0	COG0515@1|root,COG0515@2|Bacteria,1QVRP@1224|Proteobacteria,2WI9Z@28216|Betaproteobacteria,47963@75682|Oxalobacteraceae	28216|Betaproteobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_767078_2	1122165.AUHS01000014_gene2770	3.8e-19	82.8	COG3247@1|root,COG3247@2|Bacteria,1RFIH@1224|Proteobacteria,1S6XJ@1236|Gammaproteobacteria,1JEA1@118969|Legionellales	118969|Legionellales	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
k59_1472309_1	68570.DC74_369	1.13e-05	55.1	COG0380@1|root,COG0561@1|root,COG0380@2|Bacteria,COG0561@2|Bacteria,2GMX7@201174|Actinobacteria	201174|Actinobacteria	G	synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_20,S6PP
k59_650332_1	1437824.BN940_08856	2.52e-65	209.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VH7N@28216|Betaproteobacteria,3T1FX@506|Alcaligenaceae	28216|Betaproteobacteria	L	exodeoxyribonuclease III	xthA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_650332_2	1123256.KB907929_gene3268	4.42e-44	154.0	2CIBN@1|root,2Z8JT@2|Bacteria,1R902@1224|Proteobacteria,1RXPM@1236|Gammaproteobacteria,1X5H4@135614|Xanthomonadales	135614|Xanthomonadales	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_359153_1	1193181.BN10_130028	2.66e-07	51.6	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4FEBA@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_359153_2	1385520.N802_07625	1.13e-102	306.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,4FEDF@85021|Intrasporangiaceae	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	appD	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1413560_1	1121405.dsmv_2611	6.55e-61	209.0	COG0603@1|root,COG1402@1|root,COG0603@2|Bacteria,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2X9RQ@28221|Deltaproteobacteria,2MPA0@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
k59_709010_1	1304865.JAGF01000001_gene1449	9.76e-165	487.0	COG0247@1|root,COG0247@2|Bacteria,2GJ7M@201174|Actinobacteria	201174|Actinobacteria	C	Fe-S oxidoreductase	fadF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_1826667_1	211165.AJLN01000079_gene367	1.01e-33	129.0	COG3119@1|root,COG3119@2|Bacteria,1G3QV@1117|Cyanobacteria,1JJZ1@1189|Stigonemataceae	1117|Cyanobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_1826667_2	565045.NOR51B_608	1.06e-06	51.6	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1S3FP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_946350_2	398527.Bphyt_7267	8.51e-42	147.0	COG4566@1|root,COG4566@2|Bacteria,1R47Z@1224|Proteobacteria,2VQH8@28216|Betaproteobacteria,1JZZ5@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_946350_3	107636.JQNK01000009_gene2434	1.97e-16	79.7	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,36Y0R@31993|Methylocystaceae	28211|Alphaproteobacteria	T	PAS fold	fixL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,PAS,PAS_3,PAS_9
k59_1061702_1	1411685.U062_00021	6.98e-74	239.0	COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,1RN02@1236|Gammaproteobacteria,1J4WQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Aspartate tyrosine aromatic aminotransferase	phhC	-	2.6.1.1,2.6.1.57	ko:K00813,ko:K00832	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	M00024,M00025,M00034,M00040	R00355,R00694,R00734,R00896,R01731,R02433,R02619,R05052,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1061702_2	1205680.CAKO01000007_gene4220	3.47e-08	53.9	COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,2TQYU@28211|Alphaproteobacteria,2JQ2T@204441|Rhodospirillales	204441|Rhodospirillales	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
k59_826129_2	765911.Thivi_0273	2.29e-74	246.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1WWSC@135613|Chromatiales	135613|Chromatiales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_650343_1	479432.Sros_0582	5.86e-05	50.4	COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,4EGRX@85012|Streptosporangiales	201174|Actinobacteria	Q	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044464,GO:0071944	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_1706994_2	1286106.MPL1_00522	2.24e-19	87.4	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,1RMFK@1236|Gammaproteobacteria,461ZM@72273|Thiotrichales	72273|Thiotrichales	NT	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
k59_1061716_1	1411685.U062_00816	2.49e-10	61.2	29B18@1|root,2ZY02@2|Bacteria,1REMG@1224|Proteobacteria,1S4B1@1236|Gammaproteobacteria,1JA2W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_240142_1	998674.ATTE01000001_gene4279	4.64e-247	682.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,45ZSW@72273|Thiotrichales	72273|Thiotrichales	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_532982_1	1396141.BATP01000066_gene1894	4.99e-74	226.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_Tnp_IS630
k59_591752_1	870187.Thini_3018	9.09e-61	207.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,45ZXP@72273|Thiotrichales	72273|Thiotrichales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_1472350_1	686578.AFFX01000002_gene582	6.77e-71	236.0	COG0421@1|root,COG0421@2|Bacteria,1QVJA@1224|Proteobacteria,1RYYT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Spermidine synthase	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
k59_591753_1	472759.Nhal_0220	6.42e-81	244.0	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,1S3UD@1236|Gammaproteobacteria,1WY8W@135613|Chromatiales	135613|Chromatiales	E	D,D-heptose 1,7-bisphosphate phosphatase	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
k59_591753_2	1049564.TevJSym_aq00120	1.5e-27	102.0	2F88A@1|root,340MG@2|Bacteria,1NXS1@1224|Proteobacteria,1SQ1P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Phosphoribosyl-ATP pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG
k59_887513_1	1121456.ATVA01000014_gene561	1.88e-53	181.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42SS8@68525|delta/epsilon subdivisions,2WPMH@28221|Deltaproteobacteria,2MAUU@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Metallophosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
k59_1765401_1	84531.JMTZ01000067_gene1716	3.68e-114	343.0	COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1RPVU@1236|Gammaproteobacteria,1X59X@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	creC	-	2.7.13.3	ko:K07641	ko02020,map02020	M00449	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_1237543_1	1122603.ATVI01000005_gene3185	3.57e-44	157.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1X4G4@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_1237543_2	1049564.TevJSym_au00500	7.03e-34	123.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1J4QY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the KdsA family	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
k59_887514_1	743719.PaelaDRAFT_3424	9.1e-23	102.0	COG3507@1|root,COG3507@2|Bacteria,1TPHA@1239|Firmicutes,4HBSN@91061|Bacilli,26R1P@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 43 family	yxiA	-	3.2.1.99	ko:K06113	-	-	-	-	ko00000,ko01000	-	GH43	-	GH43_C,Glyco_hydro_43,Laminin_G_3
k59_1826705_1	98439.AJLL01000070_gene1417	4.18e-60	193.0	COG1051@1|root,COG1051@2|Bacteria,1G4H7@1117|Cyanobacteria,1JH32@1189|Stigonemataceae	1117|Cyanobacteria	F	Hydrolase of X-linked nucleoside diphosphate N terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N
k59_1826705_2	1089455.MOPEL_022_00040	4.14e-06	48.5	COG1438@1|root,COG1438@2|Bacteria,2GKA5@201174|Actinobacteria,4F6XH@85018|Dermatophilaceae	201174|Actinobacteria	K	Regulates arginine biosynthesis genes	argR	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
k59_887517_1	580332.Slit_1611	2.8e-97	298.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,2VJT0@28216|Betaproteobacteria,44WEG@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hoxH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
k59_1413590_1	880072.Desac_1954	3.17e-55	186.0	COG1560@1|root,COG1560@2|Bacteria	2|Bacteria	M	Kdo2-lipid A biosynthetic process	waaM	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_826156_2	1214065.BAGV01000061_gene966	2.96e-28	110.0	COG2813@1|root,COG2813@2|Bacteria,1NEMR@1224|Proteobacteria,1RMXE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA	rlmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052916,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.172,2.1.1.174	ko:K00564,ko:K11391	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	MTS
k59_767110_1	1380393.JHVP01000005_gene3731	9.71e-62	197.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
k59_767110_2	547163.BN979_01355	2.23e-10	60.5	COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,233HK@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1178666_1	1304885.AUEY01000028_gene2817	1.06e-77	243.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42MKP@68525|delta/epsilon subdivisions,2WJU9@28221|Deltaproteobacteria,2MIKJ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	transport system permease	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_946403_1	880072.Desac_0822	4.13e-64	220.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_122017_1	911045.PSE_3737	6.35e-42	171.0	COG1289@1|root,COG1289@2|Bacteria	2|Bacteria	S	transmembrane transporter activity	VPA1578	-	-	-	-	-	-	-	-	-	-	-	FUSC
k59_122017_4	765912.Thimo_0708	8.68e-175	534.0	COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1WXKG@135613|Chromatiales	135613|Chromatiales	DM	mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM,MscS_porin
k59_1707015_1	76114.ebA877	1.93e-37	135.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VJD9@28216|Betaproteobacteria,2KUGV@206389|Rhodocyclales	206389|Rhodocyclales	C	radical SAM protein	nirJ	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
k59_1707015_2	1163617.SCD_n00375	4.23e-73	224.0	COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,2VR9X@28216|Betaproteobacteria	28216|Betaproteobacteria	K	transcriptional regulator AsnC family	nirH	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
k59_240179_1	1123392.AQWL01000002_gene1767	7.35e-139	402.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VJD9@28216|Betaproteobacteria,1KSZD@119069|Hydrogenophilales	119069|Hydrogenophilales	C	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
k59_709046_1	743718.Isova_1457	5.12e-98	301.0	COG0147@1|root,COG0147@2|Bacteria,2GKJT@201174|Actinobacteria,4F3Z6@85017|Promicromonosporaceae	201174|Actinobacteria	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_1354761_1	390989.JOEG01000014_gene2987	3.64e-50	167.0	COG4122@1|root,COG4122@2|Bacteria,2GP7A@201174|Actinobacteria,4DG6V@85008|Micromonosporales	201174|Actinobacteria	S	O-methyltransferase	-	-	-	ko:K21189	ko01059,map01059	M00828	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
k59_1354761_2	930171.Asphe3_09800	7.9e-07	51.6	COG2267@1|root,COG2267@2|Bacteria,2IBMU@201174|Actinobacteria	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1354761_4	1123065.ATWL01000001_gene412	1.36e-35	122.0	COG1314@1|root,COG1314@2|Bacteria,2GR31@201174|Actinobacteria	201174|Actinobacteria	U	Preprotein translocase SecG subunit	secG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
k59_65730_1	1496688.ER33_07135	0.0	1301.0	COG3119@1|root,COG3119@2|Bacteria,1G22U@1117|Cyanobacteria,22RRC@167375|Cyanobium	1117|Cyanobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k59_65730_2	1133850.SHJG_7109	1.21e-20	94.4	COG1131@1|root,COG1131@2|Bacteria,2I1R7@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_65730_3	1304865.JAGF01000001_gene1612	6.53e-10	59.3	COG0600@1|root,COG0600@2|Bacteria,2I919@201174|Actinobacteria	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_650375_1	767817.Desgi_4276	2.01e-44	162.0	COG3437@1|root,COG4191@1|root,COG3437@2|Bacteria,COG4191@2|Bacteria,1UJKB@1239|Firmicutes,25G1F@186801|Clostridia,267E3@186807|Peptococcaceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_591766_1	338963.Pcar_0515	2.71e-82	252.0	COG2126@1|root,COG2126@2|Bacteria,1MXCS@1224|Proteobacteria,42NVQ@68525|delta/epsilon subdivisions,2WJFT@28221|Deltaproteobacteria,43TVE@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ion transport protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans
k59_6265_1	396588.Tgr7_1159	1.86e-110	323.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,1RN0Z@1236|Gammaproteobacteria,1WW47@135613|Chromatiales	135613|Chromatiales	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_946414_1	2342.SOPEG_0004	1.12e-68	217.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666	ATP-synt_A
k59_1178673_1	1382356.JQMP01000003_gene1983	2.91e-33	122.0	COG1656@1|root,COG1656@2|Bacteria,2G6GZ@200795|Chloroflexi,27Y8I@189775|Thermomicrobia	189775|Thermomicrobia	H	Mut7-C ubiquitin	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
k59_1712395_1	439235.Dalk_3310	2.23e-85	263.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,42M0T@68525|delta/epsilon subdivisions,2WJ3C@28221|Deltaproteobacteria,2MHY8@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_1070185_2	1158294.JOMI01000001_gene1535	2.06e-06	50.8	COG0266@1|root,COG0266@2|Bacteria,4NIT4@976|Bacteroidetes,2FPIR@200643|Bacteroidia	976|Bacteroidetes	L	Formamidopyrimidine-DNA glycosylase H2TH domain	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_1480790_1	760568.Desku_2186	3.46e-74	240.0	COG3039@1|root,COG3039@2|Bacteria,1TRBK@1239|Firmicutes,24DZ0@186801|Clostridia,262XU@186807|Peptococcaceae	186801|Clostridia	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_73891_1	1267005.KB911256_gene1497	3.77e-07	50.8	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TSQF@28211|Alphaproteobacteria,3N7ZT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Two component transcriptional regulator	petR	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_73891_2	1267005.KB911256_gene1498	1.06e-68	214.0	COG1846@1|root,COG1846@2|Bacteria,1RIX7@1224|Proteobacteria,2U94M@28211|Alphaproteobacteria,3N715@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	petP	-	-	-	-	-	-	-	-	-	-	-	MarR_2
k59_715199_1	545276.KB898732_gene2480	1.03e-128	375.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1WW2B@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
k59_715199_2	187272.Mlg_1304	3.72e-18	82.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,1S74N@1236|Gammaproteobacteria,1WY76@135613|Chromatiales	135613|Chromatiales	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
k59_1835008_1	237368.SCABRO_03450	2.22e-108	330.0	COG0519@1|root,COG0519@2|Bacteria,2IX19@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_954637_1	1499967.BAYZ01000171_gene5567	1.07e-12	73.2	COG1148@1|root,COG4231@1|root,COG1148@2|Bacteria,COG4231@2|Bacteria	2|Bacteria	C	indolepyruvate ferredoxin oxidoreductase activity	bamE	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Fer4,Fer4_20,Fer4_7,Pyr_redox_2
k59_1480793_1	314285.KT71_00735	2.4e-23	98.2	COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,1RMRB@1236|Gammaproteobacteria,1J5BT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
k59_1480793_2	1323663.AROI01000016_gene302	2.01e-16	80.1	COG1705@1|root,COG3951@1|root,COG1705@2|Bacteria,COG3951@2|Bacteria,1MX2W@1224|Proteobacteria,1RPGY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	Flagellar rod assembly protein muramidase FlgJ	flgJ	GO:0003674,GO:0005198	-	ko:K02395	-	-	-	-	ko00000,ko02035	-	-	-	Glucosaminidase,Rod-binding
k59_1124313_1	743720.Psefu_2086	3.53e-46	169.0	COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,1RNJ3@1236|Gammaproteobacteria,1YVVT@136845|Pseudomonas putida group	1236|Gammaproteobacteria	M	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_1712403_1	585531.HMPREF0063_11708	6.81e-89	266.0	COG0692@1|root,COG0692@2|Bacteria,2GJ9Z@201174|Actinobacteria,4DN2B@85009|Propionibacteriales	201174|Actinobacteria	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine	ung	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_954649_1	1049564.TevJSym_ao00280	1.72e-66	226.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1224|Proteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_251353_1	640081.Dsui_1930	2.46e-83	259.0	COG1522@1|root,COG1522@2|Bacteria,1NVYY@1224|Proteobacteria,2VHP8@28216|Betaproteobacteria,2KUR4@206389|Rhodocyclales	206389|Rhodocyclales	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_73910_1	696369.KI912183_gene682	1.28e-14	75.1	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia,25ZXR@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k59_1245745_2	349124.Hhal_2130	3.43e-108	322.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1WW9Z@135613|Chromatiales	135613|Chromatiales	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
k59_1245745_3	555778.Hneap_0745	6.62e-36	127.0	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,1SA62@1236|Gammaproteobacteria,1WYYD@135613|Chromatiales	135613|Chromatiales	G	system, fructose subfamily IIA component	-	-	2.7.1.194	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	M00283,M00550	R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.7.1	-	-	EIIA-man
k59_1654781_1	502025.Hoch_5691	2.93e-28	110.0	COG3011@1|root,COG3011@2|Bacteria,1PV31@1224|Proteobacteria,42WAC@68525|delta/epsilon subdivisions,2WSCZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function, DUF393	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
k59_1654781_2	1535422.ND16A_3594	2.75e-26	99.0	COG3785@1|root,COG3785@2|Bacteria,1RHM7@1224|Proteobacteria,1T11M@1236|Gammaproteobacteria,2Q8A0@267889|Colwelliaceae	1236|Gammaproteobacteria	S	Hemimethylated DNA-binding protein YccV like	-	-	-	ko:K11940	-	-	-	-	ko00000,ko03036	-	-	-	YccV-like
k59_1360312_1	485913.Krac_2014	5.27e-98	299.0	COG0076@1|root,COG0076@2|Bacteria,2G76V@200795|Chloroflexi	200795|Chloroflexi	H	COGs COG0076 Glutamate decarboxylase and related PLP-dependent protein	-	-	4.1.2.27	ko:K01634	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00100	R02464,R06516	RC00264,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
k59_954664_1	1101192.KB910516_gene348	9.23e-78	254.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2TRVS@28211|Alphaproteobacteria,1JTHV@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.196,3.2.1.68	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02111,R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_832380_1	1265313.HRUBRA_02645	1.88e-30	125.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1J4HR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the peptidase S16 family	ycbZ	-	-	ko:K04770	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C
k59_73920_1	1488328.JMCL01000104_gene3996	7.74e-14	70.9	COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,1RNTW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	purT	GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008776,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016741,GO:0016742,GO:0016772,GO:0016774,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.2.2	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	iSDY_1059.SDY_1135	ATP-grasp,Epimerase
k59_1712416_1	391589.RGAI101_4236	1.08e-41	149.0	COG1796@1|root,COG1796@2|Bacteria,1QF8Z@1224|Proteobacteria	1224|Proteobacteria	L	Helix-hairpin-helix domain	dpbF	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	HHH_5,HHH_8
k59_480014_1	504472.Slin_1577	1.48e-23	100.0	2DC6Z@1|root,2ZD43@2|Bacteria	2|Bacteria	S	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_3
k59_367443_1	448385.sce6976	1.25e-42	163.0	COG1413@1|root,COG3202@1|root,COG1413@2|Bacteria,COG3202@2|Bacteria	2|Bacteria	C	ATP:ADP antiporter activity	-	-	-	ko:K01932,ko:K03301	-	-	-	-	ko00000,ko01000	2.A.12	-	-	Glyco_transf_4,Glycos_transf_1,HEAT_2,TLC
k59_895701_1	1384056.N787_14085	9.33e-42	144.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,1X4HD@135614|Xanthomonadales	135614|Xanthomonadales	D	cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k59_895701_2	1283300.ATXB01000001_gene1084	1.98e-55	191.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,1XE6A@135618|Methylococcales	135618|Methylococcales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	COX15-CtaA,SRP54,SRP54_N
k59_538822_2	323848.Nmul_A0308	9.24e-96	294.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2VHQU@28216|Betaproteobacteria,371UU@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_1070230_1	1380354.JIAN01000006_gene674	3.23e-108	337.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4F0DB@85016|Cellulomonadaceae	201174|Actinobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_832386_1	156889.Mmc1_1089	6.65e-14	72.4	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,dCache_1,sCache_3_3
k59_832386_2	1232410.KI421413_gene776	9.97e-10	61.2	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,42PRD@68525|delta/epsilon subdivisions,2X5MX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_251390_1	713586.KB900536_gene1253	1.18e-172	500.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1WWE5@135613|Chromatiales	135613|Chromatiales	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_1480839_1	243233.MCA1476	1.42e-101	312.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,1XEKR@135618|Methylococcales	135618|Methylococcales	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_715251_1	396588.Tgr7_2124	5.46e-36	138.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1WWH2@135613|Chromatiales	135613|Chromatiales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1420017_1	713586.KB900536_gene534	2.02e-168	508.0	COG0574@1|root,COG0574@2|Bacteria,1P35R@1224|Proteobacteria,1SWBY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
k59_539460_1	314285.KT71_15114	3.81e-27	104.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,1J9A9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	CDP-alcohol phosphatidyltransferase	pgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0031224,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	iAF1260.b1912,iAPECO1_1312.APECO1_954,iB21_1397.B21_01866,iBWG_1329.BWG_1721,iE2348C_1286.E2348C_2030,iEC042_1314.EC042_2073,iEC55989_1330.EC55989_2132,iECABU_c1320.ECABU_c21710,iECBD_1354.ECBD_1731,iECB_1328.ECB_01877,iECDH10B_1368.ECDH10B_2053,iECDH1ME8569_1439.ECDH1ME8569_1852,iECD_1391.ECD_01877,iECED1_1282.ECED1_2177,iECH74115_1262.ECH74115_2684,iECIAI1_1343.ECIAI1_1996,iECIAI39_1322.ECIAI39_1143,iECNA114_1301.ECNA114_2003,iECO103_1326.ECO103_2168,iECO111_1330.ECO111_2492,iECO26_1355.ECO26_2804,iECOK1_1307.ECOK1_2029,iECP_1309.ECP_1852,iECS88_1305.ECS88_1966,iECSF_1327.ECSF_1764,iECSP_1301.ECSP_2516,iECUMN_1333.ECUMN_2204,iECs_1301.ECs2650,iETEC_1333.ETEC_2020,iEcDH1_1363.EcDH1_1734,iEcE24377_1341.EcE24377A_2145,iEcHS_1320.EcHS_A2010,iEcSMS35_1347.EcSMS35_1271,iEcolC_1368.EcolC_1727,iG2583_1286.G2583_2363,iJO1366.b1912,iJR904.b1912,iLF82_1304.LF82_1635,iNRG857_1313.NRG857_09550,iSDY_1059.SDY_1106,iSSON_1240.SSON_1206,iSbBS512_1146.SbBS512_E1039,iUMN146_1321.UM146_07620,iUMNK88_1353.UMNK88_2386,iUTI89_1310.UTI89_C2113,iY75_1357.Y75_RS10025,iYL1228.KPN_02410,iZ_1308.Z3000,ic_1306.c2325	CDP-OH_P_transf
k59_539460_2	765913.ThidrDRAFT_2043	9.65e-71	232.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1WWEF@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_1536952_1	56780.SYN_02657	2.25e-81	254.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,42TG6@68525|delta/epsilon subdivisions,2WQ8T@28221|Deltaproteobacteria,2MRYG@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_1655476_1	278957.ABEA03000096_gene4628	3.83e-22	97.1	COG0860@1|root,COG0860@2|Bacteria,46SS7@74201|Verrucomicrobia,3K7YX@414999|Opitutae	414999|Opitutae	M	cell wall hydrolase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
k59_1307713_1	314278.NB231_09323	1.61e-26	108.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1WWD1@135613|Chromatiales	135613|Chromatiales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_1307713_2	360094.PXO_04097	8.14e-17	85.5	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1X4K0@135614|Xanthomonadales	135614|Xanthomonadales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_1185738_1	1396141.BATP01000020_gene84	1.24e-73	253.0	COG2010@1|root,COG2133@1|root,COG3506@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,COG3506@2|Bacteria,46TW3@74201|Verrucomicrobia,2IVDX@203494|Verrucomicrobiae	74201|Verrucomicrobia	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,GSDH,Laminin_G_3
k59_597830_1	1049564.TevJSym_ai00210	8.7e-91	282.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1J4VX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
k59_597830_2	95619.PM1_0205700	2.78e-56	187.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
k59_1420693_1	472759.Nhal_3019	6.99e-191	551.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1WVYF@135613|Chromatiales	135613|Chromatiales	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1246726_1	314345.SPV1_04928	5.42e-120	376.0	28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria	1224|Proteobacteria	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
k59_19060_1	1366050.N234_36240	2.91e-39	138.0	COG5486@1|root,COG5486@2|Bacteria,1NFSK@1224|Proteobacteria,2VZZR@28216|Betaproteobacteria,1KI9K@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Predicted metal-binding integral membrane protein (DUF2182)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2182
k59_19060_2	574966.KB898646_gene3218	5.94e-15	73.2	COG0671@1|root,COG0671@2|Bacteria,1RDK3@1224|Proteobacteria,1SYVW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
k59_833093_1	590998.Celf_2866	1.38e-95	292.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria,4F0RB@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM peptidase M20	amiA	-	-	ko:K01436,ko:K06048	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
k59_833093_2	590998.Celf_2867	1.6e-68	220.0	COG0836@1|root,COG0836@2|Bacteria,2GIRM@201174|Actinobacteria,4F20H@85016|Cellulomonadaceae	201174|Actinobacteria	M	Nucleotidyl transferase	manC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_896600_1	648757.Rvan_0603	2.12e-65	215.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,2TRJC@28211|Alphaproteobacteria,3N682@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
k59_896600_2	713587.THITH_11960	1.79e-43	144.0	COG2920@1|root,COG2920@2|Bacteria,1RISY@1224|Proteobacteria,1S8HB@1236|Gammaproteobacteria,1WYQ6@135613|Chromatiales	135613|Chromatiales	P	Part of a sulfur-relay system	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
k59_715906_1	153948.NAL212_0013	3.47e-76	233.0	COG3676@1|root,COG3676@2|Bacteria,1QTF7@1224|Proteobacteria,2VSUV@28216|Betaproteobacteria	28216|Betaproteobacteria	L	ISXO2-like transposase domain	-	-	-	ko:K07488	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1595
k59_19070_1	390235.PputW619_1517	9.88e-43	150.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,1YWZP@136845|Pseudomonas putida group	1236|Gammaproteobacteria	G	Responsible for synthesis of pseudouridine from uracil	rluC	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_772503_1	264198.Reut_A0497	1.16e-23	104.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,1K0D0@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
k59_1007442_1	1265505.ATUG01000002_gene2768	8.16e-44	161.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,42N34@68525|delta/epsilon subdivisions,2WJUD@28221|Deltaproteobacteria,2MI31@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	iAF987.Gmet_2474	OstA,OstA_2,OstA_C
k59_1361023_1	880072.Desac_2451	5.99e-84	259.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,42MQT@68525|delta/epsilon subdivisions,2WIP1@28221|Deltaproteobacteria,2MQBR@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_128951_1	935848.JAEN01000047_gene1018	7.28e-85	266.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2PW8K@265|Paracoccus	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	MA20_10900	-	-	-	-	-	-	-	-	-	-	-	rve
k59_480670_1	446466.Cfla_0987	1.59e-207	590.0	COG1217@1|root,COG1217@2|Bacteria,2GJUJ@201174|Actinobacteria,4F0JZ@85016|Cellulomonadaceae	201174|Actinobacteria	T	elongation factor Tu domain 2 protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_19090_1	247490.KSU1_D0557	3.59e-20	87.4	COG3065@1|root,COG3065@2|Bacteria	2|Bacteria	M	identical protein binding	slp	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802	-	ko:K07285	-	-	-	-	ko00000	-	-	-	Slp
k59_1246754_1	713587.THITH_10625	5.42e-69	219.0	COG0430@1|root,COG0430@2|Bacteria,1MX7Q@1224|Proteobacteria,1RSFF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	A	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009975,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
k59_896614_1	937777.Deipe_0968	1.17e-109	341.0	COG1132@1|root,COG1132@2|Bacteria,1WIMR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
k59_252721_1	110319.CF8_4214	4.51e-97	294.0	COG1680@1|root,COG1680@2|Bacteria,2H2SY@201174|Actinobacteria,4DRVE@85009|Propionibacteriales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1835976_1	1472716.KBK24_0102665	1.26e-50	172.0	COG0329@1|root,COG0329@2|Bacteria,1MXM5@1224|Proteobacteria,2VIKK@28216|Betaproteobacteria,1K06U@119060|Burkholderiaceae	28216|Betaproteobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_421906_1	396588.Tgr7_2124	1.25e-61	215.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1WWH2@135613|Chromatiales	135613|Chromatiales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_187655_1	1451261.AS96_04435	4.08e-120	369.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria	201174|Actinobacteria	P	Heavy metal translocating P-type atpase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k59_480679_2	1278307.KB906970_gene1075	2.31e-40	139.0	COG1959@1|root,COG1959@2|Bacteria,1N05H@1224|Proteobacteria,1S8SJ@1236|Gammaproteobacteria,2QIDK@267894|Psychromonadaceae	1236|Gammaproteobacteria	K	Transcriptional regulator	nsrR	-	-	ko:K13771	ko05132,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	Rrf2
k59_1185777_1	981384.AEYW01000014_gene146	7.94e-47	164.0	COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,2U0BA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B,Lactamase_B_2
k59_1071266_1	1384054.N790_03570	1.49e-107	327.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1X36F@135614|Xanthomonadales	135614|Xanthomonadales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_304537_1	395961.Cyan7425_0645	5.22e-11	62.0	COG2954@1|root,COG2954@2|Bacteria,1G5NQ@1117|Cyanobacteria,3KI11@43988|Cyanothece	1117|Cyanobacteria	S	Adenylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CYTH
k59_1011772_2	713586.KB900536_gene42	9.08e-61	205.0	COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,1TK7U@1236|Gammaproteobacteria,1X089@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8
k59_776796_1	1232410.KI421421_gene3874	1.16e-92	276.0	COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,42QT6@68525|delta/epsilon subdivisions,2WNC5@28221|Deltaproteobacteria,43W1X@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2238)	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
k59_1315266_1	471853.Bcav_1907	3.77e-35	126.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria	201174|Actinobacteria	M	Oxidoreductase molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
k59_1315266_2	1304865.JAGF01000001_gene3034	7.88e-220	615.0	COG3200@1|root,COG3200@2|Bacteria,2GJBX@201174|Actinobacteria,4F0WD@85016|Cellulomonadaceae	201174|Actinobacteria	E	Belongs to the class-II DAHP synthase family	aroG	GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016043,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0022607,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901576	2.5.1.54	ko:K01626,ko:K16019	ko00400,ko01051,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01051,map01100,map01110,map01130,map01230,map02024	M00022	R01826,R06591	RC00435,RC01556	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2178c	DAHP_synth_2
k59_259896_2	1121957.ATVL01000010_gene597	2.4e-89	279.0	COG0531@1|root,COG0531@2|Bacteria,4NH7J@976|Bacteroidetes,47NNC@768503|Cytophagia	976|Bacteroidetes	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_1843450_1	247633.GP2143_15196	4.61e-91	281.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1J4SX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	gltP	-	-	ko:K03309	-	-	-	-	ko00000	2.A.23	-	-	SDF
k59_427135_1	367299.JOEE01000002_gene2341	3.64e-45	162.0	COG0768@1|root,COG0768@2|Bacteria,2GJAM@201174|Actinobacteria,4FEVD@85021|Intrasporangiaceae	201174|Actinobacteria	M	Penicillin-binding Protein dimerisation domain	pbp2B	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	MecA_N,PBP_dimer,Transpeptidase
k59_904117_1	472759.Nhal_3430	1.4e-149	440.0	COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1WX8Q@135613|Chromatiales	135613|Chromatiales	M	Cell wall hydrolase autolysin	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,LysM
k59_963098_1	396588.Tgr7_0824	4.71e-14	71.2	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,1WWB1@135613|Chromatiales	135613|Chromatiales	T	SMART Nucleotide binding protein, PINc	-	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
k59_963098_2	765913.ThidrDRAFT_3346	1.19e-69	214.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,1RQ7F@1236|Gammaproteobacteria,1WY4F@135613|Chromatiales	135613|Chromatiales	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_1191084_1	335543.Sfum_2957	3.25e-94	300.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42N22@68525|delta/epsilon subdivisions,2WIMH@28221|Deltaproteobacteria,2MQBA@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
k59_193003_1	583355.Caka_2526	2.28e-87	278.0	COG2838@1|root,COG2838@2|Bacteria,46TNM@74201|Verrucomicrobia,3K755@414999|Opitutae	414999|Opitutae	C	Isocitrate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	IDH
k59_838360_1	266117.Rxyl_2529	5.03e-122	388.0	COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4CPJ1@84995|Rubrobacteria	84995|Rubrobacteria	E	Bacterial NAD-glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
k59_1315292_1	1026882.MAMP_02884	2.04e-43	153.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,45ZRY@72273|Thiotrichales	72273|Thiotrichales	E	TIGRFAM glutamine synthetase, type I	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_1718361_1	316067.Geob_1062	1.39e-10	61.6	COG1541@1|root,COG1541@2|Bacteria,1MXF5@1224|Proteobacteria,42MZA@68525|delta/epsilon subdivisions,2WIUC@28221|Deltaproteobacteria,43S2I@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	AMP-binding enzyme C-terminal domain	paaK-3	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
k59_1718361_2	335543.Sfum_0382	2.74e-32	126.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42MSQ@68525|delta/epsilon subdivisions,2WISJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK-1	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
k59_134352_1	557598.LHK_00642	6.73e-78	243.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,2KQ4C@206351|Neisseriales	206351|Neisseriales	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
k59_134352_2	1037409.BJ6T_38710	0.000225	42.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2U74V@28211|Alphaproteobacteria,3JY09@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
k59_1366516_1	177437.HRM2_47060	2.01e-64	207.0	COG0500@1|root,COG0500@2|Bacteria,1QW86@1224|Proteobacteria,42N1Q@68525|delta/epsilon subdivisions,2WJJS@28221|Deltaproteobacteria,2MJ72@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
k59_309827_1	375286.mma_0303	1.22e-58	186.0	COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,2VR31@28216|Betaproteobacteria,474FN@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
k59_309827_2	498211.CJA_3656	1.96e-49	167.0	COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,1RMKF@1236|Gammaproteobacteria,1FFY0@10|Cellvibrio	1236|Gammaproteobacteria	E	Alpha/beta hydrolase family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
k59_1011797_2	1249627.D779_1383	1.27e-44	145.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,1WYVD@135613|Chromatiales	135613|Chromatiales	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
k59_1011797_3	1249627.D779_1384	1.26e-50	162.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,1S5VB@1236|Gammaproteobacteria,1WYVV@135613|Chromatiales	135613|Chromatiales	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
k59_838370_1	1172186.KB911470_gene3152	1.57e-99	321.0	COG5412@1|root,COG5412@2|Bacteria,2IB04@201174|Actinobacteria,237Q0@1762|Mycobacteriaceae	201174|Actinobacteria	S	phage tail tape measure protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1843496_1	1121937.AUHJ01000002_gene3472	1.3e-19	92.4	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,4648Z@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
k59_904160_1	1123228.AUIH01000012_gene88	2.44e-44	160.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1XH7W@135619|Oceanospirillales	135619|Oceanospirillales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_904160_2	1380387.JADM01000004_gene2888	7.03e-110	325.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,1XHG1@135619|Oceanospirillales	135619|Oceanospirillales	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
k59_1315319_1	1280946.HY29_03615	4.45e-29	113.0	COG0346@1|root,COG0346@2|Bacteria,1RDMC@1224|Proteobacteria,2V78F@28211|Alphaproteobacteria,43ZC3@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1776866_1	558884.JRGM01000144_gene1551	3.74e-23	102.0	COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,1RZ65@1236|Gammaproteobacteria,1Y5QN@135624|Aeromonadales	135624|Aeromonadales	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
k59_1366532_1	395493.BegalDRAFT_1067	3.54e-30	117.0	COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,1RRNM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	nitrate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_721274_1	933262.AXAM01000053_gene2713	2.17e-167	490.0	COG4770@1|root,COG5016@1|root,COG4770@2|Bacteria,COG5016@2|Bacteria,1P6RE@1224|Proteobacteria,43BQE@68525|delta/epsilon subdivisions,2X71H@28221|Deltaproteobacteria,2MHKV@213118|Desulfobacterales	28221|Deltaproteobacteria	CI	Conserved carboxylase domain	-	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
k59_662646_2	1150469.RSPPHO_00122	1.33e-52	186.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,2JQVG@204441|Rhodospirillales	204441|Rhodospirillales	O	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_1129638_1	318167.Sfri_2280	7.33e-11	61.2	2EV95@1|root,33NPU@2|Bacteria,1NGQB@1224|Proteobacteria,1SGYD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1129638_2	1238182.C882_4238	7.38e-10	60.1	COG1863@1|root,COG1863@2|Bacteria,1MZYJ@1224|Proteobacteria,2UBYN@28211|Alphaproteobacteria,2JTMZ@204441|Rhodospirillales	204441|Rhodospirillales	P	Na+/H+ ion antiporter subunit	-	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
k59_427178_1	1123065.ATWL01000001_gene371	8.05e-35	140.0	COG1403@1|root,COG1403@2|Bacteria,2GP2N@201174|Actinobacteria	201174|Actinobacteria	V	HNH endonuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
k59_838386_1	1049564.TevJSym_aj00050	5.12e-42	145.0	28HN6@1|root,2Z7WJ@2|Bacteria,1R5QB@1224|Proteobacteria,1RNJN@1236|Gammaproteobacteria,1J92F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1011820_1	590998.Celf_1186	4.92e-115	346.0	COG0366@1|root,COG0366@2|Bacteria,2GNEC@201174|Actinobacteria	201174|Actinobacteria	G	Alpha amylase, catalytic domain	gtfA	-	2.4.1.7	ko:K00690	ko00500,map00500	-	R00803	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF1964
k59_1600767_1	768671.ThimaDRAFT_4072	7.02e-80	252.0	28KQH@1|root,2ZA8A@2|Bacteria,1R5EQ@1224|Proteobacteria,1RRD9@1236|Gammaproteobacteria,1WXTM@135613|Chromatiales	135613|Chromatiales	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
k59_1426108_1	187272.Mlg_2399	3.35e-64	211.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WX5F@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_1426108_2	1248232.BANQ01000013_gene997	9.29e-29	114.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1XTCY@135623|Vibrionales	135623|Vibrionales	U	general secretion pathway protein	epsF	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
k59_1129642_1	1254432.SCE1572_39625	1.15e-60	202.0	COG3039@1|root,COG3039@2|Bacteria,1Q3I2@1224|Proteobacteria,42XM0@68525|delta/epsilon subdivisions,2WSIG@28221|Deltaproteobacteria,2YZ3N@29|Myxococcales	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_603089_1	1121033.AUCF01000021_gene2817	8.57e-72	231.0	COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2TWCZ@28211|Alphaproteobacteria,2JYV3@204441|Rhodospirillales	204441|Rhodospirillales	CI	phosphate acetyltransferase	-	-	2.3.1.19,2.3.1.8	ko:K00625,ko:K00634	ko00430,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921,R01174	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas,PTA_PTB
k59_603089_2	159450.NH14_31500	1.2e-10	61.6	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2VHRC@28216|Betaproteobacteria,1K1WI@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
k59_662656_1	1283300.ATXB01000001_gene777	2.32e-105	308.0	COG1230@1|root,COG1230@2|Bacteria,1MUSS@1224|Proteobacteria,1RQ3M@1236|Gammaproteobacteria,1XG51@135618|Methylococcales	135618|Methylococcales	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
k59_662656_2	765911.Thivi_4489	4.01e-37	141.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1WX4B@135613|Chromatiales	135613|Chromatiales	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_1718403_1	1333998.M2A_2862	1.52e-24	102.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2TS5I@28211|Alphaproteobacteria,4BPKZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Peptidogalycan biosysnthesis/recognition	MA20_36195	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
k59_427189_1	1121861.KB899919_gene2695	7.85e-32	119.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2U5B1@28211|Alphaproteobacteria,2JRR1@204441|Rhodospirillales	204441|Rhodospirillales	P	COG0725 ABC-type molybdate transport system, periplasmic component	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
k59_427189_2	1123368.AUIS01000019_gene1205	5.67e-134	392.0	COG3608@1|root,COG3608@2|Bacteria,1R784@1224|Proteobacteria,1RRY6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM Succinylglutamate desuccinylase Aspartoacylase	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
k59_82376_2	679197.HMPREF9336_01924	2.21e-59	187.0	COG0824@1|root,COG0824@2|Bacteria,2IJV6@201174|Actinobacteria	201174|Actinobacteria	S	Thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
k59_1011832_2	68170.KL590496_gene9300	2.05e-14	72.0	COG3544@1|root,COG3544@2|Bacteria,2IKUE@201174|Actinobacteria,4E4DB@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF305)	-	-	-	-	-	-	-	-	-	-	-	-	DUF305
k59_603101_1	335659.S23_47630	3.46e-60	202.0	COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,2TTBA@28211|Alphaproteobacteria,3JX1U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_309873_1	644107.SL1157_3165	5.01e-25	106.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria,4N9Y6@97050|Ruegeria	28211|Alphaproteobacteria	MU	Outer membrane efflux protein	oprN	-	-	ko:K18300,ko:K19593	-	M00641,M00769	-	-	ko00000,ko00002,ko01504,ko02000	1.B.17,2.A.6.2.34	-	-	OEP
k59_904209_1	713586.KB900536_gene1602	5.75e-81	254.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1WWC9@135613|Chromatiales	135613|Chromatiales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_1366560_1	357808.RoseRS_1961	1.63e-65	214.0	COG0065@1|root,COG0065@2|Bacteria,2G68G@200795|Chloroflexi,3753P@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_1366560_2	290397.Adeh_1979	4.85e-25	98.2	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,42QN7@68525|delta/epsilon subdivisions,2WP27@28221|Deltaproteobacteria,2YVXG@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_427195_1	96561.Dole_1884	2.57e-102	307.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42M4C@68525|delta/epsilon subdivisions,2WJ1Q@28221|Deltaproteobacteria,2MI8P@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
k59_485984_1	1278309.KB907102_gene163	2.03e-26	101.0	COG2824@1|root,COG2824@2|Bacteria,1N1JG@1224|Proteobacteria,1S98R@1236|Gammaproteobacteria,1XKGA@135619|Oceanospirillales	135619|Oceanospirillales	P	Alkylphosphonate utilization operon protein PhnA	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_375968_1	314278.NB231_03827	3.66e-74	226.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,1WWTG@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM NADH-quinone oxidoreductase, E subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_1661005_1	545264.KB898749_gene96	7.04e-171	503.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM NADH-quinone oxidoreductase, chain G	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_134408_1	883126.HMPREF9710_00782	1.68e-71	225.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2VI1H@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_82394_2	452637.Oter_1466	1.4e-28	115.0	COG0243@1|root,COG0243@2|Bacteria,46U1H@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_1011845_2	742741.HMPREF9475_03080	4.11e-34	122.0	COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia,21ZYM@1506553|Lachnoclostridium	186801|Clostridia	G	Ribose 5-phosphate isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
k59_904229_1	675635.Psed_5861	1.15e-41	155.0	COG3158@1|root,COG3158@2|Bacteria,2GMPQ@201174|Actinobacteria,4E0FX@85010|Pseudonocardiales	201174|Actinobacteria	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_485995_1	525897.Dbac_1087	5.11e-27	103.0	2E8QN@1|root,3331M@2|Bacteria,1ND4I@1224|Proteobacteria,430TR@68525|delta/epsilon subdivisions,2WVZ7@28221|Deltaproteobacteria,2MF52@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_485995_2	525897.Dbac_1088	0.000172	42.4	2ADPE@1|root,313EG@2|Bacteria,1NEWZ@1224|Proteobacteria,42V0P@68525|delta/epsilon subdivisions,2WSFD@28221|Deltaproteobacteria,2MFC5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp
k59_1011850_1	1120954.ATXE01000002_gene948	9.12e-81	251.0	COG2021@1|root,COG2021@2|Bacteria,2GKNJ@201174|Actinobacteria,4DNSW@85009|Propionibacteriales	201174|Actinobacteria	E	Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	metX	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_603126_1	591001.Acfer_0931	2.1e-44	162.0	COG0126@1|root,COG0149@1|root,COG0126@2|Bacteria,COG0149@2|Bacteria,1TP3H@1239|Firmicutes,4H2GV@909932|Negativicutes	909932|Negativicutes	G	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK,TIM
k59_1843582_1	289376.THEYE_A0743	6.9e-72	230.0	COG2204@1|root,COG2204@2|Bacteria,3J10B@40117|Nitrospirae	40117|Nitrospirae	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1079734_1	1121004.ATVC01000074_gene1223	5.7e-42	140.0	COG1943@1|root,COG1943@2|Bacteria,1RDD7@1224|Proteobacteria,2VS0W@28216|Betaproteobacteria,2KSYT@206351|Neisseriales	206351|Neisseriales	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
k59_486002_1	935557.ATYB01000014_gene4274	3.78e-147	431.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,4B81G@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_603127_1	7668.SPU_021440-tr	5.59e-47	172.0	2D57X@1|root,2SXP9@2759|Eukaryota,3AFPT@33154|Opisthokonta,3BZ8I@33208|Metazoa	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_A17
k59_776875_1	1177154.Y5S_01122	7.11e-18	85.1	COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,1XK8K@135619|Oceanospirillales	135619|Oceanospirillales	S	High frequency lysogenization protein HflD homolog	hflD	-	-	ko:K07153	-	-	-	-	ko00000	-	-	-	DUF489
k59_1191853_1	1266925.JHVX01000012_gene1688	8.22e-07	47.0	COG3360@1|root,COG3360@2|Bacteria,1PW6C@1224|Proteobacteria,2VXDE@28216|Betaproteobacteria,373H6@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
k59_1191853_2	96561.Dole_1336	1.55e-55	184.0	COG1102@1|root,COG1102@2|Bacteria,1R9XZ@1224|Proteobacteria,42R78@68525|delta/epsilon subdivisions,2WN7X@28221|Deltaproteobacteria,2MJR4@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
k59_964165_1	497321.C664_03690	1.31e-110	328.0	COG0189@1|root,COG0189@2|Bacteria,1MV29@1224|Proteobacteria,2VNDY@28216|Betaproteobacteria	28216|Betaproteobacteria	HJ	Prokaryotic glutathione synthetase, ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	GSH-S_ATP
k59_83342_1	870187.Thini_0582	3.15e-14	77.4	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,462DX@72273|Thiotrichales	72273|Thiotrichales	M	PFAM Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_1012457_1	1267005.KB911259_gene3881	1.1e-53	172.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2UBYM@28211|Alphaproteobacteria,3N7AJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Thioesterase-like superfamily	ybgC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
k59_1012457_2	501479.ACNW01000080_gene4573	2.59e-23	97.4	COG2354@1|root,COG2354@2|Bacteria,1MVYU@1224|Proteobacteria,2TU43@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	yedI	-	-	ko:K09781	-	-	-	-	ko00000	-	-	-	DUF808
k59_1426845_1	497964.CfE428DRAFT_5370	3.84e-92	279.0	COG2255@1|root,COG2255@2|Bacteria,46SDS@74201|Verrucomicrobia	74201|Verrucomicrobia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_384219_1	1121459.AQXE01000001_gene2528	7.78e-83	277.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria,2M7VS@213115|Desulfovibrionales	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_4,PAS_9,Response_reg,Sigma54_activat
k59_971570_1	768671.ThimaDRAFT_4835	6.03e-85	255.0	COG1595@1|root,COG1595@2|Bacteria,1MVS7@1224|Proteobacteria,1S9FF@1236|Gammaproteobacteria,1WZCY@135613|Chromatiales	135613|Chromatiales	K	sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_1261166_2	768670.Calni_1535	1.93e-17	74.3	COG0267@1|root,COG0267@2|Bacteria,2GFZW@200930|Deferribacteres	200930|Deferribacteres	J	Ribosomal protein L33	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
k59_1261166_3	1232437.KL662045_gene2156	1.31e-07	52.0	COG0690@1|root,COG0690@2|Bacteria,1Q1BI@1224|Proteobacteria,42X4Z@68525|delta/epsilon subdivisions,2WSQ8@28221|Deltaproteobacteria,2MKUQ@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
k59_1782409_1	652103.Rpdx1_2144	4.62e-59	189.0	COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria,2VEYC@28211|Alphaproteobacteria,3JTAQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_1782409_2	744979.R2A130_0179	8.22e-12	64.7	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2TSWQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_1724190_1	765912.Thimo_2166	1.01e-78	253.0	COG1132@1|root,COG1132@2|Bacteria,1N1Z8@1224|Proteobacteria,1RPVC@1236|Gammaproteobacteria,1WWAF@135613|Chromatiales	135613|Chromatiales	V	ABC transporter transmembrane region	-	-	-	ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1	-	-	ABC_membrane,ABC_tran
k59_844112_1	1280953.HOC_17531	2.29e-173	493.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2TQM7@28211|Alphaproteobacteria,43W5N@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_844113_1	1123514.KB905902_gene287	2.03e-81	253.0	COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,1RYFC@1236|Gammaproteobacteria,460S7@72273|Thiotrichales	72273|Thiotrichales	T	HPP family	-	-	-	-	-	-	-	-	-	-	-	-	HPP
k59_1135071_2	192952.MM_1528	3.07e-29	117.0	COG1048@1|root,arCOG01697@2157|Archaea,2XTIZ@28890|Euryarchaeota,2NAHN@224756|Methanomicrobia	224756|Methanomicrobia	C	Aconitase C-terminal domain	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0714	Aconitase,Aconitase_C
k59_912545_1	1184267.A11Q_1340	5.91e-126	370.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2MSRZ@213481|Bdellovibrionales,2WJ3Z@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	acyl-coa dehydrogenase	bcd	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_912545_2	1121447.JONL01000001_gene351	4.03e-05	42.4	COG1826@1|root,COG1826@2|Bacteria,1NGDP@1224|Proteobacteria,42V5P@68525|delta/epsilon subdivisions,2WRM0@28221|Deltaproteobacteria,2MD43@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_35955_1	1158292.JPOE01000002_gene2121	3.31e-87	271.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2VH9X@28216|Betaproteobacteria,1KIYR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
k59_384261_1	880074.BARVI_00275	6.2e-06	47.8	COG2022@1|root,COG2022@2|Bacteria,4NDWY@976|Bacteroidetes,2FP7B@200643|Bacteroidia,22WR6@171551|Porphyromonadaceae	976|Bacteroidetes	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
k59_1724197_1	234267.Acid_1263	7.52e-62	203.0	COG1063@1|root,COG1063@2|Bacteria,3Y2H8@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_35957_1	349521.HCH_05144	5.58e-46	152.0	COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,1RPGA@1236|Gammaproteobacteria,1XJSJ@135619|Oceanospirillales	135619|Oceanospirillales	K	Transcriptional	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24
k59_35957_2	1120970.AUBZ01000029_gene1048	2.99e-41	149.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,4656N@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_844118_1	1268303.RHODMAR_4940	1.09e-09	64.3	COG1674@1|root,COG1674@2|Bacteria,2HHTH@201174|Actinobacteria,4G0DK@85025|Nocardiaceae	201174|Actinobacteria	D	FtsK/SpoIIIE family	-	-	-	-	-	-	-	-	-	-	-	-	FtsK_SpoIIIE
k59_1196927_1	999541.bgla_1g09590	3.49e-19	85.1	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2VH5M@28216|Betaproteobacteria,1K05V@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_1196927_2	1032480.MLP_01910	9.75e-31	121.0	COG0366@1|root,COG0366@2|Bacteria,2GNEC@201174|Actinobacteria,4DUSN@85009|Propionibacteriales	201174|Actinobacteria	G	Alpha amylase, catalytic domain	gtfA	-	2.4.1.7	ko:K00690	ko00500,map00500	-	R00803	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF1964
k59_608875_1	1049564.TevJSym_bc00390	1.28e-112	340.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,1JARP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Nickel-dependent hydrogenase	hydB	-	1.12.5.1,1.12.99.6	ko:K05922,ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_1323788_1	420324.KI911984_gene5121	1.12e-43	152.0	COG3547@1|root,COG3547@2|Bacteria,1QYJU@1224|Proteobacteria,2U1TU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1431958_1	713586.KB900536_gene605	1.16e-82	248.0	COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,1S21E@1236|Gammaproteobacteria,1WXCN@135613|Chromatiales	135613|Chromatiales	H	May be involved in the biosynthesis of molybdopterin	-	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
k59_1724206_1	1049564.TevJSym_aa02460	2.22e-22	100.0	28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,1RN0X@1236|Gammaproteobacteria,1J5BR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Fatty acid cis/trans isomerase (CTI)	cti	-	-	-	-	-	-	-	-	-	-	-	CTI
k59_35976_1	572477.Alvin_1201	1.7e-149	441.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales	135613|Chromatiales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_1666830_2	258594.RPA4374	2.01e-11	66.2	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria,3JRIY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the peptidase M16 family	MA20_05655	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_1371981_1	631362.Thi970DRAFT_01605	4.15e-18	81.6	COG0622@1|root,COG0622@2|Bacteria,1N8BH@1224|Proteobacteria,1S1KD@1236|Gammaproteobacteria,1WWKY@135613|Chromatiales	135613|Chromatiales	S	Phosphoesterase	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
k59_1371981_2	1121929.KB898666_gene2460	6.69e-17	77.0	COG3369@1|root,COG3369@2|Bacteria,1VFK3@1239|Firmicutes,4HNHY@91061|Bacilli	91061|Bacilli	S	SMART zinc finger CDGSH-type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
k59_1371981_3	555088.DealDRAFT_0494	0.000481	42.0	COG0471@1|root,COG0471@2|Bacteria,1TSP2@1239|Firmicutes,24DU3@186801|Clostridia	186801|Clostridia	P	TIGRFAM anion transporter	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
k59_269535_1	395493.BegalDRAFT_2152	2.73e-11	62.4	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,1RMTR@1236|Gammaproteobacteria,45ZYX@72273|Thiotrichales	72273|Thiotrichales	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_269535_2	935839.JAGJ01000002_gene826	1.07e-76	238.0	COG1091@1|root,COG1091@2|Bacteria,2GNY8@201174|Actinobacteria,4F3XY@85017|Promicromonosporaceae	201174|Actinobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rmlD	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
k59_1606078_2	1255043.TVNIR_1079	2.24e-07	50.4	COG0607@1|root,COG0607@2|Bacteria,1RKAQ@1224|Proteobacteria,1SC2Q@1236|Gammaproteobacteria,1X1H4@135613|Chromatiales	135613|Chromatiales	P	Rhodanese-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_781813_1	177439.DP1199	2.06e-41	147.0	COG1014@1|root,COG1144@1|root,COG1014@2|Bacteria,COG1144@2|Bacteria,1N12F@1224|Proteobacteria,42NN1@68525|delta/epsilon subdivisions,2WQFN@28221|Deltaproteobacteria,2MKTB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,POR
k59_1196943_1	1121035.AUCH01000003_gene1160	1.52e-76	244.0	COG3863@1|root,COG3863@2|Bacteria,1R3R2@1224|Proteobacteria,2VRR0@28216|Betaproteobacteria,2KYEG@206389|Rhodocyclales	206389|Rhodocyclales	S	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C92
k59_844138_1	367299.JOEE01000008_gene630	1.49e-108	324.0	COG0215@1|root,COG0215@2|Bacteria,2GJZR@201174|Actinobacteria,4FEEX@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins	mshC	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iNJ661.Rv2130c	tRNA-synt_1e
k59_726640_1	1242864.D187_006867	2.56e-21	99.4	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,2YXPT@29|Myxococcales	28221|Deltaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_1667497_1	187272.Mlg_2192	7.13e-66	215.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1WW6B@135613|Chromatiales	135613|Chromatiales	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1372612_1	446466.Cfla_2943	2.98e-24	94.4	COG3905@1|root,COG3905@2|Bacteria,2GWKG@201174|Actinobacteria	201174|Actinobacteria	K	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source	vapB43	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0071944	-	-	-	-	-	-	-	-	-	-	RHH_1
k59_1372612_2	446466.Cfla_2944	8.38e-49	159.0	COG1848@1|root,COG1848@2|Bacteria,2GPX7@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
k59_36881_1	754477.Q7C_1172	1.93e-16	79.3	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,4610F@72273|Thiotrichales	72273|Thiotrichales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
k59_36881_2	754477.Q7C_1173	7.61e-116	345.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,4608W@72273|Thiotrichales	72273|Thiotrichales	M	Lytic murein transglycosylase B	-	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
k59_316505_1	1123393.KB891317_gene2319	6.67e-81	245.0	COG3548@1|root,COG3548@2|Bacteria,1R9WQ@1224|Proteobacteria,2VQBM@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
k59_92079_1	396588.Tgr7_3011	1.14e-114	338.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1WX49@135613|Chromatiales	135613|Chromatiales	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
k59_1087778_1	765911.Thivi_3315	8.47e-105	316.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1WVVC@135613|Chromatiales	135613|Chromatiales	F	TIGRFAM dihydroorotase, multifunctional complex type	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_1087778_2	519989.ECTPHS_03929	6.98e-29	110.0	COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,1RQ7W@1236|Gammaproteobacteria,1X286@135613|Chromatiales	135613|Chromatiales	C	Oxidoreductase FAD-binding domain	-	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind
k59_1135693_1	472759.Nhal_2782	2.91e-82	268.0	COG0508@1|root,COG1249@1|root,COG0508@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1WWGK@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding,Pyr_redox_2,Pyr_redox_dim
k59_385551_1	1049564.TevJSym_at00260	8.21e-139	408.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1J4GC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	iECSE_1348.ECSE_3895,iJN746.PP_5056	Metalloenzyme,Phosphodiest,iPGM_N
k59_433516_1	383407.XOC_2032	3.73e-94	292.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1X3HB@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_1853365_1	768671.ThimaDRAFT_2276	9.33e-107	327.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1WW6M@135613|Chromatiales	135613|Chromatiales	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
k59_972876_1	717785.HYPMC_1157	1.76e-63	204.0	COG2267@1|root,COG2267@2|Bacteria,1R131@1224|Proteobacteria,2TYX6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_1667504_1	446469.Sked_13290	1.92e-80	252.0	COG1466@1|root,COG1466@2|Bacteria,2GNMZ@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
k59_609599_1	543728.Vapar_0725	8.45e-195	551.0	COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,2VRHD@28216|Betaproteobacteria,4AJA6@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_316515_2	497964.CfE428DRAFT_0539	6.2e-55	176.0	COG1403@1|root,COG1403@2|Bacteria,46SMP@74201|Verrucomicrobia	74201|Verrucomicrobia	L	HNH endonuclease	mcrA	-	-	-	-	-	-	-	-	-	-	-	HNH_5
k59_550906_1	1278309.KB907100_gene2164	1.71e-69	229.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1XIN2@135619|Oceanospirillales	135619|Oceanospirillales	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_199160_1	1452718.JBOY01000055_gene1733	1.87e-61	194.0	COG1704@1|root,COG1704@2|Bacteria,1R9YG@1224|Proteobacteria,1T06D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
k59_1372637_2	1304865.JAGF01000001_gene564	1.89e-48	166.0	COG4974@1|root,COG4974@2|Bacteria,2HD2H@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1432660_1	1304865.JAGF01000001_gene2774	1.51e-59	194.0	COG0789@1|root,COG0789@2|Bacteria,2H5GI@201174|Actinobacteria,4F0WH@85016|Cellulomonadaceae	201174|Actinobacteria	K	TipAS antibiotic-recognition domain	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,TipAS
k59_1606716_1	1158292.JPOE01000002_gene2840	1.79e-25	105.0	COG2211@1|root,COG5309@1|root,COG2211@2|Bacteria,COG5309@2|Bacteria,1MWJJ@1224|Proteobacteria,2VIIU@28216|Betaproteobacteria	28216|Betaproteobacteria	G	beta (1-6) glucans synthase	-	-	3.2.1.58	ko:K01210	ko00500,map00500	-	R00308,R03115	RC00467	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_17
k59_1372644_1	1323663.AROI01000013_gene230	8.54e-46	154.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Riboflavin synthase	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
k59_1372644_2	1249627.D779_1799	1.93e-79	246.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1WW6K@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_727332_2	717785.HYPMC_2103	3.82e-52	169.0	COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,2TW0S@28211|Alphaproteobacteria,3N7A3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_385609_1	1267005.KB911265_gene3597	4.56e-45	166.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,3N6H7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	PD-(D/E)XK nuclease superfamily	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
k59_433551_2	1385520.N802_14210	3.19e-34	128.0	COG4585@1|root,COG4585@2|Bacteria,2GJ4J@201174|Actinobacteria,4FER4@85021|Intrasporangiaceae	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_1496435_1	883126.HMPREF9710_01128	1.9e-72	232.0	COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,2VH73@28216|Betaproteobacteria,476PV@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Putative aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Aminopep
k59_1087821_1	1229909.NSED_00015	5.94e-63	202.0	COG0648@1|root,arCOG01894@2157|Archaea,41SDW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
k59_492361_1	1280954.HPO_01455	9.84e-91	278.0	COG3033@1|root,COG3033@2|Bacteria,1NG5U@1224|Proteobacteria,2TTAU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	catalyzes the formation of indole and pyruvate from tryptophan	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_1853438_1	1397528.Q671_16160	3.61e-41	149.0	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,1RN0G@1236|Gammaproteobacteria,1XP31@135619|Oceanospirillales	135619|Oceanospirillales	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_913930_1	467200.ACFA01000352_gene2312	4.03e-15	71.2	COG0295@1|root,COG0295@2|Bacteria,2IHP7@201174|Actinobacteria	201174|Actinobacteria	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	GO:0003674,GO:0003824,GO:0004126,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006213,GO:0006216,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008655,GO:0009056,GO:0009058,GO:0009112,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009972,GO:0009987,GO:0016020,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019856,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042455,GO:0043094,GO:0043100,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046087,GO:0046108,GO:0046109,GO:0046112,GO:0046131,GO:0046132,GO:0046133,GO:0046134,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0047844,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0072529,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1,dCMP_cyt_deam_2
k59_913930_2	1385519.N801_17010	3.15e-65	210.0	COG0213@1|root,COG0213@2|Bacteria,2GJH5@201174|Actinobacteria,4FETB@85021|Intrasporangiaceae	201174|Actinobacteria	F	pyrimidine-nucleoside phosphorylase	deoA	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
k59_1611144_2	697282.Mettu_1439	3.83e-109	335.0	COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,1RN9V@1236|Gammaproteobacteria,1XE92@135618|Methylococcales	135618|Methylococcales	C	UPF0313 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
k59_1729527_1	545264.KB898750_gene308	3.57e-91	291.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1WWJI@135613|Chromatiales	135613|Chromatiales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_1333369_1	269799.Gmet_0408	9.35e-30	120.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,42MXF@68525|delta/epsilon subdivisions,2WIJZ@28221|Deltaproteobacteria,43TX6@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_1501397_1	446466.Cfla_2644	1.3e-102	299.0	COG0097@1|root,COG0097@2|Bacteria,2GK35@201174|Actinobacteria,4F206@85016|Cellulomonadaceae	201174|Actinobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
k59_1729533_2	1049564.TevJSym_bk00120	3.13e-29	110.0	COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria,1SAW8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	dksA traR	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
k59_614165_1	1205680.CAKO01000040_gene935	6.11e-141	410.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2TQM7@28211|Alphaproteobacteria,2JP9U@204441|Rhodospirillales	204441|Rhodospirillales	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_1501401_2	1123368.AUIS01000005_gene375	3.49e-14	70.9	COG1595@1|root,COG1595@2|Bacteria,1R9WC@1224|Proteobacteria,1SA30@1236|Gammaproteobacteria,2ND7J@225057|Acidithiobacillales	225057|Acidithiobacillales	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r4_2
k59_203746_1	1004785.AMBLS11_18225	6.9e-14	74.3	COG3031@1|root,COG3031@2|Bacteria,1RD3I@1224|Proteobacteria,1RQKA@1236|Gammaproteobacteria,465CV@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	General secretion pathway protein C	gspC	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K02452	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	PDZ_2,T2SSC
k59_203746_2	396588.Tgr7_0225	1.23e-23	101.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1WWUD@135613|Chromatiales	135613|Chromatiales	NU	general secretion pathway protein D	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k59_732016_1	1300345.LF41_816	1.84e-75	239.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1X36D@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_555502_1	2340.JV46_09560	6.57e-94	292.0	COG0475@1|root,COG0475@2|Bacteria,1RB9F@1224|Proteobacteria,1S398@1236|Gammaproteobacteria,1J6EW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	P COG0025 NhaP-type Na H and K H antiporters	-	-	-	ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37.1.2	-	-	Na_H_Exchanger
k59_555502_2	278957.ABEA03000046_gene1625	3.55e-105	317.0	COG3550@1|root,COG3550@2|Bacteria,46XT4@74201|Verrucomicrobia,3K8Y8@414999|Opitutae	414999|Opitutae	S	Pfam:HipA_N	-	-	2.7.11.1	ko:K07154	-	-	-	-	ko00000,ko01000,ko01001,ko02048	-	-	-	Couple_hipA,HipA_C
k59_1729538_1	1121468.AUBR01000084_gene783	4.64e-49	171.0	COG3547@1|root,COG3547@2|Bacteria,1TRSB@1239|Firmicutes,249AC@186801|Clostridia,42F47@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM transposase IS116 IS110 IS902	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1553015_1	1121456.ATVA01000012_gene2923	9.7e-24	94.7	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,42RZK@68525|delta/epsilon subdivisions,2WQ3C@28221|Deltaproteobacteria,2MB9Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Molybdopterin guanine dinucleotide synthesis protein B	mobB	-	2.7.7.77	ko:K03753,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	MobB,NTP_transf_3
k59_1553015_2	1283283.ATXA01000012_gene4816	7.74e-13	70.5	COG3842@1|root,COG3842@2|Bacteria,2H2JF@201174|Actinobacteria	201174|Actinobacteria	P	ABC transporter	modC	-	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
k59_1501406_1	313624.NSP_41170	7.88e-10	60.1	COG0068@1|root,COG0068@2|Bacteria,1G063@1117|Cyanobacteria,1HIEP@1161|Nostocales	1117|Cyanobacteria	O	TIGRFAM NiFe hydrogenase maturation protein HypF	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
k59_1611161_1	243233.MCA1439	4.69e-49	172.0	COG1208@1|root,COG2148@1|root,COG1208@2|Bacteria,COG2148@2|Bacteria,1MYXF@1224|Proteobacteria,1S89K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,NTP_transferase
k59_732019_1	330084.JNYZ01000068_gene8553	6.93e-46	167.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria	201174|Actinobacteria	EQ	PFAM Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k59_849297_1	666685.R2APBS1_0461	6.58e-70	229.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,1X53W@135614|Xanthomonadales	135614|Xanthomonadales	S	L,D-transpeptidase catalytic domain	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_321095_1	713586.KB900536_gene2168	1.42e-39	144.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1WYMY@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
k59_673465_1	187272.Mlg_1818	9.61e-35	126.0	COG2738@1|root,COG2738@2|Bacteria,1RDJH@1224|Proteobacteria,1S4QY@1236|Gammaproteobacteria,1X0PS@135613|Chromatiales	135613|Chromatiales	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K06973	-	-	-	-	ko00000	-	-	-	Zn_peptidase_2
k59_673465_2	857087.Metme_0789	1.89e-11	64.3	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,1XEWW@135618|Methylococcales	135618|Methylococcales	H	PFAM Rhodanese-like	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_43207_1	765910.MARPU_15605	1.1e-40	143.0	COG3187@1|root,COG3187@2|Bacteria,1R0YJ@1224|Proteobacteria,1T4RM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	O COG3187 Heat shock protein	-	-	-	-	-	-	-	-	-	-	-	-	META
k59_393716_1	794903.OPIT5_24415	3.54e-68	228.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,DUF4976,Sulfatase
k59_1377072_1	1324957.K933_08987	5.25e-34	127.0	COG1575@1|root,arCOG00480@2157|Archaea,2XT1M@28890|Euryarchaeota,23TNU@183963|Halobacteria	183963|Halobacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_1377072_2	65497.JODV01000007_gene534	1.86e-15	74.3	COG0447@1|root,COG0447@2|Bacteria,2GK5G@201174|Actinobacteria,4E09A@85010|Pseudonocardiales	201174|Actinobacteria	H	Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily	menB	-	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_922131_2	519989.ECTPHS_06082	2.11e-39	132.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,1WYJ2@135613|Chromatiales	135613|Chromatiales	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
k59_43214_1	1121403.AUCV01000003_gene1782	3.9e-120	362.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,42PV9@68525|delta/epsilon subdivisions,2WKF2@28221|Deltaproteobacteria,2MJW6@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	clsA	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
k59_1092828_1	1429916.X566_10330	7.47e-84	260.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,3JSJN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	dctM	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM,DctQ
k59_732033_1	649747.HMPREF0083_02525	1.85e-40	144.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,4HBEA@91061|Bacilli,26T8K@186822|Paenibacillaceae	91061|Bacilli	C	(E1) component, eukaryotic type, alpha subunit	acoA	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
k59_1021081_2	309807.SRU_0895	3.57e-24	103.0	COG0405@1|root,COG0405@2|Bacteria,4NF2H@976|Bacteroidetes,1FIXA@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Gamma-glutamyltranspeptidase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_1861730_1	765912.Thimo_0958	1.22e-72	230.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1WX3A@135613|Chromatiales	135613|Chromatiales	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_438195_1	929556.Solca_2421	2.54e-60	206.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,1INY1@117747|Sphingobacteriia	976|Bacteroidetes	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_922156_1	1121918.ARWE01000001_gene186	3.57e-46	165.0	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,42N4S@68525|delta/epsilon subdivisions,2WJXX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
k59_393740_1	207954.MED92_01729	9.52e-144	412.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1XH32@135619|Oceanospirillales	135619|Oceanospirillales	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_555532_1	1304872.JAGC01000009_gene1014	1.28e-57	191.0	COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,436PP@68525|delta/epsilon subdivisions,2X1BR@28221|Deltaproteobacteria,2MER0@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	cog1234, metal-dependent hydrolases of the beta-lactamase superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1729569_1	765910.MARPU_02430	9.67e-41	146.0	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,1RNUY@1236|Gammaproteobacteria,1WW69@135613|Chromatiales	135613|Chromatiales	G	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
k59_496943_1	349124.Hhal_0653	1.13e-11	63.9	COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1WW1X@135613|Chromatiales	135613|Chromatiales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
k59_496943_2	697282.Mettu_1303	5.44e-55	186.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1XEEP@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_438197_1	1211579.PP4_51530	8.36e-57	197.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1YWBP@136845|Pseudomonas putida group	1236|Gammaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_438197_2	1249627.D779_3815	6.54e-71	232.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales	135613|Chromatiales	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_276395_1	1430440.MGMSRv2_1428	3.08e-50	167.0	COG2863@1|root,COG2863@2|Bacteria,1R6DK@1224|Proteobacteria	1224|Proteobacteria	C	Pfam cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_732050_1	220341.16503831	3.25e-26	108.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,3ZKGI@590|Salmonella	1236|Gammaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_1553048_1	247639.MGP2080_08079	3.2e-146	422.0	COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,1RQZV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_1672135_1	1415779.JOMH01000001_gene1316	4.86e-37	136.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1X3ZU@135614|Xanthomonadales	135614|Xanthomonadales	U	General secretion pathway protein	xcsF	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
k59_1672135_3	187272.Mlg_1175	2.33e-56	198.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,1WW62@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1377101_1	471853.Bcav_4210	2.12e-29	121.0	COG0515@1|root,COG0728@1|root,COG3170@1|root,COG0515@2|Bacteria,COG0728@2|Bacteria,COG3170@2|Bacteria,2GKN0@201174|Actinobacteria	201174|Actinobacteria	KLT	Integral membrane protein MviN	mviN	GO:0003674,GO:0005215,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_1553060_1	768671.ThimaDRAFT_3413	1.67e-65	219.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1WWXP@135613|Chromatiales	135613|Chromatiales	J	small GTP-binding protein	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_100277_1	1133849.O3I_011180	1.96e-24	103.0	COG2267@1|root,COG2267@2|Bacteria,2GPA8@201174|Actinobacteria,4FW0U@85025|Nocardiaceae	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
k59_1267132_2	640081.Dsui_3448	5e-74	231.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2VHIS@28216|Betaproteobacteria,2KW1K@206389|Rhodocyclales	206389|Rhodocyclales	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483,ko:K07666	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1553545_2	96561.Dole_1055	9.49e-15	73.9	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,42NKH@68525|delta/epsilon subdivisions,2WJ30@28221|Deltaproteobacteria,2MIR5@213118|Desulfobacterales	28221|Deltaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_1553551_1	1279015.KB908454_gene687	6.56e-13	68.2	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1Y43R@135624|Aeromonadales	135624|Aeromonadales	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
k59_786719_2	864702.OsccyDRAFT_2347	3.72e-28	114.0	COG0438@1|root,COG0438@2|Bacteria,1G0Z5@1117|Cyanobacteria,1H7YK@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
k59_614721_1	1382304.JNIL01000001_gene1614	5.13e-55	199.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,4H9T3@91061|Bacilli,2786Y@186823|Alicyclobacillaceae	91061|Bacilli	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1437769_1	530564.Psta_4195	9.55e-92	300.0	COG0755@1|root,COG1333@1|root,COG0755@2|Bacteria,COG1333@2|Bacteria,2IY3J@203682|Planctomycetes	203682|Planctomycetes	O	Cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm,ResB
k59_1672695_1	717785.HYPMC_0545	4.25e-113	334.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2TSHK@28211|Alphaproteobacteria,3N61T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1334344_1	292415.Tbd_1253	1.43e-85	258.0	COG2210@1|root,COG2210@2|Bacteria,1QCK1@1224|Proteobacteria,2WE8S@28216|Betaproteobacteria,1KSAI@119069|Hydrogenophilales	119069|Hydrogenophilales	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
k59_1334344_2	498211.CJA_3656	1.03e-93	283.0	COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,1RMKF@1236|Gammaproteobacteria,1FFY0@10|Cellvibrio	1236|Gammaproteobacteria	E	Alpha/beta hydrolase family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
k59_1334345_1	452637.Oter_4283	8.1e-51	183.0	COG0657@1|root,COG0657@2|Bacteria,46TU9@74201|Verrucomicrobia,3KA3K@414999|Opitutae	414999|Opitutae	I	Glycosyl hydrolase family 65, N-terminal domain	-	-	3.2.1.51	ko:K15923	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000	-	GH95	-	Glyco_hyd_65N_2
k59_849846_2	573370.DMR_20450	4.58e-27	112.0	COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,42MA5@68525|delta/epsilon subdivisions,2WJGZ@28221|Deltaproteobacteria,2M9Y5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
k59_1437773_1	765910.MARPU_12540	9.39e-112	344.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1WW1J@135613|Chromatiales	135613|Chromatiales	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	-	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_277315_1	1906.SFRA_07635	5.35e-98	298.0	COG3344@1|root,COG3344@2|Bacteria,2GUJS@201174|Actinobacteria	201174|Actinobacteria	L	RNA-directed DNA polymerase (reverse transcriptase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_1611745_1	765912.Thimo_1228	2.25e-82	272.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWB8@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_849847_1	593907.Celgi_1822	2.6e-55	177.0	2E37T@1|root,32Y7G@2|Bacteria,2GQH5@201174|Actinobacteria,4F2VR@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
k59_1377650_1	84751.XP_007875969.1	2.28e-36	142.0	COG1874@1|root,2RYV5@2759|Eukaryota,39YNT@33154|Opisthokonta,3P1J1@4751|Fungi,3VB0C@5204|Basidiomycota,3N42D@452284|Ustilaginomycotina	4751|Fungi	O	Beta-galactosidase trimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_42,Glyco_hydro_42M
k59_1862660_2	795666.MW7_3293	1.74e-09	58.9	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2VHZN@28216|Betaproteobacteria,1K26U@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_674081_1	367299.JOEE01000008_gene438	1.28e-72	232.0	COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4FEVM@85021|Intrasporangiaceae	201174|Actinobacteria	M	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase,HTH_3
k59_394650_1	1380354.JIAN01000008_gene3482	1.65e-69	218.0	COG4122@1|root,COG4122@2|Bacteria,2GPEV@201174|Actinobacteria,4F10C@85016|Cellulomonadaceae	201174|Actinobacteria	S	O-methyltransferase	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Methyltransf_24,Methyltransf_3
k59_497551_1	589873.EP13_11285	5.79e-57	185.0	COG3132@1|root,COG3132@2|Bacteria,1RA13@1224|Proteobacteria,1RQUQ@1236|Gammaproteobacteria,466XE@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Belongs to the UPF0502 family	yceH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480
k59_732618_1	1298867.AUES01000051_gene4504	4.99e-129	385.0	COG0653@1|root,COG0653@2|Bacteria,1MX0P@1224|Proteobacteria,2U086@28211|Alphaproteobacteria,3K2HA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	U	SecA preprotein cross-linking domain	-	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SecA_DEAD,SecA_PP_bind
k59_1862666_1	768671.ThimaDRAFT_0195	7.2e-77	245.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WXFD@135613|Chromatiales	135613|Chromatiales	P	PFAM Cation	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_988067_1	439235.Dalk_4509	3.81e-46	162.0	COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,434AT@68525|delta/epsilon subdivisions,2X9GM@28221|Deltaproteobacteria,2MNQ4@213118|Desulfobacterales	28221|Deltaproteobacteria	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_1271804_1	477641.MODMU_2716	2.03e-37	144.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4ERWA@85013|Frankiales	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	-	ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.23	-	-	E1-E2_ATPase,Hydrolase
k59_988068_1	205914.HS_1708	8.27e-92	292.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1Y7TQ@135625|Pasteurellales	135625|Pasteurellales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_736397_1	1163617.SCD_n00183	2.18e-90	276.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_442330_1	1515746.HR45_06835	3.81e-23	100.0	COG0754@1|root,COG0754@2|Bacteria,1MW6V@1224|Proteobacteria,1RQAP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Glutathionylspermidine synthase	gsp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008884,GO:0008885,GO:0016787,GO:0016810,GO:0016811,GO:0016874,GO:0016879,GO:0016880,GO:0044424,GO:0044444,GO:0044464	3.5.1.78,6.3.1.8	ko:K01460	ko00480,ko01100,map00480,map01100	-	R01917,R01918	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	iECIAI39_1322.ECIAI39_3484	CHAP,GSP_synth
k59_677762_1	1163617.SCD_n01356	6.69e-33	124.0	COG1638@1|root,COG1638@2|Bacteria,1PN6J@1224|Proteobacteria,2VSNQ@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_677762_2	1163617.SCD_n01357	2.36e-31	119.0	COG5660@1|root,32WII@2|Bacteria,1R3ME@1224|Proteobacteria	1224|Proteobacteria	S	TRAP transporter T-component	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
k59_789640_1	1122963.AUHB01000014_gene4238	0.000497	42.7	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,36XUM@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	MA20_18095	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_789640_2	1408473.JHXO01000003_gene2549	5.19e-45	156.0	29HWC@1|root,304TF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
k59_49257_1	95619.PM1_0209850	8.38e-147	437.0	COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,1RMSM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
k59_49258_1	228405.HNE_1835	6.1e-09	58.9	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,43X1D@69657|Hyphomonadaceae	28211|Alphaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
k59_736410_1	643648.Slip_1404	9.86e-25	94.7	COG2442@1|root,COG2442@2|Bacteria,1VYG9@1239|Firmicutes,252G4@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
k59_1868552_2	1049564.TevJSym_ac00070	1.27e-146	421.0	COG0348@1|root,COG0348@2|Bacteria,1MWR5@1224|Proteobacteria,1SJST@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
k59_1340331_1	1122933.JNIY01000003_gene979	9.03e-103	323.0	COG0525@1|root,COG0525@2|Bacteria,2GK8H@201174|Actinobacteria,4F0W1@85016|Cellulomonadaceae	201174|Actinobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_1271829_1	1385520.N802_08855	3.38e-25	103.0	COG1249@1|root,COG1249@2|Bacteria,2GNSR@201174|Actinobacteria,4FFPD@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	mtr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0010126,GO:0016137,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050627,GO:0050660,GO:0050661,GO:0050662,GO:0051186,GO:0055114,GO:0070402,GO:0071704,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901657	1.8.1.15	ko:K17883	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_1271829_2	1385519.N801_04835	7.38e-51	169.0	COG3185@1|root,COG3185@2|Bacteria,2GIYF@201174|Actinobacteria,4FJZE@85021|Intrasporangiaceae	201174|Actinobacteria	E	4-Hydroxyphenylpyruvate dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_400560_1	1206731.BAGB01000170_gene4518	2.39e-64	207.0	COG1304@1|root,COG1304@2|Bacteria,2GJA5@201174|Actinobacteria,4FU09@85025|Nocardiaceae	201174|Actinobacteria	C	FMN-dependent dehydrogenase	-	-	1.1.2.3,1.1.3.15	ko:K00101,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00196,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FMN_dh
k59_400560_2	1033806.HTIA_1835	8.62e-07	50.8	COG1402@1|root,arCOG04536@2157|Archaea,2XTQE@28890|Euryarchaeota,23S9I@183963|Halobacteria	183963|Halobacteria	H	Creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
k59_49270_1	1121396.KB893061_gene2688	1.59e-10	67.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,42N91@68525|delta/epsilon subdivisions,2WIMM@28221|Deltaproteobacteria,2MIKE@213118|Desulfobacterales	28221|Deltaproteobacteria	J	RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
k59_618242_1	1283300.ATXB01000001_gene971	2.19e-16	77.4	COG1442@1|root,COG1442@2|Bacteria,1R5NA@1224|Proteobacteria,1SJX1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_618242_2	1288298.rosmuc_01637	1.43e-100	305.0	2DG8R@1|root,2ZUYV@2|Bacteria,1RG4Q@1224|Proteobacteria,2U6V3@28211|Alphaproteobacteria,46PSZ@74030|Roseovarius	28211|Alphaproteobacteria	H	Sulfotransferase family	-	-	2.8.2.2	ko:K01015	ko00140,map00140	-	R00629,R03405,R08977,R08978	RC00007,RC00231,RC00341	ko00000,ko00001,ko01000	-	-	-	Sulfotransfer_1
k59_559604_1	395961.Cyan7425_2666	2.43e-29	115.0	2DBFF@1|root,2Z8YA@2|Bacteria,1G2KB@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_4,HTH_Tnp_4
k59_988115_1	667014.Thein_0694	2.59e-74	235.0	COG1186@1|root,COG1186@2|Bacteria,2GGX5@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_282015_1	335543.Sfum_3755	2.84e-55	189.0	COG5421@1|root,COG5421@2|Bacteria,1Q09R@1224|Proteobacteria,437PJ@68525|delta/epsilon subdivisions,2WYMZ@28221|Deltaproteobacteria,2MRCG@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_501045_1	177437.HRM2_09390	2e-71	234.0	COG5421@1|root,COG5421@2|Bacteria,1R25F@1224|Proteobacteria,433HE@68525|delta/epsilon subdivisions,2WYHG@28221|Deltaproteobacteria,2MP7M@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Domain of unknown function (DUF4277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4277
k59_1615394_1	1117379.BABA_01180	1.51e-23	101.0	COG1131@1|root,COG1131@2|Bacteria,1TRNT@1239|Firmicutes,4HB3P@91061|Bacilli,1ZCY2@1386|Bacillus	91061|Bacilli	V	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1506967_1	414684.RC1_2764	1.68e-88	286.0	COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2JPV8@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1042 Acyl-CoA synthetase (NDP forming)	yfiQ	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_1143769_1	1122212.AULO01000011_gene357	3.93e-49	176.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1XHR3@135619|Oceanospirillales	135619|Oceanospirillales	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
k59_1025065_1	95619.PM1_0229030	1.72e-28	114.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_1025065_2	1300345.LF41_3149	4.08e-50	169.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,1X4ZH@135614|Xanthomonadales	135614|Xanthomonadales	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
k59_1025065_3	626887.J057_08316	4.3e-41	143.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,464DZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	COG1192 ATPases involved in chromosome partitioning	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_790150_2	768671.ThimaDRAFT_0336	1.92e-66	207.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1WWVI@135613|Chromatiales	135613|Chromatiales	K	PFAM Cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
k59_989243_1	977880.RALTA_A1940	4.45e-49	158.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2VSHX@28216|Betaproteobacteria,1K7US@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_442974_1	340177.Cag_0616	1.55e-11	72.4	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Big_3_2,CHU_C,Flg_new,LRR_5
k59_1557773_2	446469.Sked_20630	3.52e-172	488.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_1557773_3	1246995.AFR_10410	9.92e-31	114.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4D9QU@85008|Micromonosporales	201174|Actinobacteria	E	COG0410 ABC-type branched-chain amino acid transport systems, ATPase component	livF	-	-	ko:K01995,ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_1025078_1	1038869.AXAN01000020_gene4144	2.22e-96	304.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VM2H@28216|Betaproteobacteria,1K0UN@119060|Burkholderiaceae	28216|Betaproteobacteria	L	helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_401704_1	1035308.AQYY01000001_gene2351	3.13e-80	262.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,260JQ@186807|Peptococcaceae	186801|Clostridia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1616022_1	37919.EP51_27685	8.5e-25	103.0	COG1309@1|root,COG1309@2|Bacteria,2HD07@201174|Actinobacteria,4FWEB@85025|Nocardiaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_108201_1	765911.Thivi_1735	1.38e-109	330.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1WWCI@135613|Chromatiales	135613|Chromatiales	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_1272610_1	400682.PAC_15711221	8.87e-60	200.0	COG0316@1|root,KOG1120@2759|Eukaryota,3A9KT@33154|Opisthokonta,3BV66@33208|Metazoa	33208|Metazoa	P	Iron-sulphur cluster biosynthesis	-	-	-	ko:K22063	-	-	-	-	ko00000,ko03029	-	-	-	Fe-S_biosyn
k59_678491_1	545276.KB898727_gene453	2.87e-84	276.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales	135613|Chromatiales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_854056_1	1121116.KB894765_gene762	2.3e-76	240.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VH43@28216|Betaproteobacteria,4A9UK@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_1206856_1	886293.Sinac_2401	1.42e-38	143.0	COG0500@1|root,COG4797@1|root,COG0500@2|Bacteria,COG4797@2|Bacteria,2IX32@203682|Planctomycetes	203682|Planctomycetes	Q	Predicted methyltransferase regulatory domain	-	-	-	-	-	-	-	-	-	-	-	-	MethyTransf_Reg,Methyltransf_25,Methyltransf_31
k59_1676998_1	1125863.JAFN01000001_gene2497	7.21e-60	201.0	COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,42NB3@68525|delta/epsilon subdivisions,2X5VB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	TIGRFAM diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_1734256_1	161156.JQKW01000006_gene1055	5.74e-80	245.0	COG0024@1|root,COG0024@2|Bacteria,2GH34@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_108227_1	880072.Desac_0001	5.34e-60	201.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,42MA0@68525|delta/epsilon subdivisions,2WJAT@28221|Deltaproteobacteria,2MR3D@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_1869752_1	1125863.JAFN01000001_gene94	8.44e-160	455.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2WIYB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_1025089_1	1187851.A33M_0476	1.22e-27	108.0	COG0861@1|root,COG0861@2|Bacteria,1PN8B@1224|Proteobacteria,2TUV5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	membrane protein TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
k59_854067_1	1122622.ATWJ01000010_gene1297	1.38e-42	149.0	COG0142@1|root,COG0142@2|Bacteria,2GN1P@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_854067_2	1121924.ATWH01000003_gene1486	3.42e-42	154.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria,4FN2F@85023|Microbacteriaceae	201174|Actinobacteria	O	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_737150_1	583355.Caka_2045	4e-64	228.0	COG0771@1|root,COG2911@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	murD	-	3.4.21.10,6.3.2.13,6.3.2.9	ko:K01317,ko:K01925,ko:K01928,ko:K01932	ko00300,ko00471,ko00550,ko01100,map00300,map00471,map00550,map01100	-	R02783,R02788	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01002,ko01011,ko04131	-	-	-	DUF1727,Mur_ligase_C,Mur_ligase_M
k59_325918_1	768671.ThimaDRAFT_2545	1.2e-25	103.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1WWZW@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
k59_325918_2	1232683.ADIMK_0783	5.38e-28	107.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria,467A5@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
k59_618882_1	768671.ThimaDRAFT_1692	4.03e-101	304.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,1T1GA@1236|Gammaproteobacteria,1WWQR@135613|Chromatiales	135613|Chromatiales	E	PFAM Cys Met metabolism	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_443016_1	446462.Amir_1764	6.04e-15	77.0	COG1073@1|root,COG1073@2|Bacteria,2I3SS@201174|Actinobacteria	201174|Actinobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_443016_2	751944.HALDL1_14690	9.96e-31	115.0	COG2258@1|root,arCOG11383@2157|Archaea,2XXK8@28890|Euryarchaeota,23VKF@183963|Halobacteria	183963|Halobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
k59_443016_3	517417.Cpar_1606	7.41e-23	92.8	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	ylbE	-	1.3.1.75	ko:K19073	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06272,R06896	RC01376	ko00000,ko00001,ko01000	-	-	-	CIA30,NAD_binding_10
k59_560261_1	1125725.HMPREF1325_2235	2.6e-66	220.0	COG0488@1|root,COG0488@2|Bacteria,2J5VJ@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG0488 ATPase components of ABC transporter with duplicated ATPase domains	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
k59_1025109_1	1386089.N865_19290	1.41e-65	207.0	COG2227@1|root,COG2227@2|Bacteria,2IIE2@201174|Actinobacteria,4FIIB@85021|Intrasporangiaceae	201174|Actinobacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.11	ko:K03428	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R04237	RC00003,RC00460	ko00000,ko00001,ko01000	-	-	-	Methyltransf_11,Methyltransf_25
k59_678537_1	439235.Dalk_3247	9.45e-76	234.0	COG0727@1|root,COG0727@2|Bacteria,1Q0JM@1224|Proteobacteria,42N6S@68525|delta/epsilon subdivisions,2WMTR@28221|Deltaproteobacteria,2MIXY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_1869800_1	1121899.Q764_00465	2.77e-45	156.0	COG1878@1|root,COG1878@2|Bacteria,4NFYB@976|Bacteroidetes,1IIVK@117743|Flavobacteriia,2P0GH@237|Flavobacterium	976|Bacteroidetes	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
k59_678541_1	1122921.KB898199_gene2880	1.53e-16	84.3	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,1TPYV@1239|Firmicutes,4HAB5@91061|Bacilli,26QGM@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine	yitJ	-	1.5.1.20,2.1.1.10,2.1.1.5	ko:K00297,ko:K00544,ko:K00547	ko00260,ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00260,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R02821,R07168	RC00003,RC00035,RC00081,RC00496	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
k59_1143828_1	582899.Hden_3206	1.51e-139	414.0	COG0791@1|root,COG0791@2|Bacteria,1MU8A@1224|Proteobacteria,2U1XU@28211|Alphaproteobacteria,3N8B1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	NLP P60 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_150229_2	713587.THITH_03495	2.9e-77	246.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RQ11@1236|Gammaproteobacteria,1WX9G@135613|Chromatiales	135613|Chromatiales	C	PFAM Malic enzyme, NAD binding domain	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
k59_989344_1	765912.Thimo_2365	5.58e-146	445.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales	135613|Chromatiales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_50496_1	485913.Krac_12534	5.17e-82	272.0	COG0086@1|root,COG0086@2|Bacteria,2G632@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1734302_1	446466.Cfla_1901	8.57e-123	361.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,2GMFH@201174|Actinobacteria	201174|Actinobacteria	E	PHP domain	polX	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	HHH_8,PHP
k59_443037_1	1121405.dsmv_1436	7.45e-168	483.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,42MKE@68525|delta/epsilon subdivisions,2WJF1@28221|Deltaproteobacteria,2MJ0Z@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_1616088_1	935839.JAGJ01000007_gene3101	7.96e-163	472.0	COG0606@1|root,COG0606@2|Bacteria,2GJIQ@201174|Actinobacteria,4F38C@85017|Promicromonosporaceae	201174|Actinobacteria	O	Magnesium chelatase, subunit ChlI C-terminal	comM	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_1616088_2	446466.Cfla_1480	6.02e-20	91.7	COG0758@1|root,COG0758@2|Bacteria,2GKDA@201174|Actinobacteria,4F0K2@85016|Cellulomonadaceae	201174|Actinobacteria	LU	DNA recombination-mediator protein A	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_325955_1	880072.Desac_2391	1.78e-46	166.0	COG0480@1|root,COG0480@2|Bacteria,1R0V4@1224|Proteobacteria,42M1F@68525|delta/epsilon subdivisions,2WIYM@28221|Deltaproteobacteria,2MR6X@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Elongation factor Tu domain 2	fusA-1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1511987_3	882082.SaccyDRAFT_4363	2.34e-20	91.7	COG0642@1|root,COG2205@2|Bacteria,2GM17@201174|Actinobacteria,4E0HJ@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase	mprB	GO:0000160,GO:0003674,GO:0003824,GO:0004721,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023052,GO:0035556,GO:0036211,GO:0040007,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07653	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_565088_1	313596.RB2501_02230	1.93e-89	277.0	COG0624@1|root,COG0624@2|Bacteria,4NEA7@976|Bacteroidetes,1HYG1@117743|Flavobacteriia	976|Bacteroidetes	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_1387057_2	1165096.ARWF01000001_gene2027	2.29e-61	199.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,2KKH8@206350|Nitrosomonadales	206350|Nitrosomonadales	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_565343_1	1318628.MARLIPOL_07114	2.32e-116	349.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,4658N@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0031224,GO:0031226,GO:0034641,GO:0036094,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	iEcE24377_1341.EcE24377A_1810	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
k59_623931_1	1122599.AUGR01000024_gene1390	5.3e-09	56.6	COG1396@1|root,COG1396@2|Bacteria,1R4NU@1224|Proteobacteria,1RQG0@1236|Gammaproteobacteria,1XPT2@135619|Oceanospirillales	135619|Oceanospirillales	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
k59_1621026_1	1205680.CAKO01000002_gene3078	2.45e-113	335.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MURA@1224|Proteobacteria,2TR1F@28211|Alphaproteobacteria,2JPND@204441|Rhodospirillales	204441|Rhodospirillales	P	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_1211560_1	323261.Noc_1414	6.23e-80	243.0	COG1458@1|root,COG1458@2|Bacteria,1RGR2@1224|Proteobacteria,1S4IR@1236|Gammaproteobacteria,1X0N5@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0278 family	-	-	-	ko:K09006	-	-	-	-	ko00000	-	-	-	PIN_5
k59_683686_1	187272.Mlg_2638	1.8e-17	82.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,1WVUX@135613|Chromatiales	135613|Chromatiales	M	Lipid A biosynthesis	lpxL	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_683686_2	1158756.AQXQ01000012_gene1847	3.66e-51	176.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1WWQB@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
k59_1739469_1	215803.DB30_4155	5.29e-89	272.0	COG0604@1|root,COG0604@2|Bacteria,1QY04@1224|Proteobacteria,43AHJ@68525|delta/epsilon subdivisions,2X5XS@28221|Deltaproteobacteria,2YUNY@29|Myxococcales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
k59_1348900_1	768706.Desor_2211	1e-30	119.0	COG4974@1|root,COG4974@2|Bacteria,1TR57@1239|Firmicutes,24ACW@186801|Clostridia,26128@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_1739472_1	713586.KB900536_gene2613	3.03e-76	248.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales	135613|Chromatiales	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_1148353_1	1121405.dsmv_2036	7.89e-33	124.0	COG0224@1|root,COG0224@2|Bacteria,1N4GR@1224|Proteobacteria,42S5M@68525|delta/epsilon subdivisions,2WNX2@28221|Deltaproteobacteria,2MNHY@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Gamma subunit	-	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_858795_1	290398.Csal_2344	2.01e-79	259.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1XHWN@135619|Oceanospirillales	135619|Oceanospirillales	J	due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_56888_1	985255.APHJ01000021_gene1435	2.76e-61	201.0	COG1960@1|root,COG1960@2|Bacteria,4NEKJ@976|Bacteroidetes,1HYD3@117743|Flavobacteriia,2P655@244698|Gillisia	976|Bacteroidetes	I	Acyl-CoA dehydrogenase, N-terminal domain	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_213763_1	998088.B565_1391	3.67e-71	225.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria,1Y4HV@135624|Aeromonadales	135624|Aeromonadales	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
k59_1387083_1	33876.JNXY01000020_gene4476	1.12e-16	83.2	COG0671@1|root,COG0671@2|Bacteria,2HIXE@201174|Actinobacteria,4DB5P@85008|Micromonosporales	201174|Actinobacteria	I	Phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
k59_409100_1	1283284.AZUK01000001_gene812	6.86e-103	303.0	COG2249@1|root,COG2249@2|Bacteria,1MUHN@1224|Proteobacteria,1RU3S@1236|Gammaproteobacteria,1Y501@135624|Aeromonadales	135624|Aeromonadales	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_2
k59_858800_1	1007105.PT7_0100	4.82e-124	383.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,3T1KP@506|Alcaligenaceae	28216|Betaproteobacteria	F	Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_1211580_1	706587.Desti_2472	1.79e-46	151.0	COG4802@1|root,COG4802@2|Bacteria,1RI70@1224|Proteobacteria,42SXJ@68525|delta/epsilon subdivisions,2WP19@28221|Deltaproteobacteria,2MS00@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
k59_1211580_2	1121405.dsmv_3379	4.54e-40	134.0	COG0695@1|root,COG0695@2|Bacteria,1NAZM@1224|Proteobacteria,42VIA@68525|delta/epsilon subdivisions,2WR8X@28221|Deltaproteobacteria,2MKPI@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM Glutaredoxin	-	-	-	ko:K06191	-	-	-	-	ko00000	-	-	-	Glutaredoxin
k59_937168_1	743836.AYNA01000035_gene674	9.2e-29	121.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,36XJ1@31993|Methylocystaceae	28211|Alphaproteobacteria	L	PD-(D/E)XK nuclease superfamily	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
k59_1621055_1	1101192.KB910516_gene2971	1.89e-97	311.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2TVZI@28211|Alphaproteobacteria,1JSN8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_289589_1	1217720.ALOX01000001_gene3378	4.26e-45	161.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria,2JQCU@204441|Rhodospirillales	204441|Rhodospirillales	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
k59_937176_1	983917.RGE_20810	2.08e-27	108.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,2VQVG@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Methyltransferase type 11	arsM	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
k59_683712_1	471853.Bcav_1916	8.1e-110	343.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,2GJ11@201174|Actinobacteria	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
k59_1446797_1	991905.SL003B_0362	2.14e-70	221.0	COG0697@1|root,COG0697@2|Bacteria,1R4G2@1224|Proteobacteria,2TTS7@28211|Alphaproteobacteria,4BQMJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_115573_1	401053.AciPR4_1402	6.08e-42	156.0	COG0018@1|root,COG0018@2|Bacteria,3Y35R@57723|Acidobacteria,2JIAM@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_996464_1	1035308.AQYY01000001_gene2578	1.33e-56	194.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia,260BN@186807|Peptococcaceae	186801|Clostridia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_1348950_1	1094491.BBbe_13250	5.41e-13	73.9	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2TSTN@28211|Alphaproteobacteria,48TJ9@772|Bartonellaceae	28211|Alphaproteobacteria	K	ParB-like nuclease domain	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_794217_2	471853.Bcav_0621	2.14e-38	137.0	COG4965@1|root,COG4965@2|Bacteria,2I6JB@201174|Actinobacteria	201174|Actinobacteria	U	Type II secretion system (T2SS), protein F	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
k59_794217_3	471853.Bcav_0620	7.89e-31	116.0	COG4965@1|root,COG4965@2|Bacteria	2|Bacteria	U	Type ii secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	-
k59_683721_1	2340.JV46_06490	5.22e-63	204.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1J4F3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_937191_1	1304865.JAGF01000001_gene3215	3.89e-46	152.0	COG4768@1|root,COG4768@2|Bacteria,2II1J@201174|Actinobacteria,4F1BU@85016|Cellulomonadaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF948)	-	-	-	-	-	-	-	-	-	-	-	-	DUF948
k59_1387101_1	1121405.dsmv_1445	2.56e-106	323.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2MI6Q@213118|Desulfobacterales	28221|Deltaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_565386_1	1255043.TVNIR_1329	5.46e-269	762.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,1WW7D@135613|Chromatiales	135613|Chromatiales	C	Molybdopterin oxidoreductase Fe4S4 domain	napA	-	-	ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_937202_1	472759.Nhal_2673	1.86e-143	439.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon
k59_115595_1	926564.KI911656_gene1548	3.47e-89	291.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2GN09@201174|Actinobacteria,4F3YP@85017|Promicromonosporaceae	201174|Actinobacteria	E	GXGXG motif	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_56933_1	756272.Plabr_1290	1.62e-16	82.4	COG1045@1|root,COG1045@2|Bacteria,2IX5K@203682|Planctomycetes	203682|Planctomycetes	E	COG1045 Serine acetyltransferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep
k59_858827_1	522306.CAP2UW1_1312	2.09e-23	104.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VI6T@28216|Betaproteobacteria,1KQH5@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4
k59_1562919_1	1297742.A176_00261	3.86e-06	53.9	COG2885@1|root,COG2885@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,DUF11,OmpA,Phenol_MetA_deg,TSP_3
k59_1621090_2	1121447.JONL01000004_gene2762	2.02e-34	122.0	2E57Z@1|root,3300G@2|Bacteria,1NBSS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1148401_2	880072.Desac_2700	2.35e-58	196.0	COG1488@1|root,COG1488@2|Bacteria,1R5W0@1224|Proteobacteria,42NQQ@68525|delta/epsilon subdivisions,2WJ4V@28221|Deltaproteobacteria,2MQV1@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C
k59_1877234_1	156889.Mmc1_2196	1.14e-11	70.9	COG2931@1|root,COG3210@1|root,COG3827@1|root,COG4447@1|root,COG4625@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3827@2|Bacteria,COG4447@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4347,He_PIG,HemolysinCabind,VWA_2
k59_409174_1	935840.JAEQ01000014_gene4056	2.5e-76	241.0	COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,2TR0E@28211|Alphaproteobacteria,43I18@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	phospho-2-dehydro-3-deoxyheptonate aldolase	aroF	GO:0003674,GO:0003824,GO:0003849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009507,GO:0009536,GO:0009611,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0050896,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
k59_1030744_2	395493.BegalDRAFT_2598	1.35e-45	152.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,1S3QK@1236|Gammaproteobacteria,460U0@72273|Thiotrichales	72273|Thiotrichales	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
k59_996513_1	768671.ThimaDRAFT_0705	1.12e-101	314.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_1877245_1	349106.PsycPRwf_1087	8.01e-15	79.3	COG2304@1|root,COG2373@1|root,COG2911@1|root,COG2931@1|root,COG4932@1|root,COG2304@2|Bacteria,COG2373@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,3NKB9@468|Moraxellaceae	1236|Gammaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	ko:K11005	-	-	-	-	ko00000,ko02000,ko02042	1.C.11	-	-	Big_3_2,Cadherin_3,Calx-beta,HCBP_related,He_PIG,HemolysinCabind,OmpA_membrane,RTX,RTX_C,VWA_2,fn3
k59_1621098_1	1306406.ASHX01000001_gene1864	1.03e-22	93.6	COG1993@1|root,COG1993@2|Bacteria,2IM7J@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
k59_1621098_2	999419.HMPREF1077_00389	2.1e-12	66.6	COG0205@1|root,COG0205@2|Bacteria,4NF8F@976|Bacteroidetes,2FMPI@200643|Bacteroidia,22W6D@171551|Porphyromonadaceae	976|Bacteroidetes	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
k59_409181_2	1163407.UU7_01232	9.52e-19	81.3	COG1555@1|root,COG1555@2|Bacteria,1N6Q3@1224|Proteobacteria,1SC7U@1236|Gammaproteobacteria,1X84H@135614|Xanthomonadales	135614|Xanthomonadales	L	competence protein ComEA	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3
k59_683750_1	985867.AEWF01000003_gene983	1.92e-65	224.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,47G2C@766|Rickettsiales	766|Rickettsiales	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	POR,TPP_enzyme_C
k59_858839_1	1267005.KB911255_gene2507	3.07e-102	305.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2TQSV@28211|Alphaproteobacteria,3N6BP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_683752_1	1121019.AUMN01000001_gene719	1.27e-52	185.0	COG0699@1|root,COG0699@2|Bacteria,2GJX9@201174|Actinobacteria,1W8MB@1268|Micrococcaceae	201174|Actinobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_937247_1	314278.NB231_10924	1.84e-42	152.0	COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,1RN5P@1236|Gammaproteobacteria,1WYPF@135613|Chromatiales	135613|Chromatiales	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	AAA_23,SMC_N
k59_1387137_1	375286.mma_2897	1.3e-30	115.0	COG2980@1|root,COG2980@2|Bacteria,1N13K@1224|Proteobacteria,2VU54@28216|Betaproteobacteria,474IZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane	lptE	-	-	ko:K03643	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptE
k59_213821_2	546274.EIKCOROL_00310	0.000189	43.1	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2VH5M@28216|Betaproteobacteria,2KPRQ@206351|Neisseriales	206351|Neisseriales	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_409198_1	765911.Thivi_2465	1.56e-109	333.0	COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria,1WWX3@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	2.7.13.3	ko:K07673	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3
k59_155520_1	1713.JOFV01000005_gene2383	2.75e-21	98.2	COG5278@1|root,COG5278@2|Bacteria,2GJ1Q@201174|Actinobacteria,4F1BR@85016|Cellulomonadaceae	201174|Actinobacteria	T	phosphoserine phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1387149_1	1112204.GPOL_c41030	1.74e-24	102.0	COG1020@1|root,COG1020@2|Bacteria,2GKU0@201174|Actinobacteria,4GD5R@85026|Gordoniaceae	201174|Actinobacteria	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
k59_331290_2	1232683.ADIMK_0681	1.46e-64	211.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,4641I@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	Glutaredoxin,PALP
k59_624031_2	935863.AWZR01000001_gene1573	1.47e-24	102.0	COG1668@1|root,COG1668@2|Bacteria,1R3RG@1224|Proteobacteria,1T04X@1236|Gammaproteobacteria,1XCYU@135614|Xanthomonadales	135614|Xanthomonadales	CP	Sodium ABC transporter permease	-	-	-	ko:K09696	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.115	-	-	ABC2_membrane_2,ABC2_membrane_3
k59_448202_1	1396141.BATP01000001_gene5330	1.79e-77	250.0	28HMZ@1|root,2Z7WD@2|Bacteria,46TFX@74201|Verrucomicrobia,2IVCD@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_1562953_1	935839.JAGJ01000005_gene2667	3.2e-63	209.0	28MY8@1|root,2ZB54@2|Bacteria,2GMYY@201174|Actinobacteria,4F53A@85017|Promicromonosporaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_213839_1	349521.HCH_03020	1.12e-73	246.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1XHSN@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_565440_1	1379281.AVAG01000032_gene119	2.92e-74	237.0	COG0438@1|root,COG0438@2|Bacteria,1R8YI@1224|Proteobacteria,42N8I@68525|delta/epsilon subdivisions,2WIYJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
k59_937281_1	1121439.dsat_1401	6.39e-92	273.0	COG0243@1|root,COG0243@2|Bacteria,1MWPS@1224|Proteobacteria,42QIW@68525|delta/epsilon subdivisions,2WJPY@28221|Deltaproteobacteria,2MB0B@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	molybdopterin oxidoreductase Fe4S4	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,TAT_signal
k59_1621132_1	1122176.KB903553_gene3640	4.46e-53	183.0	COG0477@1|root,COG2814@2|Bacteria,4NE09@976|Bacteroidetes,1IP67@117747|Sphingobacteriia	976|Bacteroidetes	EGP	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
k59_331304_1	42256.RradSPS_2486	3.95e-44	163.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria,4CPCB@84995|Rubrobacteria	84995|Rubrobacteria	EQ	Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k59_289668_1	1301098.PKB_3055	8.96e-62	190.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,Cupin_3,Cupin_7,Globin
k59_289668_2	686340.Metal_0787	4.21e-29	108.0	COG1853@1|root,COG1853@2|Bacteria,1NB1B@1224|Proteobacteria,1S55P@1236|Gammaproteobacteria,1XG9Z@135618|Methylococcales	135618|Methylococcales	S	PFAM Flavin	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
k59_409234_1	1440774.Y900_002460	1.48e-35	128.0	COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,233KN@1762|Mycobacteriaceae	201174|Actinobacteria	G	catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor	ppgK	GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0040007,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0047330,GO:0051156,GO:0071704,GO:1901135	2.7.1.2,2.7.1.63	ko:K00845,ko:K00886	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786,R02187,R02189	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_409234_2	1136138.JH604622_gene1307	1.69e-11	68.6	COG0402@1|root,COG0402@2|Bacteria,1MUPT@1224|Proteobacteria,1SYCI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Guanine deaminase	guaD	-	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_1446877_2	395493.BegalDRAFT_1514	3.15e-19	80.5	COG5481@1|root,COG5481@2|Bacteria	2|Bacteria	S	small protein containing a coiled-coil domain	MA20_03740	-	-	-	-	-	-	-	-	-	-	-	DUF465
k59_331314_1	367299.JOEE01000002_gene2447	8.8e-111	329.0	COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,4FFPC@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_742456_1	349124.Hhal_0463	1.43e-88	288.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,1WW62@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_858881_1	1123255.JHYS01000009_gene2260	5.28e-99	299.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria,4A9UW@80864|Comamonadaceae	28216|Betaproteobacteria	G	TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM
k59_1349073_1	84531.JMTZ01000045_gene1015	5.11e-30	122.0	COG1305@1|root,COG1305@2|Bacteria,1R5BE@1224|Proteobacteria,1SYRA@1236|Gammaproteobacteria,1XCSR@135614|Xanthomonadales	135614|Xanthomonadales	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,Transglut_core
k59_1682842_2	1121405.dsmv_0072	2.47e-25	106.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,42N18@68525|delta/epsilon subdivisions,2WJSK@28221|Deltaproteobacteria,2MIUA@213118|Desulfobacterales	28221|Deltaproteobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	sucB	-	2.3.1.12,2.3.1.61	ko:K00627,ko:K00658	ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00307	R00209,R02569,R02570,R02571,R08549	RC00004,RC02727,RC02742,RC02833,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2766	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_1212630_1	396595.TK90_2191	5.58e-63	215.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_332297_1	1121921.KB898707_gene1010	1.49e-47	169.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,2PN4F@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	L	DHH family	recJ	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_867170_2	1049564.TevJSym_ag00300	1.96e-47	169.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1J56B@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_17,Fer4_7,Fer4_8
k59_1039113_1	880072.Desac_1559	9.55e-107	323.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42QFH@68525|delta/epsilon subdivisions,2WKWR@28221|Deltaproteobacteria,2MREA@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	hpnJ	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_572646_1	1320556.AVBP01000001_gene4175	1.36e-85	267.0	COG0477@1|root,2Z82B@2|Bacteria,1R9GD@1224|Proteobacteria,2TTIS@28211|Alphaproteobacteria,43J6X@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_799961_1	1232683.ADIMK_0630	7.63e-42	155.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,4668G@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	ycbB	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
k59_221128_1	686578.AFFX01000011_gene2510	5.75e-09	55.5	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
k59_221128_2	383407.XOC_3660	6.88e-35	132.0	COG0006@1|root,COG0006@2|Bacteria,1MURT@1224|Proteobacteria,1RMKT@1236|Gammaproteobacteria,1X3Z6@135614|Xanthomonadales	135614|Xanthomonadales	E	Splits dipeptides with a prolyl residue in the C- terminal position	pepQ	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_1570678_1	373903.Hore_07740	3.48e-29	117.0	COG0750@1|root,COG0750@2|Bacteria,1TPMC@1239|Firmicutes,247MT@186801|Clostridia,3WAGW@53433|Halanaerobiales	186801|Clostridia	M	PDZ domain (Also known as DHR or GLGF)	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_1570679_1	994573.T472_0206090	1.07e-15	76.3	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,36DUE@31979|Clostridiaceae	186801|Clostridia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_1570679_2	933262.AXAM01000034_gene1562	1.32e-18	83.2	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,42TMM@68525|delta/epsilon subdivisions,2WQ6S@28221|Deltaproteobacteria,2MKHV@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
k59_1219622_1	756272.Plabr_2416	1.18e-71	229.0	COG1520@1|root,COG1520@2|Bacteria,2IWWY@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
k59_1454955_1	314230.DSM3645_04555	2.83e-50	178.0	COG0443@1|root,COG0443@2|Bacteria,2IWWS@203682|Planctomycetes	203682|Planctomycetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_867194_2	338966.Ppro_0711	6.63e-07	52.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,42MAG@68525|delta/epsilon subdivisions,2WM94@28221|Deltaproteobacteria,43S5I@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Belongs to the TrpC family	trpC	-	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2494	IGPS
k59_799971_1	1049564.TevJSym_ag00450	4e-127	375.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1J5AP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_0417	Anth_synt_I_N,Chorismate_bind
k59_514098_1	1089455.MOPEL_009_00980	1.28e-12	68.2	COG1307@1|root,COG1307@2|Bacteria,2GIUV@201174|Actinobacteria,4F7X6@85018|Dermatophilaceae	201174|Actinobacteria	S	Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
k59_514098_2	408672.NBCG_05344	1.87e-62	213.0	COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,4DNGN@85009|Propionibacteriales	201174|Actinobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1394640_1	1035308.AQYY01000002_gene103	1.77e-27	110.0	COG0446@1|root,COG0446@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,2606T@186807|Peptococcaceae	186801|Clostridia	P	pyridine nucleotide-disulphide oxidoreductase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
k59_1394640_2	1177594.MIC448_940017	1.36e-16	79.7	COG0580@1|root,COG0580@2|Bacteria,2GMG4@201174|Actinobacteria,4FNDY@85023|Microbacteriaceae	201174|Actinobacteria	G	Major intrinsic protein	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	MIP
k59_1570702_1	754476.Q7A_1136	2.55e-49	178.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,4604N@72273|Thiotrichales	72273|Thiotrichales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_339213_1	1211114.ALIP01000146_gene2827	9.56e-39	140.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1X4AP@135614|Xanthomonadales	135614|Xanthomonadales	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
k59_1454978_1	1187851.A33M_1610	4.47e-62	199.0	COG1719@1|root,COG1719@2|Bacteria,1REDE@1224|Proteobacteria,2UA9M@28211|Alphaproteobacteria,3FEDK@34008|Rhodovulum	28211|Alphaproteobacteria	S	V4R	bchJ	GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015994,GO:0015995,GO:0018130,GO:0019438,GO:0030493,GO:0030494,GO:0033013,GO:0033014,GO:0034641,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	ko:K04036	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06271	RC01376	ko00000,ko00001,ko01000	-	-	-	V4R
k59_1219650_2	1968.JOEV01000005_gene6334	9.44e-08	56.2	COG1082@1|root,COG1082@2|Bacteria,2ICQ0@201174|Actinobacteria	201174|Actinobacteria	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_221164_1	1131553.JIBI01000050_gene1003	5.02e-154	453.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2VH5H@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG2	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k59_455424_1	765913.ThidrDRAFT_0731	6.76e-31	112.0	COG0789@1|root,COG0789@2|Bacteria,1N9MT@1224|Proteobacteria,1SE7J@1236|Gammaproteobacteria,1WZDM@135613|Chromatiales	135613|Chromatiales	K	MerR HTH family regulatory protein	-	-	-	ko:K18997	-	-	-	-	ko00000,ko03036	-	-	-	MerR_2
k59_1287443_2	945713.IALB_2046	4.7e-44	160.0	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	agmM	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
k59_1039189_1	522306.CAP2UW1_2978	4.26e-79	244.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_1747369_1	323261.Noc_2259	1.49e-15	73.2	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria,1WY0M@135613|Chromatiales	135613|Chromatiales	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
k59_1747369_2	83406.HDN1F_22400	6.45e-31	110.0	COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,1S8RT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
k59_867233_1	857087.Metme_2625	5.55e-08	54.3	COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,1RPG5@1236|Gammaproteobacteria,1XECA@135618|Methylococcales	135618|Methylococcales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway	nqrF	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
k59_867233_2	1286106.MPL1_01652	8.96e-84	251.0	COG2209@1|root,COG2209@2|Bacteria,1R33S@1224|Proteobacteria,1RMWV@1236|Gammaproteobacteria,4608S@72273|Thiotrichales	72273|Thiotrichales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrE	-	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
k59_1455001_1	385682.AFSL01000008_gene2555	3.65e-29	119.0	COG2211@1|root,COG2211@2|Bacteria,4NE3B@976|Bacteroidetes,2FPMF@200643|Bacteroidia,3XIS3@558415|Marinilabiliaceae	976|Bacteroidetes	G	MFS/sugar transport protein	yicJ_1	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
k59_1039198_1	926550.CLDAP_02950	1.05e-103	309.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_750017_1	658659.HMPREF0983_00977	5.14e-85	261.0	2BVW3@1|root,2Z7TB@2|Bacteria,1U57H@1239|Firmicutes,3VP5S@526524|Erysipelotrichia	526524|Erysipelotrichia	S	5'-nucleotidase	-	-	-	-	-	-	-	-	-	-	-	-	5-nucleotidase
k59_455436_1	697282.Mettu_0336	2.53e-170	494.0	COG1368@1|root,COG1368@2|Bacteria,1RG6W@1224|Proteobacteria,1RY34@1236|Gammaproteobacteria,1XFZX@135618|Methylococcales	135618|Methylococcales	M	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_163019_2	565045.NOR51B_2687	1.93e-05	47.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1J4VV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	recombinase XerD	xerD	GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1112731_1	661367.LLO_1764	6.41e-56	187.0	COG4651@1|root,COG4651@2|Bacteria,1QUQS@1224|Proteobacteria,1T21E@1236|Gammaproteobacteria,1JCA1@118969|Legionellales	118969|Legionellales	P	sodium hydrogen antiporter	kefC_2	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_572708_2	59196.RICGR_0982	1.73e-08	62.0	COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins	zipA	GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0022402,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032506,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047	-	ko:K03528	-	-	-	-	ko00000,ko03036	-	-	-	ZipA_C
k59_1394693_1	44060.JODL01000001_gene3071	1.08e-09	58.5	COG2197@1|root,COG2197@2|Bacteria,2GN3A@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	chiR	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1394693_2	768671.ThimaDRAFT_0197	4.22e-39	149.0	COG0834@1|root,COG4585@1|root,COG0834@2|Bacteria,COG4585@2|Bacteria,1N315@1224|Proteobacteria,1T3XJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
k59_1802146_1	1348657.M622_03955	5.7e-48	165.0	COG0300@1|root,COG0300@2|Bacteria,1R735@1224|Proteobacteria,2VH63@28216|Betaproteobacteria,2KW32@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_631760_1	1454010.JEOE01000015_gene1112	4.36e-80	255.0	COG1207@1|root,COG1207@2|Bacteria,2GJS1@201174|Actinobacteria,4F0YE@85016|Cellulomonadaceae	201174|Actinobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030260,GO:0035635,GO:0040007,GO:0043167,GO:0043169,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
k59_1455027_1	2340.JV46_14330	5.77e-84	270.0	COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_1570769_1	56780.SYN_02213	1.54e-64	218.0	COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1R891@1224|Proteobacteria,42P2C@68525|delta/epsilon subdivisions,2WJZT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
k59_751487_2	1123229.AUBC01000009_gene328	1.68e-15	73.2	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2U99Y@28211|Alphaproteobacteria,3JY5H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
k59_1221028_1	640081.Dsui_3455	5.21e-74	246.0	COG2206@1|root,COG2206@2|Bacteria,1MV37@1224|Proteobacteria,2VJ21@28216|Betaproteobacteria,2KVJ8@206389|Rhodocyclales	206389|Rhodocyclales	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	3.1.4.17	ko:K01120	ko00230,map00230	-	R00191,R01234	RC00296	ko00000,ko00001,ko01000	-	-	-	FHA,GAF,HD,HD_5
k59_1523457_1	272568.GDI2363	3.65e-82	261.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TT6V@28211|Alphaproteobacteria,2JPWF@204441|Rhodospirillales	204441|Rhodospirillales	P	Voltage gated chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
k59_751491_1	367299.JOEE01000009_gene294	1.53e-47	155.0	COG0319@1|root,COG0319@2|Bacteria,2GMUF@201174|Actinobacteria,4FGE2@85021|Intrasporangiaceae	201174|Actinobacteria	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
k59_751491_2	1380354.JIAN01000006_gene907	2.39e-09	61.6	COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4F0HR@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM CBS domain containing protein	corC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_1221032_1	446469.Sked_31860	4.26e-104	309.0	COG0573@1|root,COG0573@2|Bacteria,2GJDA@201174|Actinobacteria	201174|Actinobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_1041096_1	471853.Bcav_1849	1.56e-161	462.0	COG0174@1|root,COG0174@2|Bacteria,2GJ2I@201174|Actinobacteria	201174|Actinobacteria	E	glutamine synthetase	glnA2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_1523464_1	768671.ThimaDRAFT_3386	5.23e-66	213.0	COG0265@1|root,COG3016@1|root,COG0265@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,1RPWZ@1236|Gammaproteobacteria,1WX9T@135613|Chromatiales	135613|Chromatiales	O	smart pdz dhr glgf	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg,PDZ_2
k59_1523464_2	572477.Alvin_0364	7.42e-35	130.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RNPY@1236|Gammaproteobacteria,1WWN2@135613|Chromatiales	135613|Chromatiales	O	PFAM peptidase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
k59_1691358_1	991905.SL003B_4287	1.05e-28	113.0	COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,2TQJD@28211|Alphaproteobacteria,4BPXF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	yejB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0022857,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944	-	ko:K13894	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1
k59_1691358_2	670307.HYPDE_37423	1.67e-25	104.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,3N7Z7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Extracellular solute-binding protein	yejA	-	-	ko:K02035,ko:K13893	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
k59_1572253_1	243233.MCA2784	1.94e-72	231.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1XE1E@135618|Methylococcales	135618|Methylococcales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k59_1396095_1	349124.Hhal_2240	3.7e-124	365.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1WW90@135613|Chromatiales	135613|Chromatiales	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_1396095_2	488538.SAR116_1833	1.73e-14	71.6	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TQKB@28211|Alphaproteobacteria,4BPEB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_1041130_1	765910.MARPU_12605	3.74e-124	381.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales	135613|Chromatiales	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_632938_1	392499.Swit_5197	1.43e-30	121.0	COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2TUGE@28211|Alphaproteobacteria,2K3NU@204457|Sphingomonadales	204457|Sphingomonadales	L	Protein involved in DNA binding and transposition, DNA-mediated	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1156329_1	870187.Thini_2100	7.04e-153	445.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,461JQ@72273|Thiotrichales	72273|Thiotrichales	F	Belongs to the 5'-nucleotidase family	-	-	-	ko:K17224	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	5_nucleotid_C
k59_1041144_1	861299.J421_1499	4e-24	102.0	COG5616@1|root,COG5616@2|Bacteria,1ZTN3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Peptidoglycan-synthase activator LpoB	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
k59_1156331_1	335543.Sfum_1062	1.24e-71	222.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,42N6I@68525|delta/epsilon subdivisions,2WK7S@28221|Deltaproteobacteria,2MQG1@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_632950_1	246437.XP_006153260.1	1.13e-79	260.0	COG1012@1|root,KOG2456@2759|Eukaryota,38CW8@33154|Opisthokonta,3BDR1@33208|Metazoa,3CZ4X@33213|Bilateria,47ZQK@7711|Chordata,497P7@7742|Vertebrata,3J5DC@40674|Mammalia,35F85@314146|Euarchontoglires	33208|Metazoa	C	long-chain-aldehyde dehydrogenase activity	ALDH3A2	GO:0000302,GO:0001561,GO:0003674,GO:0003824,GO:0004028,GO:0004029,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005777,GO:0005778,GO:0005783,GO:0005789,GO:0005829,GO:0006066,GO:0006081,GO:0006082,GO:0006629,GO:0006631,GO:0006643,GO:0006665,GO:0006714,GO:0006720,GO:0006721,GO:0006807,GO:0006950,GO:0006979,GO:0007275,GO:0007399,GO:0007417,GO:0007422,GO:0008150,GO:0008152,GO:0008544,GO:0008610,GO:0009056,GO:0009058,GO:0009062,GO:0009888,GO:0009987,GO:0012505,GO:0016020,GO:0016021,GO:0016042,GO:0016054,GO:0016101,GO:0016491,GO:0016614,GO:0016620,GO:0016899,GO:0016903,GO:0016999,GO:0017144,GO:0019395,GO:0019752,GO:0019898,GO:0030148,GO:0030258,GO:0031090,GO:0031224,GO:0031312,GO:0031903,GO:0031984,GO:0032501,GO:0032502,GO:0032787,GO:0033306,GO:0034308,GO:0034440,GO:0042175,GO:0042221,GO:0042406,GO:0042579,GO:0042802,GO:0042803,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046292,GO:0046395,GO:0046458,GO:0046467,GO:0046577,GO:0046983,GO:0048731,GO:0048856,GO:0050061,GO:0050896,GO:0052814,GO:0055114,GO:0071704,GO:0072329,GO:0098588,GO:0098805,GO:0098827,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901700,GO:1903173	1.2.1.3,1.2.1.5	ko:K00128,ko:K00129,ko:K04513	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00350,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00980,ko00981,ko00982,ko01100,ko01110,ko01120,ko01130,ko04011,ko04014,ko04015,ko04022,ko04024,ko04062,ko04071,ko04072,ko04144,ko04150,ko04270,ko04310,ko04350,ko04360,ko04510,ko04520,ko04530,ko04611,ko04621,ko04660,ko04670,ko04722,ko04810,ko04921,ko04972,ko05100,ko05130,ko05133,ko05152,ko05200,ko05203,ko05204,ko05205,ko05206,ko05210,ko05418,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00350,map00360,map00380,map00410,map00561,map00620,map00625,map00903,map00980,map00981,map00982,map01100,map01110,map01120,map01130,map04011,map04014,map04015,map04022,map04024,map04062,map04071,map04072,map04144,map04150,map04270,map04310,map04350,map04360,map04510,map04520,map04530,map04611,map04621,map04660,map04670,map04722,map04810,map04921,map04972,map05100,map05130,map05133,map05152,map05200,map05203,map05204,map05205,map05206,map05210,map05418	M00135	R00264,R00631,R00710,R00711,R00904,R01752,R01986,R02536,R02537,R02549,R02678,R02695,R02697,R02940,R02957,R03283,R03300,R03302,R03869,R04065,R04506,R04882,R04883,R04888,R04889,R04891,R04892,R04903,R04996,R05050,R05237,R05238,R05286,R06366,R07104,R08146,R08282,R08283,R08307	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500,RC01735	ko00000,ko00001,ko00002,ko01000,ko04031,ko04131,ko04147	-	-	-	Aldedh
k59_573867_1	1499967.BAYZ01000131_gene318	2.62e-126	374.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	MA20_44770	-	-	ko:K02027,ko:K17321	ko02010,map02010	M00207,M00607	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.35	-	-	SBP_bac_1,SBP_bac_8
k59_1748620_1	1120958.AULD01000005_gene2005	1.9e-33	124.0	COG0177@1|root,COG0177@2|Bacteria,2GNE5@201174|Actinobacteria,4FNH3@85023|Microbacteriaceae	201174|Actinobacteria	L	HhH-GPD superfamily base excision DNA repair protein	-	-	-	-	-	-	-	-	-	-	-	-	HhH-GPD
k59_868800_2	933262.AXAM01000052_gene2016	1.45e-75	239.0	COG2199@1|root,COG3706@2|Bacteria,1R8F2@1224|Proteobacteria,42QMA@68525|delta/epsilon subdivisions,2WKC1@28221|Deltaproteobacteria,2MHN4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	DUF484,GGDEF
k59_800995_1	1158146.KB907131_gene1352	3.56e-52	179.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1WW48@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_800995_2	546262.NEICINOT_04062	1.15e-07	52.8	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,2VSP2@28216|Betaproteobacteria,2KRBI@206351|Neisseriales	206351|Neisseriales	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
k59_1572290_1	485915.Dret_0599	1.02e-32	129.0	COG3464@1|root,COG3464@2|Bacteria,1R4DH@1224|Proteobacteria,43AQ4@68525|delta/epsilon subdivisions,2X63W@28221|Deltaproteobacteria,2MGXP@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM transposase IS204 IS1001 IS1096 IS1165 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,zf-ISL3
k59_1156340_1	395493.BegalDRAFT_1070	5.37e-14	72.0	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,1RS5K@1236|Gammaproteobacteria,462JJ@72273|Thiotrichales	72273|Thiotrichales	S	Bacterial protein of unknown function (DUF882)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
k59_1456482_1	1304865.JAGF01000001_gene3604	2.67e-139	427.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4F0IU@85016|Cellulomonadaceae	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_1041178_1	765912.Thimo_1946	1.16e-13	70.5	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1WX73@135613|Chromatiales	135613|Chromatiales	M	PFAM Three-deoxy-D-manno-octulosonic-acid transferase	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N,Kdo
k59_1041178_2	765912.Thimo_1981	9.46e-62	197.0	COG0726@1|root,COG0726@2|Bacteria,1MWR2@1224|Proteobacteria,1RP7J@1236|Gammaproteobacteria,1WXB3@135613|Chromatiales	135613|Chromatiales	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
k59_1572301_1	706587.Desti_3165	1.78e-33	122.0	COG0410@1|root,COG0410@2|Bacteria,1R9AG@1224|Proteobacteria,42KZN@68525|delta/epsilon subdivisions,2WJWX@28221|Deltaproteobacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_692392_1	680198.SCAB_7311	6.11e-06	47.8	COG1609@1|root,COG1609@2|Bacteria,2GK1X@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
k59_692392_2	31964.CMS2571	7.79e-23	97.8	COG1874@1|root,COG1874@2|Bacteria,2GMDT@201174|Actinobacteria,4FKIA@85023|Microbacteriaceae	201174|Actinobacteria	G	Beta-galactosidase trimerisation domain	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M
k59_1156354_1	177437.HRM2_25500	4.28e-19	82.0	2AGE3@1|root,316JX@2|Bacteria,1NHX8@1224|Proteobacteria,42X67@68525|delta/epsilon subdivisions,2WT7A@28221|Deltaproteobacteria,2MM7G@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
k59_692395_1	1123393.KB891316_gene1266	2.11e-37	137.0	COG2143@1|root,COG2143@2|Bacteria,1QDKY@1224|Proteobacteria,2WDTN@28216|Betaproteobacteria,1KSHJ@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Thioredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
k59_164590_1	1049564.TevJSym_ah00890	1.23e-63	199.0	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,1S40Q@1236|Gammaproteobacteria,1J5QA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_878602_1	985054.JQEZ01000002_gene3846	1.99e-18	86.3	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_878602_2	1280946.HY29_03945	7.69e-161	474.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria,43Z1B@69657|Hyphomonadaceae	28211|Alphaproteobacteria	Q	Amidohydrolase family	MA20_04810	-	3.5.1.82	ko:K01461	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_3
k59_700241_1	479435.Kfla_5919	6.09e-60	198.0	28NWB@1|root,2ZBU7@2|Bacteria,2GJ74@201174|Actinobacteria,4DQ8F@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF3027)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3027
k59_173294_2	395493.BegalDRAFT_1531	7.29e-38	137.0	COG0586@1|root,COG0586@2|Bacteria,1R5SJ@1224|Proteobacteria,1S274@1236|Gammaproteobacteria,463J5@72273|Thiotrichales	72273|Thiotrichales	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_1164292_1	521393.JH806633_gene1882	1.67e-13	71.6	COG3833@1|root,COG3833@2|Bacteria,2I2EZ@201174|Actinobacteria,4D4FY@85005|Actinomycetales	201174|Actinobacteria	P	ABC transporter permease	malG	-	-	ko:K15772	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
k59_1164292_2	1306174.JODP01000010_gene6987	1.26e-173	503.0	COG1175@1|root,COG1175@2|Bacteria,2GJGB@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	malF	-	-	ko:K15771	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1,TM_PBP2_N
k59_1581595_1	296591.Bpro_2167	9.98e-61	208.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,4AA5M@80864|Comamonadaceae	28216|Betaproteobacteria	I	Carbamoyl-phosphate synthase L chain, ATP-binding	pccA	-	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_1810681_1	1208321.D104_15480	7.34e-43	151.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,1XH2P@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_1810681_2	1122194.AUHU01000004_gene1501	1.24e-29	110.0	COG1393@1|root,COG1393@2|Bacteria,1MZ6S@1224|Proteobacteria,1S8TR@1236|Gammaproteobacteria,467VK@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Belongs to the ArsC family	yffB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
k59_1700375_1	84531.JMTZ01000006_gene3502	5.34e-150	434.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,1X4UN@135614|Xanthomonadales	135614|Xanthomonadales	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_1052140_2	1346791.M529_09550	1.78e-29	114.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria,2K18R@204457|Sphingomonadales	204457|Sphingomonadales	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_878618_1	1121035.AUCH01000003_gene1184	1.4e-06	50.1	COG3113@1|root,COG3113@2|Bacteria,1PJKD@1224|Proteobacteria,2VW6E@28216|Betaproteobacteria,2KXIR@206389|Rhodocyclales	206389|Rhodocyclales	S	STAS domain	-	-	-	ko:K07122	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	STAS_2
k59_878618_2	511.JT27_06975	5.55e-28	109.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,2VR85@28216|Betaproteobacteria,3T3N9@506|Alcaligenaceae	28216|Betaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents auxiliary component	ttg2D	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
k59_1638886_1	316274.Haur_2046	2.43e-34	130.0	COG0517@1|root,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k59_1164305_1	768671.ThimaDRAFT_1852	4.91e-21	85.1	2ETHX@1|root,33M1T@2|Bacteria,1NGGA@1224|Proteobacteria,1SGP8@1236|Gammaproteobacteria,1X17A@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1164305_2	572477.Alvin_1639	6.83e-33	116.0	2DPGF@1|root,331YU@2|Bacteria,1N6ZX@1224|Proteobacteria,1SDQJ@1236|Gammaproteobacteria,1WZ1Q@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1702032_1	680198.SCAB_80561	2.99e-13	71.2	COG4585@1|root,COG4585@2|Bacteria,2GM7E@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
k59_1702032_2	1385520.N802_09875	2.37e-29	111.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4FIPW@85021|Intrasporangiaceae	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1166364_1	1298863.AUEP01000002_gene1441	7.32e-56	195.0	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4DN57@85009|Propionibacteriales	201174|Actinobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_582510_1	797209.ZOD2009_03085	1.35e-26	105.0	COG0521@1|root,arCOG00214@2157|Archaea,2XWJF@28890|Euryarchaeota,23VB0@183963|Halobacteria	183963|Halobacteria	H	COG0521 Molybdopterin biosynthesis enzymes	moaB2	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
k59_582510_2	933262.AXAM01000031_gene3012	1.14e-12	67.8	COG2896@1|root,COG2896@2|Bacteria,1MXMH@1224|Proteobacteria,42NTM@68525|delta/epsilon subdivisions,2WKIQ@28221|Deltaproteobacteria,2MPJN@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_1054464_1	205922.Pfl01_4014	1.39e-63	202.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,1YP2J@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	E	GDSL-like Lipase/Acylhydrolase family	tesA	GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365	Lipase_GDSL_2
k59_880525_1	686340.Metal_1041	8.57e-75	248.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1XDY0@135618|Methylococcales	135618|Methylococcales	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_880525_2	1049564.TevJSym_af00510	3.64e-76	236.0	COG4122@1|root,COG4122@2|Bacteria,1RASF@1224|Proteobacteria,1S38Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
k59_701884_1	1121405.dsmv_2076	8.77e-40	140.0	COG3568@1|root,COG3568@2|Bacteria,1RBWV@1224|Proteobacteria,42QPA@68525|delta/epsilon subdivisions,2WMPU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
k59_701884_2	1317118.ATO8_16700	1.69e-07	52.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,4KKPV@93682|Roseivivax	28211|Alphaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_1166387_1	96561.Dole_0566	1.48e-132	386.0	COG0004@1|root,COG0004@2|Bacteria,1R50W@1224|Proteobacteria,42PKR@68525|delta/epsilon subdivisions,2WM8P@28221|Deltaproteobacteria,2MII5@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_1166391_1	1121106.JQKB01000170_gene5396	5.56e-08	59.7	COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,2TU4W@28211|Alphaproteobacteria,2JQB6@204441|Rhodospirillales	204441|Rhodospirillales	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SWIM
k59_762096_1	887062.HGR_05449	1.57e-67	218.0	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2VHCR@28216|Betaproteobacteria,4AAI7@80864|Comamonadaceae	28216|Betaproteobacteria	S	FAD dependent oxidoreductase	-	-	-	ko:K06954	-	-	-	-	ko00000	-	-	-	Amino_oxidase
k59_762096_2	582744.Msip34_1300	1.37e-45	155.0	COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,2VIZ9@28216|Betaproteobacteria,2KKWX@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Protein of unknown function (DUF1365)	-	-	-	ko:K09701	-	-	-	-	ko00000	-	-	-	DUF1365
k59_880542_1	1304865.JAGF01000001_gene1916	1.6e-159	480.0	COG0085@1|root,COG0085@2|Bacteria,2GJ81@201174|Actinobacteria,4F0Q4@85016|Cellulomonadaceae	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1640119_2	102129.Lepto7375DRAFT_1521	1.54e-32	122.0	COG2008@1|root,COG2008@2|Bacteria,1G4PN@1117|Cyanobacteria	1117|Cyanobacteria	E	Threonine aldolase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_762110_1	1218075.BAYA01000006_gene2433	6.55e-27	109.0	COG2995@1|root,COG2995@2|Bacteria,1RAQ9@1224|Proteobacteria,2VQ5G@28216|Betaproteobacteria,1K09Y@119060|Burkholderiaceae	28216|Betaproteobacteria	S	paraquat-inducible protein A	pqiA	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_762110_2	1121406.JAEX01000017_gene1912	5.06e-18	80.9	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,42R11@68525|delta/epsilon subdivisions,2WMWN@28221|Deltaproteobacteria,2MBFA@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
k59_641594_1	1283300.ATXB01000001_gene1078	6.42e-55	184.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1XECZ@135618|Methylococcales	135618|Methylococcales	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
k59_1582973_1	1123392.AQWL01000005_gene3192	2.33e-05	46.6	COG3193@1|root,COG3193@2|Bacteria,1RJ3X@1224|Proteobacteria,2WFMV@28216|Betaproteobacteria,1KSR6@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
k59_1582973_2	1122185.N792_09170	6.63e-44	145.0	COG1403@1|root,COG1403@2|Bacteria,1RGZQ@1224|Proteobacteria,1S5V4@1236|Gammaproteobacteria,1X6UP@135614|Xanthomonadales	135614|Xanthomonadales	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH
k59_1166423_1	1380354.JIAN01000010_gene3007	2.12e-32	122.0	2CA7I@1|root,30E5G@2|Bacteria,2IJ78@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_466233_1	870187.Thini_1202	3.79e-79	248.0	COG1295@1|root,COG1295@2|Bacteria,1NH82@1224|Proteobacteria,1S3T8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ribonuclease BN	-	-	-	-	-	-	-	-	-	-	-	-	Virul_fac_BrkB
k59_175086_1	631362.Thi970DRAFT_02659	1.11e-16	78.6	COG1269@1|root,COG1269@2|Bacteria,1QGFB@1224|Proteobacteria,1RQRW@1236|Gammaproteobacteria,1WWNC@135613|Chromatiales	135613|Chromatiales	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_175086_2	765911.Thivi_1776	7.87e-64	199.0	COG0636@1|root,COG0636@2|Bacteria,1REA9@1224|Proteobacteria,1S51I@1236|Gammaproteobacteria,1WY7C@135613|Chromatiales	135613|Chromatiales	C	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
k59_175086_3	768671.ThimaDRAFT_4693	8.95e-35	123.0	COG1436@1|root,COG1436@2|Bacteria,1MZUE@1224|Proteobacteria,1SATX@1236|Gammaproteobacteria,1WYZV@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_F
k59_1406297_1	391626.OAN307_c48680	1.32e-55	181.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TS16@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG1484 DNA replication protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_701923_1	1288494.EBAPG3_20970	1.68e-21	87.0	COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,2VTRD@28216|Betaproteobacteria,373C6@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
k59_701923_2	1249627.D779_2418	4.97e-73	225.0	COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,1RSM2@1236|Gammaproteobacteria,1WX5K@135613|Chromatiales	135613|Chromatiales	L	Belongs to the Nudix hydrolase family	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
k59_1812340_1	941449.dsx2_0365	8.31e-58	195.0	COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,42PU9@68525|delta/epsilon subdivisions,2WU8U@28221|Deltaproteobacteria,2M8K7@213115|Desulfovibrionales	28221|Deltaproteobacteria	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_1054531_1	1042377.AFPJ01000037_gene2871	9.32e-46	154.0	COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,466ZE@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Belongs to the UPF0234 family	yajQ	GO:0000049,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
k59_522491_1	1121015.N789_00810	1.15e-167	488.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1X3PI@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_522491_2	1161401.ASJA01000022_gene134	7.57e-96	290.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2TR1H@28211|Alphaproteobacteria,43WHR@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_175095_2	448385.sce7227	7.45e-78	241.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42P96@68525|delta/epsilon subdivisions,2WMVB@28221|Deltaproteobacteria,2YUCK@29|Myxococcales	28221|Deltaproteobacteria	P	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1054544_1	1122138.AQUZ01000005_gene2559	3.52e-51	176.0	COG0310@1|root,COG0310@2|Bacteria,2GK2U@201174|Actinobacteria,4DNYF@85009|Propionibacteriales	201174|Actinobacteria	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
k59_466255_1	1268622.AVS7_01705	4.03e-26	101.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2VR4X@28216|Betaproteobacteria,4ADXJ@80864|Comamonadaceae	28216|Betaproteobacteria	I	Cyclase dehydrase	ratA	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
k59_466255_2	1049564.TevJSym_ac01310	4.64e-200	568.0	COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1J5IR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_1054555_1	933262.AXAM01000013_gene1295	4.5e-11	58.2	COG1609@1|root,COG1609@2|Bacteria,1QW0S@1224|Proteobacteria,43BQP@68525|delta/epsilon subdivisions,2X71R@28221|Deltaproteobacteria,2MM94@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
k59_175110_2	497321.C664_19685	1.61e-29	112.0	COG2020@1|root,COG2020@2|Bacteria,1PPQV@1224|Proteobacteria,2VR3S@28216|Betaproteobacteria,2KYVU@206389|Rhodocyclales	206389|Rhodocyclales	O	methyltransferase activity	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	-
k59_1702125_1	253839.SSNG_01351	4.49e-28	117.0	COG3903@1|root,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
k59_1166483_1	439235.Dalk_3245	2.42e-34	126.0	COG0727@1|root,COG0727@2|Bacteria,1RIJV@1224|Proteobacteria,42U8U@68525|delta/epsilon subdivisions,2WPB4@28221|Deltaproteobacteria,2MKIE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
k59_350197_1	864069.MicloDRAFT_00070330	4.34e-75	238.0	COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,2UCIY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	High confidence in function and specificity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
k59_1812390_1	983545.Glaag_2288	2.21e-59	196.0	COG3509@1|root,COG3509@2|Bacteria,1NTIV@1224|Proteobacteria,1RZ9J@1236|Gammaproteobacteria,4651I@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase,Esterase_phd
k59_1406327_1	396588.Tgr7_0275	9.25e-115	354.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1WX60@135613|Chromatiales	135613|Chromatiales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_582587_1	572477.Alvin_1179	6.7e-105	311.0	COG0369@1|root,COG0369@2|Bacteria,1NCKQ@1224|Proteobacteria,1RR4U@1236|Gammaproteobacteria,1WX7N@135613|Chromatiales	135613|Chromatiales	P	PFAM Oxidoreductase FAD NAD(P)-binding	-	-	1.18.1.2,1.8.1.2	ko:K00380,ko:K02641	ko00195,ko00920,ko01100,ko01120,map00195,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
k59_762176_2	745014.OMB55_00020500	1.99e-22	104.0	COG4733@1|root,COG4733@2|Bacteria,1R55I@1224|Proteobacteria,1S5X2@1236|Gammaproteobacteria,1JB4V@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1640183_2	1123393.KB891326_gene21	1.23e-34	126.0	COG2426@1|root,COG2426@2|Bacteria,1N9Q5@1224|Proteobacteria	1224|Proteobacteria	S	Putative small multi-drug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
k59_350223_1	1379698.RBG1_1C00001G0821	6.95e-34	128.0	COG0798@1|root,COG0798@2|Bacteria,2NNWJ@2323|unclassified Bacteria	2|Bacteria	P	Sodium Bile acid symporter family	arsB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656	1.20.4.1	ko:K03325,ko:K03741	-	-	-	-	ko00000,ko01000,ko02000	2.A.59	-	iYO844.BSU25790	SBF
k59_1702164_1	640081.Dsui_0586	3.88e-36	137.0	COG3746@1|root,COG3746@2|Bacteria,1MY3M@1224|Proteobacteria,2VIIP@28216|Betaproteobacteria,2KUH1@206389|Rhodocyclales	206389|Rhodocyclales	P	phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1583035_1	931626.Awo_c24220	9.71e-22	99.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,25UT2@186806|Eubacteriaceae	186801|Clostridia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	phoR	-	2.7.13.3	ko:K07636,ko:K07652	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
k59_582612_1	572477.Alvin_0002	1.97e-39	142.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1WWQF@135613|Chromatiales	135613|Chromatiales	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	-	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_175174_1	378806.STAUR_1140	2.99e-10	60.8	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,42MX2@68525|delta/epsilon subdivisions,2WIUV@28221|Deltaproteobacteria,2YZE4@29|Myxococcales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_175174_2	1266914.ATUK01000010_gene1075	6.2e-74	233.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1WWNU@135613|Chromatiales	135613|Chromatiales	E	PFAM Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_1812461_1	1049564.TevJSym_ab00440	1.13e-88	281.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J8SM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Citrate transporter	sac1	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_1757473_1	1195246.AGRI_09145	1.79e-100	313.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,46544@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_1757477_2	1121374.KB891576_gene270	9.17e-26	97.8	COG2388@1|root,COG2388@2|Bacteria,1PN9M@1224|Proteobacteria,1SDBK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	GCN5-related N-acetyl-transferase	-	-	-	ko:K06975	-	-	-	-	ko00000	-	-	-	Acetyltransf_CG
k59_1757477_3	321955.AAGP01000018_gene2133	3.17e-53	194.0	COG3011@1|root,COG3011@2|Bacteria,2GMSU@201174|Actinobacteria,4F8PG@85019|Brevibacteriaceae	201174|Actinobacteria	S	Lipase maturation factor	LMF	-	-	-	-	-	-	-	-	-	-	-	LMF1
k59_232994_1	6087.XP_002168760.2	4.06e-06	50.4	KOG4705@1|root,KOG4705@2759|Eukaryota,39TCX@33154|Opisthokonta,3BFY2@33208|Metazoa	33208|Metazoa	S	RNA-DNA hybrid ribonuclease activity	RNASEH2B	GO:0001701,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0006139,GO:0006401,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007275,GO:0007346,GO:0008150,GO:0008152,GO:0008284,GO:0009056,GO:0009057,GO:0009117,GO:0009259,GO:0009790,GO:0009792,GO:0009892,GO:0009987,GO:0010389,GO:0010468,GO:0010564,GO:0010605,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019222,GO:0019439,GO:0019637,GO:0019693,GO:0031974,GO:0031981,GO:0032299,GO:0032501,GO:0032502,GO:0032991,GO:0034641,GO:0034655,GO:0042127,GO:0043009,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0046700,GO:0048145,GO:0048146,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048856,GO:0050789,GO:0050794,GO:0051726,GO:0055086,GO:0060255,GO:0065007,GO:0070013,GO:0071704,GO:0080134,GO:0080135,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901135,GO:1901360,GO:1901361,GO:1901575,GO:1901976,GO:1901987,GO:1901990,GO:1902749,GO:2000001,GO:2001020	-	ko:K10744	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	RNase_H2-Ydr279
k59_809361_2	871585.BDGL_003151	5.85e-11	63.5	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,3NK0T@468|Moraxellaceae	1236|Gammaproteobacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	dsbC	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
k59_1702207_1	1121439.dsat_2748	8.17e-145	418.0	2CE5F@1|root,2Z7YQ@2|Bacteria,1MXVM@1224|Proteobacteria,42Q53@68525|delta/epsilon subdivisions,2WJY4@28221|Deltaproteobacteria,2MEC1@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1702207_2	1121405.dsmv_1786	8.96e-93	271.0	2BS3Y@1|root,32M4R@2|Bacteria,1NT2U@1224|Proteobacteria,42YW3@68525|delta/epsilon subdivisions,2WTV7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1702207_3	1121439.dsat_2747	2.8e-51	161.0	2E3GE@1|root,32YF6@2|Bacteria,1N7MX@1224|Proteobacteria,42XUV@68525|delta/epsilon subdivisions,2WSST@28221|Deltaproteobacteria,2MCKM@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2188)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2188
k59_1465622_1	1049564.TevJSym_cx00010	7.02e-58	197.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria,1JAD3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_350292_1	264730.PSPPH_4789	2.02e-37	131.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria,1Z5I7@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO0053,iSDY_1059.SDY_4064	CTP_transf_like
k59_350292_2	754477.Q7C_601	4.64e-44	143.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,1S8ZV@1236|Gammaproteobacteria,460XB@72273|Thiotrichales	72273|Thiotrichales	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
k59_1812508_1	857087.Metme_3957	5.37e-14	72.8	2E3CB@1|root,30K1F@2|Bacteria,1PUFA@1224|Proteobacteria,1TI9H@1236|Gammaproteobacteria,1XGQ9@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4154)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4154
k59_1412745_2	660470.Theba_2548	1.03e-26	107.0	COG2222@1|root,COG2222@2|Bacteria	2|Bacteria	M	isomerase activity	frlB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016829,GO:0016835,GO:0016836,GO:0042802	-	ko:K10708	-	-	R08125	RC00053,RC01805	ko00000,ko01000	-	-	iSFV_1184.SFV_3377,iSFxv_1172.SFxv_3701	SIS
k59_121277_1	1122164.JHWF01000040_gene1390	1.85e-14	68.9	COG2154@1|root,COG2154@2|Bacteria,1RH99@1224|Proteobacteria,1SAUS@1236|Gammaproteobacteria,1JEIT@118969|Legionellales	118969|Legionellales	H	4-alpha-hydroxytetrahydrobiopterin dehydratase activity	phs	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
k59_121277_2	765911.Thivi_4070	2.63e-23	92.4	COG2010@1|root,COG2010@2|Bacteria,1N71Z@1224|Proteobacteria,1SF76@1236|Gammaproteobacteria,1WZJF@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_121277_3	105559.Nwat_2763	4.58e-113	338.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,1RNKP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	PFAM peptidase	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
k59_414515_1	323848.Nmul_A2519	1.61e-92	289.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2VHBY@28216|Betaproteobacteria,372CJ@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Asparagine synthase	asnB1	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
k59_766503_1	670307.HYPDE_41533	6.45e-90	273.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,2TRV3@28211|Alphaproteobacteria,3N68S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	PhoH-like protein	phoH	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
k59_179905_1	518766.Rmar_1656	4.96e-120	373.0	COG0019@1|root,COG0527@1|root,COG0019@2|Bacteria,COG0527@2|Bacteria,4NFWR@976|Bacteroidetes,1FIKN@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Belongs to the Orn Lys Arg decarboxylase class-II family	-	-	2.7.2.4,4.1.1.20	ko:K00928,ko:K12526	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00451,R00480	RC00002,RC00043,RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_945241_1	350058.Mvan_1843	3.02e-29	114.0	COG1985@1|root,COG1985@2|Bacteria,2INYS@201174|Actinobacteria	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_945241_2	416591.Tlet_1576	2.63e-25	101.0	COG2021@1|root,COG2021@2|Bacteria	2|Bacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Abhydrolase_1,Abhydrolase_6
k59_945241_3	795797.C497_14947	0.000569	43.9	COG0596@1|root,arCOG01648@2157|Archaea,2XX6N@28890|Euryarchaeota,23VPX@183963|Halobacteria	183963|Halobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
k59_886428_1	1122603.ATVI01000006_gene41	1.7e-36	131.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1X3U6@135614|Xanthomonadales	135614|Xanthomonadales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_886428_2	203122.Sde_3966	2.06e-24	101.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,465I5@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	e_coli_core.b3732,iAF1260.b3732,iAPECO1_1312.APECO1_2729,iB21_1397.B21_03560,iBWG_1329.BWG_3423,iE2348C_1286.E2348C_4042,iEC042_1314.EC042_4119,iEC55989_1330.EC55989_4207,iECABU_c1320.ECABU_c42160,iECBD_1354.ECBD_4300,iECB_1328.ECB_03616,iECDH10B_1368.ECDH10B_3919,iECDH1ME8569_1439.ECDH1ME8569_3620,iECD_1391.ECD_03616,iECED1_1282.ECED1_4422,iECH74115_1262.ECH74115_5168,iECIAI1_1343.ECIAI1_3916,iECIAI39_1322.ECIAI39_4336,iECNA114_1301.ECNA114_3881,iECO103_1326.ECO103_4426,iECO111_1330.ECO111_4566,iECO26_1355.ECO26_4846,iECOK1_1307.ECOK1_4181,iECP_1309.ECP_3931,iECS88_1305.ECS88_4154,iECSE_1348.ECSE_4022,iECSF_1327.ECSF_3580,iECSP_1301.ECSP_4782,iECUMN_1333.ECUMN_4262,iECW_1372.ECW_m4035,iECs_1301.ECs4674,iEKO11_1354.EKO11_4613,iETEC_1333.ETEC_4023,iEcDH1_1363.EcDH1_4235,iEcE24377_1341.EcE24377A_4247,iEcSMS35_1347.EcSMS35_4100,iEcolC_1368.EcolC_4262,iG2583_1286.G2583_4528,iJO1366.b3732,iJR904.b3732,iLF82_1304.LF82_0194,iNRG857_1313.NRG857_18585,iPC815.YPO4121,iSFV_1184.SFV_3758,iSF_1195.SF3812,iSFxv_1172.SFxv_4154,iSSON_1240.SSON_3887,iS_1188.S3956,iSbBS512_1146.SbBS512_E4189,iUMN146_1321.UM146_18850,iUMNK88_1353.UMNK88_4544,iUTI89_1310.UTI89_C4285,iWFL_1372.ECW_m4035,iY75_1357.Y75_RS18410,iZ_1308.Z5230,ic_1306.c4658	ATP-synt_ab,ATP-synt_ab_N
k59_649583_1	247639.MGP2080_03080	7.35e-76	253.0	COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,1J5SG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k59_1647764_1	1009370.ALO_09719	2.68e-19	94.4	COG0668@1|root,COG0668@2|Bacteria,1U54A@1239|Firmicutes,4H6Y4@909932|Negativicutes	909932|Negativicutes	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
k59_1297493_1	1429916.X566_05135	3.15e-27	105.0	COG0500@1|root,COG2226@2|Bacteria,1MVSY@1224|Proteobacteria,2TTNQ@28211|Alphaproteobacteria,3JU9Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	methionine biosynthesis protein (MetW)	metW	-	-	-	-	-	-	-	-	-	-	-	MetW
k59_1297493_2	717785.HYPMC_4073	7.07e-77	240.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2TQYA@28211|Alphaproteobacteria,3N86Q@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_121297_1	1304885.AUEY01000030_gene2419	1.1e-43	156.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42M01@68525|delta/epsilon subdivisions,2WJ7M@28221|Deltaproteobacteria,2MHMW@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_239060_1	2340.JV46_20400	8.62e-39	142.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1J5MF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NADH ubiquinone oxidoreductase subunit	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_239060_2	1097668.BYI23_A016880	1.56e-08	59.3	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria,1JZPI@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1236712_1	717785.HYPMC_3180	4.14e-60	201.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2TUAD@28211|Alphaproteobacteria,3N89M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	PQQ-like domain	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
k59_1706287_2	742738.HMPREF9460_02432	7.48e-08	52.4	COG1918@1|root,COG1918@2|Bacteria,1VFH1@1239|Firmicutes,24R3D@186801|Clostridia,269QC@186813|unclassified Clostridiales	186801|Clostridia	P	FeoA	feoA	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
k59_886451_1	396588.Tgr7_2336	4.35e-103	300.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,1RMW0@1236|Gammaproteobacteria,1WWG3@135613|Chromatiales	135613|Chromatiales	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
k59_1471374_1	768671.ThimaDRAFT_3344	3.98e-145	418.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1WW6K@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_239065_1	471852.Tcur_1002	2.94e-38	140.0	COG1218@1|root,COG1218@2|Bacteria,2GMW7@201174|Actinobacteria,4EGRG@85012|Streptosporangiales	201174|Actinobacteria	P	Inositol monophosphatase family	cysQ_1	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
k59_766526_2	1121440.AUMA01000012_gene1350	4.67e-33	120.0	COG3238@1|root,COG3238@2|Bacteria,1N6ZC@1224|Proteobacteria,42TS3@68525|delta/epsilon subdivisions,2WQN1@28221|Deltaproteobacteria,2MCJM@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Putative inner membrane exporter, YdcZ	-	-	-	ko:K09936	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.7.21	-	-	DMT_YdcZ
k59_122141_1	582899.Hden_2496	4.61e-105	310.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2TR1H@28211|Alphaproteobacteria,3N6CK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_1298786_2	768710.DesyoDRAFT_2511	6.59e-32	117.0	COG4994@1|root,COG4994@2|Bacteria,1VC72@1239|Firmicutes,24JSH@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
k59_1061886_1	471853.Bcav_2901	2.57e-63	221.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GM2E@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD2	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_65900_2	1121372.AULK01000002_gene928	2.74e-43	146.0	COG3118@1|root,COG3118@2|Bacteria,2IHQV@201174|Actinobacteria,4FSJP@85023|Microbacteriaceae	201174|Actinobacteria	O	Thioredoxin	-	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
k59_65900_3	1464048.JNZS01000010_gene5095	1.89e-18	83.2	COG1357@1|root,COG1357@2|Bacteria,2GM3W@201174|Actinobacteria,4DA0P@85008|Micromonosporales	201174|Actinobacteria	S	Pentapeptide repeat protein	yybG	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
k59_887715_1	472759.Nhal_2479	3.04e-61	208.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1WXWN@135613|Chromatiales	135613|Chromatiales	I	PFAM 3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_1707134_1	1304883.KI912532_gene2809	3.28e-26	103.0	COG3658@1|root,COG3658@2|Bacteria,1N28F@1224|Proteobacteria,2VU1H@28216|Betaproteobacteria,2KWAW@206389|Rhodocyclales	206389|Rhodocyclales	C	Dihaem cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	DHC
k59_1178778_1	1499967.BAYZ01000028_gene1309	1.48e-129	372.0	COG0410@1|root,COG0410@2|Bacteria,2NNXF@2323|unclassified Bacteria	2|Bacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_1178778_2	1000565.METUNv1_03275	6.74e-41	144.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJM6@28216|Betaproteobacteria,2KVIX@206389|Rhodocyclales	206389|Rhodocyclales	E	branched-chain amino acid	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_1589357_1	224911.27351744	1.59e-19	92.8	COG2984@1|root,COG4191@1|root,COG2984@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,3JT51@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA
k59_1530857_1	1386089.N865_08675	1.22e-101	312.0	COG0155@1|root,COG0155@2|Bacteria,2GJRN@201174|Actinobacteria,4FF1X@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	sir	GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016002,GO:0016053,GO:0016491,GO:0016667,GO:0016673,GO:0019344,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.7.7.1,1.8.7.1	ko:K00366,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_1472559_1	435908.IDSA_09980	8.85e-10	58.5	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,2QFAW@267893|Idiomarinaceae	1236|Gammaproteobacteria	G	catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_4960	F_bP_aldolase
k59_1472559_2	1280950.HJO_12891	9.82e-07	53.5	290UJ@1|root,2ZNGJ@2|Bacteria,1RBSP@1224|Proteobacteria,2UIQD@28211|Alphaproteobacteria,43Y3Y@69657|Hyphomonadaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1413744_1	858619.CVAR_2413	2.41e-08	54.3	COG0081@1|root,COG0081@2|Bacteria,2GM51@201174|Actinobacteria,22JPW@1653|Corynebacteriaceae	201174|Actinobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_1413744_2	765913.ThidrDRAFT_1728	3.46e-23	93.6	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1WXDE@135613|Chromatiales	135613|Chromatiales	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_591893_1	1121017.AUFG01000002_gene2813	3.11e-60	194.0	COG1309@1|root,COG1309@2|Bacteria,2HQXF@201174|Actinobacteria,4FHR9@85021|Intrasporangiaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_887721_1	1123237.Salmuc_00331	4.1e-103	311.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	istA	-	-	-	-	-	-	-	-	-	-	-	rve
k59_1002144_2	1454010.JEOE01000020_gene2596	2.01e-85	264.0	COG0836@1|root,COG0836@2|Bacteria,2GIRM@201174|Actinobacteria,4F20H@85016|Cellulomonadaceae	201174|Actinobacteria	M	Nucleotidyl transferase	manC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_180865_1	1203554.HMPREF1476_01834	4.3e-78	240.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VIKC@28216|Betaproteobacteria,4PQCI@995019|Sutterellaceae	28216|Betaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.3.5.4	ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
k59_180865_2	765914.ThisiDRAFT_1964	8.8e-75	244.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales	135613|Chromatiales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	-	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1707142_1	697282.Mettu_0336	9.25e-19	86.3	COG1368@1|root,COG1368@2|Bacteria,1RG6W@1224|Proteobacteria,1RY34@1236|Gammaproteobacteria,1XFZX@135618|Methylococcales	135618|Methylococcales	M	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_1707142_2	768671.ThimaDRAFT_0819	4.34e-24	99.4	COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,1RREE@1236|Gammaproteobacteria,1WWMU@135613|Chromatiales	135613|Chromatiales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_887725_1	1047013.AQSP01000115_gene365	1.6e-84	267.0	COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria	2|Bacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	pilB	-	-	ko:K02454,ko:K02504,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
k59_65917_1	644283.Micau_2483	3.59e-100	300.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,4D98A@85008|Micromonosporales	201174|Actinobacteria	V	COG1131 ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_180866_1	1267533.KB906736_gene1139	9.91e-55	178.0	COG1136@1|root,COG1136@2|Bacteria,3Y2J0@57723|Acidobacteria,2JIKD@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1648702_1	296591.Bpro_0343	2.25e-20	90.1	COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,2WFFD@28216|Betaproteobacteria,4AGEC@80864|Comamonadaceae	28216|Betaproteobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
k59_1648702_2	1082931.KKY_3647	8.47e-08	52.4	COG0006@1|root,COG0006@2|Bacteria,1MVX5@1224|Proteobacteria,2TRMK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Xaa-Pro aminopeptidase	-	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
k59_1472570_1	1049564.TevJSym_aa01660	6.13e-37	125.0	COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,1S8RT@1236|Gammaproteobacteria,1J6MP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
k59_1472570_2	519989.ECTPHS_00180	5.84e-58	186.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria,1WY0M@135613|Chromatiales	135613|Chromatiales	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
k59_1472570_3	1283300.ATXB01000001_gene1889	9.46e-46	154.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,1RMWC@1236|Gammaproteobacteria,1XDQV@135618|Methylococcales	135618|Methylococcales	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
k59_1002148_1	1095767.CAHD01000004_gene2448	2.29e-08	58.2	COG1158@1|root,COG1158@2|Bacteria	2|Bacteria	K	DNA-templated transcription, termination	rho	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_65919_1	94122.Shewana3_3109	4.84e-13	68.6	2C5U9@1|root,2Z9NJ@2|Bacteria,1R6D0@1224|Proteobacteria,1S1VT@1236|Gammaproteobacteria,2QAAI@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
k59_65919_2	991905.SL003B_2986	1.16e-189	543.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2TRU8@28211|Alphaproteobacteria,4BPMM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF853)	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
k59_415474_1	357809.Cphy_0144	4.96e-71	221.0	COG0177@1|root,COG0177@2|Bacteria,1TRAK@1239|Firmicutes,24899@186801|Clostridia,21Z5H@1506553|Lachnoclostridium	186801|Clostridia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_826329_1	2340.JV46_04770	2.75e-98	311.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1J4XZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_887739_1	765912.Thimo_2262	1.01e-17	80.1	COG1394@1|root,COG1394@2|Bacteria,1RJ1P@1224|Proteobacteria,1S75D@1236|Gammaproteobacteria,1WYND@135613|Chromatiales	135613|Chromatiales	C	ATP synthase subunit D	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
k59_887739_3	765911.Thivi_1788	1.75e-11	62.8	COG1394@1|root,COG1394@2|Bacteria,1PA1A@1224|Proteobacteria,1S17V@1236|Gammaproteobacteria,1WWE8@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
k59_1298824_1	686340.Metal_1707	7.41e-47	174.0	COG0577@1|root,COG0577@2|Bacteria,1PJZX@1224|Proteobacteria,1RU56@1236|Gammaproteobacteria,1XDTW@135618|Methylococcales	135618|Methylococcales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_359398_4	1415778.JQMM01000001_gene1035	1.73e-29	111.0	COG3091@1|root,COG3091@2|Bacteria,1N07A@1224|Proteobacteria,1S9E8@1236|Gammaproteobacteria,1J74J@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	SprT homologues.	sprT	-	-	ko:K02742	-	-	-	-	ko00000	-	-	-	SprT-like,Zn_ribbon_SprT
k59_1178800_1	37919.EP51_32895	4.17e-93	294.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,4FURR@85025|Nocardiaceae	201174|Actinobacteria	P	Arylsulfatase	atsB	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF1269,Sulfatase
k59_709203_1	396588.Tgr7_0439	7.79e-85	266.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1WWXH@135613|Chromatiales	135613|Chromatiales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1472597_1	765912.Thimo_0793	5.06e-68	229.0	COG3299@1|root,COG3299@2|Bacteria,1PF9H@1224|Proteobacteria,1SXC0@1236|Gammaproteobacteria,1X1IG@135613|Chromatiales	135613|Chromatiales	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
k59_122171_1	198214.SF0365	6.81e-09	65.1	COG0790@1|root,COG2849@1|root,COG0790@2|Bacteria,COG2849@2|Bacteria,1MWPA@1224|Proteobacteria,1RPI3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	COG0790 FOG TPR repeat, SEL1 subfamily	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	MORN_2,Pkinase,Sel1
k59_1472599_1	1197706.AKKK01000006_gene1130	1.19e-42	151.0	COG0745@1|root,COG0745@2|Bacteria,2ICPT@201174|Actinobacteria	201174|Actinobacteria	T	Pfam Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_1589391_1	1122201.AUAZ01000006_gene3891	4.18e-55	178.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,466ZZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	COG2755 Lysophospholipase L1 and related esterases	tesA	GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365	Lipase_GDSL_2
k59_1589391_2	1453496.AT03_09880	1.56e-23	101.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	fadD	GO:0001676,GO:0003674,GO:0003824,GO:0004467,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006635,GO:0006637,GO:0006644,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009898,GO:0009987,GO:0015645,GO:0016020,GO:0016042,GO:0016054,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019395,GO:0019637,GO:0019693,GO:0019752,GO:0030258,GO:0031406,GO:0032787,GO:0033293,GO:0033865,GO:0033875,GO:0034032,GO:0034440,GO:0034641,GO:0035383,GO:0036041,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046395,GO:0046483,GO:0050896,GO:0051186,GO:0055086,GO:0055114,GO:0070538,GO:0071704,GO:0071944,GO:0072329,GO:0072521,GO:0090407,GO:0098552,GO:0098562,GO:1901135,GO:1901360,GO:1901564,GO:1901575,GO:1901576	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	iSF_1195.SF1423,iSFxv_1172.SFxv_1611,iS_1188.S1538	AMP-binding,AMP-binding_C
k59_1648727_1	439481.Aboo_0120	7.37e-06	53.9	COG0642@1|root,COG2202@1|root,COG2203@1|root,arCOG06712@1|root,arCOG02334@2157|Archaea,arCOG02369@2157|Archaea,arCOG06219@2157|Archaea,arCOG06712@2157|Archaea,2Y6CZ@28890|Euryarchaeota,3F36F@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_9
k59_240489_1	936548.HMPREF1136_0401	1.5e-06	55.5	COG2390@1|root,COG2390@2|Bacteria,2GMIM@201174|Actinobacteria,4D3RH@85005|Actinomycetales	201174|Actinobacteria	K	sugar-binding domain protein	-	-	-	ko:K05346	-	-	-	-	ko00000,ko03000	-	-	-	HTH_23,HTH_28,MarR_2,Sigma70_r4,Sugar-bind
k59_1826977_2	765914.ThisiDRAFT_1964	5.03e-60	203.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales	135613|Chromatiales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	-	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_6607_1	1049564.TevJSym_bg00250	6.75e-102	313.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,1J4NX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	von Willebrand factor (vWF) type A domain	norD	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_2
k59_1178823_1	472759.Nhal_2453	2.21e-39	139.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1WXRN@135613|Chromatiales	135613|Chromatiales	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_1178823_2	565045.NOR51B_24	5.56e-08	56.2	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,1RN0Z@1236|Gammaproteobacteria,1J5AE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_887776_1	257310.BB3329	5.04e-27	108.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2VIWB@28216|Betaproteobacteria,3T219@506|Alcaligenaceae	28216|Betaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	ccoN	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_887776_2	1249627.D779_0401	3.32e-96	285.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1WWQ7@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_1119556_1	1160718.SU9_16632	4.76e-29	117.0	COG0085@1|root,COG0085@2|Bacteria,2GJ81@201174|Actinobacteria	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1354917_1	765912.Thimo_1256	1.01e-111	345.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales	135613|Chromatiales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_891621_1	1499967.BAYZ01000019_gene6266	2.06e-41	150.0	COG2304@1|root,COG2304@2|Bacteria,2NP2F@2323|unclassified Bacteria	2|Bacteria	S	von Willebrand factor (vWF) type A domain	batB	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
k59_245816_2	1122622.ATWJ01000010_gene1299	1.15e-39	147.0	COG3349@1|root,COG3349@2|Bacteria,2I7PZ@201174|Actinobacteria	201174|Actinobacteria	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
k59_653470_1	1454010.JEOE01000033_gene2938	4.46e-61	192.0	COG2755@1|root,COG2755@2|Bacteria,2IA8J@201174|Actinobacteria,4F16N@85016|Cellulomonadaceae	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
k59_1242860_2	2340.JV46_17650	1.24e-59	189.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1J5XB@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins	iscR	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
k59_71039_2	2055.JNXA01000003_gene4617	2.98e-82	253.0	COG3285@1|root,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4GD11@85026|Gordoniaceae	201174|Actinobacteria	L	DNA primase, small subunit	ligD	-	-	-	-	-	-	-	-	-	-	-	DNA_primase_S
k59_951748_1	1121013.P873_08945	1.4e-29	120.0	COG2267@1|root,COG2267@2|Bacteria,1QTZP@1224|Proteobacteria,1RPB9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
k59_1832091_1	1713.JOFV01000010_gene1201	5.88e-91	278.0	COG0201@1|root,COG0201@2|Bacteria,2GJ26@201174|Actinobacteria,4F0MV@85016|Cellulomonadaceae	201174|Actinobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_1832092_1	551115.Aazo_3204	2.68e-58	193.0	COG0598@1|root,COG0598@2|Bacteria,1G1AG@1117|Cyanobacteria,1HJYZ@1161|Nostocales	1117|Cyanobacteria	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_536830_1	187272.Mlg_0349	2.65e-21	88.6	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1WX8T@135613|Chromatiales	135613|Chromatiales	K	Belongs to the UPF0301 (AlgH) family	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_536830_2	323261.Noc_0367	1.68e-38	134.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria,1WYAH@135613|Chromatiales	135613|Chromatiales	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
k59_301905_1	582899.Hden_2571	1.51e-121	368.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,2TS8B@28211|Alphaproteobacteria,3N6EA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	ATP-dependent DNA helicase RecQ	recQ	GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008270,GO:0009295,GO:0009378,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0017117,GO:0030894,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033202,GO:0033554,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043142,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1904949	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
k59_1832099_1	519989.ECTPHS_14156	9.7e-69	211.0	COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,1RSJY@1236|Gammaproteobacteria,1WY4B@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_419167_1	240016.ABIZ01000001_gene2548	0.000282	46.6	COG3900@1|root,COG3900@2|Bacteria	2|Bacteria	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
k59_892790_2	765911.Thivi_2459	1.16e-87	268.0	COG2863@1|root,COG2863@2|Bacteria,1R6DK@1224|Proteobacteria,1S0NK@1236|Gammaproteobacteria,1WWZZ@135613|Chromatiales	135613|Chromatiales	C	PFAM Cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k59_247474_1	247634.GPB2148_1284	4.14e-127	371.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1J58N@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_951774_1	406817.XNC1_0228	3.58e-21	99.0	COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	belongs to the aspartokinase family	metL	GO:0003674,GO:0003824,GO:0004072,GO:0004412,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009090,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.3,2.7.2.4	ko:K12524,ko:K12525	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	iUMNK88_1353.UMNK88_4778,iYL1228.KPN_04234	AA_kinase,ACT_7,Homoserine_dh,NAD_binding_3
k59_477996_1	367299.JOEE01000003_gene2758	5.65e-147	437.0	COG0525@1|root,COG0525@2|Bacteria,2GK8H@201174|Actinobacteria,4FF4K@85021|Intrasporangiaceae	201174|Actinobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_364548_1	1262915.BN574_01316	2e-08	59.7	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4H3RX@909932|Negativicutes	909932|Negativicutes	D	Tyrosine recombinase XerD	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
k59_364551_1	136273.GY22_03860	3.35e-65	216.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,1W8QK@1268|Micrococcaceae	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
k59_1832112_1	1408254.T458_16800	6.67e-42	143.0	COG0669@1|root,COG0669@2|Bacteria,1V3MR@1239|Firmicutes,4HH47@91061|Bacilli,26TVK@186822|Paenibacillaceae	91061|Bacilli	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
k59_1417849_1	446466.Cfla_0220	1.3e-73	237.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4F0VU@85016|Cellulomonadaceae	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	fbpC	-	-	ko:K02052,ko:K02062	ko02010,ko02024,map02010,map02024	M00191,M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.19	-	-	ABC_tran,TOBE_2
k59_364555_1	471853.Bcav_3414	9.94e-49	171.0	COG4129@1|root,COG4129@2|Bacteria,2GIR7@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	FUSC_2
k59_364555_2	1713.JOFV01000004_gene3332	7.87e-31	112.0	COG0723@1|root,COG0723@2|Bacteria,2I2JE@201174|Actinobacteria,4F1HF@85016|Cellulomonadaceae	201174|Actinobacteria	C	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
k59_71081_1	231434.JQJH01000005_gene2141	9.42e-42	140.0	COG1320@1|root,COG1320@2|Bacteria,1N3BA@1224|Proteobacteria,2UDGG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Na+/H+ antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_830267_2	187272.Mlg_2622	1.05e-216	609.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales	135613|Chromatiales	P	PFAM TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
k59_1534454_1	472759.Nhal_3898	1.22e-98	296.0	COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,1WW4G@135613|Chromatiales	135613|Chromatiales	P	PFAM CBS domain	-	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
k59_1652630_1	1172179.AUKV01000005_gene6006	3.51e-133	387.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_1652630_2	324602.Caur_1974	3.75e-19	92.4	COG0508@1|root,COG0508@2|Bacteria,2G619@200795|Chloroflexi,374T7@32061|Chloroflexia	32061|Chloroflexia	C	catalytic domain of components of various dehydrogenase complexes	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_184764_1	396588.Tgr7_2778	6.14e-109	346.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales	135613|Chromatiales	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_1304011_1	1163617.SCD_n00649	6.66e-93	276.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2VGZH@28216|Betaproteobacteria	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
k59_13804_1	279714.FuraDRAFT_3200	2.24e-56	193.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2VHR9@28216|Betaproteobacteria,2KPPS@206351|Neisseriales	206351|Neisseriales	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
k59_830272_1	1144312.PMI09_03741	3.93e-43	158.0	COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,2TTBA@28211|Alphaproteobacteria,4BAZE@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_951800_1	115417.EPrPW00000019269	1.2e-39	143.0	COG0421@1|root,KOG1562@2759|Eukaryota,1MFGR@121069|Pythiales	121069|Pythiales	E	Spermine synthase. Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synt_N,Spermine_synth
k59_951800_2	70601.3258436	1.32e-30	114.0	COG1586@1|root,arCOG00279@2157|Archaea,2XYBE@28890|Euryarchaeota,243ZV@183968|Thermococci	183968|Thermococci	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speH	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
k59_713075_1	479432.Sros_0525	9.41e-82	265.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4EGHS@85012|Streptosporangiales	201174|Actinobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_1832137_1	1049564.TevJSym_ad00560	1.99e-85	271.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1J5XD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2
k59_247522_1	1049564.TevJSym_aq00560	2.31e-151	447.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1J4RW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA helicase	uvrD	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0042802,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_1832138_1	880072.Desac_0380	5.53e-77	242.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MXG@68525|delta/epsilon subdivisions,2WJ6G@28221|Deltaproteobacteria,2MQ3U@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	aminotransferase, class I and II	-	-	2.6.1.1	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_247525_1	1303518.CCALI_02577	2.36e-84	261.0	COG1453@1|root,COG1453@2|Bacteria	2|Bacteria	S	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
k59_1182840_1	314287.GB2207_06528	6.54e-101	305.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1J53P@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Ammonium Transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_892827_2	1123257.AUFV01000007_gene122	6.33e-31	116.0	COG3151@1|root,COG3151@2|Bacteria,1MYG8@1224|Proteobacteria,1S7P6@1236|Gammaproteobacteria,1X7UD@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1249)	-	-	-	ko:K09920	-	-	-	-	ko00000	-	-	-	DUF1249
k59_364583_1	471853.Bcav_3598	2.53e-121	360.0	COG0362@1|root,COG0362@2|Bacteria,2GJ2J@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
k59_1005265_1	1185652.USDA257_c03720	1.42e-17	85.1	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2TRND@28211|Alphaproteobacteria,4BA30@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	acsA1	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1005265_2	1463825.JNXC01000003_gene3971	0.00014	45.8	COG0477@1|root,COG2814@2|Bacteria,2GJK6@201174|Actinobacteria,4DY6I@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Drug resistance transporter Bcr CflA subfamily	bcr	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_1067426_1	1172188.KB911821_gene1379	8.24e-94	284.0	COG0686@1|root,COG0686@2|Bacteria,2GKMN@201174|Actinobacteria,4FFPH@85021|Intrasporangiaceae	201174|Actinobacteria	E	alanine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_1768965_2	1283300.ATXB01000001_gene1303	4.59e-44	151.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,1RSHS@1236|Gammaproteobacteria,1XEZ8@135618|Methylococcales	135618|Methylococcales	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	-	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
k59_713089_1	765914.ThisiDRAFT_1590	5.69e-105	323.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,1WWF4@135613|Chromatiales	135613|Chromatiales	S	ABC transporter	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_71111_1	1386089.N865_10920	4.61e-12	70.1	COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4FEF5@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Belongs to the long-chain O-acyltransferase family	tgs1	GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
k59_1122636_1	996637.SGM_3168	1.46e-28	105.0	COG0197@1|root,COG0197@2|Bacteria,2IFEI@201174|Actinobacteria	201174|Actinobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
k59_1122636_2	1123065.ATWL01000003_gene891	3.77e-33	122.0	COG0092@1|root,COG0092@2|Bacteria,2GKF1@201174|Actinobacteria	201174|Actinobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_1304042_1	1265505.ATUG01000002_gene1433	6.76e-66	215.0	COG3023@1|root,COG3023@2|Bacteria,1PD4C@1224|Proteobacteria,42PQW@68525|delta/epsilon subdivisions,2WK9V@28221|Deltaproteobacteria,2MI3K@213118|Desulfobacterales	28221|Deltaproteobacteria	V	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2
k59_1242951_1	446466.Cfla_0834	3.61e-24	95.9	COG2331@1|root,COG2331@2|Bacteria,2IQHE@201174|Actinobacteria	201174|Actinobacteria	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
k59_1832161_1	1121403.AUCV01000009_gene1466	1.51e-74	225.0	2DKVG@1|root,30GRY@2|Bacteria,1RDQT@1224|Proteobacteria,42V8G@68525|delta/epsilon subdivisions,2WRP8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
k59_1832161_2	65093.PCC7418_1211	6.3e-05	45.1	COG0297@1|root,COG0297@2|Bacteria,1G0PX@1117|Cyanobacteria	1117|Cyanobacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
k59_1417898_1	266117.Rxyl_1038	1.63e-38	144.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4CPR5@84995|Rubrobacteria	84995|Rubrobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
k59_1832172_1	1112217.PPL19_05435	8.32e-67	217.0	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
k59_1122647_1	471853.Bcav_0611	6.24e-160	468.0	COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_364621_1	349124.Hhal_2379	2.28e-10	66.2	2DT83@1|root,33J44@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_654414_1	1210884.HG799462_gene8227	1.33e-21	100.0	2DQIY@1|root,3375N@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1534498_1	367299.JOEE01000001_gene2167	6.11e-105	323.0	COG0480@1|root,COG0480@2|Bacteria,2GKB3@201174|Actinobacteria,4FEM3@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1534498_2	1033736.CAHK01000037_gene2492	4.06e-22	89.0	COG0049@1|root,COG0049@2|Bacteria,2GMVW@201174|Actinobacteria,4F88W@85019|Brevibacteriaceae	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_1358541_1	985054.JQEZ01000002_gene3589	1.8e-34	127.0	COG1011@1|root,COG1011@2|Bacteria,1MVWN@1224|Proteobacteria,2TS5K@28211|Alphaproteobacteria,4NBAY@97050|Ruegeria	28211|Alphaproteobacteria	S	Haloacid dehalogenase, type II	dehII	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
k59_1477995_1	1125863.JAFN01000001_gene2907	1.41e-77	249.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
k59_1592874_1	1232410.KI421426_gene1467	1.37e-12	69.7	2E5SP@1|root,330H2@2|Bacteria,1NDBY@1224|Proteobacteria	1224|Proteobacteria	S	YMGG-like Gly-zipper	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_OmpA,Gly-zipper_YMGG
k59_184829_2	768671.ThimaDRAFT_1387	8.01e-79	241.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RM9H@1236|Gammaproteobacteria,1WWID@135613|Chromatiales	135613|Chromatiales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_1067481_1	1038859.AXAU01000030_gene6763	4.03e-61	203.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,3JVHX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_247606_1	1410619.SRDD_27870	1.64e-99	309.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,1RMHR@1236|Gammaproteobacteria,4026V@613|Serratia	1236|Gammaproteobacteria	Q	Alkyl sulfatase dimerisation	BDS1	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
k59_13895_1	870187.Thini_4445	5.67e-105	334.0	COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,1MXH9@1224|Proteobacteria,1RPQ6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane	-	-	2.3.2.3	ko:K07027,ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	2.A.1.3.37,4.D.2	-	-	DUF2156,LPG_synthase_TM
k59_13895_2	631362.Thi970DRAFT_02037	4.24e-41	146.0	COG3821@1|root,COG3821@2|Bacteria,1RDXR@1224|Proteobacteria,1S43M@1236|Gammaproteobacteria,1WZ29@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function, DUF599	-	-	-	-	-	-	-	-	-	-	-	-	DUF599
k59_1358543_2	398720.MED217_10964	1.58e-05	47.8	COG1670@1|root,COG1670@2|Bacteria,4NNBE@976|Bacteroidetes,1I22F@117743|Flavobacteriia	976|Bacteroidetes	J	Polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
k59_247608_1	1047013.AQSP01000144_gene876	2.42e-75	236.0	COG1088@1|root,COG1088@2|Bacteria,2NNRC@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008460,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019305,GO:0019438,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044464,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0048037,GO:0050662,GO:0051287,GO:0055086,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	4.2.1.46,4.2.1.76	ko:K01710,ko:K12450	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	M00793	R00293,R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3464	GDP_Man_Dehyd
k59_1478000_1	1440774.Y900_023745	1.2e-78	259.0	COG1452@1|root,COG1452@2|Bacteria,2GNM6@201174|Actinobacteria	201174|Actinobacteria	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
k59_541344_1	2340.JV46_08900	1.04e-67	213.0	COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,1S4KI@1236|Gammaproteobacteria,1J6WH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_541344_2	160488.PP_2346	2.68e-14	70.9	COG3212@1|root,COG3212@2|Bacteria	2|Bacteria	T	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
k59_541344_3	870187.Thini_1592	7.6e-89	268.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1S0IN@1236|Gammaproteobacteria,463NM@72273|Thiotrichales	72273|Thiotrichales	K	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_541344_4	2340.JV46_08950	5.21e-31	123.0	COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1RPMH@1236|Gammaproteobacteria,1J85K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_958161_1	1454004.AW11_02007	1.36e-96	311.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KQ5Y@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	V	MMPL family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_541345_1	765911.Thivi_0903	4.42e-113	339.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria,1WW5Y@135613|Chromatiales	135613|Chromatiales	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1422576_1	2340.JV46_25650	8.79e-26	110.0	COG3202@1|root,COG3202@2|Bacteria	2|Bacteria	C	ATP:ADP antiporter activity	CP_0465	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,TLC,cNMP_binding
k59_899168_1	1434929.X946_723	0.00061	41.2	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VJ7Q@28216|Betaproteobacteria,1KGMD@119060|Burkholderiaceae	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_899168_2	685727.REQ_00140	1e-09	65.9	COG1309@1|root,COG1309@2|Bacteria,2GMWH@201174|Actinobacteria,4G01S@85025|Nocardiaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_899168_3	1123257.AUFV01000002_gene2731	5.33e-10	60.1	COG4805@1|root,COG4805@2|Bacteria,1PIM6@1224|Proteobacteria,1RRW7@1236|Gammaproteobacteria,1X3BX@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
k59_423766_1	1249627.D779_0944	1.26e-64	199.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1WY7E@135613|Chromatiales	135613|Chromatiales	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
k59_423766_2	323261.Noc_1214	5.72e-94	299.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales	135613|Chromatiales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_189512_1	471853.Bcav_1166	1.03e-67	221.0	COG1316@1|root,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria	201174|Actinobacteria	K	cell envelope-related transcriptional attenuator	yvhJ	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
k59_130885_1	118168.MC7420_1316	4.94e-106	322.0	COG1397@1|root,COG1397@2|Bacteria,1GI84@1117|Cyanobacteria,1HEJK@1150|Oscillatoriales	1117|Cyanobacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
k59_423771_2	1515615.HQ41_04520	5.87e-31	125.0	COG0265@1|root,COG0265@2|Bacteria,4NFCS@976|Bacteroidetes,2FMUA@200643|Bacteroidia,22W8K@171551|Porphyromonadaceae	976|Bacteroidetes	O	deoxyribonuclease HsdR	degQ	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
k59_1714875_1	1279019.ARQK01000022_gene162	1.58e-104	310.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1T02D@1236|Gammaproteobacteria,1WW5T@135613|Chromatiales	135613|Chromatiales	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_1714875_2	565045.NOR51B_1466	7.61e-124	370.0	COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,1RN02@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	aminotransferase	phhC	-	2.6.1.1,2.6.1.57	ko:K00813,ko:K00832	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	M00024,M00025,M00034,M00040	R00355,R00694,R00734,R00896,R01731,R02433,R02619,R05052,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1310344_1	572477.Alvin_0420	3.86e-67	218.0	28JPV@1|root,2Z9FT@2|Bacteria,1PJPU@1224|Proteobacteria,1RZR6@1236|Gammaproteobacteria,1WVXD@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_774035_1	471853.Bcav_1928	5.55e-102	322.0	COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA2	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_1838545_1	247490.KSU1_B0100	3.69e-93	283.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_255406_1	713586.KB900536_gene383	2.14e-42	157.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria,1WXMT@135613|Chromatiales	135613|Chromatiales	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1484462_1	367299.JOEE01000007_gene41	1.21e-206	593.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4FETX@85021|Intrasporangiaceae	201174|Actinobacteria	C	Xanthine dehydrogenase	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_1074576_1	1123508.JH636439_gene847	1.15e-10	66.2	COG3746@1|root,COG3746@2|Bacteria,2IZ40@203682|Planctomycetes	203682|Planctomycetes	P	Phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
k59_1074576_2	1348635.BBJY01000029_gene2053	0.000103	45.4	COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,1RYFC@1236|Gammaproteobacteria,1XXB9@135623|Vibrionales	135623|Vibrionales	T	HPP family	-	-	-	-	-	-	-	-	-	-	-	-	HPP
k59_1363008_1	247639.MGP2080_07012	2.28e-43	158.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
k59_21846_1	935839.JAGJ01000016_gene2412	6.53e-50	167.0	COG0518@1|root,COG0518@2|Bacteria,2GKS1@201174|Actinobacteria,4F398@85017|Promicromonosporaceae	201174|Actinobacteria	F	Glutamine amidotransferase class-I	guaA_2	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
k59_1773360_1	1121405.dsmv_0965	1.92e-64	217.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2WJTT@28221|Deltaproteobacteria,2MITA@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
k59_899207_1	367299.JOEE01000004_gene1038	3.99e-75	239.0	COG3281@1|root,COG3281@2|Bacteria,2GKAP@201174|Actinobacteria,4FEUH@85021|Intrasporangiaceae	201174|Actinobacteria	G	Aminoglycoside phosphotransferase	mak	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576	2.7.1.175	ko:K16146	ko00500,ko01100,map00500,map01100	-	R09945	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
k59_1310364_2	382464.ABSI01000005_gene1406	4.2e-07	52.8	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	Apolipoprotein,VWA_2,YadA_anchor
k59_659205_1	290340.AAur_3610	6.17e-87	258.0	2BEKE@1|root,328BU@2|Bacteria,2HTSJ@201174|Actinobacteria,1WC9H@1268|Micrococcaceae	201174|Actinobacteria	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
k59_659205_2	290340.AAur_3609	5.02e-128	374.0	COG3497@1|root,COG3497@2|Bacteria,2GMJA@201174|Actinobacteria,1W9VA@1268|Micrococcaceae	201174|Actinobacteria	S	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
k59_1838567_1	765912.Thimo_3296	7.99e-55	186.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria,1WWCF@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3329,HATPase_c,HisKA,PAS,PAS_8
k59_189542_1	522306.CAP2UW1_1254	1.03e-54	176.0	COG3133@1|root,COG3133@2|Bacteria	2|Bacteria	M	Outer membrane lipoprotein	pcp	-	-	ko:K06077	-	-	-	-	ko00000	-	-	-	Rick_17kDa_Anti
k59_958215_1	593907.Celgi_0153	6.76e-70	214.0	COG1832@1|root,COG1832@2|Bacteria,2IJYY@201174|Actinobacteria	201174|Actinobacteria	S	PFAM CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
k59_1838569_1	156978.CIMIT_10510	1.83e-57	194.0	COG0280@1|root,COG0280@2|Bacteria,2GJ5U@201174|Actinobacteria,22JPM@1653|Corynebacteriaceae	201174|Actinobacteria	C	phosphate acetyltransferase	pta	GO:0005575,GO:0005576	2.3.1.8	ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,DRTGG,PTA_PTB
k59_541382_1	263358.VAB18032_14875	3.76e-17	82.4	COG0169@1|root,COG0169@2|Bacteria,2GPQQ@201174|Actinobacteria,4D8NH@85008|Micromonosporales	201174|Actinobacteria	E	Shikimate	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2552c	Shikimate_DH,Shikimate_dh_N
k59_541382_2	1284352.AOIG01000008_gene2407	5.33e-15	74.3	COG0476@1|root,COG0476@2|Bacteria,1TQ3U@1239|Firmicutes,4HBGP@91061|Bacilli,26QS0@186822|Paenibacillaceae	91061|Bacilli	H	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2	moeB1	-	2.7.7.73,2.7.7.80	ko:K03148,ko:K21029	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
k59_306327_1	330214.NIDE2454	5.91e-72	233.0	COG0114@1|root,COG0114@2|Bacteria,3J0FU@40117|Nitrospirae	40117|Nitrospirae	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_306327_2	680646.RMDY18_03260	2.57e-26	102.0	COG0757@1|root,COG0757@2|Bacteria,2IMBY@201174|Actinobacteria,1W969@1268|Micrococcaceae	201174|Actinobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
k59_1009001_1	56110.Oscil6304_3947	1.13e-14	79.7	COG2114@1|root,COG3437@1|root,COG2114@2|Bacteria,COG3437@2|Bacteria,1FZXP@1117|Cyanobacteria,1H9CI@1150|Oscillatoriales	1117|Cyanobacteria	T	Response regulator receiver domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,Response_reg
k59_1009001_2	439497.RR11_3014	6.59e-23	108.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2TRKK@28211|Alphaproteobacteria,4N9RB@97050|Ruegeria	28211|Alphaproteobacteria	M	Mechanosensitive ion channel	kefA	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	DUF3772,MS_channel
k59_1310381_1	566466.NOR53_2856	9.76e-39	145.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,1RMA1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	ABC-type oligopeptide transport system, periplasmic component	-	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
k59_1310381_2	278957.ABEA03000201_gene4325	7.15e-32	124.0	COG0444@1|root,COG4608@1|root,COG0444@2|Bacteria,COG4608@2|Bacteria,46U8E@74201|Verrucomicrobia,3KA26@414999|Opitutae	414999|Opitutae	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
k59_541383_1	388413.ALPR1_07945	5.18e-65	219.0	COG0642@1|root,COG2205@2|Bacteria,4NGAS@976|Bacteroidetes,47PB2@768503|Cytophagia	976|Bacteroidetes	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,TPR_8
k59_1657436_1	396588.Tgr7_2775	1.77e-102	301.0	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,1RNF8@1236|Gammaproteobacteria,1WVVE@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
k59_774064_1	944560.HMPREF9058_0726	6.37e-14	77.0	COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,4D3VV@85005|Actinomycetales	201174|Actinobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_834968_1	446466.Cfla_2182	5.21e-156	448.0	COG0423@1|root,COG0423@2|Bacteria,2GIT3@201174|Actinobacteria,4F0Q9@85016|Cellulomonadaceae	201174|Actinobacteria	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
k59_306336_1	2340.JV46_21780	2.67e-58	184.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S607@1236|Gammaproteobacteria,1J70E@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	hspA	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_1484501_1	909663.KI867150_gene375	5.55e-65	211.0	COG1349@1|root,COG1349@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	3.6.4.12	ko:K02444,ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	AlbA_2,DUF1670,DeoRC,HATPase_c_4,HTH_DeoR
k59_541391_1	1177181.T9A_00667	2.13e-67	216.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,1XI08@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
k59_1126584_1	266940.Krad_1866	6.53e-11	62.0	COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria	201174|Actinobacteria	O	AAA ATPase forming ring-shaped complexes	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
k59_1126584_2	590998.Celf_1790	4.73e-32	125.0	COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria,4F0J3@85016|Cellulomonadaceae	201174|Actinobacteria	S	Pup-ligase protein	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
k59_1484502_1	1121448.DGI_2643	1.76e-82	257.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,43EAS@68525|delta/epsilon subdivisions,2X7TI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_659234_2	1265502.KB905951_gene833	2.42e-46	153.0	COG3631@1|root,COG3631@2|Bacteria,1RHRD@1224|Proteobacteria,2VSXM@28216|Betaproteobacteria,4AENZ@80864|Comamonadaceae	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
k59_599647_1	439235.Dalk_1330	5.87e-27	108.0	COG3464@1|root,COG3464@2|Bacteria,1PFY7@1224|Proteobacteria,4377W@68525|delta/epsilon subdivisions,2X29U@28221|Deltaproteobacteria,2MP93@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Helix-turn-helix domain of transposase family ISL3	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3
k59_599647_2	439235.Dalk_1330	1.81e-42	149.0	COG3464@1|root,COG3464@2|Bacteria,1PFY7@1224|Proteobacteria,4377W@68525|delta/epsilon subdivisions,2X29U@28221|Deltaproteobacteria,2MP93@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Helix-turn-helix domain of transposase family ISL3	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3
k59_660043_1	1485544.JQKP01000001_gene1158	2.68e-97	299.0	COG2509@1|root,COG2509@2|Bacteria,1MV6P@1224|Proteobacteria,2VHGJ@28216|Betaproteobacteria,44V1K@713636|Nitrosomonadales	28216|Betaproteobacteria	S	fad dependent oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	Amino_oxidase,Pyr_redox_2
k59_1423438_1	1128421.JAGA01000003_gene3248	3.94e-20	93.6	COG0477@1|root,COG2814@2|Bacteria,2NQ08@2323|unclassified Bacteria	2|Bacteria	EGP	MFS_1 like family	-	-	-	ko:K08151,ko:K08153	-	M00668,M00717	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75,2.A.1.2.8	-	-	MFS_1,MFS_1_like,Sugar_tr
k59_959330_1	768671.ThimaDRAFT_0078	4.39e-49	165.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1WWR6@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator, LysR	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_959330_2	572477.Alvin_0437	0.000434	42.7	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1WWHQ@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_1598101_2	471856.Jden_0134	3.2e-61	200.0	COG1131@1|root,COG1131@2|Bacteria,2GNQJ@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_131748_1	187272.Mlg_1958	3.56e-136	399.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1WXM2@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_1598105_2	935839.JAGJ01000002_gene829	2.32e-21	89.4	COG3824@1|root,COG3824@2|Bacteria,2IS6W@201174|Actinobacteria,4F4JW@85017|Promicromonosporaceae	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
k59_1363794_2	1123504.JQKD01000021_gene5660	1.38e-56	188.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2VHBP@28216|Betaproteobacteria,4AASV@80864|Comamonadaceae	28216|Betaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_835776_1	570952.ATVH01000020_gene1005	4.82e-06	48.9	COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,2TSRR@28211|Alphaproteobacteria,2JPT5@204441|Rhodospirillales	204441|Rhodospirillales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs	dusA	-	-	ko:K05539	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_835776_2	1163617.SCD_n00825	2.42e-28	107.0	COG3308@1|root,COG3308@2|Bacteria,1N1EF@1224|Proteobacteria,2VU3C@28216|Betaproteobacteria	28216|Betaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2069
k59_1598107_2	765912.Thimo_1528	1.39e-125	365.0	COG1305@1|root,COG1305@2|Bacteria,1MVAG@1224|Proteobacteria,1RMXM@1236|Gammaproteobacteria,1X0QJ@135613|Chromatiales	135613|Chromatiales	E	Bacterial transglutaminase-like N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_1658285_1	717785.HYPMC_3867	7.39e-75	234.0	COG1236@1|root,COG1236@2|Bacteria,1MV7U@1224|Proteobacteria,2TQU5@28211|Alphaproteobacteria,3N649@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	exonuclease of the beta-lactamase fold involved in RNA processing	MA20_22065	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Lactamase_B
k59_1598120_1	864069.MicloDRAFT_00024070	2.91e-35	128.0	COG1802@1|root,COG1802@2|Bacteria,1R90Y@1224|Proteobacteria,2U6A9@28211|Alphaproteobacteria,1JR4S@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	PFAM regulatory protein GntR HTH	matR	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_483380_1	1142394.PSMK_26780	3.53e-39	149.0	COG0589@1|root,COG1808@1|root,COG0589@2|Bacteria,COG1808@2|Bacteria,2J3I1@203682|Planctomycetes	203682|Planctomycetes	T	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
k59_78541_1	321332.CYB_2654	1.23e-28	118.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1FZW6@1117|Cyanobacteria,1GZY9@1129|Synechococcus	1117|Cyanobacteria	S	protein conserved in bacteria	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
k59_600454_1	1123392.AQWL01000008_gene1250	9.88e-35	125.0	2DZRC@1|root,32VGV@2|Bacteria,1PWQA@1224|Proteobacteria,2WC8T@28216|Betaproteobacteria,1KT99@119069|Hydrogenophilales	119069|Hydrogenophilales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_489257_1	497964.CfE428DRAFT_6160	6.03e-26	100.0	COG1853@1|root,COG1853@2|Bacteria,46TTE@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
k59_1083899_1	765914.ThisiDRAFT_1295	1.2e-95	297.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WX5F@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_1429447_1	1396141.BATP01000022_gene395	7.16e-84	268.0	COG1621@1|root,COG2382@1|root,COG1621@2|Bacteria,COG2382@2|Bacteria,46U0H@74201|Verrucomicrobia,2IVDH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_1721794_1	543728.Vapar_1929	5.81e-76	237.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria,4ABQ6@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	wlbC	-	2.6.1.98	ko:K13017	ko00520,map00520	-	R10141	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
k59_489264_1	96561.Dole_0601	4.61e-65	213.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2WIK7@28221|Deltaproteobacteria,2MIHR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_489264_2	933262.AXAM01000010_gene1388	1.55e-82	253.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,42N8B@68525|delta/epsilon subdivisions,2WJ6I@28221|Deltaproteobacteria,2MIR3@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_547763_1	1121481.AUAS01000011_gene5113	1.02e-20	89.4	COG0350@1|root,COG2207@1|root,COG0350@2|Bacteria,COG2207@2|Bacteria,4NFYC@976|Bacteroidetes,47K38@768503|Cytophagia	976|Bacteroidetes	K	PFAM 6-O-methylguanine DNA methyltransferase, DNA binding domain	ada	-	2.1.1.63	ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	DNA_binding_1,HTH_18,Methyltransf_1N
k59_430457_1	1380354.JIAN01000006_gene878	1.8e-109	329.0	COG0366@1|root,COG0366@2|Bacteria,2GKK1@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	aml	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_20
k59_547772_1	1115512.EH105704_04_00560	5.83e-27	109.0	COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,1RP78@1236|Gammaproteobacteria,3XNE0@561|Escherichia	1236|Gammaproteobacteria	E	Belongs to the carbamate kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_1722768_1	582899.Hden_3220	6.42e-118	362.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2TQTQ@28211|Alphaproteobacteria,3N6EP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C
k59_1849610_2	1122604.JONR01000023_gene4191	7.8e-09	56.6	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,1X52H@135614|Xanthomonadales	135614|Xanthomonadales	E	Transporter	ygdR	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
k59_1849613_2	742743.HMPREF9453_01127	5.82e-10	58.9	COG0640@1|root,COG0640@2|Bacteria,1VEER@1239|Firmicutes,4H5ZG@909932|Negativicutes	909932|Negativicutes	K	Transcriptional regulator, ArsR family	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
k59_1085138_1	1304865.JAGF01000001_gene2970	2.88e-72	229.0	COG1273@1|root,COG1273@2|Bacteria,2GJMU@201174|Actinobacteria,4F20Y@85016|Cellulomonadaceae	201174|Actinobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050790,GO:0050896,GO:0051340,GO:0051351,GO:0051716,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
k59_1259378_1	1249627.D779_0893	1.14e-83	265.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1WWKE@135613|Chromatiales	135613|Chromatiales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_725260_1	243233.MCA2015	1.26e-143	418.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1XE7G@135618|Methylococcales	135618|Methylococcales	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
k59_725260_2	1163617.SCD_n01217	3.21e-32	115.0	COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,2VR9K@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
k59_88359_1	223926.28806209	4.89e-24	99.8	COG2863@1|root,COG2863@2|Bacteria,1R8K9@1224|Proteobacteria,1S1Q4@1236|Gammaproteobacteria,1XX4A@135623|Vibrionales	135623|Vibrionales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K17230	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001	-	-	-	Cytochrome_CBB3
k59_1665410_3	1144275.COCOR_03278	6.94e-40	143.0	COG3501@1|root,COG3501@2|Bacteria,1R540@1224|Proteobacteria,42Q1X@68525|delta/epsilon subdivisions,2WM75@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Baseplate assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_88361_1	351348.Maqu_1561	1.53e-25	113.0	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,4646P@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	COG3170 Tfp pilus assembly protein FimV	fimV	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	LysM,TPR_19
k59_1259382_1	1713.JOFV01000001_gene2022	2.23e-59	205.0	COG1512@1|root,COG1512@2|Bacteria,2GMGW@201174|Actinobacteria,4F0HG@85016|Cellulomonadaceae	201174|Actinobacteria	S	TPM domain	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	TPM_phosphatase
k59_1604813_1	1121918.ARWE01000001_gene1976	8.39e-10	64.7	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43ADB@68525|delta/epsilon subdivisions,2X5T7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HATPase_c,HisKA
k59_431438_1	1385519.N801_06655	4.3e-29	120.0	COG2197@1|root,COG2197@2|Bacteria,2GPKD@201174|Actinobacteria,4FHGZ@85021|Intrasporangiaceae	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
k59_910204_1	1267005.KB911257_gene1077	5.36e-67	228.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,3N63N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Alpha-2-Macroglobulin	MA20_30110	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,PAN_1,Thiol-ester_cl
k59_666799_1	471853.Bcav_3818	0.0	1011.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,2GIT4@201174|Actinobacteria	201174|Actinobacteria	CP	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit	mrpA/mrpB	-	-	ko:K05565,ko:K14086	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
k59_1370722_1	1123065.ATWL01000008_gene2527	1.75e-90	283.0	COG0366@1|root,COG0366@2|Bacteria,2GIV1@201174|Actinobacteria	201174|Actinobacteria	G	trehalose synthase	treS	GO:0000023,GO:0000271,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016160,GO:0016161,GO:0016787,GO:0016798,GO:0016853,GO:0016866,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046872,GO:0047471,GO:0055114,GO:0071704,GO:0071944,GO:1901576	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	iNJ661.Rv0126	Alpha-amylase,Malt_amylase_C
k59_490271_1	1121019.AUMN01000002_gene170	7.8e-31	120.0	COG3424@1|root,COG3424@2|Bacteria,2GV0U@201174|Actinobacteria,1W7QY@1268|Micrococcaceae	201174|Actinobacteria	Q	Chalcone and stilbene synthases, N-terminal domain	-	-	-	ko:K16167	-	-	-	-	ko00000,ko01008	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
k59_33398_1	269797.Mbar_A1367	1.87e-37	134.0	COG0521@1|root,arCOG00214@2157|Archaea,2XWJF@28890|Euryarchaeota,2N9SU@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM molybdenum cofactor synthesis domain	moaB	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
k59_969201_1	713586.KB900536_gene1719	4.54e-66	204.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_267070_2	232721.Ajs_1912	1.39e-120	363.0	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,2VHSF@28216|Betaproteobacteria,4AD81@80864|Comamonadaceae	28216|Betaproteobacteria	C	Cytochrome D1 heme domain	nirS	-	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
k59_1321457_1	1049564.TevJSym_ba00350	2.92e-132	401.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J595@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	cation transport ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_197158_2	479431.Namu_3219	2.56e-20	88.2	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,SnoaL
k59_381932_1	765910.MARPU_05395	7.69e-71	228.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WXWZ@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1321459_1	237727.NAP1_14038	2.09e-116	341.0	COG3186@1|root,COG3186@2|Bacteria,1MU29@1224|Proteobacteria,2TU1E@28211|Alphaproteobacteria,2K01F@204457|Sphingomonadales	204457|Sphingomonadales	E	Phenylalanine-4-hydroxylase	phhA	-	1.14.16.1	ko:K00500	ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230	-	R01795,R07211	RC00490	ko00000,ko00001,ko01000	-	-	-	Biopterin_H
k59_33421_1	378806.STAUR_0742	6.75e-22	93.6	COG0500@1|root,COG2226@2|Bacteria,1RFPW@1224|Proteobacteria	1224|Proteobacteria	Q	Methyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_33421_2	631454.N177_3874	0.000293	45.4	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2TRU8@28211|Alphaproteobacteria,1JN95@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF853)	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
k59_607536_1	1380370.JIBA01000012_gene3406	2.37e-65	213.0	COG0477@1|root,COG0477@2|Bacteria,2GK8M@201174|Actinobacteria,4FG58@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_910229_1	1038862.KB893866_gene5181	4.08e-10	66.6	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Trans_reg_C
k59_1259405_1	1192034.CAP_6065	4.04e-91	295.0	COG1061@1|root,COG3886@1|root,COG1061@2|Bacteria,COG3886@2|Bacteria,1MV9F@1224|Proteobacteria,42NS1@68525|delta/epsilon subdivisions,2WQXY@28221|Deltaproteobacteria,2YWZQ@29|Myxococcales	28221|Deltaproteobacteria	KL	Domain of unknown function (DUF3427)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3427,Helicase_C,PLDc_2,ResIII
k59_969228_1	697282.Mettu_0405	4.26e-139	426.0	COG3459@1|root,COG3459@2|Bacteria,1R1HB@1224|Proteobacteria,1T531@1236|Gammaproteobacteria,1XG0G@135618|Methylococcales	135618|Methylococcales	G	Glycosyltransferase 36 associated	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_490290_1	765914.ThisiDRAFT_1546	4.11e-89	270.0	COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,1RRR0@1236|Gammaproteobacteria,1WY0S@135613|Chromatiales	135613|Chromatiales	O	PFAM 20S proteasome, A and B subunits	-	-	-	ko:K07395	-	-	-	-	ko00000	-	-	-	Proteasome
k59_910242_1	314292.VAS14_18986	8.19e-16	70.9	COG4327@1|root,COG4327@2|Bacteria,1N0TK@1224|Proteobacteria,1S8V9@1236|Gammaproteobacteria,1XXSA@135623|Vibrionales	135623|Vibrionales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF4212
k59_1430569_1	765911.Thivi_0273	1.36e-88	284.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1WWSC@135613|Chromatiales	135613|Chromatiales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_1665444_1	439235.Dalk_0360	2.51e-12	68.2	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,42N6U@68525|delta/epsilon subdivisions,2WQ3X@28221|Deltaproteobacteria,2MK0N@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lipid A biosynthesis	htrB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_381953_1	981384.AEYW01000028_gene4248	1.57e-40	149.0	2F138@1|root,33U4R@2|Bacteria,1NUMP@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_381959_1	1231190.NA8A_20257	8.68e-35	128.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,43IEJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent	TP53I	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_381959_2	1126627.BAWE01000002_gene792	3.26e-57	185.0	COG0500@1|root,COG0500@2|Bacteria,1REJ2@1224|Proteobacteria,2U7T5@28211|Alphaproteobacteria,3JV3K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
k59_910250_1	1304865.JAGF01000001_gene683	2.77e-82	269.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2GKI9@201174|Actinobacteria,4F0N4@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8
k59_197175_2	590998.Celf_1600	2.79e-15	75.5	COG0421@1|root,COG0421@2|Bacteria,2GN8I@201174|Actinobacteria,4F2AK@85016|Cellulomonadaceae	201174|Actinobacteria	E	spermidine synthase	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Spermine_synth
k59_1085192_1	289376.THEYE_A1945	8.5e-82	255.0	COG0191@1|root,COG0191@2|Bacteria,3J0WJ@40117|Nitrospirae	40117|Nitrospirae	G	Fructose-bisphosphate aldolase class-II	-	-	-	-	-	-	-	-	-	-	-	-	F_bP_aldolase
k59_969251_1	519989.ECTPHS_13218	2.33e-148	456.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_1259428_1	1515746.HR45_10110	1.02e-22	98.2	COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,1RRWT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_1321500_1	471853.Bcav_2735	6.19e-91	290.0	COG2352@1|root,COG2352@2|Bacteria,2GKDB@201174|Actinobacteria	201174|Actinobacteria	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
k59_1604851_1	405948.SACE_7323	2.1e-19	92.4	COG0477@1|root,COG2814@2|Bacteria,2H32P@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1665460_1	1209072.ALBT01000066_gene1094	8.2e-48	165.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1FGDP@10|Cellvibrio	1236|Gammaproteobacteria	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
k59_969265_1	479434.Sthe_3014	7.78e-27	113.0	COG0281@1|root,COG0281@2|Bacteria,2G65R@200795|Chloroflexi,27XFK@189775|Thermomicrobia	189775|Thermomicrobia	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
k59_548887_1	1286106.MPL1_06270	6.36e-112	333.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,45ZSD@72273|Thiotrichales	72273|Thiotrichales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_138599_1	443143.GM18_3178	0.000185	44.3	COG0454@1|root,COG0456@2|Bacteria,1RF31@1224|Proteobacteria,42RUB@68525|delta/epsilon subdivisions,2WN97@28221|Deltaproteobacteria,43UM1@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_138599_2	589865.DaAHT2_0209	7.53e-49	173.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,43BFP@68525|delta/epsilon subdivisions,2X6U3@28221|Deltaproteobacteria,2MPIH@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Peptidase dimerisation domain	-	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
k59_1321523_1	450851.PHZ_c0446	7.86e-76	248.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,2KFS8@204458|Caulobacterales	204458|Caulobacterales	M	gamma-glutamyltransferase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_197189_1	29581.BW37_03349	5.62e-18	85.1	COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,2VH5R@28216|Betaproteobacteria,472DD@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	protease with the C-terminal PDZ	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
k59_1195566_1	935845.JADQ01000008_gene1849	3.09e-23	107.0	COG3857@1|root,COG3857@2|Bacteria,1TQJW@1239|Firmicutes,4HAY6@91061|Bacilli,26QFV@186822|Paenibacillaceae	91061|Bacilli	L	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation	rexB	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0004527,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
k59_314452_1	670307.HYPDE_31943	1.39e-138	400.0	COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria,2TRRQ@28211|Alphaproteobacteria,3N7UK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Saccharopine dehydrogenase C-terminal domain	lys1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_33514_1	335543.Sfum_0207	1.43e-11	67.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,2MR8Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NADH-Ubiquinone oxidoreductase (complex I), chain 5	nuoL-2	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
k59_33514_2	880072.Desac_1207	8e-40	134.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,42UWR@68525|delta/epsilon subdivisions,2WQRB@28221|Deltaproteobacteria,2MQNF@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
k59_1665478_1	575540.Isop_0993	1.38e-24	108.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXDF@203682|Planctomycetes	575540.Isop_0993|-	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
k59_1370776_1	1249627.D779_2196	3.71e-116	341.0	28I2K@1|root,2Z86N@2|Bacteria,1R1GA@1224|Proteobacteria,1RRPU@1236|Gammaproteobacteria,1WXHU@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_138605_1	1246484.D479_09285	6.7e-74	242.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,4HAB8@91061|Bacilli,3NDPE@45667|Halobacillus	91061|Bacilli	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_1493915_1	1223521.BBJX01000002_gene2673	4.91e-213	597.0	COG0446@1|root,COG0446@2|Bacteria,1PP77@1224|Proteobacteria,2W9FF@28216|Betaproteobacteria,4AA7E@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_1849749_1	396588.Tgr7_0189	1.23e-72	226.0	COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,1S739@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
k59_1195574_1	593907.Celgi_2377	7.71e-133	392.0	COG0119@1|root,COG0119@2|Bacteria,2GKYT@201174|Actinobacteria,4F102@85016|Cellulomonadaceae	201174|Actinobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA2	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1370779_1	2340.JV46_02810	2.13e-110	329.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,1J5JA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
k59_784383_1	102129.Lepto7375DRAFT_0663	6.63e-17	80.9	COG3547@1|root,COG3547@2|Bacteria,1G077@1117|Cyanobacteria,1H97S@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1434971_1	1379270.AUXF01000001_gene2437	0.000401	47.8	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,1ZUTN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_8
k59_494633_1	177439.DP1198	2.46e-81	251.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NK7@68525|delta/epsilon subdivisions,2WKTV@28221|Deltaproteobacteria,2MMQF@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,ELFV_dehydrog,ELFV_dehydrog_N
k59_847099_1	765914.ThisiDRAFT_2315	1.36e-62	219.0	COG0187@1|root,COG1372@1|root,COG0187@2|Bacteria,COG1372@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1WVZ4@135613|Chromatiales	135613|Chromatiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_96329_1	886293.Sinac_5378	1.26e-15	79.7	COG0584@1|root,COG0584@2|Bacteria,2IZ1A@203682|Planctomycetes	203682|Planctomycetes	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
k59_1857686_2	667014.Thein_0928	6.82e-51	170.0	COG1525@1|root,COG2169@1|root,COG1525@2|Bacteria,COG2169@2|Bacteria,2GHU7@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	Staphylococcal nuclease homologues	-	-	-	-	-	-	-	-	-	-	-	-	Ada_Zn_binding,SNase
k59_1264352_1	305700.B447_00560	3.4e-16	77.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VJD9@28216|Betaproteobacteria,2KUGV@206389|Rhodocyclales	206389|Rhodocyclales	C	radical SAM protein	nirJ	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
k59_1264352_2	981384.AEYW01000022_gene3669	6.08e-66	206.0	COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,2U84D@28211|Alphaproteobacteria,4NBXD@97050|Ruegeria	28211|Alphaproteobacteria	K	AsnC-type helix-turn-helix domain	nirH	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
k59_1264352_3	571166.KI421509_gene3317	1.92e-13	66.6	COG1522@1|root,COG1522@2|Bacteria,1RIKY@1224|Proteobacteria,2U81N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG1522 Transcriptional regulators	nirG	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
k59_1727319_1	948565.AFFP02000002_gene1332	2.29e-50	177.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1Y6ZZ@135625|Pasteurellales	135625|Pasteurellales	L	it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction	rep	-	3.6.4.12	ko:K03656,ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_39926_1	177437.HRM2_47440	2.31e-74	248.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WISW@28221|Deltaproteobacteria,2MIUG@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_611960_1	1452535.JARD01000020_gene1255	1.02e-17	83.2	COG1280@1|root,COG1280@2|Bacteria,2HRC6@201174|Actinobacteria,4FMTC@85023|Microbacteriaceae	201174|Actinobacteria	E	Sap, sulfolipid-1-addressing protein	-	-	-	-	-	-	-	-	-	-	-	-	SfLAP
k59_39927_1	391165.GbCGDNIH1_0793	4.42e-22	90.9	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U6Z6@28211|Alphaproteobacteria,2JSHT@204441|Rhodospirillales	204441|Rhodospirillales	C	[2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2,Fer2_2
k59_39927_2	504472.Slin_1104	5.62e-11	65.9	COG1529@1|root,COG1529@2|Bacteria,4NFFU@976|Bacteroidetes,47KVI@768503|Cytophagia	976|Bacteroidetes	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
k59_1727322_1	1158146.KB907121_gene1142	5.16e-20	85.9	COG1416@1|root,COG1416@2|Bacteria,1MZ46@1224|Proteobacteria,1SNE5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DsrE/DsrF-like family	-	-	-	ko:K09004	-	-	-	-	ko00000	-	-	-	DrsE
k59_1727322_2	316067.Geob_0406	8.63e-34	135.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,42MV3@68525|delta/epsilon subdivisions,2WJZB@28221|Deltaproteobacteria,43SX6@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	DEAD DEAH box helicase domain protein	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
k59_39928_1	1121396.KB893101_gene487	9.48e-55	195.0	COG1480@1|root,COG1480@2|Bacteria,1NCY5@1224|Proteobacteria,42MI9@68525|delta/epsilon subdivisions,2WJI1@28221|Deltaproteobacteria,2MI01@213118|Desulfobacterales	28221|Deltaproteobacteria	S	metal-dependent phosphohydrolase 7TM intracellular region	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
k59_273220_1	95619.PM1_0218165	7.12e-21	91.3	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iUTI89_1310.UTI89_C0210	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
k59_273220_2	526227.Mesil_2142	7.26e-70	223.0	COG0059@1|root,COG0059@2|Bacteria,1WIFD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
k59_671123_2	748658.KB907317_gene311	6.01e-42	144.0	COG1886@1|root,COG1886@2|Bacteria,1RGWT@1224|Proteobacteria,1S5YE@1236|Gammaproteobacteria,1WYIG@135613|Chromatiales	135613|Chromatiales	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	-	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
k59_671123_3	754477.Q7C_1254	2.09e-47	164.0	COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,1RQ8M@1236|Gammaproteobacteria,45ZXB@72273|Thiotrichales	72273|Thiotrichales	N	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	-	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
k59_96369_1	1122611.KB903996_gene7529	1.29e-24	106.0	COG0477@1|root,COG2814@2|Bacteria,2I2JA@201174|Actinobacteria,4ER83@85012|Streptosporangiales	201174|Actinobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_1785036_1	96561.Dole_1991	8.28e-08	60.1	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,42MN4@68525|delta/epsilon subdivisions,2WJJ5@28221|Deltaproteobacteria,2MHRG@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Belongs to the GPAT DAPAT family	plsB	-	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_611973_1	626887.J057_08011	5.3e-40	144.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,465CG@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
k59_389838_1	158822.LH89_18525	5.75e-20	88.6	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.200	ko:K02533,ko:K15396	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
k59_389838_2	910964.GEAM_0645	8.86e-177	504.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	GO:0001522,GO:0003674,GO:0003824,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016769,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	iPC815.YPO2896,iYL1228.KPN_02862	Aminotran_5
k59_39941_1	234267.Acid_1319	2.64e-49	171.0	COG3547@1|root,COG3547@2|Bacteria,3Y52I@57723|Acidobacteria	57723|Acidobacteria	L	transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1137782_2	1144312.PMI09_03066	2.54e-23	101.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,4BA7G@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	ABC transporter transmembrane region	msbA2	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_1857740_1	1110502.TMO_3028	1.29e-107	323.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria,2JPW2@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_1329463_2	1123393.KB891316_gene1617	4.78e-09	55.8	COG0607@1|root,COG0607@2|Bacteria,1RJQ6@1224|Proteobacteria	1224|Proteobacteria	P	COG0607 Rhodanese-related sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_1019328_1	1385521.N803_13385	2.88e-46	159.0	COG4760@1|root,COG4760@2|Bacteria,2GNCK@201174|Actinobacteria,4FFKN@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	BaxI_1
k59_39950_1	936573.HMPREF1147_1582	8.56e-79	244.0	COG3039@1|root,COG3039@2|Bacteria,1UEG7@1239|Firmicutes,4H5CB@909932|Negativicutes	909932|Negativicutes	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_273245_1	926569.ANT_00490	1.54e-59	201.0	COG0433@1|root,COG0433@2|Bacteria,2G62A@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function DUF87	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
k59_977271_1	768671.ThimaDRAFT_1821	3.94e-67	222.0	COG1680@1|root,COG1680@2|Bacteria,1PGQT@1224|Proteobacteria,1SWR7@1236|Gammaproteobacteria,1X19R@135613|Chromatiales	135613|Chromatiales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k59_1329494_2	1247726.MIM_c24570	2.42e-16	77.4	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2VHHV@28216|Betaproteobacteria,3T1HD@506|Alcaligenaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_142926_1	247490.KSU1_C0392	1.83e-102	319.0	COG0466@1|root,COG0466@2|Bacteria,2IYNA@203682|Planctomycetes	203682|Planctomycetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_1435020_1	1121013.P873_04475	7.64e-104	322.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,1RQ01@1236|Gammaproteobacteria,1X4DX@135614|Xanthomonadales	135614|Xanthomonadales	P	Nitric oxide reductase large subunit	-	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
k59_1329495_1	159087.Daro_2602	7.97e-88	268.0	COG3221@1|root,COG3221@2|Bacteria,1QJET@1224|Proteobacteria,2VIVQ@28216|Betaproteobacteria,2KUCY@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
k59_273254_1	1121405.dsmv_2938	2.78e-89	281.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,42P5R@68525|delta/epsilon subdivisions,2WJDU@28221|Deltaproteobacteria,2MI4P@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_977282_1	1116369.KB890024_gene549	7.3e-42	151.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2TUH6@28211|Alphaproteobacteria,43IQK@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Sulfate transporter	MA20_05210	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k59_494691_1	1234364.AMSF01000016_gene1503	7.54e-179	521.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RPSW@1236|Gammaproteobacteria,1X5RU@135614|Xanthomonadales	135614|Xanthomonadales	G	COG3957 Phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
k59_1727362_1	1282887.AUJG01000003_gene483	1.22e-05	50.4	COG4641@1|root,COG4641@2|Bacteria	2|Bacteria	M	Protein conserved in bacteria	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	DUF3880,Glyco_trans_1_2,Glycos_transf_2
k59_1857784_1	471853.Bcav_1207	1.39e-55	197.0	COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_273261_1	1208323.B30_15286	1.74e-08	55.8	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2TR2Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC transporter	hndI	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_273261_2	936455.KI421499_gene486	3.72e-66	208.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2TQSY@28211|Alphaproteobacteria,3JRRG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	transport, permease protein	yadH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_1857796_1	671143.DAMO_0966	9.26e-80	248.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2NPE1@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M50	spoIVFB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K06212,ko:K06402	-	-	-	-	ko00000,ko01000,ko01002,ko02000	1.A.16.1.1,1.A.16.1.3	-	-	CBS,Form_Nir_trans,Peptidase_M50
k59_1498848_1	471857.Svir_29090	4.17e-34	121.0	COG1225@1|root,COG1225@2|Bacteria,2IHZ6@201174|Actinobacteria,4E2TH@85010|Pseudonocardiales	201174|Actinobacteria	O	PFAM AhpC TSA family	bcp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_435929_1	96561.Dole_1461	4.13e-100	310.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MINQ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
k59_273264_1	997350.HMPREF9129_0714	1.48e-35	127.0	COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,24HAJ@186801|Clostridia,22HCT@1570339|Peptoniphilaceae	186801|Clostridia	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
k59_273264_2	887929.HMP0721_1493	8.21e-13	63.2	COG1841@1|root,COG1841@2|Bacteria,1VEG4@1239|Firmicutes,24QKC@186801|Clostridia,25X9Q@186806|Eubacteriaceae	186801|Clostridia	J	COG1841 Ribosomal protein L30 L7E	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
k59_1857801_1	1121430.JMLG01000001_gene2240	5.05e-23	100.0	COG0751@1|root,COG0751@2|Bacteria,1TNZ7@1239|Firmicutes,248RS@186801|Clostridia,2608I@186807|Peptococcaceae	186801|Clostridia	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_1857801_2	768670.Calni_0744	3.49e-88	266.0	COG0752@1|root,COG0752@2|Bacteria,2GEZ4@200930|Deferribacteres	200930|Deferribacteres	J	Glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
k59_1199957_1	196627.cg1767	4.59e-16	77.8	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,22JMG@1653|Corynebacteriaceae	201174|Actinobacteria	V	ABC transporter, ATP-binding protein	drrA_2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1199957_2	1121385.AQXW01000004_gene1218	1.3e-09	60.1	COG2345@1|root,COG2345@2|Bacteria,2GN8W@201174|Actinobacteria,1ZVYP@145357|Dermacoccaceae	201174|Actinobacteria	K	transcriptional regulator	sufR	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_20,HTH_24,HTH_5,MarR_2
k59_494708_1	335543.Sfum_3131	8.69e-89	265.0	COG4656@1|root,COG4656@2|Bacteria,1MWAX@1224|Proteobacteria,42NJM@68525|delta/epsilon subdivisions,2WJJB@28221|Deltaproteobacteria,2MRCN@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Methylene-tetrahydrofolate reductase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR_C
k59_847173_2	863365.XHC_4424	2.37e-24	102.0	COG1595@1|root,COG1595@2|Bacteria,1N6SV@1224|Proteobacteria,1S570@1236|Gammaproteobacteria,1X6UZ@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_142946_1	67352.JODS01000009_gene7519	7.58e-46	152.0	COG0009@1|root,COG0009@2|Bacteria,2GNEW@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the SUA5 family	-	-	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
k59_142946_2	105425.BBPL01000063_gene5279	1.03e-40	147.0	COG1277@1|root,COG1277@2|Bacteria,2ID14@201174|Actinobacteria	201174|Actinobacteria	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
k59_1435737_2	292415.Tbd_0944	7.36e-34	120.0	COG3094@1|root,COG3094@2|Bacteria,1MZN6@1224|Proteobacteria,2VUWN@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Invasion gene expression up-regulator SirB	sirB	-	-	-	-	-	-	-	-	-	-	-	SirB
k59_1551513_1	748247.AZKH_0152	1.41e-52	173.0	COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,2VJ6G@28216|Betaproteobacteria,2KW7N@206389|Rhodocyclales	206389|Rhodocyclales	S	Carboxylesterase	estB	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
k59_391178_1	1435356.Y013_15125	9.6e-48	161.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria,4FVPZ@85025|Nocardiaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_143659_1	1280947.HY30_11520	1.99e-40	153.0	COG2855@1|root,COG2855@2|Bacteria,1MVIP@1224|Proteobacteria,2TVK9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	membrane	yeiH	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
k59_143659_2	1121930.AQXG01000005_gene610	1.42e-05	46.6	COG0217@1|root,COG0217@2|Bacteria,4NE8Y@976|Bacteroidetes,1IQCX@117747|Sphingobacteriia	976|Bacteroidetes	K	transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
k59_1265218_1	887898.HMPREF0551_1880	9.97e-06	47.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,2VHC6@28216|Betaproteobacteria,1K28M@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Belongs to the ALAD family	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_1265218_2	626887.J057_08096	2.14e-68	219.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,4647Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_3165,iECOK1_1307.ECOK1_3701,iECS88_1305.ECS88_3669,iECUMN_1333.ECUMN_3755,iSBO_1134.SBO_3275,iUMN146_1321.UM146_16315,iUTI89_1310.UTI89_C3726	Shikimate_DH,Shikimate_dh_N
k59_1435740_1	1276756.AUEX01000006_gene3121	1.18e-45	159.0	COG2962@1|root,COG2962@2|Bacteria,1MX5G@1224|Proteobacteria,2VJ5U@28216|Betaproteobacteria	28216|Betaproteobacteria	S	RarD protein, DMT superfamily transporter	rarD	-	-	ko:K05786	-	-	-	-	ko00000,ko02000	2.A.7.7	-	-	EamA
k59_1200654_1	1005058.UMN179_01501	1.74e-08	59.7	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RR6K@1236|Gammaproteobacteria,1Y76Z@135625|Pasteurellales	135625|Pasteurellales	M	ADP-heptose LPS heptosyltransferase	opsX	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K12982	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_1200654_2	1500890.JQNL01000001_gene2465	3.81e-82	257.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,1X3W9@135614|Xanthomonadales	135614|Xanthomonadales	M	Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A)	lpxL	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
k59_671903_1	1172188.KB911825_gene3539	1.05e-13	75.9	2F8QP@1|root,3412Y@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_202223_1	582899.Hden_0310	1.7e-86	264.0	COG1988@1|root,COG3170@1|root,COG1988@2|Bacteria,COG3170@2|Bacteria,1MZEI@1224|Proteobacteria,2UEUZ@28211|Alphaproteobacteria,3N8E2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	NU	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	YdjM
k59_1499656_1	293826.Amet_4099	2.02e-05	50.4	COG3383@1|root,COG3383@2|Bacteria,1UI1F@1239|Firmicutes,25EAG@186801|Clostridia,36GS7@31979|Clostridiaceae	186801|Clostridia	C	Molybdopterin oxidoreductase Fe4S4 domain	fdhA2	-	1.17.1.11,1.17.1.9	ko:K00123,ko:K22341	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1859115_1	1232410.KI421426_gene1487	3.48e-118	354.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,42N30@68525|delta/epsilon subdivisions,2WJSW@28221|Deltaproteobacteria,43T0A@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Pyruvate kinase, barrel domain	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_274117_1	471853.Bcav_1305	1.76e-121	361.0	COG0056@1|root,COG0056@2|Bacteria,2GJRJ@201174|Actinobacteria	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_847873_1	439235.Dalk_3446	3.27e-35	133.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2WJ5B@28221|Deltaproteobacteria,2MHVD@213118|Desulfobacterales	28221|Deltaproteobacteria	J	TIGRFAM glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C
k59_1785700_1	644282.Deba_2699	2.07e-28	111.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WPKC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
k59_1859128_1	1123400.KB904746_gene1198	1.16e-111	326.0	COG0678@1|root,COG0695@1|root,COG0678@2|Bacteria,COG0695@2|Bacteria,1MU0H@1224|Proteobacteria,1RRFB@1236|Gammaproteobacteria,45ZZT@72273|Thiotrichales	72273|Thiotrichales	O	Glutaredoxin	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	Glutaredoxin,Redoxin
k59_978660_1	1278073.MYSTI_05195	1.44e-14	78.6	COG1480@1|root,COG1480@2|Bacteria,1NCY5@1224|Proteobacteria,42MI9@68525|delta/epsilon subdivisions,2WJI1@28221|Deltaproteobacteria,2YUW7@29|Myxococcales	28221|Deltaproteobacteria	S	7TM receptor with intracellular HD hydrolase	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
k59_143676_1	263358.VAB18032_16300	9.4e-94	288.0	COG2211@1|root,COG2211@2|Bacteria,2HD4Y@201174|Actinobacteria,4DC6A@85008|Micromonosporales	201174|Actinobacteria	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
k59_143676_2	1122933.JNIY01000003_gene205	8.37e-18	82.0	COG0300@1|root,COG0300@2|Bacteria,2I9BH@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_391215_1	187272.Mlg_0923	4.28e-162	482.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1WXK8@135613|Chromatiales	135613|Chromatiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_398171_3	710111.FraQA3DRAFT_5904	1.1e-47	162.0	COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,4ETG1@85013|Frankiales	201174|Actinobacteria	GK	PFAM ROK family	ppgK	-	2.7.1.2,2.7.1.63	ko:K00845,ko:K00886	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786,R02187,R02189	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
k59_1095695_2	85643.Tmz1t_0227	4.06e-85	259.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2VIT4@28216|Betaproteobacteria,2KUNU@206389|Rhodocyclales	206389|Rhodocyclales	K	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_440941_1	1120950.KB892708_gene4544	3.07e-99	299.0	COG1396@1|root,COG2856@1|root,COG1396@2|Bacteria,COG2856@2|Bacteria,2IEJJ@201174|Actinobacteria,4DTB1@85009|Propionibacteriales	201174|Actinobacteria	EK	IrrE N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,Peptidase_M78
k59_46782_1	160492.XF_2397	7.2e-40	148.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1X5EZ@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC transporter transmembrane region	hlyB	-	-	ko:K11004	ko02010,ko03070,ko05133,map02010,map03070,map05133	M00325,M00575	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.1,3.A.1.109.2	-	-	ABC_membrane,ABC_tran,Peptidase_C39
k59_1337912_1	335543.Sfum_0169	2.6e-68	218.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,42M1K@68525|delta/epsilon subdivisions,2WJ8E@28221|Deltaproteobacteria,2MR2W@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Creatinase/Prolidase N-terminal domain	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
k59_1732224_3	765913.ThidrDRAFT_1682	5.34e-23	95.5	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,1S64Q@1236|Gammaproteobacteria,1WWVF@135613|Chromatiales	135613|Chromatiales	S	Competence protein	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
k59_1613926_1	391735.Veis_2259	6.47e-10	57.8	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,2VKUA@28216|Betaproteobacteria,4AB50@80864|Comamonadaceae	28216|Betaproteobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
k59_1613926_2	1249627.D779_3348	9.54e-81	241.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,1S22R@1236|Gammaproteobacteria,1WXZD@135613|Chromatiales	135613|Chromatiales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_499648_1	1121405.dsmv_3246	1.43e-61	207.0	COG0472@1|root,COG1086@1|root,COG0472@2|Bacteria,COG1086@2|Bacteria,1MWYW@1224|Proteobacteria,42NVY@68525|delta/epsilon subdivisions,2X5IH@28221|Deltaproteobacteria,2MQ3P@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	CoA_binding_3,Glycos_transf_4
k59_1674872_1	1269813.ATUL01000003_gene2408	1.69e-49	178.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1WXPW@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
k59_1141939_2	595460.RRSWK_06362	1.46e-09	60.1	COG1595@1|root,COG1595@2|Bacteria,2IZXS@203682|Planctomycetes	203682|Planctomycetes	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
k59_1204825_1	440512.C211_10453	6.78e-30	113.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_558188_1	706587.Desti_0428	4.74e-09	57.4	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,42RIQ@68525|delta/epsilon subdivisions,2WNC7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM PEBP family protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
k59_558188_2	1195236.CTER_3096	4.14e-43	153.0	COG2227@1|root,COG2227@2|Bacteria,1UXZZ@1239|Firmicutes,24BIT@186801|Clostridia	186801|Clostridia	H	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
k59_851991_1	765912.Thimo_2084	1.35e-177	509.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWMG@135613|Chromatiales	135613|Chromatiales	L	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_616835_1	452637.Oter_0943	2.7e-59	195.0	COG0513@1|root,COG0513@2|Bacteria,46S5M@74201|Verrucomicrobia,3K7N6@414999|Opitutae	414999|Opitutae	L	helicase superfamily c-terminal domain	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
k59_1095729_3	457398.HMPREF0326_02904	4.33e-10	57.0	2D4ET@1|root,32TGZ@2|Bacteria,1RKAR@1224|Proteobacteria,42SQJ@68525|delta/epsilon subdivisions,2WP2T@28221|Deltaproteobacteria,2MC9S@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1555740_1	1096930.L284_03450	5.75e-21	93.6	COG4566@1|root,COG4566@2|Bacteria,1R47Z@1224|Proteobacteria,2TSQS@28211|Alphaproteobacteria,2K3TI@204457|Sphingomonadales	204457|Sphingomonadales	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_106331_2	1123367.C666_11825	6.61e-44	160.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,2KUGU@206389|Rhodocyclales	206389|Rhodocyclales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k59_1271292_1	1532557.JL37_22315	3.16e-65	226.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria	28216|Betaproteobacteria	M	mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
k59_677350_1	425104.Ssed_3909	6.4e-22	94.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,2Q8HF@267890|Shewanellaceae	1236|Gammaproteobacteria	V	PFAM ABC transporter related	yadG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_677350_2	1279019.ARQK01000060_gene2294	3.27e-44	150.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1WW0K@135613|Chromatiales	135613|Chromatiales	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_106333_1	1123502.AQXD01000002_gene301	5.3e-39	138.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1X3Y1@135614|Xanthomonadales	135614|Xanthomonadales	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_106333_2	478741.JAFS01000002_gene854	3.89e-10	61.2	COG0686@1|root,COG0686@2|Bacteria,46S7U@74201|Verrucomicrobia,37GD7@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	Alanine dehydrogenase/PNT, N-terminal domain	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_1096870_1	626887.J057_03295	2.73e-41	144.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,466TU@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	dsbC	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
k59_1096870_2	314278.NB231_14188	8.81e-60	185.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,1S5ZK@1236|Gammaproteobacteria,1X0ZV@135613|Chromatiales	135613|Chromatiales	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	-	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4
k59_48536_1	396588.Tgr7_1266	4.68e-136	401.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,1WWEA@135613|Chromatiales	135613|Chromatiales	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k59_207595_1	1247726.MIM_c09960	9.89e-06	48.9	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VHA3@28216|Betaproteobacteria,3T7XI@506|Alcaligenaceae	28216|Betaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k59_207595_2	1282361.ABAC402_10790	4.21e-09	60.8	COG3637@1|root,COG3637@2|Bacteria,1QYQM@1224|Proteobacteria,2UC29@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
k59_1505649_1	553385.JEMF01000074_gene1360	1.1e-27	103.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1XJ5P@135619|Oceanospirillales	135619|Oceanospirillales	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
k59_1505649_2	519989.ECTPHS_04244	1.66e-32	115.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,1WYPW@135613|Chromatiales	135613|Chromatiales	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
k59_441963_1	490899.DKAM_0631	5.57e-37	141.0	COG0574@1|root,arCOG01111@2157|Archaea,2XPWQ@28889|Crenarchaeota	28889|Crenarchaeota	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1505650_1	367299.JOEE01000001_gene2061	2e-29	116.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4FF3X@85021|Intrasporangiaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_1505650_2	367299.JOEE01000001_gene2060	1.84e-83	261.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4FFDF@85021|Intrasporangiaceae	201174|Actinobacteria	C	NADH ubiquinone oxidoreductase subunit	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_677358_1	1125863.JAFN01000001_gene2735	0.000218	48.9	COG3577@1|root,COG3577@2|Bacteria,1N8CA@1224|Proteobacteria	1224|Proteobacteria	S	gag-polyprotein putative aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,TPR_19,gag-asp_proteas
k59_1024264_2	498211.CJA_1776	8.22e-20	85.5	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1FG57@10|Cellvibrio	1236|Gammaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of	lolD	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051234,GO:0051641,GO:0055085,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0097159,GO:0097367,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1990778	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
k59_441967_2	326297.Sama_3326	1.2e-39	136.0	2E4R1@1|root,32ZJK@2|Bacteria,1N8FZ@1224|Proteobacteria,1S42H@1236|Gammaproteobacteria,2QEMH@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Nitrous oxide-stimulated promoter	ygbA	-	-	-	-	-	-	-	-	-	-	-	YgbA_NO
k59_441967_3	583355.Caka_2912	1.01e-46	163.0	COG3303@1|root,COG3303@2|Bacteria,46UP1@74201|Verrucomicrobia,3K7Z3@414999|Opitutae	414999|Opitutae	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C552
k59_441969_1	1049564.TevJSym_ac01640	1.04e-133	384.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1J4RI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	COG0842 ABC-type multidrug transport system, permease component	yadH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_441969_2	765912.Thimo_2103	3.55e-19	85.5	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,1WWXT@135613|Chromatiales	135613|Chromatiales	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_1271333_1	1276920.ADIAG_03254	1.87e-11	70.1	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,1W7ZG@1268|Micrococcaceae	201174|Actinobacteria	D	Belongs to the FtsK SpoIIIE SftA family	ftsK	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1380963_1	754477.Q7C_704	4.29e-64	215.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,45ZQX@72273|Thiotrichales	72273|Thiotrichales	V	ABC transporter transmembrane region	-	-	-	ko:K12541	ko02010,map02010	M00330	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.3,3.A.1.109.4	-	-	ABC_membrane,ABC_tran,Peptidase_C39
k59_1380963_2	686340.Metal_2567	2.46e-09	59.7	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,1RNK4@1236|Gammaproteobacteria,1XGIM@135618|Methylococcales	135618|Methylococcales	M	TIGRFAM type I secretion membrane fusion protein, HlyD	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_1339675_1	880072.Desac_0400	6.24e-106	315.0	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,42M4E@68525|delta/epsilon subdivisions,2WKFT@28221|Deltaproteobacteria,2MQ5J@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
k59_1505681_1	1267005.KB911256_gene1887	5.14e-20	81.6	COG3242@1|root,COG3242@2|Bacteria,1NGPZ@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	MA20_02305	-	-	ko:K09937	-	-	-	-	ko00000	-	-	-	DUF2065
k59_1505681_2	744980.TRICHSKD4_4610	5.57e-69	221.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2TRP4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_928307_1	269799.Gmet_1092	8.98e-129	374.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,42S6H@68525|delta/epsilon subdivisions,2WNDC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_789356_1	523791.Kkor_1776	2.98e-68	230.0	COG2866@1|root,COG2866@2|Bacteria,1MZYN@1224|Proteobacteria,1RXX1@1236|Gammaproteobacteria,1XQQE@135619|Oceanospirillales	135619|Oceanospirillales	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14,Peptidase_M6
k59_677389_1	298655.KI912266_gene4997	6.91e-135	405.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4EU81@85013|Frankiales	201174|Actinobacteria	L	ABC transporter	uvrA2	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_149099_1	582899.Hden_0046	9.72e-84	270.0	2CYKW@1|root,32T4E@2|Bacteria,1N3JA@1224|Proteobacteria,2UEZF@28211|Alphaproteobacteria,3N7PP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1380970_1	497964.CfE428DRAFT_2462	4.61e-36	134.0	COG0105@1|root,COG0105@2|Bacteria,46T8K@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Nucleoside diphosphate kinase	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
k59_1380970_2	1033802.SSPSH_001952	5.63e-27	108.0	COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,1RN02@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	aminotransferase	aspC	-	2.6.1.1,2.6.1.57	ko:K00813,ko:K00832	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	M00024,M00025,M00034,M00040	R00355,R00694,R00734,R00896,R01731,R02433,R02619,R05052,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_149101_1	1123392.AQWL01000004_gene2819	1.64e-84	280.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,2VK56@28216|Betaproteobacteria,1KS71@119069|Hydrogenophilales	119069|Hydrogenophilales	CP	Domain related to MnhB subunit of Na+/H+ antiporter	-	-	-	ko:K05559	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
k59_1733235_1	626939.HMPREF9443_00948	1.47e-18	91.3	COG0772@1|root,COG0772@2|Bacteria,1TPGH@1239|Firmicutes,4H21I@909932|Negativicutes	909932|Negativicutes	M	Peptidoglycan polymerase that is essential for cell wall elongation	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_1790176_1	95619.PM1_0201110	1.42e-128	386.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_559262_1	880072.Desac_2719	9.91e-57	199.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria,2MQA8@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_281430_1	391937.NA2_08189	1.52e-57	186.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2TRWY@28211|Alphaproteobacteria,43I17@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	involved in molybdopterin and thiamine biosynthesis family 2	moeB	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
k59_399951_1	1408813.AYMG01000006_gene4188	3.99e-27	108.0	COG5587@1|root,COG5587@2|Bacteria,4NNS3@976|Bacteroidetes,1IWT7@117747|Sphingobacteriia	976|Bacteroidetes	S	Conserved hypothetical protein (DUF2461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
k59_853021_1	2340.JV46_23230	2.12e-163	466.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,1J4NC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
k59_399957_1	1207076.ALAT01000115_gene3576	2.38e-27	113.0	COG0668@1|root,COG0668@2|Bacteria,1N2GE@1224|Proteobacteria,1SBRX@1236|Gammaproteobacteria,1Z16X@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	M	CmpX protein	cmpX	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
k59_281439_1	582899.Hden_0630	3.56e-82	266.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2TRC1@28211|Alphaproteobacteria,3N6K7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	RNB,S1
k59_1339715_1	411473.RUMCAL_02325	5.93e-40	146.0	COG0423@1|root,COG0423@2|Bacteria,1TP94@1239|Firmicutes,248FB@186801|Clostridia,3WGTU@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
k59_281454_1	279714.FuraDRAFT_0982	1.48e-81	252.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2VHW4@28216|Betaproteobacteria,2KPS0@206351|Neisseriales	206351|Neisseriales	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
k59_1556815_2	472759.Nhal_2070	1.81e-137	417.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1WWJI@135613|Chromatiales	135613|Chromatiales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_324915_1	864069.MicloDRAFT_00057990	2.21e-38	137.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,2TRFS@28211|Alphaproteobacteria,1JTQY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	PFAM Methyltransferase type 11	bioC	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
k59_324915_2	414684.RC1_3081	5.41e-05	44.3	COG4321@1|root,COG4321@2|Bacteria,1N6V0@1224|Proteobacteria,2UFNN@28211|Alphaproteobacteria,2JU24@204441|Rhodospirillales	204441|Rhodospirillales	S	Ribbon-helix-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	RHH_4
k59_324920_1	1265313.HRUBRA_01067	0.000598	47.0	COG1309@1|root,COG1309@2|Bacteria,1PGTW@1224|Proteobacteria,1RUN5@1236|Gammaproteobacteria,1JBEQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
k59_442029_1	56780.SYN_02232	2.07e-69	220.0	COG1980@1|root,COG1980@2|Bacteria,1MXM7@1224|Proteobacteria,42YTY@68525|delta/epsilon subdivisions,2WTMS@28221|Deltaproteobacteria,2MRGZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Fructose-1,6-bisphosphatase	-	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
k59_853046_1	471853.Bcav_2175	1.3e-117	358.0	COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0040007,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_442033_1	768671.ThimaDRAFT_3547	6.17e-99	304.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,1S124@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	BT1 family	-	-	-	-	-	-	-	-	-	-	-	-	BT1
k59_1339771_1	1121405.dsmv_3252	1.08e-85	264.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,42M67@68525|delta/epsilon subdivisions,2WJQX@28221|Deltaproteobacteria,2MIZT@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Cys Met metabolism pyridoxal-phosphate-dependent protein	-	-	4.4.1.11	ko:K01761	ko00270,ko00450,map00270,map00450	-	R00654,R04770	RC00196,RC00348,RC01209,RC01210	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k59_1556835_1	1265503.KB905167_gene1637	1.31e-50	180.0	COG0834@1|root,COG1301@1|root,COG0834@2|Bacteria,COG1301@2|Bacteria,1P22C@1224|Proteobacteria,1RSGY@1236|Gammaproteobacteria,2Q6JC@267889|Colwelliaceae	1236|Gammaproteobacteria	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3,SDF
k59_994156_2	754477.Q7C_2190	5.23e-48	162.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,45ZZM@72273|Thiotrichales	72273|Thiotrichales	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
k59_1445349_1	670307.HYPDE_39613	1.34e-73	241.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2TRCK@28211|Alphaproteobacteria,3N7WD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Peptidase family M3	dcp	GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
k59_113197_3	314256.OG2516_05588	1.89e-33	125.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2PDVS@252301|Oceanicola	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	MA20_38030	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_994158_1	252305.OB2597_16807	2.22e-101	306.0	COG3666@1|root,COG3666@2|Bacteria,1QW5T@1224|Proteobacteria,2TWNW@28211|Alphaproteobacteria,2PDPW@252301|Oceanicola	28211|Alphaproteobacteria	L	Transposase DDE domain	tnp*	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_934915_1	1163617.SCD_n01730	1.09e-154	456.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJI0@28216|Betaproteobacteria	28216|Betaproteobacteria	P	von Willebrand factor (vWF) type A domain	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA_2
k59_153782_1	665029.EAMY_3683	5.5e-78	248.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,3X4GW@551|Erwinia	1236|Gammaproteobacteria	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_622341_1	314278.NB231_04715	1e-51	171.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,1RNVM@1236|Gammaproteobacteria,1WXMH@135613|Chromatiales	135613|Chromatiales	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
k59_505188_1	686578.AFFX01000011_gene2528	3.83e-72	232.0	COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,1RMI9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	'catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway'	hutI	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0052803,GO:0052805,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
k59_682051_1	768671.ThimaDRAFT_0802	2.45e-115	341.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVK@1236|Gammaproteobacteria,1X2B5@135613|Chromatiales	1236|Gammaproteobacteria	NU	PFAM Sulphatase-modifying factor	-	-	-	ko:K20333	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	FGE-sulfatase,PEGA,Pkinase
k59_113230_1	648757.Rvan_0593	1.87e-120	358.0	COG0247@1|root,COG0479@1|root,COG0247@2|Bacteria,COG0479@2|Bacteria,1NZIG@1224|Proteobacteria,2VGKY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
k59_1510762_1	1286106.MPL1_02558	2.91e-39	144.0	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,1RP1B@1236|Gammaproteobacteria,4623J@72273|Thiotrichales	72273|Thiotrichales	C	formate dehydrogenase	-	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
k59_1510762_2	380703.AHA_3062	3.03e-06	49.3	COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,1RRAN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	fdhB	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_4,Fer4_7
k59_1619623_1	1122603.ATVI01000005_gene3501	5.24e-20	93.2	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SZ6C@1236|Gammaproteobacteria,1XCCV@135614|Xanthomonadales	1236|Gammaproteobacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_19,TPR_2,TPR_8
k59_682062_2	1306990.BARG01000006_gene364	0.000175	47.0	COG1309@1|root,COG1309@2|Bacteria,2HG87@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_212201_1	314278.NB231_01334	2.33e-43	154.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1WWER@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
k59_682069_1	1043493.BBLU01000003_gene2293	1.42e-32	129.0	COG2836@1|root,COG4633@1|root,COG2836@2|Bacteria,COG4633@2|Bacteria,2IETB@201174|Actinobacteria	201174|Actinobacteria	P	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,DsbD_2,HMA
k59_329579_1	1454010.JEOE01000011_gene2396	8.53e-67	223.0	COG4425@1|root,COG4425@2|Bacteria,2IBWT@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta-hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_9,Abhydrolase_9_N
k59_1445389_1	1049564.TevJSym_aa01910	1.34e-18	79.3	COG3255@1|root,COG3255@2|Bacteria,1RI49@1224|Proteobacteria,1S38T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1445389_2	765911.Thivi_3955	7.84e-25	102.0	COG0699@1|root,COG0699@2|Bacteria,1MV59@1224|Proteobacteria,1RYGW@1236|Gammaproteobacteria,1WWCT@135613|Chromatiales	135613|Chromatiales	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_740725_1	323261.Noc_1259	1.49e-25	114.0	COG2982@1|root,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,1RNPC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748,OmpA
k59_1101982_1	795666.MW7_2236	9.45e-105	329.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,1K1J9@119060|Burkholderiaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_994215_1	591158.SSMG_04573	7.2e-145	418.0	COG0598@1|root,COG0598@2|Bacteria,2GKNZ@201174|Actinobacteria	201174|Actinobacteria	P	Magnesium transport protein CorA	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
k59_994215_2	1123024.AUII01000036_gene3156	3.71e-115	349.0	COG0038@1|root,COG0038@2|Bacteria,2GJHP@201174|Actinobacteria,4E870@85010|Pseudonocardiales	201174|Actinobacteria	P	Voltage gated chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
k59_857412_1	435830.HMPREF0045_01770	1.08e-94	295.0	COG0488@1|root,COG0488@2|Bacteria,2GJ5M@201174|Actinobacteria,4D3UR@85005|Actinomycetales	201174|Actinobacteria	S	ABC transporter, ATP-binding protein	yjjK	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_563782_1	1267005.KB911264_gene3151	6.1e-70	226.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,2TRP5@28211|Alphaproteobacteria,3N6KB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
k59_55099_1	1049564.TevJSym_ag00600	8.28e-47	169.0	COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,1J6A4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	PT	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,cNMP_binding
k59_329604_1	290400.Jann_3107	5.25e-09	55.8	COG1136@1|root,COG1136@2|Bacteria,1RA1K@1224|Proteobacteria,2U7CA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG1136 ABC-type antimicrobial peptide transport system ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_329604_2	243233.MCA2173	2.12e-27	111.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	MacB_PCD
k59_1510800_1	998674.ATTE01000001_gene2309	4.15e-74	227.0	COG1573@1|root,COG1573@2|Bacteria	2|Bacteria	L	deaminated base DNA N-glycosylase activity	ung	-	3.2.2.27	ko:K03648,ko:K21929	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4130,UDG
k59_1102005_1	1046724.KB889955_gene2500	1.75e-31	124.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,466AG@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9
k59_1561453_1	105559.Nwat_1651	6.18e-69	221.0	COG0823@1|root,COG0823@2|Bacteria,1QW3I@1224|Proteobacteria,1SYTE@1236|Gammaproteobacteria,1X0JZ@135613|Chromatiales	135613|Chromatiales	U	beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40
k59_212234_1	998674.ATTE01000001_gene2176	1.09e-40	146.0	COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S dicluster domain	dsrK	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8
k59_1346692_1	247490.KSU1_C0717	2.25e-43	161.0	COG0826@1|root,COG0826@2|Bacteria,2IYDC@203682|Planctomycetes	203682|Planctomycetes	O	Collagenase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
k59_55120_2	396588.Tgr7_2200	1e-36	136.0	2CB8R@1|root,2Z90U@2|Bacteria,1R4DV@1224|Proteobacteria,1RPSZ@1236|Gammaproteobacteria,1WZX3@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1028958_1	582899.Hden_0830	2.3e-49	162.0	COG3476@1|root,COG3476@2|Bacteria,1MZC1@1224|Proteobacteria,2UBYB@28211|Alphaproteobacteria,3N76W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	TspO/MBR family	tspO	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
k59_329613_1	1158165.KB898880_gene1532	2.03e-67	214.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1WW40@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM Tyrosine recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_682106_1	1280686.AUKE01000011_gene1727	1.02e-11	63.9	COG0444@1|root,COG0444@2|Bacteria,1UX99@1239|Firmicutes,25KBT@186801|Clostridia,4BWQT@830|Butyrivibrio	186801|Clostridia	EP	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
k59_1737871_1	1307759.JOMJ01000003_gene927	3.17e-94	299.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,42SZ0@68525|delta/epsilon subdivisions,2WPIR@28221|Deltaproteobacteria,2MAQX@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	DEAD-like helicase	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
k59_1737871_2	643562.Daes_1658	2.15e-190	544.0	COG1524@1|root,COG1524@2|Bacteria,1PGPZ@1224|Proteobacteria,42NY9@68525|delta/epsilon subdivisions,2WM0S@28221|Deltaproteobacteria,2MA83@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PglZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PglZ
k59_1210185_1	768671.ThimaDRAFT_2230	1.77e-70	232.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RR5Z@1236|Gammaproteobacteria,1WXE4@135613|Chromatiales	135613|Chromatiales	J	Allophanate hydrolase	-	-	3.5.1.54	ko:K01457	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120	-	R00005	RC02756	ko00000,ko00001,ko01000	-	-	-	Amidase
k59_1385700_2	563192.HMPREF0179_01781	4.07e-15	75.1	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,42PB7@68525|delta/epsilon subdivisions,2WJX5@28221|Deltaproteobacteria,2MA0E@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
k59_792997_1	1163617.SCD_n02376	7.52e-78	240.0	2CPZ1@1|root,32SK5@2|Bacteria,1N2AX@1224|Proteobacteria,2W1HP@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1737876_2	1123070.KB899247_gene1447	2.59e-65	207.0	COG1136@1|root,COG1136@2|Bacteria,46V4K@74201|Verrucomicrobia,2IW00@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_1147000_1	179408.Osc7112_1976	1.38e-28	123.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2461@1|root,COG3829@1|root,COG5000@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG2461@2|Bacteria,COG3829@2|Bacteria,COG5000@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k59_1619675_1	118166.JH976537_gene4025	2.35e-44	161.0	COG3408@1|root,COG3408@2|Bacteria,1G2AS@1117|Cyanobacteria,1H7MX@1150|Oscillatoriales	1117|Cyanobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
k59_1346719_1	1335757.SPICUR_03525	3.04e-29	115.0	COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,1WWKI@135613|Chromatiales	135613|Chromatiales	G	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane	lapB	-	-	ko:K19804	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_7
k59_1346719_2	1255043.TVNIR_1805	1.93e-48	156.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,1S8XZ@1236|Gammaproteobacteria,1WYM5@135613|Chromatiales	135613|Chromatiales	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_406884_1	1122951.ATUE01000008_gene233	1.99e-98	306.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,3NIRS@468|Moraxellaceae	1236|Gammaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iEC042_1314.EC042_2346,iECUMN_1333.ECUMN_2446	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_1680409_2	367299.JOEE01000001_gene1896	7.5e-110	331.0	COG2890@1|root,COG2890@2|Bacteria,2GJPP@201174|Actinobacteria,4FFPS@85021|Intrasporangiaceae	201174|Actinobacteria	J	SAM-dependent methyltransferase	rsmC	-	-	-	-	-	-	-	-	-	-	-	MTS
k59_329632_1	1121013.P873_12825	6.44e-17	85.1	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria,1X3GK@135614|Xanthomonadales	135614|Xanthomonadales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_16
k59_1210199_1	765911.Thivi_2306	2.98e-68	213.0	COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,1RRMA@1236|Gammaproteobacteria,1WWEH@135613|Chromatiales	135613|Chromatiales	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_1210199_2	857087.Metme_3070	1.04e-13	70.1	COG1305@1|root,COG1305@2|Bacteria,1MVAG@1224|Proteobacteria,1RMXM@1236|Gammaproteobacteria,1XEW2@135618|Methylococcales	1236|Gammaproteobacteria	E	Bacterial transglutaminase-like N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_288009_2	468556.AQYG01000035_gene328	1.54e-64	212.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4GAFJ@85026|Gordoniaceae	201174|Actinobacteria	IQ	AMP-binding enzyme	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_935048_2	1499967.BAYZ01000095_gene4090	1.25e-07	57.8	COG0653@1|root,COG0653@2|Bacteria,2NNRK@2323|unclassified Bacteria	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_622434_1	1121405.dsmv_2856	4.27e-74	240.0	COG3039@1|root,COG3039@2|Bacteria,1PKUP@1224|Proteobacteria,43ECD@68525|delta/epsilon subdivisions,2X0BQ@28221|Deltaproteobacteria,2MP4F@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_563832_1	1121405.dsmv_0170	1.5e-78	252.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WIJY@28221|Deltaproteobacteria,2MHT0@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
k59_446641_1	1396858.Q666_01925	1.21e-75	234.0	COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,1RR5P@1236|Gammaproteobacteria,4664C@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	LigB
k59_1029014_1	519989.ECTPHS_10381	8.88e-50	171.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,1WVX4@135613|Chromatiales	135613|Chromatiales	I	TIGRFAM acetyl-CoA carboxylase, biotin carboxylase	-	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_935056_1	158190.SpiGrapes_0701	2.13e-48	163.0	COG1192@1|root,COG1192@2|Bacteria,2J7VF@203691|Spirochaetes	203691|Spirochaetes	D	PFAM CobQ CobB MinD ParA nucleotide binding domain	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_1510864_1	471853.Bcav_1029	1.59e-91	282.0	COG1252@1|root,COG1252@2|Bacteria,2GJFE@201174|Actinobacteria	201174|Actinobacteria	C	NADH dehydrogenase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_56242_1	58123.JOFJ01000003_gene2048	3.38e-35	137.0	COG2844@1|root,COG2844@2|Bacteria,2GMKT@201174|Actinobacteria,4EFUU@85012|Streptosporangiales	201174|Actinobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_1147850_1	666685.R2APBS1_2801	6.34e-18	86.7	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,1T1G3@1236|Gammaproteobacteria,1X49E@135614|Xanthomonadales	135614|Xanthomonadales	T	Two-component sensor kinase N-terminal	-	-	2.7.13.3	ko:K07645	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
k59_564780_1	626887.J057_22015	1.39e-80	246.0	COG0500@1|root,COG2226@2|Bacteria,1RANW@1224|Proteobacteria,1S1F0@1236|Gammaproteobacteria,467F2@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
k59_858291_1	1265505.ATUG01000001_gene3443	2.82e-83	255.0	COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,42Q6C@68525|delta/epsilon subdivisions,2WMD6@28221|Deltaproteobacteria,2MHY6@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k59_114690_1	643648.Slip_2358	1.25e-69	218.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,42JRV@68298|Syntrophomonadaceae	186801|Clostridia	E	PFAM ABC transporter related	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_1348060_1	367299.JOEE01000004_gene1271	1.33e-106	313.0	COG2240@1|root,COG2240@2|Bacteria,2HS59@201174|Actinobacteria,4FF4R@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the pyridoxine kinase family	pdxY	-	2.7.1.35	ko:K00868	ko00750,ko01100,map00750,map01100	-	R00174,R01909,R02493	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	Phos_pyr_kin
k59_408203_1	613026.HRAG_01644	1.24e-58	192.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2YMDC@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_1030108_2	595494.Tola_1620	3.42e-25	96.3	COG0832@1|root,COG0832@2|Bacteria,1RGW0@1224|Proteobacteria,1S8UP@1236|Gammaproteobacteria,1Y5UY@135624|Aeromonadales	135624|Aeromonadales	E	Belongs to the urease beta subunit family	ureB	-	3.5.1.5	ko:K01429	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Urease_beta
k59_858299_2	765910.MARPU_11700	1.21e-139	400.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1WX3I@135613|Chromatiales	135613|Chromatiales	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_1566110_2	622637.KE124770_gene148	2.32e-68	223.0	COG1389@1|root,COG1389@2|Bacteria,1R6T0@1224|Proteobacteria	1224|Proteobacteria	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,HATPase_c_3,Topo-VIb_trans
k59_1107552_1	314266.SKA58_02345	1.59e-32	130.0	COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,2U9U2@28211|Alphaproteobacteria,2K02C@204457|Sphingomonadales	204457|Sphingomonadales	S	IS66 C-terminal element	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_1624316_1	485913.Krac_2496	4.79e-63	212.0	COG1132@1|root,COG1132@2|Bacteria,2G5QH@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_216947_1	446469.Sked_32170	2.3e-70	228.0	COG2021@1|root,COG2021@2|Bacteria,2GKNJ@201174|Actinobacteria	201174|Actinobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_796921_1	246195.DNO_0028	1.06e-05	46.2	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
k59_796921_2	350688.Clos_1530	1.1e-25	105.0	COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia,36DFF@31979|Clostridiaceae	186801|Clostridia	S	domain protein	nrnA	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_1390361_1	1089550.ATTH01000001_gene1653	2.47e-11	63.9	COG0240@1|root,COG0240@2|Bacteria,4NF4R@976|Bacteroidetes,1FIU2@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	I	glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
k59_1390361_2	1286106.MPL1_09682	3e-29	110.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,460QW@72273|Thiotrichales	72273|Thiotrichales	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	-	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
k59_1798539_1	1267005.KB911257_gene869	1.39e-111	338.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2TR63@28211|Alphaproteobacteria,3N6E1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	GTP-binding protein	typA	GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_1390365_1	367299.JOEE01000004_gene1093	2.09e-93	281.0	COG0059@1|root,COG0059@2|Bacteria,2GKXA@201174|Actinobacteria,4FEUM@85021|Intrasporangiaceae	201174|Actinobacteria	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008677,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
k59_1516176_1	1279017.AQYJ01000026_gene57	4.58e-59	207.0	COG1360@1|root,COG2885@1|root,COG1360@2|Bacteria,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,1T4AK@1236|Gammaproteobacteria,46ACU@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,OmpA
k59_862429_1	880073.Calab_3182	2.94e-20	94.0	COG2067@1|root,COG2067@2|Bacteria,2NQYN@2323|unclassified Bacteria	2|Bacteria	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_158764_1	768671.ThimaDRAFT_2575	6.16e-63	205.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1WWFQ@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
k59_1685450_1	105559.Nwat_0845	4.17e-122	363.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,1WVZV@135613|Chromatiales	135613|Chromatiales	P	PFAM Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
k59_1516190_1	1300345.LF41_3210	2.86e-67	217.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1X3F0@135614|Xanthomonadales	135614|Xanthomonadales	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_1281964_1	204773.HEAR3154	2.63e-08	53.5	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,2VHCP@28216|Betaproteobacteria,473H5@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
k59_1281964_2	279714.FuraDRAFT_3628	4.42e-52	166.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2VUC6@28216|Betaproteobacteria,2KRCP@206351|Neisseriales	206351|Neisseriales	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
k59_862448_1	1282876.BAOK01000002_gene134	1.3e-37	142.0	COG3746@1|root,COG3746@2|Bacteria,1RA39@1224|Proteobacteria,2U9KD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	PFAM Phosphate-selective porin O and P	-	-	-	ko:K07221	-	-	-	-	ko00000,ko02000	1.B.5.1	-	-	Porin_O_P
k59_568884_1	1297742.A176_03977	2.08e-15	77.4	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42N0H@68525|delta/epsilon subdivisions,2WK9P@28221|Deltaproteobacteria,2YU8N@29|Myxococcales	28221|Deltaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_568884_2	1118235.CAJH01000009_gene568	8.84e-61	194.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,1RQJT@1236|Gammaproteobacteria,1X30J@135614|Xanthomonadales	135614|Xanthomonadales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k59_745729_1	1379270.AUXF01000001_gene2167	8.04e-19	84.3	28IQM@1|root,2Z8QA@2|Bacteria	2|Bacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
k59_745729_2	1356852.N008_01240	8.02e-20	87.8	COG4874@1|root,COG4874@2|Bacteria,4NFG3@976|Bacteroidetes,47KEY@768503|Cytophagia	976|Bacteroidetes	S	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
k59_687013_1	572477.Alvin_1437	2.66e-110	342.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales	135613|Chromatiales	D	DNA segregation ATPase FtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_1034556_1	1118153.MOY_14960	1.73e-52	178.0	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,1RP1B@1236|Gammaproteobacteria,1XIRN@135619|Oceanospirillales	135619|Oceanospirillales	C	COG2864 Cytochrome b subunit of formate dehydrogenase	-	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
k59_510430_2	713586.KB900536_gene937	3.25e-51	179.0	COG4191@1|root,COG4191@2|Bacteria,1QVHZ@1224|Proteobacteria,1S2DC@1236|Gammaproteobacteria,1WZY5@135613|Chromatiales	135613|Chromatiales	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_1215229_1	1458357.BG58_25750	9.06e-104	308.0	COG4525@1|root,COG4525@2|Bacteria,1QTUA@1224|Proteobacteria,2VIKA@28216|Betaproteobacteria,1K2BN@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system	tauB	-	3.6.3.36	ko:K10831	ko00920,ko02010,map00920,map02010	M00435	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.17.1,3.A.1.17.4	-	-	ABC_tran
k59_568892_1	471853.Bcav_2785	9.88e-31	116.0	2EBSZ@1|root,335SP@2|Bacteria,2GS6Y@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Tad
k59_568892_2	446466.Cfla_1240	1.26e-37	134.0	2E9Y4@1|root,3343S@2|Bacteria,2GR3H@201174|Actinobacteria,4F1KE@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM TadE family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_568892_3	593907.Celgi_2319	1.68e-29	109.0	2CXFQ@1|root,32T1V@2|Bacteria,2GQYH@201174|Actinobacteria,4F1HG@85016|Cellulomonadaceae	201174|Actinobacteria	S	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
k59_1107636_1	1171373.PACID_19390	7.67e-14	72.0	COG0711@1|root,COG0711@2|Bacteria,2GJS4@201174|Actinobacteria,4DQDT@85009|Propionibacteriales	201174|Actinobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
k59_745745_1	1437882.AZRU01000035_gene387	6.07e-126	374.0	COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,1RQHX@1236|Gammaproteobacteria,1YEE5@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4478)	ygdH	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016798,GO:0016799,GO:0044424,GO:0044444,GO:0044464,GO:0047405	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DUF3412,DUF4478,Lysine_decarbox
k59_217015_1	713587.THITH_08770	4.61e-89	273.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1WVYY@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM isocitrate dehydrogenase, NADP-dependent	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,Iso_dh
k59_1107639_1	365044.Pnap_1457	1.37e-37	134.0	COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,2VRSU@28216|Betaproteobacteria,4AEW7@80864|Comamonadaceae	28216|Betaproteobacteria	M	PFAM Lipocalin family protein	blc	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
k59_510450_1	1509405.GV67_07380	9.9e-70	222.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,4BBSC@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1281997_1	926569.ANT_24870	9.19e-56	180.0	COG1418@1|root,COG1418@2|Bacteria,2G77Y@200795|Chloroflexi	200795|Chloroflexi	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
k59_1450513_1	570268.ANBB01000055_gene4855	2.89e-30	108.0	COG0140@1|root,COG0140@2|Bacteria,2IQ4D@201174|Actinobacteria,4EK7H@85012|Streptosporangiales	201174|Actinobacteria	E	Phosphoribosyl-ATP pyrophosphohydrolase	hisE	GO:0000287,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009605,GO:0009607,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0044403,GO:0044419,GO:0044464,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0071944,GO:0075136,GO:0075139	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
k59_1450513_2	935839.JAGJ01000003_gene1524	8.26e-105	310.0	COG0040@1|root,COG0040@2|Bacteria,2GNAX@201174|Actinobacteria,4F40N@85017|Promicromonosporaceae	201174|Actinobacteria	E	ATP phosphoribosyltransferase	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
k59_510459_1	267377.MMP0538	1.25e-06	49.3	arCOG06621@1|root,arCOG06621@2157|Archaea,2Y3GZ@28890|Euryarchaeota,23RKE@183939|Methanococci	183939|Methanococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_217028_1	1128427.KB904821_gene351	6.52e-19	85.5	COG3001@1|root,COG3001@2|Bacteria,1G040@1117|Cyanobacteria,1H92D@1150|Oscillatoriales	1117|Cyanobacteria	G	PFAM Fructosamine kinase	-	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237	-	-	-	-	-	-	-	-	-	-	Fructosamin_kin
k59_217028_2	768671.ThimaDRAFT_1293	6.24e-49	161.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1WWXG@135613|Chromatiales	135613|Chromatiales	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
k59_1685517_1	58344.JOEL01000036_gene4116	6.88e-44	150.0	COG1670@1|root,COG1670@2|Bacteria,2IHXG@201174|Actinobacteria	201174|Actinobacteria	J	Acetyltransferases including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
k59_1566228_1	243365.CV_0121	9.74e-20	87.4	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2VH15@28216|Betaproteobacteria,2KPK9@206351|Neisseriales	206351|Neisseriales	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_1625901_1	1384054.N790_11375	6.35e-43	162.0	COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,1RPY8@1236|Gammaproteobacteria,1X47V@135614|Xanthomonadales	135614|Xanthomonadales	M	Protein of unknown function (DUF1302)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1302
k59_1452092_1	1449044.JMLE01000001_gene3834	6.14e-45	162.0	arCOG08054@1|root,2Z8AD@2|Bacteria,2GKIT@201174|Actinobacteria,1WAKQ@1268|Micrococcaceae	201174|Actinobacteria	S	Carbohydrate-binding domain-containing protein Cthe_2159	-	-	-	-	-	-	-	-	-	-	-	-	Cthe_2159
k59_688421_1	1298860.AUEM01000007_gene1872	4.36e-116	339.0	COG1177@1|root,COG1177@2|Bacteria,2GJ6Q@201174|Actinobacteria,4FNB3@85023|Microbacteriaceae	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11070,ko:K11074	ko02010,map02010	M00299,M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1,3.A.1.11.2	-	-	BPD_transp_1
k59_1152757_1	28072.Nos7524_1286	7.43e-49	186.0	COG2931@1|root,COG3210@1|root,COG3291@1|root,COG3595@1|root,COG4070@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG3595@2|Bacteria,COG4070@2|Bacteria,1GHDQ@1117|Cyanobacteria,1HUA0@1161|Nostocales	1117|Cyanobacteria	Q	Domain of unknown function (DUF4114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114
k59_747176_1	631362.Thi970DRAFT_04513	1.04e-50	183.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1WWGW@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM ATP-dependent helicase HrpA	-	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_1687057_1	1089551.KE386572_gene1293	7.74e-32	123.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2TSWH@28211|Alphaproteobacteria,4BPR9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	D	PFAM CobQ CobB MinD ParA nucleotide binding domain	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_1625928_1	63737.Npun_R1898	2.79e-32	122.0	COG0604@1|root,COG0604@2|Bacteria,1FZW8@1117|Cyanobacteria,1HKMY@1161|Nostocales	1117|Cyanobacteria	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
k59_160195_1	477228.YO5_09013	1.1e-112	336.0	COG0189@1|root,COG0189@2|Bacteria,1MVDU@1224|Proteobacteria,1RR7D@1236|Gammaproteobacteria,1Z010@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	HJ	Glutathione synthase Ribosomal protein S6 modification	PA1766	-	-	-	-	-	-	-	-	-	-	-	ATPgrasp_ST
k59_160195_2	472759.Nhal_2058	1.85e-38	142.0	COG1305@1|root,COG1305@2|Bacteria,1MVV3@1224|Proteobacteria,1RRIA@1236|Gammaproteobacteria,1X0CC@135613|Chromatiales	135613|Chromatiales	E	7 transmembrane helices usually fused to an inactive transglutaminase	-	-	-	-	-	-	-	-	-	-	-	-	7TM_transglut,Transglut_i_TM
k59_336502_1	237368.SCABRO_03842	3.39e-17	83.6	COG1538@1|root,COG1538@2|Bacteria,2IX1X@203682|Planctomycetes	203682|Planctomycetes	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
k59_336502_2	195250.CM001776_gene735	2.41e-17	82.4	COG0841@1|root,COG0841@2|Bacteria,1G0C2@1117|Cyanobacteria,1GYJ5@1129|Synechococcus	1117|Cyanobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_1284008_1	1045009.AFXQ01000011_gene460	2.21e-52	172.0	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,1W7J9@1268|Micrococcaceae	201174|Actinobacteria	G	Inositol monophosphatase family	hisN	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15,3.1.3.25	ko:K01092,ko:K05602	ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00131	R01185,R01186,R01187,R03013	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
k59_1284008_2	266940.Krad_1208	2.43e-74	235.0	COG1162@1|root,COG1162@2|Bacteria,2GJ37@201174|Actinobacteria	201174|Actinobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
k59_1452121_1	566466.NOR53_3289	1.8e-76	251.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1J7M2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_218455_2	187272.Mlg_2443	1.88e-29	108.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,1WYPW@135613|Chromatiales	135613|Chromatiales	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
k59_336510_1	335543.Sfum_0609	7.19e-95	282.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	iron-sulfur binding	qrcC	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
k59_1284019_1	1229909.NSED_08780	1.26e-107	319.0	COG0604@1|root,arCOG01458@2157|Archaea,41SZ9@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_798050_1	1342302.JASC01000013_gene2850	1.83e-25	105.0	COG2186@1|root,COG2186@2|Bacteria,1R5KH@1224|Proteobacteria,2TSJE@28211|Alphaproteobacteria,3ZXK0@60136|Sulfitobacter	28211|Alphaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_864116_1	494419.ALPM01000122_gene1260	4.44e-22	88.6	2EK1R@1|root,33DS7@2|Bacteria,2HZFZ@201174|Actinobacteria,1WA4V@1268|Micrococcaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
k59_160226_1	930169.B5T_01084	2.16e-95	290.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1XI9W@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
k59_1109509_2	590998.Celf_2463	1.49e-37	134.0	2E4C6@1|root,32Z7Q@2|Bacteria,2GRH1@201174|Actinobacteria,4F1I8@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_864131_1	1293054.HSACCH_00883	2e-51	181.0	COG0145@1|root,COG0145@2|Bacteria,1TQVB@1239|Firmicutes,24AJ7@186801|Clostridia,3WADC@53433|Halanaerobiales	186801|Clostridia	EQ	COGs COG0145 N-methylhydantoinase A acetone carboxylase beta subunit	hyuA	-	-	-	-	-	-	-	-	-	-	-	Hydant_A_N,Hydantoinase_A
k59_1152805_1	1713.JOFV01000011_gene2464	3.21e-70	240.0	COG4733@1|root,COG4733@2|Bacteria,2GMKC@201174|Actinobacteria,4F251@85016|Cellulomonadaceae	201174|Actinobacteria	S	SMART Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	fn3
k59_218477_1	388051.AUFE01000024_gene4679	3.69e-50	165.0	COG2891@1|root,COG2891@2|Bacteria,1RBNF@1224|Proteobacteria,2VQQ3@28216|Betaproteobacteria,1K3V9@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Rod shape-determining protein MreD	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
k59_747230_1	1266925.JHVX01000007_gene2421	3.63e-80	245.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2VN0K@28216|Betaproteobacteria,374M2@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_1625975_1	670307.HYPDE_23853	1.48e-31	120.0	COG3814@1|root,COG3814@2|Bacteria,1N1FE@1224|Proteobacteria,2U7H9@28211|Alphaproteobacteria,3N6YU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Stringent starvation protein B	MA20_02250	-	-	ko:K09985	-	-	-	-	ko00000	-	-	-	SspB
k59_688483_1	1109445.AGSX01000193_gene490	5.41e-142	429.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1YZZJ@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
k59_1109528_1	335543.Sfum_1695	4.05e-91	277.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2MQ3Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	NU	PFAM Type II IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_453162_1	204773.HEAR1383	5.3e-48	165.0	COG2021@1|root,COG2021@2|Bacteria,1QU6N@1224|Proteobacteria,2WGNS@28216|Betaproteobacteria,472DC@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Serine aminopeptidase, S33	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
k59_798069_1	1389489.O159_16370	2.37e-10	60.5	COG0275@1|root,COG0275@2|Bacteria,2GJGK@201174|Actinobacteria,4FKB5@85023|Microbacteriaceae	201174|Actinobacteria	M	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_1401612_1	1121949.AQXT01000002_gene1166	1.12e-137	397.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TSV6@28211|Alphaproteobacteria,43WMI@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
k59_1753072_1	471853.Bcav_2369	1.44e-122	359.0	COG0078@1|root,COG0078@2|Bacteria,2GJ6H@201174|Actinobacteria	201174|Actinobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_518649_1	909663.KI867150_gene213	4.82e-71	235.0	COG0457@1|root,COG0457@2|Bacteria,1NNJ6@1224|Proteobacteria,42PBD@68525|delta/epsilon subdivisions,2WKWJ@28221|Deltaproteobacteria,2MRCI@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
k59_1160909_1	1396141.BATP01000001_gene5334	1.22e-58	187.0	COG4313@1|root,COG4313@2|Bacteria,46UHV@74201|Verrucomicrobia,2IVEU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
k59_1461561_1	1209072.ALBT01000067_gene102	5.01e-44	157.0	COG0673@1|root,COG0673@2|Bacteria,1MZIG@1224|Proteobacteria,1RS5T@1236|Gammaproteobacteria,1FFYF@10|Cellvibrio	1236|Gammaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_1807664_1	1255043.TVNIR_2230	5.55e-92	283.0	COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,1RN94@1236|Gammaproteobacteria,1WXKU@135613|Chromatiales	135613|Chromatiales	S	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
k59_1697091_2	1123368.AUIS01000009_gene2454	2.94e-90	272.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1T1HN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_518663_1	1121035.AUCH01000006_gene738	1.55e-12	64.7	2C1YJ@1|root,32ZXK@2|Bacteria,1N98H@1224|Proteobacteria,2VVT5@28216|Betaproteobacteria,2KXDS@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF2782)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2782
k59_345455_1	1121441.AUCX01000010_gene148	2.13e-25	102.0	COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,42NAS@68525|delta/epsilon subdivisions,2WNAF@28221|Deltaproteobacteria,2M9I9@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the agmatine deiminase family	aguA	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
k59_345455_2	1144275.COCOR_00925	6.62e-74	244.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2YTUI@29|Myxococcales	28221|Deltaproteobacteria	P	copper-translocating P-type ATPase	copF	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
k59_170045_1	398525.KB900701_gene4704	1.08e-103	313.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,3JVHX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_805432_1	1504672.669787262	5.52e-35	130.0	COG3424@1|root,COG3424@2|Bacteria,1MUDX@1224|Proteobacteria	1224|Proteobacteria	Q	synthase	phlD	-	2.3.1.233,2.3.1.246,2.3.1.253	ko:K15431,ko:K16167,ko:K16424,ko:K19580	ko01055,ko01130,map01055,map01130	-	R06625,R10965,R10967	RC00004,RC02933,RC03463	ko00000,ko00001,ko01000,ko01008	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N,FAE1_CUT1_RppA
k59_228032_1	1300345.LF41_420	6.3e-05	45.1	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1X3WP@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_637347_1	1323663.AROI01000009_gene3697	1.67e-24	98.6	COG3631@1|root,COG3631@2|Bacteria,1NGW5@1224|Proteobacteria,1SHT8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
k59_1047791_1	765914.ThisiDRAFT_0270	3.97e-20	89.4	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1WW6C@135613|Chromatiales	135613|Chromatiales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_170069_1	1121403.AUCV01000056_gene3012	1.27e-56	194.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MHU5@213118|Desulfobacterales	28221|Deltaproteobacteria	S	pfam abc-1	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
k59_1050244_2	1047013.AQSP01000138_gene1061	0.000997	38.9	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	tatA	GO:0002790,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009977,GO:0009987,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680	-	ko:K03116,ko:K03117,ko:K03425	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_1403880_1	1469245.JFBG01000075_gene164	3.94e-61	204.0	COG0699@1|root,COG0699@2|Bacteria,1MV59@1224|Proteobacteria,1RYGW@1236|Gammaproteobacteria,1WWCT@135613|Chromatiales	135613|Chromatiales	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_229803_1	985665.HPL003_27650	1.06e-73	237.0	COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,4H9ZG@91061|Bacilli,26RAG@186822|Paenibacillaceae	91061|Bacilli	E	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687,ko:K16786	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00770,map01100,map01110,map01130,map01210,map01230,map02010	M00019,M00570,M00582	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ILVD_EDD
k59_1050253_1	870187.Thini_2282	1.2e-33	128.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RN6P@1236|Gammaproteobacteria,461X5@72273|Thiotrichales	72273|Thiotrichales	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
k59_1754654_1	990285.RGCCGE502_07454	5.84e-39	133.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2TSI8@28211|Alphaproteobacteria,4B6XZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_1699008_1	1293054.HSACCH_01202	6.13e-37	140.0	COG0168@1|root,COG0168@2|Bacteria,1TPAF@1239|Firmicutes,248K4@186801|Clostridia,3WB17@53433|Halanaerobiales	186801|Clostridia	P	PFAM Cation	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_758905_1	994479.GL877878_gene2701	1.09e-25	105.0	COG0423@1|root,COG0423@2|Bacteria,2GIT3@201174|Actinobacteria,4DXGM@85010|Pseudonocardiales	201174|Actinobacteria	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
k59_758905_2	1123065.ATWL01000007_gene3305	1.6e-72	230.0	COG5438@1|root,COG5438@2|Bacteria,2GKJ4@201174|Actinobacteria	201174|Actinobacteria	S	YibE F family protein	-	-	-	-	-	-	-	-	-	-	-	-	YibE_F
k59_638859_1	395493.BegalDRAFT_1819	1.1e-26	107.0	COG0789@1|root,COG0789@2|Bacteria,1R9SN@1224|Proteobacteria,1S78T@1236|Gammaproteobacteria,463IS@72273|Thiotrichales	72273|Thiotrichales	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
k59_638859_2	1260251.SPISAL_01695	6.32e-82	253.0	COG4221@1|root,COG4221@2|Bacteria,1R9DN@1224|Proteobacteria,1T2NM@1236|Gammaproteobacteria,1X2QY@135613|Chromatiales	135613|Chromatiales	S	Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1699009_1	572477.Alvin_0388	8.25e-63	201.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1WWQ7@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_229827_1	439235.Dalk_5159	2.03e-102	310.0	COG0191@1|root,COG0191@2|Bacteria,1NMAK@1224|Proteobacteria,42NPW@68525|delta/epsilon subdivisions,2WIMN@28221|Deltaproteobacteria,2MHU7@213118|Desulfobacterales	28221|Deltaproteobacteria	G	aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
k59_1228768_1	177437.HRM2_01500	8.78e-68	218.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,42NGK@68525|delta/epsilon subdivisions,2WM29@28221|Deltaproteobacteria,2MMM3@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Glucose-1-phosphate adenylyltransferase	-	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_1580494_1	640081.Dsui_1155	8.78e-49	173.0	COG0223@1|root,COG1024@1|root,COG0223@2|Bacteria,COG1024@2|Bacteria,1MWYJ@1224|Proteobacteria,2VK38@28216|Betaproteobacteria,2KVS4@206389|Rhodocyclales	206389|Rhodocyclales	IJ	Formyl transferase, C-terminal domain	-	-	-	ko:K19640	-	-	-	-	ko00000,ko02022	-	-	-	ECH_1,Formyl_trans_C,Formyl_trans_N
k59_806916_1	443144.GM21_0947	4.37e-15	74.3	COG0517@1|root,COG0517@2|Bacteria,1RA25@1224|Proteobacteria,42R80@68525|delta/epsilon subdivisions,2WMW6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
k59_806916_2	635013.TherJR_2235	1.19e-27	110.0	COG3383@1|root,COG3383@2|Bacteria,1TT6D@1239|Firmicutes,24YN9@186801|Clostridia,267CA@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.10,1.17.1.9	ko:K00123,ko:K05299	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_1050295_2	478801.Ksed_13560	2.08e-25	101.0	COG1119@1|root,COG1119@2|Bacteria,2GIXX@201174|Actinobacteria,1ZVQA@145357|Dermacoccaceae	201174|Actinobacteria	P	ABC transporter	ylmA	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
k59_519929_1	686578.AFFX01000003_gene237	6.16e-11	67.4	COG3900@1|root,COG3900@2|Bacteria,1RKQP@1224|Proteobacteria,1SB83@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
k59_699015_1	471853.Bcav_1208	2.77e-37	142.0	COG3147@1|root,COG3147@2|Bacteria,2HC8A@201174|Actinobacteria	201174|Actinobacteria	S	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1637828_1	317025.Tcr_1321	2.02e-88	268.0	COG2020@1|root,COG2020@2|Bacteria,1R7G6@1224|Proteobacteria,1S9RT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_1637828_2	66874.JOFS01000055_gene1727	9.4e-23	100.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1162623_1	446469.Sked_18300	3.31e-68	232.0	COG1038@1|root,COG1038@2|Bacteria,2H238@201174|Actinobacteria	201174|Actinobacteria	C	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second	pyc	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA
k59_1754688_1	1247963.JPHU01000005_gene350	9.63e-10	58.2	COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,2U7UT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG2111 Multisubunit Na H antiporter, MnhB subunit	-	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040
k59_1754688_2	1198232.CYCME_1786	2.16e-31	114.0	COG1320@1|root,COG1320@2|Bacteria,1PC9X@1224|Proteobacteria,1SX6D@1236|Gammaproteobacteria,4630V@72273|Thiotrichales	72273|Thiotrichales	P	Na+/H+ antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_1809479_2	1296990.H845_2502	3.42e-12	70.9	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,2JPW3@204441|Rhodospirillales	204441|Rhodospirillales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_1050314_2	768671.ThimaDRAFT_0077	6.29e-18	84.7	COG0526@1|root,COG0526@2|Bacteria,1MWDE@1224|Proteobacteria,1S0NV@1236|Gammaproteobacteria,1WXDD@135613|Chromatiales	135613|Chromatiales	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
k59_171989_1	314285.KT71_16791	2.87e-89	276.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1S01K@1236|Gammaproteobacteria,1J7W3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	L COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_1754696_2	570268.ANBB01000038_gene3334	1.73e-33	130.0	COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1228803_1	335283.Neut_0817	9.33e-40	137.0	COG4577@1|root,COG4577@2|Bacteria,1QG1Y@1224|Proteobacteria,2VPXA@28216|Betaproteobacteria	28216|Betaproteobacteria	CQ	microcompartments protein	-	-	-	-	-	-	-	-	-	-	-	-	BMC
k59_1228803_2	323098.Nwi_1973	5.45e-62	197.0	COG0265@1|root,COG0265@2|Bacteria,1R40X@1224|Proteobacteria,2UEZS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
k59_1403957_1	742823.HMPREF9465_00300	2.78e-100	310.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,4PQQW@995019|Sutterellaceae	28216|Betaproteobacteria	C	Fumarate reductase flavoprotein C-term	frdA	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_1809496_1	1265505.ATUG01000003_gene25	5.26e-74	239.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,42N93@68525|delta/epsilon subdivisions,2WJ9N@28221|Deltaproteobacteria,2MHX8@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,TrkA_C,Voltage_CLC
k59_1699066_1	395493.BegalDRAFT_1699	3.47e-158	461.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RR14@1236|Gammaproteobacteria,461Y7@72273|Thiotrichales	72273|Thiotrichales	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_1699067_1	1049564.TevJSym_ab00630	1.64e-119	355.0	COG0577@1|root,COG0577@2|Bacteria,1QRYR@1224|Proteobacteria,1S0ZU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	tagS	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
k59_758977_1	1089546.AQUI01000002_gene501	2.69e-09	58.5	COG0494@1|root,COG0494@2|Bacteria,2GN6D@201174|Actinobacteria,407I6@622450|Actinopolysporales	201174|Actinobacteria	L	NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_462678_1	1288079.AUKN01000014_gene547	3.34e-109	338.0	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria	201174|Actinobacteria	G	hydrolase, family 65, central catalytic	-	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0030312,GO:0044464,GO:0071944	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
k59_580063_2	903818.KI912269_gene259	2.6e-23	100.0	COG2864@1|root,COG2864@2|Bacteria,3Y6QW@57723|Acidobacteria	57723|Acidobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Ni_hydr_CYTB
k59_1463129_1	1056820.KB900633_gene2019	4.42e-11	68.9	COG1729@1|root,COG1729@2|Bacteria,1MX82@1224|Proteobacteria,1T32S@1236|Gammaproteobacteria,2PMTJ@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TPR_8
k59_877161_1	1380354.JIAN01000010_gene2987	9.94e-06	47.4	2D19V@1|root,334ZZ@2|Bacteria,2I39B@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_877161_2	1151122.AQYD01000007_gene801	6.53e-88	271.0	COG0569@1|root,COG0569@2|Bacteria,2I2I2@201174|Actinobacteria	201174|Actinobacteria	P	Ion transport protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,Ion_trans_2
k59_699067_2	1454010.JEOE01000013_gene2240	3.66e-41	141.0	28MMU@1|root,2ZAXG@2|Bacteria,2HAD5@201174|Actinobacteria,4F216@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_347218_1	414684.RC1_0463	7.58e-55	195.0	COG1629@1|root,COG4771@2|Bacteria,1N6JG@1224|Proteobacteria,2TSK9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Outer membrane receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
k59_806971_1	1049564.TevJSym_bn00150	9.23e-69	216.0	COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,1RQ7W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )	-	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6
k59_1050354_1	1333856.L686_05215	6.49e-47	169.0	COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,1RNJ3@1236|Gammaproteobacteria,1Z28Q@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	M	COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
k59_172036_1	1415779.JOMH01000001_gene184	1.59e-15	80.1	2EDVS@1|root,337QX@2|Bacteria,1NEZW@1224|Proteobacteria,1SJBI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_580084_2	159087.Daro_0531	2.04e-18	78.2	COG1917@1|root,COG1917@2|Bacteria,1N0MR@1224|Proteobacteria,2VVE1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2
k59_1162701_1	913325.N799_04080	1.19e-30	115.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,1RN6F@1236|Gammaproteobacteria,1X34D@135614|Xanthomonadales	135614|Xanthomonadales	C	electron transfer flavoprotein beta subunit	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
k59_1162701_2	402612.FP0248	7.4e-09	58.9	COG1162@1|root,COG1162@2|Bacteria,4NE5H@976|Bacteroidetes,1HX6Y@117743|Flavobacteriia,2NSI6@237|Flavobacterium	976|Bacteroidetes	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase,RsgA_N
k59_1463151_1	1005395.CSV86_00217	0.000708	40.4	COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria	1224|Proteobacteria	C	Nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
k59_1463151_2	536019.Mesop_6659	1.11e-36	134.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2U84H@28211|Alphaproteobacteria,43HAF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	PBP superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_519981_1	1123401.JHYQ01000006_gene148	9.65e-194	566.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,45ZPW@72273|Thiotrichales	72273|Thiotrichales	P	heavy metal translocating P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
k59_699104_2	1380394.JADL01000002_gene1165	4.76e-11	60.1	COG4321@1|root,COG4321@2|Bacteria,1N7Z2@1224|Proteobacteria,2UF7W@28211|Alphaproteobacteria,2JUIJ@204441|Rhodospirillales	204441|Rhodospirillales	S	Ribbon-helix-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	RHH_4
k59_1162713_1	1049564.TevJSym_ab00750	1.23e-43	155.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1J4E0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	-	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
k59_1162713_2	768671.ThimaDRAFT_1130	7.37e-11	60.8	29HVD@1|root,304SH@2|Bacteria,1RD9R@1224|Proteobacteria,1S46Q@1236|Gammaproteobacteria,1WY83@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_699107_1	1095767.CAHD01000130_gene1340	1.42e-48	167.0	COG1109@1|root,COG1109@2|Bacteria,2GN87@201174|Actinobacteria,4F0QY@85016|Cellulomonadaceae	201174|Actinobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	GO:0008150,GO:0040007	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_699107_2	471853.Bcav_3105	1.71e-12	63.9	COG0103@1|root,COG0103@2|Bacteria,2GNDY@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
k59_1699135_2	1394178.AWOO02000018_gene6569	1.75e-28	113.0	COG2267@1|root,COG2267@2|Bacteria,2GIVB@201174|Actinobacteria,4EFUF@85012|Streptosporangiales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
k59_1637888_1	1121405.dsmv_3228	2.7e-53	174.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,42N0I@68525|delta/epsilon subdivisions,2WMUX@28221|Deltaproteobacteria,2MJHY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
k59_172088_1	472759.Nhal_2277	1.75e-38	139.0	COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,1T1Q3@1236|Gammaproteobacteria,1WXCI@135613|Chromatiales	135613|Chromatiales	P	PFAM periplasmic solute binding protein	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
k59_1162730_1	469383.Cwoe_0664	1.5e-37	130.0	COG0251@1|root,COG0251@2|Bacteria,2IFCR@201174|Actinobacteria,4CSQ3@84995|Rubrobacteria	84995|Rubrobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_1162730_2	713586.KB900536_gene1925	1.33e-92	294.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1WW2Y@135613|Chromatiales	135613|Chromatiales	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_1050424_1	1168034.FH5T_19750	1.35e-71	229.0	COG0527@1|root,COG0527@2|Bacteria,4PKFA@976|Bacteroidetes,2G3F2@200643|Bacteroidia	976|Bacteroidetes	E	Amino acid kinase family	-	-	1.1.1.3,2.7.2.4	ko:K00928,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_1177459_2	1094980.Mpsy_2291	3.75e-11	63.9	COG1266@1|root,arCOG02768@2157|Archaea,2XZ3X@28890|Euryarchaeota,2NAUF@224756|Methanomicrobia	224756|Methanomicrobia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
k59_1647310_1	1123367.C666_07640	3.58e-32	131.0	COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,2VKA1@28216|Betaproteobacteria,2KUHM@206389|Rhodocyclales	206389|Rhodocyclales	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
k59_297029_1	1120951.AUBG01000001_gene858	9.92e-72	233.0	COG0364@1|root,COG0364@2|Bacteria,4NE59@976|Bacteroidetes,1HWVJ@117743|Flavobacteriia	976|Bacteroidetes	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
k59_1118413_1	313628.LNTAR_25330	7.91e-25	105.0	COG1349@1|root,COG1349@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	3.6.4.12	ko:K02444,ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	AlbA_2,DUF1670,DeoRC,HATPase_c_4,HTH_DeoR
k59_4564_1	1328313.DS2_03655	6.02e-65	211.0	COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,1RPS3@1236|Gammaproteobacteria,4656V@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
k59_766145_1	644801.Psest_0540	3.77e-45	155.0	COG1226@1|root,2Z7ZD@2|Bacteria,1MXKM@1224|Proteobacteria,1RNMT@1236|Gammaproteobacteria,1Z2PI@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	U	Polycystin cation channel	-	-	-	ko:K08714	-	-	-	-	ko00000,ko02000	1.A.1.14	-	-	Ion_trans
k59_531793_1	95619.PM1_0216130	2.26e-61	199.0	COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,1RMYN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_63925_1	402777.KB235904_gene4764	3.63e-18	87.0	COG4886@1|root,COG4886@2|Bacteria,1G0NZ@1117|Cyanobacteria,1HBAM@1150|Oscillatoriales	1117|Cyanobacteria	S	Leucine-rich repeat (LRR) protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_357438_1	1196095.GAPWK_0772	7.44e-23	102.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006869,GO:0008144,GO:0008150,GO:0008289,GO:0008559,GO:0009987,GO:0010876,GO:0015221,GO:0015238,GO:0015399,GO:0015405,GO:0015437,GO:0015893,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034040,GO:0034204,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0071702,GO:0071840,GO:0071944,GO:0097035,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	iJN746.PP_4935,iPC815.YPO1395,iUMN146_1321.UM146_12980	ABC_membrane,ABC_tran
k59_179472_1	909663.KI867151_gene3077	4.64e-20	95.5	COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,42MUS@68525|delta/epsilon subdivisions,2WKK4@28221|Deltaproteobacteria,2MRM4@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	homolog of phage Mu protein gp47	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
k59_120878_1	298654.FraEuI1c_0261	5.33e-16	83.2	COG5412@1|root,COG5412@2|Bacteria	2|Bacteria	N	phage tail tape measure protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_238601_1	236097.ADG881_2509	1.25e-26	111.0	COG0491@1|root,COG0491@2|Bacteria,1MUXF@1224|Proteobacteria,1RP5I@1236|Gammaproteobacteria,1XJW5@135619|Oceanospirillales	135619|Oceanospirillales	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_238601_2	472759.Nhal_3897	2.93e-53	184.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1WWSQ@135613|Chromatiales	135613|Chromatiales	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
k59_1236264_1	765912.Thimo_3522	1.66e-60	192.0	COG4067@1|root,COG4067@2|Bacteria,1RGX8@1224|Proteobacteria,1S5YR@1236|Gammaproteobacteria,1WYD4@135613|Chromatiales	135613|Chromatiales	O	Putative ATP-dependant zinc protease	-	-	-	-	-	-	-	-	-	-	-	-	Zn_protease
k59_885781_1	1172188.KB911820_gene2666	7.73e-52	174.0	arCOG13016@1|root,335CN@2|Bacteria,2GJJU@201174|Actinobacteria,4FFGN@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_179481_1	631362.Thi970DRAFT_03550	1.61e-37	138.0	COG4589@1|root,COG4589@2|Bacteria,1R34Q@1224|Proteobacteria,1T63B@1236|Gammaproteobacteria,1WWNK@135613|Chromatiales	135613|Chromatiales	S	Belongs to the CDS family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
k59_179481_2	349521.HCH_05246	3.71e-08	53.9	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,1XIA5@135619|Oceanospirillales	135619|Oceanospirillales	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_944595_1	1122201.AUAZ01000009_gene2878	8.54e-81	266.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D9@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_1001052_1	1122614.JHZF01000011_gene2238	3.33e-92	288.0	COG0747@1|root,COG0747@2|Bacteria,1PF3V@1224|Proteobacteria,2V9MF@28211|Alphaproteobacteria,2PFP8@252301|Oceanicola	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
k59_944600_1	1267005.KB911258_gene394	1.8e-84	266.0	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,2TUSJ@28211|Alphaproteobacteria,3N61U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
k59_590597_1	1121396.KB893012_gene4039	1.12e-98	299.0	COG1148@1|root,COG1148@2|Bacteria,1R99M@1224|Proteobacteria,42Q2T@68525|delta/epsilon subdivisions,2WJTB@28221|Deltaproteobacteria,2MMH6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Pyr_redox_2
k59_297066_1	1089550.ATTH01000001_gene2120	1.57e-21	98.6	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,4NEP3@976|Bacteroidetes,1FIWT@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Pyruvate:ferredoxin oxidoreductase core domain II	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_766175_1	1384056.N787_13160	9.56e-40	143.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,1RM84@1236|Gammaproteobacteria,1X3RU@135614|Xanthomonadales	135614|Xanthomonadales	E	lysine 2,3-aminomutase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
k59_63960_1	1384056.N787_00245	2.12e-154	444.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1X2ZD@135614|Xanthomonadales	135614|Xanthomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_357479_1	46429.BV95_01551	3.9e-139	404.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,2K67G@204457|Sphingomonadales	204457|Sphingomonadales	L	MULE transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_1647357_1	367299.JOEE01000011_gene3190	3.62e-78	251.0	COG0747@1|root,COG0747@2|Bacteria,2GJXH@201174|Actinobacteria,4FEG1@85021|Intrasporangiaceae	201174|Actinobacteria	E	ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_885812_1	367299.JOEE01000007_gene210	7.31e-57	184.0	COG1309@1|root,COG1309@2|Bacteria,2GMBW@201174|Actinobacteria,4FF8T@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	icaR	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_1236286_1	765913.ThidrDRAFT_2114	6.04e-34	122.0	COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,1WXC6@135613|Chromatiales	135613|Chromatiales	S	integral membrane protein	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
k59_1236286_2	713586.KB900536_gene1710	1.27e-99	299.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,1WWVS@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
k59_1296868_1	13035.Dacsa_2625	3.39e-30	123.0	COG3210@1|root,COG3595@1|root,COG4070@1|root,COG3210@2|Bacteria,COG3595@2|Bacteria,COG4070@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	ko:K15125,ko:K20276	ko02024,ko05133,map02024,map05133	-	-	-	ko00000,ko00001,ko00536	-	-	-	CHU_C,DUF4097,FG-GAP_2,Glug,Haemagg_act,Laminin_G_3,PA14,SprB
k59_1470962_1	161528.ED21_24511	8.31e-81	260.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,2TRZV@28211|Alphaproteobacteria,2K46G@204457|Sphingomonadales	204457|Sphingomonadales	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
k59_531839_1	439235.Dalk_2275	9.48e-125	362.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42MI0@68525|delta/epsilon subdivisions,2WIW4@28221|Deltaproteobacteria,2MJ8Z@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Hydrogenase (NiFe) small subunit HydA	hydA	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.12.2.1,1.12.5.1,1.12.7.2,1.12.99.6	ko:K00534,ko:K05927,ko:K06282,ko:K18008	ko00633,ko01120,map00633,map01120	-	R00019,R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal
k59_824990_1	1267005.KB911255_gene2995	2.42e-84	264.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TR1W@28211|Alphaproteobacteria,3N6IU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	FP	Ppx/GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
k59_766187_1	1249627.D779_2669	2.91e-121	374.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria,1WXMT@135613|Chromatiales	135613|Chromatiales	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k59_1824968_1	1283300.ATXB01000001_gene1566	3.52e-17	84.0	COG0711@1|root,COG0711@2|Bacteria,1R6C0@1224|Proteobacteria,1S4NA@1236|Gammaproteobacteria,1XFA4@135618|Methylococcales	135618|Methylococcales	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,OSCP
k59_1824968_2	1415778.JQMM01000001_gene2181	7.32e-19	85.9	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1J5DU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA1	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_473066_1	1286631.X805_11390	1.76e-59	199.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VJK2@28216|Betaproteobacteria,1KPCZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_16,TPR_19,TPR_8
k59_1529562_1	1267005.KB911256_gene1990	3.14e-11	63.2	COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2U5DW@28211|Alphaproteobacteria,3N8U2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_649213_1	446471.Xcel_1327	1.13e-122	359.0	COG0002@1|root,COG0002@2|Bacteria,2GKQK@201174|Actinobacteria,4F3EW@85017|Promicromonosporaceae	201174|Actinobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0097159,GO:1901265,GO:1901363	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_649213_2	1115803.HMPREF1129_1644	5.14e-21	90.9	COG1364@1|root,COG1364@2|Bacteria,2GIW0@201174|Actinobacteria,4D4GJ@85005|Actinomycetales	201174|Actinobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
k59_4659_1	187272.Mlg_2086	1.6e-163	486.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_707990_1	439235.Dalk_4622	2.75e-76	250.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2MIW3@213118|Desulfobacterales	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
k59_1824992_1	1173023.KE650771_gene3680	4.01e-90	278.0	COG0787@1|root,COG0787@2|Bacteria,1GCYU@1117|Cyanobacteria,1JMVV@1189|Stigonemataceae	1117|Cyanobacteria	M	Alanine racemase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_1412389_1	314345.SPV1_04928	4.71e-128	397.0	28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria	1224|Proteobacteria	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
k59_414191_1	1499686.BN1079_02112	4.29e-52	173.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_590647_2	396588.Tgr7_0007	6.19e-33	120.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1WWV1@135613|Chromatiales	135613|Chromatiales	L	PFAM Endonuclease Exonuclease phosphatase	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_473090_1	1144319.PMI16_01767	6.1e-83	258.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VISA@28216|Betaproteobacteria,473PD@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Glycolate oxidase, iron-sulfur subunit	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7,Fer4_8
k59_179540_1	765123.HMPREF9621_00682	2.45e-89	271.0	COG0039@1|root,COG0039@2|Bacteria,2GN5S@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the LDH MDH superfamily. LDH family	ldh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
k59_885873_1	76869.PputGB1_1330	1.96e-42	152.0	COG2267@1|root,COG2267@2|Bacteria,1MX2H@1224|Proteobacteria,1RRSX@1236|Gammaproteobacteria,1YUVZ@136845|Pseudomonas putida group	1236|Gammaproteobacteria	I	serine threonine protein kinase	IV02_22745	-	-	-	-	-	-	-	-	-	-	-	-
k59_885873_2	1319815.HMPREF0202_00277	0.000389	45.1	COG2853@1|root,COG2853@2|Bacteria,37A72@32066|Fusobacteria	32066|Fusobacteria	M	VacJ-like protein	-	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
k59_708002_1	717785.HYPMC_0536	2.84e-119	366.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2TSZ9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,Transketolase_N
k59_179546_1	2340.JV46_03220	3.61e-36	132.0	COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,1RYFC@1236|Gammaproteobacteria,1J6QH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	HPP family	-	-	-	ko:K07168	-	-	-	-	ko00000	-	-	-	HPP
k59_120962_1	1123371.ATXH01000006_gene877	6.63e-23	96.7	COG1847@1|root,COG1847@2|Bacteria,2GGU8@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Jag_N	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,R3H
k59_120962_2	335543.Sfum_2597	3.73e-27	109.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria,2MQBM@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_944709_1	1232437.KL662064_gene4023	1.76e-108	323.0	COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,42NI3@68525|delta/epsilon subdivisions,2WJ6P@28221|Deltaproteobacteria,2MHUH@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
k59_1177555_1	349521.HCH_02594	9.6e-33	130.0	COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,1RNKG@1236|Gammaproteobacteria,1XNC8@135619|Oceanospirillales	135619|Oceanospirillales	U	COG0823 Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	PD40
k59_4698_1	398525.KB900701_gene1186	2.21e-56	187.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2TRAA@28211|Alphaproteobacteria,3JSQM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Tyrosine recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_1588173_1	1380354.JIAN01000006_gene674	3.58e-106	332.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4F0DB@85016|Cellulomonadaceae	201174|Actinobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_179566_1	1246995.AFR_19390	5.91e-66	217.0	COG2182@1|root,COG2182@2|Bacteria,2HU1V@201174|Actinobacteria,4DAF2@85008|Micromonosporales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K15770	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	SBP_bac_8
k59_708628_1	926560.KE387023_gene2409	1.21e-32	122.0	COG1985@1|root,COG1985@2|Bacteria	2|Bacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	MA20_21040	-	1.1.1.193,1.1.1.302,3.5.4.26	ko:K00082,ko:K11752,ko:K14654	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459,R09375,R09376	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C
k59_5515_1	1216966.BAUC01000013_gene326	3.18e-91	278.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iSFV_1184.SFV_0382	AIRS,AIRS_C
k59_180240_1	933262.AXAM01000003_gene2792	2.33e-156	453.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MHQQ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the peptidase S1C family	degP	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_945734_1	452637.Oter_1788	6.49e-67	226.0	COG0209@1|root,COG0209@2|Bacteria,46XFZ@74201|Verrucomicrobia,3K76W@414999|Opitutae	414999|Opitutae	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	-
k59_414848_1	44060.JODL01000031_gene1728	4.63e-34	130.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria	201174|Actinobacteria	G	alpha amylase, catalytic	malL	-	3.2.1.10	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R01718,R01791,R06199	RC00028,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3459,Malt_amylase_C
k59_414848_2	1197706.AKKK01000047_gene3292	1.11e-45	165.0	COG1940@1|root,COG1940@2|Bacteria,2GNFJ@201174|Actinobacteria	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,ROK
k59_65091_1	1380380.JIAX01000006_gene1029	3.71e-33	127.0	COG4949@1|root,COG4949@2|Bacteria,1MVI2@1224|Proteobacteria,2TSQJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane-anchored protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3422
k59_945742_1	321955.AAGP01000005_gene66	3.01e-18	83.2	COG0251@1|root,COG0251@2|Bacteria,2IHNE@201174|Actinobacteria,4F9WU@85019|Brevibacteriaceae	201174|Actinobacteria	J	YjgF/chorismate_mutase-like, putative endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
k59_945742_2	1500257.JQNM01000004_gene415	2.59e-27	110.0	COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2TRM2@28211|Alphaproteobacteria,4BAZT@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
k59_1237056_1	1385520.N802_13830	4.85e-115	361.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4FE3D@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA-directed DNA polymerase	dnaE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_649932_1	479433.Caci_7041	7.07e-130	385.0	COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_358602_1	765912.Thimo_0427	7.8e-26	110.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1WWI2@135613|Chromatiales	135613|Chromatiales	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_358602_2	631362.Thi970DRAFT_02306	6.13e-30	117.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1WWI5@135613|Chromatiales	135613|Chromatiales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_1471747_1	933262.AXAM01000019_gene1098	1.18e-64	200.0	COG2131@1|root,COG2131@2|Bacteria,1RD1P@1224|Proteobacteria,42RHI@68525|delta/epsilon subdivisions,2WNGV@28221|Deltaproteobacteria,2MJGN@213118|Desulfobacterales	28221|Deltaproteobacteria	F	PFAM CMP dCMP deaminase zinc-binding	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
k59_1471747_2	1121405.dsmv_1588	1.01e-44	148.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,42SJP@68525|delta/epsilon subdivisions,2WPK0@28221|Deltaproteobacteria,2MJT3@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
k59_239469_1	1121405.dsmv_1784	0.0	2011.0	COG1204@1|root,COG1204@2|Bacteria,1MW4Z@1224|Proteobacteria,42TK8@68525|delta/epsilon subdivisions,2WQUX@28221|Deltaproteobacteria,2MPB3@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,Helicase_C
k59_239469_3	1121405.dsmv_1785	3.69e-195	548.0	2CE5F@1|root,2Z7YQ@2|Bacteria,1MXVM@1224|Proteobacteria,42Q53@68525|delta/epsilon subdivisions,2WJY4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_766777_2	562973.HMPREF0059_00470	1.3e-67	238.0	COG5479@1|root,COG5479@2|Bacteria,2GNDB@201174|Actinobacteria,4D3RQ@85005|Actinomycetales	201174|Actinobacteria	M	N-acetylmuramoyl-L-alanine amidase	csp	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,LGFP
k59_825732_1	1121405.dsmv_2914	1.16e-91	283.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MI07@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	ko:K02481,ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1764977_1	1191523.MROS_1441	3.21e-26	106.0	2AMSR@1|root,31CP7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1178229_1	1429916.X566_09605	1.35e-69	225.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2TRMY@28211|Alphaproteobacteria,3JTQW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_1413129_1	1479237.JMLY01000001_gene658	6.06e-52	169.0	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,1RMQ2@1236|Gammaproteobacteria,466CT@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	GO:0000166,GO:0003674,GO:0003824,GO:0004733,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009443,GO:0009987,GO:0010181,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019842,GO:0032553,GO:0032991,GO:0034641,GO:0036094,GO:0042301,GO:0042364,GO:0042802,GO:0042803,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043094,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902444	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
k59_1001672_1	981384.AEYW01000022_gene3728	8.34e-101	309.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_536974_1	1273125.Rrhod_4361	4.59e-21	85.5	29XJ6@1|root,30JA6@2|Bacteria,2GWVQ@201174|Actinobacteria,4G5A0@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_302028_1	1049564.TevJSym_ab00710	1.44e-58	188.0	COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,1S4UH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
k59_302028_2	765913.ThidrDRAFT_0745	5.66e-147	419.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1WWV1@135613|Chromatiales	135613|Chromatiales	L	PFAM Endonuclease Exonuclease phosphatase	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_302028_3	697282.Mettu_4288	2.74e-32	117.0	COG2138@1|root,COG2138@2|Bacteria,1N00J@1224|Proteobacteria,1SEQ6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	CbiX	cbiX	-	4.99.1.4	ko:K03794	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R02864	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	CbiX
k59_1182965_1	1146883.BLASA_0434	9.94e-51	175.0	COG2801@1|root,COG2801@2|Bacteria,2I8Z0@201174|Actinobacteria,4EV5E@85013|Frankiales	201174|Actinobacteria	L	Integrase, catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_892982_1	1049564.TevJSym_an00130	6.32e-69	219.0	COG2981@1|root,COG2981@2|Bacteria,1MVFT@1224|Proteobacteria,1RMQT@1236|Gammaproteobacteria,1J5RJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway	cysZ	GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0008150,GO:0008152,GO:0008271,GO:0008272,GO:0008324,GO:0008509,GO:0008512,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009675,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015103,GO:0015116,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015296,GO:0015318,GO:0015672,GO:0015698,GO:0016020,GO:0016021,GO:0016053,GO:0019344,GO:0019752,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044425,GO:0044459,GO:0044464,GO:0046394,GO:0051179,GO:0051234,GO:0055085,GO:0071704,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:0098660,GO:0098661,GO:0098662,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901682,GO:1902358,GO:1902600	-	ko:K06203	-	-	-	-	ko00000	-	-	iJR904.b2413,iYL1228.KPN_02760	EI24
k59_892982_2	1249627.D779_1641	9.13e-39	141.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,1RR7X@1236|Gammaproteobacteria,1WW9A@135613|Chromatiales	135613|Chromatiales	G	PFAM carbohydrate kinase	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
k59_1358614_1	713586.KB900536_gene366	3.07e-84	258.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,1WWPU@135613|Chromatiales	135613|Chromatiales	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_419312_1	1306174.JODP01000003_gene2171	1.88e-40	159.0	COG1226@1|root,COG1226@2|Bacteria,2GKPB@201174|Actinobacteria	201174|Actinobacteria	P	Castor and Pollux, part of voltage-gated ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Castor_Poll_mid,TrkA_N
k59_770402_1	367299.JOEE01000007_gene49	4.21e-108	330.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4FE8A@85021|Intrasporangiaceae	201174|Actinobacteria	EQ	Hydantoinase	hyuB	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
k59_1182974_1	870187.Thini_3018	9.55e-90	285.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,45ZXP@72273|Thiotrichales	72273|Thiotrichales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_1652776_1	1304865.JAGF01000001_gene2477	7.83e-89	294.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,COG1145@2|Bacteria,2I995@201174|Actinobacteria	201174|Actinobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_951995_1	1121441.AUCX01000003_gene3010	1.69e-65	226.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2WITS@28221|Deltaproteobacteria,2M889@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,PurS
k59_1182975_1	525246.HMPREF0058_0917	3.79e-59	199.0	COG0534@1|root,COG0534@2|Bacteria,2GJE3@201174|Actinobacteria,4D38K@85005|Actinomycetales	201174|Actinobacteria	V	MATE efflux family protein	dinF	-	-	-	-	-	-	-	-	-	-	-	MatE
k59_713222_1	471853.Bcav_1274	1.41e-143	442.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase E1 component	kgd	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1248c	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_892997_1	1323663.AROI01000009_gene3412	6.66e-17	84.7	COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,1RRGY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
k59_1652780_1	439235.Dalk_1595	2.61e-78	248.0	COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,42P7C@68525|delta/epsilon subdivisions,2WKKF@28221|Deltaproteobacteria,2MIJE@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM MltA	-	-	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	-	3D,MltA
k59_537001_1	349521.HCH_01427	1.01e-33	130.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XIXB@135619|Oceanospirillales	135619|Oceanospirillales	T	With GlrK is part of a two-component signal transduction system regulating glmY	-	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Sigma54_activat
k59_654536_1	880072.Desac_0433	5.91e-22	94.4	COG0589@1|root,COG0589@2|Bacteria,1N6DC@1224|Proteobacteria,42UXA@68525|delta/epsilon subdivisions,2WQF5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_364764_1	290512.Paes_2083	7.38e-178	513.0	COG0069@1|root,COG4638@1|root,COG0069@2|Bacteria,COG4638@2|Bacteria,1FDGS@1090|Chlorobi	1090|Chlorobi	C	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase,Rieske
k59_713230_1	1267005.KB911263_gene1272	1.89e-53	169.0	COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,2U97J@28211|Alphaproteobacteria,3N745@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	ferredoxin	fdx	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
k59_1710648_1	367299.JOEE01000005_gene3565	8.21e-79	239.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4FF9V@85021|Intrasporangiaceae	201174|Actinobacteria	E	COG0410 ABC-type branched-chain amino acid transport systems, ATPase component	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_1710648_2	367299.JOEE01000005_gene3566	3.29e-13	67.8	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4FFTD@85021|Intrasporangiaceae	201174|Actinobacteria	E	COG0411 ABC-type branched-chain amino acid transport systems ATPase component	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
k59_537003_1	395494.Galf_0210	8.07e-36	139.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VJ86@28216|Betaproteobacteria,44VD5@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
k59_1418821_1	368407.Memar_0608	1.05e-56	182.0	COG4063@1|root,arCOG03221@2157|Archaea,2XWSE@28890|Euryarchaeota,2N9GK@224756|Methanomicrobia	224756|Methanomicrobia	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step	mtrA-1	-	2.1.1.86	ko:K00577	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrA
k59_1418821_2	521011.Mpal_2315	1.75e-13	64.7	COG4218@1|root,arCOG03381@2157|Archaea,2Y1CV@28890|Euryarchaeota,2NA36@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM tetrahydromethanopterin S-methyltransferase, F subunit	-	-	2.1.1.86	ko:K00582	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrF
k59_1123391_1	159087.Daro_0678	8.43e-32	118.0	COG1392@1|root,COG1392@2|Bacteria,1NDTG@1224|Proteobacteria,2VJ5F@28216|Betaproteobacteria,2KVDV@206389|Rhodocyclales	206389|Rhodocyclales	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_1305337_1	156889.Mmc1_3257	7.26e-12	68.2	28T0P@1|root,2ZF9Z@2|Bacteria,1RAUV@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_596185_1	1229781.C272_15782	1.36e-16	80.9	COG0160@1|root,COG0160@2|Bacteria,2I2F3@201174|Actinobacteria,4F9EP@85019|Brevibacteriaceae	201174|Actinobacteria	E	Aminotransferase class-III	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
k59_1068674_1	159087.Daro_0979	7.58e-105	321.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VHW2@28216|Betaproteobacteria,2KUYG@206389|Rhodocyclales	206389|Rhodocyclales	C	Respiratory-chain NADH dehydrogenase	hoxF	-	1.12.1.2	ko:K18005	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
k59_1479241_1	948106.AWZT01000031_gene1306	8.34e-24	98.6	COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,2VN8Q@28216|Betaproteobacteria,1K0IY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
k59_1535296_1	76114.ebA4143	1.67e-27	105.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2VKZV@28216|Betaproteobacteria,2KV74@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the BI1 family	-	-	-	ko:K19416	-	M00742	-	-	ko00000,ko00002,ko02000	1.A.14.2.1	-	-	Bax1-I
k59_894148_1	933262.AXAM01000020_gene26	1e-67	226.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2WJTT@28221|Deltaproteobacteria,2MITA@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
k59_72433_1	1049564.TevJSym_bb00350	1.56e-57	181.0	COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria,1S8RW@1236|Gammaproteobacteria,1JBM2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
k59_365934_1	1217656.F964_00209	1.11e-81	259.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria,3NK5D@468|Moraxellaceae	1236|Gammaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
k59_127138_1	1458427.BAWN01000018_gene1140	5.69e-50	171.0	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,2VJ62@28216|Betaproteobacteria,4ACES@80864|Comamonadaceae	28216|Betaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_72439_1	452637.Oter_4289	2.23e-57	196.0	COG3507@1|root,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	xynBA	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
k59_1183840_1	1035308.AQYY01000001_gene3295	1.38e-225	646.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
k59_420109_1	760117.JN27_03185	1.93e-35	127.0	COG2761@1|root,COG2761@2|Bacteria,1RIE0@1224|Proteobacteria	1224|Proteobacteria	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
k59_420109_2	1379270.AUXF01000003_gene3720	2.52e-17	80.9	COG0332@1|root,COG0332@2|Bacteria,1ZUKB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_953166_1	864051.BurJ1DRAFT_0237	4.95e-08	54.3	COG3658@1|root,COG3658@2|Bacteria,1RB03@1224|Proteobacteria,2VQQ7@28216|Betaproteobacteria,1KKSE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome b/b6/petB	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
k59_953166_2	1049564.TevJSym_ae00860	1.2e-39	136.0	COG2010@1|root,COG2010@2|Bacteria,1N1Z3@1224|Proteobacteria,1S8J5@1236|Gammaproteobacteria,1JAXC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Domain of unknown function (DUF1924)	shp	-	-	-	-	-	-	-	-	-	-	-	DUF1924
k59_953166_3	1232683.ADIMK_0262	2.94e-46	157.0	COG3658@1|root,COG3658@2|Bacteria,1N28F@1224|Proteobacteria,1S2S2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	PFAM Di-haem cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	DHC
k59_1305358_1	272630.MexAM1_META1p5117	2.02e-37	137.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2TRWB@28211|Alphaproteobacteria,1JQPF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_1305358_2	1415780.JPOG01000001_gene2431	1.45e-44	150.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1X41Q@135614|Xanthomonadales	135614|Xanthomonadales	EH	with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine	trpG	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
k59_1006007_1	582899.Hden_1730	3.54e-63	207.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,2TV3E@28211|Alphaproteobacteria,3N73W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DNA polymerase III, delta subunit	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
k59_596209_1	395961.Cyan7425_2932	5.47e-07	50.1	2DMJE@1|root,32RYR@2|Bacteria,1G6SI@1117|Cyanobacteria,3KIJW@43988|Cyanothece	1117|Cyanobacteria	S	Domain of unknown function (DUF4112)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4112
k59_72461_1	765912.Thimo_2212	6.08e-116	350.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1WXXQ@135613|Chromatiales	135613|Chromatiales	G	Alpha amylase catalytic	-	-	2.4.1.7	ko:K00690	ko00500,map00500	-	R00803	RC00028	ko00000,ko00001,ko01000	-	GH13	-	-
k59_537798_1	1212548.B381_12246	1.98e-33	129.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1YZWM@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	T	signal transduction protein with a C-terminal ATPase domain	algZ	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
k59_15684_1	1123392.AQWL01000010_gene2312	1.14e-66	216.0	COG2211@1|root,COG2211@2|Bacteria,1QVH9@1224|Proteobacteria,2WGR7@28216|Betaproteobacteria,1KSBE@119069|Hydrogenophilales	119069|Hydrogenophilales	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_302849_1	1236959.BAMT01000001_gene1355	1.93e-19	93.6	COG2885@1|root,COG2885@2|Bacteria,1NQKJ@1224|Proteobacteria	1224|Proteobacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1123415_1	555778.Hneap_1898	5.86e-26	107.0	COG4395@1|root,COG4395@2|Bacteria,1NSUG@1224|Proteobacteria,1S5PI@1236|Gammaproteobacteria,1WYB8@135613|Chromatiales	135613|Chromatiales	S	Tim44	-	-	-	-	-	-	-	-	-	-	-	-	Tim44
k59_420126_1	1122201.AUAZ01000003_gene1873	1.04e-82	251.0	28JRZ@1|root,2Z9HI@2|Bacteria,1R52Z@1224|Proteobacteria,1RRWN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126,SHOCT
k59_302853_1	1128421.JAGA01000001_gene2203	1.16e-33	132.0	COG4579@1|root,COG4579@2|Bacteria	2|Bacteria	F	[isocitrate dehydrogenase (NADP+)] phosphatase activity	aceK	GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
k59_127164_1	710111.FraQA3DRAFT_3721	4.54e-99	313.0	COG0477@1|root,COG0477@2|Bacteria,2GJ09@201174|Actinobacteria,4ES1I@85013|Frankiales	201174|Actinobacteria	P	drug resistance transporter, EmrB QacA subfamily	-	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_1653659_1	1192034.CAP_0497	2.7e-41	149.0	COG1028@1|root,COG1028@2|Bacteria,1MWJQ@1224|Proteobacteria,433VV@68525|delta/epsilon subdivisions,2X3QJ@28221|Deltaproteobacteria,2YWUM@29|Myxococcales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_249328_1	1122604.JONR01000043_gene3175	1.77e-45	160.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1X31B@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_249328_2	1485544.JQKP01000002_gene1549	1.59e-13	70.5	COG2267@1|root,COG2267@2|Bacteria,1N2R9@1224|Proteobacteria,2VRME@28216|Betaproteobacteria,44VRK@713636|Nitrosomonadales	28216|Betaproteobacteria	I	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters	bioH	-	3.1.1.85	ko:K02170	ko00780,ko01100,map00780,map01100	M00572	R09725	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_1006021_1	153948.NAL212_0995	1.56e-29	107.0	2E0T4@1|root,32WAV@2|Bacteria,1N19Z@1224|Proteobacteria,2VTHM@28216|Betaproteobacteria,373HE@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1006021_2	1121035.AUCH01000019_gene2866	2e-19	86.7	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria,2KV2N@206389|Rhodocyclales	206389|Rhodocyclales	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM
k59_1833561_1	999611.KI421504_gene459	1.22e-12	66.6	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria,280JA@191028|Leisingera	28211|Alphaproteobacteria	IQ	KR domain	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_1833561_2	1267005.KB911255_gene2893	5.55e-90	272.0	COG0077@1|root,COG0077@2|Bacteria,1MU60@1224|Proteobacteria,2TSUT@28211|Alphaproteobacteria,3N6E4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	PDT
k59_714142_1	765912.Thimo_2527	1.62e-93	288.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,1WWYU@135613|Chromatiales	135613|Chromatiales	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
k59_1653669_1	1101190.ARWB01000001_gene3737	7.86e-10	60.8	COG1651@1|root,COG1651@2|Bacteria,1RFF4@1224|Proteobacteria,2U5BN@28211|Alphaproteobacteria,36Y74@31993|Methylocystaceae	28211|Alphaproteobacteria	O	Thioredoxin	MA20_42440	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
k59_1653669_2	1040986.ATYO01000005_gene6344	7.62e-42	141.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2U7A8@28211|Alphaproteobacteria,43JP2@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	gloA	GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
k59_1359387_1	102232.GLO73106DRAFT_00020370	1.2e-88	265.0	COG0426@1|root,COG0426@2|Bacteria	2|Bacteria	C	nitric oxide reductase activity	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Fer4,Lactamase_B
k59_1418880_1	686340.Metal_1029	8.06e-25	107.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1RZEA@1236|Gammaproteobacteria,1XE56@135618|Methylococcales	135618|Methylococcales	O	TIGRFAM Cytochrome c-type biogenesis protein CcmI	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	-
k59_185871_1	243365.CV_2697	1.19e-68	221.0	COG0312@1|root,COG0312@2|Bacteria,1NSH6@1224|Proteobacteria,2VJRT@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
k59_185871_2	243365.CV_2696	4.32e-07	52.0	COG0312@1|root,COG0312@2|Bacteria,1QM7I@1224|Proteobacteria,2VNXI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
k59_15756_1	519989.ECTPHS_02666	2.28e-79	247.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1WWZ0@135613|Chromatiales	135613|Chromatiales	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
k59_72498_1	935567.JAES01000003_gene190	2.89e-104	328.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1X3SP@135614|Xanthomonadales	135614|Xanthomonadales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_1305415_1	1123514.KB905899_gene853	8.9e-28	117.0	COG0642@1|root,COG2200@1|root,COG2200@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,460AD@72273|Thiotrichales	72273|Thiotrichales	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,NMT1,PAS,PAS_9,Response_reg
k59_15763_1	1292035.H476_2696	2.12e-26	111.0	COG1032@1|root,COG1032@2|Bacteria,1UYAF@1239|Firmicutes,24D1D@186801|Clostridia	186801|Clostridia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
k59_1006035_1	857087.Metme_3706	5.07e-49	174.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1S48Z@1236|Gammaproteobacteria,1XEJQ@135618|Methylococcales	135618|Methylococcales	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
k59_420152_1	1304865.JAGF01000001_gene3660	5.08e-115	343.0	COG0165@1|root,COG0165@2|Bacteria,2GJ2A@201174|Actinobacteria,4F1Z3@85016|Cellulomonadaceae	201174|Actinobacteria	E	Argininosuccinate lyase C-terminal	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_1653682_1	1121924.ATWH01000010_gene1017	1.14e-34	127.0	COG1985@1|root,COG1985@2|Bacteria,2GN2P@201174|Actinobacteria,4FNXN@85023|Microbacteriaceae	201174|Actinobacteria	H	RibD C-terminal domain	ribD	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_1359394_1	768671.ThimaDRAFT_2311	5.79e-28	105.0	COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,1SD8H@1236|Gammaproteobacteria,1WZ9J@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsB	-	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
k59_1359394_2	87626.PTD2_13064	4.05e-09	58.5	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria,2Q035@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050518,GO:0070567,GO:0071704,GO:1901576	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2747,iBWG_1329.BWG_2483,iEC55989_1330.EC55989_3019,iECDH10B_1368.ECDH10B_2915,iECDH1ME8569_1439.ECDH1ME8569_2657,iECIAI1_1343.ECIAI1_2848,iECO103_1326.ECO103_3289,iECO111_1330.ECO111_3471,iECO26_1355.ECO26_3816,iECSE_1348.ECSE_2999,iECW_1372.ECW_m2953,iEKO11_1354.EKO11_1022,iEcDH1_1363.EcDH1_0941,iEcE24377_1341.EcE24377A_3048,iEcHS_1320.EcHS_A2885,iEcolC_1368.EcolC_0965,iJO1366.b2747,iJR904.b2747,iPC815.YPO3361,iSBO_1134.SBO_2773,iSDY_1059.SDY_2946,iSSON_1240.SSON_2895,iSbBS512_1146.SbBS512_E3127,iUMNK88_1353.UMNK88_3422,iWFL_1372.ECW_m2953,iY75_1357.Y75_RS14300	IspD
k59_1479336_1	1415756.JQMY01000001_gene2538	1.17e-28	109.0	COG2825@1|root,COG2825@2|Bacteria,1MZ4B@1224|Proteobacteria,2UC2P@28211|Alphaproteobacteria,2PEKR@252301|Oceanicola	28211|Alphaproteobacteria	M	Outer membrane protein (OmpH-like)	-	-	-	-	-	-	-	-	-	-	-	-	OmpH
k59_1479336_2	388399.SSE37_04550	1.41e-12	63.9	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,2U7G4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
k59_894231_1	580332.Slit_0624	4.86e-28	112.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2VHX2@28216|Betaproteobacteria,44V69@713636|Nitrosomonadales	28216|Betaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_1773882_1	1304865.JAGF01000001_gene1450	7.39e-69	236.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,2GIT4@201174|Actinobacteria,4F1UH@85016|Cellulomonadaceae	201174|Actinobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	mrpA/mrpB	-	-	ko:K05565,ko:K14086	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
k59_959024_1	555778.Hneap_0499	5.3e-27	108.0	COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,1S0KH@1236|Gammaproteobacteria,1WX4D@135613|Chromatiales	135613|Chromatiales	O	PFAM protein-L-isoaspartate(D-aspartate) O-methyltransferase	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
k59_1597888_1	983917.RGE_32080	2.27e-45	161.0	COG0444@1|root,COG4608@1|root,COG0444@2|Bacteria,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2W19X@28216|Betaproteobacteria,1KJV7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_1597888_2	1231391.AMZF01000050_gene1033	8.13e-10	60.1	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2VHWM@28216|Betaproteobacteria,3T309@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	oppC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1839391_1	933262.AXAM01000005_gene2458	4.15e-123	367.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,42MPH@68525|delta/epsilon subdivisions,2WJHW@28221|Deltaproteobacteria,2MHPG@213118|Desulfobacterales	28221|Deltaproteobacteria	M	N-acetylmuramoyl-L-alanine amidase	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,TPR_6
k59_1009465_1	335543.Sfum_3531	3.79e-59	194.0	COG1150@1|root,COG2452@1|root,COG1150@2|Bacteria,COG2452@2|Bacteria,1QZ4H@1224|Proteobacteria,43CFH@68525|delta/epsilon subdivisions,2X7QJ@28221|Deltaproteobacteria,2MSKT@213462|Syntrophobacterales	2|Bacteria	C	TIGRFAM DNA binding domain, excisionase family	dld	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K16887,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_7,Fer4_8,HTH_17,MerR_1
k59_835539_1	1280692.AUJL01000002_gene2770	2.87e-64	216.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_9,PTS-HPr,Sigma54_activat
k59_306864_1	314285.KT71_12795	3.23e-102	310.0	COG0624@1|root,COG0624@2|Bacteria,1R96A@1224|Proteobacteria,1RSD6@1236|Gammaproteobacteria,1J8ZH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
k59_22601_1	471853.Bcav_2940	2.05e-96	293.0	COG0213@1|root,COG0213@2|Bacteria,2GJH5@201174|Actinobacteria	201174|Actinobacteria	F	phosphorylase	deoA	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
k59_1773891_1	1300345.LF41_2649	1.17e-58	201.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9I0@135614|Xanthomonadales	135614|Xanthomonadales	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1009472_1	945713.IALB_1969	4.55e-105	311.0	COG1023@1|root,COG1023@2|Bacteria	2|Bacteria	G	D-gluconate metabolic process	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
k59_1839411_1	3075.A0A087SPN0	2.26e-35	135.0	COG0002@1|root,KOG4354@2759|Eukaryota,37R6A@33090|Viridiplantae,34IQR@3041|Chlorophyta	3041|Chlorophyta	E	Semialdehyde dehydrogenase, NAD binding domain	-	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_371791_1	1026882.MAMP_01282	7.86e-88	269.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1RWC8@1236|Gammaproteobacteria,460AJ@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	LeuA_dimer,PALP
k59_1009476_1	452637.Oter_4539	4.06e-45	155.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
k59_1009476_2	1396141.BATP01000001_gene5359	2.69e-50	177.0	COG0296@1|root,COG0596@1|root,COG2382@1|root,COG0296@2|Bacteria,COG0596@2|Bacteria,COG2382@2|Bacteria,46UH3@74201|Verrucomicrobia,2IUBH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	-	-	-	-	-	-	-	-	-	-	-	-	CBM_48,Esterase
k59_22618_1	99598.Cal7507_4444	1.88e-62	212.0	COG0491@1|root,COG4529@1|root,COG0491@2|Bacteria,COG4529@2|Bacteria,1G0CZ@1117|Cyanobacteria,1HMAK@1161|Nostocales	1117|Cyanobacteria	S	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,NAD_binding_9
k59_1839418_1	1249627.D779_2570	1.42e-111	331.0	COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,1RQ7I@1236|Gammaproteobacteria,1WWFP@135613|Chromatiales	135613|Chromatiales	L	PFAM integrase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve
k59_1188240_1	1108045.GORHZ_225_00200	8.61e-46	163.0	29K36@1|root,3070J@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
k59_131514_1	1437882.AZRU01000026_gene5971	1.59e-87	268.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,1YD08@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispA	GO:0003674,GO:0003824,GO:0004161,GO:0004337,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033383,GO:0033384,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045337,GO:0045338,GO:0071704,GO:0090407,GO:1901576	2.5.1.1,2.5.1.10,2.5.1.29	ko:K00795,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iPC815.YPO3176,iSFV_1184.SFV_0386	polyprenyl_synt
k59_1773903_1	1049564.TevJSym_at00760	2.23e-152	442.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1J5F2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1485293_2	880072.Desac_1284	1.13e-77	251.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,42P5Y@68525|delta/epsilon subdivisions,2WJEH@28221|Deltaproteobacteria,2MQ9X@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Transport of potassium into the cell	kup	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
k59_78236_1	572477.Alvin_1387	3.42e-171	489.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1WWEM@135613|Chromatiales	135613|Chromatiales	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_1773909_1	861299.J421_0464	5e-23	102.0	COG0793@1|root,COG0793@2|Bacteria,1ZT92@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	tail specific protease	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
k59_959067_1	1121918.ARWE01000001_gene964	1.73e-63	206.0	COG1638@1|root,COG1638@2|Bacteria,1PJFW@1224|Proteobacteria,42PXK@68525|delta/epsilon subdivisions,2WJFU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM TRAP dicarboxylate transporter- DctP subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1423242_1	1047013.AQSP01000133_gene2121	1.42e-106	316.0	COG0468@1|root,COG0468@2|Bacteria,2NNYW@2323|unclassified Bacteria	2|Bacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_483177_1	367299.JOEE01000004_gene1202	2.18e-71	227.0	COG2010@1|root,COG2010@2|Bacteria,2GN1Q@201174|Actinobacteria,4FESY@85021|Intrasporangiaceae	201174|Actinobacteria	C	Copper type II ascorbate-dependent monooxygenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Cu2_monoox_C,Cu2_monooxygen
k59_900090_1	1163617.SCD_n02176	2.98e-36	125.0	2DNV8@1|root,32ZAX@2|Bacteria,1R3MW@1224|Proteobacteria,2VWAR@28216|Betaproteobacteria	28216|Betaproteobacteria	S	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
k59_900090_2	1323663.AROI01000016_gene287	6.35e-24	98.6	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,1RNVM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the pirin family	XCC2717	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
k59_1539593_1	1239962.C943_00084	6.73e-129	405.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1141@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1141@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,4NF4F@976|Bacteroidetes	976|Bacteroidetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1075719_1	765911.Thivi_2319	5.25e-43	153.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1WWB9@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_774548_1	266117.Rxyl_1341	1.6e-15	74.7	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4CU5Y@84995|Rubrobacteria	84995|Rubrobacteria	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k59_306909_1	1121937.AUHJ01000021_gene1432	8.67e-88	268.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,46BKC@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_78262_1	862751.SACTE_2914	1.22e-51	174.0	COG3293@1|root,COG3293@2|Bacteria,2IIMK@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2,DUF4096
k59_835580_1	1121405.dsmv_1984	1.96e-145	423.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria,2MJG3@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_1658063_1	1082933.MEA186_24120	3.21e-23	107.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43NVJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,HEAT_2,Rhodanese,TPR_16,TPR_19,TPR_8,TolB_N
k59_1075737_1	1335757.SPICUR_08290	7.67e-51	171.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1WWIK@135613|Chromatiales	135613|Chromatiales	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_1539604_1	595593.JREV01000036_gene3551	1e-06	55.8	COG2334@1|root,COG2334@2|Bacteria,2I8IC@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	APH
k59_256225_1	522306.CAP2UW1_2512	5.78e-37	133.0	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,2VKQX@28216|Betaproteobacteria	28216|Betaproteobacteria	C	PFAM Thiamine pyrophosphate	porB	-	1.2.1.58,1.2.7.1	ko:K00170,ko:K18356	ko00010,ko00020,ko00360,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00360,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R02450,R08034	RC00004,RC00250,RC02742,RC02833,RC02860	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_11,Fer4_6,TPP_enzyme_C
k59_256225_2	946483.Cenrod_0416	3.23e-21	93.2	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,2VJSA@28216|Betaproteobacteria,4AGBW@80864|Comamonadaceae	28216|Betaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_1250298_1	319795.Dgeo_1377	7.17e-21	92.4	COG1136@1|root,COG1136@2|Bacteria,1WI3W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	ABC-type antimicrobial peptide transport system, ATPase component	glnQ	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_22659_1	1283300.ATXB01000001_gene1084	1.18e-68	227.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,1XE6A@135618|Methylococcales	135618|Methylococcales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	COX15-CtaA,SRP54,SRP54_N
k59_900115_1	1268635.Loa_01510	5.08e-68	226.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1JCH1@118969|Legionellales	118969|Legionellales	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	yfcX	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_1658072_1	1267005.KB911256_gene2041	9.38e-86	269.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,3N6GJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_1773940_1	2340.JV46_22540	1.07e-155	464.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1J57N@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_1539610_1	765910.MARPU_12515	2.63e-26	106.0	COG3258@1|root,COG3258@2|Bacteria,1MZJW@1224|Proteobacteria,1S2EF@1236|Gammaproteobacteria,1WY2H@135613|Chromatiales	135613|Chromatiales	C	Protein of unknown function (DUF3365)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365
k59_1715511_1	519989.ECTPHS_11527	1.89e-53	186.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,1RR35@1236|Gammaproteobacteria,1WXAB@135613|Chromatiales	135613|Chromatiales	P	TrkA-N domain	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_N
k59_718467_2	870187.Thini_4292	9.35e-103	308.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,45ZNA@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
k59_1597952_1	313628.LNTAR_24656	3.35e-46	164.0	COG0516@1|root,COG0516@2|Bacteria	2|Bacteria	F	GMP reductase activity	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006183,GO:0006195,GO:0006204,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009125,GO:0009126,GO:0009127,GO:0009128,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009154,GO:0009156,GO:0009158,GO:0009161,GO:0009163,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009169,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009261,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046039,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027	CBS,IMPDH,NMO
k59_1423273_1	1226322.HMPREF1545_02590	1.13e-08	58.9	COG3090@1|root,COG3090@2|Bacteria,1VD6X@1239|Firmicutes,24QCX@186801|Clostridia,2N7CH@216572|Oscillospiraceae	186801|Clostridia	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_1363622_1	743718.Isova_0943	4.01e-76	239.0	COG0739@1|root,COG0739@2|Bacteria,2GKXN@201174|Actinobacteria,4F3WM@85017|Promicromonosporaceae	201174|Actinobacteria	M	heme binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_371868_1	1247726.MIM_c24300	1.88e-86	283.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,3T1XY@506|Alcaligenaceae	28216|Betaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_483215_1	999141.GME_13345	3.48e-57	186.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,1XH61@135619|Oceanospirillales	135619|Oceanospirillales	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_483215_2	472759.Nhal_2387	3.99e-38	130.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,1S8VX@1236|Gammaproteobacteria,1WZEK@135613|Chromatiales	135613|Chromatiales	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_483215_3	2340.JV46_07340	1.03e-145	416.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,1RMGR@1236|Gammaproteobacteria,1J4FI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_718478_1	1249627.D779_1098	8.72e-94	289.0	COG2244@1|root,COG2244@2|Bacteria,1R512@1224|Proteobacteria,1RZ0F@1236|Gammaproteobacteria,1WXMU@135613|Chromatiales	135613|Chromatiales	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
k59_659894_1	743718.Isova_0810	3.63e-49	169.0	COG0153@1|root,COG0153@2|Bacteria,2GJXI@201174|Actinobacteria,4F3NC@85017|Promicromonosporaceae	201174|Actinobacteria	H	Belongs to the GHMP kinase family. GalK subfamily	galK	-	2.7.1.6,2.7.7.12	ko:K00849,ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955,R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
k59_1188307_2	1049564.TevJSym_am00060	5.22e-83	261.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1J4KE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iJN746.PP_5285,iSBO_1134.SBO_3641	DFP,Flavoprotein
k59_306952_1	76114.ebA3077	6.71e-94	303.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,2KUNR@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
k59_78307_1	1123065.ATWL01000009_gene984	6.31e-280	796.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria	201174|Actinobacteria	M	penicillin-binding protein	pon1	-	-	-	-	-	-	-	-	-	-	-	PASTA,Transgly,Transpeptidase
k59_1311314_1	1123368.AUIS01000004_gene133	2.31e-17	76.3	COG1320@1|root,COG1320@2|Bacteria,1N75I@1224|Proteobacteria,1SCHB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	PFAM Na H antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_1311314_2	425104.Ssed_1394	1.04e-18	82.8	COG1563@1|root,COG1563@2|Bacteria,1N7YY@1224|Proteobacteria,1SHR3@1236|Gammaproteobacteria,2QE6E@267890|Shewanellaceae	1236|Gammaproteobacteria	P	Domain of unknown function (DUF4040)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4040
k59_1539632_1	367299.JOEE01000005_gene3452	1.62e-21	92.4	COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,4FE6Z@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_1539632_3	1151119.KB895491_gene1794	1.33e-05	45.1	COG4768@1|root,COG4768@2|Bacteria,2II1J@201174|Actinobacteria,1W9K6@1268|Micrococcaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF948)	-	-	-	-	-	-	-	-	-	-	-	-	DUF948
k59_1597969_1	395493.BegalDRAFT_1873	1.3e-38	136.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,46018@72273|Thiotrichales	72273|Thiotrichales	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
k59_1597969_2	472759.Nhal_3018	2.12e-64	202.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,1S6B5@1236|Gammaproteobacteria,1X2FV@135613|Chromatiales	135613|Chromatiales	S	Smr protein	-	-	-	-	-	-	-	-	-	-	-	-	Smr
k59_1597969_3	1123367.C666_17375	1.57e-17	82.8	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2VHNY@28216|Betaproteobacteria,2KU9T@206389|Rhodocyclales	206389|Rhodocyclales	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
k59_835631_1	590998.Celf_1530	7.27e-66	210.0	COG0195@1|root,COG0195@2|Bacteria,2GJDJ@201174|Actinobacteria,4F0JV@85016|Cellulomonadaceae	201174|Actinobacteria	K	Participates in both transcription termination and antitermination	nusA	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0040007,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
k59_835631_2	1123065.ATWL01000002_gene1691	2.15e-38	135.0	COG0779@1|root,COG0779@2|Bacteria,2I9BT@201174|Actinobacteria	201174|Actinobacteria	S	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
k59_1773966_1	595460.RRSWK_03372	2.56e-38	152.0	COG2197@1|root,COG2909@1|root,COG2197@2|Bacteria,COG2909@2|Bacteria,2IZND@203682|Planctomycetes	203682|Planctomycetes	K	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_1773966_2	1201293.AKXQ01000001_gene2036	8.34e-55	197.0	COG0834@1|root,COG2202@1|root,COG4585@1|root,COG0834@2|Bacteria,COG2202@2|Bacteria,COG4585@2|Bacteria,1NWNJ@1224|Proteobacteria	1224|Proteobacteria	T	PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HATPase_c,HTH_3,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,SBP_bac_3
k59_659905_1	880072.Desac_0386	5.12e-20	89.7	COG1900@1|root,COG1900@2|Bacteria,1P1MT@1224|Proteobacteria,42M1I@68525|delta/epsilon subdivisions,2WIQ2@28221|Deltaproteobacteria,2MQT8@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Homocysteine biosynthesis enzyme, sulfur-incorporation	-	-	-	-	-	-	-	-	-	-	-	-	HcyBio
k59_659905_2	880072.Desac_0387	6.3e-14	71.2	COG1606@1|root,COG1606@2|Bacteria,1R7UZ@1224|Proteobacteria,42Q6V@68525|delta/epsilon subdivisions,2WKIM@28221|Deltaproteobacteria,2MQGM@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PFAM asparagine synthase	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase,QueC
k59_1839513_1	1125863.JAFN01000001_gene1256	1.9e-51	176.0	COG5659@1|root,COG5659@2|Bacteria,1MWAV@1224|Proteobacteria,43BD6@68525|delta/epsilon subdivisions,2X6S2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_256270_1	935839.JAGJ01000022_gene3525	6.63e-126	370.0	COG2223@1|root,COG2223@2|Bacteria,2GJ1I@201174|Actinobacteria,4F5BF@85017|Promicromonosporaceae	201174|Actinobacteria	P	Major Facilitator	narK	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
k59_1423303_1	1283300.ATXB01000002_gene2617	4.06e-15	75.5	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,1RPYX@1236|Gammaproteobacteria,1XDV7@135618|Methylococcales	135618|Methylococcales	O	Glycoprotease family	-	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
k59_1423303_2	768671.ThimaDRAFT_0127	5.45e-22	88.2	2C9YR@1|root,3381U@2|Bacteria,1N77C@1224|Proteobacteria,1SF6W@1236|Gammaproteobacteria,1WZGR@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_190225_1	335543.Sfum_3753	1.24e-71	226.0	COG0826@1|root,COG0826@2|Bacteria,1N4QJ@1224|Proteobacteria,42YJR@68525|delta/epsilon subdivisions,2WUQ1@28221|Deltaproteobacteria,2MR6V@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Peptidase family U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
k59_1364499_2	1386089.N865_15070	4.66e-14	68.9	COG1832@1|root,COG1832@2|Bacteria,2IJYY@201174|Actinobacteria,4FJBB@85021|Intrasporangiaceae	201174|Actinobacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
k59_1598801_2	1298863.AUEP01000008_gene1111	1.64e-39	145.0	COG0601@1|root,COG0601@2|Bacteria,2GJ2C@201174|Actinobacteria,4DU00@85009|Propionibacteriales	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	oppB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_1253393_1	1515746.HR45_16410	5.8e-103	311.0	COG5505@1|root,COG5505@2|Bacteria,1MW87@1224|Proteobacteria,1RQPZ@1236|Gammaproteobacteria,2Q8YW@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF819)	-	-	-	-	-	-	-	-	-	-	-	-	DUF819
k59_1011577_2	472759.Nhal_1150	2.84e-06	52.0	COG4520@1|root,COG4520@2|Bacteria	2|Bacteria	-	-	omp	-	-	-	-	-	-	-	-	-	-	-	17kDa_Anti_2,Gly-zipper_Omp,Rick_17kDa_Anti
k59_838115_1	555778.Hneap_1458	1.66e-60	192.0	COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,1RQAB@1236|Gammaproteobacteria,1WX92@135613|Chromatiales	135613|Chromatiales	D	probably involved in intracellular septation	-	-	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
k59_662407_1	981384.AEYW01000024_gene3971	2.68e-60	203.0	COG4249@1|root,COG4249@2|Bacteria,1MXFD@1224|Proteobacteria,2TR94@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
k59_1843134_1	1123399.AQVE01000018_gene3404	1.93e-69	224.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,45ZST@72273|Thiotrichales	72273|Thiotrichales	H	MoeA N-terminal region (domain I and II)	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MobB,MoeA_C,MoeA_N,NTP_transf_3
k59_1366290_1	1415780.JPOG01000001_gene1692	3.46e-83	275.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1X46R@135614|Xanthomonadales	135614|Xanthomonadales	E	glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH,GDH_N
k59_544375_1	1049564.TevJSym_aq00710	1.84e-65	213.0	COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1J4YP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_17,RnfC_N,SLBB
k59_776638_1	314285.KT71_05607	7.31e-119	349.0	COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,1S7XK@1236|Gammaproteobacteria,1JC1M@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_1253412_1	337191.KTR9_2175	1.01e-23	101.0	COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria,4GB0V@85026|Gordoniaceae	201174|Actinobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0008661,GO:0009058,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030145,GO:0030975,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901363,GO:1901576,GO:1901681	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k59_1366296_1	517417.Cpar_0265	1.03e-24	107.0	COG0451@1|root,COG0451@2|Bacteria,1FDUB@1090|Chlorobi	1090|Chlorobi	M	3-beta hydroxysteroid dehydrogenase isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
k59_192784_1	471856.Jden_1992	1.26e-16	76.3	COG1846@1|root,COG1846@2|Bacteria,2IFQ9@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
k59_192784_2	1380354.JIAN01000008_gene3274	8.26e-41	146.0	COG0477@1|root,COG0477@2|Bacteria,2GK06@201174|Actinobacteria,4F0XY@85016|Cellulomonadaceae	201174|Actinobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
k59_1253425_1	194439.CT1717	2.09e-85	257.0	COG2191@1|root,COG2191@2|Bacteria	2|Bacteria	C	Formylmethanofuran dehydrogenase, subunit e	-	-	1.2.7.12	ko:K11261	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	FmdE,zf-dskA_traR
k59_903820_1	754252.PFREUD_19560	4.3e-39	138.0	COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,4DQ6H@85009|Propionibacteriales	201174|Actinobacteria	T	Protein of unknown function (DUF2662)	fhaA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA,Yop-YscD_cpl
k59_903820_2	1035308.AQYY01000002_gene598	4.25e-13	67.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	fhaB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
k59_1079343_1	1049564.TevJSym_av00160	6.32e-152	444.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,1RQ7G@1236|Gammaproteobacteria,1J4EK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	COG0008 Glutamyl- and glutaminyl-tRNA synthetases	glnS	GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECIAI39_1322.ECIAI39_0637	tRNA-synt_1c,tRNA-synt_1c_C
k59_25752_1	519989.ECTPHS_12398	5.77e-74	244.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1WVV0@135613|Chromatiales	135613|Chromatiales	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_838141_1	159450.NH14_16895	2.82e-09	58.5	COG1723@1|root,COG1723@2|Bacteria,1MWYM@1224|Proteobacteria	1224|Proteobacteria	S	PFAM Uncharacterised ACR, YagE family COG1723	-	-	-	-	-	-	-	-	-	-	-	-	DUF155
k59_838141_2	713586.KB900536_gene1553	2.06e-59	198.0	COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,1RNXP@1236|Gammaproteobacteria,1WX7Y@135613|Chromatiales	135613|Chromatiales	HJ	Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3,RLAN,RimK
k59_1425859_1	589865.DaAHT2_1516	2.01e-45	158.0	COG0730@1|root,COG0730@2|Bacteria,1PYDH@1224|Proteobacteria,42P28@68525|delta/epsilon subdivisions,2WK6D@28221|Deltaproteobacteria,2MIP7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_962816_1	264402.Cagra.0551s0027.1.p	6.3e-05	50.4	COG0589@1|root,2RXKR@2759|Eukaryota,37TR9@33090|Viridiplantae,3GHVN@35493|Streptophyta,3HTG6@3699|Brassicales	35493|Streptophyta	T	Universal stress protein	-	GO:0000166,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016208,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	-	-	-	-	-	-	-	-	-	Usp
k59_662436_1	1150474.JQJI01000007_gene213	5.74e-44	161.0	COG0493@1|root,COG0493@2|Bacteria,2GC1B@200918|Thermotogae	200918|Thermotogae	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
k59_1488351_1	794903.OPIT5_30560	1.55e-123	389.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,46U8Q@74201|Verrucomicrobia,3K77Q@414999|Opitutae	414999|Opitutae	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_1718168_1	1448139.AI20_03615	8.24e-75	235.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria,1Y3EG@135624|Aeromonadales	135624|Aeromonadales	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_309643_1	743525.TSC_c04540	0.000506	43.1	COG2105@1|root,COG2105@2|Bacteria,1WKJZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Gamma-glutamyl cyclotransferase, AIG2-like	-	-	-	-	-	-	-	-	-	-	-	-	GGACT
k59_1425876_1	396588.Tgr7_0765	4.25e-27	111.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1WWTC@135613|Chromatiales	135613|Chromatiales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_375619_1	765910.MARPU_11295	6.85e-44	154.0	28KC2@1|root,2Z9Z2@2|Bacteria,1RBTZ@1224|Proteobacteria,1SCMS@1236|Gammaproteobacteria,1WZG0@135613|Chromatiales	135613|Chromatiales	S	CRISPR-associated protein GSU0053 (Cas_GSU0053)	-	-	-	ko:K19131	-	-	-	-	ko00000,ko02048	-	-	-	Cas_GSU0053
k59_25803_1	228410.NE1548	3.27e-35	139.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,3724V@32003|Nitrosomonadales	28216|Betaproteobacteria	I	acyl-CoA dehydrogenase	fadE	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k59_25803_2	105559.Nwat_2283	3.67e-14	71.6	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,1WXJN@135613|Chromatiales	135613|Chromatiales	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_426986_1	1033802.SSPSH_002159	2.61e-09	58.5	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_426986_2	1051632.TPY_0213	3.3e-31	121.0	COG0836@1|root,COG0836@2|Bacteria,1TPC9@1239|Firmicutes,24908@186801|Clostridia	186801|Clostridia	M	PFAM Nucleotidyl transferase	manC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00940	MannoseP_isomer,NTP_transferase
k59_259644_1	1172188.KB911822_gene938	5.47e-87	267.0	COG0673@1|root,COG0673@2|Bacteria,2GK0F@201174|Actinobacteria,4FEVC@85021|Intrasporangiaceae	201174|Actinobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_903880_1	1245471.PCA10_03580	2.63e-23	104.0	COG2843@1|root,COG2843@2|Bacteria,1QEAE@1224|Proteobacteria,1TAVB@1236|Gammaproteobacteria,1YGMC@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
k59_1600589_1	1095767.CAHD01000222_gene1984	1.08e-52	182.0	COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,4F0JG@85016|Cellulomonadaceae	201174|Actinobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_1600589_2	590998.Celf_1576	7.92e-44	152.0	2DN32@1|root,32V8W@2|Bacteria,2H7CK@201174|Actinobacteria,4F1FA@85016|Cellulomonadaceae	201174|Actinobacteria	S	Putative bacterial sensory transduction regulator	-	-	-	-	-	-	-	-	-	-	-	-	YbjN
k59_1190913_1	765912.Thimo_1931	1.97e-127	392.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_82076_1	367299.JOEE01000001_gene2128	6.75e-131	402.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,2GM65@201174|Actinobacteria,4FE5C@85021|Intrasporangiaceae	201174|Actinobacteria	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016853,GO:0016866,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0047727,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	5.4.99.13,5.4.99.2	ko:K01848,ko:K11942	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_1079395_1	1040989.AWZU01000001_gene5962	7.17e-46	165.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,3JR79@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,HlyD_D23,Hydrolase,Hydrolase_3
k59_1843232_1	391600.ABRU01000057_gene349	7.09e-57	184.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,2U71H@28211|Alphaproteobacteria,2KGEG@204458|Caulobacterales	204458|Caulobacterales	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
k59_1600596_1	311402.Avi_1833	4.3e-22	90.5	COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,2U70K@28211|Alphaproteobacteria,4BE2N@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
k59_1315052_1	870187.Thini_0172	5.01e-111	345.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,45ZYT@72273|Thiotrichales	72273|Thiotrichales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_721110_1	765913.ThidrDRAFT_4079	1.55e-61	196.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,1WW0C@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_544438_1	743720.Psefu_0620	2.3e-135	403.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1YYEZ@136845|Pseudomonas putida group	1236|Gammaproteobacteria	M	peptidase	yebA	-	-	-	-	-	-	-	-	-	-	-	OapA,OapA_N,Peptidase_M23
k59_903895_1	1454010.JEOE01000016_gene1036	1.7e-193	550.0	COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4F0SQ@85016|Cellulomonadaceae	201174|Actinobacteria	EG	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_1425912_1	543632.JOJL01000026_gene2416	1.2e-87	279.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria,4DB0S@85008|Micromonosporales	201174|Actinobacteria	G	Fibronectin type III-like domain	bgl2	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
k59_1366371_1	977880.RALTA_B0063	0.000694	41.6	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2VIXS@28216|Betaproteobacteria,1K60B@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	gluconate 5-dehydrogenase	kduD	-	1.1.1.47,1.1.1.69	ko:K00034,ko:K00046	ko00030,ko01120,ko01200,map00030,map01120,map01200	-	R01520,R01521	RC00066	ko00000,ko00001,ko01000	-	-	-	adh_short,adh_short_C2
k59_1315069_1	1255043.TVNIR_1350	4.17e-81	268.0	28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria,1S1M3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
k59_544447_1	1384056.N787_11465	9.74e-94	306.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,1RSHX@1236|Gammaproteobacteria,1X3T3@135614|Xanthomonadales	135614|Xanthomonadales	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k59_82101_1	1288083.AUKR01000030_gene3141	1.14e-19	87.0	COG3293@1|root,COG3293@2|Bacteria,2ICBV@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_1253513_1	335543.Sfum_1034	6.54e-67	214.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,42MTI@68525|delta/epsilon subdivisions,2WIXW@28221|Deltaproteobacteria,2MR88@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
k59_1488411_1	331869.BAL199_14110	1.35e-41	152.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2U9E7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_25846_1	1121033.AUCF01000015_gene1390	1.09e-37	137.0	COG1893@1|root,COG1893@2|Bacteria,1MX5M@1224|Proteobacteria,2TVRD@28211|Alphaproteobacteria,2JZD3@204441|Rhodospirillales	204441|Rhodospirillales	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	-	-	-	-	-	-	-	-	-	-	ApbA,ApbA_C
k59_1079429_1	640081.Dsui_0457	7.22e-20	84.7	2C1YJ@1|root,32ZXK@2|Bacteria,1N98H@1224|Proteobacteria,2VVT5@28216|Betaproteobacteria,2KXDS@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF2782)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2782
k59_1079429_2	187272.Mlg_2861	2.06e-13	68.2	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1RSPA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
k59_25847_1	1415755.JQLV01000001_gene1661	7.8e-09	62.4	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	nagF	-	2.7.1.202,2.7.3.9	ko:K02768,ko:K08483,ko:K11183,ko:K11189	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7	-	-	EIIA-man,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_1
k59_1542315_1	1049564.TevJSym_ap00490	2.82e-84	265.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1J5NF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_544456_1	472759.Nhal_2244	1.41e-77	236.0	COG1544@1|root,COG1544@2|Bacteria,1RJ55@1224|Proteobacteria,1S5AA@1236|Gammaproteobacteria,1X0WB@135613|Chromatiales	135613|Chromatiales	J	PFAM Cold-shock protein, DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
k59_544456_2	472759.Nhal_2149	1.48e-39	132.0	COG1531@1|root,COG1531@2|Bacteria,1N7PM@1224|Proteobacteria,1SRSR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	AJ	Protein of unknown function (DUF504)	-	-	-	-	-	-	-	-	-	-	-	-	DUF504
k59_261595_1	861299.J421_2881	7.6e-110	337.0	COG2812@1|root,COG2812@2|Bacteria,1ZTFV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
k59_663589_1	1265313.HRUBRA_01481	3.95e-52	178.0	COG3660@1|root,COG3660@2|Bacteria,1R70U@1224|Proteobacteria,1S3JR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Nucleoside-diphosphate-sugar epimerase	-	-	-	ko:K07276	-	-	-	-	ko00000	-	-	-	Mito_fiss_Elm1
k59_135314_1	1210908.HSB1_18770	4.11e-06	48.9	COG2987@1|root,arCOG04670@2157|Archaea,2XT9Q@28890|Euryarchaeota,23T14@183963|Halobacteria	183963|Halobacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
k59_135314_2	550540.Fbal_2699	1.31e-35	134.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,iJN746.PP_1037,ic_1306.c3080	AIRS_C,GATase_5
k59_27687_1	270374.MELB17_22535	3.29e-130	385.0	COG4467@1|root,COG4467@2|Bacteria,1QW8C@1224|Proteobacteria,1S2JX@1236|Gammaproteobacteria,46BUT@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG3436 Transposase and inactivated derivatives	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_1192111_1	314345.SPV1_09103	5.22e-35	127.0	COG4803@1|root,COG4803@2|Bacteria,1RD4J@1224|Proteobacteria	1224|Proteobacteria	S	membrane protein of uknown function UCP014873	-	-	-	-	-	-	-	-	-	-	-	-	YflT
k59_486934_1	243233.MCA0596	2.58e-169	480.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1THGR@1236|Gammaproteobacteria,1XDV9@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_964501_2	998674.ATTE01000001_gene823	2.4e-61	193.0	COG4681@1|root,COG4681@2|Bacteria,1RDR9@1224|Proteobacteria,1S43N@1236|Gammaproteobacteria,460Z1@72273|Thiotrichales	72273|Thiotrichales	S	YaeQ	-	-	-	-	-	-	-	-	-	-	-	-	YaeQ
k59_261627_1	1120954.ATXE01000002_gene760	2.59e-59	187.0	COG1327@1|root,COG1327@2|Bacteria,2IHU9@201174|Actinobacteria,4DQJU@85009|Propionibacteriales	201174|Actinobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
k59_722166_1	1304883.KI912532_gene1960	1.39e-52	176.0	2DB6R@1|root,2Z7I2@2|Bacteria,1R7AG@1224|Proteobacteria,2VQZS@28216|Betaproteobacteria,2KYBI@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1012703_1	1449976.KALB_6411	1.35e-18	85.5	COG0673@1|root,COG0673@2|Bacteria,2GN2Z@201174|Actinobacteria,4E11N@85010|Pseudonocardiales	201174|Actinobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_1012703_2	1089544.KB912942_gene7390	0.000187	43.5	COG0071@1|root,COG0071@2|Bacteria,2IPNT@201174|Actinobacteria,4E55C@85010|Pseudonocardiales	201174|Actinobacteria	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_377276_1	743718.Isova_1970	9.04e-42	152.0	COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria,4F43A@85017|Promicromonosporaceae	201174|Actinobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1489869_1	1185876.BN8_03765	2.05e-55	190.0	COG1488@1|root,COG1488@2|Bacteria,4NFQK@976|Bacteroidetes,47MZ6@768503|Cytophagia	976|Bacteroidetes	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
k59_1662025_1	572547.Amico_0088	1.6e-40	145.0	COG1638@1|root,COG1638@2|Bacteria,3TAE1@508458|Synergistetes	508458|Synergistetes	G	transporter solute receptor, DctP family	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_1543425_1	367299.JOEE01000004_gene1230	2.43e-99	307.0	COG0366@1|root,COG0366@2|Bacteria,2GKT9@201174|Actinobacteria,4FEVJ@85021|Intrasporangiaceae	201174|Actinobacteria	G	Alpha amylase, catalytic domain	ams	-	2.4.1.4	ko:K05341	ko00500,map00500	-	R01823	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
k59_1777926_1	1347342.BN863_13490	1.52e-66	220.0	COG1574@1|root,COG1574@2|Bacteria,4NFMV@976|Bacteroidetes,1HZ70@117743|Flavobacteriia	976|Bacteroidetes	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k59_389149_1	765910.MARPU_04975	4.16e-44	158.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1WY1X@135613|Chromatiales	135613|Chromatiales	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
k59_435503_1	1283300.ATXB01000001_gene256	9.05e-60	206.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1XEMF@135618|Methylococcales	135618|Methylococcales	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_142523_1	1101188.KI912155_gene3606	8.56e-43	155.0	COG2834@1|root,COG2834@2|Bacteria,2GKA2@201174|Actinobacteria,1WB94@1268|Micrococcaceae	201174|Actinobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092,MucB_RseB
k59_1726947_1	1123242.JH636437_gene6091	4.7e-68	236.0	COG0433@1|root,COG0433@2|Bacteria,2IY71@203682|Planctomycetes	203682|Planctomycetes	L	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87,PDDEXK_1
k59_1784710_1	471853.Bcav_3289	2.23e-279	780.0	COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
k59_1784710_2	743718.Isova_0533	4.81e-253	704.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,4F3PY@85017|Promicromonosporaceae	201174|Actinobacteria	H	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
k59_1726949_1	1146883.BLASA_4157	1.87e-53	182.0	COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria,4EUCZ@85013|Frankiales	201174|Actinobacteria	GM	ABC transporter	rfbB2	-	3.6.3.40	ko:K01990,ko:K09691,ko:K09693	ko02010,map02010	M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.103,3.A.1.104	-	-	ABC_tran,Wzt_C
k59_1550395_1	1163617.SCD_n00481	1e-109	338.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2VHE1@28216|Betaproteobacteria	28216|Betaproteobacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
k59_95666_2	290397.Adeh_2575	5.34e-11	68.2	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria,2YYND@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh,PDZ_2
k59_611603_1	195522.BD01_0726	4.06e-19	91.7	COG0515@1|root,COG3889@1|root,arCOG03264@1|root,arCOG01672@2157|Archaea,arCOG03264@2157|Archaea,arCOG03682@2157|Archaea,2Y2TW@28890|Euryarchaeota,243EY@183968|Thermococci	183968|Thermococci	E	solute binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_95673_1	234267.Acid_7161	6.36e-72	226.0	COG2159@1|root,COG2159@2|Bacteria,3Y5M2@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Amidohydrolase 2	-	-	4.1.1.45	ko:K03392,ko:K07045	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_272830_1	1454010.JEOE01000003_gene202	2.73e-173	499.0	COG1721@1|root,COG1721@2|Bacteria,2GK9A@201174|Actinobacteria,4F118@85016|Cellulomonadaceae	201174|Actinobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF58
k59_272830_2	1454010.JEOE01000003_gene204	3.29e-50	169.0	COG1300@1|root,COG1300@2|Bacteria,2GJTG@201174|Actinobacteria,4F0H8@85016|Cellulomonadaceae	201174|Actinobacteria	S	Stage II sporulation protein M	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIM
k59_1608549_1	1385519.N801_05285	1.28e-36	132.0	COG0500@1|root,COG2226@2|Bacteria,2H9G5@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_1608549_2	1121405.dsmv_1609	1.17e-10	61.6	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,42MMZ@68525|delta/epsilon subdivisions,2WJF0@28221|Deltaproteobacteria,2MMM2@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Pyridine nucleotide-disulphide oxidoreductase	gor	-	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_435523_1	1254432.SCE1572_26375	2.8e-40	150.0	COG3591@1|root,COG3591@2|Bacteria,1R0D2@1224|Proteobacteria,43CVP@68525|delta/epsilon subdivisions,2X83P@28221|Deltaproteobacteria,2Z2MU@29|Myxococcales	28221|Deltaproteobacteria	E	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
k59_976564_1	590998.Celf_1532	8.77e-11	61.2	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4F0Z9@85016|Cellulomonadaceae	201174|Actinobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
k59_976564_2	1120936.KB907220_gene2036	1.03e-18	79.3	COG2740@1|root,COG2740@2|Bacteria,2GQH0@201174|Actinobacteria,4EKX2@85012|Streptosporangiales	201174|Actinobacteria	K	Protein of unknown function (DUF448)	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
k59_670755_2	1037409.BJ6T_41590	1.88e-15	75.1	COG0596@1|root,COG0596@2|Bacteria,1MW2P@1224|Proteobacteria,2TSS3@28211|Alphaproteobacteria,3JREG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Serine aminopeptidase, S33	MA20_32265	-	1.11.1.10	ko:K00433	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
k59_1328790_1	543913.D521_1263	1.21e-49	178.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2VI2G@28216|Betaproteobacteria,1KQ65@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
k59_1669485_1	471853.Bcav_4175	4.79e-102	308.0	COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria	201174|Actinobacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
k59_917501_1	590998.Celf_2493	1.41e-136	392.0	COG1209@1|root,COG1209@2|Bacteria,2GP20@201174|Actinobacteria,4F1ZT@85016|Cellulomonadaceae	201174|Actinobacteria	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k59_435525_1	765912.Thimo_3388	3.56e-77	243.0	COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria,1SHHY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1498486_2	357804.Ping_0269	6.12e-15	68.9	2A022@1|root,30N4C@2|Bacteria,1PU9F@1224|Proteobacteria,1SCMU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF1840)	VPA1132	-	-	-	-	-	-	-	-	-	-	-	DUF1840
k59_670759_1	670307.HYPDE_36103	7.27e-103	311.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TQRE@28211|Alphaproteobacteria,3N804@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Signal transduction histidine kinase	envZ	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_552949_1	2340.JV46_03510	2.71e-40	146.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1J4EJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the pyruvate kinase family	pykA	GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	e_coli_core.b1854,iAF1260.b1854,iB21_1397.B21_01813,iBWG_1329.BWG_1668,iEC042_1314.EC042_2021,iECBD_1354.ECBD_1784,iECB_1328.ECB_01825,iECDH10B_1368.ECDH10B_1995,iECDH1ME8569_1439.ECDH1ME8569_1801,iECD_1391.ECD_01825,iECO103_1326.ECO103_2044,iECO111_1330.ECO111_2362,iECO26_1355.ECO26_2692,iECUMN_1333.ECUMN_2152,iETEC_1333.ETEC_1887,iEcDH1_1363.EcDH1_1786,iEcE24377_1341.EcE24377A_2084,iEcHS_1320.EcHS_A1947,iEcSMS35_1347.EcSMS35_1332,iEcolC_1368.EcolC_1778,iG2583_1286.G2583_2306,iJO1366.b1854,iJR904.b1854,iSBO_1134.SBO_1162,iSSON_1240.SSON_1294,iSbBS512_1146.SbBS512_E2130,iUMNK88_1353.UMNK88_2326,iY75_1357.Y75_RS09740	PK,PK_C
k59_552949_2	1485544.JQKP01000002_gene1582	1.17e-32	122.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2VHJK@28216|Betaproteobacteria,44VJU@713636|Nitrosomonadales	28216|Betaproteobacteria	G	Belongs to the phosphoglycerate kinase family	pgk	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_846780_1	1121937.AUHJ01000006_gene2570	2.17e-96	294.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,464ET@72275|Alteromonadaceae	1236|Gammaproteobacteria	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004455,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	iEC042_1314.EC042_4152,iECABU_c1320.ECABU_c42560,iECED1_1282.ECED1_4460,iECO103_1326.ECO103_4390,iECO111_1330.ECO111_4600,iECO26_1355.ECO26_4812,iECP_1309.ECP_3967,iECSE_1348.ECSE_4057,iECUMN_1333.ECUMN_4300,iEcE24377_1341.EcE24377A_4285,iEcSMS35_1347.EcSMS35_4140,iJN746.PP_4678,iLF82_1304.LF82_1103	IlvC,IlvN
k59_784120_1	367299.JOEE01000003_gene2991	2.21e-101	299.0	COG0483@1|root,COG0483@2|Bacteria,2GP74@201174|Actinobacteria,4FF8Y@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the inositol monophosphatase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Inositol_P
k59_1328814_1	357276.EL88_10865	5.43e-08	59.7	COG3677@1|root,COG3677@2|Bacteria,4NHYS@976|Bacteroidetes,2FPPS@200643|Bacteroidia,4AW5B@815|Bacteroidaceae	976|Bacteroidetes	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
k59_1089986_1	765911.Thivi_0250	1.01e-13	70.1	COG0119@1|root,COG0119@2|Bacteria,1R7YB@1224|Proteobacteria,1RQB8@1236|Gammaproteobacteria,1WX74@135613|Chromatiales	135613|Chromatiales	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.1.182	ko:K09011	ko00290,ko00660,ko01100,ko01210,ko01230,map00290,map00660,map01100,map01210,map01230	M00535	R07399	RC00004,RC01205	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_1089986_2	572477.Alvin_2960	6.04e-46	162.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1RQ0H@1236|Gammaproteobacteria,1WWQC@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
k59_142556_1	398525.KB900701_gene7363	3.23e-42	148.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TV0G@28211|Alphaproteobacteria,3K6XF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4,PAS_7
k59_142556_2	1122134.KB893651_gene1930	5.47e-26	108.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1199578_1	593907.Celgi_2361	6.1e-98	295.0	COG1125@1|root,COG1125@2|Bacteria,2GJHI@201174|Actinobacteria,4F1YG@85016|Cellulomonadaceae	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	opuCA	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran
k59_1199578_2	1304865.JAGF01000001_gene3937	7.86e-28	107.0	COG1174@1|root,COG1174@2|Bacteria,2GMU0@201174|Actinobacteria,4F1KA@85016|Cellulomonadaceae	201174|Actinobacteria	E	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
k59_1089988_1	1415778.JQMM01000001_gene335	3.19e-69	223.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4KR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	prsR	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_1434653_1	331678.Cphamn1_1670	1.67e-103	307.0	COG1397@1|root,COG1397@2|Bacteria	2|Bacteria	O	ADP-ribosylglycohydrolase	draG	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH,Inositol_P
k59_670773_1	713586.KB900536_gene2570	4.81e-28	117.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,1WWT6@135613|Chromatiales	135613|Chromatiales	M	Surface antigen variable number	-	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,POTRA_TamA_1
k59_1550432_1	1357275.AVEL02000089_gene1171	7.94e-29	112.0	COG0515@1|root,COG0515@2|Bacteria,1RF4R@1224|Proteobacteria,1S7ZX@1236|Gammaproteobacteria,1Z588@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	KLT	Toluene tolerance protein	-	-	-	-	-	-	-	-	-	-	-	-	Kdo
k59_1857123_1	1121405.dsmv_0533	1.11e-88	275.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,42PD3@68525|delta/epsilon subdivisions,2WJ58@28221|Deltaproteobacteria,2MI5Z@213118|Desulfobacterales	28221|Deltaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_1726993_1	1049564.TevJSym_ae00930	1.64e-108	320.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1J4CK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_552965_1	1049564.TevJSym_aj00510	9.26e-87	271.0	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,1J6D6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Citrate transporter	nhaD	-	-	-	-	-	-	-	-	-	-	-	CitMHS
k59_670777_1	82654.Pse7367_0512	3.22e-63	222.0	COG0457@1|root,COG0457@2|Bacteria,1G1UY@1117|Cyanobacteria	1117|Cyanobacteria	S	Alternative locus ID	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_1,TPR_11,TPR_16,TPR_2,TPR_7,TPR_8
k59_389251_2	1068978.AMETH_3649	4.22e-104	322.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria,4E11F@85010|Pseudonocardiales	201174|Actinobacteria	KOT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_784143_1	590998.Celf_2509	2.1e-39	149.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	wgeG	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Radical_SAM,SPASM
k59_1669520_1	1306174.JODP01000018_gene4385	1.66e-57	190.0	COG3118@1|root,COG3118@2|Bacteria,2GJ7B@201174|Actinobacteria	201174|Actinobacteria	O	Thioredoxin	ybbN	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
k59_552973_1	1168067.JAGP01000001_gene1269	1.38e-20	98.6	COG3188@1|root,COG3188@2|Bacteria,1MWV6@1224|Proteobacteria,1RNWK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	outer membrane usher protein	csuD	-	-	ko:K07347	ko05133,map05133	-	-	-	ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3	-	-	PapC_C,Usher
k59_1550448_1	637389.Acaty_c0590	1.98e-19	85.1	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria,2NCVZ@225057|Acidithiobacillales	225057|Acidithiobacillales	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
k59_1550448_2	1163408.UU9_16656	2.05e-42	149.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1X30V@135614|Xanthomonadales	135614|Xanthomonadales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_846803_1	371731.Rsw2DRAFT_3254	1.2e-21	90.5	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2TV3J@28211|Alphaproteobacteria,1FBNP@1060|Rhodobacter	28211|Alphaproteobacteria	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
k59_846803_2	314724.BT0447	0.000316	44.7	COG0475@1|root,COG1762@1|root,COG0475@2|Bacteria,COG1762@2|Bacteria,2J603@203691|Spirochaetes	203691|Spirochaetes	GPT	PFAM Sodium hydrogen exchanger family	napA-1	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,PTS_EIIA_2
k59_917572_2	443144.GM21_1085	1.74e-18	87.8	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,42MY5@68525|delta/epsilon subdivisions,2WKST@28221|Deltaproteobacteria,43UAH@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Peptidase dimerisation domain	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_1784758_1	1049564.TevJSym_al00380	2.61e-94	301.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1J4XZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_201130_1	1123065.ATWL01000017_gene2022	1.29e-52	189.0	COG0515@1|root,COG0728@1|root,COG3170@1|root,COG0515@2|Bacteria,COG0728@2|Bacteria,COG3170@2|Bacteria,2GKN0@201174|Actinobacteria	201174|Actinobacteria	KLT	Integral membrane protein MviN	mviN	GO:0003674,GO:0005215,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
k59_1550455_1	1120936.KB907210_gene5603	1.6e-08	57.4	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4EGE2@85012|Streptosporangiales	201174|Actinobacteria	L	Phage integrase, N-terminal SAM-like domain	xerD	GO:0008150,GO:0040007	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_389276_1	460265.Mnod_4081	3.05e-40	150.0	COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TTEX@28211|Alphaproteobacteria,1JX4E@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Phage Terminase	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_1
k59_1608606_1	1120999.JONM01000017_gene60	4.94e-57	187.0	COG3608@1|root,COG3608@2|Bacteria,1QUH0@1224|Proteobacteria	1224|Proteobacteria	S	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
k59_729332_1	765912.Thimo_0612	9.8e-18	83.6	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1WWPS@135613|Chromatiales	135613|Chromatiales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
k59_435579_1	472759.Nhal_1890	8.15e-39	136.0	COG1818@1|root,COG1818@2|Bacteria,1NEZ5@1224|Proteobacteria	1224|Proteobacteria	S	THUMP	-	-	-	-	-	-	-	-	-	-	-	-	THUMP
k59_1090019_1	1049564.TevJSym_at00480	9.84e-46	155.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,1J4UU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
k59_1090019_2	1260251.SPISAL_00125	2.83e-44	155.0	COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S9SC@1236|Gammaproteobacteria,1WY2X@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function, DUF484	-	-	-	ko:K09921	-	-	-	-	ko00000	-	-	-	DUF484
k59_976667_1	875328.JDM601_1268	6.09e-54	185.0	COG4924@1|root,COG4924@2|Bacteria,2GNHY@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function N-terminus (DUF3323)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2399,DUF3323
k59_611675_1	765914.ThisiDRAFT_2714	4.76e-08	57.0	COG4223@1|root,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,1RYCQ@1236|Gammaproteobacteria,1WXWT@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1631)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631
k59_1264083_1	866895.HBHAL_1714	4.35e-49	174.0	COG0471@1|root,COG0471@2|Bacteria,1TSP2@1239|Firmicutes,4H9UV@91061|Bacilli,3NDIG@45667|Halobacillus	91061|Bacilli	P	Sodium:sulfate symporter transmembrane region	sdcS	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
k59_729337_2	338966.Ppro_0407	1.46e-49	171.0	COG0366@1|root,COG0366@2|Bacteria,1PDXT@1224|Proteobacteria	1224|Proteobacteria	G	alpha amylase, catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
k59_1434690_1	1384054.N790_00910	3.91e-72	233.0	COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,1RNUM@1236|Gammaproteobacteria,1X2YB@135614|Xanthomonadales	135614|Xanthomonadales	S	Deoxyribodipyrimidine photo-lyase-related protein	-	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP
k59_389300_1	1304865.JAGF01000001_gene912	9.65e-87	279.0	COG1501@1|root,COG1501@2|Bacteria,2GP4V@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
k59_1199624_1	1121456.ATVA01000013_gene996	1.89e-82	263.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,42MUF@68525|delta/epsilon subdivisions,2WK25@28221|Deltaproteobacteria,2MGDJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	DNA methylase	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
k59_1199624_2	391038.Bphy_3370	4.97e-11	63.2	2D6Q2@1|root,32TMP@2|Bacteria,1N1TP@1224|Proteobacteria,2W21S@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1857202_1	926569.ANT_10660	2.07e-77	253.0	COG0495@1|root,COG0495@2|Bacteria,2G5MX@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_1434700_1	519989.ECTPHS_01134	2.31e-72	240.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales	135613|Chromatiales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_39629_1	1121372.AULK01000003_gene307	1.39e-38	143.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,2GKQ8@201174|Actinobacteria,4FMBE@85023|Microbacteriaceae	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_tranf_2_3,Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2
k59_39629_2	590998.Celf_0721	5.78e-05	47.8	COG0489@1|root,COG3944@1|root,COG0489@2|Bacteria,COG3944@2|Bacteria,2GJ1Y@201174|Actinobacteria,4F2TG@85016|Cellulomonadaceae	201174|Actinobacteria	M	PFAM lipopolysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,CbiA,ParA,Wzz
k59_846855_1	506534.Rhein_0633	2.08e-69	229.0	COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1RNNQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Peptidase m28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
k59_495181_1	109760.SPPG_07031T0	8.41e-47	172.0	COG1506@1|root,KOG2100@2759|Eukaryota,39CYF@33154|Opisthokonta,3NW9P@4751|Fungi	4751|Fungi	O	dipeptidylpeptidase	dpp5	GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
k59_978186_1	41431.PCC8801_1913	6.23e-72	231.0	COG2308@1|root,COG2308@2|Bacteria,1G0JF@1117|Cyanobacteria,3KHEA@43988|Cyanothece	1117|Cyanobacteria	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
k59_1727869_1	485915.Dret_2002	7.42e-92	282.0	COG3464@1|root,COG3464@2|Bacteria,1R4DH@1224|Proteobacteria,43AQ4@68525|delta/epsilon subdivisions,2X63W@28221|Deltaproteobacteria,2MGXP@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM transposase IS204 IS1001 IS1096 IS1165 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,zf-ISL3
k59_1670413_1	1304865.JAGF01000001_gene3107	1.5e-62	207.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4F0H0@85016|Cellulomonadaceae	201174|Actinobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
k59_978191_1	590998.Celf_0292	2.39e-72	241.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,2GN0J@201174|Actinobacteria	201174|Actinobacteria	E	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_1,CP_ATPgrasp_2
k59_852440_2	1385515.N791_14705	8.07e-26	102.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,1S2ET@1236|Gammaproteobacteria,1X302@135614|Xanthomonadales	135614|Xanthomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0045333,GO:0050136,GO:0055114	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_788873_1	426117.M446_3036	6.99e-42	158.0	COG1231@1|root,COG1231@2|Bacteria,1MUPQ@1224|Proteobacteria,2VG4U@28211|Alphaproteobacteria,1JRT0@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM amine oxidase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_500118_1	396588.Tgr7_3255	6.08e-111	342.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1WWSJ@135613|Chromatiales	135613|Chromatiales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_1505002_1	1384054.N790_12115	1.42e-133	399.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1X4EX@135614|Xanthomonadales	135614|Xanthomonadales	J	elongation factor G	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_280504_1	1280953.HOC_18124	6.59e-74	240.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,43Z43@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	pyruvate flavodoxin ferredoxin oxidoreductase	MA20_01045	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_1732708_1	472759.Nhal_0092	6.54e-154	466.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWNH@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_986520_1	1121405.dsmv_1320	5.39e-97	307.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MIZ3@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_1023799_1	631362.Thi970DRAFT_04271	3.5e-114	344.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1WWMF@135613|Chromatiales	135613|Chromatiales	O	PFAM Magnesium chelatase, ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_148517_1	296591.Bpro_3965	9.28e-63	199.0	COG3090@1|root,COG3090@2|Bacteria,1R7TV@1224|Proteobacteria,2VPJP@28216|Betaproteobacteria,4ADJ5@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM Tripartite ATP-independent periplasmic transporter, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k59_148517_2	1123504.JQKD01000002_gene3738	9.4e-21	91.3	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria,4AA1X@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_324315_1	1479237.JMLY01000001_gene464	1.02e-37	138.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,1RSCP@1236|Gammaproteobacteria,465IU@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Transposase IS116/IS110/IS902 family	Z012_08285	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_986525_1	396588.Tgr7_1531	2.61e-91	281.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1WWJ0@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_927410_1	622637.KE124774_gene3662	2.48e-87	284.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,36XPJ@31993|Methylocystaceae	28211|Alphaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_1096282_1	765910.MARPU_12910	3.23e-14	73.6	COG1426@1|root,COG1426@2|Bacteria,1N240@1224|Proteobacteria,1RQMV@1236|Gammaproteobacteria,1WYDK@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4115)	-	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
k59_399019_1	243233.MCA1845	1.8e-85	279.0	COG4457@1|root,COG4457@2|Bacteria,1MVRQ@1224|Proteobacteria,1RPSQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Virulence	srfB	-	-	-	-	-	-	-	-	-	-	-	SrfB
k59_676821_1	471853.Bcav_0530	9.6e-66	218.0	COG5650@1|root,COG5650@2|Bacteria,2GN1J@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
k59_676821_2	101510.RHA1_ro04177	4.75e-11	66.2	2EGCD@1|root,33A46@2|Bacteria,2HHV5@201174|Actinobacteria,4G0WK@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
k59_676821_3	494419.ALPM01000114_gene890	2.94e-42	149.0	COG2233@1|root,COG2233@2|Bacteria,2GMH6@201174|Actinobacteria,1W7EF@1268|Micrococcaceae	201174|Actinobacteria	F	Permease family	rutG	-	-	ko:K02824,ko:K03458	-	-	-	-	ko00000,ko02000	2.A.40,2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
k59_1732729_2	1123070.KB899249_gene303	6.51e-23	91.7	2DQ16@1|root,334AZ@2|Bacteria,46XJ5@74201|Verrucomicrobia,2IW1X@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	SpoIIAA-like	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
k59_1675394_1	643867.Ftrac_2297	1.13e-87	278.0	COG2759@1|root,COG2759@2|Bacteria,4NG3E@976|Bacteroidetes,47T90@768503|Cytophagia	976|Bacteroidetes	F	Formate--tetrahydrofolate ligase	fhs	GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_1338789_1	1079460.ATTQ01000023_gene335	2.45e-47	155.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2U9A6@28211|Alphaproteobacteria,4BEQD@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
k59_1338789_2	670307.HYPDE_32573	7.17e-38	131.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,2TSRI@28211|Alphaproteobacteria,3N6DJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
k59_148549_1	1123236.KB899379_gene1371	9.87e-49	170.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,46543@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0042802,GO:0043021,GO:0043022,GO:0043170,GO:0043335,GO:0043412,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0051083,GO:0061077,GO:0071704,GO:0140096,GO:1901564	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
k59_986593_2	1304885.AUEY01000062_gene2639	6.19e-09	59.7	COG1112@1|root,COG1198@1|root,COG1112@2|Bacteria,COG1198@2|Bacteria,1MWMG@1224|Proteobacteria,42PMB@68525|delta/epsilon subdivisions,2WJR9@28221|Deltaproteobacteria,2MM8F@213118|Desulfobacterales	28221|Deltaproteobacteria	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DUF3320,DUF4011,DUF559
k59_1867067_1	631362.Thi970DRAFT_00990	6.55e-117	348.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,1RMGC@1236|Gammaproteobacteria,1WWQU@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
k59_1867067_2	525897.Dbac_1814	1.36e-14	78.6	COG2304@1|root,COG2885@1|root,COG2304@2|Bacteria,COG2885@2|Bacteria,1R8DG@1224|Proteobacteria,42NGC@68525|delta/epsilon subdivisions,2WMAP@28221|Deltaproteobacteria,2MGWU@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA,Phenol_MetA_deg,TSP_3,VWA
k59_1023845_1	113395.AXAI01000003_gene5872	9.54e-18	84.7	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,3JRHC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Gamma-glutamyltranspeptidase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_105563_1	670307.HYPDE_24393	9.82e-67	218.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2TR3H@28211|Alphaproteobacteria,3N69J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_280602_2	1535287.JP74_15230	5.51e-11	67.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria,3N65P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	MA20_44845	-	1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8	ko:K01782,ko:K01825	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_47716_1	765912.Thimo_2399	4.11e-132	383.0	COG3001@1|root,COG3001@2|Bacteria,1MVHX@1224|Proteobacteria,1RRC5@1236|Gammaproteobacteria,1WXE3@135613|Chromatiales	135613|Chromatiales	G	PFAM Fructosamine	-	-	-	-	-	-	-	-	-	-	-	-	Fructosamin_kin
k59_149172_1	1121937.AUHJ01000004_gene961	1.9e-23	99.4	COG0834@1|root,COG0834@2|Bacteria	2|Bacteria	ET	amino acid transport	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
k59_149172_2	1122201.AUAZ01000008_gene355	2.18e-10	60.8	COG4773@1|root,COG4773@2|Bacteria,1QWRF@1224|Proteobacteria,1RN9A@1236|Gammaproteobacteria,4665X@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1205935_2	1026882.MAMP_02626	4.82e-23	91.7	COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,1SD8H@1236|Gammaproteobacteria,461CE@72273|Thiotrichales	72273|Thiotrichales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsB	-	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
k59_324950_1	765913.ThidrDRAFT_0705	2.19e-163	462.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1WX6I@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_324950_2	572477.Alvin_1746	7.6e-07	51.6	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,1RQZJ@1236|Gammaproteobacteria,1WX5R@135613|Chromatiales	135613|Chromatiales	I	aromatic hydrocarbon degradation	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
k59_1339823_1	617140.AJZE01000014_gene1128	4.97e-102	323.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1XSUS@135623|Vibrionales	135623|Vibrionales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_442059_1	289377.HL41_06580	5.32e-08	54.7	COG0474@1|root,COG0474@2|Bacteria,2GGR5@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
k59_1505788_1	1116472.MGMO_182c00020	1.81e-11	68.6	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,1RNRZ@1236|Gammaproteobacteria,1XFC7@135618|Methylococcales	135618|Methylococcales	L	DNA RNA helicase, superfamily II	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
k59_1505788_2	765420.OSCT_2087	2.83e-59	204.0	COG0326@1|root,COG0326@2|Bacteria,2G9ND@200795|Chloroflexi	200795|Chloroflexi	O	Molecular chaperone. Has ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1441065_1	880072.Desac_0544	3.68e-107	342.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MSJC@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	por	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
k59_1381054_1	1231241.Mc24_06898	1.03e-38	140.0	COG0306@1|root,COG0306@2|Bacteria,2GCK4@200918|Thermotogae	200918|Thermotogae	P	PFAM phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_1142938_1	1397527.Q670_13050	4.9e-63	221.0	28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,1RN0X@1236|Gammaproteobacteria,1XHPT@135619|Oceanospirillales	135619|Oceanospirillales	M	cistrans isomerase	-	-	-	-	-	-	-	-	-	-	-	-	CTI
k59_1556877_1	393305.YE3315	2.99e-07	55.5	COG4795@1|root,COG4795@2|Bacteria,1RHSZ@1224|Proteobacteria,1S374@1236|Gammaproteobacteria,41D3X@629|Yersinia	1236|Gammaproteobacteria	U	prepilin peptidase dependent protein	ppdB	-	-	ko:K02680	-	-	-	-	ko00000,ko02044	-	-	-	N_methyl
k59_1868075_1	1499684.CCNP01000021_gene2814	6.43e-16	71.6	COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,24QJD@186801|Clostridia,36MNG@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
k59_1868075_2	313595.P700755_002639	3.96e-30	111.0	COG0292@1|root,COG0292@2|Bacteria,4NNKU@976|Bacteroidetes,1I1Z2@117743|Flavobacteriia,4C3U3@83612|Psychroflexus	976|Bacteroidetes	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
k59_1441078_1	1333856.L686_10030	2.06e-29	109.0	COG1226@1|root,31669@2|Bacteria,1RIW0@1224|Proteobacteria,1S6HC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG1226 Kef-type K transport systems	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
k59_1441078_2	1121940.AUDZ01000005_gene1888	3.58e-24	99.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RPM1@1236|Gammaproteobacteria,1XH5M@135619|Oceanospirillales	135619|Oceanospirillales	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	hprA	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_106580_1	335543.Sfum_1178	1.91e-96	293.0	COG1148@1|root,COG1148@2|Bacteria,1PH3R@1224|Proteobacteria,42PTD@68525|delta/epsilon subdivisions,2WIZ5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Pyr_redox_2
k59_106580_2	456442.Mboo_1839	3.99e-17	80.1	COG1148@1|root,arCOG02234@2157|Archaea,2Y7JF@28890|Euryarchaeota,2NBK7@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_9,Pyr_redox_2
k59_149200_1	379066.GAU_3281	2.42e-88	274.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1ZUIU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Catalyzes the reversible hydration of fumarate to (S)- malate	-	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
k59_559350_1	159087.Daro_3711	7.6e-23	96.7	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,2VJ62@28216|Betaproteobacteria,2KUMG@206389|Rhodocyclales	206389|Rhodocyclales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_559350_2	1049564.TevJSym_ax00110	1.8e-90	270.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_987637_1	439235.Dalk_4849	1.73e-12	67.4	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria,2MNIW@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_106591_1	3827.XP_004509722.1	3.64e-15	75.5	COG1866@1|root,2QQI5@2759|Eukaryota,37K60@33090|Viridiplantae,3GC2A@35493|Streptophyta,4JECA@91835|fabids	35493|Streptophyta	T	Phosphoenolpyruvate carboxykinase ATP	-	GO:0002376,GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006950,GO:0006952,GO:0006955,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009267,GO:0009605,GO:0009607,GO:0009620,GO:0009814,GO:0009817,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0016020,GO:0016036,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0031667,GO:0031668,GO:0031669,GO:0031974,GO:0031981,GO:0033554,GO:0042221,GO:0042594,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044238,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045087,GO:0046364,GO:0046686,GO:0050832,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0070013,GO:0071496,GO:0071704,GO:0098542,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
k59_106591_3	1168059.KB899087_gene1992	2.43e-28	110.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,2U0AU@28211|Alphaproteobacteria,3F0PE@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_1205971_1	686340.Metal_2129	7.2e-40	133.0	COG1359@1|root,COG1359@2|Bacteria,1RI7W@1224|Proteobacteria,1TKPU@1236|Gammaproteobacteria,1XGHN@135618|Methylococcales	135618|Methylococcales	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
k59_1205971_2	261292.Nit79A3_1583	1.83e-88	272.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2W9B6@28216|Betaproteobacteria,372NE@32003|Nitrosomonadales	28216|Betaproteobacteria	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
k59_1205974_1	448385.sce0411	2.49e-76	256.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2YUJI@29|Myxococcales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_207751_1	232346.JHQL01000004_gene1777	2.29e-34	127.0	COG1011@1|root,COG1011@2|Bacteria,1MVWN@1224|Proteobacteria,1RR0H@1236|Gammaproteobacteria,1XJJP@135619|Oceanospirillales	135619|Oceanospirillales	S	Haloacid dehalogenase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_207751_2	243233.MCA2870	4.03e-15	76.3	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1XDNC@135618|Methylococcales	135618|Methylococcales	EH	synthase component I	pabB	-	2.6.1.85	ko:K01665	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
k59_500794_1	743721.Psesu_2968	5.52e-71	235.0	COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,1RMNH@1236|Gammaproteobacteria,1X3UR@135614|Xanthomonadales	135614|Xanthomonadales	K	accessory protein	tex	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
k59_207752_1	1442599.JAAN01000021_gene2286	2.52e-20	94.7	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1SZUM@1236|Gammaproteobacteria,1X325@135614|Xanthomonadales	135614|Xanthomonadales	S	ABC transporter substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
k59_1790278_1	227377.CBU_0231	4.03e-129	403.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1JC97@118969|Legionellales	118969|Legionellales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_1339894_1	710696.Intca_2076	1.66e-31	112.0	COG2161@1|root,COG2161@2|Bacteria,2GV08@201174|Actinobacteria	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	relB	GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0097351	-	ko:K19159	-	-	-	-	ko00000,ko02048	-	-	-	PhdYeFM_antitox
k59_48848_1	880072.Desac_2397	1.38e-50	171.0	COG3359@1|root,COG3359@2|Bacteria,1R6A2@1224|Proteobacteria,42MVN@68525|delta/epsilon subdivisions,2WK0C@28221|Deltaproteobacteria,2MR5S@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
k59_207760_1	391626.OAN307_c25610	4.31e-36	133.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k59_1441107_1	697282.Mettu_1405	3.2e-120	377.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1XE0B@135618|Methylococcales	135618|Methylococcales	H	Vitamin B12 dependent methionine synthase, activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_1205984_1	640081.Dsui_2858	1.84e-119	358.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,2KVIV@206389|Rhodocyclales	206389|Rhodocyclales	M	lipoprotein releasing system, transmembrane protein, LolC E family	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_149227_1	999550.KI421507_gene3570	1.48e-38	138.0	COG0600@1|root,COG0600@2|Bacteria,1MU6Q@1224|Proteobacteria,2TQT6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	nasE	-	-	ko:K02050,ko:K15577	ko00910,ko02010,map00910,map02010	M00188,M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.16.1,3.A.1.16.2,3.A.1.17	-	-	BPD_transp_1
k59_149227_2	269798.CHU_1967	3.27e-59	192.0	COG1116@1|root,COG1116@2|Bacteria,4PKJ3@976|Bacteroidetes,47XCV@768503|Cytophagia	976|Bacteroidetes	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K15578	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16.1	-	-	ABC_tran
k59_1024394_1	388467.A19Y_2909	3.12e-07	51.6	COG0266@1|root,COG0266@2|Bacteria,1G0XB@1117|Cyanobacteria,1H9P8@1150|Oscillatoriales	1117|Cyanobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_400145_1	313612.L8106_08051	1.2e-48	171.0	COG3961@1|root,COG3961@2|Bacteria,1G1A5@1117|Cyanobacteria,1H9TP@1150|Oscillatoriales	1117|Cyanobacteria	GH	Belongs to the TPP enzyme family	pdc	-	4.1.1.74	ko:K04103	ko00380,ko01100,map00380,map01100	-	R01974	RC00506	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_1142975_1	561229.Dd1591_2054	7.43e-35	129.0	COG0845@1|root,COG0845@2|Bacteria,1R99C@1224|Proteobacteria,1RZS0@1236|Gammaproteobacteria,2JBP6@204037|Dickeya	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_1142975_2	1089552.KI911559_gene2917	1.45e-07	57.0	COG0845@1|root,COG0845@2|Bacteria,1N97Q@1224|Proteobacteria,2U1HJ@28211|Alphaproteobacteria,2JPCD@204441|Rhodospirillales	204441|Rhodospirillales	M	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
k59_1562338_1	1408323.JQKK01000024_gene1281	2.79e-24	107.0	COG1075@1|root,COG1075@2|Bacteria,1UYGR@1239|Firmicutes,24DRZ@186801|Clostridia,27K9J@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Domain of unknown function(DUF2779)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2779
k59_1621148_2	631362.Thi970DRAFT_02915	6.66e-42	147.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1WXAU@135613|Chromatiales	135613|Chromatiales	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
k59_1030797_1	1267005.KB911258_gene590	1.05e-82	258.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2TQKD@28211|Alphaproteobacteria,3N693@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
k59_1349077_1	1523503.JPMY01000037_gene1876	1.29e-14	68.9	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,1SD9K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_1349077_2	1279017.AQYJ01000027_gene1941	5.84e-22	88.2	COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,1SCC7@1236|Gammaproteobacteria,468CQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	GO:0002790,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009977,GO:0009987,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680	-	ko:K03116,ko:K03425	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_1795663_2	713586.KB900536_gene1939	9.28e-29	107.0	COG0664@1|root,COG0664@2|Bacteria,1PDUV@1224|Proteobacteria,1SS1D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_858888_1	1123354.AUDR01000013_gene806	1.69e-12	70.9	COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,2VJ1K@28216|Betaproteobacteria	28216|Betaproteobacteria	T	PFAM Forkhead-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
k59_115709_1	998674.ATTE01000001_gene737	7.62e-60	196.0	COG1563@1|root,COG1563@2|Bacteria,1RB3N@1224|Proteobacteria,1S74H@1236|Gammaproteobacteria,463VN@72273|Thiotrichales	72273|Thiotrichales	P	Domain related to MnhB subunit of Na+/H+ antiporter	-	-	-	-	-	-	-	-	-	-	-	-	DUF4040,MnhB
k59_115709_2	1033802.SSPSH_001592	1.93e-39	135.0	COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,1RR3K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Na H antiporter, MnhB	-	-	-	-	-	-	-	-	-	-	-	-	DUF4040,MnhB
k59_1103704_1	1131462.DCF50_p2426	1.4e-28	114.0	COG0535@1|root,COG0535@2|Bacteria,1U17E@1239|Firmicutes,25M2T@186801|Clostridia,262BB@186807|Peptococcaceae	186801|Clostridia	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
k59_794297_2	1110697.NCAST_32_00950	8.83e-21	92.0	COG1330@1|root,COG1330@2|Bacteria,2GNVB@201174|Actinobacteria,4FVAG@85025|Nocardiaceae	201174|Actinobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity	recC	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
k59_624067_1	272630.MexAM1_META1p2399	2.56e-46	164.0	COG0845@1|root,COG0845@2|Bacteria,1RC4B@1224|Proteobacteria,2U65Q@28211|Alphaproteobacteria,1JX3B@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_624067_2	1298867.AUES01000037_gene746	3.34e-48	172.0	COG0653@1|root,COG0653@2|Bacteria,1MX0P@1224|Proteobacteria,2U086@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	-	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SecA_DEAD,SecA_PP_bind
k59_1148473_1	290398.Csal_1634	5.1e-72	224.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,1XHGB@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
k59_1349099_1	314292.VAS14_01821	9.19e-07	58.2	COG0845@1|root,COG0845@2|Bacteria,1RBJ0@1224|Proteobacteria,1S2QA@1236|Gammaproteobacteria,1XT27@135623|Vibrionales	135623|Vibrionales	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k59_409279_1	522306.CAP2UW1_1910	7.75e-147	432.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VZHX@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_1877363_1	314265.R2601_02703	0.000754	48.1	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
k59_1681912_1	661367.LLO_2586	4.06e-120	357.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RNPX@1236|Gammaproteobacteria,1JCMZ@118969|Legionellales	118969|Legionellales	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
k59_1795680_1	1122179.KB890426_gene3975	7.01e-88	278.0	COG4670@1|root,COG4670@2|Bacteria,4NIRA@976|Bacteroidetes	976|Bacteroidetes	I	Coenzyme A transferase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_trans
k59_1512386_2	471853.Bcav_1208	6.17e-08	57.4	COG3147@1|root,COG3147@2|Bacteria,2HC8A@201174|Actinobacteria	201174|Actinobacteria	S	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1349112_1	1304865.JAGF01000001_gene754	2.44e-93	295.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria,4F0E3@85016|Cellulomonadaceae	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_1795681_1	1096546.WYO_4100	1.93e-41	145.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2U96P@28211|Alphaproteobacteria,1JV9J@119045|Methylobacteriaceae	28211|Alphaproteobacteria	O	subunit of a heme lyase	cycL	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
k59_1877371_1	1298867.AUES01000051_gene4511	0.000162	50.1	COG0771@1|root,COG2931@1|root,COG4625@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K2H3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,HemolysinCabind
k59_1030837_1	1463917.JODC01000002_gene817	4.91e-64	211.0	COG0657@1|root,COG0657@2|Bacteria,2I8XP@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	3.1.1.83	ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	-	R03751,R06390,R06391,R06392,R06393	RC00713,RC00983,RC01505	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3
k59_1387217_1	768671.ThimaDRAFT_0661	2.08e-67	211.0	COG3900@1|root,COG3900@2|Bacteria,1NXBA@1224|Proteobacteria,1SZCY@1236|Gammaproteobacteria,1X2JW@135613|Chromatiales	135613|Chromatiales	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
k59_409311_1	94624.Bpet2997	1.37e-55	183.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,2VHMU@28216|Betaproteobacteria,3T3QN@506|Alcaligenaceae	28216|Betaproteobacteria	O	DnaJ C terminal domain	cbpA	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
k59_858917_1	631362.Thi970DRAFT_03487	2.25e-82	251.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1WY9P@135613|Chromatiales	135613|Chromatiales	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
k59_937393_1	326424.FRAAL6406	1.77e-136	392.0	COG1335@1|root,COG1335@2|Bacteria,2I9AW@201174|Actinobacteria	201174|Actinobacteria	Q	isochorismatase hydrolase	-	-	3.5.1.110	ko:K09020	ko00240,ko01100,map00240,map01100	-	R09947,R09980	RC02737,RC02738	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
k59_996684_1	1121013.P873_08945	2.74e-33	130.0	COG2267@1|root,COG2267@2|Bacteria,1QTZP@1224|Proteobacteria,1RPB9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
k59_996686_1	1448139.AI20_13280	3.82e-37	136.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1Y3S5@135624|Aeromonadales	135624|Aeromonadales	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
k59_996686_2	395961.Cyan7425_4500	1.21e-13	72.8	COG1043@1|root,COG1043@2|Bacteria,1G1V3@1117|Cyanobacteria,3KGPY@43988|Cyanothece	1117|Cyanobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iJN678.lpxA	Acetyltransf_11,Hexapep
k59_409332_1	768671.ThimaDRAFT_4809	9.69e-116	337.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,1WW17@135613|Chromatiales	135613|Chromatiales	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_409339_1	1121123.AUAO01000002_gene414	2.17e-41	146.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,2TTXU@28211|Alphaproteobacteria,2KFZR@204458|Caulobacterales	204458|Caulobacterales	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
k59_996694_1	1408419.JHYG01000011_gene2587	6.8e-06	50.4	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,2JQYE@204441|Rhodospirillales	204441|Rhodospirillales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
k59_1103766_1	446471.Xcel_1125	2.25e-106	332.0	COG0525@1|root,COG0525@2|Bacteria,2GK8H@201174|Actinobacteria,4F3FS@85017|Promicromonosporaceae	201174|Actinobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_937417_1	479431.Namu_4031	4.48e-39	143.0	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria,4ERZR@85013|Frankiales	201174|Actinobacteria	G	Domain of unknown function (DUF3459)	nplT	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3459
k59_1739674_1	1123023.JIAI01000029_gene4468	5.96e-93	287.0	COG0659@1|root,COG0659@2|Bacteria,2H1V9@201174|Actinobacteria	201174|Actinobacteria	P	Molybdate transporter of MFS superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_MOT1
k59_1739674_2	1035308.AQYY01000002_gene644	1.4e-34	119.0	COG0526@1|root,COG0526@2|Bacteria,1VEYC@1239|Firmicutes,24QMF@186801|Clostridia,262VC@186807|Peptococcaceae	186801|Clostridia	CO	Redox-active disulfide protein	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
k59_1739674_3	573370.DMR_20130	2.02e-11	63.9	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42MF8@68525|delta/epsilon subdivisions,2WJFH@28221|Deltaproteobacteria,2M8CG@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
k59_1877448_1	1122239.AULS01000006_gene215	5.13e-22	102.0	COG2304@1|root,COG2304@2|Bacteria,2IB9H@201174|Actinobacteria,4FNP1@85023|Microbacteriaceae	201174|Actinobacteria	M	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	Gram_pos_anchor,VWA
k59_1446958_1	1265507.KB899636_gene2049	1.55e-18	89.7	COG3083@1|root,COG3083@2|Bacteria,1MX6X@1224|Proteobacteria,1RPAU@1236|Gammaproteobacteria,1Y3SS@135624|Aeromonadales	135624|Aeromonadales	S	Domain of unknown function (DUF3413)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3413,Sulfatase
k59_858948_1	631362.Thi970DRAFT_04731	4.94e-104	326.0	COG0466@1|root,COG0466@2|Bacteria,1NTR5@1224|Proteobacteria,1RPID@1236|Gammaproteobacteria,1WWG2@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_289770_1	713586.KB900536_gene2414	1.3e-82	256.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1WWRK@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
k59_858962_1	247634.GPB2148_81	1.1e-12	70.1	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	ATP-dependent helicase hrpA	hrpA	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
k59_448333_1	1049564.TevJSym_ab00030	3.22e-92	299.0	COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria,1J4PP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	COG0591 Na proline symporter	cbrA	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS
k59_331430_1	1538295.JY96_08535	7.74e-13	73.6	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2VM1M@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
k59_1349237_1	1244869.H261_11149	1.07e-45	160.0	COG0845@1|root,COG0845@2|Bacteria,1P540@1224|Proteobacteria,2U20J@28211|Alphaproteobacteria,2JQX7@204441|Rhodospirillales	204441|Rhodospirillales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
k59_409408_1	1415780.JPOG01000001_gene1823	1.07e-40	143.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1S4HN@1236|Gammaproteobacteria,1X9SZ@135614|Xanthomonadales	135614|Xanthomonadales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
k59_409408_2	1415779.JOMH01000001_gene3136	2.02e-63	211.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,1S4M3@1236|Gammaproteobacteria,1X9CV@135614|Xanthomonadales	135614|Xanthomonadales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
k59_115862_1	765911.Thivi_1840	1.93e-104	317.0	COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,1RPGZ@1236|Gammaproteobacteria,1WWD2@135613|Chromatiales	135613|Chromatiales	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
k59_1030906_1	765914.ThisiDRAFT_0700	3.6e-28	109.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1WWSB@135613|Chromatiales	135613|Chromatiales	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_1030906_2	1384056.N787_07860	3.82e-65	207.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,1X34R@135614|Xanthomonadales	135614|Xanthomonadales	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_1512477_1	768704.Desmer_0767	3.74e-52	174.0	COG0106@1|root,COG0106@2|Bacteria,1V1IR@1239|Firmicutes,24GBJ@186801|Clostridia,260RZ@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_996782_1	290400.Jann_0443	1.88e-100	310.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,2TS8B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA helicase	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
k59_1512483_1	935839.JAGJ01000029_gene13	2.86e-59	207.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4F3R5@85017|Promicromonosporaceae	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_1211795_1	472759.Nhal_1494	1.07e-56	186.0	COG0224@1|root,COG0224@2|Bacteria,1QUME@1224|Proteobacteria,1S2EG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	WbqC-like protein family	-	-	-	-	-	-	-	-	-	-	-	-	WbqC
k59_1447000_1	177437.HRM2_20940	3.05e-103	319.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria,2MIMQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3394)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_115873_1	517418.Ctha_0720	1.27e-19	81.3	COG2119@1|root,COG2119@2|Bacteria,1FFN7@1090|Chlorobi	1090|Chlorobi	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
k59_858996_1	686340.Metal_1376	6.45e-08	59.3	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1XDTR@135618|Methylococcales	135618|Methylococcales	G	alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_624181_1	765911.Thivi_1901	1.11e-95	295.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1WWF8@135613|Chromatiales	135613|Chromatiales	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K01081,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
k59_507054_1	1469245.JFBG01000012_gene931	1.37e-105	310.0	COG0607@1|root,COG0607@2|Bacteria,1REGB@1224|Proteobacteria,1S580@1236|Gammaproteobacteria,1X2R1@135613|Chromatiales	135613|Chromatiales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_742600_1	43179.ENSSTOP00000020106	1.78e-07	58.9	COG1231@1|root,KOG0029@2759|Eukaryota,38F1Z@33154|Opisthokonta,3B9CJ@33208|Metazoa,3D0AM@33213|Bilateria,486I4@7711|Chordata,49873@7742|Vertebrata,3JBQY@40674|Mammalia,35APF@314146|Euarchontoglires,4Q1BN@9989|Rodentia	33208|Metazoa	Q	Flavin containing amine oxidoreductase	il4i1	-	1.4.3.2	ko:K03334	ko00250,ko00270,ko00280,ko00350,ko00360,ko00380,ko00400,ko00950,ko01100,map00250,map00270,map00280,map00350,map00360,map00380,map00400,map00950,map01100	M00044	R00357,R00648,R00677,R00689,R00729,R02197	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
k59_409436_1	134676.ACPL_2692	8.41e-38	142.0	28HJF@1|root,2Z7UK@2|Bacteria,2ICK7@201174|Actinobacteria,4DAVB@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_409436_2	882083.SacmaDRAFT_3092	1.89e-196	555.0	COG0641@1|root,COG0641@2|Bacteria,2GMTV@201174|Actinobacteria,4E1AJ@85010|Pseudonocardiales	201174|Actinobacteria	C	Radical SAM superfamily	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Radical_SAM,SEC-C,SPASM
k59_507057_1	1121406.JAEX01000018_gene2817	2.03e-63	207.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,42N7S@68525|delta/epsilon subdivisions,2WMBC@28221|Deltaproteobacteria,2MG0T@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	AAA domain	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22
k59_213994_1	1453505.JASY01000033_gene3852	4.25e-25	108.0	COG3547@1|root,COG3547@2|Bacteria,4NKDC@976|Bacteroidetes,1HXB1@117743|Flavobacteriia,2NV7J@237|Flavobacterium	976|Bacteroidetes	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_1621280_1	765912.Thimo_2266	3.62e-06	47.8	COG1436@1|root,COG1436@2|Bacteria,1NFVS@1224|Proteobacteria,1SF77@1236|Gammaproteobacteria,1WZH0@135613|Chromatiales	135613|Chromatiales	C	ATP synthase (F/14-kDa) subunit	-	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_F
k59_1621280_2	1249627.D779_2944	2.61e-32	117.0	COG0636@1|root,COG0636@2|Bacteria,1N5D3@1224|Proteobacteria,1SBV1@1236|Gammaproteobacteria,1WZ48@135613|Chromatiales	135613|Chromatiales	U	Belongs to the V-ATPase proteolipid subunit family	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
k59_742609_1	1408473.JHXO01000009_gene3355	2.02e-99	301.0	COG0593@1|root,COG0593@2|Bacteria,4NE6Q@976|Bacteroidetes,2FNPD@200643|Bacteroidia	976|Bacteroidetes	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_1211812_1	1121939.L861_22545	5.98e-70	237.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1XNJ7@135619|Oceanospirillales	135619|Oceanospirillales	L	DEAD/H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_507061_1	1033802.SSPSH_002108	9.29e-164	476.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	acetolactate synthase	ilvI	GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1907,iB21_1397.B21_00078,iBWG_1329.BWG_0073,iECBD_1354.ECBD_3539,iECB_1328.ECB_00079,iECD_1391.ECD_00079,iUTI89_1310.UTI89_C0085,iYL1228.KPN_00082	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_215017_1	1454004.AW11_03211	6.66e-33	122.0	COG0560@1|root,COG0560@2|Bacteria,1MW38@1224|Proteobacteria,2VN83@28216|Betaproteobacteria	28216|Betaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
k59_795256_1	1286106.MPL1_05384	1.38e-39	133.0	COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,1S8VY@1236|Gammaproteobacteria,4618D@72273|Thiotrichales	72273|Thiotrichales	H	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
k59_449455_2	1223521.BBJX01000001_gene1052	1.41e-12	67.4	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,2VJUN@28216|Betaproteobacteria,4AAH6@80864|Comamonadaceae	28216|Betaproteobacteria	JM	Nucleotidyl transferase	rmlA	-	2.7.7.99	ko:K00992	ko00520,ko01100,map00520,map01100	-	R11025	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
k59_1513719_1	156889.Mmc1_2650	3.83e-59	199.0	COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,2TW7V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	PFAM transposase IS66	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_684991_1	713586.KB900536_gene2525	6.16e-112	332.0	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales	135613|Chromatiales	P	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
k59_694248_1	1380394.JADL01000002_gene1573	5e-17	85.9	COG2206@1|root,COG2206@2|Bacteria,1QWUX@1224|Proteobacteria,2TYVB@28211|Alphaproteobacteria,2JSYI@204441|Rhodospirillales	204441|Rhodospirillales	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5,PAS_4
k59_458172_1	177439.DP2628	6.35e-67	219.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,42MYT@68525|delta/epsilon subdivisions,2WM6R@28221|Deltaproteobacteria,2MI10@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_802588_1	471853.Bcav_1847	1.42e-138	399.0	COG0413@1|root,COG0413@2|Bacteria,2GJP6@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0034641,GO:0040007,GO:0042364,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_802588_2	590998.Celf_2242	1.49e-09	54.3	2EHMB@1|root,33BD3@2|Bacteria,2HXYC@201174|Actinobacteria,4F1MV@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1804873_1	1464048.JNZS01000051_gene2375	6.07e-77	233.0	COG1522@1|root,COG1522@2|Bacteria,2GP1P@201174|Actinobacteria,4DBHK@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
k59_1804873_2	1089545.KB913037_gene1004	1.4e-06	50.1	COG0161@1|root,COG0161@2|Bacteria,2GKF6@201174|Actinobacteria,4E0MM@85010|Pseudonocardiales	201174|Actinobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
k59_1693433_1	292.DM42_4490	3.5e-60	191.0	2CNUX@1|root,32SHU@2|Bacteria,1REYT@1224|Proteobacteria,2VR2A@28216|Betaproteobacteria,1K2BM@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF2760)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2760
k59_1693433_2	522306.CAP2UW1_2631	1.06e-46	165.0	COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,2VJ41@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the heat shock protein 70 family	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
k59_1693434_2	1122201.AUAZ01000001_gene2265	1.1e-27	114.0	COG3106@1|root,COG3106@2|Bacteria,1MX6E@1224|Proteobacteria,1RQ05@1236|Gammaproteobacteria,464CF@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	YcjX-like family, DUF463	ycjX	-	-	ko:K06918	-	-	-	-	ko00000	-	-	-	DUF463
k59_1693437_1	1121405.dsmv_0197	9.1e-84	266.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MINQ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
k59_1525917_1	640511.BC1002_4576	1.62e-19	92.8	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2WGP6@28216|Betaproteobacteria,1KIGD@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,dCache_1
k59_1750312_1	1336249.JADW01000042_gene2419	6.89e-27	105.0	COG0346@1|root,COG0346@2|Bacteria,1MUWY@1224|Proteobacteria,2TTMJ@28211|Alphaproteobacteria,4BAKV@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	xylE	-	1.13.11.2	ko:K00446	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
k59_1750312_2	991905.SL003B_1120	7.17e-20	90.1	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2U2RW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6,4.1.1.7	ko:K01576,ko:K01652	ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00595,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_871045_1	367299.JOEE01000012_gene3277	1.52e-70	225.0	COG0476@1|root,COG0476@2|Bacteria,2GJB6@201174|Actinobacteria,4FF9A@85021|Intrasporangiaceae	201174|Actinobacteria	H	The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are	moeB	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
k59_1458577_2	498761.HM1_1966	0.000652	42.7	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1TQNH@1239|Firmicutes,2487I@186801|Clostridia	186801|Clostridia	H	Belongs to the precorrin methyltransferase family	cobA	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15755	HEM4,Porphobil_deam,Porphobil_deamC,TP_methylase
k59_458201_1	1123401.JHYQ01000007_gene512	7.17e-137	399.0	COG1148@1|root,COG1148@2|Bacteria,1Q0ZF@1224|Proteobacteria,1RYIC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	FAD dependent oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388,ko:K16885	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Pyr_redox_2
k59_1750327_1	765952.PUV_18580	1.89e-53	185.0	COG1249@1|root,COG1249@2|Bacteria,2JFJ3@204428|Chlamydiae	204428|Chlamydiae	C	HI0933-like protein	sthA	-	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_871062_2	765914.ThisiDRAFT_1428	2.69e-53	169.0	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1WYHD@135613|Chromatiales	135613|Chromatiales	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
k59_871062_3	1049564.TevJSym_at00260	4.47e-16	77.8	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1J4GC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	iECSE_1348.ECSE_3895,iJN746.PP_5056	Metalloenzyme,Phosphodiest,iPGM_N
k59_1043675_1	261292.Nit79A3_2670	1.21e-122	378.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VNZQ@28216|Betaproteobacteria	28216|Betaproteobacteria	P	ATPase (P-type)	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_802622_1	743718.Isova_2288	2.09e-26	110.0	COG1501@1|root,COG1501@2|Bacteria,2GP4V@201174|Actinobacteria,4F45I@85017|Promicromonosporaceae	201174|Actinobacteria	G	Galactose mutarotase-like	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	Gal_mutarotas_2,Glyco_hydro_31
k59_1632732_1	933262.AXAM01000033_gene1642	2.08e-67	223.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MI52@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
k59_1574575_1	1286106.MPL1_02503	1.25e-68	235.0	COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,1RNET@1236|Gammaproteobacteria,460Z9@72273|Thiotrichales	72273|Thiotrichales	P	PFAM TonB-dependent Receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_634624_1	439235.Dalk_0247	2.18e-66	226.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIJ3@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
k59_1574578_1	1304885.AUEY01000074_gene588	1.35e-34	129.0	COG0760@1|root,COG0760@2|Bacteria,1N0CG@1224|Proteobacteria,42SAV@68525|delta/epsilon subdivisions,2WP7E@28221|Deltaproteobacteria,2MKA7@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase_2,SurA_N_3
k59_634626_1	644283.Micau_5045	6.66e-96	296.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4DA5Q@85008|Micromonosporales	201174|Actinobacteria	G	Alpha-amylase domain	aglA	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
k59_1043692_1	396588.Tgr7_1368	3.42e-46	171.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,1WWQ3@135613|Chromatiales	135613|Chromatiales	S	DNA internalization-related competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
k59_634628_1	1279017.AQYJ01000024_gene939	2.98e-65	204.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,1RSY6@1236|Gammaproteobacteria,466D6@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Reversible hydration of carbon dioxide	can	GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	iSBO_1134.SBO_0115,iSbBS512_1146.SbBS512_E0119	Pro_CA
k59_753700_1	706587.Desti_2711	7.88e-06	46.2	COG2204@1|root,COG2204@2|Bacteria,1P58Q@1224|Proteobacteria,430GN@68525|delta/epsilon subdivisions,2WVMH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_753700_2	439235.Dalk_2251	3.86e-52	168.0	COG2204@1|root,COG2204@2|Bacteria,1RJP7@1224|Proteobacteria,42SDG@68525|delta/epsilon subdivisions,2WP9A@28221|Deltaproteobacteria,2MK9J@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_753700_3	1379281.AVAG01000009_gene669	2.11e-41	139.0	COG2204@1|root,COG2204@2|Bacteria,1RH7I@1224|Proteobacteria,42STG@68525|delta/epsilon subdivisions,2WP9G@28221|Deltaproteobacteria,2MH9X@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_1574589_1	1397528.Q671_00205	4.86e-59	194.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1XHK6@135619|Oceanospirillales	135619|Oceanospirillales	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
k59_1043707_2	525903.Taci_1687	0.000275	45.8	COG1121@1|root,COG1121@2|Bacteria,3TASJ@508458|Synergistetes	508458|Synergistetes	P	ABC transporter	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
k59_342453_1	335543.Sfum_2137	6.4e-79	264.0	COG1615@1|root,COG1615@2|Bacteria,1MZ5A@1224|Proteobacteria,42M4M@68525|delta/epsilon subdivisions,2WIPI@28221|Deltaproteobacteria,2MQB3@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_694327_1	991905.SL003B_2890	9.43e-58	197.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,4BPA1@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Oligopeptide/dipeptide transporter, C-terminal region	gsiA1	-	-	ko:K02031,ko:K02032,ko:K13896	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	ABC_tran,oligo_HPY
k59_166744_2	1121405.dsmv_1951	1.31e-28	109.0	COG1014@1|root,COG1014@2|Bacteria,1N12F@1224|Proteobacteria,42NN1@68525|delta/epsilon subdivisions,2WNNF@28221|Deltaproteobacteria,2MQ0Y@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
k59_694329_1	1198232.CYCME_0318	3.09e-14	71.6	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,460GP@72273|Thiotrichales	72273|Thiotrichales	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
k59_168437_1	1125973.JNLC01000010_gene1635	2.32e-57	188.0	COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2TVMG@28211|Alphaproteobacteria,3JUTY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	NADH pyrophosphatase-like rudimentary NUDIX domain	nudC	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
k59_804085_1	930166.CD58_04485	1.13e-17	86.3	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	antiporter	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_695855_1	1385935.N836_33920	4.68e-78	272.0	COG2905@1|root,COG5001@1|root,COG2905@2|Bacteria,COG5001@2|Bacteria,1G0BS@1117|Cyanobacteria,1H9V4@1150|Oscillatoriales	1117|Cyanobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF,PAS_4,PAS_9
k59_1695351_1	398527.Bphyt_5615	3.62e-20	94.4	COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1K0RA@119060|Burkholderiaceae	28216|Betaproteobacteria	T	GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GAF,GAF_2,GGDEF,HAMP,PAS_4,PAS_9,Response_reg
k59_755443_1	1123261.AXDW01000033_gene2110	8.04e-102	318.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1X4U6@135614|Xanthomonadales	135614|Xanthomonadales	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_695867_1	1238190.AMQY01000014_gene1053	8.4e-32	126.0	COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1T3CM@1236|Gammaproteobacteria,1XK4U@135619|Oceanospirillales	135619|Oceanospirillales	L	GIY-YIG type nucleases (URI domain)	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_459749_2	33188.XP_002541680.1	1.04e-17	83.6	COG1866@1|root,2QQI5@2759|Eukaryota,38BH0@33154|Opisthokonta,3NVNR@4751|Fungi,3QKP0@4890|Ascomycota,20EC9@147545|Eurotiomycetes,3B092@33183|Onygenales	4751|Fungi	G	Phosphoenolpyruvate carboxykinase	PCK1	GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006083,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015976,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019318,GO:0019319,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
k59_1399924_1	367299.JOEE01000002_gene2609	1.56e-51	177.0	COG0772@1|root,COG0772@2|Bacteria,2GJTI@201174|Actinobacteria,4FFU6@85021|Intrasporangiaceae	201174|Actinobacteria	D	Belongs to the SEDS family	rodA	GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_1399924_2	367299.JOEE01000002_gene2608	6.26e-39	146.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4FET4@85021|Intrasporangiaceae	201174|Actinobacteria	T	Serine threonine protein phosphatase	pstP	GO:0000287,GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010563,GO:0010605,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0030145,GO:0030312,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0033673,GO:0036211,GO:0042325,GO:0042326,GO:0042578,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043392,GO:0043412,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0045859,GO:0045936,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051098,GO:0051100,GO:0051101,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
k59_168478_1	1095769.CAHF01000017_gene17	4.74e-131	390.0	COG4257@1|root,COG4257@2|Bacteria,1R448@1224|Proteobacteria,2W139@28216|Betaproteobacteria	28216|Betaproteobacteria	V	COG4257 Streptogramin lyase	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	CarboxypepD_reg
k59_1695368_2	935839.JAGJ01000011_gene483	1.07e-32	119.0	COG1970@1|root,COG1970@2|Bacteria,2IQDN@201174|Actinobacteria,4F4WX@85017|Promicromonosporaceae	201174|Actinobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
k59_804111_1	2340.JV46_07070	6.34e-63	204.0	COG2159@1|root,COG2159@2|Bacteria,1R44U@1224|Proteobacteria,1S88Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_1695373_1	265072.Mfla_0519	2.83e-32	120.0	COG3235@1|root,COG3235@2|Bacteria,1RDHR@1224|Proteobacteria,2VRKF@28216|Betaproteobacteria,2KNEN@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Cobalt uptake substrate-specific transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CbiM
k59_168491_1	1267005.KB911265_gene3651	4.18e-76	241.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2TSBN@28211|Alphaproteobacteria,3N658@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
k59_1045869_1	768671.ThimaDRAFT_3095	6.23e-221	620.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1WWC9@135613|Chromatiales	135613|Chromatiales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_168495_1	880072.Desac_0576	1.71e-18	85.9	COG0573@1|root,COG0573@2|Bacteria,1R70Z@1224|Proteobacteria,43AZJ@68525|delta/epsilon subdivisions,2X6DR@28221|Deltaproteobacteria,2MQRD@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_168495_2	1121413.JMKT01000009_gene2067	3.89e-13	67.4	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,42PP7@68525|delta/epsilon subdivisions,2WJ4T@28221|Deltaproteobacteria,2MG2Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	phosphate binding protein	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_1634649_1	240292.Ava_4780	2.55e-39	138.0	COG1028@1|root,COG1028@2|Bacteria,1G1RK@1117|Cyanobacteria,1HMYK@1161|Nostocales	1117|Cyanobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_1045875_1	323850.Shew_2749	8.91e-66	207.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,2Q9J6@267890|Shewanellaceae	1236|Gammaproteobacteria	K	Two component transcriptional regulator, winged helix family	phoB	GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0043254,GO:0044087,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_1751772_1	1267005.KB911258_gene342	4.7e-93	282.0	2F08P@1|root,33TC1@2|Bacteria,1NR2G@1224|Proteobacteria,2UQAY@28211|Alphaproteobacteria,3N85G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_1399959_2	1278073.MYSTI_02808	1.12e-80	251.0	COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria	1224|Proteobacteria	S	major pilin protein fima	MA20_16755	-	-	-	-	-	-	-	-	-	-	-	DUF1028
k59_873163_1	631362.Thi970DRAFT_04271	1.37e-63	211.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1WWMF@135613|Chromatiales	135613|Chromatiales	O	PFAM Magnesium chelatase, ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k59_1399965_2	396595.TK90_0403	1.57e-57	181.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,1S675@1236|Gammaproteobacteria,1WYPN@135613|Chromatiales	135613|Chromatiales	C	Iron--sulfur cluster insertion protein erpA	erpA	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
k59_1399965_3	1123517.JOMR01000001_gene1795	5.2e-80	251.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,45ZSV@72273|Thiotrichales	72273|Thiotrichales	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_873167_1	1167006.UWK_01016	6.37e-10	60.8	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,42P0G@68525|delta/epsilon subdivisions,2WK7Y@28221|Deltaproteobacteria,2MJ1S@213118|Desulfobacterales	28221|Deltaproteobacteria	P	TIGRFAM phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_873167_2	517418.Ctha_0918	8.71e-39	138.0	COG0573@1|root,COG0573@2|Bacteria,1FE1M@1090|Chlorobi	1090|Chlorobi	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstC	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_1634664_1	438753.AZC_3255	4.43e-53	169.0	COG3293@1|root,COG3293@2|Bacteria,1RDDI@1224|Proteobacteria,2U7E3@28211|Alphaproteobacteria,3F1N8@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DUF4096
k59_1634664_2	1423144.Gal_01396	1.42e-15	73.2	COG0309@1|root,COG3293@1|root,COG0309@2|Bacteria,COG3293@2|Bacteria,1P5HD@1224|Proteobacteria,2U4EJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_344023_1	1089552.KI911559_gene2410	6.48e-73	235.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2JQEC@204441|Rhodospirillales	204441|Rhodospirillales	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_1634667_1	880072.Desac_1354	1.39e-116	344.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,2MQ4Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	ferredoxin oxidoreductase alpha subunit	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
k59_1634667_2	880072.Desac_1355	2.65e-23	90.1	COG1144@1|root,COG1144@2|Bacteria,1N99V@1224|Proteobacteria,42V8C@68525|delta/epsilon subdivisions,2WRCP@28221|Deltaproteobacteria,2MS61@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
k59_459799_1	243365.CV_1643	1.42e-80	258.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,2KPV9@206351|Neisseriales	206351|Neisseriales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_344035_1	1123073.KB899241_gene2133	1.01e-25	106.0	COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,1S99V@1236|Gammaproteobacteria,1X5C9@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
k59_1576610_2	566466.NOR53_2311	7.08e-42	152.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RPIW@1236|Gammaproteobacteria,1J9UW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	Q	Amidohydrolase family	dan	-	3.5.1.81,3.5.1.82	ko:K01461,ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
k59_1751816_2	472759.Nhal_0222	1.38e-23	100.0	COG0784@1|root,COG2199@1|root,COG2200@1|root,COG0784@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1WWNV@135613|Chromatiales	135613|Chromatiales	T	PFAM EAL domain	-	-	-	ko:K21025	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg
k59_1159608_1	697282.Mettu_1737	1.41e-08	53.5	2E37U@1|root,32Y7H@2|Bacteria,1N8JQ@1224|Proteobacteria,1SCAH@1236|Gammaproteobacteria,1XFDS@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2956
k59_1159608_2	1123355.JHYO01000013_gene1073	7.57e-111	338.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0471 Di- and tricarboxylate transporters	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
k59_577067_1	471853.Bcav_0006	1.13e-70	233.0	COG0187@1|root,COG0187@2|Bacteria,2GKGP@201174|Actinobacteria	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_819810_1	367299.JOEE01000004_gene1039	1.37e-124	369.0	COG0366@1|root,COG0366@2|Bacteria,2GIV1@201174|Actinobacteria,4FFAA@85021|Intrasporangiaceae	201174|Actinobacteria	G	Trehalose synthase	treS	GO:0000023,GO:0000271,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016160,GO:0016161,GO:0016787,GO:0016798,GO:0016853,GO:0016866,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046872,GO:0047471,GO:0055114,GO:0071704,GO:0071944,GO:1901576	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	iNJ661.Rv0126	Alpha-amylase,Malt_amylase_C
k59_819879_1	713586.KB900536_gene2424	7.33e-22	89.7	2E445@1|root,32Z0E@2|Bacteria,1N7FY@1224|Proteobacteria,1SDJE@1236|Gammaproteobacteria,1X1WD@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_819879_2	1123392.AQWL01000006_gene640	3.28e-47	162.0	COG3271@1|root,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,2VQ1F@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2,TPR_16,TPR_17
k59_819890_2	713586.KB900536_gene1841	3.24e-32	125.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales	135613|Chromatiales	E	glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_819924_2	335543.Sfum_1747	4.26e-31	114.0	2DWSR@1|root,341Q6@2|Bacteria,1Q538@1224|Proteobacteria,430G3@68525|delta/epsilon subdivisions,2WVK2@28221|Deltaproteobacteria,2MRYW@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
## 32278 queries scanned
## Total time (seconds): 237.83567428588867
## Rate: 135.72 q/s